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Standardize readme #1

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Standardized README to Markdown format
rsakai10 Jun 2, 2025
e43d1b7
Update README.md
rsakai10 Jun 4, 2025
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47 changes: 22 additions & 25 deletions readme.html → README.md
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<html><pre>

This model of cardiac sarcomere dynamics linked to calcium kinetics is implemented and
This model of cardiac sarcomere dynamics linked to calcium kinetics is implemented and
modified for Neuron by Francois E. Gannier and Claire O. Malecot
from University of Tours - FRANCE
Physiologie des Cellules Cardiaques et Vasculaires
email address: francois.gannier@univ-tours.fr
from University of Tours - FRANCE
Physiologie des Cellules Cardiaques et Vasculaires
email address: francois.gannier@univ-tours.fr

It is based on the paper by :
It is based on the paper by :
Negroni JA & Lascano EC (1996) A cardiac muscle model relating sarcomere
dynamics to calcium kinetics. J Mol Cell Cardio 28:915-929 [<a href="http://www.ncbi.nlm.nih.gov/pubmed/8762031" target='url' >PubMed</a>]
dynamics to calcium kinetics. *J Mol Cell Cardio* 28:915-929 [ [PubMed](http://www.ncbi.nlm.nih.gov/pubmed/8762031) ]

this is a now classic model of contraction which has been added in some recent models
(eg : kyoto model (2003), Okada model (2005))

it uses a four-state combination to show the relation between C-Troponin, calcium,
it uses a four-state combination to show the relation between C-Troponin, calcium,
cross-bridges and Force.

The orginal model was modified to allow several stimuli with self-chosen frequency.
The orginal model was modified to allow several stimuli with self-chosen frequency.
(This allows to reproduce a staircase phenomenom)

To run the simulation auto-launch the model from modeldb or download
To run the simulation auto-launch the model from modeldb or download
and extract the archive and then compile the mod files under:

unix/linux:
-----------
type nrnivmodl in the NegroniLascano folder and then
nrngui mosinit.hoc

mswin:
------
run mknrndll and then double click on mosinit.hoc
## unix/linux:
type `nrnivmodl` in the NegroniLascano folder and then
`nrngui mosinit.hoc`

MAC OS X:
--------
## mswin:
run `mknrndll` and then double click on `mosinit.hoc`

Drag and drop the NegroniLascano folder onto the mknrndll icon. Drag
## MAC OS X:
Drag and drop the NegroniLascano folder onto the mknrndll icon. Drag
and drop the mosinit.hoc file onto the nrngui icon.

Once the simulation starts it recreates a figure similar to Fig. 2 (shown as three
panels for clarity)& 3 of the original paper.
panels for clarity) & 3 of the original paper.

![Figure 2 & 3](./fig2-3.jpg)

---

<img src="./fig2-3.jpg"" alt="Figure 2 & 3">
</pre></html>
2025-06-02: Converted README to Markdown.