diff --git a/.github/workflows/smoke.yml b/.github/workflows/smoke.yml
index d6651f4ee..0b75e3a98 100644
--- a/.github/workflows/smoke.yml
+++ b/.github/workflows/smoke.yml
@@ -36,7 +36,7 @@ jobs:
       matrix:
         config:
           - {os: ubuntu-24.04, python: "3.12", ffmpeg: "8.0.1", extras: true}
-          # - {os: ubuntu-24.04, python: "pypy3.11", ffmpeg: "8.0.1"}
+          - {os: ubuntu-24.04, python: "pypy3.11", ffmpeg: "8.0.1"}
           - {os: macos-14, python: "3.11", ffmpeg: "8.0.1"}
 
     env:
diff --git a/setup.py b/setup.py
index 1db60b649..9be9acb27 100644
--- a/setup.py
+++ b/setup.py
@@ -24,9 +24,11 @@
 if sys.implementation.name == "cpython":
     py_limited_api = True
     options = {"bdist_wheel": {"py_limited_api": "cp311"}}
+    define_macros = [("Py_LIMITED_API", 0x030B0000)]
 else:
     py_limited_api = False
     options = {}
+    define_macros = []
 
 # Monkey-patch Cython to not overwrite embedded signatures.
 old_embed_signature = EmbedSignature._embed_signature
@@ -148,7 +150,7 @@ def parse_cflags(raw_flags):
     include_dirs=[f"{IMPORT_NAME}/filter"] + extension_extra["include_dirs"],
     libraries=extension_extra["libraries"],
     library_dirs=extension_extra["library_dirs"],
-    define_macros=[("Py_LIMITED_API", 0x030B0000)],
+    define_macros=define_macros,
     py_limited_api=py_limited_api,
 )
 
@@ -194,7 +196,7 @@ def parse_cflags(raw_flags):
                 libraries=extension_extra["libraries"],
                 library_dirs=extension_extra["library_dirs"],
                 sources=[pyx_path],
-                define_macros=[("Py_LIMITED_API", 0x030B0000)],
+                define_macros=define_macros,
                 py_limited_api=py_limited_api,
             ),
             compiler_directives=compiler_directives,