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33 changes: 3 additions & 30 deletions DESCRIPTION
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Expand Up @@ -7,58 +7,31 @@ Maintainer: Dawit A. Yohannes <dawit.yohannes@helsinki.fi>
URL: https://www.helsinki.fi/en/researchgroups/immunomics
Title: Differential abundance Analysis for deep sequenced immune repertoire (Repseq) datasets
Description: RepAn mainly performs differential abundance analysis by comparing immune repertoire
samples in two conditon groups to find condition associated CDR3 sequences. It conducts the comparison between sample groups
samples in two condition groups to find condition associated CDR3 sequences. It conducts the comparison between sample groups
at population level at the level of sub-repertoires, which are clusters of CDR3s that have shared immuno-genomic features across samples.
RepAn also implements basic analysis functions for immune repertoire datasets.
License: GPL-3
Depends:
R (>= 2.15.1),
R (>= 2.15.1)
Suggests:
Matrix (>= 1.2-7.1),
dynamicTreeCut,
ggplot2 (>= 1.0.0),
cluster (>= 2.0.5),
Biostrings (>= 2.38.4),
RankProd (>= 2.42.0),
doParallel (>= 1.0.10),
parallel,
preprocessCore (>= 1.32.0),
randomForest (>= 4.6-12),
gplots (>= 3.0.1),
wordspace (>= 0.2-0),
e1071 (>= 1.6-7),
data.table (>= 1.9.6),
gplots (>= 3.0.1),
kmer (>= 1.0.2),
dendextend (>= 1.3.0),
ape (>= 5.1),
RankProd,
preprocessCore,
ggseqlogo (>= 0.1),
fclust
biocViews:
Imports:
dynamicTreeCut,
ggplot2 (>= 1.0.0),
cluster (>= 2.0.5),
Biostrings (>= 2.38.4),
RankProd (>= 2.42.0),
doParallel (>= 1.0.10),
parallel,
preprocessCore (>= 1.32.0),
randomForest (>= 4.6-12),
gplots (>= 3.0.1),
wordspace (>= 0.2-0),
e1071 (>= 1.6-7),
data.table (>= 1.9.6),
gplots (>= 3.0.1),
kmer (>= 1.0.2),
dendextend (>= 1.3.0),
ape (>= 5.1),
RankProd,
preprocessCore,
ggseqlogo (>= 0.1),
fclust
LazyData: true
RoxygenNote: 6.1.0
Encoding: UTF-8

15 changes: 0 additions & 15 deletions NAMESPACE
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@@ -1,18 +1,3 @@
# Generated by roxygen2: do not edit by hand

exportPattern("^[^\\.]")
import(Matrix)
import(cluster)
import(kmer)
import(wordspace)
import(parallel)
import(doParallel)
import(gplots)
import(ggplot2)
importFrom(ape,as.AAbin)
importFrom(fclust,SIL)
importFrom(dynamicTreeCut,cutreeDynamic)
importFrom(randomForest,randomForest)
importFrom(randomForest,importance)
importFrom(e1071,cmeans)
importFrom(data.table,fread)
11 changes: 2 additions & 9 deletions README.md
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Expand Up @@ -11,16 +11,9 @@ put through a ranking based filtering to identify the most likely condition asso
For detailed description of the differential abundance analysis method, please see (https://doi.org/10.1186/s12859-021-04087-7)

## Installation
To install RepAn package in R, first install R devtools package and run its install_github function as follows:

```
install.packages("devtools")
devtools::install_github("dyohanne/RepAn")
```
If installing R package dependencies with the previous command gives errors, first install RepAn without the dependencies and use the package installation functions that come with RepAn as follows:

To install RepAn package in R, first install RepAn from the development branch without the dependencies and use the package installation functions that come with RepAn as follows:
```
devtools::install_github("dyohanne/RepAn",dependencies=F)
devtools::install_github("dyohanne/RepAn@development", dependencies = FALSE, upgrade = "never")
loadPacks()
loadBioconductorPacks()
```
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