Seeking Guidance on Calculating Effective Sample Size for Continuous Traits in GWAS

[showers14]

As part of our statistical analysis, we are trying to determine the effective sample size for our continuous trait of interest to ensure the robustness of our findings.

I am reaching out in the hope that you might provide some guidance or recommend resources that detail the best practices for this calculation. Specifically:

1. Are there standard formulas or tools that are widely accepted in the field for this purpose?
   How should one account for potential heterogeneity, say, differences in variance between subgroups like males vs. females?
2. Are there any pitfalls or common mistakes I should be aware of when determining the effective sample size for continuous traits?
3. Any insights or recommendations you can provide would be immensely valuable. I understand you have a busy schedule, and I truly appreciate any time you can spare to assist me with this query.

Warm regards

Yu