This repository contains my reproduction of the analyses performed by Kameneva et al., published in Nature Genetics (2021). The original study, titled Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin, explores transcriptional states in human embryonic development to shed light on the origins of pediatric neuroblastoma.
Link to the study: Nature Genetics 2021
The study investigates developmental processes in adrenal glands and related lineages during weeks 6–14 of human embryogenesis using single-cell RNA sequencing. A focus is placed on understanding cell state transitions and transcriptional programs, particularly those involving Schwann cell precursors, chromaffin cells, and sympathoblasts.
- Identify cell states and transitions in developing adrenal glands.
- Characterize major transcriptional programs driving these transitions.
- Explore the relationship between developmental processes and neuroblastoma origins.