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100644 diff --git a/.gitignore b/.gitignore old mode 100755 new mode 100644 index 71a1892..38d8b31 --- a/.gitignore +++ b/.gitignore @@ -5,7 +5,3 @@ *.rds *.Rbin *.gz -*.pdf -*.csv -*.csv -*.pdf diff --git a/DESCRIPTION b/DESCRIPTION old mode 100755 new mode 100644 index 41590d2..800bc30 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -10,13 +10,25 @@ Authors@R: c( comment = c(ORCID = "0000-0001-8906-5270"))) Description: Though there are many algorithms for enrichment analysis, most do not perform permutation statistics which do not rely on assumptions about the input distribution and do not allow for analysis of multiple omics data types. This tool enables users to input any omics data type as long as they provide corresponding set annotations or use the default gene set annotations. Users can also use this tool to prioritize drug mechanisms of action based on selective toxicity using drug mechanism enrichment analysis (https://belindabgarana.github.io/DMEA) as long as they provide expression data which corresponds to the input omics data type or use the default CCLE RNA-seq data (version 19Q4) and PRISM drug screen of 327 adherent cancer cell lines. License: MIT -URL: https://github.com/PNNL-CompBio/panSEA -BugReports: https://github.com/PNNL-CompBio/panSEA/issues +URL: https://github.com/BelindaBGarana/panSEA +BugReports: https://github.com/BelindaBGarana/panSEA/issues Encoding: UTF-8 -Depends: ggplot2 (>= 3.4.4) Imports: ggplot2, DMEA, plyr, dplyr, Biobase, data.table, ggcorrplot, ggvenn, GSA, igraph, limma, metap, msigdbr, multtest, qvalue, reshape2, stats, stringr, viridis, visNetwork, utils VignetteBuilder: knitr Suggests: BiocStyle, knitr, rmarkdown -RoxygenNote: 7.3.3 +Collate: + 'mDEG.R' + 'ssGSEA.R' + 'DMEA_cell_corr.R' + 'DMEA_gene_corr.R' + 'compile_mDEG.R' + 'compile_mGSEA.R' + 'compile_mDMEA.R' + 'mGSEA.R' + 'mDMEA.R' + 'mDMEA_cell_corr.R' + 'mDMEA_gene_corr.R' + 'netSEA.R' + 'panSEA.R' diff --git a/DISCLAIMER b/DISCLAIMER deleted file mode 100644 index a94fefc..0000000 --- a/DISCLAIMER +++ /dev/null @@ -1,23 +0,0 @@ -DISCLAIMER -This material was prepared as an account of work sponsored by an agency of the -United States Government. Neither the United States Government nor the United -States Department of Energy, nor Battelle, nor any of their employees, nor any -jurisdiction or organization that has cooperated in the development of these -materials, makes any warranty, express or implied, or assumes any legal -liability or responsibility for the accuracy, completeness, or usefulness or -any information, apparatus, product, software, or process disclosed, or -represents that its use would not infringe privately owned rights. - -Reference herein to any specific commercial product, process, or service by -trade name, trademark, manufacturer, or otherwise does not necessarily -constitute or imply its endorsement, recommendation, or favoring by the United -States Government or any agency thereof, or Battelle Memorial Institute. The -views and opinions of authors expressed herein do not necessarily state or -reflect those of the United States Government or any agency thereof. - - PACIFIC NORTHWEST NATIONAL LABORATORY - operated by - BATTELLE - for the - UNITED STATES DEPARTMENT OF ENERGY - under Contract DE-AC05-76RL01830 diff --git a/Examples/.DS_Store b/Examples/.DS_Store new file mode 100644 index 0000000000000000000000000000000000000000..bc40d0874d012e626989622b3275b5057a8efaa6 GIT binary patch literal 10244 zcmeHMTWb?R6h7Nl-57-m3SKCz2vXWubL|B|(lk~2+DLt<5_2<+ZZaXaDy5Kj^$+;q zvk#&OzUY$(KKbq+@K^Yx-^^~3y(Km&ty*Sa=j`s8GqdOWX6DSy5|NT<=0ijp5vjPi zoIHihBXK>yTxraFGYhG}o~TX@VpOB2Yr3nnd?68#2uK7Z0uljt;0?e#Yu@9Qsxo?iGUjczIXT09Iew9m8|=B zmdola3oQne@)L6Imq?`n#zz3%1~CkXLv4A4)vueNvm`lcXQ&o zwWhmjeq*V5dW4$OXth8O#mPefEoP`iMep{;iVjaMx!SA3Ck9^%$oJ?4Ed!$&ix*di ztaVrqtcYo@wi@st16Jxlyapbs;#6jjz9>@;UuH+He+aMWoukzWx`i(@Frm))*c%^v$PTh&YTMlkqY85^HCcKn2@s($r;YKv{B8kt73p2*ZT`O_W7^laxo 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+"proline",-0.110353079166665 +"propionylcarnitine",-0.352922133333331 +"putrescine",-0.149027291666666 +"pyroglutamic.acid",0.0284851666666706 +"ribose.5.P.ribulose5.P",0.0654795958333345 +"sarcosine",-0.10880102083333 +"SDMA.ADMA",-0.190176537499998 +"serine",0.295831595833335 +"serotonin",0.0552602458333329 +"sorbitol",-0.0636386999999967 +"stearoylcarnitine",0.0951335583333348 +"succinate.methylmalonate",-0.103723762499999 +"sucrose",0.00522682500000116 +"taurine",-0.215636758333331 +"taurocholate",0.0419375750000004 +"taurodeoxycholate.taurochenodeoxycholate",-0.0820512999999989 +"thiamine",0.206043350000003 +"threonine",0.189575637500001 +"thymidine",-0.643547141666664 +"thymine",0.0567070458333356 +"thyroxine",-0.00779467083333074 +"trimethylamine.N.oxide",0.199691975000002 +"tryptophan",0.00439269166666723 +"tyrosine",0.121640591666667 +"UDP.galactose.UDP.glucose",-0.0511230458333332 +"UMP",0.0627405083333343 +"uracil",0.00209480833333853 +"urate",0.148778220833335 +"uridine",-0.00660626249999652 +"valerylcarnitine.isovalerylcarnitine.2.methylbutyroylcarnitine",0.094920475000003 +"valine",0.216623583333336 +"X1.methylnicotinamide",0.380228920833334 +"X2.aminoadipate",-0.148857954166664 +"X2.deoxyadenosine",-0.258411383333331 +"X2.deoxycytidine",-0.872290891666666 +"X2.hydroxyglutarate",0.113030700000001 +"X3.methyladipate.pimelate",0.0389818500000025 +"X3.phosphoglycerate",0.0838171791666689 +"X4.pyridoxate",0.132790212500002 +"X5.adenosylhomocysteine",0.151265704166669 +"X5.HIAA",-0.0473472458333308 +"X6.phosphogluconate",0.126974662500001 +"xanthine",-0.139633316666665 +"xanthosine",0.0225466583333356 diff --git a/Examples/Coldren_metabolomics_DEGs_before_avg.csv b/Examples/Coldren_metabolomics_DEGs_before_avg.csv new file mode 100644 index 0000000..923d859 --- /dev/null +++ b/Examples/Coldren_metabolomics_DEGs_before_avg.csv @@ -0,0 +1,226 @@ +"Metabolite","Log2FC","AveExpr","t","P.Value","adj.P.Val","B","Log2Transformed" +"acetylcarnitine",-0.432566808333332,5.96160849,-3.54375838235734,0.00175736278099469,0.156033643163047,-1.16110904842478,FALSE +"acetylcholine",0.0848597708333374,6.229074175,0.251225587380649,0.803898638778565,0.910438675461403,-5.92575524973369,FALSE +"acetylglycine",0.157840045833336,5.76356869,1.36651168074923,0.185154817436294,0.722065706826601,-5.08357447358003,FALSE +"aconitate",-0.127447645833334,5.9082364,-1.18152559162319,0.249617646805812,0.767896083722976,-5.29705401158715,FALSE +"adenine",0.0936795041666674,5.819529415,0.90431107944152,0.375322741845975,0.780488194251245,-5.56511694660477,FALSE +"adenosine",0.0263129250000027,6.030221655,0.111309151070361,0.91234898390346,0.979883583871828,-5.95045091585117,FALSE +"adipate",0.0499140708333332,5.840321505,0.580674177599498,0.567177487666839,0.868205045642314,-5.7933291810421,FALSE +"alanine",0.058624316666668,5.818558715,0.358425270549357,0.723335012485892,0.89915940885139,-5.89402322381722,FALSE +"allantoin",-0.147068362499999,5.785034045,-1.47652192223494,0.153534963642831,0.722065706826601,-4.94432614426337,FALSE +"alpha.glycerophosphate",-0.288459241666666,5.80032633,-1.62228396201603,0.118542705210367,0.672057543268584,-4.74649995876463,FALSE +"alpha.glycerophosphocholine",-0.380057358333332,5.825983235,-2.04200302868148,0.0529309603689747,0.579393747912754,-4.10023756956233,FALSE +"alpha.hydroxybutyrate",0.0414708541666702,5.7970432,0.505310572246251,0.618209128864462,0.868205045642314,-5.83269838654661,FALSE +"alpha.ketoglutarate",0.106047975000002,5.93717756,1.11244176297737,0.277584281901749,0.767896083722976,-5.36983375322221,FALSE +"AMP",0.0345036250000037,5.838322275,0.437142804905241,0.666135903330892,0.874573158921392,-5.86370701624836,FALSE +"anserine",0.00612032500000215,5.847879295,0.0579633716698545,0.954284736922955,0.986327843853534,-5.95485339145699,FALSE +"anthranilic.acid",-0.573772275,6.24255256,-3.68755509941443,0.00123729766510131,0.156033643163047,-0.850976989352204,FALSE +"arachidonyl_carnitine",0.0517635541666701,5.779710795,0.554773588156459,0.584471924351456,0.868205045642314,-5.80745846562266,FALSE +"arginine",-0.151282108333334,5.889837785,-1.5957155265458,0.124373588758417,0.672057543268584,-4.7836536778121,FALSE +"asparagine",-0.625436620833331,5.781932215,-2.81766634809118,0.00983695795840006,0.316187934377145,-2.67146832133942,FALSE +"aspartate",-0.118030024999996,5.82485171,-1.09418816936278,0.28534104959342,0.767896083722976,-5.38841382257688,FALSE +"beta.alanine",-0.0878314624999978,6.145741685,-0.49720002238707,0.623826870044512,0.868205045642314,-5.83661775826569,FALSE +"betaine",-0.0747323833333304,5.807496345,-0.852826808017903,0.402659334119757,0.795681913792805,-5.60769212639161,FALSE +"butyrobetaine",-0.217442329166664,5.91459829,-1.84236506067303,0.0785152124075286,0.600563264226451,-4.4209778132649,FALSE 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+
+
+ + + + diff --git a/Examples/Fig2/DMEA/DMEA_mean_results.csv b/Examples/Fig2/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..7bbc1a0 --- /dev/null +++ b/Examples/Fig2/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"MDM inhibitor",2.14666666666667,0.0503322295684717,NA,"GSE12790, GSE31625, Coldren et al",3,3,"GSE12790, GSE31625, Coldren et al",NA +"sterol demethylase inhibitor",1.38666666666667,0.416813307529082,0.010345636129814,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.119713789502134 +"FLT3 inhibitor",1.37433333333333,0.349322677954543,0.023597478013491,"GSE12790, GSE31625, Coldren et al",3,0,"",0.165340424169999 +"ribonucleotide reductase inhibitor",1.36566666666667,0.373384966667558,0.0235585715825658,"GSE12790, GSE31625, Coldren et al",3,0,"",0.165340424169999 +"RAF inhibitor",1.35833333333333,0.372704082796705,0.0206048682585458,"GSE12790, GSE31625, Coldren et al",3,1,"GSE31625",0.165340424169999 +"PARP inhibitor",1.32666666666667,0.0702376916856849,0.0704098242875693,"GSE12790, GSE31625, Coldren et al",3,0,"",0.291413422411389 +"DNA inhibitor",1.31666666666667,0.257358375292768,0.0744046133712215,"GSE12790, GSE31625, Coldren et al",3,0,"",0.291413422411389 +"thymidylate synthase inhibitor",1.30966666666667,0.60148178138106,0.456873029473853,"GSE12790, GSE31625, Coldren et al",3,1,"Coldren et al",0.75523908953841 +"Aurora kinase inhibitor",1.30333333333333,0.183393929379719,0.0646135607031861,"GSE12790, GSE31625, Coldren et al",3,0,"",0.290761023164338 +"acetylcholine receptor agonist",1.26,0.147309198626562,0.110483164838256,"GSE12790, GSE31625, Coldren et al",3,0,"",0.357965454075951 +"antioxidant",1.251,0.308501215556762,0.0820746207912007,"GSE12790, GSE31625, Coldren et al",3,0,"",0.302183831094875 +"CC chemokine receptor antagonist",1.23666666666667,0.172433562085034,0.13248906461371,"GSE12790, GSE31625, Coldren et al",3,0,"",0.383838676566381 +"potassium channel blocker",1.22,0.0721110255092798,0.201771775417744,"GSE12790, GSE31625, Coldren et al",3,0,"",0.46695753739535 +"BCL inhibitor",1.172,0.222243110129426,0.211785491605301,"GSE12790, GSE31625, Coldren et al",3,0,"",0.476517356111927 +"serotonin receptor agonist",1.15866666666667,0.367267386699845,0.1594866395273,"GSE12790, GSE31625, Coldren et al",3,0,"",0.43061392672371 +"DNA synthesis inhibitor",1.14966666666667,0.382805868990188,0.172730012687971,"GSE12790, GSE31625, Coldren et al",3,0,"",0.437222844616427 +"phosphatase inhibitor",1.14666666666667,0.140118997046558,0.282499826027809,"GSE12790, GSE31625, Coldren et al",3,0,"",0.544821093053631 +"androgen receptor antagonist",1.143,0.300561141866343,0.21887597483729,"GSE12790, GSE31625, Coldren et al",3,0,"",0.47916091788704 +"protein synthesis inhibitor",1.13933333333333,0.209478718091679,0.247157589313257,"GSE12790, GSE31625, Coldren et al",3,0,"",0.521365104914305 +"DNA alkylating agent",1.136,0.249415316289918,0.266623997127525,"GSE12790, GSE31625, Coldren et al",3,0,"",0.526744969934867 +"HCV inhibitor",1.10733333333333,0.281746931364537,0.294959567007072,"GSE12790, GSE31625, Coldren et al",3,0,"",0.555621509943555 +"FGFR inhibitor",1.09833333333333,0.382764070065796,0.254352052198402,"GSE12790, GSE31625, Coldren et al",3,0,"",0.521365104914305 +"serotonin receptor antagonist",1.07833333333333,0.235283516918065,0.322722675011014,"GSE12790, GSE31625, Coldren et al",3,0,"",0.594103106270275 +"RET tyrosine kinase inhibitor",1.01633333333333,0.108859236325327,0.529293518522628,"GSE12790, GSE31625, Coldren et al",3,0,"",0.808920283025149 +"ATPase inhibitor",0.996333333333333,0.307197547733268,0.50384621764204,"GSE12790, GSE31625, Coldren et al",3,0,"",0.799917370466552 +"JAK inhibitor",0.948333333333333,0.22618208004467,0.64186893984114,"GSE12790, GSE31625, Coldren et al",3,0,"",0.912129546090042 +"CDK inhibitor",0.943666666666667,0.187163921024682,0.676875746286401,"GSE12790, GSE31625, Coldren et al",3,0,"",0.945291990503422 +"acetylcholine receptor antagonist",0.925333333333333,0.350487279845265,0.58120045216875,"GSE12790, GSE31625, Coldren et al",3,0,"",0.871800678253124 +"HMGCR inhibitor",0.921,1.58726588824935,0.0360007018713121,"GSE12790, GSE31625, Coldren et al",3,1,"Coldren et al",0.182253553223518 +"mTOR inhibitor",0.918333333333333,0.0819410357106458,0.737115606533089,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674 +"adrenergic receptor antagonist",0.847333333333333,0.265846446907483,0.788879740235108,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674 +"cyclooxygenase inhibitor",0.811666666666667,0.361328567004234,0.806363150486619,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674 +"PLK inhibitor",0.79,1.66352036356637,0.000427842408988178,"GSE12790, GSE31625, Coldren et al",3,1,"Coldren et al",0.0346552351280424 +"dopamine receptor antagonist",0.764666666666667,0.124500334671572,0.941927144670964,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058 +"bromodomain inhibitor",0.639333333333333,1.5341738276132,0.840360448995707,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.972417090980747 +"DNA polymerase inhibitor",0.621,1.36750246800509,0.092406184136918,"GSE12790, GSE31625, Coldren et al",3,0,"",0.325430474569146 +"topoisomerase inhibitor",0.592,1.31931497376479,0.132684974615539,"GSE12790, GSE31625, Coldren et al",3,0,"",0.383838676566381 +"PDGFR tyrosine kinase receptor inhibitor",0.581666666666667,1.08298584170493,0.456548293224534,"GSE12790, GSE31625, Coldren et al",3,0,"",0.75523908953841 +"retinoid receptor agonist",0.542666666666667,1.40226293302409,0.0755516280325824,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.291413422411389 +"PPAR receptor agonist",0.526666666666667,1.5844978173962,0.0410151922447099,"GSE12790, GSE31625, Coldren et al",3,0,"",0.195425327754206 +"microtubule inhibitor",0.521333333333333,1.496323939972,0.0265361174593826,"GSE12790, GSE31625, Coldren et al",3,1,"Coldren et al",0.165340424169999 +"cytochrome P450 inhibitor",0.465333333333333,1.0017346621403,0.629952169042457,"GSE12790, GSE31625, Coldren et al",3,0,"",0.911180815936412 +"estrogen receptor antagonist",0.451,1.31093592520764,0.257464249340397,"GSE12790, GSE31625, Coldren et al",3,0,"",0.521365104914305 +"opioid receptor agonist",0.447666666666667,1.23980818408871,0.33125873668547,"GSE12790, GSE31625, Coldren et al",3,0,"",0.596265726033847 +"sodium channel blocker",0.421,0.956343557514767,0.738666445881696,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674 +"AP inhibitor",0.409666666666667,0.95569311671338,0.813663493956565,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674 +"tubulin polymerization inhibitor",0.401,1.44817920161836,0.120071116577302,"GSE12790, GSE31625, Coldren et al",3,0,"",0.37406770933698 +"HDAC inhibitor",0.385333333333333,1.40485776266971,0.197916654109267,"GSE12790, GSE31625, Coldren et al",3,0,"",0.46695753739535 +"glycogen synthase kinase inhibitor",0.381,1.03927426601451,0.69858587218184,"GSE12790, GSE31625, Coldren et al",3,0,"",0.959075519436086 +"KIT inhibitor",0.367333333333333,1.11331097781947,0.607825963596335,"GSE12790, GSE31625, Coldren et al",3,0,"",0.895161873660057 +"calcium channel blocker",0.342666666666667,0.976959228081363,0.78433674643619,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674 +"Bcr.Abl kinase inhibitor",0.316666666666667,1.89315433426156,0.004092042160623,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.0784884070929638 +"growth factor receptor inhibitor",0.296333333333333,1.41853104771568,0.158790324475968,"GSE12790, GSE31625, Coldren et al",3,0,"",0.43061392672371 +"proteasome inhibitor",0.276666666666667,1.48288008056395,0.165531633980907,"GSE12790, GSE31625, Coldren et al",3,0,"",0.432518140401725 +"phosphodiesterase inhibitor",0.27,1.02712365370485,0.800031448198042,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674 +"benzodiazepine receptor agonist",0.25,0.742915203774966,0.983930662368058,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058 +"progesterone receptor agonist",0.231666666666667,0.923320276682654,0.894771119370493,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058 +"bacterial DNA gyrase inhibitor",0.225,1.03791955372273,0.759456933181127,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674 +"Abl kinase inhibitor",0.206666666666667,1.82418018115901,0.0258734640205324,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.165340424169999 +"NFkB pathway inhibitor",0.186333333333333,0.865263158428309,0.963328004423398,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058 +"glucocorticoid receptor agonist",0.102666666666667,0.857242283915891,0.952868910836111,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058 +"histamine receptor antagonist",0.053,0.934038007791974,0.920017368645138,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058 +"MET inhibitor",-0.0723333333333334,1.34172885984216,0.359067235983164,"GSE12790, GSE31625, Coldren et al",3,0,"",0.632270567709484 +"bacterial 50S ribosomal subunit inhibitor",-0.110333333333333,0.912943225690039,0.943805653362881,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058 +"PI3K inhibitor",-0.187666666666667,0.822255637459138,0.97876803772867,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058 +"glutamate receptor antagonist",-0.254333333333333,1.15984496090354,0.513527200793342,"GSE12790, GSE31625, Coldren et al",3,0,"",0.799917370466552 +"adenosine receptor antagonist",-0.28,1.95829007044411,0.00107604150193936,"GSE12790, GSE31625, Coldren et al",3,2,"GSE12790, Coldren et al",0.043579680828544 +"VEGFR inhibitor",-0.325333333333333,0.734679748824842,0.979725457342251,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058 +"p38 MAPK inhibitor",-0.385,0.886869212454689,0.859526714230959,"GSE12790, GSE31625, Coldren et al",3,0,"",0.980586814826869 +"estrogen receptor agonist",-0.478666666666667,1.12144118585565,0.508218109136666,"GSE12790, GSE31625, Coldren et al",3,0,"",0.799917370466552 +"ALK tyrosine kinase receptor inhibitor",-0.526666666666667,1.16834640981745,0.378819080813023,"GSE12790, GSE31625, Coldren et al",3,0,"",0.652858415869253 +"adrenergic receptor agonist",-0.687333333333333,0.0859205058954691,0.96995329091943,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058 +"HSP inhibitor",-0.723333333333333,1.54778336124063,0.0329098455608673,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.182253553223518 +"AKT inhibitor",-0.723333333333333,1.72653796174116,0.00765536439613635,"GSE12790, GSE31625, Coldren et al",3,2,"GSE31625, Coldren et al",0.103347419347841 +"tyrosine kinase inhibitor",-0.808666666666667,0.188473694008828,0.83801239276031,"GSE12790, GSE31625, Coldren et al",3,0,"",0.972417090980747 +"MEK inhibitor",-0.834666666666667,1.12718114486241,0.104168000000676,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.351567000002281 +"vitamin D receptor agonist",-0.856666666666667,2.2590337167323,0.00215111152782059,"GSE12790, GSE31625, Coldren et al",3,3,"GSE12790, GSE31625, Coldren et al",0.058080011251156 +"DNA methyltransferase inhibitor",-1.166,0.427537132890232,0.196069825511376,"GSE12790, GSE31625, Coldren et al",3,0,"",0.46695753739535 +"CHK inhibitor",-1.26566666666667,0.888924256240842,0.783463278348338,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.969216808977674 +"TGF beta receptor inhibitor",-1.302,0.539344046041115,0.0212004990086226,"GSE12790, GSE31625, Coldren et al",3,1,"GSE31625",0.165340424169999 +"protein tyrosine kinase inhibitor",-1.306,0.544231568360381,0.034864770244826,"GSE12790, GSE31625, Coldren et al",3,1,"Coldren et al",0.182253553223518 +"src inhibitor",-1.61333333333333,0.415852537966685,0.00484496340080023,"GSE12790, GSE31625, Coldren et al",3,2,"GSE12790, GSE31625",0.0784884070929638 +"EGFR inhibitor",-2.19666666666667,0.161658075373095,NA,"GSE12790, GSE31625, Coldren et al",3,3,"GSE12790, GSE31625, Coldren et al",NA diff --git a/Examples/Fig2/DMEA/DMEA_results.csv b/Examples/Fig2/DMEA/DMEA_results.csv new file mode 100644 index 0000000..24b20c1 --- /dev/null +++ b/Examples/Fig2/DMEA/DMEA_results.csv @@ -0,0 +1,250 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"GSE12790","Pearson.est","EGFR inhibitor",-0.77405,-2.05,0.00829,1317,0.0725,"WZ8040, PD.153035, ARRY.334543, brigatinib, vandetanib, rociletinib, PD.168393, osimertinib, lapatinib, BMS.690514, neratinib, gefitinib, afatinib, pelitinib, AZD8931, dacomitinib, XL.647, canertinib, erlotinib, icotinib, poziotinib",2.08144546944973,1.13966199342901,TRUE +"GSE12790","Pearson.est","Abl kinase inhibitor",-0.71056,-1.89,0.0327,1270,0.0717,"metatinib, GZD824, bosutinib, ZM.306416, ponatinib, dasatinib",1.48545224733971,1.1444808443322,TRUE +"GSE12790","Pearson.est","acetylcholine receptor agonist",0.52038,1.29,0.175,586,0.658,"nefiracetam, nicotine, xanomeline, pilocarpine",0.756961951313706,0.181774106386044,FALSE +"GSE12790","Pearson.est","acetylcholine receptor antagonist",0.53465,1.33,0.145,42,0.706,"diphemanil",0.838631997765025,0.151195298948196,FALSE +"GSE12790","Pearson.est","adenosine receptor antagonist",0.78673,1.97,0.00159,287,0.025,"istradefylline, MRS.1220, SCH.58261, sulmazole, PSB.1115",2.79860287567955,1.60205999132796,TRUE +"GSE12790","Pearson.est","adrenergic receptor agonist",-0.30286,-0.786,0.688,434,0.889,"buphenine, metaraminol, xylazine, isoetharine, lidamidine, oxymetazoline, isoxsuprine, ritodrine, norepinephrine, methyldopa, midodrine, epinephrine, terbutaline, clenbuterol, A61603",0.162411561764489,0.0510982390297863,FALSE +"GSE12790","Pearson.est","adrenergic receptor antagonist",0.3795,0.919,0.561,226,0.853,"practolol, oxprenolol, dihydroergocristine, metoprolol",0.251037138743839,0.069050968832477,FALSE +"GSE12790","Pearson.est","AKT inhibitor",0.52174,1.27,0.191,322,0.628,"ONC201, GSK2110183, GDC.0068, MK.2206, uprosertib, palomid.529",0.718966632752272,0.202040356262804,FALSE +"GSE12790","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.48325,-1.27,0.177,1322,0.567,"AP26113, NVP.TAE684, brigatinib, GW.788388",0.752026733638193,0.246416941107093,FALSE +"GSE12790","Pearson.est","androgen receptor antagonist",0.34072,0.839,0.663,608,0.933,"enzalutamide, flutamide, nilutamide, RU.58841",0.178486471595227,0.0301183562535,FALSE +"GSE12790","Pearson.est","antioxidant",0.38019,0.943,0.511,301,0.858,"benfotiamine, trolox",0.291579099865287,0.0665127121512946,FALSE +"GSE12790","Pearson.est","AP inhibitor",-0.25432,-0.693,0.836,1096,0.922,"LCL.161, birinapant, GDC.0152",0.0777937225609836,0.0352690789463706,FALSE +"GSE12790","Pearson.est","ATPase inhibitor",0.26548,0.659,0.883,485,0.921,"oligomycin.a, digoxin, rabeprazole, blebbistatin...., evodiamine, NMS.873",0.0540392964224314,0.0357403698031511,FALSE +"GSE12790","Pearson.est","Aurora kinase inhibitor",0.46741,1.16,0.285,442,0.708,"CCT137690, PHA.680632, AT.9283, SNS.314, ZM.447439, barasertib, barasertib.HQPA, CCT129202, AMG900, aurora.a.inhibitor.i",0.54515513999149,0.149966742310231,FALSE +"GSE12790","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.20764,-0.569,0.962,299,0.946,"valnemulin, azalomycin.b, radezolid, tilmicosin, josamycin, dirithromycin, azithromycin, tedizolid",0.0168249279621871,0.0241088635982073,FALSE +"GSE12790","Pearson.est","bacterial DNA gyrase inhibitor",0.28154,0.682,0.806,233,0.932,"nadifloxacin, norfloxacin",0.0936649581949093,0.0305840876460186,FALSE +"GSE12790","Pearson.est","BCL inhibitor",0.47477,1.16,0.28,493,0.708,"gossypol, TW.37, venetoclax, ABT.737, oridonin",0.552841968657781,0.149966742310231,FALSE +"GSE12790","Pearson.est","Bcr.Abl kinase inhibitor",-0.70404,-1.86,0.0148,1270,0.0754,"metatinib, GZD824, bosutinib, ponatinib, dasatinib",1.82973828460504,1.12262865413023,TRUE +"GSE12790","Pearson.est","benzodiazepine receptor agonist",0.34409,0.844,0.656,602,0.949,"zaleplon, ZK.93423, lorazepam, nefiracetam, eprinomectin, temazepam, gamma.aminobutyric.acid, piperazine",0.18309616062434,0.0227337875727074,FALSE +"GSE12790","Pearson.est","bromodomain inhibitor",0.87421,2.16,0,81,0.00308,"I.BET151, PFI.1, OTX015, JQ1...., bromosporine",Inf,2.51144928349956,TRUE +"GSE12790","Pearson.est","calcium channel blocker",0.45908,1.12,0.309,449,0.739,"fendiline, tetrandrine, carboxyamidotriazole, SR.33805, mibefradil",0.510041520575165,0.131355561605174,FALSE +"GSE12790","Pearson.est","CC chemokine receptor antagonist",0.42896,1.05,0.383,518,0.867,"PF.04136309, ZK811752, UNBS.5162, MK.0812",0.416801226031377,0.0619809025237897,FALSE +"GSE12790","Pearson.est","CDK inhibitor",0.30255,0.741,0.777,162,0.955,"arcyriaflavin.a, NU6027, TG.02, abemaciclib, kenpaullone",0.109578981199086,0.0199966284162537,FALSE +"GSE12790","Pearson.est","CHK inhibitor",-0.86081,-2.27,0,1341,0.0143,"CHIR.124, AZD7762, LY2603618, SCH.900776, LY2606368",Inf,1.84466396253494,TRUE +"GSE12790","Pearson.est","cyclooxygenase inhibitor",0.49159,1.21,0.272,217,0.66,"naproxen, meloxicam, tepoxalin, piroxicam, sulfasalazine, pterostilbene, FR.122047",0.565431095965801,0.180456064458131,FALSE +"GSE12790","Pearson.est","cytochrome P450 inhibitor",0.32499,0.809,0.709,124,0.936,"cobicistat",0.149353764816933,0.0287241512618947,FALSE +"GSE12790","Pearson.est","DNA alkylating agent",0.35347,0.848,0.652,529,0.967,"dianhydrogalactitol, TH.302, mitomycin.c, melphalan, satraplatin, carmustine, streptozotocin, carboplatin",0.18575240426808,0.0145735259169983,FALSE +"GSE12790","Pearson.est","DNA inhibitor",0.59916,1.48,0.0774,339,0.474,"pibenzimol, mechlorethamine, chlorambucil, bendamustine, oxaliplatin, tirapazamine, melphalan, primaquine, valrubicin",1.11125903931711,0.324221658325915,FALSE +"GSE12790","Pearson.est","DNA methyltransferase inhibitor",-0.30427,-0.788,0.724,1288,0.925,"azacitidine, decitabine",0.140261433802853,0.0338582672609674,FALSE +"GSE12790","Pearson.est","DNA polymerase inhibitor",0.54988,1.36,0.137,60,0.679,"famciclovir, idoxuridine",0.863279432843593,0.168130225719498,FALSE +"GSE12790","Pearson.est","DNA synthesis inhibitor",0.28992,0.709,0.819,341,0.936,"azodicarbonamide, artemisinin, mitomycin.c, enocitabine, artesunate, CB.10.277",0.0867160982395816,0.0287241512618947,FALSE +"GSE12790","Pearson.est","dopamine receptor antagonist",0.25736,0.625,0.906,475,0.918,"nemonapride, UH.232...., sertindole, lurasidone, amisulpride, paliperidone, remoxipride",0.0428718023231869,0.0371573187987575,FALSE +"GSE12790","Pearson.est","estrogen receptor agonist",-0.34653,-0.935,0.499,499,0.974,"equol, estrone, ethinyl.estradiol, estradiol, PPT, erteberel, estradiol.cypionate, levonorgestrel",0.30189945437661,0.0114410431213845,FALSE +"GSE12790","Pearson.est","estrogen receptor antagonist",0.64005,1.55,0.0616,354,0.421,"fulvestrant, toremifene, danazol",1.21041928783557,0.375717904164332,FALSE +"GSE12790","Pearson.est","FGFR inhibitor",0.27439,0.675,0.851,389,0.921,"nintedanib, orantinib, regorafenib, dovitinib",0.0700704399154121,0.0357403698031511,FALSE +"GSE12790","Pearson.est","FLT3 inhibitor",0.39322,0.973,0.47,303,0.852,"TG.101348, TG.02, sorafenib, GTP.14564, pacritinib, quizartinib",0.327902142064283,0.0695604052332999,FALSE +"GSE12790","Pearson.est","glucocorticoid receptor agonist",0.31067,0.767,0.745,627,0.959,"halcinonide, rimexolone, deflazacort, beclomethasone.dipropionate, prednisolone, fluticasone.propionate, triamcinolone, clobetasol.propionate, difluprednate, halobetasol.propionate, ciclesonide, dexamethasone.acetate, methylprednisolone, flumethasone.pivalate",0.127843727251707,0.0181813928293364,FALSE +"GSE12790","Pearson.est","glutamate receptor antagonist",0.39642,0.981,0.488,156,0.893,"ACDPP, IEM1754, CPP",0.311580177997289,0.0491485411114536,FALSE +"GSE12790","Pearson.est","glycogen synthase kinase inhibitor",0.50565,1.23,0.239,463,0.651,"kenpaullone, CHIR.99021, AZD2858, GSK.3.inhibitor.IX",0.621602099051862,0.186419011431808,FALSE +"GSE12790","Pearson.est","growth factor receptor inhibitor",-0.48176,-1.28,0.207,1082,0.61,"AZD3463, GSK1838705A, GSK1904529A, lestaurtinib, PHA.848125",0.684029654543082,0.214670164989233,FALSE +"GSE12790","Pearson.est","HCV inhibitor",0.51816,1.27,0.197,403,0.628,"narlaprevir, embelin, mericitabine",0.705533773838407,0.202040356262804,FALSE +"GSE12790","Pearson.est","HDAC inhibitor",0.55627,1.39,0.134,365,0.657,"PCI.24781, M.344, dacinostat, entinostat, SB.939, RG2833, R306465, scriptaid, RGFP966, givinostat, AR.42, ACY.1215, resminostat, trichostatin.a",0.872895201635192,0.182434630440219,FALSE +"GSE12790","Pearson.est","histamine receptor antagonist",0.19855,0.495,0.976,351,0.98,"ICI.162846, cyproheptadine, epinastine, lafutidine",0.0105501823333082,0.00877392430750515,FALSE +"GSE12790","Pearson.est","HMGCR inhibitor",-0.35229,-0.907,0.543,508,0.822,"simvastatin, atorvastatin, mevastatin, lovastatin, pitavastatin, fluvastatin",0.265200170411153,0.0851281824599496,FALSE +"GSE12790","Pearson.est","HSP inhibitor",-0.71686,-1.9,0.0135,1227,0.0806,"KW.2478, VER.49009, alvespimycin, XL888, PU.H71, SNX.5422, NVP.AUY922, ganetespib, BIIB021",1.86966623150499,1.09366495819491,TRUE +"GSE12790","Pearson.est","JAK inhibitor",0.28069,0.695,0.839,278,0.935,"TG.101348, TG.02, AT.9283, pacritinib",0.0762380391712997,0.0291883891274822,FALSE +"GSE12790","Pearson.est","KIT inhibitor",-0.35009,-0.918,0.52,1380,0.894,"cediranib, dasatinib",0.283996656365201,0.0486624812040823,FALSE +"GSE12790","Pearson.est","MDM inhibitor",0.88974,2.14,0,165,0.00205,"nutlin.3, CGM097, idasanutlin, RITA, AMG.232, serdemetan",Inf,2.68824613894425,TRUE +"GSE12790","Pearson.est","MEK inhibitor",-0.73195,-1.95,0.00798,1344,0.0977,"PD.0325901, PD.184352, Ro.4987655, AS.703026, TAK.733, cobimetinib, PD.318088, selumetinib, refametinib, AZD8330, trametinib",2.09799710864927,1.01010543628123,TRUE +"GSE12790","Pearson.est","MET inhibitor",-0.61626,-1.62,0.0528,1352,0.201,"PF.04217903, INC.280, LY2801653",1.27736607746619,0.696803942579511,FALSE +"GSE12790","Pearson.est","microtubule inhibitor",-0.42511,-1.11,0.329,1042,0.705,"vinflunine, colchicine, estramustine.phosphate, vinblastine, cabazitaxel, podophyllotoxin, cytochalasin.b",0.482804102050026,0.151810883008601,FALSE +"GSE12790","Pearson.est","mTOR inhibitor",0.39439,0.99,0.453,401,0.904,"WYE.125132, LY303511, PI.103, PKI.179, deforolimus, ku.0063794, WYE.354, palomid.529, torin.2, XL388, torin.1",0.343901797987168,0.0438315695246367,FALSE +"GSE12790","Pearson.est","NFkB pathway inhibitor",0.32301,0.796,0.728,77,0.935,"tyloxapol, EVP4593",0.137868620686963,0.0291883891274822,FALSE +"GSE12790","Pearson.est","opioid receptor agonist",-0.35735,-0.968,0.482,1257,0.962,"spiradoline, ADL5859",0.31695296176115,0.0168249279621871,FALSE +"GSE12790","Pearson.est","p38 MAPK inhibitor",0.25948,0.638,0.892,399,0.924,"SB.242235, skepinone.l",0.0496351456238769,0.0343280287798933,FALSE +"GSE12790","Pearson.est","PARP inhibitor",0.54017,1.32,0.153,146,0.68,"PJ.34, AZD2461, AG.14361",0.815308569182401,0.167491087293764,FALSE +"GSE12790","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.24526,-0.665,0.893,1291,0.891,"CP.673451, SU014813, ponatinib, dasatinib",0.0491485411114536,0.0501222959631252,FALSE +"GSE12790","Pearson.est","phosphatase inhibitor",0.4579,1.14,0.325,366,0.723,"GSK2830371, mycophenolate.mofetil, CID.5458317, AS.1949490",0.488116639021126,0.140861702705469,FALSE +"GSE12790","Pearson.est","phosphodiesterase inhibitor",-0.34456,-0.916,0.523,1136,0.849,"papaverine, anagrelide, zardaverine, YM.976",0.281498311132726,0.0710923097560473,FALSE +"GSE12790","Pearson.est","PI3K inhibitor",0.29997,0.76,0.771,239,0.947,"YM.201636, LY303511, CUDC.907, PI.103, PKI.179, BGT226",0.112945621949043,0.0236500209967266,FALSE +"GSE12790","Pearson.est","PLK inhibitor",-0.43132,-1.13,0.313,1025,0.724,"BI.2536, GW.843682X, NMS.1286937, GSK461364, rigosertib",0.504455662453552,0.140261433802853,FALSE +"GSE12790","Pearson.est","potassium channel blocker",0.5208,1.3,0.189,151,0.682,"oleoylethanolamide",0.723538195826756,0.166215625343521,FALSE +"GSE12790","Pearson.est","PPAR receptor agonist",0.62978,1.53,0.0661,227,0.408,"GW.501516, oleoylethanolamide, ciprofibrate, pterostilbene, clofibrate",1.17979854051436,0.38933983691012,FALSE +"GSE12790","Pearson.est","progesterone receptor agonist",-0.30025,-0.798,0.694,1335,0.95,"levonorgestrel, dienogest",0.158640529545145,0.0222763947111523,FALSE +"GSE12790","Pearson.est","proteasome inhibitor",0.41098,1.01,0.429,43,0.924,"MG.132, oprozomib",0.367542707815276,0.0343280287798933,FALSE +"GSE12790","Pearson.est","protein synthesis inhibitor",0.39942,0.998,0.458,167,0.918,"clofoctol, azomycin..2.nitroimidazole., mercaptopurine, anguidine",0.339134521996131,0.0371573187987575,FALSE +"GSE12790","Pearson.est","protein tyrosine kinase inhibitor",-0.25697,-0.678,0.814,1248,0.907,"AV.412, NVP.TAE226, PP.121",0.0893755951107988,0.0423927129399047,FALSE +"GSE12790","Pearson.est","RAF inhibitor",0.39016,0.955,0.5,465,0.861,"sorafenib, TAK.632, regorafenib, GDC.0879, PLX.4720",0.301029995663981,0.0649968485463452,FALSE +"GSE12790","Pearson.est","RET tyrosine kinase inhibitor",0.3907,0.974,0.468,521,0.878,"sorafenib, apatinib, regorafenib, sunitinib, cabozantinib",0.329754146925876,0.0565054840938974,FALSE +"GSE12790","Pearson.est","retinoid receptor agonist",0.70735,1.74,0.0137,117,0.128,"fenretinide, adapalene, bexarotene, adarotene",1.86327943284359,0.892790030352132,TRUE +"GSE12790","Pearson.est","ribonucleotide reductase inhibitor",0.37557,0.937,0.511,161,0.844,"pentostatin, cladribine",0.291579099865287,0.073657553374345,FALSE +"GSE12790","Pearson.est","serotonin receptor agonist",0.29677,0.736,0.789,330,0.941,"aripiprazole, NAN.190",0.10292299679058,0.0264103765727431,FALSE +"GSE12790","Pearson.est","serotonin receptor antagonist",0.33278,0.825,0.652,412,0.932,"SB.200646, aripiprazole, sertindole, lurasidone, paliperidone",0.18575240426808,0.0305840876460186,FALSE +"GSE12790","Pearson.est","sodium channel blocker",0.49736,1.24,0.218,305,0.663,"cibenzoline, butamben, benzethonium, triamterene, quinidine, ajmaline",0.661543506395395,0.178486471595227,FALSE +"GSE12790","Pearson.est","src inhibitor",-0.71939,-1.92,0.013,1262,0.0907,"PP.1, bosutinib, ZM.306416, saracatinib, dasatinib",1.88605664769316,1.0423927129399,TRUE +"GSE12790","Pearson.est","sterol demethylase inhibitor",0.73519,1.84,0.00315,216,0.0747,"posaconazole, ketoconazole, chlormidazole",2.5016894462104,1.1266793981846,TRUE +"GSE12790","Pearson.est","TGF beta receptor inhibitor",-0.28251,-0.736,0.797,1403,0.895,"repsox",0.0985416786038876,0.048176964684088,FALSE +"GSE12790","Pearson.est","thymidylate synthase inhibitor",0.30094,0.729,0.802,222,0.93,"doxifluridine, ftorafur",0.0958256317158365,0.0315170514460649,FALSE +"GSE12790","Pearson.est","topoisomerase inhibitor",-0.34473,-0.924,0.519,1189,0.937,"fleroxacin, teniposide, topotecan, rubitecan, etoposide, camptothecin, irinotecan, SN.38, exatecan.mesylate",0.284832642151542,0.0282604091122217,FALSE +"GSE12790","Pearson.est","tubulin polymerization inhibitor",-0.46865,-1.24,0.231,1065,0.569,"indibulin, vindesine, flubendazole, dolastatin.10, verubulin, vinblastine, epothilone.d, nocodazole, podophyllotoxin, BNC105, parbendazole, epothilone.b, docetaxel, paclitaxel",0.636388020107856,0.244887733604929,FALSE +"GSE12790","Pearson.est","tyrosine kinase inhibitor",-0.33435,-0.885,0.573,1248,0.823,"AV.412, NVP.TAE226, aminopurvalanol.a, PP.121, vandetanib, tivantinib, dasatinib",0.24184537803261,0.0846001647877302,FALSE +"GSE12790","Pearson.est","VEGFR inhibitor",-0.27844,-0.748,0.795,1183,0.913,"MK.2461, foretinib, RAF265, lucitanib, SU014813, ZM.306416, cediranib, vandetanib, BMS.690514, XL.647",0.0996328713435297,0.039529222465701,FALSE +"GSE12790","Pearson.est","vitamin D receptor agonist",0.71974,1.74,0.0147,296,0.128,"tacalcitol, alfacalcidol, doxercalciferol, ercalcitriol, paricalcitol",1.83268266525182,0.892790030352132,TRUE +"GSE31625","Pearson.est","EGFR inhibitor",-0.84531,-2.17,0,1335,0.0275,"CP.724714, rociletinib, brigatinib, PD.153035, BMS.599626, TAK.285, BIBU.1361, WZ8040, AEE788, AST.1306, GW.583340, CUDC.101, vandetanib, BIBX.1382, ARRY.334543, PD.168393, icotinib, erlotinib, BMS.690514, pelitinib, gefitinib, tucatinib, lapatinib, neratinib, XL.647, afatinib, osimertinib, dacomitinib, AZD8931, canertinib, poziotinib",Inf,1.56066730616974,TRUE +"GSE31625","Pearson.est","Abl kinase inhibitor",0.44648,1.08,0.363,166,0.653,"nilotinib, ponatinib, KW.2449, GZD824, tozasertib, bafetinib",0.440093374963888,0.185086818724926,FALSE +"GSE31625","Pearson.est","acetylcholine receptor agonist",0.45634,1.1,0.378,556,0.638,"oxiracetam, tremorine, nefiracetam",0.422508200162775,0.195179321278838,FALSE +"GSE31625","Pearson.est","acetylcholine receptor antagonist",0.29578,0.718,0.809,658,0.894,"methscopolamine, diphemanil, iododexetimide",0.0920514783877277,0.0486624812040823,FALSE +"GSE31625","Pearson.est","adenosine receptor antagonist",-0.47253,-1.21,0.228,1392,0.705,"MRS.1220, CGS.15943",0.642065152999546,0.151810883008601,FALSE +"GSE31625","Pearson.est","adrenergic receptor agonist",-0.2496,-0.647,0.859,1121,0.995,"A61603, midodrine, methyldopa, ritodrine, terbutaline, xylazine",0.0660068361687577,0.00217691925427455,FALSE +"GSE31625","Pearson.est","adrenergic receptor antagonist",0.22766,0.553,0.96,168,0.992,"carvedilol, oxprenolol, atipamezole",0.0177287669604316,0.00348832784582135,FALSE +"GSE31625","Pearson.est","AKT inhibitor",-0.67949,-1.75,0.0274,1302,0.199,"AZD5363, GSK2110183, CCT128930, uprosertib, GDC.0068, triciribine",1.56224943717961,0.701146923590293,TRUE +"GSE31625","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.44688,-1.13,0.316,1245,0.815,"NVP.TAE684, AP26113, SB.505124, brigatinib, GW.788388",0.500312917381596,0.0888423912600234,FALSE +"GSE31625","Pearson.est","androgen receptor antagonist",0.47365,1.15,0.31,765,0.64,"nilutamide, bicalutamide, cyproterone.acetate, enzalutamide, RU.58841, flutamide",0.508638306165727,0.193820026016113,FALSE +"GSE31625","Pearson.est","antioxidant",0.64967,1.56,0.0371,395,0.399,"trolox, benfotiamine, taurine, mesna",1.43062609038495,0.399027104313252,FALSE +"GSE31625","Pearson.est","AP inhibitor",0.40862,0.999,0.455,45,0.692,"idronoxil",0.341988603342888,0.159893905543242,FALSE +"GSE31625","Pearson.est","ATPase inhibitor",0.52532,1.26,0.211,397,0.547,"digoxin, digitoxin, blebbistatin...., digitoxigenin, ouabain, oligomycin.a, evodiamine",0.675717544702307,0.262012673666569,FALSE +"GSE31625","Pearson.est","Aurora kinase inhibitor",0.51432,1.24,0.22,422,0.56,"AMG900, barasertib, KW.2449, AT.9283, tozasertib, SNS.314, PF.03814735, ENMD.2076, CCT137690, MK.8745, MK.5108, hesperadin, CCT129202",0.657577319177794,0.2518119729938,FALSE +"GSE31625","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.27431,-0.703,0.801,395,0.99,"valnemulin, radezolid, azalomycin.b, dirithromycin, tilmicosin, azithromycin, tedizolid, josamycin",0.0963674839157623,0.00436480540245009,FALSE +"GSE31625","Pearson.est","bacterial DNA gyrase inhibitor",-0.36959,-0.963,0.459,1094,1,"sarafloxacin, sparfloxacin, lomefloxacin, trovafloxacin",0.338187314462739,0,FALSE +"GSE31625","Pearson.est","BCL inhibitor",0.39553,0.956,0.521,604,0.689,"TW.37, venetoclax, gossypol, oridonin, ABT.737",0.283162276700476,0.161780778092374,FALSE +"GSE31625","Pearson.est","Bcr.Abl kinase inhibitor",0.51193,1.23,0.222,166,0.554,"nilotinib, ponatinib, GZD824, tozasertib, bafetinib",0.653647025549361,0.25649023527157,FALSE +"GSE31625","Pearson.est","benzodiazepine receptor agonist",-0.229,-0.583,0.915,1389,0.993,"CL.218872",0.0385789059335517,0.00305075150461883,FALSE +"GSE31625","Pearson.est","bromodomain inhibitor",-0.34455,-0.908,0.55,1138,0.905,"JQ1...., I.BET151, OTX015",0.259637310505756,0.0433514207947967,FALSE +"GSE31625","Pearson.est","calcium channel blocker",-0.30207,-0.754,0.747,1256,1,"SKF.96365, fendiline, efonidipine.monoethanolate",0.126679398184601,0,FALSE +"GSE31625","Pearson.est","CC chemokine receptor antagonist",0.52412,1.27,0.18,316,0.591,"navarixin, PF.04136309, UNBS.5162",0.744727494896694,0.228412519118745,FALSE +"GSE31625","Pearson.est","CDK inhibitor",0.4626,1.11,0.355,131,0.641,"abemaciclib, palbociclib, ribociclib, R547, PHA.848125, NU6027",0.449771646944906,0.193141970481183,FALSE +"GSE31625","Pearson.est","CHK inhibitor",-0.2304,-0.58,0.929,332,0.963,"SB.218078, SCH.900776, CHIR.124, PF.477736, AZD7762, LY2606368, LY2603618",0.0319842860063582,0.0163737128754655,FALSE +"GSE31625","Pearson.est","cyclooxygenase inhibitor",0.21335,0.505,0.981,455,0.996,"tepoxalin, suxibuzone, meloxicam, ketoprofen, indoprofen, FR.122047, naproxen",0.0083309926200515,0.00174066157630127,FALSE +"GSE31625","Pearson.est","cytochrome P450 inhibitor",-0.25746,-0.663,0.854,371,1,"metyrapone, morin, cobicistat, clotrimazole, PF.4981517, itraconazole, eplerenone",0.068542129310995,0,FALSE +"GSE31625","Pearson.est","DNA alkylating agent",0.5266,1.28,0.199,235,0.645,"mitomycin.c, carboplatin, melphalan, dianhydrogalactitol, TH.302, carmustine",0.701146923590293,0.190440285364732,FALSE +"GSE31625","Pearson.est","DNA inhibitor",0.59716,1.45,0.0953,240,0.565,"carboplatin, mechlorethamine, melphalan, pibenzimol, chlorambucil, teroxirone, oxaliplatin, carmustine, valrubicin",1.02090709936167,0.247951552180562,FALSE +"GSE31625","Pearson.est","DNA methyltransferase inhibitor",-0.63003,-1.63,0.0524,1376,0.293,"decitabine, azacitidine, SGI.1027",1.28066871301627,0.533132379645891,FALSE +"GSE31625","Pearson.est","DNA polymerase inhibitor",-0.38024,-0.957,0.469,1282,0.959,"cidofovir, menadione, cephalomannine",0.328827157284917,0.0181813928293364,FALSE +"GSE31625","Pearson.est","DNA synthesis inhibitor",0.57445,1.4,0.106,249,0.577,"mitomycin.c, floxuridine, anisomycin, cyclocytidine, azodicarbonamide, nelarabine",0.97469413473523,0.238824186844269,FALSE +"GSE31625","Pearson.est","dopamine receptor antagonist",0.3309,0.805,0.693,280,0.813,"amisulpride, paliperidone, raclopride, UH.232...., thioproperazine",0.159266765388193,0.0899094544059319,FALSE +"GSE31625","Pearson.est","estrogen receptor agonist",-0.5073,-1.3,0.196,1380,0.593,"erteberel, levonorgestrel",0.707743928643524,0.226945306635737,FALSE +"GSE31625","Pearson.est","estrogen receptor antagonist",-0.39305,-1,0.447,1232,0.989,"raloxifene, tamoxifen, clomifene",0.349692476868064,0.0048037084028206,FALSE +"GSE31625","Pearson.est","FGFR inhibitor",0.58015,1.42,0.111,149,0.582,"erdafitinib, dovitinib, regorafenib, nintedanib",0.954677021213343,0.235077015350112,FALSE +"GSE31625","Pearson.est","FLT3 inhibitor",0.66301,1.61,0.0414,348,0.348,"TG.101348, dovitinib, ponatinib, KW.2449, tozasertib, sorafenib, ENMD.2076, midostaurin, quizartinib, sunitinib, lestaurtinib",1.3829996588791,0.458420756053419,FALSE +"GSE31625","Pearson.est","glucocorticoid receptor agonist",-0.33377,-0.865,0.608,997,0.95,"fluocinolone.acetonide, fludroxycortide, halcinonide, dexamethasone.acetate, flumethasone.pivalate, betamethasone, methylprednisolone, desonide, fluorometholone, ciclesonide, flumethasone, hydrocortisone, piretanide, clobetasol.propionate, triamcinolone.acetonide",0.216096420727265,0.0222763947111523,FALSE +"GSE31625","Pearson.est","glutamate receptor antagonist",-0.15957,-0.424,0.995,1046,0.995,"kynurenic.acid, diazooxonorleucine, IEM1754, LY456236, CGP.37849",0.00217691925427455,0.00217691925427455,FALSE +"GSE31625","Pearson.est","glycogen synthase kinase inhibitor",-0.30507,-0.778,0.719,439,1,"CHIR.99021, GSK.3.inhibitor.IX, tideglusib, AZD2858, CHIR.98014, kenpaullone, TWS.119, indirubin, LY2090314",0.143271109617117,0,FALSE +"GSE31625","Pearson.est","growth factor receptor inhibitor",0.28378,0.699,0.839,692,0.899,"PHA.848125, lestaurtinib, AZD3463, danusertib, GSK1838705A",0.0762380391712997,0.0462403082667712,FALSE +"GSE31625","Pearson.est","HCV inhibitor",0.31913,0.782,0.733,294,0.828,"mericitabine, narlaprevir",0.134896025358872,0.0819696632151199,FALSE +"GSE31625","Pearson.est","HDAC inhibitor",0.40844,0.986,0.489,570,0.676,"entinostat, resminostat, M.344, scriptaid, RG2833, dacinostat, R306465, givinostat, trichostatin.a, chidamide, PCI.24781, RGFP966, NSC.3852, belinostat, vorinostat, panobinostat, AR.42",0.31069114087638,0.170053304058364,FALSE +"GSE31625","Pearson.est","histamine receptor antagonist",-0.40601,-1.02,0.435,1284,1,"ranitidine, terfenadine, levocetirizine, chloropyramine, ebastine",0.361510743045363,0,FALSE +"GSE31625","Pearson.est","HMGCR inhibitor",0.72086,1.72,0.0108,291,0.389,"mevastatin, fluvastatin, atorvastatin, pitavastatin, lovastatin",1.96657624451305,0.410050398674292,FALSE +"GSE31625","Pearson.est","HSP inhibitor",-0.50469,-1.3,0.181,1126,0.593,"SNX.5422, XL888, guanidine, VER.49009, alvespimycin, KW.2478",0.742321425130815,0.226945306635737,FALSE +"GSE31625","Pearson.est","JAK inhibitor",0.41465,1.02,0.456,465,0.676,"TG.101348, TG.101209, AT.9283, tozasertib, AZ960, lestaurtinib, TG.02, PRT062070",0.341035157335565,0.170053304058364,FALSE +"GSE31625","Pearson.est","KIT inhibitor",0.42953,1.03,0.427,311,0.702,"KI.8751, pazopanib, regorafenib, sorafenib, midostaurin, sunitinib",0.369572124974976,0.153662887870195,FALSE +"GSE31625","Pearson.est","MDM inhibitor",0.90266,2.2,0,48,0.000988,"idasanutlin, nutlin.3, AMG.232, CGM097, serdemetan",Inf,3.00524305541237,TRUE +"GSE31625","Pearson.est","MEK inhibitor",0.12876,0.304,1,1264,1,"U.0126, arctigenin, PD.98059, PD.198306, MEK162, PD.184352, cobimetinib, BIX.02188, PD.318088, refametinib, nobiletin, PD.0325901, selumetinib, MEK1.2.inhibitor, AS.703026, AZD8330, TAK.733, Ro.4987655, trametinib",0,0,FALSE +"GSE31625","Pearson.est","MET inhibitor",0.26741,0.64,0.876,418,0.944,"PHA.665752, AMG458, LY2801653",0.0574958938319193,0.025028005701931,FALSE +"GSE31625","Pearson.est","microtubule inhibitor",0.34468,0.844,0.649,288,0.773,"secnidazole, vinblastine, vinflunine",0.187755303199631,0.111820506081675,FALSE +"GSE31625","Pearson.est","mTOR inhibitor",0.39094,0.936,0.549,657,0.685,"ku.0063794, XL388, MLN0128, torin.1, AZD2014, LY303511, WAY.600, NVP.BEZ235, deforolimus, voxtalisib, LY3023414, SB.2343, AZD8055, PP242, PI.103, everolimus, WYE.125132, WYE.354, PKI.179, PF.04691502, temsirolimus",0.260427655549908,0.164309428507574,FALSE +"GSE31625","Pearson.est","NFkB pathway inhibitor",-0.31166,-0.804,0.705,1169,1,"parthenolide...., bindarit, IKK.2.inhibitor.V",0.151810883008601,0,FALSE +"GSE31625","Pearson.est","opioid receptor agonist",0.40666,0.971,0.498,494,0.682,"trimebutine, salvinorin.a, BW.180C",0.302770657240282,0.166215625343521,FALSE +"GSE31625","Pearson.est","p38 MAPK inhibitor",-0.35621,-0.937,0.487,1161,0.892,"CMPD.1, talmapimod, SB.239063",0.312471038785366,0.0496351456238769,FALSE +"GSE31625","Pearson.est","PARP inhibitor",0.53043,1.26,0.213,354,0.547,"talazoparib, AG.14361, PJ.34, olaparib",0.671620396561262,0.262012673666569,FALSE +"GSE31625","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.52424,1.29,0.208,219,0.664,"KI.8751, pazopanib, dovitinib, regorafenib, ponatinib, nintedanib, axitinib, sorafenib, crenolanib",0.681936665037238,0.177831920631982,FALSE +"GSE31625","Pearson.est","phosphatase inhibitor",0.53142,1.29,0.168,136,0.664,"bis.maltolato.oxovanadium.IV., GSK2830371, sodium.stibogluconate",0.774690718274137,0.177831920631982,FALSE +"GSE31625","Pearson.est","phosphodiesterase inhibitor",0.36337,0.869,0.614,114,0.753,"anagrelide, GSK256066",0.211831628858832,0.123205023799299,FALSE +"GSE31625","Pearson.est","PI3K inhibitor",-0.28147,-0.712,0.783,1240,1,"GSK2126458, TG100.115, TG.100713, CH5132799, alpelisib, PF.05212384, taselisib",0.106238237942057,0,FALSE +"GSE31625","Pearson.est","PLK inhibitor",0.71022,1.7,0.00636,289,0.302,"volasertib, rigosertib, GSK461364",2.19654288435159,0.519993057042849,FALSE +"GSE31625","Pearson.est","potassium channel blocker",0.47316,1.16,0.295,476,0.646,"meglitinide, ML133, ibutilide",0.530177984021837,0.189767482004916,FALSE +"GSE31625","Pearson.est","PPAR receptor agonist",0.56482,1.35,0.144,200,0.659,"GW.501516, clofibrate",0.84163750790475,0.18111458540599,FALSE +"GSE31625","Pearson.est","progesterone receptor agonist",0.4144,0.986,0.478,261,0.676,"norethindrone, tanaproget, danazol, nomegestrol.acetate",0.320572103387881,0.170053304058364,FALSE +"GSE31625","Pearson.est","proteasome inhibitor",-0.56749,-1.43,0.136,1091,0.484,"delanzomib, oprozomib, ixazomib.citrate, ONX.0914, carfilzomib",0.866461091629782,0.315154638355588,FALSE +"GSE31625","Pearson.est","protein synthesis inhibitor",0.43306,1.04,0.425,335,0.706,"mercaptopurine, homoharringtonine, anguidine, brefeldin.a, azomycin..2.nitroimidazole., cycloheximide, harringtonine",0.371611069949688,0.151195298948196,FALSE +"GSE31625","Pearson.est","protein tyrosine kinase inhibitor",-0.63562,-1.6,0.0597,1335,0.283,"CP.724714, BMS.599626, AV.412",1.22402566887063,0.54821356447571,FALSE +"GSE31625","Pearson.est","RAF inhibitor",0.69977,1.69,0.0174,277,0.245,"dabrafenib, regorafenib, vemurafenib, TAK.632, sorafenib, RAF265, LGX818, CEP.32496",1.7594507517174,0.610833915635468,TRUE +"GSE31625","Pearson.est","RET tyrosine kinase inhibitor",0.46899,1.14,0.298,311,0.632,"regorafenib, sorafenib, sunitinib",0.525783735923745,0.199282921717615,FALSE +"GSE31625","Pearson.est","retinoid receptor agonist",0.37196,0.888,0.606,155,0.742,"fenretinide, bexarotene",0.217527375833714,0.129596094720973,FALSE +"GSE31625","Pearson.est","ribonucleotide reductase inhibitor",0.62645,1.54,0.0461,344,0.385,"pentostatin, triapine, cladribine, fludarabine, clofarabine, fludarabine.phosphate, cytarabine",1.33629907461035,0.414539270491499,FALSE +"GSE31625","Pearson.est","serotonin receptor agonist",0.56624,1.34,0.138,158,0.629,"aripiprazole, NAN.190",0.860120913598763,0.201349354554731,FALSE +"GSE31625","Pearson.est","serotonin receptor antagonist",0.46356,1.12,0.314,346,0.646,"aripiprazole, SB.200646, paliperidone, pirenperone, SB.216641, lerisetron",0.503070351926785,0.189767482004916,FALSE +"GSE31625","Pearson.est","sodium channel blocker",-0.24824,-0.63,0.878,1320,0.981,"lappaconite, brivaracetam",0.0565054840938974,0.0083309926200515,FALSE +"GSE31625","Pearson.est","src inhibitor",-0.68109,-1.78,0.0264,1388,0.212,"bosutinib, dasatinib, ZM.306416, saracatinib",1.57839607313017,0.673664139071249,TRUE +"GSE31625","Pearson.est","sterol demethylase inhibitor",0.42226,1.02,0.449,484,0.676,"chlormidazole, posaconazole, ketoconazole, lanoconazole",0.347753658996677,0.170053304058364,FALSE +"GSE31625","Pearson.est","TGF beta receptor inhibitor",-0.70132,-1.81,0.00526,1213,0.238,"SB.431542, D.4476, LY2109761, repsox",2.27901425584626,0.623423042943488,TRUE +"GSE31625","Pearson.est","thymidylate synthase inhibitor",0.51743,1.27,0.202,503,0.591,"ftorafur, trifluridine, carmofur, raltitrexed",0.694648630553376,0.228412519118745,FALSE +"GSE31625","Pearson.est","topoisomerase inhibitor",0.50673,1.22,0.239,167,0.549,"nemorubicin, TAS.103, amsacrine, idarubicin, teniposide, voreloxin, amonafide, etoposide.phosphate, topotecan",0.621602099051862,0.260427655549908,FALSE +"GSE31625","Pearson.est","tubulin polymerization inhibitor",0.38582,0.943,0.538,265,0.692,"verubulin, BNC105, taltobulin, combretastatin.A.4, vinblastine, KX2.391, fosbretabulin",0.269217724333611,0.159893905543242,FALSE +"GSE31625","Pearson.est","tyrosine kinase inhibitor",-0.36966,-0.947,0.47,1311,0.924,"tivantinib, CP.724714, BMS.599626, dasatinib, vandetanib, AV.412",0.327902142064283,0.0343280287798933,FALSE +"GSE31625","Pearson.est","VEGFR inhibitor",-0.29988,-0.751,0.737,1394,0.993,"AEE788, vandetanib, ZM.306416, BMS.690514, XL.647",0.132532512140949,0.00305075150461883,FALSE +"GSE31625","Pearson.est","vitamin D receptor agonist",-0.75652,-1.94,0.0156,1122,0.149,"alfacalcidol, ercalcitriol, paricalcitol, tacalcitol, calcitriol, maxacalcitol",1.80687540164554,0.826813731587726,TRUE +"Coldren et al","Pearson.est","EGFR inhibitor",-0.82471,-2.37,0,1374,0.00409,"CUDC.101, AEE788, BIBU.1361, PD.153035, TAK.285, vandetanib, BIBX.1382, rociletinib, CP.724714, pelitinib, icotinib, GW.583340, WZ8040, erlotinib, afatinib, ARRY.334543, PD.168393, dacomitinib, gefitinib, XL.647, BMS.690514, neratinib, lapatinib, osimertinib, poziotinib, AZD8931, canertinib, tucatinib",Inf,2.38827669199266,TRUE +"Coldren et al","Pearson.est","Abl kinase inhibitor",0.60551,1.43,0.0642,225,0.314,"GZD824, KW.2449, ponatinib, tozasertib, flumatinib, nilotinib",1.19246497193115,0.503070351926785,FALSE +"Coldren et al","Pearson.est","acetylcholine receptor agonist",0.58097,1.39,0.0853,502,0.297,"oxiracetam, xanomeline, pilocarpine, tremorine",1.06905096883248,0.527243550682788,FALSE +"Coldren et al","Pearson.est","acetylcholine receptor antagonist",0.30262,0.728,0.808,803,0.991,"iododexetimide, methscopolamine, darifenacin",0.0925886392254138,0.00392634551472468,FALSE +"Coldren et al","Pearson.est","adenosine receptor antagonist",-0.55714,-1.6,0.04,1427,0.178,"MRS.1220, CGS.15943",1.39794000867204,0.749579997691106,TRUE +"Coldren et al","Pearson.est","adrenergic receptor agonist",-0.22191,-0.629,0.87,318,1,"buphenine, clenbuterol, oxymetazoline, midodrine, lidamidine, ritodrine, isoxsuprine, norepinephrine, isoetharine, terbutaline, metaraminol, epinephrine, A61603, methyldopa, xylazine",0.0604807473813815,0,FALSE +"Coldren et al","Pearson.est","adrenergic receptor antagonist",0.44946,1.07,0.383,525,0.666,"oxprenolol, idazoxan, atipamezole, carvedilol, naftidrofuryl, vincamine, levobunolol, metoprolol",0.416801226031377,0.176525770829699,FALSE +"Coldren et al","Pearson.est","AKT inhibitor",-0.58362,-1.69,0.0305,1336,0.209,"triciribine, CCT128930, GSK2110183, uprosertib, GDC.0068",1.51570016065321,0.679853713888946,TRUE +"Coldren et al","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.34351,0.82,0.725,148,0.932,"DMH1, AZD3463",0.139661993429006,0.0305840876460186,FALSE +"Coldren et al","Pearson.est","androgen receptor antagonist",0.60467,1.44,0.0778,480,0.34,"nilutamide, RU.58841, bicalutamide, cyproterone.acetate",1.10902040301031,0.468521082957745,FALSE +"Coldren et al","Pearson.est","antioxidant",0.51222,1.25,0.194,671,0.399,"trolox, mesna, chlorogenic.acid, benfotiamine, taurine",0.712198270069774,0.399027104313252,FALSE +"Coldren et al","Pearson.est","AP inhibitor",0.381,0.923,0.598,96,0.814,"idronoxil",0.223298816011589,0.0893755951107988,FALSE +"Coldren et al","Pearson.est","ATPase inhibitor",0.4364,1.07,0.376,323,0.666,"digoxin, evodiamine, blebbistatin...., ouabain, digitoxigenin, digitoxin",0.424812155072339,0.176525770829699,FALSE +"Coldren et al","Pearson.est","Aurora kinase inhibitor",0.62133,1.51,0.0419,251,0.35,"PF.03814735, AT.9283, barasertib, SNS.314, AMG900, KW.2449, hesperadin, danusertib, ENMD.2076, tozasertib, alisertib, GSK1070916, barasertib.HQPA",1.3777859770337,0.455931955649724,FALSE +"Coldren et al","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.3898,0.941,0.55,768,0.814,"valnemulin, radezolid, dirithromycin, azalomycin.b, tedizolid, tilmicosin",0.259637310505756,0.0893755951107988,FALSE +"Coldren et al","Pearson.est","bacterial DNA gyrase inhibitor",0.39298,0.956,0.498,198,0.801,"novobiocin, finafloxacin",0.302770657240282,0.0963674839157623,FALSE +"Coldren et al","Pearson.est","BCL inhibitor",0.57908,1.4,0.104,235,0.313,"TW.37, gossypol, venetoclax",0.98296666070122,0.504455662453552,FALSE +"Coldren et al","Pearson.est","Bcr.Abl kinase inhibitor",0.66348,1.58,0.0223,225,0.287,"GZD824, ponatinib, tozasertib, flumatinib, nilotinib",1.65169513695184,0.542118103266008,FALSE +"Coldren et al","Pearson.est","benzodiazepine receptor agonist",0.20268,0.489,0.989,596,0.999,"eprinomectin, zaleplon, temazepam, ivermectin, ZK.93423",0.0048037084028206,0.000434511774017692,FALSE +"Coldren et al","Pearson.est","bromodomain inhibitor",0.27519,0.666,0.893,800,0.989,"bromosporine, PFI.1, I.BET.762",0.0491485411114536,0.0048037084028206,FALSE +"Coldren et al","Pearson.est","calcium channel blocker",0.27812,0.662,0.878,370,0.976,"carboxyamidotriazole, cinnarazine, pranidipine",0.0565054840938974,0.0105501823333082,FALSE +"Coldren et al","Pearson.est","CC chemokine receptor antagonist",0.5806,1.39,0.107,490,0.297,"UNBS.5162, SB.225002, navarixin, PF.04136309, RS.504393, MK.0812",0.97061622231479,0.527243550682788,FALSE +"Coldren et al","Pearson.est","CDK inhibitor",0.40186,0.98,0.491,406,0.77,"palbociclib, abemaciclib, AZD5438, PHA.848125, R547, indisulam, ribociclib, kenpaullone, JNJ.7706621, BMS.265246",0.308918507877032,0.113509274827518,FALSE +"Coldren et al","Pearson.est","CHK inhibitor",-0.33033,-0.947,0.451,476,0.698,"SB.218078, PF.477736, AZD7762, CHIR.124, SCH.900776, LY2606368, LY2603618",0.345823458122039,0.156144577376839,FALSE +"Coldren et al","Pearson.est","cyclooxygenase inhibitor",0.30161,0.72,0.828,580,0.983,"tepoxalin, piroxicam, indoprofen, suxibuzone, meloxicam, ketoprofen, phenazone, FR.122047",0.0819696632151199,0.00744648216786438,FALSE +"Coldren et al","Pearson.est","cytochrome P450 inhibitor",0.5096,1.25,0.188,413,0.399,"itraconazole, metyrapone, cobicistat, morin",0.72584215073632,0.399027104313252,FALSE +"Coldren et al","Pearson.est","DNA alkylating agent",0.52809,1.28,0.17,368,0.398,"melphalan, carboplatin, carmustine, streptozotocin, TH.302, temozolomide, mitomycin.c",0.769551078621726,0.400116927926312,FALSE +"Coldren et al","Pearson.est","DNA inhibitor",0.41865,1.02,0.434,638,0.738,"melphalan, valrubicin, carboplatin, carmustine, teroxirone, chlorambucil, oxaliplatin, nimorazole, tirapazamine, pibenzimol, mechlorethamine",0.362510270487489,0.131943638176958,FALSE +"Coldren et al","Pearson.est","DNA methyltransferase inhibitor",-0.36253,-1.08,0.354,1371,0.559,"azacitidine, SGI.1027",0.450996737974212,0.252588192113577,FALSE +"Coldren et al","Pearson.est","DNA polymerase inhibitor",0.60364,1.46,0.0678,236,0.325,"idoxuridine, trifluridine, foscarnet",1.16877030613294,0.488116639021126,FALSE +"Coldren et al","Pearson.est","DNA synthesis inhibitor",0.56425,1.34,0.127,373,0.339,"anisomycin, floxuridine, cyclocytidine, CB.10.277, azodicarbonamide, nelarabine, mitomycin.c, artesunate",0.896196279044043,0.469800301796918,FALSE +"Coldren et al","Pearson.est","dopamine receptor antagonist",0.36056,0.864,0.667,603,0.91,"raclopride, amisulpride, paliperidone, UH.232...., thioproperazine, isofloxythepin, sertindole, domperidone, mesoridazine",0.175874166083451,0.0409586076789064,FALSE +"Coldren et al","Pearson.est","estrogen receptor agonist",0.32797,0.799,0.729,640,0.928,"estrone, PPT, estradiol, ethinyl.estradiol",0.137272471682025,0.0324520237811379,FALSE +"Coldren et al","Pearson.est","estrogen receptor antagonist",0.33908,0.803,0.756,506,0.94,"fulvestrant, danazol",0.121478204498793,0.0268721464003014,FALSE +"Coldren et al","Pearson.est","FGFR inhibitor",0.50189,1.2,0.216,402,0.463,"dovitinib, regorafenib, erdafitinib, nintedanib, MK.2461",0.665546248849069,0.334419008982047,FALSE +"Coldren et al","Pearson.est","FLT3 inhibitor",0.63527,1.54,0.0347,392,0.326,"dovitinib, KW.2449, ponatinib, TG.101348, ENMD.2076, tozasertib, quizartinib, gilteritinib, midostaurin, sunitinib, lestaurtinib, sorafenib",1.45967052520913,0.486782399932061,FALSE +"Coldren et al","Pearson.est","glucocorticoid receptor agonist",0.16994,0.406,0.994,629,0.997,"fluticasone.propionate, prednisolone, hydrocortisone, rimexolone, fluocinolone.acetonide, halobetasol.propionate, triamcinolone, prednisolone.acetate",0.00261361560268669,0.00130484168834428,FALSE +"Coldren et al","Pearson.est","glutamate receptor antagonist",-0.4446,-1.32,0.15,638,0.396,"ACDPP, MTPG, diazooxonorleucine, SIB.1757, tiletamine, IEM1754, JNJ.16259685, CPP, latrepirdine, felbamate, kynurenic.acid, CGP.37849, LY456236",0.823908740944319,0.402304814074488,FALSE +"Coldren et al","Pearson.est","glycogen synthase kinase inhibitor",0.28675,0.691,0.854,430,0.999,"tideglusib, kenpaullone, TWS.119",0.068542129310995,0.000434511774017692,FALSE +"Coldren et al","Pearson.est","growth factor receptor inhibitor",0.6058,1.47,0.0558,388,0.332,"PHA.848125, danusertib, AZD3463, GSK1838705A, lestaurtinib",1.25336580106242,0.478861916295964,FALSE +"Coldren et al","Pearson.est","HCV inhibitor",0.52227,1.27,0.181,207,0.403,"narlaprevir, mericitabine",0.742321425130815,0.39469495385889,FALSE +"Coldren et al","Pearson.est","HDAC inhibitor",-0.43359,-1.22,0.208,617,0.437,"dacinostat, entinostat, belinostat, resminostat, RG2833, trichostatin.a, scriptaid, RGFP966, AR.42, NSC.3852, R306465, chidamide, givinostat, nexturastat.a, ACY.1215, PCI.24781, vorinostat, M.344, SB.939, panobinostat, pyroxamide, romidepsin, tacedinaline, JNJ.26481585, mocetinostat",0.681936665037238,0.359518563029578,FALSE +"Coldren et al","Pearson.est","histamine receptor antagonist",0.28671,0.684,0.868,658,0.989,"pheniramine, cimetidine, tiotidine, nizatidine, famotidine, zolantidine, ICI.162846, BF2.649, astemizole",0.0614802748235081,0.0048037084028206,FALSE +"Coldren et al","Pearson.est","HMGCR inhibitor",0.80486,1.95,0,104,0.0289,"fluvastatin, atorvastatin, mevastatin, pitavastatin",Inf,1.53910215724345,TRUE +"Coldren et al","Pearson.est","HSP inhibitor",0.42561,1.03,0.429,261,0.735,"SNX.2112, NVP.AUY922, NMS.E973, PU.H71, ganetespib",0.367542707815276,0.133712660915805,FALSE +"Coldren et al","Pearson.est","JAK inhibitor",0.46895,1.13,0.311,145,0.589,"AT.9283, AZ960, TG.101348, TG.101209, tozasertib",0.507239610973163,0.229884705212898,FALSE +"Coldren et al","Pearson.est","KIT inhibitor",0.41165,0.99,0.472,765,0.766,"KI.8751, regorafenib, pazopanib, OSI.930, midostaurin, sunitinib, sorafenib, masitinib, cediranib, tandutinib, motesanib, vatalanib, lenvatinib",0.326058001365912,0.115771230367396,FALSE +"Coldren et al","Pearson.est","MDM inhibitor",0.86919,2.1,0.00124,191,0.00577,"idasanutlin, nutlin.3, serdemetan, AMG.232, CGM097",2.90657831483776,2.23882418684427,TRUE +"Coldren et al","Pearson.est","MEK inhibitor",-0.29881,-0.858,0.649,427,0.803,"arctigenin, U.0126, PD.0325901, PD.318088, refametinib, nobiletin, AZD8330, Ro.4987655, TAK.733, cobimetinib, PD.184352, PD.198306, AS.703026, MEK162, selumetinib, PD.98059, MEK1.2.inhibitor, trametinib, BIX.02188",0.187755303199631,0.095284454721319,FALSE +"Coldren et al","Pearson.est","MET inhibitor",0.31428,0.763,0.796,238,0.964,"LY2801653, PHA.665752",0.0990869322623309,0.0159229660971692,FALSE +"Coldren et al","Pearson.est","microtubule inhibitor",0.74948,1.83,0.00369,249,0.0599,"vinblastine, vinflunine, secnidazole, podophyllotoxin, D.64131, cabazitaxel",2.43297363384094,1.22257317761069,TRUE +"Coldren et al","Pearson.est","mTOR inhibitor",0.35239,0.829,0.681,693,0.935,"ku.0063794, torin.1, AZD8055, NVP.BEZ235, WYE.354, MLN0128, WAY.600, PKI.179, deforolimus, XL388, LY3023414, AZD2014, palomid.529, PF.04691502, LY303511, voxtalisib, SB.2343",0.166852888087215,0.0291883891274822,FALSE +"Coldren et al","Pearson.est","NFkB pathway inhibitor",0.23578,0.567,0.948,549,1,"betulinic.acid, bortezomib, BAY.11.7082, EVP4593",0.0231916626619338,0,FALSE +"Coldren et al","Pearson.est","opioid receptor agonist",0.55941,1.34,0.133,466,0.339,"trimebutine, cebranopadol, salvinorin.a, spiradoline",0.876148359032914,0.469800301796918,FALSE +"Coldren et al","Pearson.est","p38 MAPK inhibitor",-0.30326,-0.856,0.634,437,0.753,"skepinone.l, SB.242235, VX.702, TAK.715, CMPD.1, SB.239063, talmapimod",0.197910742118267,0.123205023799299,FALSE +"Coldren et al","Pearson.est","PARP inhibitor",0.57655,1.4,0.0909,602,0.313,"talazoparib, AG.14361, niraparib, olaparib, E7449, PJ.34, AZD2461",1.04143611677803,0.504455662453552,FALSE +"Coldren et al","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.45968,1.12,0.31,392,0.593,"KI.8751, dovitinib, crenolanib, ponatinib, regorafenib, pazopanib, CP.673451, axitinib, nintedanib, sunitinib, sorafenib",0.508638306165727,0.226945306635737,FALSE +"Coldren et al","Pearson.est","phosphatase inhibitor",0.42138,1.01,0.445,522,0.743,"GSK2830371, bis.maltolato.oxovanadium.IV., sodium.stibogluconate, CID.5458317, BVT.948",0.351639989019068,0.129011186239425,FALSE +"Coldren et al","Pearson.est","phosphodiesterase inhibitor",0.35736,0.857,0.671,337,0.903,"GSK256066, anagrelide, YM.976",0.173277479831008,0.0443122496864942,FALSE +"Coldren et al","Pearson.est","PI3K inhibitor",-0.21553,-0.611,0.927,1367,0.977,"CH5132799, PF.05212384, alpelisib, taselisib",0.0329202658555029,0.0101054362812269,FALSE +"Coldren et al","Pearson.est","PLK inhibitor",0.73976,1.8,0.00244,382,0.0671,"rigosertib, volasertib, GSK461364, NMS.1286937, BI.2536, HMN.214, GW.843682X",2.61261017366127,1.17327747983101,TRUE +"Coldren et al","Pearson.est","potassium channel blocker",0.50069,1.2,0.252,726,0.463,"meglitinide, dofetilide, ML133, oleoylethanolamide, ibutilide, mepivacaine",0.598599459218456,0.334419008982047,FALSE +"Coldren et al","Pearson.est","PPAR receptor agonist",-0.43928,-1.3,0.148,633,0.372,"ciprofibrate, clofibrate, oleoylethanolamide, GW.501516, fenofibrate, S26948, pterostilbene",0.829738284605043,0.429457060118102,FALSE +"Coldren et al","Pearson.est","progesterone receptor agonist",0.21279,0.507,0.976,772,1,"tanaproget, danazol, nomegestrol.acetate, norethindrone, dienogest",0.0105501823333082,0,FALSE +"Coldren et al","Pearson.est","proteasome inhibitor",0.52318,1.25,0.177,369,0.399,"MG.132, ixazomib, bortezomib",0.752026733638193,0.399027104313252,FALSE +"Coldren et al","Pearson.est","protein synthesis inhibitor",0.58007,1.38,0.1,119,0.301,"mercaptopurine, anguidine, homoharringtonine, cycloheximide, brefeldin.a, harringtonine",1,0.521433504406157,FALSE +"Coldren et al","Pearson.est","protein tyrosine kinase inhibitor",-0.58296,-1.64,0.0233,1354,0.192,"BMS.599626, AV.412, CP.724714",1.63264407897398,0.71669877129645,TRUE +"Coldren et al","Pearson.est","RAF inhibitor",0.59544,1.43,0.065,526,0.314,"regorafenib, dabrafenib, SB.590885, GDC.0879, RAF265, vemurafenib, sorafenib, TAK.632, LGX818, CEP.32496, PLX.4720",1.18708664335714,0.503070351926785,FALSE +"Coldren et al","Pearson.est","RET tyrosine kinase inhibitor",0.39031,0.935,0.556,392,0.808,"regorafenib, sunitinib, sorafenib",0.254925208417942,0.0925886392254138,FALSE +"Coldren et al","Pearson.est","retinoid receptor agonist",-0.3375,-1,0.394,486,0.653,"adarotene, bexarotene, fenretinide, LE.135, tamibarotene, adapalene, AM.580, CD.437",0.404503778174426,0.185086818724926,FALSE +"Coldren et al","Pearson.est","ribonucleotide reductase inhibitor",0.65753,1.62,0.0286,394,0.252,"clofarabine, cladribine, triapine, fludarabine.phosphate, LY2334737, pentostatin, gemcitabine, fludarabine",1.54363396687096,0.598599459218456,FALSE +"Coldren et al","Pearson.est","serotonin receptor agonist",0.57158,1.4,0.0896,410,0.313,"aripiprazole, NAN.190, SR.57227A, ipsapirone",1.04769199033787,0.504455662453552,FALSE +"Coldren et al","Pearson.est","serotonin receptor antagonist",0.5316,1.29,0.149,460,0.395,"aripiprazole, SB.200646, paliperidone, lerisetron, pirenperone, SB.216641, sertindole",0.826813731587726,0.40340290437354,FALSE +"Coldren et al","Pearson.est","sodium channel blocker",0.27088,0.653,0.89,264,0.968,"butamben, quinidine, ajmaline",0.0506099933550872,0.0141246426916063,FALSE +"Coldren et al","Pearson.est","src inhibitor",-0.39641,-1.14,0.263,1412,0.51,"ZM.306416, saracatinib",0.580044251510242,0.292429823902064,FALSE +"Coldren et al","Pearson.est","sterol demethylase inhibitor",0.53593,1.3,0.165,619,0.392,"posaconazole, ketoconazole, chlormidazole, lanoconazole",0.782516055786094,0.406713932979543,FALSE +"Coldren et al","Pearson.est","TGF beta receptor inhibitor",-0.47357,-1.36,0.14,1362,0.399,"LY2109761, repsox",0.853871964321762,0.399027104313252,FALSE +"Coldren et al","Pearson.est","thymidylate synthase inhibitor",0.7991,1.93,0,189,0.0228,"trifluridine, raltitrexed, carmofur, ftorafur",Inf,1.64206515299955,TRUE +"Coldren et 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+ + + + diff --git a/Examples/Fig2/GSEA/GSEA_mean_results.csv b/Examples/Fig2/GSEA/GSEA_mean_results.csv new file mode 100644 index 0000000..ea6956a --- /dev/null +++ b/Examples/Fig2/GSEA/GSEA_mean_results.csv @@ -0,0 +1,187 @@ +"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",1.89,0.134536240470737,2.00471207292328e-05,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.0037287644556373 +"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",1.74,0.265141471671257,0.000240278884420519,"GSE12790, GSE31625, Coldren et al",3,0,"",0.0132556357325164 +"KEGG_FOLATE_BIOSYNTHESIS",1.72666666666667,0.485008590989204,0.000285067435107879,"GSE12790, GSE31625, Coldren et al",3,2,"GSE12790, GSE31625",0.0132556357325164 +"KEGG_SULFUR_METABOLISM",1.61,0.36592348927064,0.00246148439985586,"GSE12790, GSE31625, Coldren et al",3,0,"",0.0809457043004935 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+"KEGG_ECM_RECEPTOR_INTERACTION",1.41666666666667,0.370720020140986,0.015729245299059,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.152044767501969 +"KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",1.41333333333333,0.205020324195757,0.0264058915738126,"GSE12790, GSE31625, Coldren et al",3,0,"",0.196459833309166 +"KEGG_BLADDER_CANCER",1.35333333333333,0.205993527406405,0.0399686235833409,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.219324697141609 +"KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",1.35,0.563471383479232,0.00906084745066521,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.142671637050432 +"KEGG_DORSO_VENTRAL_AXIS_FORMATION",1.34666666666667,0.208166599946613,0.0301444056498553,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.202195220019937 +"KEGG_VIRAL_MYOCARDITIS",1.27533333333333,0.469217788807429,0.0450468667641184,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.239391920517886 +"KEGG_PRIMARY_IMMUNODEFICIENCY",1.266,0.556334431794402,0.0195921888040481,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.164054772359422 +"KEGG_AXON_GUIDANCE",1.25333333333333,0.0351188458428425,0.0799897160275239,"GSE12790, GSE31625, Coldren et al",3,0,"",0.303634432267744 +"KEGG_CELL_ADHESION_MOLECULES_CAMS",1.25333333333333,0.180092568789868,0.104439298993411,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226 +"KEGG_ADHERENS_JUNCTION",1.22333333333333,0.177857620959388,0.110966540335512,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226 +"KEGG_STEROID_BIOSYNTHESIS",1.21866666666667,0.514642918277648,0.0400325385329101,"GSE12790, GSE31625, Coldren et al",3,0,"",0.219324697141609 +"KEGG_BASAL_CELL_CARCINOMA",1.2,0.235159520326097,0.128523489430298,"GSE12790, GSE31625, Coldren et al",3,0,"",0.385570468290895 +"KEGG_PANCREATIC_CANCER",1.17533333333333,0.157306494886045,0.183904383166151,"GSE12790, GSE31625, Coldren et al",3,0,"",0.46857829135485 +"KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",1.17,0.158745078663875,0.181661009265945,"GSE12790, GSE31625, Coldren et al",3,0,"",0.46857829135485 +"KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",1.16266666666667,0.212417827249347,0.145105371928179,"GSE12790, GSE31625, Coldren et al",3,0,"",0.408933320888505 +"KEGG_THYROID_CANCER",1.15333333333333,0.0585946527708231,0.210692710652901,"GSE12790, GSE31625, Coldren et al",3,0,"",0.483941442378293 +"KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",1.14433333333333,0.368709009021116,0.167835218682395,"GSE12790, GSE31625, Coldren et al",3,0,"",0.446344530679348 +"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",1.14433333333333,0.238361769865332,0.208811902161077,"GSE12790, GSE31625, Coldren et al",3,0,"",0.483941442378293 +"KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",1.143,0.336492199018046,0.203041816453584,"GSE12790, GSE31625, Coldren et al",3,0,"",0.483941442378293 +"KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",1.13866666666667,0.232562536392544,0.210748692648611,"GSE12790, GSE31625, Coldren et al",3,0,"",0.483941442378293 +"KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",1.13666666666667,0.0723417813807023,0.198260408890443,"GSE12790, GSE31625, Coldren et al",3,0,"",0.483941442378293 +"KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",1.136,0.20136533961931,0.237393896128453,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982 +"KEGG_HEDGEHOG_SIGNALING_PATHWAY",1.12666666666667,0.132790561913614,0.283910492058359,"GSE12790, GSE31625, Coldren et al",3,0,"",0.502927157360522 +"KEGG_DRUG_METABOLISM_OTHER_ENZYMES",1.11666666666667,0.0923760430703401,0.25246493645276,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982 +"KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",1.11533333333333,0.135371094895969,0.268566576128902,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982 +"KEGG_ENDOCYTOSIS",1.11166666666667,0.31202296923998,0.226691824765323,"GSE12790, GSE31625, Coldren et al",3,0,"",0.484651487429311 +"KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",1.11,0.0624499799839839,0.274967811759291,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982 +"KEGG_FOCAL_ADHESION",1.10933333333333,0.356390703208338,0.222775911928715,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.484651487429311 +"KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",1.10766666666667,0.290644685713215,0.268619686982773,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982 +"KEGG_RENAL_CELL_CARCINOMA",1.10666666666667,0.0404145188432737,0.282430833550908,"GSE12790, GSE31625, Coldren et al",3,0,"",0.502927157360522 +"KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",1.09866666666667,0.14719148526098,0.314092356527521,"GSE12790, GSE31625, Coldren et al",3,0,"",0.540936836241841 +"KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",1.09166666666667,0.478443657428263,0.201069633171426,"GSE12790, GSE31625, Coldren et al",3,0,"",0.483941442378293 +"KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",1.089,0.386578581920934,0.167979124449217,"GSE12790, GSE31625, Coldren et al",3,0,"",0.446344530679348 +"KEGG_ERBB_SIGNALING_PATHWAY",1.079,0.0981478476585198,0.32900159989543,"GSE12790, GSE31625, Coldren et al",3,0,"",0.556311796186817 +"KEGG_PRION_DISEASES",1.07766666666667,0.437031272717792,0.242728872190082,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.496543815409982 +"KEGG_TIGHT_JUNCTION",1.07766666666667,0.100430738986295,0.364310331895039,"GSE12790, GSE31625, Coldren et al",3,0,"",0.589232362891106 +"KEGG_VEGF_SIGNALING_PATHWAY",1.06766666666667,0.141302276461964,0.334365174443668,"GSE12790, GSE31625, Coldren et al",3,0,"",0.560287589608308 +"KEGG_SMALL_CELL_LUNG_CANCER",1.06433333333333,0.446643407354607,0.192429310181635,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.483673671537623 +"KEGG_MELANOGENESIS",1.05266666666667,0.0916587875401662,0.413063528667972,"GSE12790, GSE31625, Coldren et al",3,0,"",0.64562870867431 +"KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",1.04666666666667,0.267644042215278,0.384586270820053,"GSE12790, GSE31625, Coldren et al",3,0,"",0.611393558739572 +"KEGG_LYSOSOME",1.046,0.425500881315186,0.221738213801101,"GSE12790, GSE31625, Coldren et al",3,0,"",0.484651487429311 +"KEGG_PATHWAYS_IN_CANCER",1.03966666666667,0.258612322470012,0.395430298344703,"GSE12790, GSE31625, Coldren et al",3,0,"",0.623305385526396 +"KEGG_NON_SMALL_CELL_LUNG_CANCER",1.03566666666667,0.0991682072709461,0.452408828960927,"GSE12790, GSE31625, Coldren et al",3,0,"",0.690739171349311 +"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",1.01733333333333,0.29438297052196,0.341410918164267,"GSE12790, GSE31625, Coldren et al",3,0,"",0.561968413969502 +"KEGG_GRAFT_VERSUS_HOST_DISEASE",1.00833333333333,1.50716897968786,0.106158461029819,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226 +"KEGG_ACUTE_MYELOID_LEUKEMIA",0.989333333333333,0.113847851685191,0.535177148549286,"GSE12790, GSE31625, Coldren et al",3,0,"",0.754142929012424 +"KEGG_NOTCH_SIGNALING_PATHWAY",0.988666666666667,0.16590760480862,0.539485694331938,"GSE12790, GSE31625, Coldren et al",3,0,"",0.754142929012424 +"KEGG_DILATED_CARDIOMYOPATHY",0.982333333333333,0.233097261531176,0.519599261253213,"GSE12790, GSE31625, Coldren et al",3,0,"",0.751654207965371 +"KEGG_GNRH_SIGNALING_PATHWAY",0.979333333333333,0.0323934149686836,0.603224772535707,"GSE12790, GSE31625, Coldren et al",3,0,"",0.818125076876376 +"KEGG_JAK_STAT_SIGNALING_PATHWAY",0.939666666666667,0.204808040206759,0.606996024779247,"GSE12790, GSE31625, Coldren et al",3,0,"",0.818125076876376 +"KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.932666666666667,0.127844958185035,0.678286709374389,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876120332941918 +"KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.905,0.0910659101969557,0.773013983421368,"GSE12790, GSE31625, Coldren et al",3,0,"",0.906726381613588 +"KEGG_ENDOMETRIAL_CANCER",0.903,0.182748461005832,0.716771256325571,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702 +"KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.895333333333333,0.207695289627216,0.697173771348368,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702 +"KEGG_GLIOMA",0.885666666666667,0.10646282606306,0.791073291064056,"GSE12790, GSE31625, Coldren et al",3,0,"",0.913910758620586 +"KEGG_P53_SIGNALING_PATHWAY",0.877333333333333,0.376988505571898,0.62067694485193,"GSE12790, GSE31625, Coldren et al",3,0,"",0.824613655303279 +"KEGG_ALLOGRAFT_REJECTION",0.875,1.47415229878056,0.0163488997313946,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.152044767501969 +"KEGG_TYPE_I_DIABETES_MELLITUS",0.867666666666667,1.47069586704163,0.00988435123753631,"GSE12790, GSE31625, Coldren et al",3,0,"",0.142671637050432 +"KEGG_WNT_SIGNALING_PATHWAY",0.862,0.175008571218669,0.818207332568072,"GSE12790, GSE31625, Coldren et al",3,0,"",0.929391833681316 +"KEGG_PROSTATE_CANCER",0.842333333333333,0.0884891707122026,0.885626587968505,"GSE12790, GSE31625, Coldren et al",3,0,"",0.96450577624571 +"KEGG_CHRONIC_MYELOID_LEUKEMIA",0.834,0.121786698781107,0.886723052354927,"GSE12790, GSE31625, Coldren et al",3,0,"",0.96450577624571 +"KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.62,1.43446854270144,0.0369570461523315,"GSE12790, GSE31625, Coldren et al",3,0,"",0.219324697141609 +"KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.601,1.26270067712027,0.136743686694518,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.397411339455942 +"KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.58,1.4992331373072,0.0211683577237964,"GSE12790, GSE31625, Coldren et al",3,0,"",0.164054772359422 +"KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.571666666666667,1.22724175830736,0.155619125860894,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.425664079560681 +"KEGG_PPAR_SIGNALING_PATHWAY",0.567,1.28177884207846,0.142609882551538,"GSE12790, GSE31625, Coldren et al",3,0,"",0.40808366391671 +"KEGG_GALACTOSE_METABOLISM",0.55,1.49438950745781,0.0304379901105281,"GSE12790, GSE31625, Coldren et al",3,0,"",0.202195220019937 +"KEGG_STARCH_AND_SUCROSE_METABOLISM",0.513666666666667,1.19216623561202,0.256415440665712,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982 +"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.513333333333333,1.46158589666613,0.0570145053646437,"GSE12790, GSE31625, Coldren et al",3,0,"",0.252821847442748 +"KEGG_ARACHIDONIC_ACID_METABOLISM",0.453333333333333,1.72743547877579,0.0132253486054393,"GSE12790, GSE31625, Coldren et al",3,0,"",0.147394735159805 +"KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.453333333333333,1.3539694728218,0.125895112542221,"GSE12790, GSE31625, Coldren et al",3,0,"",0.383876900538577 +"KEGG_PHENYLALANINE_METABOLISM",0.45,1.69858764860692,0.0134715618156811,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.147394735159805 +"KEGG_ASTHMA",0.436666666666667,1.43472413143898,0.108281501405106,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226 +"KEGG_TYPE_II_DIABETES_MELLITUS",0.436666666666667,1.2667412258758,0.259069929470746,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982 +"KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.433,1.16999529913586,0.369478090934058,"GSE12790, GSE31625, Coldren et al",3,0,"",0.592439007877024 +"KEGG_COLORECTAL_CANCER",0.427333333333333,0.880770306795894,0.85391474358544,"GSE12790, GSE31625, Coldren et al",3,0,"",0.943475518927392 +"KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.426666666666667,1.3146228863569,0.208269833147509,"GSE12790, GSE31625, Coldren et al",3,0,"",0.483941442378293 +"KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.423333333333333,1.43604781721687,0.094765876168384,"GSE12790, GSE31625, Coldren et al",3,0,"",0.345616724849401 +"KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.421666666666667,1.30125260166246,0.263984157613368,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982 +"KEGG_N_GLYCAN_BIOSYNTHESIS",0.411,1.21937401973308,0.339260323880508,"GSE12790, GSE31625, Coldren et al",3,0,"",0.561968413969502 +"KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.410333333333333,0.946689142925667,0.807194324849932,"GSE12790, GSE31625, Coldren et al",3,0,"",0.926778669272144 +"KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.406666666666667,1.15752077015202,0.453065477981806,"GSE12790, GSE31625, Coldren et al",3,0,"",0.690739171349311 +"KEGG_AUTOIMMUNE_THYROID_DISEASE",0.393333333333333,1.65714614121185,0.0124274102996564,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.147394735159805 +"KEGG_CALCIUM_SIGNALING_PATHWAY",0.386,1.0023537299776,0.775267514720685,"GSE12790, GSE31625, Coldren et al",3,0,"",0.906726381613588 +"KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.382,0.823634020666946,0.944062981274023,"GSE12790, GSE31625, Coldren et al",3,0,"",0.994611226804283 +"KEGG_APOPTOSIS",0.380333333333333,1.0007808617941,0.775572036929403,"GSE12790, GSE31625, Coldren et al",3,0,"",0.906726381613588 +"KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.377666666666667,0.946910942662156,0.857243885477039,"GSE12790, GSE31625, Coldren et al",3,0,"",0.943475518927392 +"KEGG_ETHER_LIPID_METABOLISM",0.376666666666667,1.42889234490683,0.116087052843398,"GSE12790, GSE31625, Coldren et al",3,0,"",0.359869863814534 +"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.375,1.12204055185185,0.510884129221171,"GSE12790, GSE31625, Coldren et al",3,0,"",0.751654207965371 +"KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.373333333333333,1.42591491097237,0.112745529661901,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226 +"KEGG_MTOR_SIGNALING_PATHWAY",0.372333333333333,1.15660552191892,0.481878888268005,"GSE12790, GSE31625, Coldren et al",3,0,"",0.722818332402008 +"KEGG_FATTY_ACID_METABOLISM",0.366666666666667,1.29616099823029,0.2710663192045,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982 +"KEGG_VIBRIO_CHOLERAE_INFECTION",0.366666666666667,0.989966329393749,0.779979683108463,"GSE12790, GSE31625, Coldren et al",3,0,"",0.906726381613588 +"KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.356666666666667,1.47242430478899,0.088068034548536,"GSE12790, GSE31625, Coldren et al",3,0,"",0.327613088520554 +"KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.35,1.65429743395799,0.0203926455488642,"GSE12790, GSE31625, Coldren et al",3,0,"",0.164054772359422 +"KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.345333333333333,1.11151128349348,0.612530164941694,"GSE12790, GSE31625, Coldren et al",3,0,"",0.819644681145001 +"KEGG_RETINOL_METABOLISM",0.34,1.59361224894891,0.0466535439311036,"GSE12790, GSE31625, Coldren et al",3,0,"",0.241043310310702 +"KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.336,1.14222064418395,0.543307271439058,"GSE12790, GSE31625, Coldren et al",3,0,"",0.754142929012424 +"KEGG_MAPK_SIGNALING_PATHWAY",0.311333333333333,0.852192662097799,0.972035943988809,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999821414918504 +"KEGG_TYROSINE_METABOLISM",0.311,1.49392201938388,0.0757485972788716,"GSE12790, GSE31625, Coldren et al",3,0,"",0.293525814455628 +"KEGG_MELANOMA",0.305333333333333,1.04215178037239,0.705767002995794,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702 +"KEGG_GLUTATHIONE_METABOLISM",0.295,1.44997413770039,0.155055507277937,"GSE12790, GSE31625, Coldren et al",3,0,"",0.425664079560681 +"KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.286666666666667,1.73234907952564,0.0204254493988953,"GSE12790, GSE31625, Coldren et al",3,0,"",0.164054772359422 +"KEGG_LONG_TERM_DEPRESSION",0.283666666666667,0.948827873396083,0.89675507098725,"GSE12790, GSE31625, Coldren et al",3,0,"",0.965651312850048 +"KEGG_GLYCEROLIPID_METABOLISM",0.280333333333333,1.27712189446949,0.271694234906025,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982 +"KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.275666666666667,1.24632914325764,0.429123434671686,"GSE12790, GSE31625, Coldren et al",3,0,"",0.665141323741113 +"KEGG_INSULIN_SIGNALING_PATHWAY",0.269333333333333,0.826704501822346,0.968001466282383,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999821414918504 +"KEGG_OLFACTORY_TRANSDUCTION",0.263333333333333,1.00752882506325,0.841300115639517,"GSE12790, GSE31625, Coldren et al",3,0,"",0.937016895263175 +"KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.255666666666667,1.33555094748697,0.2430271129191,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982 +"KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.243,1.67320261773642,0.0331808169251463,"GSE12790, GSE31625, Coldren et al",3,0,"",0.212814894761283 +"KEGG_TASTE_TRANSDUCTION",0.241,0.867140703692313,0.978254231712166,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999821414918504 +"KEGG_CARDIAC_MUSCLE_CONTRACTION",0.237,0.935726455755099,0.946484877120205,"GSE12790, GSE31625, Coldren et al",3,0,"",0.994611226804283 +"KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.235333333333333,1.10668709820497,0.688506823112401,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702 +"KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.231,1.00154530601466,0.824460497620523,"GSE12790, GSE31625, Coldren et al",3,0,"",0.929391833681316 +"KEGG_HISTIDINE_METABOLISM",0.22,1.42042247236518,0.225992905097543,"GSE12790, GSE31625, Coldren et al",3,0,"",0.484651487429311 +"KEGG_ALZHEIMERS_DISEASE",0.215,0.853903390320006,0.984906791411828,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999836414226464 +"KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.210666666666667,1.65535534956496,0.0487379188084848,"GSE12790, GSE31625, Coldren et al",3,0,"",0.243435273663563 +"KEGG_LONG_TERM_POTENTIATION",0.208666666666667,0.81898371982191,0.995275635269174,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999836414226464 +"KEGG_HOMOLOGOUS_RECOMBINATION",0.204333333333333,0.71244391592134,0.999836414226464,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999836414226464 +"KEGG_ARGININE_AND_PROLINE_METABOLISM",0.141333333333333,1.14306444846007,0.640625546716018,"GSE12790, GSE31625, Coldren et al",3,0,"",0.845080508433897 +"KEGG_LINOLEIC_ACID_METABOLISM",0.13,1.66385095486345,0.049741598604489,"GSE12790, GSE31625, Coldren et al",3,0,"",0.243435273663563 +"KEGG_PROPANOATE_METABOLISM",0.123333333333333,1.56180451188148,0.113640230177712,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226 +"KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.098,1.43592896760251,0.22140864513936,"GSE12790, GSE31625, Coldren et al",3,0,"",0.484651487429311 +"KEGG_TRYPTOPHAN_METABOLISM",0.0906666666666666,1.26719585437032,0.469481660803075,"GSE12790, GSE31625, Coldren et al",3,0,"",0.709947877311967 +"KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.079,1.11892939902391,0.710534584888573,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702 +"KEGG_CELL_CYCLE",0.0143333333333333,1.10123128058248,0.701501369994042,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702 +"KEGG_NON_HOMOLOGOUS_END_JOINING",-0.00366666666666671,1.67707851138023,0.0591112515022086,"GSE12790, GSE31625, Coldren et al",3,0,"",0.25569052975374 +"KEGG_PYRUVATE_METABOLISM",-0.0499999999999999,1.6285883457768,0.0684660160213429,"GSE12790, GSE31625, Coldren et al",3,0,"",0.276840847390647 +"KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.053,1.80878605700066,0.0724248090134894,"GSE12790, GSE31625, Coldren et al",3,0,"",0.286617329287426 +"KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.068,1.20244293003868,0.535507316993309,"GSE12790, GSE31625, Coldren et al",3,0,"",0.754142929012424 +"KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.0896666666666667,1.32884548888625,0.274239874108206,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982 +"KEGG_PROTEASOME",-0.118,1.32494226289299,0.256824373349329,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982 +"KEGG_OTHER_GLYCAN_DEGRADATION",-0.138,1.66089493948293,0.0371314723757607,"GSE12790, GSE31625, Coldren et al",3,0,"",0.219324697141609 +"KEGG_PEROXISOME",-0.152333333333333,1.19721189992972,0.521308563588886,"GSE12790, GSE31625, Coldren et al",3,0,"",0.751654207965371 +"KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.154333333333333,1.23740710089014,0.364211432437172,"GSE12790, GSE31625, Coldren et al",3,0,"",0.589232362891106 +"KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.167333333333333,1.37186053712953,0.218406812226338,"GSE12790, GSE31625, Coldren et al",3,0,"",0.484651487429311 +"KEGG_BETA_ALANINE_METABOLISM",-0.206,1.10537821581575,0.672238625123212,"GSE12790, GSE31625, Coldren et al",3,0,"",0.874380309600821 +"KEGG_GAP_JUNCTION",-0.206666666666667,1.0753759032698,0.721149680345126,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702 +"KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.209666666666667,0.953415089734442,0.942412372032921,"GSE12790, GSE31625, Coldren et al",3,0,"",0.994611226804283 +"KEGG_LYSINE_DEGRADATION",-0.237666666666667,0.768586581546499,0.996110308194897,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999836414226464 +"KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.266,1.06526100088194,0.716291182346385,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702 +"KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.269,1.50847041734334,0.108118226467449,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226 +"KEGG_PYRIMIDINE_METABOLISM",-0.290666666666667,0.945952077715004,0.903351228150045,"GSE12790, GSE31625, Coldren et al",3,0,"",0.965651312850048 +"KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.313333333333333,1.52487157929228,0.0607960428239783,"GSE12790, GSE31625, Coldren et al",3,0,"",0.257001453755908 +"KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.315,1.03396373243939,0.776139368676975,"GSE12790, GSE31625, Coldren et al",3,0,"",0.906726381613588 +"KEGG_RIBOFLAVIN_METABOLISM",-0.336333333333333,1.00958919038059,0.762080665220213,"GSE12790, GSE31625, Coldren et al",3,0,"",0.906726381613588 +"KEGG_BASE_EXCISION_REPAIR",-0.376333333333333,1.10588983779278,0.590833687529622,"GSE12790, GSE31625, Coldren et al",3,0,"",0.808051955003747 +"KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.389666666666667,0.761196645639833,0.902964607159073,"GSE12790, GSE31625, Coldren et al",3,0,"",0.965651312850048 +"KEGG_SELENOAMINO_ACID_METABOLISM",-0.448666666666667,1.01692936496756,0.684418008860076,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702 +"KEGG_BUTANOATE_METABOLISM",-0.454,1.10271845908192,0.516133334098852,"GSE12790, GSE31625, Coldren et al",3,0,"",0.751654207965371 +"KEGG_OXIDATIVE_PHOSPHORYLATION",-0.459666666666667,1.00626553818231,0.649637077651426,"GSE12790, GSE31625, Coldren et al",3,0,"",0.850933073543417 +"KEGG_SPLICEOSOME",-0.481666666666667,0.82347697802266,0.821977542438924,"GSE12790, GSE31625, Coldren et al",3,0,"",0.929391833681316 +"KEGG_REGULATION_OF_AUTOPHAGY",-0.506,1.07450267565977,0.541511477158289,"GSE12790, GSE31625, Coldren et al",3,0,"",0.754142929012424 +"KEGG_PROTEIN_EXPORT",-0.55,1.17936423550996,0.25016629122266,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982 +"KEGG_SPHINGOLIPID_METABOLISM",-0.581333333333333,1.13404820591249,0.312640729071276,"GSE12790, GSE31625, Coldren et al",3,0,"",0.540936836241841 +"KEGG_ABC_TRANSPORTERS",-0.604,1.16105469294086,0.292885843648193,"GSE12790, GSE31625, Coldren et al",3,0,"",0.513931763382678 +"KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.625333333333333,1.31791704341864,0.133433956529378,"GSE12790, GSE31625, Coldren et al",3,0,"",0.393947871658163 +"KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.660666666666667,1.33032377011513,0.110285794990918,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226 +"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.67,2.25486141481023,5.37007940441247e-05,"GSE12790, GSE31625, Coldren et al",3,2,"GSE12790, Coldren et al",0.0049941738461036 +"KEGG_OOCYTE_MEIOSIS",-0.704333333333333,0.161295794530835,0.975179352858966,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999821414918504 +"KEGG_NITROGEN_METABOLISM",-0.721333333333333,1.43064507594768,0.0510428799617149,"GSE12790, GSE31625, Coldren et al",3,0,"",0.243435273663563 +"KEGG_HUNTINGTONS_DISEASE",-0.73,0.109822584198333,0.978319879113805,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999821414918504 +"KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.733333333333333,1.4773399518504,0.0299925730022647,"GSE12790, GSE31625, Coldren et al",3,1,"GSE31625",0.202195220019937 +"KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.74,1.83076486748026,0.0400916113054554,"GSE12790, GSE31625, Coldren et al",3,0,"",0.219324697141609 +"KEGG_MISMATCH_REPAIR",-0.825333333333333,0.289891933888015,0.767955796509243,"GSE12790, GSE31625, Coldren et al",3,0,"",0.906726381613588 +"KEGG_PARKINSONS_DISEASE",-0.833333333333333,0.171797361252533,0.84126064431873,"GSE12790, GSE31625, Coldren et al",3,0,"",0.937016895263175 +"KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.897333333333333,0.338919361107231,0.577509183595577,"GSE12790, GSE31625, Coldren et al",3,0,"",0.795679319620572 +"KEGG_DNA_REPLICATION",-0.907,0.584151521439429,0.322948050882043,"GSE12790, GSE31625, Coldren et al",3,0,"",0.551085664807889 +"KEGG_PURINE_METABOLISM",-0.972666666666667,0.306596368754317,0.500569404869013,"GSE12790, GSE31625, Coldren et al",3,0,"",0.744847274445091 +"KEGG_RIBOSOME",-1.094,0.560328475092958,0.183819169330655,"GSE12790, GSE31625, Coldren et al",3,0,"",0.46857829135485 +"KEGG_RNA_DEGRADATION",-1.11533333333333,0.222363066477626,0.245025708596824,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982 +"KEGG_ONE_CARBON_POOL_BY_FOLATE",-1.244,0.371144176836981,0.0526254256615666,"GSE12790, GSE31625, Coldren et al",3,0,"",0.244708229326285 +"KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-1.32933333333333,0.400526320400212,0.0641782944880848,"GSE12790, GSE31625, Coldren et al",3,1,"Coldren et al",0.265270283884084 +"KEGG_RNA_POLYMERASE",-1.38333333333333,0.150443787951957,0.0570888042612656,"GSE12790, GSE31625, Coldren et al",3,0,"",0.252821847442748 +"KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-1.57333333333333,0.383970484976819,0.00261115175162882,"GSE12790, GSE31625, Coldren et al",3,1,"Coldren et al",0.0809457043004935 +"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-1.61666666666667,0.334713808100791,0.00519644916365529,"GSE12790, GSE31625, Coldren et al",3,0,"",0.118081321295803 diff --git a/Examples/Fig2/GSEA/GSEA_results.csv b/Examples/Fig2/GSEA/GSEA_results.csv new file mode 100644 index 0000000..7c36aa8 --- /dev/null +++ b/Examples/Fig2/GSEA/GSEA_results.csv @@ -0,0 +1,559 @@ +"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"GSE12790","Log2FC","KEGG_ABC_TRANSPORTERS",-0.27215,-0.94,0.526,21386,0.864,"ABCG1, ABCD2, ABCA2, ABCA3, ABCC11",0.279014255846261,0.0634862575211067,FALSE +"GSE12790","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.29499,0.858,0.681,3717,0.783,"CCNA1, PIK3CD, KIT, TCF7L1, TCF7, STAT5A, AKT3, PML, PPARD, PIM1, PIK3CG, KRAS, NRAS, JUP",0.166852888087215,0.106238237942057,FALSE +"GSE12790","Log2FC","KEGG_ADHERENS_JUNCTION",0.47303,1.38,0.0822,2153,0.29,"SNAI2, RAC2, MET, NECTIN3, TGFBR2, EGFR, PTPRB, LMO7, TCF7L1, TCF7, CTNNA2, FYN, SMAD3, ACTN4",1.08512818245995,0.537602002101044,FALSE +"GSE12790","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.3243,0.943,0.529,6013,0.692,"IRS2, ACSL5, ACSL4, TNF, TNFRSF1B, NPY, AKT3, PRKAA1, PPARA, CAMKK1, SLC2A4, ADIPOQ, CD36, SLC2A1, PPARGC1A, STAT3, AGRP, NFKBIB, PRKAG2",0.276544327964814,0.159893905543242,FALSE +"GSE12790","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.38574,-1.34,0.13,18837,0.81,"GPT2, ACY3, ASL, GLS2, GLUL, ASS1, ABAT, CPS1, ALDH5A1, GAD1, ALDH4A1, GLUD2",0.886056647693163,0.0915149811213502,FALSE +"GSE12790","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.32434,0.956,0.495,3448,0.676,"SGK1, IRS2, PIK3CD, SFN, PRKCA, SCNN1A, PIK3CG, SCNN1G, ATP1B2, KRAS",0.305394801066431,0.170053304058364,FALSE +"GSE12790","Log2FC","KEGG_ALLOGRAFT_REJECTION",0.61996,1.8,0.0119,3798,0.226,"HLA-G, HLA-A, HLA-B, FAS, TNF, HLA-F, IL5, HLA-C, CD40, HLA-E, HLA-DOB, HLA-DPA1, CD86, HLA-DPB1, IL12A, HLA-DMA, CD28",1.92445303860747,0.645891560852599,TRUE +"GSE12790","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.46814,1.39,0.0948,2016,0.29,"PLA2G4A, PLA2G1B, PLA2G2F",1.02319166266193,0.537602002101044,FALSE +"GSE12790","Log2FC","KEGG_ALZHEIMERS_DISEASE",0.23914,0.706,0.887,1303,0.927,"CALML5, IL1B, LPL, COX6B2, APOE, GRIN2D, SNCA, COX7B2, FAS, TNF, BACE2",0.0520763801682736,0.0329202658555029,FALSE +"GSE12790","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.37994,-1.24,0.211,16095,0.735,"NARS2, DARS2, MARS2, IARS2, EARS2, MTFMT, HARS2, SEPSECS, PARS2, AARS2",0.675717544702307,0.133712660915805,FALSE +"GSE12790","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.24258,0.707,0.889,7514,0.933,"PGM1, GFPT2, CHIA, GMDS, PGM3, CMAS, GNE, HK3, UGP2, GNPDA2, PGM2, NPL",0.0510982390297863,0.0301183562535,FALSE +"GSE12790","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.45031,1.3,0.134,2885,0.361,"GPX1, CASP1, GRIN2D, TNF, MAPK13, TNFRSF1B, NEFH, CAT, MAP3K5, PRPH2",0.872895201635192,0.442492798094342,FALSE +"GSE12790","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.52407,1.52,0.0524,3772,0.244,"CTSS, HLA-G, HLA-A, HLA-B, TAP2, HLA-F, IFNA4, CTSB, TAP1, KIR3DL1, HLA-C, HSPA2, HLA-E, HLA-DOB, CD74, KIR2DL3, HLA-DPA1, KIR2DS3, TAPBP, HLA-DPB1, IFNA7, B2M, HLA-DMA, CALR, KIR2DL4, CD4",1.28066871301627,0.612610173661271,FALSE +"GSE12790","Log2FC","KEGG_APOPTOSIS",0.36811,1.08,0.331,6072,0.549,"IL1A, BIRC3, TNFSF10, IL1B, IRAK3, PIK3CD, IL1RAP, FAS, TNF, AKT3, IRAK2, MAP3K14, PIK3CG, IL3, TNFRSF10D, MYD88, CASP10, CAPN2, PRKACG, TNFRSF10B, PRKAR2B, CASP8, ENDOD1, BIRC2, CAPN1, IL3RA, PPP3CC, ATM, NGF, PRKACA, PRKAR1B, CHP2",0.480172006224281,0.260427655549908,FALSE +"GSE12790","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",0.5947,1.74,0.0164,1142,0.25,"PTGS2, PLA2G4A, AKR1C3, GPX1, CBR1, GPX3, GPX7, ALOX5, CYP4F3, PTGES, ALOX12, PTGIS, PLA2G1B",1.7851561519523,0.602059991327962,FALSE +"GSE12790","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.22721,0.667,0.917,4727,0.947,"MAOA, NAGS, GATM, ODC1, OTC, ALDH2, PRODH2, P4HA2, SAT1, CKB, GLS, OAT",0.0376306643299789,0.0236500209967266,FALSE +"GSE12790","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.54299,1.57,0.0342,3146,0.24,"CDH2, ITGA4, ITGB4, ITGA6, ITGA2, GJA1, RYR2, ITGB8, DMD, PKP2, ITGA3, ITGA5, DSC2, TCF7L1, TCF7, CTNNA2, DSP, SLC8A1, DSG2, ACTN4, ITGA1, ITGB1, CACNG7, CACNA2D1, ACTN1, CACNA1S",1.46597389394386,0.619788758288394,TRUE +"GSE12790","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.32599,-1.13,0.274,20210,0.799,"UGT2B17, ALDH9A1, UGT2B4, UGT2B28",0.562249437179612,0.0974532206860086,FALSE +"GSE12790","Log2FC","KEGG_ASTHMA",0.43694,1.27,0.155,3847,0.351,"TNF, IL5, CD40, HLA-DOB, HLA-DPA1, IL3, HLA-DPB1, HLA-DMA, PRG2",0.809668301829709,0.454692883534176,FALSE +"GSE12790","Log2FC","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.54382,1.58,0.0302,3798,0.238,"HLA-G, HLA-A, HLA-B, FAS, HLA-F, IL5, IFNA4, HLA-C, CD40, HLA-E, HLA-DOB, HLA-DPA1, CD86, HLA-DPB1, IFNA7, HLA-DMA, CD28",1.51999305704285,0.623423042943488,TRUE +"GSE12790","Log2FC","KEGG_AXON_GUIDANCE",0.42192,1.22,0.189,4305,0.391,"RAC2, MET, SEMA3A, ROBO3, EFNB2, EPHA2, NTN4, L1CAM, EPHB2, GNAI1, EPHA4, EPHA3, DPYSL2, PAK3, PAK6, NTN3, FYN, ABLIM3, SEMA7A, UNC5D, EPHB6, UNC5B, EFNB3, ITGB1, ABLIM1, SEMA3B, NRP1, UNC5C, FES, EFNB1, KRAS, SEMA4F, NRAS, EPHA1, NFAT5, PLXNA2, CFL2, PLXNC1, PLXNA1",0.723538195826756,0.407823242604133,FALSE +"GSE12790","Log2FC","KEGG_BASAL_CELL_CARCINOMA",0.49512,1.47,0.0595,2072,0.264,"WNT10A, BMP2, WNT16, WNT11, WNT7A, FZD10, SMO, TCF7L1, TCF7, FZD6, WNT5B, FZD2, GLI1, WNT9A",1.22548303427145,0.578396073130169,FALSE +"GSE12790","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.18577,-0.635,0.966,4116,1,"GTF2F2, TAF4B, STON1, GTF2B, GTF2H1, TBPL1, TAF2, TAF12, GTF2H4, GTF2H3, GTF2I, TAF11, TAF10, TAF7L, TAF5, TBP, TAF4, GTF2E2, GTF2F1, GTF2A1L, TAF13, TAF5L, TAF1, TAF6, GTF2IRD1, TAF7, GTF2A2, TAF9B, TAF1L, GTF2A1, TAF6L, GTF2E1",0.0150228735845067,0,FALSE +"GSE12790","Log2FC","KEGG_BASE_EXCISION_REPAIR",-0.27538,-0.958,0.462,15049,0.883,"POLB, PARP1, POLE2, POLD3, SMUG1, FEN1, PCNA, POLD2, MBD4, APEX2, POLE3, XRCC1, TDG, MPG",0.335358024443874,0.0540392964224314,FALSE +"GSE12790","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.23359,-0.817,0.715,18988,1,"UPB1, CNDP1, MLYCD, ALDH9A1, ABAT, GAD1",0.145693958198919,0,FALSE +"GSE12790","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.30988,-1.06,0.349,19657,0.944,"FADS2, BAAT, ACOX3, ACOT4, SCD",0.45717457304082,0.025028005701931,FALSE +"GSE12790","Log2FC","KEGG_BLADDER_CANCER",0.51899,1.51,0.0492,3707,0.224,"CXCL8, DAPK1, EGFR, VEGFC, CDKN2A, THBS1, MMP1, MMP2, TYMP, MMP9, KRAS, EGF, NRAS",1.30803489723264,0.649751981665837,TRUE +"GSE12790","Log2FC","KEGG_BUTANOATE_METABOLISM",-0.30894,-1.04,0.354,19867,0.895,"PDHB, PDHA2, HADH, ALDH9A1, ABAT, ACSM3, ALDH5A1, GAD1, BDH2",0.450996737974212,0.048176964684088,FALSE +"GSE12790","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.3178,0.928,0.558,1920,0.703,"RAC2, LYN, PIK3AP1, DAPP1, CARD11, PIK3CD, IFITM1, SYK, AKT3, RASGRP3",0.253365801062421,0.153044674980176,FALSE +"GSE12790","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.36112,1.05,0.381,3800,0.578,"CALML5, GNA15, RYR2, RYR1, ADRA1B, ADRB2, ADORA2B, EGFR, ADCY7, EDNRB, PTGFR, HRH1, P2RX5, GRIN2D, BST1, CAMK4, HTR7, OXTR, SLC8A1, LHCGR, P2RX3, PRKCA, CHRM5, TRPC1, AVPR1A, PTAFR, PTK2B, PLCZ1, GNAL, CHRM3, P2RX7, PLCE1, CACNA1S, HTR5A, TNNC2, PLCD1, ADCY3, PRKACG, PDGFRB",0.419075024324381,0.238072161579471,FALSE +"GSE12790","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.26005,0.749,0.822,3146,0.886,"RYR2, COX6B2, COX7B2, SLC9A6, TPM2, MYL2, SLC8A1, TPM4, CACNG7, CACNA2D1, ATP1B2, CACNA1S",0.0851281824599496,0.0525662781129492,FALSE +"GSE12790","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.4322,1.26,0.166,3090,0.356,"CDH3, CLDN1, CDH2, ITGA4, ITGA6, ICAM2, L1CAM, NECTIN3, ICAM1, CLDN11, CD274, PDCD1LG2, ITGB8, HLA-G, HLA-A, CLDN7, HLA-B, ITGB2, CLDN10, HLA-F, VCAN, CDH5, CLDN6, HLA-C, CD40, HLA-E, HLA-DOB, CNTN1, HLA-DPA1, ITGB1, ITGAM, NLGN1, CD86, HLA-DPB1",0.779891911959945,0.448550002027125,FALSE +"GSE12790","Log2FC","KEGG_CELL_CYCLE",0.26042,0.764,0.82,3994,0.87,"CCNA1, CDK6, GADD45A, CDKN2A, TGFB2, SFN, CDKN2B, SMC1B, SMAD3, CDC14B, CCNB3, TGFB1, TTK, SKP2, SMC3, TFDP1, CDKN1C, CDC16, ORC3",0.0861861476162833,0.0604807473813815,FALSE +"GSE12790","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.36207,1.05,0.352,3764,0.578,"CXCL1, RAC2, CXCL8, CXCL11, CXCL6, CXCL5, LYN, CCL5, CXCL16, CCL20, GNAI1, ADCY7, CXCL3, GNB4, ELMO1, PIK3CD, CCR3, NCF1, GNG11, CXCL2, PPBP, AKT3, CCL8, GNGT1, ARRB2, CXCL10, XCL1, PXN, GNG12, PIK3CG, PTK2B, FOXO3, GNG4, DOCK2, CCL18, KRAS, TIAM2, VAV1, STAT1, CCR9, NRAS, ADCY3, PRKACG",0.453457336521869,0.238072161579471,FALSE +"GSE12790","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.29517,0.858,0.66,4055,0.783,"TGFBR2, CDK6, PIK3CD, CDKN2A, TGFB2, CBLC, STAT5A, AKT3, SMAD3, GAB2, PIK3CG, TGFB1, KRAS, CBLB, NRAS, TGFBR1",0.180456064458131,0.106238237942057,FALSE +"GSE12790","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.54755,1.61,0.0358,1307,0.256,"BHLHE41, NPAS2",1.44611697335613,0.59176003468815,FALSE +"GSE12790","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.48203,-1.62,0.0422,14986,1,"ACO1, ACO2, CS, SDHB, PDHA1, MDH2, FH, SUCLG1, PCK2, IDH3B, PCK1, ACLY, IDH3G, IDH2, PDHB, PDHA2, SDHC, PC, OGDHL",1.37468754903833,0,FALSE +"GSE12790","Log2FC","KEGG_COLORECTAL_CANCER",0.30999,0.903,0.594,2664,0.734,"RAC2, TGFBR2, PIK3CD, TGFB2, TCF7L1, TCF7, AKT3, SMAD3, PIK3CG, TGFB1",0.226213555018806,0.134303940083929,FALSE +"GSE12790","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.54377,1.59,0.0288,4714,0.268,"C3, PLAU, F3, PLAT, SERPINE1, CFH, C1S, PROC, PLAUR, SERPING1, C1QA, C1R, SERPINF2, CD59, F9, CFI, C9, MBL2, C6, CPB2, F13B, FGG, CFB, C7, C3AR1, TFPI",1.54060751224077,0.571865205971211,FALSE +"GSE12790","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.47997,1.4,0.0774,4584,0.283,"LDHB, IL4I1, MTAP, CTH, CBS, LDHAL6B, CDO1, DNMT1, MAT2B",1.11125903931711,0.54821356447571,FALSE +"GSE12790","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.53509,1.56,0.0256,4061,0.231,"INHBA, CXCL1, TNFRSF11B, CXCL8, IL1R2, CXCL11, MET, TSLP, TNFRSF21, IL6, IL18, CXCL6, IL7R, IL1A, CXCL5, BMP2, CCL5, LIF, TNFSF10, IL1B, TGFBR2, CXCL16, CCL20, EGFR, VEGFC, IL15, IL20RA, IL11, IL4R, IL15RA, IL7, CXCL3, CSF2, KDR, OSMR, KIT, IL20RB, IL1RAP, FAS, CCR3, TNF, INHBE, TGFB2, IFNLR1, TNFRSF1B, IL5, IFNA4, CSF2RA, CXCL2, CTF1, PPBP, IL22RA1, CCL8, CXCL10, XCL1, IL24, CD70, TNFRSF25, CD40, TNFRSF14, IFNK, TNFRSF17, IL21, CLCF1, TNFSF15, IL2RG, CSF1R, TGFB1, IFNGR1, IL3, TNFSF11, IL12RB1, IL18R1, IL12A, LTB, IFNE, IFNA7, TNFRSF10D, TNFSF4, CCL18, EGF, TNFRSF8, RELT, CCR9, PDGFRB, TNFSF13B, IL23A, PDGFC, TGFBR1, CCL22, IFNGR2",1.59176003468815,0.636388020107856,TRUE +"GSE12790","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.52134,1.51,0.0635,2491,0.224,"IL6, IL18, AIM2, CCL5, CASP1, IL1B, PYCARD, IFNA4, CXCL10, DDX58",1.19722627470802,0.649751981665837,FALSE +"GSE12790","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",0.4373,1.25,0.169,4450,0.365,"ITGA4, ITGB4, ITGA6, ITGA2, RYR2, ADCY7, ITGB8, DMD, ITGA3, ITGA5, TNF, TPM2, TGFB2, MYL2, SLC8A1, ITGA1, TGFB1, ITGB1, TPM4, CACNG7, CACNA2D1, CACNA1S, SGCB, ADCY3, PRKACG, PLN, MYBPC3, MYH7, ADCY8, LAMA2",0.772113295386326,0.437707135543525,FALSE +"GSE12790","Log2FC","KEGG_DNA_REPLICATION",-0.20164,-0.683,0.919,4467,1,"PRIM2, RNASEH2B, RNASEH1, RPA1, POLD1, RFC4, RFC3, RFC1, POLD4, RPA4, MCM3, DNA2, PRIM1, RNASEH2A, RPA3, POLE, LIG1, SSBP1, MCM5, POLE4, MCM7, MCM2, RFC5, POLE2, POLD3, RNASEH2C, RPA2, MCM4, FEN1, PCNA, POLD2, POLA1, POLE3, POLA2, RFC2, MCM6",0.0366844886138887,0,FALSE +"GSE12790","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.53944,1.58,0.0367,4875,0.238,"ETS1, EGFR, ETS2, NOTCH3, ETV7, PIWIL4, KRAS, ETV6, SPIRE1, SOS1, NOTCH4",1.43533393574791,0.623423042943488,TRUE +"GSE12790","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.39249,1.14,0.263,5142,0.498,"GSTP1, ALDH1A3, ALDH3A1, MAOA, MGST1, ALDH3B1, UGT1A6, ADH1C, FMO3, GSTO1, ADH1B, ADH7, CYP3A4, CYP2E1, CYP2A7, ADH4, CYP3A5, MGST2, CYP2B6, CYP2D6, CYP2C8",0.580044251510242,0.302770657240282,FALSE +"GSE12790","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.39861,1.17,0.228,2219,0.46,"CDA, UPP1, XDH, DPYD, UGT1A6, TYMP",0.642065152999546,0.337242168318426,FALSE +"GSE12790","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.6294,1.84,0.00942,2866,0.208,"LAMC2, LAMB3, COL6A2, COL4A1, ITGA4, CD44, ITGB4, ITGA6, COL5A2, COL6A3, ITGA2, HSPG2, COL4A2, SV2A, COL6A1, LAMA4, COL4A6, LAMB1, ITGB8, COL1A2, ITGA3, LAMA3, ITGA5, FN1, THBS1, LAMC1, COMP, THBS2, ITGA1, TNXB, ITGB1, TNC",2.02594909720712,0.681936665037238,TRUE +"GSE12790","Log2FC","KEGG_ENDOCYTOSIS",0.26906,0.765,0.8,2564,0.875,"MET, ADRB2, EHD2, EGFR, RAB31, ARAP3, SH3KBP1, DNM1, HLA-G, KDR, HLA-A, KIT, PLD1, HLA-B, HLA-F, CBLC, ARRB2, HLA-C, HSPA2, HLA-E, ASAP1, IL2RG, CSF1R, CHMP1B",0.0969100130080564,0.0579919469776868,FALSE +"GSE12790","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.28432,0.835,0.705,5328,0.813,"EGFR, PIK3CD, TCF7L1, TCF7, CTNNA2, AKT3, PIK3CG, FOXO3, KRAS, EGF, NRAS, MLH1, SOS1, CTNNA3, MYC, CDH1, CTNNB1",0.151810883008601,0.0899094544059319,FALSE +"GSE12790","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.46544,1.35,0.115,1897,0.312,"CXCL1, CXCL8, MET, LYN, CCL5, PTPRZ1, EGFR, MAPK13, HBEGF, TCIRG1, MAP3K14",0.939302159646388,0.505845405981557,FALSE +"GSE12790","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.33451,0.967,0.493,3707,0.667,"EREG, TGFA, EGFR, PIK3CD, NRG4, PAK3, PAK6, HBEGF, CBLC, STAT5A, AKT3, PRKCA, NRG1, AREG, PIK3CG, KRAS, EGF, CBLB, NRAS",0.30715308072277,0.175874166083451,FALSE +"GSE12790","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.44868,1.29,0.128,2016,0.345,"PLA2G4A, AGPS, PLA2G7, PLD1, PLA2G1B, LPCAT2, PLA2G2F",0.892790030352132,0.462180904926726,FALSE +"GSE12790","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.38434,1.12,0.293,7056,0.511,"ACSL5, ACSL4, EHHADH, ACADVL, ADH1C, ALDH2, ADH1B, ACADL, ADH7, CYP4A11, ACADS, ADH4, ACAT2, ECI2, ALDH3A2, GCDH, ACAT1, ALDH1B1, ACADM, HADHB",0.533132379645891,0.291579099865287,FALSE +"GSE12790","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.39577,1.15,0.257,3707,0.484,"PLA2G4A, RAC2, LYN, CSF2, PIK3CD, PLA2G1B, TNF, MAPK13, IL5, FYN, SYK, AKT3, PLA2G2F, PRKCA, GAB2, PIK3CG, IL3, KRAS, VAV1, NRAS",0.590066876668705,0.315154638355588,FALSE +"GSE12790","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.35861,1.04,0.375,4326,0.592,"PLA2G4A, RAC2, LYN, MYO10, DNM1, MARCKS, PIK3CD, PLD1, NCF1, SYK, AKT3, PRKCA, GAB2, ASAP1, PIK3CG, ARPC1B, PLA2G4D, DOCK2, FCGR1A, VAV1, DNM3, CFL2, PLPP2, WASF2",0.425968732272281,0.22767829327708,FALSE +"GSE12790","Log2FC","KEGG_FOCAL_ADHESION",0.52221,1.52,0.0496,2589,0.244,"LAMC2, CAV1, LAMB3, CAV2, RAC2, COL6A2, COL4A1, MET, ITGA4, ITGB4, ITGA6, COL5A2, COL6A3, ITGA2, BIRC3, COL4A2, COL6A1, LAMA4, EGFR, VEGFC, COL4A6, LAMB1, ITGB8, COL1A2, ITGA3, KDR, PIK3CD, MYL9, LAMA3, PARVB, ITGA5, PAK3, PAK6, FN1, THBS1, FLNC, MYL2, FYN, AKT3, LAMC1, PXN, PRKCA, RASGRF1, ACTN4, COMP, THBS2, ITGA1, MYLPF, PIK3CG, TNXB",1.3045183235098,0.612610173661271,TRUE +"GSE12790","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.58041,1.73,0.0106,10,0.234,"ALPP",1.97469413473523,0.630784142589857,TRUE +"GSE12790","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.40475,1.18,0.218,2988,0.448,"AKR1B1, AKR1B10, GMDS, MTMR2, ALDOC",0.661543506395395,0.348721986001856,FALSE +"GSE12790","Log2FC","KEGG_GALACTOSE_METABOLISM",0.44744,1.29,0.132,1356,0.345,"AKR1B1, MGAM, PGM1",0.87942606879415,0.462180904926726,FALSE +"GSE12790","Log2FC","KEGG_GAP_JUNCTION",0.34726,1.01,0.434,4660,0.622,"TUBB6, GJA1, EGFR, GNAI1, ADCY7, LPAR1, TUBA4A, TUBB2B, PRKCA, TUBA8, KRAS, EGF, TUBB2A, MAPK7, NRAS, ADCY3, PRKACG, PDGFRB, PDGFC, TUBB4A, ADCY8, TUBB1, ITPR3, SOS1, HTR2C",0.362510270487489,0.206209615309181,FALSE +"GSE12790","Log2FC","KEGG_GLIOMA",0.32463,0.94,0.553,3800,0.685,"CALML5, TGFA, CDK6, EGFR, PIK3CD, CDKN2A, AKT3, PRKCA, PIK3CG, KRAS, EGF, NRAS, PDGFRB",0.257274868695302,0.164309428507574,FALSE +"GSE12790","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.43695,1.28,0.152,3581,0.348,"GSTP1, GPX1, GPX3, GPX7, MGST1, ODC1, ANPEP, GSTO1, OPLAH, GPX2, GCLM",0.818156412055227,0.458420756053419,FALSE +"GSE12790","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.4909,1.42,0.0801,4280,0.285,"AKR1B1, LIPG, GPAT3, LPL, AGPAT4, DGKG, LIPF, CEL, GK2, ALDH2, DGKA, MBOAT2, DGAT1, LIPC, PLPP2",1.09636748391576,0.54515513999149,FALSE +"GSE12790","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.32024,0.918,0.563,4321,0.717,"PLA2G4A, GPAT3, AGPAT4, DGKG, PLD1, PLA2G1B, LPCAT2, PLA2G2F, PCYT1B, PEMT, DGKA, MBOAT2, ADPRM, PLPP2, LPCAT4",0.249491605148654,0.1444808443322,FALSE +"GSE12790","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.36899,1.08,0.325,4472,0.549,"PSAT1, MAOA, GATM, CTH, CBS, DMGDH, PSPH, SRR, SHMT1",0.488116639021126,0.260427655549908,FALSE +"GSE12790","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.41046,1.22,0.172,3236,0.391,"LDHB, ALDH1A3, ALDH3A1, GALM, ENO2, PGM1, ALDH3B1, ADH1C, LDHAL6B, ALDH2, ALDOC, ADH1B, BPGM",0.764471553092451,0.407823242604133,FALSE +"GSE12790","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.50716,1.46,0.0595,2026,0.269,"CHST11, CHST3, CSGALNACT1, CHSY3, DSE",1.22548303427145,0.570247719997592,FALSE +"GSE12790","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.33931,1,0.409,1611,0.637,"HS6ST2, NDST3, EXT1, HS3ST1",0.388276691992658,0.19586056766465,FALSE +"GSE12790","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.49142,1.44,0.0697,8295,0.272,"B3GNT7, B4GALT4, FUT8, CHST4, CHST6, B3GNT2, B4GALT1, B4GALT2, CHST2",1.15676722190199,0.565431095965801,FALSE +"GSE12790","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.43467,1.27,0.15,795,0.351,"HYAL4, HPSE",0.823908740944319,0.454692883534176,FALSE +"GSE12790","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.29865,0.873,0.652,2339,0.775,"ST8SIA1, ST6GALNAC5",0.18575240426808,0.11069829749369,FALSE +"GSE12790","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.52019,1.51,0.05,2667,0.224,"GBGT1, ST8SIA1, FUT2",1.30102999566398,0.649751981665837,FALSE +"GSE12790","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.68553,2,0.00242,2932,0.113,"GCNT2, B3GNT5, B3GNT3, FUT3, ST8SIA1, B3GALT2, FUT4, ST3GAL6, FUT7, FUT2, B4GALT4",2.61618463401957,0.94692155651658,TRUE +"GSE12790","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.38134,-1.33,0.131,17084,0.733,"PIGU, PIGK, PIGC, DPM2, PIGW, PIGO, PIGH, PIGM, PIGN",0.882728704344236,0.134896025358872,FALSE +"GSE12790","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.28107,-0.968,0.477,14986,0.934,"ACO1, ACO2, CS, MDH2, MTHFD1L, MTHFD1, GRHPR, PGP",0.321481620959886,0.0296531237699066,FALSE +"GSE12790","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.34603,0.996,0.464,4534,0.639,"CALML5, PLA2G4A, MMP14, EGFR, ADCY7, PLD1, PLA2G1B, MAPK13, HBEGF, MMP2, PLA2G2F, PRKCA, PTK2B, CACNA1S, KRAS, MAPK7, NRAS, MAP3K4, ADCY3, PRKACG, GNRH1, GNRHR, ADCY8, MAP2K7, ITPR3, SOS1",0.333482019445119,0.1944991418416,FALSE +"GSE12790","Log2FC","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.68865,2.01,0,3798,0.311,"IL6, IL1A, IL1B, HLA-G, HLA-A, HLA-B, FAS, TNF, HLA-F, KIR3DL1, HLA-C, HLA-E, HLA-DOB, KIR2DL3, HLA-DPA1, CD86, HLA-DPB1, HLA-DMA, CD28",Inf,0.507239610973163,FALSE +"GSE12790","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.36655,1.05,0.373,2072,0.578,"WNT10A, BMP2, WNT16, WNT11, WNT7A, SMO, WNT5B, GLI1, WNT9A",0.428291168191312,0.238072161579471,FALSE +"GSE12790","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.59027,1.72,0.00948,3420,0.222,"IL1R2, IL6, ITGA4, IL7R, IL1A, CD44, ITGA6, ITGA2, IL1B, IL11, IL4R, IL7, CSF2, CD37, ITGA3, KIT, ITGA5, TNF, IL5, CSF2RA, CD3E, CD59, ITGA1, CD1D, CSF1R, ANPEP, ITGAM, IL3, CD1C, CD14, FCGR1A",2.02319166266193,0.653647025549361,TRUE +"GSE12790","Log2FC","KEGG_HISTIDINE_METABOLISM",0.36482,1.06,0.351,2923,0.577,"ALDH1A3, ALDH3A1, MAOA, ALDH3B1, ALDH2, TRMT11",0.454692883534176,0.238824186844269,FALSE +"GSE12790","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",-0.18202,-0.615,0.981,6140,1,"RPA1, TOP3A, RAD51, RAD52, POLD1, XRCC2, BLM, POLD4, RPA4, RAD51D, RPA3, SSBP1, MUS81, XRCC3, RAD51B, EME1, POLD3, RPA2, RAD54L, POLD2, NBN, TOP3B, RAD54B, RAD50, RAD51C",0.0083309926200515,0,FALSE +"GSE12790","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.22928,-0.769,0.779,18203,1,"NDUFA6, POLR2L, COX5B, NDUFB3, COX8A, PPID, ITPR1, NDUFC1, HTT, NDUFB2, NDUFA8, NDUFV3, POLR2G, TP53, NDUFB1, DCTN4, UQCR10, COX4I1, AP2S1, SIN3A, NDUFB10, NDUFS2, NDUFS3, COX8C, COX6B1, SLC25A6, NDUFAB1, SLC25A31, POLR2I, SDHC, NDUFA1, UQCRB, NDUFA3, CLTCL1, PLCB1, CREB3L4, COX7B, PLCB4, DNALI1",0.108462542327436,0,FALSE +"GSE12790","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.49279,1.44,0.0822,4155,0.272,"IL6, ITGA4, ITGB4, ITGA6, ITGA2, RYR2, ITGB8, DMD, ITGA3, ITGA5, TNF, TPM2, TGFB2, MYL2, SLC8A1, PRKAA1, ITGA1, TGFB1, ITGB1, TPM4, CACNG7, CACNA2D1, CACNA1S, SGCB, ACE, MYBPC3, MYH7",1.08512818245995,0.565431095965801,FALSE +"GSE12790","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.29586,-1.04,0.362,18853,0.895,"PIP5K1C, PIP4K2C, PI4KB, PLCD4, PLCG1, IPPK, IPMK, INPPL1, PIK3C2B, ALDH6A1, PIP4K2A, CDIPT, PI4KA, PLCB1, INPP5J, PLCB4",0.441291429466834,0.048176964684088,FALSE +"GSE12790","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.17801,0.51,0.998,6013,0.995,"CALML5, IRS2, PYGL, GYS2, PIK3CD, FOXO1, CBLC, AKT3, PRKAA1, PIK3CG, KRAS, PRKCI, CBLB, NRAS, PRKACG, SLC2A4, MKNK1, SOS1, PRKAR2B, CALML3, SOCS2, PPARGC1A, INSR, TRIP10, SORBS1, SOCS1, SHC3, PRKACA, CBL, PRKCZ, PRKAR1B, PRKAG2",0.000869458712628891,0.00217691925427455,FALSE +"GSE12790","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.47361,1.38,0.0898,6391,0.29,"IL6, ITGA4, IL15, IL15RA, IL5, MAP3K14, CD40, HLA-DOB, TNFRSF17, HLA-DPA1, TGFB1, CD86, HLA-DPB1, HLA-DMA, CCR9, CD28, TNFSF13B, CCL25, IL2, LTBR, CCL27, TNFSF13, IL4, TNFRSF13C, MADCAM1, CD80, AICDA",1.0467236633327,0.537602002101044,FALSE +"GSE12790","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.38763,1.12,0.267,6171,0.511,"TSLP, IL6, IL7R, LIF, IL15, IL20RA, IL11, IL4R, IL15RA, IL7, CSF2, OSMR, SPRY2, PIK3CD, IL20RB, IL13RA2, IFNLR1, IL5, CBLC, IFNA4, CSF2RA, CTF1, IL22RA1, STAT5A, AKT3, IL24, IFNK, IL21, CLCF1, IL2RG, PIM1, PIK3CG, IFNGR1, IL3, IL12RB1, IL12A, IFNE, IFNA7, STAT1, CBLB, IL23A, IFNGR2, STAT6, SPRY3, SOS1, IL2, CCND2, MYC, SOCS2, IL3RA, STAT3, IL4, SOCS1, IL10RB, IFNL2, TYK2, CBL, EPO, PRL, STAT5B, GH2, CNTF, SOCS5, IL9, IL12RB2",0.573488738635425,0.291579099865287,FALSE +"GSE12790","Log2FC","KEGG_LEISHMANIA_INFECTION",0.59547,1.7,0.0212,3656,0.227,"PTGS2, C3, NCF2, ITGA4, IL1A, IL1B, TLR2, ITGB2, TNF, TGFB2, MAPK13, NCF1, HLA-DOB, HLA-DPA1, TGFB1, IFNGR1, ITGB1, ITGAM, CYBA, HLA-DPB1, IL12A, MYD88, FCGR1A, HLA-DMA, STAT1",1.67366413907125,0.643974142806877,TRUE +"GSE12790","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.4872,1.41,0.0867,3079,0.283,"NCF2, RAC2, CLDN1, ITGA4, MSN, GNAI1, ICAM1, CLDN11, PIK3CD, CLDN7, MYL9, ITGB2, CLDN10, MAPK13, CTNNA2, MYL2, NCF1, CDH5, CLDN6, EZR, MMP2, RASSF5, PXN, PRKCA, THY1, ACTN4, MMP9, RAPGEF4, MYLPF, PIK3CG, TXK, PTK2B, ITGB1, ITGAM, CYBA, ACTN1",1.06198090252379,0.54821356447571,FALSE +"GSE12790","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.46665,1.35,0.102,3050,0.312,"EHHADH, ALDH2, YOD1",0.991399828238082,0.505845405981557,FALSE +"GSE12790","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",0.35684,1.03,0.385,2016,0.606,"PLA2G4A, PLA2G1B, AKR1B10, PLA2G2F",0.414539270491499,0.217527375833714,FALSE +"GSE12790","Log2FC","KEGG_LONG_TERM_DEPRESSION",0.32644,0.948,0.526,2099,0.688,"PLA2G4A, LYN, RYR1, GNAI1, PLA2G1B, PLA2G2F, PRKCA",0.279014255846261,0.162411561764489,FALSE +"GSE12790","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.23108,0.677,0.917,6072,0.945,"CALML5, GRIN2D, CAMK4, PRKCA, KRAS, NRAS, PRKACG, GRIA2, ADCY8, RPS6KA1, ITPR3, CALML3, GRIN2B, PPP3CC, GRM5, PRKACA, PLCB3, CHP2",0.0376306643299789,0.0245681914907371,FALSE +"GSE12790","Log2FC","KEGG_LYSINE_DEGRADATION",-0.17683,-0.599,0.978,18742,1,"NSD1, EHMT1, SETD1B, BBOX1, HADH, ALDH9A1, SETD7, OGDHL",0.00966114521239857,0,FALSE +"GSE12790","Log2FC","KEGG_LYSOSOME",0.23973,0.697,0.881,1603,0.931,"LAMP3, CTSV, ACP5, CTSS, LAPTM5, CTSH, AP1S3, TCIRG1, LIPA, CTSB",0.0550240915879521,0.0310503190186574,FALSE +"GSE12790","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",0.28678,0.835,0.696,4562,0.813,"PLA2G4A, RAC2, IL1R2, PTPRR, IL1A, IL1B, TGFBR2, EGFR, DUSP10, RRAS2, GADD45A, FAS, PLA2G1B, TNF, FGF11, TGFB2, RELB, MAPK13, FLNC, AKT3, MEF2C, ARRB2, MAP4K4, MAP3K14, RASGRP3, PLA2G2F, PRKCA, HSPA2, RASGRF1, NF1, GNG12, DUSP7, MAP3K5, FGF21, BDNF, DUSP6, TGFB1, RRAS, CACNG7, CACNA2D1, FGF2, RASA2, CACNA1S, CD14, KRAS, EGF, NFKB2, MAPK7, NRAS, MAP3K4, PRKACG, PDGFRB, MKNK1, TGFBR1, MAP3K8, NTRK2, FGF20, NTF3, RPS6KA1, FGF3, MAP2K7, SOS1, DUSP9",0.157390760389438,0.0899094544059319,FALSE +"GSE12790","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.52661,1.52,0.0517,4382,0.244,"PAX6, HHEX, NKX2-2, SLC2A2, FOXA3, BHLHA15, NR5A2, HNF4G, NEUROG3, PDX1",1.28650945690606,0.612610173661271,FALSE +"GSE12790","Log2FC","KEGG_MELANOGENESIS",0.39019,1.15,0.262,4327,0.484,"CALML5, WNT10A, GNAI1, WNT16, ADCY7, EDNRB, WNT11, KIT, WNT7A, FZD10, TCF7L1, TCF7, FZD6, WNT5B, FZD2, WNT9A, PRKCA, MITF, MC1R, KRAS, NRAS, ADCY3, PRKACG, FZD7, WNT7B, ADCY8, WNT2B, WNT6",0.581698708680255,0.315154638355588,FALSE +"GSE12790","Log2FC","KEGG_MELANOMA",0.26559,0.775,0.803,4422,0.881,"MET, CDK6, EGFR, PIK3CD, CDKN2A, FGF11, AKT3, FGF21, PIK3CG, MITF, FGF2, KRAS, EGF, NRAS, PDGFRB, PDGFC, FGF20, FGF3",0.095284454721319,0.0550240915879521,FALSE +"GSE12790","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.43549,1.28,0.143,5142,0.348,"GSTP1, AKR1C3, ALDH1A3, ALDH3A1, AKR1C4, MGST1, ALDH3B1, UGT1A6, ADH1C, CYP2S1, GSTO1, AKR1C1, ADH1B, CYP1B1, ADH7, CYP3A4, CYP2E1, DHDH, ADH4, CYP3A5, MGST2, CYP2B6, CYP2C8",0.844663962534938,0.458420756053419,FALSE +"GSE12790","Log2FC","KEGG_MISMATCH_REPAIR",-0.18866,-0.652,0.961,4182,1,"MLH1, MSH2, RPA1, MSH6, POLD1, RFC4, RFC3, RFC1, POLD4, RPA4, RPA3, MSH3, LIG1, SSBP1, EXO1, RFC5, POLD3, RPA2, MLH3, PCNA, POLD2, RFC2",0.0172766123314547,0,FALSE +"GSE12790","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",-0.27974,-0.963,0.466,19079,0.907,"EIF4EBP1, RPS6KB1, TSC1, RPS6KA6, MLST8, TSC2, AKT1, ULK3, ULK1, MAPK3, CAB39L, PIK3R1, PIK3R3",0.33161408331,0.0423927129399047,FALSE +"GSE12790","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.44783,1.29,0.16,4534,0.345,"RAC2, LCK, ICAM2, TNFSF10, ICAM1, HLA-G, CSF2, PIK3CD, HLA-A, HLA-B, ITGB2, FAS, TNF, MICB, FYN, IFNA4, SYK, KIR3DL1, HLA-C, PRKCA, HLA-E, PIK3CG, KIR2DL3, KIR2DS3, PTK2B, IFNGR1, IFNA7, TNFRSF10D, KRAS, VAV1, KIR2DL4, SH2D1B, NRAS, ULBP2, NFAT5, IFNGR2, LCP2, TNFRSF10B, SOS1",0.795880017344075,0.462180904926726,FALSE +"GSE12790","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.33595,0.974,0.475,5611,0.665,"GABRP, HTR1D, PTH2R, PRSS3, TAAR8, ADRA1B, ADRB2, ADORA2B, PRSS2, GLP2R, EDNRB, PTGFR, HRH1, CHRNB1, P2RX5, NR3C1, GRIN2D, LPAR3, LPAR1, P2RY1, S1PR1, GABRA3, FPR1, HTR7, GRM3, OXTR, PTGER4, PTGER2, GLRA1, GALR2, LHCGR, TAAR1, P2RX3, P2RY6, CHRM5, CHRM4, AVPR1A, S1PR5, PTAFR, CHRM3, CHRNA5, GRIN3A, P2RX7, MTNR1B, P2RY14, MC1R, GABRQ, HTR5A, GPR156, CNR1, HTR1E, FPR2, CHRNA9, F2RL1, GRIA2, FPR3, GRIK5, GRM2, TSPO, P2RY8, GNRHR, OPRD1, MAS1, NPFFR2, ADRA1D, GABRG1, C3AR1, HTR2C, GABRB1, GABRA4, CCKAR, GHRHR, GABRG2, CALCRL, GRIN2B, TBXA2R, TACR3, ADCYAP1R1, GALR3, GRM5, TSHB, TAAR5, NTSR2, MC4R, GLRB",0.323306390375133,0.177178354696895,FALSE +"GSE12790","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.22721,0.662,0.928,4534,0.938,"CALML5, IRS2, ARHGDIB, IRAK3, PIK3CD, CAMK4, MAPK13, SH2B3, AKT3, IRAK2, MAP3K5, BDNF, PIK3CG, FOXO3, KRAS, MAPK7, NRAS, NTRK2, NTF3, RPS6KA1, MAP2K7, SOS1",0.0324520237811379,0.0277971616209356,FALSE +"GSE12790","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.37466,1.08,0.335,926,0.549,"NT5E, NMNAT2, BST1",0.474955192963155,0.260427655549908,FALSE +"GSE12790","Log2FC","KEGG_NITROGEN_METABOLISM",-0.37926,-1.35,0.126,19632,0.915,"GLS2, GLUL, CPS1, GLUD2, CA8, CA5B, CA12",0.899629454882437,0.0385789059335517,FALSE +"GSE12790","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.68398,2,0.00121,1786,0.113,"CXCL1, CARD6, TNFAIP3, CXCL8, IL6, IL18, CCL5, BIRC3, CASP1, IL1B, NLRP1, PYCARD, NLRP3, TNF, MAPK13, CXCL2, CCL8, CASP5",2.91721462968355,0.94692155651658,TRUE +"GSE12790","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",0.32493,0.941,0.545,7933,0.689,"POLL, DNTT, POLM, DCLRE1C, LIG4, XRCC6, PRKDC",0.263603497723358,0.161780778092374,FALSE +"GSE12790","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.33567,0.973,0.487,3707,0.661,"TGFA, CDK6, EGFR, PIK3CD, CDKN2A, RASSF5, AKT3, PRKCA, PIK3CG, FOXO3, KRAS, EGF, NRAS",0.312471038785366,0.17979854051436,FALSE +"GSE12790","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.27442,0.806,0.762,2612,0.845,"MAML2, HES5, JAG1, NOTCH3, DTX3L, DTX4",0.1180450286604,0.0731432910503077,FALSE +"GSE12790","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.16843,-0.605,0.982,5460,1,"CUL4B, DDB2, RAD23A, GTF2H1, ERCC5, RPA1, GTF2H5, POLD1, ERCC6, GTF2H4, CDK7, RFC4, RFC3, GTF2H3, RFC1, POLD4, RPA4, XPA, RPA3, RAD23B, ERCC3, POLE, LIG1, ERCC1, POLE4, RBX1, RFC5, XPC, POLE2, POLD3, RPA2, ERCC2, MNAT1, PCNA, POLD2, CETN2, POLE3, ERCC4, ERCC8, DDB1, RFC2, CCNH",0.00788851221305034,0,FALSE +"GSE12790","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.29674,-0.997,0.417,17629,0.936,"MGAT2, MAN1B1, DOLPP1, DAD1, DPM2, MGAT3, MGAT4A, MAN2A2, ALG1, DPM3, MAN1C1",0.379863945026242,0.0287241512618947,FALSE +"GSE12790","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",0.3346,0.966,0.502,6189,0.663,"CALML5, OR5K1, CLCA4, OR2B3, OR1D5, OR10H3, ARRB2, OR5J2, OR3A2, OR5P3, OR1J2, CLCA1, GUCY2D, GNAL, OR5I1, OR2L13, OR5P2, OR10H1, OR51B5, ADCY3, PRKACG, OR2M4, OR51B2, OR11A1, OR3A3, OR1F1, OR2B2, OR8B8, OR13C4, GUCA1B, OR51I1, OR7C1, CALML3, OR1Q1, PDE1C, OR10J1, PRKACA, OR10A3, OR10A5, OR2W1, OR7E24",0.299296282854981,0.178486471595227,FALSE +"GSE12790","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.2506,-0.852,0.545,16339,0.98,"MTHFD1L, SHMT2, MTHFD1, MTHFR, MTR, ATIC, MTFMT, DHFR",0.263603497723358,0.00877392430750515,FALSE +"GSE12790","Log2FC","KEGG_OOCYTE_MEIOSIS",-0.1902,-0.657,0.965,18189,1,"PPP2CA, SKP1, ESPL1, ITPR1, CDC23, CALM1, ANAPC11, ADCY2, PPP2R5B, RPS6KA6, ADCY1, CUL1, CAMK2D, ANAPC13, CALML6, ANAPC2, ADCY9, MAPK3, ADCY6, PPP2R5A, PGR, AR",0.0154726866562074,0,FALSE +"GSE12790","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",-0.37146,-1.26,0.193,18528,0.754,"AGA, MANBA, MAN2C1, NEU4",0.714442690992226,0.122628654130226,FALSE +"GSE12790","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.3734,-1.26,0.183,17021,0.754,"NDUFS1, ATP6V1B1, NDUFA2, NDUFB8, PPA2, ATP6V1C2, NDUFA10, ATP6V1B2, ATP6V0C, ATP6V1G1, UQCRQ, COX6C, NDUFA6, COX5B, NDUFB3, COX8A, ATP6V0A1, ATP6V1A, ATP6V0B, NDUFC1, COX17, NDUFB2, NDUFA8, NDUFV3, NDUFB1, UQCR10, COX4I1, NDUFB10, NDUFS2, NDUFS3, COX8C, COX6B1, COX11, NDUFAB1, ATP6V1H, SDHC, NDUFA1, UQCRB, ATP6V0D1, NDUFA3, ATP6V0E2, ATP6AP1, COX7B",0.737548910269571,0.122628654130226,FALSE +"GSE12790","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.52024,1.51,0.0517,2541,0.224,"GALNT12, GALNT14, ST6GALNAC1, GALNT5, GCNT3, GALNT3, C1GALT1, GALNT2, GALNTL6",1.28650945690606,0.649751981665837,FALSE +"GSE12790","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.44723,1.29,0.15,1613,0.345,"IGFBP3, SERPINB5, SERPINE1, CDK6, GADD45A, CDKN2A, FAS, SFN, THBS1, PMAIP1",0.823908740944319,0.462180904926726,FALSE +"GSE12790","Log2FC","KEGG_PANCREATIC_CANCER",0.44612,1.29,0.14,3709,0.345,"RAC2, TGFA, TGFBR2, CDK6, EGFR, VEGFC, PIK3CD, PLD1, CDKN2A, TGFB2, AKT3, SMAD3, RALBP1, PIK3CG, TGFB1, KRAS, EGF, STAT1, BRCA2",0.853871964321762,0.462180904926726,FALSE +"GSE12790","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.56738,1.63,0.0292,1460,0.261,"BCAT1, VNN1, DPYD",1.53461714855158,0.583359492661719,FALSE +"GSE12790","Log2FC","KEGG_PARKINSONS_DISEASE",-0.26569,-0.896,0.561,17898,0.922,"UQCRQ, COX6C, NDUFA6, UBA1, COX5B, NDUFB3, COX8A, PPID, SLC18A2, NDUFC1, NDUFB2, NDUFA8, NDUFV3, SLC6A3, NDUFB1, UQCR10, COX4I1, NDUFB10, NDUFS2, NDUFS3, COX8C, COX6B1, SLC25A6, NDUFAB1, SLC25A31, SDHC, NDUFA1, UQCRB, NDUFA3, TH, COX7B",0.251037138743839,0.0352690789463706,FALSE +"GSE12790","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.48941,1.42,0.0981,3464,0.285,"CLDN1, TUBB6, HCLS1, TUBA4A, FYN, EZR, TUBB2B, PRKCA, TUBA8, ITGB1, ARPC1B, LY96, CD14, TUBB2A",1.00833099262005,0.54515513999149,FALSE +"GSE12790","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.45269,1.33,0.12,2240,0.335,"PTGS2, LAMC2, GSTP1, LAMB3, PPARG, RAC2, CXCL8, ETS1, COL4A1, MET, IL6, CCNA1, WNT10A, TGFA, BMP2, ITGA6, ITGA2, BIRC3, COL4A2, TGFBR2, CDK6, DAPK1, LAMA4, EGFR, VEGFC, COL4A6, LAMB1, WNT16, WNT11, ITGA3, PIK3CD, KIT, PLD1, LAMA3, CDKN2A, FOXO1, WNT7A, FAS, FZD10, FN1, FGF11, SMO, TGFB2, CDKN2B, TCF7L1, TCF7, CTNNA2, FZD6, CBLC, WNT5B, MMP1, CSF2RA, MMP2, STAT5A, RASSF5, AKT3, SMAD3, FZD2, PML, PPARD, GLI1, LAMC1, WNT9A, PRKCA, RALBP1, EPAS1, MMP9",0.920818753952375,0.474955192963155,FALSE +"GSE12790","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.34766,1.01,0.419,1596,0.622,"AKR1B1, UGT1A6",0.377785977033705,0.206209615309181,FALSE +"GSE12790","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.26351,0.767,0.79,7015,0.886,"PGM1, DERA, ALDOC, TALDO1, PGD, RBKS, TKTL2, PRPS2, ALDOB, PGM2",0.102372908709559,0.0525662781129492,FALSE +"GSE12790","Log2FC","KEGG_PEROXISOME",-0.24932,-0.857,0.612,19000,0.998,"CRAT, MLYCD, PEX1, PEX19, IDH2, ABCD1, BAAT, PEX16, DECR2, ACOX3, EPHX2, PEX11B, PMVK, ABCD2, CROT, ACSL1, ACOX2",0.213248577854439,0.000869458712628891,FALSE +"GSE12790","Log2FC","KEGG_PHENYLALANINE_METABOLISM",0.57311,1.67,0.0206,1512,0.227,"ALDH1A3, ALDH3A1, MAOA, IL4I1, ALDH3B1",1.68613277963085,0.643974142806877,TRUE +"GSE12790","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.22278,-0.78,0.789,18454,1,"DGKZ, ITPR1, DGKQ, PIP5K1C, CALM1, PIP4K2C, PI4KB, PLCD4, PLCG1, IPPK, INPPL1, PIK3C2B, PIP4K2A, CDIPT, CALML6, PI4KA, PLCB1, PIK3R1, INPP5J, PLCB4, PIK3R3",0.10292299679058,0,FALSE +"GSE12790","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.42209,-1.46,0.0798,18593,0.927,"EARS2, MMAB, HMOX1, UGT2B17, FECH, HCCS, BLVRA, UGT2B4, ALAD, UGT2B28, BLVRB",1.09799710864927,0.0329202658555029,FALSE +"GSE12790","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.48362,1.4,0.0873,4022,0.283,"PLTP, PPARG, OLR1, FABP5, ACSL5, LPL, ACSL4, SLC27A6, EHHADH, FABP6, MMP1, CYP27A1, CYP7A1, PPARD, SLC27A2, ME1, PPARA, GK2, SCD5, ACADL, ADIPOQ, SLC27A5, CYP4A11",1.05898575629443,0.54821356447571,FALSE +"GSE12790","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.48687,1.41,0.083,2816,0.283,"CYP7B1, AKR1C4, CH25H, CYP39A1, CYP27A1, CYP7A1, AMACR",1.08092190762393,0.54821356447571,FALSE +"GSE12790","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",0.52578,1.52,0.049,3092,0.244,"LCK, IL7R, ADA, IGLL1, TAP2, CD3E, TAP1, CD40, IL2RG, AIRE",1.30980391997149,0.612610173661271,TRUE +"GSE12790","Log2FC","KEGG_PRION_DISEASES",0.53937,1.56,0.0449,3872,0.231,"IL6, IL1A, CCL5, IL1B, PRNP, FYN, C1QA, LAMC1, EGR1, C9, PRKACG, C6",1.34775365899668,0.636388020107856,TRUE +"GSE12790","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.22079,-0.782,0.815,20763,1,"ANAPC13, AKT1, MAPK9, ANAPC2, ADCY9, MAPK3, ADCY6, PIK3R1, PIK3R3, PGR",0.0888423912600234,0,FALSE +"GSE12790","Log2FC","KEGG_PROPANOATE_METABOLISM",0.34971,1.01,0.427,2895,0.622,"LDHB, EHHADH, LDHAL6B, ALDH2",0.369572124974976,0.206209615309181,FALSE +"GSE12790","Log2FC","KEGG_PROSTATE_CANCER",0.27828,0.816,0.746,4028,0.834,"GSTP1, TGFA, EGFR, PIK3CD, FOXO1, TCF7L1, TCF7, AKT3, PIK3CG, KLK3, KRAS, EGF, SRD5A2, HSP90B1, NRAS, PDGFRB, NKX3-1, PDGFC",0.127261172527331,0.0788339493622613,FALSE +"GSE12790","Log2FC","KEGG_PROTEASOME",0.46925,1.37,0.0921,1070,0.297,"PSMB8, PSMB9, PSMA8",1.03574036980315,0.527243550682788,FALSE +"GSE12790","Log2FC","KEGG_PROTEIN_EXPORT",-0.39994,-1.38,0.0879,14755,0.986,"SEC61A1, SEC62, SPCS2, SRP14, IMMP1L, SRP19, SRPRB, SEC11C, SPCS1, OXA1L, SRPRA, SRP54, SEC61A2",1.05601112492623,0.0061230850587888,FALSE +"GSE12790","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.30385,0.877,0.613,5469,0.774,"CA2, SLC4A4, SLC9A3, ATP1B2, ATP1B3, GLS, ATP1B4, SLC38A3",0.212539525481585,0.111259039317107,FALSE +"GSE12790","Log2FC","KEGG_PURINE_METABOLISM",-0.17988,-0.638,0.944,17412,1,"POLR2B, POLD2, POLR2E, RRM1, GMPR2, POLA1, ADCY4, POLR1E, NT5M, NME4, PRUNE1, PDE3B, POLR2L, POLE3, PDE7A, POLA2, FHIT, POLR2G, GUCY1A2, ATIC, ADCY2, NUDT9, PDE6D, NME1, ALLC, ADCY1, POLR2I, PDE6C, ENTPD1, POLR3B, AK1, APRT, NME7, NME3, ADCY9, POLR3K, RRM2B, ENTPD2, ADCY6, ENPP1, AMPD1",0.025028005701931,0,FALSE +"GSE12790","Log2FC","KEGG_PYRIMIDINE_METABOLISM",0.2765,0.798,0.759,655,0.851,"CDA, NT5E, UPP1, CMPK2",0.11975822410452,0.0700704399154121,FALSE +"GSE12790","Log2FC","KEGG_PYRUVATE_METABOLISM",0.3826,1.12,0.295,2895,0.511,"LDHB, AKR1B1, ME3, ME1, LDHAL6B, ALDH2",0.530177984021837,0.291579099865287,FALSE +"GSE12790","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.34649,0.994,0.452,4422,0.637,"RAC2, ITGA4, ITGB4, ITGA6, MSN, ITGA2, EGFR, ITGB8, RRAS2, ITGA3, PIK3CD, MYL9, ITGB2, ITGA5, PAK3, MYH14, PAK6, FN1, FGF11, MYL2, EZR, PFN2, MYH10, PXN, ARHGEF4, ACTN4, CHRM5, CHRM4, ITGA1, GNG12, MYLPF, FGF21, PIK3CG, ITGB1, ARPC1B, RRAS, CHRM3, ITGAM, FGF2, ACTN1, RDX, CD14, PFN4, BAIAP2, KRAS, EGF, TIAM2, VAV1, DIAPH3, NRAS, DOCK1, PDGFRB, ARHGEF7, PDGFC, CFL2, MYL12A, FGF20, WASF2, CYFIP1, FGF3",0.344861565188618,0.19586056766465,FALSE +"GSE12790","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",0.22814,0.658,0.927,1810,0.935,"GABARAPL1, IFNA4, PRKAA1",0.0329202658555029,0.0291883891274822,FALSE +"GSE12790","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.38014,1.1,0.312,2664,0.526,"ETS1, MET, TGFA, VEGFC, PIK3CD, PAK3, PAK6, TGFB2, AKT3, EPAS1, PIK3CG, TGFB1",0.505845405981557,0.279014255846261,FALSE +"GSE12790","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.59035,1.75,0.0131,4325,0.269,"ENPEP, ANPEP, REN, ACE, ACE2, MME, MAS1",1.88272870434424,0.570247719997592,FALSE +"GSE12790","Log2FC","KEGG_RETINOL_METABOLISM",0.41972,1.24,0.17,5142,0.37,"DHRS3, LRAT, ALDH1A1, DHRS9, CYP26A1, UGT1A6, ALDH1A2, ADH1C, ADH1B, BCO1, ADH7, CYP4A11, DGAT1, CYP3A4, CYP2A7, ADH4, RDH10, CYP3A5, CYP2B6, CYP2C8",0.769551078621726,0.431798275933005,FALSE +"GSE12790","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",-0.28833,-0.995,0.409,18713,0.897,"FLAD1, ACP2, RFK, PHPT1, ENPP1",0.388276691992658,0.0472075569559079,FALSE +"GSE12790","Log2FC","KEGG_RIBOSOME",-0.13074,-0.462,1,2892,1,"RPL22L1, RPS8, RPLP2, RPS12, RPL3L, RPL14, RPS4Y1, RPL35A, RPL37, RPL38, RPS27, RPL27A, RPS27A, RPS28, RPS6, RPS7, RPS24, RPS16, RPL10L, RPL31, RPS10, RPL11, RPL8, RPS11, RPS15, RPL22, RPL3, RPL36, RPL10A, RPL12, RPL39, RPS5, RPS25, RPS3, RPS4X, RPL27, RPL7, UBA52, RPS17, RPL41, RPLP0, RPS18, RPL32, RPL6, RPL35, RPL9, RPL24, RPL18, RPL34, FAU, RPL30, RPL23A, RPS15A, RPL19, RPS9, RPL29, RPS21, MRPL13, RPLP1, RPS29, RPL37A, RPS19, RPL15, RPL26L1, RSL24D1, RPL36AL, RPS23, RPL36A, RPS27L",0,0,FALSE +"GSE12790","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.37469,1.1,0.299,3397,0.526,"CXCL8, ISG15, TNF, MAPK13, IFNA4, CXCL10, DHX58, IFNK, DDX58, IFIH1, IL12A, IFNE, IFNA7, CASP10",0.52432881167557,0.279014255846261,FALSE +"GSE12790","Log2FC","KEGG_RNA_DEGRADATION",-0.31115,-1.13,0.28,16761,0.799,"LSM4, PAPOLA, LSM7, DCP2, EXOSC1, CNOT8, HSPA9, EDC3, EXOSC5, EXOSC2, CNOT3, PARN, DCP1A, LSM5, WDR61, EDC4, MPHOSPH6, CNOT6, EXOSC6, LSM3, LSM1, DCP1B",0.552841968657781,0.0974532206860086,FALSE +"GSE12790","Log2FC","KEGG_RNA_POLYMERASE",-0.46291,-1.54,0.0833,15533,0.916,"POLR2K, POLR3GL, POLR3C, POLR2D, POLR3F, POLR2B, POLR2E, POLR1E, POLR2L, POLR2G, POLR2I, POLR3B, POLR3K",1.07935499859321,0.0381045263321496,FALSE +"GSE12790","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",0.22904,0.664,0.923,2923,0.943,"CTH, CBS, PAPSS2, TRMT11",0.0347982989740879,0.0254883072626717,FALSE +"GSE12790","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.5458,1.58,0.0226,1654,0.238,"PTGS2, LAMC2, LAMB3, COL4A1, ITGA6, ITGA2, BIRC3, COL4A2, CDK6, LAMA4, COL4A6, LAMB1, ITGA3, PIK3CD, LAMA3, FN1, CDKN2B, AKT3",1.6458915608526,0.623423042943488,TRUE +"GSE12790","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.26151,-0.902,0.523,15847,0.939,"STX4, VAMP1, STX3, SNAP47, BNIP1, STX5, STX6, STX12, STX17, VTI1B, VAMP7, STX16, SNAP29, STX18, BET1L, VAMP8, SEC22B",0.281498311132726,0.0273344077338891,FALSE +"GSE12790","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",-0.33412,-1.17,0.222,17742,0.798,"SPTLC1, SPTLC2, DEGS1, GLA, ACER1, ENPP7, ACER3, ARSA, PLPP3, NEU4, SPHK2, SMPD3, DEGS2",0.653647025549361,0.0979971086492706,FALSE +"GSE12790","Log2FC","KEGG_SPLICEOSOME",-0.27459,-0.94,0.481,15286,0.864,"SF3B4, SF3B1, SNRPB, RBM22, HNRNPU, SNRPF, DDX5, SLU7, SART1, CTNNBL1, ACIN1, DDX46, SNRNP27, LSM4, PRPF38B, SNRPD3, PQBP1, SNRPD2, LSM7, EFTUD2, PRPF38A, SNW1, ZMAT2, PLRG1, SRSF1, SRSF5, SNRPE, EIF4A3, PPIH, PRPF31, THOC2, TXNL4A, LSM5, PRPF19, RBM8A, PRPF3, HNRNPA1, BCAS2, PRPF6, USP39, SF3B3, CRNKL1, ALYREF, SRSF6, HSPA6, LSM3, DDX23",0.317854923626168,0.0634862575211067,FALSE +"GSE12790","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.38068,1.11,0.277,1596,0.517,"SI, PYGL, GYS2, MGAM, PGM1, UGT1A6",0.557520230935551,0.286509456906058,FALSE +"GSE12790","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.33548,0.974,0.5,2666,0.665,"SOAT1, LIPA, CEL",0.301029995663981,0.177178354696895,FALSE +"GSE12790","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.4259,1.24,0.181,5872,0.37,"AKR1C3, HSD17B2, CYP7B1, CYP11A1, AKR1C4, UGT1A6, CYP7A1, AKR1C1, CYP1B1, HSD17B8, SRD5A2, SRD5A1, CYP3A4, HSD3B2, CYP3A5, CYP11B1, CYP19A1, HSD17B12, UGT2A3",0.742321425130815,0.431798275933005,FALSE +"GSE12790","Log2FC","KEGG_SULFUR_METABOLISM",0.43183,1.26,0.155,2686,0.356,"CHST11, PAPSS2",0.809668301829709,0.448550002027125,FALSE +"GSE12790","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.49335,1.44,0.0671,3872,0.272,"C3, C1S, TNF, C1QA, C1R, CD40, ACTN4, HLA-DOB, HLA-DPA1, C9, CD86, ACTN1, HLA-DPB1, FCGR1A, HLA-DMA, CD28, C6",1.17327747983101,0.565431095965801,FALSE +"GSE12790","Log2FC","KEGG_TASTE_TRANSDUCTION",0.28366,0.828,0.733,6715,0.819,"TAS2R38, TAS1R1, GNAT3, TAS2R19, SCNN1A, SCNN1G, PRKACG, TAS2R45, ADCY8, ITPR3, TAS2R5, TAS2R50, TAS2R9, TAS2R13, PRKACA, TAS2R4, TAS2R40, GNB3, TAS2R16, CACNA1B",0.134896025358872,0.0867160982395816,FALSE +"GSE12790","Log2FC","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.62839,-2.12,0.0182,18955,0.263,"ADO, GGT6, BAAT, GGT5, CSAD, GAD1",1.73992861201493,0.580044251510242,FALSE +"GSE12790","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.34607,-1.18,0.24,17198,0.835,"MVK, FDPS, HMGCR, GGPS1, PMVK",0.619788758288394,0.0783135245163979,FALSE +"GSE12790","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.44802,1.32,0.13,5056,0.344,"INHBA, BMP2, TGFBR2, FST, TNF, ACVR1C, PITX2, INHBE, ID4, TGFB2, THBS1, ID1, CDKN2B, SMAD3, NOG, ID3, COMP, THBS2, TGFB1, SMURF2, TFDP1, BMP8B, TGFBR1, SMAD9, NODAL, THBS4, SMURF1, MYC, PPP2R1B",0.886056647693163,0.46344155742847,FALSE +"GSE12790","Log2FC","KEGG_THYROID_CANCER",0.38104,1.11,0.299,6276,0.517,"PPARG, TCF7L1, TCF7, KRAS, NRAS, MYC, CDH1, CTNNB1, TFG, TPR, TPM3, TCF7L2, NTRK1",0.52432881167557,0.286509456906058,FALSE +"GSE12790","Log2FC","KEGG_TIGHT_JUNCTION",0.38116,1.12,0.289,4243,0.511,"CLDN1, MYH4, GNAI1, RAB3B, CLDN11, AMOTL1, HCLS1, RRAS2, CLDN7, MYL9, MYH14, CLDN10, YBX3, CTNNA2, MYL2, CLDN6, AKT3, MYH10, PRKCA, ACTN4, MYLPF, LLGL1, RRAS, MYH15, CRB3, ACTN1, KRAS, PRKCI, NRAS, PATJ, VAPA, MYH7, MYL12A, YES1",0.539102157243452,0.291579099865287,FALSE +"GSE12790","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.45446,1.3,0.136,3291,0.361,"CXCL8, CXCL11, IL6, TLR1, CCL5, IL1B, TLR6, TLR2, TLR3, PIK3CD, TNF, MAPK13, IFNA4, AKT3, CXCL10, CD40, PIK3CG, TLR8, LY96, CD86, IL12A, IFNA7, MYD88, CD14",0.866461091629782,0.442492798094342,FALSE +"GSE12790","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",0.307,0.896,0.59,6835,0.742,"MAOA, IL4I1, EHHADH, HAAO, ACMSD, CAT, ALDH2, CYP1B1, KYNU, AFMID, ACAT2, ALDH3A2, TPH1, GCDH, ACAT1, OGDH, ALDH1B1",0.229147988357856,0.129596094720973,FALSE +"GSE12790","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",-0.29303,-1.02,0.395,20159,0.91,"GCK, IKBKB, MAPK9, MAPK3, PIK3R1, CACNA1D, KCNJ11, PIK3R3",0.40340290437354,0.0409586076789064,FALSE +"GSE12790","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",0.55418,1.62,0.0205,3798,0.258,"IL1A, IL1B, HLA-G, HLA-A, HLA-B, FAS, TNF, HLA-F, HLA-C, HLA-E, HLA-DOB, HLA-DPA1, CD86, HLA-DPB1, IL12A, HLA-DMA, CD28",1.68824613894425,0.58838029403677,FALSE +"GSE12790","Log2FC","KEGG_TYROSINE_METABOLISM",0.312,0.913,0.579,3048,0.721,"ALDH1A3, ALDH3A1, MAOA, IL4I1, ALDH3B1, ADH1C, TRMT11, ADH1B",0.237321436272564,0.142064735280571,FALSE +"GSE12790","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.29638,0.867,0.658,4534,0.78,"LCK, CARD11, CSF2, PIK3CD, PAK3, TNF, PAK6, MAPK13, IL5, CBLC, FYN, AKT3, CD3E, MAP3K14, PIK3CG, KRAS, VAV1, CBLB, NRAS, CD4, CD28, NFAT5, MAP3K8, DLG1, MAP2K7, LCP2, SOS1",0.181774106386044,0.10790539730952,FALSE +"GSE12790","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.16853,-0.569,0.982,18236,1,"UBA1, SKP1, UBE2F, UBE2Q1, CUL3, CDC23, TRIM32, UBR5, UBE2R2, STUB1, PRPF19, ERCC8, DDB1, ANAPC11, PIAS3, HERC1, TRIM37, PIAS2, FBXW7, PPIL2, PIAS4, NEDD4, CUL1, RCHY1, MGRN1, ANAPC13, WWP1, ANAPC2, MAP3K1, UBE2QL1",0.00788851221305034,0,FALSE +"GSE12790","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.66954,1.93,0.00248,41,0.14,"BCAT1",2.60554831917378,0.853871964321762,TRUE +"GSE12790","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.26469,0.765,0.786,2019,0.875,"BCAT1, IL4I1, EHHADH, OXCT1",0.104577453960592,0.0579919469776868,FALSE +"GSE12790","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.34404,1.01,0.428,4522,0.622,"CALML5, PLA2G4A, PPP1R14A, ADRA1B, CALD1, ADORA2B, ADCY7, MYL9, PLA2G1B, NPR2, PLA2G2F, PRKCA, AVPR1A, KCNMB3, KCNMB4, CACNA1S, ACTG2, ADCY3, PRKACG, CYP4A11, ADCY8, ADRA1D, ITPR3",0.368556230986828,0.206209615309181,FALSE +"GSE12790","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.19223,-0.669,0.923,19165,1,"DCTN4, DCTN5, RAB5B, RAB11A, ADCY9, ADCY6, CREB3L4",0.0347982989740879,0,FALSE +"GSE12790","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.4128,1.19,0.213,2099,0.436,"PTGS2, PLA2G4A, RAC2, KDR, PIK3CD, PLA2G1B, SH2D2A, MAPK13, AKT3, PLA2G2F, PXN, PRKCA",0.671620396561262,0.360513510731414,FALSE +"GSE12790","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.2223,-0.77,0.783,17432,1,"ATP6V1C2, ATP6V1B2, ATP6V0C, ATP6V1G1, GNAS, ATP6V0A1, ATP6V1A, ATP6V0B, PLCG1, ARF1, SEC61A2, ATP6V1H, ATP6V0D1, ADCY9, ATP6V0E2, ATP6AP1",0.106238237942057,0,FALSE +"GSE12790","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.57858,1.69,0.0155,3798,0.219,"CAV1, RAC2, MYH4, ICAM1, HLA-G, DMD, HLA-A, HLA-B, ITGB2, MYH14, CXADR, HLA-F, FYN, HLA-C, MYH10, CD40, HLA-E, HLA-DOB, HLA-DPA1, MYH15, CD86, HLA-DPB1, SGCB, HLA-DMA, CD28",1.80966830182971,0.659555885159882,TRUE +"GSE12790","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.35484,1.06,0.37,2099,0.577,"RAC2, FOSL1, WNT10A, VANGL2, SFRP1, DKK1, WNT16, WNT11, WNT7A, FZD10, MMP7, TCF7L1, TCF7, FZD6, WNT5B, SMAD3, FZD2, PPARD, WNT9A, PRKCA",0.431798275933005,0.238824186844269,FALSE +"GSE31625","Log2FC","KEGG_ABC_TRANSPORTERS",-0.50212,-1.56,0.0536,11075,0.38,"ABCC8, ABCC1, ABCB7, ABCG1, ABCC3, ABCA5, ABCB1, ABCA8, ABCG2, ABCA3, ABCB6, ABCC4, ABCC2",1.27083521030723,0.42021640338319,FALSE +"GSE31625","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.35103,1.06,0.332,1915,0.617,"PIK3R3, PIK3CA, TCF7L1, PPARD, KIT, LEF1, PML, MAPK3, RARA, CCNA1, PIM1, MAPK1, SOS1, SPI1",0.478861916295964,0.209714835966758,FALSE +"GSE31625","Log2FC","KEGG_ADHERENS_JUNCTION",0.41726,1.26,0.171,2002,0.655,"CDH1, RAC2, EGFR, FYN, AFDN, TCF7L1, WASF3, TGFBR2, PTPRF, LEF1, MAPK3, BAIAP2, YES1, ERBB2, WASL, MAPK1, CSNK2B, WASF2",0.767003889607846,0.183758700008217,FALSE +"GSE31625","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.34739,-1.04,0.348,10834,0.643,"IRS1, CPT1A, LEP, NFKBIB, TRAF2, PRKAA2, TNFRSF1A, CHUK, PRKCQ, ACSL4, AGRP, IKBKB, PCK1, PCK2, NPY, IRS2, PPARGC1A, ACACB",0.458420756053419,0.191789027075778,FALSE +"GSE31625","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.36242,1.11,0.272,630,0.648,"GAD1, GLUL, ABAT, GLS2",0.565431095965801,0.188424994129407,FALSE +"GSE31625","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.41733,1.25,0.175,1179,0.628,"PIK3R3, SCNN1A, ATP1A1, PIK3CA, NEDD4L, SLC9A3R2, SFN, NR3C2, HSD11B2, MAPK3",0.756961951313706,0.202040356262804,FALSE +"GSE31625","Log2FC","KEGG_ALLOGRAFT_REJECTION",0.55754,1.65,0.0491,1875,0.457,"HLA-DOB, HLA-C, HLA-B, HLA-DQB1, HLA-A, HLA-DRB1, HLA-E, TNF, HLA-G, HLA-DPA1, HLA-DRA, IL12A, HLA-F",1.30891850787703,0.34008379993015,FALSE +"GSE31625","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.56233,-1.71,0.0304,12571,0.321,"FADS2, PLA2G4A",1.51712641639125,0.493494967595128,FALSE +"GSE31625","Log2FC","KEGG_ALZHEIMERS_DISEASE",-0.25432,-0.771,0.752,10101,0.922,"LPL, NDUFA1, UQCRFS1, NDUFS1, GRIN2B, PPP3R1, CASP8, CALML5, ITPR1, NDUFA2, NDUFA4L2, APOE, CACNA1F, NDUFS2, COX7B, NDUFB1, PPP3CB, NDUFA7, CASP7, CASP9, APAF1, PSEN2, TNFRSF1A, GRIN2A, COX5A, ATP2A2, HSD17B10, CDK5R1, PPP3CC, MAPT, SNCA, APBB1, IDE, PLCB1, PLCB4",0.123782159408358,0.0352690789463706,FALSE +"GSE31625","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.56893,-1.73,0.0243,8704,0.33,"CARS2, FARS2, IARS2, HARS2, NARS2, SARS2, DARS2",1.61439372640169,0.481486060122112,FALSE +"GSE31625","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.35849,1.08,0.307,2325,0.627,"HK2, UAP1, HK1, NPL, PGM1, CYB5R3, NAGK, CHIA, CYB5R1, CMAS",0.512861624522813,0.202732459169284,FALSE +"GSE31625","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.29063,-0.901,0.56,11347,0.829,"BAX, CASP9, APAF1, PRPH2, BCL2, TNFRSF1A, GRIN2A, PPP3CC, PRPH, MAP2K6, NEFM, TP53, NEFL",0.2518119729938,0.0814454694497265,FALSE +"GSE31625","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.37187,1.13,0.251,2236,0.689,"HLA-DOB, CD74, HLA-C, HLA-B, TAPBP, HLA-DQB1, HLA-A, HLA-DRB1, HLA-E, RFXANK, CALR, HSPA1L, TAP2, KLRC3, HLA-G, HLA-DPA1, HLA-DRA, HLA-F, B2M, HSPA2",0.600326278518962,0.161780778092374,FALSE +"GSE31625","Log2FC","KEGG_APOPTOSIS",-0.24812,-0.766,0.784,10454,0.909,"PPP3R1, CASP8, PRKAR1A, PRKAR2B, IL3RA, EXOG, PPP3CB, CASP7, TRAF2, BAX, CASP9, APAF1, BCL2, TNFRSF1A, AIFM1, CHUK, TNFRSF10D, PIK3CG, IRAK4, IKBKB, PPP3CC, IRAK3, TNFRSF10B, PRKX, TP53",0.105683937315562,0.0414361167780325,FALSE +"GSE31625","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.49544,-1.51,0.071,11739,0.355,"ALOX12, PTGDS, CBR1, ALOX12B, CYP4F3, HPGDS, EPHX2, PTGS2, GPX2, AKR1C3, PLA2G4A",1.14874165128092,0.449771646944906,FALSE +"GSE31625","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.37696,-1.17,0.229,10881,0.527,"PYCR1, MAOA, GLUD1, ODC1, ALDH18A1, PRODH2, ALDH4A1, AGMAT, GOT1, ALDH3A2, GLUD2, ALDH1B1, NOS3, ALDH2, CPS1",0.640164517660112,0.278189384787453,FALSE +"GSE31625","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.27497,-0.827,0.667,12329,0.9,"CACNA2D2, DSG2, SGCB, CACNA2D3, CACNA2D1, SGCD, CDH2, GJA1",0.175874166083451,0.0457574905606751,FALSE +"GSE31625","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.58841,-1.79,0.0162,11899,0.343,"ALDH3A2, ALDH1B1, UGT2B28, ALDH2, UGDH",1.79048498545737,0.464705879957229,FALSE +"GSE31625","Log2FC","KEGG_ASTHMA",0.41641,1.26,0.175,1744,0.655,"HLA-DOB, HLA-DQB1, HLA-DRB1, TNF, HLA-DPA1, FCER1A, HLA-DRA",0.756961951313706,0.183758700008217,FALSE +"GSE31625","Log2FC","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.3665,1.1,0.293,1875,0.64,"HLA-DOB, HLA-C, HLA-B, HLA-DQB1, HLA-A, HLA-DRB1, HLA-E, HLA-G, HLA-DPA1, HLA-DRA, HLA-F",0.533132379645891,0.193820026016113,FALSE +"GSE31625","Log2FC","KEGG_AXON_GUIDANCE",0.41715,1.25,0.159,2676,0.628,"SEMA5A, RAC2, ABLIM3, PAK6, EFNB2, RHOD, FYN, EPHA1, EPHA4, EPHB3, EPHB6, LIMK2, PLXNA3, PAK1, EPHA2, SEMA3C, PLXNA2, RASA1, MAPK3, EFNA4, GNAI2, SEMA3E, EFNA3, PLXNB3, SEMA4A, PLXNA1, UNC5C, SEMA3D, EPHB2, MAPK1, PLXNB2, GNAI3, NFAT5, PPP3CA, SEMA4C, EPHB4, RAC1, NRP1, NFATC4, SEMA3F, PTK2, PAK2",0.798602875679548,0.202040356262804,FALSE +"GSE31625","Log2FC","KEGG_BASAL_CELL_CARCINOMA",0.34055,1.04,0.368,1669,0.61,"WNT4, BMP2, TCF7L1, WNT5A, WNT7B, WNT7A, LEF1, WNT5B, DVL3, WNT2, FZD1, FZD6",0.434152181326482,0.214670164989233,FALSE +"GSE31625","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.25522,-0.777,0.75,8728,0.934,"TBPL1, GTF2E1, TAF6, TAF6L, TAF5, GTF2H1, GTF2F1, TAF9B, GTF2A2, GTF2A1, TAF10, STON1, GTF2E2",0.1249387366083,0.0296531237699066,FALSE +"GSE31625","Log2FC","KEGG_BASE_EXCISION_REPAIR",-0.35632,-1.07,0.333,9962,0.606,"MPG, POLE3, POLL, OGG1, PARP2, PCNA, NTHL1, LIG3, NEIL3, APEX1",0.47755576649368,0.217527375833714,FALSE +"GSE31625","Log2FC","KEGG_BETA_ALANINE_METABOLISM",0.35546,1.07,0.314,717,0.635,"GAD1, ABAT, DPYD",0.503070351926785,0.197226274708024,FALSE +"GSE31625","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.65528,-2.02,0.00401,12516,0.217,"PECR, FADS2, SCD, ELOVL2, BAAT",2.39685562737982,0.66354026615147,TRUE +"GSE31625","Log2FC","KEGG_BLADDER_CANCER",0.46817,1.43,0.0931,1813,0.611,"CDH1, EGFR, THBS1, VEGFA, MMP1, CDKN2A, E2F1, MAPK3, ERBB2, VEGFB, MMP9, MMP2, MAPK1",1.03105031901866,0.213958789757446,FALSE +"GSE31625","Log2FC","KEGG_BUTANOATE_METABOLISM",-0.38026,-1.14,0.275,11801,0.532,"GAD2, ALDH3A2, ACADS, PDHA1, ALDH1B1, ACAT1, ALDH2, ACSM3, AKR1B10",0.560667306169737,0.274088367704952,FALSE +"GSE31625","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.43838,1.33,0.139,2982,0.679,"RAC2, CR2, PIK3R3, SYK, IFITM1, PIK3CA, JUN, BLNK, DAPP1, BCL10, MAPK3, VAV2, CD22, NFKBIA, MAPK1, SOS1, PTPN6, NFAT5, PPP3CA, VAV1, LYN, RAC1, NFATC4, FOS, MALT1, RELA, RAC3, NRAS",0.856985199745905,0.168130225719498,FALSE +"GSE31625","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.25497,-0.767,0.789,10230,0.919,"SLC25A4, TBXA2R, PDGFRA, VDAC1, SLC25A5, PHKA2, P2RX6, PPP3R1, CALML5, ITPR1, CACNA1F, P2RX5, PTGFR, RYR2, PPP3CB, P2RX1, CHRM5, DRD1, VDAC2, CACNA1H, ATP2B1, GRIN2A, F2R, ATP2A2, PHKA1, VDAC3, PRKCB, TRPC1, MYLK3, PPP3CC, CACNA1G, BDKRB1, ADRA1D, MYLK, AGTR1, CD38, NOS3, PDE1C, PLCB1, SLC25A6, PRKX, HTR2B, GNAL, BDKRB2, PLCB4, PDE1A, BST1",0.10292299679058,0.0366844886138887,FALSE +"GSE31625","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.27341,-0.843,0.67,9495,0.904,"COX7A2L, UQCRB, ATP1B3, COX5B, MYH7, MYL3, UQCRFS1, ACTC1, CACNA1F, COX7B, RYR2, CACNG2, TNNT2, CACNB2, COX5A, ATP2A2, CACNA2D2, CACNA2D3, TPM2, CACNA2D1, FXYD2",0.173925197299174,0.0438315695246367,FALSE +"GSE31625","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.48023,1.43,0.0949,1583,0.611,"CDH3, CLDN4, CLDN7, CDH1, CDH5, SDC4, SDC2, ICAM1, F11R, PECAM1, HLA-DOB, ITGA6, ITGB2, ICAM2, HLA-C, OCLN, HLA-B, ITGA4, HLA-DQB1, CD58, SDC3, GLG1, ICAM3, HLA-A, PTPRF, SELE, HLA-DRB1, HLA-E, ITGB8, CLDN9, CLDN3, CLDN8, CD22, HLA-G, HLA-DPA1, SDC1",1.02273378757271,0.213958789757446,FALSE +"GSE31625","Log2FC","KEGG_CELL_CYCLE",0.17128,0.529,0.994,2991,1,"CCNE2, CDKN2A, SFN, CDC20, MAD1L1, E2F1, HDAC1, RBX1, SKP2, CCNA1, CCNE1, CDC25A, CCNA2, RAD21, CDKN2B, CDK6, MCM2, MCM5, CCND1, BUB1B, CDKN1B, TTK, GADD45A, CDC45, YWHAB, YWHAH, YWHAZ, RBL2",0.00261361560268669,0,FALSE +"GSE31625","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.30287,-0.936,0.518,12566,0.798,"CCL7, GNB5, CXCL8, CCR7, CCL20, PLCB1, PF4, PRKX, CCL2, PLCB4, CXCL2, ARRB2, CXCL1, CXCL3, ELMO1, GNG11, CXCL5",0.285670240254767,0.0979971086492706,FALSE +"GSE31625","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.3077,0.942,0.517,2416,0.672,"CBLC, PIK3R3, PIK3CA, CDKN2A, TGFBR2, BCR, E2F1, HDAC1, MAPK3, MECOM, NFKBIA, MAPK1, SOS1, CDK6, CBLB, CTBP1, CCND1, CDKN1B",0.286509456906058,0.172630726946175,FALSE +"GSE31625","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.53958,1.57,0.0664,953,0.457,"BHLHE41, CSNK1E, PER3, CRY2",1.17783192063198,0.34008379993015,FALSE +"GSE31625","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.39839,-1.22,0.186,11383,0.491,"SUCLG2, OGDHL, FH, IDH3A, PDHA1, ACLY, PCK1, PCK2, IDH1",0.730487055782084,0.308918507877032,FALSE +"GSE31625","Log2FC","KEGG_COLORECTAL_CANCER",0.32142,0.968,0.458,1216,0.681,"RAC2, PIK3R3, PIK3CA, JUN, TCF7L1, TGFBR2, LEF1, MAPK3, RALGDS",0.339134521996131,0.166852888087215,FALSE +"GSE31625","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.53371,-1.63,0.0436,12676,0.331,"THBD, F2, C4BPA, CFD, TFPI, CPB2, C1R, C5AR1, BDKRB2, PROS1, C5, CFH, FGA, SERPINE1, C1S, FGB, FGG",1.36051351073141,0.480172006224281,FALSE +"GSE31625","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.37872,-1.15,0.252,9600,0.539,"LDHC, TRDMT1, BHMT, AHCY, SRM, DNMT3L, AMD1, MAT1A, APIP, LDHB, GOT1, CTH, LDHAL6B, MAT2A",0.598599459218456,0.268411234813261,FALSE +"GSE31625","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.2648,-0.802,0.717,11488,0.919,"IL17RB, PPBP, IFNA4, TNFRSF1A, CCL11, TNFRSF8, IL11RA, IFNB1, IFNA17, IFNA2, VEGFC, IL11, ACVR1, TNFRSF10D, TNFSF18, IL18R1, INHBE, CCR10, TGFBR1, EDA2R, IL18RAP, CCL7, TNFRSF11B, CSF2RA, CXCL8, CCR7, CCL20, FLT4, TNFRSF10B, PF4, IL18, LIF, BMPR1B, TNFSF9, CCL2, CXCL2, CXCL1, IL15, CD70, CXCL3, CXCL5",0.1444808443322,0.0366844886138887,FALSE +"GSE31625","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.27351,0.849,0.644,698,0.755,"DDX58, CCL5, CASP1, IL6, AIM2",0.191114132640188,0.122053048370812,FALSE +"GSE31625","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",0.2737,0.824,0.66,1624,0.784,"TNNC1, ITGA6, ITGA3, ITGA2, ITGA4, ITGB4, DMD, ITGB8, TNF, PRKACA, DAG1, ITGA1, ADCY8",0.180456064458131,0.105683937315562,FALSE +"GSE31625","Log2FC","KEGG_DNA_REPLICATION",-0.15507,-0.468,0.998,2057,0.999,"MCM2, MCM5, SSBP1, RFC1, RNASEH2A, LIG1, POLD3, POLA2, RPA3, POLD2, RFC4, RFC2, MCM3, PRIM2, FEN1, POLD1, POLE, RPA1, MCM4, DNA2, RFC5, MCM6, POLE2, RNASEH2B, RPA2, POLD4, RFC3, POLE3, MCM7, RNASEH1, RPA4, PRIM1, PCNA, POLA1",0.000869458712628891,0.000434511774017692,FALSE +"GSE31625","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.38923,1.18,0.194,2045,0.674,"EGFR, MAPK3, NOTCH2, ETV6, MAPK1, SOS1, ETV7",0.712198270069774,0.17134010346468,FALSE +"GSE31625","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.40502,-1.23,0.211,11906,0.488,"CYP3A43, GSTM4, FMO1, GSTO1, ADH6, GSTM2, GSTM1, UGT2B28, CYP3A5, ALDH3B1, GSTA4, GSTP1, ALDH3A1",0.675717544702307,0.311580177997289,FALSE +"GSE31625","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.33914,1.01,0.4,1936,0.638,"CDA, UPP1, UGT2B17, DPYD, UGT2B4, UCKL1, XDH",0.397940008672038,0.195179321278838,FALSE +"GSE31625","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.41761,1.26,0.172,910,0.655,"TNC, LAMB3, SDC4, LAMC2, LAMA3, THBS1, SDC2, HSPG2, ITGA6, ITGA3, ITGA2, ITGA4, ITGB4, CD36, CD47, CD44, LAMA4, SDC3, COL6A2",0.764471553092451,0.183758700008217,FALSE +"GSE31625","Log2FC","KEGG_ENDOCYTOSIS",0.45552,1.37,0.109,1493,0.622,"EPN3, CBLC, EGFR, SH3GL2, ARAP2, ADRB2, SMURF2, VPS37B, EHD1, RAB11FIP1, HLA-C, CSF1R, PRKCZ, HLA-B, PSD4, NEDD4L, PARD6B, ITCH, RAB31, LDLRAP1, PRKCI, ARRB1, EHD2, DNM3, SH3GLB2, CLTB, HLA-A, ASAP2, KIT, ARFGAP3, ERBB3, EHD4, AGAP1, HLA-E, GRK4, EPN1, ARFGAP2, RAB22A, HSPA1L, HLA-G",0.962573502059376,0.206209615309181,FALSE +"GSE31625","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.37083,1.11,0.267,1865,0.648,"CDH1, EGFR, PIK3R3, FOXO3, PIK3CA, TCF7L1, LEF1, MAPK3, ERBB2, MAPK1, SOS1",0.573488738635425,0.188424994129407,FALSE +"GSE31625","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.34798,1.05,0.349,2502,0.601,"MAPK13, EGFR, CCL5, F11R, HBEGF, JUN, PAK1, MAPK11, ATP6V0A4, MAPK14, NFKBIA, MAPK12, PTPRZ1, ADAM10, LYN, RAC1, ATP6V0D1",0.45717457304082,0.22112552799726,FALSE +"GSE31625","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.36627,1.12,0.277,1179,0.676,"CBLC, PAK6, TGFA, EGFR, PIK3R3, HBEGF, CAMK2G, PIK3CA, JUN, BTC, PAK1, ERBB3, MAPK3",0.557520230935551,0.170053304058364,FALSE +"GSE31625","Log2FC","KEGG_ETHER_LIPID_METABOLISM",-0.41253,-1.27,0.164,12708,0.491,"CHPT1, ENPP2, PLA2G4A",0.785156151952302,0.308918507877032,FALSE +"GSE31625","Log2FC","KEGG_FATTY_ACID_METABOLISM",-0.37325,-1.13,0.265,9169,0.539,"ADH7, ADH1C, ACSL6, ECHS1, ALDH7A1, HADHA, ACAA2, ECI1, CPT1A, EHHADH, ACADL, ECI2, ACSL4, ALDH3A2, ACADSB, ACADS, ADH6, ALDH1B1, ACAT1, ALDH2",0.576754126063192,0.268411234813261,FALSE +"GSE31625","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.40605,1.23,0.171,1900,0.604,"MAPK13, RAC2, PIK3R3, SYK, FYN, PRKCD, PIK3CA, PLA2G12A, MAPK11, MAPK3, TNF, VAV2, FCER1A, MAPK14, MAPK1, SOS1, MAPK12",0.767003889607846,0.218963061378868,FALSE +"GSE31625","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.38189,1.13,0.258,2650,0.689,"RAC2, PIK3R3, SYK, PRKCD, GSN, PIK3CA, LIMK2, MARCKS, PAK1, WASF3, MARCKSL1, DNM3, ASAP2, MAPK3, VAV2, PLPP3, SCIN, WASL, MAPK1, WASF2, ARPC1A, VAV1, LYN, RAC1, ARPC5L, VASP",0.58838029403677,0.161780778092374,FALSE +"GSE31625","Log2FC","KEGG_FOCAL_ADHESION",0.30583,0.927,0.519,910,0.682,"MYL9, TNC, LAMB3, RAC2, LAMC2, PAK6, LAMA3, EGFR, PIK3R3, PDGFC, THBS1, FYN, ITGA6, ITGA3, ITGA2, ITGA4, ITGB4, PIK3CA, JUN, VEGFA, LAMA4, PDGFB, PAK1, COL6A2",0.284832642151542,0.166215625343521,FALSE +"GSE31625","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.74246,2.21,0.00186,6,0.196,"ALPP",2.73048705578208,0.707743928643524,TRUE +"GSE31625","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.33459,-1.01,0.39,11561,0.68,"FBP2, MTMR6, KHK, PFKM, PFKFB3, AKR1B10",0.408935392973501,0.167491087293764,FALSE +"GSE31625","Log2FC","KEGG_GALACTOSE_METABOLISM",-0.38902,-1.17,0.237,11438,0.527,"B4GALT1, GALK2, PFKM, GAA, GLA, MGAM, GALK1",0.625251653989896,0.278189384787453,FALSE +"GSE31625","Log2FC","KEGG_GAP_JUNCTION",-0.33968,-1.03,0.371,12755,0.651,"PLCB1, SRC, PRKX, TUBB2B, HTR2B, TUBAL3, PLCB4, TUBA1A, GJA1",0.430626090384954,0.186419011431808,FALSE +"GSE31625","Log2FC","KEGG_GLIOMA",0.31617,0.954,0.45,1982,0.667,"TGFA, EGFR, PIK3R3, CAMK2G, PIK3CA, CDKN2A, PDGFB, E2F1, MAPK3, PDGFA, MAPK1, SOS1, CDK6",0.346787486224656,0.175874166083451,FALSE +"GSE31625","Log2FC","KEGG_GLUTATHIONE_METABOLISM",-0.44612,-1.37,0.126,11945,0.41,"GCLC, GSTM4, GSTO1, GCLM, GSTM2, GSTM1, IDH1, GSTA4, G6PD, GSR, PGD, GSTP1, GPX2",0.899629454882437,0.387216143280265,FALSE +"GSE31625","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",-0.35911,-1.1,0.285,11833,0.571,"GK, PNLIP, AGPAT4, ALDH3A2, PNLIPRP2, DGKI, ALDH1B1, ALDH2, GLA, DGKD, DGKG",0.54515513999149,0.243363891754152,FALSE +"GSE31625","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.31996,-0.98,0.423,11881,0.735,"AGPAT4, PTDSS2, ADPRM, CDS2, DGKI, PEMT, GPD1L, CHPT1, LPGAT1, DGKD, DGKG, PLA2G4A",0.373659632624958,0.133712660915805,FALSE +"GSE31625","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.38219,-1.16,0.257,10896,0.533,"MAOA, AOC2, SHMT2, CTH, AOC3, PSAT1, GLDC",0.590066876668705,0.273272790973428,FALSE +"GSE31625","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.36829,-1.11,0.278,12303,0.564,"PDHA1, LDHAL6B, PFKM, ADH6, ALDH1B1, ENO2, PCK1, PCK2, ALDH2, ALDH3B1, ENO3, ALDH3A1",0.555955204081924,0.248720896016658,FALSE +"GSE31625","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.38437,-1.17,0.232,11579,0.527,"B3GAT1, UST, CSGALNACT2, CHST7, CSGALNACT1",0.6345120151091,0.278189384787453,FALSE +"GSE31625","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.23939,0.732,0.839,2945,0.905,"NDST1, HS2ST1, HS3ST1, EXT1, XYLT1, XYLT2, EXT2",0.0762380391712997,0.0433514207947967,FALSE +"GSE31625","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.3471,1.05,0.339,2111,0.601,"ST3GAL1, B3GNT2, FUT8, CHST4",0.469800301796918,0.22112552799726,FALSE +"GSE31625","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.38847,-1.14,0.275,11225,0.532,"HYAL3, NAGLU, HPSE2, HEXA, HYAL1, HS3ST3A1",0.560667306169737,0.274088367704952,FALSE +"GSE31625","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.43871,1.32,0.144,733,0.667,"ST8SIA1, ST3GAL1, ST6GALNAC5",0.84163750790475,0.175874166083451,FALSE +"GSE31625","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.64803,2.03,0.00405,586,0.309,"B3GALNT1, ST8SIA1, FUT1, ST3GAL1, FUT9",2.39254497678533,0.510041520575165,FALSE +"GSE31625","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.63731,1.93,0.00595,1616,0.255,"ST8SIA1, B3GNT3, FUT3, FUT1, FUT6, FUT9, ST3GAL6, FUT4, ST3GAL4, B3GNT2",2.22548303427145,0.593459819566045,FALSE +"GSE31625","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.34702,-1.05,0.353,11337,0.634,"PIGL, PIGB, PGAP1, PIGN, PIGH, PIGF",0.452225294612177,0.197910742118267,FALSE +"GSE31625","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.41914,-1.26,0.176,7722,0.465,"ACO1, MDH1, MDH2, MTHFD2, HAO2, HAO1, MTHFD1, GRHPR, MTHFD2L",0.75448733218585,0.332547047110046,FALSE +"GSE31625","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.30737,0.942,0.5,1990,0.672,"MAPK13, EGFR, PRKCD, HBEGF, MAP3K1, CAMK2G, JUN, PLA2G12A, MAPK11, MAPK3, PRKACA, ADCY8, MAPK14, MMP2, MAPK1, ITPR3, ADCY6, SOS1, MAPK12, MAPK7",0.301029995663981,0.172630726946175,FALSE +"GSE31625","Log2FC","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.5758,1.74,0.0252,1875,0.418,"HLA-DOB, HLA-C, HLA-B, IL6, HLA-DQB1, HLA-A, HLA-DRB1, HLA-E, TNF, HLA-G, HLA-DPA1, HLA-DRA, HLA-F",1.59859945921846,0.378823718224965,FALSE +"GSE31625","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.42573,1.28,0.168,1620,0.698,"WNT4, CSNK1E, BMP5, GAS1, BMP2, WNT5A, WNT7B, BMP7, WNT7A, WNT5B, PRKACA, WNT2, IHH",0.774690718274137,0.156144577376839,FALSE +"GSE31625","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.46726,1.42,0.0925,1827,0.591,"MME, CD9, CR2, IL7R, ANPEP, ITGA6, IL4R, ITGA3, ITGA2, CSF1R, ITGA4, IL6, CD36, CD59, CD44, KIT, HLA-DRB1, TNF, CD22, ITGA1, HLA-DRA, GP9",1.03385826726097,0.228412519118745,FALSE +"GSE31625","Log2FC","KEGG_HISTIDINE_METABOLISM",-0.47052,-1.42,0.119,12408,0.405,"ALDH1B1, ALDH2, ALDH3B1, DDC, ALDH3A1",0.924453038607469,0.392544976785331,FALSE +"GSE31625","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",0.18071,0.55,0.992,3544,1,"RAD54L, XRCC3, SSBP1, POLD3, BRCA2, RPA3, POLD2",0.00348832784582135,0,FALSE +"GSE31625","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.26373,-0.815,0.715,10069,0.914,"CLTA, POLR2D, NDUFA1, UQCRFS1, SLC25A4, VDAC1, UCP1, NDUFS1, SLC25A5, GRIN2B, AP2B1, CASP8, ITPR1, NDUFA2, POLR2C, NDUFA4L2, NDUFS2, COX7B, NDUFB1, NDUFA7, VDAC2, AP2A2, BAX, CASP9, APAF1, DCTN2, COX5A, CLTCL1, VDAC3, POLR2L, PLCB1, SLC25A6, BDNF, PPARGC1A, PLCB4, TP53",0.145693958198919,0.0390538042661686,FALSE +"GSE31625","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.32397,0.982,0.434,1539,0.674,"TNNC1, ITGA6, ITGA3, ITGA2, ITGA4, IL6, ITGB4, PRKAA1, DMD, ITGB8, TNF, DAG1, ITGA1",0.362510270487489,0.17134010346468,FALSE +"GSE31625","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.25021,-0.774,0.793,12515,0.928,"MINPP1, IMPA1, PLCB1, PTEN, PLCB4",0.100726812682396,0.0324520237811379,FALSE +"GSE31625","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",-0.21791,-0.651,0.954,10067,0.982,"PKLR, PRKACB, PPP1CC, PYGB, ARAF, PRKAB1, CRK, PHKA2, HRAS, CALML5, PPP1CB, PRKAR1A, FLOT2, PRKAR2B, SOCS2, IRS1, SHC2, ACACA, PRKAA2, FBP2, EIF4EBP1, GYS2, PHKA1, FOXO1, PIK3CG, IKBKB, SHC1, SREBF1, PCK1, PCK2, PDE3B, PRKX, IRS2, PDE3A, PPP1R3C, RHOQ, PPARGC1A, ACACB",0.0204516252959049,0.00788851221305034,FALSE +"GSE31625","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.37379,1.12,0.278,1744,0.676,"TNFSF13, HLA-DOB, IL15RA, ITGA4, IL6, HLA-DQB1, HLA-DRB1, HLA-DPA1, HLA-DRA",0.555955204081924,0.170053304058364,FALSE +"GSE31625","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.23983,0.717,0.86,2362,0.919,"CBLC, PIK3R3, IL7R, IL4R, IL15RA, IL6, PIK3CA, GHR, IL20RA, SPRY1, IRF9, CTF1, SPRY2, PIM1, IL12A, SOS1, STAT2, CISH, SOCS1, PTPN6, CBLB, OSMR, MPL, CCND1",0.0655015487564323,0.0366844886138887,FALSE +"GSE31625","Log2FC","KEGG_LEISHMANIA_INFECTION",0.50269,1.52,0.0791,1900,0.508,"MAPK13, HLA-DOB, NCF4, ITGB2, NCF2, ITGA4, TLR2, TLR4, JUN, HLA-DQB1, MARCKSL1, MAPK11, HLA-DRB1, MAPK3, TAB1, TNF, HLA-DPA1, MAPK14, HLA-DRA, IL12A, NFKBIA, MAPK1, TAB2, MAPK12",1.10182351650232,0.294136287716081,FALSE +"GSE31625","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.5286,1.62,0.0513,1326,0.457,"CLDN4, CLDN7, MAPK13, CDH5, MYL9, RAC2, PIK3R3, ICAM1, F11R, PECAM1, NCF4, ITGB2, NCF2, OCLN, ITGA4, PIK3CA, AFDN, MAPK11, SIPA1, CLDN9, GNAI2, CLDN3, CLDN8, VAV2",1.28988263488818,0.34008379993015,FALSE +"GSE31625","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.6727,-2.06,0,9534,0.258,"ECHS1, ALDH7A1, HADHA, EHHADH, ALDH3A2, ALDH1B1, ALDH2",Inf,0.58838029403677,FALSE +"GSE31625","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",-0.59451,-1.79,0.0191,12816,0.343,"CYP3A5, PLA2G4A, AKR1B10",1.71896663275227,0.464705879957229,FALSE +"GSE31625","Log2FC","KEGG_LONG_TERM_DEPRESSION",-0.27569,-0.803,0.686,12677,0.929,"IGF1R, PLCB1, PLCB4, PLA2G4A",0.163675884293248,0.0319842860063582,FALSE +"GSE31625","Log2FC","KEGG_LONG_TERM_POTENTIATION",-0.24147,-0.737,0.835,9849,0.907,"MAP2K2, ADCY1, CAMK2B, PRKACB, PPP1CC, ARAF, GRIN2B, RPS6KA6, PPP3R1, HRAS, CALML5, ITPR1, PPP1CB, PPP3CB, RPS6KA3, GRIN2A, PRKCB, PPP3CC, PLCB1, PRKX, PLCB4",0.0783135245163979,0.0423927129399047,FALSE +"GSE31625","Log2FC","KEGG_LYSINE_DEGRADATION",-0.24811,-0.759,0.784,11191,0.911,"SUV39H1, EHHADH, OGDHL, ALDH3A2, AASS, ALDH1B1, ACAT1, ALDH2",0.105683937315562,0.0404816230270017,FALSE +"GSE31625","Log2FC","KEGG_LYSOSOME",0.31179,0.921,0.531,2320,0.676,"LAMP3, CTSH, CTSV, LAPTM5, FUCA1, CLTB, CTSE, AP1M2, AP1G1, ATP6V0A4, ACP5, PPT1, CTSA, AP3B2, SORT1, AP1B1, ACP2, PLA2G15, LAMP1, AP3S1, GGA1, MANBA, NAGA, NEU1, LAMP2, CTSO, CD164, AP1S1, SCARB2, GGA2",0.274905478918531,0.170053304058364,FALSE +"GSE31625","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",-0.22142,-0.672,0.909,12209,0.982,"IKBKB, PPP3CC, MAPT, CDC25B, TGFBR1, CACNA2D2, CACNA1G, CD14, MYC, FGF13, NR4A1, MAP3K8, CACNA2D3, MAP2K6, PRKX, CACNA2D1, MAP3K12, BDNF, DUSP4, DUSP1, FGFR4, TP53, ARRB2, FGF2, PLA2G4A",0.0414361167780325,0.00788851221305034,FALSE +"GSE31625","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.5346,-1.65,0.0418,11179,0.335,"MNX1, NKX6-1, HNF1A, NKX2-2, NR5A2, HNF1B, FOXA2, HHEX",1.37882371822496,0.474955192963155,FALSE +"GSE31625","Log2FC","KEGG_MELANOGENESIS",0.32292,0.968,0.462,1843,0.681,"WNT4, CAMK2G, TCF7L1, WNT5A, WNT7B, KIT, WNT7A, LEF1, CREB3L1, MAPK3, ASIP, WNT5B, GNAI2, DVL3, PRKACA, WNT2, ADCY8, FZD1, FZD6, GNAO1, MAPK1, ADCY6",0.335358024443874,0.166852888087215,FALSE +"GSE31625","Log2FC","KEGG_MELANOMA",0.34019,1.03,0.368,1179,0.609,"CDH1, EGFR, PIK3R3, PDGFC, PIK3CA, FGF12, CDKN2A, PDGFB, FGF9, E2F1, MAPK3",0.434152181326482,0.215382707367125,FALSE +"GSE31625","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.52093,-1.56,0.0492,11906,0.38,"CYP3A43, GSTM4, GSTO1, ADH6, GSTM2, GSTM1, UGT2B28, CYP3A5, ALDH3B1, EPHX1, AKR1C4, GSTA4, GSTP1, AKR1C3, AKR1C1, ALDH3A1",1.30803489723264,0.42021640338319,FALSE +"GSE31625","Log2FC","KEGG_MISMATCH_REPAIR",-0.21651,-0.664,0.952,8958,0.98,"MSH3, RPA2, POLD4, MLH3, RFC3, RPA4, MLH1, PCNA, EXO1",0.0213630516155257,0.00877392430750515,FALSE +"GSE31625","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.35175,1.06,0.336,1887,0.617,"PIK3R3, RPS6KA2, PIK3CA, VEGFA, PRKAA1, CAB39, MAPK3, VEGFB, MAPK1, RPS6KA1",0.473660722610156,0.209714835966758,FALSE +"GSE31625","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.36335,1.09,0.312,2225,0.633,"RAC2, PIK3R3, SYK, FYN, TNFSF10, ICAM1, ITGB2, ICAM2, HLA-C, HLA-B, PIK3CA, PAK1, HLA-A, MAPK3, HLA-E, TNF, VAV2, KLRC3, HLA-G, ULBP2, MICB, MAPK1, SOS1, SH3BP2, PTPN6, NFAT5, PPP3CA, VAV1, BID",0.505845405981557,0.198596289982645,FALSE +"GSE31625","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.29734,-0.908,0.52,9902,0.826,"NTSR2, OPRM1, GABRG2, GH1, S1PR4, CHRNB4, PARD3, APLNR, MC4R, GABBR1, MTNR1A, TBXA2R, LPAR4, GRIN2B, P2RX6, CHRNA9, GHRHR, DRD3, ADCYAP1R1, MC3R, NR3C1, SSTR1, P2RX5, GABRA6, SSTR2, PTGFR, MC2R, TSHR, HCRTR2, HCRTR1, PTH1R, GABRD, CHRNA3, PTGIR, LTB4R, ADRA2A, LEP, P2RX1, PTGER2, GLRA2, CHRM5, THRA, DRD1, GABRB2, GHSR, F2RL3, NPY5R, LPAR3, GNRHR, GRM8, TAAR5, GRIK4, GRIN2A, HRH3, GZMA, F2R, GRM2, P2RY1, GALR2, VIPR2, GRIA4, CHRM4, PLG, GPR50, FPR3, BDKRB1, ADRA1D, MCHR1, GABRA1, AGTR1, CALCRL, NPY1R, ADRA2C, CHRNA5, F2, F2RL2, HTR1D, LPAR6, C5AR1, HTR2B, GLP2R, BDKRB2, GABRB3, GABRA5",0.283996656365201,0.0830199526796178,FALSE +"GSE31625","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.35462,1.06,0.314,2064,0.617,"ARHGDIB, MAPK13, PIK3R3, PRKCD, FOXO3, RPS6KA2, MAP3K1, NGF, CAMK2G, PIK3CA, MAP3K5, JUN, MAPK11, MAPK3, SORT1, MAPK14, ZNF274, NFKBIA, MAPK1, SOS1, RAPGEF1, RPS6KA1, MAPK12, MAPK7, RAP1A, MAPKAPK2",0.503070351926785,0.209714835966758,FALSE +"GSE31625","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.51606,-1.55,0.0572,12473,0.368,"PNP, CD38, NT5C2, NAMPT, NT5M, NT5C, NADSYN1, BST1",1.24260397120698,0.434152181326482,FALSE +"GSE31625","Log2FC","KEGG_NITROGEN_METABOLISM",-0.57405,-1.73,0.0244,12041,0.33,"CTH, GLUD2, ASNS, CA8, CPS1, CA12",1.61261017366127,0.481486060122112,FALSE +"GSE31625","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.34318,1.05,0.353,1900,0.601,"MAPK13, CCL5, NOD2, CASP1, IL6, CASP5, MAPK11, MAPK3, TAB1, TNF, MAPK14, BIRC3, NFKBIA, MAPK1, TAB2, MAPK12",0.452225294612177,0.22112552799726,FALSE +"GSE31625","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",0.33044,0.988,0.426,448,0.673,"POLM",0.370590400897281,0.171984935776023,FALSE +"GSE31625","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.37798,1.15,0.241,1982,0.681,"TGFA, EGFR, PIK3R3, FOXO3, PIK3CA, CDKN2A, E2F1, MAPK3, ERBB2, MAPK1, SOS1, CDK6",0.617982957425132,0.166852888087215,FALSE +"GSE31625","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.33751,1.03,0.381,2644,0.609,"DTX4, JAG2, HDAC1, DVL3, NOTCH2, RBPJ, HES1, CTBP1, NCSTN, NOTCH3",0.419075024324381,0.215382707367125,FALSE +"GSE31625","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.15335,0.456,0.998,3795,0.999,"ERCC2, RBX1, RAD23A, RAD23B, ERCC6, RFC1, LIG1, CETN2, POLD3, RPA3, GTF2H5, POLD2, RFC4, GTF2H4",0.000869458712628891,0.000434511774017692,FALSE +"GSE31625","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.3702,1.11,0.299,3764,0.648,"MAN1A1, MGAT4A, ALG12, FUT8, MGAT1, RPN2, GANAB, DPM1, B4GALT3, ST6GAL1, DDOST, RPN1, MAN1B1, MGAT3, MAN2A1, B4GALT2, MOGS",0.52432881167557,0.188424994129407,FALSE +"GSE31625","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",-0.29413,-0.891,0.567,9187,0.839,"OR2B6, GUCA1A, OR7A10, OR2B2, OR2J2, OR2F2, OR2H1, OR10C1, OR1A2, OR51E2, CAMK2B, PRKACB, OR10H2, CLCA4, CALML5, OR2S2, OR1D5, OR1E1, PRKG2, OR52A1, PDC, CLCA1, OR10H3, PDE1C, PRKX, GNAL, ARRB2",0.246416941107093,0.0762380391712997,FALSE +"GSE31625","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.42185,-1.29,0.138,8382,0.474,"MTR, MTHFD2, ATIC, MTHFD1, AMT, SHMT2, MTHFD2L",0.860120913598763,0.324221658325915,FALSE +"GSE31625","Log2FC","KEGG_OOCYTE_MEIOSIS",-0.18961,-0.572,0.981,9903,1,"ADCY1, ADCY9, CDC16, CAMK2B, ANAPC13, PRKACB, PPP1CC, RPS6KA6, PPP3R1, CALML5, ITPR1, PPP1CB, ANAPC5, PGR, PPP3CB, PPP2CB, BTRC, SLK, RPS6KA3, MOS, SMC3, AR, SMC1A, PPP3CC, IGF1R, PRKX, CPEB1",0.0083309926200515,0,FALSE +"GSE31625","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",-0.29949,-0.924,0.519,9906,0.813,"MAN2B1, ENGASE, NEU3, AGA, MAN2C1, HEXA",0.284832642151542,0.0899094544059319,FALSE +"GSE31625","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.25779,-0.789,0.725,8668,0.922,"ATP6V1H, COX4I1, COX7A2, COX7C, ATP6V1G2, ATP6V1B2, NDUFS7, COX7A2L, UQCRB, COX5B, NDUFB8, NDUFA1, UQCRFS1, NDUFS1, COX10, NDUFA2, NDUFA4L2, NDUFS2, COX7B, NDUFB1, ATP6V0E2, NDUFA7, ATP12A, ATP6V1B1, COX5A, ATP4B, COX15, COX11, TCIRG1",0.139661993429006,0.0352690789463706,FALSE +"GSE31625","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.53622,1.61,0.0489,1634,0.428,"GALNT6, GALNT3, ST3GAL1, GALNT12, B4GALT5, C1GALT1, GALNT7, GALNT2",1.31069114087638,0.368556230986828,FALSE +"GSE31625","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.26261,0.791,0.742,1590,0.808,"SERPINB5, THBS1, IGFBP3, CCNE2, CD82, CCNG2, CDKN2A, SFN, PERP, RRM2, CCNE1",0.129596094720973,0.0925886392254138,FALSE +"GSE31625","Log2FC","KEGG_PANCREATIC_CANCER",0.41148,1.24,0.192,2000,0.603,"RAC2, TGFA, EGFR, PIK3R3, PIK3CA, VEGFA, CDKN2A, TGFBR2, E2F1, RALBP1, MAPK3, RALGDS, RALA, ERBB2, VEGFB, MAPK1, CDK6, RALB",0.71669877129645,0.219682687859849,FALSE +"GSE31625","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.24168,0.715,0.853,975,0.912,"DPYD, PPCS",0.069050968832477,0.0400051616715838,FALSE +"GSE31625","Log2FC","KEGG_PARKINSONS_DISEASE",-0.31637,-0.965,0.47,9495,0.757,"COX7A2L, UQCRB, COX5B, NDUFB8, SLC6A3, NDUFA1, UQCRFS1, SLC25A4, VDAC1, NDUFS1, SLC25A5, NDUFA2, SLC18A2, NDUFA4L2, NDUFS2, COX7B, SLC18A1, NDUFB1, UBA1, NDUFA7, VDAC2, CASP9, APAF1, COX5A, GPR37, VDAC3, SNCA, SLC25A6, UCHL1",0.327902142064283,0.120904120499927,FALSE +"GSE31625","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.29325,0.895,0.582,914,0.691,"CDH1, FYN, OCLN, TLR4, TLR5",0.235077015350112,0.160521952625802,FALSE +"GSE31625","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.31894,0.955,0.496,1813,0.676,"CDH1, CBLC, LAMB3, RAC2, LAMC2, TGFA, LAMA3, EGFR, PIK3R3, WNT4, ITGA6, ITGA3, ITGA2, CSF1R, IL6, PIK3CA, BMP2, CCNE2, JUN, VEGFA, LAMA4, PPARG, TCF7L1, WNT5A, MMP1, FGF12, CDKN2A, PDGFB, TGFBR2, WNT7B, FGF9, PPARD, BCR, KIT, WNT7A, LEF1, E2F1, PML, HDAC1, RBX1, RALBP1, MAPK3, RALGDS, WNT5B, SKP2, RARA, DVL3, WNT2, RALA, PDGFA, ERBB2, CCNA1, CCNE1, FZD1, VEGFB, FZD6, BIRC3, MECOM, MMP9, EGLN3, NFKBIA, MMP2, CDKN2B, MAPK1",0.304518323509803,0.170053304058364,FALSE +"GSE31625","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.40476,-1.26,0.16,12728,0.465,"UGT2B28, UGDH",0.795880017344075,0.332547047110046,FALSE +"GSE31625","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.41572,-1.26,0.17,11162,0.465,"GPI, PRPS1, FBP2, PFKM, TKT, TALDO1, G6PD, PGD",0.769551078621726,0.332547047110046,FALSE +"GSE31625","Log2FC","KEGG_PEROXISOME",-0.26862,-0.83,0.682,11595,0.906,"ACOX2, GNPAT, PHYH, ECI2, ACSL4, MLYCD, CRAT, PECR, IDH1, PEX6, EPHX2, SLC27A2, BAAT",0.166215625343521,0.0428718023231869,FALSE +"GSE31625","Log2FC","KEGG_PHENYLALANINE_METABOLISM",-0.48788,-1.49,0.0748,12309,0.345,"HPD, AOC3, ALDH3B1, DDC, ALDH3A1",1.12609840213554,0.462180904926726,FALSE +"GSE31625","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.24219,-0.74,0.828,11946,0.913,"CDS2, PIK3CG, PRKCB, DGKI, IMPA1, PLCB1, DGKD, DGKG, PTEN, PLCB4",0.0819696632151199,0.039529222465701,FALSE +"GSE31625","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.43593,-1.31,0.149,10536,0.474,"COX10, UGT2B15, UROS, HCCS, BLVRB, PPOX, COX15, FECH, UGT2B28, HMOX1",0.826813731587726,0.324221658325915,FALSE +"GSE31625","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",-0.30238,-0.909,0.53,10970,0.837,"CPT1A, PLTP, EHHADH, ACADL, ACOX2, ACSL4, GK, PCK1, PCK2, FADS2, ME1, SCD, SLC27A5, SLC27A2, FABP6",0.275724130399211,0.07727454200674,FALSE +"GSE31625","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.50073,-1.51,0.07,13042,0.355,"SLC27A5, AKR1C4, BAAT",1.15490195998574,0.449771646944906,FALSE +"GSE31625","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",0.2086,0.628,0.965,1471,1,"IL7R, BLNK, RFXANK, TAP2",0.0154726866562074,0,FALSE +"GSE31625","Log2FC","KEGG_PRION_DISEASES",0.31992,0.965,0.46,1315,0.677,"FYN, CCL5, IL6, EGR1, MAPK3, PRKACA",0.337242168318426,0.169411331314856,FALSE +"GSE31625","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.31779,0.959,0.46,1900,0.678,"MAPK13, PIK3R3, RPS6KA2, PIK3CA, MAPK11, MAPK3, GNAI2, PRKACA, CCNA1, ADCY8, MAPK14, CDC25A, CCNA2, MAPK1, ADCY6, RPS6KA1, MAPK12",0.337242168318426,0.168770306132937,FALSE +"GSE31625","Log2FC","KEGG_PROPANOATE_METABOLISM",-0.56459,-1.68,0.0354,9534,0.325,"ECHS1, ALDH7A1, LDHC, SUCLA2, SUCLG1, HADHA, LDHB, ACSS3, PCCA, EHHADH, ACACA, SUCLG2, HIBCH, ALDH3A2, MLYCD, LDHAL6B, ALDH1B1, ACAT1, ALDH2, ACACB",1.45099673797421,0.488116639021126,FALSE +"GSE31625","Log2FC","KEGG_PROSTATE_CANCER",0.30932,0.941,0.494,1865,0.664,"TGFA, EGFR, PIK3R3, PDGFC, PIK3CA, CCNE2, TCF7L1, PDGFB, LEF1, E2F1, CREB3L1, MAPK3, PDGFA, ERBB2, CCNE1, NFKBIA, MAPK1, SOS1",0.306273051076353,0.177831920631982,FALSE +"GSE31625","Log2FC","KEGG_PROTEASOME",-0.1817,-0.554,0.996,8415,1,"PSMD1, PSMC6, PSMD3, PSMC5, PSMA3, PSME3, PSMD13, PSMD14, PSME1, POMP, PSMA4, IFNG, PSMC4, PSMF1, PSMA1, PSMD11, PSMB5",0.00174066157630127,0,FALSE +"GSE31625","Log2FC","KEGG_PROTEIN_EXPORT",0.26497,0.8,0.731,2532,0.81,"SEC61G, SPCS3, SEC62, SEC61A1",0.13608262304214,0.0915149811213502,FALSE +"GSE31625","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.40071,-1.2,0.252,12404,0.512,"GLUD2, PCK1, PCK2, FXYD2",0.598599459218456,0.290730039024169,FALSE +"GSE31625","Log2FC","KEGG_PURINE_METABOLISM",-0.4116,-1.24,0.199,9680,0.486,"IMPDH1, IMPDH2, FHIT, POLR3C, ENTPD2, POLR2A, GUCY2F, ADCY1, ADCY9, PRPS2, NME4, POLE3, PKLR, POLR2D, POLR1E, POLR1B, ENPP3, APRT, POLR2C, RRM1, POLR3G, PRIM1, DGUOK, AK1, NME7, ADCY10, POLR3F, NME1, ITPA, PRPS1, PDE6B, PDE8A, ADPRM, POLA1, POLR3D, NPR1, PDE7B, ADA, PNP, POLR2L, PAPSS2, POLR1D, GMPR2, NPR2, NT5C2, PDE8B, PDE1C, PDE3B, AK5, NT5M, PDE3A, PFAS, NT5C, PDE10A, PDE1A, PDE4D, PDE4B",0.701146923590293,0.313363730737707,FALSE +"GSE31625","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.24377,-0.758,0.799,9807,0.902,"POLR3C, POLR2A, DHODH, NME4, POLE3, POLR2D, POLR1E, POLR1B, POLR2C, RRM1, POLR3G, CAD, PRIM1, NME7, POLR3F, NME1, ITPA, POLA1, POLR3D, TXNRD1, PNP, POLR2L, POLR1D, NT5C2, NT5M, NT5C",0.0974532206860086,0.0447934624580583,FALSE +"GSE31625","Log2FC","KEGG_PYRUVATE_METABOLISM",-0.61941,-1.91,0.0101,9330,0.289,"DLD, ALDH7A1, LDHC, HAGH, PDHB, PKLR, GRHPR, PDHA2, LDHB, ACACA, ALDH3A2, ME2, PDHA1, LDHAL6B, ALDH1B1, ACAT1, PCK1, PCK2, ME1, ALDH2, ACACB",1.99567862621736,0.539102157243452,FALSE +"GSE31625","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.29868,0.909,0.551,1633,0.672,"MYL9, RAC2, PAK6, TIAM1, EGFR, PIK3R3, PDGFC, ITGA6, ITGB2, ITGA3, ITGA2, ITGA4, GSN, ITGB4, PIK3CA, CHRM3, MYH9, LIMK2, FGF12, PDGFB, PAK1, FGF9, MAPK3, ITGB8, BAIAP2, SSH3, VAV2, PDGFA, MYH14, SCIN, ITGA1, PXN, PIP4K2C, SLC9A1",0.258848401148215,0.172630726946175,FALSE +"GSE31625","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.47475,-1.46,0.0974,10041,0.366,"GABARAP, IFNA7, PIK3C3, IFNG, ULK1, IFNA21, IFNA10, BECN1, PRKAA2, IFNA4, IFNA17, IFNA2, ULK2, ATG7",1.01144104312138,0.436518914605589,FALSE +"GSE31625","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.38801,1.15,0.241,2044,0.681,"PAK6, TGFA, PIK3R3, PIK3CA, JUN, VEGFA, PDGFB, PAK1, RBX1, MAPK3, VEGFB, EGLN3, MAPK1, SOS1, RAPGEF1, RAP1A",0.617982957425132,0.166852888087215,FALSE +"GSE31625","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.55001,1.67,0.0366,1528,0.479,"MME, ACE2, ANPEP, CTSA, REN",1.43651891460559,0.319664486585437,FALSE +"GSE31625","Log2FC","KEGG_RETINOL_METABOLISM",-0.4968,-1.5,0.0742,11825,0.349,"CYP26B1, CYP3A43, ADH6, BCO1, UGT2B28, CYP3A5, ALDH1A1",1.12959609472097,0.45717457304082,FALSE +"GSE31625","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",-0.27682,-0.84,0.639,9638,0.896,"FLAD1, ENPP3, ACP1, MTMR6, RFK",0.1944991418416,0.0476919903378748,FALSE +"GSE31625","Log2FC","KEGG_RIBOSOME",-0.50057,-1.53,0.0639,8425,0.373,"RPL14, RPL26L1, RPS12, RPL35, RPL37A, RPS17, RPS24, RPL6, RPS25, RPS27A, RPL32, RPL7, RPS28, RPL23A, RPS27, RPS15, RPL19, RPS19, RPL3, RPS29, RPS7, RPLP0, RPS6, RPL36AL, RPL31, RPS23, RPL27, RPL38, RPLP1, RPL30, RPL36, RPLP2, RPS4X, RPS16, RPS9, RPL10A, RPS11, RPL15, RPL27A, RSL24D1, RPL10L, RPS27L, RPS4Y1",1.1944991418416,0.428291168191312,FALSE +"GSE31625","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.3546,1.09,0.293,1900,0.633,"MAPK13, ISG15, DDX58, IFIH1, MAP3K1, MAPK11, DHX58, TNF, SIKE1, MAPK14, CYLD, IRF3, IL12A, NFKBIA, MAPK12",0.533132379645891,0.198596289982645,FALSE +"GSE31625","Log2FC","KEGG_RNA_DEGRADATION",-0.28893,-0.886,0.596,9430,0.825,"LSM8, LSM1, EXOSC8, PARN, WDR61, PAPOLG, PAPOLB, EXOSC2, CNOT7, HSPD1, DIS3, EXOSC5, HSPA9, ENO2, ENO3",0.224753740259764,0.0835460514500749,FALSE +"GSE31625","Log2FC","KEGG_RNA_POLYMERASE",-0.46002,-1.37,0.114,9807,0.41,"POLR3C, POLR2A, POLR2D, POLR1E, POLR1B, POLR2C, POLR3G, POLR3F, POLR3D, POLR2L, POLR1D",0.943095148663527,0.387216143280265,FALSE +"GSE31625","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",-0.44495,-1.33,0.16,9883,0.457,"SEPHS1, SCLY, AHCY, MAT1A, CTH, MAT2A, PAPSS2",0.795880017344075,0.34008379993015,FALSE +"GSE31625","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.26617,0.814,0.708,778,0.794,"LAMB3, LAMC2, LAMA3, PIK3R3, ITGA6, ITGA3, ITGA2, PIK3CA, CCNE2, LAMA4",0.149966742310231,0.100179497572904,FALSE +"GSE31625","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.2957,0.921,0.537,1271,0.676,"VAMP8, VAMP5, YKT6, STX3, STX5, SNAP29",0.270025714300444,0.170053304058364,FALSE +"GSE31625","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",-0.43182,-1.3,0.145,12846,0.474,"GLA, GALC, GAL3ST1",0.838631997765025,0.324221658325915,FALSE +"GSE31625","Log2FC","KEGG_SPLICEOSOME",0.15272,0.469,0.996,3592,1,"TRA2A, BCAS2, HSPA1L, WBP11, SNU13, LSM6, SNRPD3, HSPA2, SNRNP70, DHX38, PPIH, CHERP, NCBP2, HSPA6, DHX16, SRSF8, SF3B3, LSM2, THOC1, XAB2, RBM17, PRPF38B, PUF60, SF3A1, PRPF6, TXNL4A",0.00174066157630127,0,FALSE +"GSE31625","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.28711,-0.859,0.638,11952,0.878,"GYS2, GBE1, GAA, UGT2B28, MGAM, UGDH",0.195179321278838,0.0565054840938974,FALSE +"GSE31625","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.29153,0.872,0.61,295,0.727,"DHCR24",0.214670164989233,0.138465589140962,FALSE +"GSE31625","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.35894,-1.09,0.308,12728,0.578,"UGT2B28, HSD17B8, CYP3A5, AKR1C4, AKR1C3, AKR1C1",0.511449283499556,0.238072161579471,FALSE +"GSE31625","Log2FC","KEGG_SULFUR_METABOLISM",0.6538,1.99,0.00926,2471,0.257,"SULT1E1, SULT1A2, SULT1A1, SULT2B1, CHST11, CHST12",2.03338901331807,0.590066876668705,FALSE +"GSE31625","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.31901,-0.959,0.44,10222,0.757,"IL10, CD40LG, GRIN2B, C1QB, IFNG, TRIM21, HLA-DPB1, HLA-DMB, C7, SNRPB, GRIN2A, SSB, C1R, C5, C1S",0.356547323513813,0.120904120499927,FALSE +"GSE31625","Log2FC","KEGG_TASTE_TRANSDUCTION",-0.24684,-0.755,0.801,12388,0.897,"ASIC2, PRKX, PDE1A",0.0963674839157623,0.0472075569559079,FALSE +"GSE31625","Log2FC","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.41159,1.24,0.189,83,0.603,"GAD1",0.723538195826756,0.219682687859849,FALSE +"GSE31625","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.16562,-0.503,0.996,9291,1,"HMGCS2, PMVK, GGPS1, PDSS1, ACAT1",0.00174066157630127,0,FALSE +"GSE31625","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.25516,-0.793,0.74,11774,0.926,"SMAD6, ID1, ACVR1, E2F5, INHBE, TGFBR1, SMAD2, MYC, BMP6, FST, BMPR1B, ID3, ID2",0.130768280269024,0.0333890133180656,FALSE +"GSE31625","Log2FC","KEGG_THYROID_CANCER",0.41061,1.22,0.183,1179,0.604,"CDH1, PPARG, TCF7L1, LEF1, MAPK3",0.737548910269571,0.218963061378868,FALSE +"GSE31625","Log2FC","KEGG_TIGHT_JUNCTION",0.37831,1.15,0.25,1430,0.681,"CLDN4, CLDN7, MYL9, TJP2, PRKCD, F11R, TJP3, PRKCH, OCLN, PRKCZ, MYH9, PARD6B, AFDN, PRKCI, CLDN9, GNAI2, YES1, CLDN3, CLDN8, LLGL2, MYH14",0.602059991327962,0.166852888087215,FALSE +"GSE31625","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.30439,0.918,0.518,1900,0.672,"MAPK13, PIK3R3, CCL5, IL6, TLR3, PIK3CA, TLR2, TLR4, JUN, TLR5, MAPK11, MAPK3, TAB1, TNF, MAPK14, IRF3, IL12A, NFKBIA, MAPK1, TAB2, MAPK12",0.285670240254767,0.172630726946175,FALSE +"GSE31625","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",-0.45213,-1.37,0.12,10896,0.41,"MAOA, TDO2, EHHADH, OGDHL, HAAO, ALDH3A2, ALDH1B1, ACAT1, ALDH2, DDC, KYNU",0.920818753952375,0.387216143280265,FALSE +"GSE31625","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",0.43248,1.28,0.153,1276,0.698,"HK2, PIK3R3, PRKCD, PRKCZ, PIK3CA, HK1, MAPK3, TNF",0.815308569182401,0.156144577376839,FALSE +"GSE31625","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",0.5911,1.81,0.0139,1875,0.367,"GAD1, CPE, HLA-DOB, HLA-C, HLA-B, HLA-DQB1, HLA-A, HLA-DRB1, HLA-E, TNF, HLA-G, HLA-DPA1, HLA-DRA, IL12A, ICA1, HLA-F",1.8569851997459,0.435333935747911,FALSE +"GSE31625","Log2FC","KEGG_TYROSINE_METABOLISM",-0.45317,-1.39,0.0922,12309,0.43,"HPD, ADH6, AOC3, ALDH3B1, DDC, HGD, ALDH3A1",1.03526907894637,0.366531544420413,FALSE +"GSE31625","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.35907,1.08,0.296,3432,0.627,"MAPK13, CBLC, PAK6, PIK3R3, FYN, PIK3CA, JUN, BCL10, PAK1, MAPK11, MAPK3, TNF, VAV2, DLG1, MAPK14, NFKBIA, MAPK1, SOS1, MAPK12, PTPN6, NFAT5, PPP3CA, VAV1, CBLB, NFATC4, FOS, PAK2, PDPK1, MALT1, RASGRP1, RELA, PDCD1, NRAS, LCK, CTLA4, CSF2, PIK3R2, NCK2, PLCG1, KRAS",0.528708288941061,0.202732459169284,FALSE +"GSE31625","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.28291,0.866,0.622,2675,0.73,"CBLC, SMURF2, FBXO2, MAP3K1, NEDD4L, ITCH, UBE2L6, CDC20, FBXW7, PML, RBX1, SKP2, UBE2E3, UBE2C, CUL7, BIRC3, UBE2D4, UBE2G2, SMURF1, SOCS1, CBLB, BIRC2, PIAS3, UBE2H, UBE3A, UBR5",0.206209615309181,0.136677139879544,FALSE +"GSE31625","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.68608,-2.09,0.00864,9323,0.418,"IARS2, PDHB, BCAT2, PDHA2, PDHA1, BCAT1",2.06348625752111,0.378823718224965,FALSE +"GSE31625","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.29026,-0.89,0.584,9291,0.828,"HMGCS2, DLD, ECHS1, ALDH7A1, BCKDHA, AUH, HADHA, ACAA2, BCAT2, PCCA, EHHADH, HIBCH, ALDH3A2, ACADSB, HSD17B10, ACADS, BCAT1, ALDH1B1, ACAT1, ALDH2",0.233587152887601,0.0819696632151199,FALSE +"GSE31625","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.23446,-0.711,0.88,11756,0.939,"PRKCQ, ACTA2, PRKCB, MYLK3, NPR1, ADRA1D, MYLK, AGTR1, CALCRL, NPR2, PLCB1, PRKX, PLCB4, PLA2G4A",0.0555173278498314,0.0273344077338891,FALSE +"GSE31625","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.36455,1.1,0.304,1843,0.64,"ARHGDIB, CREB3L1, PRKACA, AQP3, DCTN5, ADCY6",0.517126416391246,0.193820026016113,FALSE +"GSE31625","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.30368,0.913,0.529,2204,0.673,"MAPK13, RAC2, PIK3R3, HSPB1, PIK3CA, PLA2G12A, VEGFA, MAPK11, MAPK3, MAPKAPK3, PXN, MAPK14, MAPK1, MAPK12, MAPKAPK2, NFAT5, PPP3CA",0.276544327964814,0.171984935776023,FALSE +"GSE31625","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",0.27459,0.83,0.686,2781,0.782,"TJP2, SEC61G, KDELR3, ATP6V0A4, PRKACA, KDELR2, ERO1A, GNAS, ATP6V0D1, SEC61A1, KDELR1, ATP6V0C",0.163675884293248,0.106793246940152,FALSE +"GSE31625","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.45369,1.37,0.123,1875,0.622,"RAC2, FYN, ICAM1, HLA-DOB, ITGB2, HLA-C, HLA-B, MYH9, HLA-DQB1, CXADR, HLA-A, HLA-DRB1, DMD, HLA-E, MYH14, HLA-G, DAG1, HLA-DPA1, HLA-DRA, HLA-F",0.910094888560602,0.206209615309181,FALSE +"GSE31625","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.26401,0.798,0.723,1952,0.804,"RAC2, DAAM1, WNT4, CSNK1E, CAMK2G, CTNNBIP1, JUN, TCF7L1, WNT5A, VANGL1, WNT7B, PPARD, WNT7A, LEF1, RBX1, TBL1XR1, WNT5B, DVL3, PRKACA, WNT2, FOSL1, LRP5, SENP2, FZD1, FZD6, PPP2R5C, PPP2R5B, CSNK2B, TBL1Y",0.140861702705469,0.0947439512515487,FALSE +"Coldren et al","Log2FC","KEGG_ABC_TRANSPORTERS",0.23561,0.688,0.916,7191,0.992,"ABCA12, ABCB8, ABCB9, ABCA13, ABCD1, ABCC3, ABCA1, ABCA2, ABCB11, ABCC10, ABCD4, ABCA4, ABCC5, ABCA5, TAP2, ABCC11, ABCG1, ABCB6, ABCG2",0.0381045263321496,0.00348832784582135,FALSE +"Coldren et al","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.36169,1.05,0.351,5916,0.767,"PIK3R2, IKBKB, MAPK3, RPS6KB2, PML, RARA, PIK3CA, JUP, STAT5B, STAT3, BRAF, RELA, TCF7L1, RUNX1, BAD, PIM1, PIK3R3, CCNA1, STAT5A, MAPK1, PIK3R5, PIK3CB, CEBPA",0.454692883534176,0.115204636051019,FALSE +"Coldren et al","Log2FC","KEGG_ADHERENS_JUNCTION",0.36058,1.03,0.404,3562,0.786,"NECTIN1, CTNND1, CDH1, ERBB2, BAIAP2, NECTIN4, PTPN1, RAC2, MAPK3, INSR, PTPN6, SNAI2, MET, IGF1R, EP300, EGFR, PTPRF, TCF7L1, PTPRB, SRC",0.393618634889395,0.104577453960592,FALSE +"Coldren et al","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.27558,0.803,0.768,5975,1,"TRADD, RXRA, CPT1B, PPARA, IKBKB, ACSL1, RXRB, CPT1C, ADIPOR1, IRS2, STAT3, PRKAA1, RELA, ACSL3, PRKAG2, PRKAB2, ACSL5, ACSL6, SLC2A1, MAPK10, IRS1, NFKBIA",0.114638779968488,0,FALSE +"Coldren et al","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.44972,1.3,0.115,3496,0.845,"GLUL, AGXT, GLS2, ASL, ABAT, ASS1, GPT, NIT2, IL4I1",0.939302159646388,0.0731432910503077,FALSE +"Coldren et al","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.37286,1.09,0.336,5894,0.732,"PIK3R2, SCNN1A, MAPK3, INSR, PIK3CA, SFN, SCNN1G, IRS2, NEDD4L, PIK3R3, SCNN1B, HSD11B2, MAPK1, PIK3R5, IRS1, PIK3CB",0.473660722610156,0.135488918941608,FALSE +"Coldren et al","Log2FC","KEGG_ALLOGRAFT_REJECTION",-0.23407,-0.825,0.717,16990,0.974,"PRF1, IL5",0.1444808443322,0.0114410431213845,FALSE +"Coldren et al","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.40981,1.18,0.194,3971,0.74,"PLA2G12A, PLA2G6, PLA2G4B, PLA2G10, PLA2G4E, ACOX1, PLA2G2C",0.712198270069774,0.130768280269024,FALSE +"Coldren et al","Log2FC","KEGG_ALZHEIMERS_DISEASE",0.24418,0.71,0.901,6624,0.999,"NDUFV1, CAPN1, CACNA1D, GRIN1, ATP2A3, CALML3, COX5B, LRP1, ATP5F1E, NDUFB7, MAPK3, CDK5, FADD, NDUFS8, EIF2AK3, NDUFA3, NDUFV2, COX6C, UQCR10, GRIN2A, APH1A, COX6B2, GRIN2D, CHP1, PPP3CA, SDHD, ADAM10, BAD, UQCR11, GNAQ, NDUFB4, NDUFAB1, APOE, CALML6, UQCRB, BACE2, NDUFA6, UQCRHL, ITPR3, NDUFA5, UQCRC1, NDUFB5, BID, MAPK1, CACNA1F, UQCRFS1, UQCRC2, PLCB3, COX6A1, GSK3B, NDUFA2, SNCA, APP, ERN1, CAPN2, ATP5PD, GRIN2C, NOS1, CHP2",0.045275209020937,0.000434511774017692,FALSE +"Coldren et al","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.55987,-1.88,0.0192,17343,0.262,"IARS2, MARS2, FARS2, FARSB, WARS2, RARS2, PSTK, YARS2",1.71669877129645,0.581698708680255,FALSE +"Coldren et al","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.51252,1.48,0.0387,5085,0.535,"HK2, MPI, GMPPA, NANP, GCK, PGM1, GMPPB, NPL, NAGK, GALT, CYB5R1, NANS, FPGT, HK1, GALE, UXS1, CYB5R3, HEXB, GNPDA1, AMDHD2, PGM2",1.41228903498109,0.271646217978772,FALSE +"Coldren et al","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.28452,0.821,0.756,4515,1,"CAT, CCS, CASP1, MAPK13, GRIN1, GRIN2A, GPX1, GRIN2D, CHP1, MAPK11, PPP3CA, BAD, MAP3K5",0.121478204498793,0,FALSE +"Coldren et al","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.26803,0.783,0.802,4719,1,"RFXANK, IFI30, TAPBP, CALR, CD74, CTSS, LGMN, CTSB, HSPA1B, B2M, CIITA, PDIA3, PSME1, CD4",0.0958256317158365,0,FALSE +"Coldren et al","Log2FC","KEGG_APOPTOSIS",0.28433,0.827,0.755,6624,1,"TRADD, IL1RAP, CAPN1, PIK3R2, ENDOD1, IKBKB, PIK3CA, MYD88, FADD, TNFSF10, CASP10, RELA, CHP1, PPP3CA, IRAK4, BAD, ENDOG, PIK3R3, NGF, PRKACA, IL1A, BID, CSF2RB, BAX, PIK3R5, PIK3CB, IL1R1, NFKBIA, PRKAR1B, DFFA, CAPN2, BCL2L1, CHP2",0.122053048370812,0,FALSE +"Coldren et al","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",0.38876,1.13,0.274,2694,0.707,"PLA2G12A, CYP4F3, CYP2E1, PTGES, PLA2G6, GGT7, PLA2G4B, LTC4S, PTGES2, EPHX2, CYP2J2, CYP4A22, PTGS1, PLA2G10, PLA2G4E, ALOX12B",0.562249437179612,0.150580586203101,FALSE +"Coldren et al","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.31866,0.927,0.564,5717,0.941,"GLUL, PYCR3, CKMT1A, CKMT1B, SAT2, NOS3, GLS2, ASL, ASS1, OAT, GATM, P4HA2, NAGS, PRODH, P4HA1, MAOA, AZIN2, ALDH4A1, GAMT",0.248720896016658,0.0264103765727431,FALSE +"Coldren et al","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.3651,1.06,0.339,3482,0.769,"ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, JUP, DSP, ITGA3, CACNB2, DAG1, DSG2, ITGA2B, DSC2, TCF7L1, PKP2",0.469800301796918,0.114073660198569,FALSE +"Coldren et al","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.50501,-1.8,0.00952,14596,0.187,"UGDH, MIOX, ALDH3A2, UGT2A1, ALDH1B1, ALDH7A1, ALDH9A1",2.02136305161553,0.728158393463501,TRUE +"Coldren et al","Log2FC","KEGG_ASTHMA",-0.34369,-1.22,0.202,17122,0.484,"IL13, EPX, IL5",0.694648630553376,0.315154638355588,FALSE +"Coldren et al","Log2FC","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.42092,-1.5,0.0333,16806,0.275,"IFNA21, PRF1, IFNA13, IL5, CTLA4",1.47755576649368,0.560667306169737,FALSE +"Coldren et al","Log2FC","KEGG_AXON_GUIDANCE",0.44776,1.29,0.118,5666,0.806,"EPHA1, PAK6, PLXNB2, EPHB3, PLXNB1, PLXNA3, SEMA4A, EFNA1, FES, SEMA3E, EFNA4, SEMA4B, RAC2, LIMK2, SEMA7A, EFNA3, SRGAP3, MAPK3, NTN4, RHOD, UNC5B, NTN1, PLXNB3, CDK5, EPHB4, MET, PLXNA2, EPHB6, SEMA3B, ABLIM3, NCK2, EPHB2, SEMA4F, SRGAP1, UNC5A, ABLIM2, EFNB3, EFNB1, ABLIM1, SEMA5B, CHP1, PPP3CA, PAK2, SEMA4C, SEMA4D, NGEF, SEMA3C, LIMK1, NCK1, SEMA5A, RASA1, RND1, ROBO3, RAC1, PAK1, PAK4, MAPK1, NFATC1",0.928117992693875,0.0936649581949093,FALSE +"Coldren et al","Log2FC","KEGG_BASAL_CELL_CARCINOMA",0.3741,1.09,0.322,4115,0.732,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, WNT4, DVL3, BMP2, WNT10A, GLI3, TCF7L1, FZD4, DVL2, WNT11",0.492144128304169,0.135488918941608,FALSE +"Coldren et al","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.36638,-1.28,0.129,18395,0.482,"TBPL1, TAF9B, TBP, GTF2H2, TAF9, TAF1L",0.889410289700751,0.31695296176115,FALSE +"Coldren et al","Log2FC","KEGG_BASE_EXCISION_REPAIR",0.30931,0.899,0.639,912,0.957,"SMUG1, POLD4, POLB",0.1944991418416,0.0190880622231565,FALSE +"Coldren et al","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.24897,-0.871,0.593,17472,0.913,"ALDH1B1, ALDH7A1, SMS, ALDH9A1",0.226945306635737,0.039529222465701,FALSE +"Coldren et al","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.30636,0.88,0.662,3986,0.967,"ACOT4, TECR, ACAA1, ELOVL6, ACOX1, SCD5",0.1791420105603,0.0145735259169983,FALSE +"Coldren et al","Log2FC","KEGG_BLADDER_CANCER",0.38783,1.12,0.297,4516,0.712,"CDH1, ERBB2, MMP9, TYMP, VEGFB, MAPK3, EGFR, E2F1, DAPK1, THBS1, FGFR3, BRAF, PGF, VEGFA, DAPK2",0.527243550682788,0.147520006363144,FALSE +"Coldren et al","Log2FC","KEGG_BUTANOATE_METABOLISM",0.28276,0.818,0.756,2472,1,"ABAT, HMGCL, BDH1, HMGCS1, ACADS, EHHADH",0.121478204498793,0,FALSE +"Coldren et al","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.39615,1.15,0.235,6959,0.71,"VAV1, BLNK, PIK3R2, PLCG2, DAPP1, RAC2, VAV3, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, IFITM1, CD72, CD79A, RELA, CD19, CHP1, PPP3CA, LYN, PIK3R3, RAC1, MAPK1, NFATC1, PIK3R5, PIK3AP1, PIK3CB, NFKBIA, GSK3B, FOS, SYK, NFATC4, GRB2, CHP2, INPP5D, BCL10, CD22",0.628932137728264,0.148741651280925,FALSE +"Coldren et al","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.29926,0.875,0.651,4406,0.97,"DRD5, PTAFR, BDKRB2, ERBB2, P2RX4, PLCG2, GNA15, CACNA1D, ERBB3, GRIN1, PLCD1, ATP2A3, CALML3, NOS3, CAMK2G, ADORA2B, ADORA2A, CACNA1I, ADCY4, BDKRB1, RYR1, PTK2B, EGFR, ATP2B4, SLC8A2, GRIN2A, PLCG1, SPHK2, PHKG1, ADRB2, GRIN2D, CHP1, P2RX6, PPP3CA, EDNRA, TNNC1, GNAS, GNAQ, P2RX2, LTB4R2, HTR7",0.186419011431808,0.0132282657337552,FALSE +"Coldren et al","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.27818,0.805,0.783,6162,1,"TNNI3, CACNA1D, CACNG1, COX5B, CACNB3, CACNG4, CACNB2, COX6C, UQCR10, COX6B2, TNNT2, TNNC1, SLC9A1, UQCR11, UQCRB, UQCRHL, UQCRC1, CACNA1F, UQCRFS1, UQCRC2, COX6A1",0.106238237942057,0,FALSE +"Coldren et al","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.37321,1.07,0.33,3535,0.748,"CDH3, NECTIN1, CDH1, CLDN8, ITGB2, CLDN9, CLDN7, CLDN4, F11R, ITGB8, CDH5, SDC1, ICOSLG, SDC4, CLDN18, ICAM3, CD6, GLG1, CLDN11, CD40, SELL, PTPRF, CLDN23, CD276, CLDN3",0.481486060122112,0.126098402135539,FALSE +"Coldren et al","Log2FC","KEGG_CELL_CYCLE",-0.36349,-1.25,0.182,15880,0.498,"ORC1, MCM4, PTTG2, CCNA2, ORC6, SMAD4, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, MCM3, ANAPC10, CDK6, CDC20, CDK1, SMC1A, CCNH, CCNB3, CDKN2C, CDC25A, TGFB1, ORC4, CCNB1, MCM6, PRKDC, TTK, CDC14A, CDKN2B, E2F2, BUB3, ORC2, CDC7, PTTG1, YWHAQ, HDAC2, SMC3, E2F5, ORC3, CDKN2A, E2F3, SMAD2, ANAPC13",0.739928612014925,0.302770657240282,FALSE +"Coldren et al","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.31904,0.922,0.585,4742,0.945,"CCR3, PRKCD, CCL22, STAT2, GRK7, VAV1, PIK3R2, FOXO3, GRK2, CX3CL1, RAC2, VAV3, CCL17, JAK3, CXCL10, IKBKB, MAPK3, CCL28, CCR2, ARRB1, VAV2, CCR7, ADCY5, PIK3CA, ADCY4, CXCL11, CXCL16, CCL5, PTK2B, STAT5B, RAP1A, CXCL9, CXCR2, STAT3, BRAF, ADCY6, RELA, TIAM1, PXN, GNB2, TIAM2, CCL26, CCL19, CXCL3, PRKCZ, CXCR6, WASL, LYN, PIK3R3, STAT1, CCR1",0.23284413391782,0.0245681914907371,FALSE +"Coldren et al","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.24297,0.702,0.913,6797,0.985,"CBLC, BCR, PIK3R2, IKBKB, MAPK3, PIK3CA, STAT5B, E2F1, CBLB, BRAF, CDKN1B, RELA, MECOM, RUNX1, BAD, PIK3R3, TGFB3, CRKL, STAT5A, TGFBR2, MAPK1, PIK3R5, PIK3CB, NFKBIA, CDKN1A, BCL2L1, GRB2, CTBP1, CCND1",0.039529222465701,0.00656376950238827,FALSE +"Coldren et al","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.41491,1.22,0.171,4027,0.678,"BHLHE41, NR1D1, CSNK1E, BHLHE40, PER3",0.767003889607846,0.168770306132937,FALSE +"Coldren et al","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29489,0.858,0.717,7287,0.984,"PC, IDH2, ACO2, IDH3B, SDHD, OGDHL, MDH1, MDH2, OGDH, IDH3G, IDH1, SUCLG2, SDHA",0.1444808443322,0.00700490156865849,FALSE +"Coldren et al","Log2FC","KEGG_COLORECTAL_CANCER",-0.17873,-0.589,0.988,14592,0.99,"KRAS, RAF1, LEF1, CASP9, BIRC5, AKT2, MAPK9, BCL2, MSH6, CASP3, MSH3, RHOA, APPL1, APC2, AKT3, SMAD4, PIK3R1, PIK3CG, MSH2, APC, TGFB1, TCF7, MAPK8, AXIN2, SMAD2",0.00524305541237188,0.00436480540245009,FALSE +"Coldren et al","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.26321,0.769,0.844,6969,1,"BDKRB2, F3, BDKRB1, VWF, FGA, FGG, CFB, PROC, C3, PLAU, CD59, SERPINA5, C2, PLAT, SERPINA1, C9, C1R, CFI, F8, CD55, C4A, SERPINF2, F12, FGB",0.073657553374345,0,FALSE +"Coldren et al","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.22246,-0.752,0.817,15262,1,"BHMT, ADI1, MTR, CDO1, GOT2, SRM, LDHB, MAT2A, AMD1, SMS, MTAP, TRDMT1",0.0877779434675845,0,FALSE +"Coldren et al","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33412,0.957,0.512,5572,0.883,"CCR3, IFNL3, IFNL1, CSF1R, CCL22, TNFSF13, IFNL2, IL1RAP, CRLF2, TNFRSF21, PDGFA, IL9R, BMP7, CX3CL1, TNFRSF18, CCL17, IL4R, VEGFB, CXCL10, LTBR, CCL28, CCR2, IFNLR1, EPOR, IFNB1, PDGFB, BMP2, CCR7, FLT3LG, MET, CXCL11, CXCL16, CCL5, TNFRSF25, EGFR, CTF1, ACVR1B, IL18, CD40, IL12B, CXCL9, TNFSF10, CXCR2, TNFRSF14, CLCF1, IL7R, EPO, CCL26, IL20RB, IL6R, IL6, NGFR, CCL19, CXCL3, IL20RA, TNFSF18, CXCR6, VEGFA, CSF2, TNFRSF12A, IL15RA, CCR1, LTB, IL12A, IL1R2, PRLR, TGFB3, CSF1, GH2, OSMR, INHBB, IL1A, VEGFC, EDAR, IFNGR1, TGFBR2, CXCL6, IL17RA, CSF2RB",0.290730039024169,0.0540392964224314,FALSE +"Coldren et al","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.36654,1.07,0.347,3908,0.748,"CASP1, MAVS, RIPK3, IRF3, CXCL10, IKBKB, IFNB1, CCL5, DDX58, IL18, PYCARD, RELA, IKBKE, IL6",0.459670525209126,0.126098402135539,FALSE +"Coldren et al","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",0.30112,0.873,0.669,4386,0.966,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ADCY5, ADCY4, ITGA3, CACNB2, DAG1, ITGA2B, ADCY6, TNNT2, TNNC1, GNAS, ITGA2",0.174573882232177,0.0150228735845067,FALSE +"Coldren et al","Log2FC","KEGG_DNA_REPLICATION",-0.44719,-1.57,0.0333,15778,0.271,"DNA2, RFC2, MCM4, RFC5, MCM3, RNASEH1, PRIM1, MCM6, RNASEH2B, PRIM2, POLE3, RFC1, RPA2, POLA1",1.47755576649368,0.567030709125594,FALSE +"Coldren et al","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.4409,1.28,0.131,5751,0.746,"ETV7, ETS2, MAPK3, ETV6, EGFR, NOTCH3, PIWIL2, NOTCH1, MAPK1, SPIRE1, SPIRE2",0.882728704344236,0.127261172527331,FALSE +"Coldren et al","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.47037,1.36,0.0814,3662,0.727,"ADH7, ALDH3B2, GSTK1, CYP2E1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, FMO4, MGST2, CYP2D6, UGT2B17, MGST3",1.0893755951108,0.138465589140962,FALSE +"Coldren et al","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.40437,1.17,0.221,3623,0.738,"XDH, TYMP, NAT1, UCKL1, CES2, UPP1, TK1, CDA, UGT2B17, TPMT, GUSB, ITPA",0.655607726314889,0.131943638176958,FALSE +"Coldren et al","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.39479,1.15,0.246,4629,0.71,"CHAD, LAMA3, ITGB6, LAMB3, ITGB8, SDC1, SDC4, CD47, TNC, LAMC2, GP6, ITGB4, CD44, AGRN, THBS3, VWF, ITGA3, DAG1, THBS1, ITGA2B, COL1A1, LAMA5, LAMB1, ITGA2, COL5A1, HSPG2",0.609064892896621,0.148741651280925,FALSE +"Coldren et al","Log2FC","KEGG_ENDOCYTOSIS",0.41396,1.2,0.194,5701,0.69,"EPN3, CHMP4B, CBLC, PSD4, CSF1R, ITCH, TRAF6, RAB11FIP4, CHMP2B, GRK7, FGFR2, RAB22A, PLD1, ARFGAP1, CHMP2A, GRK2, RAB5B, ARAP1, ERBB3, TFRC, ACAP1, EHD2, PLD2, SMURF1, VPS37C, ARRB1, CHMP5, PRKCI, CHMP3, RAB11FIP1, MET, MVB12A, SH3GLB2, IGF1R, CHMP6, VPS28, ARAP2, PARD6B, EGFR, EPN1, ARFGAP3, VPS37B, FGFR3, LDLRAP1, CXCR2, ARFGAP2, CBLB, EPS15, AP2M1, ADRB2, SRC, HSPA1B, CHMP4C, RAB11FIP5, AGAP1, ACAP2, PRKCZ, AP2A1, NEDD4L, ARAP3, PIP5K1C, STAMBP, CHMP1B, LDLR, ASAP2, HSPA2, IQSEC1, DNM2, RAB11B, RAB31, ARF6, RAB5C, VPS25, STAM2",0.712198270069774,0.161150909262745,FALSE +"Coldren et al","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.26466,0.764,0.834,3392,0.997,"CDH1, ERBB2, PIK3R2, FOXO3, MAPK3, PIK3CA, EGFR, BRAF, TCF7L1",0.0788339493622613,0.00130484168834428,FALSE +"Coldren et al","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.38362,1.11,0.297,6354,0.707,"MAPK13, PLCG2, F11R, ATP6V1C2, ATP6V0D2, ATP6V1B1, ATP6V1F, IKBKB, MET, CCL5, EGFR, ATP6AP1, CXCR2, PLCG1, RELA, SRC, MAPK11, NOD1, ADAM10, TCIRG1, LYN, ATP6V1G1, ATP6V0A4, RAC1, PAK1, MAPK10, ATP6V1C1, NFKBIA, TJP1, ATP6V1E1, IGSF5",0.527243550682788,0.150580586203101,FALSE +"Coldren et al","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.39525,1.15,0.231,5894,0.71,"GAB1, PAK6, CBLC, ERBB2, PIK3R2, PLCG2, ERBB3, CAMK2G, MAPK3, RPS6KB2, PIK3CA, NCK2, EGFR, STAT5B, BTC, CBLB, BRAF, PLCG1, CDKN1B, SRC, TGFA, PAK2, AREG, BAD, PIK3R3, NCK1, CRKL, STAT5A, PAK1, PAK4, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB",0.636388020107856,0.148741651280925,FALSE +"Coldren et al","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.38786,1.11,0.289,3971,0.707,"PLA2G12A, PLD1, PLA2G6, PLA2G4B, PLD2, LPCAT2, PLA2G10, PLA2G4E, PLPP3, LPCAT4, PLA2G2C",0.539102157243452,0.150580586203101,FALSE +"Coldren et al","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.38078,1.11,0.292,3627,0.707,"ADH7, ACAA1, CPT1B, GCDH, CYP4A22, ACSL1, CPT2, CPT1C, ACADS, EHHADH, ACOX1, ACSL3",0.534617148551582,0.150580586203101,FALSE +"Coldren et al","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.33886,0.966,0.508,2596,0.886,"PRKCD, PLA2G12A, VAV1, MAPK13, PIK3R2, PLCG2, RAC2, VAV3, PLA2G6, PLA2G4B, MAPK3, VAV2, PIK3CA, PLA2G10, PLA2G4E",0.294136287716081,0.0525662781129492,FALSE +"Coldren et al","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.40295,1.16,0.24,5894,0.755,"PRKCD, VAV1, PLD1, PIK3R2, PLCG2, RAC2, VAV3, LIMK2, PLA2G6, PLA2G4B, PLA2G4F, PLD2, MAPK3, RPS6KB2, VAV2, MARCKS, GSN, PIK3CA, PLA2G4E, PLCG1, PLPP3, SPHK2, WASL, LYN, PIK3R3, PIP5K1C, SPHK1, LIMK1, CRKL, SCIN, ASAP2, MYO10, DNM2, RAC1, PAK1, ARF6, MAPK1, PIK3R5, PIK3CB",0.619788758288394,0.122053048370812,FALSE +"Coldren et al","Log2FC","KEGG_FOCAL_ADHESION",0.30588,0.881,0.639,6359,0.975,"PAK6, CHAD, ERBB2, LAMA3, VAV1, ITGB6, PDGFA, PIK3R2, LAMB3, ITGB8, RAC2, VAV3, VEGFB, TNC, LAMC2, ITGB4, MAPK3, PPP1CA, VAV2, PDGFB, PIK3CA, PPP1CB, MET, IGF1R, THBS3, VWF, PDGFD, ITGA3, EGFR, RAP1A, THBS1, ITGA2B, BRAF, CAV2, PXN, COL1A1, SRC, CAV1, MYL9, ARHGAP35, PAK2, LAMA5, BAD, PGF, LAMB1, ITGA2, COL5A1, VEGFA, RASGRF1, PIK3R3, PIP5K1C, CRKL, MYL7, ARHGAP5, VEGFC, RAC1, PAK1, BCAR1, PAK4, MAPK1, MAPK10, PIK3R5, PIK3CB, PTEN, COL1A2, ITGA5, TLN2, GSK3B, COL6A1, DIAPH1, ITGA4, CAPN2",0.1944991418416,0.0109953843014632,FALSE +"Coldren et al","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.42522,1.24,0.153,5764,0.691,"ALPP, QDPR, SPR, FPGS",0.815308569182401,0.160521952625802,FALSE +"Coldren et al","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.5816,1.69,0.0144,3752,0.369,"ALDOC, PFKFB2, HK2, MPI, GMPPA, FBP1, GMPPB, PFKL, FBP2, MTMR1, FPGT, HK1, PFKFB4, ALDOA",1.84163750790475,0.43297363384094,FALSE +"Coldren et al","Log2FC","KEGG_GALACTOSE_METABOLISM",0.52612,1.53,0.0302,3636,0.483,"HK2, GCK, GAA, PGM1, PFKL, B4GALT1, GALT, GANC, HK1, B4GALT2, GLB1, GALE",1.51999305704285,0.316052869248488,FALSE +"Coldren et al","Log2FC","KEGG_GAP_JUNCTION",-0.17017,-0.6,0.991,15556,1,"ADRB1, TUBB3, ITPR2, MAP2K5, ADCY7, PRKX, TUBA1B, TUBB, GNAI1, ITPR1, TUBAL3, PRKACB, CDK1, PLCB4, PDGFRA, TUBA1A, NRAS, TUBB4A, TUBB2B, TUBB2A",0.00392634551472468,0,FALSE +"Coldren et al","Log2FC","KEGG_GLIOMA",0.26293,0.763,0.836,3686,0.991,"PDGFA, PIK3R2, PLCG2, CALML3, CAMK2G, MAPK3, PDGFB, PIK3CA, IGF1R, EGFR, E2F1, BRAF, PLCG1, TGFA",0.0777937225609836,0.00392634551472468,FALSE +"Coldren et al","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.33643,0.975,0.488,4600,0.87,"GSTK1, GGT7, GSTT2, GSTO2, GSS, IDH2, GSTZ1, GSTA3, OPLAH, MGST2, GGT6, GPX1, MGST3, ANPEP, G6PD, GPX3",0.311580177997289,0.0604807473813815,FALSE +"Coldren et al","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.17981,0.521,0.997,5968,0.997,"DGKA, LIPG, DGAT1, MGLL, TKFC, PLPP3, CEL, DGKH, AGPAT2, PNPLA3, DGKI, AWAT2, MBOAT1, DGKE",0.00130484168834428,0.00130484168834428,FALSE +"Coldren et al","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.36747,1.07,0.344,5053,0.748,"PISD, CDS1, PLA2G12A, CHKB, DGKA, PLD1, PLA2G6, PLA2G4B, PLD2, PCYT2, CHKA, LPCAT2, ETNK2, CDS2, PLA2G10, PLA2G4E, PLPP3, MBOAT7, LPCAT4, PLA2G2C, DGKH, AGPAT2, PGS1, LPCAT3, LYPLA2, ACHE, PCYT1A, DGKI",0.46344155742847,0.126098402135539,FALSE +"Coldren et al","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.31093,0.907,0.612,6983,0.956,"AGXT, GCAT, AOC2, GATM, SARDH, SHMT1, MAOA, AMT, GAMT, CTH, SDS, GNMT, AOC3, ALAS2, SRR",0.213248577854439,0.0195421077238999,FALSE +"Coldren et al","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.4334,1.25,0.143,1880,0.723,"LDHC, ADH7, ACSS2, ALDH3B2, ALDOC, HK2, ALDH1A3, GCK, ALDH3B1, FBP1, PGM1, GALM, PFKL",0.844663962534938,0.140861702705469,FALSE +"Coldren et al","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.43624,1.25,0.16,4160,0.723,"B4GALT7, CHPF, CHST12, XYLT2, CHST14, XYLT1, CHPF2, CHST11, CHST15",0.795880017344075,0.140861702705469,FALSE +"Coldren et al","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.45434,1.32,0.0981,3529,0.802,"B4GALT7, EXT1, HS3ST1, XYLT2, HS6ST1, NDST1, HS6ST2, XYLT1",1.00833099262005,0.0958256317158365,FALSE +"Coldren et al","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66703,1.93,0.0022,3600,0.282,"B3GNT7, CHST6, B4GALT4, B4GALT1, B3GNT2, CHST4, ST3GAL1, B4GALT2",2.65757731917779,0.549750891680639,FALSE +"Coldren et al","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.5591,1.61,0.0142,4196,0.378,"HGSNAT, NAGLU, HPSE, HYAL4, IDS, GALNS, HYAL2, GUSB, GLB1, HEXB",1.84771165561694,0.422508200162775,FALSE +"Coldren et al","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.42593,1.24,0.158,6306,0.691,"ST6GALNAC5, B3GALT4, SLC33A1, ST3GAL1, GLB1, HEXB, ST6GALNAC6, ST6GALNAC4, HEXA, ST8SIA1",0.801342913045577,0.160521952625802,FALSE +"Coldren et al","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.58271,1.68,0.0122,4276,0.327,"FUT2, FUT1, NAGA, B3GALNT1, ST3GAL1, GBGT1, A4GALT, HEXB, B3GALT5",1.91364016932525,0.485452247339714,FALSE +"Coldren et al","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.59777,1.74,0.00987,3600,0.327,"B3GNT3, ABO, FUT3, FUT2, B4GALT4, B3GNT5, B3GNT4, B4GALT1, FUT1, B3GNT2, ST3GAL4, B4GALT2",2.00568284733036,0.485452247339714,FALSE +"Coldren et al","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.50004,1.44,0.0522,3611,0.622,"PIGT, PIGU, GPAA1, PIGZ, PIGV, PIGQ, PIGL, PIGX, PIGS",1.28232949699774,0.206209615309181,FALSE +"Coldren et al","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.50461,-1.76,0.031,16224,0.183,"HYI, MTHFD2L, MTHFD2, ACO1, CS, MTHFD1L, HAO2",1.50863830616573,0.737548910269571,TRUE +"Coldren et al","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.34964,1,0.444,2596,0.835,"PRKCD, PLA2G12A, MAPK13, PLD1, CACNA1D, PLA2G6, CALML3, PLA2G4B, MAP3K4, PLD2, CAMK2G, MAPK3, MAP3K1, ADCY5, CGA, ADCY4, MMP14, PTK2B, PLA2G10, EGFR, PLA2G4E",0.35261702988538,0.0783135245163979,FALSE +"Coldren et al","Log2FC","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.20626,-0.725,0.875,3907,1,"IL6, IL1A, KLRC1, KIR2DL1, IL1B, KIR2DL3, KIR3DL2, CD86, FAS, CD80, IFNG, CD28, TNF, KLRD1, GZMB, FASLG, IL2, PRF1",0.0579919469776868,0,FALSE +"Coldren et al","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.36379,1.05,0.391,2621,0.767,"WNT3A, WNT9A, WNT7B, BMP7, WNT7A, WNT4, BMP2, CSNK1E, WNT10A, CSNK1A1, GLI3",0.407823242604133,0.115204636051019,FALSE +"Coldren et al","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.38485,1.14,0.254,6109,0.73,"CSF1R, IL9R, IL4R, TFRC, EPOR, FLT3LG, CD44, ITGA3, CD9, ITGA2B, CD19, IL7R, EPO, IL6R, IL6, ANPEP, CD59, ITGA2, CSF2, CD4, IL1R2, CSF1, IL1A, IL1R1, CD1D, CD55, ITGA5",0.595166283380062,0.136677139879544,FALSE +"Coldren et al","Log2FC","KEGG_HISTIDINE_METABOLISM",0.35152,1.02,0.403,1584,0.795,"ALDH3B2, HEMK1, HAL, ALDH1A3, ALDH3B1",0.39469495385889,0.0996328713435297,FALSE +"Coldren et al","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",0.23381,0.678,0.928,764,0.986,"POLD4, SEM1",0.0324520237811379,0.0061230850587888,FALSE +"Coldren et al","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.17121,-0.606,1,16664,1,"ITPR1, NDUFS4, BBC3, AP2S1, SOD1, COX6B1, COX7A2, DCTN4, AP2A2, PLCB4, ATP5F1C, NDUFA9, VDAC2, POLR2E, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, HDAC2, HIP1, TBPL1, TBP, UCP1, ATP5F1A, POLR2D, BDNF, NDUFS5, TFAM, GRIN2B",0,0,FALSE +"Coldren et al","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.30969,0.901,0.626,4437,0.962,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ITGA3, CACNB2, DAG1, ITGA2B, PRKAA1, ACE, TNNT2, IL6, TNNC1, ITGA2, PRKAG2",0.20342566678957,0.0168249279621871,FALSE +"Coldren et al","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.30094,0.869,0.684,6116,0.966,"PLCG2, INPP4B, PLCD1, INPP4A, ALDH6A1, PIK3CA, PIP4K2C, PLCG1, PIK3C2G, PIK3C2B, INPP5K, IMPA2, PIP5K1C, INPPL1, INPP5J, ISYNA1, PIK3CB, PTEN, PLCB3, IPMK",0.164943898279884,0.0150228735845067,FALSE +"Coldren et al","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.32542,0.949,0.531,6911,0.897,"CBLC, PPP1R3D, HK2, PTPN1, PIK3R2, GYS1, CALML3, SOCS1, MKNK1, GCK, IKBKB, MAPK3, RPS6KB2, FBP1, INSR, PPP1CA, SH2B2, PIK3CA, PPP1CB, PRKCI, TSC1, FBP2, IRS2, PTPRF, CBLB, BRAF, PRKAA1, PHKG1, HK1, FOXO1, PRKCZ, BAD, PRKAG2, INPP5K, EXOC7, PIK3R3, FASN, PYGL, CALML6, CRKL, PRKAB2, PRKACA, RHEB, PPP1R3B, MAPK1, FLOT2, MAPK10, PIK3R5, IRS1, PIK3CB, PRKAR1B, GSK3B, PHKG2, TRIP10, GRB2, INPP5D, PYGB, PRKAG1, TSC2, RPTOR",0.274905478918531,0.0472075569559079,FALSE +"Coldren et al","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.3125,0.916,0.603,3908,0.941,"TNFSF13, ICOSLG, LTBR, CCL28, CD40, PIGR, IL6",0.219682687859849,0.0264103765727431,FALSE +"Coldren et al","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.33678,0.982,0.455,5894,0.859,"IFNL3, IFNL1, CBLC, STAT2, IFNL2, CRLF2, PIK3R2, IL9R, IRF9, JAK3, IL4R, SOCS1, CISH, IFNLR1, EPOR, PTPN6, IFNB1, PIK3CA, TYK2, EP300, STAT6, CTF1, STAT5B, IL12B, CBLB, STAT3, CLCF1, IL7R, EPO, IL20RB, IL6R, IL6, PIAS3, IL20RA, PIM1, CSF2, PIK3R3, SPRY1, IL15RA, STAT1, IL12A, PRLR, GH2, STAT5A, OSMR, IFNGR1, JAK1, CSF2RB, STAM2, PIK3R5, PIK3CB",0.341988603342888,0.0660068361687577,FALSE +"Coldren et al","Log2FC","KEGG_LEISHMANIA_INFECTION",0.42556,1.24,0.175,6358,0.691,"TRAF6, ITGB2, NCF4, MAPK13, MAPK3, PTPN6, MYD88, IL12B, TAB1, RELA, MAPK11, C3, TLR2, IRAK4, STAT1, IL12A, TGFB3, IL1A, IFNGR1, JAK1, TAB2, MAPK1, NFKBIA, FOS, ITGA4",0.756961951313706,0.160521952625802,FALSE +"Coldren et al","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.41873,1.21,0.176,3793,0.675,"CTNND1, CLDN8, ITGB2, MMP9, CLDN9, VAV1, NCF4, CLDN7, MAPK13, PIK3R2, PLCG2, CLDN4, F11R, CDH5, RAC2, VAV3, VAV2, CLDN18, PIK3CA, RASSF5, PTK2B, RAP1A, CLDN11, RAPGEF3, PLCG1, SIPA1, PXN, CLDN23, CLDN3, MYL9, MAPK11, ARHGAP35",0.75448733218585,0.170696227168975,FALSE +"Coldren et al","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.42081,-1.51,0.0654,15341,0.301,"ALDH3A2, HADHA, YOD1, ALDH1B1, ALDH7A1, ALDH9A1",1.18442225167573,0.521433504406157,FALSE +"Coldren et al","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",0.40266,1.15,0.249,2596,0.71,"PLA2G12A, CYP2E1, PLA2G6, PLA2G4B, CYP2J2, PLA2G10, PLA2G4E",0.603800652904264,0.148741651280925,FALSE +"Coldren et al","Log2FC","KEGG_LONG_TERM_DEPRESSION",0.24312,0.706,0.906,6599,0.989,"PLA2G12A, GNAO1, PLA2G6, PLA2G4B, MAPK3, IGF1R, RYR1, PLA2G10, PLA2G4E, BRAF, PLA2G2C, GNAS, GNAQ, LYN, ITPR3, MAPK1, PLCB3, PPP2R1A, GUCY1A1, NOS1, PLA2G2F, GUCY1B1, GNA12",0.0428718023231869,0.0048037084028206,FALSE +"Coldren et al","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.23447,0.686,0.938,5774,0.986,"GRIN1, CALML3, CAMK2G, MAPK3, PPP1CA, PPP1CB, EP300, RAP1A, RAPGEF3, GRIN2A, BRAF, GRIN2D, CHP1, PPP3CA, GNAQ, RPS6KA2, CALML6, ITPR3, PRKACA, MAPK1, RPS6KA1",0.0277971616209356,0.0061230850587888,FALSE +"Coldren et al","Log2FC","KEGG_LYSINE_DEGRADATION",0.22598,0.645,0.958,2472,0.99,"BBOX1, KMT5B, KMT5C, GCDH, AASDH, EHHADH",0.0186344909214556,0.00436480540245009,FALSE +"Coldren et al","Log2FC","KEGG_LYSOSOME",0.52683,1.52,0.0349,5277,0.466,"CTSH, GM2A, CTSA, CTSV, HGSNAT, SLC11A1, NAGLU, GGA2, CTSD, ARSA, ATP6V0D2, LIPA, DNASE2, ABCB9, SUMF1, GAA, MANBA, NPC1, NAGA, ACP5, PSAP, IDS, GNPTG, NPC2, AP1M2, GALNS, CTSS, LAPTM4A, NAPSA, AP1B1, AP3M2, GGA1, LGMN, NEU1, TPP1, ATP6AP1, PSAPL1, ASAH1, LAMP3, CD68, CTSB, LAMP1, CLN5, GUSB, GLB1, GGA3, AP3S2, LAMP2, FUCA1, NAGPA, SCARB2, CTSE, HEXB, PPT1, AP1S1, TCIRG1, MAN2B1, CD63, SLC11A2, MFSD8, ABCA2, CTSZ, SORT1, AP1S3, ATP6V0A4, ENTPD4, GBA",1.45717457304082,0.33161408331,FALSE +"Coldren et al","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",0.26798,0.771,0.828,5856,1,"NTF4, PLA2G12A, TRAF6, FGF11, FGFR2, MAPK13, PDGFA, CACNA1D, RAC2, CACNG1, PLA2G6, PLA2G4B, MAP3K4, MKNK1, DUSP9, CACNB3, HSPB1, CACNG4, IKBKB, MAPK3, ARRB1, MAP4K1, MAP3K1, PDGFB, CACNA1I, FGF1, DUSP3, MAPK8IP2, MAX, NTRK2, PLA2G10, EGFR, CACNB2, PLA2G4E, MAP3K11, MAPKAPK3, RAP1A, JUND, ECSIT, MAP3K6, TAB1, LAMTOR3, FGFR3, MAP3K13, TAOK3, BRAF, DUSP10, RELA, STK3, DUSP14, CHP1, HSPA1B, MAPK11, PPP3CA, PAK2, PLA2G2C, MECOM, MAP3K8, GADD45B, RASGRF1, FGF12, MAP4K2, MAP3K5, RPS6KA2, IL1R2, RASA1, RPS6KA4, MAPKAPK2, NF1, STK4, TGFB3, CRKL, PPM1A, HSPA2, NGF, PRKACA, IL1A, RAC1, PAK1, MAP4K3, TGFBR2, RRAS, TAB2, MAPK1, DUSP8, MAP2K7, NLK, GADD45A, RPS6KA1, MAPK10, MAPK8IP3, CACNA1F",0.0819696632151199,0,FALSE +"Coldren et al","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26478,0.762,0.824,1432,0.985,"HES1, GCK",0.0840727883028842,0.00656376950238827,FALSE +"Coldren et al","Log2FC","KEGG_MELANOGENESIS",0.36219,1.04,0.393,6175,0.766,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, GNAO1, CALML3, WNT4, DVL3, CAMK2G, MAPK3, ADCY5, WNT10A, ADCY4, EP300, ADCY6, TCF7L1, FZD4, CREB3L4, DVL2, WNT11, GNAS, GNAQ, CALML6, CREB3L3, MITF, PRKACA, ASIP, CREB3L2, MAPK1, EDN1, CREB3L1, WNT5A, PLCB3, FZD6, GSK3B",0.405607449624573,0.115771230367396,FALSE +"Coldren et al","Log2FC","KEGG_MELANOMA",-0.26432,-0.889,0.51,16564,0.929,"PIK3R1, PIK3CG, FGF20, CDK6, FGF21, FGF2, PDGFRA, E2F2, NRAS, IGF1, FGF9, FGF4, CDKN2A, FGF5, FGFR1, E2F3, FGF19, FGF3",0.292429823902064,0.0319842860063582,FALSE +"Coldren et al","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.45636,1.33,0.0793,3662,0.805,"ADH7, ALDH3B2, GSTK1, DHDH, CYP2E1, CYP1B1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, MGST2, UGT2B17, MGST3",1.1007268126824,0.0942041196321315,FALSE +"Coldren et al","Log2FC","KEGG_MISMATCH_REPAIR",-0.32549,-1.16,0.208,15319,0.53,"MSH6, RFC3, MSH3, RFC2, RFC5, EXO1, MSH2, RFC1, RPA2",0.681936665037238,0.275724130399211,FALSE +"Coldren et al","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.35512,1.02,0.409,6050,0.795,"PIK3R2, VEGFB, MAPK3, RPS6KB2, PIK3CA, TSC1, CAB39, RICTOR, BRAF, PRKAA1, PGF, VEGFA, PIK3R3, HIF1A, RPS6KA2, DDIT4, VEGFC, RHEB, MAPK1, RPS6KA1, PIK3R5, PIK3CB, ULK1",0.388276691992658,0.0996328713435297,FALSE +"Coldren et al","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.2602,0.76,0.835,6624,0.98,"ITGB2, VAV1, PIK3R2, PLCG2, RAC2, VAV3, RAET1L, MAPK3, PTPN6, VAV2, IFNB1, PIK3CA, SH3BP2, PTK2B, TNFSF10, BRAF, PLCG1, CHP1, PPP3CA, LCK, CSF2, PIK3R3, ULBP2, RAC1, IFNGR1, PAK1, BID, MAPK1, NFATC1, PIK3R5, PIK3CB, SYK, NFATC4, HCST, GRB2, CHP2",0.0783135245163979,0.00877392430750515,FALSE +"Coldren et al","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.21335,0.627,0.962,5100,0.987,"DRD5, P2RY2, VIPR2, PTAFR, BDKRB2, P2RY6, P2RX4, LPAR2, VIPR1, S1PR4, THRB, GRIN1, NPBWR1, ADORA1, ADORA2B, ADORA2A, GIPR, S1PR2, GALR3, CGA, BDKRB1, GHSR, GABRP, F2RL3, GRIN2A, OPRL1, CHRNB4, MLNR, S1PR5, ADRB2, GRIN2D, P2RX6, EDNRA, F2RL1, MC3R, P2RX2, LTB4R2, HTR7, CHRNB1, ADRA2A, GRIN3B, GRM4, LTB4R, PRLR, ADRA2B, GH2",0.0168249279621871,0.00568284733036327,FALSE +"Coldren et al","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.33316,0.964,0.501,5975,0.882,"GAB1, NTF4, PRKCD, TRAF6, MAPK13, PIK3R2, PLCG2, FOXO3, CALML3, ARHGDIB, IKBKB, CAMK2G, MAPK3, MAP3K1, SH2B2, PIK3CA, NTRK2, RAP1A, IRS2, TP73, BRAF, PLCG1, YWHAB, RELA, MAPK11, NGFR, IRAK4, BAD, YWHAZ, MAP3K5, PIK3R3, YWHAH, RPS6KA2, SORT1, CALML6, RPS6KA4, MAPKAPK2, CRKL, NGF, RAC1, BAX, MAPK1, MAP2K7, RPS6KA1, MAPK10, PIK3R5, IRS1, PIK3CB, NFKBIA",0.300162274132754,0.0545314148681803,FALSE +"Coldren et al","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.264,0.764,0.85,4274,0.997,"QPRT, NMRK1, NADSYN1, NADK, NT5C1B",0.0705810742857073,0.00130484168834428,FALSE +"Coldren et al","Log2FC","KEGG_NITROGEN_METABOLISM",0.31831,0.916,0.617,2116,0.941,"GLUL, HAL, GLS2, CA9",0.209714835966758,0.0264103765727431,FALSE +"Coldren et al","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.34339,1,0.462,4477,0.835,"CASP1, TRAF6, MAPK13, TAB3, IKBKB, MAPK3, TRIP6, CCL5, IL18, PYCARD, TAB1, RELA, CARD6, MAPK11, IL6, NOD1, NOD2, PSTPIP1, NLRP1",0.335358024443874,0.0783135245163979,FALSE +"Coldren et al","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.55072,-1.94,0.01,17605,0.437,"RAD50, PRKDC, NHEJ1, XRCC5",2,0.359518563029578,FALSE +"Coldren et al","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.34338,0.984,0.482,3686,0.863,"ERBB2, RXRA, PIK3R2, PLCG2, FOXO3, MAPK3, PIK3CA, RASSF5, RXRB, EGFR, E2F1, BRAF, PLCG1, TGFA",0.31695296176115,0.0639892042847904,FALSE +"Coldren et al","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.39588,1.13,0.278,5482,0.707,"DTX4, HES1, DVL3, DTX3L, JAG1, DTX2, RFNG, EP300, DLL1, LFNG, NOTCH3, APH1A, MFNG, DVL2, JAG2, NUMB, NOTCH1, KAT2A, HES5",0.555955204081924,0.150580586203101,FALSE +"Coldren et al","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.30853,-1.02,0.344,15978,0.705,"RFC2, XPC, RFC5, GTF2H1, XPA, GTF2H3, ERCC3, CUL4A, ERCC8, CCNH, ERCC1, POLE3, RFC1, RPA2, GTF2H2",0.46344155742847,0.151810883008601,FALSE +"Coldren et al","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.39086,1.12,0.267,3600,0.712,"MAN1B1, RPN2, ALG12, ALG3, DPM1, MOGS, MGAT4A, MGAT1, B4GALT1, MGAT5B, STT3A, ALG2, B4GALT2",0.573488738635425,0.147520006363144,FALSE +"Coldren et al","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",0.24959,0.715,0.895,7709,1,"OR4C6, OR10H2, OR2J3, OR11H4, OR8A1, OR2A12, OR2D3, GUCY2D, CALML3, OR8B8, CAMK2G, CLCA2, OR1G1, OR2A7, OR13H1, OR1I1, OR13D1, CNGB1, OR1F1, OR8G5, OR8G1, OR10A3, OR1M1, OR6Q1, OR1K1, OR5P2, OR10H1, OR10A4, OR4D2, OR2A2, CNGA4, OR52B4, CALML6, OR2D2, OR2B2, OR1J1, OR6B1, PRKACA, OR2A14, GUCA1B, OR52K1, OR9A2, OR10A6, OR4L1, OR10AD1, OR2S2, OR10S1, OR10A2, OR2A5, OR10K2, OR10A5, OR8S1, OR4X2, OR5P3, ADCY3, OR6C70, OR8D2, OR8B4, OR2L2, CAMK2D, OR10G3, PRKG2, OR4K1, PRKACG, GRK3, OR8D1, OR52I1, OR6A2",0.048176964684088,0,FALSE +"Coldren et al","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.44426,-1.59,0.0263,14974,0.298,"DHFR, SHMT2, MTHFS, MTR, MTHFD2L, GART, MTHFD2, MTHFD1L, TYMS, ATIC",1.58004425151024,0.525783735923745,FALSE +"Coldren et al","Log2FC","KEGG_OOCYTE_MEIOSIS",-0.25168,-0.884,0.57,15742,0.907,"ITPR2, PPP2R5D, PPP3CC, ADCY7, PPP2R5C, PRKX, RPS6KA3, PTTG2, PPP2CB, PPP2R1B, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, ITPR1, ANAPC10, FBXO5, CDC20, PRKACB, PPP3R1, CDK1, SMC1A, CALM2, CCNB1, FBXO43, CPEB1, AR, PTTG1, YWHAQ, SGO1, SMC3, IGF1, PPP1CC, ANAPC13",0.244125144327509,0.0423927129399047,FALSE +"Coldren et al","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",0.61199,1.77,0.0123,5940,0.351,"MANBA, NEU1, ENGASE, MAN2B2, MAN2C1, GLB1, FUCA1, HEXB, MAN2B1, GBA, HEXA, AGA",1.9100948885606,0.454692883534176,FALSE +"Coldren et al","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",0.23049,0.67,0.923,6376,0.986,"NDUFV1, LHPP, ATP6V1C2, COX5B, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP5F1E, NDUFB7, NDUFS8, NDUFA3, NDUFV2, ATP6AP1, COX6C, UQCR10, COX6B2, SDHD, UQCR11, TCIRG1, NDUFB4, NDUFAB1, ATP6V1G1, UQCRB, ATP6V0A4, NDUFA6, UQCRHL, NDUFA5, UQCRC1, NDUFB5, COX15, ATP5MG, UQCRFS1, ATP6V1C1, UQCRC2, COX6A1, ATP6V1E1, NDUFA2, COX17, ATP5PD",0.0347982989740879,0.0061230850587888,FALSE +"Coldren et al","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.49419,1.43,0.0514,4056,0.61,"GALNT12, GALNT3, GALNT7, GALNT6, B4GALT5, GCNT1, ST6GALNAC1, GCNT3, C1GALT1, GALNT15, ST3GAL1, GALNT11, GALNT9, B3GNT6",1.28903688100472,0.214670164989233,FALSE +"Coldren et al","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.1914,0.551,0.988,5981,0.999,"TP53AIP1, CCNG2, CD82, SERPINB5, SFN, THBS1, TP73, ATR, PERP, SHISA5, EI24, GADD45B, ZMAT3, CCNE1, SIAH1, PIDD1, BID, IGFBP3, BAX, CHEK2, GADD45A, PTEN",0.00524305541237188,0.000434511774017692,FALSE +"Coldren et al","Log2FC","KEGG_PANCREATIC_CANCER",0.34675,0.996,0.452,5894,0.837,"ERBB2, PLD1, PIK3R2, RALB, RAC2, VEGFB, IKBKB, MAPK3, RALGDS, PIK3CA, EGFR, E2F1, RALBP1, STAT3, BRAF, RELA, TGFA, BAD, PGF, VEGFA, PIK3R3, STAT1, TGFB3, RALA, VEGFC, RAC1, JAK1, TGFBR2, MAPK1, MAPK10, PIK3R5, PIK3CB",0.344861565188618,0.07727454200674,FALSE +"Coldren et al","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.31788,0.93,0.561,8542,0.943,"PANK2, PPCS, ENPP1, COASY, UPB1, PPCDC, BCAT2, DPYD, VNN2",0.251037138743839,0.0254883072626717,FALSE +"Coldren et al","Log2FC","KEGG_PARKINSONS_DISEASE",-0.18037,-0.639,0.966,17631,1,"UBE2J2, ATP5F1C, NDUFA9, VDAC2, LRRK2, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, UCHL1, ATP5F1A, SLC18A2, PARK7, NDUFS5",0.0150228735845067,0,FALSE +"Coldren et al","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.30571,-1.05,0.38,18248,0.704,"YWHAQ, TUBA1A, NCL, ROCK2, TUBB4A, ARHGEF2, TUBB2B, TUBB2A",0.42021640338319,0.152427340857888,FALSE +"Coldren et al","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.2849,0.834,0.737,5981,1,"WNT3A, WNT9A, CBLC, CSF1R, WNT7B, CDH1, ERBB2, FZD10, LAMA3, TRAF6, FGF11, MMP9, RXRA, BCR, FGFR2, TRAF4, PLD1, PDGFA, PIK3R2, PLCG2, RALB, LAMB3, EGLN3, WNT7A, RAC2, WNT4, VEGFB, LAMC2, DVL3, IKBKB, MAPK3, RALGDS, PML, PDGFB, RARA, BMP2, FLT3LG, PIK3CA, JUP, RASSF5, WNT10A, FADD, RXRB, MET, IGF1R, FGF1, MAX, ITGA3, EP300, EGFR, GLI3, STAT5B, E2F1, DAPK1, RALBP1, FGFR3, ITGA2B, PPARG, CBLB, ARNT2, STAT3, BRAF, PLCG1, CDKN1B, RELA, TCF7L1, FZD4, TGFA, FOXO1, IL6, DVL2, MECOM, LAMA5, WNT11, RUNX1, BAD, PGF, PIAS3, LAMB1, EPAS1, ITGA2, VEGFA, FGF12, DAPK2, PIK3R3, HIF1A, STAT1, CCNA1, CCNE1, STK4, TGFB3, CRKL, PTCH1, RALA, MITF, SLC2A1, STAT5A, VEGFC, RAC1, JAK1, BID, TGFBR2, BAX, MAPK1, WNT5A, MAPK10, PIK3R5, TFG, PIK3CB, CEBPA, NFKBIA, PTEN",0.132532512140949,0,FALSE +"Coldren et al","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.47895,1.37,0.0867,4741,0.734,"DHDH, UGT2B17, GUSB, RPEL1, DCXR",1.06198090252379,0.134303940083929,FALSE +"Coldren et al","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.43515,1.26,0.141,5085,0.763,"PGLS, ALDOC, FBP1, PGM1, PFKL, FBP2, ALDOA, H6PD, G6PD, RPEL1, RBKS, DERA, PGM2",0.85078088734462,0.11747546204512,FALSE +"Coldren et al","Log2FC","KEGG_PEROXISOME",0.42548,1.23,0.18,5270,0.704,"CAT, ACOT8, GSTK1, PRDX5, PEX11A, XDH, PXMP4, ACAA1, MVK, AGXT, PEX11G, PEX2, HMGCL, EPHX2, PAOX, IDH2, ACSL1, EHHADH, PEX11B, CROT, ABCD1, ACOX1, ACSL3, PEX10, PEX13, PEX26, SCP2, PEX7, MLYCD, SLC25A17, ABCD4, PEX1, ACSL5, ACSL6",0.744727494896694,0.152427340857888,FALSE +"Coldren et al","Log2FC","KEGG_PHENYLALANINE_METABOLISM",0.40531,1.17,0.212,5148,0.738,"ALDH3B2, ALDH1A3, ALDH3B1, AOC2, NAA80, IL4I1, TAT, MAOA, MIF",0.673664139071249,0.131943638176958,FALSE +"Coldren et al","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.30436,0.891,0.643,6064,0.959,"CDS1, DGKA, PIK3R2, PLCG2, INPP4B, PLCD1, CALML3, INPP4A, PIK3CA, PIP4K2C, CDS2, PLCG1, PIK3C2G, PIK3C2B, DGKH, INPP5K, IMPA2, PIK3R3, PIP5K1C, CALML6, DGKI, ITPR3, INPPL1, INPP5J, PIK3R5, PIK3CB, DGKE, PTEN, PLCB3",0.191789027075778,0.0181813928293364,FALSE +"Coldren et al","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.31034,0.894,0.627,4098,0.961,"ALAD, CP, HMOX2, FTH1, UGT2B17, MMAB, GUSB, HMBS",0.202732459169284,0.0172766123314547,FALSE +"Coldren et al","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.41424,1.21,0.178,5270,0.675,"RXRA, ACAA1, CPT1B, PPARA, PLIN1, CYP4A22, FABP6, ACSL1, RXRB, CPT2, CPT1C, EHHADH, SLC27A6, PLTP, SLC27A1, PPARG, ACOX1, ACSL3, SCD5, SLC27A4, SCP2, OLR1, ACSL5, ACSL6",0.749579997691106,0.170696227168975,FALSE +"Coldren et al","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.20209,-0.707,0.941,14148,1,"ACOX2, HSD17B4, CYP7A1, HSD3B7, AKR1C4, CYP39A1, BAAT",0.0264103765727431,0,FALSE +"Coldren et al","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",0.5701,1.65,0.0112,4719,0.336,"RFXANK, BLNK, RAG1, JAK3, CD40, ADA, CD79A, RAG2, CD19, IL7R, CIITA, LCK, CD4",1.95078197732982,0.473660722610156,FALSE +"Coldren et al","Log2FC","KEGG_PRION_DISEASES",0.24524,0.708,0.915,5622,0.994,"MAPK3, CCL5, IL6, NOTCH1, PRKACA, IL1A, C9, BAX, MAPK1, EGR1",0.0385789059335517,0.00261361560268669,FALSE +"Coldren et al","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28022,-0.975,0.418,15860,0.788,"ADCY7, PRKX, RPS6KA3, CCNA2, AKT3, MAD2L2, BUB1, CDC25C, CDC23, PIK3R1, GNAI1, PIK3CG, CCNB2, ANAPC10, PRKACB, CDK1, CCNB3, CDC25A, CCNB1, MAPK8, CPEB1, IGF1, HSP90AB1, HSP90AA1, ANAPC13, PDE3A, PDE3B",0.378823718224965,0.103473782510445,FALSE +"Coldren et al","Log2FC","KEGG_PROPANOATE_METABOLISM",0.35657,1.04,0.389,3581,0.766,"LDHC, ACSS2, ALDH6A1, ABAT, MCEE, EHHADH, PCCB, ACSS1",0.410050398674292,0.115771230367396,FALSE +"Coldren et al","Log2FC","KEGG_PROSTATE_CANCER",0.26783,0.77,0.841,6422,1,"ERBB2, FGFR2, PDGFA, PIK3R2, IKBKB, MAPK3, PDGFB, PIK3CA, IGF1R, PDGFD, EP300, EGFR, E2F1, BRAF, CDKN1B, RELA, TCF7L1, CREB3L4, TGFA, FOXO1, BAD, PIK3R3, CCNE1, CREB3L3, CREB3L2, MAPK1, CREB5, CREB3L1, PIK3R5, PIK3CB, NFKBIA, PTEN, GSK3B, CDKN1A, CREB3",0.0752040042020878,0,FALSE +"Coldren et al","Log2FC","KEGG_PROTEASOME",-0.31612,-1.17,0.226,15132,0.543,"PSMB5, PSMD4, PSMD6, PSMC5, PSMB4, PSMA6, PSMD7, PSMC1, PSMC6, PSMD1, PSMC4, PSMB7, PSMA4, PSMA1, PSMD8, PSMB1, POMP, PSMD14",0.645891560852599,0.265200170411153,FALSE +"Coldren et al","Log2FC","KEGG_PROTEIN_EXPORT",-0.31244,-1.07,0.309,16054,0.69,"SEC61A2, SEC11A, SRPRB, SRP72, SRP9, SRP19, SEC11C, SEC63",0.510041520575165,0.161150909262745,FALSE +"Coldren et al","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.19349,0.56,0.993,8289,1,"GLS2, SLC9A3, SLC25A10, MDH1, SLC4A4, GLUD1, ATP1A2, AQP1, ATP1A1",0.00305075150461883,0,FALSE +"Coldren et al","Log2FC","KEGG_PURINE_METABOLISM",-0.30249,-1.04,0.368,15717,0.692,"PNPT1, PRPS1, RRM2, ADCY7, PFAS, POLR3B, ENTPD8, POLR2L, RRM2B, PAICS, ADSL, APRT, GART, NPR2, RRM1, PDE6B, PNP, PRIM1, NME1, PDE6C, POLR3G, PDE8A, POLR3A, AK5, NME7, PPAT, PDE11A, PRIM2, POLE3, POLR2E, POLR3C, PDE1A, ATIC, ENTPD1, PDE4B, PDE4D, POLR2D, POLR1E, PDE3A, PDE3B, POLA1, PDE10A, PDE7B, PDE8B",0.434152181326482,0.159893905543242,FALSE +"Coldren et al","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.25943,-0.912,0.557,14988,0.897,"DHODH, POLE, NT5E, NME2, UPP2, CAD, POLR2C, POLR3K, PNPT1, RRM2, POLR3B, ENTPD8, POLR2L, RRM2B, AK3, TXNRD1, DTYMK, RRM1, PNP, PRIM1, NME1, TYMS, POLR3G, POLR3A, NME7, PRIM2, POLE3, POLR2E, POLR3C, ENTPD1, POLR2D, POLR1E, UCK2, POLA1, CTPS1",0.254144804826271,0.0472075569559079,FALSE +"Coldren et al","Log2FC","KEGG_PYRUVATE_METABOLISM",0.22031,0.64,0.956,1378,0.986,"LDHC, ACSS2, PC",0.0195421077238999,0.0061230850587888,FALSE +"Coldren et al","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.28027,0.812,0.779,5612,1,"PAK6, SSH3, BDKRB2, MYH14, BAIAP2, FGF11, ITGB2, VAV1, FGFR2, ITGB6, PDGFA, PIK3R2, ITGB8, RAC2, VAV3, LIMK2, FGD3, ITGB4, ARHGEF4, MAPK3, PPP1CA, VAV2, GSN, PDGFB, PFN4, PIK3CA, PPP1CB, PIP4K2C, BDKRB1, FGF1, SSH2, PDGFD, ITGA3, EGFR, FGFR3, ITGA2B, BRAF, TIAM1, PXN, MYL9, TIAM2, ARHGAP35, PAK2, SLC9A1, ITGA2, WASL, FGF12, PIK3R3, PIP5K1C, LIMK1, CRKL, ARHGEF7, SCIN, MYL7, RAC1, IQGAP1, PAK1, RRAS, BCAR1, ITGAX, PAK4, MAPK1",0.108462542327436,0,FALSE +"Coldren et al","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.20206,-0.716,0.901,18035,1,"PIK3C3, PRKAA2, IFNA13",0.045275209020937,0,FALSE +"Coldren et al","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.3643,1.07,0.323,5894,0.748,"GAB1, PAK6, PIK3R2, EGLN3, VEGFB, MAPK3, PDGFB, PIK3CA, MET, EP300, RAP1A, ARNT2, BRAF, TGFA, PAK2, PGF, EPAS1, VEGFA, PIK3R3, HIF1A, TGFB3, CRKL, FLCN, SLC2A1, VEGFC, RAC1, PAK1, PAK4, MAPK1, PIK3R5, PIK3CB",0.490797477668897,0.126098402135539,FALSE +"Coldren et al","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.39819,1.15,0.231,4025,0.71,"CTSA, ACE2, ACE, ANPEP",0.636388020107856,0.148741651280925,FALSE +"Coldren et al","Log2FC","KEGG_RETINOL_METABOLISM",0.43832,1.28,0.133,5807,0.746,"ADH7, RDH16, CYP26B1, DHRS9, DHRS3, DGAT1, CYP4A22, CYP26A1, UGT2B17, CYP1A1, RDH10, RDH11, LRAT, CYP26C1, CYP2C9, CYP2A7, ALDH1A2, AWAT2, CYP2C8",0.876148359032914,0.127261172527331,FALSE +"Coldren et al","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",0.28656,0.826,0.712,3165,1,"ACP6, ACP5, MTMR1",0.147520006363144,0,FALSE +"Coldren et al","Log2FC","KEGG_RIBOSOME",-0.37924,-1.29,0.19,14672,0.511,"RPL22L1, RPS23, RPL26, RPL21, RPL13A, RPS24, RPL10A, RPL37A, RPS11, RPS27A, RPL35, RPL10, RPL26L1, RPL34, RPL27A, RPLP0, RPL11, RPL32, RPS8, RPL18, RPS27, RPL9, RPS20, RPS10, RPS6, RPL4, RPL5, RPL14, RPSA, RPS13, RPS7, RPS19, RSL24D1, RPS12, RPL6, RPS4Y1, RPS16, RPL17",0.721246399047171,0.291579099865287,FALSE +"Coldren et al","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.42041,1.22,0.156,3761,0.678,"TRADD, TRAF6, DHX58, MAPK13, MAVS, IRF3, CXCL10, IKBKB, IFNB1, MAP3K1, TKFC, FADD, ISG15, IFIH1, DDX58, NLRX1, IL12B, CASP10, RELA, MAPK11, IKBKE",0.806875401645538,0.168770306132937,FALSE +"Coldren et al","Log2FC","KEGG_RNA_DEGRADATION",-0.39068,-1.33,0.115,15014,0.479,"CNOT7, LSM2, EXOSC6, LSM1, LSM5, CNOT1, PNPT1, DCP1A, LSM7, EDC4, LSM3, EXOSC9, CNOT10, EXOSC5, EXOSC3, PAPOLA, TTC37, ZCCHC7, EXOSC10, MTREX, ENO1, DCP2, CNOT9, ENO3, EXOSC8, HSPA9, DCP1B, HSPD1",0.939302159646388,0.319664486585437,FALSE +"Coldren et al","Log2FC","KEGG_RNA_POLYMERASE",-0.36582,-1.24,0.233,17492,0.48,"POLR3G, POLR3A, POLR2E, POLR3C, POLR2D, POLR1E",0.632644078973981,0.318758762624413,FALSE +"Coldren et al","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",-0.20795,-0.68,0.943,17399,1,"SCLY, MAT2A, MARS2, SEPHS1, TRMT11",0.0254883072626717,0,FALSE +"Coldren et al","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.2741,0.799,0.815,4622,0.995,"LAMA3, TRAF6, RXRA, TRAF4, PIK3R2, LAMB3, LAMC2, IKBKB, PIK3CA, RXRB, MAX, ITGA3, E2F1, ITGA2B, CDKN1B, RELA, LAMA5, PIAS3, LAMB1, ITGA2, PIK3R3",0.0888423912600234,0.00217691925427455,FALSE +"Coldren et al","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.44073,1.28,0.138,4358,0.746,"SNAP23, STX16, STX10, VAMP8, STX19, YKT6, STX17, VTI1B, TSNARE1, STX3, GOSR2, SNAP29, BET1, USE1, STX5, BET1L",0.860120913598763,0.127261172527331,FALSE +"Coldren et al","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",0.24714,0.726,0.897,8272,1,"ARSA, SPTLC2, NEU1, ASAH1, PLPP3, DEGS2, SPHK2, GLB1, SPHK1, GBA, SGMS2, SGPP1, SPTLC1, ENPP7, UGCG, SMPD3, SMPD2, SGPP2, NEU2, SMPD1, UGT8",0.0472075569559079,0,FALSE +"Coldren et al","Log2FC","KEGG_SPLICEOSOME",-0.28279,-0.974,0.491,14820,0.756,"HSPA1A, SNRNP27, DDX23, LSM2, SF3A3, SF3B1, SNRPB, SNRPF, PRPF8, BCAS2, LSM5, PRPF3, THOC1, SRSF3, SF3A2, DDX39B, EIF4A3, LSM7, SF3B4, TCERG1, RBM22, U2AF1, LSM3, SNRNP40, SYF2, DDX5, HNRNPK, DHX15, HNRNPA1L2, BUD31, PQBP1, PRPF40A, THOC2, PRPF4, SNRPA1, RBM8A, ALYREF, CDC5L, RBM17, SRSF7, SNRPE, PRPF18, SNRPD2, CDC40, SNRPC, RBMX, SRSF1, HNRNPA3, HSPA8, HNRNPM, HNRNPA1, HNRNPC, SF3B5, MAGOHB, PPIH, HNRNPU, PPIE, TXNL4A, SRSF10",0.308918507877032,0.121478204498793,FALSE +"Coldren et al","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.44369,1.29,0.117,7075,0.806,"HK2, GYS1, GCK, GAA, PGM1, GANC, UGT2B17, GUSB, HK1, UXS1, PYGL, PGM2, ENPP1, MGAM, PYGB, AMY1A, UGP2, AGL",0.931814138253838,0.0936649581949093,FALSE +"Coldren et al","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.61834,1.81,0.00447,5003,0.376,"MSMO1, DHCR24, LIPA, SC5D, SQLE, FDFT1, HSD17B7, CEL, NSDHL, DHCR7, LSS, TM7SF2",2.34969247686806,0.424812155072339,FALSE +"Coldren et al","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38862,1.13,0.265,4669,0.707,"CYP11B1, CYP1B1, SULT2B1, SRD5A1, COMT, SRD5A3, CYP7B1, UGT2B17, HSD17B7, SULT1E1, CYP1A1, HSD17B8",0.576754126063192,0.150580586203101,FALSE +"Coldren et al","Log2FC","KEGG_SULFUR_METABOLISM",0.55174,1.58,0.0274,5093,0.399,"SULT2B1, CHST12, SULT1A2, SUOX, SULT1A4, CHST11, SULT1E1, SULT1A3",1.56224943717961,0.399027104313252,FALSE +"Coldren et al","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.21402,-0.75,0.783,18576,1,"SSB, GRIN2B",0.106238237942057,0,FALSE +"Coldren et al","Log2FC","KEGG_TASTE_TRANSDUCTION",0.22218,0.65,0.948,6205,0.993,"KCNB1, SCNN1A, ADCY4, TAS2R1, SCNN1G, TAS1R3, ADCY6, GNAS, TAS2R3, GRM4, TAS2R31, SCNN1B, ITPR3, PRKACA, TAS2R4, TAS2R38, TAS2R5",0.0231916626619338,0.00305075150461883,FALSE +"Coldren et al","Log2FC","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.24456,0.721,0.896,3450,1,"GGT7, GGT6",0.0476919903378748,0,FALSE +"Coldren et al","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.41775,1.22,0.158,5412,0.678,"MVK, HMGCS1, MVD, DHDDS, HMGCR",0.801342913045577,0.168770306132937,FALSE +"Coldren et al","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.21463,-0.731,0.826,15652,1,"SMAD7, TFDP1, RHOA, BMPR2, SMAD5, PITX2, BMP8B, PPP2CB, PPP2R1B, ID3, SMAD4, SKP1, SMURF2, BMPR1A, INHBE, SMAD9, BMP8A, ID2, TGFB1, CDKN2B, E2F5, ROCK2, BMP6, SMAD2",0.0830199526796178,0,FALSE +"Coldren et al","Log2FC","KEGG_THYROID_CANCER",0.39121,1.13,0.275,3392,0.707,"CDH1, RXRA, MAPK3, RXRB, PPARG, BRAF, TCF7L1",0.560667306169737,0.150580586203101,FALSE +"Coldren et al","Log2FC","KEGG_TIGHT_JUNCTION",0.33254,0.963,0.523,4350,0.875,"EPB41L1, PRKCD, AMOTL1, MYH14, CLDN8, CGN, CLDN9, CLDN7, CLDN4, F11R, TJP3, CRB3, TJP2, PRKCH, LLGL2, CLDN18, PRKCI, PARD6B, PATJ, CLDN11, CTTN, EXOC4, CLDN23, CLDN3, SRC, MYH15, MYL9, EXOC3, MAGI1, PRKCZ, OCLN",0.281498311132726,0.0579919469776868,FALSE +"Coldren et al","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.43206,1.27,0.12,6260,0.755,"TLR5, TRAF6, MAPK13, PIK3R2, IRF5, LBP, IRF3, TOLLIP, CXCL10, IKBKB, MAPK3, TLR3, IFNB1, PIK3CA, MYD88, FADD, CXCL11, CCL5, CD40, IL12B, CXCL9, TAB1, RELA, TLR1, MAPK11, IKBKE, IL6, TLR2, MAP3K8, IRAK4, TIRAP, TICAM1, PIK3R3, STAT1, IL12A, RAC1, TAB2, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB, NFKBIA, FOS, IRF7",0.920818753952375,0.122053048370812,FALSE +"Coldren et al","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",0.25994,0.746,0.859,5698,0.992,"CAT, CYP1B1, GCDH, KMO, EHHADH, IL4I1, CYP1A1, MAOA, IDO1, HAAO, OGDHL",0.0660068361687577,0.00348832784582135,FALSE +"Coldren et al","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",0.35999,1.05,0.348,1965,0.767,"PRKCD, HK2, PIK3R2, CACNA1D, SOCS1, GCK, IKBKB, MAPK3, INSR, PIK3CA",0.458420756053419,0.115204636051019,FALSE +"Coldren et al","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",-0.22684,-0.827,0.773,16990,1,"PRF1, PTPRN, HSPD1",0.111820506081675,0,FALSE +"Coldren et al","Log2FC","KEGG_TYROSINE_METABOLISM",0.48583,1.41,0.0615,2773,0.632,"ADH7, ALDH3B2, HEMK1, TH, ALDH1A3, ALDH3B1, COMT, AOC2, GSTZ1, NAA80, LCMT1",1.21112488422458,0.199282921717615,FALSE +"Coldren et al","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.29483,0.851,0.699,6624,0.99,"PAK6, CBLC, VAV1, MAPK13, PIK3R2, VAV3, DLG1, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, NCK2, CBLB, PLCG1, RELA, CHP1, MAPK11, PPP3CA, PAK2, LCK, MAP3K8, CSF2, PIK3R3, CD4, NCK1, PAK1, PAK4, MAPK1, MAP2K7, NFATC1, PIK3R5, PIK3CB, NFKBIA, GSK3B, FOS, NFATC4, GRB2, CHP2",0.155522824254319,0.00436480540245009,FALSE +"Coldren et al","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29203,0.849,0.695,6099,0.986,"CBLC, UBOX5, ITCH, UBA7, TRAF6, UBE2H, PPIL2, SOCS1, FBXO2, SMURF1, PML, MAP3K1, FBXW7, UBE2L6, RHOBTB2, HERC1, HERC3, ANAPC2, CUL7, UBE2D4, CBLB, FBXO4, RNF7, MID1, SYVN1, UBA6, FBXW8, UBR5, UBE2C, PIAS3, KLHL13, UBE3B, UBE2W, HUWE1, NEDD4L, UBE2F, TRIM32, UBE2Q1, WWP2, DDB1, SIAH1, FZR1, UBE4A, UBE2E1, UBE3C, DET1, UBE2O, UBE2E2, STUB1, UBA3, ANAPC11, UBE2M, UBE2Z",0.158015195409886,0.0061230850587888,FALSE +"Coldren et al","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.54815,-1.85,0.0204,13596,0.202,"VARS2, LARS2, BCAT1, PDHA1, IARS2",1.6903698325741,0.694648630553376,TRUE +"Coldren et al","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.42231,1.25,0.157,3822,0.723,"MCCC1, ACAA1, HIBADH, ACAD8, ALDH6A1, ABAT, HMGCL, HMGCS1, MCEE, ACADS, EHHADH, PCCB, IL4I1, AUH",0.804100347590766,0.140861702705469,FALSE +"Coldren et al","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.28813,0.834,0.724,4348,1,"PRKCD, PLA2G12A, KCNMB3, CACNA1D, PLA2G6, CALML3, PLA2G4B, ADORA2B, MAPK3, ADORA2A, PPP1CA, PRKCH, ADCY5, CYP4A22, PPP1CB, ADCY4, PLA2G10, PLA2G4E, BRAF, ADCY6, MYL9, PLA2G2C, EDNRA, KCNMB4, GNAS, GNAQ",0.140261433802853,0,FALSE +"Coldren et al","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.27394,0.8,0.79,7785,1,"DYNLL2, AQP3, RAB5B, ARHGDIB, ADCY6, CREB3L4, GNAS, DYNC2LI1, DCTN5, CREB3L3, PRKACA, CREB3L2, RAB11B, RAB5C, CREB5, CREB3L1, CREB3, ADCY9, ADCY3, NSF, CREB1, RAB11A, PRKACG, DCTN1",0.102372908709559,0,FALSE +"Coldren et al","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.37587,1.1,0.288,5894,0.725,"PLA2G12A, MAPK13, PIK3R2, PLCG2, RAC2, PLA2G6, PLA2G4B, NOS3, HSPB1, MAPK3, PIK3CA, PLA2G10, PLA2G4E, MAPKAPK3, PLCG1, SPHK2, PXN, SRC, CHP1, MAPK11, PPP3CA, PLA2G2C, BAD, VEGFA, PIK3R3, SPHK1, MAPKAPK2, RAC1, MAPK1, NFATC1, PIK3R5, PIK3CB",0.540607512240769,0.139661993429006,FALSE +"Coldren et al","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",0.35881,1.04,0.371,7679,0.766,"ERO1A, PLCG2, ATP6V1C2, TJP2, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP6AP1, KDELR3, PLCG1, PDIA4, GNAS, TCIRG1, KCNQ1, ATP6V1G1, SEC61G, ATP6V0A4, PRKACA, KDELR2, ATP6V1C1, TJP1, ATP6V1E1, ADCY9, ADCY3, SEC61B, ATP6V0C, PRKACG, ATP6V1E2, ATP6V0E2",0.430626090384954,0.115771230367396,FALSE +"Coldren et al","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.26233,0.766,0.839,3633,1,"MYH14, ITGB2, RAC2, DAG1, CD40, EIF4G1, CAV1, MYH15",0.0762380391712997,0,FALSE +"Coldren et al","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.25146,0.728,0.866,2541,1,"WNT3A, WNT9A, TBL1XR1, WNT7B, DAAM1, FZD10, PORCN, WNT7A, RAC2, SENP2, WNT4, FRAT1, CTNNBIP1, DVL3, CAMK2G, FRAT2, CSNK1E, WNT10A, LRP5, CSNK1A1, EP300, VANGL2",0.0624821079826534,0,FALSE diff --git a/Examples/Fig2/GSEA/GSEA_venn_diagram.pdf b/Examples/Fig2/GSEA/GSEA_venn_diagram.pdf new file mode 100644 index 0000000000000000000000000000000000000000..afc6ae0bc06303f53bbad3e6aeafa39266f71f85 GIT binary patch literal 6442 zcmZ{p2{hF2_s2zuimWw=u~V4EjHSksUA8PC`!oilF~gY2zD3BEHcLXX*H;oHS<7A+ zTSBsz?Ae9#|BSx%-TuEh=Q;B{_jB*_+~>|Yb6)TJ5kIG;BMXy5u!@I`hfRc0!+PvU ztS~SXOuXpMibAnMG)Y)A8Al{&p~+aVl-4OY6fO^g!VWc zAj%A^OG10P;V|A{6AIarLI%Rlk%-O|43W>r;X#S)xpS-^j1 z1BO`md1Ap3O*9#eC%S?m=g_WLZ?HVzUaV=?>8(63D>P8?3Y! z4l%=e6DcGNupi=I`_UYJmBSEAa3#Be;cz4p4AH^i$-oUDI(VQsT38Ix8B5FCn+(*< 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+
+
+ + + + diff --git a/Examples/Fig3/DMEA/DMEA_mean_results.csv b/Examples/Fig3/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..86ab748 --- /dev/null +++ b/Examples/Fig3/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"MDM inhibitor",1.86666666666667,0.265015722804013,0.000475898353953111,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, metabolomics",0.012849255556734 +"HMGCR inhibitor",1.82,0.252388589282479,1.52209119223203e-05,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, proteomics",0.00123289386570794 +"PLK inhibitor",1.62666666666667,0.239652526240249,0.000410344949248524,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, proteomics",0.012849255556734 +"microtubule inhibitor",1.54666666666667,0.245424801789333,0.00334884736346567,"transcriptomics, proteomics, metabolomics",3,1,"transcriptomics",0.0678141591101799 +"Aurora kinase inhibitor",1.45333333333333,0.089628864398325,0.0135858996870902,"transcriptomics, proteomics, metabolomics",3,0,"",0.176684580818349 +"tubulin polymerization inhibitor",1.43333333333333,0.243378991150291,0.0174503289697135,"transcriptomics, proteomics, metabolomics",3,0,"",0.176684580818349 +"sterol demethylase inhibitor",1.35333333333333,0.0665832811847939,0.0586291436870008,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444 +"acetylcholine receptor agonist",1.31333333333333,0.0776745346515402,0.0817710395821918,"transcriptomics, proteomics, metabolomics",3,0,"",0.287976269832936 +"protein synthesis inhibitor",1.31333333333333,0.150111069989303,0.0760879765060129,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444 +"PARP inhibitor",1.29666666666667,0.181475434517549,0.0671557019171678,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444 +"RAF inhibitor",1.28733333333333,0.518711223450325,0.0172805979005271,"transcriptomics, proteomics, metabolomics",3,0,"",0.176684580818349 +"DNA polymerase inhibitor",1.20666666666667,0.198578280114753,0.15892160326282,"transcriptomics, proteomics, metabolomics",3,0,"",0.433447304602584 +"serotonin receptor agonist",1.203,0.341214009091069,0.135379131943202,"transcriptomics, proteomics, metabolomics",3,0,"",0.421758064899977 +"topoisomerase inhibitor",1.178,0.532326967192157,0.0775610159577255,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444 +"ATPase inhibitor",1.17666666666667,0.228108161479008,0.21362467604965,"transcriptomics, proteomics, metabolomics",3,0,"",0.500845418127828 +"DNA synthesis inhibitor",1.17033333333333,0.295398600764007,0.182965639853951,"transcriptomics, proteomics, metabolomics",3,0,"",0.463131775880312 +"growth factor receptor inhibitor",1.16666666666667,0.240069434400411,0.210093890642291,"transcriptomics, proteomics, metabolomics",3,0,"",0.500845418127828 +"AP inhibitor",1.13266666666667,0.190161335011441,0.308401804743253,"transcriptomics, proteomics, metabolomics",3,0,"",0.624513654605088 +"androgen receptor antagonist",1.084,0.326827171453048,0.266823887159565,"transcriptomics, proteomics, metabolomics",3,0,"",0.584127969187156 +"DNA inhibitor",1.08366666666667,0.190500218722534,0.352669787379634,"transcriptomics, proteomics, metabolomics",3,0,"",0.6382960627833 +"serotonin receptor antagonist",1.04566666666667,0.340288603002412,0.373247133137964,"transcriptomics, proteomics, metabolomics",3,0,"",0.6382960627833 +"CC chemokine receptor antagonist",1.04066666666667,0.364117197250189,0.326759399681463,"transcriptomics, proteomics, metabolomics",3,0,"",0.630178842242821 +"opioid receptor agonist",1.02533333333333,0.306496873284759,0.416660861555529,"transcriptomics, proteomics, metabolomics",3,0,"",0.649029418961496 +"bromodomain inhibitor",1.00833333333333,0.388469217999745,0.428500966234831,"transcriptomics, proteomics, metabolomics",3,0,"",0.650446257698751 +"NFkB pathway inhibitor",1.00066666666667,0.383198816977993,0.481197439749004,"transcriptomics, proteomics, metabolomics",3,0,"",0.696017725351238 +"DNA alkylating agent",0.995,0.427287959109545,0.413736273268339,"transcriptomics, proteomics, metabolomics",3,0,"",0.649029418961496 +"sodium channel blocker",0.99,0.293087017795057,0.530258958675574,"transcriptomics, proteomics, metabolomics",3,0,"",0.715849594212025 +"JAK inhibitor",0.982666666666667,0.281569411217436,0.515549734111053,"transcriptomics, proteomics, metabolomics",3,0,"",0.707788618016869 +"adrenergic receptor antagonist",0.943666666666667,0.253653963764285,0.635559049668344,"transcriptomics, proteomics, metabolomics",3,0,"",0.804379422236497 +"proteasome inhibitor",0.933,0.317472833483434,0.55999947357726,"transcriptomics, proteomics, metabolomics",3,0,"",0.743605858356689 +"thymidylate synthase inhibitor",0.932,1.35350360176839,0.00504301077744804,"transcriptomics, proteomics, metabolomics",3,1,"transcriptomics",0.0816967745946582 +"progesterone receptor agonist",0.927,0.367990489007529,0.577506824057817,"transcriptomics, proteomics, metabolomics",3,0,"",0.754484721752954 +"CDK inhibitor",0.844,0.229338178243397,0.82757167059327,"transcriptomics, proteomics, metabolomics",3,0,"",0.957618647400784 +"bacterial DNA gyrase inhibitor",0.825333333333333,0.136030633804792,0.871854599105644,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541 +"dopamine receptor antagonist",0.791666666666667,0.206863078709888,0.90542642677809,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541 +"calcium channel blocker",0.791333333333333,0.118542538075297,0.91960259226323,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541 +"mTOR inhibitor",0.776666666666667,0.348495815374207,0.843673863270491,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541 +"benzodiazepine receptor agonist",0.773333333333333,0.391604817811698,0.803897232162772,"transcriptomics, proteomics, metabolomics",3,0,"",0.957583467723302 +"ribonucleotide reductase inhibitor",0.754,1.34708128930663,0.0447670838966327,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444 +"FLT3 inhibitor",0.714,1.26068552779827,0.0976371875375639,"transcriptomics, proteomics, metabolomics",3,0,"",0.329525507939278 +"cyclooxygenase inhibitor",0.641,0.115169440391104,0.992617654193712,"transcriptomics, proteomics, metabolomics",3,0,"",0.999803459608076 +"potassium channel blocker",0.588,1.16604116565411,0.31915113756098,"transcriptomics, proteomics, metabolomics",3,0,"",0.630178842242821 +"cytochrome P450 inhibitor",0.524,1.11214567391147,0.439817458216868,"transcriptomics, proteomics, metabolomics",3,0,"",0.650446257698751 +"antioxidant",0.502333333333333,1.22673401083256,0.304049914810119,"transcriptomics, proteomics, metabolomics",3,0,"",0.624513654605088 +"estrogen receptor antagonist",0.448,1.20522155639534,0.363876963065475,"transcriptomics, proteomics, metabolomics",3,0,"",0.6382960627833 +"phosphodiesterase inhibitor",0.433666666666667,1.17381443735087,0.441661039178165,"transcriptomics, proteomics, metabolomics",3,0,"",0.650446257698751 +"phosphatase inhibitor",0.429,1.23833073126689,0.378843242790434,"transcriptomics, proteomics, metabolomics",3,0,"",0.6382960627833 +"Bcr.Abl kinase inhibitor",0.396666666666667,1.58774473179203,0.0560128267928313,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444 +"HCV inhibitor",0.393333333333333,1.45822952011449,0.147756426724638,"transcriptomics, proteomics, metabolomics",3,0,"",0.427438234453418 +"glucocorticoid receptor agonist",0.358333333333333,0.880274010370256,0.818696675196103,"transcriptomics, proteomics, metabolomics",3,0,"",0.957618647400784 +"PDGFR tyrosine kinase receptor inhibitor",0.356666666666667,1.33087690389958,0.288989252911853,"transcriptomics, proteomics, metabolomics",3,0,"",0.616003407522634 +"KIT inhibitor",0.355,1.13449327895761,0.596152318363481,"transcriptomics, proteomics, metabolomics",3,0,"",0.766481552181618 +"PPAR receptor agonist",0.35,1.38924439894498,0.22404306515654,"transcriptomics, proteomics, metabolomics",3,0,"",0.504096896602216 +"Abl kinase inhibitor",0.349666666666667,1.38335112438359,0.160536038741698,"transcriptomics, proteomics, metabolomics",3,0,"",0.433447304602584 +"BCL inhibitor",0.336666666666667,1.62102848011173,0.0464684208790804,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444 +"FGFR inhibitor",0.3,1.58489747302467,0.102965841375668,"transcriptomics, proteomics, metabolomics",3,0,"",0.333609326057164 +"acetylcholine receptor antagonist",0.294333333333333,0.921609642600018,0.906789128471235,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541 +"bacterial 50S ribosomal subunit inhibitor",0.292333333333333,1.24249600938326,0.490803034982237,"transcriptomics, proteomics, metabolomics",3,0,"",0.697456944448443 +"histamine receptor antagonist",0.203,0.967905470591008,0.873078493466175,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541 +"glycogen synthase kinase inhibitor",0.145333333333333,0.943390339855849,0.918407696496075,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541 +"adrenergic receptor agonist",-0.19,0.620684299785326,0.999803459608076,"transcriptomics, proteomics, metabolomics",3,0,"",0.999803459608076 +"glutamate receptor antagonist",-0.200666666666667,1.2942106989719,0.337763993998668,"transcriptomics, proteomics, metabolomics",3,0,"",0.636253104974234 +"HSP inhibitor",-0.207333333333333,1.07157376476533,0.76820724450362,"transcriptomics, proteomics, metabolomics",3,0,"",0.957304412381435 +"MET inhibitor",-0.235666666666667,1.54887518326472,0.0635837147966158,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.285565558753444 +"estrogen receptor agonist",-0.246666666666667,0.902130995661569,0.924652387169855,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541 +"PI3K inhibitor",-0.249333333333333,0.811833932115019,0.970994407747962,"transcriptomics, proteomics, metabolomics",3,0,"",0.995576544652974 +"DNA methyltransferase inhibitor",-0.353333333333333,1.22414596079607,0.394009915298334,"transcriptomics, proteomics, metabolomics",3,0,"",0.6382960627833 +"p38 MAPK inhibitor",-0.404,1.63115541871399,0.0656656912525568,"transcriptomics, proteomics, metabolomics",3,1,"proteomics",0.285565558753444 +"RET tyrosine kinase inhibitor",-0.441666666666667,1.24382809637559,0.356406295822533,"transcriptomics, proteomics, metabolomics",3,0,"",0.6382960627833 +"retinoid receptor agonist",-0.444,1.36105400333712,0.216414686845358,"transcriptomics, proteomics, metabolomics",3,0,"",0.500845418127828 +"VEGFR inhibitor",-0.459666666666667,0.870545997253065,0.787248929107976,"transcriptomics, proteomics, metabolomics",3,0,"",0.957583467723302 +"ALK tyrosine kinase receptor inhibitor",-0.503,1.15683490611236,0.391697866815001,"transcriptomics, proteomics, metabolomics",3,0,"",0.6382960627833 +"TGF beta receptor inhibitor",-0.576666666666667,1.66452195339483,0.029594121219828,"transcriptomics, proteomics, metabolomics",3,1,"proteomics",0.239712381880607 +"tyrosine kinase inhibitor",-0.818,0.229540846038347,0.801612856650322,"transcriptomics, proteomics, metabolomics",3,0,"",0.957583467723302 +"protein tyrosine kinase inhibitor",-0.950666666666667,1.36255691012645,0.0204311970211077,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, proteomics",0.183880773189969 +"MEK inhibitor",-1.01133333333333,0.12901679477236,0.513081914469135,"transcriptomics, proteomics, metabolomics",3,0,"",0.707788618016869 +"HDAC inhibitor",-1.06733333333333,0.615013278989432,0.170041860108312,"transcriptomics, proteomics, metabolomics",3,0,"",0.444302924799137 +"CHK inhibitor",-1.21,0.454312667664022,0.142988393629169,"transcriptomics, proteomics, metabolomics",3,0,"",0.427438234453418 +"adenosine receptor antagonist",-1.29733333333333,0.411681106359441,0.0722321335955761,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444 +"AKT inhibitor",-1.33566666666667,0.538596633236166,0.049627452949737,"transcriptomics, proteomics, metabolomics",3,1,"transcriptomics",0.285565558753444 +"src inhibitor",-1.38,0.223383079036887,0.0585321359439333,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444 +"vitamin D receptor agonist",-2.08333333333333,0.410406302745625,NA,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, proteomics",NA +"EGFR inhibitor",-2.11333333333333,0.316596483450675,NA,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, proteomics",NA diff --git a/Examples/Fig3/DMEA/DMEA_results.csv b/Examples/Fig3/DMEA/DMEA_results.csv new file mode 100644 index 0000000..2f0becf --- /dev/null +++ b/Examples/Fig3/DMEA/DMEA_results.csv @@ -0,0 +1,250 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"transcriptomics","Pearson.est","EGFR inhibitor",-0.82471,-2.33,0,1374,0.00707,"CUDC.101, AEE788, BIBU.1361, PD.153035, TAK.285, vandetanib, BIBX.1382, rociletinib, CP.724714, pelitinib, icotinib, GW.583340, WZ8040, erlotinib, afatinib, ARRY.334543, PD.168393, dacomitinib, gefitinib, XL.647, BMS.690514, neratinib, lapatinib, osimertinib, poziotinib, AZD8931, canertinib, tucatinib",Inf,2.1505805862031,TRUE +"transcriptomics","Pearson.est","Abl kinase inhibitor",0.60551,1.46,0.0537,225,0.308,"GZD824, KW.2449, ponatinib, tozasertib, flumatinib, nilotinib",1.27002571430044,0.511449283499556,FALSE +"transcriptomics","Pearson.est","acetylcholine receptor agonist",0.58097,1.4,0.0907,502,0.302,"oxiracetam, xanomeline, pilocarpine, tremorine",1.0423927129399,0.519993057042849,FALSE +"transcriptomics","Pearson.est","acetylcholine receptor antagonist",0.30262,0.727,0.816,803,0.991,"iododexetimide, methscopolamine, darifenacin",0.0883098412461389,0.00392634551472468,FALSE +"transcriptomics","Pearson.est","adenosine receptor antagonist",-0.55714,-1.54,0.0703,1427,0.249,"MRS.1220, CGS.15943",1.15304467498018,0.603800652904264,FALSE +"transcriptomics","Pearson.est","adrenergic receptor agonist",-0.22191,-0.617,0.938,318,0.973,"buphenine, clenbuterol, oxymetazoline, midodrine, lidamidine, ritodrine, isoxsuprine, norepinephrine, isoetharine, terbutaline, metaraminol, epinephrine, A61603, methyldopa, xylazine",0.0277971616209356,0.0118871597316481,FALSE +"transcriptomics","Pearson.est","adrenergic receptor antagonist",0.44946,1.08,0.376,525,0.664,"oxprenolol, idazoxan, atipamezole, carvedilol, naftidrofuryl, vincamine, levobunolol, metoprolol",0.424812155072339,0.177831920631982,FALSE +"transcriptomics","Pearson.est","AKT inhibitor",-0.58362,-1.7,0.0408,1336,0.212,"triciribine, CCT128930, GSK2110183, uprosertib, GDC.0068",1.38933983691012,0.673664139071249,TRUE +"transcriptomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.34351,0.831,0.683,148,0.91,"DMH1, AZD3463",0.165579296318467,0.0409586076789064,FALSE +"transcriptomics","Pearson.est","androgen receptor antagonist",0.60467,1.46,0.063,480,0.308,"nilutamide, RU.58841, bicalutamide, cyproterone.acetate",1.20065945054642,0.511449283499556,FALSE +"transcriptomics","Pearson.est","antioxidant",0.51222,1.26,0.185,671,0.396,"trolox, mesna, chlorogenic.acid, benfotiamine, taurine",0.732828271596986,0.402304814074488,FALSE +"transcriptomics","Pearson.est","AP inhibitor",0.381,0.918,0.587,96,0.823,"idronoxil",0.231361898752386,0.0846001647877302,FALSE +"transcriptomics","Pearson.est","ATPase inhibitor",0.4364,1.05,0.405,323,0.711,"digoxin, evodiamine, blebbistatin...., ouabain, digitoxigenin, digitoxin",0.392544976785331,0.148130399270234,FALSE +"transcriptomics","Pearson.est","Aurora kinase inhibitor",0.62133,1.51,0.0448,251,0.35,"PF.03814735, AT.9283, barasertib, SNS.314, AMG900, KW.2449, hesperadin, danusertib, ENMD.2076, tozasertib, alisertib, GSK1070916, barasertib.HQPA",1.34872198600186,0.455931955649724,FALSE +"transcriptomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.3898,0.937,0.578,768,0.803,"valnemulin, radezolid, dirithromycin, azalomycin.b, tedizolid, tilmicosin",0.238072161579471,0.095284454721319,FALSE +"transcriptomics","Pearson.est","bacterial DNA gyrase inhibitor",0.39298,0.963,0.524,198,0.808,"novobiocin, finafloxacin",0.280668713016273,0.0925886392254138,FALSE +"transcriptomics","Pearson.est","BCL inhibitor",0.57908,1.39,0.0801,235,0.303,"TW.37, gossypol, venetoclax",1.09636748391576,0.518557371497695,FALSE +"transcriptomics","Pearson.est","Bcr.Abl kinase inhibitor",0.66348,1.57,0.036,225,0.306,"GZD824, ponatinib, tozasertib, flumatinib, nilotinib",1.44369749923271,0.51427857351842,FALSE +"transcriptomics","Pearson.est","benzodiazepine receptor agonist",0.20268,0.489,0.984,596,0.998,"eprinomectin, zaleplon, temazepam, ivermectin, ZK.93423",0.00700490156865849,0.000869458712628891,FALSE +"transcriptomics","Pearson.est","bromodomain inhibitor",0.27519,0.665,0.88,800,0.972,"bromosporine, PFI.1, I.BET.762",0.0555173278498314,0.0123337350737254,FALSE +"transcriptomics","Pearson.est","calcium channel blocker",0.27812,0.671,0.872,370,0.983,"carboxyamidotriazole, cinnarazine, pranidipine",0.0594835150674328,0.00744648216786438,FALSE +"transcriptomics","Pearson.est","CC chemokine receptor antagonist",0.5806,1.41,0.0856,490,0.339,"UNBS.5162, SB.225002, navarixin, PF.04136309, RS.504393, MK.0812",1.06752623532285,0.469800301796918,FALSE +"transcriptomics","Pearson.est","CDK inhibitor",0.40186,0.958,0.525,406,0.799,"palbociclib, abemaciclib, AZD5438, PHA.848125, R547, indisulam, ribociclib, kenpaullone, JNJ.7706621, BMS.265246",0.279840696594043,0.0974532206860086,FALSE +"transcriptomics","Pearson.est","CHK inhibitor",-0.33033,-0.89,0.557,476,0.792,"SB.218078, PF.477736, AZD7762, CHIR.124, SCH.900776, LY2606368, LY2603618",0.254144804826271,0.101274818410506,FALSE +"transcriptomics","Pearson.est","cyclooxygenase inhibitor",0.30161,0.721,0.826,580,0.98,"tepoxalin, piroxicam, indoprofen, suxibuzone, meloxicam, ketoprofen, phenazone, FR.122047",0.0830199526796178,0.00877392430750515,FALSE +"transcriptomics","Pearson.est","cytochrome P450 inhibitor",0.5096,1.23,0.21,413,0.435,"itraconazole, metyrapone, cobicistat, morin",0.677780705266081,0.361510743045363,FALSE +"transcriptomics","Pearson.est","DNA alkylating agent",0.52809,1.29,0.174,368,0.402,"melphalan, carboplatin, carmustine, streptozotocin, TH.302, temozolomide, mitomycin.c",0.7594507517174,0.39577394691553,FALSE +"transcriptomics","Pearson.est","DNA inhibitor",0.41865,1.01,0.45,638,0.725,"melphalan, valrubicin, carboplatin, carmustine, teroxirone, chlorambucil, oxaliplatin, nimorazole, tirapazamine, pibenzimol, mechlorethamine",0.346787486224656,0.139661993429006,FALSE +"transcriptomics","Pearson.est","DNA methyltransferase inhibitor",-0.36253,-1.04,0.347,1371,0.623,"azacitidine, SGI.1027",0.459670525209126,0.20551195334083,FALSE +"transcriptomics","Pearson.est","DNA polymerase inhibitor",0.60364,1.43,0.0823,236,0.322,"idoxuridine, trifluridine, foscarnet",1.08460016478773,0.492144128304169,FALSE +"transcriptomics","Pearson.est","DNA synthesis inhibitor",0.56425,1.37,0.121,373,0.309,"anisomycin, floxuridine, cyclocytidine, CB.10.277, azodicarbonamide, nelarabine, mitomycin.c, artesunate",0.91721462968355,0.510041520575165,FALSE +"transcriptomics","Pearson.est","dopamine receptor antagonist",0.36056,0.882,0.638,603,0.875,"raclopride, amisulpride, paliperidone, UH.232...., thioproperazine, isofloxythepin, sertindole, domperidone, mesoridazine",0.195179321278838,0.0579919469776868,FALSE +"transcriptomics","Pearson.est","estrogen receptor agonist",0.32797,0.794,0.742,640,0.933,"estrone, PPT, estradiol, ethinyl.estradiol",0.129596094720973,0.0301183562535,FALSE +"transcriptomics","Pearson.est","estrogen receptor antagonist",0.33908,0.811,0.728,506,0.925,"fulvestrant, danazol",0.137868620686963,0.0338582672609674,FALSE +"transcriptomics","Pearson.est","FGFR inhibitor",0.50189,1.2,0.25,402,0.477,"dovitinib, regorafenib, erdafitinib, nintedanib, MK.2461",0.602059991327962,0.321481620959886,FALSE +"transcriptomics","Pearson.est","FLT3 inhibitor",0.63527,1.53,0.0501,392,0.351,"dovitinib, KW.2449, ponatinib, TG.101348, ENMD.2076, tozasertib, quizartinib, gilteritinib, midostaurin, sunitinib, lestaurtinib, sorafenib",1.30016227413275,0.454692883534176,FALSE +"transcriptomics","Pearson.est","glucocorticoid receptor agonist",0.16994,0.413,0.994,629,0.997,"fluticasone.propionate, prednisolone, hydrocortisone, rimexolone, fluocinolone.acetonide, halobetasol.propionate, triamcinolone, prednisolone.acetate",0.00261361560268669,0.00130484168834428,FALSE +"transcriptomics","Pearson.est","glutamate receptor antagonist",-0.4446,-1.29,0.144,638,0.39,"ACDPP, MTPG, diazooxonorleucine, SIB.1757, tiletamine, IEM1754, JNJ.16259685, CPP, latrepirdine, felbamate, kynurenic.acid, CGP.37849, LY456236",0.84163750790475,0.408935392973501,FALSE +"transcriptomics","Pearson.est","glycogen synthase kinase inhibitor",0.28675,0.69,0.873,430,0.98,"tideglusib, kenpaullone, TWS.119",0.0589857562944303,0.00877392430750515,FALSE +"transcriptomics","Pearson.est","growth factor receptor inhibitor",0.6058,1.44,0.0804,388,0.323,"PHA.848125, danusertib, AZD3463, GSK1838705A, lestaurtinib",1.09474395125155,0.490797477668897,FALSE +"transcriptomics","Pearson.est","HCV inhibitor",0.52227,1.27,0.171,207,0.406,"narlaprevir, mericitabine",0.767003889607846,0.391473966422806,FALSE +"transcriptomics","Pearson.est","HDAC inhibitor",-0.43359,-1.29,0.162,617,0.39,"dacinostat, entinostat, belinostat, resminostat, RG2833, trichostatin.a, scriptaid, RGFP966, AR.42, NSC.3852, R306465, chidamide, givinostat, nexturastat.a, ACY.1215, PCI.24781, vorinostat, M.344, SB.939, panobinostat, pyroxamide, romidepsin, tacedinaline, JNJ.26481585, mocetinostat",0.790484985457369,0.408935392973501,FALSE +"transcriptomics","Pearson.est","histamine receptor antagonist",0.28671,0.694,0.849,658,0.993,"pheniramine, cimetidine, tiotidine, nizatidine, famotidine, zolantidine, ICI.162846, BF2.649, astemizole",0.0710923097560473,0.00305075150461883,FALSE +"transcriptomics","Pearson.est","HMGCR inhibitor",0.80486,1.94,0.00123,104,0.024,"fluvastatin, atorvastatin, mevastatin, pitavastatin",2.9100948885606,1.61978875828839,TRUE +"transcriptomics","Pearson.est","HSP inhibitor",0.42561,1.03,0.427,261,0.737,"SNX.2112, NVP.AUY922, NMS.E973, PU.H71, ganetespib",0.369572124974976,0.132532512140949,FALSE +"transcriptomics","Pearson.est","JAK inhibitor",0.46895,1.13,0.3,145,0.59,"AT.9283, AZ960, TG.101348, TG.101209, tozasertib",0.522878745280338,0.229147988357856,FALSE +"transcriptomics","Pearson.est","KIT inhibitor",0.41165,1.01,0.456,765,0.725,"KI.8751, regorafenib, pazopanib, OSI.930, midostaurin, sunitinib, sorafenib, masitinib, cediranib, tandutinib, motesanib, vatalanib, lenvatinib",0.341035157335565,0.139661993429006,FALSE +"transcriptomics","Pearson.est","MDM inhibitor",0.86919,2.08,0,191,0.00384,"idasanutlin, nutlin.3, serdemetan, AMG.232, CGM097",Inf,2.41566877563247,TRUE +"transcriptomics","Pearson.est","MEK inhibitor",-0.29881,-0.874,0.577,427,0.764,"arctigenin, U.0126, PD.0325901, PD.318088, refametinib, nobiletin, AZD8330, Ro.4987655, TAK.733, cobimetinib, PD.184352, PD.198306, AS.703026, MEK162, selumetinib, PD.98059, MEK1.2.inhibitor, trametinib, BIX.02188",0.238824186844269,0.11690664142431,FALSE +"transcriptomics","Pearson.est","MET inhibitor",0.31428,0.762,0.786,238,0.962,"LY2801653, PHA.665752",0.104577453960592,0.0168249279621871,FALSE +"transcriptomics","Pearson.est","microtubule inhibitor",0.74948,1.83,0.00596,249,0.065,"vinblastine, vinflunine, secnidazole, podophyllotoxin, D.64131, cabazitaxel",2.22475374025976,1.18708664335714,TRUE +"transcriptomics","Pearson.est","mTOR inhibitor",0.35239,0.854,0.657,693,0.889,"ku.0063794, torin.1, AZD8055, NVP.BEZ235, WYE.354, MLN0128, WAY.600, PKI.179, deforolimus, XL388, LY3023414, AZD2014, palomid.529, PF.04691502, LY303511, voxtalisib, SB.2343",0.182434630440219,0.0510982390297863,FALSE +"transcriptomics","Pearson.est","NFkB pathway inhibitor",0.23578,0.572,0.958,549,1,"betulinic.acid, bortezomib, BAY.11.7082, EVP4593",0.0186344909214556,0,FALSE +"transcriptomics","Pearson.est","opioid receptor agonist",0.55941,1.35,0.131,466,0.327,"trimebutine, cebranopadol, salvinorin.a, spiradoline",0.882728704344236,0.485452247339714,FALSE +"transcriptomics","Pearson.est","p38 MAPK inhibitor",-0.30326,-0.872,0.633,437,0.717,"skepinone.l, SB.242235, VX.702, TAK.715, CMPD.1, SB.239063, talmapimod",0.198596289982645,0.1444808443322,FALSE +"transcriptomics","Pearson.est","PARP inhibitor",0.57655,1.37,0.11,602,0.309,"talazoparib, AG.14361, niraparib, olaparib, E7449, PJ.34, AZD2461",0.958607314841775,0.510041520575165,FALSE +"transcriptomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.45968,1.11,0.339,392,0.615,"KI.8751, dovitinib, crenolanib, ponatinib, regorafenib, pazopanib, CP.673451, axitinib, nintedanib, sunitinib, sorafenib",0.469800301796918,0.211124884224583,FALSE +"transcriptomics","Pearson.est","phosphatase inhibitor",0.42138,1.01,0.459,522,0.725,"GSK2830371, bis.maltolato.oxovanadium.IV., sodium.stibogluconate, CID.5458317, BVT.948",0.338187314462739,0.139661993429006,FALSE +"transcriptomics","Pearson.est","phosphodiesterase inhibitor",0.35736,0.866,0.627,337,0.885,"GSK256066, anagrelide, YM.976",0.202732459169284,0.0530567293021746,FALSE +"transcriptomics","Pearson.est","PI3K inhibitor",-0.21553,-0.631,0.913,1367,1,"CH5132799, PF.05212384, alpelisib, taselisib",0.039529222465701,0,FALSE +"transcriptomics","Pearson.est","PLK inhibitor",0.73976,1.77,0.00611,382,0.0891,"rigosertib, volasertib, GSK461364, NMS.1286937, BI.2536, HMN.214, GW.843682X",2.21395878975745,1.05012229596313,TRUE +"transcriptomics","Pearson.est","potassium channel blocker",0.50069,1.19,0.254,726,0.482,"meglitinide, dofetilide, ML133, oleoylethanolamide, ibutilide, mepivacaine",0.595166283380062,0.31695296176115,FALSE +"transcriptomics","Pearson.est","PPAR receptor agonist",-0.43928,-1.25,0.186,633,0.395,"ciprofibrate, clofibrate, oleoylethanolamide, GW.501516, fenofibrate, S26948, pterostilbene",0.730487055782084,0.40340290437354,FALSE +"transcriptomics","Pearson.est","progesterone receptor agonist",0.21279,0.511,0.98,772,1,"tanaproget, danazol, nomegestrol.acetate, norethindrone, dienogest",0.00877392430750515,0,FALSE +"transcriptomics","Pearson.est","proteasome inhibitor",0.52318,1.26,0.165,369,0.396,"MG.132, ixazomib, bortezomib",0.782516055786094,0.402304814074488,FALSE +"transcriptomics","Pearson.est","protein synthesis inhibitor",0.58007,1.4,0.0889,119,0.302,"mercaptopurine, anguidine, homoharringtonine, cycloheximide, brefeldin.a, harringtonine",1.05109823902979,0.519993057042849,FALSE +"transcriptomics","Pearson.est","protein tyrosine kinase inhibitor",-0.58296,-1.63,0.0433,1354,0.219,"BMS.599626, AV.412, CP.724714",1.36351210364663,0.659555885159882,TRUE +"transcriptomics","Pearson.est","RAF inhibitor",0.59544,1.47,0.0662,526,0.369,"regorafenib, dabrafenib, SB.590885, GDC.0879, RAF265, vemurafenib, sorafenib, TAK.632, LGX818, CEP.32496, PLX.4720",1.1791420105603,0.43297363384094,FALSE +"transcriptomics","Pearson.est","RET tyrosine kinase inhibitor",0.39031,0.955,0.531,392,0.787,"regorafenib, sunitinib, sorafenib",0.274905478918531,0.104025267640935,FALSE +"transcriptomics","Pearson.est","retinoid receptor agonist",-0.3375,-0.962,0.468,486,0.715,"adarotene, bexarotene, fenretinide, LE.135, tamibarotene, adapalene, AM.580, CD.437",0.329754146925876,0.145693958198919,FALSE +"transcriptomics","Pearson.est","ribonucleotide reductase inhibitor",0.65753,1.62,0.0271,394,0.253,"clofarabine, cladribine, triapine, fludarabine.phosphate, LY2334737, pentostatin, gemcitabine, fludarabine",1.56703070912559,0.596879478824182,FALSE +"transcriptomics","Pearson.est","serotonin receptor agonist",0.57158,1.4,0.0956,410,0.302,"aripiprazole, NAN.190, SR.57227A, ipsapirone",1.0195421077239,0.519993057042849,FALSE +"transcriptomics","Pearson.est","serotonin receptor antagonist",0.5316,1.29,0.173,460,0.402,"aripiprazole, SB.200646, paliperidone, lerisetron, pirenperone, SB.216641, sertindole",0.761953896871205,0.39577394691553,FALSE +"transcriptomics","Pearson.est","sodium channel blocker",0.27088,0.66,0.88,264,0.96,"butamben, quinidine, ajmaline",0.0555173278498314,0.0177287669604316,FALSE +"transcriptomics","Pearson.est","src inhibitor",-0.39641,-1.2,0.22,1412,0.423,"ZM.306416, saracatinib",0.657577319177794,0.373659632624958,FALSE +"transcriptomics","Pearson.est","sterol demethylase inhibitor",0.53593,1.28,0.18,619,0.404,"posaconazole, ketoconazole, chlormidazole, lanoconazole",0.744727494896694,0.393618634889395,FALSE +"transcriptomics","Pearson.est","TGF beta receptor inhibitor",-0.47357,-1.32,0.156,1362,0.475,"LY2109761, repsox",0.806875401645538,0.323306390375133,FALSE +"transcriptomics","Pearson.est","thymidylate synthase inhibitor",0.7991,1.95,0.00126,189,0.0322,"trifluridine, raltitrexed, carmofur, ftorafur",2.89962945488244,1.49214412830417,TRUE +"transcriptomics","Pearson.est","topoisomerase inhibitor",0.60559,1.46,0.065,171,0.308,"idarubicin, topotecan, teniposide, TAS.103, amsacrine, voreloxin, etoposide.phosphate, valrubicin, nemorubicin, daunorubicin, rubitecan, amonafide, doxorubicin",1.18708664335714,0.511449283499556,FALSE +"transcriptomics","Pearson.est","tubulin polymerization inhibitor",0.62294,1.48,0.0675,295,0.383,"verubulin, vinblastine, taltobulin, BNC105, combretastatin.A.4, vindesine, KX2.391, CYT.997, fosbretabulin, podophyllotoxin, dolastatin.10, vincristine, epothilone.b, albendazole, ABT.751, vinorelbine, docetaxel, plinabulin",1.17069622716898,0.416801226031377,FALSE +"transcriptomics","Pearson.est","tyrosine kinase inhibitor",-0.20581,-0.591,0.956,1354,0.938,"BMS.599626, AV.412, vandetanib, CP.724714",0.0195421077238999,0.0277971616209356,FALSE +"transcriptomics","Pearson.est","VEGFR inhibitor",0.21469,0.515,0.977,402,1,"KI.8751, dovitinib, regorafenib, ENMD.2076, pazopanib, axitinib, OSI.930, nintedanib, RAF265, sunitinib, sorafenib, MK.2461",0.0101054362812269,0,FALSE +"transcriptomics","Pearson.est","vitamin D receptor agonist",-0.81854,-2.34,0,1312,0.013,"tacalcitol, calcitriol, paricalcitol, maxacalcitol",Inf,1.88605664769316,TRUE +"proteomics","Pearson.est","EGFR inhibitor",-0.86578,-2.26,0,1383,0.00205,"GW.583340, AEE788, CUDC.101, rociletinib, TAK.285, PD.153035, icotinib, CP.724714, WZ.4002, BIBU.1361, vandetanib, BMS.599626, PD.168393, ARRY.334543, AST.1306, WZ8040, gefitinib, XL.647, erlotinib, neratinib, tucatinib, lapatinib, BMS.690514, pelitinib, AZD8931, dacomitinib, poziotinib, afatinib, canertinib, osimertinib",Inf,2.68824613894425,TRUE +"proteomics","Pearson.est","Abl kinase inhibitor",0.33477,0.789,0.734,351,0.82,"nilotinib, GZD824, tozasertib, bafetinib, ponatinib, KW.2449",0.134303940083929,0.0861861476162833,FALSE +"proteomics","Pearson.est","acetylcholine receptor agonist",0.52774,1.25,0.209,687,0.551,"nicotine, tremorine, xanomeline, nefiracetam, oxiracetam, pilocarpine",0.679853713888946,0.258848401148215,FALSE +"proteomics","Pearson.est","acetylcholine receptor antagonist",0.39259,0.92,0.581,574,0.688,"methscopolamine, diphemanil, iododexetimide, darifenacin",0.235823867609669,0.162411561764489,FALSE +"proteomics","Pearson.est","adenosine receptor antagonist",-0.57668,-1.53,0.0649,1409,0.225,"MRS.1220, CGS.15943",1.18775530319963,0.647817481888638,FALSE +"proteomics","Pearson.est","adrenergic receptor agonist",-0.18233,-0.475,0.985,1081,1,"oxymetazoline, isoetharine, ritodrine, epinephrine, lidamidine, terbutaline, methyldopa, midodrine, isoxsuprine",0.00656376950238827,0,FALSE +"proteomics","Pearson.est","adrenergic receptor antagonist",0.27701,0.651,0.896,488,0.949,"idazoxan, carvedilol, oxprenolol, levobunolol, metoprolol, atenolol......, naftidrofuryl",0.0476919903378748,0.0227337875727074,FALSE +"proteomics","Pearson.est","AKT inhibitor",-0.62476,-1.59,0.0578,1308,0.198,"uprosertib, GSK2110183, triciribine, CCT128930, AZD5363",1.23807216157947,0.703334809738469,FALSE +"proteomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41969,-1.11,0.314,1258,0.807,"CEP.37440, GW.788388, NVP.TAE684, SB.505124, AP26113, brigatinib",0.503070351926785,0.0931264652779296,FALSE +"proteomics","Pearson.est","androgen receptor antagonist",0.38972,0.924,0.57,512,0.696,"nilutamide, flutamide",0.244125144327509,0.157390760389438,FALSE +"proteomics","Pearson.est","antioxidant",0.49166,1.16,0.273,446,0.572,"taurine, mesna, trolox",0.563837352959244,0.242603971206976,FALSE +"proteomics","Pearson.est","AP inhibitor",0.51096,1.2,0.264,608,0.591,"idronoxil, GDC.0152, LCL.161, birinapant, embelin",0.578396073130169,0.228412519118745,FALSE +"proteomics","Pearson.est","ATPase inhibitor",0.59758,1.44,0.09,233,0.595,"digoxin, oligomycin.a, digitoxigenin, NMS.873, evodiamine, k.strophanthidin",1.04575749056068,0.22548303427145,FALSE +"proteomics","Pearson.est","Aurora kinase inhibitor",0.57358,1.35,0.13,358,0.513,"MK.5108, barasertib, barasertib.HQPA, SNS.314, AMG900, MK.8745, danusertib, tozasertib, CCT137690, ENMD.2076, hesperadin, AT.9283, KW.2449, PF.03814735",0.886056647693163,0.289882634888184,FALSE +"proteomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.45114,1.08,0.387,222,0.574,"valnemulin, radezolid",0.412289034981089,0.241088107602027,FALSE +"proteomics","Pearson.est","bacterial DNA gyrase inhibitor",0.35173,0.822,0.677,810,0.806,"lomefloxacin, novobiocin, sparfloxacin, nadifloxacin, finafloxacin, norfloxacin",0.169411331314856,0.0936649581949093,FALSE +"proteomics","Pearson.est","BCL inhibitor",0.48376,1.15,0.305,89,0.573,"gossypol, TW.37",0.515700160653214,0.24184537803261,FALSE +"proteomics","Pearson.est","Bcr.Abl kinase inhibitor",0.44083,1.03,0.437,323,0.605,"nilotinib, GZD824, tozasertib, bafetinib, ponatinib",0.359518563029578,0.218244625347531,FALSE +"proteomics","Pearson.est","benzodiazepine receptor agonist",0.25994,0.611,0.915,685,0.967,"bentazepam, nefiracetam, lorazepam, indiplon, zaleplon",0.0385789059335517,0.0145735259169983,FALSE +"proteomics","Pearson.est","bromodomain inhibitor",0.39787,0.93,0.557,525,0.701,"bromosporine, OTX015",0.254144804826271,0.154281982033341,FALSE +"proteomics","Pearson.est","calcium channel blocker",0.33847,0.795,0.727,184,0.827,"carboxyamidotriazole, pranidipine",0.138465589140962,0.0824944904474534,FALSE +"proteomics","Pearson.est","CC chemokine receptor antagonist",0.43271,1.03,0.433,235,0.605,"SB.225002, UNBS.5162",0.363512103646635,0.218244625347531,FALSE +"proteomics","Pearson.est","CDK inhibitor",0.42795,0.994,0.476,545,0.638,"abemaciclib, palbociclib, PHA.848125, R547, JNJ.7706621, NU6027, dinaciclib, PHA.793887, ribociclib, AZD5438, BMS.265246, indisulam",0.322393047279507,0.195179321278838,FALSE +"proteomics","Pearson.est","CHK inhibitor",-0.38712,-1.01,0.417,1242,0.803,"CHIR.124, LY2603618",0.379863945026242,0.095284454721319,FALSE +"proteomics","Pearson.est","cyclooxygenase inhibitor",0.21637,0.509,0.975,327,0.976,"tepoxalin, piroxicam, sulfasalazine, suxibuzone",0.0109953843014632,0.0105501823333082,FALSE +"proteomics","Pearson.est","cytochrome P450 inhibitor",0.46704,1.1,0.349,594,0.583,"cobicistat, PF.4981517, metyrapone, clotrimazole",0.45717457304082,0.234331445240986,FALSE +"proteomics","Pearson.est","DNA alkylating agent",0.51533,1.19,0.283,347,0.568,"carboplatin, carmustine, dianhydrogalactitol, mitomycin.c, cisplatin, temozolomide, melphalan, TH.302",0.54821356447571,0.245651664288981,FALSE +"proteomics","Pearson.est","DNA inhibitor",0.55777,1.3,0.147,277,0.513,"carboplatin, chlorambucil, valrubicin, carmustine, pibenzimol, oxaliplatin, teroxirone, melphalan",0.832682665251824,0.289882634888184,FALSE +"proteomics","Pearson.est","DNA methyltransferase inhibitor",0.45092,1.06,0.39,7,0.582,"disulfiram",0.408935392973501,0.235077015350112,FALSE +"proteomics","Pearson.est","DNA polymerase inhibitor",0.48547,1.14,0.3,381,0.556,"foscarnet, idoxuridine, trifluridine, menadione",0.522878745280338,0.254925208417942,FALSE +"proteomics","Pearson.est","DNA synthesis inhibitor",0.55464,1.31,0.145,578,0.518,"cyclocytidine, mitomycin.c, cisplatin, floxuridine, CB.10.277, altretamine, anisomycin, artesunate, enocitabine, azodicarbonamide, artemisinin",0.838631997765025,0.285670240254767,FALSE +"proteomics","Pearson.est","dopamine receptor antagonist",0.2375,0.555,0.952,590,0.989,"raclopride, amisulpride, paliperidone, nemonapride, sertindole, isofloxythepin, thioproperazine, UH.232....",0.0213630516155257,0.0048037084028206,FALSE +"proteomics","Pearson.est","estrogen receptor agonist",-0.27569,-0.727,0.772,397,0.951,"estradiol.cypionate, PPT, estradiol, estrone, ethinyl.estradiol, erteberel, levonorgestrel, equol",0.112382699664264,0.0218194830625861,FALSE +"proteomics","Pearson.est","estrogen receptor antagonist",-0.33843,-0.897,0.551,1314,0.851,"raloxifene, clomifene, tamoxifen",0.258848401148215,0.0700704399154121,FALSE +"proteomics","Pearson.est","FGFR inhibitor",0.53541,1.23,0.194,292,0.571,"erdafitinib, regorafenib, dovitinib, nintedanib, lenvatinib",0.712198270069774,0.243363891754152,FALSE +"proteomics","Pearson.est","FLT3 inhibitor",0.56887,1.35,0.125,484,0.513,"TG.101348, dovitinib, tozasertib, sorafenib, ENMD.2076, tyrphostin.AG.1296, ponatinib, KW.2449, gilteritinib, GTP.14564, lestaurtinib",0.903089986991944,0.289882634888184,FALSE +"proteomics","Pearson.est","glucocorticoid receptor agonist",-0.21561,-0.548,0.961,440,1,"dexamethasone.acetate, halcinonide, triamcinolone, beclomethasone.dipropionate, halobetasol.propionate, desonide, flumethasone.pivalate, rimexolone, prednisolone.hemisuccinate, piretanide, prednisolone, difluprednate, fluorometholone, methylprednisolone, deflazacort, fluocinolone.acetonide, clobetasol.propionate, flumethasone, prednisolone.acetate, fludroxycortide, ciclesonide, betamethasone, hydrocortisone, triamcinolone.acetonide",0.0172766123314547,0,FALSE +"proteomics","Pearson.est","glutamate receptor antagonist",-0.2087,-0.542,0.972,1406,1,"latrepirdine",0.0123337350737254,0,FALSE +"proteomics","Pearson.est","glycogen synthase kinase inhibitor",-0.36762,-0.944,0.49,529,0.877,"CHIR.99021, tideglusib, CHIR.98014, TWS.119, kenpaullone, GSK.3.inhibitor.IX, indirubin, AZD2858, LY2090314",0.309803919971486,0.0570004066339595,FALSE +"proteomics","Pearson.est","growth factor receptor inhibitor",0.42278,0.99,0.489,195,0.632,"PHA.848125, danusertib",0.31069114087638,0.199282921717615,FALSE +"proteomics","Pearson.est","HCV inhibitor",0.49852,1.2,0.266,608,0.591,"mericitabine, narlaprevir, Ro.9187, embelin",0.575118363368933,0.228412519118745,FALSE +"proteomics","Pearson.est","HDAC inhibitor",-0.14547,-0.372,0.996,207,0.999,"NSC.3852, chidamide, RGFP966, dacinostat, resminostat, ACY.1215, pyroxamide, entinostat, nexturastat.a, AR.42, M.344, trichostatin.a, scriptaid, belinostat, R306465, PCI.24781, givinostat, RG2833, romidepsin, vorinostat, tacedinaline, SB.939, mocetinostat, panobinostat, JNJ.26481585",0.00174066157630127,0.000434511774017692,FALSE +"proteomics","Pearson.est","histamine receptor antagonist",-0.34552,-0.912,0.526,1294,0.879,"levocetirizine, ebastine, ranitidine, terfenadine, zolantidine, chloropyramine",0.279014255846261,0.0560111249262281,FALSE +"proteomics","Pearson.est","HMGCR inhibitor",0.85397,1.99,0.0014,90,0.0228,"mevastatin, atorvastatin, fluvastatin, pitavastatin",2.85387196432176,1.64206515299955,TRUE +"proteomics","Pearson.est","HSP inhibitor",-0.30589,-0.821,0.656,1275,0.89,"VER.49009, KW.2478, guanidine, alvespimycin, tanespimycin",0.18309616062434,0.0506099933550872,FALSE +"proteomics","Pearson.est","JAK inhibitor",0.49239,1.16,0.281,338,0.572,"AZ960, TG.101348, baricitinib, WHI.P154, TG.101209, tozasertib, AT.9283",0.55129368009492,0.242603971206976,FALSE +"proteomics","Pearson.est","KIT inhibitor",0.43143,1.01,0.47,339,0.625,"pazopanib, regorafenib, KI.8751, sorafenib, lenvatinib, motesanib",0.327902142064283,0.204119982655925,FALSE +"proteomics","Pearson.est","MDM inhibitor",0.67888,1.57,0.0299,88,0.522,"AMG.232, idasanutlin, nutlin.3",1.52432881167557,0.282329496997738,FALSE +"proteomics","Pearson.est","MEK inhibitor",-0.39583,-1.03,0.436,1131,0.827,"cobimetinib, Ro.4987655, selumetinib, nobiletin, PD.184352, AS.703026, TAK.733, trametinib, AZD8330",0.360513510731414,0.0824944904474534,FALSE +"proteomics","Pearson.est","MET inhibitor",0.23292,0.551,0.967,670,0.974,"PHA.665752, AMG458, LY2801653, NVP.BVU972",0.0145735259169983,0.0114410431213845,FALSE +"proteomics","Pearson.est","microtubule inhibitor",0.60121,1.41,0.0924,286,0.563,"vinblastine, vinflunine, D.64131, triclabendazole",1.03432802877989,0.249491605148654,FALSE +"proteomics","Pearson.est","mTOR inhibitor",0.45668,1.08,0.394,334,0.574,"ku.0063794, XL388, deforolimus, MLN0128, WAY.600, AZD2014, torin.1, PI.103, PF.04691502, PP242, NVP.BEZ235",0.404503778174426,0.241088107602027,FALSE +"proteomics","Pearson.est","NFkB pathway inhibitor",0.47031,1.12,0.349,364,0.578,"EVP4593, betulinic.acid, BAY.11.7082, parthenolide",0.45717457304082,0.238072161579471,FALSE +"proteomics","Pearson.est","opioid receptor agonist",0.41435,0.985,0.485,312,0.626,"trimebutine, spiradoline, salvinorin.a",0.314258261397736,0.20342566678957,FALSE +"proteomics","Pearson.est","p38 MAPK inhibitor",-0.68975,-1.75,0.0379,1013,0.172,"SB.242235, skepinone.l, VX.702, talmapimod, TAK.715, SB.239063",1.42136079003193,0.764471553092451,TRUE +"proteomics","Pearson.est","PARP inhibitor",0.61495,1.43,0.0714,302,0.561,"AG.14361, talazoparib, olaparib, AZD2461, niraparib",1.14630178822383,0.251037138743839,FALSE +"proteomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.49138,1.14,0.321,339,0.556,"pazopanib, regorafenib, axitinib, dovitinib, nintedanib, KI.8751, CP.673451, sorafenib, lenvatinib, ponatinib, motesanib",0.493494967595128,0.254925208417942,FALSE +"proteomics","Pearson.est","phosphatase inhibitor",0.54946,1.27,0.199,6,0.557,"bis.maltolato.oxovanadium.IV., GSK2830371",0.701146923590293,0.254144804826271,FALSE +"proteomics","Pearson.est","phosphodiesterase inhibitor",0.57887,1.33,0.161,270,0.499,"GSK256066, anagrelide, zardaverine",0.79317412396815,0.30189945437661,FALSE +"proteomics","Pearson.est","PI3K inhibitor",0.2899,0.683,0.856,468,0.934,"idelalisib, ZSTK.474, buparlisib, AZD6482, PI.103, PF.04691502, NVP.BEZ235, BGT226, CUDC.907, GDC.0941, SB.2343, LY3023414",0.0675262353228468,0.0296531237699066,FALSE +"proteomics","Pearson.est","PLK inhibitor",0.74671,1.76,0.00533,305,0.232,"volasertib, rigosertib, GW.843682X, BI.2536, NMS.1286937, GSK461364",2.27327279097343,0.6345120151091,TRUE +"proteomics","Pearson.est","potassium channel blocker",0.57492,1.33,0.152,456,0.499,"ML133, ibutilide, dofetilide, mepivacaine",0.818156412055227,0.30189945437661,FALSE +"proteomics","Pearson.est","PPAR receptor agonist",0.54565,1.25,0.213,30,0.551,"clofibrate",0.671620396561262,0.258848401148215,FALSE +"proteomics","Pearson.est","progesterone receptor agonist",0.4516,1.06,0.383,142,0.582,"norethindrone, tanaproget, nomegestrol.acetate",0.416801226031377,0.235077015350112,FALSE +"proteomics","Pearson.est","proteasome inhibitor",0.39205,0.913,0.577,95,0.686,"MG.132",0.238824186844269,0.163675884293248,FALSE +"proteomics","Pearson.est","protein synthesis inhibitor",0.59329,1.4,0.114,352,0.497,"mercaptopurine, harringtonine, anguidine, homoharringtonine, thiostrepton, clofoctol, emetine, cycloheximide, bruceantin",0.943095148663527,0.303643611266668,FALSE +"proteomics","Pearson.est","protein tyrosine kinase inhibitor",-0.69758,-1.84,0.0144,1418,0.151,"CP.724714, BMS.599626, AV.412",1.84163750790475,0.821023052706831,TRUE +"proteomics","Pearson.est","RAF inhibitor",0.721,1.69,0.00824,354,0.285,"regorafenib, TAK.632, SB.590885, RAF265, dabrafenib, vemurafenib, sorafenib, AZ.628, LGX818, PLX.4720, GDC.0879",2.08407278830288,0.54515513999149,FALSE +"proteomics","Pearson.est","RET tyrosine kinase inhibitor",-0.31715,-0.85,0.622,1422,0.892,"vandetanib",0.206209615309181,0.0496351456238769,FALSE +"proteomics","Pearson.est","retinoid receptor agonist",0.47211,1.1,0.347,166,0.583,"adapalene, fenretinide, LE.135",0.459670525209126,0.234331445240986,FALSE +"proteomics","Pearson.est","ribonucleotide reductase inhibitor",0.60094,1.44,0.0814,200,0.595,"clofarabine, triapine, fludarabine.phosphate, cladribine, pentostatin",1.0893755951108,0.22548303427145,FALSE +"proteomics","Pearson.est","serotonin receptor agonist",0.58925,1.4,0.114,1,0.497,"aripiprazole",0.943095148663527,0.303643611266668,FALSE +"proteomics","Pearson.est","serotonin receptor antagonist",0.50508,1.19,0.259,183,0.568,"aripiprazole, pirenperone, lerisetron",0.586700235918748,0.245651664288981,FALSE +"proteomics","Pearson.est","sodium channel blocker",0.46334,1.09,0.364,218,0.586,"cibenzoline, butamben, quinidine",0.438898616350944,0.232102383981909,FALSE +"proteomics","Pearson.est","src inhibitor",-0.6257,-1.63,0.0616,1360,0.196,"bosutinib, dasatinib, ZM.306416, saracatinib",1.21041928783557,0.707743928643524,FALSE +"proteomics","Pearson.est","sterol demethylase inhibitor",0.58924,1.37,0.109,404,0.537,"chlormidazole, posaconazole, ketoconazole",0.962573502059376,0.270025714300444,FALSE +"proteomics","Pearson.est","TGF beta receptor inhibitor",-0.68019,-1.74,0.0374,1223,0.144,"LY2109761, D.4476, SB.431542, repsox",1.42712839779952,0.84163750790475,TRUE +"proteomics","Pearson.est","thymidylate synthase inhibitor",0.63087,1.45,0.0806,348,0.748,"doxifluridine, trifluridine, ftorafur",1.09366495819491,0.126098402135539,FALSE +"proteomics","Pearson.est","topoisomerase inhibitor",0.63755,1.51,0.0548,329,0.629,"etoposide.phosphate, doxorubicin, TAS.103, teniposide, voreloxin, topotecan, idarubicin, valrubicin, epirubicin, dexrazoxane, amsacrine, nemorubicin, mitoxantrone, daunorubicin, SN.38, etoposide",1.26121944151563,0.201349354554731,FALSE +"proteomics","Pearson.est","tubulin polymerization inhibitor",0.50064,1.17,0.251,486,0.591,"BNC105, taltobulin, verubulin, vinblastine, vindesine, KX2.391, vinorelbine, fosbretabulin, combretastatin.A.4, mebendazole, epothilone.d, ABT.751, vincristine, flubendazole, fenbendazole",0.600326278518962,0.228412519118745,FALSE +"proteomics","Pearson.est","tyrosine kinase inhibitor",-0.39451,-1.05,0.336,1372,0.862,"dasatinib, CP.724714, vandetanib, BMS.599626, AV.412",0.473660722610156,0.0644927341752872,FALSE +"proteomics","Pearson.est","VEGFR inhibitor",-0.28031,-0.734,0.777,1391,0.992,"AEE788, vandetanib, ZM.306416, XL.647, BMS.690514",0.109578981199086,0.00348832784582135,FALSE +"proteomics","Pearson.est","vitamin D receptor agonist",-0.86287,-2.3,0,1252,0.00102,"alfacalcidol, ercalcitriol, calcitriol, tacalcitol, paricalcitol, maxacalcitol",Inf,2.99139982823808,TRUE +"metabolomics","Pearson.est","EGFR inhibitor",-0.63456,-1.75,0.0273,1223,0.578,"ARRY.334543, BMS.690514, WZ8040, PD.153035, BIBU.1361, salvianolic.acid.B, tyrphostin.AG.494, canertinib, erlotinib, OSI.420, afatinib, GW.583340, neratinib, rociletinib, AZD8931, TAK.285, XL.647, osimertinib, dacomitinib, icotinib, AEE788, gefitinib, pelitinib, vandetanib",1.56383735295924,0.238072161579471,FALSE +"metabolomics","Pearson.est","Abl kinase inhibitor",-0.4422,-1.2,0.25,1285,0.587,"tozasertib, ponatinib, dasatinib",0.602059991327962,0.231361898752386,FALSE +"metabolomics","Pearson.est","acetylcholine receptor agonist",0.53901,1.29,0.193,360,0.671,"pilocarpine, xanomeline, oxiracetam, nefiracetam",0.714442690992226,0.173277479831008,FALSE +"metabolomics","Pearson.est","acetylcholine receptor antagonist",-0.27739,-0.764,0.725,400,0.862,"hyoscyamine, darifenacin, diphemanil, methscopolamine, iododexetimide, dicycloverine",0.139661993429006,0.0644927341752872,FALSE +"metabolomics","Pearson.est","adenosine receptor antagonist",-0.31228,-0.822,0.673,450,0.922,"PSB.1115, theophylline, MRS.1220, sulmazole, SCH.58261, istradefylline, CGS.15943",0.171984935776023,0.0352690789463706,FALSE +"metabolomics","Pearson.est","adrenergic receptor agonist",0.21517,0.522,0.971,477,1,"lidamidine, buphenine, xylazine, midodrine, methyldopa",0.0127807700919951,0,FALSE +"metabolomics","Pearson.est","adrenergic receptor antagonist",0.45723,1.1,0.345,194,0.794,"prazosin, naftidrofuryl, RS.17053, imiloxan",0.462180904926726,0.100179497572904,FALSE +"metabolomics","Pearson.est","AKT inhibitor",-0.27557,-0.717,0.774,396,0.826,"AT7867, AZD5363, GSK2110183, CCT128930, GDC.0068, ONC201, palomid.529, A.674563, uprosertib, triciribine, MK.2206",0.111259039317107,0.0830199526796178,FALSE +"metabolomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.45618,-1.23,0.201,1097,0.577,"DMH1, AP26113, brigatinib, crizotinib, GW.788388, AZD3463, CEP.37440",0.696803942579511,0.238824186844269,FALSE +"metabolomics","Pearson.est","androgen receptor antagonist",0.35855,0.868,0.615,121,0.998,"flutamide",0.211124884224583,0.000869458712628891,FALSE +"metabolomics","Pearson.est","antioxidant",-0.33148,-0.913,0.545,478,0.853,"rutin, benfotiamine, mesna, trolox, taurine, chlorogenic.acid",0.263603497723358,0.069050968832477,FALSE +"metabolomics","Pearson.est","AP inhibitor",0.53974,1.28,0.182,606,0.647,"tanshinone.i, GDC.0152, birinapant, LCL.161",0.739928612014925,0.1890957193313,FALSE +"metabolomics","Pearson.est","ATPase inhibitor",0.42939,1.04,0.422,68,0.762,"oligomycin.a, NMS.873",0.374687549038326,0.1180450286604,FALSE +"metabolomics","Pearson.est","Aurora kinase inhibitor",0.61922,1.5,0.0567,120,0.803,"PHA.680632, AT.9283, barasertib.HQPA, danusertib, CCT129202, SNS.314, GSK1070916, TAK.901, ZM.447439, alisertib",1.24641694110709,0.095284454721319,FALSE +"metabolomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.42133,-1.14,0.297,1397,0.582,"dirithromycin, azithromycin",0.527243550682788,0.235077015350112,FALSE +"metabolomics","Pearson.est","bacterial DNA gyrase inhibitor",0.28297,0.691,0.82,57,1,"norfloxacin",0.0861861476162833,0,FALSE +"metabolomics","Pearson.est","BCL inhibitor",-0.55553,-1.53,0.0683,1217,0.399,"obatoclax, navitoclax, TW.37, HA14.1, gossypol",1.16557929631847,0.399027104313252,FALSE +"metabolomics","Pearson.est","Bcr.Abl kinase inhibitor",-0.51582,-1.41,0.137,1285,0.427,"tozasertib, ponatinib, dasatinib",0.863279432843593,0.369572124974976,FALSE +"metabolomics","Pearson.est","benzodiazepine receptor agonist",0.5082,1.22,0.243,407,0.665,"ZK.93423, bentazepam, gamma.aminobutyric.acid, indiplon, nefiracetam, lorazepam",0.614393726401688,0.177178354696895,FALSE +"metabolomics","Pearson.est","bromodomain inhibitor",0.59722,1.43,0.104,583,0.779,"I.BET151, OTX015, I.BET.762, JQ1...., PFI.1",0.98296666070122,0.108462542327436,FALSE +"metabolomics","Pearson.est","calcium channel blocker",0.37974,0.908,0.58,514,0.948,"fendiline, efonidipine.monoethanolate, pranidipine, cinnarazine, SR.33805, carboxyamidotriazole",0.236572006437063,0.0231916626619338,FALSE +"metabolomics","Pearson.est","CC chemokine receptor antagonist",0.27693,0.682,0.841,282,1,"SB.225002, ZK811752",0.0752040042020878,0,FALSE +"metabolomics","Pearson.est","CDK inhibitor",0.24473,0.58,0.963,423,1,"PHA.793887, R547, ribociclib, CR8..R., JNJ.7706621, arcyriaflavin.a, BMS.387032",0.0163737128754655,0,FALSE +"metabolomics","Pearson.est","CHK inhibitor",-0.635,-1.73,0.0356,1338,0.423,"LY2603618, LY2606368, SCH.900776",1.44855000202712,0.373659632624958,FALSE +"metabolomics","Pearson.est","cyclooxygenase inhibitor",0.28761,0.693,0.841,474,1,"naproxen, AM.404, piroxicam, metoxibutropate, FR.122047, aspirin, acetylsalicylsalicylic.acid, FK.3311",0.0752040042020878,0,FALSE +"metabolomics","Pearson.est","cytochrome P450 inhibitor",-0.2823,-0.758,0.731,1227,0.844,"eplerenone, itraconazole",0.13608262304214,0.073657553374345,FALSE +"metabolomics","Pearson.est","DNA alkylating agent",0.20883,0.505,0.969,531,0.998,"carboplatin, TH.302, dianhydrogalactitol, mitomycin.c, satraplatin, streptozotocin",0.0136762229492347,0.000869458712628891,FALSE +"metabolomics","Pearson.est","DNA inhibitor",0.39273,0.941,0.539,332,0.946,"tirapazamine, busulfan, oxaliplatin, carboplatin, valrubicin, primaquine",0.268411234813261,0.0241088635982073,FALSE +"metabolomics","Pearson.est","DNA methyltransferase inhibitor",-0.4181,-1.08,0.322,1373,0.622,"azacitidine, decitabine",0.492144128304169,0.206209615309181,FALSE +"metabolomics","Pearson.est","DNA polymerase inhibitor",0.43964,1.05,0.393,326,0.771,"cephalomannine, famciclovir, trifluridine",0.405607449624573,0.112945621949043,FALSE +"metabolomics","Pearson.est","DNA synthesis inhibitor",0.34522,0.831,0.687,179,1,"artemisinin, floxuridine",0.16304326294045,0,FALSE +"metabolomics","Pearson.est","dopamine receptor antagonist",0.38897,0.938,0.562,507,0.919,"UH.232...., isofloxythepin, clebopride, lurasidone, domperidone, thioproperazine, remoxipride, oxiperomide, ziprasidone",0.250263684430939,0.0366844886138887,FALSE +"metabolomics","Pearson.est","estrogen receptor agonist",-0.29501,-0.807,0.66,1420,0.882,"estradiol",0.180456064458131,0.0545314148681803,FALSE +"metabolomics","Pearson.est","estrogen receptor antagonist",0.58977,1.43,0.094,460,0.779,"tamoxifen, raloxifene, clomifene, danazol",1.0268721464003,0.108462542327436,FALSE +"metabolomics","Pearson.est","FGFR inhibitor",-0.58144,-1.53,0.105,1252,0.399,"MK.2461, lucitanib, regorafenib, erdafitinib",0.978810700930062,0.399027104313252,FALSE +"metabolomics","Pearson.est","FLT3 inhibitor",-0.28639,-0.738,0.753,1119,0.822,"sorafenib, KW.2449, gilteritinib, sunitinib, pacritinib, tozasertib, ponatinib",0.123205023799299,0.0851281824599496,FALSE +"metabolomics","Pearson.est","glucocorticoid receptor agonist",0.48681,1.21,0.243,582,0.617,"hydrocortisone, prednisolone, halcinonide, fluticasone.propionate, flumethasone.pivalate, dexamethasone.acetate, piretanide, fluorometholone, betamethasone, rimexolone, halobetasol.propionate, triamcinolone, deflazacort, fludroxycortide, clobetasol.propionate, methylprednisolone, ciclesonide",0.614393726401688,0.209714835966758,FALSE +"metabolomics","Pearson.est","glutamate receptor antagonist",0.49974,1.23,0.236,421,0.728,"IEM1754, ACDPP, CPP, latrepirdine, felbamate, tiletamine, LY456236",0.627087997029893,0.137868620686963,FALSE +"metabolomics","Pearson.est","glycogen synthase kinase inhibitor",0.28641,0.69,0.854,438,1,"CHIR.99021, CHIR.98014, TWS.119",0.068542129310995,0,FALSE +"metabolomics","Pearson.est","growth factor receptor inhibitor",0.43831,1.07,0.381,45,0.791,"danusertib, GW.441756",0.419075024324381,0.101823516502323,FALSE +"metabolomics","Pearson.est","HCV inhibitor",-0.4941,-1.29,0.191,1435,0.523,"Ro.9187",0.718966632752272,0.281498311132726,FALSE +"metabolomics","Pearson.est","HDAC inhibitor",-0.57556,-1.54,0.0667,1201,0.541,"belinostat, givinostat, M.344, AR.42, chidamide, PCI.24781, entinostat, tacedinaline, dacinostat, panobinostat, resminostat, R306465, RG2833",1.17587416608345,0.266802734893431,FALSE +"metabolomics","Pearson.est","histamine receptor antagonist",0.34081,0.827,0.655,223,1,"levocetirizine, terfenadine, ICI.162846, epinastine",0.183758700008217,0,FALSE +"metabolomics","Pearson.est","HMGCR inhibitor",0.62652,1.53,0.0604,113,0.902,"fluvastatin, mevastatin",1.21896306137887,0.0447934624580583,FALSE +"metabolomics","Pearson.est","HSP inhibitor",-0.31065,-0.831,0.68,1359,0.941,"BIIB021, NVP.AUY922, ganetespib",0.167491087293764,0.0264103765727431,FALSE +"metabolomics","Pearson.est","JAK inhibitor",0.2706,0.658,0.871,325,1,"AT.9283, WHI.P154, filgotinib, TG.101348, AZ960",0.0599818449923368,0,FALSE +"metabolomics","Pearson.est","KIT inhibitor",-0.35814,-0.955,0.468,1096,0.801,"pazopanib, motesanib, sorafenib, sunitinib, regorafenib, telatinib, dasatinib",0.329754146925876,0.0963674839157623,FALSE +"metabolomics","Pearson.est","MDM inhibitor",0.80779,1.95,0.00144,46,0.0788,"idasanutlin, CGM097, nutlin.3, AMG.232",2.84163750790475,1.10347378251044,TRUE +"metabolomics","Pearson.est","MEK inhibitor",-0.41557,-1.13,0.289,1278,0.566,"selumetinib, AZD8330, PD.184352, AS.703026, trametinib, cobimetinib, nobiletin",0.539102157243452,0.247183568811729,FALSE +"metabolomics","Pearson.est","MET inhibitor",-0.75175,-2.02,0.00338,1243,0.244,"INC.280, NVP.BVU972, PHA.665752, LY2801653",2.47108329972235,0.612610173661271,TRUE +"metabolomics","Pearson.est","microtubule inhibitor",0.57668,1.4,0.104,454,0.599,"cabazitaxel, colchicine, D.64131, podophyllotoxin, triclabendazole, vinblastine, secnidazole",0.98296666070122,0.222573177610689,FALSE +"metabolomics","Pearson.est","mTOR inhibitor",0.1635,0.396,0.994,231,0.998,"PF.05212384, PKI.179, AZD8055, LY303511",0.00261361560268669,0.000869458712628891,FALSE +"metabolomics","Pearson.est","NFkB pathway inhibitor",0.54292,1.31,0.191,148,0.671,"EVP4593, IKK.2.inhibitor.V, bindarit, parthenolide....",0.718966632752272,0.173277479831008,FALSE +"metabolomics","Pearson.est","opioid receptor agonist",0.30739,0.741,0.761,196,1,"spiradoline",0.118615343229427,0,FALSE +"metabolomics","Pearson.est","p38 MAPK inhibitor",0.58567,1.41,0.112,589,0.641,"CMPD.1, skepinone.l, SB.239063, SB.242235, VX.702, TAK.715",0.950781977329818,0.193141970481183,FALSE +"metabolomics","Pearson.est","PARP inhibitor",0.44842,1.09,0.353,530,0.78,"AG.14361, PJ.34, AZD2461, niraparib",0.452225294612177,0.10790539730952,FALSE +"metabolomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.43626,-1.18,0.232,1096,0.582,"pazopanib, motesanib, sorafenib, crenolanib, sunitinib, CP.673451, regorafenib, telatinib, ponatinib, dasatinib",0.6345120151091,0.235077015350112,FALSE +"metabolomics","Pearson.est","phosphatase inhibitor",-0.3753,-0.993,0.444,1211,0.758,"alexidine, mycophenolic.acid, BVT.948",0.35261702988538,0.120330794367946,FALSE +"metabolomics","Pearson.est","phosphodiesterase inhibitor",-0.33828,-0.895,0.535,1444,0.852,"YM.976",0.271646217978772,0.0695604052332999,FALSE +"metabolomics","Pearson.est","PI3K inhibitor",-0.29869,-0.8,0.664,1358,0.862,"alpelisib, CH5132799, GDC.0980, PI3K.IN.2, TG100.115",0.177831920631982,0.0644927341752872,FALSE +"metabolomics","Pearson.est","PLK inhibitor",0.55657,1.35,0.142,259,0.68,"HMN.214, NMS.1286937, GW.843682X",0.847711655616944,0.167491087293764,FALSE +"metabolomics","Pearson.est","potassium channel blocker",-0.27809,-0.756,0.775,401,0.821,"ML133, meglitinide, dofetilide, oleoylethanolamide, ibutilide, mepivacaine",0.11069829749369,0.0856568428805592,FALSE +"metabolomics","Pearson.est","PPAR receptor agonist",0.43598,1.05,0.419,560,0.771,"GW.501516, ciprofibrate, S26948",0.377785977033705,0.112945621949043,FALSE +"metabolomics","Pearson.est","progesterone receptor agonist",0.49977,1.21,0.249,460,0.617,"tanaproget, norethindrone, danazol",0.603800652904264,0.209714835966758,FALSE +"metabolomics","Pearson.est","proteasome inhibitor",0.25747,0.626,0.918,599,1,"MG.132, delanzomib, ixazomib.citrate, ixazomib",0.0371573187987575,0,FALSE +"metabolomics","Pearson.est","protein synthesis inhibitor",0.47812,1.14,0.326,132,0.738,"puromycin, bruceantin, harringtonine, azomycin..2.nitroimidazole., cycloheximide, clofoctol",0.486782399932061,0.131943638176958,FALSE +"metabolomics","Pearson.est","protein tyrosine kinase inhibitor",0.25261,0.618,0.897,111,1,"mubritinib",0.0472075569559079,0,FALSE +"metabolomics","Pearson.est","RAF inhibitor",0.2862,0.702,0.825,471,1,"PLX.4720, CEP.32496, LGX818, vemurafenib",0.0835460514500749,0,FALSE +"metabolomics","Pearson.est","RET tyrosine kinase inhibitor",-0.52342,-1.43,0.11,1119,0.442,"sorafenib, sunitinib, regorafenib, vandetanib",0.958607314841775,0.354577730650908,FALSE +"metabolomics","Pearson.est","retinoid receptor agonist",-0.55345,-1.47,0.0967,1306,0.431,"AM.580, tamibarotene, fenretinide, adarotene",1.014573525917,0.365522729839268,FALSE +"metabolomics","Pearson.est","ribonucleotide reductase inhibitor",-0.28892,-0.798,0.719,1333,0.836,"fludarabine, hydroxyurea",0.143271109617117,0.0777937225609836,FALSE +"metabolomics","Pearson.est","serotonin receptor agonist",0.32517,0.809,0.699,336,1,"aripiprazole, ipsapirone",0.155522824254319,0,FALSE +"metabolomics","Pearson.est","serotonin receptor antagonist",0.2685,0.657,0.881,587,1,"aripiprazole, lurasidone, pirenperone, ziprasidone, RS.16566, sertindole",0.0550240915879521,0,FALSE +"metabolomics","Pearson.est","sodium channel blocker",0.49388,1.22,0.243,256,0.665,"benzocaine, benzethonium, mexiletine, A.803467, oxcarbazepine",0.614393726401688,0.177178354696895,FALSE +"metabolomics","Pearson.est","src inhibitor",-0.47531,-1.31,0.169,1266,0.537,"PP.2, saracatinib, PP.1, dasatinib",0.772113295386326,0.270025714300444,FALSE +"metabolomics","Pearson.est","sterol demethylase inhibitor",0.58447,1.41,0.117,431,0.641,"chlormidazole, posaconazole, sulconazole, lanoconazole",0.931814138253838,0.193141970481183,FALSE +"metabolomics","Pearson.est","TGF beta receptor inhibitor",0.55805,1.33,0.156,4,0.674,"SB.525334",0.806875401645538,0.17134010346468,FALSE +"metabolomics","Pearson.est","thymidylate synthase inhibitor",-0.22538,-0.604,0.934,325,0.925,"trifluridine, capecitabine, raltitrexed, carmofur, doxifluridine, ftorafur",0.0296531237699066,0.0338582672609674,FALSE +"metabolomics","Pearson.est","topoisomerase inhibitor",0.23305,0.564,0.953,535,1,"TAS.103, voreloxin, amonafide, teniposide, mitoxantrone, valrubicin, dexrazoxane, etoposide, amsacrine, SN.38, camptothecin, etoposide.phosphate",0.0209070993616736,0,FALSE +"metabolomics","Pearson.est","tubulin polymerization inhibitor",0.68532,1.65,0.0269,272,0.625,"ABT.751, epothilone.b, vincristine, flubendazole, dolastatin.10, indibulin, CYT.997, KX2.391, oxibendazole, parbendazole, plinabulin, nocodazole, mebendazole, taltobulin, vinorelbine, podophyllotoxin, combretastatin.A.4, verubulin",1.57024771999759,0.204119982655925,FALSE +"metabolomics","Pearson.est","tyrosine kinase inhibitor",-0.30407,-0.813,0.675,1108,0.905,"AV.412, bafetinib, sorafenib, BMS.599626, aminopurvalanol.a, sunitinib, regorafenib, tivantinib, NVP.TAE226, dasatinib, vandetanib",0.170696227168975,0.0433514207947967,FALSE +"metabolomics","Pearson.est","VEGFR inhibitor",-0.42573,-1.16,0.27,1096,0.582,"pazopanib, semaxanib, motesanib, sorafenib, golvatinib, sunitinib, BMS.690514, MK.2461, lucitanib, regorafenib, XL.647, AEE788, foretinib, telatinib, vandetanib",0.568636235841013,0.235077015350112,FALSE +"metabolomics","Pearson.est","vitamin D receptor agonist",-0.61198,-1.61,0.0762,1208,0.519,"calcitriol, maxacalcitol, tacalcitol",1.1180450286604,0.284832642151542,FALSE diff --git a/Examples/Fig3/DMEA/DMEA_venn_diagram.pdf b/Examples/Fig3/DMEA/DMEA_venn_diagram.pdf new file mode 100644 index 0000000000000000000000000000000000000000..33fa4979f6511e9433f9a1aa5a22ddf6804909f0 GIT binary patch literal 6485 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proteomics",2,0,"",0.6716701443558 +"KEGG_SPLICEOSOME",-1.123,0.207889393668845,0.247044448640774,"transcriptomics, proteomics",2,0,"",0.666271391788755 +"KEGG_ASTHMA",-1.23,NA,NA,"transcriptomics",1,0,"",NA +"KEGG_BASAL_TRANSCRIPTION_FACTORS",-1.27,0.0707106781186548,0.113393462978043,"transcriptomics, proteomics",2,0,"",0.545819606787798 +"KEGG_RNA_POLYMERASE",-1.28,0.0565685424949239,0.113456884557014,"transcriptomics, proteomics",2,0,"",0.545819606787798 +"KEGG_RNA_DEGRADATION",-1.29,0,0.104613702332317,"transcriptomics, proteomics",2,0,"",0.545819606787798 +"acyl carnitines",-1.41,NA,NA,"metabolomics",1,0,"",NA +"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-1.458,0.667508801440101,0.0261380103230906,"transcriptomics, proteomics",2,1,"transcriptomics",0.37623265403939 +"alpha amino acids",-1.46,NA,NA,"metabolomics",1,0,"",NA +"KEGG_RIBOSOME",-1.47,0.212132034355964,0.039588851420882,"transcriptomics, proteomics",2,0,"",0.425285555316793 +"KEGG_AUTOIMMUNE_THYROID_DISEASE",-1.48,NA,NA,"transcriptomics",1,0,"",NA +"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-1.55,0.636396103067893,0.0378256367861026,"transcriptomics, proteomics",2,0,"",0.425285555316793 +"KEGG_ONE_CARBON_POOL_BY_FOLATE",-1.56,0.014142135623731,0.0233911092742783,"transcriptomics, proteomics",2,0,"",0.37623265403939 +"KEGG_LIMONENE_AND_PINENE_DEGRADATION",-1.74,0.325269119345812,0.00452156107133286,"transcriptomics, proteomics",2,0,"",0.114976838671036 +"KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-1.82,0.014142135623731,0.00239320808077857,"transcriptomics, proteomics",2,1,"transcriptomics",0.109264699548369 +"KEGG_NON_HOMOLOGOUS_END_JOINING",-2.055,0.106066017177982,0.000526791429272389,"transcriptomics, proteomics",2,2,"transcriptomics, proteomics",0.0468844372052426 diff --git a/Examples/Fig3/GSEA/GSEA_results.csv b/Examples/Fig3/GSEA/GSEA_results.csv new file mode 100644 index 0000000..5ee06fe --- /dev/null +++ b/Examples/Fig3/GSEA/GSEA_results.csv @@ -0,0 +1,370 @@ +"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"transcriptomics","Log2FC","KEGG_ABC_TRANSPORTERS",0.23561,0.683,0.935,7191,0.996,"ABCA12, ABCB8, ABCB9, ABCA13, ABCD1, ABCC3, ABCA1, ABCA2, ABCB11, ABCC10, ABCD4, ABCA4, ABCC5, ABCA5, TAP2, ABCC11, ABCG1, ABCB6, ABCG2",0.0291883891274822,0.00174066157630127,FALSE +"transcriptomics","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.36169,1.04,0.384,5916,0.764,"PIK3R2, IKBKB, MAPK3, RPS6KB2, PML, RARA, PIK3CA, JUP, STAT5B, STAT3, BRAF, RELA, TCF7L1, RUNX1, BAD, PIM1, PIK3R3, CCNA1, STAT5A, MAPK1, PIK3R5, PIK3CB, CEBPA",0.415668775632469,0.11690664142431,FALSE +"transcriptomics","Log2FC","KEGG_ADHERENS_JUNCTION",0.36058,1.04,0.371,3562,0.764,"NECTIN1, CTNND1, CDH1, ERBB2, BAIAP2, NECTIN4, PTPN1, RAC2, MAPK3, INSR, PTPN6, SNAI2, MET, IGF1R, EP300, EGFR, PTPRF, TCF7L1, PTPRB, SRC",0.430626090384954,0.11690664142431,FALSE +"transcriptomics","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.27558,0.808,0.762,5975,1,"TRADD, RXRA, CPT1B, PPARA, IKBKB, ACSL1, RXRB, CPT1C, ADIPOR1, IRS2, STAT3, PRKAA1, RELA, ACSL3, PRKAG2, PRKAB2, ACSL5, ACSL6, SLC2A1, MAPK10, IRS1, NFKBIA",0.1180450286604,0,FALSE +"transcriptomics","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.44972,1.3,0.117,3496,0.803,"GLUL, AGXT, GLS2, ASL, ABAT, ASS1, GPT, NIT2, IL4I1",0.931814138253838,0.095284454721319,FALSE +"transcriptomics","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.37286,1.08,0.321,5894,0.75,"PIK3R2, SCNN1A, MAPK3, INSR, PIK3CA, SFN, SCNN1G, IRS2, NEDD4L, PIK3R3, SCNN1B, HSD11B2, MAPK1, PIK3R5, IRS1, PIK3CB",0.493494967595128,0.1249387366083,FALSE +"transcriptomics","Log2FC","KEGG_ALLOGRAFT_REJECTION",-0.23407,-0.835,0.759,16990,0.98,"PRF1, IL5",0.11975822410452,0.00877392430750515,FALSE +"transcriptomics","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.40981,1.19,0.192,3971,0.704,"PLA2G12A, PLA2G6, PLA2G4B, PLA2G10, PLA2G4E, ACOX1, PLA2G2C",0.71669877129645,0.152427340857888,FALSE +"transcriptomics","Log2FC","KEGG_ALZHEIMERS_DISEASE",0.24418,0.709,0.907,6624,1,"NDUFV1, CAPN1, CACNA1D, GRIN1, ATP2A3, CALML3, COX5B, LRP1, ATP5F1E, NDUFB7, MAPK3, CDK5, FADD, NDUFS8, EIF2AK3, NDUFA3, NDUFV2, COX6C, UQCR10, GRIN2A, APH1A, COX6B2, GRIN2D, CHP1, PPP3CA, SDHD, ADAM10, BAD, UQCR11, GNAQ, NDUFB4, NDUFAB1, APOE, CALML6, UQCRB, BACE2, NDUFA6, UQCRHL, ITPR3, NDUFA5, UQCRC1, NDUFB5, BID, MAPK1, CACNA1F, UQCRFS1, UQCRC2, PLCB3, COX6A1, GSK3B, NDUFA2, SNCA, APP, ERN1, CAPN2, ATP5PD, GRIN2C, NOS1, CHP2",0.0423927129399047,0,FALSE +"transcriptomics","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.55987,-2,0.0202,17343,0.292,"IARS2, MARS2, FARS2, FARSB, WARS2, RARS2, PSTK, YARS2",1.69464863055338,0.534617148551582,FALSE +"transcriptomics","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.51252,1.48,0.046,5085,0.531,"HK2, MPI, GMPPA, NANP, GCK, PGM1, GMPPB, NPL, NAGK, GALT, CYB5R1, NANS, FPGT, HK1, GALE, UXS1, CYB5R3, HEXB, GNPDA1, AMDHD2, PGM2",1.33724216831843,0.274905478918531,FALSE +"transcriptomics","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.28452,0.827,0.746,4515,0.993,"CAT, CCS, CASP1, MAPK13, GRIN1, GRIN2A, GPX1, GRIN2D, CHP1, MAPK11, PPP3CA, BAD, MAP3K5",0.127261172527331,0.00305075150461883,FALSE +"transcriptomics","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.26803,0.771,0.824,4719,1,"RFXANK, IFI30, TAPBP, CALR, CD74, CTSS, LGMN, CTSB, HSPA1B, B2M, CIITA, PDIA3, PSME1, CD4",0.0840727883028842,0,FALSE +"transcriptomics","Log2FC","KEGG_APOPTOSIS",0.28433,0.815,0.76,6624,1,"TRADD, IL1RAP, CAPN1, PIK3R2, ENDOD1, IKBKB, PIK3CA, MYD88, FADD, TNFSF10, CASP10, RELA, CHP1, PPP3CA, IRAK4, BAD, ENDOG, PIK3R3, NGF, PRKACA, IL1A, BID, CSF2RB, BAX, PIK3R5, PIK3CB, IL1R1, NFKBIA, PRKAR1B, DFFA, CAPN2, BCL2L1, CHP2",0.119186407719209,0,FALSE +"transcriptomics","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",0.38876,1.13,0.26,2694,0.706,"PLA2G12A, CYP4F3, CYP2E1, PTGES, PLA2G6, GGT7, PLA2G4B, LTC4S, PTGES2, EPHX2, CYP2J2, CYP4A22, PTGS1, PLA2G10, PLA2G4E, ALOX12B",0.585026652029182,0.151195298948196,FALSE +"transcriptomics","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.31866,0.924,0.581,5717,0.961,"GLUL, PYCR3, CKMT1A, CKMT1B, SAT2, NOS3, GLS2, ASL, ASS1, OAT, GATM, P4HA2, NAGS, PRODH, P4HA1, MAOA, AZIN2, ALDH4A1, GAMT",0.235823867609669,0.0172766123314547,FALSE +"transcriptomics","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.3651,1.06,0.368,3482,0.757,"ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, JUP, DSP, ITGA3, CACNB2, DAG1, DSG2, ITGA2B, DSC2, TCF7L1, PKP2",0.434152181326482,0.120904120499927,FALSE +"transcriptomics","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.50501,-1.81,0.0118,14596,0.146,"UGDH, MIOX, ALDH3A2, UGT2A1, ALDH1B1, ALDH7A1, ALDH9A1",1.92811799269387,0.835647144215563,TRUE +"transcriptomics","Log2FC","KEGG_ASTHMA",-0.34369,-1.23,0.17,17122,0.467,"IL13, EPX, IL5",0.769551078621726,0.330683119433888,FALSE +"transcriptomics","Log2FC","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.42092,-1.48,0.0396,16806,0.293,"IFNA21, PRF1, IFNA13, IL5, CTLA4",1.40230481407449,0.533132379645891,FALSE +"transcriptomics","Log2FC","KEGG_AXON_GUIDANCE",0.44776,1.29,0.124,5666,0.805,"EPHA1, PAK6, PLXNB2, EPHB3, PLXNB1, PLXNA3, SEMA4A, EFNA1, FES, SEMA3E, EFNA4, SEMA4B, RAC2, LIMK2, SEMA7A, EFNA3, SRGAP3, MAPK3, NTN4, RHOD, UNC5B, NTN1, PLXNB3, CDK5, EPHB4, MET, PLXNA2, EPHB6, SEMA3B, ABLIM3, NCK2, EPHB2, SEMA4F, SRGAP1, UNC5A, ABLIM2, EFNB3, EFNB1, ABLIM1, SEMA5B, CHP1, PPP3CA, PAK2, SEMA4C, SEMA4D, NGEF, SEMA3C, LIMK1, NCK1, SEMA5A, RASA1, RND1, ROBO3, RAC1, PAK1, PAK4, MAPK1, NFATC1",0.906578314837765,0.0942041196321315,FALSE +"transcriptomics","Log2FC","KEGG_BASAL_CELL_CARCINOMA",0.3741,1.08,0.318,4115,0.75,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, WNT4, DVL3, BMP2, WNT10A, GLI3, TCF7L1, FZD4, DVL2, WNT11",0.497572880015567,0.1249387366083,FALSE +"transcriptomics","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.36638,-1.32,0.112,18395,0.384,"TBPL1, TAF9B, TBP, GTF2H2, TAF9, TAF1L",0.950781977329818,0.415668775632469,FALSE +"transcriptomics","Log2FC","KEGG_BASE_EXCISION_REPAIR",0.30931,0.89,0.646,912,0.974,"SMUG1, POLD4, POLB",0.189767482004916,0.0114410431213845,FALSE +"transcriptomics","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.24897,-0.895,0.577,17472,0.879,"ALDH1B1, ALDH7A1, SMS, ALDH9A1",0.238824186844269,0.0560111249262281,FALSE +"transcriptomics","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.30636,0.885,0.645,3986,0.967,"ACOT4, TECR, ACAA1, ELOVL6, ACOX1, SCD5",0.190440285364732,0.0145735259169983,FALSE +"transcriptomics","Log2FC","KEGG_BLADDER_CANCER",0.38783,1.12,0.262,4516,0.711,"CDH1, ERBB2, MMP9, TYMP, VEGFB, MAPK3, EGFR, E2F1, DAPK1, THBS1, FGFR3, BRAF, PGF, VEGFA, DAPK2",0.581698708680255,0.148130399270234,FALSE +"transcriptomics","Log2FC","KEGG_BUTANOATE_METABOLISM",0.28276,0.829,0.754,2472,1,"ABAT, HMGCL, BDH1, HMGCS1, ACADS, EHHADH",0.122628654130226,0,FALSE +"transcriptomics","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.39615,1.15,0.241,6959,0.71,"VAV1, BLNK, PIK3R2, PLCG2, DAPP1, RAC2, VAV3, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, IFITM1, CD72, CD79A, RELA, CD19, CHP1, PPP3CA, LYN, PIK3R3, RAC1, MAPK1, NFATC1, PIK3R5, PIK3AP1, PIK3CB, NFKBIA, GSK3B, FOS, SYK, NFATC4, GRB2, CHP2, INPP5D, BCL10, CD22",0.617982957425132,0.148741651280925,FALSE +"transcriptomics","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.29926,0.872,0.691,4406,0.982,"DRD5, PTAFR, BDKRB2, ERBB2, P2RX4, PLCG2, GNA15, CACNA1D, ERBB3, GRIN1, PLCD1, ATP2A3, CALML3, NOS3, CAMK2G, ADORA2B, ADORA2A, CACNA1I, ADCY4, BDKRB1, RYR1, PTK2B, EGFR, ATP2B4, SLC8A2, GRIN2A, PLCG1, SPHK2, PHKG1, ADRB2, GRIN2D, CHP1, P2RX6, PPP3CA, EDNRA, TNNC1, GNAS, GNAQ, P2RX2, LTB4R2, HTR7",0.160521952625802,0.00788851221305034,FALSE +"transcriptomics","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.27818,0.802,0.78,6162,1,"TNNI3, CACNA1D, CACNG1, COX5B, CACNB3, CACNG4, CACNB2, COX6C, UQCR10, COX6B2, TNNT2, TNNC1, SLC9A1, UQCR11, UQCRB, UQCRHL, UQCRC1, CACNA1F, UQCRFS1, UQCRC2, COX6A1",0.10790539730952,0,FALSE +"transcriptomics","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.37321,1.08,0.349,3535,0.75,"CDH3, NECTIN1, CDH1, CLDN8, ITGB2, CLDN9, CLDN7, CLDN4, F11R, ITGB8, CDH5, SDC1, ICOSLG, SDC4, CLDN18, ICAM3, CD6, GLG1, CLDN11, CD40, SELL, PTPRF, CLDN23, CD276, CLDN3",0.45717457304082,0.1249387366083,FALSE +"transcriptomics","Log2FC","KEGG_CELL_CYCLE",-0.36349,-1.32,0.108,15880,0.384,"ORC1, MCM4, PTTG2, CCNA2, ORC6, SMAD4, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, MCM3, ANAPC10, CDK6, CDC20, CDK1, SMC1A, CCNH, CCNB3, CDKN2C, CDC25A, TGFB1, ORC4, CCNB1, MCM6, PRKDC, TTK, CDC14A, CDKN2B, E2F2, BUB3, ORC2, CDC7, PTTG1, YWHAQ, HDAC2, SMC3, E2F5, ORC3, CDKN2A, E2F3, SMAD2, ANAPC13",0.96657624451305,0.415668775632469,FALSE +"transcriptomics","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.31904,0.917,0.585,4742,0.971,"CCR3, PRKCD, CCL22, STAT2, GRK7, VAV1, PIK3R2, FOXO3, GRK2, CX3CL1, RAC2, VAV3, CCL17, JAK3, CXCL10, IKBKB, MAPK3, CCL28, CCR2, ARRB1, VAV2, CCR7, ADCY5, PIK3CA, ADCY4, CXCL11, CXCL16, CCL5, PTK2B, STAT5B, RAP1A, CXCL9, CXCR2, STAT3, BRAF, ADCY6, RELA, TIAM1, PXN, GNB2, TIAM2, CCL26, CCL19, CXCL3, PRKCZ, CXCR6, WASL, LYN, PIK3R3, STAT1, CCR1",0.23284413391782,0.0127807700919951,FALSE +"transcriptomics","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.24297,0.706,0.907,6797,0.988,"CBLC, BCR, PIK3R2, IKBKB, MAPK3, PIK3CA, STAT5B, E2F1, CBLB, BRAF, CDKN1B, RELA, MECOM, RUNX1, BAD, PIK3R3, TGFB3, CRKL, STAT5A, TGFBR2, MAPK1, PIK3R5, PIK3CB, NFKBIA, CDKN1A, BCL2L1, GRB2, CTBP1, CCND1",0.0423927129399047,0.00524305541237188,FALSE +"transcriptomics","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.41491,1.21,0.174,4027,0.689,"BHLHE41, NR1D1, CSNK1E, BHLHE40, PER3",0.7594507517174,0.161780778092374,FALSE +"transcriptomics","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29489,0.855,0.718,7287,0.994,"PC, IDH2, ACO2, IDH3B, SDHD, OGDHL, MDH1, MDH2, OGDH, IDH3G, IDH1, SUCLG2, SDHA",0.1438755557577,0.00261361560268669,FALSE +"transcriptomics","Log2FC","KEGG_COLORECTAL_CANCER",-0.17873,-0.625,0.991,14592,1,"KRAS, RAF1, LEF1, CASP9, BIRC5, AKT2, MAPK9, BCL2, MSH6, CASP3, MSH3, RHOA, APPL1, APC2, AKT3, SMAD4, PIK3R1, PIK3CG, MSH2, APC, TGFB1, TCF7, MAPK8, AXIN2, SMAD2",0.00392634551472468,0,FALSE +"transcriptomics","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.26321,0.763,0.867,6969,0.992,"BDKRB2, F3, BDKRB1, VWF, FGA, FGG, CFB, PROC, C3, PLAU, CD59, SERPINA5, C2, PLAT, SERPINA1, C9, C1R, CFI, F8, CD55, C4A, SERPINF2, F12, FGB",0.0619809025237897,0.00348832784582135,FALSE +"transcriptomics","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.22246,-0.792,0.741,15262,1,"BHMT, ADI1, MTR, CDO1, GOT2, SRM, LDHB, MAT2A, AMD1, SMS, MTAP, TRDMT1",0.130181792020672,0,FALSE +"transcriptomics","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33412,0.969,0.504,5572,0.868,"CCR3, IFNL3, IFNL1, CSF1R, CCL22, TNFSF13, IFNL2, IL1RAP, CRLF2, TNFRSF21, PDGFA, IL9R, BMP7, CX3CL1, TNFRSF18, CCL17, IL4R, VEGFB, CXCL10, LTBR, CCL28, CCR2, IFNLR1, EPOR, IFNB1, PDGFB, BMP2, CCR7, FLT3LG, MET, CXCL11, CXCL16, CCL5, TNFRSF25, EGFR, CTF1, ACVR1B, IL18, CD40, IL12B, CXCL9, TNFSF10, CXCR2, TNFRSF14, CLCF1, IL7R, EPO, CCL26, IL20RB, IL6R, IL6, NGFR, CCL19, CXCL3, IL20RA, TNFSF18, CXCR6, VEGFA, CSF2, TNFRSF12A, IL15RA, CCR1, LTB, IL12A, IL1R2, PRLR, TGFB3, CSF1, GH2, OSMR, INHBB, IL1A, VEGFC, EDAR, IFNGR1, TGFBR2, CXCL6, IL17RA, CSF2RB",0.297569463554475,0.0614802748235081,FALSE +"transcriptomics","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.36654,1.06,0.345,3908,0.757,"CASP1, MAVS, RIPK3, IRF3, CXCL10, IKBKB, IFNB1, CCL5, DDX58, IL18, PYCARD, RELA, IKBKE, IL6",0.462180904926726,0.120904120499927,FALSE +"transcriptomics","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",0.30112,0.882,0.67,4386,0.966,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ADCY5, ADCY4, ITGA3, CACNB2, DAG1, ITGA2B, ADCY6, TNNT2, TNNC1, GNAS, ITGA2",0.173925197299174,0.0150228735845067,FALSE +"transcriptomics","Log2FC","KEGG_DNA_REPLICATION",-0.44719,-1.56,0.037,15778,0.326,"DNA2, RFC2, MCM4, RFC5, MCM3, RNASEH1, PRIM1, MCM6, RNASEH2B, PRIM2, POLE3, RFC1, RPA2, POLA1",1.431798275933,0.486782399932061,FALSE +"transcriptomics","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.4409,1.27,0.124,5751,0.753,"ETV7, ETS2, MAPK3, ETV6, EGFR, NOTCH3, PIWIL2, NOTCH1, MAPK1, SPIRE1, SPIRE2",0.906578314837765,0.123205023799299,FALSE +"transcriptomics","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.47037,1.36,0.0989,3662,0.73,"ADH7, ALDH3B2, GSTK1, CYP2E1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, FMO4, MGST2, CYP2D6, UGT2B17, MGST3",1.00480370840282,0.136677139879544,FALSE +"transcriptomics","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.40437,1.17,0.243,3623,0.721,"XDH, TYMP, NAT1, UCKL1, CES2, UPP1, TK1, CDA, UGT2B17, TPMT, GUSB, ITPA",0.614393726401688,0.142064735280571,FALSE +"transcriptomics","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.39479,1.15,0.222,4629,0.71,"CHAD, LAMA3, ITGB6, LAMB3, ITGB8, SDC1, SDC4, CD47, TNC, LAMC2, GP6, ITGB4, CD44, AGRN, THBS3, VWF, ITGA3, DAG1, THBS1, ITGA2B, COL1A1, LAMA5, LAMB1, ITGA2, COL5A1, HSPG2",0.653647025549361,0.148741651280925,FALSE +"transcriptomics","Log2FC","KEGG_ENDOCYTOSIS",0.41396,1.19,0.207,5701,0.704,"EPN3, CHMP4B, CBLC, PSD4, CSF1R, ITCH, TRAF6, RAB11FIP4, CHMP2B, GRK7, FGFR2, RAB22A, PLD1, ARFGAP1, CHMP2A, GRK2, RAB5B, ARAP1, ERBB3, TFRC, ACAP1, EHD2, PLD2, SMURF1, VPS37C, ARRB1, CHMP5, PRKCI, CHMP3, RAB11FIP1, MET, MVB12A, SH3GLB2, IGF1R, CHMP6, VPS28, ARAP2, PARD6B, EGFR, EPN1, ARFGAP3, VPS37B, FGFR3, LDLRAP1, CXCR2, ARFGAP2, CBLB, EPS15, AP2M1, ADRB2, SRC, HSPA1B, CHMP4C, RAB11FIP5, AGAP1, ACAP2, PRKCZ, AP2A1, NEDD4L, ARAP3, PIP5K1C, STAMBP, CHMP1B, LDLR, ASAP2, HSPA2, IQSEC1, DNM2, RAB11B, RAB31, ARF6, RAB5C, VPS25, STAM2",0.684029654543082,0.152427340857888,FALSE +"transcriptomics","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.26466,0.768,0.838,3392,1,"CDH1, ERBB2, PIK3R2, FOXO3, MAPK3, PIK3CA, EGFR, BRAF, TCF7L1",0.0767559813697235,0,FALSE +"transcriptomics","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.38362,1.1,0.284,6354,0.735,"MAPK13, PLCG2, F11R, ATP6V1C2, ATP6V0D2, ATP6V1B1, ATP6V1F, IKBKB, MET, CCL5, EGFR, ATP6AP1, CXCR2, PLCG1, RELA, SRC, MAPK11, NOD1, ADAM10, TCIRG1, LYN, ATP6V1G1, ATP6V0A4, RAC1, PAK1, MAPK10, ATP6V1C1, NFKBIA, TJP1, ATP6V1E1, IGSF5",0.546681659952962,0.133712660915805,FALSE +"transcriptomics","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.39525,1.14,0.249,5894,0.714,"GAB1, PAK6, CBLC, ERBB2, PIK3R2, PLCG2, ERBB3, CAMK2G, MAPK3, RPS6KB2, PIK3CA, NCK2, EGFR, STAT5B, BTC, CBLB, BRAF, PLCG1, CDKN1B, SRC, TGFA, PAK2, AREG, BAD, PIK3R3, NCK1, CRKL, STAT5A, PAK1, PAK4, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB",0.603800652904264,0.146301788223826,FALSE +"transcriptomics","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.38786,1.12,0.268,3971,0.711,"PLA2G12A, PLD1, PLA2G6, PLA2G4B, PLD2, LPCAT2, PLA2G10, PLA2G4E, PLPP3, LPCAT4, PLA2G2C",0.571865205971211,0.148130399270234,FALSE +"transcriptomics","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.38078,1.11,0.277,3627,0.717,"ADH7, ACAA1, CPT1B, GCDH, CYP4A22, ACSL1, CPT2, CPT1C, ACADS, EHHADH, ACOX1, ACSL3",0.557520230935551,0.1444808443322,FALSE +"transcriptomics","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.33886,0.98,0.475,2596,0.866,"PRKCD, PLA2G12A, VAV1, MAPK13, PIK3R2, PLCG2, RAC2, VAV3, PLA2G6, PLA2G4B, MAPK3, VAV2, PIK3CA, PLA2G10, PLA2G4E",0.323306390375133,0.0624821079826534,FALSE +"transcriptomics","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.40295,1.18,0.204,5894,0.703,"PRKCD, VAV1, PLD1, PIK3R2, PLCG2, RAC2, VAV3, LIMK2, PLA2G6, PLA2G4B, PLA2G4F, PLD2, MAPK3, RPS6KB2, VAV2, MARCKS, GSN, PIK3CA, PLA2G4E, PLCG1, PLPP3, SPHK2, WASL, LYN, PIK3R3, PIP5K1C, SPHK1, LIMK1, CRKL, SCIN, ASAP2, MYO10, DNM2, RAC1, PAK1, ARF6, MAPK1, PIK3R5, PIK3CB",0.690369832574101,0.153044674980176,FALSE +"transcriptomics","Log2FC","KEGG_FOCAL_ADHESION",0.30588,0.886,0.635,6359,0.975,"PAK6, CHAD, ERBB2, LAMA3, VAV1, ITGB6, PDGFA, PIK3R2, LAMB3, ITGB8, RAC2, VAV3, VEGFB, TNC, LAMC2, ITGB4, MAPK3, PPP1CA, VAV2, PDGFB, PIK3CA, PPP1CB, MET, IGF1R, THBS3, VWF, PDGFD, ITGA3, EGFR, RAP1A, THBS1, ITGA2B, BRAF, CAV2, PXN, COL1A1, SRC, CAV1, MYL9, ARHGAP35, PAK2, LAMA5, BAD, PGF, LAMB1, ITGA2, COL5A1, VEGFA, RASGRF1, PIK3R3, PIP5K1C, CRKL, MYL7, ARHGAP5, VEGFC, RAC1, PAK1, BCAR1, PAK4, MAPK1, MAPK10, PIK3R5, PIK3CB, PTEN, COL1A2, ITGA5, TLN2, GSK3B, COL6A1, DIAPH1, ITGA4, CAPN2",0.197226274708024,0.0109953843014632,FALSE +"transcriptomics","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.42522,1.24,0.17,5764,0.758,"ALPP, QDPR, SPR, FPGS",0.769551078621726,0.120330794367946,FALSE +"transcriptomics","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.5816,1.66,0.0143,3752,0.308,"ALDOC, PFKFB2, HK2, MPI, GMPPA, FBP1, GMPPB, PFKL, FBP2, MTMR1, FPGT, HK1, PFKFB4, ALDOA",1.84466396253494,0.511449283499556,FALSE +"transcriptomics","Log2FC","KEGG_GALACTOSE_METABOLISM",0.52612,1.52,0.0332,3636,0.508,"HK2, GCK, GAA, PGM1, PFKL, B4GALT1, GALT, GANC, HK1, B4GALT2, GLB1, GALE",1.47886191629596,0.294136287716081,FALSE +"transcriptomics","Log2FC","KEGG_GAP_JUNCTION",-0.17017,-0.584,0.981,15556,0.991,"ADRB1, TUBB3, ITPR2, MAP2K5, ADCY7, PRKX, TUBA1B, TUBB, GNAI1, ITPR1, TUBAL3, PRKACB, CDK1, PLCB4, PDGFRA, TUBA1A, NRAS, TUBB4A, TUBB2B, TUBB2A",0.0083309926200515,0.00392634551472468,FALSE +"transcriptomics","Log2FC","KEGG_GLIOMA",0.26293,0.768,0.824,3686,1,"PDGFA, PIK3R2, PLCG2, CALML3, CAMK2G, MAPK3, PDGFB, PIK3CA, IGF1R, EGFR, E2F1, BRAF, PLCG1, TGFA",0.0840727883028842,0,FALSE +"transcriptomics","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.33643,0.966,0.511,4600,0.867,"GSTK1, GGT7, GSTT2, GSTO2, GSS, IDH2, GSTZ1, GSTA3, OPLAH, MGST2, GGT6, GPX1, MGST3, ANPEP, G6PD, GPX3",0.291579099865287,0.0619809025237897,FALSE +"transcriptomics","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.17981,0.523,0.997,5968,0.996,"DGKA, LIPG, DGAT1, MGLL, TKFC, PLPP3, CEL, DGKH, AGPAT2, PNPLA3, DGKI, AWAT2, MBOAT1, DGKE",0.00130484168834428,0.00174066157630127,FALSE +"transcriptomics","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.36747,1.06,0.355,5053,0.757,"PISD, CDS1, PLA2G12A, CHKB, DGKA, PLD1, PLA2G6, PLA2G4B, PLD2, PCYT2, CHKA, LPCAT2, ETNK2, CDS2, PLA2G10, PLA2G4E, PLPP3, MBOAT7, LPCAT4, PLA2G2C, DGKH, AGPAT2, PGS1, LPCAT3, LYPLA2, ACHE, PCYT1A, DGKI",0.449771646944906,0.120904120499927,FALSE +"transcriptomics","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.31093,0.908,0.606,6983,0.965,"AGXT, GCAT, AOC2, GATM, SARDH, SHMT1, MAOA, AMT, GAMT, CTH, SDS, GNMT, AOC3, ALAS2, SRR",0.217527375833714,0.0154726866562074,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.4334,1.24,0.153,1880,0.758,"LDHC, ADH7, ACSS2, ALDH3B2, ALDOC, HK2, ALDH1A3, GCK, ALDH3B1, FBP1, PGM1, GALM, PFKL",0.815308569182401,0.120330794367946,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.43624,1.27,0.141,4160,0.753,"B4GALT7, CHPF, CHST12, XYLT2, CHST14, XYLT1, CHPF2, CHST11, CHST15",0.85078088734462,0.123205023799299,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.45434,1.32,0.103,3529,0.849,"B4GALT7, EXT1, HS3ST1, XYLT2, HS6ST1, NDST1, HS6ST2, XYLT1",0.987162775294828,0.0710923097560473,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66703,1.93,0,3600,0.287,"B3GNT7, CHST6, B4GALT4, B4GALT1, B3GNT2, CHST4, ST3GAL1, B4GALT2",Inf,0.542118103266008,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.5591,1.62,0.0235,4196,0.347,"HGSNAT, NAGLU, HPSE, HYAL4, IDS, GALNS, HYAL2, GUSB, GLB1, HEXB",1.62893213772826,0.459670525209126,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.42593,1.23,0.161,6306,0.722,"ST6GALNAC5, B3GALT4, SLC33A1, ST3GAL1, GLB1, HEXB, ST6GALNAC6, ST6GALNAC4, HEXA, ST8SIA1",0.79317412396815,0.141462802430361,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.58271,1.69,0.00992,4276,0.351,"FUT2, FUT1, NAGA, B3GALNT1, ST3GAL1, GBGT1, A4GALT, HEXB, B3GALT5",2.00348832784582,0.454692883534176,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.59777,1.73,0.0122,3600,0.331,"B3GNT3, ABO, FUT3, FUT2, B4GALT4, B3GNT5, B3GNT4, B4GALT1, FUT1, B3GNT2, ST3GAL4, B4GALT2",1.91364016932525,0.480172006224281,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.50004,1.43,0.0601,3611,0.648,"PIGT, PIGU, GPAA1, PIGZ, PIGV, PIGQ, PIGL, PIGX, PIGS",1.22112552799726,0.188424994129407,FALSE +"transcriptomics","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.50461,-1.86,0,16224,0.142,"HYI, MTHFD2L, MTHFD2, ACO1, CS, MTHFD1L, HAO2",Inf,0.847711655616944,TRUE +"transcriptomics","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.34964,1.01,0.437,2596,0.816,"PRKCD, PLA2G12A, MAPK13, PLD1, CACNA1D, PLA2G6, CALML3, PLA2G4B, MAP3K4, PLD2, CAMK2G, MAPK3, MAP3K1, ADCY5, CGA, ADCY4, MMP14, PTK2B, PLA2G10, EGFR, PLA2G4E",0.359518563029578,0.0883098412461389,FALSE +"transcriptomics","Log2FC","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.20626,-0.727,0.913,3907,1,"IL6, IL1A, KLRC1, KIR2DL1, IL1B, KIR2DL3, KIR3DL2, CD86, FAS, CD80, IFNG, CD28, TNF, KLRD1, GZMB, FASLG, IL2, PRF1",0.039529222465701,0,FALSE +"transcriptomics","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.36379,1.05,0.365,2621,0.765,"WNT3A, WNT9A, WNT7B, BMP7, WNT7A, WNT4, BMP2, CSNK1E, WNT10A, CSNK1A1, GLI3",0.437707135543525,0.116338564846382,FALSE +"transcriptomics","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.38485,1.11,0.278,6109,0.717,"CSF1R, IL9R, IL4R, TFRC, EPOR, FLT3LG, CD44, ITGA3, CD9, ITGA2B, CD19, IL7R, EPO, IL6R, IL6, ANPEP, CD59, ITGA2, CSF2, CD4, IL1R2, CSF1, IL1A, IL1R1, CD1D, CD55, ITGA5",0.555955204081924,0.1444808443322,FALSE +"transcriptomics","Log2FC","KEGG_HISTIDINE_METABOLISM",0.35152,1.02,0.413,1584,0.795,"ALDH3B2, HEMK1, HAL, ALDH1A3, ALDH3B1",0.384049948343599,0.0996328713435297,FALSE +"transcriptomics","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",0.23381,0.681,0.93,764,0.991,"POLD4, SEM1",0.0315170514460649,0.00392634551472468,FALSE +"transcriptomics","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.17121,-0.598,1,16664,1,"ITPR1, NDUFS4, BBC3, AP2S1, SOD1, COX6B1, COX7A2, DCTN4, AP2A2, PLCB4, ATP5F1C, NDUFA9, VDAC2, POLR2E, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, HDAC2, HIP1, TBPL1, TBP, UCP1, ATP5F1A, POLR2D, BDNF, NDUFS5, TFAM, GRIN2B",0,0,FALSE +"transcriptomics","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.30969,0.892,0.644,4437,0.978,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ITGA3, CACNB2, DAG1, ITGA2B, PRKAA1, ACE, TNNT2, IL6, TNNC1, ITGA2, PRKAG2",0.191114132640188,0.00966114521239857,FALSE +"transcriptomics","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.30094,0.87,0.675,6116,0.977,"PLCG2, INPP4B, PLCD1, INPP4A, ALDH6A1, PIK3CA, PIP4K2C, PLCG1, PIK3C2G, PIK3C2B, INPP5K, IMPA2, PIP5K1C, INPPL1, INPP5J, ISYNA1, PIK3CB, PTEN, PLCB3, IPMK",0.170696227168975,0.0101054362812269,FALSE +"transcriptomics","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.32542,0.943,0.545,6911,0.915,"CBLC, PPP1R3D, HK2, PTPN1, PIK3R2, GYS1, CALML3, SOCS1, MKNK1, GCK, IKBKB, MAPK3, RPS6KB2, FBP1, INSR, PPP1CA, SH2B2, PIK3CA, PPP1CB, PRKCI, TSC1, FBP2, IRS2, PTPRF, CBLB, BRAF, PRKAA1, PHKG1, HK1, FOXO1, PRKCZ, BAD, PRKAG2, INPP5K, EXOC7, PIK3R3, FASN, PYGL, CALML6, CRKL, PRKAB2, PRKACA, RHEB, PPP1R3B, MAPK1, FLOT2, MAPK10, PIK3R5, IRS1, PIK3CB, PRKAR1B, GSK3B, PHKG2, TRIP10, GRB2, INPP5D, PYGB, PRKAG1, TSC2, RPTOR",0.263603497723358,0.0385789059335517,FALSE +"transcriptomics","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.3125,0.903,0.612,3908,0.958,"TNFSF13, ICOSLG, LTBR, CCL28, CD40, PIGR, IL6",0.213248577854439,0.0186344909214556,FALSE +"transcriptomics","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.33678,0.975,0.51,5894,0.87,"IFNL3, IFNL1, CBLC, STAT2, IFNL2, CRLF2, PIK3R2, IL9R, IRF9, JAK3, IL4R, SOCS1, CISH, IFNLR1, EPOR, PTPN6, IFNB1, PIK3CA, TYK2, EP300, STAT6, CTF1, STAT5B, IL12B, CBLB, STAT3, CLCF1, IL7R, EPO, IL20RB, IL6R, IL6, PIAS3, IL20RA, PIM1, CSF2, PIK3R3, SPRY1, IL15RA, STAT1, IL12A, PRLR, GH2, STAT5A, OSMR, IFNGR1, JAK1, CSF2RB, STAM2, PIK3R5, PIK3CB",0.292429823902064,0.0604807473813815,FALSE +"transcriptomics","Log2FC","KEGG_LEISHMANIA_INFECTION",0.42556,1.23,0.172,6358,0.722,"TRAF6, ITGB2, NCF4, MAPK13, MAPK3, PTPN6, MYD88, IL12B, TAB1, RELA, MAPK11, C3, TLR2, IRAK4, STAT1, IL12A, TGFB3, IL1A, IFNGR1, JAK1, TAB2, MAPK1, NFKBIA, FOS, ITGA4",0.764471553092451,0.141462802430361,FALSE +"transcriptomics","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.41873,1.22,0.171,3793,0.694,"CTNND1, CLDN8, ITGB2, MMP9, CLDN9, VAV1, NCF4, CLDN7, MAPK13, PIK3R2, PLCG2, CLDN4, F11R, CDH5, RAC2, VAV3, VAV2, CLDN18, PIK3CA, RASSF5, PTK2B, RAP1A, CLDN11, RAPGEF3, PLCG1, SIPA1, PXN, CLDN23, CLDN3, MYL9, MAPK11, ARHGAP35",0.767003889607846,0.158640529545145,FALSE +"transcriptomics","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.42081,-1.51,0.07,15341,0.292,"ALDH3A2, HADHA, YOD1, ALDH1B1, ALDH7A1, ALDH9A1",1.15490195998574,0.534617148551582,FALSE +"transcriptomics","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",0.40266,1.16,0.214,2596,0.723,"PLA2G12A, CYP2E1, PLA2G6, PLA2G4B, CYP2J2, PLA2G10, PLA2G4E",0.669586226650809,0.140861702705469,FALSE +"transcriptomics","Log2FC","KEGG_LONG_TERM_DEPRESSION",0.24312,0.691,0.925,6599,0.996,"PLA2G12A, GNAO1, PLA2G6, PLA2G4B, MAPK3, IGF1R, RYR1, PLA2G10, PLA2G4E, BRAF, PLA2G2C, GNAS, GNAQ, LYN, ITPR3, MAPK1, PLCB3, PPP2R1A, GUCY1A1, NOS1, PLA2G2F, GUCY1B1, GNA12",0.0338582672609674,0.00174066157630127,FALSE +"transcriptomics","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.23447,0.675,0.931,5774,0.989,"GRIN1, CALML3, CAMK2G, MAPK3, PPP1CA, PPP1CB, EP300, RAP1A, RAPGEF3, GRIN2A, BRAF, GRIN2D, CHP1, PPP3CA, GNAQ, RPS6KA2, CALML6, ITPR3, PRKACA, MAPK1, RPS6KA1",0.0310503190186574,0.0048037084028206,FALSE +"transcriptomics","Log2FC","KEGG_LYSINE_DEGRADATION",0.22598,0.649,0.95,2472,0.994,"BBOX1, KMT5B, KMT5C, GCDH, AASDH, EHHADH",0.0222763947111523,0.00261361560268669,FALSE +"transcriptomics","Log2FC","KEGG_LYSOSOME",0.52683,1.51,0.0375,5277,0.488,"CTSH, GM2A, CTSA, CTSV, HGSNAT, SLC11A1, NAGLU, GGA2, CTSD, ARSA, ATP6V0D2, LIPA, DNASE2, ABCB9, SUMF1, GAA, MANBA, NPC1, NAGA, ACP5, PSAP, IDS, GNPTG, NPC2, AP1M2, GALNS, CTSS, LAPTM4A, NAPSA, AP1B1, AP3M2, GGA1, LGMN, NEU1, TPP1, ATP6AP1, PSAPL1, ASAH1, LAMP3, CD68, CTSB, LAMP1, CLN5, GUSB, GLB1, GGA3, AP3S2, LAMP2, FUCA1, NAGPA, SCARB2, CTSE, HEXB, PPT1, AP1S1, TCIRG1, MAN2B1, CD63, SLC11A2, MFSD8, ABCA2, CTSZ, SORT1, AP1S3, ATP6V0A4, ENTPD4, GBA",1.42596873227228,0.311580177997289,FALSE +"transcriptomics","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",0.26798,0.775,0.836,5856,1,"NTF4, PLA2G12A, TRAF6, FGF11, FGFR2, MAPK13, PDGFA, CACNA1D, RAC2, CACNG1, PLA2G6, PLA2G4B, MAP3K4, MKNK1, DUSP9, CACNB3, HSPB1, CACNG4, IKBKB, MAPK3, ARRB1, MAP4K1, MAP3K1, PDGFB, CACNA1I, FGF1, DUSP3, MAPK8IP2, MAX, NTRK2, PLA2G10, EGFR, CACNB2, PLA2G4E, MAP3K11, MAPKAPK3, RAP1A, JUND, ECSIT, MAP3K6, TAB1, LAMTOR3, FGFR3, MAP3K13, TAOK3, BRAF, DUSP10, RELA, STK3, DUSP14, CHP1, HSPA1B, MAPK11, PPP3CA, PAK2, PLA2G2C, MECOM, MAP3K8, GADD45B, RASGRF1, FGF12, MAP4K2, MAP3K5, RPS6KA2, IL1R2, RASA1, RPS6KA4, MAPKAPK2, NF1, STK4, TGFB3, CRKL, PPM1A, HSPA2, NGF, PRKACA, IL1A, RAC1, PAK1, MAP4K3, TGFBR2, RRAS, TAB2, MAPK1, DUSP8, MAP2K7, NLK, GADD45A, RPS6KA1, MAPK10, MAPK8IP3, CACNA1F",0.0777937225609836,0,FALSE +"transcriptomics","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26478,0.764,0.846,1432,0.999,"HES1, GCK",0.0726296369609765,0.000434511774017692,FALSE +"transcriptomics","Log2FC","KEGG_MELANOGENESIS",0.36219,1.06,0.354,6175,0.757,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, GNAO1, CALML3, WNT4, DVL3, CAMK2G, MAPK3, ADCY5, WNT10A, ADCY4, EP300, ADCY6, TCF7L1, FZD4, CREB3L4, DVL2, WNT11, GNAS, GNAQ, CALML6, CREB3L3, MITF, PRKACA, ASIP, CREB3L2, MAPK1, EDN1, CREB3L1, WNT5A, PLCB3, FZD6, GSK3B",0.450996737974212,0.120904120499927,FALSE +"transcriptomics","Log2FC","KEGG_MELANOMA",-0.26432,-0.951,0.453,16564,0.793,"PIK3R1, PIK3CG, FGF20, CDK6, FGF21, FGF2, PDGFRA, E2F2, NRAS, IGF1, FGF9, FGF4, CDKN2A, FGF5, FGFR1, E2F3, FGF19, FGF3",0.343901797987168,0.100726812682396,FALSE +"transcriptomics","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.45636,1.31,0.105,3662,0.846,"ADH7, ALDH3B2, GSTK1, DHDH, CYP2E1, CYP1B1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, MGST2, UGT2B17, MGST3",0.978810700930062,0.0726296369609765,FALSE +"transcriptomics","Log2FC","KEGG_MISMATCH_REPAIR",-0.32549,-1.13,0.294,15319,0.63,"MSH6, RFC3, MSH3, RFC2, RFC5, EXO1, MSH2, RFC1, RPA2",0.531652669587843,0.200659450546418,FALSE +"transcriptomics","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.35512,1.02,0.389,6050,0.795,"PIK3R2, VEGFB, MAPK3, RPS6KB2, PIK3CA, TSC1, CAB39, RICTOR, BRAF, PRKAA1, PGF, VEGFA, PIK3R3, HIF1A, RPS6KA2, DDIT4, VEGFC, RHEB, MAPK1, RPS6KA1, PIK3R5, PIK3CB, ULK1",0.410050398674292,0.0996328713435297,FALSE +"transcriptomics","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.2602,0.751,0.859,6624,0.986,"ITGB2, VAV1, PIK3R2, PLCG2, RAC2, VAV3, RAET1L, MAPK3, PTPN6, VAV2, IFNB1, PIK3CA, SH3BP2, PTK2B, TNFSF10, BRAF, PLCG1, CHP1, PPP3CA, LCK, CSF2, PIK3R3, ULBP2, RAC1, IFNGR1, PAK1, BID, MAPK1, NFATC1, PIK3R5, PIK3CB, SYK, NFATC4, HCST, GRB2, CHP2",0.0660068361687577,0.0061230850587888,FALSE +"transcriptomics","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.21335,0.617,0.956,5100,0.991,"DRD5, P2RY2, VIPR2, PTAFR, BDKRB2, P2RY6, P2RX4, LPAR2, VIPR1, S1PR4, THRB, GRIN1, NPBWR1, ADORA1, ADORA2B, ADORA2A, GIPR, S1PR2, GALR3, CGA, BDKRB1, GHSR, GABRP, F2RL3, GRIN2A, OPRL1, CHRNB4, MLNR, S1PR5, ADRB2, GRIN2D, P2RX6, EDNRA, F2RL1, MC3R, P2RX2, LTB4R2, HTR7, CHRNB1, ADRA2A, GRIN3B, GRM4, LTB4R, PRLR, ADRA2B, GH2",0.0195421077238999,0.00392634551472468,FALSE +"transcriptomics","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.33316,0.965,0.496,5975,0.86,"GAB1, NTF4, PRKCD, TRAF6, MAPK13, PIK3R2, PLCG2, FOXO3, CALML3, ARHGDIB, IKBKB, CAMK2G, MAPK3, MAP3K1, SH2B2, PIK3CA, NTRK2, RAP1A, IRS2, TP73, BRAF, PLCG1, YWHAB, RELA, MAPK11, NGFR, IRAK4, BAD, YWHAZ, MAP3K5, PIK3R3, YWHAH, RPS6KA2, SORT1, CALML6, RPS6KA4, MAPKAPK2, CRKL, NGF, RAC1, BAX, MAPK1, MAP2K7, RPS6KA1, MAPK10, PIK3R5, IRS1, PIK3CB, NFKBIA",0.304518323509803,0.0655015487564323,FALSE +"transcriptomics","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.264,0.761,0.824,4274,0.987,"QPRT, NMRK1, NADSYN1, NADK, NT5C1B",0.0840727883028842,0.00568284733036327,FALSE +"transcriptomics","Log2FC","KEGG_NITROGEN_METABOLISM",0.31831,0.912,0.593,2116,0.964,"GLUL, HAL, GLS2, CA9",0.226945306635737,0.0159229660971692,FALSE +"transcriptomics","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.34339,0.989,0.455,4477,0.848,"CASP1, TRAF6, MAPK13, TAB3, IKBKB, MAPK3, TRIP6, CCL5, IL18, PYCARD, TAB1, RELA, CARD6, MAPK11, IL6, NOD1, NOD2, PSTPIP1, NLRP1",0.341988603342888,0.0716041477432862,FALSE +"transcriptomics","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.55072,-1.98,0.00877,17605,0.159,"RAD50, PRKDC, NHEJ1, XRCC5",2.05700040663396,0.798602875679548,TRUE +"transcriptomics","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.34338,0.99,0.464,3686,0.856,"ERBB2, RXRA, PIK3R2, PLCG2, FOXO3, MAPK3, PIK3CA, RASSF5, RXRB, EGFR, E2F1, BRAF, PLCG1, TGFA",0.333482019445119,0.0675262353228468,FALSE +"transcriptomics","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.39588,1.15,0.228,5482,0.71,"DTX4, HES1, DVL3, DTX3L, JAG1, DTX2, RFNG, EP300, DLL1, LFNG, NOTCH3, APH1A, MFNG, DVL2, JAG2, NUMB, NOTCH1, KAT2A, HES5",0.642065152999546,0.148741651280925,FALSE +"transcriptomics","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.30853,-1.12,0.24,15978,0.616,"RFC2, XPC, RFC5, GTF2H1, XPA, GTF2H3, ERCC3, CUL4A, ERCC8, CCNH, ERCC1, POLE3, RFC1, RPA2, GTF2H2",0.619788758288394,0.210419287835575,FALSE +"transcriptomics","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.39086,1.14,0.257,3600,0.714,"MAN1B1, RPN2, ALG12, ALG3, DPM1, MOGS, MGAT4A, MGAT1, B4GALT1, MGAT5B, STT3A, ALG2, B4GALT2",0.590066876668705,0.146301788223826,FALSE +"transcriptomics","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",0.24959,0.725,0.88,7709,1,"OR4C6, OR10H2, OR2J3, OR11H4, OR8A1, OR2A12, OR2D3, GUCY2D, CALML3, OR8B8, CAMK2G, CLCA2, OR1G1, OR2A7, OR13H1, OR1I1, OR13D1, CNGB1, OR1F1, OR8G5, OR8G1, OR10A3, OR1M1, OR6Q1, OR1K1, OR5P2, OR10H1, OR10A4, OR4D2, OR2A2, CNGA4, OR52B4, CALML6, OR2D2, OR2B2, OR1J1, OR6B1, PRKACA, OR2A14, GUCA1B, OR52K1, OR9A2, OR10A6, OR4L1, OR10AD1, OR2S2, OR10S1, OR10A2, OR2A5, OR10K2, OR10A5, OR8S1, OR4X2, OR5P3, ADCY3, OR6C70, OR8D2, OR8B4, OR2L2, CAMK2D, OR10G3, PRKG2, OR4K1, PRKACG, GRK3, OR8D1, OR52I1, OR6A2",0.0555173278498314,0,FALSE +"transcriptomics","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.44426,-1.55,0.0515,14974,0.29,"DHFR, SHMT2, MTHFS, MTR, MTHFD2L, GART, MTHFD2, MTHFD1L, TYMS, ATIC",1.28819277095881,0.537602002101044,FALSE +"transcriptomics","Log2FC","KEGG_OOCYTE_MEIOSIS",-0.25168,-0.852,0.579,15742,0.967,"ITPR2, PPP2R5D, PPP3CC, ADCY7, PPP2R5C, PRKX, RPS6KA3, PTTG2, PPP2CB, PPP2R1B, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, ITPR1, ANAPC10, FBXO5, CDC20, PRKACB, PPP3R1, CDK1, SMC1A, CALM2, CCNB1, FBXO43, CPEB1, AR, PTTG1, YWHAQ, SGO1, SMC3, IGF1, PPP1CC, ANAPC13",0.237321436272564,0.0145735259169983,FALSE +"transcriptomics","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",0.61199,1.79,0.00444,5940,0.424,"MANBA, NEU1, ENGASE, MAN2B2, MAN2C1, GLB1, FUCA1, HEXB, MAN2B1, GBA, HEXA, AGA",2.35261702988538,0.372634143407267,FALSE +"transcriptomics","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",0.23049,0.669,0.947,6376,0.986,"NDUFV1, LHPP, ATP6V1C2, COX5B, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP5F1E, NDUFB7, NDUFS8, NDUFA3, NDUFV2, ATP6AP1, COX6C, UQCR10, COX6B2, SDHD, UQCR11, TCIRG1, NDUFB4, NDUFAB1, ATP6V1G1, UQCRB, ATP6V0A4, NDUFA6, UQCRHL, NDUFA5, UQCRC1, NDUFB5, COX15, ATP5MG, UQCRFS1, ATP6V1C1, UQCRC2, COX6A1, ATP6V1E1, NDUFA2, COX17, ATP5PD",0.0236500209967266,0.0061230850587888,FALSE +"transcriptomics","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.49419,1.42,0.0706,4056,0.638,"GALNT12, GALNT3, GALNT7, GALNT6, B4GALT5, GCNT1, ST6GALNAC1, GCNT3, C1GALT1, GALNT15, ST3GAL1, GALNT11, GALNT9, B3GNT6",1.1511952989482,0.195179321278838,FALSE +"transcriptomics","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.1914,0.552,0.994,5981,0.999,"TP53AIP1, CCNG2, CD82, SERPINB5, SFN, THBS1, TP73, ATR, PERP, SHISA5, EI24, GADD45B, ZMAT3, CCNE1, SIAH1, PIDD1, BID, IGFBP3, BAX, CHEK2, GADD45A, PTEN",0.00261361560268669,0.000434511774017692,FALSE +"transcriptomics","Log2FC","KEGG_PANCREATIC_CANCER",0.34675,0.998,0.462,5894,0.842,"ERBB2, PLD1, PIK3R2, RALB, RAC2, VEGFB, IKBKB, MAPK3, RALGDS, PIK3CA, EGFR, E2F1, RALBP1, STAT3, BRAF, RELA, TGFA, BAD, PGF, VEGFA, PIK3R3, STAT1, TGFB3, RALA, VEGFC, RAC1, JAK1, TGFBR2, MAPK1, MAPK10, PIK3R5, PIK3CB",0.335358024443874,0.0746879085003505,FALSE +"transcriptomics","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.31788,0.916,0.602,8542,0.964,"PANK2, PPCS, ENPP1, COASY, UPB1, PPCDC, BCAT2, DPYD, VNN2",0.220403508742175,0.0159229660971692,FALSE +"transcriptomics","Log2FC","KEGG_PARKINSONS_DISEASE",-0.18037,-0.606,0.98,17631,1,"UBE2J2, ATP5F1C, NDUFA9, VDAC2, LRRK2, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, UCHL1, ATP5F1A, SLC18A2, PARK7, NDUFS5",0.00877392430750515,0,FALSE +"transcriptomics","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.30571,-1.11,0.294,18248,0.572,"YWHAQ, TUBA1A, NCL, ROCK2, TUBB4A, ARHGEF2, TUBB2B, TUBB2A",0.531652669587843,0.242603971206976,FALSE +"transcriptomics","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.2849,0.828,0.733,5981,1,"WNT3A, WNT9A, CBLC, CSF1R, WNT7B, CDH1, ERBB2, FZD10, LAMA3, TRAF6, FGF11, MMP9, RXRA, BCR, FGFR2, TRAF4, PLD1, PDGFA, PIK3R2, PLCG2, RALB, LAMB3, EGLN3, WNT7A, RAC2, WNT4, VEGFB, LAMC2, DVL3, IKBKB, MAPK3, RALGDS, PML, PDGFB, RARA, BMP2, FLT3LG, PIK3CA, JUP, RASSF5, WNT10A, FADD, RXRB, MET, IGF1R, FGF1, MAX, ITGA3, EP300, EGFR, GLI3, STAT5B, E2F1, DAPK1, RALBP1, FGFR3, ITGA2B, PPARG, CBLB, ARNT2, STAT3, BRAF, PLCG1, CDKN1B, RELA, TCF7L1, FZD4, TGFA, FOXO1, IL6, DVL2, MECOM, LAMA5, WNT11, RUNX1, BAD, PGF, PIAS3, LAMB1, EPAS1, ITGA2, VEGFA, FGF12, DAPK2, PIK3R3, HIF1A, STAT1, CCNA1, CCNE1, STK4, TGFB3, CRKL, PTCH1, RALA, MITF, SLC2A1, STAT5A, VEGFC, RAC1, JAK1, BID, TGFBR2, BAX, MAPK1, WNT5A, MAPK10, PIK3R5, TFG, PIK3CB, CEBPA, NFKBIA, PTEN",0.134896025358872,0,FALSE +"transcriptomics","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.47895,1.39,0.0802,4741,0.659,"DHDH, UGT2B17, GUSB, RPEL1, DCXR",1.09582563171584,0.18111458540599,FALSE +"transcriptomics","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.43515,1.27,0.12,5085,0.753,"PGLS, ALDOC, FBP1, PGM1, PFKL, FBP2, ALDOA, H6PD, G6PD, RPEL1, RBKS, DERA, PGM2",0.920818753952375,0.123205023799299,FALSE +"transcriptomics","Log2FC","KEGG_PEROXISOME",0.42548,1.23,0.158,5270,0.722,"CAT, ACOT8, GSTK1, PRDX5, PEX11A, XDH, PXMP4, ACAA1, MVK, AGXT, PEX11G, PEX2, HMGCL, EPHX2, PAOX, IDH2, ACSL1, EHHADH, PEX11B, CROT, ABCD1, ACOX1, ACSL3, PEX10, PEX13, PEX26, SCP2, PEX7, MLYCD, SLC25A17, ABCD4, PEX1, ACSL5, ACSL6",0.801342913045577,0.141462802430361,FALSE +"transcriptomics","Log2FC","KEGG_PHENYLALANINE_METABOLISM",0.40531,1.18,0.19,5148,0.703,"ALDH3B2, ALDH1A3, ALDH3B1, AOC2, NAA80, IL4I1, TAT, MAOA, MIF",0.721246399047171,0.153044674980176,FALSE +"transcriptomics","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.30436,0.867,0.668,6064,0.975,"CDS1, DGKA, PIK3R2, PLCG2, INPP4B, PLCD1, CALML3, INPP4A, PIK3CA, PIP4K2C, CDS2, PLCG1, PIK3C2G, PIK3C2B, DGKH, INPP5K, IMPA2, PIK3R3, PIP5K1C, CALML6, DGKI, ITPR3, INPPL1, INPP5J, PIK3R5, PIK3CB, DGKE, PTEN, PLCB3",0.175223537524454,0.0109953843014632,FALSE +"transcriptomics","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.31034,0.905,0.588,4098,0.963,"ALAD, CP, HMOX2, FTH1, UGT2B17, MMAB, GUSB, HMBS",0.230622673923862,0.0163737128754655,FALSE +"transcriptomics","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.41424,1.2,0.182,5270,0.705,"RXRA, ACAA1, CPT1B, PPARA, PLIN1, CYP4A22, FABP6, ACSL1, RXRB, CPT2, CPT1C, EHHADH, SLC27A6, PLTP, SLC27A1, PPARG, ACOX1, ACSL3, SCD5, SLC27A4, SCP2, OLR1, ACSL5, ACSL6",0.739928612014925,0.151810883008601,FALSE +"transcriptomics","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.20209,-0.707,0.827,14148,1,"ACOX2, HSD17B4, CYP7A1, HSD3B7, AKR1C4, CYP39A1, BAAT",0.0824944904474534,0,FALSE +"transcriptomics","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",0.5701,1.67,0.00988,4719,0.337,"RFXANK, BLNK, RAG1, JAK3, CD40, ADA, CD79A, RAG2, CD19, IL7R, CIITA, LCK, CD4",2.00524305541237,0.472370099128661,FALSE +"transcriptomics","Log2FC","KEGG_PRION_DISEASES",0.24524,0.707,0.912,5622,0.994,"MAPK3, CCL5, IL6, NOTCH1, PRKACA, IL1A, C9, BAX, MAPK1, EGR1",0.0400051616715838,0.00261361560268669,FALSE +"transcriptomics","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28022,-1.01,0.396,15860,0.704,"ADCY7, PRKX, RPS6KA3, CCNA2, AKT3, MAD2L2, BUB1, CDC25C, CDC23, PIK3R1, GNAI1, PIK3CG, CCNB2, ANAPC10, PRKACB, CDK1, CCNB3, CDC25A, CCNB1, MAPK8, CPEB1, IGF1, HSP90AB1, HSP90AA1, ANAPC13, PDE3A, PDE3B",0.402304814074488,0.152427340857888,FALSE +"transcriptomics","Log2FC","KEGG_PROPANOATE_METABOLISM",0.35657,1.04,0.385,3581,0.764,"LDHC, ACSS2, ALDH6A1, ABAT, MCEE, EHHADH, PCCB, ACSS1",0.414539270491499,0.11690664142431,FALSE +"transcriptomics","Log2FC","KEGG_PROSTATE_CANCER",0.26783,0.777,0.821,6422,1,"ERBB2, FGFR2, PDGFA, PIK3R2, IKBKB, MAPK3, PDGFB, PIK3CA, IGF1R, PDGFD, EP300, EGFR, E2F1, BRAF, CDKN1B, RELA, TCF7L1, CREB3L4, TGFA, FOXO1, BAD, PIK3R3, CCNE1, CREB3L3, CREB3L2, MAPK1, CREB5, CREB3L1, PIK3R5, PIK3CB, NFKBIA, PTEN, GSK3B, CDKN1A, CREB3",0.0856568428805592,0,FALSE +"transcriptomics","Log2FC","KEGG_PROTEASOME",-0.31612,-1.05,0.337,15132,0.64,"PSMB5, PSMD4, PSMD6, PSMC5, PSMB4, PSMA6, PSMD7, PSMC1, PSMC6, PSMD1, PSMC4, PSMB7, PSMA4, PSMA1, PSMD8, PSMB1, POMP, PSMD14",0.472370099128661,0.193820026016113,FALSE +"transcriptomics","Log2FC","KEGG_PROTEIN_EXPORT",-0.31244,-1.11,0.273,16054,0.572,"SEC61A2, SEC11A, SRPRB, SRP72, SRP9, SRP19, SEC11C, SEC63",0.563837352959244,0.242603971206976,FALSE +"transcriptomics","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.19349,0.562,0.991,8289,1,"GLS2, SLC9A3, SLC25A10, MDH1, SLC4A4, GLUD1, ATP1A2, AQP1, ATP1A1",0.00392634551472468,0,FALSE +"transcriptomics","Log2FC","KEGG_PURINE_METABOLISM",-0.30249,-1.08,0.287,15717,0.603,"PNPT1, PRPS1, RRM2, ADCY7, PFAS, POLR3B, ENTPD8, POLR2L, RRM2B, PAICS, ADSL, APRT, GART, NPR2, RRM1, PDE6B, PNP, PRIM1, NME1, PDE6C, POLR3G, PDE8A, POLR3A, AK5, NME7, PPAT, PDE11A, PRIM2, POLE3, POLR2E, POLR3C, PDE1A, ATIC, ENTPD1, PDE4B, PDE4D, POLR2D, POLR1E, PDE3A, PDE3B, POLA1, PDE10A, PDE7B, PDE8B",0.542118103266008,0.219682687859849,FALSE +"transcriptomics","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.25943,-0.935,0.464,14988,0.804,"DHODH, POLE, NT5E, NME2, UPP2, CAD, POLR2C, POLR3K, PNPT1, RRM2, POLR3B, ENTPD8, POLR2L, RRM2B, AK3, TXNRD1, DTYMK, RRM1, PNP, PRIM1, NME1, TYMS, POLR3G, POLR3A, NME7, PRIM2, POLE3, POLR2E, POLR3C, ENTPD1, POLR2D, POLR1E, UCK2, POLA1, CTPS1",0.333482019445119,0.0947439512515487,FALSE +"transcriptomics","Log2FC","KEGG_PYRUVATE_METABOLISM",0.22031,0.635,0.947,1378,0.989,"LDHC, ACSS2, PC",0.0236500209967266,0.0048037084028206,FALSE +"transcriptomics","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.28027,0.814,0.746,5612,1,"PAK6, SSH3, BDKRB2, MYH14, BAIAP2, FGF11, ITGB2, VAV1, FGFR2, ITGB6, PDGFA, PIK3R2, ITGB8, RAC2, VAV3, LIMK2, FGD3, ITGB4, ARHGEF4, MAPK3, PPP1CA, VAV2, GSN, PDGFB, PFN4, PIK3CA, PPP1CB, PIP4K2C, BDKRB1, FGF1, SSH2, PDGFD, ITGA3, EGFR, FGFR3, ITGA2B, BRAF, TIAM1, PXN, MYL9, TIAM2, ARHGAP35, PAK2, SLC9A1, ITGA2, WASL, FGF12, PIK3R3, PIP5K1C, LIMK1, CRKL, ARHGEF7, SCIN, MYL7, RAC1, IQGAP1, PAK1, RRAS, BCAR1, ITGAX, PAK4, MAPK1",0.127261172527331,0,FALSE +"transcriptomics","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.20206,-0.654,0.892,18035,1,"PIK3C3, PRKAA2, IFNA13",0.0496351456238769,0,FALSE +"transcriptomics","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.3643,1.06,0.349,5894,0.757,"GAB1, PAK6, PIK3R2, EGLN3, VEGFB, MAPK3, PDGFB, PIK3CA, MET, EP300, RAP1A, ARNT2, BRAF, TGFA, PAK2, PGF, EPAS1, VEGFA, PIK3R3, HIF1A, TGFB3, CRKL, FLCN, SLC2A1, VEGFC, RAC1, PAK1, PAK4, MAPK1, PIK3R5, PIK3CB",0.45717457304082,0.120904120499927,FALSE +"transcriptomics","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.39819,1.16,0.224,4025,0.723,"CTSA, ACE2, ACE, ANPEP",0.649751981665837,0.140861702705469,FALSE +"transcriptomics","Log2FC","KEGG_RETINOL_METABOLISM",0.43832,1.25,0.138,5807,0.802,"ADH7, RDH16, CYP26B1, DHRS9, DHRS3, DGAT1, CYP4A22, CYP26A1, UGT2B17, CYP1A1, RDH10, RDH11, LRAT, CYP26C1, CYP2C9, CYP2A7, ALDH1A2, AWAT2, CYP2C8",0.860120913598763,0.0958256317158365,FALSE +"transcriptomics","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",0.28656,0.836,0.738,3165,1,"ACP6, ACP5, MTMR1",0.131943638176958,0,FALSE +"transcriptomics","Log2FC","KEGG_RIBOSOME",-0.37924,-1.32,0.141,14672,0.384,"RPL22L1, RPS23, RPL26, RPL21, RPL13A, RPS24, RPL10A, RPL37A, RPS11, RPS27A, RPL35, RPL10, RPL26L1, RPL34, RPL27A, RPLP0, RPL11, RPL32, RPS8, RPL18, RPS27, RPL9, RPS20, RPS10, RPS6, RPL4, RPL5, RPL14, RPSA, RPS13, RPS7, RPS19, RSL24D1, RPS12, RPL6, RPS4Y1, RPS16, RPL17",0.85078088734462,0.415668775632469,FALSE +"transcriptomics","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.42041,1.21,0.17,3761,0.689,"TRADD, TRAF6, DHX58, MAPK13, MAVS, IRF3, CXCL10, IKBKB, IFNB1, MAP3K1, TKFC, FADD, ISG15, IFIH1, DDX58, NLRX1, IL12B, CASP10, RELA, MAPK11, IKBKE",0.769551078621726,0.161780778092374,FALSE +"transcriptomics","Log2FC","KEGG_RNA_DEGRADATION",-0.39068,-1.29,0.137,15014,0.399,"CNOT7, LSM2, EXOSC6, LSM1, LSM5, CNOT1, PNPT1, DCP1A, LSM7, EDC4, LSM3, EXOSC9, CNOT10, EXOSC5, EXOSC3, PAPOLA, TTC37, ZCCHC7, EXOSC10, MTREX, ENO1, DCP2, CNOT9, ENO3, EXOSC8, HSPA9, DCP1B, HSPD1",0.863279432843593,0.399027104313252,FALSE +"transcriptomics","Log2FC","KEGG_RNA_POLYMERASE",-0.36582,-1.32,0.123,17492,0.384,"POLR3G, POLR3A, POLR2E, POLR3C, POLR2D, POLR1E",0.910094888560602,0.415668775632469,FALSE +"transcriptomics","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",-0.20795,-0.742,0.911,17399,1,"SCLY, MAT2A, MARS2, SEPHS1, TRMT11",0.0404816230270017,0,FALSE +"transcriptomics","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.2741,0.799,0.789,4622,1,"LAMA3, TRAF6, RXRA, TRAF4, PIK3R2, LAMB3, LAMC2, IKBKB, PIK3CA, RXRB, MAX, ITGA3, E2F1, ITGA2B, CDKN1B, RELA, LAMA5, PIAS3, LAMB1, ITGA2, PIK3R3",0.10292299679058,0,FALSE +"transcriptomics","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.44073,1.28,0.118,4358,0.809,"SNAP23, STX16, STX10, VAMP8, STX19, YKT6, STX17, VTI1B, TSNARE1, STX3, GOSR2, SNAP29, BET1, USE1, STX5, BET1L",0.928117992693875,0.0920514783877277,FALSE +"transcriptomics","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",0.24714,0.711,0.906,8272,1,"ARSA, SPTLC2, NEU1, ASAH1, PLPP3, DEGS2, SPHK2, GLB1, SPHK1, GBA, SGMS2, SGPP1, SPTLC1, ENPP7, UGCG, SMPD3, SMPD2, SGPP2, NEU2, SMPD1, UGT8",0.0428718023231869,0,FALSE +"transcriptomics","Log2FC","KEGG_SPLICEOSOME",-0.28279,-0.976,0.362,14820,0.761,"HSPA1A, SNRNP27, DDX23, LSM2, SF3A3, SF3B1, SNRPB, SNRPF, PRPF8, BCAS2, LSM5, PRPF3, THOC1, SRSF3, SF3A2, DDX39B, EIF4A3, LSM7, SF3B4, TCERG1, RBM22, U2AF1, LSM3, SNRNP40, SYF2, DDX5, HNRNPK, DHX15, HNRNPA1L2, BUD31, PQBP1, PRPF40A, THOC2, PRPF4, SNRPA1, RBM8A, ALYREF, CDC5L, RBM17, SRSF7, SNRPE, PRPF18, SNRPD2, CDC40, SNRPC, RBMX, SRSF1, HNRNPA3, HSPA8, HNRNPM, HNRNPA1, HNRNPC, SF3B5, MAGOHB, PPIH, HNRNPU, PPIE, TXNL4A, SRSF10",0.441291429466834,0.118615343229427,FALSE +"transcriptomics","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.44369,1.3,0.112,7075,0.803,"HK2, GYS1, GCK, GAA, PGM1, GANC, UGT2B17, GUSB, HK1, UXS1, PYGL, PGM2, ENPP1, MGAM, PYGB, AMY1A, UGP2, AGL",0.950781977329818,0.095284454721319,FALSE +"transcriptomics","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.61834,1.78,0.00564,5003,0.304,"MSMO1, DHCR24, LIPA, SC5D, SQLE, FDFT1, HSD17B7, CEL, NSDHL, DHCR7, LSS, TM7SF2",2.24872089601666,0.517126416391246,FALSE +"transcriptomics","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38862,1.13,0.264,4669,0.706,"CYP11B1, CYP1B1, SULT2B1, SRD5A1, COMT, SRD5A3, CYP7B1, UGT2B17, HSD17B7, SULT1E1, CYP1A1, HSD17B8",0.578396073130169,0.151195298948196,FALSE +"transcriptomics","Log2FC","KEGG_SULFUR_METABOLISM",0.55174,1.6,0.0215,5093,0.351,"SULT2B1, CHST12, SULT1A2, SUOX, SULT1A4, CHST11, SULT1E1, SULT1A3",1.66756154008439,0.454692883534176,FALSE +"transcriptomics","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.21402,-0.738,0.905,18576,1,"SSB, GRIN2B",0.0433514207947967,0,FALSE +"transcriptomics","Log2FC","KEGG_TASTE_TRANSDUCTION",0.22218,0.648,0.942,6205,0.987,"KCNB1, SCNN1A, ADCY4, TAS2R1, SCNN1G, TAS1R3, ADCY6, GNAS, TAS2R3, GRM4, TAS2R31, SCNN1B, ITPR3, PRKACA, TAS2R4, TAS2R38, TAS2R5",0.0259490972071227,0.00568284733036327,FALSE +"transcriptomics","Log2FC","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.24456,0.709,0.925,3450,1,"GGT7, GGT6",0.0338582672609674,0,FALSE +"transcriptomics","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.41775,1.22,0.183,5412,0.694,"MVK, HMGCS1, MVD, DHDDS, HMGCR",0.737548910269571,0.158640529545145,FALSE +"transcriptomics","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.21463,-0.768,0.793,15652,1,"SMAD7, TFDP1, RHOA, BMPR2, SMAD5, PITX2, BMP8B, PPP2CB, PPP2R1B, ID3, SMAD4, SKP1, SMURF2, BMPR1A, INHBE, SMAD9, BMP8A, ID2, TGFB1, CDKN2B, E2F5, ROCK2, BMP6, SMAD2",0.100726812682396,0,FALSE +"transcriptomics","Log2FC","KEGG_THYROID_CANCER",0.39121,1.13,0.263,3392,0.706,"CDH1, RXRA, MAPK3, RXRB, PPARG, BRAF, TCF7L1",0.580044251510242,0.151195298948196,FALSE +"transcriptomics","Log2FC","KEGG_TIGHT_JUNCTION",0.33254,0.971,0.509,4350,0.873,"EPB41L1, PRKCD, AMOTL1, MYH14, CLDN8, CGN, CLDN9, CLDN7, CLDN4, F11R, TJP3, CRB3, TJP2, PRKCH, LLGL2, CLDN18, PRKCI, PARD6B, PATJ, CLDN11, CTTN, EXOC4, CLDN23, CLDN3, SRC, MYH15, MYL9, EXOC3, MAGI1, PRKCZ, OCLN",0.293282217663241,0.0589857562944303,FALSE +"transcriptomics","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.43206,1.24,0.16,6260,0.758,"TLR5, TRAF6, MAPK13, PIK3R2, IRF5, LBP, IRF3, TOLLIP, CXCL10, IKBKB, MAPK3, TLR3, IFNB1, PIK3CA, MYD88, FADD, CXCL11, CCL5, CD40, IL12B, CXCL9, TAB1, RELA, TLR1, MAPK11, IKBKE, IL6, TLR2, MAP3K8, IRAK4, TIRAP, TICAM1, PIK3R3, STAT1, IL12A, RAC1, TAB2, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB, NFKBIA, FOS, IRF7",0.795880017344075,0.120330794367946,FALSE +"transcriptomics","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",0.25994,0.765,0.827,5698,1,"CAT, CYP1B1, GCDH, KMO, EHHADH, IL4I1, CYP1A1, MAOA, IDO1, HAAO, OGDHL",0.0824944904474534,0,FALSE +"transcriptomics","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",0.35999,1.05,0.372,1965,0.765,"PRKCD, HK2, PIK3R2, CACNA1D, SOCS1, GCK, IKBKB, MAPK3, INSR, PIK3CA",0.429457060118102,0.116338564846382,FALSE +"transcriptomics","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",-0.22684,-0.768,0.784,16990,1,"PRF1, PTPRN, HSPD1",0.105683937315562,0,FALSE +"transcriptomics","Log2FC","KEGG_TYROSINE_METABOLISM",0.48583,1.41,0.0488,2773,0.629,"ADH7, ALDH3B2, HEMK1, TH, ALDH1A3, ALDH3B1, COMT, AOC2, GSTZ1, NAA80, LCMT1",1.31158017799729,0.201349354554731,FALSE +"transcriptomics","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.29483,0.845,0.714,6624,1,"PAK6, CBLC, VAV1, MAPK13, PIK3R2, VAV3, DLG1, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, NCK2, CBLB, PLCG1, RELA, CHP1, MAPK11, PPP3CA, PAK2, LCK, MAP3K8, CSF2, PIK3R3, CD4, NCK1, PAK1, PAK4, MAPK1, MAP2K7, NFATC1, PIK3R5, PIK3CB, NFKBIA, GSK3B, FOS, NFATC4, GRB2, CHP2",0.146301788223826,0,FALSE +"transcriptomics","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29203,0.84,0.732,6099,1,"CBLC, UBOX5, ITCH, UBA7, TRAF6, UBE2H, PPIL2, SOCS1, FBXO2, SMURF1, PML, MAP3K1, FBXW7, UBE2L6, RHOBTB2, HERC1, HERC3, ANAPC2, CUL7, UBE2D4, CBLB, FBXO4, RNF7, MID1, SYVN1, UBA6, FBXW8, UBR5, UBE2C, PIAS3, KLHL13, UBE3B, UBE2W, HUWE1, NEDD4L, UBE2F, TRIM32, UBE2Q1, WWP2, DDB1, SIAH1, FZR1, UBE4A, UBE2E1, UBE3C, DET1, UBE2O, UBE2E2, STUB1, UBA3, ANAPC11, UBE2M, UBE2Z",0.135488918941608,0,FALSE +"transcriptomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.54815,-1.93,0.00901,13596,0.141,"VARS2, LARS2, BCAT1, PDHA1, IARS2",2.04527520902094,0.85078088734462,TRUE +"transcriptomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.42231,1.22,0.176,3822,0.694,"MCCC1, ACAA1, HIBADH, ACAD8, ALDH6A1, ABAT, HMGCL, HMGCS1, MCEE, ACADS, EHHADH, PCCB, IL4I1, AUH",0.75448733218585,0.158640529545145,FALSE +"transcriptomics","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.28813,0.843,0.705,4348,1,"PRKCD, PLA2G12A, KCNMB3, CACNA1D, PLA2G6, CALML3, PLA2G4B, ADORA2B, MAPK3, ADORA2A, PPP1CA, PRKCH, ADCY5, CYP4A22, PPP1CB, ADCY4, PLA2G10, PLA2G4E, BRAF, ADCY6, MYL9, PLA2G2C, EDNRA, KCNMB4, GNAS, GNAQ",0.151810883008601,0,FALSE +"transcriptomics","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.27394,0.798,0.794,7785,0.999,"DYNLL2, AQP3, RAB5B, ARHGDIB, ADCY6, CREB3L4, GNAS, DYNC2LI1, DCTN5, CREB3L3, PRKACA, CREB3L2, RAB11B, RAB5C, CREB5, CREB3L1, CREB3, ADCY9, ADCY3, NSF, CREB1, RAB11A, PRKACG, DCTN1",0.100179497572904,0.000434511774017692,FALSE +"transcriptomics","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.37587,1.09,0.31,5894,0.754,"PLA2G12A, MAPK13, PIK3R2, PLCG2, RAC2, PLA2G6, PLA2G4B, NOS3, HSPB1, MAPK3, PIK3CA, PLA2G10, PLA2G4E, MAPKAPK3, PLCG1, SPHK2, PXN, SRC, CHP1, MAPK11, PPP3CA, PLA2G2C, BAD, VEGFA, PIK3R3, SPHK1, MAPKAPK2, RAC1, MAPK1, NFATC1, PIK3R5, PIK3CB",0.508638306165727,0.122628654130226,FALSE +"transcriptomics","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",0.35881,1.03,0.379,7679,0.784,"ERO1A, PLCG2, ATP6V1C2, TJP2, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP6AP1, KDELR3, PLCG1, PDIA4, GNAS, TCIRG1, KCNQ1, ATP6V1G1, SEC61G, ATP6V0A4, PRKACA, KDELR2, ATP6V1C1, TJP1, ATP6V1E1, ADCY9, ADCY3, SEC61B, ATP6V0C, PRKACG, ATP6V1E2, ATP6V0E2",0.421360790031928,0.105683937315562,FALSE +"transcriptomics","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.26233,0.758,0.85,3633,0.983,"MYH14, ITGB2, RAC2, DAG1, CD40, EIF4G1, CAV1, MYH15",0.0705810742857073,0.00744648216786438,FALSE +"transcriptomics","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.25146,0.722,0.896,2541,1,"WNT3A, WNT9A, TBL1XR1, WNT7B, DAAM1, FZD10, PORCN, WNT7A, RAC2, SENP2, WNT4, FRAT1, CTNNBIP1, DVL3, CAMK2G, FRAT2, CSNK1E, WNT10A, LRP5, CSNK1A1, EP300, VANGL2",0.0476919903378748,0,FALSE +"proteomics","Log2FC","KEGG_ABC_TRANSPORTERS",-0.56716,-1.64,0.0417,8609,0.499,"ABCC5, ABCA1, ABCG1, ABCA10, ABCB1, ABCC10, ABCB7, ABCB5, ABCC1, ABCC4, ABCC6, ABCB4, ABCB10, ABCA7, ABCA3, ABCA13, ABCC2, ABCB11",1.37986394502624,0.30189945437661,FALSE +"proteomics","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.42626,1.21,0.202,2845,0.592,"PIK3CD, RARA, RUNX1, LEF1, CCND1, KRAS, NRAS, FLT3, PIK3R2, PIK3CA, STAT3, IKBKB, HRAS, EIF4EBP1, MAPK3, GRB2, RPS6KB2, SOS2, TCF7L1, MAPK1",0.694648630553376,0.22767829327708,FALSE +"proteomics","Log2FC","KEGG_ADHERENS_JUNCTION",0.47199,1.33,0.131,1296,0.6,"RAC2, NECTIN4, CDH1, SNAI2, CTNND1, ACTN3, CTNNA1, NECTIN1, CTNNA2, CTNNB1, BAIAP2, ERBB2, RAC3, EP300, LMO7, PTPN6, PTPRF, EGFR, LEF1",0.882728704344236,0.221848749616356,FALSE +"proteomics","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.31768,0.895,0.589,2689,0.966,"CD36, RXRA, RXRG, IRS1, ACSL4, ACSL1, PRKCQ, ACSL6, SLC2A1, ACSL5, STAT3, IKBKB, NFKBIA, PRKAB2, ACSL3",0.229884705212898,0.0150228735845067,FALSE +"proteomics","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.24638,0.704,0.866,2010,1,"GLUL, ABAT, GLUD2, GFPT1, GPT2",0.0624821079826534,0,FALSE +"proteomics","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.56793,1.61,0.0442,3523,0.604,"SCNN1A, ATP1A2, PIK3CD, IRS1, PDPK1, KRAS, HSD11B2, PIK3R2, PIK3CA, MAPK3, SCNN1B, MAPK1, SFN, ATP1A3, ATP1A4, ATP1A1, PRKCG",1.35457773065091,0.218963061378868,FALSE +"proteomics","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.58978,1.66,0.0378,2132,0.778,"FADS2, PLA2G12A, PLA2G2A, ACOX1, ACOX3",1.42250820016277,0.109020403010311,FALSE +"proteomics","Log2FC","KEGG_ALZHEIMERS_DISEASE",-0.26665,-0.77,0.751,8102,0.905,"PSEN1, NDUFV1, UQCRC1, COX7A2, NDUFA6, ERN1, NDUFC1, BAD, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, NDUFA2, NDUFS3, ATP5F1D, MAPT, ATP5PF, NDUFB4, HSD17B10, NDUFA3, ITPR2, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, IDE, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, ATP5F1C, PPP3CC, ITPR1, PLCB2, ATP5F1B, ATP5PB, ATP5PD, NDUFB2, ATP5MC2, BACE2, CASP7, PLCB4, PSEN2",0.124360062995832,0.0433514207947967,FALSE +"proteomics","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.38256,-1.1,0.308,7208,0.573,"AARS2, FARSB, FARS2, SARS2, LARS2, DARS2, YARS2, MTFMT, EARS2, WARS2, RARS2",0.511449283499556,0.24184537803261,FALSE +"proteomics","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.27352,0.759,0.793,2412,1,"HK1, MPI, NPL, RENBP, PGM1, NAGK, GMPPA, GFPT1, HK2, GALT, PGM2, GALE",0.100726812682396,0,FALSE +"proteomics","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.34389,-1.01,0.395,10318,0.62,"NEFM, MAP2K6, MAPK11, SOD1, NEFL, PRPH, PRPH2, NEFH",0.40340290437354,0.207608310501746,FALSE +"proteomics","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.32022,0.897,0.599,3597,0.975,"CTSS, IFI30, CD74, CALR, LGMN, HSPA6, TAPBP, HSPA1A, PSME2, CREB1, PSME1, CTSB",0.222573177610689,0.0109953843014632,FALSE +"proteomics","Log2FC","KEGG_APOPTOSIS",0.23693,0.675,0.897,2534,1,"IL1R1, BCL2, IL1RAP, ENDOD1, PIK3CD, CASP10, MYD88, PPP3R1, PPP3CA, PPP3CB, PPP3R2, PIK3R2, TP53, CASP6, PIK3CA, IKBKB, PRKAR1B, CAPN2, NFKBIA, ENDOG",0.0472075569559079,0,FALSE +"proteomics","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",0.4694,1.31,0.153,2120,0.557,"GGT5, PTGS2, PLA2G12A, EPHX2, ALOX5, GPX6, GPX7, PTGES, PLA2G2A, GPX1, GGT7, GPX3",0.815308569182401,0.254144804826271,FALSE +"proteomics","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34932,0.98,0.438,2841,0.894,"GLUL, OAT, PRODH, PRODH2, GATM, ARG1, NOS3, CKMT1A, CKMT2, GLUD2, NOS1, P4HA2, NAGS, ARG2, P4HA1, PYCR3, MAOA, ASL, OTC, ALDH18A1",0.3585258894959,0.0486624812040823,FALSE +"proteomics","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.33473,0.934,0.498,1866,0.938,"ITGB6, ITGB8, ACTN3, CTNNA1, ITGB4, CTNNA2, CTNNB1, DSC2, ITGA2, ITGA11, SGCG, LEF1, ITGA4, CACNA1F, GJA1, ITGA3, PKP2",0.302770657240282,0.0277971616209356,FALSE +"proteomics","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.61182,-1.83,0.0219,7847,0.343,"ALDH9A1, ALDH1B1, ALDH3A2, ALDH2, ALDH7A1",1.65955588515988,0.464705879957229,FALSE +"proteomics","Log2FC","KEGG_AXON_GUIDANCE",0.46405,1.32,0.135,2598,0.577,"RAC2, PAK5, PAK6, NGEF, EPHA1, EPHB2, RGS3, ROBO2, NTN4, SEMA4B, NFATC4, EFNB2, EFNA1, SEMA7A, RAC3, PLXNB2, PPP3R1, SEMA3A, SEMA3C, PPP3CA, PPP3CB, PLXNA2, EPHB4, PPP3R2, EPHA4, SEMA4D, KRAS, NRAS, SLIT2, EPHB3, EPHB1, RHOA, NFATC1, SLIT1, SLIT3, RAC1, MET, LIMK2, HRAS, MAPK3, PLXNA1, ABLIM1, NFATC3, NTN1, NFATC2, RHOD",0.869666231504994,0.238824186844269,FALSE +"proteomics","Log2FC","KEGG_BASAL_CELL_CARCINOMA",-0.25512,-0.732,0.811,10364,0.917,"WNT10A, GLI2, GLI3",0.090979145788844,0.0376306643299789,FALSE +"proteomics","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.41284,-1.22,0.214,7232,0.5,"GTF2A1, STON1, GTF2E2, TAF10, TBP, GTF2H3, GTF2A2, GTF2F2, GTF2H4, GTF2H1, TAF12, GTF2H2, GTF2F1, TAF13, TBPL1",0.669586226650809,0.301029995663981,FALSE +"proteomics","Log2FC","KEGG_BASE_EXCISION_REPAIR",-0.24796,-0.718,0.793,9965,0.926,"POLL, NTHL1, MUTYH",0.100726812682396,0.0333890133180656,FALSE +"proteomics","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.28968,-0.846,0.648,7434,0.779,"SRM, ECHS1, MLYCD, ALDH9A1, EHHADH, ALDH1B1, ALDH3A2, ALDH2, ALDH7A1",0.188424994129407,0.108462542327436,FALSE +"proteomics","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.35293,-1.03,0.382,9642,0.626,"HACD1, YOD1, PECR, ACOT7, ELOVL2",0.417936637088291,0.20342566678957,FALSE +"proteomics","Log2FC","KEGG_BLADDER_CANCER",0.463,1.32,0.138,2596,0.577,"CDH1, VEGFA, THBS1, ERBB2, VEGFC, EGFR, CDK4, CCND1, KRAS, NRAS, CDKN1A, MMP2, TP53, HRAS, MAPK3, CDKN2A",0.860120913598763,0.238824186844269,FALSE +"proteomics","Log2FC","KEGG_BUTANOATE_METABOLISM",0.29975,0.848,0.662,891,0.999,"ABAT, HMGCS1, ACSM3, BDH2",0.1791420105603,0.000434511774017692,FALSE +"proteomics","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.52452,1.47,0.0703,2561,0.621,"RAC2, DAPP1, CARD11, NFATC4, PIK3CD, RAC3, LYN, CD79A, PTPN6, PIK3AP1, PPP3R1, VAV1, PPP3CA, VAV2, PPP3CB, PPP3R2, KRAS, NRAS, CD81, NFATC1, PIK3R2, RAC1, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, VAV3, GRB2, NFATC3, NFATC2, SOS2",1.15304467498018,0.20690839982342,FALSE +"proteomics","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.24843,0.694,0.888,1708,1,"TNNC1, ERBB3, GNA15, TNNC2, NOS3, ERBB2, ERBB4, ATP2A3, PPP3R1, EGFR, PPP3CA, PPP3CB, PPP3R2, NOS1, PTK2B, CACNA1F, CACNA1A",0.051587034221399,0,FALSE +"proteomics","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.35378,0.998,0.432,840,0.878,"TNNC1, MYH7, ATP1A2, SLC9A1",0.364516253185088,0.0565054840938974,FALSE +"proteomics","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.48094,1.35,0.128,793,0.579,"CLDN18, CLDN4, CLDN7, CDH15, CDH3, CDH5, SDC4, ITGAL, SDC1, ITGB8, ITGB2, CLDN3, CDH1, F11R, CLDN6, VCAN, JAM2, SDC2, NECTIN1, SDC3, CD274, ICAM2",0.892790030352132,0.237321436272564,FALSE +"proteomics","Log2FC","KEGG_CELL_CYCLE",0.18042,0.51,0.998,2700,1,"FZR1, CDC6, WEE1, EP300, CDC7, CHEK2, ANAPC11, CDKN1C, CDK4, SKP2, CCND1, CCNB1, BUB1, CDKN1A, CCNA2, RBL1, CREBBP, TP53, PCNA, CHEK1, BUB1B, CDKN2A, HDAC1, ZBTB17",0.000869458712628891,0,FALSE +"proteomics","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.28479,-0.834,0.658,10271,0.79,"PLCB4, CXCL10, DOCK2, ADCY6, GNG7, SHC4, CCR10, CCR9, WAS, CXCL5, RASGRP2, CXCL14",0.181774106386044,0.102372908709559,FALSE +"proteomics","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.23803,0.668,0.922,2652,0.989,"PIK3CD, MECOM, RUNX1, CDK4, CCND1, KRAS, NRAS, CDKN1A, BCR, PIK3R2, TP53, PIK3CA, CTBP1, IKBKB, HRAS, MAPK3, NFKBIA, CBLB, GRB2, SOS2, CDKN2A, HDAC1",0.0352690789463706,0.0048037084028206,FALSE +"proteomics","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.51999,1.46,0.0816,2428,0.603,"BHLHE41, PER2, NR1D1, CSNK1E, ARNTL",1.08830984124614,0.219682687859849,FALSE +"proteomics","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.18745,-0.537,0.992,2896,1,"IDH1, SUCLG2, ACO1, DLD, ACLY, ACO2, DLST, PCK1, MDH2, MDH1, SDHA, SUCLG1, OGDHL, DLAT, OGDH, PC, SUCLA2, IDH3B, SDHB, CS, SDHC, IDH3A, PDHB, PDHA1, IDH3G, FH, SDHD, PCK2",0.00348832784582135,0,FALSE +"proteomics","Log2FC","KEGG_COLORECTAL_CANCER",0.32298,0.918,0.522,2210,0.965,"RAC2, BCL2, CTNNB1, PIK3CD, RAC3, LEF1, CCND1, KRAS, RHOA, PIK3R2, TP53, RAC1, PIK3CA",0.282329496997738,0.0154726866562074,FALSE +"proteomics","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.403,1.13,0.261,944,0.723,"CFI, CFB, SERPINA1, TFPI, FGG, FGB, SERPINA5, MASP1, PLAT, PLAU, SERPINC1, F3",0.583359492661719,0.140861702705469,FALSE +"proteomics","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.39207,-1.14,0.242,8054,0.565,"APIP, GOT1, MAT2B, SDS, GOT2, CBS, MAT2A, MAT1A, MTAP, AMD1, CDO1",0.616184634019569,0.247951552180562,FALSE +"proteomics","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.46198,-1.37,0.124,10106,0.559,"TNFRSF10A, TGFB1, BMPR2, CXCL10, INHBA, TNFRSF19, ACVR2A, CD70, TNFSF9, TGFB2, CD40, BMPR1A, TNFRSF10C, CCR10, CCR9, IL1A, IFNAR2, CXCL5, INHBE, CXCL14, PDGFRA",0.906578314837765,0.252588192113577,FALSE +"proteomics","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.16559,0.457,0.998,2883,1,"CASP1, RIPK3, DDX58, IL18, IKBKB, NFKBIA, IKBKE, IL1B",0.000869458712628891,0,FALSE +"proteomics","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",-0.30863,-0.921,0.504,10453,0.695,"ADCY6, TGFB2, TPM2, LAMA2, CACNA2D2, SGCD, CACNA2D1, ITGA10, DES",0.297569463554475,0.158015195409886,FALSE +"proteomics","Log2FC","KEGG_DNA_REPLICATION",-0.20491,-0.606,0.968,2252,0.988,"PCNA, LIG1, RFC5, POLD4, RFC2, RFC3, POLE, RFC1, RPA3, POLE4, POLD3, RFC4, MCM4, POLE3, MCM6, POLD1, MCM5, MCM7, RPA2, SSBP1, RNASEH2A, MCM3, POLE2, POLD2, FEN1, PRIM1, RPA1, MCM2, DNA2, RNASEH1, PRIM2, POLA1, POLA2, RNASEH2C, RNASEH2B",0.0141246426916063,0.00524305541237188,FALSE +"proteomics","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.55702,1.54,0.0554,2561,0.546,"ETS2, ETV6, EGFR, NOTCH3, KRAS, PIWIL2, MAPK3, GRB2, SOS2",1.25649023527157,0.262807357295263,FALSE +"proteomics","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.35951,1.01,0.407,1430,0.862,"FMO5, GSTA5, ADH4, ADH7, FMO2, FMO4, MGST2, ALDH1A3, MGST1, ALDH3B1, FMO3",0.39040559077478,0.0644927341752872,FALSE +"proteomics","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.42011,-1.27,0.169,9395,0.538,"GMPS, CYP3A5, UCK2, UMPS, NAT2, CYP3A7",0.772113295386326,0.269217724333611,FALSE +"proteomics","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.43662,1.21,0.204,1082,0.592,"ITGB6, TNC, SDC4, CD36, SDC1, ITGB8, ITGB4, SDC2, LAMC2, LAMB3, THBS1, SDC3, CD47, ITGA2, ITGA11, LAMA3, LAMA4",0.690369832574101,0.22767829327708,FALSE +"proteomics","Log2FC","KEGG_ENDOCYTOSIS",0.2991,0.83,0.675,2726,1,"EPN3, PSD4, ERBB3, ARRB1, CHMP2B, ASAP3, RAB11FIP1, RAB11FIP4, ERBB4, DNAJC6, ARAP3, EGFR, GRK2, AGAP1, TRAF6, PRKCZ, AGAP2, RAB22A, EHD2, PRKCI, PARD6G, ITCH, ARF6, RAB11B, RAB31, RAB11A, CHMP4C, MET, LDLRAP1, CHMP4A, CHMP4B, CHMP2A, CLTCL1, PARD6B, HRAS, EPS15, CBLB, IGF1R, HSPA6, VPS37B, RAB5B, PARD6A, EPN1",0.170696227168975,0,FALSE +"proteomics","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.50929,1.44,0.0828,2624,0.611,"CDH1, CTNNA1, CTNNA2, CTNNB1, ERBB2, PIK3CD, EGFR, LEF1, PDPK1, CCND1, KRAS, NRAS, PIK3R2, TP53, PIK3CA, HRAS, MAPK3, GRB2, SOS2, TCF7L1",1.08196966321512,0.213958789757446,FALSE +"proteomics","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.31162,0.882,0.569,1141,0.985,"CXCL1, F11R, JAM2, MAPK12, MAPK13, LYN, EGFR",0.244887733604929,0.00656376950238827,FALSE +"proteomics","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.41192,1.12,0.282,2561,0.698,"EREG, ERBB3, AREG, PAK5, PAK6, TGFA, ERBB2, PIK3CD, ERBB4, EGFR, GAB1, KRAS, NRAS, CDKN1A, PIK3R2, PIK3CA, HRAS, EIF4EBP1, MAPK3, CAMK2D, ABL2, CBLB, GRB2, RPS6KB2, SOS2",0.549750891680639,0.156144577376839,FALSE +"proteomics","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.4815,1.35,0.123,2108,0.579,"LPCAT2, PLA2G12A, PAFAH2, PLA2G2A, LPCAT4, LPCAT1, PLPP3",0.910094888560602,0.237321436272564,FALSE +"proteomics","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.299,0.836,0.662,2361,1,"ADH4, ADH7, ACSL4, ACAA1, ACSL1, ACOX1, CPT2, ACSL6, ADH1C, ACOX3, ACADM, ACSL5, ACADS",0.1791420105603,0,FALSE +"proteomics","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.46449,1.3,0.156,2664,0.54,"RAC2, PRKCD, MAPK12, PIK3CD, MAPK13, PLA2G12A, RAC3, LYN, VAV1, LCP2, VAV2, PLA2G2A, PDPK1, KRAS, NRAS, PIK3R2, RAC1, PIK3CA, HRAS, MAPK3, VAV3, GRB2, SOS2, MAPK14",0.806875401645538,0.267606240177031,FALSE +"proteomics","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.3637,1.01,0.394,2557,0.862,"RAC2, PRKCD, AMPH, ASAP3, SCIN, PIK3CD, LYN, VAV1, GSN, MYO10, HCK, VAV2, MARCKS, MARCKSL1, PLA2G4F, ARF6, PTPRC, PIK3R2, PLPP3, RAC1, PIK3CA, LIMK2, MAPK3, VAV3, RPS6KB2",0.404503778174426,0.0644927341752872,FALSE +"proteomics","Log2FC","KEGG_FOCAL_ADHESION",0.29325,0.826,0.673,1355,0.998,"ITGB6, TNC, RAC2, BCL2, PAK5, PAK6, ITGB8, VEGFA, ACTN3, ITGB4, LAMC2, LAMB3, THBS1, CTNNB1, ERBB2, VEGFC, PIK3CD, RAC3, VAV1, ITGA2, ITGA11, LAMA3, LAMA4, EGFR, VAV2, PDPK1, CCND1",0.171984935776023,0.000869458712628891,FALSE +"proteomics","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.38519,1.09,0.304,2050,0.708,"ALPI, ALPP, ALPG, FPGS, PTS",0.517126416391246,0.149966742310231,FALSE +"proteomics","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.59056,1.64,0.0309,2113,0.705,"ALDOB, FBP1, ALDOC, PFKFB4, MTMR7, HK1, FBP2, PFKFB2, MPI, GMPPA, MTMR1, HK2",1.51004152057517,0.151810883008601,FALSE +"proteomics","Log2FC","KEGG_GALACTOSE_METABOLISM",0.35287,0.983,0.414,2908,0.903,"B4GALT1, HK1, PGM1, HK2, GAA, GALT, PGM2, GALE, UGP2, MGAM",0.382999658879101,0.0443122496864942,FALSE +"proteomics","Log2FC","KEGG_GAP_JUNCTION",-0.39068,-1.15,0.249,9590,0.564,"GNAI1, ITPR1, PLCB2, TUBA8, TUBA3C, TUBB6, GRM5, PLCB4, MAP2K5, ADCY6, TUBB2B, PDGFRA",0.603800652904264,0.248720896016658,FALSE +"proteomics","Log2FC","KEGG_GLIOMA",-0.32991,-0.968,0.426,10540,0.672,"CDK6, SHC4, PDGFRA",0.370590400897281,0.172630726946175,FALSE +"proteomics","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.28325,0.784,0.727,2603,1,"GGT5, GSTA5, MGST2, GPX6, GPX7, MGST1, GSTK1, GPX1, IDH2, GGT7, GPX3, MGST3, G6PD, ANPEP, GSTT2",0.138465589140962,0,FALSE +"proteomics","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.32775,0.901,0.55,2176,0.98,"LIPC, LPL, MGLL, LIPG, DGKA, DGKH, MBOAT2, DGKB, PLPP3, DGAT1",0.259637310505756,0.00877392430750515,FALSE +"proteomics","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.34171,0.973,0.439,3460,0.895,"PEMT, DGKA, LPCAT2, PLA2G12A, CDS1, DGKH, PLA2G2A, CHKA, LPCAT4, MBOAT2, LPCAT1, DGKB, LYPLA2, PLPP3, PISD, PCYT2, LPGAT1, GPD1L, MBOAT1, DGKZ, PLA2G4A, GPD2, CHKB, LPCAT3, DGKQ",0.357535479757879,0.048176964684088,FALSE +"proteomics","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.30658,-0.898,0.525,9064,0.714,"CBS, AGXT, ALAS1, PHGDH, PIPOX, PSAT1, MAOB, GLDC",0.279840696594043,0.146301788223826,FALSE +"proteomics","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.45991,1.3,0.152,881,0.54,"ALDOB, PGAM2, FBP1, ALDOC, ADH4, ADH7, GALM, HK1, FBP2, ACSS2, ALDH1A3",0.818156412055227,0.267606240177031,FALSE +"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.34596,-1.01,0.419,9904,0.62,"XYLT1, CSGALNACT2, CHST3, CHST7",0.377785977033705,0.207608310501746,FALSE +"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.34182,0.955,0.473,3070,0.911,"HS6ST2, HS6ST1, XYLT2, EXT2, EXT1, EXTL3",0.325138859262188,0.0404816230270017,FALSE +"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66613,1.85,0.0202,2887,0.771,"B4GALT1, FUT8, B4GALT3, ST3GAL1, B3GNT2, B4GALT4",1.69464863055338,0.112945621949043,FALSE +"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.43357,-1.24,0.181,9910,0.545,"HEXA, IDUA, ARSB, HYAL1",0.742321425130815,0.263603497723358,FALSE +"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.51004,-1.44,0.103,7952,0.644,"HEXB, ST3GAL5, HEXA, B4GALNT1",0.987162775294828,0.191114132640188,FALSE +"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.56837,1.6,0.0392,725,0.562,"B3GALNT1, B3GALT5",1.40671393297954,0.250263684430939,FALSE +"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.62329,1.74,0.0218,2178,0.895,"B3GNT3, FUT3, B4GALT1, B3GALT5, B4GALT3, ST3GAL4, B3GNT2",1.6615435063954,0.048176964684088,FALSE +"proteomics","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.25881,-0.746,0.767,8687,0.907,"PIGN, PIGQ, PIGB, PIGM, PIGX",0.115204636051019,0.0423927129399047,FALSE +"proteomics","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.16598,0.463,0.998,4328,1,"AFMID, GLYCTK, ACO1, ACO2, MDH2, MTHFD2L, MDH1, MTHFD1",0.000869458712628891,0,FALSE +"proteomics","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.23616,0.655,0.922,3427,0.993,"PRKCD, MAPK12, MAPK13, PLA2G12A, CGA, EGFR, PLA2G2A, KRAS, NRAS, PTK2B, CACNA1F, MAP3K1, MMP2, PLCB1, HRAS, MAPK3, CAMK2D, GRB2, SOS2, MAPK14, MAPK1, PLA2G4A, MMP14, GNA11, ADCY9, CDC42, CAMK2B, PLCB3, SOS1, ADCY5",0.0352690789463706,0.00305075150461883,FALSE +"proteomics","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.30481,-0.899,0.559,10364,0.725,"WNT10A, GLI2, GLI3",0.252588192113577,0.139661993429006,FALSE +"proteomics","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.29233,0.812,0.721,1843,0.992,"IL1R1, CD36, CD9, ITGA2, ITGA4, ITGA3, FLT3, CD33",0.142064735280571,0.00348832784582135,FALSE +"proteomics","Log2FC","KEGG_HISTIDINE_METABOLISM",-0.34944,-1.04,0.365,10443,0.638,"ALDH2, MAOB, ALDH7A1, ALDH3A1",0.437707135543525,0.195179321278838,FALSE +"proteomics","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",-0.38362,-1.13,0.277,9496,0.552,"RAD50, MUS81, MRE11, RAD52",0.557520230935551,0.258060922270801,FALSE +"proteomics","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.35692,-1.05,0.346,7298,0.634,"NDUFV2, COX7C, POLR2L, NDUFS4, SDHB, NDUFB5, POLR2I, COX4I1, POLR2A, SDHC, COX6B1, DCTN4, COX6A1, POLR2E, CYCS, DCTN2, DNAL1, TBP, NDUFV1, UQCRC1, COX7A2, NDUFA6, NDUFC1, POLR2H, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, SLC25A6, BAX, NDUFA2, DCTN1, TFAM, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, VDAC1, NDUFA3, HIP1, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, DNAH3, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, TGM2, ATP5F1C, SOD2, AP2A2, ITPR1, PLCB2, ATP5F1B, ATP5PB, SLC25A4, ATP5PD, NDUFB2, ATP5MC2, TBPL1, GRM5, PLCB4, BBC3, SOD1",0.460923901207223,0.197910742118267,FALSE +"proteomics","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.32547,-0.963,0.454,10552,0.667,"TGFB2, PRKAA2, TPM2, LAMA2, CACNA2D2, SGCD, CACNA2D1, ITGA10, DES",0.342944147142896,0.175874166083451,FALSE +"proteomics","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.25705,0.724,0.848,3346,1,"IMPA2, INPP4B, PIK3CD, PIP4K2C, ALDH6A1, PLCB1, PIK3C2B, PIK3CA, PI4KA, PLCD1, ISYNA1, INPP5B, INPP5A, PIP4K2A, PI4KB, SYNJ2, PLCB3",0.0716041477432862,0,FALSE +"proteomics","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.20113,0.566,0.981,2750,1,"FBP1, PIK3CD, HK1, FBP2, PTPRF, IRS1, PDPK1, KRAS, NRAS, PRKCZ, PYGB, PRKCI, EXOC7, MKNK1, PIK3R2, HK2, PIK3CA, PTPN1, PPP1R3D, IKBKB, PRKAR1B, HRAS, EIF4EBP1, MAPK3, RHEB, CBLB, GRB2, RPS6KB2, SOS2, PRKAB2, PYGL, GYS1",0.0083309926200515,0,FALSE +"proteomics","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.50265,-1.47,0.067,10060,0.64,"ICOSLG, TGFB1, CD40, CCR10, CCR9",1.17392519729917,0.193820026016113,FALSE +"proteomics","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.27492,0.779,0.769,2561,1,"SPRY2, LIFR, PIK3CD, EP300, PTPN6, STAT2, IL13RA1, IFNGR1, CCND1, IRF9, STAT1, OSMR, STAT6, SPRY1, CREBBP, PIK3R2, JAK1, PIAS3, PIK3CA, STAT3, CBLB, GRB2, SOS2",0.114073660198569,0,FALSE +"proteomics","Log2FC","KEGG_LEISHMANIA_INFECTION",0.37967,1.06,0.326,2883,0.765,"ITGB2, PTGS2, MAPK12, MAPK13, MYD88, PTPN6, IFNGR1, STAT1, ITGA4, TRAF6, MARCKSL1, JAK1, MAPK3, NFKBIA, MAPK14, C3, MAPK1, IL1B",0.486782399932061,0.116338564846382,FALSE +"proteomics","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.50535,1.4,0.109,809,0.575,"CLDN18, CLDN4, CLDN7, RAC2, CDH5, ITGAL, ITGB2, CLDN3, F11R, CLDN6, CTNND1, ACTN3, CTNNA1, JAM2, MAPK12, CTNNA2, CTNNB1, PIK3CD, MAPK13",0.962573502059376,0.24033215531037,FALSE +"proteomics","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.6513,-1.97,0.00756,7847,0.296,"ALDH9A1, EHHADH, ALDH1B1, ALDH3A2, YOD1, ALDH2, ALDH7A1, NAA80",2.12147820449879,0.528708288941061,FALSE +"proteomics","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",-0.568,-1.67,0.0422,10332,0.518,"PLA2G6, CYP3A7",1.37468754903833,0.285670240254767,FALSE +"proteomics","Log2FC","KEGG_LONG_TERM_DEPRESSION",-0.22631,-0.665,0.946,9590,0.989,"GNAI1, ITPR1, PLCB2, GRM5, PLCB4, PLA2G6, PPP1R17",0.0241088635982073,0.0048037084028206,FALSE +"proteomics","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.24302,0.676,0.913,2407,1,"EP300, PPP3R1, PPP3CA, PPP3CB, PPP3R2, KRAS, NRAS, RPS6KA1, CREBBP, RPS6KA6, PLCB1, RPS6KA2, HRAS, MAPK3, CAMK2D",0.039529222465701,0,FALSE +"proteomics","Log2FC","KEGG_LYSINE_DEGRADATION",-0.35898,-1.05,0.348,10138,0.634,"TMLHE, PIPOX, ALDH2, ALDH7A1, AADAT, BBOX1",0.458420756053419,0.197910742118267,FALSE +"proteomics","Log2FC","KEGG_LYSOSOME",0.25134,0.697,0.881,1651,1,"CTSE, CTSH, AP1M2, CTSS, ACP5, LAMP3, NEU1, NPC2, NAPSA, CTSA, SLC11A2, GM2A, AP1B1, AP1S1, FUCA1, SGSH",0.0550240915879521,0,FALSE +"proteomics","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",-0.30167,-0.869,0.617,9929,0.76,"TGFB3, DUSP16, MAPK8, FLNC, DDIT3, MKNK2, FGFR1, TGFB1, MAP2K5, PLA2G6, MAP2K6, MAPK11, MYC, NFKB2, TGFB2, ATF4, RELB, IL1A, CACNA2D2, DUSP4, CACNA2D1, MEF2C, FGF13, FGF2, RASGRP2, PDGFRA",0.209714835966758,0.119186407719209,FALSE +"proteomics","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.73187,-2.15,0,9747,0.299,"HNF1A, HNF4A, NEUROD1, GCK, MNX1, PAX6",Inf,0.52432881167557,FALSE +"proteomics","Log2FC","KEGG_MELANOGENESIS",0.30698,0.863,0.613,3523,0.99,"GNAO1, TYR, CTNNB1, WNT5B, EP300, LEF1, KRAS, NRAS, WNT11, DVL1, CREBBP, CREB3L2, CREB3L1, PLCB1, HRAS, MAPK3, CAMK2D, WNT5A, TCF7L1, MAPK1, GNAI2, DVL3, GNAI3, ADCY9, CAMK2B, PLCB3, ADCY5, CREB1, PRKCG",0.212539525481585,0.00436480540245009,FALSE +"proteomics","Log2FC","KEGG_MELANOMA",-0.43,-1.27,0.17,10540,0.538,"CDK6, FGF13, FGF2, PDGFRA",0.769551078621726,0.269217724333611,FALSE +"proteomics","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.42413,-1.23,0.212,10663,0.521,"AKR1C1, GSTM2, AKR1C3, AKR1C2, GSTA4, ALDH3A1, CYP3A7",0.673664139071249,0.283162276700476,FALSE +"proteomics","Log2FC","KEGG_MISMATCH_REPAIR",0.43847,1.21,0.205,4177,0.592,"PCNA, LIG1, MLH3, RFC5, POLD4, EXO1, RFC2, RFC3, RFC1, RPA3, POLD3, RFC4",0.688246138944246,0.22767829327708,FALSE +"proteomics","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.42655,1.22,0.195,2845,0.62,"VEGFA, VEGFC, PIK3CD, CAB39, PDPK1, RPS6KA1, PIK3R2, RPS6KA6, HIF1A, PIK3CA, RPS6KA2, EIF4EBP1, MAPK3, RHEB, RPS6KB2, RICTOR, RPS6KA3, MAPK1",0.709965388637482,0.207608310501746,FALSE +"proteomics","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.48135,1.36,0.116,2561,0.636,"RAC2, ITGAL, ITGB2, LCK, RAET1L, ULBP2, NFATC4, SH3BP2, ICAM2, PIK3CD, RAC3, PTPN6, PPP3R1, VAV1, LCP2, PPP3CA, VAV2, IFNGR1, PPP3CB, PPP3R2, KRAS, NRAS, PTK2B, ICAM1, NFATC1, PIK3R2, RAC1, PIK3CA, HRAS, MAPK3, VAV3, GRB2, NFATC3, NFATC2, SOS2",0.935542010773082,0.196542884351586,FALSE +"proteomics","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.21798,-0.625,0.932,8815,1,"TACR1, LEPR, F2R, P2RY11, CTSG, GRM5, PRSS1",0.0305840876460186,0,FALSE +"proteomics","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.31617,0.88,0.593,2672,0.962,"ARHGDIB, BCL2, TP73, PRKCD, ZNF274, MAPK12, PIK3CD, MAPK13, IRS1, GAB1, PDPK1, MAP3K5, TRAF6, KRAS, NRAS, RPS6KA4, MAP3K1, RPS6KA1, MAGED1, RHOA, PIK3R2, RPS6KA6, TP53, RAC1, NTRK2, PIK3CA, IKBKB, RPS6KA2, HRAS, MAPK3, CAMK2D, NFKBIA, GRB2, SOS2, FRS2, MAPK14, SORT1",0.226945306635737,0.0168249279621871,FALSE +"proteomics","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.48857,-1.4,0.108,9003,0.675,"NMNAT3, NAMPT, NNT, NT5C, CD38, BST1, NNMT",0.96657624451305,0.170696227168975,FALSE +"proteomics","Log2FC","KEGG_NITROGEN_METABOLISM",-0.39831,-1.16,0.263,9727,0.564,"CA14, CA2, CA12, CPS1, CA8",0.580044251510242,0.248720896016658,FALSE +"proteomics","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.43448,1.23,0.191,2883,0.615,"CASP5, CXCL1, MAPK12, TRIP6, MAPK13, CASP1, TRAF6, IL18, IKBKB, MAPK3, NAIP, NFKBIA, TAB3, MAPK14, CASP8, CCL13, MAPK1, IL1B",0.718966632752272,0.211124884224583,FALSE +"proteomics","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.71762,-2.13,0.00549,9253,0.171,"NHEJ1, PRKDC, RAD50, MRE11, POLL",2.26042765554991,0.767003889607846,TRUE +"proteomics","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.41063,1.15,0.269,2596,0.694,"RXRA, RXRG, TGFA, ERBB2, PIK3CD, EGFR, CDK4, PDPK1, CCND1, KRAS, NRAS, PIK3R2, TP53, PIK3CA, HRAS, MAPK3, GRB2, SOS2, CDKN2A",0.570247719997592,0.158640529545145,FALSE +"proteomics","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.34018,0.956,0.495,3178,0.924,"DTX3L, EP300, JAG1, NOTCH3, NCOR2, DVL1, CREBBP, DTX2, CTBP1, NUMB, HDAC1, MAML3, DVL3, RBPJ, JAG2",0.305394801066431,0.0343280287798933,FALSE +"proteomics","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.17811,-0.529,0.992,1956,0.991,"ERCC5, PCNA, RAD23B, LIG1, RFC5, POLD4, RFC2, RFC3, POLE, RFC1, RPA3, CUL4A, POLE4, POLD3, RFC4, RBX1, CETN2, POLE3, DDB1, MNAT1, POLD1, ERCC6, RAD23A, ERCC4, RPA2, POLE2, POLD2, RPA1, CDK7, GTF2H5, ERCC3, DDB2, CUL4B, GTF2H3, ERCC2, CCNH, GTF2H4, GTF2H1, GTF2H2, ERCC1, ERCC8, XPC, XPA",0.00348832784582135,0.00392634551472468,FALSE +"proteomics","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.47511,1.35,0.116,836,0.579,"MAN1C1, MGAT4A, ST6GAL1, B4GALT1, FUT8",0.935542010773082,0.237321436272564,FALSE +"proteomics","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",-0.37643,-1.13,0.289,9870,0.552,"CNGB1, PDE1C",0.539102157243452,0.258060922270801,FALSE +"proteomics","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.53605,-1.57,0.0683,8075,0.503,"MTHFD1L, ATIC, MTHFD2, MTHFS, MTFMT, TYMS, MTHFR, GART, ALDH1L1",1.16557929631847,0.298432014944073,FALSE +"proteomics","Log2FC","KEGG_OOCYTE_MEIOSIS",0.19709,0.561,0.973,3300,1,"MAPK12, PPP3R1, ANAPC11, PPP3CA, AR, AURKA, PPP3CB, PPP2R5E, CCNB1, PPP3R2, PPP2R5B, BUB1, RPS6KA1, RPS6KA6, RPS6KA2, MAPK3, CAMK2D, IGF1R, RPS6KA3, MAPK1, BTRC, YWHAB, ADCY9, PKMYT1, CAMK2B",0.0118871597316481,0,FALSE +"proteomics","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",-0.2091,-0.614,0.942,7256,1,"FUCA2, MAN2B1, HEXB, MAN2B2, AGA, MAN2C1, HEXA",0.0259490972071227,0,FALSE +"proteomics","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.46085,-1.37,0.135,7298,0.559,"NDUFV2, COX7C, NDUFS4, SDHB, NDUFB5, COX15, ATP6V1A, COX4I1, SDHC, COX6B1, COX6A1, NDUFV1, UQCRC1, ATP6V1B2, COX7A2, NDUFA6, NDUFC1, PPA1, ATP6V0A2, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, NDUFA2, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, NDUFA11, NDUFA3, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, ATP5MG, SDHD, NDUFS8, NDUFS2, ATP5F1C, ATP5F1B, ATP5PB, ATP5PD, NDUFB2, ATP5ME, ATP5MC2, COX11",0.869666231504994,0.252588192113577,FALSE +"proteomics","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.59998,1.71,0.023,1847,0.775,"GCNT3, GALNT3, GALNT12, GALNT6, ST6GALNAC1, GALNT8, GALNT13, GALNT7, B4GALT5, GALNT2, GALNT15, GALNT5, C1GALT1C1, GALNT4, ST3GAL1",1.63827216398241,0.11069829749369,FALSE +"proteomics","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.29693,0.85,0.656,1726,1,"TP73, SERPINB5, SESN3, THBS1, CHEK2, CDK4, CCND1, RCHY1, CCNB1, CDKN1A, EI24",0.18309616062434,0,FALSE +"proteomics","Log2FC","KEGG_PANCREATIC_CANCER",0.39919,1.12,0.274,2405,0.698,"RAC2, VEGFA, TGFA, ERBB2, VEGFC, PIK3CD, RAC3, EGFR, CDK4, RALB, CCND1, STAT1, KRAS, PIK3R2, TP53, JAK1, RAC1, PIK3CA, STAT3, IKBKB, MAPK3",0.562249437179612,0.156144577376839,FALSE +"proteomics","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.26633,0.732,0.805,2657,1,"BCAT2, PANK1, DPYD",0.0942041196321315,0,FALSE +"proteomics","Log2FC","KEGG_PARKINSONS_DISEASE",-0.47609,-1.38,0.103,7298,0.666,"NDUFV2, COX7C, NDUFS4, SDHB, NDUFB5, UBE2J2, COX4I1, SLC18A1, SDHC, COX6B1, COX6A1, CYCS, NDUFV1, UQCRC1, COX7A2, NDUFA6, NDUFC1, UBE2G2, UBE2G1, HTRA2, NDUFA7, NDUFA8, NDUFA4, NDUFS5, PARK7, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, SLC25A6, NDUFA2, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, VDAC1, NDUFA3, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, ATP5F1C, ATP5F1B, ATP5PB, SLC25A4, ATP5PD, NDUFB2, ATP5MC2, UCHL1",0.987162775294828,0.176525770829699,FALSE +"proteomics","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.24664,0.687,0.884,646,1,"LY96, CDH1, TUBA4A, CTNNB1",0.0535477349869269,0,FALSE +"proteomics","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.24197,0.671,0.906,2654,0.996,"RAC2, BCL2, CDH1, PTGS2, VEGFA, CTNNA1, LAMC2, LAMB3, RXRA, RXRG, TRAF4, CTNNA2, CTNNB1, TGFA, ERBB2, WNT5B, VEGFC, PIK3CD, RAC3, EP300, MECOM, RARA, RUNX1, ITGA2, LAMA3, LAMA4, NCOA4, EGFR, CKS1B, CDK4, RALB, SKP2, AR, LEF1, CCND1, STAT1, TRAF6, KRAS, NRAS, CDKN1A, ITGA3, WNT11, DVL1, FLT3, MAX, RHOA, MMP2, BCR, CREBBP, PIK3R2, TP53, JAK1, RAC1, PIAS3, HIF1A, MET, SLC2A1, PIK3CA, CTBP1, STAT3, IKBKB, HRAS, MAPK3, LAMB1, WNT5A, NFKBIA, CBLB, GRB2, IGF1R, SOS2, CDKN2A, TCF7L1, HDAC1, PAX8",0.0428718023231869,0.00174066157630127,FALSE +"proteomics","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.39564,1.1,0.317,6667,0.698,"DCXR, UGP2, XYLB, UGDH, CRYL1, UGT2B11, UGT2B4, RPE, GUSB, AKR1B1",0.498940737782249,0.156144577376839,FALSE +"proteomics","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.50211,1.41,0.105,829,0.583,"ALDOB, FBP1, ALDOC, FBP2",0.978810700930062,0.234331445240986,FALSE +"proteomics","Log2FC","KEGG_PEROXISOME",0.32858,0.936,0.506,2901,0.948,"FAR1, PXMP4, EPHX2, PEX13, MVK, ACSL4, ACOT8, ACAA1, AMACR, ACSL1, CAT, CRAT, ACOX1, SLC25A17, FAR2, SCP2, CROT, ACSL6, GSTK1, IDH2, ACOX3, ACSL5, PMVK, PEX7, NUDT12, ACSL3, ABCD3, IDH1, PXMP2",0.295849483160201,0.0231916626619338,FALSE +"proteomics","Log2FC","KEGG_PHENYLALANINE_METABOLISM",-0.44236,-1.3,0.184,10509,0.624,"MAOB, NAA80, ALDH3A1",0.735182176990464,0.204815410317576,FALSE +"proteomics","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.26615,0.746,0.809,2260,1,"IMPA2, DGKA, INPP4B, PIK3CD, PIP4K2C, CDS1, DGKH, DGKB, PIK3R2, PLCB1, PIK3C2B, PIK3CA, PI4KA, PLCD1",0.0920514783877277,0,FALSE +"proteomics","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.41459,-1.23,0.192,8765,0.521,"BLVRA, HMBS, PPOX, EARS2, BLVRB, HMOX1, ALAS1, UROD, UROS, FECH",0.71669877129645,0.283162276700476,FALSE +"proteomics","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.40642,1.15,0.269,1703,0.694,"CD36, PLTP, LPL, FADS2, FABP6, FABP2, RXRA, RXRG, SCD5, ACSL4, FABP3, APOC3, ACAA1, PDPK1, ACSL1, ACOX1, CPT2, SCP2, ACSL6, HMGCS2",0.570247719997592,0.158640529545145,FALSE +"proteomics","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.44792,1.25,0.196,1638,0.608,"CYP7B1, AMACR, SCP2",0.707743928643524,0.216096420727265,FALSE +"proteomics","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.32308,-0.922,0.49,9562,0.707,"RFX5, RFXAP, CD40, BLNK",0.309803919971486,0.150580586203101,FALSE +"proteomics","Log2FC","KEGG_PRION_DISEASES",-0.62081,-1.84,0.0198,10295,0.408,"C7, SOD1, C9, NCAM1, IL1A, NCAM2, EGR1",1.70333480973847,0.38933983691012,FALSE +"proteomics","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.25639,0.729,0.844,3263,1,"FZR1, MAPK12, PIK3CD, MAPK13, ANAPC11, CCNB1, KRAS, BUB1, CCNA2, RPS6KA1, PIK3R2, RPS6KA6, PIK3CA, RPS6KA2, MAPK3, IGF1R, MAPK14, RPS6KA3, MAPK1, GNAI2, GNAI3, CCNB3, ADCY9, PKMYT1",0.073657553374345,0,FALSE +"proteomics","Log2FC","KEGG_PROPANOATE_METABOLISM",-0.26044,-0.763,0.769,10443,0.888,"ALDH2, ALDH7A1, ACSS3",0.114073660198569,0.051587034221399,FALSE +"proteomics","Log2FC","KEGG_PROSTATE_CANCER",0.32384,0.906,0.547,2624,0.982,"BCL2, CTNNB1, TGFA, ERBB2, PIK3CD, EP300, EGFR, AR, LEF1, PDPK1, CCND1, KRAS, NRAS, CDKN1A, CREBBP, PDGFC, PIK3R2, CREB3L2, TP53, CREB3L1, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, GRB2, IGF1R, SOS2, TCF7L1",0.262012673666569,0.00788851221305034,FALSE +"proteomics","Log2FC","KEGG_PROTEASOME",0.2805,0.799,0.719,7310,0.996,"PSMB10, PSMB8, PSME2, PSME1, POMP, PSMB1, PSMB9, PSMA7, PSMA1, PSMA2, PSME3, PSMA8, PSMA3, PSMB2, PSMC6, PSMB3, PSMD7, PSME4, PSMA5, PSMB4, PSMA4, PSMD4, PSMD2, PSMB7, PSMD3, PSMD11, PSMC2, PSMC4, PSMC3, PSMC5, PSMF1, PSMD12, PSMD13, PSMA6, PSMC1, PSMB6, PSMD14, PSMD6, PSMD8, PSMD1, SEM1",0.143271109617117,0.00174066157630127,FALSE +"proteomics","Log2FC","KEGG_PROTEIN_EXPORT",-0.34994,-1.03,0.366,7823,0.626,"SEC61B, IMMP2L, SEC11C, SEC63, IMMP1L, SEC61A2",0.436518914605589,0.20342566678957,FALSE +"proteomics","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.28081,0.789,0.741,3930,1,"ATP1A2, GLUD2, AQP1, SLC38A3, ATP1A3, ATP1A4, ATP1A1, SLC9A3, PCK1, ATP1B1",0.130181792020672,0,FALSE +"proteomics","Log2FC","KEGG_PURINE_METABOLISM",-0.26075,-0.764,0.767,7632,0.902,"PRIM2, PDE4D, POLA1, POLR3C, HPRT1, POLR2E, POLR3A, POLR3H, PDE8A, ENTPD4, GMPR2, POLA2, POLR2H, NUDT9, PNPT1, ATIC, NME2, ADCY3, ADCY8, PAPSS2, AK5, NUDT2, POLR3GL, GDA, POLR1E, GMPS, RRM2B, ADCY10, NPR2, GART, PFAS, NT5C, NME4, NUDT5, PDE3A, ADCY6, ENTPD1, PDE4A, NME1, NPR1, PDE1C, ENTPD8",0.115204636051019,0.0447934624580583,FALSE +"proteomics","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.20888,-0.611,0.973,7564,0.999,"POLR2A, AK3, PRIM2, DHODH, DCTD, POLA1, POLR3C, POLR2E, POLR3A, POLR3H, ENTPD4, POLA2, POLR2H, PNPT1, NME2, DTYMK, NUDT2, TYMS, POLR3GL, POLR1E, CAD, RRM2B, DUT, UCK2, NT5C, UMPS, NME4, TXNRD1, ENTPD1, CTPS1, NME1, ENTPD8",0.0118871597316481,0.000434511774017692,FALSE +"proteomics","Log2FC","KEGG_PYRUVATE_METABOLISM",-0.33889,-1.01,0.38,7380,0.62,"ACYP2, GRHPR, ACACA, PDHB, ALDH9A1, ME2, ALDH1B1, PDHA1, ACAT1, ALDH3A2, GLO1, PCK2, HAGH, ME3, ALDH2, ALDH7A1",0.42021640338319,0.207608310501746,FALSE +"proteomics","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.26341,0.738,0.83,1559,1,"ITGB6, RAC2, ITGAL, PAK5, PAK6, ITGB8, ITGB2, ACTN3, ITGB4, BAIAP2, SCIN, MYH14, PIK3CD, PIP4K2C, SLC9A1, RAC3, VAV1, GSN, ITGA2, ITGA11, EGFR, SSH3, VAV2, FGD3, ITGA4, KRAS, NRAS",0.0809219076239261,0,FALSE +"proteomics","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.43145,-1.22,0.195,7210,0.5,"PIK3R4, ATG4B, ULK1, ATG5, PIK3C3, GABARAPL1, ATG3, ATG7, ULK3, PRKAA2",0.709965388637482,0.301029995663981,FALSE +"proteomics","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.3892,1.1,0.324,2561,0.698,"PAK5, PAK6, VEGFA, TGFA, VEGFC, PIK3CD, EP300, GAB1, KRAS, NRAS, CREBBP, PIK3R2, RAC1, HIF1A, MET, SLC2A1, PIK3CA, HRAS, MAPK3, GRB2, SOS2",0.489454989793388,0.156144577376839,FALSE +"proteomics","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.32703,-0.923,0.523,9197,0.719,"NLN, AGT, CTSG, ACE2",0.281498311132726,0.143271109617117,FALSE +"proteomics","Log2FC","KEGG_RETINOL_METABOLISM",-0.40251,-1.17,0.232,10576,0.565,"ALDH1A2, ALDH1A1, CYP3A7",0.6345120151091,0.247951552180562,FALSE +"proteomics","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",0.46483,1.31,0.151,593,0.557,"ACP5, MTMR7, TYR",0.821023052706831,0.254144804826271,FALSE +"proteomics","Log2FC","KEGG_RIBOSOME",-0.54955,-1.62,0.0466,6763,0.472,"RPSA, RPS16, RPS26, MRPL13, RPL13, RPL11, RPS25, RPL37A, RPL35, RPS4X, RPL27, RPS21, RPS28, RPS27L, RPS15A, RPS2, RPL14, FAU, RPL23, RPL7A, RPL29, RPS29, RPL21, RPL5, RPL34, RPL22, RPS9, RPS3, RPS18, RPL17, RPL15, RPL8, RPL18A, RPS3A, RPS12, RPL28, RPS11, RPL36, RPS17, RPL36A, RPL36AL, RPL3, RPL13A, RPL32, RPL26, RPL27A, RPS8, RPL10A, RPS7, RPS24, RPL7, RPS23, RPL31, RPL9, RPS13, RPL35A, RPL18, RPL19, RPL24, RSL24D1, RPL4, RPS20, RPL6, RPL38, RPS6, RPL37, RPL26L1, RPS4Y1",1.33161408331,0.326058001365912,FALSE +"proteomics","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.21434,0.604,0.954,1713,1,"ISG15, MAPK12, MAPK13, CASP10, DDX58, DHX58, TRAF6, MAP3K1",0.0204516252959049,0,FALSE +"proteomics","Log2FC","KEGG_RNA_DEGRADATION",-0.43669,-1.29,0.158,7190,0.609,"TTC37, EXOSC3, EXOSC2, EXOSC4, DIS3, EXOSC9, EXOSC5, EXOSC7, LSM2, PNPT1, EXOSC10, EXOSC8, LSM1, EXOSC1, MTREX, ENO3, HSPD1, HSPA9, PARN, TENT4A, DCP2, MPHOSPH6, DCPS, DCP1B",0.801342913045577,0.215382707367125,FALSE +"proteomics","Log2FC","KEGG_RNA_POLYMERASE",-0.42301,-1.24,0.195,5911,0.545,"POLR3F, POLR1B, POLR2D, POLR3K, POLR2B, POLR2G, POLR2C, POLR1A, POLR3B, POLR1C, POLR1D, POLR3D, POLR2L, POLR2I, POLR2A, POLR3C, POLR2E, POLR3A, POLR3H, POLR2H, POLR3GL, POLR1E",0.709965388637482,0.263603497723358,FALSE +"proteomics","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",0.26182,0.75,0.809,2085,1,"GGT5, CTH, METTL6, GGT7",0.0920514783877277,0,FALSE +"proteomics","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.31583,0.88,0.593,2488,0.962,"BCL2, PTGS2, LAMC2, LAMB3, RXRA, RXRG, TRAF4, PIK3CD, ITGA2, LAMA3, LAMA4, CKS1B, CDK4, SKP2, CCND1, TRAF6, ITGA3, MAX, PIK3R2, TP53, PIAS3, PIK3CA, IKBKB, LAMB1, NFKBIA",0.226945306635737,0.0168249279621871,FALSE +"proteomics","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.25505,0.718,0.837,3653,1,"VAMP8, VAMP4, TSNARE1, BET1L, STX17, SNAP47, STX3, GOSR1, STX10, SNAP29, STX16, STX18, STX12, STX6, VTI1B, SNAP23",0.07727454200674,0,FALSE +"proteomics","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",0.29469,0.817,0.689,2465,0.994,"CERK, NEU1, UGT8, SGPP2, SPTLC2, GALC, PLPP3, DEGS1, SPTLC1",0.161780778092374,0.00261361560268669,FALSE +"proteomics","Log2FC","KEGG_SPLICEOSOME",-0.44795,-1.27,0.184,6622,0.538,"BCAS2, SNRPD1, SNRPD2, USP39, SF3A2, PRPF6, LSM3, THOC2, SNW1, SRSF6, SYF2, PQBP1, HNRNPA1, U2AF2, ACIN1, SNRPB2, MAGOHB, SRSF7, PRPF40A, HSPA8, HNRNPC, SNRPC, PPIL1, THOC1, RBM25, CTNNBL1, ZMAT2, SNRNP200, PRPF38B, HNRNPK, PRPF31, PPIH, HNRNPM, EIF4A3, DDX46, DDX39B, HNRNPA3, SF3A3, SRSF9, U2AF1, SRSF1, DDX23, SRSF4, SNRPA, SNRNP27, EFTUD2, SRSF8, PRPF38A, TRA2B, SNRPD3, DHX16, PPIE, SNRPF, SRSF3, LSM2, ALYREF, RBM8A, RBM17, SRSF2, SF3B4, TCERG1, RBMX, PRPF8, CDC40, U2SURP, SMNDC1, WBP11, RBM22, SNRNP40, SLU7, PRPF18, TRA2A, BUD31, SNU13, TXNL4A, CHERP, HNRNPU",0.735182176990464,0.269217724333611,FALSE +"proteomics","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.44846,1.24,0.195,2989,0.612,"HK1, SI, PYGB, PGM1, HK2, GAA, PGM2, AGL, PYGL, GYS1, UGP2, MGAM, PGM2L1",0.709965388637482,0.213248577854439,FALSE +"proteomics","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.72045,2.02,0.00637,2290,0.554,"DHCR24, MSMO1, FDFT1, CYP27B1, DHCR7, SC5D, SQLE, NSDHL, HSD17B7, CYP51A1, LSS",2.19586056766465,0.25649023527157,FALSE +"proteomics","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.44063,-1.31,0.15,10468,0.637,"AKR1D1, CYP21A2, AKR1C1, AKR1C3, AKR1C2, CYP3A7",0.823908740944319,0.19586056766465,FALSE +"proteomics","Log2FC","KEGG_SULFUR_METABOLISM",0.57977,1.61,0.0561,1903,0.604,"SULT2B1, SULT1A3, CHST12",1.25103713874384,0.218963061378868,FALSE +"proteomics","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.47545,-1.37,0.141,9770,0.559,"CTSG, C7, CD40, C9, C1S",0.85078088734462,0.252588192113577,FALSE +"proteomics","Log2FC","KEGG_TASTE_TRANSDUCTION",0.39951,1.11,0.291,89,0.706,"SCNN1A",0.536107011014093,0.151195298948196,FALSE +"proteomics","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.5101,1.43,0.0917,2497,0.601,"HMGCS1, MVK, HMGCR, HMGCS2, PDSS2, PMVK, FDPS",1.03763066432998,0.22112552799726,FALSE +"proteomics","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.42677,-1.27,0.174,9929,0.538,"TGFB3, THBS4, THBS3, TGFB1, SMAD2, BMPR2, MYC, INHBA, FST, ACVR2A, TGFB2, BMPR1A, INHBE",0.7594507517174,0.269217724333611,FALSE +"proteomics","Log2FC","KEGG_THYROID_CANCER",0.56509,1.58,0.0367,2845,0.551,"CDH1, RXRA, RXRG, CTNNB1, NCOA4, LEF1, CCND1, KRAS, NRAS, TP53, HRAS, MAPK3, TCF7L1, PAX8, MAPK1",1.43533393574791,0.258848401148215,FALSE +"proteomics","Log2FC","KEGG_TIGHT_JUNCTION",0.5679,1.55,0.0531,1947,0.569,"CLDN18, CLDN4, CLDN7, CRB3, MYH7, PRKCH, EPB41L1, CGN, CLDN3, F11R, CLDN6, TJP3, ACTN3, CTNNA1, PRKCD, JAM2, PATJ, CTNNA2, CTNNB1, MYH14, MYH7B, TJP2, LLGL2, CDK4, MAGI3, PRKCQ, CASK, KRAS, NRAS, PRKCZ, PRKCI, CTTN, PARD6G, YES1, CLDN11, EXOC3, MYL9, RHOA, EXOC4",1.27490547891853,0.244887733604929,FALSE +"proteomics","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.24732,0.693,0.877,2883,1,"LY96, IRF5, MAPK12, PIK3CD, MAPK13, MYD88, STAT1, TRAF6, PIK3R2, RAC1, PIK3CA, IKBKB, MAPK3, NFKBIA, IKBKE, MAPK14, CASP8, MAPK1, IL1B",0.0570004066339595,0,FALSE +"proteomics","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",-0.38666,-1.12,0.269,10040,0.553,"WARS2, ALDH2, MAOB, ALDH7A1, AADAT, KYNU",0.570247719997592,0.257274868695302,FALSE +"proteomics","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",-0.31589,-0.937,0.499,10063,0.704,"MAPK8, GCK, SOCS2, SOCS4",0.30189945437661,0.152427340857888,FALSE +"proteomics","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",0.44767,1.26,0.184,1073,0.604,"CPE, PTPRN2, ICA1",0.735182176990464,0.218963061378868,FALSE +"proteomics","Log2FC","KEGG_TYROSINE_METABOLISM",0.29251,0.817,0.703,2304,0.994,"ADH4, ADH7, TYR, HGD, ALDH1A3, ALDH3B1, METTL6, ADH1C, COMT, TAT, MIF",0.153044674980176,0.00261361560268669,FALSE +"proteomics","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.50774,1.41,0.105,2664,0.583,"PAK5, PAK6, LCK, CARD11, MAPK12, NFATC4, PIK3CD, MAPK13, PTPN6, PPP3R1, VAV1, LCP2, CDK4, PPP3CA, VAV2, PDPK1, PPP3CB, PPP3R2, PRKCQ, KRAS, NRAS, RHOA, NFATC1, PTPRC, PIK3R2, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, CBLB, VAV3, GRB2, NFATC3, NFATC2, SOS2, TEC, MAPK14",0.978810700930062,0.234331445240986,FALSE +"proteomics","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.18021,0.514,0.992,2223,1,"FZR1, UBE2C, UBA7, UBE2E3, ANAPC11, TRIM37, SKP2, RCHY1, MGRN1, UBOX5, UBE2L6, KEAP1, TRAF6, MAP3K1, UBE2O, ITCH, UBA6, PIAS3, BRCA1",0.00348832784582135,0,FALSE +"proteomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.33808,-0.986,0.445,7753,0.654,"PDHB, PDHA1, LARS2, BCAT1",0.351639989019068,0.184422251675733,FALSE +"proteomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.25067,0.702,0.903,2361,1,"ABAT, HMGCS1, ALDH6A1, ACAD8, ACAA1, BCAT2, HMGCS2, MCCC1, HIBADH, ACADM, DBT, ACADS",0.0443122496864942,0,FALSE +"proteomics","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.285,-0.854,0.598,9514,0.777,"NPR2, ITPR1, PLCB2, ARHGEF11, ARHGEF1, PLCB4, PLA2G6, ADCY6, NPR1, CALD1, KCNMA1, PPP1R14A",0.223298816011589,0.109578981199086,FALSE +"proteomics","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.2868,0.808,0.735,2159,0.989,"ARHGDIB, AQP3, DYNLL2, RAB11B, CREB3L2, CREB3L1, RAB11A",0.133712660915805,0.0048037084028206,FALSE +"proteomics","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.53564,1.51,0.0619,2664,0.569,"RAC2, PTGS2, VEGFA, HSPB1, MAPK12, NOS3, NFATC4, PIK3CD, MAPK13, PLA2G12A, RAC3, PPP3R1, PPP3CA, PLA2G2A, PPP3CB, PPP3R2, KRAS, NRAS, NFATC1, PIK3R2, MAPKAPK3, RAC1, PIK3CA, HRAS, MAPK3, NFATC3, NFATC2, MAPK14",1.20830935097988,0.244887733604929,FALSE +"proteomics","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",0.14569,0.405,1,1695,1,"TJP2, ERO1A, PDIA4, KDELR3",0,0,FALSE +"proteomics","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.40292,1.12,0.291,1355,0.698,"RAC2, MYH7, ITGAL, ITGB2, MYH14, MYH7B, RAC3, SGCG, CCND1",0.536107011014093,0.156144577376839,FALSE +"proteomics","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.29792,0.841,0.662,2624,1,"RAC2, VANGL2, SFRP4, CTNNB1, NFATC4, WNT5B, DAAM1, RAC3, EP300, PPP3R1, CSNK1A1, TBL1XR1, PPP3CA, LEF1, CCND1, PPP3CB, PPP2R5E, PPP3R2, LRP5, PPP2R5B, SENP2, DKK1, WNT11, DVL1, RHOA, NFATC1, CREBBP, TP53, PLCB1, RAC1, CHD8, CTBP1, CSNK1E, CAMK2D, WNT5A, NFATC3, NFATC2, TCF7L1",0.1791420105603,0,FALSE +"metabolomics","Log2FC","alpha amino acids",-0.62759,-1.46,0.0709,172,0.169,"sarcosine, phosphocreatine, creatinine, dimethylglycine, citrulline, ornithine, homocysteine",1.14935376481693,0.772113295386326,FALSE +"metabolomics","Log2FC","acyl carnitines",-0.61528,-1.41,0.119,202,0.105,"hexanoylcarnitine, malonylcarnitine, propionylcarnitine",0.924453038607469,0.978810700930062,FALSE diff --git a/Examples/Fig3/GSEA/GSEA_venn_diagram.pdf b/Examples/Fig3/GSEA/GSEA_venn_diagram.pdf new file mode 100644 index 0000000000000000000000000000000000000000..397fb70a87eff7d776b3d08f38c3d28683691da6 GIT binary patch literal 6471 zcmZ`;c|4Tu_g3D>w8);w3`G>ij4>!nmWHD2ku774X^I(U$vXBeyObreM5K}=Axp}h zHCriV-%0kd|DMrX@Amu7=W}@O>zs3+^PKU=bseJmnkXrlGy){*JLo&)+v?k4Ndmzj zG7zHeb&!%02&zHCqA7SHK@&~ELc}#s!)4$I8JLVBOhyiYkdpvGFB0wkr_UHqaR9Om zAzCD~(=|MX4AG-foTwBaO`k-xqhhcmh8H0%D-8p%omxZ&Bmq)U0bvPtj4t56yMaKB z-JGxxs0NyXb|B&)P<=EGONPh-0fvyj66F7rz=&f+lduHJpW#pqB7p)N$q2#A$~ 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+
+ + + + diff --git a/Examples/Fig4/DMEA/DMEA_mean_results.csv b/Examples/Fig4/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..5ba83f4 --- /dev/null +++ b/Examples/Fig4/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"acetylcholine receptor agonist",1.71,0.330454232837166,0.0392238747624452,"transcriptomics, proteomics, metabolomics",3,1,"transcriptomics",0.21703877368553 +"MDM inhibitor",1.62,0.681102048154313,0.188660309188708,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.602261756256262 +"ATPase inhibitor",1.61333333333333,0.39272551907577,0.0112250442412866,"transcriptomics, proteomics, metabolomics",3,1,"proteomics",0.135870453931087 +"sterol demethylase inhibitor",1.59,0.550545184340032,0.00214591881540417,"transcriptomics, proteomics, metabolomics",3,1,"proteomics",0.0593704205595154 +"PLK inhibitor",1.584,0.68851143781349,0.000626169232500466,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, proteomics",0.0346620027944518 +"DNA inhibitor",1.28666666666667,0.0750555349946514,0.125629313988104,"transcriptomics, proteomics, metabolomics",3,0,"",0.489501665952806 +"androgen receptor antagonist",1.21966666666667,0.693870545082679,0.0772833971310988,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.377324821287129 +"CC chemokine receptor antagonist",1.18666666666667,0.361155552820849,0.19603359140473,"transcriptomics, proteomics, metabolomics",3,0,"",0.602621780984912 +"estrogen receptor agonist",1.16533333333333,0.247033061215161,0.246748051769973,"transcriptomics, proteomics, metabolomics",3,0,"",0.640002759278367 +"progesterone receptor agonist",1.05566666666667,0.396706860708677,0.32951191602721,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858 +"antioxidant",0.987,0.170402464770906,0.55992464618085,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842 +"tubulin polymerization inhibitor",0.964,0.28479466287134,0.55518712824729,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842 +"Aurora kinase inhibitor",0.962666666666667,0.376432375511636,0.508295283552775,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842 +"dopamine receptor antagonist",0.957,0.335214856472681,0.550338006771623,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842 +"protein synthesis inhibitor",0.954333333333333,0.161202770861215,0.60457277403347,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117 +"serotonin receptor agonist",0.757,1.32189523034165,0.0914955488402172,"transcriptomics, proteomics, metabolomics",3,0,"",0.399691081775686 +"bacterial 50S ribosomal subunit inhibitor",0.701333333333333,1.41005862762274,0.0460458802029331,"transcriptomics, proteomics, metabolomics",3,0,"",0.238863003552715 +"glucocorticoid receptor agonist",0.638,1.10047444313805,0.389753605653181,"transcriptomics, proteomics, metabolomics",3,0,"",0.718878872649201 +"DNA polymerase inhibitor",0.544333333333333,1.06111560790205,0.520318935072838,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842 +"mTOR inhibitor",0.489666666666667,0.989110880201676,0.645230401470049,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117 +"bacterial DNA gyrase inhibitor",0.489,0.972143507924627,0.646573085186216,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117 +"HMGCR inhibitor",0.483333333333333,1.41736845362571,0.135645039962826,"transcriptomics, proteomics, metabolomics",3,0,"",0.489501665952806 +"HCV inhibitor",0.436666666666667,1.7931629410997,0.015096842163348,"transcriptomics, proteomics, metabolomics",3,0,"",0.135870453931087 +"growth factor receptor inhibitor",0.426666666666667,1.49901078492896,0.135292699781582,"transcriptomics, proteomics, metabolomics",3,0,"",0.489501665952806 +"ribonucleotide reductase inhibitor",0.412666666666667,1.23362933384925,0.376560550554142,"transcriptomics, proteomics, metabolomics",3,0,"",0.710330129454404 +"serotonin receptor antagonist",0.393,1.09220373557318,0.627988593244907,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117 +"JAK inhibitor",0.370333333333333,1.14195461089018,0.547577538955838,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842 +"PI3K inhibitor",0.370333333333333,0.728522706120635,0.959364387548974,"transcriptomics, proteomics, metabolomics",3,0,"",0.99320518653544 +"FLT3 inhibitor",0.34,1.01956068970905,0.72737145097148,"transcriptomics, proteomics, metabolomics",3,0,"",0.850307470853983 +"estrogen receptor antagonist",0.334666666666667,1.12383821492835,0.582820721885315,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117 +"adrenergic receptor antagonist",0.33,0.806980173238475,0.930447000027383,"transcriptomics, proteomics, metabolomics",3,0,"",0.990091038490677 +"FGFR inhibitor",0.327333333333333,1.19305546113051,0.475668442774605,"transcriptomics, proteomics, metabolomics",3,0,"",0.774127073535142 +"topoisomerase inhibitor",0.191666666666667,1.43556899288517,0.219867894895788,"transcriptomics, proteomics, metabolomics",3,0,"",0.608301175878347 +"BCL inhibitor",0.172666666666667,1.1109677463065,0.696863742644651,"transcriptomics, proteomics, metabolomics",3,0,"",0.838256386079797 +"microtubule inhibitor",0.170666666666667,0.764280271453695,0.990984682883397,"transcriptomics, proteomics, metabolomics",3,0,"",0.998303322165083 +"bromodomain inhibitor",0.156666666666667,1.24599250934078,0.505326341211283,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842 +"opioid receptor agonist",0.098,1.50011732874466,0.125001127585286,"transcriptomics, proteomics, metabolomics",3,1,"transcriptomics",0.489501665952806 +"phosphatase inhibitor",0.0383333333333333,1.19612053461737,0.593922201329678,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117 +"benzodiazepine receptor agonist",-0.127,1.27227630646806,0.451413327845409,"transcriptomics, proteomics, metabolomics",3,0,"",0.749346124223379 +"PARP inhibitor",-0.135666666666667,1.33507165850127,0.347580011944954,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858 +"DNA synthesis inhibitor",-0.141333333333333,0.823812074039543,0.967222472332557,"transcriptomics, proteomics, metabolomics",3,0,"",0.99320518653544 +"PDGFR tyrosine kinase receptor inhibitor",-0.147,1.31258409254417,0.370423346343372,"transcriptomics, proteomics, metabolomics",3,0,"",0.710330129454404 +"calcium channel blocker",-0.151333333333333,0.696685246961161,0.998303322165083,"transcriptomics, proteomics, metabolomics",3,0,"",0.998303322165083 +"Abl kinase inhibitor",-0.159666666666667,1.27335082885014,0.412677026819624,"transcriptomics, proteomics, metabolomics",3,0,"",0.728508511492598 +"tyrosine kinase inhibitor",-0.245,0.993844555249965,0.826821084410066,"transcriptomics, proteomics, metabolomics",3,0,"",0.915146790059076 +"CDK inhibitor",-0.249,1.08681323142479,0.626826576582264,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117 +"VEGFR inhibitor",-0.259,1.26753027577254,0.430083338110088,"transcriptomics, proteomics, metabolomics",3,0,"",0.728508511492598 +"p38 MAPK inhibitor",-0.276666666666667,1.34886371933318,0.337110066408449,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858 +"potassium channel blocker",-0.277666666666667,1.11229777188185,0.637553812478839,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117 +"protein tyrosine kinase inhibitor",-0.284,1.01960629656745,0.784618613149266,"transcriptomics, proteomics, metabolomics",3,0,"",0.904490901269293 +"KIT inhibitor",-0.303666666666667,1.33006403354626,0.302639275105415,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858 +"retinoid receptor agonist",-0.314333333333333,0.918232178336903,0.879548811247694,"transcriptomics, proteomics, metabolomics",3,0,"",0.948085082254007 +"NFkB pathway inhibitor",-0.317666666666667,0.767009995588932,0.9692725314382,"transcriptomics, proteomics, metabolomics",3,0,"",0.99320518653544 +"PPAR receptor agonist",-0.336,1.45878990947977,0.175662896954226,"transcriptomics, proteomics, metabolomics",3,0,"",0.583200817888031 +"DNA alkylating agent",-0.336333333333333,0.940261842963615,0.82693987053531,"transcriptomics, proteomics, metabolomics",3,0,"",0.915146790059076 +"thymidylate synthase inhibitor",-0.346666666666667,1.47571451620337,0.153259941840201,"transcriptomics, proteomics, metabolomics",3,0,"",0.530023965530695 +"cyclooxygenase inhibitor",-0.392666666666667,0.890733592794913,0.859987268405275,"transcriptomics, proteomics, metabolomics",3,0,"",0.939196622074182 +"AP inhibitor",-0.406666666666667,1.01398685067082,0.715613413756915,"transcriptomics, proteomics, metabolomics",3,0,"",0.848513047740342 +"HSP inhibitor",-0.464,1.0904292732681,0.559753358803866,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842 +"sodium channel blocker",-0.485666666666667,0.855131763726113,0.80245922597919,"transcriptomics, proteomics, metabolomics",3,0,"",0.912385147346203 +"RET tyrosine kinase inhibitor",-0.51,1.7516849031718,0.0180069276294212,"transcriptomics, proteomics, metabolomics",3,0,"",0.135870453931087 +"TGF beta receptor inhibitor",-0.524,1.11774907738723,0.424146685687652,"transcriptomics, proteomics, metabolomics",3,0,"",0.728508511492598 +"histamine receptor antagonist",-0.526666666666667,1.24460167657501,0.283848312021223,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858 +"glutamate receptor antagonist",-0.557,1.21129558737742,0.30051864145804,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858 +"DNA methyltransferase inhibitor",-0.576666666666667,1.64591413303773,0.0231385942075001,"transcriptomics, proteomics, metabolomics",3,0,"",0.137478890683736 +"Bcr.Abl kinase inhibitor",-0.599333333333333,1.18000056497162,0.244003437916364,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.640002759278367 +"AKT inhibitor",-0.668,1.15388560958182,0.20628917647822,"transcriptomics, proteomics, metabolomics",3,0,"",0.608301175878347 +"RAF inhibitor",-0.73,1.57101877773628,0.0231892104767748,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.137478890683736 +"adenosine receptor antagonist",-0.878333333333333,1.45108867176797,0.013547386796645,"transcriptomics, proteomics, metabolomics",3,0,"",0.135870453931087 +"MEK inhibitor",-0.9,0.491939020611295,0.537094488964896,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842 +"glycogen synthase kinase inhibitor",-1.01466666666667,0.40656774753211,0.344080244798991,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858 +"ALK tyrosine kinase receptor inhibitor",-1.037,0.280957292128181,0.41251678411073,"transcriptomics, proteomics, metabolomics",3,0,"",0.728508511492598 +"adrenergic receptor agonist",-1.06933333333333,0.277752287719351,0.358414507958658,"transcriptomics, proteomics, metabolomics",3,0,"",0.708295337156395 +"src inhibitor",-1.073,0.387113678394345,0.330624333722932,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858 +"acetylcholine receptor antagonist",-1.07966666666667,0.608601949827088,0.215506210639317,"transcriptomics, proteomics, metabolomics",3,1,"transcriptomics",0.608301175878347 +"cytochrome P450 inhibitor",-1.13,0.0556776436283002,0.340321314694418,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858 +"vitamin D receptor agonist",-1.31,0.3278719262151,0.0883367361148128,"transcriptomics, proteomics, metabolomics",3,0,"",0.399691081775686 +"proteasome inhibitor",-1.43633333333333,0.484758015233718,0.0134619947838327,"transcriptomics, proteomics, metabolomics",3,0,"",0.135870453931087 +"EGFR inhibitor",-1.46666666666667,0.363501490139082,0.0156625955600064,"transcriptomics, proteomics, metabolomics",3,0,"",0.135870453931087 +"phosphodiesterase inhibitor",-1.47333333333333,0.183393929379719,0.0218373546944777,"transcriptomics, proteomics, metabolomics",3,0,"",0.137478890683736 +"MET inhibitor",-1.47933333333333,0.575257623446516,0.00389349804195459,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.0807900843705577 +"HDAC inhibitor",-1.52,0.02,0.0179960517891872,"transcriptomics, proteomics, metabolomics",3,0,"",0.135870453931087 +"CHK inhibitor",-1.76333333333333,0.100166528008778,0.000835228982998839,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.0346620027944518 diff --git a/Examples/Fig4/DMEA/DMEA_results.csv b/Examples/Fig4/DMEA/DMEA_results.csv new file mode 100644 index 0000000..1118bfe --- /dev/null +++ b/Examples/Fig4/DMEA/DMEA_results.csv @@ -0,0 +1,250 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"transcriptomics","Pearson.est","EGFR inhibitor",-0.60353,-1.58,0.0575,1249,0.328,"BMS.690514, GW.583340, OSI.420, XL.647, TAK.285, BIBU.1361, ARRY.334543, tyrphostin.AG.1478, BIBX.1382, PD.153035, PD.168393, dacomitinib, osimertinib, poziotinib, AZD8931, icotinib, pelitinib, afatinib, erlotinib, WZ8040, canertinib, gefitinib",1.24033215531037,0.484126156288321,FALSE +"transcriptomics","Pearson.est","Abl kinase inhibitor",0.22073,0.572,0.941,480,0.962,"GZD824, KW.2449, ponatinib, nilotinib, flumatinib",0.0264103765727431,0.0168249279621871,FALSE +"transcriptomics","Pearson.est","acetylcholine receptor agonist",0.80534,2.09,0,184,0.0587,"oxiracetam, xanomeline, tremorine, pilocarpine",Inf,1.23136189875239,TRUE +"transcriptomics","Pearson.est","acetylcholine receptor antagonist",-0.6719,-1.76,0.0291,1029,0.247,"iododexetimide, darifenacin, diphemanil, dicycloverine",1.53610701101409,0.607303046740334,TRUE +"transcriptomics","Pearson.est","adenosine receptor antagonist",-0.70183,-1.79,0.0123,1430,0.307,"MRS.1220, CGS.15943",1.9100948885606,0.512861624522813,FALSE +"transcriptomics","Pearson.est","adrenergic receptor agonist",-0.53959,-1.38,0.122,1245,0.502,"methyldopa, xylazine, isoetharine, A61603",0.913640169325252,0.299296282854981,FALSE +"transcriptomics","Pearson.est","adrenergic receptor antagonist",-0.21824,-0.579,0.929,1134,0.999,"prazosin, atenolol...., metoprolol, pindolol, RS.17053",0.0319842860063582,0.000434511774017692,FALSE +"transcriptomics","Pearson.est","AKT inhibitor",-0.39785,-1.04,0.397,956,0.768,"MK.2206, palomid.529, GDC.0068, AZD5363, CCT128930, triciribine, A.674563, GSK2110183",0.401209493236885,0.114638779968488,FALSE +"transcriptomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41958,-1.07,0.368,1152,0.751,"CEP.37440, GW.788388, NVP.TAE684, AP26113, lorlatinib",0.434152181326482,0.124360062995832,FALSE +"transcriptomics","Pearson.est","androgen receptor antagonist",0.32807,0.852,0.624,105,0.774,"RU.58841",0.204815410317576,0.111259039317107,FALSE +"transcriptomics","Pearson.est","antioxidant",0.41749,1.07,0.376,212,0.632,"mesna, trolox",0.424812155072339,0.199282921717615,FALSE +"transcriptomics","Pearson.est","AP inhibitor",0.29867,0.764,0.734,118,0.816,"idronoxil",0.134303940083929,0.0883098412461389,FALSE +"transcriptomics","Pearson.est","ATPase inhibitor",0.49093,1.25,0.225,432,0.64,"oligomycin.a, digoxin, ouabain, evodiamine, digitoxin, digitoxigenin, NMS.873",0.647817481888638,0.193820026016113,FALSE +"transcriptomics","Pearson.est","Aurora kinase inhibitor",0.44967,1.18,0.275,356,0.586,"ENMD.2076, PHA.680632, CCT137690, MK.5108, KW.2449, GSK1070916, AMG900, danusertib, PF.03814735, barasertib",0.560667306169737,0.232102383981909,FALSE +"transcriptomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.6667,1.73,0.0152,177,0.316,"valnemulin, radezolid, azalomycin.b",1.81815641205523,0.500312917381596,FALSE +"transcriptomics","Pearson.est","bacterial DNA gyrase inhibitor",0.40743,1.02,0.411,365,0.613,"nadifloxacin, novobiocin, norfloxacin, finafloxacin",0.386158178123931,0.212539525481585,FALSE +"transcriptomics","Pearson.est","BCL inhibitor",0.32788,0.832,0.655,193,0.787,"venetoclax, TW.37",0.183758700008217,0.104025267640935,FALSE +"transcriptomics","Pearson.est","Bcr.Abl kinase inhibitor",-0.22882,-0.598,0.907,1204,1,"bosutinib, bafetinib",0.0423927129399047,0,FALSE +"transcriptomics","Pearson.est","benzodiazepine receptor agonist",-0.22866,-0.581,0.929,1051,1,"bentazepam, temazepam, indiplon, lorazepam, gamma.aminobutyric.acid",0.0319842860063582,0,FALSE +"transcriptomics","Pearson.est","bromodomain inhibitor",0.30663,0.808,0.66,317,0.786,"I.BET.762, PFI.1",0.180456064458131,0.104577453960592,FALSE +"transcriptomics","Pearson.est","calcium channel blocker",-0.24659,-0.622,0.91,1131,1,"SKF.96365, mibefradil, tetrandrine",0.0409586076789064,0,FALSE +"transcriptomics","Pearson.est","CC chemokine receptor antagonist",0.54314,1.41,0.139,388,0.889,"ZK811752, UNBS.5162, SB.225002, RS.504393",0.856985199745905,0.0510982390297863,FALSE +"transcriptomics","Pearson.est","CDK inhibitor",0.36249,0.925,0.514,226,0.711,"PHA.848125, BMS.265246, R547, ribociclib, AZD5438, indisulam, PHA.793887",0.289036881004724,0.148130399270234,FALSE +"transcriptomics","Pearson.est","CHK inhibitor",-0.69563,-1.8,0.0193,1054,0.575,"LY2603618, AZD7762, SCH.900776, CHIR.124, LY2606368",1.71444269099223,0.24033215531037,FALSE +"transcriptomics","Pearson.est","cyclooxygenase inhibitor",-0.36026,-0.943,0.499,1272,0.832,"tryptanthrin, phenylbutazone, FR.122047, pterostilbene, FK.3311, naproxen",0.30189945437661,0.0798766737092761,FALSE +"transcriptomics","Pearson.est","cytochrome P450 inhibitor",-0.44822,-1.14,0.318,1220,0.823,"morin, itraconazole",0.497572880015567,0.0846001647877302,FALSE +"transcriptomics","Pearson.est","DNA alkylating agent",0.29284,0.742,0.749,268,0.828,"carboplatin, carmustine, temozolomide, cyclophosphamide, mitomycin.c",0.125518182300534,0.0819696632151199,FALSE +"transcriptomics","Pearson.est","DNA inhibitor",0.52484,1.33,0.162,355,0.641,"valrubicin, carboplatin, carmustine, teroxirone, tirapazamine, bendamustine, mechlorethamine, oxaliplatin, nimorazole, pibenzimol",0.790484985457369,0.193141970481183,FALSE +"transcriptomics","Pearson.est","DNA methyltransferase inhibitor",0.51627,1.32,0.174,126,0.574,"decitabine, disulfiram",0.7594507517174,0.241088107602027,FALSE +"transcriptomics","Pearson.est","DNA polymerase inhibitor",0.48256,1.24,0.227,158,0.623,"trifluridine, idoxuridine, foscarnet",0.643974142806877,0.20551195334083,FALSE +"transcriptomics","Pearson.est","DNA synthesis inhibitor",-0.30022,-0.771,0.717,1418,1,"altretamine, estramustine.phosphate",0.1444808443322,0,FALSE +"transcriptomics","Pearson.est","dopamine receptor antagonist",0.32081,0.814,0.658,127,0.796,"thioproperazine, paliperidone, raclopride",0.181774106386044,0.0990869322623309,FALSE +"transcriptomics","Pearson.est","estrogen receptor agonist",0.45859,1.17,0.286,241,0.58,"ethinyl.estradiol, estrone, levonorgestrel",0.543633966870957,0.236572006437063,FALSE +"transcriptomics","Pearson.est","estrogen receptor antagonist",-0.37156,-0.959,0.494,1321,0.843,"fulvestrant",0.306273051076353,0.0741724253752577,FALSE +"transcriptomics","Pearson.est","FGFR inhibitor",0.48692,1.21,0.241,107,0.616,"dovitinib, regorafenib, nintedanib",0.617982957425132,0.210419287835575,FALSE +"transcriptomics","Pearson.est","FLT3 inhibitor",0.43671,1.14,0.288,57,0.607,"sorafenib, dovitinib, TG.101348, ENMD.2076",0.540607512240769,0.216811308924742,FALSE +"transcriptomics","Pearson.est","glucocorticoid receptor agonist",-0.21996,-0.562,0.958,313,0.98,"triamcinolone, fluticasone.propionate, prednisolone, desonide, prednisolone.hemisuccinate, halobetasol.propionate, ciclesonide, rimexolone, beclomethasone.dipropionate, fludroxycortide, methylprednisolone, dexamethasone.acetate, difluprednate, hydrocortisone, prednisolone.acetate, halcinonide, fluocinolone.acetonide, betamethasone, fluorometholone, piretanide, deflazacort, clobetasol.propionate, flumethasone, flumethasone.pivalate, triamcinolone.acetonide",0.0186344909214556,0.00877392430750515,FALSE +"transcriptomics","Pearson.est","glutamate receptor antagonist",-0.45688,-1.18,0.242,1100,0.795,"CPP, LY456236, SIB.1757, JNJ.16259685, kynurenic.acid",0.616184634019569,0.0996328713435297,FALSE +"transcriptomics","Pearson.est","glycogen synthase kinase inhibitor",-0.27288,-0.688,0.829,1019,1,"AZD2858, LY2090314, indirubin, GSK.3.inhibitor.IX",0.0814454694497265,0,FALSE +"transcriptomics","Pearson.est","growth factor receptor inhibitor",0.39619,1.03,0.419,29,0.617,"PHA.848125",0.377785977033705,0.209714835966758,FALSE +"transcriptomics","Pearson.est","HCV inhibitor",0.51968,1.36,0.151,155,0.748,"narlaprevir, mericitabine",0.821023052706831,0.126098402135539,FALSE +"transcriptomics","Pearson.est","HDAC inhibitor",-0.57884,-1.52,0.084,948,0.323,"RG2833, belinostat, pyroxamide, dacinostat, scriptaid, entinostat, R306465, PCI.24781, romidepsin, M.344, panobinostat, SB.939, JNJ.26481585, tacedinaline, nexturastat.a, mocetinostat",1.07572071393812,0.490797477668897,FALSE +"transcriptomics","Pearson.est","histamine receptor antagonist",-0.42199,-1.09,0.345,1359,0.756,"lafutidine, famotidine, chloropyramine",0.462180904926726,0.121478204498793,FALSE +"transcriptomics","Pearson.est","HMGCR inhibitor",0.54206,1.39,0.111,417,0.751,"fluvastatin, atorvastatin, pitavastatin, mevastatin, lovastatin",0.954677021213343,0.124360062995832,FALSE +"transcriptomics","Pearson.est","HSP inhibitor",0.30096,0.786,0.719,358,0.802,"SNX.2112, PU.H71, NVP.AUY922, BIIB021, ganetespib, XL888",0.143271109617117,0.0958256317158365,FALSE +"transcriptomics","Pearson.est","JAK inhibitor",0.47121,1.21,0.244,124,0.616,"AZD1480, TG.101348, baricitinib, AZ960, WHI.P154",0.612610173661271,0.210419287835575,FALSE +"transcriptomics","Pearson.est","KIT inhibitor",0.46077,1.19,0.261,83,0.622,"sorafenib, OSI.930, regorafenib, masitinib",0.583359492661719,0.206209615309181,FALSE +"transcriptomics","Pearson.est","MDM inhibitor",0.3999,1.04,0.396,100,0.641,"idasanutlin, nutlin.3",0.402304814074488,0.193141970481183,FALSE +"transcriptomics","Pearson.est","MEK inhibitor",-0.20098,-0.502,0.978,1443,0.98,"BIX.02188",0.00966114521239857,0.00877392430750515,FALSE +"transcriptomics","Pearson.est","MET inhibitor",-0.32987,-0.868,0.585,1382,0.898,"INC.280",0.23284413391782,0.0467236633326956,FALSE +"transcriptomics","Pearson.est","microtubule inhibitor",-0.27591,-0.711,0.813,1434,1,"estramustine.phosphate",0.0899094544059319,0,FALSE +"transcriptomics","Pearson.est","mTOR inhibitor",0.41613,1.11,0.326,295,0.611,"ku.0063794, AZD2014, voxtalisib, MLN0128, torin.1, XL388, NVP.BEZ235, AZD8055, WYE.354, everolimus",0.486782399932061,0.213958789757446,FALSE +"transcriptomics","Pearson.est","NFkB pathway inhibitor",0.22458,0.568,0.941,151,0.945,"EVP4593, betulinic.acid",0.0264103765727431,0.0245681914907371,FALSE +"transcriptomics","Pearson.est","opioid receptor agonist",0.71254,1.83,0.0124,130,0.221,"trimebutine, salvinorin.a",1.90657831483776,0.655607726314889,TRUE +"transcriptomics","Pearson.est","p38 MAPK inhibitor",-0.41839,-1.1,0.348,1183,0.79,"CMPD.1, SB.239063, TAK.715",0.458420756053419,0.102372908709559,FALSE +"transcriptomics","Pearson.est","PARP inhibitor",0.5393,1.39,0.126,245,0.751,"olaparib, niraparib, talazoparib",0.899629454882437,0.124360062995832,FALSE +"transcriptomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.51602,1.33,0.166,337,0.641,"sorafenib, dovitinib, linifanib, regorafenib, masitinib, nintedanib, crenolanib, axitinib, CP.673451, pazopanib, tandutinib, lenvatinib",0.779891911959945,0.193141970481183,FALSE +"transcriptomics","Pearson.est","phosphatase inhibitor",-0.51711,-1.34,0.168,1395,0.517,"mycophenolate.mofetil, BVT.948",0.774690718274137,0.286509456906058,FALSE +"transcriptomics","Pearson.est","phosphodiesterase inhibitor",-0.65792,-1.68,0.0316,1298,0.3,"cilostamide, zardaverine, enoximone, GSK256066",1.5003129173816,0.522878745280338,FALSE +"transcriptomics","Pearson.est","PI3K inhibitor",0.28333,0.719,0.785,503,0.842,"GDC.0941, voxtalisib, ZSTK.474, NVP.BEZ235, taselisib, PI3K.IN.2, PF.04691502, LY303511, CH5132799, TG.100713, GSK2126458, PIK.75, GDC.0980, alpelisib",0.105130343254747,0.0746879085003505,FALSE +"transcriptomics","Pearson.est","PLK inhibitor",0.74254,1.92,0.00403,378,0.16,"NMS.1286937, volasertib, GW.843682X, BI.2536, rigosertib, GSK461364, HMN.214",2.39469495385889,0.795880017344075,TRUE +"transcriptomics","Pearson.est","potassium channel blocker",0.39764,1,0.429,16,0.625,"ML133",0.367542707815276,0.204119982655925,FALSE +"transcriptomics","Pearson.est","PPAR receptor agonist",-0.59385,-1.53,0.0807,1077,0.353,"clofibrate, oleoylethanolamide, S26948, pterostilbene, GW.501516",1.09312646527793,0.452225294612177,FALSE +"transcriptomics","Pearson.est","progesterone receptor agonist",0.23746,0.607,0.927,415,0.952,"nomegestrol.acetate, levonorgestrel, tanaproget, danazol",0.0329202658555029,0.0213630516155257,FALSE +"transcriptomics","Pearson.est","proteasome inhibitor",-0.34308,-0.879,0.596,940,0.918,"carfilzomib, ONX.0914, oprozomib, ixazomib.citrate",0.224753740259764,0.0371573187987575,FALSE +"transcriptomics","Pearson.est","protein synthesis inhibitor",0.43749,1.12,0.313,244,0.618,"anguidine, harringtonine, cycloheximide, mercaptopurine, bruceantin, thiostrepton",0.504455662453552,0.209011524911184,FALSE +"transcriptomics","Pearson.est","protein tyrosine kinase inhibitor",0.34577,0.888,0.583,19,0.734,"mubritinib",0.234331445240986,0.134303940083929,FALSE +"transcriptomics","Pearson.est","RAF inhibitor",0.40235,1.06,0.365,220,0.627,"sorafenib, regorafenib, dabrafenib, SB.590885",0.437707135543525,0.202732459169284,FALSE +"transcriptomics","Pearson.est","RET tyrosine kinase inhibitor",0.59221,1.51,0.0781,77,0.69,"sorafenib, regorafenib",1.1073489661227,0.161150909262745,FALSE +"transcriptomics","Pearson.est","retinoid receptor agonist",-0.26942,-0.714,0.824,1401,1,"CD.437",0.0840727883028842,0,FALSE +"transcriptomics","Pearson.est","ribonucleotide reductase inhibitor",0.51093,1.32,0.171,538,0.574,"cladribine, fludarabine.phosphate, cytarabine, triapine, pentostatin",0.767003889607846,0.241088107602027,FALSE +"transcriptomics","Pearson.est","serotonin receptor agonist",0.60408,1.55,0.0675,504,0.686,"zolmitriptan, SR.57227A, aripiprazole, pardoprunox, NAN.190",1.17069622716898,0.163675884293248,FALSE +"transcriptomics","Pearson.est","serotonin receptor antagonist",0.40856,1.07,0.39,74,0.632,"SB.200646, SB.216641, paliperidone",0.408935392973501,0.199282921717615,FALSE +"transcriptomics","Pearson.est","sodium channel blocker",-0.44082,-1.11,0.341,1302,0.828,"lappaconite, benzethonium, cibenzoline",0.467245621007502,0.0819696632151199,FALSE +"transcriptomics","Pearson.est","src inhibitor",-0.37709,-0.974,0.461,1204,0.858,"bosutinib, saracatinib, PP.2, PP.1",0.336299074610352,0.0665127121512946,FALSE +"transcriptomics","Pearson.est","sterol demethylase inhibitor",0.3835,0.98,0.471,397,0.639,"lanoconazole, sulconazole, chlormidazole, ketoconazole",0.326979092871104,0.1944991418416,FALSE +"transcriptomics","Pearson.est","TGF beta receptor inhibitor",-0.22757,-0.585,0.925,909,1,"SB.525334, D.4476, repsox, LY2109761",0.0338582672609674,0,FALSE +"transcriptomics","Pearson.est","thymidylate synthase inhibitor",0.51877,1.34,0.167,131,0.732,"trifluridine, carmofur",0.777283528852417,0.135488918941608,FALSE +"transcriptomics","Pearson.est","topoisomerase inhibitor",0.50833,1.3,0.179,232,0.578,"idarubicin, valrubicin, mitoxantrone, etoposide.phosphate, TAS.103, amonafide, amsacrine, voreloxin, topotecan, dexrazoxane, nemorubicin",0.747146969020107,0.238072161579471,FALSE +"transcriptomics","Pearson.est","tubulin polymerization inhibitor",0.40708,1.03,0.404,359,0.617,"verubulin, docetaxel, KX2.391, epothilone.b, mebendazole, vinblastine, taltobulin, vindesine, fosbretabulin, flubendazole",0.393618634889395,0.209714835966758,FALSE +"transcriptomics","Pearson.est","tyrosine kinase inhibitor",0.34788,0.897,0.555,129,0.737,"mubritinib, sorafenib, regorafenib, hypericin",0.255707016877324,0.132532512140949,FALSE +"transcriptomics","Pearson.est","VEGFR inhibitor",0.45481,1.18,0.274,171,0.586,"sorafenib, tivozanib, dovitinib, linifanib, OSI.930, ENMD.2076, regorafenib, nintedanib, golvatinib, axitinib, foretinib",0.562249437179612,0.232102383981909,FALSE +"transcriptomics","Pearson.est","vitamin D receptor agonist",-0.65049,-1.66,0.0426,1277,0.272,"maxacalcitol, calcitriol, paricalcitol",1.37059040089728,0.565431095965801,FALSE +"proteomics","Pearson.est","EGFR inhibitor",-0.67568,-1.76,0.018,1140,0.384,"tucatinib, GW.583340, lapatinib, neratinib, XL.647, tyrphostin.AG.1478, CP.724714, BIBX.1382, poziotinib, TAK.285, AEE788, rociletinib, PD.153035, ARRY.334543, AZD8931, BMS.690514, OSI.420, vandetanib, BIBU.1361, dacomitinib, icotinib, gefitinib, erlotinib, canertinib, PD.168393, osimertinib, afatinib, WZ8040, pelitinib",1.74472749489669,0.415668775632469,FALSE +"proteomics","Pearson.est","Abl kinase inhibitor",0.21727,0.579,0.938,1136,0.938,"GZD824, ponatinib, dasatinib, KW.2449, bafetinib, tozasertib, flumatinib, nilotinib, ZM.306416, bosutinib, imatinib, metatinib",0.0277971616209356,0.0277971616209356,FALSE +"proteomics","Pearson.est","acetylcholine receptor agonist",0.53728,1.49,0.0769,286,0.618,"xanomeline, nicotine, pilocarpine",1.11407366019857,0.209011524911184,FALSE +"proteomics","Pearson.est","acetylcholine receptor antagonist",-0.35846,-0.892,0.577,1371,1,"dicycloverine",0.238824186844269,0,FALSE +"proteomics","Pearson.est","adenosine receptor antagonist",-0.64883,-1.64,0.0386,1336,0.447,"MRS.1220, CGS.15943",1.41341269532825,0.349692476868064,FALSE +"proteomics","Pearson.est","adrenergic receptor agonist",-0.32897,-0.845,0.64,749,1,"norepinephrine, xylazine, midodrine, metaraminol, epinephrine, clenbuterol, methyldopa, terbutaline, isoetharine, isoxsuprine, oxymetazoline, A61603",0.193820026016113,0,FALSE +"proteomics","Pearson.est","adrenergic receptor antagonist",0.23079,0.607,0.893,186,0.976,"dihydroergocristine, naftidrofuryl, atipamezole, metoprolol, idazoxan",0.0491485411114536,0.0105501823333082,FALSE +"proteomics","Pearson.est","AKT inhibitor",-0.61633,-1.59,0.0405,1044,0.346,"ONC201, GSK2110183, uprosertib, triciribine, AZD5363, CCT128930, palomid.529",1.39254497678533,0.460923901207223,FALSE +"proteomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.29684,-0.741,0.763,824,0.878,"SB.505124, AZD3463, CEP.37440, GW.788388, NVP.TAE684, AP26113",0.11747546204512,0.0565054840938974,FALSE +"proteomics","Pearson.est","androgen receptor antagonist",0.29057,0.787,0.686,1029,1,"RU.58841, enzalutamide, nilutamide, bicalutamide, flutamide, cyproterone.acetate",0.163675884293248,0,FALSE +"proteomics","Pearson.est","antioxidant",0.41032,1.1,0.325,223,0.888,"trolox, mesna",0.488116639021126,0.051587034221399,FALSE +"proteomics","Pearson.est","AP inhibitor",-0.39563,-1.01,0.466,864,0.878,"birinapant, LCL.161, tanshinone.i, embelin",0.33161408331,0.0565054840938974,FALSE +"proteomics","Pearson.est","ATPase inhibitor",0.75913,2.03,0.0126,164,0.0599,"k.strophanthidin, oligomycin.a, digoxin, NMS.873, rabeprazole, digitoxigenin, evodiamine",1.89962945488244,1.22257317761069,TRUE +"proteomics","Pearson.est","Aurora kinase inhibitor",0.43678,1.18,0.266,379,0.775,"ENMD.2076, MK.5108, PHA.680632, danusertib, AT.9283, barasertib, AMG900, CCT137690, GSK1070916, barasertib.HQPA, CYC116",0.575118363368933,0.11069829749369,FALSE +"proteomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.48546,1.28,0.195,167,0.696,"radezolid, josamycin",0.709965388637482,0.157390760389438,FALSE +"proteomics","Pearson.est","bacterial DNA gyrase inhibitor",-0.25033,-0.633,0.869,1209,0.949,"trovafloxacin, sparfloxacin",0.0609802235513335,0.0227337875727074,FALSE +"proteomics","Pearson.est","BCL inhibitor",0.29931,0.796,0.709,1017,1,"venetoclax, gossypol, TW.37, ABT.737, obatoclax, navitoclax, HA14.1, oridonin",0.149353764816933,0,FALSE +"proteomics","Pearson.est","Bcr.Abl kinase inhibitor",0.21697,0.58,0.934,1136,0.967,"GZD824, ponatinib, dasatinib, bafetinib, tozasertib, flumatinib, nilotinib, bosutinib, imatinib, metatinib",0.0296531237699066,0.0145735259169983,FALSE +"proteomics","Pearson.est","benzodiazepine receptor agonist",-0.43936,-1.11,0.335,1117,0.76,"lorazepam, indiplon, zaleplon, temazepam, CGS.20625",0.474955192963155,0.119186407719209,FALSE +"proteomics","Pearson.est","bromodomain inhibitor",-0.50519,-1.28,0.203,967,0.568,"I.BET.762, JQ1...., I.BET151, bromosporine",0.692503962086787,0.245651664288981,FALSE +"proteomics","Pearson.est","calcium channel blocker",0.23877,0.649,0.886,26,0.997,"carboxyamidotriazole",0.0525662781129492,0.00130484168834428,FALSE +"proteomics","Pearson.est","CC chemokine receptor antagonist",0.50359,1.38,0.13,129,0.643,"UNBS.5162, SB.225002, ZK811752",0.886056647693163,0.191789027075778,FALSE +"proteomics","Pearson.est","CDK inhibitor",-0.18259,-0.452,0.995,981,1,"alvocidib, dinaciclib, TG.02, kenpaullone, BMS.387032, indirubin, CR8..R., arcyriaflavin.a",0.00217691925427455,0,FALSE +"proteomics","Pearson.est","CHK inhibitor",-0.64686,-1.65,0.0363,1052,0.563,"AZD7762, CHIR.124, SCH.900776, LY2603618, LY2606368",1.44009337496389,0.249491605148654,FALSE +"proteomics","Pearson.est","cyclooxygenase inhibitor",-0.34465,-0.87,0.62,1220,1,"ketoprofen, FR.122047, FK.3311, tryptanthrin, naproxen, indoprofen",0.207608310501746,0,FALSE +"proteomics","Pearson.est","cytochrome P450 inhibitor",-0.46402,-1.18,0.272,1179,0.68,"cobicistat, itraconazole",0.565431095965801,0.167491087293764,FALSE +"proteomics","Pearson.est","DNA alkylating agent",-0.3084,-0.766,0.73,1013,0.974,"satraplatin, TH.302, melphalan, cisplatin, estramustine, ifosfamide, dacarbazine",0.136677139879544,0.0114410431213845,FALSE +"proteomics","Pearson.est","DNA inhibitor",0.43601,1.2,0.268,344,0.802,"carboplatin, metronidazole, mechlorethamine, teroxirone, oxaliplatin, sangivamycin, tirapazamine, carmustine, chlorambucil, pibenzimol",0.571865205971211,0.0958256317158365,FALSE +"proteomics","Pearson.est","DNA methyltransferase inhibitor",-0.56815,-1.42,0.099,1219,0.466,"RG108, fdcyd, azacitidine",1.00436480540245,0.33161408331,FALSE +"proteomics","Pearson.est","DNA polymerase inhibitor",-0.26746,-0.677,0.863,931,0.921,"menadione, adefovir.dipivoxil, cidofovir, cephalomannine",0.0639892042847904,0.0357403698031511,FALSE +"proteomics","Pearson.est","DNA synthesis inhibitor",-0.17625,-0.444,0.995,1110,0.992,"estramustine.phosphate, cisplatin, altretamine",0.00217691925427455,0.00348832784582135,FALSE +"proteomics","Pearson.est","dopamine receptor antagonist",0.26079,0.717,0.815,1,1,"thioproperazine",0.0888423912600234,0,FALSE +"proteomics","Pearson.est","estrogen receptor agonist",0.33985,0.916,0.543,292,1,"estrone, erteberel, levonorgestrel, estradiol.cypionate",0.265200170411153,0,FALSE +"proteomics","Pearson.est","estrogen receptor antagonist",0.3939,1.07,0.334,880,0.891,"fulvestrant, toremifene, tamoxifen, clomifene, danazol, raloxifene",0.476253533188435,0.0501222959631252,FALSE +"proteomics","Pearson.est","FGFR inhibitor",0.30912,0.802,0.641,339,1,"dovitinib, nintedanib, AZD4547, lenvatinib, erdafitinib, regorafenib",0.193141970481183,0,FALSE +"proteomics","Pearson.est","FLT3 inhibitor",0.25441,0.688,0.829,108,1,"dovitinib, tyrphostin.AG.1296, ENMD.2076",0.0814454694497265,0,FALSE +"proteomics","Pearson.est","glucocorticoid receptor agonist",0.31865,0.876,0.589,257,1,"beclomethasone.dipropionate, hydrocortisone, fluticasone.propionate, desonide, triamcinolone, dexamethasone.acetate",0.229884705212898,0,FALSE +"proteomics","Pearson.est","glutamate receptor antagonist",-0.52247,-1.33,0.171,1040,0.501,"CPP, diazooxonorleucine, SIB.1757, ACDPP, MTPG, latrepirdine, LY456236",0.767003889607846,0.300162274132754,FALSE +"proteomics","Pearson.est","glycogen synthase kinase inhibitor",-0.59749,-1.47,0.0721,1080,0.449,"kenpaullone, indirubin, LY2090314, AZD2858, GSK.3.inhibitor.IX",1.14206473528057,0.347753658996677,FALSE +"proteomics","Pearson.est","growth factor receptor inhibitor",0.55679,1.53,0.0956,225,0.676,"PHA.848125, danusertib",1.0195421077239,0.170053304058364,FALSE +"proteomics","Pearson.est","HCV inhibitor",-0.64199,-1.63,0.039,1272,0.381,"PSI.7976, embelin, Ro.9187",1.4089353929735,0.419075024324381,FALSE +"proteomics","Pearson.est","HDAC inhibitor",-0.60905,-1.54,0.0638,966,0.354,"ACY.1215, resminostat, scriptaid, dacinostat, belinostat, mocetinostat, givinostat, pyroxamide, RG2833, tacedinaline, vorinostat, M.344, entinostat, PCI.24781, romidepsin, R306465, panobinostat, nexturastat.a, JNJ.26481585, SB.939",1.19517932127884,0.450996737974212,FALSE +"proteomics","Pearson.est","histamine receptor antagonist",-0.55943,-1.39,0.127,923,0.453,"BF2.649, cimetidine, cyproheptadine, famotidine, astemizole, zolantidine, tiotidine, terfenadine, levocetirizine, ICI.162846, tecastemizole, chloropyramine",0.896196279044043,0.343901797987168,FALSE +"proteomics","Pearson.est","HMGCR inhibitor",-0.46003,-1.15,0.288,1081,0.707,"mevastatin, simvastatin",0.540607512240769,0.150580586203101,FALSE +"proteomics","Pearson.est","HSP inhibitor",-0.48905,-1.22,0.253,999,0.628,"NVP.AUY922, tanespimycin, XL888, SNX.5422, guanidine, alvespimycin, VER.49009, KW.2478",0.596879478824182,0.202040356262804,FALSE +"proteomics","Pearson.est","JAK inhibitor",-0.36557,-0.93,0.505,1384,0.987,"LY2784544, pacritinib, atiprimod",0.296708621881339,0.00568284733036327,FALSE +"proteomics","Pearson.est","KIT inhibitor",-0.28892,-0.741,0.775,905,0.878,"tandutinib, KI.8751, sunitinib, cediranib, motesanib, imatinib, midostaurin, vatalanib, telatinib",0.11069829749369,0.0565054840938974,FALSE +"proteomics","Pearson.est","MDM inhibitor",0.54338,1.45,0.117,117,0.591,"idasanutlin, nutlin.3, AMG.232",0.931814138253838,0.228412519118745,FALSE +"proteomics","Pearson.est","MEK inhibitor",-0.29678,-0.748,0.757,1426,0.954,"nobiletin, BIX.02188",0.120904120499927,0.0204516252959049,FALSE +"proteomics","Pearson.est","MET inhibitor",-0.62663,-1.56,0.0598,1243,0.357,"AMG458, INC.280",1.22329881601159,0.447331783887807,FALSE +"proteomics","Pearson.est","microtubule inhibitor",0.23435,0.645,0.876,1111,0.968,"vinblastine, vinflunine, D.64131, secnidazole, colchicine, cytochalasin.b, cabazitaxel, triclabendazole, podophyllotoxin, estramustine.phosphate",0.0574958938319193,0.0141246426916063,FALSE +"proteomics","Pearson.est","mTOR inhibitor",0.37342,1.01,0.419,338,0.978,"AZD2014, ku.0063794, MLN0128, torin.1, voxtalisib, WYE.125132, XL388, SB.2343, PP242, PF.04691502, OSI.027, GDC.0980, NVP.BEZ235",0.377785977033705,0.00966114521239857,FALSE +"proteomics","Pearson.est","NFkB pathway inhibitor",-0.30507,-0.761,0.74,1253,0.957,"IKK.2.inhibitor.V, bortezomib, Ro.106.9920",0.130768280269024,0.0190880622231565,FALSE +"proteomics","Pearson.est","opioid receptor agonist",-0.31367,-0.79,0.717,1330,1,"salvinorin.a",0.1444808443322,0,FALSE +"proteomics","Pearson.est","p38 MAPK inhibitor",-0.40226,-1.01,0.466,1002,0.878,"SB.239063, CMPD.1, VX.702, TAK.715",0.33161408331,0.0565054840938974,FALSE +"proteomics","Pearson.est","PARP inhibitor",-0.42722,-1.09,0.346,1073,0.771,"PJ.34, endo.IWR.1, E7449",0.460923901207223,0.112945621949043,FALSE +"proteomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.23385,-0.591,0.942,1282,0.966,"vatalanib, trapidil, telatinib, orantinib",0.0259490972071227,0.0150228735845067,FALSE +"proteomics","Pearson.est","phosphatase inhibitor",0.24423,0.651,0.881,127,1,"GSK2830371, bis.maltolato.oxovanadium.IV.",0.0550240915879521,0,FALSE +"proteomics","Pearson.est","phosphodiesterase inhibitor",-0.55705,-1.41,0.117,961,0.448,"EMD.53998, anagrelide, enoximone, papaverine, cilostamide, GSK256066, zardaverine, YM.976",0.931814138253838,0.348721986001856,FALSE +"proteomics","Pearson.est","PI3K inhibitor",0.32388,0.859,0.606,338,1,"GDC.0941, idelalisib, ZSTK.474, voxtalisib, SB.2343, buparlisib, PI3K.IN.2, PF.04691502, GDC.0980, NVP.BEZ235",0.217527375833714,0,FALSE +"proteomics","Pearson.est","PLK inhibitor",0.74532,2.04,0.00265,374,0.0831,"NMS.1286937, volasertib, GW.843682X, HMN.214, rigosertib, BI.2536, GSK461364",2.57675412606319,1.08039897621589,TRUE +"proteomics","Pearson.est","potassium channel blocker",-0.32325,-0.803,0.691,974,1,"meglitinide, oleoylethanolamide, dofetilide",0.160521952625802,0,FALSE +"proteomics","Pearson.est","PPAR receptor agonist",-0.30568,-0.768,0.738,1055,0.997,"GW.501516, oleoylethanolamide, S26948",0.131943638176958,0.00130484168834428,FALSE +"proteomics","Pearson.est","progesterone receptor agonist",0.49639,1.36,0.141,281,0.601,"nomegestrol.acetate, tanaproget, levonorgestrel, norethindrone",0.85078088734462,0.22112552799726,FALSE +"proteomics","Pearson.est","proteasome inhibitor",-0.69711,-1.76,0.0185,1053,0.384,"oprozomib, ixazomib, ONX.0914, bortezomib, carfilzomib, ixazomib.citrate",1.73282827159699,0.415668775632469,FALSE +"proteomics","Pearson.est","protein synthesis inhibitor",0.29808,0.798,0.682,365,1,"harringtonine, clofoctol, anguidine, mercaptopurine, clindamycin.phosphate, bruceantin, chloramphenicol.palmitate, cycloheximide",0.166215625343521,0,FALSE +"proteomics","Pearson.est","protein tyrosine kinase inhibitor",-0.3089,-0.773,0.75,948,1,"BMS.599626, tyrphostin.A9, NVP.TAE226, CP.724714, AV.412, rheochrysidin",0.1249387366083,0,FALSE +"proteomics","Pearson.est","RAF inhibitor",-0.53101,-1.37,0.16,1181,0.459,"CEP.32496, vemurafenib, GDC.0879, dabrafenib",0.795880017344075,0.338187314462739,FALSE +"proteomics","Pearson.est","RET tyrosine kinase inhibitor",-0.57673,-1.43,0.107,1358,0.488,"apatinib, vandetanib",0.97061622231479,0.311580177997289,FALSE +"proteomics","Pearson.est","retinoid receptor agonist",0.27461,0.736,0.757,247,1,"adapalene, fenretinide, LE.135",0.120904120499927,0,FALSE +"proteomics","Pearson.est","ribonucleotide reductase inhibitor",0.33582,0.91,0.543,183,1,"cytarabine, hydroxyurea, pentostatin",0.265200170411153,0,FALSE +"proteomics","Pearson.est","serotonin receptor agonist",-0.30814,-0.769,0.739,1186,1,"aripiprazole, ipsapirone",0.131355561605174,0,FALSE +"proteomics","Pearson.est","serotonin receptor antagonist",-0.34005,-0.867,0.61,1185,1,"RS.16566, aripiprazole, tropisetron, lerisetron, SB.228357",0.214670164989233,0,FALSE +"proteomics","Pearson.est","sodium channel blocker",-0.32741,-0.836,0.649,1226,1,"triamterene, lappaconite, mexiletine",0.187755303199631,0,FALSE +"proteomics","Pearson.est","src inhibitor",-0.29137,-0.745,0.779,835,0.914,"TG.100572, PP.1, ZM.306416, bosutinib, saracatinib, PP.2",0.108462542327436,0.0390538042661686,FALSE +"proteomics","Pearson.est","sterol demethylase inhibitor",0.76232,2.05,0.00248,149,0.158,"chlormidazole, sulconazole, posaconazole, lanoconazole",2.60554831917378,0.801342913045577,TRUE +"proteomics","Pearson.est","TGF beta receptor inhibitor",-0.64087,-1.61,0.0594,1222,0.361,"SB.431542, D.4476, repsox, LY2109761",1.22621355501881,0.442492798094342,FALSE +"proteomics","Pearson.est","thymidylate synthase inhibitor",-0.39674,-0.98,0.474,1437,0.908,"doxifluridine",0.324221658325915,0.0419141514789149,FALSE +"proteomics","Pearson.est","topoisomerase inhibitor",0.25839,0.705,0.818,229,1,"mitoxantrone, idarubicin, dexrazoxane, etoposide.phosphate, epirubicin, TAS.103, doxorubicin",0.087246696328677,0,FALSE +"proteomics","Pearson.est","tubulin polymerization inhibitor",0.23959,0.652,0.896,271,1,"verubulin, fenbendazole, BNC105, vinblastine, vindesine, mebendazole",0.0476919903378748,0,FALSE +"proteomics","Pearson.est","tyrosine kinase inhibitor",-0.28636,-0.718,0.808,910,0.891,"tyrphostin.AG.99, sunitinib, BMS.599626, tyrphostin.A9, NVP.TAE226, AMG.208, CP.724714, AV.412, rheochrysidin, apatinib, vandetanib",0.0925886392254138,0.0501222959631252,FALSE +"proteomics","Pearson.est","VEGFR inhibitor",-0.29288,-0.747,0.771,1259,0.933,"MGCD.265, vatalanib, AEE788, lucitanib, BMS.690514, vandetanib, telatinib, orantinib",0.112945621949043,0.0301183562535,FALSE +"proteomics","Pearson.est","vitamin D receptor agonist",-0.49135,-1.26,0.224,993,0.578,"ercalcitriol, paricalcitol, tacalcitol, maxacalcitol, calcitriol",0.649751981665837,0.238072161579471,FALSE +"metabolomics","Pearson.est","EGFR inhibitor",-0.40853,-1.06,0.383,1048,0.713,"gefitinib, erlotinib, tucatinib, AEE788, WZ8040, dacomitinib, BMS.599626, BMS.690514, BIBU.1361, vandetanib, canertinib, neratinib, PD.168393, OSI.420, afatinib, pelitinib, brigatinib, TAK.285, osimertinib, PD.153035",0.416801226031377,0.146910470148134,FALSE +"metabolomics","Pearson.est","Abl kinase inhibitor",-0.62703,-1.63,0.0538,1070,0.283,"bafetinib, flumatinib, tozasertib, dasatinib, nilotinib, GZD824, metatinib, ponatinib",1.26921772433361,0.54821356447571,FALSE +"metabolomics","Pearson.est","acetylcholine receptor agonist",0.61238,1.55,0.0845,186,0.389,"pilocarpine, oxiracetam, nefiracetam",1.07314329105031,0.410050398674292,FALSE +"metabolomics","Pearson.est","acetylcholine receptor antagonist",-0.22665,-0.587,0.929,1093,0.975,"darifenacin, dicycloverine",0.0319842860063582,0.0109953843014632,FALSE +"metabolomics","Pearson.est","adenosine receptor antagonist",0.3039,0.795,0.693,82,0.941,"SCH.58261",0.159266765388193,0.0264103765727431,FALSE +"metabolomics","Pearson.est","adrenergic receptor agonist",-0.37758,-0.983,0.47,1150,0.695,"epinephrine, clenbuterol, A61603, isoetharine, metaraminol, terbutaline",0.327902142064283,0.158015195409886,FALSE +"metabolomics","Pearson.est","adrenergic receptor antagonist",0.37698,0.962,0.471,316,0.894,"prazosin, propranolol, atenolol......, naftidrofuryl, oxprenolol, imiloxan",0.326979092871104,0.0486624812040823,FALSE +"metabolomics","Pearson.est","AKT inhibitor",0.23808,0.626,0.905,219,1,"AT7867, ONC201",0.0433514207947967,0,FALSE +"metabolomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.50162,-1.3,0.169,1033,0.506,"alectinib, GW.788388, AZD3463, AP26113, brigatinib, CEP.37440",0.772113295386326,0.295849483160201,FALSE +"metabolomics","Pearson.est","androgen receptor antagonist",0.77336,2.02,0.00789,264,0.0464,"bicalutamide, enzalutamide, nilutamide, RU.58841",2.10292299679058,1.33348201944512,TRUE +"metabolomics","Pearson.est","antioxidant",0.31137,0.791,0.715,999,0.859,"trolox, mesna, chlorogenic.acid, benfotiamine, taurine, rutin",0.145693958198919,0.0660068361687577,FALSE +"metabolomics","Pearson.est","AP inhibitor",-0.3765,-0.974,0.457,1135,0.686,"embelin, LCL.161",0.34008379993015,0.163675884293248,FALSE +"metabolomics","Pearson.est","ATPase inhibitor",0.59873,1.56,0.0913,267,0.434,"k.strophanthidin, rabeprazole, evodiamine, digitoxigenin, oligomycin.a, digitoxin",1.0395292224657,0.362510270487489,FALSE +"metabolomics","Pearson.est","Aurora kinase inhibitor",0.20118,0.528,0.975,70,0.994,"PHA.680632, CCT129202",0.0109953843014632,0.00261361560268669,FALSE +"metabolomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.35427,-0.906,0.556,1294,0.692,"dirithromycin, tedizolid",0.254925208417942,0.159893905543242,FALSE +"metabolomics","Pearson.est","bacterial DNA gyrase inhibitor",0.41822,1.08,0.339,177,0.762,"norfloxacin, finafloxacin, nadifloxacin",0.469800301796918,0.1180450286604,FALSE +"metabolomics","Pearson.est","BCL inhibitor",-0.43591,-1.11,0.314,1183,0.683,"gossypol, HA14.1, navitoclax",0.503070351926785,0.165579296318467,FALSE +"metabolomics","Pearson.est","Bcr.Abl kinase inhibitor",-0.68737,-1.78,0.0225,1070,0.204,"bafetinib, flumatinib, tozasertib, dasatinib, nilotinib, GZD824, metatinib, ponatinib",1.64781748188864,0.690369832574101,TRUE +"metabolomics","Pearson.est","benzodiazepine receptor agonist",0.50126,1.31,0.181,256,0.57,"eprinomectin, bentazepam, nefiracetam, piperazine",0.742321425130815,0.244125144327509,FALSE +"metabolomics","Pearson.est","bromodomain inhibitor",0.36685,0.942,0.526,919,0.857,"I.BET.762, I.BET151, JQ1...., OTX015, bromosporine, PFI.1",0.279014255846261,0.0670191780768018,FALSE +"metabolomics","Pearson.est","calcium channel blocker",-0.18645,-0.481,0.986,895,1,"efonidipine.monoethanolate, mibefradil, SR.33805, tetrandrine, SKF.96365, penfluridol",0.0061230850587888,0,FALSE +"metabolomics","Pearson.est","CC chemokine receptor antagonist",0.29746,0.77,0.743,169,0.864,"SB.225002, PF.04136309",0.129011186239425,0.0634862575211067,FALSE +"metabolomics","Pearson.est","CDK inhibitor",-0.47432,-1.22,0.22,1065,0.578,"kenpaullone, palbociclib, alvocidib, arcyriaflavin.a, dinaciclib, ribociclib, AT.7519, abemaciclib, P276.00",0.657577319177794,0.238072161579471,FALSE +"metabolomics","Pearson.est","CHK inhibitor",-0.71577,-1.84,0.0153,1297,0.181,"LY2603618, AZD7762, SCH.900776, LY2606368",1.8153085691824,0.742321425130815,TRUE +"metabolomics","Pearson.est","cyclooxygenase inhibitor",0.24554,0.635,0.892,523,1,"aspirin, sulfasalazine, pterostilbene, phenazone, amfenac, AM.404, naproxen, ramifenazone, phenylbutazone, tepoxalin, piroxicam, meloxicam",0.0496351456238769,0,FALSE +"metabolomics","Pearson.est","cytochrome P450 inhibitor",-0.41748,-1.07,0.387,1402,0.725,"itraconazole",0.412289034981089,0.139661993429006,FALSE +"metabolomics","Pearson.est","DNA alkylating agent",-0.37591,-0.985,0.439,1261,0.716,"melphalan, ifosfamide, cisplatin, estramustine",0.357535479757879,0.145086977692144,FALSE +"metabolomics","Pearson.est","DNA inhibitor",0.51516,1.33,0.157,182,0.579,"carboplatin, mechlorethamine, tirapazamine, bendamustine, metronidazole, nimorazole",0.804100347590766,0.237321436272564,FALSE +"metabolomics","Pearson.est","DNA methyltransferase inhibitor",-0.6451,-1.63,0.0382,1216,0.283,"fdcyd, decitabine, azacitidine",1.41793663708829,0.54821356447571,FALSE +"metabolomics","Pearson.est","DNA polymerase inhibitor",0.41261,1.07,0.382,283,0.743,"famciclovir, foscarnet, cephalomannine",0.417936637088291,0.129011186239425,FALSE +"metabolomics","Pearson.est","DNA synthesis inhibitor",0.30546,0.791,0.704,322,0.859,"artesunate, azodicarbonamide, CB.10.277, artemisinin, nelarabine, altretamine",0.152427340857888,0.0660068361687577,FALSE +"metabolomics","Pearson.est","dopamine receptor antagonist",0.52613,1.34,0.157,125,0.617,"thioproperazine, clebopride, remoxipride, raclopride",0.804100347590766,0.209714835966758,FALSE +"metabolomics","Pearson.est","estrogen receptor agonist",0.55447,1.41,0.125,170,0.539,"ethinyl.estradiol, estrone, erteberel, levonorgestrel",0.903089986991944,0.268411234813261,FALSE +"metabolomics","Pearson.est","estrogen receptor antagonist",0.35014,0.893,0.578,197,0.885,"clomifene, raloxifene",0.238072161579471,0.0530567293021746,FALSE +"metabolomics","Pearson.est","FGFR inhibitor",-0.39904,-1.03,0.404,1146,0.712,"MK.2461, erdafitinib, lucitanib",0.393618634889395,0.147520006363144,FALSE +"metabolomics","Pearson.est","FLT3 inhibitor",-0.31096,-0.808,0.684,1298,0.809,"midostaurin, lestaurtinib, ponatinib, gilteritinib",0.164943898279884,0.0920514783877277,FALSE +"metabolomics","Pearson.est","glucocorticoid receptor agonist",0.62138,1.6,0.0757,513,0.543,"hydrocortisone, prednisolone, desonide, methylprednisolone, ciclesonide, fluticasone.propionate, dexamethasone.acetate, piretanide, halcinonide, triamcinolone.acetonide, fluocinolone.acetonide, rimexolone, flumethasone.pivalate, betamethasone, prednisolone.acetate, beclomethasone.dipropionate, difluprednate, triamcinolone",1.12090412049993,0.265200170411153,FALSE +"metabolomics","Pearson.est","glutamate receptor antagonist",0.32341,0.839,0.652,88,0.958,"tiletamine, latrepirdine",0.18575240426808,0.0186344909214556,FALSE +"metabolomics","Pearson.est","glycogen synthase kinase inhibitor",-0.34427,-0.886,0.571,1019,0.705,"LY2090314, kenpaullone, tideglusib, GSK.3.inhibitor.IX",0.243363891754152,0.151810883008601,FALSE +"metabolomics","Pearson.est","growth factor receptor inhibitor",-0.49025,-1.28,0.19,1154,0.508,"AZD3463, GSK1838705A, lestaurtinib",0.721246399047171,0.294136287716081,FALSE +"metabolomics","Pearson.est","HCV inhibitor",0.6066,1.58,0.0642,20,0.471,"PSI.7976, narlaprevir",1.19246497193115,0.326979092871104,FALSE +"metabolomics","Pearson.est","HDAC inhibitor",-0.57671,-1.5,0.0885,1084,0.377,"AR.42, trichostatin.a, mocetinostat, givinostat, PCI.24781, SB.939, nexturastat.a, entinostat, dacinostat, M.344, belinostat, resminostat, panobinostat, R306465, JNJ.26481585, RG2833",1.05305672930217,0.423658649794207,FALSE +"metabolomics","Pearson.est","histamine receptor antagonist",0.35525,0.9,0.559,225,0.907,"ranitidine, nizatidine, epinastine, terfenadine, famotidine",0.252588192113577,0.0423927129399047,FALSE +"metabolomics","Pearson.est","HMGCR inhibitor",0.46066,1.21,0.239,14,0.591,"fluvastatin",0.621602099051862,0.228412519118745,FALSE +"metabolomics","Pearson.est","HSP inhibitor",-0.37371,-0.958,0.48,1005,0.649,"KW.2478, ganetespib, BIIB021, SNX.5422, NVP.AUY922, VER.49009",0.318758762624413,0.187755303199631,FALSE +"metabolomics","Pearson.est","JAK inhibitor",0.32284,0.831,0.676,223,0.938,"TG.101348, AZD1480, CEP.33779, WHI.P154, filgotinib",0.170053304058364,0.0277971616209356,FALSE +"metabolomics","Pearson.est","KIT inhibitor",-0.54617,-1.36,0.135,1176,0.469,"sunitinib, vatalanib, dasatinib, telatinib, midostaurin, pazopanib, KI.8751, motesanib",0.869666231504994,0.328827157284917,FALSE +"metabolomics","Pearson.est","MDM inhibitor",0.90559,2.37,0,105,0.000946,"idasanutlin, CGM097, nutlin.3, RITA, AMG.232",Inf,3.02410886359821,TRUE +"metabolomics","Pearson.est","MEK inhibitor",-0.56892,-1.45,0.108,1164,0.428,"arctigenin, AS.703026, selumetinib, PD.184352, TAK.733, AZD8330, nobiletin, trametinib, BIX.02188, cobimetinib",0.96657624451305,0.368556230986828,FALSE +"metabolomics","Pearson.est","MET inhibitor",-0.77872,-2.01,0.00197,1158,0.114,"PHA.665752, PF.04217903, LY2801653, NVP.BVU972, INC.280",2.70553377383841,0.943095148663527,TRUE +"metabolomics","Pearson.est","microtubule inhibitor",0.2276,0.578,0.923,508,0.989,"cabazitaxel, vinblastine, colchicine, triclabendazole, secnidazole",0.0347982989740879,0.0048037084028206,FALSE +"metabolomics","Pearson.est","mTOR inhibitor",-0.25175,-0.651,0.882,1275,0.939,"deforolimus, NVP.BEZ235, torin.2, everolimus, temsirolimus",0.0545314148681803,0.0273344077338891,FALSE +"metabolomics","Pearson.est","NFkB pathway inhibitor",-0.29861,-0.76,0.734,1362,0.86,"bortezomib, Ro.106.9920",0.134303940083929,0.0655015487564323,FALSE +"metabolomics","Pearson.est","opioid receptor agonist",-0.29281,-0.746,0.761,1320,0.86,"cebranopadol",0.118615343229427,0.0655015487564323,FALSE +"metabolomics","Pearson.est","p38 MAPK inhibitor",0.50646,1.28,0.203,349,0.54,"talmapimod, SB.242235, skepinone.l",0.692503962086787,0.267606240177031,FALSE +"metabolomics","Pearson.est","PARP inhibitor",-0.27739,-0.707,0.797,1072,0.891,"PJ.34, olaparib, talazoparib",0.0985416786038876,0.0501222959631252,FALSE +"metabolomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.45321,-1.18,0.249,1176,0.584,"sunitinib, vatalanib, dasatinib, telatinib, pazopanib, SU014813, KI.8751, motesanib, ponatinib",0.603800652904264,0.233587152887601,FALSE +"metabolomics","Pearson.est","phosphatase inhibitor",0.31754,0.804,0.672,149,0.957,"bis.maltolato.oxovanadium.IV., GSK2830371",0.172630726946175,0.0190880622231565,FALSE +"metabolomics","Pearson.est","phosphodiesterase inhibitor",-0.50864,-1.33,0.165,884,0.487,"EMD.53998, papaverine, GSK256066, trequinsin, YM.976, zardaverine",0.782516055786094,0.312471038785366,FALSE +"metabolomics","Pearson.est","PI3K inhibitor",-0.17936,-0.467,0.992,877,0.989,"ZSTK.474, LY3023414, PI.828, taselisib, GSK2126458, buparlisib, BGT226, alpelisib, CH5132799, GDC.0980, CUDC.907, NVP.BEZ235, TG100.115",0.00348832784582135,0.0048037084028206,FALSE +"metabolomics","Pearson.est","PLK inhibitor",0.30273,0.792,0.713,243,0.914,"HMN.214, NMS.1286937",0.146910470148134,0.0390538042661686,FALSE +"metabolomics","Pearson.est","potassium channel blocker",-0.39294,-1.03,0.395,1223,0.712,"mepivacaine, dofetilide",0.40340290437354,0.147520006363144,FALSE +"metabolomics","Pearson.est","PPAR receptor agonist",0.49432,1.29,0.19,588,0.563,"fenofibrate, pterostilbene, clofibrate, S26948, oleoylethanolamide",0.721246399047171,0.249491605148654,FALSE +"metabolomics","Pearson.est","progesterone receptor agonist",0.4685,1.2,0.242,213,0.572,"norethindrone, levonorgestrel, norgestrel",0.616184634019569,0.242603971206976,FALSE +"metabolomics","Pearson.est","proteasome inhibitor",-0.64676,-1.67,0.0296,1180,0.315,"ixazomib.citrate, bortezomib, carfilzomib",1.52870828894106,0.501689446210399,FALSE +"metabolomics","Pearson.est","protein synthesis inhibitor",0.36366,0.945,0.485,360,0.889,"cycloheximide, mercaptopurine, bruceantin, clofoctol, harringtonine, anguidine, chloramphenicol.palmitate, tedizolid.phosphate",0.314258261397736,0.0510982390297863,FALSE +"metabolomics","Pearson.est","protein tyrosine kinase inhibitor",-0.3705,-0.967,0.464,1101,0.676,"rheochrysidin, BMS.599626, AV.412, NVP.TAE226",0.333482019445119,0.170053304058364,FALSE +"metabolomics","Pearson.est","RAF inhibitor",-0.72337,-1.88,0.0113,1040,0.193,"sorafenib, PLX.4720, CEP.32496, LGX818, SB.590885, GDC.0879, AZ.628, TAK.632, RAF265, dabrafenib, vemurafenib",1.94692155651658,0.714442690992226,TRUE +"metabolomics","Pearson.est","RET tyrosine kinase inhibitor",-0.61902,-1.61,0.0568,907,0.277,"apatinib, sorafenib, vandetanib, sunitinib",1.24565166428898,0.557520230935551,FALSE +"metabolomics","Pearson.est","retinoid receptor agonist",-0.36603,-0.965,0.483,1184,0.658,"CD.437, LE.135, tamibarotene, adarotene",0.316052869248488,0.181774106386044,FALSE +"metabolomics","Pearson.est","ribonucleotide reductase inhibitor",-0.39033,-0.992,0.432,1151,0.729,"fludarabine, hydroxyurea, triapine, clofarabine",0.364516253185088,0.137272471682025,FALSE +"metabolomics","Pearson.est","serotonin receptor agonist",0.57338,1.49,0.0861,2,0.438,"aripiprazole",1.06499684854635,0.3585258894959,FALSE +"metabolomics","Pearson.est","serotonin receptor antagonist",0.37902,0.976,0.475,248,0.907,"aripiprazole, pirenperone, SB.200646, lurasidone",0.323306390375133,0.0423927129399047,FALSE +"metabolomics","Pearson.est","sodium channel blocker",0.19062,0.489,0.983,404,0.983,"A.803467, cibenzoline, brivaracetam, butamben",0.00744648216786438,0.00744648216786438,FALSE +"metabolomics","Pearson.est","src inhibitor",-0.5731,-1.5,0.0886,1112,0.377,"PP.2, dasatinib, PP.1, saracatinib, TG.100572",1.05256627811295,0.423658649794207,FALSE +"metabolomics","Pearson.est","sterol demethylase inhibitor",0.66737,1.74,0.0285,442,0.327,"terconazole, ketoconazole, posaconazole, lanoconazole, chlormidazole",1.54515513999149,0.485452247339714,FALSE +"metabolomics","Pearson.est","TGF beta receptor inhibitor",0.23797,0.623,0.91,367,0.976,"adaprev, SB.525334",0.0409586076789064,0.0105501823333082,FALSE +"metabolomics","Pearson.est","thymidylate synthase inhibitor",-0.54377,-1.4,0.116,1139,0.437,"trifluridine, raltitrexed, capecitabine, doxifluridine",0.935542010773082,0.359518563029578,FALSE +"metabolomics","Pearson.est","topoisomerase inhibitor",-0.54843,-1.43,0.11,1038,0.421,"beta.lapachone, licochalcone.a, fleroxacin, SN.38, teniposide, exatecan.mesylate, topotecan, doxorubicin, camptothecin, genz.644282, rubitecan, etoposide, daunorubicin, irinotecan",0.958607314841775,0.375717904164332,FALSE +"metabolomics","Pearson.est","tubulin polymerization inhibitor",0.47583,1.21,0.237,438,0.591,"nocodazole, epothilone.b, indibulin, taltobulin, KX2.391, BNC105, flubendazole, dolastatin.10, vinorelbine, oxibendazole, mebendazole, vinblastine, ABT.751, verubulin, CYT.997, epothilone.d",0.625251653989896,0.228412519118745,FALSE +"metabolomics","Pearson.est","tyrosine kinase inhibitor",-0.36147,-0.914,0.535,1040,0.699,"sorafenib, bafetinib, rheochrysidin, BMS.599626, AV.412, vandetanib, 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proteomics",2,1,"proteomics",NA diff --git a/Examples/Fig4/GSEA/GSEA_results.csv b/Examples/Fig4/GSEA/GSEA_results.csv new file mode 100644 index 0000000..ead47b5 --- /dev/null +++ b/Examples/Fig4/GSEA/GSEA_results.csv @@ -0,0 +1,370 @@ +"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"transcriptomics","Log2FC","KEGG_ABC_TRANSPORTERS",0.23561,0.676,0.941,7191,0.988,"ABCA12, ABCB8, ABCB9, ABCA13, ABCD1, ABCC3, ABCA1, ABCA2, ABCB11, ABCC10, ABCD4, ABCA4, ABCC5, ABCA5, TAP2, ABCC11, ABCG1, ABCB6, ABCG2",0.0264103765727431,0.00524305541237188,FALSE +"transcriptomics","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.36169,1.06,0.344,5916,0.767,"PIK3R2, IKBKB, MAPK3, RPS6KB2, PML, RARA, PIK3CA, JUP, STAT5B, STAT3, BRAF, RELA, TCF7L1, RUNX1, BAD, PIM1, PIK3R3, CCNA1, STAT5A, MAPK1, PIK3R5, PIK3CB, CEBPA",0.46344155742847,0.115204636051019,FALSE 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CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, JUP, DSP, ITGA3, CACNB2, DAG1, DSG2, ITGA2B, DSC2, TCF7L1, PKP2",0.45717457304082,0.115204636051019,FALSE +"transcriptomics","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.50501,-1.82,0.0375,14596,0.175,"UGDH, MIOX, ALDH3A2, UGT2A1, ALDH1B1, ALDH7A1, ALDH9A1",1.42596873227228,0.756961951313706,TRUE +"transcriptomics","Log2FC","KEGG_ASTHMA",-0.34369,-1.16,0.262,17122,0.594,"IL13, EPX, IL5",0.581698708680255,0.226213555018806,FALSE +"transcriptomics","Log2FC","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.42092,-1.49,0.0682,16806,0.282,"IFNA21, PRF1, IFNA13, IL5, CTLA4",1.16621562534352,0.549750891680639,FALSE +"transcriptomics","Log2FC","KEGG_AXON_GUIDANCE",0.44776,1.31,0.0991,5666,0.806,"EPHA1, PAK6, PLXNB2, EPHB3, PLXNB1, PLXNA3, SEMA4A, EFNA1, FES, SEMA3E, EFNA4, SEMA4B, RAC2, LIMK2, SEMA7A, EFNA3, SRGAP3, MAPK3, NTN4, RHOD, UNC5B, NTN1, PLXNB3, CDK5, EPHB4, MET, PLXNA2, EPHB6, SEMA3B, ABLIM3, NCK2, EPHB2, SEMA4F, SRGAP1, UNC5A, ABLIM2, EFNB3, EFNB1, ABLIM1, SEMA5B, CHP1, PPP3CA, PAK2, SEMA4C, SEMA4D, NGEF, SEMA3C, LIMK1, NCK1, SEMA5A, RASA1, RND1, ROBO3, RAC1, PAK1, PAK4, MAPK1, NFATC1",1.00392634551472,0.0936649581949093,FALSE +"transcriptomics","Log2FC","KEGG_BASAL_CELL_CARCINOMA",0.3741,1.08,0.317,4115,0.763,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, WNT4, DVL3, BMP2, WNT10A, GLI3, TCF7L1, FZD4, DVL2, WNT11",0.498940737782249,0.11747546204512,FALSE +"transcriptomics","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.36638,-1.28,0.146,18395,0.433,"TBPL1, TAF9B, TBP, GTF2H2, TAF9, TAF1L",0.835647144215563,0.363512103646635,FALSE +"transcriptomics","Log2FC","KEGG_BASE_EXCISION_REPAIR",0.30931,0.894,0.647,912,0.962,"SMUG1, POLD4, POLB",0.1890957193313,0.0168249279621871,FALSE +"transcriptomics","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.24897,-0.86,0.67,17472,0.952,"ALDH1B1, ALDH7A1, SMS, ALDH9A1",0.173925197299174,0.0213630516155257,FALSE +"transcriptomics","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.30636,0.89,0.634,3986,0.964,"ACOT4, TECR, ACAA1, ELOVL6, ACOX1, SCD5",0.197910742118267,0.0159229660971692,FALSE +"transcriptomics","Log2FC","KEGG_BLADDER_CANCER",0.38783,1.12,0.262,4516,0.711,"CDH1, ERBB2, MMP9, TYMP, VEGFB, MAPK3, EGFR, E2F1, DAPK1, THBS1, FGFR3, BRAF, PGF, VEGFA, DAPK2",0.581698708680255,0.148130399270234,FALSE +"transcriptomics","Log2FC","KEGG_BUTANOATE_METABOLISM",0.28276,0.819,0.765,2472,1,"ABAT, HMGCL, BDH1, HMGCS1, ACADS, EHHADH",0.116338564846382,0,FALSE +"transcriptomics","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.39615,1.14,0.249,6959,0.728,"VAV1, BLNK, PIK3R2, PLCG2, DAPP1, RAC2, VAV3, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, IFITM1, CD72, CD79A, RELA, CD19, CHP1, PPP3CA, LYN, PIK3R3, RAC1, MAPK1, NFATC1, PIK3R5, PIK3AP1, PIK3CB, NFKBIA, GSK3B, FOS, SYK, NFATC4, GRB2, CHP2, INPP5D, BCL10, CD22",0.603800652904264,0.137868620686963,FALSE +"transcriptomics","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.29926,0.873,0.66,4406,0.969,"DRD5, PTAFR, BDKRB2, ERBB2, P2RX4, PLCG2, GNA15, CACNA1D, ERBB3, GRIN1, PLCD1, ATP2A3, CALML3, NOS3, CAMK2G, ADORA2B, ADORA2A, CACNA1I, ADCY4, BDKRB1, RYR1, PTK2B, EGFR, ATP2B4, SLC8A2, GRIN2A, PLCG1, SPHK2, PHKG1, ADRB2, GRIN2D, CHP1, P2RX6, PPP3CA, EDNRA, TNNC1, GNAS, GNAQ, P2RX2, LTB4R2, HTR7",0.180456064458131,0.0136762229492347,FALSE +"transcriptomics","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.27818,0.803,0.804,6162,1,"TNNI3, CACNA1D, CACNG1, COX5B, CACNB3, CACNG4, CACNB2, COX6C, UQCR10, COX6B2, TNNT2, TNNC1, SLC9A1, UQCR11, UQCRB, UQCRHL, UQCRC1, CACNA1F, UQCRFS1, UQCRC2, COX6A1",0.0947439512515487,0,FALSE +"transcriptomics","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.37321,1.08,0.34,3535,0.763,"CDH3, NECTIN1, CDH1, CLDN8, ITGB2, CLDN9, CLDN7, CLDN4, F11R, ITGB8, CDH5, SDC1, ICOSLG, SDC4, CLDN18, ICAM3, CD6, GLG1, CLDN11, CD40, SELL, PTPRF, CLDN23, CD276, CLDN3",0.468521082957745,0.11747546204512,FALSE +"transcriptomics","Log2FC","KEGG_CELL_CYCLE",-0.36349,-1.24,0.163,15880,0.465,"ORC1, MCM4, PTTG2, CCNA2, ORC6, SMAD4, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, MCM3, ANAPC10, CDK6, CDC20, CDK1, SMC1A, CCNH, CCNB3, CDKN2C, CDC25A, TGFB1, ORC4, CCNB1, MCM6, PRKDC, TTK, CDC14A, CDKN2B, E2F2, BUB3, ORC2, CDC7, PTTG1, YWHAQ, HDAC2, SMC3, E2F5, ORC3, CDKN2A, E2F3, SMAD2, ANAPC13",0.787812395596042,0.332547047110046,FALSE +"transcriptomics","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.31904,0.923,0.581,4742,0.952,"CCR3, PRKCD, CCL22, STAT2, GRK7, VAV1, PIK3R2, FOXO3, GRK2, CX3CL1, RAC2, VAV3, CCL17, JAK3, CXCL10, IKBKB, MAPK3, CCL28, CCR2, ARRB1, VAV2, CCR7, ADCY5, PIK3CA, ADCY4, CXCL11, CXCL16, CCL5, PTK2B, STAT5B, RAP1A, CXCL9, CXCR2, STAT3, BRAF, ADCY6, RELA, TIAM1, PXN, GNB2, TIAM2, CCL26, CCL19, CXCL3, PRKCZ, CXCR6, WASL, LYN, PIK3R3, STAT1, CCR1",0.235823867609669,0.0213630516155257,FALSE +"transcriptomics","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.24297,0.703,0.912,6797,0.992,"CBLC, BCR, PIK3R2, IKBKB, MAPK3, PIK3CA, STAT5B, E2F1, CBLB, BRAF, CDKN1B, RELA, MECOM, RUNX1, BAD, PIK3R3, TGFB3, CRKL, STAT5A, TGFBR2, MAPK1, PIK3R5, PIK3CB, NFKBIA, CDKN1A, BCL2L1, GRB2, CTBP1, CCND1",0.0400051616715838,0.00348832784582135,FALSE +"transcriptomics","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.41491,1.2,0.185,4027,0.673,"BHLHE41, NR1D1, CSNK1E, BHLHE40, PER3",0.732828271596986,0.171984935776023,FALSE +"transcriptomics","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29489,0.843,0.711,7287,1,"PC, IDH2, ACO2, IDH3B, SDHD, OGDHL, MDH1, MDH2, OGDH, IDH3G, IDH1, SUCLG2, SDHA",0.148130399270234,0,FALSE +"transcriptomics","Log2FC","KEGG_COLORECTAL_CANCER",-0.17873,-0.649,0.991,14592,1,"KRAS, RAF1, LEF1, CASP9, BIRC5, AKT2, MAPK9, BCL2, MSH6, CASP3, MSH3, RHOA, APPL1, APC2, AKT3, SMAD4, PIK3R1, PIK3CG, MSH2, APC, TGFB1, TCF7, MAPK8, AXIN2, SMAD2",0.00392634551472468,0,FALSE +"transcriptomics","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.26321,0.77,0.815,6969,1,"BDKRB2, F3, BDKRB1, VWF, FGA, FGG, CFB, PROC, C3, PLAU, CD59, SERPINA5, C2, PLAT, SERPINA1, C9, C1R, CFI, F8, CD55, C4A, SERPINF2, F12, FGB",0.0888423912600234,0,FALSE +"transcriptomics","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.22246,-0.76,0.82,15262,1,"BHMT, ADI1, MTR, CDO1, GOT2, SRM, LDHB, MAT2A, AMD1, SMS, MTAP, TRDMT1",0.0861861476162833,0,FALSE +"transcriptomics","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33412,0.966,0.488,5572,0.865,"CCR3, IFNL3, IFNL1, CSF1R, CCL22, TNFSF13, IFNL2, IL1RAP, CRLF2, TNFRSF21, PDGFA, IL9R, BMP7, CX3CL1, TNFRSF18, CCL17, IL4R, VEGFB, CXCL10, LTBR, CCL28, CCR2, IFNLR1, EPOR, IFNB1, PDGFB, BMP2, CCR7, FLT3LG, MET, CXCL11, CXCL16, CCL5, TNFRSF25, EGFR, CTF1, ACVR1B, IL18, CD40, IL12B, CXCL9, TNFSF10, CXCR2, TNFRSF14, CLCF1, IL7R, EPO, CCL26, IL20RB, IL6R, IL6, NGFR, CCL19, CXCL3, IL20RA, TNFSF18, CXCR6, VEGFA, CSF2, TNFRSF12A, IL15RA, CCR1, LTB, IL12A, IL1R2, PRLR, TGFB3, CSF1, GH2, OSMR, INHBB, IL1A, VEGFC, EDAR, IFNGR1, TGFBR2, CXCL6, IL17RA, CSF2RB",0.311580177997289,0.0629838925351858,FALSE +"transcriptomics","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.36654,1.06,0.328,3908,0.767,"CASP1, MAVS, RIPK3, IRF3, CXCL10, IKBKB, IFNB1, CCL5, DDX58, IL18, PYCARD, RELA, IKBKE, IL6",0.484126156288321,0.115204636051019,FALSE +"transcriptomics","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",0.30112,0.866,0.689,4386,0.977,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ADCY5, ADCY4, ITGA3, CACNB2, DAG1, ITGA2B, ADCY6, TNNT2, TNNC1, GNAS, ITGA2",0.161780778092374,0.0101054362812269,FALSE +"transcriptomics","Log2FC","KEGG_DNA_REPLICATION",-0.44719,-1.71,0.0108,15778,0.18,"DNA2, RFC2, MCM4, RFC5, MCM3, RNASEH1, PRIM1, MCM6, RNASEH2B, PRIM2, POLE3, RFC1, RPA2, POLA1",1.96657624451305,0.744727494896694,TRUE +"transcriptomics","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.4409,1.28,0.127,5751,0.78,"ETV7, ETS2, MAPK3, ETV6, EGFR, NOTCH3, PIWIL2, NOTCH1, MAPK1, SPIRE1, SPIRE2",0.896196279044043,0.10790539730952,FALSE +"transcriptomics","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.47037,1.35,0.0766,3662,0.771,"ADH7, ALDH3B2, GSTK1, CYP2E1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, FMO4, MGST2, CYP2D6, UGT2B17, MGST3",1.1157712303674,0.112945621949043,FALSE +"transcriptomics","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.40437,1.17,0.239,3623,0.723,"XDH, TYMP, NAT1, UCKL1, CES2, UPP1, TK1, CDA, UGT2B17, TPMT, GUSB, ITPA",0.621602099051862,0.140861702705469,FALSE +"transcriptomics","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.39479,1.14,0.246,4629,0.728,"CHAD, LAMA3, ITGB6, LAMB3, ITGB8, SDC1, SDC4, CD47, TNC, LAMC2, GP6, ITGB4, CD44, AGRN, THBS3, VWF, ITGA3, DAG1, THBS1, ITGA2B, COL1A1, LAMA5, LAMB1, ITGA2, COL5A1, HSPG2",0.609064892896621,0.137868620686963,FALSE +"transcriptomics","Log2FC","KEGG_ENDOCYTOSIS",0.41396,1.21,0.193,5701,0.676,"EPN3, CHMP4B, CBLC, PSD4, CSF1R, ITCH, TRAF6, RAB11FIP4, CHMP2B, GRK7, FGFR2, RAB22A, PLD1, ARFGAP1, CHMP2A, GRK2, RAB5B, ARAP1, ERBB3, TFRC, ACAP1, EHD2, PLD2, SMURF1, VPS37C, ARRB1, CHMP5, PRKCI, CHMP3, RAB11FIP1, MET, MVB12A, SH3GLB2, IGF1R, CHMP6, VPS28, ARAP2, PARD6B, EGFR, EPN1, ARFGAP3, VPS37B, FGFR3, LDLRAP1, CXCR2, ARFGAP2, CBLB, EPS15, AP2M1, ADRB2, SRC, HSPA1B, CHMP4C, RAB11FIP5, AGAP1, ACAP2, PRKCZ, AP2A1, NEDD4L, ARAP3, PIP5K1C, STAMBP, CHMP1B, LDLR, ASAP2, HSPA2, IQSEC1, DNM2, RAB11B, RAB31, ARF6, RAB5C, VPS25, STAM2",0.714442690992226,0.170053304058364,FALSE +"transcriptomics","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.26466,0.768,0.846,3392,1,"CDH1, ERBB2, PIK3R2, FOXO3, MAPK3, PIK3CA, EGFR, BRAF, TCF7L1",0.0726296369609765,0,FALSE +"transcriptomics","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.38362,1.1,0.294,6354,0.738,"MAPK13, PLCG2, F11R, ATP6V1C2, ATP6V0D2, ATP6V1B1, ATP6V1F, IKBKB, MET, CCL5, EGFR, ATP6AP1, CXCR2, PLCG1, RELA, SRC, MAPK11, NOD1, ADAM10, TCIRG1, LYN, ATP6V1G1, ATP6V0A4, RAC1, PAK1, MAPK10, ATP6V1C1, NFKBIA, TJP1, ATP6V1E1, IGSF5",0.531652669587843,0.131943638176958,FALSE +"transcriptomics","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.39525,1.16,0.214,5894,0.724,"GAB1, PAK6, CBLC, ERBB2, PIK3R2, PLCG2, ERBB3, CAMK2G, MAPK3, RPS6KB2, PIK3CA, NCK2, EGFR, STAT5B, BTC, CBLB, BRAF, PLCG1, CDKN1B, SRC, TGFA, PAK2, AREG, BAD, PIK3R3, NCK1, CRKL, STAT5A, PAK1, PAK4, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB",0.669586226650809,0.140261433802853,FALSE +"transcriptomics","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.38786,1.13,0.257,3971,0.705,"PLA2G12A, PLD1, PLA2G6, PLA2G4B, PLD2, LPCAT2, PLA2G10, PLA2G4E, PLPP3, LPCAT4, PLA2G2C",0.590066876668705,0.151810883008601,FALSE +"transcriptomics","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.38078,1.1,0.304,3627,0.738,"ADH7, ACAA1, CPT1B, GCDH, CYP4A22, ACSL1, CPT2, CPT1C, ACADS, EHHADH, ACOX1, ACSL3",0.517126416391246,0.131943638176958,FALSE +"transcriptomics","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.33886,0.979,0.494,2596,0.867,"PRKCD, PLA2G12A, VAV1, MAPK13, PIK3R2, PLCG2, RAC2, VAV3, PLA2G6, PLA2G4B, MAPK3, VAV2, PIK3CA, PLA2G10, PLA2G4E",0.306273051076353,0.0619809025237897,FALSE +"transcriptomics","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.40295,1.16,0.224,5894,0.724,"PRKCD, VAV1, PLD1, PIK3R2, PLCG2, RAC2, VAV3, LIMK2, PLA2G6, PLA2G4B, PLA2G4F, PLD2, MAPK3, RPS6KB2, VAV2, MARCKS, GSN, PIK3CA, PLA2G4E, PLCG1, PLPP3, SPHK2, WASL, LYN, PIK3R3, PIP5K1C, SPHK1, LIMK1, CRKL, SCIN, ASAP2, MYO10, DNM2, RAC1, PAK1, ARF6, MAPK1, PIK3R5, PIK3CB",0.649751981665837,0.140261433802853,FALSE +"transcriptomics","Log2FC","KEGG_FOCAL_ADHESION",0.30588,0.889,0.64,6359,0.957,"PAK6, CHAD, ERBB2, LAMA3, VAV1, ITGB6, PDGFA, PIK3R2, LAMB3, ITGB8, RAC2, VAV3, VEGFB, TNC, LAMC2, ITGB4, MAPK3, PPP1CA, VAV2, PDGFB, PIK3CA, PPP1CB, MET, IGF1R, THBS3, VWF, PDGFD, ITGA3, EGFR, RAP1A, THBS1, ITGA2B, BRAF, CAV2, PXN, COL1A1, SRC, CAV1, MYL9, ARHGAP35, PAK2, LAMA5, BAD, PGF, LAMB1, ITGA2, COL5A1, VEGFA, RASGRF1, PIK3R3, PIP5K1C, CRKL, MYL7, ARHGAP5, VEGFC, RAC1, PAK1, BCAR1, PAK4, MAPK1, MAPK10, PIK3R5, PIK3CB, PTEN, COL1A2, ITGA5, TLN2, GSK3B, COL6A1, DIAPH1, ITGA4, CAPN2",0.193820026016113,0.0190880622231565,FALSE +"transcriptomics","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.42522,1.23,0.169,5764,0.725,"ALPP, QDPR, SPR, FPGS",0.772113295386326,0.139661993429006,FALSE +"transcriptomics","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.5816,1.69,0.0111,3752,0.342,"ALDOC, PFKFB2, HK2, MPI, GMPPA, FBP1, GMPPB, PFKL, FBP2, MTMR1, FPGT, HK1, PFKFB4, ALDOA",1.95467702121334,0.465973893943865,FALSE +"transcriptomics","Log2FC","KEGG_GALACTOSE_METABOLISM",0.52612,1.52,0.0308,3636,0.462,"HK2, GCK, GAA, PGM1, PFKL, B4GALT1, GALT, GANC, HK1, B4GALT2, GLB1, GALE",1.51144928349956,0.335358024443874,FALSE +"transcriptomics","Log2FC","KEGG_GAP_JUNCTION",-0.17017,-0.601,1,15556,1,"ADRB1, TUBB3, ITPR2, MAP2K5, ADCY7, PRKX, TUBA1B, TUBB, GNAI1, ITPR1, TUBAL3, PRKACB, CDK1, PLCB4, PDGFRA, TUBA1A, NRAS, TUBB4A, TUBB2B, TUBB2A",0,0,FALSE +"transcriptomics","Log2FC","KEGG_GLIOMA",0.26293,0.766,0.846,3686,0.994,"PDGFA, PIK3R2, PLCG2, CALML3, CAMK2G, MAPK3, PDGFB, PIK3CA, IGF1R, EGFR, E2F1, BRAF, PLCG1, TGFA",0.0726296369609765,0.00261361560268669,FALSE +"transcriptomics","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.33643,0.973,0.488,4600,0.865,"GSTK1, GGT7, GSTT2, GSTO2, GSS, IDH2, GSTZ1, GSTA3, OPLAH, MGST2, GGT6, GPX1, MGST3, ANPEP, G6PD, GPX3",0.311580177997289,0.0629838925351858,FALSE +"transcriptomics","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.17981,0.518,0.998,5968,0.997,"DGKA, LIPG, DGAT1, MGLL, TKFC, PLPP3, CEL, DGKH, AGPAT2, PNPLA3, DGKI, AWAT2, MBOAT1, DGKE",0.000869458712628891,0.00130484168834428,FALSE +"transcriptomics","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.36747,1.06,0.367,5053,0.767,"PISD, CDS1, PLA2G12A, CHKB, DGKA, PLD1, PLA2G6, PLA2G4B, PLD2, PCYT2, CHKA, LPCAT2, ETNK2, CDS2, PLA2G10, PLA2G4E, PLPP3, MBOAT7, LPCAT4, PLA2G2C, DGKH, AGPAT2, PGS1, LPCAT3, LYPLA2, ACHE, PCYT1A, DGKI",0.435333935747911,0.115204636051019,FALSE +"transcriptomics","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.31093,0.9,0.625,6983,0.966,"AGXT, GCAT, AOC2, GATM, SARDH, SHMT1, MAOA, AMT, GAMT, CTH, SDS, GNMT, AOC3, ALAS2, SRR",0.204119982655925,0.0150228735845067,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.4334,1.26,0.141,1880,0.765,"LDHC, ADH7, ACSS2, ALDH3B2, ALDOC, HK2, ALDH1A3, GCK, ALDH3B1, FBP1, PGM1, GALM, PFKL",0.85078088734462,0.116338564846382,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.43624,1.26,0.152,4160,0.765,"B4GALT7, CHPF, CHST12, XYLT2, CHST14, XYLT1, CHPF2, CHST11, CHST15",0.818156412055227,0.116338564846382,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.45434,1.33,0.0999,3529,0.806,"B4GALT7, EXT1, HS3ST1, XYLT2, HS6ST1, NDST1, HS6ST2, XYLT1",1.00043451177402,0.0936649581949093,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66703,1.93,0.00221,3600,0.281,"B3GNT7, CHST6, B4GALT4, B4GALT1, B3GNT2, CHST4, ST3GAL1, B4GALT2",2.65560772631489,0.55129368009492,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.5591,1.62,0.0148,4196,0.343,"HGSNAT, NAGLU, HPSE, HYAL4, IDS, GALNS, HYAL2, GUSB, GLB1, HEXB",1.82973828460504,0.464705879957229,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.42593,1.24,0.16,6306,0.758,"ST6GALNAC5, B3GALT4, SLC33A1, ST3GAL1, GLB1, HEXB, ST6GALNAC6, ST6GALNAC4, HEXA, ST8SIA1",0.795880017344075,0.120330794367946,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.58271,1.68,0.0135,4276,0.305,"FUT2, FUT1, NAGA, B3GALNT1, ST3GAL1, GBGT1, A4GALT, HEXB, B3GALT5",1.86966623150499,0.515700160653214,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.59777,1.73,0.00448,3600,0.327,"B3GNT3, ABO, FUT3, FUT2, B4GALT4, B3GNT5, B3GNT4, B4GALT1, FUT1, B3GNT2, ST3GAL4, B4GALT2",2.34872198600186,0.485452247339714,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.50004,1.45,0.0565,3611,0.59,"PIGT, PIGU, GPAA1, PIGZ, PIGV, PIGQ, PIGL, PIGX, PIGS",1.24795155218056,0.229147988357856,FALSE +"transcriptomics","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.50461,-1.71,0.0427,16224,0.18,"HYI, MTHFD2L, MTHFD2, ACO1, CS, MTHFD1L, HAO2",1.36957212497498,0.744727494896694,TRUE +"transcriptomics","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.34964,1.01,0.418,2596,0.814,"PRKCD, PLA2G12A, MAPK13, PLD1, CACNA1D, PLA2G6, CALML3, PLA2G4B, MAP3K4, PLD2, CAMK2G, MAPK3, MAP3K1, ADCY5, CGA, ADCY4, MMP14, PTK2B, PLA2G10, EGFR, PLA2G4E",0.378823718224965,0.0893755951107988,FALSE +"transcriptomics","Log2FC","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.20626,-0.725,0.907,3907,1,"IL6, IL1A, KLRC1, KIR2DL1, IL1B, KIR2DL3, KIR3DL2, CD86, FAS, CD80, IFNG, CD28, TNF, KLRD1, GZMB, FASLG, IL2, PRF1",0.0423927129399047,0,FALSE +"transcriptomics","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.36379,1.05,0.356,2621,0.766,"WNT3A, WNT9A, WNT7B, BMP7, WNT7A, WNT4, BMP2, CSNK1E, WNT10A, CSNK1A1, GLI3",0.448550002027125,0.115771230367396,FALSE +"transcriptomics","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.38485,1.1,0.309,6109,0.738,"CSF1R, IL9R, IL4R, TFRC, EPOR, FLT3LG, CD44, ITGA3, CD9, ITGA2B, CD19, IL7R, EPO, IL6R, IL6, ANPEP, CD59, ITGA2, CSF2, CD4, IL1R2, CSF1, IL1A, IL1R1, CD1D, CD55, ITGA5",0.510041520575165,0.131943638176958,FALSE +"transcriptomics","Log2FC","KEGG_HISTIDINE_METABOLISM",0.35152,1.02,0.42,1584,0.793,"ALDH3B2, HEMK1, HAL, ALDH1A3, ALDH3B1",0.3767507096021,0.100726812682396,FALSE +"transcriptomics","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",0.23381,0.681,0.927,764,0.998,"POLD4, SEM1",0.0329202658555029,0.000869458712628891,FALSE +"transcriptomics","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.17121,-0.59,0.979,16664,0.989,"ITPR1, NDUFS4, BBC3, AP2S1, SOD1, COX6B1, COX7A2, DCTN4, AP2A2, PLCB4, ATP5F1C, NDUFA9, VDAC2, POLR2E, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, HDAC2, HIP1, TBPL1, TBP, UCP1, ATP5F1A, POLR2D, BDNF, NDUFS5, TFAM, GRIN2B",0.00921730819686218,0.0048037084028206,FALSE +"transcriptomics","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.30969,0.896,0.624,4437,0.967,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ITGA3, CACNB2, DAG1, ITGA2B, PRKAA1, ACE, TNNT2, IL6, TNNC1, ITGA2, PRKAG2",0.204815410317576,0.0145735259169983,FALSE +"transcriptomics","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.30094,0.881,0.667,6116,0.959,"PLCG2, INPP4B, PLCD1, INPP4A, ALDH6A1, PIK3CA, PIP4K2C, PLCG1, PIK3C2G, PIK3C2B, INPP5K, IMPA2, PIP5K1C, INPPL1, INPP5J, ISYNA1, PIK3CB, PTEN, PLCB3, IPMK",0.175874166083451,0.0181813928293364,FALSE +"transcriptomics","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.32542,0.945,0.526,6911,0.907,"CBLC, PPP1R3D, HK2, PTPN1, PIK3R2, GYS1, CALML3, SOCS1, MKNK1, GCK, IKBKB, MAPK3, RPS6KB2, FBP1, INSR, PPP1CA, SH2B2, PIK3CA, PPP1CB, PRKCI, TSC1, FBP2, IRS2, PTPRF, CBLB, BRAF, PRKAA1, PHKG1, HK1, FOXO1, PRKCZ, BAD, PRKAG2, INPP5K, EXOC7, PIK3R3, FASN, PYGL, CALML6, CRKL, PRKAB2, PRKACA, RHEB, PPP1R3B, MAPK1, FLOT2, MAPK10, PIK3R5, IRS1, PIK3CB, PRKAR1B, GSK3B, PHKG2, TRIP10, GRB2, INPP5D, PYGB, PRKAG1, TSC2, RPTOR",0.279014255846261,0.0423927129399047,FALSE +"transcriptomics","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.3125,0.906,0.613,3908,0.97,"TNFSF13, ICOSLG, LTBR, CCL28, CD40, PIGR, IL6",0.212539525481585,0.0132282657337552,FALSE +"transcriptomics","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.33678,0.978,0.487,5894,0.86,"IFNL3, IFNL1, CBLC, STAT2, IFNL2, CRLF2, PIK3R2, IL9R, IRF9, JAK3, IL4R, SOCS1, CISH, IFNLR1, EPOR, PTPN6, IFNB1, PIK3CA, TYK2, EP300, STAT6, CTF1, STAT5B, IL12B, CBLB, STAT3, CLCF1, IL7R, EPO, IL20RB, IL6R, IL6, PIAS3, IL20RA, PIM1, CSF2, PIK3R3, SPRY1, IL15RA, STAT1, IL12A, PRLR, GH2, STAT5A, OSMR, IFNGR1, JAK1, CSF2RB, STAM2, PIK3R5, PIK3CB",0.312471038785366,0.0655015487564323,FALSE +"transcriptomics","Log2FC","KEGG_LEISHMANIA_INFECTION",0.42556,1.23,0.169,6358,0.725,"TRAF6, ITGB2, NCF4, MAPK13, MAPK3, PTPN6, MYD88, IL12B, TAB1, RELA, MAPK11, C3, TLR2, IRAK4, STAT1, IL12A, TGFB3, IL1A, IFNGR1, JAK1, TAB2, MAPK1, NFKBIA, FOS, ITGA4",0.772113295386326,0.139661993429006,FALSE +"transcriptomics","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.41873,1.21,0.197,3793,0.676,"CTNND1, CLDN8, ITGB2, MMP9, CLDN9, VAV1, NCF4, CLDN7, MAPK13, PIK3R2, PLCG2, CLDN4, F11R, CDH5, RAC2, VAV3, VAV2, CLDN18, PIK3CA, RASSF5, PTK2B, RAP1A, CLDN11, RAPGEF3, PLCG1, SIPA1, PXN, CLDN23, CLDN3, MYL9, MAPK11, ARHGAP35",0.705533773838407,0.170053304058364,FALSE +"transcriptomics","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.42081,-1.51,0.0531,15341,0.332,"ALDH3A2, HADHA, YOD1, ALDH1B1, ALDH7A1, ALDH9A1",1.27490547891853,0.478861916295964,FALSE +"transcriptomics","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",0.40266,1.17,0.225,2596,0.723,"PLA2G12A, CYP2E1, PLA2G6, PLA2G4B, CYP2J2, PLA2G10, PLA2G4E",0.647817481888638,0.140861702705469,FALSE +"transcriptomics","Log2FC","KEGG_LONG_TERM_DEPRESSION",0.24312,0.697,0.91,6599,0.99,"PLA2G12A, GNAO1, PLA2G6, PLA2G4B, MAPK3, IGF1R, RYR1, PLA2G10, PLA2G4E, BRAF, PLA2G2C, GNAS, GNAQ, LYN, ITPR3, MAPK1, PLCB3, PPP2R1A, GUCY1A1, NOS1, PLA2G2F, GUCY1B1, GNA12",0.0409586076789064,0.00436480540245009,FALSE +"transcriptomics","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.23447,0.677,0.924,5774,0.994,"GRIN1, CALML3, CAMK2G, MAPK3, PPP1CA, PPP1CB, EP300, RAP1A, RAPGEF3, GRIN2A, BRAF, GRIN2D, CHP1, PPP3CA, GNAQ, RPS6KA2, CALML6, ITPR3, PRKACA, MAPK1, RPS6KA1",0.0343280287798933,0.00261361560268669,FALSE +"transcriptomics","Log2FC","KEGG_LYSINE_DEGRADATION",0.22598,0.655,0.957,2472,0.983,"BBOX1, KMT5B, KMT5C, GCDH, AASDH, EHHADH",0.0190880622231565,0.00744648216786438,FALSE +"transcriptomics","Log2FC","KEGG_LYSOSOME",0.52683,1.52,0.0362,5277,0.462,"CTSH, GM2A, CTSA, CTSV, HGSNAT, SLC11A1, NAGLU, GGA2, CTSD, ARSA, ATP6V0D2, LIPA, DNASE2, ABCB9, SUMF1, GAA, MANBA, NPC1, NAGA, ACP5, PSAP, IDS, GNPTG, NPC2, AP1M2, GALNS, CTSS, LAPTM4A, NAPSA, AP1B1, AP3M2, GGA1, LGMN, NEU1, TPP1, ATP6AP1, PSAPL1, ASAH1, LAMP3, CD68, CTSB, LAMP1, CLN5, GUSB, GLB1, GGA3, AP3S2, LAMP2, FUCA1, NAGPA, SCARB2, CTSE, HEXB, PPT1, AP1S1, TCIRG1, MAN2B1, CD63, SLC11A2, MFSD8, ABCA2, CTSZ, SORT1, AP1S3, ATP6V0A4, ENTPD4, GBA",1.44129142946683,0.335358024443874,FALSE +"transcriptomics","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",0.26798,0.771,0.843,5856,1,"NTF4, PLA2G12A, TRAF6, FGF11, FGFR2, MAPK13, PDGFA, CACNA1D, RAC2, CACNG1, PLA2G6, PLA2G4B, MAP3K4, MKNK1, DUSP9, CACNB3, HSPB1, CACNG4, IKBKB, MAPK3, ARRB1, MAP4K1, MAP3K1, PDGFB, CACNA1I, FGF1, DUSP3, MAPK8IP2, MAX, NTRK2, PLA2G10, EGFR, CACNB2, PLA2G4E, MAP3K11, MAPKAPK3, RAP1A, JUND, ECSIT, MAP3K6, TAB1, LAMTOR3, FGFR3, MAP3K13, TAOK3, BRAF, DUSP10, RELA, STK3, DUSP14, CHP1, HSPA1B, MAPK11, PPP3CA, PAK2, PLA2G2C, MECOM, MAP3K8, GADD45B, RASGRF1, FGF12, MAP4K2, MAP3K5, RPS6KA2, IL1R2, RASA1, RPS6KA4, MAPKAPK2, NF1, STK4, TGFB3, CRKL, PPM1A, HSPA2, NGF, PRKACA, IL1A, RAC1, PAK1, MAP4K3, TGFBR2, RRAS, TAB2, MAPK1, DUSP8, MAP2K7, NLK, GADD45A, RPS6KA1, MAPK10, MAPK8IP3, CACNA1F",0.0741724253752577,0,FALSE +"transcriptomics","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26478,0.766,0.83,1432,0.994,"HES1, GCK",0.0809219076239261,0.00261361560268669,FALSE +"transcriptomics","Log2FC","KEGG_MELANOGENESIS",0.36219,1.05,0.373,6175,0.766,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, GNAO1, CALML3, WNT4, DVL3, CAMK2G, MAPK3, ADCY5, WNT10A, ADCY4, EP300, ADCY6, TCF7L1, FZD4, CREB3L4, DVL2, WNT11, GNAS, GNAQ, CALML6, CREB3L3, MITF, PRKACA, ASIP, CREB3L2, MAPK1, EDN1, CREB3L1, WNT5A, PLCB3, FZD6, GSK3B",0.428291168191312,0.115771230367396,FALSE +"transcriptomics","Log2FC","KEGG_MELANOMA",-0.26432,-0.868,0.592,16564,0.965,"PIK3R1, PIK3CG, FGF20, CDK6, FGF21, FGF2, PDGFRA, E2F2, NRAS, IGF1, FGF9, FGF4, CDKN2A, FGF5, FGFR1, E2F3, FGF19, FGF3",0.22767829327708,0.0154726866562074,FALSE +"transcriptomics","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.45636,1.31,0.122,3662,0.806,"ADH7, ALDH3B2, GSTK1, DHDH, CYP2E1, CYP1B1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, MGST2, UGT2B17, MGST3",0.913640169325252,0.0936649581949093,FALSE +"transcriptomics","Log2FC","KEGG_MISMATCH_REPAIR",-0.32549,-1.14,0.257,15319,0.598,"MSH6, RFC3, MSH3, RFC2, RFC5, EXO1, MSH2, RFC1, RPA2",0.590066876668705,0.223298816011589,FALSE +"transcriptomics","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.35512,1.04,0.369,6050,0.764,"PIK3R2, VEGFB, MAPK3, RPS6KB2, PIK3CA, TSC1, CAB39, RICTOR, BRAF, PRKAA1, PGF, VEGFA, PIK3R3, HIF1A, RPS6KA2, DDIT4, VEGFC, RHEB, MAPK1, RPS6KA1, PIK3R5, PIK3CB, ULK1",0.43297363384094,0.11690664142431,FALSE +"transcriptomics","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.2602,0.75,0.849,6624,0.987,"ITGB2, VAV1, PIK3R2, PLCG2, RAC2, VAV3, RAET1L, MAPK3, PTPN6, VAV2, IFNB1, PIK3CA, SH3BP2, PTK2B, TNFSF10, BRAF, PLCG1, CHP1, PPP3CA, LCK, CSF2, PIK3R3, ULBP2, RAC1, IFNGR1, PAK1, BID, MAPK1, NFATC1, PIK3R5, PIK3CB, SYK, NFATC4, HCST, GRB2, CHP2",0.0710923097560473,0.00568284733036327,FALSE +"transcriptomics","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.21335,0.619,0.971,5100,0.991,"DRD5, P2RY2, VIPR2, PTAFR, BDKRB2, P2RY6, P2RX4, LPAR2, VIPR1, S1PR4, THRB, GRIN1, NPBWR1, ADORA1, ADORA2B, ADORA2A, GIPR, S1PR2, GALR3, CGA, BDKRB1, GHSR, GABRP, F2RL3, GRIN2A, OPRL1, CHRNB4, MLNR, S1PR5, ADRB2, GRIN2D, P2RX6, EDNRA, F2RL1, MC3R, P2RX2, LTB4R2, HTR7, CHRNB1, ADRA2A, GRIN3B, GRM4, LTB4R, PRLR, ADRA2B, GH2",0.0127807700919951,0.00392634551472468,FALSE +"transcriptomics","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.33316,0.966,0.512,5975,0.865,"GAB1, NTF4, PRKCD, TRAF6, MAPK13, PIK3R2, PLCG2, FOXO3, CALML3, ARHGDIB, IKBKB, CAMK2G, MAPK3, MAP3K1, SH2B2, PIK3CA, NTRK2, RAP1A, IRS2, TP73, BRAF, PLCG1, YWHAB, RELA, MAPK11, NGFR, IRAK4, BAD, YWHAZ, MAP3K5, PIK3R3, YWHAH, RPS6KA2, SORT1, CALML6, RPS6KA4, MAPKAPK2, CRKL, NGF, RAC1, BAX, MAPK1, MAP2K7, RPS6KA1, MAPK10, PIK3R5, IRS1, PIK3CB, NFKBIA",0.290730039024169,0.0629838925351858,FALSE +"transcriptomics","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.264,0.761,0.818,4274,0.994,"QPRT, NMRK1, NADSYN1, NADK, NT5C1B",0.087246696328677,0.00261361560268669,FALSE +"transcriptomics","Log2FC","KEGG_NITROGEN_METABOLISM",0.31831,0.925,0.553,2116,0.957,"GLUL, HAL, GLS2, CA9",0.257274868695302,0.0190880622231565,FALSE +"transcriptomics","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.34339,0.985,0.463,4477,0.859,"CASP1, TRAF6, MAPK13, TAB3, IKBKB, MAPK3, TRIP6, CCL5, IL18, PYCARD, TAB1, RELA, CARD6, MAPK11, IL6, NOD1, NOD2, PSTPIP1, NLRP1",0.334419008982047,0.0660068361687577,FALSE +"transcriptomics","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.55072,-2.02,0,17605,0.331,"RAD50, PRKDC, NHEJ1, XRCC5",Inf,0.480172006224281,FALSE +"transcriptomics","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.34338,0.992,0.454,3686,0.848,"ERBB2, RXRA, PIK3R2, PLCG2, FOXO3, MAPK3, PIK3CA, RASSF5, RXRB, EGFR, E2F1, BRAF, PLCG1, TGFA",0.342944147142896,0.0716041477432862,FALSE +"transcriptomics","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.39588,1.15,0.237,5482,0.725,"DTX4, HES1, DVL3, DTX3L, JAG1, DTX2, RFNG, EP300, DLL1, LFNG, NOTCH3, APH1A, MFNG, DVL2, JAG2, NUMB, NOTCH1, KAT2A, HES5",0.625251653989896,0.139661993429006,FALSE +"transcriptomics","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.30853,-1.03,0.337,15978,0.693,"RFC2, XPC, RFC5, GTF2H1, XPA, GTF2H3, ERCC3, CUL4A, ERCC8, CCNH, ERCC1, POLE3, RFC1, RPA2, GTF2H2",0.472370099128661,0.159266765388193,FALSE +"transcriptomics","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.39086,1.13,0.248,3600,0.705,"MAN1B1, RPN2, ALG12, ALG3, DPM1, MOGS, MGAT4A, MGAT1, B4GALT1, MGAT5B, STT3A, ALG2, B4GALT2",0.605548319173784,0.151810883008601,FALSE +"transcriptomics","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",0.24959,0.721,0.902,7709,1,"OR4C6, OR10H2, OR2J3, OR11H4, OR8A1, OR2A12, OR2D3, GUCY2D, CALML3, OR8B8, CAMK2G, CLCA2, OR1G1, OR2A7, OR13H1, OR1I1, OR13D1, CNGB1, OR1F1, OR8G5, OR8G1, OR10A3, OR1M1, OR6Q1, OR1K1, OR5P2, OR10H1, OR10A4, OR4D2, OR2A2, CNGA4, OR52B4, CALML6, OR2D2, OR2B2, OR1J1, OR6B1, PRKACA, OR2A14, GUCA1B, OR52K1, OR9A2, OR10A6, OR4L1, OR10AD1, OR2S2, OR10S1, OR10A2, OR2A5, OR10K2, OR10A5, OR8S1, OR4X2, OR5P3, ADCY3, OR6C70, OR8D2, OR8B4, OR2L2, CAMK2D, OR10G3, PRKG2, OR4K1, PRKACG, GRK3, OR8D1, OR52I1, OR6A2",0.0447934624580583,0,FALSE +"transcriptomics","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.44426,-1.49,0.0698,14974,0.282,"DHFR, SHMT2, MTHFS, MTR, MTHFD2L, GART, MTHFD2, MTHFD1L, TYMS, ATIC",1.15614457737684,0.549750891680639,FALSE +"transcriptomics","Log2FC","KEGG_OOCYTE_MEIOSIS",-0.25168,-0.876,0.643,15742,0.981,"ITPR2, PPP2R5D, PPP3CC, ADCY7, PPP2R5C, PRKX, RPS6KA3, PTTG2, PPP2CB, PPP2R1B, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, ITPR1, ANAPC10, FBXO5, CDC20, PRKACB, PPP3R1, CDK1, SMC1A, CALM2, CCNB1, FBXO43, CPEB1, AR, PTTG1, YWHAQ, SGO1, SMC3, IGF1, PPP1CC, ANAPC13",0.191789027075778,0.0083309926200515,FALSE +"transcriptomics","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",0.61199,1.76,0.00562,5940,0.349,"MANBA, NEU1, ENGASE, MAN2B2, MAN2C1, GLB1, FUCA1, HEXB, MAN2B1, GBA, HEXA, AGA",2.25026368443094,0.45717457304082,FALSE +"transcriptomics","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",0.23049,0.668,0.939,6376,0.987,"NDUFV1, LHPP, ATP6V1C2, COX5B, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP5F1E, NDUFB7, NDUFS8, NDUFA3, NDUFV2, ATP6AP1, COX6C, UQCR10, COX6B2, SDHD, UQCR11, TCIRG1, NDUFB4, NDUFAB1, ATP6V1G1, UQCRB, ATP6V0A4, NDUFA6, UQCRHL, NDUFA5, UQCRC1, NDUFB5, COX15, ATP5MG, UQCRFS1, ATP6V1C1, UQCRC2, COX6A1, ATP6V1E1, NDUFA2, COX17, ATP5PD",0.0273344077338891,0.00568284733036327,FALSE +"transcriptomics","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.49419,1.42,0.0645,4056,0.649,"GALNT12, GALNT3, GALNT7, GALNT6, B4GALT5, GCNT1, ST6GALNAC1, GCNT3, C1GALT1, GALNT15, ST3GAL1, GALNT11, GALNT9, B3GNT6",1.19044028536473,0.187755303199631,FALSE +"transcriptomics","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.1914,0.56,0.989,5981,1,"TP53AIP1, CCNG2, CD82, SERPINB5, SFN, THBS1, TP73, ATR, PERP, SHISA5, EI24, GADD45B, ZMAT3, CCNE1, SIAH1, PIDD1, BID, IGFBP3, BAX, CHEK2, GADD45A, PTEN",0.0048037084028206,0,FALSE +"transcriptomics","Log2FC","KEGG_PANCREATIC_CANCER",0.34675,1,0.44,5894,0.834,"ERBB2, PLD1, PIK3R2, RALB, RAC2, VEGFB, IKBKB, MAPK3, RALGDS, PIK3CA, EGFR, E2F1, RALBP1, STAT3, BRAF, RELA, TGFA, BAD, PGF, VEGFA, PIK3R3, STAT1, TGFB3, RALA, VEGFC, RAC1, JAK1, TGFBR2, MAPK1, MAPK10, PIK3R5, PIK3CB",0.356547323513813,0.0788339493622613,FALSE +"transcriptomics","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.31788,0.92,0.571,8542,0.95,"PANK2, PPCS, ENPP1, COASY, UPB1, PPCDC, BCAT2, DPYD, VNN2",0.243363891754152,0.0222763947111523,FALSE +"transcriptomics","Log2FC","KEGG_PARKINSONS_DISEASE",-0.18037,-0.604,1,17631,1,"UBE2J2, ATP5F1C, NDUFA9, VDAC2, LRRK2, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, UCHL1, ATP5F1A, SLC18A2, PARK7, NDUFS5",0,0,FALSE +"transcriptomics","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.30571,-1.09,0.283,18248,0.576,"YWHAQ, TUBA1A, NCL, ROCK2, TUBB4A, ARHGEF2, TUBB2B, TUBB2A",0.54821356447571,0.239577516576788,FALSE +"transcriptomics","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.2849,0.828,0.749,5981,0.999,"WNT3A, WNT9A, CBLC, CSF1R, WNT7B, CDH1, ERBB2, FZD10, LAMA3, TRAF6, FGF11, MMP9, RXRA, BCR, FGFR2, TRAF4, PLD1, PDGFA, PIK3R2, PLCG2, RALB, LAMB3, EGLN3, WNT7A, RAC2, WNT4, VEGFB, LAMC2, DVL3, IKBKB, MAPK3, RALGDS, PML, PDGFB, RARA, BMP2, FLT3LG, PIK3CA, JUP, RASSF5, WNT10A, FADD, RXRB, MET, IGF1R, FGF1, MAX, ITGA3, EP300, EGFR, GLI3, STAT5B, E2F1, DAPK1, RALBP1, FGFR3, ITGA2B, PPARG, CBLB, ARNT2, STAT3, BRAF, PLCG1, CDKN1B, RELA, TCF7L1, FZD4, TGFA, FOXO1, IL6, DVL2, MECOM, LAMA5, WNT11, RUNX1, BAD, PGF, PIAS3, LAMB1, EPAS1, ITGA2, VEGFA, FGF12, DAPK2, PIK3R3, HIF1A, STAT1, CCNA1, CCNE1, STK4, TGFB3, CRKL, PTCH1, RALA, MITF, SLC2A1, STAT5A, VEGFC, RAC1, JAK1, BID, TGFBR2, BAX, MAPK1, WNT5A, MAPK10, PIK3R5, TFG, PIK3CB, CEBPA, NFKBIA, PTEN",0.125518182300534,0.000434511774017692,FALSE +"transcriptomics","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.47895,1.39,0.0906,4741,0.666,"DHDH, UGT2B17, GUSB, RPEL1, DCXR",1.04287180232319,0.176525770829699,FALSE +"transcriptomics","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.43515,1.28,0.122,5085,0.78,"PGLS, ALDOC, FBP1, PGM1, PFKL, FBP2, ALDOA, H6PD, G6PD, RPEL1, RBKS, DERA, PGM2",0.913640169325252,0.10790539730952,FALSE +"transcriptomics","Log2FC","KEGG_PEROXISOME",0.42548,1.23,0.159,5270,0.725,"CAT, ACOT8, GSTK1, PRDX5, PEX11A, XDH, PXMP4, ACAA1, MVK, AGXT, PEX11G, PEX2, HMGCL, EPHX2, PAOX, IDH2, ACSL1, EHHADH, PEX11B, CROT, ABCD1, ACOX1, ACSL3, PEX10, PEX13, PEX26, SCP2, PEX7, MLYCD, SLC25A17, ABCD4, PEX1, ACSL5, ACSL6",0.798602875679548,0.139661993429006,FALSE +"transcriptomics","Log2FC","KEGG_PHENYLALANINE_METABOLISM",0.40531,1.18,0.192,5148,0.722,"ALDH3B2, ALDH1A3, ALDH3B1, AOC2, NAA80, IL4I1, TAT, MAOA, MIF",0.71669877129645,0.141462802430361,FALSE +"transcriptomics","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.30436,0.881,0.653,6064,0.959,"CDS1, DGKA, PIK3R2, PLCG2, INPP4B, PLCD1, CALML3, INPP4A, PIK3CA, PIP4K2C, CDS2, PLCG1, PIK3C2G, PIK3C2B, DGKH, INPP5K, IMPA2, PIK3R3, PIP5K1C, CALML6, DGKI, ITPR3, INPPL1, INPP5J, PIK3R5, PIK3CB, DGKE, PTEN, PLCB3",0.185086818724926,0.0181813928293364,FALSE +"transcriptomics","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.31034,0.902,0.621,4098,0.97,"ALAD, CP, HMOX2, FTH1, UGT2B17, MMAB, GUSB, HMBS",0.20690839982342,0.0132282657337552,FALSE +"transcriptomics","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.41424,1.2,0.186,5270,0.673,"RXRA, ACAA1, CPT1B, PPARA, PLIN1, CYP4A22, FABP6, ACSL1, RXRB, CPT2, CPT1C, EHHADH, SLC27A6, PLTP, SLC27A1, PPARG, ACOX1, ACSL3, SCD5, SLC27A4, SCP2, OLR1, ACSL5, ACSL6",0.730487055782084,0.171984935776023,FALSE +"transcriptomics","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.20209,-0.694,0.959,14148,1,"ACOX2, HSD17B4, CYP7A1, HSD3B7, AKR1C4, CYP39A1, BAAT",0.0181813928293364,0,FALSE +"transcriptomics","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",0.5701,1.64,0.0145,4719,0.344,"RFXANK, BLNK, RAG1, JAK3, CD40, ADA, CD79A, RAG2, CD19, IL7R, CIITA, LCK, CD4",1.83863199776503,0.46344155742847,FALSE +"transcriptomics","Log2FC","KEGG_PRION_DISEASES",0.24524,0.708,0.908,5622,1,"MAPK3, CCL5, IL6, NOTCH1, PRKACA, IL1A, C9, BAX, MAPK1, EGR1",0.0419141514789149,0,FALSE +"transcriptomics","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28022,-0.912,0.589,15860,0.912,"ADCY7, PRKX, RPS6KA3, CCNA2, AKT3, MAD2L2, BUB1, CDC25C, CDC23, PIK3R1, GNAI1, PIK3CG, CCNB2, ANAPC10, PRKACB, CDK1, CCNB3, CDC25A, CCNB1, MAPK8, CPEB1, IGF1, HSP90AB1, HSP90AA1, ANAPC13, PDE3A, PDE3B",0.229884705212898,0.0400051616715838,FALSE +"transcriptomics","Log2FC","KEGG_PROPANOATE_METABOLISM",0.35657,1.03,0.382,3581,0.774,"LDHC, ACSS2, ALDH6A1, ABAT, MCEE, EHHADH, PCCB, ACSS1",0.417936637088291,0.111259039317107,FALSE +"transcriptomics","Log2FC","KEGG_PROSTATE_CANCER",0.26783,0.788,0.807,6422,1,"ERBB2, FGFR2, PDGFA, PIK3R2, IKBKB, MAPK3, PDGFB, PIK3CA, IGF1R, PDGFD, EP300, EGFR, E2F1, BRAF, CDKN1B, RELA, TCF7L1, CREB3L4, TGFA, FOXO1, BAD, PIK3R3, CCNE1, CREB3L3, CREB3L2, MAPK1, CREB5, CREB3L1, PIK3R5, PIK3CB, NFKBIA, PTEN, GSK3B, CDKN1A, CREB3",0.0931264652779296,0,FALSE +"transcriptomics","Log2FC","KEGG_PROTEASOME",-0.31612,-1.09,0.314,15132,0.576,"PSMB5, PSMD4, PSMD6, PSMC5, PSMB4, PSMA6, PSMD7, PSMC1, PSMC6, PSMD1, PSMC4, PSMB7, PSMA4, PSMA1, PSMD8, PSMB1, POMP, PSMD14",0.503070351926785,0.239577516576788,FALSE +"transcriptomics","Log2FC","KEGG_PROTEIN_EXPORT",-0.31244,-1.1,0.327,16054,0.655,"SEC61A2, SEC11A, SRPRB, SRP72, SRP9, SRP19, SEC11C, SEC63",0.485452247339714,0.183758700008217,FALSE +"transcriptomics","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.19349,0.559,0.988,8289,0.998,"GLS2, SLC9A3, SLC25A10, MDH1, SLC4A4, GLUD1, ATP1A2, AQP1, ATP1A1",0.00524305541237188,0.000869458712628891,FALSE +"transcriptomics","Log2FC","KEGG_PURINE_METABOLISM",-0.30249,-1.09,0.273,15717,0.576,"PNPT1, PRPS1, RRM2, ADCY7, PFAS, POLR3B, ENTPD8, POLR2L, RRM2B, PAICS, ADSL, APRT, GART, NPR2, RRM1, PDE6B, PNP, PRIM1, NME1, PDE6C, POLR3G, PDE8A, POLR3A, AK5, NME7, PPAT, PDE11A, PRIM2, POLE3, POLR2E, POLR3C, PDE1A, ATIC, ENTPD1, PDE4B, PDE4D, POLR2D, POLR1E, PDE3A, PDE3B, POLA1, PDE10A, PDE7B, PDE8B",0.563837352959244,0.239577516576788,FALSE +"transcriptomics","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.25943,-0.922,0.545,14988,0.92,"DHODH, POLE, NT5E, NME2, UPP2, CAD, POLR2C, POLR3K, PNPT1, RRM2, POLR3B, ENTPD8, POLR2L, RRM2B, AK3, TXNRD1, DTYMK, RRM1, PNP, PRIM1, NME1, TYMS, POLR3G, POLR3A, NME7, PRIM2, POLE3, POLR2E, POLR3C, ENTPD1, POLR2D, POLR1E, UCK2, POLA1, CTPS1",0.263603497723358,0.0362121726544447,FALSE +"transcriptomics","Log2FC","KEGG_PYRUVATE_METABOLISM",0.22031,0.632,0.974,1378,0.991,"LDHC, ACSS2, PC",0.0114410431213845,0.00392634551472468,FALSE +"transcriptomics","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.28027,0.811,0.781,5612,1,"PAK6, SSH3, BDKRB2, MYH14, BAIAP2, FGF11, ITGB2, VAV1, FGFR2, ITGB6, PDGFA, PIK3R2, ITGB8, RAC2, VAV3, LIMK2, FGD3, ITGB4, ARHGEF4, MAPK3, PPP1CA, VAV2, GSN, PDGFB, PFN4, PIK3CA, PPP1CB, PIP4K2C, BDKRB1, FGF1, SSH2, PDGFD, ITGA3, EGFR, FGFR3, ITGA2B, BRAF, TIAM1, PXN, MYL9, TIAM2, ARHGAP35, PAK2, SLC9A1, ITGA2, WASL, FGF12, PIK3R3, PIP5K1C, LIMK1, CRKL, ARHGEF7, SCIN, MYL7, RAC1, IQGAP1, PAK1, RRAS, BCAR1, ITGAX, PAK4, MAPK1",0.1073489661227,0,FALSE +"transcriptomics","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.20206,-0.714,0.876,18035,1,"PIK3C3, PRKAA2, IFNA13",0.0574958938319193,0,FALSE +"transcriptomics","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.3643,1.05,0.374,5894,0.766,"GAB1, PAK6, PIK3R2, EGLN3, VEGFB, MAPK3, PDGFB, PIK3CA, MET, EP300, RAP1A, ARNT2, BRAF, TGFA, PAK2, PGF, EPAS1, VEGFA, PIK3R3, HIF1A, TGFB3, CRKL, FLCN, SLC2A1, VEGFC, RAC1, PAK1, PAK4, MAPK1, PIK3R5, PIK3CB",0.42712839779952,0.115771230367396,FALSE +"transcriptomics","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.39819,1.15,0.23,4025,0.725,"CTSA, ACE2, ACE, ANPEP",0.638272163982407,0.139661993429006,FALSE +"transcriptomics","Log2FC","KEGG_RETINOL_METABOLISM",0.43832,1.25,0.149,5807,0.749,"ADH7, RDH16, CYP26B1, DHRS9, DHRS3, DGAT1, CYP4A22, CYP26A1, UGT2B17, CYP1A1, RDH10, RDH11, LRAT, CYP26C1, CYP2C9, CYP2A7, ALDH1A2, AWAT2, CYP2C8",0.826813731587726,0.125518182300534,FALSE +"transcriptomics","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",0.28656,0.831,0.75,3165,1,"ACP6, ACP5, MTMR1",0.1249387366083,0,FALSE +"transcriptomics","Log2FC","KEGG_RIBOSOME",-0.37924,-1.43,0.0805,14672,0.313,"RPL22L1, RPS23, RPL26, RPL21, RPL13A, RPS24, RPL10A, RPL37A, RPS11, RPS27A, RPL35, RPL10, RPL26L1, RPL34, RPL27A, RPLP0, RPL11, RPL32, RPS8, RPL18, RPS27, RPL9, RPS20, RPS10, RPS6, RPL4, RPL5, RPL14, RPSA, RPS13, RPS7, RPS19, RSL24D1, RPS12, RPL6, RPS4Y1, RPS16, RPL17",1.09420411963213,0.504455662453552,FALSE +"transcriptomics","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.42041,1.22,0.159,3761,0.738,"TRADD, TRAF6, DHX58, MAPK13, MAVS, IRF3, CXCL10, IKBKB, IFNB1, MAP3K1, TKFC, FADD, ISG15, IFIH1, DDX58, NLRX1, IL12B, CASP10, RELA, MAPK11, IKBKE",0.798602875679548,0.131943638176958,FALSE +"transcriptomics","Log2FC","KEGG_RNA_DEGRADATION",-0.39068,-1.36,0.125,15014,0.372,"CNOT7, LSM2, EXOSC6, LSM1, LSM5, CNOT1, PNPT1, DCP1A, LSM7, EDC4, LSM3, EXOSC9, CNOT10, EXOSC5, EXOSC3, PAPOLA, TTC37, ZCCHC7, EXOSC10, MTREX, ENO1, DCP2, CNOT9, ENO3, EXOSC8, HSPA9, DCP1B, HSPD1",0.903089986991944,0.429457060118102,FALSE +"transcriptomics","Log2FC","KEGG_RNA_POLYMERASE",-0.36582,-1.3,0.121,17492,0.435,"POLR3G, POLR3A, POLR2E, POLR3C, POLR2D, POLR1E",0.91721462968355,0.361510743045363,FALSE +"transcriptomics","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",-0.20795,-0.71,0.923,17399,1,"SCLY, MAT2A, MARS2, SEPHS1, TRMT11",0.0347982989740879,0,FALSE +"transcriptomics","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.2741,0.799,0.78,4622,1,"LAMA3, TRAF6, RXRA, TRAF4, PIK3R2, LAMB3, LAMC2, IKBKB, PIK3CA, RXRB, MAX, ITGA3, E2F1, ITGA2B, CDKN1B, RELA, LAMA5, PIAS3, LAMB1, ITGA2, PIK3R3",0.10790539730952,0,FALSE +"transcriptomics","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.44073,1.27,0.127,4358,0.786,"SNAP23, STX16, STX10, VAMP8, STX19, YKT6, STX17, VTI1B, TSNARE1, STX3, GOSR2, SNAP29, BET1, USE1, STX5, BET1L",0.896196279044043,0.104577453960592,FALSE +"transcriptomics","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",0.24714,0.716,0.895,8272,1,"ARSA, SPTLC2, NEU1, ASAH1, PLPP3, DEGS2, SPHK2, GLB1, SPHK1, GBA, SGMS2, SGPP1, SPTLC1, ENPP7, UGCG, SMPD3, SMPD2, SGPP2, NEU2, SMPD1, UGT8",0.048176964684088,0,FALSE +"transcriptomics","Log2FC","KEGG_SPLICEOSOME",-0.28279,-0.988,0.477,14820,0.769,"HSPA1A, SNRNP27, DDX23, LSM2, SF3A3, SF3B1, SNRPB, SNRPF, PRPF8, BCAS2, LSM5, PRPF3, THOC1, SRSF3, SF3A2, DDX39B, EIF4A3, LSM7, SF3B4, TCERG1, RBM22, U2AF1, LSM3, SNRNP40, SYF2, DDX5, HNRNPK, DHX15, HNRNPA1L2, BUD31, PQBP1, PRPF40A, THOC2, PRPF4, SNRPA1, RBM8A, ALYREF, CDC5L, RBM17, SRSF7, SNRPE, PRPF18, SNRPD2, CDC40, SNRPC, RBMX, SRSF1, HNRNPA3, HSPA8, HNRNPM, HNRNPA1, HNRNPC, SF3B5, MAGOHB, PPIH, HNRNPU, PPIE, TXNL4A, SRSF10",0.321481620959886,0.114073660198569,FALSE +"transcriptomics","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.44369,1.29,0.107,7075,0.846,"HK2, GYS1, GCK, GAA, PGM1, GANC, UGT2B17, GUSB, HK1, UXS1, PYGL, PGM2, ENPP1, MGAM, PYGB, AMY1A, UGP2, AGL",0.97061622231479,0.0726296369609765,FALSE +"transcriptomics","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.61834,1.8,0.00564,5003,0.385,"MSMO1, DHCR24, LIPA, SC5D, SQLE, FDFT1, HSD17B7, CEL, NSDHL, DHCR7, LSS, TM7SF2",2.24872089601666,0.414539270491499,FALSE +"transcriptomics","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38862,1.12,0.267,4669,0.711,"CYP11B1, CYP1B1, SULT2B1, SRD5A1, COMT, SRD5A3, CYP7B1, UGT2B17, HSD17B7, SULT1E1, CYP1A1, HSD17B8",0.573488738635425,0.148130399270234,FALSE +"transcriptomics","Log2FC","KEGG_SULFUR_METABOLISM",0.55174,1.6,0.0275,5093,0.347,"SULT2B1, CHST12, SULT1A2, SUOX, SULT1A4, CHST11, SULT1E1, SULT1A3",1.56066730616974,0.459670525209126,FALSE +"transcriptomics","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.21402,-0.746,0.894,18576,1,"SSB, GRIN2B",0.0486624812040823,0,FALSE +"transcriptomics","Log2FC","KEGG_TASTE_TRANSDUCTION",0.22218,0.659,0.943,6205,0.987,"KCNB1, SCNN1A, ADCY4, TAS2R1, SCNN1G, TAS1R3, ADCY6, GNAS, TAS2R3, GRM4, TAS2R31, SCNN1B, ITPR3, PRKACA, TAS2R4, TAS2R38, TAS2R5",0.0254883072626717,0.00568284733036327,FALSE +"transcriptomics","Log2FC","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.24456,0.712,0.884,3450,1,"GGT7, GGT6",0.0535477349869269,0,FALSE +"transcriptomics","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.41775,1.21,0.185,5412,0.676,"MVK, HMGCS1, MVD, DHDDS, HMGCR",0.732828271596986,0.170053304058364,FALSE +"transcriptomics","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.21463,-0.754,0.826,15652,1,"SMAD7, TFDP1, RHOA, BMPR2, SMAD5, PITX2, BMP8B, PPP2CB, PPP2R1B, ID3, SMAD4, SKP1, SMURF2, BMPR1A, INHBE, SMAD9, BMP8A, ID2, TGFB1, CDKN2B, E2F5, ROCK2, BMP6, SMAD2",0.0830199526796178,0,FALSE +"transcriptomics","Log2FC","KEGG_THYROID_CANCER",0.39121,1.13,0.27,3392,0.705,"CDH1, RXRA, MAPK3, RXRB, PPARG, BRAF, TCF7L1",0.568636235841013,0.151810883008601,FALSE +"transcriptomics","Log2FC","KEGG_TIGHT_JUNCTION",0.33254,0.963,0.5,4350,0.864,"EPB41L1, PRKCD, AMOTL1, MYH14, CLDN8, CGN, CLDN9, CLDN7, CLDN4, F11R, TJP3, CRB3, TJP2, PRKCH, LLGL2, CLDN18, PRKCI, PARD6B, PATJ, CLDN11, CTTN, EXOC4, CLDN23, CLDN3, SRC, MYH15, MYL9, EXOC3, MAGI1, PRKCZ, OCLN",0.301029995663981,0.0634862575211067,FALSE +"transcriptomics","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.43206,1.25,0.145,6260,0.749,"TLR5, TRAF6, MAPK13, PIK3R2, IRF5, LBP, IRF3, TOLLIP, CXCL10, IKBKB, MAPK3, TLR3, IFNB1, PIK3CA, MYD88, FADD, CXCL11, CCL5, CD40, IL12B, CXCL9, TAB1, RELA, TLR1, MAPK11, IKBKE, IL6, TLR2, MAP3K8, IRAK4, TIRAP, TICAM1, PIK3R3, STAT1, IL12A, RAC1, TAB2, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB, NFKBIA, FOS, IRF7",0.838631997765025,0.125518182300534,FALSE +"transcriptomics","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",0.25994,0.751,0.862,5698,0.993,"CAT, CYP1B1, GCDH, KMO, EHHADH, IL4I1, CYP1A1, MAOA, IDO1, HAAO, OGDHL",0.0644927341752872,0.00305075150461883,FALSE +"transcriptomics","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",0.35999,1.04,0.393,1965,0.764,"PRKCD, HK2, PIK3R2, CACNA1D, SOCS1, GCK, IKBKB, MAPK3, INSR, PIK3CA",0.405607449624573,0.11690664142431,FALSE +"transcriptomics","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",-0.22684,-0.791,0.732,16990,1,"PRF1, PTPRN, HSPD1",0.135488918941608,0,FALSE +"transcriptomics","Log2FC","KEGG_TYROSINE_METABOLISM",0.48583,1.41,0.0685,2773,0.638,"ADH7, ALDH3B2, HEMK1, TH, ALDH1A3, ALDH3B1, COMT, AOC2, GSTZ1, NAA80, LCMT1",1.16430942850757,0.195179321278838,FALSE +"transcriptomics","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.29483,0.852,0.705,6624,1,"PAK6, CBLC, VAV1, MAPK13, PIK3R2, VAV3, DLG1, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, NCK2, CBLB, PLCG1, RELA, CHP1, MAPK11, PPP3CA, PAK2, LCK, MAP3K8, CSF2, PIK3R3, CD4, NCK1, PAK1, PAK4, MAPK1, MAP2K7, NFATC1, PIK3R5, PIK3CB, NFKBIA, GSK3B, FOS, NFATC4, GRB2, CHP2",0.151810883008601,0,FALSE +"transcriptomics","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29203,0.851,0.711,6099,0.994,"CBLC, UBOX5, ITCH, UBA7, TRAF6, UBE2H, PPIL2, SOCS1, FBXO2, SMURF1, PML, MAP3K1, FBXW7, UBE2L6, RHOBTB2, HERC1, HERC3, ANAPC2, CUL7, UBE2D4, CBLB, FBXO4, RNF7, MID1, SYVN1, UBA6, FBXW8, UBR5, UBE2C, PIAS3, KLHL13, UBE3B, UBE2W, HUWE1, NEDD4L, UBE2F, TRIM32, UBE2Q1, WWP2, DDB1, SIAH1, FZR1, UBE4A, UBE2E1, UBE3C, DET1, UBE2O, UBE2E2, STUB1, UBA3, ANAPC11, UBE2M, UBE2Z",0.148130399270234,0.00261361560268669,FALSE +"transcriptomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.54815,-1.97,0,13596,0.203,"VARS2, LARS2, BCAT1, PDHA1, IARS2",Inf,0.692503962086787,TRUE +"transcriptomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.42231,1.21,0.205,3822,0.676,"MCCC1, ACAA1, HIBADH, ACAD8, ALDH6A1, ABAT, HMGCL, HMGCS1, MCEE, ACADS, EHHADH, PCCB, IL4I1, AUH",0.688246138944246,0.170053304058364,FALSE +"transcriptomics","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.28813,0.84,0.732,4348,1,"PRKCD, PLA2G12A, KCNMB3, CACNA1D, PLA2G6, CALML3, PLA2G4B, ADORA2B, MAPK3, ADORA2A, PPP1CA, PRKCH, ADCY5, CYP4A22, PPP1CB, ADCY4, PLA2G10, PLA2G4E, BRAF, ADCY6, MYL9, PLA2G2C, EDNRA, KCNMB4, GNAS, GNAQ",0.135488918941608,0,FALSE +"transcriptomics","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.27394,0.796,0.79,7785,1,"DYNLL2, AQP3, RAB5B, ARHGDIB, ADCY6, CREB3L4, GNAS, DYNC2LI1, DCTN5, CREB3L3, PRKACA, CREB3L2, RAB11B, RAB5C, CREB5, CREB3L1, CREB3, ADCY9, ADCY3, NSF, CREB1, RAB11A, PRKACG, DCTN1",0.102372908709559,0,FALSE +"transcriptomics","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.37587,1.09,0.308,5894,0.757,"PLA2G12A, MAPK13, PIK3R2, PLCG2, RAC2, PLA2G6, PLA2G4B, NOS3, HSPB1, MAPK3, PIK3CA, PLA2G10, PLA2G4E, MAPKAPK3, PLCG1, SPHK2, PXN, SRC, CHP1, MAPK11, PPP3CA, PLA2G2C, BAD, VEGFA, PIK3R3, SPHK1, MAPKAPK2, RAC1, MAPK1, NFATC1, PIK3R5, PIK3CB",0.511449283499556,0.120904120499927,FALSE +"transcriptomics","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",0.35881,1.03,0.411,7679,0.774,"ERO1A, PLCG2, ATP6V1C2, TJP2, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP6AP1, KDELR3, PLCG1, PDIA4, GNAS, TCIRG1, KCNQ1, ATP6V1G1, SEC61G, ATP6V0A4, PRKACA, KDELR2, ATP6V1C1, TJP1, ATP6V1E1, ADCY9, ADCY3, SEC61B, ATP6V0C, PRKACG, ATP6V1E2, ATP6V0E2",0.386158178123931,0.111259039317107,FALSE +"transcriptomics","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.26233,0.756,0.851,3633,0.994,"MYH14, ITGB2, RAC2, DAG1, CD40, EIF4G1, CAV1, MYH15",0.0700704399154121,0.00261361560268669,FALSE +"transcriptomics","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.25146,0.732,0.892,2541,1,"WNT3A, WNT9A, TBL1XR1, WNT7B, DAAM1, FZD10, PORCN, WNT7A, RAC2, SENP2, WNT4, FRAT1, CTNNBIP1, DVL3, CAMK2G, FRAT2, CSNK1E, WNT10A, LRP5, CSNK1A1, EP300, VANGL2",0.0496351456238769,0,FALSE +"proteomics","Log2FC","KEGG_ABC_TRANSPORTERS",-0.56716,-1.62,0.0638,8609,0.465,"ABCC5, ABCA1, ABCG1, ABCA10, ABCB1, ABCC10, ABCB7, ABCB5, ABCC1, ABCC4, ABCC6, ABCB4, ABCB10, ABCA7, ABCA3, ABCA13, ABCC2, ABCB11",1.19517932127884,0.332547047110046,FALSE +"proteomics","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.42626,1.2,0.237,2845,0.633,"PIK3CD, RARA, RUNX1, LEF1, CCND1, KRAS, NRAS, FLT3, PIK3R2, PIK3CA, STAT3, IKBKB, HRAS, EIF4EBP1, MAPK3, GRB2, RPS6KB2, SOS2, TCF7L1, MAPK1",0.625251653989896,0.198596289982645,FALSE +"proteomics","Log2FC","KEGG_ADHERENS_JUNCTION",0.47199,1.3,0.143,1296,0.559,"RAC2, NECTIN4, CDH1, SNAI2, CTNND1, ACTN3, CTNNA1, NECTIN1, CTNNA2, CTNNB1, BAIAP2, ERBB2, RAC3, EP300, LMO7, PTPN6, PTPRF, EGFR, LEF1",0.844663962534938,0.252588192113577,FALSE +"proteomics","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.31768,0.898,0.564,2689,0.975,"CD36, RXRA, RXRG, IRS1, ACSL4, ACSL1, PRKCQ, ACSL6, SLC2A1, ACSL5, STAT3, IKBKB, NFKBIA, PRKAB2, ACSL3",0.248720896016658,0.0109953843014632,FALSE +"proteomics","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.24638,0.686,0.888,2010,0.993,"GLUL, ABAT, GLUD2, GFPT1, GPT2",0.051587034221399,0.00305075150461883,FALSE +"proteomics","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.56793,1.6,0.051,3523,0.423,"SCNN1A, ATP1A2, PIK3CD, IRS1, PDPK1, KRAS, HSD11B2, PIK3R2, PIK3CA, MAPK3, SCNN1B, MAPK1, SFN, ATP1A3, ATP1A4, ATP1A1, PRKCG",1.29242982390206,0.373659632624958,FALSE +"proteomics","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.58978,1.64,0.0361,2132,0.61,"FADS2, PLA2G12A, PLA2G2A, ACOX1, ACOX3",1.44249279809434,0.214670164989233,FALSE +"proteomics","Log2FC","KEGG_ALZHEIMERS_DISEASE",-0.26665,-0.78,0.759,8102,0.872,"PSEN1, NDUFV1, UQCRC1, COX7A2, NDUFA6, ERN1, NDUFC1, BAD, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, NDUFA2, NDUFS3, ATP5F1D, MAPT, ATP5PF, NDUFB4, HSD17B10, NDUFA3, ITPR2, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, IDE, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, ATP5F1C, PPP3CC, ITPR1, PLCB2, ATP5F1B, ATP5PB, ATP5PD, NDUFB2, ATP5MC2, BACE2, CASP7, PLCB4, PSEN2",0.11975822410452,0.0594835150674328,FALSE +"proteomics","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.38256,-1.14,0.266,7208,0.55,"AARS2, FARSB, FARS2, SARS2, LARS2, DARS2, YARS2, MTFMT, EARS2, WARS2, RARS2",0.575118363368933,0.259637310505756,FALSE +"proteomics","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.27352,0.774,0.763,2412,0.997,"HK1, MPI, NPL, RENBP, PGM1, NAGK, GMPPA, GFPT1, HK2, GALT, PGM2, GALE",0.11747546204512,0.00130484168834428,FALSE +"proteomics","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.34389,-0.999,0.433,10318,0.673,"NEFM, MAP2K6, MAPK11, SOD1, NEFL, PRPH, PRPH2, NEFH",0.363512103646635,0.171984935776023,FALSE +"proteomics","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.32022,0.896,0.562,3597,0.965,"CTSS, IFI30, CD74, CALR, LGMN, HSPA6, TAPBP, HSPA1A, PSME2, CREB1, PSME1, CTSB",0.250263684430939,0.0154726866562074,FALSE +"proteomics","Log2FC","KEGG_APOPTOSIS",0.23693,0.671,0.919,2534,0.993,"IL1R1, BCL2, IL1RAP, ENDOD1, PIK3CD, CASP10, MYD88, PPP3R1, PPP3CA, PPP3CB, PPP3R2, PIK3R2, TP53, CASP6, PIK3CA, IKBKB, PRKAR1B, CAPN2, NFKBIA, ENDOG",0.0366844886138887,0.00305075150461883,FALSE +"proteomics","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",0.4694,1.33,0.129,2120,0.577,"GGT5, PTGS2, PLA2G12A, EPHX2, ALOX5, GPX6, GPX7, PTGES, PLA2G2A, GPX1, GGT7, GPX3",0.889410289700751,0.238824186844269,FALSE +"proteomics","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34932,0.983,0.459,2841,0.889,"GLUL, OAT, PRODH, PRODH2, GATM, ARG1, NOS3, CKMT1A, CKMT2, GLUD2, NOS1, P4HA2, NAGS, ARG2, P4HA1, PYCR3, MAOA, ASL, OTC, ALDH18A1",0.338187314462739,0.0510982390297863,FALSE +"proteomics","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.33473,0.951,0.492,1866,0.91,"ITGB6, ITGB8, ACTN3, CTNNA1, ITGB4, CTNNA2, CTNNB1, DSC2, ITGA2, ITGA11, SGCG, LEF1, ITGA4, CACNA1F, GJA1, ITGA3, PKP2",0.30803489723264,0.0409586076789064,FALSE +"proteomics","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.61182,-1.82,0.024,7847,0.415,"ALDH9A1, ALDH1B1, ALDH3A2, ALDH2, ALDH7A1",1.61978875828839,0.381951903287907,FALSE +"proteomics","Log2FC","KEGG_AXON_GUIDANCE",0.46405,1.33,0.106,2598,0.577,"RAC2, PAK5, PAK6, NGEF, EPHA1, EPHB2, RGS3, ROBO2, NTN4, SEMA4B, NFATC4, EFNB2, EFNA1, SEMA7A, RAC3, PLXNB2, PPP3R1, SEMA3A, SEMA3C, PPP3CA, PPP3CB, PLXNA2, EPHB4, PPP3R2, EPHA4, SEMA4D, KRAS, NRAS, SLIT2, EPHB3, EPHB1, RHOA, NFATC1, SLIT1, SLIT3, RAC1, MET, LIMK2, HRAS, MAPK3, PLXNA1, ABLIM1, NFATC3, NTN1, NFATC2, RHOD",0.97469413473523,0.238824186844269,FALSE +"proteomics","Log2FC","KEGG_BASAL_CELL_CARCINOMA",-0.25512,-0.74,0.815,10364,0.905,"WNT10A, GLI2, GLI3",0.0888423912600234,0.0433514207947967,FALSE +"proteomics","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.41284,-1.16,0.279,7232,0.549,"GTF2A1, STON1, GTF2E2, TAF10, TBP, GTF2H3, GTF2A2, GTF2F2, GTF2H4, GTF2H1, TAF12, GTF2H2, GTF2F1, TAF13, TBPL1",0.554395796726402,0.260427655549908,FALSE +"proteomics","Log2FC","KEGG_BASE_EXCISION_REPAIR",-0.24796,-0.739,0.841,9965,0.893,"POLL, NTHL1, MUTYH",0.0752040042020878,0.0491485411114536,FALSE +"proteomics","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.28968,-0.833,0.642,7434,0.807,"SRM, ECHS1, MLYCD, ALDH9A1, EHHADH, ALDH1B1, ALDH3A2, ALDH2, ALDH7A1",0.192464971931147,0.0931264652779296,FALSE +"proteomics","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.35293,-1.04,0.339,9642,0.655,"HACD1, YOD1, PECR, ACOT7, ELOVL2",0.469800301796918,0.183758700008217,FALSE +"proteomics","Log2FC","KEGG_BLADDER_CANCER",0.463,1.3,0.142,2596,0.559,"CDH1, VEGFA, THBS1, ERBB2, VEGFC, EGFR, CDK4, CCND1, KRAS, NRAS, CDKN1A, MMP2, TP53, HRAS, MAPK3, CDKN2A",0.847711655616944,0.252588192113577,FALSE +"proteomics","Log2FC","KEGG_BUTANOATE_METABOLISM",0.29975,0.842,0.662,891,1,"ABAT, HMGCS1, ACSM3, BDH2",0.1791420105603,0,FALSE +"proteomics","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.52452,1.46,0.0918,2561,0.653,"RAC2, DAPP1, CARD11, NFATC4, PIK3CD, RAC3, LYN, CD79A, PTPN6, PIK3AP1, PPP3R1, VAV1, PPP3CA, VAV2, PPP3CB, PPP3R2, KRAS, NRAS, CD81, NFATC1, PIK3R2, RAC1, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, VAV3, GRB2, NFATC3, NFATC2, SOS2",1.03715731879876,0.185086818724926,FALSE +"proteomics","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.24843,0.692,0.875,1708,1,"TNNC1, ERBB3, GNA15, TNNC2, NOS3, ERBB2, ERBB4, ATP2A3, PPP3R1, EGFR, PPP3CA, PPP3CB, PPP3R2, NOS1, PTK2B, CACNA1F, CACNA1A",0.0579919469776868,0,FALSE +"proteomics","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.35378,0.989,0.426,840,0.889,"TNNC1, MYH7, ATP1A2, SLC9A1",0.370590400897281,0.0510982390297863,FALSE +"proteomics","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.48094,1.37,0.106,793,0.611,"CLDN18, CLDN4, CLDN7, CDH15, CDH3, CDH5, SDC4, ITGAL, SDC1, ITGB8, ITGB2, CLDN3, CDH1, F11R, CLDN6, VCAN, JAM2, SDC2, NECTIN1, SDC3, CD274, ICAM2",0.97469413473523,0.213958789757446,FALSE +"proteomics","Log2FC","KEGG_CELL_CYCLE",0.18042,0.515,0.994,2700,1,"FZR1, CDC6, WEE1, EP300, CDC7, CHEK2, ANAPC11, CDKN1C, CDK4, SKP2, CCND1, CCNB1, BUB1, CDKN1A, CCNA2, RBL1, CREBBP, TP53, PCNA, CHEK1, BUB1B, CDKN2A, HDAC1, ZBTB17",0.00261361560268669,0,FALSE +"proteomics","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.28479,-0.805,0.704,10271,0.851,"PLCB4, CXCL10, DOCK2, ADCY6, GNG7, SHC4, CCR10, CCR9, WAS, CXCL5, RASGRP2, CXCL14",0.152427340857888,0.0700704399154121,FALSE +"proteomics","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.23803,0.661,0.904,2652,0.985,"PIK3CD, MECOM, RUNX1, CDK4, CCND1, KRAS, NRAS, CDKN1A, BCR, PIK3R2, TP53, PIK3CA, CTBP1, IKBKB, HRAS, MAPK3, NFKBIA, CBLB, GRB2, SOS2, CDKN2A, HDAC1",0.0438315695246367,0.00656376950238827,FALSE +"proteomics","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.51999,1.45,0.103,2428,0.632,"BHLHE41, PER2, NR1D1, CSNK1E, ARNTL",0.987162775294828,0.199282921717615,FALSE +"proteomics","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.18745,-0.538,0.989,2896,1,"IDH1, SUCLG2, ACO1, DLD, ACLY, ACO2, DLST, PCK1, MDH2, MDH1, SDHA, SUCLG1, OGDHL, DLAT, OGDH, PC, SUCLA2, IDH3B, SDHB, CS, SDHC, IDH3A, PDHB, PDHA1, IDH3G, FH, SDHD, PCK2",0.0048037084028206,0,FALSE +"proteomics","Log2FC","KEGG_COLORECTAL_CANCER",0.32298,0.901,0.565,2210,0.982,"RAC2, BCL2, CTNNB1, PIK3CD, RAC3, LEF1, CCND1, KRAS, RHOA, PIK3R2, TP53, RAC1, PIK3CA",0.247951552180562,0.00788851221305034,FALSE +"proteomics","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.403,1.13,0.278,944,0.676,"CFI, CFB, SERPINA1, TFPI, FGG, FGB, SERPINA5, MASP1, PLAT, PLAU, SERPINC1, F3",0.555955204081924,0.170053304058364,FALSE +"proteomics","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.39207,-1.17,0.27,8054,0.568,"APIP, GOT1, MAT2B, SDS, GOT2, CBS, MAT2A, MAT1A, MTAP, AMD1, CDO1",0.568636235841013,0.245651664288981,FALSE +"proteomics","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.46198,-1.33,0.127,10106,0.632,"TNFRSF10A, TGFB1, BMPR2, CXCL10, INHBA, TNFRSF19, ACVR2A, CD70, TNFSF9, TGFB2, CD40, BMPR1A, TNFRSF10C, CCR10, CCR9, IL1A, IFNAR2, CXCL5, INHBE, CXCL14, PDGFRA",0.896196279044043,0.199282921717615,FALSE +"proteomics","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.16559,0.465,0.998,2883,1,"CASP1, RIPK3, DDX58, IL18, IKBKB, NFKBIA, IKBKE, IL1B",0.000869458712628891,0,FALSE +"proteomics","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",-0.30863,-0.874,0.556,10453,0.751,"ADCY6, TGFB2, TPM2, LAMA2, CACNA2D2, SGCD, CACNA2D1, ITGA10, DES",0.254925208417942,0.124360062995832,FALSE +"proteomics","Log2FC","KEGG_DNA_REPLICATION",-0.20491,-0.611,0.932,2252,1,"PCNA, LIG1, RFC5, POLD4, RFC2, RFC3, POLE, RFC1, RPA3, POLE4, POLD3, RFC4, MCM4, POLE3, MCM6, POLD1, MCM5, MCM7, RPA2, SSBP1, RNASEH2A, MCM3, POLE2, POLD2, FEN1, PRIM1, RPA1, MCM2, DNA2, RNASEH1, PRIM2, POLA1, POLA2, RNASEH2C, RNASEH2B",0.0305840876460186,0,FALSE +"proteomics","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.55702,1.6,0.044,2561,0.423,"ETS2, ETV6, EGFR, NOTCH3, KRAS, PIWIL2, MAPK3, GRB2, SOS2",1.35654732351381,0.373659632624958,FALSE +"proteomics","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.35951,0.997,0.413,1430,0.901,"FMO5, GSTA5, ADH4, ADH7, FMO2, FMO4, MGST2, ALDH1A3, MGST1, ALDH3B1, FMO3",0.384049948343599,0.045275209020937,FALSE +"proteomics","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.42011,-1.22,0.232,9395,0.519,"GMPS, CYP3A5, UCK2, UMPS, NAT2, CYP3A7",0.6345120151091,0.284832642151542,FALSE +"proteomics","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.43662,1.22,0.201,1082,0.624,"ITGB6, TNC, SDC4, CD36, SDC1, ITGB8, ITGB4, SDC2, LAMC2, LAMB3, THBS1, SDC3, CD47, ITGA2, ITGA11, LAMA3, LAMA4",0.696803942579511,0.204815410317576,FALSE +"proteomics","Log2FC","KEGG_ENDOCYTOSIS",0.2991,0.835,0.704,2726,1,"EPN3, PSD4, ERBB3, ARRB1, CHMP2B, ASAP3, RAB11FIP1, RAB11FIP4, ERBB4, DNAJC6, ARAP3, EGFR, GRK2, AGAP1, TRAF6, PRKCZ, AGAP2, RAB22A, EHD2, PRKCI, PARD6G, ITCH, ARF6, RAB11B, RAB31, RAB11A, CHMP4C, MET, LDLRAP1, CHMP4A, CHMP4B, CHMP2A, CLTCL1, PARD6B, HRAS, EPS15, CBLB, IGF1R, HSPA6, VPS37B, RAB5B, PARD6A, EPN1",0.152427340857888,0,FALSE +"proteomics","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.50929,1.41,0.104,2624,0.58,"CDH1, CTNNA1, CTNNA2, CTNNB1, ERBB2, PIK3CD, EGFR, LEF1, PDPK1, CCND1, KRAS, NRAS, PIK3R2, TP53, PIK3CA, HRAS, MAPK3, GRB2, SOS2, TCF7L1",0.98296666070122,0.236572006437063,FALSE +"proteomics","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.31162,0.876,0.613,1141,0.971,"CXCL1, F11R, JAM2, MAPK12, MAPK13, LYN, EGFR",0.212539525481585,0.0127807700919951,FALSE +"proteomics","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.41192,1.17,0.249,2561,0.666,"EREG, ERBB3, AREG, PAK5, PAK6, TGFA, ERBB2, PIK3CD, ERBB4, EGFR, GAB1, KRAS, NRAS, CDKN1A, PIK3R2, PIK3CA, HRAS, EIF4EBP1, MAPK3, CAMK2D, ABL2, CBLB, GRB2, RPS6KB2, SOS2",0.603800652904264,0.176525770829699,FALSE +"proteomics","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.4815,1.36,0.109,2108,0.608,"LPCAT2, PLA2G12A, PAFAH2, PLA2G2A, LPCAT4, LPCAT1, PLPP3",0.962573502059376,0.216096420727265,FALSE +"proteomics","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.299,0.853,0.635,2361,1,"ADH4, ADH7, ACSL4, ACAA1, ACSL1, ACOX1, CPT2, ACSL6, ADH1C, ACOX3, ACADM, ACSL5, ACADS",0.197226274708024,0,FALSE +"proteomics","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.46449,1.33,0.143,2664,0.577,"RAC2, PRKCD, MAPK12, PIK3CD, MAPK13, PLA2G12A, RAC3, LYN, VAV1, LCP2, VAV2, PLA2G2A, PDPK1, KRAS, NRAS, PIK3R2, RAC1, PIK3CA, HRAS, MAPK3, VAV3, GRB2, SOS2, MAPK14",0.844663962534938,0.238824186844269,FALSE +"proteomics","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.3637,1.02,0.402,2557,0.853,"RAC2, PRKCD, AMPH, ASAP3, SCIN, PIK3CD, LYN, VAV1, GSN, MYO10, HCK, VAV2, MARCKS, MARCKSL1, PLA2G4F, ARF6, PTPRC, PIK3R2, PLPP3, RAC1, PIK3CA, LIMK2, MAPK3, VAV3, RPS6KB2",0.39577394691553,0.069050968832477,FALSE +"proteomics","Log2FC","KEGG_FOCAL_ADHESION",0.29325,0.831,0.658,1355,0.97,"ITGB6, TNC, RAC2, BCL2, PAK5, PAK6, ITGB8, VEGFA, ACTN3, ITGB4, LAMC2, LAMB3, THBS1, CTNNB1, ERBB2, VEGFC, PIK3CD, RAC3, VAV1, ITGA2, ITGA11, LAMA3, LAMA4, EGFR, VAV2, PDPK1, CCND1",0.181774106386044,0.0132282657337552,FALSE +"proteomics","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.38519,1.08,0.304,2050,0.734,"ALPI, ALPP, ALPG, FPGS, PTS",0.517126416391246,0.134303940083929,FALSE +"proteomics","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.59056,1.64,0.044,2113,0.61,"ALDOB, FBP1, ALDOC, PFKFB4, MTMR7, HK1, FBP2, PFKFB2, MPI, GMPPA, MTMR1, HK2",1.35654732351381,0.214670164989233,FALSE +"proteomics","Log2FC","KEGG_GALACTOSE_METABOLISM",0.35287,0.993,0.439,2908,0.895,"B4GALT1, HK1, PGM1, HK2, GAA, GALT, PGM2, GALE, UGP2, MGAM",0.357535479757879,0.048176964684088,FALSE +"proteomics","Log2FC","KEGG_GAP_JUNCTION",-0.39068,-1.14,0.27,9590,0.55,"GNAI1, ITPR1, PLCB2, TUBA8, TUBA3C, TUBB6, GRM5, PLCB4, MAP2K5, ADCY6, TUBB2B, PDGFRA",0.568636235841013,0.259637310505756,FALSE +"proteomics","Log2FC","KEGG_GLIOMA",-0.32991,-0.976,0.411,10540,0.658,"CDK6, SHC4, PDGFRA",0.386158178123931,0.181774106386044,FALSE +"proteomics","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.28325,0.798,0.734,2603,1,"GGT5, GSTA5, MGST2, GPX6, GPX7, MGST1, GSTK1, GPX1, IDH2, GGT7, GPX3, MGST3, G6PD, ANPEP, GSTT2",0.134303940083929,0,FALSE +"proteomics","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.32775,0.918,0.53,2176,0.968,"LIPC, LPL, MGLL, LIPG, DGKA, DGKH, MBOAT2, DGKB, PLPP3, DGAT1",0.275724130399211,0.0141246426916063,FALSE +"proteomics","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.34171,0.951,0.489,3460,0.91,"PEMT, DGKA, LPCAT2, PLA2G12A, CDS1, DGKH, PLA2G2A, CHKA, LPCAT4, MBOAT2, LPCAT1, DGKB, LYPLA2, PLPP3, PISD, PCYT2, LPGAT1, GPD1L, MBOAT1, DGKZ, PLA2G4A, GPD2, CHKB, LPCAT3, DGKQ",0.31069114087638,0.0409586076789064,FALSE +"proteomics","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.30658,-0.907,0.554,9064,0.727,"CBS, AGXT, ALAS1, PHGDH, PIPOX, PSAT1, MAOB, GLDC",0.25649023527157,0.138465589140962,FALSE +"proteomics","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.45991,1.29,0.171,881,0.563,"ALDOB, PGAM2, FBP1, ALDOC, ADH4, ADH7, GALM, HK1, FBP2, ACSS2, ALDH1A3",0.767003889607846,0.249491605148654,FALSE +"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.34596,-0.994,0.419,9904,0.667,"XYLT1, CSGALNACT2, CHST3, CHST7",0.377785977033705,0.175874166083451,FALSE +"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.34182,0.951,0.481,3070,0.91,"HS6ST2, HS6ST1, XYLT2, EXT2, EXT1, EXTL3",0.317854923626168,0.0409586076789064,FALSE +"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66613,1.87,0.0122,2887,0.688,"B4GALT1, FUT8, B4GALT3, ST3GAL1, B3GNT2, B4GALT4",1.91364016932525,0.162411561764489,FALSE +"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.43357,-1.29,0.151,9910,0.551,"HEXA, IDUA, ARSB, HYAL1",0.821023052706831,0.258848401148215,FALSE +"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.51004,-1.53,0.0609,7952,0.508,"HEXB, ST3GAL5, HEXA, B4GALNT1",1.21538270736712,0.294136287716081,FALSE +"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.56837,1.6,0.0467,725,0.423,"B3GALNT1, B3GALT5",1.33068311943389,0.373659632624958,FALSE +"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.62329,1.76,0.0173,2178,0.804,"B3GNT3, FUT3, B4GALT1, B3GALT5, B4GALT3, ST3GAL4, B3GNT2",1.7619538968712,0.0947439512515487,FALSE +"proteomics","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.25881,-0.775,0.742,8687,0.868,"PIGN, PIGQ, PIGB, PIGM, PIGX",0.129596094720973,0.0614802748235081,FALSE +"proteomics","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.16598,0.465,0.997,4328,1,"AFMID, GLYCTK, ACO1, ACO2, MDH2, MTHFD2L, MDH1, MTHFD1",0.00130484168834428,0,FALSE +"proteomics","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.23616,0.661,0.923,3427,0.985,"PRKCD, MAPK12, MAPK13, PLA2G12A, CGA, EGFR, PLA2G2A, KRAS, NRAS, PTK2B, CACNA1F, MAP3K1, MMP2, PLCB1, HRAS, MAPK3, CAMK2D, GRB2, SOS2, MAPK14, MAPK1, PLA2G4A, MMP14, GNA11, ADCY9, CDC42, CAMK2B, PLCB3, SOS1, ADCY5",0.0347982989740879,0.00656376950238827,FALSE +"proteomics","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.30481,-0.886,0.575,10364,0.756,"WNT10A, GLI2, GLI3",0.24033215531037,0.121478204498793,FALSE +"proteomics","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.29233,0.811,0.697,1843,0.991,"IL1R1, CD36, CD9, ITGA2, ITGA4, ITGA3, FLT3, CD33",0.156767221901991,0.00392634551472468,FALSE +"proteomics","Log2FC","KEGG_HISTIDINE_METABOLISM",-0.34944,-1.01,0.37,10443,0.665,"ALDH2, MAOB, ALDH7A1, ALDH3A1",0.431798275933005,0.177178354696895,FALSE +"proteomics","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",-0.38362,-1.13,0.291,9496,0.537,"RAD50, MUS81, MRE11, RAD52",0.536107011014093,0.270025714300444,FALSE +"proteomics","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.35692,-1.03,0.397,7298,0.643,"NDUFV2, COX7C, POLR2L, NDUFS4, SDHB, NDUFB5, POLR2I, COX4I1, POLR2A, SDHC, COX6B1, DCTN4, COX6A1, POLR2E, CYCS, DCTN2, DNAL1, TBP, NDUFV1, UQCRC1, COX7A2, NDUFA6, NDUFC1, POLR2H, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, SLC25A6, BAX, NDUFA2, DCTN1, TFAM, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, VDAC1, NDUFA3, HIP1, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, DNAH3, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, TGM2, ATP5F1C, SOD2, AP2A2, ITPR1, PLCB2, ATP5F1B, ATP5PB, SLC25A4, ATP5PD, NDUFB2, ATP5MC2, TBPL1, GRM5, PLCB4, BBC3, SOD1",0.401209493236885,0.191789027075778,FALSE +"proteomics","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.32547,-0.956,0.469,10552,0.655,"TGFB2, PRKAA2, TPM2, LAMA2, CACNA2D2, SGCD, CACNA2D1, ITGA10, DES",0.328827157284917,0.183758700008217,FALSE +"proteomics","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.25705,0.733,0.841,3346,1,"IMPA2, INPP4B, PIK3CD, PIP4K2C, ALDH6A1, PLCB1, PIK3C2B, PIK3CA, PI4KA, PLCD1, ISYNA1, INPP5B, INPP5A, PIP4K2A, PI4KB, SYNJ2, PLCB3",0.0752040042020878,0,FALSE +"proteomics","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.20113,0.572,0.977,2750,1,"FBP1, PIK3CD, HK1, FBP2, PTPRF, IRS1, PDPK1, KRAS, NRAS, PRKCZ, PYGB, PRKCI, EXOC7, MKNK1, PIK3R2, HK2, PIK3CA, PTPN1, PPP1R3D, IKBKB, PRKAR1B, HRAS, EIF4EBP1, MAPK3, RHEB, CBLB, GRB2, RPS6KB2, SOS2, PRKAB2, PYGL, GYS1",0.0101054362812269,0,FALSE +"proteomics","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.50265,-1.49,0.0621,10060,0.532,"ICOSLG, TGFB1, CD40, CCR10, CCR9",1.20690839982342,0.274088367704952,FALSE +"proteomics","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.27492,0.779,0.737,2561,0.998,"SPRY2, LIFR, PIK3CD, EP300, PTPN6, STAT2, IL13RA1, IFNGR1, CCND1, IRF9, STAT1, OSMR, STAT6, SPRY1, CREBBP, PIK3R2, JAK1, PIAS3, PIK3CA, STAT3, CBLB, GRB2, SOS2",0.132532512140949,0.000869458712628891,FALSE +"proteomics","Log2FC","KEGG_LEISHMANIA_INFECTION",0.37967,1.04,0.366,2883,0.817,"ITGB2, PTGS2, MAPK12, MAPK13, MYD88, PTPN6, IFNGR1, STAT1, ITGA4, TRAF6, MARCKSL1, JAK1, MAPK3, NFKBIA, MAPK14, C3, MAPK1, IL1B",0.436518914605589,0.0877779434675845,FALSE +"proteomics","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.50535,1.43,0.0869,809,0.569,"CLDN18, CLDN4, CLDN7, RAC2, CDH5, ITGAL, ITGB2, CLDN3, F11R, CLDN6, CTNND1, ACTN3, CTNNA1, JAM2, MAPK12, CTNNA2, CTNNB1, PIK3CD, MAPK13",1.06098022355133,0.244887733604929,FALSE +"proteomics","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.6513,-1.99,0.0168,7847,0.247,"ALDH9A1, EHHADH, ALDH1B1, ALDH3A2, YOD1, ALDH2, ALDH7A1, NAA80",1.77469071827414,0.607303046740334,TRUE +"proteomics","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",-0.568,-1.68,0.0335,10332,0.494,"PLA2G6, CYP3A7",1.47495519296315,0.306273051076353,FALSE +"proteomics","Log2FC","KEGG_LONG_TERM_DEPRESSION",-0.22631,-0.656,0.934,9590,1,"GNAI1, ITPR1, PLCB2, GRM5, PLCB4, PLA2G6, PPP1R17",0.0296531237699066,0,FALSE +"proteomics","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.24302,0.69,0.87,2407,0.998,"EP300, PPP3R1, PPP3CA, PPP3CB, PPP3R2, KRAS, NRAS, RPS6KA1, CREBBP, RPS6KA6, PLCB1, RPS6KA2, HRAS, MAPK3, CAMK2D",0.0604807473813815,0.000869458712628891,FALSE +"proteomics","Log2FC","KEGG_LYSINE_DEGRADATION",-0.35898,-1.07,0.325,10138,0.63,"TMLHE, PIPOX, ALDH2, ALDH7A1, AADAT, BBOX1",0.488116639021126,0.200659450546418,FALSE +"proteomics","Log2FC","KEGG_LYSOSOME",0.25134,0.699,0.882,1651,1,"CTSE, CTSH, AP1M2, CTSS, ACP5, LAMP3, NEU1, NPC2, NAPSA, CTSA, SLC11A2, GM2A, AP1B1, AP1S1, FUCA1, SGSH",0.0545314148681803,0,FALSE +"proteomics","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",-0.30167,-0.88,0.566,9929,0.753,"TGFB3, DUSP16, MAPK8, FLNC, DDIT3, MKNK2, FGFR1, TGFB1, MAP2K5, PLA2G6, MAP2K6, MAPK11, MYC, NFKB2, TGFB2, ATF4, RELB, IL1A, CACNA2D2, DUSP4, CACNA2D1, MEF2C, FGF13, FGF2, RASGRP2, PDGFRA",0.247183568811729,0.123205023799299,FALSE +"proteomics","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.73187,-2.15,0,9747,0.311,"HNF1A, HNF4A, NEUROD1, GCK, MNX1, PAX6",Inf,0.507239610973163,FALSE +"proteomics","Log2FC","KEGG_MELANOGENESIS",0.30698,0.861,0.651,3523,0.994,"GNAO1, TYR, CTNNB1, WNT5B, EP300, LEF1, KRAS, NRAS, WNT11, DVL1, CREBBP, CREB3L2, CREB3L1, PLCB1, HRAS, MAPK3, CAMK2D, WNT5A, TCF7L1, MAPK1, GNAI2, DVL3, GNAI3, ADCY9, CAMK2B, PLCB3, ADCY5, CREB1, PRKCG",0.186419011431808,0.00261361560268669,FALSE +"proteomics","Log2FC","KEGG_MELANOMA",-0.43,-1.26,0.17,10540,0.554,"CDK6, FGF13, FGF2, PDGFRA",0.769551078621726,0.25649023527157,FALSE +"proteomics","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.42413,-1.25,0.176,10663,0.525,"AKR1C1, GSTM2, AKR1C3, AKR1C2, GSTA4, ALDH3A1, CYP3A7",0.75448733218585,0.279840696594043,FALSE +"proteomics","Log2FC","KEGG_MISMATCH_REPAIR",0.43847,1.25,0.173,4177,0.576,"PCNA, LIG1, MLH3, RFC5, POLD4, EXO1, RFC2, RFC3, RFC1, RPA3, POLD3, RFC4",0.761953896871205,0.239577516576788,FALSE +"proteomics","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.42655,1.18,0.232,2845,0.661,"VEGFA, VEGFC, PIK3CD, CAB39, PDPK1, RPS6KA1, PIK3R2, RPS6KA6, HIF1A, PIK3CA, RPS6KA2, EIF4EBP1, MAPK3, RHEB, RPS6KB2, RICTOR, RPS6KA3, MAPK1",0.6345120151091,0.17979854051436,FALSE +"proteomics","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.48135,1.35,0.129,2561,0.606,"RAC2, ITGAL, ITGB2, LCK, RAET1L, ULBP2, NFATC4, SH3BP2, ICAM2, PIK3CD, RAC3, PTPN6, PPP3R1, VAV1, LCP2, PPP3CA, VAV2, IFNGR1, PPP3CB, PPP3R2, KRAS, NRAS, PTK2B, ICAM1, NFATC1, PIK3R2, RAC1, PIK3CA, HRAS, MAPK3, VAV3, GRB2, NFATC3, NFATC2, SOS2",0.889410289700751,0.217527375833714,FALSE +"proteomics","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.21798,-0.634,0.909,8815,1,"TACR1, LEPR, F2R, P2RY11, CTSG, GRM5, PRSS1",0.0414361167780325,0,FALSE +"proteomics","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.31617,0.889,0.575,2672,0.954,"ARHGDIB, BCL2, TP73, PRKCD, ZNF274, MAPK12, PIK3CD, MAPK13, IRS1, GAB1, PDPK1, MAP3K5, TRAF6, KRAS, NRAS, RPS6KA4, MAP3K1, RPS6KA1, MAGED1, RHOA, PIK3R2, RPS6KA6, TP53, RAC1, NTRK2, PIK3CA, IKBKB, RPS6KA2, HRAS, MAPK3, CAMK2D, NFKBIA, GRB2, SOS2, FRS2, MAPK14, SORT1",0.24033215531037,0.0204516252959049,FALSE +"proteomics","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.48857,-1.4,0.108,9003,0.575,"NMNAT3, NAMPT, NNT, NT5C, CD38, BST1, NNMT",0.96657624451305,0.24033215531037,FALSE +"proteomics","Log2FC","KEGG_NITROGEN_METABOLISM",-0.39831,-1.16,0.232,9727,0.549,"CA14, CA2, CA12, CPS1, CA8",0.6345120151091,0.260427655549908,FALSE +"proteomics","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.43448,1.21,0.218,2883,0.628,"CASP5, CXCL1, MAPK12, TRIP6, MAPK13, CASP1, TRAF6, IL18, IKBKB, MAPK3, NAIP, NFKBIA, TAB3, MAPK14, CASP8, CCL13, MAPK1, IL1B",0.661543506395395,0.202040356262804,FALSE +"proteomics","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.71762,-2.09,0.00529,9253,0.215,"NHEJ1, PRKDC, RAD50, MRE11, POLL",2.27654432796481,0.667561540084395,TRUE +"proteomics","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.41063,1.16,0.254,2596,0.673,"RXRA, RXRG, TGFA, ERBB2, PIK3CD, EGFR, CDK4, PDPK1, CCND1, KRAS, NRAS, PIK3R2, TP53, PIK3CA, HRAS, MAPK3, GRB2, SOS2, CDKN2A",0.595166283380062,0.171984935776023,FALSE +"proteomics","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.34018,0.957,0.496,3178,0.942,"DTX3L, EP300, JAG1, NOTCH3, NCOR2, DVL1, CREBBP, DTX2, CTBP1, NUMB, HDAC1, MAML3, DVL3, RBPJ, JAG2",0.304518323509803,0.0259490972071227,FALSE +"proteomics","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.17811,-0.528,0.987,1956,0.992,"ERCC5, PCNA, RAD23B, LIG1, RFC5, POLD4, RFC2, RFC3, POLE, RFC1, RPA3, CUL4A, POLE4, POLD3, RFC4, RBX1, CETN2, POLE3, DDB1, MNAT1, POLD1, ERCC6, RAD23A, ERCC4, RPA2, POLE2, POLD2, RPA1, CDK7, GTF2H5, ERCC3, DDB2, CUL4B, GTF2H3, ERCC2, CCNH, GTF2H4, GTF2H1, GTF2H2, ERCC1, ERCC8, XPC, XPA",0.00568284733036327,0.00348832784582135,FALSE +"proteomics","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.47511,1.32,0.14,836,0.576,"MAN1C1, MGAT4A, ST6GAL1, B4GALT1, FUT8",0.853871964321762,0.239577516576788,FALSE +"proteomics","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",-0.37643,-1.06,0.323,9870,0.632,"CNGB1, PDE1C",0.490797477668897,0.199282921717615,FALSE +"proteomics","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.53605,-1.57,0.0608,8075,0.492,"MTHFD1L, ATIC, MTHFD2, MTHFS, MTFMT, TYMS, MTHFR, GART, ALDH1L1",1.21609642072727,0.30803489723264,FALSE +"proteomics","Log2FC","KEGG_OOCYTE_MEIOSIS",0.19709,0.561,0.989,3300,1,"MAPK12, PPP3R1, ANAPC11, PPP3CA, AR, AURKA, PPP3CB, PPP2R5E, CCNB1, PPP3R2, PPP2R5B, BUB1, RPS6KA1, RPS6KA6, RPS6KA2, MAPK3, CAMK2D, IGF1R, RPS6KA3, MAPK1, BTRC, YWHAB, ADCY9, PKMYT1, CAMK2B",0.0048037084028206,0,FALSE +"proteomics","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",-0.2091,-0.628,0.946,7256,1,"FUCA2, MAN2B1, HEXB, MAN2B2, AGA, MAN2C1, HEXA",0.0241088635982073,0,FALSE +"proteomics","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.46085,-1.35,0.139,7298,0.631,"NDUFV2, COX7C, NDUFS4, SDHB, NDUFB5, COX15, ATP6V1A, COX4I1, SDHC, COX6B1, COX6A1, NDUFV1, UQCRC1, ATP6V1B2, COX7A2, NDUFA6, NDUFC1, PPA1, ATP6V0A2, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, NDUFA2, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, NDUFA11, NDUFA3, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, ATP5MG, SDHD, NDUFS8, NDUFS2, ATP5F1C, ATP5F1B, ATP5PB, ATP5PD, NDUFB2, ATP5ME, ATP5MC2, COX11",0.856985199745905,0.199970640755866,FALSE +"proteomics","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.59998,1.68,0.0252,1847,0.884,"GCNT3, GALNT3, GALNT12, GALNT6, ST6GALNAC1, GALNT8, GALNT13, GALNT7, B4GALT5, GALNT2, GALNT15, GALNT5, C1GALT1C1, GALNT4, ST3GAL1",1.59859945921846,0.0535477349869269,FALSE +"proteomics","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.29693,0.837,0.678,1726,1,"TP73, SERPINB5, SESN3, THBS1, CHEK2, CDK4, CCND1, RCHY1, CCNB1, CDKN1A, EI24",0.168770306132937,0,FALSE +"proteomics","Log2FC","KEGG_PANCREATIC_CANCER",0.39919,1.12,0.285,2405,0.685,"RAC2, VEGFA, TGFA, ERBB2, VEGFC, PIK3CD, RAC3, EGFR, CDK4, RALB, CCND1, STAT1, KRAS, PIK3R2, TP53, JAK1, RAC1, PIK3CA, STAT3, IKBKB, MAPK3",0.54515513999149,0.164309428507574,FALSE +"proteomics","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.26633,0.737,0.814,2657,1,"BCAT2, PANK1, DPYD",0.0893755951107988,0,FALSE +"proteomics","Log2FC","KEGG_PARKINSONS_DISEASE",-0.47609,-1.4,0.101,7298,0.575,"NDUFV2, COX7C, NDUFS4, SDHB, NDUFB5, UBE2J2, COX4I1, SLC18A1, SDHC, COX6B1, COX6A1, CYCS, NDUFV1, UQCRC1, COX7A2, NDUFA6, NDUFC1, UBE2G2, UBE2G1, HTRA2, NDUFA7, NDUFA8, NDUFA4, NDUFS5, PARK7, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, SLC25A6, NDUFA2, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, VDAC1, NDUFA3, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, ATP5F1C, ATP5F1B, ATP5PB, SLC25A4, ATP5PD, NDUFB2, ATP5MC2, UCHL1",0.995678626217357,0.24033215531037,FALSE +"proteomics","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.24664,0.697,0.879,646,1,"LY96, CDH1, TUBA4A, CTNNB1",0.0560111249262281,0,FALSE +"proteomics","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.24197,0.68,0.884,2654,0.991,"RAC2, BCL2, CDH1, PTGS2, VEGFA, CTNNA1, LAMC2, LAMB3, RXRA, RXRG, TRAF4, CTNNA2, CTNNB1, TGFA, ERBB2, WNT5B, VEGFC, PIK3CD, RAC3, EP300, MECOM, RARA, RUNX1, ITGA2, LAMA3, LAMA4, NCOA4, EGFR, CKS1B, CDK4, RALB, SKP2, AR, LEF1, CCND1, STAT1, TRAF6, KRAS, NRAS, CDKN1A, ITGA3, WNT11, DVL1, FLT3, MAX, RHOA, MMP2, BCR, CREBBP, PIK3R2, TP53, JAK1, RAC1, PIAS3, HIF1A, MET, SLC2A1, PIK3CA, CTBP1, STAT3, IKBKB, HRAS, MAPK3, LAMB1, WNT5A, NFKBIA, CBLB, GRB2, IGF1R, SOS2, CDKN2A, TCF7L1, HDAC1, PAX8",0.0535477349869269,0.00392634551472468,FALSE +"proteomics","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.39564,1.09,0.314,6667,0.741,"DCXR, UGP2, XYLB, UGDH, CRYL1, UGT2B11, UGT2B4, RPE, GUSB, AKR1B1",0.503070351926785,0.130181792020672,FALSE +"proteomics","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.50211,1.39,0.115,829,0.594,"ALDOB, FBP1, ALDOC, FBP2",0.939302159646388,0.226213555018806,FALSE +"proteomics","Log2FC","KEGG_PEROXISOME",0.32858,0.937,0.497,2901,0.933,"FAR1, PXMP4, EPHX2, PEX13, MVK, ACSL4, ACOT8, ACAA1, AMACR, ACSL1, CAT, CRAT, ACOX1, SLC25A17, FAR2, SCP2, CROT, ACSL6, GSTK1, IDH2, ACOX3, ACSL5, PMVK, PEX7, NUDT12, ACSL3, ABCD3, IDH1, PXMP2",0.303643611266668,0.0301183562535,FALSE +"proteomics","Log2FC","KEGG_PHENYLALANINE_METABOLISM",-0.44236,-1.29,0.184,10509,0.551,"MAOB, NAA80, ALDH3A1",0.735182176990464,0.258848401148215,FALSE +"proteomics","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.26615,0.752,0.792,2260,1,"IMPA2, DGKA, INPP4B, PIK3CD, PIP4K2C, CDS1, DGKH, DGKB, PIK3R2, PLCB1, PIK3C2B, PIK3CA, PI4KA, PLCD1",0.101274818410506,0,FALSE +"proteomics","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.41459,-1.22,0.203,8765,0.519,"BLVRA, HMBS, PPOX, EARS2, BLVRB, HMOX1, ALAS1, UROD, UROS, FECH",0.692503962086787,0.284832642151542,FALSE +"proteomics","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.40642,1.15,0.247,1703,0.678,"CD36, PLTP, LPL, FADS2, FABP6, FABP2, RXRA, RXRG, SCD5, ACSL4, FABP3, APOC3, ACAA1, PDPK1, ACSL1, ACOX1, CPT2, SCP2, ACSL6, HMGCS2",0.607303046740334,0.168770306132937,FALSE +"proteomics","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.44792,1.26,0.171,1638,0.588,"CYP7B1, AMACR, SCP2",0.767003889607846,0.230622673923862,FALSE +"proteomics","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.32308,-0.967,0.487,9562,0.648,"RFX5, RFXAP, CD40, BLNK",0.312471038785366,0.188424994129407,FALSE +"proteomics","Log2FC","KEGG_PRION_DISEASES",-0.62081,-1.8,0.0296,10295,0.366,"C7, SOD1, C9, NCAM1, IL1A, NCAM2, EGR1",1.52870828894106,0.436518914605589,FALSE +"proteomics","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.25639,0.712,0.835,3263,1,"FZR1, MAPK12, PIK3CD, MAPK13, ANAPC11, CCNB1, KRAS, BUB1, CCNA2, RPS6KA1, PIK3R2, RPS6KA6, PIK3CA, RPS6KA2, MAPK3, IGF1R, MAPK14, RPS6KA3, MAPK1, GNAI2, GNAI3, CCNB3, ADCY9, PKMYT1",0.0783135245163979,0,FALSE +"proteomics","Log2FC","KEGG_PROPANOATE_METABOLISM",-0.26044,-0.786,0.737,10443,0.875,"ALDH2, ALDH7A1, ACSS3",0.132532512140949,0.0579919469776868,FALSE +"proteomics","Log2FC","KEGG_PROSTATE_CANCER",0.32384,0.909,0.546,2624,0.976,"BCL2, CTNNB1, TGFA, ERBB2, PIK3CD, EP300, EGFR, AR, LEF1, PDPK1, CCND1, KRAS, NRAS, CDKN1A, CREBBP, PDGFC, PIK3R2, CREB3L2, TP53, CREB3L1, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, GRB2, IGF1R, SOS2, TCF7L1",0.262807357295263,0.0105501823333082,FALSE +"proteomics","Log2FC","KEGG_PROTEASOME",0.2805,0.792,0.755,7310,0.995,"PSMB10, PSMB8, PSME2, PSME1, POMP, PSMB1, PSMB9, PSMA7, PSMA1, PSMA2, PSME3, PSMA8, PSMA3, PSMB2, PSMC6, PSMB3, PSMD7, PSME4, PSMA5, PSMB4, PSMA4, PSMD4, PSMD2, PSMB7, PSMD3, PSMD11, PSMC2, PSMC4, PSMC3, PSMC5, PSMF1, PSMD12, PSMD13, PSMA6, PSMC1, PSMB6, PSMD14, PSMD6, PSMD8, PSMD1, SEM1",0.122053048370812,0.00217691925427455,FALSE +"proteomics","Log2FC","KEGG_PROTEIN_EXPORT",-0.34994,-1.03,0.358,7823,0.643,"SEC61B, IMMP2L, SEC11C, SEC63, IMMP1L, SEC61A2",0.446116973356126,0.191789027075778,FALSE +"proteomics","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.28081,0.785,0.752,3930,0.997,"ATP1A2, GLUD2, AQP1, SLC38A3, ATP1A3, ATP1A4, ATP1A1, SLC9A3, PCK1, ATP1B1",0.123782159408358,0.00130484168834428,FALSE +"proteomics","Log2FC","KEGG_PURINE_METABOLISM",-0.26075,-0.762,0.777,7632,0.879,"PRIM2, PDE4D, POLA1, POLR3C, HPRT1, POLR2E, POLR3A, POLR3H, PDE8A, ENTPD4, GMPR2, POLA2, POLR2H, NUDT9, PNPT1, ATIC, NME2, ADCY3, ADCY8, PAPSS2, AK5, NUDT2, POLR3GL, GDA, POLR1E, GMPS, RRM2B, ADCY10, NPR2, GART, PFAS, NT5C, NME4, NUDT5, PDE3A, ADCY6, ENTPD1, PDE4A, NME1, NPR1, PDE1C, ENTPD8",0.109578981199086,0.0560111249262281,FALSE +"proteomics","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.20888,-0.608,0.945,7564,0.988,"POLR2A, AK3, PRIM2, DHODH, DCTD, POLA1, POLR3C, POLR2E, POLR3A, POLR3H, ENTPD4, POLA2, POLR2H, PNPT1, NME2, DTYMK, NUDT2, TYMS, POLR3GL, POLR1E, CAD, RRM2B, DUT, UCK2, NT5C, UMPS, NME4, TXNRD1, ENTPD1, CTPS1, NME1, ENTPD8",0.0245681914907371,0.00524305541237188,FALSE +"proteomics","Log2FC","KEGG_PYRUVATE_METABOLISM",-0.33889,-0.981,0.375,7380,0.663,"ACYP2, GRHPR, ACACA, PDHB, ALDH9A1, ME2, ALDH1B1, PDHA1, ACAT1, ALDH3A2, GLO1, PCK2, HAGH, ME3, ALDH2, ALDH7A1",0.425968732272281,0.178486471595227,FALSE +"proteomics","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.26341,0.736,0.815,1559,1,"ITGB6, RAC2, ITGAL, PAK5, PAK6, ITGB8, ITGB2, ACTN3, ITGB4, BAIAP2, SCIN, MYH14, PIK3CD, PIP4K2C, SLC9A1, RAC3, VAV1, GSN, ITGA2, ITGA11, EGFR, SSH3, VAV2, FGD3, ITGA4, KRAS, NRAS",0.0888423912600234,0,FALSE +"proteomics","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.43145,-1.26,0.171,7210,0.554,"PIK3R4, ATG4B, ULK1, ATG5, PIK3C3, GABARAPL1, ATG3, ATG7, ULK3, PRKAA2",0.767003889607846,0.25649023527157,FALSE +"proteomics","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.3892,1.08,0.34,2561,0.734,"PAK5, PAK6, VEGFA, TGFA, VEGFC, PIK3CD, EP300, GAB1, KRAS, NRAS, CREBBP, PIK3R2, RAC1, HIF1A, MET, SLC2A1, PIK3CA, HRAS, MAPK3, GRB2, SOS2",0.468521082957745,0.134303940083929,FALSE +"proteomics","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.32703,-0.983,0.431,9197,0.674,"NLN, AGT, CTSG, ACE2",0.365522729839268,0.17134010346468,FALSE +"proteomics","Log2FC","KEGG_RETINOL_METABOLISM",-0.40251,-1.17,0.241,10576,0.568,"ALDH1A2, ALDH1A1, CYP3A7",0.617982957425132,0.245651664288981,FALSE +"proteomics","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",0.46483,1.31,0.135,593,0.577,"ACP5, MTMR7, TYR",0.869666231504994,0.238824186844269,FALSE +"proteomics","Log2FC","KEGG_RIBOSOME",-0.54955,-1.66,0.0451,6763,0.457,"RPSA, RPS16, RPS26, MRPL13, RPL13, RPL11, RPS25, RPL37A, RPL35, RPS4X, RPL27, RPS21, RPS28, RPS27L, RPS15A, RPS2, RPL14, FAU, RPL23, RPL7A, RPL29, RPS29, RPL21, RPL5, RPL34, RPL22, RPS9, RPS3, RPS18, RPL17, RPL15, RPL8, RPL18A, RPS3A, RPS12, RPL28, RPS11, RPL36, RPS17, RPL36A, RPL36AL, RPL3, RPL13A, RPL32, RPL26, RPL27A, RPS8, RPL10A, RPS7, RPS24, RPL7, RPS23, RPL31, RPL9, RPS13, RPL35A, RPL18, RPL19, RPL24, RSL24D1, RPL4, RPS20, RPL6, RPL38, RPS6, RPL37, RPL26L1, RPS4Y1",1.34582345812204,0.34008379993015,FALSE +"proteomics","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.21434,0.597,0.964,1713,1,"ISG15, MAPK12, MAPK13, CASP10, DDX58, DHX58, TRAF6, MAP3K1",0.0159229660971692,0,FALSE +"proteomics","Log2FC","KEGG_RNA_DEGRADATION",-0.43669,-1.29,0.158,7190,0.551,"TTC37, EXOSC3, EXOSC2, EXOSC4, DIS3, EXOSC9, EXOSC5, EXOSC7, LSM2, PNPT1, EXOSC10, EXOSC8, LSM1, EXOSC1, MTREX, ENO3, HSPD1, HSPA9, PARN, TENT4A, DCP2, MPHOSPH6, DCPS, DCP1B",0.801342913045577,0.258848401148215,FALSE +"proteomics","Log2FC","KEGG_RNA_POLYMERASE",-0.42301,-1.24,0.186,5911,0.523,"POLR3F, POLR1B, POLR2D, POLR3K, POLR2B, POLR2G, POLR2C, POLR1A, POLR3B, POLR1C, POLR1D, POLR3D, POLR2L, POLR2I, POLR2A, POLR3C, POLR2E, POLR3A, POLR3H, POLR2H, POLR3GL, POLR1E",0.730487055782084,0.281498311132726,FALSE +"proteomics","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",0.26182,0.733,0.814,2085,1,"GGT5, CTH, METTL6, GGT7",0.0893755951107988,0,FALSE +"proteomics","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.31583,0.89,0.556,2488,0.966,"BCL2, PTGS2, LAMC2, LAMB3, RXRA, RXRG, TRAF4, PIK3CD, ITGA2, LAMA3, LAMA4, CKS1B, CDK4, SKP2, CCND1, TRAF6, ITGA3, MAX, PIK3R2, TP53, PIAS3, PIK3CA, IKBKB, LAMB1, NFKBIA",0.254925208417942,0.0150228735845067,FALSE +"proteomics","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.25505,0.714,0.848,3653,1,"VAMP8, VAMP4, TSNARE1, BET1L, STX17, SNAP47, STX3, GOSR1, STX10, SNAP29, STX16, STX18, STX12, STX6, VTI1B, SNAP23",0.0716041477432862,0,FALSE +"proteomics","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",0.29469,0.833,0.675,2465,0.992,"CERK, NEU1, UGT8, SGPP2, SPTLC2, GALC, PLPP3, DEGS1, SPTLC1",0.170696227168975,0.00348832784582135,FALSE +"proteomics","Log2FC","KEGG_SPLICEOSOME",-0.44795,-1.31,0.131,6622,0.6,"BCAS2, SNRPD1, SNRPD2, USP39, SF3A2, PRPF6, LSM3, THOC2, SNW1, SRSF6, SYF2, PQBP1, HNRNPA1, U2AF2, ACIN1, SNRPB2, MAGOHB, SRSF7, PRPF40A, HSPA8, HNRNPC, SNRPC, PPIL1, THOC1, RBM25, CTNNBL1, ZMAT2, SNRNP200, PRPF38B, HNRNPK, PRPF31, PPIH, HNRNPM, EIF4A3, DDX46, DDX39B, HNRNPA3, SF3A3, SRSF9, U2AF1, SRSF1, DDX23, SRSF4, SNRPA, SNRNP27, EFTUD2, SRSF8, PRPF38A, TRA2B, SNRPD3, DHX16, PPIE, SNRPF, SRSF3, LSM2, ALYREF, RBM8A, RBM17, SRSF2, SF3B4, TCERG1, RBMX, PRPF8, CDC40, U2SURP, SMNDC1, WBP11, RBM22, SNRNP40, SLU7, PRPF18, TRA2A, BUD31, SNU13, TXNL4A, CHERP, HNRNPU",0.882728704344236,0.221848749616356,FALSE +"proteomics","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.44846,1.28,0.156,2989,0.565,"HK1, SI, PYGB, PGM1, HK2, GAA, PGM2, AGL, PYGL, GYS1, UGP2, MGAM, PGM2L1",0.806875401645538,0.247951552180562,FALSE +"proteomics","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.72045,2.03,0.00909,2290,0.516,"DHCR24, MSMO1, FDFT1, CYP27B1, DHCR7, SC5D, SQLE, NSDHL, HSD17B7, CYP51A1, LSS",2.04143611677803,0.287350298372789,FALSE +"proteomics","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.44063,-1.31,0.157,10468,0.6,"AKR1D1, CYP21A2, AKR1C1, AKR1C3, AKR1C2, CYP3A7",0.804100347590766,0.221848749616356,FALSE +"proteomics","Log2FC","KEGG_SULFUR_METABOLISM",0.57977,1.66,0.0375,1903,0.774,"SULT2B1, SULT1A3, CHST12",1.42596873227228,0.111259039317107,FALSE +"proteomics","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.47545,-1.41,0.108,9770,0.649,"CTSG, C7, CD40, C9, C1S",0.96657624451305,0.187755303199631,FALSE +"proteomics","Log2FC","KEGG_TASTE_TRANSDUCTION",0.39951,1.14,0.282,89,0.685,"SCNN1A",0.549750891680639,0.164309428507574,FALSE +"proteomics","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.5101,1.44,0.0767,2497,0.579,"HMGCS1, MVK, HMGCR, HMGCS2, PDSS2, PMVK, FDPS",1.11520463605102,0.237321436272564,FALSE +"proteomics","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.42677,-1.25,0.201,9929,0.525,"TGFB3, THBS4, THBS3, TGFB1, SMAD2, BMPR2, MYC, INHBA, FST, ACVR2A, TGFB2, BMPR1A, INHBE",0.696803942579511,0.279840696594043,FALSE +"proteomics","Log2FC","KEGG_THYROID_CANCER",0.56509,1.61,0.039,2845,0.611,"CDH1, RXRA, RXRG, CTNNB1, NCOA4, LEF1, CCND1, KRAS, NRAS, TP53, HRAS, MAPK3, TCF7L1, PAX8, MAPK1",1.4089353929735,0.213958789757446,FALSE +"proteomics","Log2FC","KEGG_TIGHT_JUNCTION",0.5679,1.6,0.0446,1947,0.423,"CLDN18, CLDN4, CLDN7, CRB3, MYH7, PRKCH, EPB41L1, CGN, CLDN3, F11R, CLDN6, TJP3, ACTN3, CTNNA1, PRKCD, JAM2, PATJ, CTNNA2, CTNNB1, MYH14, MYH7B, TJP2, LLGL2, CDK4, MAGI3, PRKCQ, CASK, KRAS, NRAS, PRKCZ, PRKCI, CTTN, PARD6G, YES1, CLDN11, EXOC3, MYL9, RHOA, EXOC4",1.35066514128786,0.373659632624958,FALSE +"proteomics","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.24732,0.692,0.9,2883,1,"LY96, IRF5, MAPK12, PIK3CD, MAPK13, MYD88, STAT1, TRAF6, PIK3R2, RAC1, PIK3CA, IKBKB, MAPK3, NFKBIA, IKBKE, MAPK14, CASP8, MAPK1, IL1B",0.0457574905606751,0,FALSE +"proteomics","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",-0.38666,-1.13,0.255,10040,0.537,"WARS2, ALDH2, MAOB, ALDH7A1, AADAT, KYNU",0.593459819566045,0.270025714300444,FALSE +"proteomics","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",-0.31589,-0.917,0.5,10063,0.72,"MAPK8, GCK, SOCS2, SOCS4",0.301029995663981,0.142667503568732,FALSE +"proteomics","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",0.44767,1.25,0.176,1073,0.576,"CPE, PTPRN2, ICA1",0.75448733218585,0.239577516576788,FALSE +"proteomics","Log2FC","KEGG_TYROSINE_METABOLISM",0.29251,0.822,0.677,2304,0.979,"ADH4, ADH7, TYR, HGD, ALDH1A3, ALDH3B1, METTL6, ADH1C, COMT, TAT, MIF",0.169411331314856,0.00921730819686218,FALSE +"proteomics","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.50774,1.44,0.084,2664,0.579,"PAK5, PAK6, LCK, CARD11, MAPK12, NFATC4, PIK3CD, MAPK13, PTPN6, PPP3R1, VAV1, LCP2, CDK4, PPP3CA, VAV2, PDPK1, PPP3CB, PPP3R2, PRKCQ, KRAS, NRAS, RHOA, NFATC1, PTPRC, PIK3R2, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, CBLB, VAV3, GRB2, NFATC3, NFATC2, SOS2, TEC, MAPK14",1.07572071393812,0.237321436272564,FALSE +"proteomics","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.18021,0.513,0.997,2223,1,"FZR1, UBE2C, UBA7, UBE2E3, ANAPC11, TRIM37, SKP2, RCHY1, MGRN1, UBOX5, UBE2L6, KEAP1, TRAF6, MAP3K1, UBE2O, 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+
+
+ + + + diff --git a/Examples/Fig5/DMEA/DMEA_mean_results.csv b/Examples/Fig5/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..8547d6a --- /dev/null +++ b/Examples/Fig5/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"PLK inhibitor",1.80333333333333,0.410406302745625,0.000125094496019932,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, proteomics",0.0103828431696544 +"MDM inhibitor",1.63333333333333,0.430155010819743,0.00240185384072756,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.0591170525636295 +"sterol demethylase inhibitor",1.57,0.383536178215302,0.0714892001869014,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.296680180775641 +"acetylcholine receptor agonist",1.46666666666667,0.32316146634977,0.0176719604230495,"transcriptomics, proteomics, metabolomics",3,0,"",0.133342974101191 +"serotonin receptor agonist",1.33333333333333,0.377403409276246,0.0448305100843667,"transcriptomics, proteomics, metabolomics",3,0,"",0.237996229004962 +"ATPase inhibitor",1.32533333333333,0.525761669707229,0.0136003308599986,"transcriptomics, proteomics, metabolomics",3,1,"proteomics",0.125425273486654 +"DNA inhibitor",1.31,0.0721110255092797,0.102251409257752,"transcriptomics, proteomics, metabolomics",3,0,"",0.368994216017104 +"glucocorticoid receptor agonist",1.28666666666667,0.436157463920238,0.0358107941875691,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.228638147505249 +"tubulin polymerization inhibitor",1.197,0.322594172297021,0.1721661869189,"transcriptomics, proteomics, metabolomics",3,0,"",0.522719237289947 +"Aurora kinase inhibitor",1.19333333333333,0.183393929379719,0.189305750862537,"transcriptomics, proteomics, metabolomics",3,0,"",0.523745910719686 +"progesterone receptor agonist",1.19333333333333,0.153079500042734,0.221191162691551,"transcriptomics, proteomics, metabolomics",3,0,"",0.549711490227961 +"growth factor receptor inhibitor",1.16766666666667,0.31679067747226,0.221277719413408,"transcriptomics, proteomics, metabolomics",3,0,"",0.549711490227961 +"estrogen receptor agonist",1.12333333333333,0.204042479237372,0.303384496583465,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097 +"opioid receptor agonist",1.05466666666667,0.325062045359549,0.429045558690266,"transcriptomics, proteomics, metabolomics",3,0,"",0.684822718678694 +"dopamine receptor antagonist",1.01833333333333,0.409590445852114,0.381173921200214,"transcriptomics, proteomics, metabolomics",3,0,"",0.673136924672718 +"estrogen receptor antagonist",1.005,0.234467481753867,0.484273487044021,"transcriptomics, proteomics, metabolomics",3,0,"",0.71776248972596 +"serotonin receptor antagonist",1.00133333333333,0.207164990607326,0.52426304021773,"transcriptomics, proteomics, metabolomics",3,0,"",0.737522582001213 +"protein synthesis inhibitor",0.993,0.319995312465667,0.477995068875388,"transcriptomics, proteomics, metabolomics",3,0,"",0.71776248972596 +"mTOR inhibitor",0.895333333333333,0.124444097221738,0.743893978929366,"transcriptomics, proteomics, metabolomics",3,0,"",0.851338029910444 +"antioxidant",0.882666666666667,0.15007109426313,0.748767182933282,"transcriptomics, proteomics, metabolomics",3,0,"",0.851338029910444 +"androgen receptor antagonist",0.819333333333333,1.23770809698141,0.0826639540891386,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.326719437590405 +"PI3K inhibitor",0.720666666666667,0.23715887782947,0.923930343272636,"transcriptomics, proteomics, metabolomics",3,0,"",0.95857773114536 +"PARP inhibitor",0.704,1.13903819075569,0.232218095090246,"transcriptomics, proteomics, metabolomics",3,0,"",0.550688625499727 +"HCV inhibitor",0.59,1.77738572065829,0.0104616887246457,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.125425273486654 +"HMGCR inhibitor",0.573333333333333,1.55165503038959,0.0309329853363614,"transcriptomics, proteomics, metabolomics",3,0,"",0.2139531485765 +"CC chemokine receptor antagonist",0.524,1.29214859826569,0.225183020093382,"transcriptomics, proteomics, metabolomics",3,0,"",0.549711490227961 +"JAK inhibitor",0.515333333333333,1.08213923934646,0.512415532783372,"transcriptomics, proteomics, metabolomics",3,0,"",0.737522582001213 +"DNA polymerase inhibitor",0.47,0.953939201416946,0.703342416444445,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985 +"FGFR inhibitor",0.463333333333333,1.36621130625293,0.215405789781722,"transcriptomics, proteomics, metabolomics",3,0,"",0.549711490227961 +"bacterial DNA gyrase inhibitor",0.454666666666667,0.969686719169306,0.703294635524819,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985 +"PPAR receptor agonist",0.427,1.62258343391026,0.0458787911334866,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.237996229004962 +"FLT3 inhibitor",0.419,1.0417518898471,0.665197417567066,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985 +"bacterial 50S ribosomal subunit inhibitor",0.407333333333333,1.31979594382364,0.273620253675792,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097 +"calcium channel blocker",0.377333333333333,0.939872509084787,0.784684981034233,"transcriptomics, proteomics, metabolomics",3,0,"",0.868384712344551 +"PDGFR tyrosine kinase receptor inhibitor",0.37,1.48798521498031,0.133385720980026,"transcriptomics, proteomics, metabolomics",3,0,"",0.461292285055922 +"adrenergic receptor antagonist",0.369,0.769968181160754,0.943562342962668,"transcriptomics, proteomics, metabolomics",3,0,"",0.965074520824202 +"microtubule inhibitor",0.345,1.0669812556929,0.678275859990291,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985 +"NFkB pathway inhibitor",0.342,0.936131935145896,0.827779861636799,"transcriptomics, proteomics, metabolomics",3,0,"",0.892282188517589 +"bromodomain inhibitor",0.316666666666667,1.35078989237162,0.303831806224957,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097 +"topoisomerase inhibitor",0.266666666666667,1.46083309564554,0.165057639383912,"transcriptomics, proteomics, metabolomics",3,0,"",0.522719237289947 +"thymidylate synthase inhibitor",0.258,1.32469317202136,0.358871060838437,"transcriptomics, proteomics, metabolomics",3,0,"",0.648140658366191 +"retinoid receptor agonist",0.223333333333333,1.16336766902529,0.56211990806605,"transcriptomics, proteomics, metabolomics",3,0,"",0.777599206158036 +"ribonucleotide reductase inhibitor",0.184666666666667,1.26390875198067,0.424780641517515,"transcriptomics, proteomics, metabolomics",3,0,"",0.684822718678694 +"KIT inhibitor",0.176,1.49896897899856,0.180651456941812,"transcriptomics, proteomics, metabolomics",3,0,"",0.522719237289947 +"BCL inhibitor",0.164666666666667,1.10480103789476,0.68279660651095,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985 +"potassium channel blocker",0.133666666666667,1.11756893896231,0.687244030386695,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985 +"VEGFR inhibitor",0.123,1.35687029593841,0.308355862013669,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097 +"p38 MAPK inhibitor",-0.0913333333333333,1.33512745958329,0.40172387179447,"transcriptomics, proteomics, metabolomics",3,0,"",0.684822718678694 +"benzodiazepine receptor agonist",-0.151,1.02284065230123,0.822553610958305,"transcriptomics, proteomics, metabolomics",3,0,"",0.892282188517589 +"protein tyrosine kinase inhibitor",-0.284666666666667,1.00706024315,0.782497037222137,"transcriptomics, proteomics, metabolomics",3,0,"",0.868384712344551 +"tyrosine kinase inhibitor",-0.292333333333333,1.17883685611425,0.524233517323791,"transcriptomics, proteomics, metabolomics",3,0,"",0.737522582001213 +"DNA alkylating agent",-0.324666666666667,1.10597573813051,0.640493409764762,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985 +"cyclooxygenase inhibitor",-0.333,0.758553887340906,0.958055663326781,"transcriptomics, proteomics, metabolomics",3,0,"",0.965074520824202 +"DNA synthesis inhibitor",-0.341333333333333,0.762239682339704,0.965074520824202,"transcriptomics, proteomics, metabolomics",3,0,"",0.965074520824202 +"histamine receptor antagonist",-0.344666666666667,1.23939716529179,0.413221228344381,"transcriptomics, proteomics, metabolomics",3,0,"",0.684822718678694 +"RET tyrosine kinase inhibitor",-0.35,1.85259277770372,0.0123562055061721,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.125425273486654 +"CDK inhibitor",-0.375666666666667,0.82054270658713,0.879743301655512,"transcriptomics, proteomics, metabolomics",3,0,"",0.936137103043686 +"TGF beta receptor inhibitor",-0.437333333333333,1.24362950002536,0.359210485359576,"transcriptomics, proteomics, metabolomics",3,0,"",0.648140658366191 +"phosphatase inhibitor",-0.443,1.01514481725515,0.659224725778365,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985 +"glutamate receptor antagonist",-0.500333333333333,1.26089663863987,0.306163869191785,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097 +"src inhibitor",-0.507333333333333,1.15981435296056,0.417488106342018,"transcriptomics, proteomics, metabolomics",3,0,"",0.684822718678694 +"Abl kinase inhibitor",-0.51,1.24554365640069,0.336985272298288,"transcriptomics, proteomics, metabolomics",3,0,"",0.635676763653589 +"AKT inhibitor",-0.516,0.916377651407977,0.698125717587431,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985 +"acetylcholine receptor antagonist",-0.571666666666667,1.03077850837769,0.477769778721304,"transcriptomics, proteomics, metabolomics",3,0,"",0.71776248972596 +"Bcr.Abl kinase inhibitor",-0.631666666666667,1.27101311296671,0.153374994382888,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.509204981351187 +"RAF inhibitor",-0.650666666666667,1.43419710407368,0.0691298987454567,"transcriptomics, proteomics, metabolomics",3,0,"",0.296680180775641 +"DNA methyltransferase inhibitor",-0.666666666666667,1.42619540503163,0.068753694326179,"transcriptomics, proteomics, metabolomics",3,0,"",0.296680180775641 +"adrenergic receptor agonist",-0.699,0.26481880597873,0.922539579505745,"transcriptomics, proteomics, metabolomics",3,0,"",0.95857773114536 +"HSP inhibitor",-0.805333333333333,0.475247654737331,0.715114405728945,"transcriptomics, proteomics, metabolomics",3,0,"",0.83597881233102 +"adenosine receptor antagonist",-0.842333333333333,1.54679873717731,0.0109167241558126,"transcriptomics, proteomics, metabolomics",3,0,"",0.125425273486654 +"cytochrome P450 inhibitor",-0.903,0.281607883412379,0.676593609045045,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985 +"sodium channel blocker",-0.956,0.410302327558594,0.47639547719143,"transcriptomics, proteomics, metabolomics",3,0,"",0.71776248972596 +"MEK inhibitor",-1.07833333333333,0.363034892721531,0.310694336047846,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097 +"AP inhibitor",-1.112,0.272088220987238,0.295542333019956,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097 +"ALK tyrosine kinase receptor inhibitor",-1.13666666666667,0.249866631092135,0.278711430888661,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097 +"glycogen synthase kinase inhibitor",-1.19166666666667,0.325051278005999,0.18263684194468,"transcriptomics, proteomics, metabolomics",3,0,"",0.522719237289947 +"vitamin D receptor agonist",-1.21766666666667,0.514525347610138,0.092438873796934,"transcriptomics, proteomics, metabolomics",3,0,"",0.348746660233888 +"MET inhibitor",-1.278,0.553328112425169,0.0679952828971801,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.296680180775641 +"phosphodiesterase inhibitor",-1.42333333333333,0.184481254693623,0.0436101520317822,"transcriptomics, proteomics, metabolomics",3,0,"",0.237996229004962 +"EGFR inhibitor",-1.50366666666667,0.587341751736869,0.0093541182753819,"transcriptomics, proteomics, metabolomics",3,1,"proteomics",0.125425273486654 +"HDAC inhibitor",-1.52333333333333,0.153731367434669,0.0152273870907784,"transcriptomics, proteomics, metabolomics",3,0,"",0.126387312853461 +"proteasome inhibitor",-1.68333333333333,0.0378593889720019,0.00284901458137974,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.0591170525636295 +"CHK inhibitor",-1.73333333333333,0.198578280114753,0.00199673170195349,"transcriptomics, proteomics, metabolomics",3,0,"",0.0591170525636295 diff --git a/Examples/Fig5/DMEA/DMEA_results.csv b/Examples/Fig5/DMEA/DMEA_results.csv new file mode 100644 index 0000000..7c015e9 --- /dev/null +++ b/Examples/Fig5/DMEA/DMEA_results.csv @@ -0,0 +1,250 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"transcriptomics","Pearson.est","EGFR inhibitor",-0.65533,-1.71,0.0258,1232,0.333,"GW.583340, BIBX.1382, lapatinib, tucatinib, tyrphostin.AG.1478, rociletinib, TAK.285, BIBU.1361, neratinib, XL.647, BMS.690514, PD.168393, PD.153035, ARRY.334543, icotinib, WZ8040, dacomitinib, osimertinib, poziotinib, erlotinib, afatinib, AZD8931, pelitinib, canertinib, gefitinib",1.58838029403677,0.47755576649368,FALSE +"transcriptomics","Pearson.est","Abl kinase inhibitor",0.32026,0.813,0.684,326,0.753,"GZD824, KW.2449, ponatinib, nilotinib, flumatinib",0.164943898279884,0.123205023799299,FALSE +"transcriptomics","Pearson.est","acetylcholine receptor agonist",0.68226,1.71,0.0257,320,0.378,"oxiracetam, pilocarpine, tremorine, xanomeline",1.59006687666871,0.422508200162775,FALSE +"transcriptomics","Pearson.est","acetylcholine receptor antagonist",-0.5322,-1.39,0.129,1021,0.508,"dicycloverine, darifenacin, diphemanil",0.889410289700751,0.294136287716081,FALSE +"transcriptomics","Pearson.est","adenosine receptor antagonist",-0.68287,-1.78,0.0229,1442,0.331,"MRS.1220, CGS.15943",1.64016451766011,0.480172006224281,FALSE +"transcriptomics","Pearson.est","adrenergic receptor agonist",-0.16807,-0.442,0.993,1390,0.993,"A61603",0.00305075150461883,0.00305075150461883,FALSE +"transcriptomics","Pearson.est","adrenergic receptor antagonist",-0.19743,-0.502,0.975,1195,1,"metoprolol, atenolol...., RS.17053, pindolol",0.0109953843014632,0,FALSE +"transcriptomics","Pearson.est","AKT inhibitor",-0.40618,-1.06,0.397,1036,0.744,"uprosertib, MK.2206, AZD5363, GDC.0068, CCT128930, A.674563, triciribine, GSK2110183",0.401209493236885,0.128427064454121,FALSE +"transcriptomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.35397,-0.92,0.519,1158,0.839,"CEP.37440, GW.788388, lorlatinib, NVP.TAE684, AP26113",0.284832642151542,0.0762380391712997,FALSE +"transcriptomics","Pearson.est","androgen receptor antagonist",0.51325,1.33,0.156,403,0.74,"RU.58841, bicalutamide, nilutamide",0.806875401645538,0.130768280269024,FALSE +"transcriptomics","Pearson.est","antioxidant",0.35423,0.888,0.563,190,0.674,"mesna, trolox",0.249491605148654,0.17134010346468,FALSE +"transcriptomics","Pearson.est","AP inhibitor",-0.43104,-1.12,0.296,968,0.728,"LCL.161, embelin, GDC.0152, tanshinone.i, birinapant",0.528708288941061,0.137868620686963,FALSE +"transcriptomics","Pearson.est","ATPase inhibitor",0.38535,0.976,0.468,409,0.687,"evodiamine, ouabain, omeprazole, oligomycin.a, digitoxigenin, digitoxin",0.329754146925876,0.16304326294045,FALSE +"transcriptomics","Pearson.est","Aurora kinase inhibitor",0.39912,1.05,0.39,400,0.661,"ENMD.2076, GSK1070916, PHA.680632, KW.2449, AMG900, barasertib, CCT137690, danusertib, AT.9283",0.408935392973501,0.17979854051436,FALSE +"transcriptomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.57175,1.47,0.0938,280,0.74,"valnemulin, radezolid, azalomycin.b",1.02779716162094,0.130768280269024,FALSE +"transcriptomics","Pearson.est","bacterial DNA gyrase inhibitor",0.45254,1.17,0.28,289,0.647,"novobiocin, nadifloxacin, norfloxacin, finafloxacin",0.552841968657781,0.1890957193313,FALSE +"transcriptomics","Pearson.est","BCL inhibitor",0.42122,1.06,0.383,283,0.69,"venetoclax, TW.37, navitoclax",0.416801226031377,0.161150909262745,FALSE +"transcriptomics","Pearson.est","Bcr.Abl kinase inhibitor",0.28362,0.734,0.787,326,0.805,"GZD824, ponatinib, nilotinib, flumatinib",0.104025267640935,0.0942041196321315,FALSE +"transcriptomics","Pearson.est","benzodiazepine receptor agonist",-0.28516,-0.73,0.754,975,0.895,"CGS.20625, nefiracetam, bentazepam, indiplon, temazepam, lorazepam, gamma.aminobutyric.acid",0.122628654130226,0.048176964684088,FALSE +"transcriptomics","Pearson.est","bromodomain inhibitor",0.46718,1.18,0.268,387,0.656,"I.BET.762, PFI.1, bromosporine",0.571865205971211,0.18309616062434,FALSE +"transcriptomics","Pearson.est","calcium channel blocker",0.44995,1.15,0.276,224,0.605,"carboxyamidotriazole, cinnarazine, efonidipine.monoethanolate",0.559090917934782,0.218244625347531,FALSE +"transcriptomics","Pearson.est","CC chemokine receptor antagonist",0.49081,1.26,0.198,515,0.66,"RS.504393, UNBS.5162, PF.04136309, ZK811752, SB.225002",0.703334809738469,0.180456064458131,FALSE +"transcriptomics","Pearson.est","CDK inhibitor",0.20715,0.534,0.974,257,0.963,"PHA.848125, BMS.265246, ribociclib, R547, indisulam",0.0114410431213845,0.0163737128754655,FALSE +"transcriptomics","Pearson.est","CHK inhibitor",-0.69447,-1.8,0.0199,1067,0.574,"LY2603618, AZD7762, SCH.900776, LY2606368, CHIR.124",1.70114692359029,0.241088107602027,FALSE +"transcriptomics","Pearson.est","cyclooxygenase inhibitor",-0.36632,-0.935,0.512,1319,0.857,"tryptanthrin, phenylbutazone, pterostilbene, FR.122047, FK.3311, naproxen",0.290730039024169,0.0670191780768018,FALSE +"transcriptomics","Pearson.est","cytochrome P450 inhibitor",-0.35354,-0.912,0.547,1221,0.813,"itraconazole, morin",0.262012673666569,0.0899094544059319,FALSE +"transcriptomics","Pearson.est","DNA alkylating agent",0.36203,0.927,0.52,144,0.678,"carboplatin, temozolomide, carmustine, cyclophosphamide",0.283996656365201,0.168770306132937,FALSE +"transcriptomics","Pearson.est","DNA inhibitor",0.51362,1.29,0.186,469,0.728,"valrubicin, carboplatin, carmustine, teroxirone, tirapazamine, mechlorethamine, pibenzimol, bendamustine, sangivamycin, metronidazole, nimorazole, oxaliplatin",0.730487055782084,0.137868620686963,FALSE +"transcriptomics","Pearson.est","DNA methyltransferase inhibitor",0.38659,0.98,0.45,163,0.7,"decitabine, disulfiram",0.346787486224656,0.154901959985743,FALSE +"transcriptomics","Pearson.est","DNA polymerase inhibitor",0.38116,0.97,0.461,270,0.678,"trifluridine, idoxuridine, foscarnet",0.336299074610352,0.168770306132937,FALSE +"transcriptomics","Pearson.est","DNA synthesis inhibitor",-0.29226,-0.748,0.76,1419,0.942,"estramustine.phosphate, altretamine",0.119186407719209,0.0259490972071227,FALSE +"transcriptomics","Pearson.est","dopamine receptor antagonist",0.3723,0.944,0.472,88,0.704,"thioproperazine, paliperidone, raclopride",0.326058001365912,0.152427340857888,FALSE +"transcriptomics","Pearson.est","estrogen receptor agonist",0.5063,1.3,0.181,244,0.759,"ethinyl.estradiol, estrone, levonorgestrel",0.742321425130815,0.11975822410452,FALSE +"transcriptomics","Pearson.est","estrogen receptor antagonist",0.29531,0.755,0.741,527,0.807,"danazol, clomifene, tamoxifen",0.130181792020672,0.0931264652779296,FALSE +"transcriptomics","Pearson.est","FGFR inhibitor",0.51738,1.35,0.157,97,0.749,"regorafenib, dovitinib, nintedanib",0.804100347590766,0.125518182300534,FALSE +"transcriptomics","Pearson.est","FLT3 inhibitor",0.50275,1.28,0.203,272,0.659,"sorafenib, dovitinib, TG.101348, ENMD.2076, KW.2449, ponatinib, tyrphostin.AG.1296",0.692503962086787,0.18111458540599,FALSE +"transcriptomics","Pearson.est","glucocorticoid receptor agonist",0.41693,1.05,0.382,612,0.661,"fluticasone.propionate, triamcinolone, halobetasol.propionate, desonide, dexamethasone.acetate, prednisolone.hemisuccinate, beclomethasone.dipropionate, rimexolone, prednisolone, ciclesonide, difluprednate, methylprednisolone, fludroxycortide, halcinonide, prednisolone.acetate, fluocinolone.acetonide",0.417936637088291,0.17979854051436,FALSE +"transcriptomics","Pearson.est","glutamate receptor antagonist",-0.40723,-1.03,0.393,1041,0.756,"CPP, ACDPP, SIB.1757, JNJ.16259685, LY456236, kynurenic.acid",0.405607449624573,0.121478204498793,FALSE +"transcriptomics","Pearson.est","glycogen synthase kinase inhibitor",-0.4128,-1.07,0.36,1365,0.776,"indirubin, GSK.3.inhibitor.IX",0.443697499232713,0.110138278741812,FALSE +"transcriptomics","Pearson.est","growth factor receptor inhibitor",0.38081,0.943,0.489,39,0.687,"PHA.848125",0.31069114087638,0.16304326294045,FALSE +"transcriptomics","Pearson.est","HCV inhibitor",0.59647,1.53,0.0789,133,0.799,"narlaprevir, mericitabine",1.10292299679058,0.0974532206860086,FALSE +"transcriptomics","Pearson.est","HDAC inhibitor",-0.64554,-1.7,0.0287,1274,0.263,"PCI.24781, M.344, panobinostat, romidepsin, tacedinaline, SB.939, JNJ.26481585, mocetinostat, nexturastat.a",1.54211810326601,0.580044251510242,FALSE +"transcriptomics","Pearson.est","histamine receptor antagonist",-0.29307,-0.764,0.737,1131,0.955,"BF2.649, astemizole, lafutidine, famotidine, chloropyramine",0.132532512140949,0.0199966284162537,FALSE +"transcriptomics","Pearson.est","HMGCR inhibitor",0.68253,1.73,0.0143,284,0.445,"fluvastatin, pitavastatin, mevastatin, atorvastatin, lovastatin",1.84466396253494,0.351639989019068,FALSE +"transcriptomics","Pearson.est","HSP inhibitor",-0.22397,-0.591,0.92,1415,0.99,"KW.2478",0.0362121726544447,0.00436480540245009,FALSE +"transcriptomics","Pearson.est","JAK inhibitor",0.45899,1.16,0.287,183,0.612,"AZD1480, TG.101348, WHI.P154, AZ960, baricitinib, filgotinib",0.542118103266008,0.213248577854439,FALSE +"transcriptomics","Pearson.est","KIT inhibitor",0.47392,1.23,0.237,184,0.649,"sorafenib, regorafenib, masitinib, OSI.930, pazopanib",0.625251653989896,0.187755303199631,FALSE +"transcriptomics","Pearson.est","MDM inhibitor",0.5324,1.38,0.144,57,0.819,"idasanutlin, nutlin.3",0.84163750790475,0.0867160982395816,FALSE +"transcriptomics","Pearson.est","MEK inhibitor",-0.36084,-0.941,0.492,1384,0.894,"PD.98059, BIX.02188",0.30803489723264,0.0486624812040823,FALSE +"transcriptomics","Pearson.est","MET inhibitor",-0.49285,-1.3,0.197,1427,0.497,"INC.280",0.705533773838407,0.303643611266668,FALSE +"transcriptomics","Pearson.est","microtubule inhibitor",-0.33844,-0.887,0.579,1335,0.819,"colchicine, estramustine.phosphate",0.237321436272564,0.0867160982395816,FALSE +"transcriptomics","Pearson.est","mTOR inhibitor",0.39799,1.01,0.426,507,0.668,"ku.0063794, voxtalisib, torin.1, AZD2014, MLN0128, NVP.BEZ235, WYE.354, XL388, LY303511, PF.04691502, GSK2126458, everolimus, AZD8055, SB.2343, WYE.125132",0.370590400897281,0.175223537524454,FALSE +"transcriptomics","Pearson.est","NFkB pathway inhibitor",-0.2821,-0.732,0.758,867,0.927,"BAY.11.7082, parthenolide, parthenolide...., BAY.11.7085, Ro.106.9920, tyloxapol, bindarit, IKK.2.inhibitor.V",0.120330794367946,0.0329202658555029,FALSE +"transcriptomics","Pearson.est","opioid receptor agonist",0.56438,1.43,0.136,123,0.762,"trimebutine, salvinorin.a",0.866461091629782,0.1180450286604,FALSE +"transcriptomics","Pearson.est","p38 MAPK inhibitor",-0.32354,-0.834,0.652,1191,0.876,"SB.239063, TAK.715, CMPD.1",0.18575240426808,0.0574958938319193,FALSE +"transcriptomics","Pearson.est","PARP inhibitor",0.49539,1.28,0.19,415,0.659,"olaparib, PJ.34, talazoparib, niraparib",0.721246399047171,0.18111458540599,FALSE +"transcriptomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.53283,1.37,0.147,199,0.766,"sorafenib, regorafenib, dovitinib, linifanib, masitinib, nintedanib, axitinib, crenolanib, pazopanib, CP.673451",0.832682665251824,0.115771230367396,FALSE +"transcriptomics","Pearson.est","phosphatase inhibitor",-0.51672,-1.34,0.175,1375,0.481,"mycophenolate.mofetil, BVT.948",0.756961951313706,0.317854923626168,FALSE +"transcriptomics","Pearson.est","phosphodiesterase inhibitor",-0.56107,-1.47,0.118,1297,0.434,"enoximone, zardaverine, cilostamide, GSK256066",0.928117992693875,0.362510270487489,FALSE +"transcriptomics","Pearson.est","PI3K inhibitor",0.29742,0.753,0.754,446,0.794,"GDC.0941, voxtalisib, NVP.BEZ235, ZSTK.474, LY303511, TG.100713, PI3K.IN.2, PF.04691502, alpelisib, CH5132799, GSK2126458, taselisib",0.122628654130226,0.100179497572904,FALSE +"transcriptomics","Pearson.est","PLK inhibitor",0.79215,2.06,0.00378,253,0.0743,"volasertib, NMS.1286937, GW.843682X, rigosertib, BI.2536, GSK461364",2.42250820016277,1.12901118623942,TRUE +"transcriptomics","Pearson.est","potassium channel blocker",0.34794,0.89,0.567,43,0.687,"ML133",0.246416941107093,0.16304326294045,FALSE +"transcriptomics","Pearson.est","PPAR receptor agonist",-0.51347,-1.34,0.165,1010,0.481,"S26948, clofibrate, oleoylethanolamide, GW.501516, pterostilbene",0.782516055786094,0.317854923626168,FALSE +"transcriptomics","Pearson.est","progesterone receptor agonist",0.40307,1.02,0.412,339,0.672,"nomegestrol.acetate, danazol, levonorgestrel, melengestrol.acetate, tanaproget",0.385102783966865,0.172630726946175,FALSE +"transcriptomics","Pearson.est","proteasome inhibitor",-0.63601,-1.64,0.0527,1283,0.244,"oprozomib, ONX.0914, ixazomib.citrate",1.27818938478745,0.612610173661271,FALSE +"transcriptomics","Pearson.est","protein synthesis inhibitor",0.25163,0.629,0.882,219,0.909,"anguidine, harringtonine, mercaptopurine",0.0545314148681803,0.0414361167780325,FALSE +"transcriptomics","Pearson.est","protein tyrosine kinase inhibitor",-0.26517,-0.685,0.851,1153,0.922,"CP.724714, rheochrysidin, NVP.TAE226",0.0700704399154121,0.0352690789463706,FALSE +"transcriptomics","Pearson.est","RAF inhibitor",0.36988,0.938,0.52,28,0.679,"sorafenib, regorafenib",0.283996656365201,0.168130225719498,FALSE +"transcriptomics","Pearson.est","RET tyrosine kinase inhibitor",0.68916,1.76,0.0232,28,0.546,"sorafenib, regorafenib",1.6345120151091,0.262807357295263,FALSE +"transcriptomics","Pearson.est","retinoid receptor agonist",0.35153,0.899,0.535,33,0.69,"bexarotene",0.271646217978772,0.161150909262745,FALSE +"transcriptomics","Pearson.est","ribonucleotide reductase inhibitor",0.47463,1.23,0.238,518,0.649,"cladribine, fludarabine.phosphate, cytarabine, triapine, pentostatin",0.623423042943488,0.187755303199631,FALSE +"transcriptomics","Pearson.est","serotonin receptor agonist",0.59318,1.51,0.0709,454,0.732,"zolmitriptan, NAN.190, SR.57227A, ipsapirone, aripiprazole",1.14935376481693,0.135488918941608,FALSE +"transcriptomics","Pearson.est","serotonin receptor antagonist",0.48277,1.22,0.247,77,0.636,"SB.216641, SB.200646, paliperidone",0.607303046740334,0.196542884351586,FALSE +"transcriptomics","Pearson.est","sodium channel blocker",-0.48589,-1.29,0.192,1358,0.47,"lappaconite, benzethonium, cibenzoline",0.71669877129645,0.327902142064283,FALSE +"transcriptomics","Pearson.est","src inhibitor",0.30204,0.772,0.723,86,0.799,"KX2.391, masitinib",0.140861702705469,0.0974532206860086,FALSE +"transcriptomics","Pearson.est","sterol demethylase inhibitor",0.46208,1.16,0.3,358,0.612,"lanoconazole, chlormidazole, sulconazole, ketoconazole, posaconazole",0.522878745280338,0.213248577854439,FALSE +"transcriptomics","Pearson.est","TGF beta receptor inhibitor",0.35971,0.921,0.536,142,0.672,"adaprev",0.27083521030723,0.172630726946175,FALSE +"transcriptomics","Pearson.est","thymidylate synthase inhibitor",0.46289,1.18,0.275,154,0.656,"trifluridine, carmofur",0.560667306169737,0.18309616062434,FALSE +"transcriptomics","Pearson.est","topoisomerase inhibitor",0.44261,1.13,0.315,221,0.593,"idarubicin, valrubicin, mitoxantrone, etoposide.phosphate, amonafide, TAS.103, amsacrine, topotecan, dexrazoxane",0.501689446210399,0.226945306635737,FALSE +"transcriptomics","Pearson.est","tubulin polymerization inhibitor",0.32697,0.831,0.655,569,0.742,"verubulin, KX2.391, docetaxel, mebendazole, vinblastine, taltobulin, flubendazole, BNC105, vindesine, oxibendazole, dolastatin.10, fosbretabulin, epothilone.b, CYT.997",0.183758700008217,0.129596094720973,FALSE +"transcriptomics","Pearson.est","tyrosine kinase inhibitor",0.40748,1.04,0.391,65,0.659,"sorafenib, regorafenib, hypericin, mubritinib",0.407823242604133,0.18111458540599,FALSE +"transcriptomics","Pearson.est","VEGFR inhibitor",0.44483,1.13,0.296,184,0.593,"sorafenib, tivozanib, regorafenib, dovitinib, ENMD.2076, linifanib, nintedanib, axitinib, foretinib, OSI.930, pazopanib",0.528708288941061,0.226945306635737,FALSE +"transcriptomics","Pearson.est","vitamin D receptor agonist",-0.65046,-1.66,0.0295,1262,0.264,"maxacalcitol, calcitriol, paricalcitol",1.53017798402184,0.578396073130169,FALSE +"proteomics","Pearson.est","EGFR inhibitor",-0.72318,-1.96,0.0125,1243,0.193,"AEE788, tucatinib, lapatinib, poziotinib, TAK.285, CP.724714, PD.153035, neratinib, XL.647, ARRY.334543, rociletinib, OSI.420, AZD8931, icotinib, BIBU.1361, BMS.690514, vandetanib, dacomitinib, PD.168393, erlotinib, gefitinib, afatinib, canertinib, osimertinib, WZ8040, pelitinib",1.90308998699194,0.714442690992226,TRUE +"proteomics","Pearson.est","Abl kinase inhibitor",-0.26364,-0.683,0.825,1241,1,"metatinib, bosutinib",0.0835460514500749,0,FALSE +"proteomics","Pearson.est","acetylcholine receptor agonist",0.61565,1.59,0.0524,281,0.636,"xanomeline, nicotine, pilocarpine",1.28066871301627,0.196542884351586,FALSE +"proteomics","Pearson.est","acetylcholine receptor antagonist",-0.34241,-0.911,0.517,1394,1,"dicycloverine",0.286509456906058,0,FALSE +"proteomics","Pearson.est","adenosine receptor antagonist",-0.64824,-1.69,0.0209,1379,0.468,"MRS.1220, CGS.15943",1.67985371388895,0.329754146925876,FALSE +"proteomics","Pearson.est","adrenergic receptor agonist",-0.25882,-0.684,0.827,1070,1,"isoetharine, A61603, oxymetazoline, methyldopa, isoxsuprine",0.0824944904474534,0,FALSE +"proteomics","Pearson.est","adrenergic receptor antagonist",0.24817,0.65,0.875,89,0.961,"dihydroergocristine, atipamezole, naftidrofuryl",0.0579919469776868,0.0172766123314547,FALSE +"proteomics","Pearson.est","AKT inhibitor",-0.40623,-1.03,0.384,904,0.785,"uprosertib, MK.2206, ONC201, GSK2110183, AZD5363, triciribine, CCT128930, palomid.529",0.415668775632469,0.105130343254747,FALSE +"proteomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.40527,-1.08,0.339,1084,0.767,"AZD3463, GW.788388, NVP.TAE684, AP26113, CEP.37440",0.469800301796918,0.115204636051019,FALSE +"proteomics","Pearson.est","androgen receptor antagonist",-0.22465,-0.592,0.934,807,0.925,"enzalutamide, nilutamide, bicalutamide, flutamide, cyproterone.acetate",0.0296531237699066,0.0338582672609674,FALSE +"proteomics","Pearson.est","antioxidant",0.39183,1.03,0.405,226,1,"trolox, mesna",0.392544976785331,0,FALSE +"proteomics","Pearson.est","AP inhibitor",-0.52133,-1.38,0.138,988,0.459,"LCL.161, GDC.0152, birinapant, tanshinone.i, embelin",0.860120913598763,0.338187314462739,FALSE +"proteomics","Pearson.est","ATPase inhibitor",0.75519,1.93,0.00192,172,0.15,"k.strophanthidin, oligomycin.a, digoxin, NMS.873, evodiamine, digitoxigenin, rabeprazole",2.71669877129645,0.823908740944319,TRUE +"proteomics","Pearson.est","Aurora kinase inhibitor",0.5415,1.4,0.112,203,0.94,"danusertib, ENMD.2076, barasertib, barasertib.HQPA, AMG900, PHA.680632, CCT137690, SNS.314, AT.9283, MK.5108",0.950781977329818,0.0268721464003014,FALSE +"proteomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.32274,0.822,0.669,341,0.968,"radezolid, josamycin",0.174573882232177,0.0141246426916063,FALSE +"proteomics","Pearson.est","bacterial DNA gyrase inhibitor",-0.25046,-0.649,0.883,1206,1,"trovafloxacin, sparfloxacin",0.0540392964224314,0,FALSE +"proteomics","Pearson.est","BCL inhibitor",0.19468,0.504,0.969,398,0.977,"TW.37, gossypol, venetoclax",0.0136762229492347,0.0101054362812269,FALSE +"proteomics","Pearson.est","Bcr.Abl kinase inhibitor",-0.33146,-0.849,0.628,1241,1,"metatinib, bosutinib",0.202040356262804,0,FALSE +"proteomics","Pearson.est","benzodiazepine receptor agonist",-0.28223,-0.753,0.741,405,1,"bentazepam, eprinomectin, ivermectin, piperazine, gamma.aminobutyric.acid, CL.218872, ZK.93423, lorazepam, nefiracetam, zaleplon, indiplon, temazepam, CGS.20625",0.130181792020672,0,FALSE +"proteomics","Pearson.est","bromodomain inhibitor",0.38558,1.01,0.446,892,0.99,"PFI.1, OTX015, I.BET151, JQ1...., bromosporine, I.BET.762",0.350665141287858,0.00436480540245009,FALSE +"proteomics","Pearson.est","calcium channel blocker",0.254,0.651,0.863,37,0.984,"carboxyamidotriazole",0.0639892042847904,0.00700490156865849,FALSE +"proteomics","Pearson.est","CC chemokine receptor antagonist",0.47512,1.28,0.175,219,0.782,"UNBS.5162, SB.225002, ZK811752",0.756961951313706,0.106793246940152,FALSE +"proteomics","Pearson.est","CDK inhibitor",-0.23141,-0.601,0.9,1038,0.942,"P276.00, dinaciclib, TG.02, BMS.387032, kenpaullone, alvocidib, arcyriaflavin.a, indirubin, CR8..R.",0.0457574905606751,0.0259490972071227,FALSE +"proteomics","Pearson.est","CHK inhibitor",-0.58219,-1.51,0.105,1005,0.482,"CHIR.124, AZD7762, LY2606368, SCH.900776, LY2603618",0.978810700930062,0.31695296176115,FALSE +"proteomics","Pearson.est","cyclooxygenase inhibitor",0.19906,0.519,0.971,128,0.993,"sulfasalazine, tepoxalin, phenazone",0.0127807700919951,0.00305075150461883,FALSE +"proteomics","Pearson.est","cytochrome P450 inhibitor",-0.23454,-0.617,0.906,1026,0.98,"itraconazole, clotrimazole, cobicistat",0.0428718023231869,0.00877392430750515,FALSE +"proteomics","Pearson.est","DNA alkylating agent",-0.27402,-0.731,0.785,1365,1,"ifosfamide, dacarbazine",0.105130343254747,0,FALSE +"proteomics","Pearson.est","DNA inhibitor",0.53842,1.39,0.121,306,0.729,"carboplatin, teroxirone, mechlorethamine, tirapazamine, sangivamycin, metronidazole, pibenzimol, chlorambucil, oxaliplatin, carmustine, valrubicin",0.91721462968355,0.137272471682025,FALSE +"proteomics","Pearson.est","DNA methyltransferase inhibitor",-0.57468,-1.47,0.0808,1290,0.493,"fdcyd, RG108, azacitidine",1.09258863922541,0.30715308072277,FALSE +"proteomics","Pearson.est","DNA polymerase inhibitor",-0.24801,-0.63,0.895,925,0.994,"famciclovir, adefovir.dipivoxil, menadione, cephalomannine, cidofovir",0.048176964684088,0.00261361560268669,FALSE +"proteomics","Pearson.est","DNA synthesis inhibitor",0.20875,0.538,0.969,40,1,"artesunate",0.0136762229492347,0,FALSE +"proteomics","Pearson.est","dopamine receptor antagonist",0.25594,0.651,0.883,218,0.984,"thioproperazine, UH.232...., domperidone",0.0540392964224314,0.00700490156865849,FALSE +"proteomics","Pearson.est","estrogen receptor agonist",0.35064,0.9,0.557,277,1,"estrone, erteberel, levonorgestrel, estradiol.cypionate",0.254144804826271,0,FALSE +"proteomics","Pearson.est","estrogen receptor antagonist",0.47827,1.22,0.234,513,0.798,"fulvestrant, tamoxifen, toremifene, danazol",0.630784142589857,0.0979971086492706,FALSE +"proteomics","Pearson.est","FGFR inhibitor",0.44698,1.15,0.292,317,0.913,"nintedanib, lenvatinib, dovitinib, regorafenib, AZD4547, erdafitinib",0.534617148551582,0.039529222465701,FALSE +"proteomics","Pearson.est","FLT3 inhibitor",0.27741,0.716,0.814,385,1,"tyrphostin.AG.1296, ENMD.2076, dovitinib, TG.101348, sorafenib, ponatinib",0.0893755951107988,0,FALSE +"proteomics","Pearson.est","glucocorticoid receptor agonist",0.40297,1.02,0.418,531,1,"beclomethasone.dipropionate, fluticasone.propionate, desonide, triamcinolone, dexamethasone.acetate, halcinonide, ciclesonide, hydrocortisone, clobetasol.propionate, fluocinolone.acetonide, prednisolone, rimexolone, methylprednisolone, halobetasol.propionate",0.378823718224965,0,FALSE +"proteomics","Pearson.est","glutamate receptor antagonist",-0.54008,-1.41,0.135,1123,0.449,"CPP, MTPG, diazooxonorleucine, SIB.1757, ACDPP, latrepirdine, LY456236",0.869666231504994,0.347753658996677,FALSE +"proteomics","Pearson.est","glycogen synthase kinase inhibitor",-0.59978,-1.56,0.0687,1180,0.541,"LY2090314, kenpaullone, AZD2858, indirubin, GSK.3.inhibitor.IX",1.16304326294045,0.266802734893431,FALSE +"proteomics","Pearson.est","growth factor receptor inhibitor",0.60653,1.53,0.0798,83,0.675,"PHA.848125, danusertib",1.09799710864927,0.170696227168975,FALSE +"proteomics","Pearson.est","HCV inhibitor",-0.56959,-1.46,0.131,1262,0.456,"PSI.7976, embelin, Ro.9187",0.882728704344236,0.341035157335565,FALSE +"proteomics","Pearson.est","HDAC inhibitor",-0.55487,-1.42,0.12,1125,0.477,"M.344, pyroxamide, vorinostat, givinostat, tacedinaline, mocetinostat, PCI.24781, entinostat, romidepsin, nexturastat.a, panobinostat, SB.939, JNJ.26481585",0.920818753952375,0.321481620959886,FALSE +"proteomics","Pearson.est","histamine receptor antagonist",-0.51244,-1.32,0.176,1016,0.481,"cimetidine, cyproheptadine, tiotidine, levocetirizine, zolantidine, ICI.162846, terfenadine, ebastine, tecastemizole, chloropyramine",0.75448733218585,0.317854923626168,FALSE +"proteomics","Pearson.est","HMGCR inhibitor",-0.45228,-1.19,0.25,1088,0.672,"mevastatin, simvastatin",0.602059991327962,0.172630726946175,FALSE +"proteomics","Pearson.est","HSP inhibitor",-0.52866,-1.35,0.172,1097,0.467,"NVP.AUY922, SNX.5422, XL888, tanespimycin, KW.2478, guanidine, VER.49009, alvespimycin",0.764471553092451,0.330683119433888,FALSE +"proteomics","Pearson.est","JAK inhibitor",-0.2933,-0.734,0.775,1373,1,"atiprimod, pacritinib, LY2784544",0.11069829749369,0,FALSE +"proteomics","Pearson.est","KIT inhibitor",0.32207,0.838,0.636,343,0.969,"masitinib, lenvatinib, pazopanib, regorafenib, OSI.930, sorafenib",0.196542884351586,0.0136762229492347,FALSE +"proteomics","Pearson.est","MDM inhibitor",0.53955,1.39,0.141,229,0.729,"idasanutlin, AMG.232, nutlin.3",0.85078088734462,0.137272471682025,FALSE +"proteomics","Pearson.est","MEK inhibitor",-0.30621,-0.804,0.697,1428,1,"BIX.02188, nobiletin",0.156767221901991,0,FALSE +"proteomics","Pearson.est","MET inhibitor",-0.27462,-0.714,0.8,396,1,"PHA.665752, PF.04217903, NVP.BVU972, LY2801653, INC.280, AMG458",0.0969100130080564,0,FALSE +"proteomics","Pearson.est","microtubule inhibitor",0.37806,0.97,0.475,348,1,"vinblastine, vinflunine, D.64131",0.323306390375133,0,FALSE +"proteomics","Pearson.est","mTOR inhibitor",0.36001,0.913,0.538,404,1,"AZD2014, MLN0128, voxtalisib, ku.0063794, WYE.125132, XL388, torin.1, PF.04691502, PP242, SB.2343, GSK2126458, NVP.BEZ235, GDC.0980",0.269217724333611,0,FALSE +"proteomics","Pearson.est","NFkB pathway inhibitor",0.29021,0.773,0.703,4,0.994,"EVP4593",0.153044674980176,0.00261361560268669,FALSE +"proteomics","Pearson.est","opioid receptor agonist",0.32692,0.864,0.607,338,1,"BW.180C, trimebutine, spiradoline",0.216811308924742,0,FALSE +"proteomics","Pearson.est","p38 MAPK inhibitor",-0.33949,-0.89,0.537,983,1,"CMPD.1, SB.239063, VX.702, TAK.715",0.270025714300444,0,FALSE +"proteomics","Pearson.est","PARP inhibitor",-0.22874,-0.608,0.935,984,0.962,"E7449, endo.IWR.1, PJ.34",0.0291883891274822,0.0168249279621871,FALSE +"proteomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.41356,1.08,0.352,195,0.977,"nintedanib, masitinib, linifanib, axitinib, lenvatinib, pazopanib, dovitinib, regorafenib",0.453457336521869,0.0101054362812269,FALSE +"proteomics","Pearson.est","phosphatase inhibitor",0.25763,0.659,0.848,182,1,"GSK2830371, bis.maltolato.oxovanadium.IV.",0.0716041477432862,0,FALSE +"proteomics","Pearson.est","phosphodiesterase inhibitor",-0.61329,-1.58,0.0552,1007,0.615,"papaverine, enoximone, cilostamide, avanafil, anagrelide, zardaverine, GSK256066, YM.976",1.2580609222708,0.211124884224583,FALSE +"proteomics","Pearson.est","PI3K inhibitor",0.36,0.94,0.507,419,1,"idelalisib, GDC.0941, voxtalisib, ZSTK.474, buparlisib, PF.04691502, SB.2343, GSK2126458, NVP.BEZ235, GDC.0980, PI3K.IN.2",0.294992040666664,0,FALSE +"proteomics","Pearson.est","PLK inhibitor",0.79112,2.02,0.00195,308,0.129,"volasertib, NMS.1286937, GW.843682X, HMN.214, rigosertib, GSK461364, BI.2536",2.70996538863748,0.889410289700751,TRUE +"proteomics","Pearson.est","potassium channel blocker",0.25659,0.661,0.877,1078,1,"ML133, ibutilide, mepivacaine, meglitinide, oleoylethanolamide, dofetilide",0.0570004066339595,0,FALSE +"proteomics","Pearson.est","PPAR receptor agonist",0.30023,0.771,0.715,184,0.967,"clofibrate, fenofibrate",0.145693958198919,0.0145735259169983,FALSE +"proteomics","Pearson.est","progesterone receptor agonist",0.50904,1.31,0.177,216,0.777,"tanaproget, nomegestrol.acetate, levonorgestrel",0.752026733638193,0.109578981199086,FALSE +"proteomics","Pearson.est","proteasome inhibitor",-0.65054,-1.7,0.0343,1131,0.661,"ixazomib, ONX.0914, carfilzomib, bortezomib, ixazomib.citrate",1.46470587995723,0.17979854051436,FALSE +"proteomics","Pearson.est","protein synthesis inhibitor",0.47636,1.23,0.229,276,0.838,"harringtonine, anguidine, cycloheximide, clofoctol, mercaptopurine, bruceantin, clindamycin.phosphate, chloramphenicol.palmitate",0.640164517660112,0.0767559813697235,FALSE +"proteomics","Pearson.est","protein tyrosine kinase inhibitor",0.32762,0.861,0.611,6,0.99,"mubritinib",0.213958789757446,0.00436480540245009,FALSE +"proteomics","Pearson.est","RAF inhibitor",-0.40671,-1.04,0.391,1276,0.807,"CEP.32496, vemurafenib, dabrafenib",0.407823242604133,0.0931264652779296,FALSE +"proteomics","Pearson.est","RET tyrosine kinase inhibitor",-0.42082,-1.1,0.32,1259,0.816,"apatinib, vandetanib",0.494850021680094,0.0883098412461389,FALSE +"proteomics","Pearson.est","retinoid receptor agonist",0.34224,0.891,0.54,307,1,"adapalene, fenretinide, LE.135, bexarotene",0.267606240177031,0,FALSE +"proteomics","Pearson.est","ribonucleotide reductase inhibitor",0.21365,0.544,0.962,464,1,"hydroxyurea, pentostatin, triapine, fludarabine.phosphate, LY2334737",0.0168249279621871,0,FALSE +"proteomics","Pearson.est","serotonin receptor agonist",0.34747,0.9,0.566,314,1,"zolmitriptan, NAN.190",0.247183568811729,0,FALSE +"proteomics","Pearson.est","serotonin receptor antagonist",0.31056,0.808,0.659,147,0.962,"SB.200646, pirenperone",0.18111458540599,0.0168249279621871,FALSE +"proteomics","Pearson.est","sodium channel blocker",-0.4194,-1.08,0.329,1341,0.767,"lappaconite, triamterene, mexiletine",0.482804102050026,0.115204636051019,FALSE +"proteomics","Pearson.est","src inhibitor",-0.31014,-0.804,0.692,1189,1,"PP.2, bosutinib, saracatinib",0.159893905543242,0,FALSE +"proteomics","Pearson.est","sterol demethylase inhibitor",0.64713,1.63,0.0449,159,0.691,"chlormidazole, sulconazole, posaconazole",1.34775365899668,0.160521952625802,FALSE +"proteomics","Pearson.est","TGF beta receptor inhibitor",-0.58093,-1.52,0.0869,1183,0.539,"SB.431542, D.4476, repsox, LY2109761",1.06098022355133,0.268411234813261,FALSE +"proteomics","Pearson.est","thymidylate synthase inhibitor",0.33058,0.854,0.625,34,0.97,"ftorafur",0.204119982655925,0.0132282657337552,FALSE +"proteomics","Pearson.est","topoisomerase inhibitor",0.42309,1.09,0.32,306,1,"mitoxantrone, idarubicin, etoposide.phosphate, epirubicin, dexrazoxane, doxorubicin, TAS.103, amsacrine, topotecan, voreloxin, valrubicin",0.494850021680094,0,FALSE +"proteomics","Pearson.est","tubulin polymerization inhibitor",0.5097,1.32,0.158,555,0.835,"verubulin, BNC105, vinblastine, fenbendazole, vindesine, KX2.391, mebendazole, taltobulin, oxibendazole, paclitaxel, docetaxel, ABT.751, epothilone.b, indibulin, nocodazole, dolastatin.10, CYT.997, albendazole, fosbretabulin",0.801342913045577,0.0783135245163979,FALSE +"proteomics","Pearson.est","tyrosine kinase inhibitor",-0.27733,-0.717,0.787,1249,1,"AV.412, apatinib, CP.724714, rheochrysidin, vandetanib",0.104025267640935,0,FALSE +"proteomics","Pearson.est","VEGFR inhibitor",0.25686,0.659,0.866,195,1,"nintedanib, SAR131675, linifanib, ENMD.2076, axitinib, lenvatinib, pazopanib, dovitinib, regorafenib",0.0624821079826534,0,FALSE +"proteomics","Pearson.est","vitamin D receptor agonist",-0.25293,-0.653,0.859,917,1,"ercalcitriol, tacalcitol, paricalcitol, maxacalcitol, calcitriol",0.0660068361687577,0,FALSE +"metabolomics","Pearson.est","EGFR inhibitor",-0.31798,-0.841,0.637,1024,0.798,"FERb.033, BMS.599626, BIBU.1361, BMS.690514, salvianolic.acid.B, tucatinib, canertinib, PD.168393, neratinib, pelitinib, TAK.285, vandetanib, afatinib, OSI.420, AEE788, brigatinib, osimertinib, PD.153035",0.19586056766465,0.0979971086492706,FALSE +"metabolomics","Pearson.est","Abl kinase inhibitor",-0.63565,-1.66,0.0583,1039,0.258,"flumatinib, bosutinib, imatinib, GZD824, bafetinib, nilotinib, metatinib, dasatinib, ponatinib",1.23433144524099,0.58838029403677,FALSE +"metabolomics","Pearson.est","acetylcholine receptor agonist",0.42151,1.1,0.344,240,0.657,"pilocarpine, oxiracetam, nefiracetam",0.46344155742847,0.182434630440219,FALSE +"metabolomics","Pearson.est","acetylcholine receptor antagonist",0.22648,0.586,0.944,466,0.978,"diphemanil, methscopolamine, iododexetimide",0.025028005701931,0.00966114521239857,FALSE +"metabolomics","Pearson.est","adenosine receptor antagonist",0.37014,0.943,0.522,275,0.638,"SCH.58261, sulmazole",0.282329496997738,0.195179321278838,FALSE +"metabolomics","Pearson.est","adrenergic receptor agonist",-0.36429,-0.971,0.455,1141,0.646,"isoetharine, metaraminol, clenbuterol, A61603, epinephrine, terbutaline",0.341988603342888,0.189767482004916,FALSE +"metabolomics","Pearson.est","adrenergic receptor antagonist",0.368,0.959,0.496,248,0.656,"atenolol......, prazosin, propranolol, oxprenolol, naftidrofuryl",0.304518323509803,0.18309616062434,FALSE +"metabolomics","Pearson.est","AKT inhibitor",0.21193,0.542,0.961,539,0.983,"AT7867, ONC201, GDC.0068, CCT128930, uprosertib",0.0172766123314547,0.00744648216786438,FALSE +"metabolomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.53809,-1.41,0.135,1247,0.365,"GW.788388, brigatinib, CEP.37440, AP26113",0.869666231504994,0.437707135543525,FALSE +"metabolomics","Pearson.est","androgen receptor antagonist",0.65925,1.72,0.0255,378,0.209,"bicalutamide, nilutamide, RU.58841, enzalutamide",1.59345981956604,0.679853713888946,TRUE +"metabolomics","Pearson.est","antioxidant",0.28363,0.73,0.776,1039,0.845,"trolox, mesna, benfotiamine, chlorogenic.acid, taurine, rutin",0.110138278741812,0.0731432910503077,FALSE +"metabolomics","Pearson.est","AP inhibitor",-0.32039,-0.836,0.642,462,0.784,"birinapant, tanshinone.i, GDC.0152, idronoxil, embelin, LCL.161",0.192464971931147,0.105683937315562,FALSE +"metabolomics","Pearson.est","ATPase inhibitor",0.42817,1.07,0.368,354,0.651,"rabeprazole, oligomycin.a, evodiamine, digitoxigenin, digitoxin, k.strophanthidin",0.434152181326482,0.186419011431808,FALSE +"metabolomics","Pearson.est","Aurora kinase inhibitor",0.44069,1.13,0.291,395,0.711,"CCT129202, PHA.680632, barasertib, danusertib, AMG900, GSK1070916, AT.9283, barasertib.HQPA, SNS.314, CCT137690",0.536107011014093,0.148130399270234,FALSE +"metabolomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.40441,-1.07,0.367,1301,0.549,"dirithromycin, tedizolid",0.435333935747911,0.260427655549908,FALSE +"metabolomics","Pearson.est","bacterial DNA gyrase inhibitor",0.33267,0.843,0.604,109,0.729,"norfloxacin, finafloxacin",0.218963061378868,0.137272471682025,FALSE +"metabolomics","Pearson.est","BCL inhibitor",-0.41158,-1.07,0.373,1187,0.549,"gossypol, HA14.1, navitoclax, oridonin",0.428291168191312,0.260427655549908,FALSE +"metabolomics","Pearson.est","Bcr.Abl kinase inhibitor",-0.68734,-1.78,0.0186,1039,0.235,"flumatinib, bosutinib, imatinib, GZD824, bafetinib, nilotinib, metatinib, dasatinib, ponatinib",1.73048705578208,0.628932137728264,TRUE +"metabolomics","Pearson.est","benzodiazepine receptor agonist",0.40418,1.03,0.422,37,0.613,"eprinomectin, bentazepam",0.374687549038326,0.212539525481585,FALSE +"metabolomics","Pearson.est","bromodomain inhibitor",-0.47947,-1.24,0.23,1045,0.51,"bromosporine, PFI.1, OTX015",0.638272163982407,0.292429823902064,FALSE +"metabolomics","Pearson.est","calcium channel blocker",-0.25875,-0.669,0.852,1197,0.939,"penfluridol, tetrandrine, SKF.96365",0.0695604052332999,0.0273344077338891,FALSE +"metabolomics","Pearson.est","CC chemokine receptor antagonist",-0.36725,-0.968,0.483,1113,0.631,"RS.504393, UNBS.5162, navarixin",0.316052869248488,0.199970640755866,FALSE +"metabolomics","Pearson.est","CDK inhibitor",-0.40931,-1.06,0.344,996,0.545,"arcyriaflavin.a, NU6027, kenpaullone, JNJ.7706621, palbociclib, aminopurvalanol.a, AT.7519, ribociclib, P276.00, abemaciclib",0.46344155742847,0.263603497723358,FALSE +"metabolomics","Pearson.est","CHK inhibitor",-0.72589,-1.89,0.0146,1225,0.431,"LY2603618, AZD7762, LY2606368, SCH.900776",1.83564714421556,0.365522729839268,FALSE +"metabolomics","Pearson.est","cyclooxygenase inhibitor",-0.22301,-0.583,0.94,1233,0.978,"tryptanthrin, acetylsalicylsalicylic.acid, suxibuzone, FR.122047, indoprofen",0.0268721464003014,0.00966114521239857,FALSE +"metabolomics","Pearson.est","cytochrome P450 inhibitor",-0.45847,-1.18,0.273,1356,0.506,"itraconazole",0.563837352959244,0.295849483160201,FALSE +"metabolomics","Pearson.est","DNA alkylating agent",-0.46038,-1.17,0.29,1423,0.499,"cisplatin, ifosfamide, estramustine",0.537602002101044,0.30189945437661,FALSE +"metabolomics","Pearson.est","DNA inhibitor",0.4887,1.25,0.224,335,0.599,"carboplatin, mechlorethamine, bendamustine, tirapazamine, teroxirone, oxaliplatin, metronidazole",0.649751981665837,0.222573177610689,FALSE +"metabolomics","Pearson.est","DNA methyltransferase inhibitor",-0.58817,-1.51,0.0788,1041,0.409,"SGI.1027, RG108, fdcyd, decitabine, azacitidine",1.10347378251044,0.388276691992658,FALSE +"metabolomics","Pearson.est","DNA polymerase inhibitor",0.4081,1.07,0.362,176,0.651,"famciclovir, cephalomannine, foscarnet",0.441291429466834,0.186419011431808,FALSE +"metabolomics","Pearson.est","DNA synthesis inhibitor",-0.31726,-0.814,0.67,1268,0.797,"capecitabine, enocitabine, cisplatin",0.173925197299174,0.0985416786038876,FALSE +"metabolomics","Pearson.est","dopamine receptor antagonist",0.5606,1.46,0.0984,208,0.506,"thioproperazine, clebopride, lurasidone, raclopride, remoxipride, isofloxythepin",1.00700490156866,0.295849483160201,FALSE +"metabolomics","Pearson.est","estrogen receptor agonist",0.44832,1.17,0.272,213,0.67,"estrone, ethinyl.estradiol, erteberel, levonorgestrel",0.565431095965801,0.173925197299174,FALSE +"metabolomics","Pearson.est","estrogen receptor antagonist",0.404,1.04,0.373,242,0.648,"raloxifene, clomifene",0.428291168191312,0.188424994129407,FALSE +"metabolomics","Pearson.est","FGFR inhibitor",-0.41963,-1.11,0.34,1082,0.529,"MK.2461, nintedanib, erdafitinib, lucitanib",0.468521082957745,0.276544327964814,FALSE +"metabolomics","Pearson.est","FLT3 inhibitor",-0.28822,-0.739,0.785,1321,0.891,"midostaurin, ponatinib, gilteritinib",0.105130343254747,0.0501222959631252,FALSE +"metabolomics","Pearson.est","glucocorticoid receptor agonist",0.69184,1.79,0.00735,314,0.166,"hydrocortisone, prednisolone, desonide, methylprednisolone, fluticasone.propionate, ciclesonide, halcinonide, triamcinolone.acetonide, dexamethasone.acetate, rimexolone, fluocinolone.acetonide, prednisolone.acetate, triamcinolone, betamethasone, flumethasone.pivalate, difluprednate, piretanide",2.13371266091581,0.779891911959945,TRUE +"metabolomics","Pearson.est","glutamate receptor antagonist",0.36763,0.939,0.525,151,0.624,"tiletamine, latrepirdine, MTPG",0.279840696594043,0.204815410317576,FALSE +"metabolomics","Pearson.est","glycogen synthase kinase inhibitor",-0.36358,-0.945,0.486,1003,0.649,"AZD2858, kenpaullone, LY2090314, tideglusib, GSK.3.inhibitor.IX",0.313363730737707,0.187755303199631,FALSE +"metabolomics","Pearson.est","growth factor receptor inhibitor",0.4,1.03,0.417,377,0.613,"danusertib, GW.441756, PHA.848125, GSK1904529A",0.379863945026242,0.212539525481585,FALSE +"metabolomics","Pearson.est","HCV inhibitor",0.65894,1.7,0.0229,31,0.198,"PSI.7976, narlaprevir",1.64016451766011,0.703334809738469,TRUE +"metabolomics","Pearson.est","HDAC inhibitor",-0.57246,-1.45,0.111,1099,0.392,"nexturastat.a, AR.42, PCI.24781, mocetinostat, belinostat, M.344, entinostat, SB.939, dacinostat, resminostat, givinostat, panobinostat, R306465, RG2833, JNJ.26481585",0.954677021213343,0.406713932979543,FALSE +"metabolomics","Pearson.est","histamine receptor antagonist",0.4019,1.05,0.367,407,0.659,"ranitidine, famotidine, terfenadine, epinastine, zolantidine, nizatidine, ICI.162846, tecastemizole",0.435333935747911,0.18111458540599,FALSE +"metabolomics","Pearson.est","HMGCR inhibitor",0.45254,1.18,0.27,10,0.692,"fluvastatin",0.568636235841013,0.159893905543242,FALSE +"metabolomics","Pearson.est","HSP inhibitor",-0.18606,-0.475,0.986,267,0.986,"NMS.E973, tanespimycin, PU.H71, XL888, SNX.2112, alvespimycin, guanidine, KW.2478, ganetespib, VER.49009, NVP.AUY922, BIIB021, SNX.5422",0.0061230850587888,0.0061230850587888,FALSE +"metabolomics","Pearson.est","JAK inhibitor",0.43162,1.12,0.326,294,0.654,"TG.101348, WHI.P154, CEP.33779, AZD1480, filgotinib, AT.9283",0.486782399932061,0.184422251675733,FALSE +"metabolomics","Pearson.est","KIT inhibitor",-0.60624,-1.54,0.0784,1066,0.4,"imatinib, vatalanib, sorafenib, sunitinib, telatinib, dasatinib, midostaurin, pazopanib, motesanib, KI.8751",1.10568393731556,0.397940008672038,FALSE +"metabolomics","Pearson.est","MDM inhibitor",0.8318,2.13,0.00188,145,0.0299,"idasanutlin, CGM097, AMG.232, nutlin.3, RITA",2.72584215073632,1.52432881167557,TRUE +"metabolomics","Pearson.est","MEK inhibitor",-0.56535,-1.49,0.0833,1131,0.361,"AS.703026, arctigenin, PD.184352, AZD8330, selumetinib, TAK.733, nobiletin, trametinib, BIX.02188, cobimetinib",1.07935499859321,0.442492798094342,FALSE +"metabolomics","Pearson.est","MET inhibitor",-0.69421,-1.82,0.0179,1143,0.243,"PHA.665752, PF.04217903, LY2801653, INC.280, NVP.BVU972",1.74714696902011,0.614393726401688,TRUE +"metabolomics","Pearson.est","microtubule inhibitor",0.3641,0.952,0.495,336,0.645,"vinblastine, cabazitaxel, colchicine, triclabendazole",0.305394801066431,0.190440285364732,FALSE +"metabolomics","Pearson.est","mTOR inhibitor",0.2953,0.763,0.758,300,0.823,"torin.1, AZD8055, SB.2343, ku.0063794, WYE.125132, PP242, voxtalisib, PF.04691502, OSI.027",0.120330794367946,0.0846001647877302,FALSE +"metabolomics","Pearson.est","NFkB pathway inhibitor",0.38396,0.985,0.452,105,0.66,"parthenolide...., EVP4593, tyloxapol",0.344861565188618,0.180456064458131,FALSE +"metabolomics","Pearson.est","opioid receptor agonist",0.34303,0.87,0.619,363,0.708,"salvinorin.a, spiradoline, ADL5859",0.208309350979882,0.149966742310231,FALSE +"metabolomics","Pearson.est","p38 MAPK inhibitor",0.56967,1.45,0.129,245,0.467,"talmapimod, SB.242235, skepinone.l",0.889410289700751,0.330683119433888,FALSE +"metabolomics","Pearson.est","PARP inhibitor",0.57127,1.44,0.099,267,0.399,"AG.14361, niraparib, olaparib",1.00436480540245,0.399027104313252,FALSE +"metabolomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.51612,-1.34,0.144,1066,0.412,"imatinib, vatalanib, nintedanib, sorafenib, CP.673451, sunitinib, telatinib, dasatinib, pazopanib, SU014813, ponatinib, motesanib, KI.8751",0.84163750790475,0.385102783966865,FALSE +"metabolomics","Pearson.est","phosphatase inhibitor",-0.25312,-0.648,0.855,1287,0.94,"BVT.948, AS.1949490",0.0680338852718274,0.0268721464003014,FALSE +"metabolomics","Pearson.est","phosphodiesterase inhibitor",-0.47393,-1.22,0.235,1174,0.491,"GSK256066, zardaverine, trequinsin, YM.976",0.628932137728264,0.308918507877032,FALSE +"metabolomics","Pearson.est","PI3K inhibitor",0.18031,0.469,0.985,321,0.987,"AZD6482, SB.2343, voxtalisib, PF.04691502, YM.201636, idelalisib",0.00656376950238827,0.00568284733036327,FALSE +"metabolomics","Pearson.est","PLK inhibitor",0.51495,1.33,0.157,204,0.537,"NMS.1286937, HMN.214",0.804100347590766,0.270025714300444,FALSE +"metabolomics","Pearson.est","potassium channel blocker",-0.4473,-1.15,0.283,1238,0.51,"mepivacaine, dofetilide",0.54821356447571,0.292429823902064,FALSE +"metabolomics","Pearson.est","PPAR receptor agonist",0.69707,1.85,0.0139,409,0.137,"clofibrate, fenofibrate, pterostilbene, S26948",1.8569851997459,0.863279432843593,TRUE +"metabolomics","Pearson.est","progesterone receptor agonist",0.49075,1.25,0.223,384,0.599,"norethindrone, levonorgestrel, norgestrel, tanaproget",0.651695136951839,0.222573177610689,FALSE +"metabolomics","Pearson.est","proteasome inhibitor",-0.67717,-1.71,0.026,1313,0.232,"bortezomib, ixazomib.citrate, carfilzomib",1.58502665202918,0.6345120151091,TRUE +"metabolomics","Pearson.est","protein synthesis inhibitor",0.43741,1.12,0.312,305,0.654,"mercaptopurine, bruceantin, anguidine, chloramphenicol.palmitate, clofoctol, cycloheximide, harringtonine, tedizolid.phosphate",0.505845405981557,0.184422251675733,FALSE +"metabolomics","Pearson.est","protein tyrosine kinase inhibitor",-0.39131,-1.03,0.387,1048,0.57,"BMS.599626, NVP.TAE226, AV.412, tyrphostin.A9, rheochrysidin",0.412289034981089,0.244125144327509,FALSE +"metabolomics","Pearson.est","RAF inhibitor",-0.72224,-1.85,0.0142,1106,0.286,"CEP.32496, SB.590885, sorafenib, GDC.0879, LGX818, RAF265, AZ.628, TAK.632, dabrafenib, vemurafenib",1.84771165561694,0.543633966870957,FALSE +"metabolomics","Pearson.est","RET tyrosine kinase inhibitor",-0.66466,-1.71,0.0394,1010,0.232,"apatinib, sorafenib, sunitinib, vandetanib",1.40450377817443,0.6345120151091,TRUE +"metabolomics","Pearson.est","retinoid receptor agonist",-0.42578,-1.12,0.305,1142,0.535,"fenretinide, LE.135, CD.437, tamibarotene, adarotene",0.515700160653214,0.271646217978772,FALSE +"metabolomics","Pearson.est","ribonucleotide reductase inhibitor",-0.46168,-1.22,0.219,1084,0.491,"cladribine, LY2334737, fludarabine, triapine, hydroxyurea, clofarabine",0.659555885159882,0.308918507877032,FALSE +"metabolomics","Pearson.est","serotonin receptor agonist",0.62103,1.59,0.0396,3,0.322,"aripiprazole",1.40230481407449,0.492144128304169,FALSE +"metabolomics","Pearson.est","serotonin receptor antagonist",0.3806,0.976,0.467,141,0.651,"aripiprazole, lurasidone, pirenperone",0.330683119433888,0.186419011431808,FALSE +"metabolomics","Pearson.est","sodium channel blocker",-0.19096,-0.498,0.991,949,1,"triamterene, quinidine, oxcarbazepine, lappaconite, benzethonium, mexiletine, mepivacaine",0.00392634551472468,0,FALSE +"metabolomics","Pearson.est","src inhibitor",-0.56198,-1.49,0.097,1245,0.361,"PP.1, dasatinib, saracatinib, TG.100572",1.01322826573376,0.442492798094342,FALSE +"metabolomics","Pearson.est","sterol demethylase inhibitor",0.7524,1.92,0,259,0.116,"terconazole, posaconazole, ketoconazole, chlormidazole",Inf,0.935542010773082,TRUE +"metabolomics","Pearson.est","TGF beta receptor inhibitor",-0.27115,-0.713,0.791,391,0.907,"adaprev, SB.525334, SB.431542, D.4476, LY2109761, repsox",0.101823516502323,0.0423927129399047,FALSE +"metabolomics","Pearson.est","thymidylate synthase inhibitor",-0.48402,-1.26,0.214,1031,0.506,"raltitrexed, trifluridine, doxifluridine, capecitabine",0.669586226650809,0.295849483160201,FALSE +"metabolomics","Pearson.est","topoisomerase inhibitor",-0.5355,-1.42,0.102,1070,0.378,"licochalcone.a, SN.38, beta.lapachone, genz.644282, doxorubicin, teniposide, exatecan.mesylate, fleroxacin, rubitecan, daunorubicin, camptothecin, etoposide, irinotecan",0.991399828238082,0.422508200162775,FALSE +"metabolomics","Pearson.est","tubulin polymerization inhibitor",0.57189,1.44,0.106,483,0.399,"BNC105, epothilone.b, vinorelbine, flubendazole, vinblastine, dolastatin.10, mebendazole, taltobulin, nocodazole, indibulin, KX2.391, oxibendazole, fosbretabulin, verubulin, CYT.997, epothilone.d, ABT.751, vincristine",0.97469413473523,0.399027104313252,FALSE +"metabolomics","Pearson.est","tyrosine kinase inhibitor",-0.45948,-1.2,0.247,1126,0.496,"sorafenib, NVP.TAE226, AV.412, aminopurvalanol.a, tyrphostin.A9, sunitinib, bafetinib, rheochrysidin, vandetanib, tivantinib, dasatinib, hypericin",0.607303046740334,0.304518323509803,FALSE +"metabolomics","Pearson.est","VEGFR inhibitor",-0.53789,-1.42,0.11,1081,0.378,"BMS.690514, MK.2461, vatalanib, MGCD.265, nintedanib, sorafenib, sunitinib, vandetanib, RAF265, 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+"KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.653,1.59381868479448,0.0988641838634014,"transcriptomics, proteomics",2,1,"transcriptomics",0.509186963684416 +"KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.6775,2.04000306372319,0.0270572557103867,"transcriptomics, proteomics",2,0,"",0.374638925220738 +"KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.679,NA,NA,"transcriptomics",1,0,"",NA +"KEGG_PYRIMIDINE_METABOLISM",-0.7645,0.23546655813512,0.860202570783159,"transcriptomics, proteomics",2,0,"",0.973783396193417 +"KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.806,0.401636651713959,0.627885566032803,"transcriptomics, proteomics",2,0,"",0.891752231843372 +"KEGG_ALLOGRAFT_REJECTION",-0.807,NA,NA,"transcriptomics",1,0,"",NA +"KEGG_HUNTINGTONS_DISEASE",-0.814,0.291327993848858,0.739114047366216,"transcriptomics, proteomics",2,0,"",0.941609966303691 +"KEGG_BETA_ALANINE_METABOLISM",-0.835,0.00424264068711929,0.783011460771304,"transcriptomics, proteomics",2,0,"",0.958789543801597 +"KEGG_GAP_JUNCTION",-0.866,0.373352380466497,0.598593325122088,"transcriptomics, proteomics",2,0,"",0.876656581794286 +"KEGG_PURINE_METABOLISM",-0.884,0.17819090885901,0.599048664226095,"transcriptomics, proteomics",2,0,"",0.876656581794286 +"KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.9615,0.252437120883597,0.515300364096958,"transcriptomics, proteomics",2,0,"",0.82816129944154 +"KEGG_REGULATION_OF_AUTOPHAGY",-0.988,0.398808224589213,0.47673446521645,"transcriptomics, proteomics",2,0,"",0.8172590832282 +"KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.989,0.340825468531916,0.492504604487226,"transcriptomics, proteomics",2,0,"",0.827793835551903 +"KEGG_PARKINSONS_DISEASE",-1.007,0.527501658765164,0.344234056941909,"transcriptomics, proteomics",2,0,"",0.719540934814592 +"KEGG_PROTEIN_EXPORT",-1.06,0.0424264068711929,0.390838753342179,"transcriptomics, proteomics",2,0,"",0.732822662516586 +"KEGG_DNA_REPLICATION",-1.075,0.657609306503489,0.127061226224373,"transcriptomics, proteomics",2,0,"",0.55886923320755 +"KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-1.0935,0.461740728114815,0.273580409275154,"transcriptomics, proteomics",2,0,"",0.679941153934616 +"KEGG_MELANOMA",-1.107,0.230516810666815,0.314238519866347,"transcriptomics, proteomics",2,0,"",0.698307821925215 +"KEGG_SPLICEOSOME",-1.1435,0.23546655813512,0.25472078183329,"transcriptomics, proteomics",2,0,"",0.654996296142745 +"KEGG_ASTHMA",-1.2,NA,NA,"transcriptomics",1,0,"",NA +"KEGG_RNA_POLYMERASE",-1.215,0.00707106781186548,0.179784464973633,"transcriptomics, proteomics",2,0,"",0.580027921612858 +"KEGG_BASAL_TRANSCRIPTION_FACTORS",-1.225,0.0494974746830584,0.159226874568896,"transcriptomics, proteomics",2,0,"",0.559561738554814 +"KEGG_RNA_DEGRADATION",-1.335,0.106066017177982,0.0678705513843905,"transcriptomics, proteomics",2,0,"",0.488563619880045 +"acyl carnitines",-1.38,NA,NA,"metabolomics",1,0,"",NA +"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-1.4235,0.645588491223318,0.0515831087853856,"transcriptomics, proteomics",2,1,"transcriptomics",0.488563619880045 +"KEGG_RIBOSOME",-1.425,0.190918830920368,0.0802871241396461,"transcriptomics, proteomics",2,0,"",0.488563619880045 +"alpha amino acids",-1.44,NA,NA,"metabolomics",1,0,"",NA +"KEGG_AUTOIMMUNE_THYROID_DISEASE",-1.46,NA,NA,"transcriptomics",1,0,"",NA +"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-1.55,0.551543289325507,0.0158758045857219,"transcriptomics, proteomics",2,1,"transcriptomics",0.285764482542995 +"KEGG_ONE_CARBON_POOL_BY_FOLATE",-1.565,0.00707106781186548,0.0240143366970624,"transcriptomics, proteomics",2,0,"",0.360215050455935 +"KEGG_LIMONENE_AND_PINENE_DEGRADATION",-1.68,0.282842712474619,0.00983411446231775,"transcriptomics, proteomics",2,0,"",0.221267575402149 +"KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-1.795,0.0353553390593274,0.00190190546248448,"transcriptomics, proteomics",2,1,"transcriptomics",0.0855857458118017 +"KEGG_NON_HOMOLOGOUS_END_JOINING",-2.015,0.106066017177982,NA,"transcriptomics, proteomics",2,2,"transcriptomics, proteomics",NA diff --git a/Examples/Fig5/GSEA/GSEA_results.csv b/Examples/Fig5/GSEA/GSEA_results.csv new file mode 100644 index 0000000..c324572 --- /dev/null +++ b/Examples/Fig5/GSEA/GSEA_results.csv @@ -0,0 +1,370 @@ +"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"transcriptomics","Log2FC","KEGG_ABC_TRANSPORTERS",0.23561,0.678,0.94,7191,1,"ABCA12, ABCB8, ABCB9, ABCA13, ABCD1, ABCC3, ABCA1, ABCA2, ABCB11, ABCC10, ABCD4, ABCA4, ABCC5, ABCA5, TAP2, ABCC11, ABCG1, ABCB6, ABCG2",0.0268721464003014,0,FALSE +"transcriptomics","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.36169,1.04,0.374,5916,0.766,"PIK3R2, IKBKB, MAPK3, RPS6KB2, PML, RARA, PIK3CA, JUP, STAT5B, STAT3, BRAF, RELA, TCF7L1, RUNX1, BAD, PIM1, PIK3R3, CCNA1, STAT5A, MAPK1, PIK3R5, PIK3CB, CEBPA",0.42712839779952,0.115771230367396,FALSE +"transcriptomics","Log2FC","KEGG_ADHERENS_JUNCTION",0.36058,1.03,0.394,3562,0.786,"NECTIN1, CTNND1, CDH1, ERBB2, BAIAP2, NECTIN4, PTPN1, RAC2, MAPK3, INSR, PTPN6, SNAI2, MET, IGF1R, EP300, EGFR, PTPRF, TCF7L1, PTPRB, SRC",0.404503778174426,0.104577453960592,FALSE +"transcriptomics","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.27558,0.798,0.819,5975,1,"TRADD, RXRA, CPT1B, PPARA, IKBKB, ACSL1, RXRB, CPT1C, ADIPOR1, IRS2, STAT3, PRKAA1, RELA, ACSL3, PRKAG2, PRKAB2, ACSL5, ACSL6, SLC2A1, MAPK10, IRS1, NFKBIA",0.0867160982395816,0,FALSE +"transcriptomics","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.44972,1.32,0.102,3496,0.756,"GLUL, AGXT, GLS2, ASL, ABAT, ASS1, GPT, NIT2, IL4I1",0.991399828238082,0.121478204498793,FALSE +"transcriptomics","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.37286,1.08,0.322,5894,0.74,"PIK3R2, SCNN1A, MAPK3, INSR, PIK3CA, SFN, SCNN1G, IRS2, NEDD4L, PIK3R3, SCNN1B, HSD11B2, MAPK1, PIK3R5, IRS1, PIK3CB",0.492144128304169,0.130768280269024,FALSE +"transcriptomics","Log2FC","KEGG_ALLOGRAFT_REJECTION",-0.23407,-0.807,0.727,16990,1,"PRF1, IL5",0.138465589140962,0,FALSE +"transcriptomics","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.40981,1.18,0.214,3971,0.738,"PLA2G12A, PLA2G6, PLA2G4B, PLA2G10, PLA2G4E, ACOX1, PLA2G2C",0.669586226650809,0.131943638176958,FALSE +"transcriptomics","Log2FC","KEGG_ALZHEIMERS_DISEASE",0.24418,0.704,0.903,6624,0.99,"NDUFV1, CAPN1, CACNA1D, GRIN1, ATP2A3, CALML3, COX5B, LRP1, ATP5F1E, NDUFB7, MAPK3, CDK5, FADD, NDUFS8, EIF2AK3, NDUFA3, NDUFV2, COX6C, UQCR10, GRIN2A, APH1A, COX6B2, GRIN2D, CHP1, PPP3CA, SDHD, ADAM10, BAD, UQCR11, GNAQ, NDUFB4, NDUFAB1, APOE, CALML6, UQCRB, BACE2, NDUFA6, UQCRHL, ITPR3, NDUFA5, UQCRC1, NDUFB5, BID, MAPK1, CACNA1F, UQCRFS1, UQCRC2, PLCB3, COX6A1, GSK3B, NDUFA2, SNCA, APP, ERN1, CAPN2, ATP5PD, GRIN2C, NOS1, CHP2",0.0443122496864942,0.00436480540245009,FALSE +"transcriptomics","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.55987,-1.94,0.00943,17343,0.184,"IARS2, MARS2, FARS2, FARSB, WARS2, RARS2, PSTK, YARS2",2.02548830726267,0.735182176990464,TRUE +"transcriptomics","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.51252,1.51,0.0419,5085,0.448,"HK2, MPI, GMPPA, NANP, GCK, PGM1, GMPPB, NPL, NAGK, GALT, CYB5R1, NANS, FPGT, HK1, GALE, UXS1, CYB5R3, HEXB, GNPDA1, AMDHD2, PGM2",1.3777859770337,0.348721986001856,FALSE +"transcriptomics","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.28452,0.823,0.733,4515,1,"CAT, CCS, CASP1, MAPK13, GRIN1, GRIN2A, GPX1, GRIN2D, CHP1, MAPK11, PPP3CA, BAD, MAP3K5",0.134896025358872,0,FALSE +"transcriptomics","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.26803,0.783,0.821,4719,1,"RFXANK, IFI30, TAPBP, CALR, CD74, CTSS, LGMN, CTSB, HSPA1B, B2M, CIITA, PDIA3, PSME1, CD4",0.0856568428805592,0,FALSE +"transcriptomics","Log2FC","KEGG_APOPTOSIS",0.28433,0.824,0.742,6624,1,"TRADD, IL1RAP, CAPN1, PIK3R2, ENDOD1, IKBKB, PIK3CA, MYD88, FADD, TNFSF10, CASP10, RELA, CHP1, PPP3CA, IRAK4, BAD, ENDOG, PIK3R3, NGF, PRKACA, IL1A, BID, CSF2RB, BAX, PIK3R5, PIK3CB, IL1R1, NFKBIA, PRKAR1B, DFFA, CAPN2, BCL2L1, CHP2",0.129596094720973,0,FALSE +"transcriptomics","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",0.38876,1.11,0.279,2694,0.73,"PLA2G12A, CYP4F3, CYP2E1, PTGES, PLA2G6, GGT7, PLA2G4B, LTC4S, PTGES2, EPHX2, CYP2J2, CYP4A22, PTGS1, PLA2G10, PLA2G4E, ALOX12B",0.554395796726402,0.136677139879544,FALSE +"transcriptomics","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.31866,0.908,0.617,5717,0.975,"GLUL, PYCR3, CKMT1A, CKMT1B, SAT2, NOS3, GLS2, ASL, ASS1, OAT, GATM, P4HA2, NAGS, PRODH, P4HA1, MAOA, AZIN2, ALDH4A1, GAMT",0.209714835966758,0.0109953843014632,FALSE +"transcriptomics","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.3651,1.07,0.358,3482,0.748,"ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, JUP, DSP, ITGA3, CACNB2, DAG1, DSG2, ITGA2B, DSC2, TCF7L1, PKP2",0.446116973356126,0.126098402135539,FALSE +"transcriptomics","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.50501,-1.77,0.0103,14596,0.157,"UGDH, MIOX, ALDH3A2, UGT2A1, ALDH1B1, ALDH7A1, ALDH9A1",1.98716277529483,0.804100347590766,TRUE +"transcriptomics","Log2FC","KEGG_ASTHMA",-0.34369,-1.2,0.212,17122,0.518,"IL13, EPX, IL5",0.673664139071249,0.285670240254767,FALSE +"transcriptomics","Log2FC","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.42092,-1.46,0.0825,16806,0.317,"IFNA21, PRF1, IFNA13, IL5, CTLA4",1.08354605145007,0.498940737782249,FALSE +"transcriptomics","Log2FC","KEGG_AXON_GUIDANCE",0.44776,1.31,0.108,5666,0.756,"EPHA1, PAK6, PLXNB2, EPHB3, PLXNB1, PLXNA3, SEMA4A, EFNA1, FES, SEMA3E, EFNA4, SEMA4B, RAC2, LIMK2, SEMA7A, EFNA3, SRGAP3, MAPK3, NTN4, RHOD, UNC5B, NTN1, PLXNB3, CDK5, EPHB4, MET, PLXNA2, EPHB6, SEMA3B, ABLIM3, NCK2, EPHB2, SEMA4F, SRGAP1, UNC5A, ABLIM2, EFNB3, EFNB1, ABLIM1, SEMA5B, CHP1, PPP3CA, PAK2, SEMA4C, SEMA4D, NGEF, SEMA3C, LIMK1, NCK1, SEMA5A, RASA1, RND1, ROBO3, RAC1, PAK1, PAK4, MAPK1, NFATC1",0.96657624451305,0.121478204498793,FALSE +"transcriptomics","Log2FC","KEGG_BASAL_CELL_CARCINOMA",0.3741,1.08,0.314,4115,0.74,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, WNT4, DVL3, BMP2, WNT10A, GLI3, TCF7L1, FZD4, DVL2, WNT11",0.503070351926785,0.130768280269024,FALSE +"transcriptomics","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.36638,-1.26,0.167,18395,0.512,"TBPL1, TAF9B, TBP, GTF2H2, TAF9, TAF1L",0.777283528852417,0.290730039024169,FALSE +"transcriptomics","Log2FC","KEGG_BASE_EXCISION_REPAIR",0.30931,0.896,0.629,912,0.957,"SMUG1, POLD4, POLB",0.201349354554731,0.0190880622231565,FALSE +"transcriptomics","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.24897,-0.832,0.686,17472,1,"ALDH1B1, ALDH7A1, SMS, ALDH9A1",0.163675884293248,0,FALSE +"transcriptomics","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.30636,0.879,0.673,3986,0.973,"ACOT4, TECR, ACAA1, ELOVL6, ACOX1, SCD5",0.171984935776023,0.0118871597316481,FALSE +"transcriptomics","Log2FC","KEGG_BLADDER_CANCER",0.38783,1.13,0.275,4516,0.72,"CDH1, ERBB2, MMP9, TYMP, VEGFB, MAPK3, EGFR, E2F1, DAPK1, THBS1, FGFR3, BRAF, PGF, VEGFA, DAPK2",0.560667306169737,0.142667503568732,FALSE +"transcriptomics","Log2FC","KEGG_BUTANOATE_METABOLISM",0.28276,0.817,0.752,2472,1,"ABAT, HMGCL, BDH1, HMGCS1, ACADS, EHHADH",0.123782159408358,0,FALSE +"transcriptomics","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.39615,1.16,0.232,6959,0.709,"VAV1, BLNK, PIK3R2, PLCG2, DAPP1, RAC2, VAV3, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, IFITM1, CD72, CD79A, RELA, CD19, CHP1, PPP3CA, LYN, PIK3R3, RAC1, MAPK1, NFATC1, PIK3R5, PIK3AP1, PIK3CB, NFKBIA, GSK3B, FOS, SYK, NFATC4, GRB2, CHP2, INPP5D, BCL10, CD22",0.6345120151091,0.149353764816933,FALSE +"transcriptomics","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.29926,0.866,0.698,4406,0.976,"DRD5, PTAFR, BDKRB2, ERBB2, P2RX4, PLCG2, GNA15, CACNA1D, ERBB3, GRIN1, PLCD1, ATP2A3, CALML3, NOS3, CAMK2G, ADORA2B, ADORA2A, CACNA1I, ADCY4, BDKRB1, RYR1, PTK2B, EGFR, ATP2B4, SLC8A2, GRIN2A, PLCG1, SPHK2, PHKG1, ADRB2, GRIN2D, CHP1, P2RX6, PPP3CA, EDNRA, TNNC1, GNAS, GNAQ, P2RX2, LTB4R2, HTR7",0.156144577376839,0.0105501823333082,FALSE +"transcriptomics","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.27818,0.796,0.785,6162,1,"TNNI3, CACNA1D, CACNG1, COX5B, CACNB3, CACNG4, CACNB2, COX6C, UQCR10, COX6B2, TNNT2, TNNC1, SLC9A1, UQCR11, UQCRB, UQCRHL, UQCRC1, CACNA1F, UQCRFS1, UQCRC2, COX6A1",0.105130343254747,0,FALSE +"transcriptomics","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.37321,1.08,0.333,3535,0.74,"CDH3, NECTIN1, CDH1, CLDN8, ITGB2, CLDN9, CLDN7, CLDN4, F11R, ITGB8, CDH5, SDC1, ICOSLG, SDC4, CLDN18, ICAM3, CD6, GLG1, CLDN11, CD40, SELL, PTPRF, CLDN23, CD276, CLDN3",0.47755576649368,0.130768280269024,FALSE +"transcriptomics","Log2FC","KEGG_CELL_CYCLE",-0.36349,-1.25,0.124,15880,0.493,"ORC1, MCM4, PTTG2, CCNA2, ORC6, SMAD4, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, MCM3, ANAPC10, CDK6, CDC20, CDK1, SMC1A, CCNH, CCNB3, CDKN2C, CDC25A, TGFB1, ORC4, CCNB1, MCM6, PRKDC, TTK, CDC14A, CDKN2B, E2F2, BUB3, ORC2, CDC7, PTTG1, YWHAQ, HDAC2, SMC3, E2F5, ORC3, CDKN2A, E2F3, SMAD2, ANAPC13",0.906578314837765,0.30715308072277,FALSE +"transcriptomics","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.31904,0.929,0.578,4742,0.946,"CCR3, PRKCD, CCL22, STAT2, GRK7, VAV1, PIK3R2, FOXO3, GRK2, CX3CL1, RAC2, VAV3, CCL17, JAK3, CXCL10, IKBKB, MAPK3, CCL28, CCR2, ARRB1, VAV2, CCR7, ADCY5, PIK3CA, ADCY4, CXCL11, CXCL16, CCL5, PTK2B, STAT5B, RAP1A, CXCL9, CXCR2, STAT3, BRAF, ADCY6, RELA, TIAM1, PXN, GNB2, TIAM2, CCL26, CCL19, CXCL3, PRKCZ, CXCR6, WASL, LYN, PIK3R3, STAT1, CCR1",0.238072161579471,0.0241088635982073,FALSE +"transcriptomics","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.24297,0.696,0.913,6797,0.991,"CBLC, BCR, PIK3R2, IKBKB, MAPK3, PIK3CA, STAT5B, E2F1, CBLB, BRAF, CDKN1B, RELA, MECOM, RUNX1, BAD, PIK3R3, TGFB3, CRKL, STAT5A, TGFBR2, MAPK1, PIK3R5, PIK3CB, NFKBIA, CDKN1A, BCL2L1, GRB2, CTBP1, CCND1",0.039529222465701,0.00392634551472468,FALSE +"transcriptomics","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.41491,1.19,0.181,4027,0.722,"BHLHE41, NR1D1, CSNK1E, BHLHE40, PER3",0.742321425130815,0.141462802430361,FALSE +"transcriptomics","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29489,0.861,0.697,7287,0.98,"PC, IDH2, ACO2, IDH3B, SDHD, OGDHL, MDH1, MDH2, OGDH, IDH3G, IDH1, SUCLG2, SDHA",0.156767221901991,0.00877392430750515,FALSE +"transcriptomics","Log2FC","KEGG_COLORECTAL_CANCER",-0.17873,-0.64,1,14592,1,"KRAS, RAF1, LEF1, CASP9, BIRC5, AKT2, MAPK9, BCL2, MSH6, CASP3, MSH3, RHOA, APPL1, APC2, AKT3, SMAD4, PIK3R1, PIK3CG, MSH2, APC, TGFB1, TCF7, MAPK8, AXIN2, SMAD2",0,0,FALSE +"transcriptomics","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.26321,0.774,0.821,6969,1,"BDKRB2, F3, BDKRB1, VWF, FGA, FGG, CFB, PROC, C3, PLAU, CD59, SERPINA5, C2, PLAT, SERPINA1, C9, C1R, CFI, F8, CD55, C4A, SERPINF2, F12, FGB",0.0856568428805592,0,FALSE +"transcriptomics","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.22246,-0.783,0.813,15262,1,"BHMT, ADI1, MTR, CDO1, GOT2, SRM, LDHB, MAT2A, AMD1, SMS, MTAP, TRDMT1",0.0899094544059319,0,FALSE +"transcriptomics","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33412,0.968,0.513,5572,0.862,"CCR3, IFNL3, IFNL1, CSF1R, CCL22, TNFSF13, IFNL2, IL1RAP, CRLF2, TNFRSF21, PDGFA, IL9R, BMP7, CX3CL1, TNFRSF18, CCL17, IL4R, VEGFB, CXCL10, LTBR, CCL28, CCR2, IFNLR1, EPOR, IFNB1, PDGFB, BMP2, CCR7, FLT3LG, MET, CXCL11, CXCL16, CCL5, TNFRSF25, EGFR, CTF1, ACVR1B, IL18, CD40, IL12B, CXCL9, TNFSF10, CXCR2, TNFRSF14, CLCF1, IL7R, EPO, CCL26, IL20RB, IL6R, IL6, NGFR, CCL19, CXCL3, IL20RA, TNFSF18, CXCR6, VEGFA, CSF2, TNFRSF12A, IL15RA, CCR1, LTB, IL12A, IL1R2, PRLR, TGFB3, CSF1, GH2, OSMR, INHBB, IL1A, VEGFC, EDAR, IFNGR1, TGFBR2, CXCL6, IL17RA, CSF2RB",0.289882634888184,0.0644927341752872,FALSE +"transcriptomics","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.36654,1.06,0.35,3908,0.769,"CASP1, MAVS, RIPK3, IRF3, CXCL10, IKBKB, IFNB1, CCL5, DDX58, IL18, PYCARD, RELA, IKBKE, IL6",0.455931955649724,0.114073660198569,FALSE +"transcriptomics","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",0.30112,0.871,0.675,4386,0.973,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ADCY5, ADCY4, ITGA3, CACNB2, DAG1, ITGA2B, ADCY6, TNNT2, TNNC1, GNAS, ITGA2",0.170696227168975,0.0118871597316481,FALSE +"transcriptomics","Log2FC","KEGG_DNA_REPLICATION",-0.44719,-1.54,0.0288,15778,0.294,"DNA2, RFC2, MCM4, RFC5, MCM3, RNASEH1, PRIM1, MCM6, RNASEH2B, PRIM2, POLE3, RFC1, RPA2, POLA1",1.54060751224077,0.531652669587843,FALSE +"transcriptomics","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.4409,1.27,0.123,5751,0.75,"ETV7, ETS2, MAPK3, ETV6, EGFR, NOTCH3, PIWIL2, NOTCH1, MAPK1, SPIRE1, SPIRE2",0.910094888560602,0.1249387366083,FALSE +"transcriptomics","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.47037,1.37,0.0703,3662,0.683,"ADH7, ALDH3B2, GSTK1, CYP2E1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, FMO4, MGST2, CYP2D6, UGT2B17, MGST3",1.15304467498018,0.165579296318467,FALSE +"transcriptomics","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.40437,1.16,0.245,3623,0.709,"XDH, TYMP, NAT1, UCKL1, CES2, UPP1, TK1, CDA, UGT2B17, TPMT, GUSB, ITPA",0.610833915635468,0.149353764816933,FALSE +"transcriptomics","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.39479,1.14,0.244,4629,0.715,"CHAD, LAMA3, ITGB6, LAMB3, ITGB8, SDC1, SDC4, CD47, TNC, LAMC2, GP6, ITGB4, CD44, AGRN, THBS3, VWF, ITGA3, DAG1, THBS1, ITGA2B, COL1A1, LAMA5, LAMB1, ITGA2, COL5A1, HSPG2",0.612610173661271,0.145693958198919,FALSE +"transcriptomics","Log2FC","KEGG_ENDOCYTOSIS",0.41396,1.2,0.183,5701,0.724,"EPN3, CHMP4B, CBLC, PSD4, CSF1R, ITCH, TRAF6, RAB11FIP4, CHMP2B, GRK7, FGFR2, RAB22A, PLD1, ARFGAP1, CHMP2A, GRK2, RAB5B, ARAP1, ERBB3, TFRC, ACAP1, EHD2, PLD2, SMURF1, VPS37C, ARRB1, CHMP5, PRKCI, CHMP3, RAB11FIP1, MET, MVB12A, SH3GLB2, IGF1R, CHMP6, VPS28, ARAP2, PARD6B, EGFR, EPN1, ARFGAP3, VPS37B, FGFR3, LDLRAP1, CXCR2, ARFGAP2, CBLB, EPS15, AP2M1, ADRB2, SRC, HSPA1B, CHMP4C, RAB11FIP5, AGAP1, ACAP2, PRKCZ, AP2A1, NEDD4L, ARAP3, PIP5K1C, STAMBP, CHMP1B, LDLR, ASAP2, HSPA2, IQSEC1, DNM2, RAB11B, RAB31, ARF6, RAB5C, VPS25, STAM2",0.737548910269571,0.140261433802853,FALSE +"transcriptomics","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.26466,0.773,0.846,3392,1,"CDH1, ERBB2, PIK3R2, FOXO3, MAPK3, PIK3CA, EGFR, BRAF, TCF7L1",0.0726296369609765,0,FALSE +"transcriptomics","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.38362,1.12,0.278,6354,0.711,"MAPK13, PLCG2, F11R, ATP6V1C2, ATP6V0D2, ATP6V1B1, ATP6V1F, IKBKB, MET, CCL5, EGFR, ATP6AP1, CXCR2, PLCG1, RELA, SRC, MAPK11, NOD1, ADAM10, TCIRG1, LYN, ATP6V1G1, ATP6V0A4, RAC1, PAK1, MAPK10, ATP6V1C1, NFKBIA, TJP1, ATP6V1E1, IGSF5",0.555955204081924,0.148130399270234,FALSE +"transcriptomics","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.39525,1.16,0.229,5894,0.709,"GAB1, PAK6, CBLC, ERBB2, PIK3R2, PLCG2, ERBB3, CAMK2G, MAPK3, RPS6KB2, PIK3CA, NCK2, EGFR, STAT5B, BTC, CBLB, BRAF, PLCG1, CDKN1B, SRC, TGFA, PAK2, AREG, BAD, PIK3R3, NCK1, CRKL, STAT5A, PAK1, PAK4, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB",0.640164517660112,0.149353764816933,FALSE +"transcriptomics","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.38786,1.12,0.276,3971,0.711,"PLA2G12A, PLD1, PLA2G6, PLA2G4B, PLD2, LPCAT2, PLA2G10, PLA2G4E, PLPP3, LPCAT4, PLA2G2C",0.559090917934782,0.148130399270234,FALSE +"transcriptomics","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.38078,1.1,0.3,3627,0.737,"ADH7, ACAA1, CPT1B, GCDH, CYP4A22, ACSL1, CPT2, CPT1C, ACADS, EHHADH, ACOX1, ACSL3",0.522878745280338,0.132532512140949,FALSE +"transcriptomics","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.33886,0.976,0.483,2596,0.858,"PRKCD, PLA2G12A, VAV1, MAPK13, PIK3R2, PLCG2, RAC2, VAV3, PLA2G6, PLA2G4B, MAPK3, VAV2, PIK3CA, PLA2G10, PLA2G4E",0.316052869248488,0.0665127121512946,FALSE +"transcriptomics","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.40295,1.17,0.217,5894,0.738,"PRKCD, VAV1, PLD1, PIK3R2, PLCG2, RAC2, VAV3, LIMK2, PLA2G6, PLA2G4B, PLA2G4F, PLD2, MAPK3, RPS6KB2, VAV2, MARCKS, GSN, PIK3CA, PLA2G4E, PLCG1, PLPP3, SPHK2, WASL, LYN, PIK3R3, PIP5K1C, SPHK1, LIMK1, CRKL, SCIN, ASAP2, MYO10, DNM2, RAC1, PAK1, ARF6, MAPK1, PIK3R5, PIK3CB",0.66354026615147,0.131943638176958,FALSE +"transcriptomics","Log2FC","KEGG_FOCAL_ADHESION",0.30588,0.898,0.614,6359,0.962,"PAK6, CHAD, ERBB2, LAMA3, VAV1, ITGB6, PDGFA, PIK3R2, LAMB3, ITGB8, RAC2, VAV3, VEGFB, TNC, LAMC2, ITGB4, MAPK3, PPP1CA, VAV2, PDGFB, PIK3CA, PPP1CB, MET, IGF1R, THBS3, VWF, PDGFD, ITGA3, EGFR, RAP1A, THBS1, ITGA2B, BRAF, CAV2, PXN, COL1A1, SRC, CAV1, MYL9, ARHGAP35, PAK2, LAMA5, BAD, PGF, LAMB1, ITGA2, COL5A1, VEGFA, RASGRF1, PIK3R3, PIP5K1C, CRKL, MYL7, ARHGAP5, VEGFC, RAC1, PAK1, BCAR1, PAK4, MAPK1, MAPK10, PIK3R5, PIK3CB, PTEN, COL1A2, ITGA5, TLN2, GSK3B, COL6A1, DIAPH1, ITGA4, CAPN2",0.211831628858832,0.0168249279621871,FALSE +"transcriptomics","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.42522,1.24,0.159,5764,0.729,"ALPP, QDPR, SPR, FPGS",0.798602875679548,0.137272471682025,FALSE +"transcriptomics","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.5816,1.68,0.0112,3752,0.315,"ALDOC, PFKFB2, HK2, MPI, GMPPA, FBP1, GMPPB, PFKL, FBP2, MTMR1, FPGT, HK1, PFKFB4, ALDOA",1.95078197732982,0.501689446210399,FALSE +"transcriptomics","Log2FC","KEGG_GALACTOSE_METABOLISM",0.52612,1.53,0.0321,3636,0.436,"HK2, GCK, GAA, PGM1, PFKL, B4GALT1, GALT, GANC, HK1, B4GALT2, GLB1, GALE",1.49349496759513,0.360513510731414,FALSE +"transcriptomics","Log2FC","KEGG_GAP_JUNCTION",-0.17017,-0.602,0.99,15556,0.985,"ADRB1, TUBB3, ITPR2, MAP2K5, ADCY7, PRKX, TUBA1B, TUBB, GNAI1, ITPR1, TUBAL3, PRKACB, CDK1, PLCB4, PDGFRA, TUBA1A, NRAS, TUBB4A, TUBB2B, TUBB2A",0.00436480540245009,0.00656376950238827,FALSE +"transcriptomics","Log2FC","KEGG_GLIOMA",0.26293,0.77,0.86,3686,1,"PDGFA, PIK3R2, PLCG2, CALML3, CAMK2G, MAPK3, PDGFB, PIK3CA, IGF1R, EGFR, E2F1, BRAF, PLCG1, TGFA",0.0655015487564323,0,FALSE +"transcriptomics","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.33643,0.982,0.462,4600,0.85,"GSTK1, GGT7, GSTT2, GSTO2, GSS, IDH2, GSTZ1, GSTA3, OPLAH, MGST2, GGT6, GPX1, MGST3, ANPEP, G6PD, GPX3",0.335358024443874,0.0705810742857073,FALSE +"transcriptomics","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.17981,0.517,0.998,5968,0.997,"DGKA, LIPG, DGAT1, MGLL, TKFC, PLPP3, CEL, DGKH, AGPAT2, PNPLA3, DGKI, AWAT2, MBOAT1, DGKE",0.000869458712628891,0.00130484168834428,FALSE +"transcriptomics","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.36747,1.08,0.348,5053,0.74,"PISD, CDS1, PLA2G12A, CHKB, DGKA, PLD1, PLA2G6, PLA2G4B, PLD2, PCYT2, CHKA, LPCAT2, ETNK2, CDS2, PLA2G10, PLA2G4E, PLPP3, MBOAT7, LPCAT4, PLA2G2C, DGKH, AGPAT2, PGS1, LPCAT3, LYPLA2, ACHE, PCYT1A, DGKI",0.458420756053419,0.130768280269024,FALSE +"transcriptomics","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.31093,0.903,0.626,6983,0.968,"AGXT, GCAT, AOC2, GATM, SARDH, SHMT1, MAOA, AMT, GAMT, CTH, SDS, GNMT, AOC3, ALAS2, SRR",0.20342566678957,0.0141246426916063,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.4334,1.25,0.141,1880,0.742,"LDHC, ADH7, ACSS2, ALDH3B2, ALDOC, HK2, ALDH1A3, GCK, ALDH3B1, FBP1, PGM1, GALM, PFKL",0.85078088734462,0.129596094720973,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.43624,1.27,0.142,4160,0.75,"B4GALT7, CHPF, CHST12, XYLT2, CHST14, XYLT1, CHPF2, CHST11, CHST15",0.847711655616944,0.1249387366083,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.45434,1.32,0.113,3529,0.756,"B4GALT7, EXT1, HS3ST1, XYLT2, HS6ST1, NDST1, HS6ST2, XYLT1",0.94692155651658,0.121478204498793,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66703,1.94,0.00221,3600,0.275,"B3GNT7, CHST6, B4GALT4, B4GALT1, B3GNT2, CHST4, ST3GAL1, B4GALT2",2.65560772631489,0.560667306169737,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.5591,1.63,0.0157,4196,0.327,"HGSNAT, NAGLU, HPSE, HYAL4, IDS, GALNS, HYAL2, GUSB, GLB1, HEXB",1.80410034759077,0.485452247339714,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.42593,1.23,0.161,6306,0.72,"ST6GALNAC5, B3GALT4, SLC33A1, ST3GAL1, GLB1, HEXB, ST6GALNAC6, ST6GALNAC4, HEXA, ST8SIA1",0.79317412396815,0.142667503568732,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.58271,1.69,0.0158,4276,0.354,"FUT2, FUT1, NAGA, B3GALNT1, ST3GAL1, GBGT1, A4GALT, HEXB, B3GALT5",1.80134291304558,0.450996737974212,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.59777,1.73,0.011,3600,0.325,"B3GNT3, ABO, FUT3, FUT2, B4GALT4, B3GNT5, B3GNT4, B4GALT1, FUT1, B3GNT2, ST3GAL4, B4GALT2",1.95860731484178,0.488116639021126,FALSE +"transcriptomics","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.50004,1.46,0.0477,3611,0.549,"PIGT, PIGU, GPAA1, PIGZ, PIGV, PIGQ, PIGL, PIGX, PIGS",1.32148162095989,0.260427655549908,FALSE +"transcriptomics","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.50461,-1.78,0.0202,16224,0.189,"HYI, MTHFD2L, MTHFD2, ACO1, CS, MTHFD1L, HAO2",1.69464863055338,0.723538195826756,TRUE +"transcriptomics","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.34964,1.01,0.424,2596,0.816,"PRKCD, PLA2G12A, MAPK13, PLD1, CACNA1D, PLA2G6, CALML3, PLA2G4B, MAP3K4, PLD2, CAMK2G, MAPK3, MAP3K1, ADCY5, CGA, ADCY4, MMP14, PTK2B, PLA2G10, EGFR, PLA2G4E",0.372634143407267,0.0883098412461389,FALSE +"transcriptomics","Log2FC","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.20626,-0.679,0.865,3907,1,"IL6, IL1A, KLRC1, KIR2DL1, IL1B, KIR2DL3, KIR3DL2, CD86, FAS, CD80, IFNG, CD28, TNF, KLRD1, GZMB, FASLG, IL2, PRF1",0.0629838925351858,0,FALSE +"transcriptomics","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.36379,1.07,0.331,2621,0.748,"WNT3A, WNT9A, WNT7B, BMP7, WNT7A, WNT4, BMP2, CSNK1E, WNT10A, CSNK1A1, GLI3",0.480172006224281,0.126098402135539,FALSE +"transcriptomics","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.38485,1.12,0.283,6109,0.711,"CSF1R, IL9R, IL4R, TFRC, EPOR, FLT3LG, CD44, ITGA3, CD9, ITGA2B, CD19, IL7R, EPO, IL6R, IL6, ANPEP, CD59, ITGA2, CSF2, CD4, IL1R2, CSF1, IL1A, IL1R1, CD1D, CD55, ITGA5",0.54821356447571,0.148130399270234,FALSE +"transcriptomics","Log2FC","KEGG_HISTIDINE_METABOLISM",0.35152,1.02,0.419,1584,0.807,"ALDH3B2, HEMK1, HAL, ALDH1A3, ALDH3B1",0.377785977033705,0.0931264652779296,FALSE +"transcriptomics","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",0.23381,0.677,0.93,764,0.995,"POLD4, SEM1",0.0315170514460649,0.00217691925427455,FALSE +"transcriptomics","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.17121,-0.608,0.99,16664,1,"ITPR1, NDUFS4, BBC3, AP2S1, SOD1, COX6B1, COX7A2, DCTN4, AP2A2, PLCB4, ATP5F1C, NDUFA9, VDAC2, POLR2E, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, HDAC2, HIP1, TBPL1, TBP, UCP1, ATP5F1A, POLR2D, BDNF, NDUFS5, TFAM, GRIN2B",0.00436480540245009,0,FALSE +"transcriptomics","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.30969,0.899,0.622,4437,0.969,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ITGA3, CACNB2, DAG1, ITGA2B, PRKAA1, ACE, TNNT2, IL6, TNNC1, ITGA2, PRKAG2",0.206209615309181,0.0136762229492347,FALSE +"transcriptomics","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.30094,0.872,0.682,6116,0.98,"PLCG2, INPP4B, PLCD1, INPP4A, ALDH6A1, PIK3CA, PIP4K2C, PLCG1, PIK3C2G, PIK3C2B, INPP5K, IMPA2, PIP5K1C, INPPL1, INPP5J, ISYNA1, PIK3CB, PTEN, PLCB3, IPMK",0.166215625343521,0.00877392430750515,FALSE +"transcriptomics","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.32542,0.95,0.513,6911,0.894,"CBLC, PPP1R3D, HK2, PTPN1, PIK3R2, GYS1, CALML3, SOCS1, MKNK1, GCK, IKBKB, MAPK3, RPS6KB2, FBP1, INSR, PPP1CA, SH2B2, PIK3CA, PPP1CB, PRKCI, TSC1, FBP2, IRS2, PTPRF, CBLB, BRAF, PRKAA1, PHKG1, HK1, FOXO1, PRKCZ, BAD, PRKAG2, INPP5K, EXOC7, PIK3R3, FASN, PYGL, CALML6, CRKL, PRKAB2, PRKACA, RHEB, PPP1R3B, MAPK1, FLOT2, MAPK10, PIK3R5, IRS1, PIK3CB, PRKAR1B, GSK3B, PHKG2, TRIP10, GRB2, INPP5D, PYGB, PRKAG1, TSC2, RPTOR",0.289882634888184,0.0486624812040823,FALSE +"transcriptomics","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.3125,0.906,0.613,3908,0.97,"TNFSF13, ICOSLG, LTBR, CCL28, CD40, PIGR, IL6",0.212539525481585,0.0132282657337552,FALSE +"transcriptomics","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.33678,0.989,0.466,5894,0.849,"IFNL3, IFNL1, CBLC, STAT2, IFNL2, CRLF2, PIK3R2, IL9R, IRF9, JAK3, IL4R, SOCS1, CISH, IFNLR1, EPOR, PTPN6, IFNB1, PIK3CA, TYK2, EP300, STAT6, CTF1, STAT5B, IL12B, CBLB, STAT3, CLCF1, IL7R, EPO, IL20RB, IL6R, IL6, PIAS3, IL20RA, PIM1, CSF2, PIK3R3, SPRY1, IL15RA, STAT1, IL12A, PRLR, GH2, STAT5A, OSMR, IFNGR1, JAK1, CSF2RB, STAM2, PIK3R5, PIK3CB",0.33161408331,0.0710923097560473,FALSE +"transcriptomics","Log2FC","KEGG_LEISHMANIA_INFECTION",0.42556,1.23,0.151,6358,0.72,"TRAF6, ITGB2, NCF4, MAPK13, MAPK3, PTPN6, MYD88, IL12B, TAB1, RELA, MAPK11, C3, TLR2, IRAK4, STAT1, IL12A, TGFB3, IL1A, IFNGR1, JAK1, TAB2, MAPK1, NFKBIA, FOS, ITGA4",0.821023052706831,0.142667503568732,FALSE +"transcriptomics","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.41873,1.2,0.198,3793,0.724,"CTNND1, CLDN8, ITGB2, MMP9, CLDN9, VAV1, NCF4, CLDN7, MAPK13, PIK3R2, PLCG2, CLDN4, F11R, CDH5, RAC2, VAV3, VAV2, CLDN18, PIK3CA, RASSF5, PTK2B, RAP1A, CLDN11, RAPGEF3, PLCG1, SIPA1, PXN, CLDN23, CLDN3, MYL9, MAPK11, ARHGAP35",0.703334809738469,0.140261433802853,FALSE +"transcriptomics","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.42081,-1.48,0.0769,15341,0.33,"ALDH3A2, HADHA, YOD1, ALDH1B1, ALDH7A1, ALDH9A1",1.11407366019857,0.481486060122112,FALSE +"transcriptomics","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",0.40266,1.16,0.259,2596,0.709,"PLA2G12A, CYP2E1, PLA2G6, PLA2G4B, CYP2J2, PLA2G10, PLA2G4E",0.586700235918748,0.149353764816933,FALSE +"transcriptomics","Log2FC","KEGG_LONG_TERM_DEPRESSION",0.24312,0.708,0.903,6599,1,"PLA2G12A, GNAO1, PLA2G6, PLA2G4B, MAPK3, IGF1R, RYR1, PLA2G10, PLA2G4E, BRAF, PLA2G2C, GNAS, GNAQ, LYN, ITPR3, MAPK1, PLCB3, PPP2R1A, GUCY1A1, NOS1, PLA2G2F, GUCY1B1, GNA12",0.0443122496864942,0,FALSE +"transcriptomics","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.23447,0.676,0.938,5774,0.988,"GRIN1, CALML3, CAMK2G, MAPK3, PPP1CA, PPP1CB, EP300, RAP1A, RAPGEF3, GRIN2A, BRAF, GRIN2D, CHP1, PPP3CA, GNAQ, RPS6KA2, CALML6, ITPR3, PRKACA, MAPK1, RPS6KA1",0.0277971616209356,0.00524305541237188,FALSE +"transcriptomics","Log2FC","KEGG_LYSINE_DEGRADATION",0.22598,0.643,0.957,2472,0.999,"BBOX1, KMT5B, KMT5C, GCDH, AASDH, EHHADH",0.0190880622231565,0.000434511774017692,FALSE +"transcriptomics","Log2FC","KEGG_LYSOSOME",0.52683,1.54,0.0398,5277,0.452,"CTSH, GM2A, CTSA, CTSV, HGSNAT, SLC11A1, NAGLU, GGA2, CTSD, ARSA, ATP6V0D2, LIPA, DNASE2, ABCB9, SUMF1, GAA, MANBA, NPC1, NAGA, ACP5, PSAP, IDS, GNPTG, NPC2, AP1M2, GALNS, CTSS, LAPTM4A, NAPSA, AP1B1, AP3M2, GGA1, LGMN, NEU1, TPP1, ATP6AP1, PSAPL1, ASAH1, LAMP3, CD68, CTSB, LAMP1, CLN5, GUSB, GLB1, GGA3, AP3S2, LAMP2, FUCA1, NAGPA, SCARB2, CTSE, HEXB, PPT1, AP1S1, TCIRG1, MAN2B1, CD63, SLC11A2, MFSD8, ABCA2, CTSZ, SORT1, AP1S3, ATP6V0A4, ENTPD4, GBA",1.40011692792631,0.344861565188618,FALSE +"transcriptomics","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",0.26798,0.764,0.837,5856,0.998,"NTF4, PLA2G12A, TRAF6, FGF11, FGFR2, MAPK13, PDGFA, CACNA1D, RAC2, CACNG1, PLA2G6, PLA2G4B, MAP3K4, MKNK1, DUSP9, CACNB3, HSPB1, CACNG4, IKBKB, MAPK3, ARRB1, MAP4K1, MAP3K1, PDGFB, CACNA1I, FGF1, DUSP3, MAPK8IP2, MAX, NTRK2, PLA2G10, EGFR, CACNB2, PLA2G4E, MAP3K11, MAPKAPK3, RAP1A, JUND, ECSIT, MAP3K6, TAB1, LAMTOR3, FGFR3, MAP3K13, TAOK3, BRAF, DUSP10, RELA, STK3, DUSP14, CHP1, HSPA1B, MAPK11, PPP3CA, PAK2, PLA2G2C, MECOM, MAP3K8, GADD45B, RASGRF1, FGF12, MAP4K2, MAP3K5, RPS6KA2, IL1R2, RASA1, RPS6KA4, MAPKAPK2, NF1, STK4, TGFB3, CRKL, PPM1A, HSPA2, NGF, PRKACA, IL1A, RAC1, PAK1, MAP4K3, TGFBR2, RRAS, TAB2, MAPK1, DUSP8, MAP2K7, NLK, GADD45A, RPS6KA1, MAPK10, MAPK8IP3, CACNA1F",0.07727454200674,0.000869458712628891,FALSE +"transcriptomics","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26478,0.765,0.837,1432,1,"HES1, GCK",0.07727454200674,0,FALSE +"transcriptomics","Log2FC","KEGG_MELANOGENESIS",0.36219,1.05,0.368,6175,0.756,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, GNAO1, CALML3, WNT4, DVL3, CAMK2G, MAPK3, ADCY5, WNT10A, ADCY4, EP300, ADCY6, TCF7L1, FZD4, CREB3L4, DVL2, WNT11, GNAS, GNAQ, CALML6, CREB3L3, MITF, PRKACA, ASIP, CREB3L2, MAPK1, EDN1, CREB3L1, WNT5A, PLCB3, FZD6, GSK3B",0.434152181326482,0.121478204498793,FALSE +"transcriptomics","Log2FC","KEGG_MELANOMA",-0.26432,-0.944,0.509,16564,0.82,"PIK3R1, PIK3CG, FGF20, CDK6, FGF21, FGF2, PDGFRA, E2F2, NRAS, IGF1, FGF9, FGF4, CDKN2A, FGF5, FGFR1, E2F3, FGF19, FGF3",0.293282217663241,0.0861861476162833,FALSE +"transcriptomics","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.45636,1.33,0.1,3662,0.798,"ADH7, ALDH3B2, GSTK1, DHDH, CYP2E1, CYP1B1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, MGST2, UGT2B17, MGST3",1,0.0979971086492706,FALSE +"transcriptomics","Log2FC","KEGG_MISMATCH_REPAIR",-0.32549,-1.12,0.269,15319,0.652,"MSH6, RFC3, MSH3, RFC2, RFC5, EXO1, MSH2, RFC1, RPA2",0.570247719997592,0.18575240426808,FALSE +"transcriptomics","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.35512,1.01,0.429,6050,0.816,"PIK3R2, VEGFB, MAPK3, RPS6KB2, PIK3CA, TSC1, CAB39, RICTOR, BRAF, PRKAA1, PGF, VEGFA, PIK3R3, HIF1A, RPS6KA2, DDIT4, VEGFC, RHEB, MAPK1, RPS6KA1, PIK3R5, PIK3CB, ULK1",0.367542707815276,0.0883098412461389,FALSE +"transcriptomics","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.2602,0.755,0.852,6624,0.987,"ITGB2, VAV1, PIK3R2, PLCG2, RAC2, VAV3, RAET1L, MAPK3, PTPN6, VAV2, IFNB1, PIK3CA, SH3BP2, PTK2B, TNFSF10, BRAF, PLCG1, CHP1, PPP3CA, LCK, CSF2, PIK3R3, ULBP2, RAC1, IFNGR1, PAK1, BID, MAPK1, NFATC1, PIK3R5, PIK3CB, SYK, NFATC4, HCST, GRB2, CHP2",0.0695604052332999,0.00568284733036327,FALSE +"transcriptomics","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.21335,0.617,0.972,5100,0.992,"DRD5, P2RY2, VIPR2, PTAFR, BDKRB2, P2RY6, P2RX4, LPAR2, VIPR1, S1PR4, THRB, GRIN1, NPBWR1, ADORA1, ADORA2B, ADORA2A, GIPR, S1PR2, GALR3, CGA, BDKRB1, GHSR, GABRP, F2RL3, GRIN2A, OPRL1, CHRNB4, MLNR, S1PR5, ADRB2, GRIN2D, P2RX6, EDNRA, F2RL1, MC3R, P2RX2, LTB4R2, HTR7, CHRNB1, ADRA2A, GRIN3B, GRM4, LTB4R, PRLR, ADRA2B, GH2",0.0123337350737254,0.00348832784582135,FALSE +"transcriptomics","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.33316,0.971,0.508,5975,0.863,"GAB1, NTF4, PRKCD, TRAF6, MAPK13, PIK3R2, PLCG2, FOXO3, CALML3, ARHGDIB, IKBKB, CAMK2G, MAPK3, MAP3K1, SH2B2, PIK3CA, NTRK2, RAP1A, IRS2, TP73, BRAF, PLCG1, YWHAB, RELA, MAPK11, NGFR, IRAK4, BAD, YWHAZ, MAP3K5, PIK3R3, YWHAH, RPS6KA2, SORT1, CALML6, RPS6KA4, MAPKAPK2, CRKL, NGF, RAC1, BAX, MAPK1, MAP2K7, RPS6KA1, MAPK10, PIK3R5, IRS1, PIK3CB, NFKBIA",0.294136287716081,0.0639892042847904,FALSE +"transcriptomics","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.264,0.756,0.833,4274,0.994,"QPRT, NMRK1, NADSYN1, NADK, NT5C1B",0.0793549985932124,0.00261361560268669,FALSE +"transcriptomics","Log2FC","KEGG_NITROGEN_METABOLISM",0.31831,0.918,0.592,2116,0.957,"GLUL, HAL, GLS2, CA9",0.22767829327708,0.0190880622231565,FALSE +"transcriptomics","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.34339,0.991,0.45,4477,0.853,"CASP1, TRAF6, MAPK13, TAB3, IKBKB, MAPK3, TRIP6, CCL5, IL18, PYCARD, TAB1, RELA, CARD6, MAPK11, IL6, NOD1, NOD2, PSTPIP1, NLRP1",0.346787486224656,0.069050968832477,FALSE +"transcriptomics","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.55072,-1.94,0,17605,0.184,"RAD50, PRKDC, NHEJ1, XRCC5",Inf,0.735182176990464,TRUE +"transcriptomics","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.34338,0.987,0.455,3686,0.845,"ERBB2, RXRA, PIK3R2, PLCG2, FOXO3, MAPK3, PIK3CA, RASSF5, RXRB, EGFR, E2F1, BRAF, PLCG1, TGFA",0.341988603342888,0.0731432910503077,FALSE +"transcriptomics","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.39588,1.15,0.236,5482,0.711,"DTX4, HES1, DVL3, DTX3L, JAG1, DTX2, RFNG, EP300, DLL1, LFNG, NOTCH3, APH1A, MFNG, DVL2, JAG2, NUMB, NOTCH1, KAT2A, HES5",0.627087997029893,0.148130399270234,FALSE +"transcriptomics","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.30853,-1.09,0.275,15978,0.584,"RFC2, XPC, RFC5, GTF2H1, XPA, GTF2H3, ERCC3, CUL4A, ERCC8, CCNH, ERCC1, POLE3, RFC1, RPA2, GTF2H2",0.560667306169737,0.233587152887601,FALSE +"transcriptomics","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.39086,1.13,0.257,3600,0.72,"MAN1B1, RPN2, ALG12, ALG3, DPM1, MOGS, MGAT4A, MGAT1, B4GALT1, MGAT5B, STT3A, ALG2, B4GALT2",0.590066876668705,0.142667503568732,FALSE +"transcriptomics","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",0.24959,0.716,0.904,7709,1,"OR4C6, OR10H2, OR2J3, OR11H4, OR8A1, OR2A12, OR2D3, GUCY2D, CALML3, OR8B8, CAMK2G, CLCA2, OR1G1, OR2A7, OR13H1, OR1I1, OR13D1, CNGB1, OR1F1, OR8G5, OR8G1, OR10A3, OR1M1, OR6Q1, OR1K1, OR5P2, OR10H1, OR10A4, OR4D2, OR2A2, CNGA4, OR52B4, CALML6, OR2D2, OR2B2, OR1J1, OR6B1, PRKACA, OR2A14, GUCA1B, OR52K1, OR9A2, OR10A6, OR4L1, OR10AD1, OR2S2, OR10S1, OR10A2, OR2A5, OR10K2, OR10A5, OR8S1, OR4X2, OR5P3, ADCY3, OR6C70, OR8D2, OR8B4, OR2L2, CAMK2D, OR10G3, PRKG2, OR4K1, PRKACG, GRK3, OR8D1, OR52I1, OR6A2",0.0438315695246367,0,FALSE +"transcriptomics","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.44426,-1.56,0.0566,14974,0.314,"DHFR, SHMT2, MTHFS, MTR, MTHFD2L, GART, MTHFD2, MTHFD1L, TYMS, ATIC",1.24718356881173,0.503070351926785,FALSE +"transcriptomics","Log2FC","KEGG_OOCYTE_MEIOSIS",-0.25168,-0.835,0.685,15742,1,"ITPR2, PPP2R5D, PPP3CC, ADCY7, PPP2R5C, PRKX, RPS6KA3, PTTG2, PPP2CB, PPP2R1B, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, ITPR1, ANAPC10, FBXO5, CDC20, PRKACB, PPP3R1, CDK1, SMC1A, CALM2, CCNB1, FBXO43, CPEB1, AR, PTTG1, YWHAQ, SGO1, SMC3, IGF1, PPP1CC, ANAPC13",0.164309428507574,0,FALSE +"transcriptomics","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",0.61199,1.77,0.01,5940,0.328,"MANBA, NEU1, ENGASE, MAN2B2, MAN2C1, GLB1, FUCA1, HEXB, MAN2B1, GBA, HEXA, AGA",2,0.484126156288321,FALSE +"transcriptomics","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",0.23049,0.663,0.951,6376,0.992,"NDUFV1, LHPP, ATP6V1C2, COX5B, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP5F1E, NDUFB7, NDUFS8, NDUFA3, NDUFV2, ATP6AP1, COX6C, UQCR10, COX6B2, SDHD, UQCR11, TCIRG1, NDUFB4, NDUFAB1, ATP6V1G1, UQCRB, ATP6V0A4, NDUFA6, UQCRHL, NDUFA5, UQCRC1, NDUFB5, COX15, ATP5MG, UQCRFS1, ATP6V1C1, UQCRC2, COX6A1, ATP6V1E1, NDUFA2, COX17, ATP5PD",0.0218194830625861,0.00348832784582135,FALSE +"transcriptomics","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.49419,1.43,0.0603,4056,0.601,"GALNT12, GALNT3, GALNT7, GALNT6, B4GALT5, GCNT1, ST6GALNAC1, GCNT3, C1GALT1, GALNT15, ST3GAL1, GALNT11, GALNT9, B3GNT6",1.21968268785985,0.22112552799726,FALSE +"transcriptomics","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.1914,0.553,0.991,5981,0.999,"TP53AIP1, CCNG2, CD82, SERPINB5, SFN, THBS1, TP73, ATR, PERP, SHISA5, EI24, GADD45B, ZMAT3, CCNE1, SIAH1, PIDD1, BID, IGFBP3, BAX, CHEK2, GADD45A, PTEN",0.00392634551472468,0.000434511774017692,FALSE +"transcriptomics","Log2FC","KEGG_PANCREATIC_CANCER",0.34675,0.997,0.453,5894,0.846,"ERBB2, PLD1, PIK3R2, RALB, RAC2, VEGFB, IKBKB, MAPK3, RALGDS, PIK3CA, EGFR, E2F1, RALBP1, STAT3, BRAF, RELA, TGFA, BAD, PGF, VEGFA, PIK3R3, STAT1, TGFB3, RALA, VEGFC, RAC1, JAK1, TGFBR2, MAPK1, MAPK10, PIK3R5, PIK3CB",0.343901797987168,0.0726296369609765,FALSE +"transcriptomics","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.31788,0.923,0.587,8542,0.953,"PANK2, PPCS, ENPP1, COASY, UPB1, PPCDC, BCAT2, DPYD, VNN2",0.231361898752386,0.0209070993616736,FALSE +"transcriptomics","Log2FC","KEGG_PARKINSONS_DISEASE",-0.18037,-0.634,0.965,17631,1,"UBE2J2, ATP5F1C, NDUFA9, VDAC2, LRRK2, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, UCHL1, ATP5F1A, SLC18A2, PARK7, NDUFS5",0.0154726866562074,0,FALSE +"transcriptomics","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.30571,-1.1,0.25,18248,0.625,"YWHAQ, TUBA1A, NCL, ROCK2, TUBB4A, ARHGEF2, TUBB2B, TUBB2A",0.602059991327962,0.204119982655925,FALSE +"transcriptomics","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.2849,0.825,0.772,5981,1,"WNT3A, WNT9A, CBLC, CSF1R, WNT7B, CDH1, ERBB2, FZD10, LAMA3, TRAF6, FGF11, MMP9, RXRA, BCR, FGFR2, TRAF4, PLD1, PDGFA, PIK3R2, PLCG2, RALB, LAMB3, EGLN3, WNT7A, RAC2, WNT4, VEGFB, LAMC2, DVL3, IKBKB, MAPK3, RALGDS, PML, PDGFB, RARA, BMP2, FLT3LG, PIK3CA, JUP, RASSF5, WNT10A, FADD, RXRB, MET, IGF1R, FGF1, MAX, ITGA3, EP300, EGFR, GLI3, STAT5B, E2F1, DAPK1, RALBP1, FGFR3, ITGA2B, PPARG, CBLB, ARNT2, STAT3, BRAF, PLCG1, CDKN1B, RELA, TCF7L1, FZD4, TGFA, FOXO1, IL6, DVL2, MECOM, LAMA5, WNT11, RUNX1, BAD, PGF, PIAS3, LAMB1, EPAS1, ITGA2, VEGFA, FGF12, DAPK2, PIK3R3, HIF1A, STAT1, CCNA1, CCNE1, STK4, TGFB3, CRKL, PTCH1, RALA, MITF, SLC2A1, STAT5A, VEGFC, RAC1, JAK1, BID, TGFBR2, BAX, MAPK1, WNT5A, MAPK10, PIK3R5, TFG, PIK3CB, CEBPA, NFKBIA, PTEN",0.112382699664264,0,FALSE +"transcriptomics","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.47895,1.39,0.0806,4741,0.652,"DHDH, UGT2B17, GUSB, RPEL1, DCXR",1.09366495819491,0.18575240426808,FALSE +"transcriptomics","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.43515,1.26,0.143,5085,0.73,"PGLS, ALDOC, FBP1, PGM1, PFKL, FBP2, ALDOA, H6PD, G6PD, RPEL1, RBKS, DERA, PGM2",0.844663962534938,0.136677139879544,FALSE +"transcriptomics","Log2FC","KEGG_PEROXISOME",0.42548,1.24,0.154,5270,0.729,"CAT, ACOT8, GSTK1, PRDX5, PEX11A, XDH, PXMP4, ACAA1, MVK, AGXT, PEX11G, PEX2, HMGCL, EPHX2, PAOX, IDH2, ACSL1, EHHADH, PEX11B, CROT, ABCD1, ACOX1, ACSL3, PEX10, PEX13, PEX26, SCP2, PEX7, MLYCD, SLC25A17, ABCD4, PEX1, ACSL5, ACSL6",0.812479279163537,0.137272471682025,FALSE +"transcriptomics","Log2FC","KEGG_PHENYLALANINE_METABOLISM",0.40531,1.17,0.206,5148,0.738,"ALDH3B2, ALDH1A3, ALDH3B1, AOC2, NAA80, IL4I1, TAT, MAOA, MIF",0.686132779630847,0.131943638176958,FALSE +"transcriptomics","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.30436,0.88,0.655,6064,0.98,"CDS1, DGKA, PIK3R2, PLCG2, INPP4B, PLCD1, CALML3, INPP4A, PIK3CA, PIP4K2C, CDS2, PLCG1, PIK3C2G, PIK3C2B, DGKH, INPP5K, IMPA2, PIK3R3, PIP5K1C, CALML6, DGKI, ITPR3, INPPL1, INPP5J, PIK3R5, PIK3CB, DGKE, PTEN, PLCB3",0.183758700008217,0.00877392430750515,FALSE +"transcriptomics","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.31034,0.889,0.63,4098,0.966,"ALAD, CP, HMOX2, FTH1, UGT2B17, MMAB, GUSB, HMBS",0.200659450546418,0.0150228735845067,FALSE +"transcriptomics","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.41424,1.19,0.21,5270,0.722,"RXRA, ACAA1, CPT1B, PPARA, PLIN1, CYP4A22, FABP6, ACSL1, RXRB, CPT2, CPT1C, EHHADH, SLC27A6, PLTP, SLC27A1, PPARG, ACOX1, ACSL3, SCD5, SLC27A4, SCP2, OLR1, ACSL5, ACSL6",0.677780705266081,0.141462802430361,FALSE +"transcriptomics","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.20209,-0.718,0.886,14148,1,"ACOX2, HSD17B4, CYP7A1, HSD3B7, AKR1C4, CYP39A1, BAAT",0.0525662781129492,0,FALSE +"transcriptomics","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",0.5701,1.64,0.0143,4719,0.352,"RFXANK, BLNK, RAG1, JAK3, CD40, ADA, CD79A, RAG2, CD19, IL7R, CIITA, LCK, CD4",1.84466396253494,0.453457336521869,FALSE +"transcriptomics","Log2FC","KEGG_PRION_DISEASES",0.24524,0.717,0.885,5622,1,"MAPK3, CCL5, IL6, NOTCH1, PRKACA, IL1A, C9, BAX, MAPK1, EGR1",0.0530567293021746,0,FALSE +"transcriptomics","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28022,-1.01,0.396,15860,0.714,"ADCY7, PRKX, RPS6KA3, CCNA2, AKT3, MAD2L2, BUB1, CDC25C, CDC23, PIK3R1, GNAI1, PIK3CG, CCNB2, ANAPC10, PRKACB, CDK1, CCNB3, CDC25A, CCNB1, MAPK8, CPEB1, IGF1, HSP90AB1, HSP90AA1, ANAPC13, PDE3A, PDE3B",0.402304814074488,0.146301788223826,FALSE +"transcriptomics","Log2FC","KEGG_PROPANOATE_METABOLISM",0.35657,1.04,0.37,3581,0.766,"LDHC, ACSS2, ALDH6A1, ABAT, MCEE, EHHADH, PCCB, ACSS1",0.431798275933005,0.115771230367396,FALSE +"transcriptomics","Log2FC","KEGG_PROSTATE_CANCER",0.26783,0.773,0.834,6422,1,"ERBB2, FGFR2, PDGFA, PIK3R2, IKBKB, MAPK3, PDGFB, PIK3CA, IGF1R, PDGFD, EP300, EGFR, E2F1, BRAF, CDKN1B, RELA, TCF7L1, CREB3L4, TGFA, FOXO1, BAD, PIK3R3, CCNE1, CREB3L3, CREB3L2, MAPK1, CREB5, CREB3L1, PIK3R5, PIK3CB, NFKBIA, PTEN, GSK3B, CDKN1A, CREB3",0.0788339493622613,0,FALSE +"transcriptomics","Log2FC","KEGG_PROTEASOME",-0.31612,-1.11,0.267,15132,0.637,"PSMB5, PSMD4, PSMD6, PSMC5, PSMB4, PSMA6, PSMD7, PSMC1, PSMC6, PSMD1, PSMC4, PSMB7, PSMA4, PSMA1, PSMD8, PSMB1, POMP, PSMD14",0.573488738635425,0.19586056766465,FALSE +"transcriptomics","Log2FC","KEGG_PROTEIN_EXPORT",-0.31244,-1.09,0.327,16054,0.584,"SEC61A2, SEC11A, SRPRB, SRP72, SRP9, SRP19, SEC11C, SEC63",0.485452247339714,0.233587152887601,FALSE +"transcriptomics","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.19349,0.564,0.994,8289,1,"GLS2, SLC9A3, SLC25A10, MDH1, SLC4A4, GLUD1, ATP1A2, AQP1, ATP1A1",0.00261361560268669,0,FALSE +"transcriptomics","Log2FC","KEGG_PURINE_METABOLISM",-0.30249,-1.01,0.33,15717,0.714,"PNPT1, PRPS1, RRM2, ADCY7, PFAS, POLR3B, ENTPD8, POLR2L, RRM2B, PAICS, ADSL, APRT, GART, NPR2, RRM1, PDE6B, PNP, PRIM1, NME1, PDE6C, POLR3G, PDE8A, POLR3A, AK5, NME7, PPAT, PDE11A, PRIM2, POLE3, POLR2E, POLR3C, PDE1A, ATIC, ENTPD1, PDE4B, PDE4D, POLR2D, POLR1E, PDE3A, PDE3B, POLA1, PDE10A, PDE7B, PDE8B",0.481486060122112,0.146301788223826,FALSE +"transcriptomics","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.25943,-0.931,0.538,14988,0.82,"DHODH, POLE, NT5E, NME2, UPP2, CAD, POLR2C, POLR3K, PNPT1, RRM2, POLR3B, ENTPD8, POLR2L, RRM2B, AK3, TXNRD1, DTYMK, RRM1, PNP, PRIM1, NME1, TYMS, POLR3G, POLR3A, NME7, PRIM2, POLE3, POLR2E, POLR3C, ENTPD1, POLR2D, POLR1E, UCK2, POLA1, CTPS1",0.269217724333611,0.0861861476162833,FALSE +"transcriptomics","Log2FC","KEGG_PYRUVATE_METABOLISM",0.22031,0.64,0.966,1378,0.993,"LDHC, ACSS2, PC",0.0150228735845067,0.00305075150461883,FALSE +"transcriptomics","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.28027,0.805,0.792,5612,1,"PAK6, SSH3, BDKRB2, MYH14, BAIAP2, FGF11, ITGB2, VAV1, FGFR2, ITGB6, PDGFA, PIK3R2, ITGB8, RAC2, VAV3, LIMK2, FGD3, ITGB4, ARHGEF4, MAPK3, PPP1CA, VAV2, GSN, PDGFB, PFN4, PIK3CA, PPP1CB, PIP4K2C, BDKRB1, FGF1, SSH2, PDGFD, ITGA3, EGFR, FGFR3, ITGA2B, BRAF, TIAM1, PXN, MYL9, TIAM2, ARHGAP35, PAK2, SLC9A1, ITGA2, WASL, FGF12, PIK3R3, PIP5K1C, LIMK1, CRKL, ARHGEF7, SCIN, MYL7, RAC1, IQGAP1, PAK1, RRAS, BCAR1, ITGAX, PAK4, MAPK1",0.101274818410506,0,FALSE +"transcriptomics","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.20206,-0.706,0.897,18035,1,"PIK3C3, PRKAA2, IFNA13",0.0472075569559079,0,FALSE +"transcriptomics","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.3643,1.05,0.363,5894,0.756,"GAB1, PAK6, PIK3R2, EGLN3, VEGFB, MAPK3, PDGFB, PIK3CA, MET, EP300, RAP1A, ARNT2, BRAF, TGFA, PAK2, PGF, EPAS1, VEGFA, PIK3R3, HIF1A, TGFB3, CRKL, FLCN, SLC2A1, VEGFC, RAC1, PAK1, PAK4, MAPK1, PIK3R5, PIK3CB",0.440093374963888,0.121478204498793,FALSE +"transcriptomics","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.39819,1.15,0.235,4025,0.711,"CTSA, ACE2, ACE, ANPEP",0.628932137728264,0.148130399270234,FALSE +"transcriptomics","Log2FC","KEGG_RETINOL_METABOLISM",0.43832,1.28,0.125,5807,0.772,"ADH7, RDH16, CYP26B1, DHRS9, DHRS3, DGAT1, CYP4A22, CYP26A1, UGT2B17, CYP1A1, RDH10, RDH11, LRAT, CYP26C1, CYP2C9, CYP2A7, ALDH1A2, AWAT2, CYP2C8",0.903089986991944,0.112382699664264,FALSE +"transcriptomics","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",0.28656,0.826,0.747,3165,1,"ACP6, ACP5, MTMR1",0.126679398184601,0,FALSE +"transcriptomics","Log2FC","KEGG_RIBOSOME",-0.37924,-1.29,0.169,14672,0.494,"RPL22L1, RPS23, RPL26, RPL21, RPL13A, RPS24, RPL10A, RPL37A, RPS11, RPS27A, RPL35, RPL10, RPL26L1, RPL34, RPL27A, RPLP0, RPL11, RPL32, RPS8, RPL18, RPS27, RPL9, RPS20, RPS10, RPS6, RPL4, RPL5, RPL14, RPSA, RPS13, RPS7, RPS19, RSL24D1, RPS12, RPL6, RPS4Y1, RPS16, RPL17",0.772113295386326,0.306273051076353,FALSE +"transcriptomics","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.42041,1.22,0.17,3761,0.712,"TRADD, TRAF6, DHX58, MAPK13, MAVS, IRF3, CXCL10, IKBKB, IFNB1, MAP3K1, TKFC, FADD, ISG15, IFIH1, DDX58, NLRX1, IL12B, CASP10, RELA, MAPK11, IKBKE",0.769551078621726,0.147520006363144,FALSE +"transcriptomics","Log2FC","KEGG_RNA_DEGRADATION",-0.39068,-1.41,0.0702,15014,0.339,"CNOT7, LSM2, EXOSC6, LSM1, LSM5, CNOT1, PNPT1, DCP1A, LSM7, EDC4, LSM3, EXOSC9, CNOT10, EXOSC5, EXOSC3, PAPOLA, TTC37, ZCCHC7, EXOSC10, MTREX, ENO1, DCP2, CNOT9, ENO3, EXOSC8, HSPA9, DCP1B, HSPD1",1.15366288787019,0.469800301796918,FALSE +"transcriptomics","Log2FC","KEGG_RNA_POLYMERASE",-0.36582,-1.22,0.208,17492,0.515,"POLR3G, POLR3A, POLR2E, POLR3C, POLR2D, POLR1E",0.681936665037238,0.288192770958809,FALSE +"transcriptomics","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",-0.20795,-0.735,0.909,17399,1,"SCLY, MAT2A, MARS2, SEPHS1, TRMT11",0.0414361167780325,0,FALSE +"transcriptomics","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.2741,0.794,0.807,4622,1,"LAMA3, TRAF6, RXRA, TRAF4, PIK3R2, LAMB3, LAMC2, IKBKB, PIK3CA, RXRB, MAX, ITGA3, E2F1, ITGA2B, CDKN1B, RELA, LAMA5, PIAS3, LAMB1, ITGA2, PIK3R3",0.0931264652779296,0,FALSE +"transcriptomics","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.44073,1.28,0.13,4358,0.772,"SNAP23, STX16, STX10, VAMP8, STX19, YKT6, STX17, VTI1B, TSNARE1, STX3, GOSR2, SNAP29, BET1, USE1, STX5, BET1L",0.886056647693163,0.112382699664264,FALSE +"transcriptomics","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",0.24714,0.704,0.913,8272,0.99,"ARSA, SPTLC2, NEU1, ASAH1, PLPP3, DEGS2, SPHK2, GLB1, SPHK1, GBA, SGMS2, SGPP1, SPTLC1, ENPP7, UGCG, SMPD3, SMPD2, SGPP2, NEU2, SMPD1, UGT8",0.039529222465701,0.00436480540245009,FALSE +"transcriptomics","Log2FC","KEGG_SPLICEOSOME",-0.28279,-0.977,0.457,14820,0.764,"HSPA1A, SNRNP27, DDX23, LSM2, SF3A3, SF3B1, SNRPB, SNRPF, PRPF8, BCAS2, LSM5, PRPF3, THOC1, SRSF3, SF3A2, DDX39B, EIF4A3, LSM7, SF3B4, TCERG1, RBM22, U2AF1, LSM3, SNRNP40, SYF2, DDX5, HNRNPK, DHX15, HNRNPA1L2, BUD31, PQBP1, PRPF40A, THOC2, PRPF4, SNRPA1, RBM8A, ALYREF, CDC5L, RBM17, SRSF7, SNRPE, PRPF18, SNRPD2, CDC40, SNRPC, RBMX, SRSF1, HNRNPA3, HSPA8, HNRNPM, HNRNPA1, HNRNPC, SF3B5, MAGOHB, PPIH, HNRNPU, PPIE, TXNL4A, SRSF10",0.34008379993015,0.11690664142431,FALSE +"transcriptomics","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.44369,1.28,0.138,7075,0.772,"HK2, GYS1, GCK, GAA, PGM1, GANC, UGT2B17, GUSB, HK1, UXS1, PYGL, PGM2, ENPP1, MGAM, PYGB, AMY1A, UGP2, AGL",0.860120913598763,0.112382699664264,FALSE +"transcriptomics","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.61834,1.78,0.00441,5003,0.457,"MSMO1, DHCR24, LIPA, SC5D, SQLE, FDFT1, HSD17B7, CEL, NSDHL, DHCR7, LSS, TM7SF2",2.35556141053216,0.34008379993015,FALSE +"transcriptomics","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38862,1.1,0.305,4669,0.737,"CYP11B1, CYP1B1, SULT2B1, SRD5A1, COMT, SRD5A3, CYP7B1, UGT2B17, HSD17B7, SULT1E1, CYP1A1, HSD17B8",0.515700160653214,0.132532512140949,FALSE +"transcriptomics","Log2FC","KEGG_SULFUR_METABOLISM",0.55174,1.58,0.02,5093,0.399,"SULT2B1, CHST12, SULT1A2, SUOX, SULT1A4, CHST11, SULT1E1, SULT1A3",1.69897000433602,0.399027104313252,FALSE +"transcriptomics","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.21402,-0.767,0.802,18576,1,"SSB, GRIN2B",0.0958256317158365,0,FALSE +"transcriptomics","Log2FC","KEGG_TASTE_TRANSDUCTION",0.22218,0.638,0.958,6205,0.988,"KCNB1, SCNN1A, ADCY4, TAS2R1, SCNN1G, TAS1R3, ADCY6, GNAS, TAS2R3, GRM4, TAS2R31, SCNN1B, ITPR3, PRKACA, TAS2R4, TAS2R38, TAS2R5",0.0186344909214556,0.00524305541237188,FALSE +"transcriptomics","Log2FC","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.24456,0.719,0.901,3450,1,"GGT7, GGT6",0.045275209020937,0,FALSE +"transcriptomics","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.41775,1.21,0.176,5412,0.727,"MVK, HMGCS1, MVD, DHDDS, HMGCR",0.75448733218585,0.138465589140962,FALSE +"transcriptomics","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.21463,-0.748,0.836,15652,1,"SMAD7, TFDP1, RHOA, BMPR2, SMAD5, PITX2, BMP8B, PPP2CB, PPP2R1B, ID3, SMAD4, SKP1, SMURF2, BMPR1A, INHBE, SMAD9, BMP8A, ID2, TGFB1, CDKN2B, E2F5, ROCK2, BMP6, SMAD2",0.0777937225609836,0,FALSE +"transcriptomics","Log2FC","KEGG_THYROID_CANCER",0.39121,1.14,0.227,3392,0.715,"CDH1, RXRA, MAPK3, RXRB, PPARG, BRAF, TCF7L1",0.643974142806877,0.145693958198919,FALSE +"transcriptomics","Log2FC","KEGG_TIGHT_JUNCTION",0.33254,0.958,0.527,4350,0.881,"EPB41L1, PRKCD, AMOTL1, MYH14, CLDN8, CGN, CLDN9, CLDN7, CLDN4, F11R, TJP3, CRB3, TJP2, PRKCH, LLGL2, CLDN18, PRKCI, PARD6B, PATJ, CLDN11, CTTN, EXOC4, CLDN23, CLDN3, SRC, MYH15, MYL9, EXOC3, MAGI1, PRKCZ, OCLN",0.278189384787453,0.0550240915879521,FALSE +"transcriptomics","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.43206,1.26,0.127,6260,0.73,"TLR5, TRAF6, MAPK13, PIK3R2, IRF5, LBP, IRF3, TOLLIP, CXCL10, IKBKB, MAPK3, TLR3, IFNB1, PIK3CA, MYD88, FADD, CXCL11, CCL5, CD40, IL12B, CXCL9, TAB1, RELA, TLR1, MAPK11, IKBKE, IL6, TLR2, MAP3K8, IRAK4, TIRAP, TICAM1, PIK3R3, STAT1, IL12A, RAC1, TAB2, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB, NFKBIA, FOS, IRF7",0.896196279044043,0.136677139879544,FALSE +"transcriptomics","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",0.25994,0.758,0.85,5698,0.999,"CAT, CYP1B1, GCDH, KMO, EHHADH, IL4I1, CYP1A1, MAOA, IDO1, HAAO, OGDHL",0.0705810742857073,0.000434511774017692,FALSE +"transcriptomics","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",0.35999,1.05,0.353,1965,0.756,"PRKCD, HK2, PIK3R2, CACNA1D, SOCS1, GCK, IKBKB, MAPK3, INSR, PIK3CA",0.452225294612177,0.121478204498793,FALSE +"transcriptomics","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",-0.22684,-0.798,0.842,16990,1,"PRF1, PTPRN, HSPD1",0.0746879085003505,0,FALSE +"transcriptomics","Log2FC","KEGG_TYROSINE_METABOLISM",0.48583,1.4,0.0669,2773,0.658,"ADH7, ALDH3B2, HEMK1, TH, ALDH1A3, ALDH3B1, COMT, AOC2, GSTZ1, NAA80, LCMT1",1.17457388223218,0.181774106386044,FALSE +"transcriptomics","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.29483,0.849,0.722,6624,0.989,"PAK6, CBLC, VAV1, MAPK13, PIK3R2, VAV3, DLG1, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, NCK2, CBLB, PLCG1, RELA, CHP1, MAPK11, PPP3CA, PAK2, LCK, MAP3K8, CSF2, PIK3R3, CD4, NCK1, PAK1, PAK4, MAPK1, MAP2K7, NFATC1, PIK3R5, PIK3CB, NFKBIA, GSK3B, FOS, NFATC4, GRB2, CHP2",0.141462802430361,0.0048037084028206,FALSE +"transcriptomics","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29203,0.86,0.693,6099,0.973,"CBLC, UBOX5, ITCH, UBA7, TRAF6, UBE2H, PPIL2, SOCS1, FBXO2, SMURF1, PML, MAP3K1, FBXW7, UBE2L6, RHOBTB2, HERC1, HERC3, ANAPC2, CUL7, UBE2D4, CBLB, FBXO4, RNF7, MID1, SYVN1, UBA6, FBXW8, UBR5, UBE2C, PIAS3, KLHL13, UBE3B, UBE2W, HUWE1, NEDD4L, UBE2F, TRIM32, UBE2Q1, WWP2, DDB1, SIAH1, FZR1, UBE4A, UBE2E1, UBE3C, DET1, UBE2O, UBE2E2, STUB1, UBA3, ANAPC11, UBE2M, UBE2Z",0.159266765388193,0.0118871597316481,FALSE +"transcriptomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.54815,-1.88,0.02,13596,0.161,"VARS2, LARS2, BCAT1, PDHA1, IARS2",1.69897000433602,0.79317412396815,TRUE +"transcriptomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.42231,1.22,0.182,3822,0.712,"MCCC1, ACAA1, HIBADH, ACAD8, ALDH6A1, ABAT, HMGCL, HMGCS1, MCEE, ACADS, EHHADH, PCCB, IL4I1, AUH",0.739928612014925,0.147520006363144,FALSE +"transcriptomics","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.28813,0.847,0.739,4348,0.985,"PRKCD, PLA2G12A, KCNMB3, CACNA1D, PLA2G6, CALML3, PLA2G4B, ADORA2B, MAPK3, ADORA2A, PPP1CA, PRKCH, ADCY5, CYP4A22, PPP1CB, ADCY4, PLA2G10, PLA2G4E, BRAF, ADCY6, MYL9, PLA2G2C, EDNRA, KCNMB4, GNAS, GNAQ",0.131355561605174,0.00656376950238827,FALSE +"transcriptomics","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.27394,0.798,0.785,7785,1,"DYNLL2, AQP3, RAB5B, ARHGDIB, ADCY6, CREB3L4, GNAS, DYNC2LI1, DCTN5, CREB3L3, PRKACA, CREB3L2, RAB11B, RAB5C, CREB5, CREB3L1, CREB3, ADCY9, ADCY3, NSF, CREB1, RAB11A, PRKACG, DCTN1",0.105130343254747,0,FALSE +"transcriptomics","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.37587,1.09,0.307,5894,0.756,"PLA2G12A, MAPK13, PIK3R2, PLCG2, RAC2, PLA2G6, PLA2G4B, NOS3, HSPB1, MAPK3, PIK3CA, PLA2G10, PLA2G4E, MAPKAPK3, PLCG1, SPHK2, PXN, SRC, CHP1, MAPK11, PPP3CA, PLA2G2C, BAD, VEGFA, PIK3R3, SPHK1, MAPKAPK2, RAC1, MAPK1, NFATC1, PIK3R5, PIK3CB",0.512861624522813,0.121478204498793,FALSE +"transcriptomics","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",0.35881,1.05,0.364,7679,0.756,"ERO1A, PLCG2, ATP6V1C2, TJP2, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP6AP1, KDELR3, PLCG1, PDIA4, GNAS, TCIRG1, KCNQ1, ATP6V1G1, SEC61G, ATP6V0A4, PRKACA, KDELR2, ATP6V1C1, TJP1, ATP6V1E1, ADCY9, ADCY3, SEC61B, ATP6V0C, PRKACG, ATP6V1E2, ATP6V0E2",0.438898616350944,0.121478204498793,FALSE +"transcriptomics","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.26233,0.751,0.855,3633,0.986,"MYH14, ITGB2, RAC2, DAG1, CD40, EIF4G1, CAV1, MYH15",0.0680338852718274,0.0061230850587888,FALSE +"transcriptomics","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.25146,0.726,0.884,2541,1,"WNT3A, WNT9A, TBL1XR1, WNT7B, DAAM1, FZD10, PORCN, WNT7A, RAC2, SENP2, WNT4, FRAT1, CTNNBIP1, DVL3, CAMK2G, FRAT2, CSNK1E, WNT10A, LRP5, CSNK1A1, EP300, VANGL2",0.0535477349869269,0,FALSE +"proteomics","Log2FC","KEGG_ABC_TRANSPORTERS",-0.56716,-1.68,0.037,8609,0.508,"ABCC5, ABCA1, ABCG1, ABCA10, ABCB1, ABCC10, ABCB7, ABCB5, ABCC1, ABCC4, ABCC6, ABCB4, ABCB10, ABCA7, ABCA3, ABCA13, ABCC2, ABCB11",1.431798275933,0.294136287716081,FALSE +"proteomics","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.42626,1.21,0.208,2845,0.611,"PIK3CD, RARA, RUNX1, LEF1, CCND1, KRAS, NRAS, FLT3, PIK3R2, PIK3CA, STAT3, IKBKB, HRAS, EIF4EBP1, MAPK3, GRB2, RPS6KB2, SOS2, TCF7L1, MAPK1",0.681936665037238,0.213958789757446,FALSE +"proteomics","Log2FC","KEGG_ADHERENS_JUNCTION",0.47199,1.35,0.113,1296,0.576,"RAC2, NECTIN4, CDH1, SNAI2, CTNND1, ACTN3, CTNNA1, NECTIN1, CTNNA2, CTNNB1, BAIAP2, ERBB2, RAC3, EP300, LMO7, PTPN6, PTPRF, EGFR, LEF1",0.94692155651658,0.239577516576788,FALSE +"proteomics","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.31768,0.883,0.577,2689,0.999,"CD36, RXRA, RXRG, IRS1, ACSL4, ACSL1, PRKCQ, ACSL6, SLC2A1, ACSL5, STAT3, IKBKB, NFKBIA, PRKAB2, ACSL3",0.238824186844269,0.000434511774017692,FALSE +"proteomics","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.24638,0.697,0.875,2010,1,"GLUL, ABAT, GLUD2, GFPT1, GPT2",0.0579919469776868,0,FALSE +"proteomics","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.56793,1.6,0.0445,3523,0.561,"SCNN1A, ATP1A2, PIK3CD, IRS1, PDPK1, KRAS, HSD11B2, PIK3R2, PIK3CA, MAPK3, SCNN1B, MAPK1, SFN, ATP1A3, ATP1A4, ATP1A1, PRKCG",1.35163998901907,0.251037138743839,FALSE +"proteomics","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.58978,1.63,0.0413,2132,0.638,"FADS2, PLA2G12A, PLA2G2A, ACOX1, ACOX3",1.3840499483436,0.195179321278838,FALSE +"proteomics","Log2FC","KEGG_ALZHEIMERS_DISEASE",-0.26665,-0.782,0.738,8102,0.881,"PSEN1, NDUFV1, UQCRC1, COX7A2, NDUFA6, ERN1, NDUFC1, BAD, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, NDUFA2, NDUFS3, ATP5F1D, MAPT, ATP5PF, NDUFB4, HSD17B10, NDUFA3, ITPR2, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, IDE, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, ATP5F1C, PPP3CC, ITPR1, PLCB2, ATP5F1B, ATP5PB, ATP5PD, NDUFB2, ATP5MC2, BACE2, CASP7, PLCB4, PSEN2",0.131943638176958,0.0550240915879521,FALSE +"proteomics","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.38256,-1.16,0.237,7208,0.551,"AARS2, FARSB, FARS2, SARS2, LARS2, DARS2, YARS2, MTFMT, EARS2, WARS2, RARS2",0.625251653989896,0.258848401148215,FALSE +"proteomics","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.27352,0.756,0.778,2412,1,"HK1, MPI, NPL, RENBP, PGM1, NAGK, GMPPA, GFPT1, HK2, GALT, PGM2, GALE",0.109020403010311,0,FALSE +"proteomics","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.34389,-0.985,0.441,10318,0.668,"NEFM, MAP2K6, MAPK11, SOD1, NEFL, PRPH, PRPH2, NEFH",0.355561410532161,0.175223537524454,FALSE +"proteomics","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.32022,0.881,0.594,3597,0.989,"CTSS, IFI30, CD74, CALR, LGMN, HSPA6, TAPBP, HSPA1A, PSME2, CREB1, PSME1, CTSB",0.226213555018806,0.0048037084028206,FALSE +"proteomics","Log2FC","KEGG_APOPTOSIS",0.23693,0.666,0.911,2534,1,"IL1R1, BCL2, IL1RAP, ENDOD1, PIK3CD, CASP10, MYD88, PPP3R1, PPP3CA, PPP3CB, PPP3R2, PIK3R2, TP53, CASP6, PIK3CA, IKBKB, PRKAR1B, CAPN2, NFKBIA, ENDOG",0.0404816230270017,0,FALSE +"proteomics","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",0.4694,1.33,0.125,2120,0.597,"GGT5, PTGS2, PLA2G12A, EPHX2, ALOX5, GPX6, GPX7, PTGES, PLA2G2A, GPX1, GGT7, GPX3",0.903089986991944,0.224025668870631,FALSE +"proteomics","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34932,0.983,0.453,2841,0.905,"GLUL, OAT, PRODH, PRODH2, GATM, ARG1, NOS3, CKMT1A, CKMT2, GLUD2, NOS1, P4HA2, NAGS, ARG2, P4HA1, PYCR3, MAOA, ASL, OTC, ALDH18A1",0.343901797987168,0.0433514207947967,FALSE +"proteomics","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.33473,0.926,0.513,1866,0.961,"ITGB6, ITGB8, ACTN3, CTNNA1, ITGB4, CTNNA2, CTNNB1, DSC2, ITGA2, ITGA11, SGCG, LEF1, ITGA4, CACNA1F, GJA1, ITGA3, PKP2",0.289882634888184,0.0172766123314547,FALSE +"proteomics","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.61182,-1.82,0.0194,7847,0.331,"ALDH9A1, ALDH1B1, ALDH3A2, ALDH2, ALDH7A1",1.71219827006977,0.480172006224281,FALSE +"proteomics","Log2FC","KEGG_AXON_GUIDANCE",0.46405,1.3,0.155,2598,0.539,"RAC2, PAK5, PAK6, NGEF, EPHA1, EPHB2, RGS3, ROBO2, NTN4, SEMA4B, NFATC4, EFNB2, EFNA1, SEMA7A, RAC3, PLXNB2, PPP3R1, SEMA3A, SEMA3C, PPP3CA, PPP3CB, PLXNA2, EPHB4, PPP3R2, EPHA4, SEMA4D, KRAS, NRAS, SLIT2, EPHB3, EPHB1, RHOA, NFATC1, SLIT1, SLIT3, RAC1, MET, LIMK2, HRAS, MAPK3, PLXNA1, ABLIM1, NFATC3, NTN1, NFATC2, RHOD",0.809668301829709,0.268411234813261,FALSE +"proteomics","Log2FC","KEGG_BASAL_CELL_CARCINOMA",-0.25512,-0.759,0.782,10364,0.882,"WNT10A, GLI2, GLI3",0.106793246940152,0.0545314148681803,FALSE +"proteomics","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.41284,-1.19,0.222,7232,0.554,"GTF2A1, STON1, GTF2E2, TAF10, TBP, GTF2H3, GTF2A2, GTF2F2, GTF2H4, GTF2H1, TAF12, GTF2H2, GTF2F1, TAF13, TBPL1",0.653647025549361,0.25649023527157,FALSE +"proteomics","Log2FC","KEGG_BASE_EXCISION_REPAIR",-0.24796,-0.732,0.82,9965,0.902,"POLL, NTHL1, MUTYH",0.0861861476162833,0.0447934624580583,FALSE +"proteomics","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.28968,-0.838,0.61,7434,0.796,"SRM, ECHS1, MLYCD, ALDH9A1, EHHADH, ALDH1B1, ALDH3A2, ALDH2, ALDH7A1",0.214670164989233,0.0990869322623309,FALSE +"proteomics","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.35293,-1.03,0.356,9642,0.653,"HACD1, YOD1, PECR, ACOT7, ELOVL2",0.448550002027125,0.185086818724926,FALSE +"proteomics","Log2FC","KEGG_BLADDER_CANCER",0.463,1.32,0.129,2596,0.575,"CDH1, VEGFA, THBS1, ERBB2, VEGFC, EGFR, CDK4, CCND1, KRAS, NRAS, CDKN1A, MMP2, TP53, HRAS, MAPK3, CDKN2A",0.889410289700751,0.24033215531037,FALSE +"proteomics","Log2FC","KEGG_BUTANOATE_METABOLISM",0.29975,0.837,0.633,891,1,"ABAT, HMGCS1, ACSM3, BDH2",0.198596289982645,0,FALSE +"proteomics","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.52452,1.49,0.0618,2561,0.572,"RAC2, DAPP1, CARD11, NFATC4, PIK3CD, RAC3, LYN, CD79A, PTPN6, PIK3AP1, PPP3R1, VAV1, PPP3CA, VAV2, PPP3CB, PPP3R2, KRAS, NRAS, CD81, NFATC1, PIK3R2, RAC1, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, VAV3, GRB2, NFATC3, NFATC2, SOS2",1.20901152491118,0.242603971206976,FALSE +"proteomics","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.24843,0.683,0.875,1708,1,"TNNC1, ERBB3, GNA15, TNNC2, NOS3, ERBB2, ERBB4, ATP2A3, PPP3R1, EGFR, PPP3CA, PPP3CB, PPP3R2, NOS1, PTK2B, CACNA1F, CACNA1A",0.0579919469776868,0,FALSE +"proteomics","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.35378,0.994,0.413,840,0.892,"TNNC1, MYH7, ATP1A2, SLC9A1",0.384049948343599,0.0496351456238769,FALSE +"proteomics","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.48094,1.36,0.133,793,0.604,"CLDN18, CLDN4, CLDN7, CDH15, CDH3, CDH5, SDC4, ITGAL, SDC1, ITGB8, ITGB2, CLDN3, CDH1, F11R, CLDN6, VCAN, JAM2, SDC2, NECTIN1, SDC3, CD274, ICAM2",0.876148359032914,0.218963061378868,FALSE +"proteomics","Log2FC","KEGG_CELL_CYCLE",0.18042,0.514,0.989,2700,1,"FZR1, CDC6, WEE1, EP300, CDC7, CHEK2, ANAPC11, CDKN1C, CDK4, SKP2, CCND1, CCNB1, BUB1, CDKN1A, CCNA2, RBL1, CREBBP, TP53, PCNA, CHEK1, BUB1B, CDKN2A, HDAC1, ZBTB17",0.0048037084028206,0,FALSE +"proteomics","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.28479,-0.842,0.649,10271,0.801,"PLCB4, CXCL10, DOCK2, ADCY6, GNG7, SHC4, CCR10, CCR9, WAS, CXCL5, RASGRP2, CXCL14",0.187755303199631,0.0963674839157623,FALSE +"proteomics","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.23803,0.664,0.913,2652,0.993,"PIK3CD, MECOM, RUNX1, CDK4, CCND1, KRAS, NRAS, CDKN1A, BCR, PIK3R2, TP53, PIK3CA, CTBP1, IKBKB, HRAS, MAPK3, NFKBIA, CBLB, GRB2, SOS2, CDKN2A, HDAC1",0.039529222465701,0.00305075150461883,FALSE +"proteomics","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.51999,1.46,0.0752,2428,0.601,"BHLHE41, PER2, NR1D1, CSNK1E, ARNTL",1.12378215940836,0.22112552799726,FALSE +"proteomics","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.18745,-0.56,0.99,2896,0.996,"IDH1, SUCLG2, ACO1, DLD, ACLY, ACO2, DLST, PCK1, MDH2, MDH1, SDHA, SUCLG1, OGDHL, DLAT, OGDH, PC, SUCLA2, IDH3B, SDHB, CS, SDHC, IDH3A, PDHB, PDHA1, IDH3G, FH, SDHD, PCK2",0.00436480540245009,0.00174066157630127,FALSE +"proteomics","Log2FC","KEGG_COLORECTAL_CANCER",0.32298,0.911,0.552,2210,0.955,"RAC2, BCL2, CTNNB1, PIK3CD, RAC3, LEF1, CCND1, KRAS, RHOA, PIK3R2, TP53, RAC1, PIK3CA",0.258060922270801,0.0199966284162537,FALSE +"proteomics","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.403,1.11,0.287,944,0.696,"CFI, CFB, SERPINA1, TFPI, FGG, FGB, SERPINA5, MASP1, PLAT, PLAU, SERPINC1, F3",0.542118103266008,0.157390760389438,FALSE +"proteomics","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.39207,-1.14,0.241,8054,0.566,"APIP, GOT1, MAT2B, SDS, GOT2, CBS, MAT2A, MAT1A, MTAP, AMD1, CDO1",0.617982957425132,0.247183568811729,FALSE +"proteomics","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.46198,-1.39,0.103,10106,0.603,"TNFRSF10A, TGFB1, BMPR2, CXCL10, INHBA, TNFRSF19, ACVR2A, CD70, TNFSF9, TGFB2, CD40, BMPR1A, TNFRSF10C, CCR10, CCR9, IL1A, IFNAR2, CXCL5, INHBE, CXCL14, PDGFRA",0.987162775294828,0.219682687859849,FALSE +"proteomics","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.16559,0.464,1,2883,1,"CASP1, RIPK3, DDX58, IL18, IKBKB, NFKBIA, IKBKE, IL1B",0,0,FALSE +"proteomics","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",-0.30863,-0.912,0.509,10453,0.713,"ADCY6, TGFB2, TPM2, LAMA2, CACNA2D2, SGCD, CACNA2D1, ITGA10, DES",0.293282217663241,0.146910470148134,FALSE +"proteomics","Log2FC","KEGG_DNA_REPLICATION",-0.20491,-0.61,0.962,2252,1,"PCNA, LIG1, RFC5, POLD4, RFC2, RFC3, POLE, RFC1, RPA3, POLE4, POLD3, RFC4, MCM4, POLE3, MCM6, POLD1, MCM5, MCM7, RPA2, SSBP1, RNASEH2A, MCM3, POLE2, POLD2, FEN1, PRIM1, RPA1, MCM2, DNA2, RNASEH1, PRIM2, POLA1, POLA2, RNASEH2C, RNASEH2B",0.0168249279621871,0,FALSE +"proteomics","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.55702,1.57,0.045,2561,0.481,"ETS2, ETV6, EGFR, NOTCH3, KRAS, PIWIL2, MAPK3, GRB2, SOS2",1.34678748622466,0.317854923626168,FALSE +"proteomics","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.35951,1.01,0.423,1430,0.867,"FMO5, GSTA5, ADH4, ADH7, FMO2, FMO4, MGST2, ALDH1A3, MGST1, ALDH3B1, FMO3",0.373659632624958,0.0619809025237897,FALSE +"proteomics","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.42011,-1.23,0.195,9395,0.525,"GMPS, CYP3A5, UCK2, UMPS, NAT2, CYP3A7",0.709965388637482,0.279840696594043,FALSE +"proteomics","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.43662,1.24,0.197,1082,0.577,"ITGB6, TNC, SDC4, CD36, SDC1, ITGB8, ITGB4, SDC2, LAMC2, LAMB3, THBS1, SDC3, CD47, ITGA2, ITGA11, LAMA3, LAMA4",0.705533773838407,0.238824186844269,FALSE +"proteomics","Log2FC","KEGG_ENDOCYTOSIS",0.2991,0.833,0.674,2726,0.992,"EPN3, PSD4, ERBB3, ARRB1, CHMP2B, ASAP3, RAB11FIP1, RAB11FIP4, ERBB4, DNAJC6, ARAP3, EGFR, GRK2, AGAP1, TRAF6, PRKCZ, AGAP2, RAB22A, EHD2, PRKCI, PARD6G, ITCH, ARF6, RAB11B, RAB31, RAB11A, CHMP4C, MET, LDLRAP1, CHMP4A, CHMP4B, CHMP2A, CLTCL1, PARD6B, HRAS, EPS15, CBLB, IGF1R, HSPA6, VPS37B, RAB5B, PARD6A, EPN1",0.17134010346468,0.00348832784582135,FALSE +"proteomics","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.50929,1.41,0.102,2624,0.606,"CDH1, CTNNA1, CTNNA2, CTNNB1, ERBB2, PIK3CD, EGFR, LEF1, PDPK1, CCND1, KRAS, NRAS, PIK3R2, TP53, PIK3CA, HRAS, MAPK3, GRB2, SOS2, TCF7L1",0.991399828238082,0.217527375833714,FALSE +"proteomics","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.31162,0.868,0.587,1141,0.992,"CXCL1, F11R, JAM2, MAPK12, MAPK13, LYN, EGFR",0.231361898752386,0.00348832784582135,FALSE +"proteomics","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.41192,1.15,0.276,2561,0.697,"EREG, ERBB3, AREG, PAK5, PAK6, TGFA, ERBB2, PIK3CD, ERBB4, EGFR, GAB1, KRAS, NRAS, CDKN1A, PIK3R2, PIK3CA, HRAS, EIF4EBP1, MAPK3, CAMK2D, ABL2, CBLB, GRB2, RPS6KB2, SOS2",0.559090917934782,0.156767221901991,FALSE +"proteomics","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.4815,1.36,0.137,2108,0.604,"LPCAT2, PLA2G12A, PAFAH2, PLA2G2A, LPCAT4, LPCAT1, PLPP3",0.863279432843593,0.218963061378868,FALSE +"proteomics","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.299,0.835,0.678,2361,1,"ADH4, ADH7, ACSL4, ACAA1, ACSL1, ACOX1, CPT2, ACSL6, ADH1C, ACOX3, ACADM, ACSL5, ACADS",0.168770306132937,0,FALSE +"proteomics","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.46449,1.31,0.129,2664,0.537,"RAC2, PRKCD, MAPK12, PIK3CD, MAPK13, PLA2G12A, RAC3, LYN, VAV1, LCP2, VAV2, PLA2G2A, PDPK1, KRAS, NRAS, PIK3R2, RAC1, PIK3CA, HRAS, MAPK3, VAV3, GRB2, SOS2, MAPK14",0.889410289700751,0.270025714300444,FALSE +"proteomics","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.3637,1.01,0.405,2557,0.867,"RAC2, PRKCD, AMPH, ASAP3, SCIN, PIK3CD, LYN, VAV1, GSN, MYO10, HCK, VAV2, MARCKS, MARCKSL1, PLA2G4F, ARF6, PTPRC, PIK3R2, PLPP3, RAC1, PIK3CA, LIMK2, MAPK3, VAV3, RPS6KB2",0.392544976785331,0.0619809025237897,FALSE +"proteomics","Log2FC","KEGG_FOCAL_ADHESION",0.29325,0.832,0.673,1355,0.981,"ITGB6, TNC, RAC2, BCL2, PAK5, PAK6, ITGB8, VEGFA, ACTN3, ITGB4, LAMC2, LAMB3, THBS1, CTNNB1, ERBB2, VEGFC, PIK3CD, RAC3, VAV1, ITGA2, ITGA11, LAMA3, LAMA4, EGFR, VAV2, PDPK1, CCND1",0.171984935776023,0.0083309926200515,FALSE +"proteomics","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.38519,1.09,0.318,2050,0.711,"ALPI, ALPP, ALPG, FPGS, PTS",0.497572880015567,0.148130399270234,FALSE +"proteomics","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.59056,1.66,0.0345,2113,0.786,"ALDOB, FBP1, ALDOC, PFKFB4, MTMR7, HK1, FBP2, PFKFB2, MPI, GMPPA, MTMR1, HK2",1.46218090492673,0.104577453960592,FALSE +"proteomics","Log2FC","KEGG_GALACTOSE_METABOLISM",0.35287,0.981,0.462,2908,0.894,"B4GALT1, HK1, PGM1, HK2, GAA, GALT, PGM2, GALE, UGP2, MGAM",0.335358024443874,0.0486624812040823,FALSE +"proteomics","Log2FC","KEGG_GAP_JUNCTION",-0.39068,-1.13,0.254,9590,0.567,"GNAI1, ITPR1, PLCB2, TUBA8, TUBA3C, TUBB6, GRM5, PLCB4, MAP2K5, ADCY6, TUBB2B, PDGFRA",0.595166283380062,0.246416941107093,FALSE +"proteomics","Log2FC","KEGG_GLIOMA",-0.32991,-0.973,0.446,10540,0.676,"CDK6, SHC4, PDGFRA",0.350665141287858,0.170053304058364,FALSE +"proteomics","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.28325,0.797,0.743,2603,0.996,"GGT5, GSTA5, MGST2, GPX6, GPX7, MGST1, GSTK1, GPX1, IDH2, GGT7, GPX3, MGST3, G6PD, ANPEP, GSTT2",0.129011186239425,0.00174066157630127,FALSE +"proteomics","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.32775,0.925,0.512,2176,0.948,"LIPC, LPL, MGLL, LIPG, DGKA, DGKH, MBOAT2, DGKB, PLPP3, DGAT1",0.290730039024169,0.0231916626619338,FALSE +"proteomics","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.34171,0.956,0.482,3460,0.928,"PEMT, DGKA, LPCAT2, PLA2G12A, CDS1, DGKH, PLA2G2A, CHKA, LPCAT4, MBOAT2, LPCAT1, DGKB, LYPLA2, PLPP3, PISD, PCYT2, LPGAT1, GPD1L, MBOAT1, DGKZ, PLA2G4A, GPD2, CHKB, LPCAT3, DGKQ",0.31695296176115,0.0324520237811379,FALSE +"proteomics","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.30658,-0.896,0.565,9064,0.732,"CBS, AGXT, ALAS1, PHGDH, PIPOX, PSAT1, MAOB, GLDC",0.247951552180562,0.135488918941608,FALSE +"proteomics","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.45991,1.31,0.131,881,0.537,"ALDOB, PGAM2, FBP1, ALDOC, ADH4, ADH7, GALM, HK1, FBP2, ACSS2, ALDH1A3",0.882728704344236,0.270025714300444,FALSE +"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.34596,-1.02,0.372,9904,0.627,"XYLT1, CSGALNACT2, CHST3, CHST7",0.429457060118102,0.202732459169284,FALSE +"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.34182,0.971,0.442,3070,0.904,"HS6ST2, HS6ST1, XYLT2, EXT2, EXT1, EXTL3",0.354577730650908,0.0438315695246367,FALSE +"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66613,1.85,0.0113,2887,0.765,"B4GALT1, FUT8, B4GALT3, ST3GAL1, B3GNT2, B4GALT4",1.94692155651658,0.116338564846382,FALSE +"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.43357,-1.27,0.195,9910,0.57,"HEXA, IDUA, ARSB, HYAL1",0.709965388637482,0.244125144327509,FALSE +"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.51004,-1.47,0.0904,7952,0.584,"HEXB, ST3GAL5, HEXA, B4GALNT1",1.04383156952464,0.233587152887601,FALSE +"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.56837,1.59,0.053,725,0.481,"B3GALNT1, B3GALT5",1.27572413039921,0.317854923626168,FALSE +"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.62329,1.76,0.011,2178,0.817,"B3GNT3, FUT3, B4GALT1, B3GALT5, B4GALT3, ST3GAL4, B3GNT2",1.95860731484178,0.0877779434675845,FALSE +"proteomics","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.25881,-0.767,0.752,8687,0.882,"PIGN, PIGQ, PIGB, PIGM, PIGX",0.123782159408358,0.0545314148681803,FALSE +"proteomics","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.16598,0.474,0.998,4328,1,"AFMID, GLYCTK, ACO1, ACO2, MDH2, MTHFD2L, MDH1, MTHFD1",0.000869458712628891,0,FALSE +"proteomics","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.23616,0.653,0.91,3427,0.995,"PRKCD, MAPK12, MAPK13, PLA2G12A, CGA, EGFR, PLA2G2A, KRAS, NRAS, PTK2B, CACNA1F, MAP3K1, MMP2, PLCB1, HRAS, MAPK3, CAMK2D, GRB2, SOS2, MAPK14, MAPK1, PLA2G4A, MMP14, GNA11, ADCY9, CDC42, CAMK2B, PLCB3, SOS1, ADCY5",0.0409586076789064,0.00217691925427455,FALSE +"proteomics","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.30481,-0.883,0.56,10364,0.745,"WNT10A, GLI2, GLI3",0.2518119729938,0.127843727251707,FALSE +"proteomics","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.29233,0.814,0.68,1843,0.984,"IL1R1, CD36, CD9, ITGA2, ITGA4, ITGA3, FLT3, CD33",0.167491087293764,0.00700490156865849,FALSE +"proteomics","Log2FC","KEGG_HISTIDINE_METABOLISM",-0.34944,-1.02,0.398,10443,0.627,"ALDH2, MAOB, ALDH7A1, ALDH3A1",0.400116927926312,0.202732459169284,FALSE +"proteomics","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",-0.38362,-1.12,0.295,9496,0.536,"RAD50, MUS81, MRE11, RAD52",0.530177984021837,0.27083521030723,FALSE +"proteomics","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.35692,-1.02,0.375,7298,0.627,"NDUFV2, COX7C, POLR2L, NDUFS4, SDHB, NDUFB5, POLR2I, COX4I1, POLR2A, SDHC, COX6B1, DCTN4, COX6A1, POLR2E, CYCS, DCTN2, DNAL1, TBP, NDUFV1, UQCRC1, COX7A2, NDUFA6, NDUFC1, POLR2H, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, SLC25A6, BAX, NDUFA2, DCTN1, TFAM, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, VDAC1, NDUFA3, HIP1, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, DNAH3, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, TGM2, ATP5F1C, SOD2, AP2A2, ITPR1, PLCB2, ATP5F1B, ATP5PB, SLC25A4, ATP5PD, NDUFB2, ATP5MC2, TBPL1, GRM5, PLCB4, BBC3, SOD1",0.425968732272281,0.202732459169284,FALSE +"proteomics","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.32547,-0.949,0.454,10552,0.68,"TGFB2, PRKAA2, TPM2, LAMA2, CACNA2D2, SGCD, CACNA2D1, ITGA10, DES",0.342944147142896,0.167491087293764,FALSE +"proteomics","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.25705,0.73,0.81,3346,1,"IMPA2, INPP4B, PIK3CD, PIP4K2C, ALDH6A1, PLCB1, PIK3C2B, PIK3CA, PI4KA, PLCD1, ISYNA1, INPP5B, INPP5A, PIP4K2A, PI4KB, SYNJ2, PLCB3",0.0915149811213502,0,FALSE +"proteomics","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.20113,0.569,0.984,2750,1,"FBP1, PIK3CD, HK1, FBP2, PTPRF, IRS1, PDPK1, KRAS, NRAS, PRKCZ, PYGB, PRKCI, EXOC7, MKNK1, PIK3R2, HK2, PIK3CA, PTPN1, PPP1R3D, IKBKB, PRKAR1B, HRAS, EIF4EBP1, MAPK3, RHEB, CBLB, GRB2, RPS6KB2, SOS2, PRKAB2, PYGL, GYS1",0.00700490156865849,0,FALSE +"proteomics","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.50265,-1.47,0.0964,10060,0.584,"ICOSLG, TGFB1, CD40, CCR10, CCR9",1.01592296609717,0.233587152887601,FALSE +"proteomics","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.27492,0.772,0.76,2561,1,"SPRY2, LIFR, PIK3CD, EP300, PTPN6, STAT2, IL13RA1, IFNGR1, CCND1, IRF9, STAT1, OSMR, STAT6, SPRY1, CREBBP, PIK3R2, JAK1, PIAS3, PIK3CA, STAT3, CBLB, GRB2, SOS2",0.119186407719209,0,FALSE +"proteomics","Log2FC","KEGG_LEISHMANIA_INFECTION",0.37967,1.06,0.336,2883,0.769,"ITGB2, PTGS2, MAPK12, MAPK13, MYD88, PTPN6, IFNGR1, STAT1, ITGA4, TRAF6, MARCKSL1, JAK1, MAPK3, NFKBIA, MAPK14, C3, MAPK1, IL1B",0.473660722610156,0.114073660198569,FALSE +"proteomics","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.50535,1.41,0.105,809,0.606,"CLDN18, CLDN4, CLDN7, RAC2, CDH5, ITGAL, ITGB2, CLDN3, F11R, CLDN6, CTNND1, ACTN3, CTNNA1, JAM2, MAPK12, CTNNA2, CTNNB1, PIK3CD, MAPK13",0.978810700930062,0.217527375833714,FALSE +"proteomics","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.6513,-1.88,0.0167,7847,0.425,"ALDH9A1, EHHADH, ALDH1B1, ALDH3A2, YOD1, ALDH2, ALDH7A1, NAA80",1.77728352885242,0.371611069949688,FALSE +"proteomics","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",-0.568,-1.63,0.0607,10332,0.523,"PLA2G6, CYP3A7",1.21681130892474,0.281498311132726,FALSE +"proteomics","Log2FC","KEGG_LONG_TERM_DEPRESSION",-0.22631,-0.661,0.91,9590,0.995,"GNAI1, ITPR1, PLCB2, GRM5, PLCB4, PLA2G6, PPP1R17",0.0409586076789064,0.00217691925427455,FALSE +"proteomics","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.24302,0.679,0.884,2407,0.994,"EP300, PPP3R1, PPP3CA, PPP3CB, PPP3R2, KRAS, NRAS, RPS6KA1, CREBBP, RPS6KA6, PLCB1, RPS6KA2, HRAS, MAPK3, CAMK2D",0.0535477349869269,0.00261361560268669,FALSE +"proteomics","Log2FC","KEGG_LYSINE_DEGRADATION",-0.35898,-1.07,0.315,10138,0.61,"TMLHE, PIPOX, ALDH2, ALDH7A1, AADAT, BBOX1",0.501689446210399,0.214670164989233,FALSE +"proteomics","Log2FC","KEGG_LYSOSOME",0.25134,0.696,0.878,1651,1,"CTSE, CTSH, AP1M2, CTSS, ACP5, LAMP3, NEU1, NPC2, NAPSA, CTSA, SLC11A2, GM2A, AP1B1, AP1S1, FUCA1, SGSH",0.0565054840938974,0,FALSE +"proteomics","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",-0.30167,-0.882,0.566,9929,0.733,"TGFB3, DUSP16, MAPK8, FLNC, DDIT3, MKNK2, FGFR1, TGFB1, MAP2K5, PLA2G6, MAP2K6, MAPK11, MYC, NFKB2, TGFB2, ATF4, RELB, IL1A, CACNA2D2, DUSP4, CACNA2D1, MEF2C, FGF13, FGF2, RASGRP2, PDGFRA",0.247183568811729,0.134896025358872,FALSE +"proteomics","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.73187,-2.12,0.00499,9747,0.382,"HNF1A, HNF4A, NEUROD1, GCK, MNX1, PAX6",2.30189945437661,0.417936637088291,FALSE +"proteomics","Log2FC","KEGG_MELANOGENESIS",0.30698,0.863,0.626,3523,0.99,"GNAO1, TYR, CTNNB1, WNT5B, EP300, LEF1, KRAS, NRAS, WNT11, DVL1, CREBBP, CREB3L2, CREB3L1, PLCB1, HRAS, MAPK3, CAMK2D, WNT5A, TCF7L1, MAPK1, GNAI2, DVL3, GNAI3, ADCY9, CAMK2B, PLCB3, ADCY5, CREB1, PRKCG",0.20342566678957,0.00436480540245009,FALSE +"proteomics","Log2FC","KEGG_MELANOMA",-0.43,-1.27,0.183,10540,0.57,"CDK6, FGF13, FGF2, PDGFRA",0.737548910269571,0.244125144327509,FALSE +"proteomics","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.42413,-1.24,0.193,10663,0.551,"AKR1C1, GSTM2, AKR1C3, AKR1C2, GSTA4, ALDH3A1, CYP3A7",0.714442690992226,0.258848401148215,FALSE +"proteomics","Log2FC","KEGG_MISMATCH_REPAIR",0.43847,1.24,0.198,4177,0.577,"PCNA, LIG1, MLH3, RFC5, POLD4, EXO1, RFC2, RFC3, RFC1, RPA3, POLD3, RFC4",0.703334809738469,0.238824186844269,FALSE +"proteomics","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.42655,1.19,0.209,2845,0.638,"VEGFA, VEGFC, PIK3CD, CAB39, PDPK1, RPS6KA1, PIK3R2, RPS6KA6, HIF1A, PIK3CA, RPS6KA2, EIF4EBP1, MAPK3, RHEB, RPS6KB2, RICTOR, RPS6KA3, MAPK1",0.679853713888946,0.195179321278838,FALSE +"proteomics","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.48135,1.35,0.135,2561,0.576,"RAC2, ITGAL, ITGB2, LCK, RAET1L, ULBP2, NFATC4, SH3BP2, ICAM2, PIK3CD, RAC3, PTPN6, PPP3R1, VAV1, LCP2, PPP3CA, VAV2, IFNGR1, PPP3CB, PPP3R2, KRAS, NRAS, PTK2B, ICAM1, NFATC1, PIK3R2, RAC1, PIK3CA, HRAS, MAPK3, VAV3, GRB2, NFATC3, NFATC2, SOS2",0.869666231504994,0.239577516576788,FALSE +"proteomics","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.21798,-0.626,0.934,8815,1,"TACR1, LEPR, F2R, P2RY11, CTSG, GRM5, PRSS1",0.0296531237699066,0,FALSE +"proteomics","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.31617,0.884,0.596,2672,1,"ARHGDIB, BCL2, TP73, PRKCD, ZNF274, MAPK12, PIK3CD, MAPK13, IRS1, GAB1, PDPK1, MAP3K5, TRAF6, KRAS, NRAS, RPS6KA4, MAP3K1, RPS6KA1, MAGED1, RHOA, PIK3R2, RPS6KA6, TP53, RAC1, NTRK2, PIK3CA, IKBKB, RPS6KA2, HRAS, MAPK3, CAMK2D, NFKBIA, GRB2, SOS2, FRS2, MAPK14, SORT1",0.224753740259764,0,FALSE +"proteomics","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.48857,-1.46,0.0984,9003,0.555,"NMNAT3, NAMPT, NNT, NT5C, CD38, BST1, NNMT",1.00700490156866,0.255707016877324,FALSE +"proteomics","Log2FC","KEGG_NITROGEN_METABOLISM",-0.39831,-1.17,0.261,9727,0.569,"CA14, CA2, CA12, CPS1, CA8",0.583359492661719,0.244887733604929,FALSE +"proteomics","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.43448,1.21,0.206,2883,0.611,"CASP5, CXCL1, MAPK12, TRIP6, MAPK13, CASP1, TRAF6, IL18, IKBKB, MAPK3, NAIP, NFKBIA, TAB3, MAPK14, CASP8, CCL13, MAPK1, IL1B",0.686132779630847,0.213958789757446,FALSE +"proteomics","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.71762,-2.09,0.014,9253,0.224,"NHEJ1, PRKDC, RAD50, MRE11, POLL",1.85387196432176,0.649751981665837,TRUE +"proteomics","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.41063,1.17,0.245,2596,0.666,"RXRA, RXRG, TGFA, ERBB2, PIK3CD, EGFR, CDK4, PDPK1, CCND1, KRAS, NRAS, PIK3R2, TP53, PIK3CA, HRAS, MAPK3, GRB2, SOS2, CDKN2A",0.610833915635468,0.176525770829699,FALSE +"proteomics","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.34018,0.949,0.481,3178,0.931,"DTX3L, EP300, JAG1, NOTCH3, NCOR2, DVL1, CREBBP, DTX2, CTBP1, NUMB, HDAC1, MAML3, DVL3, RBPJ, JAG2",0.317854923626168,0.0310503190186574,FALSE +"proteomics","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.17811,-0.522,0.994,1956,0.992,"ERCC5, PCNA, RAD23B, LIG1, RFC5, POLD4, RFC2, RFC3, POLE, RFC1, RPA3, CUL4A, POLE4, POLD3, RFC4, RBX1, CETN2, POLE3, DDB1, MNAT1, POLD1, ERCC6, RAD23A, ERCC4, RPA2, POLE2, POLD2, RPA1, CDK7, GTF2H5, ERCC3, DDB2, CUL4B, GTF2H3, ERCC2, CCNH, GTF2H4, GTF2H1, GTF2H2, ERCC1, ERCC8, XPC, XPA",0.00261361560268669,0.00348832784582135,FALSE +"proteomics","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.47511,1.32,0.126,836,0.575,"MAN1C1, MGAT4A, ST6GAL1, B4GALT1, FUT8",0.899629454882437,0.24033215531037,FALSE +"proteomics","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",-0.37643,-1.12,0.267,9870,0.536,"CNGB1, PDE1C",0.573488738635425,0.27083521030723,FALSE +"proteomics","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.53605,-1.57,0.0641,8075,0.565,"MTHFD1L, ATIC, MTHFD2, MTHFS, MTFMT, TYMS, MTHFR, GART, ALDH1L1",1.19314197048118,0.247951552180562,FALSE +"proteomics","Log2FC","KEGG_OOCYTE_MEIOSIS",0.19709,0.561,0.981,3300,1,"MAPK12, PPP3R1, ANAPC11, PPP3CA, AR, AURKA, PPP3CB, PPP2R5E, CCNB1, PPP3R2, PPP2R5B, BUB1, RPS6KA1, RPS6KA6, RPS6KA2, MAPK3, CAMK2D, IGF1R, RPS6KA3, MAPK1, BTRC, YWHAB, ADCY9, PKMYT1, CAMK2B",0.0083309926200515,0,FALSE +"proteomics","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",-0.2091,-0.607,0.954,7256,1,"FUCA2, MAN2B1, HEXB, MAN2B2, AGA, MAN2C1, HEXA",0.0204516252959049,0,FALSE +"proteomics","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.46085,-1.35,0.12,7298,0.604,"NDUFV2, COX7C, NDUFS4, SDHB, NDUFB5, COX15, ATP6V1A, COX4I1, SDHC, COX6B1, COX6A1, NDUFV1, UQCRC1, ATP6V1B2, COX7A2, NDUFA6, NDUFC1, PPA1, ATP6V0A2, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, NDUFA2, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, NDUFA11, NDUFA3, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, ATP5MG, SDHD, NDUFS8, NDUFS2, ATP5F1C, ATP5F1B, ATP5PB, ATP5PD, NDUFB2, ATP5ME, ATP5MC2, COX11",0.920818753952375,0.218963061378868,FALSE +"proteomics","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.59998,1.69,0.0274,1847,0.861,"GCNT3, GALNT3, GALNT12, GALNT6, ST6GALNAC1, GALNT8, GALNT13, GALNT7, B4GALT5, GALNT2, GALNT15, GALNT5, C1GALT1C1, GALNT4, ST3GAL1",1.56224943717961,0.0649968485463452,FALSE +"proteomics","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.29693,0.833,0.667,1726,0.992,"TP73, SERPINB5, SESN3, THBS1, CHEK2, CDK4, CCND1, RCHY1, CCNB1, CDKN1A, EI24",0.175874166083451,0.00348832784582135,FALSE +"proteomics","Log2FC","KEGG_PANCREATIC_CANCER",0.39919,1.12,0.277,2405,0.72,"RAC2, VEGFA, TGFA, ERBB2, VEGFC, PIK3CD, RAC3, EGFR, CDK4, RALB, CCND1, STAT1, KRAS, PIK3R2, TP53, JAK1, RAC1, PIK3CA, STAT3, IKBKB, MAPK3",0.557520230935551,0.142667503568732,FALSE +"proteomics","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.26633,0.747,0.818,2657,1,"BCAT2, PANK1, DPYD",0.087246696328677,0,FALSE +"proteomics","Log2FC","KEGG_PARKINSONS_DISEASE",-0.47609,-1.38,0.11,7298,0.583,"NDUFV2, COX7C, NDUFS4, SDHB, NDUFB5, UBE2J2, COX4I1, SLC18A1, SDHC, COX6B1, COX6A1, CYCS, NDUFV1, UQCRC1, COX7A2, NDUFA6, NDUFC1, UBE2G2, UBE2G1, HTRA2, NDUFA7, NDUFA8, NDUFA4, NDUFS5, PARK7, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, SLC25A6, NDUFA2, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, VDAC1, NDUFA3, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, ATP5F1C, ATP5F1B, ATP5PB, SLC25A4, ATP5PD, NDUFB2, ATP5MC2, UCHL1",0.958607314841775,0.234331445240986,FALSE +"proteomics","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.24664,0.696,0.88,646,1,"LY96, CDH1, TUBA4A, CTNNB1",0.0555173278498314,0,FALSE +"proteomics","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.24197,0.682,0.892,2654,1,"RAC2, BCL2, CDH1, PTGS2, VEGFA, CTNNA1, LAMC2, LAMB3, RXRA, RXRG, TRAF4, CTNNA2, CTNNB1, TGFA, ERBB2, WNT5B, VEGFC, PIK3CD, RAC3, EP300, MECOM, RARA, RUNX1, ITGA2, LAMA3, LAMA4, NCOA4, EGFR, CKS1B, CDK4, RALB, SKP2, AR, LEF1, CCND1, STAT1, TRAF6, KRAS, NRAS, CDKN1A, ITGA3, WNT11, DVL1, FLT3, MAX, RHOA, MMP2, BCR, CREBBP, PIK3R2, TP53, JAK1, RAC1, PIAS3, HIF1A, MET, SLC2A1, PIK3CA, CTBP1, STAT3, IKBKB, HRAS, MAPK3, LAMB1, WNT5A, NFKBIA, CBLB, GRB2, IGF1R, SOS2, CDKN2A, TCF7L1, HDAC1, PAX8",0.0496351456238769,0,FALSE +"proteomics","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.39564,1.11,0.295,6667,0.696,"DCXR, UGP2, XYLB, UGDH, CRYL1, UGT2B11, UGT2B4, RPE, GUSB, AKR1B1",0.530177984021837,0.157390760389438,FALSE +"proteomics","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.50211,1.4,0.0899,829,0.567,"ALDOB, FBP1, ALDOC, FBP2",1.04624030826677,0.246416941107093,FALSE +"proteomics","Log2FC","KEGG_PEROXISOME",0.32858,0.939,0.513,2901,0.942,"FAR1, PXMP4, EPHX2, PEX13, MVK, ACSL4, ACOT8, ACAA1, AMACR, ACSL1, CAT, CRAT, ACOX1, SLC25A17, FAR2, SCP2, CROT, ACSL6, GSTK1, IDH2, ACOX3, ACSL5, PMVK, PEX7, NUDT12, ACSL3, ABCD3, IDH1, PXMP2",0.289882634888184,0.0259490972071227,FALSE +"proteomics","Log2FC","KEGG_PHENYLALANINE_METABOLISM",-0.44236,-1.29,0.164,10509,0.617,"MAOB, NAA80, ALDH3A1",0.785156151952302,0.209714835966758,FALSE +"proteomics","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.26615,0.753,0.807,2260,1,"IMPA2, DGKA, INPP4B, PIK3CD, PIP4K2C, CDS1, DGKH, DGKB, PIK3R2, PLCB1, PIK3C2B, PIK3CA, PI4KA, PLCD1",0.0931264652779296,0,FALSE +"proteomics","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.41459,-1.24,0.195,8765,0.551,"BLVRA, HMBS, PPOX, EARS2, BLVRB, HMOX1, ALAS1, UROD, UROS, FECH",0.709965388637482,0.258848401148215,FALSE +"proteomics","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.40642,1.12,0.316,1703,0.72,"CD36, PLTP, LPL, FADS2, FABP6, FABP2, RXRA, RXRG, SCD5, ACSL4, FABP3, APOC3, ACAA1, PDPK1, ACSL1, ACOX1, CPT2, SCP2, ACSL6, HMGCS2",0.500312917381596,0.142667503568732,FALSE +"proteomics","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.44792,1.25,0.176,1638,0.589,"CYP7B1, AMACR, SCP2",0.75448733218585,0.229884705212898,FALSE +"proteomics","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.32308,-0.948,0.459,9562,0.668,"RFX5, RFXAP, CD40, BLNK",0.338187314462739,0.175223537524454,FALSE +"proteomics","Log2FC","KEGG_PRION_DISEASES",-0.62081,-1.83,0.0157,10295,0.396,"C7, SOD1, C9, NCAM1, IL1A, NCAM2, EGR1",1.80410034759077,0.402304814074488,FALSE +"proteomics","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.25639,0.714,0.849,3263,1,"FZR1, MAPK12, PIK3CD, MAPK13, ANAPC11, CCNB1, KRAS, BUB1, CCNA2, RPS6KA1, PIK3R2, RPS6KA6, PIK3CA, RPS6KA2, MAPK3, IGF1R, MAPK14, RPS6KA3, MAPK1, GNAI2, GNAI3, CCNB3, ADCY9, PKMYT1",0.0710923097560473,0,FALSE +"proteomics","Log2FC","KEGG_PROPANOATE_METABOLISM",-0.26044,-0.775,0.737,10443,0.881,"ALDH2, ALDH7A1, ACSS3",0.132532512140949,0.0550240915879521,FALSE +"proteomics","Log2FC","KEGG_PROSTATE_CANCER",0.32384,0.919,0.535,2624,0.948,"BCL2, CTNNB1, TGFA, ERBB2, PIK3CD, EP300, EGFR, AR, LEF1, PDPK1, CCND1, KRAS, NRAS, CDKN1A, CREBBP, PDGFC, PIK3R2, CREB3L2, TP53, CREB3L1, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, GRB2, IGF1R, SOS2, TCF7L1",0.271646217978772,0.0231916626619338,FALSE +"proteomics","Log2FC","KEGG_PROTEASOME",0.2805,0.797,0.729,7310,0.996,"PSMB10, PSMB8, PSME2, PSME1, POMP, PSMB1, PSMB9, PSMA7, PSMA1, PSMA2, PSME3, PSMA8, PSMA3, PSMB2, PSMC6, PSMB3, PSMD7, PSME4, PSMA5, PSMB4, PSMA4, PSMD4, PSMD2, PSMB7, PSMD3, PSMD11, PSMC2, PSMC4, PSMC3, PSMC5, PSMF1, PSMD12, PSMD13, PSMA6, PSMC1, PSMB6, PSMD14, PSMD6, PSMD8, PSMD1, SEM1",0.137272471682025,0.00174066157630127,FALSE +"proteomics","Log2FC","KEGG_PROTEIN_EXPORT",-0.34994,-1.03,0.391,7823,0.653,"SEC61B, IMMP2L, SEC11C, SEC63, IMMP1L, SEC61A2",0.407823242604133,0.185086818724926,FALSE +"proteomics","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.28081,0.793,0.739,3930,0.993,"ATP1A2, GLUD2, AQP1, SLC38A3, ATP1A3, ATP1A4, ATP1A1, SLC9A3, PCK1, ATP1B1",0.131355561605174,0.00305075150461883,FALSE +"proteomics","Log2FC","KEGG_PURINE_METABOLISM",-0.26075,-0.758,0.763,7632,0.87,"PRIM2, PDE4D, POLA1, POLR3C, HPRT1, POLR2E, POLR3A, POLR3H, PDE8A, ENTPD4, GMPR2, POLA2, POLR2H, NUDT9, PNPT1, ATIC, NME2, ADCY3, ADCY8, PAPSS2, AK5, NUDT2, POLR3GL, GDA, POLR1E, GMPS, RRM2B, ADCY10, NPR2, GART, PFAS, NT5C, NME4, NUDT5, PDE3A, ADCY6, ENTPD1, PDE4A, NME1, NPR1, PDE1C, ENTPD8",0.11747546204512,0.0604807473813815,FALSE +"proteomics","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.20888,-0.598,0.967,7564,0.993,"POLR2A, AK3, PRIM2, DHODH, DCTD, POLA1, POLR3C, POLR2E, POLR3A, POLR3H, ENTPD4, POLA2, POLR2H, PNPT1, NME2, DTYMK, NUDT2, TYMS, POLR3GL, POLR1E, CAD, RRM2B, DUT, UCK2, NT5C, UMPS, NME4, TXNRD1, ENTPD1, CTPS1, NME1, ENTPD8",0.0145735259169983,0.00305075150461883,FALSE +"proteomics","Log2FC","KEGG_PYRUVATE_METABOLISM",-0.33889,-0.988,0.412,7380,0.677,"ACYP2, GRHPR, ACACA, PDHB, ALDH9A1, ME2, ALDH1B1, PDHA1, ACAT1, ALDH3A2, GLO1, PCK2, HAGH, ME3, ALDH2, ALDH7A1",0.385102783966865,0.169411331314856,FALSE +"proteomics","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.26341,0.759,0.781,1559,1,"ITGB6, RAC2, ITGAL, PAK5, PAK6, ITGB8, ITGB2, ACTN3, ITGB4, BAIAP2, SCIN, MYH14, PIK3CD, PIP4K2C, SLC9A1, RAC3, VAV1, GSN, ITGA2, ITGA11, EGFR, SSH3, VAV2, FGD3, ITGA4, KRAS, NRAS",0.1073489661227,0,FALSE +"proteomics","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.43145,-1.27,0.193,7210,0.57,"PIK3R4, ATG4B, ULK1, ATG5, PIK3C3, GABARAPL1, ATG3, ATG7, ULK3, PRKAA2",0.714442690992226,0.244125144327509,FALSE +"proteomics","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.3892,1.1,0.311,2561,0.704,"PAK5, PAK6, VEGFA, TGFA, VEGFC, PIK3CD, EP300, GAB1, KRAS, NRAS, CREBBP, PIK3R2, RAC1, HIF1A, MET, SLC2A1, PIK3CA, HRAS, MAPK3, GRB2, SOS2",0.507239610973163,0.152427340857888,FALSE +"proteomics","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.32703,-0.955,0.44,9197,0.682,"NLN, AGT, CTSG, ACE2",0.356547323513813,0.166215625343521,FALSE +"proteomics","Log2FC","KEGG_RETINOL_METABOLISM",-0.40251,-1.16,0.248,10576,0.551,"ALDH1A2, ALDH1A1, CYP3A7",0.605548319173784,0.258848401148215,FALSE +"proteomics","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",0.46483,1.31,0.152,593,0.537,"ACP5, MTMR7, TYR",0.818156412055227,0.270025714300444,FALSE +"proteomics","Log2FC","KEGG_RIBOSOME",-0.54955,-1.56,0.092,6763,0.519,"RPSA, RPS16, RPS26, MRPL13, RPL13, RPL11, RPS25, RPL37A, RPL35, RPS4X, RPL27, RPS21, RPS28, RPS27L, RPS15A, RPS2, RPL14, FAU, RPL23, RPL7A, RPL29, RPS29, RPL21, RPL5, RPL34, RPL22, RPS9, RPS3, RPS18, RPL17, RPL15, RPL8, RPL18A, RPS3A, RPS12, RPL28, RPS11, RPL36, RPS17, RPL36A, RPL36AL, RPL3, RPL13A, RPL32, RPL26, RPL27A, RPS8, RPL10A, RPS7, RPS24, RPL7, RPS23, RPL31, RPL9, RPS13, RPL35A, RPL18, RPL19, RPL24, RSL24D1, RPL4, RPS20, RPL6, RPL38, RPS6, RPL37, RPL26L1, RPS4Y1",1.03621217265444,0.284832642151542,FALSE +"proteomics","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.21434,0.603,0.954,1713,1,"ISG15, MAPK12, MAPK13, CASP10, DDX58, DHX58, TRAF6, MAP3K1",0.0204516252959049,0,FALSE +"proteomics","Log2FC","KEGG_RNA_DEGRADATION",-0.43669,-1.26,0.18,7190,0.562,"TTC37, EXOSC3, EXOSC2, EXOSC4, DIS3, EXOSC9, EXOSC5, EXOSC7, LSM2, PNPT1, EXOSC10, EXOSC8, LSM1, EXOSC1, MTREX, ENO3, HSPD1, HSPA9, PARN, TENT4A, DCP2, MPHOSPH6, DCPS, DCP1B",0.744727494896694,0.250263684430939,FALSE +"proteomics","Log2FC","KEGG_RNA_POLYMERASE",-0.42301,-1.21,0.209,5911,0.538,"POLR3F, POLR1B, POLR2D, POLR3K, POLR2B, POLR2G, POLR2C, POLR1A, POLR3B, POLR1C, POLR1D, POLR3D, POLR2L, POLR2I, POLR2A, POLR3C, POLR2E, POLR3A, POLR3H, POLR2H, POLR3GL, POLR1E",0.679853713888946,0.269217724333611,FALSE +"proteomics","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",0.26182,0.74,0.808,2085,1,"GGT5, CTH, METTL6, GGT7",0.0925886392254138,0,FALSE +"proteomics","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.31583,0.876,0.609,2488,0.986,"BCL2, PTGS2, LAMC2, LAMB3, RXRA, RXRG, TRAF4, PIK3CD, ITGA2, LAMA3, LAMA4, CKS1B, CDK4, SKP2, CCND1, TRAF6, ITGA3, MAX, PIK3R2, TP53, PIAS3, PIK3CA, IKBKB, LAMB1, NFKBIA",0.215382707367125,0.0061230850587888,FALSE +"proteomics","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.25505,0.72,0.836,3653,1,"VAMP8, VAMP4, TSNARE1, BET1L, STX17, SNAP47, STX3, GOSR1, STX10, SNAP29, STX16, STX18, STX12, STX6, VTI1B, SNAP23",0.0777937225609836,0,FALSE +"proteomics","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",0.29469,0.833,0.682,2465,0.992,"CERK, NEU1, UGT8, SGPP2, SPTLC2, GALC, PLPP3, DEGS1, SPTLC1",0.166215625343521,0.00348832784582135,FALSE +"proteomics","Log2FC","KEGG_SPLICEOSOME",-0.44795,-1.31,0.152,6622,0.608,"BCAS2, SNRPD1, SNRPD2, USP39, SF3A2, PRPF6, LSM3, THOC2, SNW1, SRSF6, SYF2, PQBP1, HNRNPA1, U2AF2, ACIN1, SNRPB2, MAGOHB, SRSF7, PRPF40A, HSPA8, HNRNPC, SNRPC, PPIL1, THOC1, RBM25, CTNNBL1, ZMAT2, SNRNP200, PRPF38B, HNRNPK, PRPF31, PPIH, HNRNPM, EIF4A3, DDX46, DDX39B, HNRNPA3, SF3A3, SRSF9, U2AF1, SRSF1, DDX23, SRSF4, SNRPA, SNRNP27, EFTUD2, SRSF8, PRPF38A, TRA2B, SNRPD3, DHX16, PPIE, SNRPF, SRSF3, LSM2, ALYREF, RBM8A, RBM17, SRSF2, SF3B4, TCERG1, RBMX, PRPF8, CDC40, U2SURP, SMNDC1, WBP11, RBM22, SNRNP40, SLU7, PRPF18, TRA2A, BUD31, SNU13, TXNL4A, CHERP, HNRNPU",0.818156412055227,0.216096420727265,FALSE +"proteomics","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.44846,1.26,0.169,2989,0.586,"HK1, SI, PYGB, PGM1, HK2, GAA, PGM2, AGL, PYGL, GYS1, UGP2, MGAM, PGM2L1",0.772113295386326,0.232102383981909,FALSE +"proteomics","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.72045,2,0.00945,2290,0.637,"DHCR24, MSMO1, FDFT1, CYP27B1, DHCR7, SC5D, SQLE, NSDHL, HSD17B7, CYP51A1, LSS",2.02456819149074,0.19586056766465,FALSE +"proteomics","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.44063,-1.31,0.152,10468,0.608,"AKR1D1, CYP21A2, AKR1C1, AKR1C3, AKR1C2, CYP3A7",0.818156412055227,0.216096420727265,FALSE +"proteomics","Log2FC","KEGG_SULFUR_METABOLISM",0.57977,1.63,0.0388,1903,0.638,"SULT2B1, SULT1A3, CHST12",1.41116827440579,0.195179321278838,FALSE +"proteomics","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.47545,-1.42,0.0956,9770,0.588,"CTSG, C7, CD40, C9, C1S",1.0195421077239,0.230622673923862,FALSE +"proteomics","Log2FC","KEGG_TASTE_TRANSDUCTION",0.39951,1.12,0.276,89,0.72,"SCNN1A",0.559090917934782,0.142667503568732,FALSE +"proteomics","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.5101,1.42,0.0899,2497,0.658,"HMGCS1, MVK, HMGCR, HMGCS2, PDSS2, PMVK, FDPS",1.04624030826677,0.181774106386044,FALSE +"proteomics","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.42677,-1.23,0.218,9929,0.525,"TGFB3, THBS4, THBS3, TGFB1, SMAD2, BMPR2, MYC, INHBA, FST, ACVR2A, TGFB2, BMPR1A, INHBE",0.661543506395395,0.279840696594043,FALSE +"proteomics","Log2FC","KEGG_THYROID_CANCER",0.56509,1.59,0.0464,2845,0.481,"CDH1, RXRA, RXRG, CTNNB1, NCOA4, LEF1, CCND1, KRAS, NRAS, TP53, HRAS, MAPK3, TCF7L1, PAX8, MAPK1",1.33348201944512,0.317854923626168,FALSE +"proteomics","Log2FC","KEGG_TIGHT_JUNCTION",0.5679,1.62,0.0411,1947,0.583,"CLDN18, CLDN4, CLDN7, CRB3, MYH7, PRKCH, EPB41L1, CGN, CLDN3, F11R, CLDN6, TJP3, ACTN3, CTNNA1, PRKCD, JAM2, PATJ, CTNNA2, CTNNB1, MYH14, MYH7B, TJP2, LLGL2, CDK4, MAGI3, PRKCQ, CASK, KRAS, NRAS, PRKCZ, PRKCI, CTTN, PARD6G, YES1, CLDN11, EXOC3, MYL9, RHOA, EXOC4",1.38615817812393,0.234331445240986,FALSE +"proteomics","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.24732,0.69,0.873,2883,1,"LY96, IRF5, MAPK12, PIK3CD, MAPK13, MYD88, STAT1, TRAF6, PIK3R2, RAC1, PIK3CA, IKBKB, MAPK3, NFKBIA, IKBKE, MAPK14, CASP8, MAPK1, IL1B",0.0589857562944303,0,FALSE +"proteomics","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",-0.38666,-1.12,0.273,10040,0.536,"WARS2, ALDH2, MAOB, ALDH7A1, AADAT, KYNU",0.563837352959244,0.27083521030723,FALSE +"proteomics","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",-0.31589,-0.922,0.531,10063,0.706,"MAPK8, GCK, SOCS2, SOCS4",0.274905478918531,0.151195298948196,FALSE +"proteomics","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",0.44767,1.26,0.167,1073,0.586,"CPE, PTPRN2, ICA1",0.777283528852417,0.232102383981909,FALSE +"proteomics","Log2FC","KEGG_TYROSINE_METABOLISM",0.29251,0.819,0.688,2304,0.986,"ADH4, ADH7, TYR, HGD, ALDH1A3, ALDH3B1, METTL6, ADH1C, COMT, TAT, MIF",0.162411561764489,0.0061230850587888,FALSE +"proteomics","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.50774,1.4,0.108,2664,0.567,"PAK5, PAK6, LCK, CARD11, MAPK12, NFATC4, PIK3CD, MAPK13, PTPN6, PPP3R1, VAV1, LCP2, CDK4, PPP3CA, VAV2, PDPK1, PPP3CB, PPP3R2, PRKCQ, KRAS, NRAS, RHOA, NFATC1, PTPRC, PIK3R2, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, CBLB, VAV3, GRB2, NFATC3, NFATC2, SOS2, TEC, MAPK14",0.96657624451305,0.246416941107093,FALSE +"proteomics","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.18021,0.513,0.99,2223,1,"FZR1, UBE2C, UBA7, UBE2E3, ANAPC11, TRIM37, SKP2, RCHY1, MGRN1, UBOX5, UBE2L6, KEAP1, TRAF6, MAP3K1, UBE2O, ITCH, UBA6, PIAS3, BRCA1",0.00436480540245009,0,FALSE +"proteomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.33808,-0.967,0.452,7753,0.673,"PDHB, PDHA1, LARS2, BCAT1",0.344861565188618,0.171984935776023,FALSE +"proteomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.25067,0.696,0.885,2361,1,"ABAT, HMGCS1, ALDH6A1, ACAD8, ACAA1, BCAT2, HMGCS2, MCCC1, HIBADH, ACADM, DBT, ACADS",0.0530567293021746,0,FALSE +"proteomics","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.285,-0.832,0.653,9514,0.793,"NPR2, ITPR1, PLCB2, ARHGEF11, ARHGEF1, PLCB4, PLA2G6, ADCY6, NPR1, CALD1, KCNMA1, PPP1R14A",0.185086818724926,0.100726812682396,FALSE +"proteomics","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.2868,0.789,0.715,2159,0.989,"ARHGDIB, AQP3, DYNLL2, RAB11B, CREB3L2, CREB3L1, RAB11A",0.145693958198919,0.0048037084028206,FALSE +"proteomics","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.53564,1.52,0.0683,2664,0.544,"RAC2, PTGS2, VEGFA, HSPB1, MAPK12, NOS3, NFATC4, PIK3CD, MAPK13, PLA2G12A, RAC3, PPP3R1, PPP3CA, PLA2G2A, PPP3CB, PPP3R2, KRAS, NRAS, NFATC1, PIK3R2, MAPKAPK3, RAC1, PIK3CA, HRAS, MAPK3, NFATC3, NFATC2, MAPK14",1.16557929631847,0.26440110030182,FALSE +"proteomics","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",0.14569,0.411,0.998,1695,1,"TJP2, ERO1A, PDIA4, KDELR3",0.000869458712628891,0,FALSE +"proteomics","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.40292,1.11,0.283,1355,0.696,"RAC2, MYH7, ITGAL, ITGB2, MYH14, MYH7B, RAC3, SGCG, CCND1",0.54821356447571,0.157390760389438,FALSE +"proteomics","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.29792,0.819,0.669,2624,0.986,"RAC2, VANGL2, SFRP4, CTNNB1, NFATC4, WNT5B, DAAM1, RAC3, 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Garana, belinda.garana@pnnl.gov +# Created: 2024-01-17 +# Last edit: 2024-01-17 +### We will perturb gene expression and drug AUC in the same directions, then +### leave out 1 cell line 100 different times to run mDMEA_cell_corr +### for 2 different cases: 200 cell lines and 20 cell lines + +### Step 1: Simulate gene expression for 200 OR 20 cell lines representative of +### CCLE normalized RNAseq version 19Q4, then perturb 1 set of 25 genes +### Step 2: Simulate drug AUC for 200 cell lines representative of PRISM, then +### perturb 1 drug set of 10 drugs +/- Y +### Step 3: 100 times: remove 1 random cell line to create input lists +### Step 4: Run mDMEA_cell_corr across the perturbations +### Step 5: Repeat 20 times + +rm(list=ls(all=TRUE)) +library(DMEA);library(dplyr);library(GSA);library(reshape2);library(data.table); +library(ggplot2);library(stringr);library(dostats); + +### Step 0: Prep rows, columns, values +# Import pathways +drug.sets <- GSA.read.gmt(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Simulations/DMEA_using_WGV/MOA_gmt_file_n6_w_synthetic_set.gmt") +pathway.names <- drug.sets$geneset.names +num.pathways <- length(pathway.names) + +# Import CCLE RNAseq data for gene list +download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin", + destfile = "Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin") +load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin") +download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin", + destfile = "Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin") +load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin") +CCLE.RNAseq <- rbind(RNA.first200, RNA.rest) +gene.names <- unique(colnames(CCLE.RNAseq[,2:ncol(CCLE.RNAseq)])) +num.genes <- length(gene.names) #19144 + +# Make a synthetic gene set of size 25 genes +gene.set.size <- 25 +#synthetic.gene.set <- sample(gene.names,gene.set.size) #we did this once and now we want to use the same gene set for each time, so lets save it separately +synthetic.gene.set <- c("HDAC11","FSBP","PGF","NBEAL2","SMIM15","PRSS33","USP29","ZCCHC7","PIK3C2B","ZFAND2B","CLMP","APOL4","TXNIP", + "LRRC41","ARHGEF38","KRT85","TMEM121","DPYSL2","DAZ4","C1QA","CILP","AFF2","CHAC2","BLVRA","RNF114") + +#Import PRISM data for drug list +prism <- read.csv(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/PRISM_drug_mean_AUC_6-23-21.csv",header=T) +prism$X <- NULL + +#Make a synthetic drug set of size 10 drugs - already done in "Metabolic Pathways and the drugs that target them - filtered - gmt.gmt" +drug.set.size <- 10 +#synthetic.drug.set <- sample(drug.names,drug.set.size) # we did this once and now we want to use the same gene set for each time, so lets save it separately + +synthetic.drug.set <- c("blebbistatin....","BI.D1870","PF.05212384","oligomycin.a","levonorgestrel","norfloxacin","poziotinib", + "estradiol","CGP.54626","epirubicin") + +# Make synthetic cell line names +synthetic.cell.names <- seq(from = 1, to = 200, by = 1) +synthetic.cell.names <- paste("Cell_No_", synthetic.cell.names, sep = "") + +# How far do we want to vary values here? +values.to.vary <- seq(from = 0, to = 0.1, by = 0.01) + +# Import drug info +drug.info <- read.csv(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/PRISM_secondary-screen-replicate-treatment-info.csv",header=T) #481 cell lines +colnames(drug.info)[colnames(drug.info)=="name"] <- "Drug" +drug.info$Drug <- gsub("[[:punct:][:blank:]]",".",drug.info$Drug) +drug.moa <- na.omit(distinct(drug.info[,c("Drug","moa")])) +Drug <- unique(drug.moa$Drug) +moa.drugs <- data.frame(Drug) +Drug <- unique(colnames(prism[,2:ncol(prism)])) +prism.drugs <- data.frame(Drug) +overlap.drugs <- merge(moa.drugs,prism.drugs,by="Drug") + +# reduce PRISM data to drugs with moa +prism <- prism %>% select("CCLE_ID",overlap.drugs$Drug) +drug.names <- unique(colnames(prism[,2:ncol(prism)])) +num.drugs <- length(drug.names) #1351 + +# set drug AUC parameters +frac.low.AUC <- 0.72 +num.drugs.low <- round(frac.low.AUC*num.drugs,digits=0) #973 +num.drugs.high <- round((1-frac.low.AUC)*num.drugs,digits=0) #378 +num.synth.drugs.low <- round(frac.low.AUC*drug.set.size,digits=0) #7 +num.synth.drugs.high <- round((1-frac.low.AUC)*drug.set.size,digits=0) #3 +low.mean.AUC <- 0.83 +low.sd.AUC <- 0.1657471 +high.mean.AUC <- 1.31 +high.sd.AUC <- 0.1580992 +half.low.sd.AUC <- 0.08 +half.high.sd.AUC <- 0.08 + +# Run simulations (N replicates) +N.max <- 20 +for (N in 1:N.max){ + loop.start.time <- Sys.time() + + ### Step 1: Generate gene expression matrix for 200 cell lines and 25 genes in synthetic gene set + # Step 1a: make gene expression matrix + expr.matrix <- matrix(data = NA, nrow = gene.set.size, ncol = length(synthetic.cell.names)+1) + row.names(expr.matrix) <- synthetic.gene.set + colnames(expr.matrix) <- c("Gene",synthetic.cell.names) + expr.matrix[,"Gene"] <- synthetic.gene.set + expr.matrix <- as.data.frame(expr.matrix) + + # Step 1b: make list of varied value expression matrices + expr.matrices <- list() + varied.value.names.all <- paste("value_added_",values.to.vary, sep = "") + + # Step 1c: replace values of synthetic gene set with varied values (perturbation); Need to do 0 separately + varied.value <- values.to.vary[1] + varied.value.name <- paste("value_added_",varied.value, sep = "") + for (k in 1:length(synthetic.cell.names)){ + expr.matrix[expr.matrix$Gene %in% synthetic.gene.set, synthetic.cell.names[k]] <- rnorm(length(synthetic.gene.set), mean = 0, sd = 0.5) + } + expr.matrices[[varied.value.names.all[1]]] <- expr.matrix + + for(j in 2:length(values.to.vary)){ + varied.value <- values.to.vary[j] + varied.value.name <- paste("value_added_",varied.value, sep = "") + + range.to.vary <- seq(from = -varied.value, to = varied.value, by = 2*varied.value / (length(synthetic.cell.names)-1)) + for (k in 1:length(synthetic.cell.names)){ + expr.matrix[expr.matrix$Gene %in% synthetic.gene.set, synthetic.cell.names[k]] <- rnorm(length(synthetic.gene.set), mean = range.to.vary[k], sd = 0.5) + } + expr.matrices[[varied.value.names.all[j]]] <- expr.matrix + } + + ### Step 3: Generate drug AUC that have a normal distribution for each cell line, then perturb synthetic drug set + AUC.matrix <- matrix(data = NA, nrow = length(drug.names), ncol = length(synthetic.cell.names)+1) + row.names(AUC.matrix) <- drug.names + colnames(AUC.matrix) <- c("Drug",synthetic.cell.names) + AUC.matrix[,"Drug"] <- drug.names + AUC.matrix <- as.data.frame(AUC.matrix) + # Fill out matrix with normal distribution of rank values + # And replace synthetic drug set with a value of X + + for(i in 1:length(synthetic.cell.names)){ + temp.cell <- synthetic.cell.names[i] + normal.low <- rnorm(num.drugs.low, mean=low.mean.AUC, sd=half.low.sd.AUC) + normal.high<- rnorm(num.drugs.high, mean=high.mean.AUC, sd=half.high.sd.AUC) + normal <- c(normal.low,normal.high) + AUC.matrix[,temp.cell] <- normal + } + + + AUC.matrices <- list() + + ## Need to do 0 separately + varied.value <- values.to.vary[1] + varied.value.name <- paste("value_added_",varied.value, sep = "") + for (k in 1:length(synthetic.cell.names)){ + normal.low <- rnorm(num.synth.drugs.low, mean=low.mean.AUC, sd=half.low.sd.AUC) + normal.high<- rnorm(num.synth.drugs.high, mean=high.mean.AUC, sd=half.high.sd.AUC) + normal <- c(normal.low,normal.high) + AUC.matrix[synthetic.drug.set, synthetic.cell.names[k]] <- normal + } + AUC.matrices[[varied.value.name]] <- AUC.matrix + + for(j in 2:length(values.to.vary)){ + varied.value <- values.to.vary[j] + varied.value.name <- paste("value_added_",varied.value, sep = "") + + range.to.vary <- seq(from = -varied.value, to = varied.value, by = 2*varied.value / (length(synthetic.cell.names)-1)) #from0 BG 20210913 + for (k in 1:length(synthetic.cell.names)){ + normal.low <- rnorm(num.synth.drugs.low, mean=low.mean.AUC+range.to.vary[k], sd=half.low.sd.AUC) + normal.high<- rnorm(num.synth.drugs.high, mean=high.mean.AUC+range.to.vary[k], sd=half.high.sd.AUC) + normal <- c(normal.low,normal.high) + AUC.matrix[synthetic.drug.set, synthetic.cell.names[k]] <- normal + } + AUC.matrices[[varied.value.name]] <- AUC.matrix + } + + ### Step 4: Generate data lists for mDMEA_cell_corr input + expr.matrix.names <- names(expr.matrices) + AUC.matrix.names <- names(AUC.matrices) + + correlation.matrices <- list() + print("Generating Correlation Coefficients") + for(i in 1:length(expr.matrix.names)){ + for (j in 1:length(AUC.matrix.names)){ + expr.value <- paste("expr_",expr.matrix.names[i],sep = "") + AUC.value <- paste("AUC_",AUC.matrix.names[j], sep = "") + + corr.name <- paste(expr.value,"WGV", AUC.value,"correlation", sep = "_") + + temp.WGV.results <- WGV.scores.all.var[[expr.matrix.names[i]]] + temp.AUC.matrix <- AUC.matrices[[AUC.matrix.names[j]]] + temp.AUC.matrix$Drug <- NULL + temp.AUC.matrix <- t(temp.AUC.matrix) + input.df <- cbind(temp.WGV.results,temp.AUC.matrix) + + temp.corr <- rank.corr(data=input.df,variable="Drug",value="AUC",plots=F)$result + correlation.matrices[[corr.name]] <- temp.corr + } + } + + ##### Step 5: Run mDMEA_cell_corr + print("Running DMEA") + result.matrices <- list() + Correlation <- names(correlation.matrices) + synthetic.results <- as.data.frame(Correlation) + synthetic.results$ES <- NA + synthetic.results$NES <- NA + synthetic.results$p <- NA + synthetic.results$q <- NA + drugSEA.start.time <- Sys.time() + + corr.name <- names(correlation.matrices[i]) + temp.corr <- correlation.matrices[[corr.name]] + temp.result <- panSEA::mDMEA_cell_corr(gmt = drug.sets, expression = expr, + weights = weights, types = perts, + scatter.plots = FALSE) + result.matrices[[corr.name]] <- temp.result$compiled.results$results + # store synth drug set results in a separate df and save that + synthetic.results[synthetic.results$Correlation==corr.name,]$ES <- temp.result[temp.result$Drug.Set=="Synthetic_Drug_Set",]$ES + synthetic.results[synthetic.results$Correlation==corr.name,]$NES <- temp.result[temp.result$Drug.Set=="Synthetic_Drug_Set",]$NES + synthetic.results[synthetic.results$Correlation==corr.name,]$p <- temp.result[temp.result$Drug.Set=="Synthetic_Drug_Set",]$p_value + synthetic.results[synthetic.results$Correlation==corr.name,]$q <- temp.result[temp.result$Drug.Set=="Synthetic_Drug_Set",]$FDR_q_value + + all.results <- rbindlist(result.matrices,use.names=TRUE,idcol="correlation",fill=TRUE) + write.csv(all.results,file=paste0(N,"_", drugSEA.start.time,"_all_drugSEA_results.csv")) + write.csv(synthetic.results,file=paste0(N,"_", drugSEA.start.time,"_Synthetic_Drug_Set_drugSEA_results.csv")) +} + +#### Run mDMEA_cell_corr +mDMEA.results <- panSEA::mDMEA_cell_corr(expression = expr, weights = weights, + types = seq(1, length(weights))) +#utils::write.csv(mDMEA.results$compiled.results$) + + +## Generate tile plots +# Load themes for plots +ng.theme <- theme(panel.grid.major = element_blank(), panel.grid.minor = element_blank(), + panel.border = element_rect(fill=NA), panel.background = element_blank(), + axis.line = element_line(colour = "black"), axis.text.x = element_text(colour = "black"), + axis.text.y = element_text(colour = "black"), axis.ticks.x = element_line(colour="black"), + axis.ticks.y = element_line(colour="black"), legend.title = element_blank(), + axis.title.y = element_text(size=8, colour="black")) + +bg.theme <- theme(legend.background = element_rect(), legend.position="top", legend.text = element_text(size=14), legend.key = element_blank(), + axis.title.x = element_text(size=20), axis.text.x = element_text(size=16), + axis.title.y = element_text(size=20), axis.text.y = element_text(size=16), + plot.title = element_text(lineheight=.8, face="bold", size=36)) + +# import results +sim.results <- import_list(dir(pattern = "Synthetic_Drug_Set_drugSEA_results.csv$")) + +# rbind all dataframes in sim.resuls; make sure you only use N.max replicates +plot.data <- rbindlist(sim.results,use.names=TRUE,idcol="file",fill=TRUE) + +# formatting: make columns for replicate number N, expr.value, and AUC.value +expr.values <- seq(0,0.1,0.01) +AUC.values <- seq(0,0.1,0.01) +for (i in 1:nrow(plot.data)){ + plot.data$N[i] <- substring(plot.data$file[i],1,2) + plot.data$expr.string[i] <- substring(plot.data$Correlation[i],1,23) + for (j in 1:length(expr.values)){ + if (grepl(expr.values[j], plot.data$expr.string[i], fixed=TRUE)==TRUE) { + plot.data$expr.value[i] <- expr.values[j] + } + } + plot.data$AUC.string[i] <- substring(plot.data$Correlation[i],24,50) + for (k in 1:length(AUC.values)){ + if (grepl(AUC.values[k], plot.data$AUC.string[i], fixed=TRUE)==TRUE){ + plot.data$AUC.value[i] <- AUC.values[k] + } + } +} + +#For each correlation, average NES and count nrow q<0.05 and divide by N.max for percent +plot.data[,c("Average.NES","SD.NES", + "Average.q","SD.q", + "percent.q0.05","percent.q0.25")] <- NA +Correlations <- unique(plot.data$Correlation) +for(i in 1:length(Correlations)){ + temp.data <- plot.data[plot.data$Correlation==Correlations[i],] + reps.q0.05 <- nrow(temp.data[temp.data$q<0.05,]) + reps.q0.25 <- nrow(temp.data[temp.data$q<0.25,]) + for(j in 1:nrow(plot.data)){ + if(plot.data$Correlation[j]==Correlations[i]){ + plot.data$Average.NES[j] <- mean(temp.data$NES) + plot.data$SD.NES[j] <- sd(temp.data$NES) + plot.data$Average.q[j] <- mean(temp.data$q) + plot.data$SD.q[j] <- sd(temp.data$q) + plot.data$percent.q0.05[j] <- as.numeric(reps.q0.05*100/N.max) + plot.data$percent.q0.25[j] <- as.numeric(reps.q0.25*100/N.max) + } + } +} +write.csv(plot.data,file="WGV_drugSEA_sim_N50.csv") +plot.data <- read.csv(file = "WGV_drugSEA_sim_N50.csv") +plot.data$X <- NULL + +q0.05.tile.plot <- ggplot(plot.data, aes(x = expr.value, y = AUC.value, fill = percent.q0.05)) + + geom_tile() + ng.theme + theme_light() + scale_fill_gradient2()+ + labs(x = "Expression Value Added", y = "AUC Value Added", fill = "% q<0.05") +ggsave(a0.05.tile.plot, file = paste0("WGV_drugSEA_sim_q0.05_N50_",Sys.Date(),".pdf")) + +q0.25.tile.plot <- ggplot(plot.data, aes(x = expr.value, y = AUC.value, fill = percent.q0.25)) + + geom_tile() + ng.theme + theme_light() + scale_fill_gradient2() + + labs(x = "Expression Value Added", y = "AUC Value Added", fill = "% q<0.25") +ggsave(q0.25.tile.plot, file = paste0("WGV_drugSEA_sim_q0.25_N50_",Sys.Date(),".pdf")) + +NES.tile.plot <- ggplot(plot.data, aes(x = expr.value, y = AUC.value, fill = Average.NES)) + + geom_tile() + ng.theme + theme_light() + scale_fill_gradient2() + + labs(x = "Expression Value Added", y = "AUC Value Added", fill = "Mean NES") +ggsave(NES.tile.plot, file = paste0("WGV_drugSEA_sim_NES_N50_",Sys.Date(),".pdf")) diff 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+
+ + + + diff --git a/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_mean_results.csv b/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..7b177bc --- /dev/null +++ b/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"estrogen receptor antagonist",0.938666666666667,0.812267570484385,0.0755446994908814,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.169465136695761 +"RAF inhibitor",0.833583333333333,1.26394558702885,0.000634798367640633,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1650, HCC15",0.00463403912041291 +"HMGCR inhibitor",0.771583333333333,1.84500926128907,5.70283908159064e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,8,"HCC95, H1975, H1648, H2126, H520, H1299, HCC44, H1703",0.000788892739620038 +"MEK inhibitor",0.528666666666667,1.53185415477948,0.000837391696407067,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"H1650, H520, H1299, HCC44, H1703",0.00534642390782974 +"retinoid receptor agonist",0.481916666666667,1.16933076884588,0.0437670250085092,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"A549, HCC15",0.125264243989871 +"MDM inhibitor",0.4485,1.59347148190244,4.25355268913963e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,6,"H1650, HCC95, H1975, H1648, H460, A549",0.000706089746397179 +"phosphatase inhibitor",0.4395,1.07369146575558,0.248207912880679,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.420433811614211 +"FGFR inhibitor",0.387666666666667,1.281455375262,0.00664508424083666,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0290285258941812 +"TGF beta receptor inhibitor",0.358583333333333,1.21224678393119,0.0626923178535714,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.15768067823777 +"proteasome inhibitor",0.320916666666667,1.26328341729963,0.0459586121813373,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.127152160368367 +"BCL inhibitor",0.301666666666667,1.09352817923814,0.381650911659745,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.586611586439978 +"benzodiazepine receptor agonist",0.283416666666667,0.64442567218392,0.999978960984347,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"Bcr.Abl kinase inhibitor",0.259333333333333,1.20547857967722,0.107871548259925,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.213174726323185 +"dopamine receptor antagonist",0.252083333333333,0.753093916433865,0.999339740354943,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"cytochrome P450 inhibitor",0.252,1.30330984246055,0.027640697076093,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1975, H520",0.0943968065736886 +"sterol demethylase inhibitor",0.243083333333333,1.02981070266983,0.613435386057225,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.834674377749995 +"glutamate receptor antagonist",0.242666666666667,0.780693320456926,0.996581379921905,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"antioxidant",0.194666666666667,1.46971842283624,0.000357615200054215,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC95, H520",0.00296820616044998 +"glycogen synthase kinase inhibitor",0.17875,1.00492850265805,0.71681209770462,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.915313909376668 +"EGFR inhibitor",0.164,2.01796999707402,1.02226994967334e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,8,"H1650, HCC95, H1648, H2126, H460, H1299, HCC44, H1703",4.24242029114436e-05 +"CC chemokine receptor antagonist",0.142083333333333,1.21710277883276,0.107213326185498,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.213174726323185 +"p38 MAPK inhibitor",0.136916666666667,1.26161876235064,0.0616777878375922,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.15768067823777 +"bromodomain inhibitor",0.122583333333333,1.56627075671269,0.00228372303283276,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1975, H2126, H520, A549",0.0118468132328199 +"FLT3 inhibitor",0.117166666666667,1.22305495552834,0.10069845007875,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.213174726323185 +"acetylcholine receptor agonist",0.116416666666667,1.01375032414149,0.75980822126336,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.953314960428649 +"HDAC inhibitor",0.1095,1.15191843934763,0.239902583893652,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.414831551316106 +"Abl kinase inhibitor",0.0981666666666666,1.23109048728304,0.125656508375152,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.242546283607851 +"ALK tyrosine kinase receptor inhibitor",0.0893333333333333,0.9524480738252,0.854388021410793,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"RET tyrosine kinase inhibitor",0.0759166666666666,1.13713887041384,0.374133295791199,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.585906859446594 +"KIT inhibitor",0.06825,1.05696487642684,0.655695650715209,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.877786113054231 +"progesterone receptor agonist",0.0576666666666666,1.07865491434584,0.591637672409614,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.818432113499966 +"thymidylate synthase inhibitor",0.0526666666666666,1.17178367017849,0.186244240454619,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.336049390385507 +"DNA methyltransferase inhibitor",0.0505833333333332,1.30340675701886,0.028432773064364,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0943968065736886 +"adenosine receptor antagonist",0.0469166666666666,1.32520636186035,0.0390165275184611,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, H1299",0.11565613514401 +"PPAR receptor agonist",0.0341666666666667,1.26272568339887,0.104276690416759,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.213174726323185 +"PDGFR tyrosine kinase receptor inhibitor",0.0330833333333333,1.08845256783391,0.575118498540578,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.80906500642149 +"NFkB pathway inhibitor",0.0246666666666666,0.943177447233391,0.840310215094819,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"ribonucleotide reductase inhibitor",0.0115,1.4155775242892,0.00066998155957777,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.00463403912041291 +"DNA inhibitor",-0.0166666666666667,1.08916184066075,0.516155512514938,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.739773128304602 +"CHK inhibitor",-0.0320833333333334,1.2437361937714,0.0941909562139649,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.205732878046292 +"glucocorticoid receptor agonist",-0.0551666666666667,1.23375036765829,0.0729791077069916,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1648",0.169465136695761 +"acetylcholine receptor antagonist",-0.0606666666666666,1.26701541451004,0.0480719193509948,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1975, HCC44",0.128708687294599 +"AKT inhibitor",-0.0868333333333334,1.37173478972188,0.00902883832716294,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H2126",0.0374696790577262 +"histamine receptor antagonist",-0.0944166666666667,0.64817063667095,0.999995436991143,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"bacterial DNA gyrase inhibitor",-0.121666666666667,0.992845894233828,0.856983740217977,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"PI3K inhibitor",-0.13025,1.0086634833914,0.769543401791801,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.953314960428649 +"AP inhibitor",-0.137916666666667,1.44355932953197,0.0349841869698851,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1975, H520",0.107543982166684 +"src inhibitor",-0.138166666666667,1.58534090588705,1.08615873888801e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H1648, H1299",0.000300503917759017 +"JAK inhibitor",-0.15575,1.03324863900225,0.684255729282274,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.89465605220786 +"tyrosine kinase inhibitor",-0.163,1.0740078719874,0.516949896887553,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.739773128304602 +"adrenergic receptor agonist",-0.19025,0.877261350609228,0.96655412806198,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"opioid receptor agonist",-0.219583333333333,1.30280937406495,0.0184367518084397,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0728690666714521 +"calcium channel blocker",-0.224333333333333,0.858048455225666,0.982951592666599,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"adrenergic receptor antagonist",-0.239583333333333,0.798094031636206,0.99600164766268,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"estrogen receptor agonist",-0.247916666666667,0.863468213694405,0.974966016321922,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"protein synthesis inhibitor",-0.250833333333333,1.07899825876794,0.417290974443844,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.627257032595461 +"phosphodiesterase inhibitor",-0.25275,0.953819129509459,0.833992240948792,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"potassium channel blocker",-0.25475,1.19312219331543,0.0743316828226574,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.169465136695761 +"growth factor receptor inhibitor",-0.292666666666667,1.18552974989192,0.423209564160793,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.627257032595461 +"HCV inhibitor",-0.292833333333333,1.08417726102946,0.174514851331837,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.328305876406098 +"androgen receptor antagonist",-0.304916666666667,1.35770698795856,0.00194866276969976,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"A549, HCC15",0.0107826006590053 +"VEGFR inhibitor",-0.3315,0.79681895970506,0.991670553209632,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"mTOR inhibitor",-0.331666666666667,0.970972833000101,0.689855269172325,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.89465605220786 +"sodium channel blocker",-0.343583333333333,0.759390240837205,0.991572234561469,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"vitamin D receptor agonist",-0.352333333333333,1.5597269186002,0.00422355207943146,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1650, H1648, H2126, H1299",0.0194752679218228 +"MET inhibitor",-0.353666666666667,1.23811112244223,0.0748132377914362,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1975",0.169465136695761 +"DNA polymerase inhibitor",-0.373166666666667,0.784563321893527,0.974974764496359,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"PARP inhibitor",-0.376333333333333,1.24471386513552,0.0211405037498602,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0797573550562907 +"serotonin receptor antagonist",-0.41125,1.04687206173265,0.3392220471014,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.552067253125807 +"DNA alkylating agent",-0.458333333333333,1.01224892135674,0.3574509793029,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.570546755425783 +"DNA synthesis inhibitor",-0.479166666666667,1.08029969186445,0.177997161906921,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.328305876406098 +"Aurora kinase inhibitor",-0.50125,1.22597324047617,0.00288287002929136,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H520, H460",0.0140751889665402 +"protein tyrosine kinase inhibitor",-0.525416666666667,1.40441644033342,0.000155906453236167,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1650, HCC95, H1648, H2126",0.00177371350651608 +"CDK inhibitor",-0.52975,1.02307843163304,0.238796469601602,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.414831551316106 +"cyclooxygenase inhibitor",-0.5975,0.509132506417444,0.999228103756499,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143 +"PLK inhibitor",-0.67075,1.50143126413069,9.93557130269627e-09,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1650, HCC95, H460, H1299",8.2465241812379e-07 +"topoisomerase inhibitor",-0.67075,1.29210308658545,0.000961733121658294,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H520, H1299, H1703",0.00570170350697417 +"tubulin polymerization inhibitor",-0.696,1.23871164742023,0.000192330380224635,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, H1299",0.00177371350651608 +"ATPase inhibitor",-0.702833333333333,1.06228115036663,0.022769525011834,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1299",0.0821682859122704 +"microtubule inhibitor",-0.7275,1.23460715135699,0.00017633888442379,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1975, H460, H1299",0.00177371350651608 +"serotonin receptor agonist",-0.857916666666667,1.24817950765638,3.16381470352771e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1975",0.000656491550982 +"bacterial 50S ribosomal subunit inhibitor",-0.96125,0.562682879362144,0.323019942674153,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.536213104839093 +"HSP inhibitor",-1.065,0.670547808613497,0.0348763103016587,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1975",0.107543982166684 diff --git a/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_results.csv b/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_results.csv new file mode 100644 index 0000000..d79ee1c --- /dev/null +++ b/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_results.csv @@ -0,0 +1,997 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"H1650","Pearson.est","EGFR inhibitor",-0.80693,-2.22,0,1340,0.0199,"AEE788, rociletinib, WZ8040, TAK.285, vandetanib, CP.724714, brigatinib, pelitinib, gefitinib, afatinib, GW.583340, ARRY.334543, erlotinib, icotinib, dacomitinib, PD.168393, BMS.599626, XL.647, tucatinib, neratinib, AZD8931, lapatinib, BMS.690514, osimertinib, canertinib, poziotinib",Inf,1.70114692359029,TRUE +"H1650","Pearson.est","Abl kinase inhibitor",0.49473,1.18,0.276,122,0.676,"bafetinib, tozasertib, ponatinib, KW.2449, GZD824",0.559090917934782,0.170053304058364,FALSE +"H1650","Pearson.est","acetylcholine receptor agonist",0.63145,1.51,0.062,396,0.432,"oxiracetam, xanomeline, tremorine",1.20760831050175,0.364516253185088,FALSE +"H1650","Pearson.est","acetylcholine receptor antagonist",-0.23994,-0.661,0.862,346,1,"diphemanil, iododexetimide, hyoscyamine, dicycloverine, methscopolamine, darifenacin",0.0644927341752872,0,FALSE +"H1650","Pearson.est","adenosine receptor antagonist",-0.41868,-1.15,0.292,1377,0.636,"theophylline, MRS.1220, CGS.15943",0.534617148551582,0.196542884351586,FALSE +"H1650","Pearson.est","adrenergic receptor agonist",-0.29781,-0.801,0.712,1296,0.987,"isoxsuprine, lidamidine, xylazine",0.147520006363144,0.00568284733036327,FALSE +"H1650","Pearson.est","adrenergic receptor antagonist",0.25222,0.624,0.891,467,1,"carvedilol, oxprenolol, idazoxan, atipamezole, atenolol......, atenolol....",0.0501222959631252,0,FALSE +"H1650","Pearson.est","AKT inhibitor",-0.50358,-1.42,0.109,1229,0.442,"AZD5363, GSK2110183, CCT128930, triciribine, GDC.0068",0.962573502059376,0.354577730650908,FALSE +"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.24489,-0.687,0.851,1203,1,"SB.505124, GW.788388, AP26113, brigatinib",0.0700704399154121,0,FALSE +"H1650","Pearson.est","androgen receptor antagonist",-0.43636,-1.17,0.251,1250,0.667,"flutamide, RU.58841",0.600326278518962,0.175874166083451,FALSE +"H1650","Pearson.est","antioxidant",0.4516,1.08,0.37,321,0.677,"mesna, trolox, benfotiamine",0.431798275933005,0.169411331314856,FALSE +"H1650","Pearson.est","AP inhibitor",-0.55744,-1.53,0.079,1349,0.358,"birinapant, tanshinone.i, GDC.0152",1.10237290870956,0.446116973356126,FALSE +"H1650","Pearson.est","ATPase inhibitor",-0.41549,-1.12,0.323,1357,0.631,"omeprazole, digitoxigenin, k.strophanthidin",0.490797477668897,0.199970640755866,FALSE +"H1650","Pearson.est","Aurora kinase inhibitor",0.6135,1.5,0.054,377,0.407,"tozasertib, SNS.314, KW.2449, barasertib, AMG900, AT.9283, GSK1070916, hesperadin, barasertib.HQPA, alisertib, danusertib, MK.8745, CCT137690, CCT129202, ENMD.2076",1.26760624017703,0.39040559077478,FALSE +"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.38406,-1.05,0.378,1249,0.709,"radezolid, tedizolid, josamycin",0.422508200162775,0.149353764816933,FALSE +"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.29783,0.727,0.768,374,1,"novobiocin, finafloxacin, norfloxacin",0.114638779968488,0,FALSE +"H1650","Pearson.est","BCL inhibitor",0.45486,1.11,0.354,432,0.681,"TW.37, gossypol, ABT.737, venetoclax",0.450996737974212,0.166852888087215,FALSE +"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.52214,1.28,0.197,122,0.526,"bafetinib, tozasertib, ponatinib, GZD824",0.705533773838407,0.279014255846261,FALSE +"H1650","Pearson.est","benzodiazepine receptor agonist",0.15989,0.384,0.999,372,0.998,"zaleplon, ZK.93423",0.000434511774017692,0.000869458712628891,FALSE +"H1650","Pearson.est","bromodomain inhibitor",0.53865,1.29,0.165,570,0.558,"bromosporine, I.BET.762, PFI.1, JQ1...., I.BET151",0.782516055786094,0.253365801062421,FALSE +"H1650","Pearson.est","calcium channel blocker",-0.34515,-0.977,0.473,1209,0.8,"SKF.96365, SR.33805, fendiline, efonidipine.monoethanolate",0.325138859262188,0.0969100130080564,FALSE +"H1650","Pearson.est","CC chemokine receptor antagonist",0.65863,1.62,0.0366,338,0.242,"SB.225002, PF.04136309, UNBS.5162, navarixin",1.43651891460559,0.616184634019569,TRUE +"H1650","Pearson.est","CDK inhibitor",0.50274,1.21,0.244,352,0.635,"palbociclib, abemaciclib, indisulam, ribociclib, PHA.848125, dinaciclib, AZD5438, TG.02, alvocidib, P276.00, R547",0.612610173661271,0.197226274708024,FALSE +"H1650","Pearson.est","CHK inhibitor",0.29829,0.742,0.785,753,1,"SB.218078, CHIR.124, AZD7762, PF.477736, LY2606368, SCH.900776",0.105130343254747,0,FALSE +"H1650","Pearson.est","cyclooxygenase inhibitor",-0.19869,-0.551,0.965,1323,0.962,"AM.404, amfenac, FK.3311, tryptanthrin",0.0154726866562074,0.0168249279621871,FALSE +"H1650","Pearson.est","cytochrome P450 inhibitor",0.40667,0.99,0.478,391,0.777,"morin, cobicistat",0.320572103387881,0.109578981199086,FALSE +"H1650","Pearson.est","DNA alkylating agent",0.44459,1.08,0.374,437,0.677,"carmustine, melphalan, carboplatin, cyclophosphamide, TH.302, mitomycin.c, satraplatin",0.42712839779952,0.169411331314856,FALSE +"H1650","Pearson.est","DNA inhibitor",0.55439,1.33,0.141,160,0.595,"mechlorethamine, pibenzimol, carmustine, melphalan, carboplatin, oxaliplatin, bendamustine",0.85078088734462,0.22548303427145,FALSE +"H1650","Pearson.est","DNA methyltransferase inhibitor",0.27051,0.642,0.887,307,1,"disulfiram, fdcyd",0.0520763801682736,0,FALSE +"H1650","Pearson.est","DNA polymerase inhibitor",0.45897,1.12,0.311,326,0.683,"idoxuridine, famciclovir, trifluridine, adefovir.dipivoxil",0.507239610973163,0.165579296318467,FALSE +"H1650","Pearson.est","DNA synthesis inhibitor",0.37837,0.92,0.552,161,0.848,"floxuridine, cyclocytidine, anisomycin",0.258060922270801,0.0716041477432862,FALSE +"H1650","Pearson.est","dopamine receptor antagonist",0.48066,1.16,0.294,328,0.667,"domperidone, amisulpride, paliperidone, sertindole, UH.232...., thioproperazine, isofloxythepin",0.531652669587843,0.175874166083451,FALSE +"H1650","Pearson.est","estrogen receptor agonist",-0.33895,-0.945,0.502,1325,0.809,"estradiol.cypionate, levonorgestrel",0.299296282854981,0.0920514783877277,FALSE +"H1650","Pearson.est","estrogen receptor antagonist",0.44156,1.08,0.354,687,0.677,"toremifene, fulvestrant, danazol, raloxifene",0.450996737974212,0.169411331314856,FALSE +"H1650","Pearson.est","FGFR inhibitor",0.56919,1.38,0.103,98,0.543,"regorafenib, dovitinib, erdafitinib",0.987162775294828,0.265200170411153,FALSE +"H1650","Pearson.est","FLT3 inhibitor",0.60291,1.47,0.0771,377,0.437,"tozasertib, dovitinib, ponatinib, KW.2449, lestaurtinib, TG.101348, TG.02, gilteritinib, sorafenib, pacritinib, ENMD.2076",1.11294562194904,0.359518563029578,FALSE +"H1650","Pearson.est","glucocorticoid receptor agonist",0.19069,0.46,0.987,691,1,"prednisolone, hydrocortisone, triamcinolone, prednisolone.acetate, fluticasone.propionate, difluprednate, rimexolone, methylprednisolone, deflazacort, ciclesonide",0.00568284733036327,0,FALSE +"H1650","Pearson.est","glutamate receptor antagonist",-0.21812,-0.575,0.934,313,0.991,"diazooxonorleucine, felbamate, SIB.1757, kynurenic.acid, CPP, JNJ.16259685, MTPG, ACDPP, IEM1754, latrepirdine, tiletamine, CGP.37849, LY456236",0.0296531237699066,0.00392634551472468,FALSE +"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.47378,1.14,0.302,547,0.663,"CHIR.99021, AZD2858, tideglusib, GSK.3.inhibitor.IX",0.519993057042849,0.178486471595227,FALSE +"H1650","Pearson.est","growth factor receptor inhibitor",0.57335,1.39,0.11,279,0.558,"GSK1838705A, lestaurtinib, PHA.848125, danusertib",0.958607314841775,0.253365801062421,FALSE +"H1650","Pearson.est","HCV inhibitor",0.25381,0.61,0.908,1082,0.999,"mericitabine, embelin, Ro.9187, narlaprevir, daclatasvir, PSI.7976",0.0419141514789149,0.000434511774017692,FALSE +"H1650","Pearson.est","HDAC inhibitor",0.41091,1.01,0.458,413,0.78,"resminostat, panobinostat, M.344, givinostat, PCI.24781, trichostatin.a, R306465, entinostat, nexturastat.a, vorinostat, belinostat, AR.42",0.339134521996131,0.10790539730952,FALSE +"H1650","Pearson.est","histamine receptor antagonist",0.20643,0.501,0.972,16,1,"pheniramine",0.0123337350737254,0,FALSE +"H1650","Pearson.est","HMGCR inhibitor",0.47124,1.15,0.309,239,0.664,"atorvastatin, mevastatin",0.510041520575165,0.177831920631982,FALSE +"H1650","Pearson.est","HSP inhibitor",-0.46995,-1.26,0.203,1208,0.567,"guanidine, XL888, VER.49009, tanespimycin, alvespimycin, KW.2478",0.692503962086787,0.246416941107093,FALSE +"H1650","Pearson.est","JAK inhibitor",0.53189,1.28,0.182,202,0.526,"atiprimod, tozasertib, lestaurtinib, TG.101348, AT.9283, AZ960, TG.02, TG.101209",0.739928612014925,0.279014255846261,FALSE +"H1650","Pearson.est","KIT inhibitor",0.41179,1,0.461,180,0.78,"regorafenib, KI.8751, OSI.930, pazopanib",0.336299074610352,0.10790539730952,FALSE +"H1650","Pearson.est","MDM inhibitor",0.93066,2.25,0,77,0.001,"idasanutlin, nutlin.3, AMG.232, serdemetan, CGM097",Inf,3,TRUE +"H1650","Pearson.est","MEK inhibitor",0.77356,1.86,0.00423,228,0.0789,"cobimetinib, MEK162, AS.703026, AZD8330, selumetinib, PD.0325901, trametinib, Ro.4987655, TAK.733, PD.318088, U.0126, refametinib, PD.198306, PD.184352",2.37365963262496,1.10292299679058,TRUE +"H1650","Pearson.est","MET inhibitor",0.3947,0.95,0.537,538,0.812,"PHA.665752, AMG458, NVP.BVU972, LY2801653",0.270025714300444,0.0904439707588247,FALSE +"H1650","Pearson.est","microtubule inhibitor",0.28584,0.693,0.854,495,1,"vinflunine, vinblastine, D.64131, podophyllotoxin",0.068542129310995,0,FALSE +"H1650","Pearson.est","mTOR inhibitor",-0.32115,-0.883,0.599,1155,0.88,"torin.2, NVP.BEZ235, LY3023414, GSK2126458, PI.103, deforolimus, temsirolimus, everolimus, GDC.0980, PF.05212384, sirolimus",0.222573177610689,0.0555173278498314,FALSE +"H1650","Pearson.est","NFkB pathway inhibitor",0.22361,0.535,0.96,544,1,"bortezomib, curcumin, parthenolide...., BAY.11.7082, parthenolide",0.0177287669604316,0,FALSE +"H1650","Pearson.est","opioid receptor agonist",0.51521,1.25,0.202,329,0.568,"trimebutine, salvinorin.a",0.694648630553376,0.245651664288981,FALSE +"H1650","Pearson.est","p38 MAPK inhibitor",0.58534,1.4,0.116,353,0.578,"skepinone.l, SB.242235",0.935542010773082,0.238072161579471,FALSE +"H1650","Pearson.est","PARP inhibitor",0.48205,1.16,0.311,470,0.667,"talazoparib, niraparib, AG.14361, olaparib, AZD2461",0.507239610973163,0.175874166083451,FALSE +"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.36518,0.886,0.612,180,0.868,"regorafenib, KI.8751, dovitinib, ponatinib, pazopanib",0.213248577854439,0.0614802748235081,FALSE +"H1650","Pearson.est","phosphatase inhibitor",0.53788,1.31,0.173,225,0.575,"GSK2830371, CID.5458317, sodium.stibogluconate, bis.maltolato.oxovanadium.IV.",0.761953896871205,0.24033215531037,FALSE +"H1650","Pearson.est","phosphodiesterase inhibitor",0.35029,0.859,0.624,195,0.876,"anagrelide, GSK256066",0.204815410317576,0.0574958938319193,FALSE +"H1650","Pearson.est","PI3K inhibitor",-0.24215,-0.668,0.898,1176,1,"NVP.BEZ235, LY3023414, GSK2126458, PI.103, TG100.115, CH5132799, GDC.0980, alpelisib, taselisib, PF.05212384",0.0467236633326956,0,FALSE +"H1650","Pearson.est","PLK inhibitor",0.76718,1.84,0.00556,227,0.0719,"rigosertib, volasertib, NMS.1286937, GSK461364",2.25492520841794,1.14327110961712,TRUE +"H1650","Pearson.est","potassium channel blocker",0.26422,0.643,0.879,1067,1,"meglitinide, ML133, mepivacaine, ibutilide, oleoylethanolamide, dofetilide",0.0560111249262281,0,FALSE +"H1650","Pearson.est","PPAR receptor agonist",0.40215,0.981,0.483,524,0.774,"clofibrate, ciprofibrate, GW.501516",0.316052869248488,0.111259039317107,FALSE +"H1650","Pearson.est","progesterone receptor agonist",0.25694,0.617,0.899,701,1,"nomegestrol.acetate, tanaproget, norethindrone, danazol, norethindrone.acetate",0.0462403082667712,0,FALSE +"H1650","Pearson.est","proteasome inhibitor",0.42625,1.03,0.444,402,0.761,"bortezomib, ixazomib, MG.132",0.35261702988538,0.118615343229427,FALSE +"H1650","Pearson.est","protein synthesis inhibitor",0.3727,0.906,0.591,145,0.854,"brefeldin.a, homoharringtonine, cycloheximide",0.228412519118745,0.068542129310995,FALSE +"H1650","Pearson.est","protein tyrosine kinase inhibitor",-0.63167,-1.71,0.0407,1317,0.232,"AV.412, mubritinib, CP.724714, BMS.599626",1.39040559077478,0.6345120151091,TRUE +"H1650","Pearson.est","RAF inhibitor",0.85831,2.06,0,51,0.00752,"dabrafenib, AZ.628, vemurafenib, regorafenib, TAK.632, GDC.0879, SB.590885, LGX818, CEP.32496",Inf,2.12378215940836,TRUE +"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.36771,0.878,0.615,19,0.863,"regorafenib",0.211124884224583,0.0639892042847904,FALSE +"H1650","Pearson.est","retinoid receptor agonist",0.26604,0.651,0.881,609,1,"tamibarotene, adarotene, CD.437, fenretinide, bexarotene",0.0550240915879521,0,FALSE +"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.73194,1.75,0.00823,222,0.127,"cladribine, clofarabine, triapine, LY2334737, fludarabine.phosphate, fludarabine, pentostatin",2.08460016478773,0.896196279044043,TRUE +"H1650","Pearson.est","serotonin receptor agonist",0.29702,0.715,0.827,686,1,"NAN.190, zolmitriptan, SR.57227A, aripiprazole",0.0824944904474534,0,FALSE +"H1650","Pearson.est","serotonin receptor antagonist",0.55486,1.33,0.15,251,0.595,"pirenperone, lerisetron, paliperidone, SB.200646, SB.216641, sertindole",0.823908740944319,0.22548303427145,FALSE +"H1650","Pearson.est","sodium channel blocker",0.19405,0.47,0.989,408,1,"mexiletine, quinidine, ajmaline, benzethonium",0.0048037084028206,0,FALSE +"H1650","Pearson.est","src inhibitor",-0.63439,-1.73,0.0177,1387,0.285,"bosutinib, dasatinib, ZM.306416, saracatinib",1.75202673363819,0.54515513999149,FALSE +"H1650","Pearson.est","sterol demethylase inhibitor",0.29869,0.73,0.802,424,1,"posaconazole, chlormidazole",0.0958256317158365,0,FALSE +"H1650","Pearson.est","TGF beta receptor inhibitor",-0.49787,-1.39,0.135,1054,0.422,"SB.431542, D.4476, LY2109761, repsox",0.869666231504994,0.374687549038326,FALSE +"H1650","Pearson.est","thymidylate synthase inhibitor",0.69187,1.68,0.0161,196,0.187,"carmofur, raltitrexed, trifluridine",1.79317412396815,0.728158393463501,TRUE +"H1650","Pearson.est","topoisomerase inhibitor",0.53856,1.31,0.159,577,0.575,"topotecan, nemorubicin, amsacrine, teniposide, daunorubicin, doxorubicin, voreloxin, etoposide.phosphate, rubitecan, valrubicin, idarubicin, TAS.103, irinotecan, SN.38, fleroxacin, amonafide, exatecan.mesylate, genz.644282",0.798602875679548,0.24033215531037,FALSE +"H1650","Pearson.est","tubulin polymerization inhibitor",0.5329,1.3,0.167,600,0.566,"verubulin, albendazole, fosbretabulin, indibulin, taltobulin, vindesine, BNC105, vinblastine, combretastatin.A.4, oxibendazole, vincristine, parbendazole, vinorelbine, CYT.997, podophyllotoxin, nocodazole, dolastatin.10, KX2.391, ABT.751, plinabulin, fenbendazole",0.777283528852417,0.247183568811729,FALSE +"H1650","Pearson.est","tyrosine kinase inhibitor",-0.2925,-0.797,0.703,1317,0.936,"AV.412, mubritinib, vandetanib, CP.724714, dasatinib, BMS.599626",0.153044674980176,0.0287241512618947,FALSE +"H1650","Pearson.est","VEGFR inhibitor",-0.24596,-0.659,0.874,1307,0.954,"linifanib, MGCD.265, AEE788, vandetanib, ZM.306416, XL.647, BMS.690514",0.058488567365597,0.0204516252959049,FALSE +"H1650","Pearson.est","vitamin D receptor agonist",-0.81696,-2.22,0,1277,0.0199,"paricalcitol, ercalcitriol, calcitriol, tacalcitol, maxacalcitol",Inf,1.70114692359029,TRUE +"HCC95","Pearson.est","EGFR inhibitor",-0.82258,-1.99,0,1339,0.0352,"GW.583340, TAK.285, CNX.2006, CUDC.101, PD.168393, brigatinib, WZ8040, WZ.3146, BMS.599626, AST.1306, icotinib, BIBX.1382, WZ.4002, ARRY.334543, CP.724714, AEE788, rociletinib, BMS.690514, tucatinib, pelitinib, neratinib, lapatinib, AZD8931, osimertinib, dacomitinib, erlotinib, canertinib, XL.647, gefitinib, afatinib, poziotinib",Inf,1.45345733652187,TRUE +"HCC95","Pearson.est","Abl kinase inhibitor",-0.40989,-0.962,0.504,1397,0.833,"bosutinib, ZM.306416",0.297569463554475,0.0793549985932124,FALSE +"HCC95","Pearson.est","acetylcholine receptor agonist",0.39656,1.08,0.348,504,0.512,"nefiracetam, tremorine, oxiracetam, nicotine, pilocarpine",0.458420756053419,0.290730039024169,FALSE +"HCC95","Pearson.est","acetylcholine receptor antagonist",0.4861,1.34,0.168,15,0.341,"iododexetimide",0.774690718274137,0.467245621007502,FALSE +"HCC95","Pearson.est","adenosine receptor antagonist",-0.55151,-1.3,0.172,1441,0.491,"CGS.15943",0.764471553092451,0.308918507877032,FALSE +"HCC95","Pearson.est","adrenergic receptor agonist",0.33077,0.905,0.518,974,0.716,"ritodrine, isoxsuprine, isoetharine, xylazine, norepinephrine, epinephrine, oxymetazoline, metaraminol, methyldopa, terbutaline, buphenine, lidamidine, midodrine, A61603, clenbuterol",0.285670240254767,0.145086977692144,FALSE +"HCC95","Pearson.est","adrenergic receptor antagonist",-0.28586,-0.702,0.82,807,0.993,"atenolol......, prazosin, idazoxan, dronedarone, practolol, dihydroergocristine, carvedilol, RS.17053, vincamine, imiloxan",0.0861861476162833,0.00305075150461883,FALSE +"HCC95","Pearson.est","AKT inhibitor",-0.60449,-1.45,0.0873,1313,0.425,"CCT128930, GDC.0068, triciribine, uprosertib",1.05898575629443,0.371611069949688,FALSE +"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.6994,-1.64,0.0242,1232,0.281,"NVP.TAE684, CEP.37440, alectinib, SB.505124, brigatinib, AZD3463",1.61618463401957,0.55129368009492,FALSE +"HCC95","Pearson.est","androgen receptor antagonist",0.64869,1.75,0.0534,368,0.192,"bicalutamide, enzalutamide, flutamide",1.27245874297144,0.71669877129645,FALSE +"HCC95","Pearson.est","antioxidant",0.64578,1.77,0.0208,117,0.22,"benfotiamine, trolox, chlorogenic.acid",1.68193666503724,0.657577319177794,TRUE +"HCC95","Pearson.est","AP inhibitor",0.45306,1.25,0.238,313,0.365,"idronoxil, birinapant, GDC.0152",0.623423042943488,0.437707135543525,FALSE +"HCC95","Pearson.est","ATPase inhibitor",-0.47937,-1.13,0.32,1039,0.637,"digoxin, digitoxigenin, evodiamine, oligomycin.a, rabeprazole, NMS.873, k.strophanthidin",0.494850021680094,0.19586056766465,FALSE +"HCC95","Pearson.est","Aurora kinase inhibitor",-0.65237,-1.56,0.0538,961,0.308,"AMG900, SNS.314, AT.9283, barasertib, aurora.a.inhibitor.i, CCT137690, PF.03814735, MK.5108, GSK1070916, alisertib, ENMD.2076, hesperadin, MK.8745, MLN.8054, ZM.447439, CCT129202, TAK.901, barasertib.HQPA, danusertib, CYC116, PHA.680632",1.26921772433361,0.511449283499556,FALSE +"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.63074,-1.51,0.0637,1146,0.374,"valnemulin, tedizolid, azithromycin, radezolid",1.19586056766465,0.42712839779952,FALSE +"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.54674,1.5,0.108,135,0.258,"nadifloxacin, sparfloxacin, novobiocin",0.96657624451305,0.58838029403677,FALSE +"HCC95","Pearson.est","BCL inhibitor",0.57806,1.58,0.062,274,0.278,"oridonin, ABT.737, venetoclax, navitoclax",1.20760831050175,0.555955204081924,FALSE +"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.2711,-0.645,0.881,1227,1,"metatinib, bosutinib",0.0550240915879521,0,FALSE +"HCC95","Pearson.est","benzodiazepine receptor agonist",-0.21704,-0.519,0.967,1058,1,"ZK.93423, bentazepam, ivermectin",0.0145735259169983,0,FALSE +"HCC95","Pearson.est","bromodomain inhibitor",-0.51158,-1.23,0.223,1037,0.533,"I.BET151, JQ1...., OTX015, I.BET.762",0.651695136951839,0.273272790973428,FALSE +"HCC95","Pearson.est","calcium channel blocker",-0.43596,-1.03,0.413,840,0.723,"mibefradil, fendiline, tetrandrine, carboxyamidotriazole, efonidipine.monoethanolate, penfluridol",0.384049948343599,0.140861702705469,FALSE +"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.25263,-0.594,0.937,980,1,"MK.0812, SB.225002, ZK811752",0.0282604091122217,0,FALSE +"HCC95","Pearson.est","CDK inhibitor",-0.59551,-1.42,0.115,1022,0.417,"dinaciclib, ribociclib, palbociclib, PHA.848125, alvocidib, TG.02, R547, aminopurvalanol.a, arcyriaflavin.a, indisulam, JNJ.7706621, BMS.265246, PHA.793887, AT.7519, BMS.387032",0.939302159646388,0.379863945026242,FALSE +"HCC95","Pearson.est","CHK inhibitor",-0.38498,-0.924,0.561,1088,0.857,"LY2603618, SB.218078",0.251037138743839,0.0670191780768018,FALSE +"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.2133,-0.518,0.976,839,1,"curcumin, indoprofen, phenazone, aspirin, piroxicam, FK.3311, FR.122047, ramifenazone, amfenac, tryptanthrin",0.0105501823333082,0,FALSE +"HCC95","Pearson.est","cytochrome P450 inhibitor",0.57248,1.54,0.0797,206,0.282,"metyrapone, clotrimazole, morin",1.09854167860389,0.549750891680639,FALSE +"HCC95","Pearson.est","DNA alkylating agent",-0.29434,-0.708,0.815,1073,1,"cyclophosphamide, mitomycin.c, estramustine, dacarbazine",0.0888423912600234,0,FALSE +"HCC95","Pearson.est","DNA inhibitor",0.3543,0.936,0.511,193,0.73,"nimorazole, carboplatin, pibenzimol, bendamustine, metronidazole, nithiamide",0.291579099865287,0.136677139879544,FALSE +"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.66795,-1.59,0.0352,1132,0.288,"fdcyd, SGI.1027, azacitidine, decitabine",1.45345733652187,0.540607512240769,FALSE +"HCC95","Pearson.est","DNA polymerase inhibitor",-0.30702,-0.742,0.8,918,1,"idoxuridine, trifluridine, cidofovir, cephalomannine",0.0969100130080564,0,FALSE +"HCC95","Pearson.est","DNA synthesis inhibitor",-0.39352,-0.951,0.528,1191,0.829,"mitomycin.c, cyclocytidine, anisomycin, enocitabine",0.277366077466188,0.0814454694497265,FALSE +"HCC95","Pearson.est","dopamine receptor antagonist",0.20647,0.564,0.959,125,0.989,"amisulpride, clebopride, ziprasidone",0.0181813928293364,0.0048037084028206,FALSE +"HCC95","Pearson.est","estrogen receptor agonist",-0.3294,-0.769,0.744,1351,1,"levonorgestrel",0.128427064454121,0,FALSE +"HCC95","Pearson.est","estrogen receptor antagonist",0.49537,1.4,0.0819,47,0.302,"danazol, toremifene",1.08671609823958,0.519993057042849,FALSE +"HCC95","Pearson.est","FGFR inhibitor",0.3212,0.848,0.576,250,0.75,"erdafitinib, orantinib, dovitinib",0.239577516576788,0.1249387366083,FALSE +"HCC95","Pearson.est","FLT3 inhibitor",-0.15575,-0.367,0.999,1100,0.999,"TG.02, ENMD.2076, pacritinib",0.000434511774017692,0.000434511774017692,FALSE +"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.52912,-1.25,0.212,1030,0.517,"betamethasone, rimexolone, desonide, methylprednisolone, difluprednate, deflazacort, beclomethasone.dipropionate, halcinonide, clobetasol.propionate, flumethasone.pivalate, triamcinolone.acetonide, halobetasol.propionate, fluorometholone, flumethasone, ciclesonide",0.673664139071249,0.286509456906058,FALSE +"HCC95","Pearson.est","glutamate receptor antagonist",-0.15638,-0.372,0.999,893,1,"CPP, SIB.1757, CGP.37849, LY456236",0.000434511774017692,0,FALSE +"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.70409,1.91,0.0148,167,0.141,"CHIR.98014, CHIR.99021, GSK.3.inhibitor.IX, tideglusib, LY2090314",1.82973828460504,0.85078088734462,TRUE +"HCC95","Pearson.est","growth factor receptor inhibitor",-0.57559,-1.35,0.145,863,0.469,"lestaurtinib, GSK1904529A, PHA.848125, GSK1838705A, danusertib, AZD3463",0.838631997765025,0.328827157284917,FALSE +"HCC95","Pearson.est","HCV inhibitor",-0.30609,-0.734,0.783,994,1,"PSI.7976, narlaprevir",0.106238237942057,0,FALSE +"HCC95","Pearson.est","HDAC inhibitor",-0.35522,-0.84,0.659,793,0.993,"resminostat, romidepsin, R306465, chidamide, RGFP966, M.344, ACY.1215, belinostat, NSC.3852, trichostatin.a, AR.42, scriptaid, vorinostat, givinostat, PCI.24781, JNJ.26481585, SB.939, dacinostat",0.18111458540599,0.00305075150461883,FALSE +"HCC95","Pearson.est","histamine receptor antagonist",0.14755,0.409,1,1237,0.999,"epinastine, lafutidine, chloropyramine, famotidine, nizatidine, ICI.162846, cimetidine, tecastemizole, cyproheptadine, astemizole, pheniramine, ranitidine, tiotidine, BF2.649, zolantidine, terfenadine, levocetirizine, ebastine",0,0.000434511774017692,FALSE +"HCC95","Pearson.est","HMGCR inhibitor",0.92748,2.54,0,10,0.00125,"pitavastatin, fluvastatin, lovastatin, mevastatin, atorvastatin",Inf,2.90308998699194,TRUE +"HCC95","Pearson.est","HSP inhibitor",-0.55835,-1.31,0.164,1012,0.499,"ganetespib, VER.49009, alvespimycin, NVP.AUY922, KW.2478, BIIB021, PU.H71, tanespimycin",0.785156151952302,0.30189945437661,FALSE +"HCC95","Pearson.est","JAK inhibitor",-0.54278,-1.28,0.206,863,0.507,"lestaurtinib, CEP.33779, ruxolitinib, AT.9283, baricitinib, LY2784544, TG.02, AZD1480, WHI.P154, AZ960, PRT062070, pacritinib, filgotinib",0.686132779630847,0.294992040666664,FALSE +"HCC95","Pearson.est","KIT inhibitor",-0.15802,-0.38,0.999,876,1,"lenvatinib, imatinib, cediranib, vatalanib, OSI.930",0.000434511774017692,0,FALSE +"HCC95","Pearson.est","MDM inhibitor",0.81246,2.28,0,98,0.00939,"AMG.232, idasanutlin, CGM097, nutlin.3",Inf,2.02733440773389,TRUE +"HCC95","Pearson.est","MEK inhibitor",0.27506,0.761,0.734,290,0.864,"BIX.02188, U.0126, refametinib, cobimetinib, MEK1.2.inhibitor",0.134303940083929,0.0634862575211067,FALSE +"HCC95","Pearson.est","MET inhibitor",0.61519,1.69,0.0563,187,0.212,"NVP.BVU972, AMG458, PHA.665752",1.24949160514865,0.673664139071249,FALSE +"HCC95","Pearson.est","microtubule inhibitor",-0.59401,-1.42,0.0886,1168,0.417,"colchicine, podophyllotoxin, vinflunine, cabazitaxel, D.64131",1.05256627811295,0.379863945026242,FALSE +"HCC95","Pearson.est","mTOR inhibitor",-0.4901,-1.17,0.279,1057,0.632,"AZD2014, torin.2, deforolimus, MLN0128, torin.1, PP242, WYE.125132, PI.103, AZD8055, GDC.0980, GSK2126458, WYE.354, PF.05212384",0.554395796726402,0.199282921717615,FALSE +"HCC95","Pearson.est","NFkB pathway inhibitor",-0.29437,-0.682,0.838,839,0.997,"curcumin, parthenolide...., IKK.2.inhibitor.V, parthenolide, Ro.106.9920, EVP4593",0.0767559813697235,0.00130484168834428,FALSE +"HCC95","Pearson.est","opioid receptor agonist",0.48571,1.33,0.135,121,0.328,"BW.180C, ADL5859",0.869666231504994,0.484126156288321,FALSE +"HCC95","Pearson.est","p38 MAPK inhibitor",-0.59319,-1.41,0.104,1237,0.406,"CMPD.1, SB.239063, talmapimod",0.98296666070122,0.391473966422806,FALSE +"HCC95","Pearson.est","PARP inhibitor",-0.30692,-0.732,0.792,809,0.998,"endo.IWR.1, olaparib, AZD2461, PJ.34, niraparib, talazoparib",0.101274818410506,0.000869458712628891,FALSE +"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.25136,0.686,0.871,474,0.939,"orantinib, KI.8751, ponatinib, linifanib, dovitinib, pazopanib, telatinib, trapidil, regorafenib, tandutinib, nintedanib, masitinib, CP.673451",0.0599818449923368,0.0273344077338891,FALSE +"HCC95","Pearson.est","phosphatase inhibitor",0.46615,1.29,0.192,236,0.344,"bis.maltolato.oxovanadium.IV., BVT.948, GSK2830371, menadione, CID.5458317",0.71669877129645,0.46344155742847,FALSE +"HCC95","Pearson.est","phosphodiesterase inhibitor",0.40609,1.08,0.325,79,0.512,"anagrelide, enoximone, GSK256066",0.488116639021126,0.290730039024169,FALSE +"HCC95","Pearson.est","PI3K inhibitor",-0.47691,-1.13,0.341,1184,0.637,"PI.103, PIK.75, TG.100713, GDC.0980, CH5132799, GSK2126458, PF.05212384, alpelisib, taselisib",0.467245621007502,0.19586056766465,FALSE +"HCC95","Pearson.est","PLK inhibitor",-0.78624,-1.89,0.00418,1195,0.079,"rigosertib, HMN.214, GW.843682X, BI.2536, volasertib, NMS.1286937",2.37882371822496,1.10237290870956,TRUE +"HCC95","Pearson.est","potassium channel blocker",0.34357,0.927,0.561,231,0.711,"meglitinide, ML133",0.251037138743839,0.148130399270234,FALSE +"HCC95","Pearson.est","PPAR receptor agonist",0.51159,1.43,0.101,124,0.298,"fenofibrate, clofibrate, S26948",0.995678626217357,0.525783735923745,FALSE +"HCC95","Pearson.est","progesterone receptor agonist",0.55773,1.53,0.0931,166,0.259,"norethindrone, danazol, nomegestrol.acetate, norethindrone.acetate, norgestrel",1.03105031901866,0.586700235918748,FALSE +"HCC95","Pearson.est","proteasome inhibitor",-0.46498,-1.1,0.348,1201,0.649,"carfilzomib",0.458420756053419,0.187755303199631,FALSE +"HCC95","Pearson.est","protein synthesis inhibitor",-0.52955,-1.25,0.22,1054,0.517,"chloramphenicol.palmitate, emetine, thiostrepton, anguidine, cycloheximide, harringtonine, puromycin, homoharringtonine, tedizolid.phosphate, bruceantin",0.657577319177794,0.286509456906058,FALSE +"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.73593,-1.77,0.0111,1400,0.124,"BMS.599626, NVP.TAE226, CP.724714, AV.412",1.95467702121334,0.906578314837765,TRUE +"HCC95","Pearson.est","RAF inhibitor",0.43855,1.22,0.234,58,0.376,"dabrafenib, vemurafenib",0.630784142589857,0.424812155072339,FALSE +"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.4612,-1.1,0.351,1049,0.649,"cabozantinib, vandetanib",0.454692883534176,0.187755303199631,FALSE +"HCC95","Pearson.est","retinoid receptor agonist",-0.34089,-0.823,0.678,898,0.998,"bexarotene, adapalene, tamibarotene, adarotene, CD.437",0.168770306132937,0.000869458712628891,FALSE +"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.33818,0.9,0.54,211,0.693,"pentostatin, hydroxyurea, fludarabine",0.267606240177031,0.159266765388193,FALSE +"HCC95","Pearson.est","serotonin receptor agonist",-0.62769,-1.47,0.0785,1229,0.417,"zolmitriptan, pardoprunox, aripiprazole",1.10513034325475,0.379863945026242,FALSE +"HCC95","Pearson.est","serotonin receptor antagonist",-0.31242,-0.742,0.788,1061,1,"sertindole, RS.16566, SB.228357, aripiprazole",0.103473782510445,0,FALSE +"HCC95","Pearson.est","sodium channel blocker",-0.23778,-0.562,0.942,1094,1,"lappaconite, benzethonium, A.803467, brivaracetam",0.0259490972071227,0,FALSE +"HCC95","Pearson.est","src inhibitor",-0.76153,-1.82,0.00821,1397,0.107,"bosutinib, saracatinib, ZM.306416",2.08565684288056,0.97061622231479,TRUE +"HCC95","Pearson.est","sterol demethylase inhibitor",0.23786,0.665,0.885,1105,0.931,"posaconazole, terconazole, chlormidazole, ketoconazole, sulconazole, lanoconazole",0.0530567293021746,0.0310503190186574,FALSE +"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.55703,-1.31,0.166,960,0.499,"SB.525334, adaprev, D.4476, repsox",0.779891911959945,0.30189945437661,FALSE +"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.32746,-0.787,0.711,1338,1,"carmofur",0.148130399270234,0,FALSE +"HCC95","Pearson.est","topoisomerase inhibitor",-0.43831,-1.05,0.41,816,0.729,"valrubicin, licochalcone.a, teniposide, daunorubicin, etoposide, beta.lapachone, idarubicin, irinotecan, amsacrine, TAS.103, mitoxantrone, genz.644282, amonafide, camptothecin, SN.38, exatecan.mesylate, dexrazoxane",0.387216143280265,0.137272471682025,FALSE +"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.67484,-1.62,0.0288,1121,0.272,"combretastatin.A.4, flubendazole, podophyllotoxin, CYT.997, indibulin, mebendazole, vincristine, fenbendazole, taltobulin, albendazole, dolastatin.10, plinabulin, fosbretabulin, nocodazole, ABT.751, vinorelbine, epothilone.b, parbendazole, paclitaxel, docetaxel",1.54060751224077,0.565431095965801,FALSE +"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.48879,-1.14,0.318,1314,0.667,"vandetanib, BMS.599626, NVP.TAE226, CP.724714, AV.412, tivantinib",0.497572880015567,0.175874166083451,FALSE +"HCC95","Pearson.est","VEGFR inhibitor",-0.44053,-1.03,0.43,1010,0.723,"golvatinib, semaxanib, cabozantinib, cediranib, SU014813, vatalanib, PD.173074, ENMD.2076, lucitanib, OSI.930, vandetanib, AEE788, ZM.306416, BMS.690514, XL.647",0.366531544420413,0.140861702705469,FALSE +"HCC95","Pearson.est","vitamin D receptor agonist",-0.5881,-1.4,0.112,913,0.398,"doxercalciferol, calcitriol, ercalcitriol, paricalcitol, tacalcitol, maxacalcitol",0.950781977329818,0.400116927926312,FALSE +"H1975","Pearson.est","EGFR inhibitor",0.70857,1.73,0.00972,249,0.295,"neratinib, AZD8931, AST.1306, gefitinib, poziotinib, erlotinib, afatinib, tucatinib, dacomitinib, CUDC.101, lapatinib, pelitinib, XL.647, BIBU.1361, BMS.690514, ARRY.334543, osimertinib, dovitinib, BIBX.1382, canertinib, AEE788, WZ.4002, CNX.2006, CP.724714, WZ.3146, vandetanib",2.01233373507373,0.530177984021837,FALSE +"H1975","Pearson.est","Abl kinase inhibitor",0.48988,1.22,0.242,98,0.597,"ZM.306416, bafetinib",0.616184634019569,0.224025668870631,FALSE +"H1975","Pearson.est","acetylcholine receptor agonist",0.36708,0.913,0.573,505,0.725,"xanomeline, pilocarpine, tremorine, oxiracetam",0.24184537803261,0.139661993429006,FALSE +"H1975","Pearson.est","acetylcholine receptor antagonist",-0.63911,-1.78,0.0257,1277,0.163,"methscopolamine, iododexetimide",1.59006687666871,0.787812395596042,TRUE +"H1975","Pearson.est","adenosine receptor antagonist",0.44599,1.1,0.345,444,0.613,"CGS.15943, MRS.1220, istradefylline, sulmazole, PSB.1115, SCH.58261",0.462180904926726,0.212539525481585,FALSE +"H1975","Pearson.est","adrenergic receptor agonist",-0.56444,-1.54,0.0838,1086,0.275,"ritodrine, buphenine, epinephrine, A61603, clenbuterol, norepinephrine, isoxsuprine, midodrine, lidamidine, xylazine",1.07675598136972,0.560667306169737,FALSE +"H1975","Pearson.est","adrenergic receptor antagonist",0.28701,0.715,0.804,42,0.9,"atenolol......, dihydroergocristine",0.0947439512515487,0.0457574905606751,FALSE +"H1975","Pearson.est","AKT inhibitor",0.41933,1.03,0.406,445,0.646,"uprosertib, GDC.0068, GSK2110183, A.674563, triciribine, palomid.529",0.391473966422806,0.189767482004916,FALSE +"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.46751,1.16,0.27,518,0.598,"alectinib, CEP.37440, NVP.TAE684, crizotinib, DMH1, brigatinib, SB.505124, AZD3463",0.568636235841013,0.223298816011589,FALSE +"H1975","Pearson.est","androgen receptor antagonist",-0.43961,-1.18,0.272,940,0.476,"RU.58841, bicalutamide, cyproterone.acetate, flutamide, enzalutamide",0.565431095965801,0.322393047279507,FALSE +"H1975","Pearson.est","antioxidant",-0.58277,-1.55,0.0962,1076,0.294,"benfotiamine, chlorogenic.acid, taurine, rutin",1.01682492796219,0.531652669587843,FALSE +"H1975","Pearson.est","AP inhibitor",-0.91447,-2.44,0,1431,0,"LCL.161, GDC.0152, birinapant",Inf,Inf,TRUE +"H1975","Pearson.est","ATPase inhibitor",-0.44021,-1.19,0.243,1216,0.514,"omeprazole, digitoxin, blebbistatin...., digitoxigenin, ouabain",0.614393726401688,0.289036881004724,FALSE +"H1975","Pearson.est","Aurora kinase inhibitor",0.3713,0.916,0.549,276,0.74,"ENMD.2076, CCT137690, PHA.680632, danusertib, barasertib.HQPA, hesperadin",0.260427655549908,0.130768280269024,FALSE +"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.28974,-0.776,0.739,1157,0.863,"tedizolid, josamycin, dirithromycin",0.131355561605174,0.0639892042847904,FALSE +"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.46848,-1.27,0.193,1340,0.492,"sarafloxacin, sparfloxacin",0.714442690992226,0.30803489723264,FALSE +"H1975","Pearson.est","BCL inhibitor",0.48751,1.21,0.25,219,0.585,"TW.37, obatoclax, gossypol",0.602059991327962,0.23284413391782,FALSE +"H1975","Pearson.est","Bcr.Abl kinase inhibitor",0.32739,0.814,0.679,98,0.824,"bafetinib",0.168130225719498,0.0840727883028842,FALSE +"H1975","Pearson.est","benzodiazepine receptor agonist",-0.27776,-0.718,0.804,1217,0.869,"nefiracetam, lorazepam, indiplon, CGS.20625",0.0947439512515487,0.0609802235513335,FALSE +"H1975","Pearson.est","bromodomain inhibitor",0.76144,1.88,0.0031,350,0.125,"I.BET151, JQ1...., bromosporine, OTX015, I.BET.762, PFI.1",2.50863830616573,0.903089986991944,TRUE +"H1975","Pearson.est","calcium channel blocker",0.34357,0.859,0.633,335,0.775,"tetrandrine, cinnarazine, mibefradil",0.198596289982645,0.11069829749369,FALSE +"H1975","Pearson.est","CC chemokine receptor antagonist",0.38259,0.954,0.511,462,0.695,"ZK811752, UNBS.5162, SB.225002",0.291579099865287,0.158015195409886,FALSE +"H1975","Pearson.est","CDK inhibitor",0.4781,1.17,0.281,442,0.605,"TG.02, R547, P276.00, indisulam, indirubin, ribociclib, arcyriaflavin.a, abemaciclib, PHA.848125, NU6027, JNJ.7706621",0.55129368009492,0.218244625347531,FALSE +"H1975","Pearson.est","CHK inhibitor",0.59221,1.47,0.0837,384,0.514,"AZD7762, PF.477736, SB.218078, CHIR.124",1.07727454200674,0.289036881004724,FALSE +"H1975","Pearson.est","cyclooxygenase inhibitor",-0.29134,-0.776,0.71,1178,0.863,"AM.404, phenylbutazone, indoprofen, amfenac, acetylsalicylsalicylic.acid, suxibuzone, metoxibutropate",0.148741651280925,0.0639892042847904,FALSE +"H1975","Pearson.est","cytochrome P450 inhibitor",-0.64187,-1.77,0.0279,1118,0.15,"morin, eplerenone, clotrimazole",1.5543957967264,0.823908740944319,TRUE +"H1975","Pearson.est","DNA alkylating agent",-0.2485,-0.675,0.851,1235,0.873,"carboplatin, streptozotocin, cisplatin",0.0700704399154121,0.0589857562944303,FALSE +"H1975","Pearson.est","DNA inhibitor",0.39292,0.967,0.502,488,0.692,"mechlorethamine, bendamustine, valrubicin, oxaliplatin, nimorazole, nithiamide, melphalan",0.299296282854981,0.159893905543242,FALSE +"H1975","Pearson.est","DNA methyltransferase inhibitor",0.57599,1.46,0.109,267,0.478,"fdcyd, disulfiram, azacitidine",0.962573502059376,0.320572103387881,FALSE +"H1975","Pearson.est","DNA polymerase inhibitor",-0.30178,-0.807,0.642,1319,0.872,"foscarnet, cephalomannine",0.192464971931147,0.0594835150674328,FALSE +"H1975","Pearson.est","DNA synthesis inhibitor",-0.34883,-0.954,0.466,1432,0.729,"cisplatin, altretamine",0.33161408331,0.137272471682025,FALSE +"H1975","Pearson.est","dopamine receptor antagonist",0.28061,0.705,0.82,164,0.836,"mesoridazine, sertindole, domperidone",0.0861861476162833,0.0777937225609836,FALSE +"H1975","Pearson.est","estrogen receptor agonist",-0.275,-0.747,0.759,1242,0.882,"estradiol.cypionate, estradiol",0.11975822410452,0.0545314148681803,FALSE +"H1975","Pearson.est","estrogen receptor antagonist",0.44179,1.11,0.342,45,0.642,"clomifene",0.465973893943865,0.192464971931147,FALSE +"H1975","Pearson.est","FGFR inhibitor",0.50863,1.28,0.192,112,0.506,"regorafenib, dovitinib",0.71669877129645,0.295849483160201,FALSE +"H1975","Pearson.est","FLT3 inhibitor",0.55149,1.38,0.136,236,0.477,"pacritinib, TG.02, ENMD.2076, dovitinib, sorafenib, TG.101348",0.866461091629782,0.321481620959886,FALSE +"H1975","Pearson.est","glucocorticoid receptor agonist",0.65972,1.63,0.0382,297,0.342,"hydrocortisone, ciclesonide, difluprednate, triamcinolone.acetonide, desonide, rimexolone, methylprednisolone, deflazacort, halobetasol.propionate, halcinonide, triamcinolone, fludroxycortide, beclomethasone.dipropionate, prednisolone.acetate, clobetasol.propionate, prednisolone, flumethasone.pivalate",1.41793663708829,0.465973893943865,FALSE +"H1975","Pearson.est","glutamate receptor antagonist",0.28824,0.709,0.807,111,0.849,"CPP, CGP.37849",0.0931264652779296,0.0710923097560473,FALSE +"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.41589,-1.1,0.325,1334,0.542,"tideglusib, CHIR.98014",0.488116639021126,0.266000713461613,FALSE +"H1975","Pearson.est","growth factor receptor inhibitor",0.48444,1.19,0.232,518,0.596,"danusertib, GSK1838705A, PHA.848125, lestaurtinib, AZD3463",0.6345120151091,0.224753740259764,FALSE +"H1975","Pearson.est","HCV inhibitor",-0.42954,-1.16,0.279,932,0.478,"mericitabine, daclatasvir, narlaprevir, PSI.7976",0.554395796726402,0.320572103387881,FALSE +"H1975","Pearson.est","HDAC inhibitor",0.55686,1.38,0.116,394,0.477,"PCI.24781, M.344, givinostat, scriptaid, vorinostat, R306465, trichostatin.a, NSC.3852, RGFP966, AR.42, SB.939, resminostat, dacinostat, ACY.1215, belinostat, nexturastat.a",0.935542010773082,0.321481620959886,FALSE +"H1975","Pearson.est","histamine receptor antagonist",-0.469,-1.28,0.187,1264,0.512,"nizatidine, ebastine, lafutidine, zolantidine, tiotidine, cimetidine, chloropyramine",0.728158393463501,0.290730039024169,FALSE +"H1975","Pearson.est","HMGCR inhibitor",-0.80608,-2.1,0.00565,1397,0.0581,"pitavastatin, mevastatin, fluvastatin",2.24795155218056,1.23582386760967,TRUE +"H1975","Pearson.est","HSP inhibitor",-0.6217,-1.71,0.0488,1022,0.176,"XL888, VER.49009, guanidine, ganetespib, KW.2478, BIIB021, NVP.AUY922, PU.H71, alvespimycin",1.31158017799729,0.75448733218585,TRUE +"H1975","Pearson.est","JAK inhibitor",0.44456,1.11,0.336,41,0.642,"atiprimod, pacritinib, TG.02, AZ960",0.473660722610156,0.192464971931147,FALSE +"H1975","Pearson.est","KIT inhibitor",0.34818,0.864,0.625,61,0.787,"OSI.930, regorafenib",0.204119982655925,0.104025267640935,FALSE +"H1975","Pearson.est","MDM inhibitor",0.81415,2.02,0.00152,274,0.0524,"idasanutlin, nutlin.3, RITA, CGM097, AMG.232, serdemetan",2.81815641205523,1.28066871301627,TRUE +"H1975","Pearson.est","MEK inhibitor",0.4434,1.09,0.353,508,0.607,"cobimetinib, AS.703026, trametinib, PD.0325901, selumetinib, MEK162, AZD8330, MEK1.2.inhibitor, Ro.4987655, PD.198306, TAK.733, U.0126",0.452225294612177,0.216811308924742,FALSE +"H1975","Pearson.est","MET inhibitor",-0.72939,-2.01,0.0139,1404,0.0851,"PF.04217903, LY2801653",1.8569851997459,1.07007043991541,TRUE +"H1975","Pearson.est","microtubule inhibitor",-0.6915,-1.89,0.0131,1328,0.111,"cabazitaxel, vinblastine, cytochalasin.b",1.88272870434424,0.954677021213343,TRUE +"H1975","Pearson.est","mTOR inhibitor",0.52818,1.31,0.167,454,0.545,"GSK2126458, WAY.600, WYE.125132, voxtalisib, XL388, PP242, AZD8055, torin.2, AZD2014, GDC.0980, OSI.027, PF.04691502, WYE.354, LY303511, palomid.529, PKI.179",0.777283528852417,0.263603497723358,FALSE +"H1975","Pearson.est","NFkB pathway inhibitor",0.16239,0.408,0.997,264,0.997,"EVP4593, curcumin",0.00130484168834428,0.00130484168834428,FALSE +"H1975","Pearson.est","opioid receptor agonist",-0.56681,-1.53,0.0769,1270,0.258,"ADL5859, BW.180C, spiradoline",1.11407366019857,0.58838029403677,FALSE +"H1975","Pearson.est","p38 MAPK inhibitor",0.57292,1.42,0.126,328,0.476,"SB.242235, talmapimod, skepinone.l, CMPD.1",0.899629454882437,0.322393047279507,FALSE +"H1975","Pearson.est","PARP inhibitor",-0.28559,-0.744,0.718,1266,0.859,"olaparib, E7449",0.1438755557577,0.0660068361687577,FALSE +"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30189,-0.814,0.649,1387,0.892,"linifanib, SU014813, CP.673451",0.187755303199631,0.0496351456238769,FALSE +"H1975","Pearson.est","phosphatase inhibitor",0.41646,1.02,0.441,330,0.642,"mycophenolate.mofetil, alexidine, mycophenolic.acid, CID.5458317",0.355561410532161,0.192464971931147,FALSE +"H1975","Pearson.est","phosphodiesterase inhibitor",-0.31464,-0.858,0.62,1148,0.842,"EMD.53998, zardaverine, GSK256066, YM.976",0.207608310501746,0.0746879085003505,FALSE +"H1975","Pearson.est","PI3K inhibitor",0.52651,1.31,0.169,454,0.545,"GSK2126458, taselisib, YM.201636, PI3K.IN.2, alpelisib, GDC.0941, voxtalisib, CUDC.907, CH5132799, buparlisib, PI.828, GDC.0980, BGT226, PF.04691502, PIK.75, pilaralisib, LY303511, PKI.179",0.772113295386326,0.263603497723358,FALSE +"H1975","Pearson.est","PLK inhibitor",0.28684,0.711,0.813,208,0.865,"NMS.1286937",0.0899094544059319,0.0629838925351858,FALSE +"H1975","Pearson.est","potassium channel blocker",-0.45178,-1.22,0.248,1138,0.501,"meglitinide, mepivacaine, dofetilide",0.605548319173784,0.300162274132754,FALSE +"H1975","Pearson.est","PPAR receptor agonist",-0.51554,-1.38,0.158,1282,0.406,"clofibrate, S26948, fenofibrate",0.801342913045577,0.391473966422806,FALSE +"H1975","Pearson.est","progesterone receptor agonist",-0.43137,-1.18,0.236,1349,0.476,"norgestrel, dienogest",0.627087997029893,0.322393047279507,FALSE +"H1975","Pearson.est","proteasome inhibitor",-0.44693,-1.22,0.239,1312,0.501,"ONX.0914, delanzomib",0.621602099051862,0.300162274132754,FALSE +"H1975","Pearson.est","protein synthesis inhibitor",0.4036,0.998,0.456,441,0.66,"azomycin..2.nitroimidazole., brefeldin.a, cycloheximide, clindamycin.phosphate, homoharringtonine, anguidine, bruceantin, thiostrepton, clofoctol",0.341035157335565,0.180456064458131,FALSE +"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.58408,1.45,0.0787,316,0.453,"NVP.TAE226, tyrphostin.A9, CP.724714, AV.412, BMS.599626",1.10402526764094,0.343901797987168,FALSE +"H1975","Pearson.est","RAF inhibitor",0.66789,1.67,0.0321,338,0.335,"SB.590885, regorafenib, AZ.628, CEP.32496, sorafenib, TAK.632, LGX818, dabrafenib",1.49349496759513,0.474955192963155,FALSE +"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.62506,1.55,0.0641,249,0.454,"regorafenib, sorafenib, vandetanib",1.19314197048118,0.342944147142896,FALSE +"H1975","Pearson.est","retinoid receptor agonist",0.5109,1.28,0.186,346,0.506,"CD.437, fenretinide, tamibarotene, adarotene, bexarotene",0.730487055782084,0.295849483160201,FALSE +"H1975","Pearson.est","ribonucleotide reductase inhibitor",0.4279,1.08,0.365,269,0.603,"cytarabine, fludarabine.phosphate, pentostatin",0.437707135543525,0.219682687859849,FALSE +"H1975","Pearson.est","serotonin receptor agonist",-0.74427,-1.98,0.00289,1272,0.0784,"SR.57227A, pardoprunox, ipsapirone, aripiprazole",2.53910215724345,1.10568393731556,TRUE +"H1975","Pearson.est","serotonin receptor antagonist",-0.35201,-0.943,0.475,1447,0.718,"aripiprazole",0.323306390375133,0.1438755557577,FALSE +"H1975","Pearson.est","sodium channel blocker",-0.25186,-0.687,0.859,1141,0.884,"lappaconite, mepivacaine, brivaracetam, cibenzoline",0.0660068361687577,0.0535477349869269,FALSE +"H1975","Pearson.est","src inhibitor",0.32452,0.812,0.711,96,0.807,"ZM.306416",0.148130399270234,0.0931264652779296,FALSE +"H1975","Pearson.est","sterol demethylase inhibitor",0.30121,0.739,0.777,591,0.891,"posaconazole, lanoconazole, sulconazole",0.109578981199086,0.0501222959631252,FALSE +"H1975","Pearson.est","TGF beta receptor inhibitor",0.4375,1.06,0.386,354,0.616,"SB.525334, D.4476, SB.431542",0.413412695328245,0.210419287835575,FALSE +"H1975","Pearson.est","thymidylate synthase inhibitor",0.28819,0.711,0.811,521,0.865,"carmofur, raltitrexed, trifluridine",0.090979145788844,0.0629838925351858,FALSE +"H1975","Pearson.est","topoisomerase inhibitor",-0.21785,-0.599,0.947,310,0.927,"valrubicin, amsacrine, nemorubicin, idarubicin, voreloxin, SN.38, beta.lapachone, doxorubicin, dexrazoxane, exatecan.mesylate, topotecan, teniposide, TAS.103, mitoxantrone, camptothecin, licochalcone.a, epirubicin, amonafide, daunorubicin, irinotecan, rubitecan, etoposide, etoposide.phosphate, genz.644282, fleroxacin",0.0236500209967266,0.0329202658555029,FALSE +"H1975","Pearson.est","tubulin polymerization inhibitor",-0.38131,-1.05,0.379,1144,0.591,"vindesine, dolastatin.10, verubulin, epothilone.b, epothilone.d, vinblastine, paclitaxel, docetaxel, BNC105",0.421360790031928,0.228412519118745,FALSE +"H1975","Pearson.est","tyrosine kinase inhibitor",0.52909,1.3,0.165,316,0.53,"regorafenib, hypericin, bafetinib, NVP.TAE226, tyrphostin.A9, CP.724714, AV.412, sorafenib, vandetanib, BMS.599626",0.782516055786094,0.275724130399211,FALSE +"H1975","Pearson.est","VEGFR inhibitor",0.44578,1.1,0.346,249,0.613,"OSI.930, ENMD.2076, XL.647, regorafenib, BMS.690514, ZM.306416, golvatinib, dovitinib, AEE788, sorafenib, vandetanib",0.460923901207223,0.212539525481585,FALSE +"H1975","Pearson.est","vitamin D receptor agonist",0.59868,1.47,0.0929,477,0.514,"tacalcitol, maxacalcitol, calcitriol, alfacalcidol, ercalcitriol",1.03198428600636,0.289036881004724,FALSE +"H1648","Pearson.est","EGFR inhibitor",-0.89195,-2.17,0,1379,0.0176,"brigatinib, WZ.4002, CUDC.101, rociletinib, icotinib, TAK.285, CP.724714, BIBU.1361, WZ8040, PD.153035, AEE788, AST.1306, GW.583340, vandetanib, BIBX.1382, BMS.599626, ARRY.334543, PD.168393, pelitinib, erlotinib, gefitinib, BMS.690514, osimertinib, lapatinib, tucatinib, afatinib, dacomitinib, canertinib, neratinib, XL.647, AZD8931, poziotinib",Inf,1.75448733218585,TRUE +"H1648","Pearson.est","Abl kinase inhibitor",-0.39874,-0.94,0.518,1393,0.801,"dasatinib, bosutinib, ZM.306416",0.285670240254767,0.0963674839157623,FALSE +"H1648","Pearson.est","acetylcholine receptor agonist",0.46642,1.12,0.326,58,0.623,"oxiracetam",0.486782399932061,0.20551195334083,FALSE +"H1648","Pearson.est","acetylcholine receptor antagonist",0.59632,1.46,0.0741,193,0.639,"iododexetimide, diphemanil",1.13018179202067,0.1944991418416,FALSE +"H1648","Pearson.est","adenosine receptor antagonist",-0.46448,-1.14,0.299,1167,0.742,"PSB.1115, theophylline, MRS.1220, CGS.15943",0.52432881167557,0.129596094720973,FALSE +"H1648","Pearson.est","adrenergic receptor agonist",-0.20377,-0.497,0.978,292,0.98,"buphenine, metaraminol, norepinephrine, isoetharine, clenbuterol, xylazine, epinephrine, lidamidine, oxymetazoline, midodrine, isoxsuprine, ritodrine, methyldopa, terbutaline, A61603",0.00966114521239857,0.00877392430750515,FALSE +"H1648","Pearson.est","adrenergic receptor antagonist",0.17302,0.414,0.997,608,0.996,"metoprolol, oxprenolol, carvedilol, levobunolol, pindolol, idazoxan, naftidrofuryl, atipamezole, practolol",0.00130484168834428,0.00174066157630127,FALSE +"H1648","Pearson.est","AKT inhibitor",-0.66645,-1.66,0.0511,1304,0.243,"GSK2110183, CCT128930, GDC.0068, uprosertib, triciribine",1.29157909986529,0.614393726401688,FALSE +"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.36312,-0.907,0.522,1107,0.825,"CEP.37440, AZD3463, SB.505124, AP26113, GW.788388, brigatinib",0.282329496997738,0.0835460514500749,FALSE +"H1648","Pearson.est","androgen receptor antagonist",0.51742,1.22,0.242,282,0.531,"nilutamide, bicalutamide",0.616184634019569,0.274905478918531,FALSE +"H1648","Pearson.est","antioxidant",0.54248,1.32,0.162,311,0.599,"trolox, benfotiamine, chlorogenic.acid",0.790484985457369,0.222573177610689,FALSE +"H1648","Pearson.est","AP inhibitor",0.43392,1.04,0.407,521,0.638,"idronoxil, embelin, GDC.0152, birinapant, LCL.161",0.39040559077478,0.195179321278838,FALSE +"H1648","Pearson.est","ATPase inhibitor",0.36488,0.887,0.597,606,0.756,"digoxin, blebbistatin...., digitoxin, ouabain, oligomycin.a, thonzonium, digitoxigenin, evodiamine",0.224025668870631,0.121478204498793,FALSE +"H1648","Pearson.est","Aurora kinase inhibitor",0.35299,0.836,0.66,394,0.798,"barasertib, tozasertib, AT.9283, AMG900, SNS.314, KW.2449, PF.03814735, hesperadin",0.180456064458131,0.0979971086492706,FALSE +"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.60627,-1.57,0.0718,1155,0.314,"josamycin, tilmicosin, tedizolid, azithromycin",1.1438755557577,0.503070351926785,FALSE +"H1648","Pearson.est","bacterial DNA gyrase inhibitor",0.25104,0.604,0.906,397,0.998,"novobiocin, sparfloxacin, norfloxacin",0.0428718023231869,0.000869458712628891,FALSE +"H1648","Pearson.est","BCL inhibitor",0.58942,1.43,0.109,351,0.649,"venetoclax, oridonin, TW.37, ABT.737",0.962573502059376,0.187755303199631,FALSE +"H1648","Pearson.est","Bcr.Abl kinase inhibitor",0.44858,1.07,0.394,194,0.67,"GZD824, bafetinib, tozasertib, ponatinib, nilotinib",0.404503778174426,0.173925197299174,FALSE +"H1648","Pearson.est","benzodiazepine receptor agonist",0.23587,0.565,0.935,255,0.985,"indiplon, temazepam",0.0291883891274822,0.00656376950238827,FALSE +"H1648","Pearson.est","bromodomain inhibitor",-0.26344,-0.643,0.864,1062,0.966,"I.BET151, OTX015, JQ1....",0.0634862575211067,0.0150228735845067,FALSE +"H1648","Pearson.est","calcium channel blocker",-0.32252,-0.796,0.692,1152,0.914,"efonidipine.monoethanolate, tetrandrine, fendiline, SKF.96365",0.159893905543242,0.0390538042661686,FALSE +"H1648","Pearson.est","CC chemokine receptor antagonist",0.62746,1.52,0.0638,378,0.648,"UNBS.5162, MK.0812, SB.225002, PF.04136309, navarixin",1.19517932127884,0.188424994129407,FALSE +"H1648","Pearson.est","CDK inhibitor",-0.39396,-1.02,0.41,1143,0.824,"TG.02, P276.00, arcyriaflavin.a, alvocidib, aminopurvalanol.a, indirubin, BMS.387032, AT.7519",0.387216143280265,0.0840727883028842,FALSE +"H1648","Pearson.est","CHK inhibitor",-0.31962,-0.764,0.723,1341,0.896,"LY2603618",0.140861702705469,0.0476919903378748,FALSE +"H1648","Pearson.est","cyclooxygenase inhibitor",-0.28072,-0.711,0.802,1295,0.91,"aspirin, FK.3311, ramifenazone, amfenac, tryptanthrin",0.0958256317158365,0.0409586076789064,FALSE +"H1648","Pearson.est","cytochrome P450 inhibitor",0.51581,1.22,0.237,400,0.531,"metyrapone, morin, cobicistat",0.625251653989896,0.274905478918531,FALSE +"H1648","Pearson.est","DNA alkylating agent",0.38057,0.909,0.557,291,0.757,"melphalan, carboplatin, carmustine, dianhydrogalactitol, TH.302",0.254144804826271,0.120904120499927,FALSE +"H1648","Pearson.est","DNA inhibitor",0.46745,1.13,0.315,368,0.628,"melphalan, carboplatin, chlorambucil, pibenzimol, bendamustine, carmustine, mechlorethamine, valrubicin",0.501689446210399,0.202040356262804,FALSE +"H1648","Pearson.est","DNA methyltransferase inhibitor",-0.53335,-1.33,0.147,1337,0.608,"SGI.1027, decitabine, azacitidine",0.832682665251824,0.216096420727265,FALSE +"H1648","Pearson.est","DNA polymerase inhibitor",-0.21458,-0.536,0.958,309,0.993,"foscarnet, famciclovir, menadione, idoxuridine, trifluridine, adefovir.dipivoxil, cidofovir, cephalomannine",0.0186344909214556,0.00305075150461883,FALSE +"H1648","Pearson.est","DNA synthesis inhibitor",0.42421,1.02,0.453,655,0.632,"azodicarbonamide, nelarabine, artemisinin, floxuridine, artesunate, estramustine.phosphate, mitomycin.c, CB.10.277, cisplatin, anisomycin, enocitabine",0.343901797987168,0.199282921717615,FALSE +"H1648","Pearson.est","dopamine receptor antagonist",0.24329,0.583,0.926,214,0.993,"raclopride, amisulpride, paliperidone",0.0333890133180656,0.00305075150461883,FALSE +"H1648","Pearson.est","estrogen receptor agonist",-0.44743,-1.13,0.32,1350,0.708,"erteberel, levonorgestrel",0.494850021680094,0.149966742310231,FALSE +"H1648","Pearson.est","estrogen receptor antagonist",0.50921,1.24,0.23,168,0.633,"toremifene, danazol, fulvestrant",0.638272163982407,0.198596289982645,FALSE +"H1648","Pearson.est","FGFR inhibitor",0.6934,1.6,0.0202,295,0.661,"erdafitinib, dovitinib, regorafenib, nintedanib, orantinib, MK.2461, lenvatinib",1.69464863055338,0.17979854051436,FALSE +"H1648","Pearson.est","FLT3 inhibitor",0.59841,1.42,0.1,387,0.545,"dovitinib, TG.101348, midostaurin, tozasertib, ponatinib, quizartinib, sunitinib, lestaurtinib, KW.2449, tyrphostin.AG.1296, sorafenib",1,0.263603497723358,FALSE +"H1648","Pearson.est","glucocorticoid receptor agonist",-0.72553,-1.86,0.00948,1183,0.14,"beclomethasone.dipropionate, difluprednate, dexamethasone.acetate, fluocinolone.acetonide, methylprednisolone, fluorometholone, flumethasone.pivalate, fludroxycortide, betamethasone, halcinonide, desonide, halobetasol.propionate, clobetasol.propionate, ciclesonide, flumethasone, triamcinolone.acetonide",2.02319166266193,0.853871964321762,TRUE +"H1648","Pearson.est","glutamate receptor antagonist",0.27994,0.677,0.869,348,0.964,"MTPG, ACDPP, felbamate",0.0609802235513335,0.0159229660971692,FALSE +"H1648","Pearson.est","glycogen synthase kinase inhibitor",0.45216,1.06,0.388,324,0.645,"tideglusib, CHIR.99021, CHIR.98014, GSK.3.inhibitor.IX",0.411168274405793,0.190440285364732,FALSE +"H1648","Pearson.est","growth factor receptor inhibitor",-0.31056,-0.761,0.735,1348,0.868,"GSK1904529A",0.133712660915805,0.0614802748235081,FALSE +"H1648","Pearson.est","HCV inhibitor",0.35215,0.841,0.656,412,0.809,"narlaprevir, mericitabine, embelin",0.18309616062434,0.0920514783877277,FALSE +"H1648","Pearson.est","HDAC inhibitor",0.40851,0.995,0.446,568,0.652,"entinostat, resminostat, R306465, nexturastat.a, RG2833, trichostatin.a, M.344, dacinostat, chidamide, ACY.1215, scriptaid, vorinostat, belinostat, NSC.3852",0.350665141287858,0.18575240426808,FALSE +"H1648","Pearson.est","histamine receptor antagonist",0.22304,0.531,0.959,407,0.985,"lafutidine, famotidine, epinastine, pheniramine, ICI.162846, tiotidine, cimetidine",0.0181813928293364,0.00656376950238827,FALSE +"H1648","Pearson.est","HMGCR inhibitor",0.91748,2.21,0,7,0,"mevastatin, pitavastatin, atorvastatin, fluvastatin",Inf,Inf,TRUE +"H1648","Pearson.est","HSP inhibitor",-0.29883,-0.765,0.761,1261,0.931,"VER.49009, alvespimycin, tanespimycin, KW.2478",0.118615343229427,0.0310503190186574,FALSE +"H1648","Pearson.est","JAK inhibitor",0.36811,0.896,0.574,347,0.76,"TG.101348, tozasertib, AT.9283, TG.101209, lestaurtinib, PRT062070, AZ960",0.241088107602027,0.119186407719209,FALSE +"H1648","Pearson.est","KIT inhibitor",0.51462,1.22,0.235,424,0.531,"pazopanib, midostaurin, regorafenib, KI.8751, masitinib, sunitinib, lenvatinib, sorafenib, telatinib, motesanib",0.628932137728264,0.274905478918531,FALSE +"H1648","Pearson.est","MDM inhibitor",0.83688,1.96,0.00162,120,0.0379,"idasanutlin, AMG.232, nutlin.3, CGM097, serdemetan",2.79048498545737,1.42136079003193,TRUE +"H1648","Pearson.est","MEK inhibitor",-0.57024,-1.4,0.128,1189,0.536,"cobimetinib, PD.198306, MEK162, PD.184352, PD.318088, TAK.733, PD.0325901, selumetinib, AZD8330, Ro.4987655, AS.703026, trametinib",0.892790030352132,0.27083521030723,FALSE +"H1648","Pearson.est","MET inhibitor",-0.39786,-0.979,0.46,1408,0.81,"INC.280",0.337242168318426,0.0915149811213502,FALSE +"H1648","Pearson.est","microtubule inhibitor",0.53761,1.28,0.184,169,0.655,"vinblastine, secnidazole, vinflunine",0.735182176990464,0.183758700008217,FALSE +"H1648","Pearson.est","mTOR inhibitor",-0.23566,-0.581,0.935,1217,0.994,"WYE.354, PP242, PF.05212384, GDC.0980, GSK2126458",0.0291883891274822,0.00261361560268669,FALSE +"H1648","Pearson.est","NFkB pathway inhibitor",-0.34086,-0.846,0.629,1098,0.899,"Ro.106.9920, tyloxapol, EVP4593, IKK.2.inhibitor.V",0.201349354554731,0.0462403082667712,FALSE +"H1648","Pearson.est","opioid receptor agonist",0.50229,1.21,0.249,527,0.528,"BW.180C, cebranopadol, spiradoline, salvinorin.a",0.603800652904264,0.277366077466188,FALSE +"H1648","Pearson.est","p38 MAPK inhibitor",-0.52411,-1.3,0.179,1087,0.599,"VX.702, CMPD.1, talmapimod, SB.239063",0.747146969020107,0.222573177610689,FALSE +"H1648","Pearson.est","PARP inhibitor",0.54602,1.27,0.206,421,0.637,"talazoparib, AG.14361, PJ.34, olaparib, niraparib",0.686132779630847,0.19586056766465,FALSE +"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.57471,1.39,0.146,455,0.523,"dovitinib, axitinib, pazopanib, regorafenib, KI.8751, ponatinib, nintedanib, orantinib, masitinib, sunitinib, lenvatinib, linifanib, trapidil, sorafenib, telatinib, motesanib, CP.673451, SU014813",0.835647144215563,0.281498311132726,FALSE +"H1648","Pearson.est","phosphatase inhibitor",0.60583,1.46,0.0836,210,0.639,"bis.maltolato.oxovanadium.IV., GSK2830371, BVT.948, sodium.stibogluconate, CID.5458317",1.07779372256098,0.1944991418416,FALSE +"H1648","Pearson.est","phosphodiesterase inhibitor",0.50895,1.23,0.232,31,0.59,"anagrelide, GSK256066",0.6345120151091,0.229147988357856,FALSE +"H1648","Pearson.est","PI3K inhibitor",-0.44701,-1.12,0.317,1262,0.68,"PF.05212384, TG.100713, GDC.0980, CH5132799, GSK2126458, alpelisib, taselisib",0.498940737782249,0.167491087293764,FALSE +"H1648","Pearson.est","PLK inhibitor",0.45519,1.08,0.365,404,0.675,"rigosertib, volasertib, GSK461364",0.437707135543525,0.170696227168975,FALSE +"H1648","Pearson.est","potassium channel blocker",0.55655,1.33,0.159,523,0.621,"dofetilide, meglitinide, mepivacaine",0.798602875679548,0.20690839982342,FALSE +"H1648","Pearson.est","PPAR receptor agonist",0.49215,1.17,0.274,632,0.578,"GW.501516, clofibrate, fenofibrate, ciprofibrate, pterostilbene",0.562249437179612,0.238072161579471,FALSE +"H1648","Pearson.est","progesterone receptor agonist",0.4263,1.02,0.448,192,0.632,"norethindrone, danazol, tanaproget",0.348721986001856,0.199282921717615,FALSE +"H1648","Pearson.est","proteasome inhibitor",0.53722,1.26,0.197,367,0.623,"ixazomib, delanzomib, MG.132, ONX.0914, oprozomib",0.705533773838407,0.20551195334083,FALSE +"H1648","Pearson.est","protein synthesis inhibitor",0.33743,0.805,0.716,582,0.827,"brefeldin.a, mercaptopurine, anguidine, harringtonine, homoharringtonine, methacycline, clofoctol, clindamycin.phosphate, cycloheximide, azomycin..2.nitroimidazole.",0.145086977692144,0.0824944904474534,FALSE +"H1648","Pearson.est","protein tyrosine kinase inhibitor",-0.72814,-1.82,0.0172,1232,0.143,"tyrphostin.A9, NVP.TAE226, CP.724714, AV.412, BMS.599626",1.76447155309245,0.844663962534938,TRUE +"H1648","Pearson.est","RAF inhibitor",0.58757,1.42,0.106,147,0.545,"dabrafenib, vemurafenib, regorafenib, TAK.632",0.97469413473523,0.263603497723358,FALSE +"H1648","Pearson.est","RET tyrosine kinase inhibitor",-0.39978,-0.994,0.449,1422,0.826,"vandetanib",0.347753658996677,0.0830199526796178,FALSE +"H1648","Pearson.est","retinoid receptor agonist",0.29503,0.715,0.827,44,0.937,"fenretinide",0.0824944904474534,0.0282604091122217,FALSE +"H1648","Pearson.est","ribonucleotide reductase inhibitor",0.65129,1.56,0.0513,299,0.642,"pentostatin, cladribine, clofarabine, triapine, fludarabine, hydroxyurea",1.28988263488818,0.192464971931147,FALSE +"H1648","Pearson.est","serotonin receptor agonist",0.58453,1.4,0.115,399,0.546,"NAN.190, aripiprazole, SR.57227A",0.939302159646388,0.262807357295263,FALSE +"H1648","Pearson.est","serotonin receptor antagonist",0.40648,0.992,0.463,382,0.64,"lerisetron, SB.200646, paliperidone, aripiprazole, pirenperone",0.334419008982047,0.193820026016113,FALSE +"H1648","Pearson.est","sodium channel blocker",0.26406,0.629,0.901,313,0.995,"oxcarbazepine, quinidine, cibenzoline, triamterene",0.045275209020937,0.00217691925427455,FALSE +"H1648","Pearson.est","src inhibitor",-0.73062,-1.79,0.0188,1393,0.142,"dasatinib, bosutinib, ZM.306416, saracatinib",1.72584215073632,0.847711655616944,TRUE +"H1648","Pearson.est","sterol demethylase inhibitor",0.43852,1.06,0.379,441,0.645,"chlormidazole, ketoconazole, posaconazole, lanoconazole",0.421360790031928,0.190440285364732,FALSE +"H1648","Pearson.est","TGF beta receptor inhibitor",-0.49566,-1.26,0.236,1402,0.615,"repsox",0.627087997029893,0.211124884224583,FALSE +"H1648","Pearson.est","thymidylate synthase inhibitor",-0.3288,-0.814,0.68,1231,0.921,"carmofur, capecitabine",0.167491087293764,0.0357403698031511,FALSE +"H1648","Pearson.est","topoisomerase inhibitor",0.50685,1.23,0.218,457,0.59,"nemorubicin, etoposide.phosphate, topotecan, epirubicin, doxorubicin, teniposide, daunorubicin, voreloxin, etoposide, amonafide, amsacrine, valrubicin, rubitecan, TAS.103, idarubicin, mitoxantrone",0.661543506395395,0.229147988357856,FALSE +"H1648","Pearson.est","tubulin polymerization inhibitor",0.4393,1.05,0.411,343,0.642,"vinblastine, verubulin, BNC105, taltobulin, combretastatin.A.4, vindesine, CYT.997, KX2.391, vincristine",0.386158178123931,0.192464971931147,FALSE +"H1648","Pearson.est","tyrosine kinase inhibitor",-0.47166,-1.16,0.273,1283,0.76,"aminopurvalanol.a, NVP.TAE226, tivantinib, dasatinib, CP.724714, vandetanib, AV.412, BMS.599626",0.563837352959244,0.119186407719209,FALSE +"H1648","Pearson.est","VEGFR inhibitor",-0.36842,-0.964,0.468,1416,0.796,"AEE788, vandetanib, ZM.306416, BMS.690514, XL.647",0.329754146925876,0.0990869322623309,FALSE +"H1648","Pearson.est","vitamin D receptor agonist",-0.80381,-1.99,0.0092,1296,0.0677,"paricalcitol, calcitriol, ercalcitriol, tacalcitol, maxacalcitol",2.03621217265444,1.16941133131486,TRUE +"H2126","Pearson.est","EGFR inhibitor",-0.86724,-2.17,0.00216,1354,0.00217,"icotinib, rociletinib, WZ.4002, pelitinib, WZ8040, TAK.285, BIBU.1361, AST.1306, AEE788, vandetanib, ARRY.334543, PD.153035, BIBX.1382, erlotinib, CP.724714, BMS.599626, GW.583340, CUDC.101, afatinib, dacomitinib, PD.168393, gefitinib, canertinib, osimertinib, BMS.690514, lapatinib, XL.647, neratinib, poziotinib, AZD8931, tucatinib",2.66554624884907,2.66354026615147,TRUE +"H2126","Pearson.est","Abl kinase inhibitor",0.45125,1.11,0.324,246,0.633,"ponatinib, GZD824, tozasertib, KW.2449, bafetinib, nilotinib",0.489454989793388,0.198596289982645,FALSE +"H2126","Pearson.est","acetylcholine receptor agonist",-0.26374,-0.666,0.871,1099,0.965,"pilocarpine, nefiracetam, nicotine",0.0599818449923368,0.0154726866562074,FALSE +"H2126","Pearson.est","acetylcholine receptor antagonist",0.32382,0.789,0.69,152,0.807,"iododexetimide",0.161150909262745,0.0931264652779296,FALSE +"H2126","Pearson.est","adenosine receptor antagonist",-0.7266,-1.76,0.0281,1366,0.145,"SCH.58261, MRS.1220, CGS.15943",1.55129368009492,0.838631997765025,TRUE +"H2126","Pearson.est","adrenergic receptor agonist",-0.26169,-0.641,0.877,375,0.963,"midodrine, buphenine, clenbuterol, lidamidine, terbutaline, norepinephrine, methyldopa, isoetharine, oxymetazoline, xylazine, epinephrine, ritodrine, metaraminol, A61603, isoxsuprine",0.0570004066339595,0.0163737128754655,FALSE +"H2126","Pearson.est","adrenergic receptor antagonist",0.21324,0.528,0.979,229,1,"metoprolol, idazoxan, oxprenolol, carvedilol",0.00921730819686218,0,FALSE +"H2126","Pearson.est","AKT inhibitor",-0.70537,-1.71,0.0375,1209,0.167,"palomid.529, A.674563, CCT128930, triciribine, GSK2110183, uprosertib, GDC.0068",1.42596873227228,0.777283528852417,TRUE +"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.2547,-0.622,0.884,1087,0.953,"SB.505124, AP26113, GW.788388, CEP.37440, brigatinib",0.0535477349869269,0.0209070993616736,FALSE +"H2126","Pearson.est","androgen receptor antagonist",0.43757,1.04,0.413,406,0.661,"nilutamide, bicalutamide, cyproterone.acetate",0.384049948343599,0.17979854051436,FALSE +"H2126","Pearson.est","antioxidant",0.50052,1.25,0.203,707,0.512,"benfotiamine, trolox, chlorogenic.acid, taurine, rutin",0.692503962086787,0.290730039024169,FALSE +"H2126","Pearson.est","AP inhibitor",0.3872,0.941,0.524,511,0.745,"idronoxil, GDC.0152, LCL.161, embelin, birinapant",0.280668713016273,0.127843727251707,FALSE +"H2126","Pearson.est","ATPase inhibitor",0.52196,1.27,0.211,281,0.527,"ouabain, digitoxin, thonzonium, digoxin, digitoxigenin, blebbistatin....",0.675717544702307,0.278189384787453,FALSE +"H2126","Pearson.est","Aurora kinase inhibitor",0.41638,1.02,0.414,275,0.674,"barasertib, tozasertib, AMG900, AT.9283, KW.2449, SNS.314, barasertib.HQPA, PF.03814735, hesperadin",0.382999658879101,0.17134010346468,FALSE +"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.45003,-1.09,0.338,1045,0.742,"azalomycin.b, tilmicosin, tedizolid, azithromycin",0.471083299722345,0.129596094720973,FALSE +"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.47933,1.15,0.307,141,0.612,"sparfloxacin, novobiocin",0.512861624522813,0.213248577854439,FALSE +"H2126","Pearson.est","BCL inhibitor",0.28421,0.681,0.839,644,0.913,"ABT.737, venetoclax, TW.37, obatoclax, navitoclax",0.0762380391712997,0.039529222465701,FALSE +"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.5544,1.37,0.15,246,0.488,"ponatinib, GZD824, tozasertib, bafetinib, nilotinib",0.823908740944319,0.311580177997289,FALSE +"H2126","Pearson.est","benzodiazepine receptor agonist",-0.16585,-0.407,0.998,238,0.998,"indiplon, temazepam, piperazine, gamma.aminobutyric.acid, CL.218872, zaleplon, bentazepam, eprinomectin, ZK.93423, CGS.20625, ivermectin, nefiracetam, lorazepam",0.000869458712628891,0.000869458712628891,FALSE +"H2126","Pearson.est","bromodomain inhibitor",-0.72706,-1.77,0.0169,1257,0.17,"I.BET151, OTX015, JQ1....",1.77211329538633,0.769551078621726,TRUE +"H2126","Pearson.est","calcium channel blocker",-0.38939,-0.934,0.521,1037,0.839,"SR.33805, mibefradil, tetrandrine, SKF.96365, fendiline",0.283162276700476,0.0762380391712997,FALSE +"H2126","Pearson.est","CC chemokine receptor antagonist",0.5135,1.27,0.22,330,0.527,"UNBS.5162, SB.225002, MK.0812",0.657577319177794,0.278189384787453,FALSE +"H2126","Pearson.est","CDK inhibitor",-0.40547,-0.99,0.449,1278,0.814,"TG.02, aminopurvalanol.a, AT.7519, BMS.387032, arcyriaflavin.a, indirubin",0.347753658996677,0.0893755951107988,FALSE +"H2126","Pearson.est","CHK inhibitor",0.54258,1.32,0.183,185,0.521,"SCH.900776, PF.477736, LY2606368",0.737548910269571,0.283162276700476,FALSE +"H2126","Pearson.est","cyclooxygenase inhibitor",-0.27752,-0.69,0.825,1107,0.965,"meloxicam, FR.122047, ramifenazone, FK.3311, aspirin, amfenac, tryptanthrin",0.0835460514500749,0.0154726866562074,FALSE +"H2126","Pearson.est","cytochrome P450 inhibitor",0.56422,1.35,0.151,523,0.496,"metyrapone, morin, itraconazole, clotrimazole, cobicistat",0.821023052706831,0.304518323509803,FALSE +"H2126","Pearson.est","DNA alkylating agent",0.35312,0.843,0.61,404,0.763,"melphalan, carboplatin, carmustine, estramustine, temozolomide, streptozotocin",0.214670164989233,0.11747546204512,FALSE +"H2126","Pearson.est","DNA inhibitor",0.37844,0.922,0.548,125,0.757,"melphalan, chlorambucil, carboplatin",0.261219441515631,0.120904120499927,FALSE +"H2126","Pearson.est","DNA methyltransferase inhibitor",-0.45724,-1.12,0.31,1170,0.729,"fdcyd, decitabine, SGI.1027, azacitidine",0.508638306165727,0.137272471682025,FALSE +"H2126","Pearson.est","DNA polymerase inhibitor",-0.19931,-0.49,0.983,287,1,"trifluridine, foscarnet, adefovir.dipivoxil, famciclovir, idoxuridine, menadione, cephalomannine, cidofovir",0.00744648216786438,0,FALSE +"H2126","Pearson.est","DNA synthesis inhibitor",0.45866,1.11,0.333,636,0.633,"nelarabine, floxuridine, artemisinin, azodicarbonamide, cisplatin, anisomycin, altretamine, artesunate, cyclocytidine, capecitabine",0.47755576649368,0.198596289982645,FALSE +"H2126","Pearson.est","dopamine receptor antagonist",-0.29074,-0.715,0.768,1053,0.998,"piperacetazine, mesoridazine, acetophenazine, oxiperomide, ziprasidone, lurasidone, nemonapride, clebopride, remoxipride",0.114638779968488,0.000869458712628891,FALSE +"H2126","Pearson.est","estrogen receptor agonist",-0.29167,-0.692,0.815,420,0.997,"estrone, estradiol, PPT, estradiol.cypionate, equol, ethinyl.estradiol, levonorgestrel, erteberel",0.0888423912600234,0.00130484168834428,FALSE +"H2126","Pearson.est","estrogen receptor antagonist",0.33035,0.809,0.669,357,0.797,"toremifene, danazol, fulvestrant",0.174573882232177,0.0985416786038876,FALSE +"H2126","Pearson.est","FGFR inhibitor",0.7074,1.74,0.0197,215,0.443,"erdafitinib, dovitinib, regorafenib, lenvatinib, MK.2461",1.70553377383841,0.35359627377693,FALSE +"H2126","Pearson.est","FLT3 inhibitor",0.5369,1.3,0.19,198,0.529,"ponatinib, dovitinib, tozasertib, lestaurtinib, midostaurin, tyrphostin.AG.1296, KW.2449, gilteritinib, sunitinib",0.721246399047171,0.276544327964814,FALSE +"H2126","Pearson.est","glucocorticoid receptor agonist",-0.56321,-1.4,0.118,1068,0.489,"betamethasone, fluocinolone.acetonide, beclomethasone.dipropionate, flumethasone.pivalate, desonide, difluprednate, rimexolone, fludroxycortide, ciclesonide, halobetasol.propionate, halcinonide, methylprednisolone, flumethasone, clobetasol.propionate, triamcinolone.acetonide",0.928117992693875,0.31069114087638,FALSE +"H2126","Pearson.est","glutamate receptor antagonist",-0.40577,-0.994,0.457,1125,0.851,"LY456236, CPP, latrepirdine, tiletamine, CGP.37849",0.34008379993015,0.0700704399154121,FALSE +"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.31878,-0.783,0.718,1417,1,"indirubin",0.1438755557577,0,FALSE +"H2126","Pearson.est","growth factor receptor inhibitor",0.39608,0.971,0.462,236,0.738,"lestaurtinib, PHA.848125, GSK1838705A",0.335358024443874,0.131943638176958,FALSE +"H2126","Pearson.est","HCV inhibitor",0.3922,0.961,0.479,532,0.732,"narlaprevir, mericitabine, embelin, Ro.9187",0.319664486585437,0.135488918941608,FALSE +"H2126","Pearson.est","HDAC inhibitor",-0.60432,-1.5,0.0887,1214,0.359,"M.344, AR.42, tacedinaline, mocetinostat, pyroxamide, PCI.24781, givinostat, romidepsin, JNJ.26481585, SB.939",1.05207638016827,0.444905551421681,FALSE +"H2126","Pearson.est","histamine receptor antagonist",0.20735,0.505,0.969,378,0.997,"cimetidine, pheniramine, tiotidine, famotidine, lafutidine, astemizole",0.0136762229492347,0.00130484168834428,FALSE +"H2126","Pearson.est","HMGCR inhibitor",0.9542,2.32,0,6,0,"atorvastatin, mevastatin, fluvastatin, pitavastatin",Inf,Inf,TRUE +"H2126","Pearson.est","HSP inhibitor",0.34524,0.848,0.636,165,0.776,"NMS.E973, SNX.2112, NVP.AUY922, ganetespib",0.196542884351586,0.110138278741812,FALSE +"H2126","Pearson.est","JAK inhibitor",0.30446,0.731,0.787,228,0.868,"tozasertib, lestaurtinib, AT.9283, PRT062070",0.104025267640935,0.0614802748235081,FALSE +"H2126","Pearson.est","KIT inhibitor",0.58701,1.44,0.0951,396,0.422,"KI.8751, midostaurin, pazopanib, regorafenib, lenvatinib, motesanib, sunitinib, telatinib, cediranib, sorafenib",1.02181948306259,0.374687549038326,FALSE +"H2126","Pearson.est","MDM inhibitor",-0.37397,-0.904,0.541,1410,0.858,"RITA",0.266802734893431,0.0665127121512946,FALSE +"H2126","Pearson.est","MEK inhibitor",-0.46812,-1.15,0.3,1060,0.716,"AZD8330, PD.0325901, TAK.733, MEK162, PD.184352, Ro.4987655, AS.703026, selumetinib, PD.198306, trametinib",0.522878745280338,0.145086977692144,FALSE +"H2126","Pearson.est","MET inhibitor",0.35939,0.873,0.581,292,0.796,"LY2801653, AMG458, PHA.665752",0.235823867609669,0.0990869322623309,FALSE +"H2126","Pearson.est","microtubule inhibitor",0.67072,1.66,0.0394,223,0.53,"vinblastine, vinflunine, podophyllotoxin, cabazitaxel, secnidazole",1.40450377817443,0.275724130399211,FALSE +"H2126","Pearson.est","mTOR inhibitor",-0.50166,-1.22,0.253,1077,0.631,"LY303511, AZD8055, torin.2, voxtalisib, WYE.354, XL388, palomid.529, PF.05212384, WYE.125132, PP242, PI.103, GDC.0980, GSK2126458",0.596879478824182,0.199970640755866,FALSE +"H2126","Pearson.est","NFkB pathway inhibitor",-0.31237,-0.762,0.742,1142,0.96,"IKK.2.inhibitor.V, Ro.106.9920, EVP4593, tyloxapol",0.129596094720973,0.0177287669604316,FALSE +"H2126","Pearson.est","opioid receptor agonist",0.44966,1.09,0.36,461,0.643,"spiradoline, BW.180C, cebranopadol",0.443697499232713,0.191789027075778,FALSE +"H2126","Pearson.est","p38 MAPK inhibitor",-0.51297,-1.27,0.189,884,0.581,"TAK.715, talmapimod, CMPD.1, VX.702, SB.239063",0.723538195826756,0.235823867609669,FALSE +"H2126","Pearson.est","PARP inhibitor",0.6418,1.56,0.0664,341,0.472,"talazoparib, olaparib, niraparib, AZD2461",1.17783192063198,0.326058001365912,FALSE +"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.61003,1.52,0.0811,198,0.35,"ponatinib, dovitinib, axitinib, SU014813, KI.8751, pazopanib, CP.673451, regorafenib, lenvatinib, motesanib, sunitinib",1.09097914578884,0.455931955649724,FALSE +"H2126","Pearson.est","phosphatase inhibitor",0.50164,1.22,0.25,139,0.515,"bis.maltolato.oxovanadium.IV., BVT.948, GSK2830371, sodium.stibogluconate",0.602059991327962,0.288192770958809,FALSE +"H2126","Pearson.est","phosphodiesterase inhibitor",0.35648,0.861,0.593,78,0.774,"anagrelide, GSK256066",0.226945306635737,0.111259039317107,FALSE +"H2126","Pearson.est","PI3K inhibitor",-0.53664,-1.37,0.155,1176,0.493,"voxtalisib, PI3K.IN.2, CUDC.907, PI.828, TG.100713, PF.05212384, PI.103, GDC.0980, CH5132799, GSK2126458, alpelisib, taselisib",0.809668301829709,0.30715308072277,FALSE +"H2126","Pearson.est","PLK inhibitor",0.66608,1.65,0.0264,137,0.424,"rigosertib, volasertib, GSK461364",1.57839607313017,0.372634143407267,FALSE +"H2126","Pearson.est","potassium channel blocker",0.26828,0.657,0.861,148,0.922,"dofetilide",0.0649968485463452,0.0352690789463706,FALSE +"H2126","Pearson.est","PPAR receptor agonist",0.51265,1.23,0.229,362,0.521,"fenofibrate, clofibrate",0.640164517660112,0.283162276700476,FALSE +"H2126","Pearson.est","progesterone receptor agonist",0.42929,1.06,0.362,389,0.672,"norethindrone, danazol, tanaproget, norgestrel",0.441291429466834,0.172630726946175,FALSE +"H2126","Pearson.est","proteasome inhibitor",0.6389,1.55,0.081,508,0.428,"ixazomib, delanzomib, bortezomib, MG.132, ONX.0914, carfilzomib, oprozomib",1.09151498112135,0.368556230986828,FALSE +"H2126","Pearson.est","protein synthesis inhibitor",0.35243,0.866,0.607,464,0.786,"mercaptopurine, brefeldin.a, methacycline, homoharringtonine, anguidine, harringtonine, clofoctol, cycloheximide",0.216811308924742,0.104577453960592,FALSE +"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.77092,-1.94,0.00858,1243,0.0561,"NVP.TAE226, mubritinib, tyrphostin.A9, AV.412, CP.724714, BMS.599626",2.06651271215129,1.25103713874384,TRUE +"H2126","Pearson.est","RAF inhibitor",0.61355,1.51,0.069,423,0.335,"dabrafenib, vemurafenib, RAF265, regorafenib, GDC.0879, LGX818, sorafenib, AZ.628",1.16115090926274,0.474955192963155,FALSE +"H2126","Pearson.est","RET tyrosine kinase inhibitor",-0.38902,-0.958,0.501,1415,0.832,"vandetanib",0.300162274132754,0.0798766737092761,FALSE +"H2126","Pearson.est","retinoid receptor agonist",-0.31062,-0.768,0.731,1306,0.988,"CD.437, AM.580",0.13608262304214,0.00524305541237188,FALSE +"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.6275,1.53,0.0739,400,0.417,"cladribine, clofarabine, triapine, pentostatin, fludarabine.phosphate, gemcitabine, fludarabine, hydroxyurea",1.13135556160517,0.379863945026242,FALSE +"H2126","Pearson.est","serotonin receptor agonist",0.57007,1.39,0.141,203,0.485,"aripiprazole, NAN.190, SR.57227A",0.85078088734462,0.314258261397736,FALSE +"H2126","Pearson.est","serotonin receptor antagonist",0.36068,0.884,0.618,104,0.799,"lerisetron, aripiprazole, paliperidone",0.209011524911184,0.0974532206860086,FALSE +"H2126","Pearson.est","sodium channel blocker",0.16836,0.412,0.998,556,0.997,"quinidine, cibenzoline, oxcarbazepine, mexiletine, mepivacaine, benzocaine",0.000869458712628891,0.00130484168834428,FALSE +"H2126","Pearson.est","src inhibitor",-0.64915,-1.58,0.058,1379,0.286,"bosutinib, saracatinib, ZM.306416",1.23657200643706,0.543633966870957,FALSE +"H2126","Pearson.est","sterol demethylase inhibitor",0.42516,1.04,0.397,347,0.661,"chlormidazole, ketoconazole, posaconazole",0.401209493236885,0.17979854051436,FALSE +"H2126","Pearson.est","TGF beta receptor inhibitor",-0.41244,-1.01,0.404,1300,0.866,"repsox",0.393618634889395,0.0624821079826534,FALSE +"H2126","Pearson.est","thymidylate synthase inhibitor",0.5018,1.26,0.203,636,0.521,"trifluridine, raltitrexed, ftorafur, capecitabine",0.692503962086787,0.283162276700476,FALSE +"H2126","Pearson.est","topoisomerase inhibitor",0.6422,1.6,0.0594,373,0.455,"topotecan, etoposide.phosphate, nemorubicin, teniposide, irinotecan, daunorubicin, rubitecan, doxorubicin, etoposide, voreloxin, dexrazoxane, mitoxantrone, TAS.103, amonafide, SN.38, idarubicin, amsacrine",1.22621355501881,0.341988603342888,FALSE +"H2126","Pearson.est","tubulin polymerization inhibitor",0.63468,1.52,0.0797,356,0.35,"verubulin, BNC105, vinblastine, taltobulin, vindesine, CYT.997, podophyllotoxin, vincristine, combretastatin.A.4, dolastatin.10, KX2.391, docetaxel, plinabulin, paclitaxel, ABT.751, fosbretabulin",1.09854167860389,0.455931955649724,FALSE +"H2126","Pearson.est","tyrosine kinase inhibitor",-0.52153,-1.27,0.191,1243,0.581,"NVP.TAE226, aminopurvalanol.a, GTP.14564, mubritinib, tyrphostin.A9, AV.412, vandetanib, CP.724714, BMS.599626",0.718966632752272,0.235823867609669,FALSE +"H2126","Pearson.est","VEGFR inhibitor",-0.37074,-0.902,0.563,1393,0.824,"semaxanib, AEE788, vandetanib, ZM.306416, BMS.690514, XL.647",0.249491605148654,0.0840727883028842,FALSE +"H2126","Pearson.est","vitamin D receptor agonist",-0.88006,-2.19,0,1320,0.00434,"alfacalcidol, ercalcitriol, paricalcitol, calcitriol, maxacalcitol, tacalcitol",Inf,2.36251027048749,TRUE +"H520","Pearson.est","EGFR inhibitor",0.49961,1.35,0.162,216,0.479,"PD.153035, icotinib, vandetanib, poziotinib, erlotinib, osimertinib, pelitinib, canertinib, XL.647, gefitinib, tyrphostin.AG.494, BIBU.1361, PD.168393, dacomitinib, AZD8931, lapatinib, afatinib",0.790484985457369,0.319664486585437,FALSE +"H520","Pearson.est","Abl kinase inhibitor",0.64733,1.71,0.0522,368,0.246,"dasatinib, ponatinib, GZD824, ZM.306416, bosutinib, metatinib, nilotinib, bafetinib",1.28232949699774,0.609064892896621,FALSE +"H520","Pearson.est","acetylcholine receptor agonist",-0.33752,-0.83,0.677,1360,0.944,"xanomeline",0.169411331314856,0.025028005701931,FALSE +"H520","Pearson.est","acetylcholine receptor antagonist",-0.34912,-0.843,0.626,1302,1,"diphemanil",0.20342566678957,0,FALSE +"H520","Pearson.est","adenosine receptor antagonist",-0.2738,-0.668,0.869,1152,0.933,"sulmazole",0.0609802235513335,0.0301183562535,FALSE +"H520","Pearson.est","adrenergic receptor agonist",0.5232,1.42,0.133,91,0.424,"isoxsuprine, ritodrine, oxymetazoline, epinephrine",0.876148359032914,0.372634143407267,FALSE +"H520","Pearson.est","adrenergic receptor antagonist",-0.35943,-0.897,0.589,939,0.922,"RS.17053, atipamezole, practolol, carvedilol, propranolol, metoprolol, pindolol, dihydroergocristine",0.229884705212898,0.0352690789463706,FALSE +"H520","Pearson.est","AKT inhibitor",-0.46606,-1.14,0.276,1146,0.782,"ONC201, GSK2110183, uprosertib, A.674563, GDC.0068",0.559090917934782,0.106793246940152,FALSE +"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.27771,0.726,0.765,62,1,"GW.788388, lorlatinib",0.116338564846382,0,FALSE +"H520","Pearson.est","androgen receptor antagonist",0.24341,0.65,0.893,1097,1,"bicalutamide, RU.58841, nilutamide, cyproterone.acetate, enzalutamide, flutamide",0.0491485411114536,0,FALSE +"H520","Pearson.est","antioxidant",0.60798,1.63,0.0354,290,0.215,"mesna, chlorogenic.acid, rutin",1.45099673797421,0.667561540084395,TRUE +"H520","Pearson.est","AP inhibitor",0.76211,2,0.00556,96,0.114,"GDC.0152, birinapant, LCL.161",2.25492520841794,0.943095148663527,TRUE +"H520","Pearson.est","ATPase inhibitor",-0.4592,-1.11,0.369,1148,0.814,"NMS.873, rabeprazole, digoxin, evodiamine, oligomycin.a",0.43297363384094,0.0893755951107988,FALSE +"H520","Pearson.est","Aurora kinase inhibitor",-0.75696,-1.86,0.00312,1252,0.13,"ENMD.2076, alisertib, AMG900, PF.03814735, MK.8745, SNS.314, TAK.901, AT.9283, danusertib, ZM.447439, barasertib, CCT137690, barasertib.HQPA, PHA.680632",2.50584540598156,0.886056647693163,TRUE +"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.22639,0.595,0.955,1122,0.991,"tedizolid, dirithromycin, tilmicosin, azithromycin, azalomycin.b, valnemulin, radezolid, josamycin",0.0199966284162537,0.00392634551472468,FALSE +"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.30754,0.837,0.638,385,1,"finafloxacin, sparfloxacin, novobiocin, sarafloxacin, trovafloxacin",0.195179321278838,0,FALSE +"H520","Pearson.est","BCL inhibitor",-0.2786,-0.685,0.834,915,0.954,"ABT.737, oridonin, navitoclax, TW.37",0.0788339493622613,0.0204516252959049,FALSE +"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.65125,1.71,0.0395,368,0.246,"dasatinib, ponatinib, GZD824, bosutinib, metatinib, nilotinib, bafetinib",1.40340290437354,0.609064892896621,TRUE +"H520","Pearson.est","benzodiazepine receptor agonist",0.20279,0.539,0.961,1157,0.997,"piperazine, lorazepam, eprinomectin, CGS.20625, gamma.aminobutyric.acid, CL.218872, temazepam, indiplon, nefiracetam, ivermectin, ZK.93423, zaleplon, bentazepam",0.0172766123314547,0.00130484168834428,FALSE +"H520","Pearson.est","bromodomain inhibitor",-0.85229,-2.09,0,1229,0.0145,"JQ1...., PFI.1, I.BET.762, bromosporine, I.BET151, OTX015",Inf,1.83863199776503,TRUE +"H520","Pearson.est","calcium channel blocker",0.24339,0.639,0.877,1098,1,"SKF.96365, efonidipine.monoethanolate, cinnarazine, fendiline, SR.33805, pranidipine, mibefradil, carboxyamidotriazole, tetrandrine, penfluridol",0.0570004066339595,0,FALSE +"H520","Pearson.est","CC chemokine receptor antagonist",0.30934,0.833,0.651,29,1,"navarixin",0.186419011431808,0,FALSE +"H520","Pearson.est","CDK inhibitor",-0.409,-0.998,0.459,1210,0.829,"PHA.793887, abemaciclib, TG.02, R547, arcyriaflavin.a, indisulam",0.338187314462739,0.0814454694497265,FALSE +"H520","Pearson.est","CHK inhibitor",-0.59313,-1.47,0.0864,1338,0.477,"SB.218078, PF.477736",1.06348625752111,0.321481620959886,FALSE +"H520","Pearson.est","cyclooxygenase inhibitor",-0.26814,-0.655,0.866,949,0.927,"meloxicam, suxibuzone, FR.122047, pterostilbene, piroxicam, tepoxalin, AM.404, sulfasalazine, naproxen",0.0624821079826534,0.0329202658555029,FALSE +"H520","Pearson.est","cytochrome P450 inhibitor",0.61072,1.7,0.0452,105,0.215,"morin, metyrapone",1.34486156518862,0.667561540084395,TRUE +"H520","Pearson.est","DNA alkylating agent",-0.43159,-1.07,0.386,1167,0.836,"dianhydrogalactitol, melphalan, TH.302, satraplatin, mitomycin.c",0.413412695328245,0.0777937225609836,FALSE +"H520","Pearson.est","DNA inhibitor",-0.46315,-1.14,0.3,1206,0.782,"pibenzimol, melphalan, tirapazamine, chlorambucil, primaquine, bendamustine, mechlorethamine, valrubicin",0.522878745280338,0.106793246940152,FALSE +"H520","Pearson.est","DNA methyltransferase inhibitor",-0.64775,-1.6,0.0359,1115,0.348,"disulfiram, fdcyd, SGI.1027",1.44490555142168,0.458420756053419,FALSE +"H520","Pearson.est","DNA polymerase inhibitor",-0.27711,-0.671,0.858,1055,0.95,"cephalomannine, famciclovir, idoxuridine",0.0665127121512946,0.0222763947111523,FALSE +"H520","Pearson.est","DNA synthesis inhibitor",-0.29304,-0.723,0.813,1164,1,"artemisinin, enocitabine, azodicarbonamide, mitomycin.c",0.0899094544059319,0,FALSE +"H520","Pearson.est","dopamine receptor antagonist",0.34358,0.906,0.54,299,1,"clebopride, acetophenazine, isofloxythepin, oxiperomide, piperacetazine",0.267606240177031,0,FALSE +"H520","Pearson.est","estrogen receptor agonist",-0.25278,-0.626,0.9,364,0.935,"PPT, estradiol, levonorgestrel, erteberel, estrone, ethinyl.estradiol, estradiol.cypionate, equol",0.0457574905606751,0.0291883891274822,FALSE +"H520","Pearson.est","estrogen receptor antagonist",-0.22649,-0.56,0.948,1040,0.969,"danazol, toremifene",0.0231916626619338,0.0136762229492347,FALSE +"H520","Pearson.est","FGFR inhibitor",-0.47952,-1.17,0.262,1037,0.893,"erdafitinib, dovitinib, lenvatinib, regorafenib, nintedanib",0.581698708680255,0.0491485411114536,FALSE +"H520","Pearson.est","FLT3 inhibitor",-0.44257,-1.08,0.393,1129,0.85,"quizartinib, sorafenib, dovitinib, pacritinib, TG.02, ENMD.2076, TG.101348",0.405607449624573,0.0705810742857073,FALSE +"H520","Pearson.est","glucocorticoid receptor agonist",0.30408,0.782,0.681,77,1,"hydrocortisone, fluocinolone.acetonide, dexamethasone.acetate",0.166852888087215,0,FALSE +"H520","Pearson.est","glutamate receptor antagonist",0.29937,0.79,0.718,173,1,"SIB.1757, diazooxonorleucine, latrepirdine, MTPG",0.1438755557577,0,FALSE +"H520","Pearson.est","glycogen synthase kinase inhibitor",0.40645,1.08,0.34,183,0.785,"LY2090314, CHIR.98014, tideglusib",0.468521082957745,0.105130343254747,FALSE +"H520","Pearson.est","growth factor receptor inhibitor",-0.29785,-0.726,0.808,1385,1,"danusertib",0.0925886392254138,0,FALSE +"H520","Pearson.est","HCV inhibitor",-0.41349,-1.01,0.44,1187,0.866,"mericitabine, narlaprevir",0.356547323513813,0.0624821079826534,FALSE +"H520","Pearson.est","HDAC inhibitor",-0.56194,-1.38,0.137,1131,0.547,"NSC.3852, vorinostat, ACY.1215, trichostatin.a, R306465, resminostat, RGFP966, chidamide, dacinostat, PCI.24781, pyroxamide, SB.939, scriptaid, givinostat, M.344",0.863279432843593,0.262012673666569,FALSE +"H520","Pearson.est","histamine receptor antagonist",0.15643,0.418,0.994,227,0.997,"astemizole, ranitidine, terfenadine",0.00261361560268669,0.00130484168834428,FALSE +"H520","Pearson.est","HMGCR inhibitor",0.75698,1.97,0.00282,214,0.0928,"fluvastatin, lovastatin, pitavastatin, mevastatin",2.54975089168064,1.03245202378114,TRUE +"H520","Pearson.est","HSP inhibitor",-0.40548,-1,0.479,809,0.856,"PU.H71, guanidine, SNX.2112, KW.2478, VER.49009, tanespimycin, NMS.E973",0.319664486585437,0.0675262353228468,FALSE +"H520","Pearson.est","JAK inhibitor",-0.46296,-1.14,0.298,1153,0.782,"pacritinib, TG.02, AZ960, LY2784544, TG.101348, AT.9283",0.525783735923745,0.106793246940152,FALSE +"H520","Pearson.est","KIT inhibitor",-0.36927,-0.902,0.598,1132,0.942,"sorafenib, vatalanib, OSI.930, lenvatinib, masitinib, regorafenib, pazopanib",0.223298816011589,0.0259490972071227,FALSE +"H520","Pearson.est","MDM inhibitor",0.27601,0.71,0.803,1050,1,"idasanutlin, nutlin.3, AMG.232, CGM097, RITA, serdemetan",0.095284454721319,0,FALSE +"H520","Pearson.est","MEK inhibitor",0.79186,2.17,0,63,0.058,"TAK.733, refametinib, AZD8330, cobimetinib, trametinib, Ro.4987655, PD.0325901, AS.703026, PD.318088, selumetinib, MEK162",Inf,1.23657200643706,TRUE +"H520","Pearson.est","MET inhibitor",-0.38068,-0.932,0.527,1046,0.941,"INC.280, NVP.BVU972, AMG458",0.278189384787453,0.0264103765727431,FALSE +"H520","Pearson.est","microtubule inhibitor",-0.45925,-1.14,0.312,827,0.782,"secnidazole, vinblastine, estramustine.phosphate, cabazitaxel, D.64131, colchicine, vinflunine",0.505845405981557,0.106793246940152,FALSE +"H520","Pearson.est","mTOR inhibitor",0.46906,1.24,0.231,419,0.578,"WAY.600, LY3023414, temsirolimus, torin.1, SB.2343, OSI.027, AZD2014, NVP.BEZ235, everolimus, PP242, MLN0128, XL388, LY303511, sirolimus, PF.04691502, AZD8055",0.636388020107856,0.238072161579471,FALSE +"H520","Pearson.est","NFkB pathway inhibitor",-0.28545,-0.696,0.824,1423,0.962,"BAY.11.7082",0.0840727883028842,0.0168249279621871,FALSE +"H520","Pearson.est","opioid receptor agonist",0.47643,1.28,0.167,100,0.554,"ADL5859, BW.180C",0.777283528852417,0.25649023527157,FALSE +"H520","Pearson.est","p38 MAPK inhibitor",-0.32939,-0.815,0.669,1312,0.945,"talmapimod",0.174573882232177,0.0245681914907371,FALSE +"H520","Pearson.est","PARP inhibitor",-0.61147,-1.54,0.064,1208,0.37,"olaparib, AZD2461, PJ.34, niraparib, talazoparib",1.19382002601611,0.431798275933005,FALSE +"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.37252,-0.914,0.559,1132,0.948,"sorafenib, vatalanib, dovitinib, linifanib, trapidil, crenolanib, lenvatinib, masitinib, regorafenib, pazopanib, nintedanib",0.252588192113577,0.0231916626619338,FALSE +"H520","Pearson.est","phosphatase inhibitor",-0.28858,-0.709,0.812,1103,0.967,"AS.1949490, CID.5458317, mycophenolate.mofetil",0.0904439707588247,0.0145735259169983,FALSE +"H520","Pearson.est","phosphodiesterase inhibitor",-0.29976,-0.748,0.785,1043,1,"enoximone, avanafil, cilostamide",0.105130343254747,0,FALSE +"H520","Pearson.est","PI3K inhibitor",-0.14543,-0.355,1,882,0.999,"PKI.179, PI.103, YM.201636, PF.05212384, idelalisib, alpelisib, PI3K.IN.2, CH5132799, CUDC.907, taselisib",0,0.000434511774017692,FALSE +"H520","Pearson.est","PLK inhibitor",-0.67592,-1.64,0.0368,974,0.328,"GW.843682X, rigosertib, GSK461364, HMN.214, BI.2536, NMS.1286937, volasertib",1.43415218132648,0.484126156288321,FALSE +"H520","Pearson.est","potassium channel blocker",0.2337,0.619,0.915,1111,1,"meglitinide, mepivacaine, oleoylethanolamide, ML133, ibutilide, dofetilide",0.0385789059335517,0,FALSE +"H520","Pearson.est","PPAR receptor agonist",-0.50435,-1.22,0.233,1358,0.81,"ciprofibrate, GW.501516",0.632644078973981,0.0915149811213502,FALSE +"H520","Pearson.est","progesterone receptor agonist",0.28006,0.736,0.749,1045,1,"norethindrone, nomegestrol.acetate, levonorgestrel, dienogest, melengestrol.acetate, norethindrone.acetate, norgestrel, danazol, tanaproget",0.125518182300534,0,FALSE +"H520","Pearson.est","proteasome inhibitor",-0.34265,-0.836,0.64,1022,0.959,"delanzomib, oprozomib, MG.132",0.193820026016113,0.0181813928293364,FALSE +"H520","Pearson.est","protein synthesis inhibitor",-0.50392,-1.24,0.22,1310,0.811,"azomycin..2.nitroimidazole., clofoctol, harringtonine, bruceantin, homoharringtonine, anguidine",0.657577319177794,0.090979145788844,FALSE +"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.42566,-1.06,0.388,874,0.791,"rheochrysidin, NVP.TAE226, AV.412, tyrphostin.A9, mubritinib, CP.724714",0.411168274405793,0.101823516502323,FALSE +"H520","Pearson.est","RAF inhibitor",0.368,0.969,0.456,203,0.986,"dabrafenib, LGX818, vemurafenib, CEP.32496, AZ.628",0.341035157335565,0.0061230850587888,FALSE +"H520","Pearson.est","RET tyrosine kinase inhibitor",0.364,0.962,0.476,24,0.942,"vandetanib",0.322393047279507,0.0259490972071227,FALSE +"H520","Pearson.est","retinoid receptor agonist",-0.6489,-1.58,0.0494,1332,0.336,"bexarotene, adarotene, fenretinide",1.30627305107635,0.473660722610156,FALSE +"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.58793,-1.45,0.0909,859,0.472,"fludarabine, cladribine, fludarabine.phosphate, hydroxyurea, gemcitabine, LY2334737, clofarabine, cytarabine, pentostatin",1.04143611677803,0.326058001365912,FALSE +"H520","Pearson.est","serotonin receptor agonist",-0.6719,-1.69,0.0241,1403,0.281,"zolmitriptan, aripiprazole",1.61798295742513,0.55129368009492,FALSE +"H520","Pearson.est","serotonin receptor antagonist",-0.55509,-1.36,0.138,1306,0.552,"SB.200646, aripiprazole",0.860120913598763,0.258060922270801,FALSE +"H520","Pearson.est","sodium channel blocker",-0.29237,-0.709,0.818,854,0.967,"butamben, cibenzoline, lappaconite, oxcarbazepine, brivaracetam, triamterene, benzethonium",0.087246696328677,0.0145735259169983,FALSE +"H520","Pearson.est","src inhibitor",0.45039,1.22,0.22,112,0.565,"dasatinib, PP.2, saracatinib",0.657577319177794,0.247951552180562,FALSE +"H520","Pearson.est","sterol demethylase inhibitor",-0.34192,-0.842,0.652,1192,0.974,"posaconazole, chlormidazole",0.18575240426808,0.0114410431213845,FALSE +"H520","Pearson.est","TGF beta receptor inhibitor",0.31641,0.85,0.635,246,1,"repsox, LY2109761",0.197226274708024,0,FALSE +"H520","Pearson.est","thymidylate synthase inhibitor",0.61616,1.63,0.0663,322,0.215,"capecitabine, carmofur, ftorafur",1.17848647159523,0.667561540084395,FALSE +"H520","Pearson.est","topoisomerase inhibitor",-0.71823,-1.75,0.00995,1215,0.232,"dexrazoxane, SN.38, genz.644282, doxorubicin, TAS.103, topotecan, teniposide, daunorubicin, nemorubicin, epirubicin, mitoxantrone, amsacrine, voreloxin, etoposide, etoposide.phosphate, valrubicin, amonafide",2.00217691925427,0.6345120151091,TRUE +"H520","Pearson.est","tubulin polymerization inhibitor",-0.58163,-1.43,0.0929,937,0.476,"indibulin, epothilone.b, nocodazole, paclitaxel, vindesine, mebendazole, plinabulin, dolastatin.10, verubulin, parbendazole, flubendazole, CYT.997, vincristine, vinorelbine, fosbretabulin, ABT.751, fenbendazole, combretastatin.A.4, taltobulin, albendazole, KX2.391",1.03198428600636,0.322393047279507,FALSE +"H520","Pearson.est","tyrosine kinase inhibitor",0.26214,0.69,0.859,24,1,"dasatinib, vandetanib",0.0660068361687577,0,FALSE +"H520","Pearson.est","VEGFR inhibitor",-0.28481,-0.713,0.805,1070,1,"axitinib, AEE788, sorafenib, vatalanib, dovitinib, linifanib, OSI.930, ENMD.2076, lenvatinib, regorafenib, pazopanib, nintedanib",0.0942041196321315,0,FALSE +"H520","Pearson.est","vitamin D receptor agonist",-0.42643,-1.06,0.389,957,0.791,"maxacalcitol, doxercalciferol, calcitriol",0.410050398674292,0.101823516502323,FALSE +"H460","Pearson.est","EGFR inhibitor",0.66977,1.97,0.00714,148,0.223,"AZD8931, canertinib, BMS.690514, poziotinib, tucatinib, XL.647, lapatinib, neratinib, gefitinib, osimertinib, dacomitinib, PD.168393, afatinib, icotinib, erlotinib, vandetanib, tyrphostin.AG.494, ARRY.334543, pelitinib, brigatinib",2.14630178822383,0.651695136951839,TRUE +"H460","Pearson.est","Abl kinase inhibitor",-0.27007,-0.657,0.882,852,1,"bosutinib, metatinib, GZD824, flumatinib, tozasertib, nilotinib, KW.2449",0.0545314148681803,0,FALSE +"H460","Pearson.est","acetylcholine receptor agonist",-0.38353,-0.931,0.577,603,0.921,"pilocarpine, nicotine, xanomeline, tremorine, oxiracetam",0.238824186844269,0.0357403698031511,FALSE +"H460","Pearson.est","acetylcholine receptor antagonist",0.30879,0.919,0.582,191,0.949,"darifenacin, iododexetimide",0.235077015350112,0.0227337875727074,FALSE +"H460","Pearson.est","adenosine receptor antagonist",0.38977,1.18,0.232,65,0.745,"CGS.15943, MRS.1220",0.6345120151091,0.127843727251707,FALSE +"H460","Pearson.est","adrenergic receptor agonist",-0.23025,-0.564,0.953,1019,1,"midodrine, buphenine, norepinephrine, clenbuterol",0.0209070993616736,0,FALSE +"H460","Pearson.est","adrenergic receptor antagonist",-0.45597,-1.09,0.355,1122,0.689,"idazoxan, oxprenolol, imiloxan, atipamezole, carvedilol, vincamine",0.449771646944906,0.161780778092374,FALSE +"H460","Pearson.est","AKT inhibitor",0.34694,0.992,0.428,94,0.842,"GDC.0068, GSK2110183, MK.2206",0.368556230986828,0.0746879085003505,FALSE +"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.24846,0.744,0.75,5,0.97,"GW.788388",0.1249387366083,0.0132282657337552,FALSE +"H460","Pearson.est","androgen receptor antagonist",-0.45317,-1.11,0.339,829,0.662,"RU.58841, cyproterone.acetate, nilutamide",0.469800301796918,0.1791420105603,FALSE +"H460","Pearson.est","antioxidant",-0.626,-1.52,0.0438,970,0.314,"trolox, rutin, chlorogenic.acid, mesna, taurine",1.3585258894959,0.503070351926785,FALSE +"H460","Pearson.est","AP inhibitor",-0.35833,-0.867,0.643,523,0.941,"tanshinone.i, idronoxil, GDC.0152, birinapant, LCL.161",0.191789027075778,0.0264103765727431,FALSE +"H460","Pearson.est","ATPase inhibitor",-0.49737,-1.24,0.199,737,0.493,"thonzonium, ouabain, rabeprazole, blebbistatin...., NMS.873, oligomycin.a, evodiamine, digitoxigenin, digitoxin, digoxin",0.701146923590293,0.30715308072277,FALSE +"H460","Pearson.est","Aurora kinase inhibitor",-0.71095,-1.7,0.0151,1115,0.153,"CCT129202, PHA.680632, tozasertib, ZM.447439, barasertib.HQPA, alisertib, KW.2449, MLN.8054, MK.8745, barasertib, CCT137690, danusertib, ENMD.2076, MK.5108, AT.9283, AMG900, SNS.314, hesperadin, PF.03814735",1.82102305270683,0.815308569182401,TRUE +"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.374,-0.901,0.597,1155,0.941,"radezolid, valnemulin",0.224025668870631,0.0264103765727431,FALSE +"H460","Pearson.est","bacterial DNA gyrase inhibitor",-0.33707,-0.813,0.738,1370,0.935,"finafloxacin",0.131943638176958,0.0291883891274822,FALSE +"H460","Pearson.est","BCL inhibitor",-0.48225,-1.18,0.253,1114,0.564,"venetoclax, gossypol, TW.37",0.596879478824182,0.248720896016658,FALSE +"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.29297,-0.71,0.832,762,0.985,"ponatinib, bosutinib, metatinib, GZD824, flumatinib, tozasertib, nilotinib",0.0798766737092761,0.00656376950238827,FALSE +"H460","Pearson.est","benzodiazepine receptor agonist",0.28436,0.798,0.684,129,0.936,"CL.218872, indiplon, piperazine",0.164943898279884,0.0287241512618947,FALSE +"H460","Pearson.est","bromodomain inhibitor",-0.45897,-1.12,0.315,681,0.659,"OTX015, JQ1...., I.BET.762, PFI.1, bromosporine",0.501689446210399,0.18111458540599,FALSE +"H460","Pearson.est","calcium channel blocker",-0.21667,-0.526,0.967,633,1,"penfluridol, pranidipine, SR.33805, cinnarazine, tetrandrine, mibefradil, carboxyamidotriazole",0.0145735259169983,0,FALSE +"H460","Pearson.est","CC chemokine receptor antagonist",-0.46912,-1.13,0.297,676,0.657,"RS.504393, UNBS.5162, PF.04136309, ZK811752, MK.0812, SB.225002, navarixin",0.527243550682788,0.182434630440219,FALSE +"H460","Pearson.est","CDK inhibitor",-0.56059,-1.37,0.1,869,0.353,"arcyriaflavin.a, dinaciclib, CR8..R., PHA.848125, aminopurvalanol.a, BMS.387032, JNJ.7706621, PHA.793887, alvocidib, kenpaullone, NU6027, TG.02, AZD5438, R547, BMS.265246, ribociclib, palbociclib, abemaciclib",1,0.452225294612177,FALSE +"H460","Pearson.est","CHK inhibitor",-0.26895,-0.652,0.89,1199,0.992,"SB.218078",0.0506099933550872,0.00348832784582135,FALSE +"H460","Pearson.est","cyclooxygenase inhibitor",-0.3881,-0.935,0.561,1132,0.937,"piroxicam, suxibuzone, ketoprofen, tepoxalin, FR.122047, indoprofen",0.251037138743839,0.0282604091122217,FALSE +"H460","Pearson.est","cytochrome P450 inhibitor",0.36711,1.15,0.25,919,0.57,"metyrapone, PF.4981517, eplerenone, morin, clotrimazole, itraconazole, cobicistat",0.602059991327962,0.244125144327509,FALSE +"H460","Pearson.est","DNA alkylating agent",-0.62009,-1.49,0.051,1046,0.338,"streptozotocin, TH.302, carboplatin, carmustine, satraplatin, dianhydrogalactitol, melphalan, mitomycin.c",1.29242982390206,0.471083299722345,FALSE +"H460","Pearson.est","DNA inhibitor",-0.51302,-1.23,0.191,931,0.493,"tirapazamine, pibenzimol, mechlorethamine, primaquine, chlorambucil, carboplatin, carmustine, valrubicin, teroxirone, oxaliplatin, melphalan",0.718966632752272,0.30715308072277,FALSE +"H460","Pearson.est","DNA methyltransferase inhibitor",0.29334,0.894,0.583,1025,0.928,"SGI.1027, azacitidine, fdcyd, disulfiram, RG108, decitabine",0.234331445240986,0.0324520237811379,FALSE +"H460","Pearson.est","DNA polymerase inhibitor",-0.5996,-1.44,0.0673,1233,0.415,"foscarnet, trifluridine, idoxuridine",1.17198493577602,0.381951903287907,FALSE +"H460","Pearson.est","DNA synthesis inhibitor",-0.52475,-1.26,0.2,1277,0.467,"enocitabine, floxuridine, cyclocytidine, anisomycin, mitomycin.c",0.698970004336019,0.330683119433888,FALSE +"H460","Pearson.est","dopamine receptor antagonist",-0.34803,-0.837,0.681,793,0.953,"acetophenazine, thioproperazine, amisulpride, remoxipride, mesoridazine, isofloxythepin, sertindole, domperidone, oxiperomide, piperacetazine, raclopride, paliperidone, UH.232....",0.166852888087215,0.0209070993616736,FALSE +"H460","Pearson.est","estrogen receptor agonist",0.3919,1.22,0.241,104,0.751,"levonorgestrel, ethinyl.estradiol, erteberel, equol",0.617982957425132,0.124360062995832,FALSE +"H460","Pearson.est","estrogen receptor antagonist",0.38053,1.16,0.238,260,0.613,"toremifene, tamoxifen, raloxifene, danazol",0.623423042943488,0.212539525481585,FALSE +"H460","Pearson.est","FGFR inhibitor",-0.26343,-0.628,0.921,582,0.994,"orantinib, PD.173074, nintedanib, MK.2461, dovitinib, regorafenib",0.0357403698031511,0.00261361560268669,FALSE +"H460","Pearson.est","FLT3 inhibitor",-0.55936,-1.36,0.114,1014,0.336,"dovitinib, pacritinib, midostaurin, TG.101348, lestaurtinib, tozasertib, sunitinib, KW.2449, TG.02, ENMD.2076, quizartinib",0.943095148663527,0.473660722610156,FALSE +"H460","Pearson.est","glucocorticoid receptor agonist",0.21293,0.656,0.905,1145,1,"piretanide, triamcinolone.acetonide, dexamethasone.acetate, betamethasone, clobetasol.propionate, fludroxycortide, difluprednate, methylprednisolone, prednisolone.hemisuccinate, prednisolone.acetate, deflazacort, hydrocortisone, desonide, triamcinolone, flumethasone.pivalate, fluocinolone.acetonide, halcinonide, fluorometholone, ciclesonide, fluticasone.propionate, halobetasol.propionate, flumethasone, prednisolone, beclomethasone.dipropionate, rimexolone",0.0433514207947967,0,FALSE +"H460","Pearson.est","glutamate receptor antagonist",-0.19301,-0.467,0.987,1303,1,"ACDPP",0.00568284733036327,0,FALSE +"H460","Pearson.est","glycogen synthase kinase inhibitor",0.16817,0.494,0.985,1206,0.984,"CHIR.98014, CHIR.99021, LY2090314, AZD2858, indirubin, GSK.3.inhibitor.IX, TWS.119, tideglusib, kenpaullone",0.00656376950238827,0.00700490156865849,FALSE +"H460","Pearson.est","growth factor receptor inhibitor",-0.57027,-1.38,0.1,1138,0.374,"lestaurtinib, GSK1838705A, danusertib, AZD3463",1,0.42712839779952,FALSE +"H460","Pearson.est","HCV inhibitor",-0.67933,-1.62,0.0129,1332,0.203,"narlaprevir, mericitabine",1.88941028970075,0.692503962086787,TRUE +"H460","Pearson.est","HDAC inhibitor",-0.34307,-0.837,0.656,897,0.953,"R306465, belinostat, resminostat, scriptaid, AR.42, trichostatin.a, PCI.24781, RG2833, entinostat, givinostat, dacinostat, SB.939",0.18309616062434,0.0209070993616736,FALSE +"H460","Pearson.est","histamine receptor antagonist",-0.2111,-0.512,0.966,1345,1,"pheniramine, tiotidine",0.0150228735845067,0,FALSE +"H460","Pearson.est","HMGCR inhibitor",0.46879,1.35,0.136,772,0.571,"lovastatin, pitavastatin, simvastatin, fluvastatin, atorvastatin, mevastatin",0.866461091629782,0.243363891754152,FALSE +"H460","Pearson.est","HSP inhibitor",-0.50421,-1.21,0.229,1272,0.518,"SNX.2112, ganetespib, NVP.AUY922, PU.H71, tanespimycin",0.640164517660112,0.285670240254767,FALSE +"H460","Pearson.est","JAK inhibitor",-0.53356,-1.27,0.18,1050,0.467,"TG.101209, PRT062070, pacritinib, TG.101348, WHI.P154, lestaurtinib, tozasertib, AZ960, TG.02, filgotinib, AT.9283",0.744727494896694,0.330683119433888,FALSE +"H460","Pearson.est","KIT inhibitor",-0.36422,-0.884,0.624,1078,0.953,"OSI.930, midostaurin, sunitinib, regorafenib, vatalanib, KI.8751",0.204815410317576,0.0209070993616736,FALSE +"H460","Pearson.est","MDM inhibitor",-0.74823,-1.83,0.0071,1217,0.227,"RITA, idasanutlin, CGM097, nutlin.3, serdemetan",2.14874165128092,0.643974142806877,TRUE +"H460","Pearson.est","MEK inhibitor",-0.54398,-1.31,0.143,1110,0.408,"MEK162, AS.703026, AZD8330, PD.0325901, PD.198306, selumetinib, arctigenin, TAK.733, PD.318088, Ro.4987655, PD.184352, nobiletin",0.844663962534938,0.38933983691012,FALSE +"H460","Pearson.est","MET inhibitor",0.45839,1.4,0.126,787,0.574,"INC.280, NVP.BVU972, PF.04217903, AMG458, LY2801653, PHA.665752",0.899629454882437,0.241088107602027,FALSE +"H460","Pearson.est","microtubule inhibitor",-0.73347,-1.78,0.00473,1255,0.0942,"cabazitaxel, secnidazole, podophyllotoxin, D.64131, vinflunine, vinblastine",2.32513885926219,1.02594909720712,TRUE +"H460","Pearson.est","mTOR inhibitor",-0.36299,-0.877,0.623,663,0.944,"torin.2, palomid.529, sirolimus, PI.103, voxtalisib, SB.2343, LY303511, WAY.600, PKI.179, AZD2014, AZD8055, NVP.BEZ235, PP242, XL388, deforolimus, torin.1, MLN0128, WYE.354, ku.0063794",0.20551195334083,0.025028005701931,FALSE +"H460","Pearson.est","NFkB pathway inhibitor",0.28691,0.848,0.625,1036,0.895,"bindarit, parthenolide...., tyloxapol, curcumin, BAY.11.7085, IKK.2.inhibitor.V, BAY.11.7082, bortezomib, Ro.106.9920, parthenolide, betulinic.acid, EVP4593",0.204119982655925,0.048176964684088,FALSE +"H460","Pearson.est","opioid receptor agonist",-0.64839,-1.57,0.0301,1097,0.253,"cebranopadol, spiradoline, salvinorin.a, trimebutine",1.52143350440616,0.596879478824182,FALSE +"H460","Pearson.est","p38 MAPK inhibitor",0.37266,1.16,0.271,911,0.613,"talmapimod, TAK.715, VX.702, SB.239063, CMPD.1, SB.242235, skepinone.l",0.567030709125594,0.212539525481585,FALSE +"H460","Pearson.est","PARP inhibitor",-0.74241,-1.8,0.00703,1101,0.106,"AG.14361, niraparib, PJ.34, olaparib, E7449, AZD2461, talazoparib",2.15304467498018,0.97469413473523,TRUE +"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.32057,-0.768,0.783,948,0.965,"CP.673451, axitinib, dovitinib, trapidil, SU014813, sunitinib, regorafenib, vatalanib, crenolanib, KI.8751",0.106238237942057,0.0154726866562074,FALSE +"H460","Pearson.est","phosphatase inhibitor",-0.18902,-0.455,0.993,1107,0.99,"bis.maltolato.oxovanadium.IV., GSK2830371",0.00305075150461883,0.00436480540245009,FALSE +"H460","Pearson.est","phosphodiesterase inhibitor",-0.29501,-0.715,0.823,778,0.998,"anagrelide, YM.976, zardaverine, EMD.53998, GSK256066",0.0846001647877302,0.000869458712628891,FALSE +"H460","Pearson.est","PI3K inhibitor",0.21516,0.645,0.876,138,0.99,"TG100.115, taselisib, alpelisib, buparlisib, PI3K.IN.2, PI.828, pilaralisib",0.0574958938319193,0.00436480540245009,FALSE +"H460","Pearson.est","PLK inhibitor",-0.75573,-1.82,0.00117,1089,0.124,"GW.843682X, NMS.1286937, BI.2536, GSK461364, HMN.214, rigosertib, volasertib",2.93181413825384,0.906578314837765,TRUE +"H460","Pearson.est","potassium channel blocker",-0.42649,-1.03,0.443,615,0.787,"mepivacaine, dofetilide, meglitinide, oleoylethanolamide, ibutilide, ML133",0.35359627377693,0.104025267640935,FALSE +"H460","Pearson.est","PPAR receptor agonist",-0.39634,-0.954,0.549,934,0.919,"oleoylethanolamide, clofibrate, ciprofibrate, GW.501516",0.260427655549908,0.0366844886138887,FALSE +"H460","Pearson.est","progesterone receptor agonist",-0.33588,-0.819,0.728,1159,0.945,"tanaproget, dienogest",0.137868620686963,0.0245681914907371,FALSE +"H460","Pearson.est","proteasome inhibitor",0.29167,0.867,0.59,1028,0.922,"delanzomib, ONX.0914, carfilzomib, oprozomib, ixazomib.citrate, bortezomib, MG.132, ixazomib",0.229147988357856,0.0352690789463706,FALSE +"H460","Pearson.est","protein synthesis inhibitor",-0.58105,-1.43,0.093,1265,0.404,"emetine, cycloheximide, mercaptopurine, harringtonine, bruceantin, anguidine, homoharringtonine",1.03151705144606,0.393618634889395,FALSE +"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.43293,-1.04,0.417,952,0.787,"tyrphostin.A9, mubritinib, NVP.TAE226",0.379863945026242,0.104025267640935,FALSE +"H460","Pearson.est","RAF inhibitor",-0.58609,-1.42,0.0886,899,0.394,"CEP.32496, SB.590885, vemurafenib, PLX.4720, TAK.632, AZ.628, regorafenib, LGX818, RAF265, dabrafenib, GDC.0879",1.05256627811295,0.404503778174426,FALSE +"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.37626,-0.915,0.574,1007,0.933,"cabozantinib, sunitinib, regorafenib",0.241088107602027,0.0301183562535,FALSE +"H460","Pearson.est","retinoid receptor agonist",-0.32481,-0.79,0.751,1381,0.95,"adarotene",0.124360062995832,0.0222763947111523,FALSE +"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.57427,-1.39,0.0957,1051,0.403,"fludarabine, gemcitabine, triapine, cladribine, LY2334737, clofarabine",1.01908806222316,0.39469495385889,FALSE +"H460","Pearson.est","serotonin receptor agonist",-0.58604,-1.4,0.095,1447,0.408,"aripiprazole",1.02227639471115,0.38933983691012,FALSE +"H460","Pearson.est","serotonin receptor antagonist",-0.57541,-1.38,0.087,1374,0.374,"paliperidone, SB.200646, aripiprazole",1.06048074738138,0.42712839779952,FALSE +"H460","Pearson.est","sodium channel blocker",-0.41985,-1.02,0.441,867,0.788,"quinidine, butamben, mexiletine, ajmaline, benzethonium, A.803467, triamterene",0.355561410532161,0.103473782510445,FALSE +"H460","Pearson.est","src inhibitor",0.47523,1.43,0.0867,117,0.678,"saracatinib, dasatinib, ZM.306416, PP.1",1.06198090252379,0.168770306132937,FALSE +"H460","Pearson.est","sterol demethylase inhibitor",-0.33845,-0.827,0.711,751,0.95,"lanoconazole, chlormidazole, ketoconazole",0.148130399270234,0.0222763947111523,FALSE +"H460","Pearson.est","TGF beta receptor inhibitor",0.52966,1.6,0.0494,213,0.553,"LY2109761, repsox, D.4476, SB.431542",1.30627305107635,0.257274868695302,FALSE +"H460","Pearson.est","thymidylate synthase inhibitor",-0.55687,-1.36,0.105,803,0.336,"capecitabine, ftorafur, doxifluridine, trifluridine, carmofur, raltitrexed",0.978810700930062,0.473660722610156,FALSE +"H460","Pearson.est","topoisomerase inhibitor",-0.56549,-1.37,0.105,1070,0.353,"irinotecan, mitoxantrone, doxorubicin, topotecan, rubitecan, dexrazoxane, genz.644282, valrubicin, nemorubicin, daunorubicin, voreloxin, idarubicin, teniposide, amsacrine, amonafide, TAS.103",0.978810700930062,0.452225294612177,FALSE +"H460","Pearson.est","tubulin polymerization inhibitor",-0.67938,-1.66,0.0164,992,0.18,"mebendazole, indibulin, fenbendazole, epothilone.d, paclitaxel, flubendazole, nocodazole, plinabulin, vindesine, vincristine, KX2.391, docetaxel, vinorelbine, podophyllotoxin, CYT.997, ABT.751, parbendazole, dolastatin.10, albendazole, vinblastine, BNC105, epothilone.b, verubulin, combretastatin.A.4, fosbretabulin, taltobulin",1.7851561519523,0.744727494896694,TRUE +"H460","Pearson.est","tyrosine kinase inhibitor",-0.3094,-0.76,0.778,901,0.957,"tivantinib, aminopurvalanol.a, tyrphostin.A9, mubritinib, AMG.208, cabozantinib, sunitinib, regorafenib, NVP.TAE226, UNC2250",0.109020403010311,0.0190880622231565,FALSE +"H460","Pearson.est","VEGFR inhibitor",-0.27627,-0.662,0.885,991,1,"axitinib, cabozantinib, dovitinib, OSI.930, TG.100572, SU014813, sunitinib, regorafenib, SAR131675, vatalanib, ENMD.2076, RAF265, KI.8751",0.0530567293021746,0,FALSE +"H460","Pearson.est","vitamin D receptor agonist",0.20472,0.637,0.917,1153,0.948,"maxacalcitol, calcitriol, alfacalcidol, paricalcitol, tacalcitol, ercalcitriol, doxercalciferol",0.0376306643299789,0.0231916626619338,FALSE +"H1299","Pearson.est","EGFR inhibitor",0.8553,2.37,0,86,0.00903,"AZD8931, poziotinib, XL.647, canertinib, gefitinib, neratinib, lapatinib, dacomitinib, BMS.690514, osimertinib, erlotinib, tucatinib, CUDC.101, afatinib, ARRY.334543, vandetanib, BMS.599626, PD.168393, pelitinib, icotinib, WZ8040, AST.1306, BIBU.1361, PD.153035, CP.724714, AEE788, WZ.4002, rociletinib",Inf,2.04431224968649,TRUE +"H1299","Pearson.est","Abl kinase inhibitor",-0.28354,-0.663,0.881,1087,1,"flumatinib, KW.2449, tozasertib, nilotinib, GZD824",0.0550240915879521,0,FALSE +"H1299","Pearson.est","acetylcholine receptor agonist",-0.45459,-1.06,0.401,1183,0.822,"xanomeline, oxiracetam",0.396855627379818,0.0851281824599496,FALSE +"H1299","Pearson.est","acetylcholine receptor antagonist",-0.50474,-1.19,0.25,1191,0.685,"methscopolamine, iododexetimide",0.602059991327962,0.164309428507574,FALSE +"H1299","Pearson.est","adenosine receptor antagonist",0.63192,1.78,0.0453,130,0.121,"CGS.15943, MRS.1220, SCH.58261, PSB.1115",1.34390179798717,0.91721462968355,TRUE +"H1299","Pearson.est","adrenergic receptor agonist",0.26518,0.722,0.791,1068,0.973,"isoxsuprine, methyldopa, oxymetazoline, isoetharine, ritodrine, norepinephrine, metaraminol, terbutaline, epinephrine, xylazine, A61603, buphenine, clenbuterol, lidamidine, midodrine",0.101823516502323,0.0118871597316481,FALSE +"H1299","Pearson.est","adrenergic receptor antagonist",-0.33515,-0.794,0.741,962,0.986,"metoprolol, pindolol, oxprenolol, atipamezole, vincamine, idazoxan, carvedilol",0.130181792020672,0.0061230850587888,FALSE +"H1299","Pearson.est","AKT inhibitor",0.48453,1.38,0.119,239,0.361,"GDC.0068, uprosertib, CCT128930, GSK2110183, AZD5363, triciribine",0.924453038607469,0.442492798094342,FALSE +"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.29576,0.835,0.679,1023,0.998,"GW.788388, brigatinib, SB.505124, NVP.TAE684, CEP.37440, alectinib, AZD3463, AP26113, crizotinib, DMH1, lorlatinib",0.168130225719498,0.000869458712628891,FALSE +"H1299","Pearson.est","androgen receptor antagonist",-0.34817,-0.829,0.696,592,1,"cyproterone.acetate, RU.58841, bicalutamide, flutamide, nilutamide",0.157390760389438,0,FALSE +"H1299","Pearson.est","antioxidant",0.5215,1.49,0.102,696,0.32,"mesna, taurine, trolox, rutin, chlorogenic.acid, benfotiamine",0.991399828238082,0.494850021680094,FALSE +"H1299","Pearson.est","AP inhibitor",-0.55903,-1.3,0.153,911,0.578,"LCL.161, birinapant, GDC.0152, idronoxil",0.815308569182401,0.238072161579471,FALSE +"H1299","Pearson.est","ATPase inhibitor",-0.69374,-1.62,0.0181,1126,0.227,"evodiamine, k.strophanthidin, digitoxin, ouabain, NMS.873, thonzonium, digitoxigenin, oligomycin.a, digoxin",1.74232142513082,0.643974142806877,TRUE +"H1299","Pearson.est","Aurora kinase inhibitor",-0.6313,-1.47,0.0553,1035,0.368,"TAK.901, aurora.a.inhibitor.i, GSK1070916, alisertib, ZM.447439, KW.2449, tozasertib, barasertib.HQPA, CCT137690, hesperadin, MK.8745, AT.9283, barasertib, PF.03814735, AMG900, danusertib, MK.5108, SNS.314",1.2572748686953,0.434152181326482,FALSE +"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.30898,-0.73,0.817,985,0.996,"josamycin, radezolid, valnemulin",0.0877779434675845,0.00174066157630127,FALSE +"H1299","Pearson.est","bacterial DNA gyrase inhibitor",-0.33572,-0.795,0.716,727,1,"sparfloxacin, sarafloxacin, trovafloxacin, norfloxacin, novobiocin, lomefloxacin",0.145086977692144,0,FALSE +"H1299","Pearson.est","BCL inhibitor",-0.40199,-0.939,0.553,1142,0.9,"gossypol, TW.37",0.257274868695302,0.0457574905606751,FALSE +"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.33095,-0.767,0.779,787,0.986,"metatinib, bafetinib, ponatinib, flumatinib, tozasertib, nilotinib, GZD824",0.108462542327436,0.0061230850587888,FALSE +"H1299","Pearson.est","benzodiazepine receptor agonist",0.28502,0.8,0.7,1039,1,"CL.218872, gamma.aminobutyric.acid, piperazine, nefiracetam, eprinomectin, lorazepam, bentazepam, zaleplon, CGS.20625, indiplon, ZK.93423, temazepam, ivermectin",0.154901959985743,0,FALSE +"H1299","Pearson.est","bromodomain inhibitor",-0.40445,-0.95,0.55,610,0.902,"I.BET151, OTX015, PFI.1, bromosporine",0.259637310505756,0.0447934624580583,FALSE +"H1299","Pearson.est","calcium channel blocker",-0.36853,-0.876,0.641,938,0.958,"pranidipine, SR.33805, penfluridol, carboxyamidotriazole",0.193141970481183,0.0186344909214556,FALSE +"H1299","Pearson.est","CC chemokine receptor antagonist",-0.59519,-1.37,0.111,912,0.545,"RS.504393, PF.04136309, MK.0812, SB.225002, UNBS.5162",0.954677021213343,0.263603497723358,FALSE +"H1299","Pearson.est","CDK inhibitor",-0.28394,-0.666,0.875,815,1,"JNJ.7706621, AZD5438, palbociclib, kenpaullone, PHA.848125, dinaciclib, R547, BMS.387032, indisulam, BMS.265246, abemaciclib, PHA.793887",0.0579919469776868,0,FALSE +"H1299","Pearson.est","CHK inhibitor",-0.42873,-1.01,0.469,1184,0.839,"LY2606368, PF.477736",0.328827157284917,0.0762380391712997,FALSE +"H1299","Pearson.est","cyclooxygenase inhibitor",-0.32707,-0.757,0.817,849,0.98,"metoxibutropate, sulfasalazine, FR.122047, ketoprofen, indoprofen, piroxicam, naproxen, AM.404, suxibuzone, tepoxalin",0.0877779434675845,0.00877392430750515,FALSE +"H1299","Pearson.est","cytochrome P450 inhibitor",-0.47519,-1.11,0.339,1016,0.752,"clotrimazole, cobicistat, metyrapone",0.469800301796918,0.123782159408358,FALSE +"H1299","Pearson.est","DNA alkylating agent",-0.44138,-1.04,0.438,1157,0.818,"TH.302, satraplatin, carboplatin, cisplatin, dianhydrogalactitol, melphalan",0.3585258894959,0.087246696328677,FALSE +"H1299","Pearson.est","DNA inhibitor",-0.40894,-0.978,0.51,954,0.888,"teroxirone, tirapazamine, pibenzimol, carboplatin, valrubicin, melphalan, chlorambucil",0.292429823902064,0.051587034221399,FALSE +"H1299","Pearson.est","DNA methyltransferase inhibitor",0.32605,0.927,0.517,170,0.925,"azacitidine, fdcyd",0.286509456906058,0.0338582672609674,FALSE +"H1299","Pearson.est","DNA polymerase inhibitor",-0.38664,-0.906,0.584,737,0.92,"foscarnet, menadione, adefovir.dipivoxil, trifluridine, idoxuridine, cephalomannine",0.233587152887601,0.0362121726544447,FALSE +"H1299","Pearson.est","DNA synthesis inhibitor",-0.54103,-1.29,0.149,1065,0.569,"azodicarbonamide, cyclocytidine, enocitabine, artesunate, CB.10.277, cisplatin, anisomycin, artemisinin",0.826813731587726,0.244887733604929,FALSE +"H1299","Pearson.est","dopamine receptor antagonist",0.20958,0.571,0.941,229,0.997,"lurasidone, clebopride, ziprasidone, domperidone, mesoridazine, remoxipride, acetophenazine",0.0264103765727431,0.00130484168834428,FALSE +"H1299","Pearson.est","estrogen receptor agonist",0.27778,0.785,0.665,1048,0.922,"erteberel, levonorgestrel, ethinyl.estradiol, equol, estradiol.cypionate, PPT, estrone, estradiol",0.177178354696895,0.0352690789463706,FALSE +"H1299","Pearson.est","estrogen receptor antagonist",-0.34811,-0.825,0.698,1112,1,"fulvestrant, toremifene",0.156144577376839,0,FALSE +"H1299","Pearson.est","FGFR inhibitor",-0.48127,-1.13,0.32,1050,0.727,"MK.2461, dovitinib, nintedanib, erdafitinib, regorafenib",0.494850021680094,0.138465589140962,FALSE +"H1299","Pearson.est","FLT3 inhibitor",-0.49651,-1.16,0.299,1043,0.705,"lestaurtinib, dovitinib, TG.101348, KW.2449, tozasertib, tyrphostin.AG.1296, midostaurin, quizartinib, sorafenib",0.52432881167557,0.151810883008601,FALSE +"H1299","Pearson.est","glucocorticoid receptor agonist",0.22069,0.6,0.94,343,1,"triamcinolone.acetonide, hydrocortisone, ciclesonide, fludroxycortide, desonide, methylprednisolone, betamethasone, fluocinolone.acetonide, flumethasone, flumethasone.pivalate, difluprednate, dexamethasone.acetate, clobetasol.propionate",0.0268721464003014,0,FALSE +"H1299","Pearson.est","glutamate receptor antagonist",0.37983,1.07,0.368,188,0.732,"diazooxonorleucine, latrepirdine, CGP.37849, kynurenic.acid, SIB.1757",0.434152181326482,0.135488918941608,FALSE +"H1299","Pearson.est","glycogen synthase kinase inhibitor",-0.26609,-0.615,0.915,908,0.969,"kenpaullone, TWS.119, GSK.3.inhibitor.IX, AZD2858, tideglusib",0.0385789059335517,0.0136762229492347,FALSE +"H1299","Pearson.est","growth factor receptor inhibitor",-0.38734,-0.914,0.589,914,0.928,"GSK1838705A, PHA.848125, lestaurtinib, danusertib",0.229884705212898,0.0324520237811379,FALSE +"H1299","Pearson.est","HCV inhibitor",-0.65863,-1.55,0.0227,1133,0.321,"Ro.9187, mericitabine, narlaprevir",1.64397414280688,0.493494967595128,FALSE +"H1299","Pearson.est","HDAC inhibitor",-0.29847,-0.701,0.859,660,1,"nexturastat.a, NSC.3852, M.344, R306465, ACY.1215, SB.939, trichostatin.a, resminostat, givinostat, AR.42, RG2833, scriptaid, dacinostat, chidamide, entinostat, belinostat",0.0660068361687577,0,FALSE +"H1299","Pearson.est","histamine receptor antagonist",-0.25626,-0.603,0.928,1121,0.945,"ICI.162846, nizatidine, cimetidine, tiotidine",0.0324520237811379,0.0245681914907371,FALSE +"H1299","Pearson.est","HMGCR inhibitor",-0.85383,-2.03,0,1420,0.0101,"mevastatin, pitavastatin, fluvastatin, atorvastatin",Inf,1.99567862621736,TRUE +"H1299","Pearson.est","HSP inhibitor",-0.63124,-1.5,0.0486,1241,0.386,"BIIB021, PU.H71, ganetespib, SNX.2112, NVP.AUY922, NMS.E973",1.31336373073771,0.413412695328245,FALSE +"H1299","Pearson.est","JAK inhibitor",-0.34295,-0.803,0.737,1043,1,"lestaurtinib, AZ960, TG.101348, tozasertib, PRT062070, AT.9283",0.132532512140949,0,FALSE +"H1299","Pearson.est","KIT inhibitor",-0.50271,-1.18,0.287,1010,0.681,"telatinib, OSI.930, motesanib, cediranib, vatalanib, midostaurin, KI.8751, sorafenib, pazopanib, regorafenib",0.542118103266008,0.166852888087215,FALSE +"H1299","Pearson.est","MDM inhibitor",-0.24383,-0.574,0.938,1202,0.948,"serdemetan",0.0277971616209356,0.0231916626619338,FALSE +"H1299","Pearson.est","MEK inhibitor",0.65261,1.79,0.0286,189,0.194,"trametinib, AS.703026, selumetinib, cobimetinib, AZD8330, PD.0325901, TAK.733, Ro.4987655, MEK162, MEK1.2.inhibitor, PD.318088, PD.198306",1.54363396687096,0.712198270069774,TRUE +"H1299","Pearson.est","MET inhibitor",-0.26184,-0.613,0.931,946,0.954,"AMG458, PHA.665752, LY2801653",0.0310503190186574,0.0204516252959049,FALSE +"H1299","Pearson.est","microtubule inhibitor",-0.73203,-1.71,0.00765,1274,0.12,"D.64131, podophyllotoxin, secnidazole, cabazitaxel, vinflunine, vinblastine",2.11633856484638,0.920818753952375,TRUE +"H1299","Pearson.est","mTOR inhibitor",0.18822,0.51,0.991,981,0.982,"GSK2126458, GDC.0980, WAY.600, WYE.125132, LY303511, voxtalisib, PP242, XL388, OSI.027, PI.103, PF.04691502, torin.2, SB.2343, WYE.354, everolimus, AZD2014, palomid.529, torin.1, AZD8055, temsirolimus, MLN0128, PF.05212384, ku.0063794, NVP.BEZ235, sirolimus, PKI.179, LY3023414",0.00392634551472468,0.00788851221305034,FALSE +"H1299","Pearson.est","NFkB pathway inhibitor",-0.3243,-0.768,0.758,788,1,"BAY.11.7082, betulinic.acid, bortezomib, parthenolide, IKK.2.inhibitor.V, EVP4593",0.120330794367946,0,FALSE +"H1299","Pearson.est","opioid receptor agonist",-0.41169,-0.954,0.543,828,0.918,"cebranopadol, salvinorin.a, trimebutine, spiradoline",0.265200170411153,0.0371573187987575,FALSE +"H1299","Pearson.est","p38 MAPK inhibitor",0.53019,1.46,0.0933,684,0.301,"SB.239063, talmapimod, SB.242235, TAK.715, skepinone.l, VX.702, CMPD.1",1.0301183562535,0.521433504406157,FALSE +"H1299","Pearson.est","PARP inhibitor",-0.52559,-1.25,0.215,917,0.612,"E7449, AG.14361, olaparib, AZD2461, talazoparib",0.667561540084395,0.213248577854439,FALSE +"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49134,-1.15,0.292,1010,0.703,"telatinib, motesanib, dovitinib, SU014813, nintedanib, trapidil, vatalanib, crenolanib, axitinib, CP.673451, KI.8751, sorafenib, pazopanib, regorafenib",0.534617148551582,0.153044674980176,FALSE +"H1299","Pearson.est","phosphatase inhibitor",-0.43489,-1.02,0.445,1117,0.84,"BVT.948, CID.5458317, GSK2830371, bis.maltolato.oxovanadium.IV.",0.351639989019068,0.0757207139381184,FALSE +"H1299","Pearson.est","phosphodiesterase inhibitor",-0.27589,-0.654,0.889,974,1,"papaverine, zardaverine, YM.976, GSK256066",0.0510982390297863,0,FALSE +"H1299","Pearson.est","PI3K inhibitor",0.37286,1.06,0.365,124,0.692,"alpelisib, taselisib, GSK2126458, CH5132799, PI.828, GDC.0980",0.437707135543525,0.159893905543242,FALSE +"H1299","Pearson.est","PLK inhibitor",-0.78765,-1.84,0.00382,1135,0.054,"GW.843682X, HMN.214, GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib",2.41793663708829,1.26760624017703,TRUE +"H1299","Pearson.est","potassium channel blocker",-0.55774,-1.32,0.133,879,0.602,"ibutilide, meglitinide, mepivacaine, dofetilide",0.876148359032914,0.220403508742175,FALSE +"H1299","Pearson.est","PPAR receptor agonist",-0.44533,-1.05,0.406,839,0.82,"ciprofibrate, clofibrate, GW.501516",0.391473966422806,0.0861861476162833,FALSE +"H1299","Pearson.est","progesterone receptor agonist",-0.26273,-0.618,0.945,895,0.984,"norgestrel, dienogest, norethindrone, tanaproget",0.0245681914907371,0.00700490156865849,FALSE +"H1299","Pearson.est","proteasome inhibitor",-0.53586,-1.24,0.21,878,0.609,"bortezomib, ONX.0914, carfilzomib, delanzomib, MG.132, ixazomib",0.677780705266081,0.215382707367125,FALSE +"H1299","Pearson.est","protein synthesis inhibitor",-0.55341,-1.26,0.17,1176,0.617,"cycloheximide, bruceantin, puromycin, thiostrepton, harringtonine, mercaptopurine, homoharringtonine, anguidine",0.769551078621726,0.209714835966758,FALSE +"H1299","Pearson.est","protein tyrosine kinase inhibitor",0.47486,1.25,0.162,143,0.459,"BMS.599626, AV.412, CP.724714, NVP.TAE226",0.790484985457369,0.338187314462739,FALSE +"H1299","Pearson.est","RAF inhibitor",-0.61097,-1.43,0.0728,1266,0.427,"PLX.4720, TAK.632, RAF265, sorafenib, regorafenib",1.13786862068696,0.369572124974976,FALSE +"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.45603,-1.06,0.395,1351,0.822,"sorafenib, regorafenib",0.40340290437354,0.0851281824599496,FALSE +"H1299","Pearson.est","retinoid receptor agonist",0.3445,0.918,0.557,56,0.878,"CD.437, tamibarotene",0.254144804826271,0.0565054840938974,FALSE +"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.62492,-1.49,0.0442,944,0.364,"fludarabine, hydroxyurea, LY2334737, fludarabine.phosphate, triapine, pentostatin, gemcitabine, cladribine, clofarabine",1.35457773065091,0.438898616350944,FALSE +"H1299","Pearson.est","serotonin receptor agonist",-0.55265,-1.3,0.14,1294,0.578,"pardoprunox, aripiprazole",0.853871964321762,0.238072161579471,FALSE +"H1299","Pearson.est","serotonin receptor antagonist",-0.51825,-1.21,0.251,1320,0.659,"paliperidone, lerisetron, aripiprazole",0.600326278518962,0.18111458540599,FALSE +"H1299","Pearson.est","sodium channel blocker",-0.55743,-1.32,0.133,994,0.602,"butamben, quinidine, mepivacaine, brivaracetam, triamterene, benzethonium, cibenzoline",0.876148359032914,0.220403508742175,FALSE +"H1299","Pearson.est","src inhibitor",0.63965,1.78,0.0415,36,0.121,"saracatinib, dasatinib, ZM.306416",1.38195190328791,0.91721462968355,TRUE +"H1299","Pearson.est","sterol demethylase inhibitor",-0.2768,-0.649,0.882,740,0.992,"lanoconazole, ketoconazole, posaconazole, chlormidazole",0.0545314148681803,0.00348832784582135,FALSE +"H1299","Pearson.est","TGF beta receptor inhibitor",0.494,1.32,0.18,234,0.399,"repsox, LY2109761, SB.431542",0.744727494896694,0.399027104313252,FALSE +"H1299","Pearson.est","thymidylate synthase inhibitor",0.23509,0.611,0.935,1109,1,"carmofur, capecitabine, ftorafur, doxifluridine, raltitrexed, trifluridine",0.0291883891274822,0,FALSE +"H1299","Pearson.est","topoisomerase inhibitor",-0.78678,-1.84,0,1228,0.054,"genz.644282, dexrazoxane, SN.38, amonafide, amsacrine, nemorubicin, valrubicin, irinotecan, idarubicin, voreloxin, mitoxantrone, rubitecan, doxorubicin, TAS.103, epirubicin, etoposide, etoposide.phosphate, daunorubicin, teniposide, topotecan",Inf,1.26760624017703,TRUE +"H1299","Pearson.est","tubulin polymerization inhibitor",-0.75495,-1.78,0.00251,1111,0.0757,"flubendazole, parbendazole, mebendazole, epothilone.b, albendazole, plinabulin, fosbretabulin, epothilone.d, fenbendazole, ABT.751, vinorelbine, dolastatin.10, podophyllotoxin, KX2.391, paclitaxel, CYT.997, docetaxel, combretastatin.A.4, vincristine, vindesine, verubulin, taltobulin, BNC105, vinblastine",2.60032627851896,1.12090412049993,TRUE +"H1299","Pearson.est","tyrosine kinase inhibitor",0.28712,0.794,0.766,69,0.961,"vandetanib, BMS.599626, dasatinib, AV.412, CP.724714",0.115771230367396,0.0172766123314547,FALSE +"H1299","Pearson.est","VEGFR inhibitor",-0.26478,-0.632,0.899,1045,0.99,"OSI.930, MK.2461, motesanib, dovitinib, cediranib, SU014813, SAR131675, nintedanib, vatalanib, tivozanib, axitinib, KI.8751, RAF265, sorafenib, pazopanib, regorafenib",0.0462403082667712,0.00436480540245009,FALSE +"H1299","Pearson.est","vitamin D receptor agonist",0.71111,1.95,0.00476,324,0.132,"maxacalcitol, paricalcitol, tacalcitol, calcitriol, ercalcitriol, alfacalcidol",2.32239304727951,0.87942606879415,TRUE +"HCC44","Pearson.est","EGFR inhibitor",-0.77667,-1.87,0.0105,1319,0.13,"rociletinib, ARRY.334543, TAK.285, BIBU.1361, WZ8040, BMS.690514, vandetanib, CUDC.101, BMS.599626, PD.153035, AST.1306, PD.168393, canertinib, icotinib, osimertinib, lapatinib, neratinib, pelitinib, dacomitinib, afatinib, AZD8931, gefitinib, erlotinib, XL.647, poziotinib",1.97881070093006,0.886056647693163,TRUE +"HCC44","Pearson.est","Abl kinase inhibitor",-0.63537,-1.53,0.0623,1344,0.705,"ZM.306416, bosutinib, dasatinib",1.20551195334083,0.151810883008601,FALSE +"HCC44","Pearson.est","acetylcholine receptor agonist",0.32455,0.834,0.633,980,0.927,"nefiracetam, nicotine, oxiracetam, tremorine, xanomeline, pilocarpine",0.198596289982645,0.0329202658555029,FALSE +"HCC44","Pearson.est","acetylcholine receptor antagonist",0.74645,1.98,0.00484,141,0.0671,"iododexetimide, diphemanil, darifenacin",2.31515463835559,1.17327747983101,TRUE +"HCC44","Pearson.est","adenosine receptor antagonist",-0.44804,-1.09,0.35,1126,0.821,"SCH.58261, PSB.1115, CGS.15943",0.455931955649724,0.0856568428805592,FALSE +"HCC44","Pearson.est","adrenergic receptor agonist",0.21407,0.569,0.942,33,0.969,"xylazine",0.0259490972071227,0.0136762229492347,FALSE +"HCC44","Pearson.est","adrenergic receptor antagonist",0.35932,0.931,0.504,207,0.833,"metoprolol, pindolol, propranolol, oxprenolol, practolol",0.297569463554475,0.0793549985932124,FALSE +"HCC44","Pearson.est","AKT inhibitor",-0.36686,-0.894,0.561,1151,0.945,"uprosertib, AT7867, triciribine",0.251037138743839,0.0245681914907371,FALSE +"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.21412,0.57,0.947,317,0.995,"DMH1, CEP.37440, NVP.TAE684",0.0236500209967266,0.00217691925427455,FALSE +"HCC44","Pearson.est","androgen receptor antagonist",0.43812,1.12,0.304,201,0.712,"flutamide, enzalutamide",0.517126416391246,0.147520006363144,FALSE +"HCC44","Pearson.est","antioxidant",-0.41309,-0.994,0.444,1376,0.915,"mesna",0.35261702988538,0.0385789059335517,FALSE +"HCC44","Pearson.est","AP inhibitor",0.20943,0.541,0.956,1146,0.963,"idronoxil, embelin, GDC.0152, LCL.161, tanshinone.i, birinapant",0.0195421077238999,0.0163737128754655,FALSE +"HCC44","Pearson.est","ATPase inhibitor",0.35126,0.909,0.541,278,0.844,"oligomycin.a, rabeprazole, omeprazole, digoxin",0.266802734893431,0.073657553374345,FALSE +"HCC44","Pearson.est","Aurora kinase inhibitor",-0.31203,-0.766,0.744,879,1,"PF.03814735, CCT129202, PHA.680632, MLN.8054, MK.8745, danusertib, CYC116, hesperadin, ENMD.2076, MK.5108, alisertib, GSK1070916",0.128427064454121,0,FALSE +"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.56313,-1.4,0.127,983,0.44,"radezolid, azalomycin.b, valnemulin, tilmicosin, azithromycin, tedizolid",0.896196279044043,0.356547323513813,FALSE +"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.38464,-0.942,0.538,1305,0.913,"lomefloxacin, finafloxacin",0.269217724333611,0.039529222465701,FALSE +"HCC44","Pearson.est","BCL inhibitor",0.41904,1.09,0.33,77,0.73,"ABT.737, oridonin",0.481486060122112,0.136677139879544,FALSE +"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.61142,-1.51,0.0597,1374,0.447,"bosutinib, dasatinib",1.22402566887063,0.349692476868064,FALSE +"HCC44","Pearson.est","benzodiazepine receptor agonist",0.37599,1,0.442,383,0.801,"indiplon, nefiracetam, bentazepam, temazepam, gamma.aminobutyric.acid, piperazine",0.354577730650908,0.0963674839157623,FALSE +"HCC44","Pearson.est","bromodomain inhibitor",0.66177,1.72,0.0203,144,0.323,"PFI.1, I.BET151",1.69250396208679,0.490797477668897,FALSE +"HCC44","Pearson.est","calcium channel blocker",0.29237,0.752,0.756,216,1,"fendiline, SR.33805, pranidipine",0.121478204498793,0,FALSE +"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.36492,-0.889,0.602,1193,0.922,"RS.504393, navarixin, ZK811752",0.220403508742175,0.0352690789463706,FALSE +"HCC44","Pearson.est","CDK inhibitor",-0.59206,-1.42,0.103,1144,0.441,"BMS.387032, dinaciclib, BMS.265246, P276.00, JNJ.7706621, PHA.848125, aminopurvalanol.a, AT.7519, alvocidib, AZD5438",0.987162775294828,0.355561410532161,FALSE +"HCC44","Pearson.est","CHK inhibitor",-0.61325,-1.52,0.0633,1122,0.595,"LY2606368, SCH.900776, AZD7762, CHIR.124, LY2603618",1.19859628998265,0.22548303427145,FALSE +"HCC44","Pearson.est","cyclooxygenase inhibitor",0.36084,0.942,0.495,211,0.846,"naproxen, sulfasalazine, tepoxalin, pterostilbene, AM.404, metoxibutropate, suxibuzone",0.305394801066431,0.0726296369609765,FALSE +"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.2556,-0.617,0.887,1205,1,"eplerenone, itraconazole",0.0520763801682736,0,FALSE +"HCC44","Pearson.est","DNA alkylating agent",0.23654,0.621,0.891,15,0.979,"dianhydrogalactitol",0.0501222959631252,0.00921730819686218,FALSE +"HCC44","Pearson.est","DNA inhibitor",0.29091,0.758,0.737,169,1,"chlorambucil, pibenzimol, bendamustine",0.132532512140949,0,FALSE +"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.53214,-1.31,0.174,1371,0.481,"azacitidine, decitabine",0.7594507517174,0.317854923626168,FALSE +"HCC44","Pearson.est","DNA polymerase inhibitor",-0.34445,-0.827,0.683,893,0.944,"foscarnet, idoxuridine, trifluridine, cephalomannine, adefovir.dipivoxil, cidofovir",0.165579296318467,0.025028005701931,FALSE +"HCC44","Pearson.est","DNA synthesis inhibitor",0.2788,0.728,0.824,183,0.955,"artemisinin, azodicarbonamide, nelarabine, estramustine.phosphate",0.0840727883028842,0.0199966284162537,FALSE +"HCC44","Pearson.est","dopamine receptor antagonist",-0.23435,-0.572,0.943,982,1,"oxiperomide, domperidone, UH.232...., mesoridazine, clebopride, piperacetazine, acetophenazine",0.0254883072626717,0,FALSE +"HCC44","Pearson.est","estrogen receptor agonist",0.24343,0.632,0.88,177,0.995,"equol, estradiol.cypionate",0.0555173278498314,0.00217691925427455,FALSE +"HCC44","Pearson.est","estrogen receptor antagonist",0.61534,1.6,0.0685,74,0.393,"toremifene, danazol",1.16430942850757,0.405607449624573,FALSE +"HCC44","Pearson.est","FGFR inhibitor",0.61005,1.56,0.0835,302,0.348,"erdafitinib, nintedanib, lenvatinib, dovitinib, regorafenib, orantinib",1.0783135245164,0.458420756053419,FALSE +"HCC44","Pearson.est","FLT3 inhibitor",0.29026,0.721,0.779,218,0.935,"TG.101348, dovitinib, sorafenib, sunitinib",0.108462542327436,0.0291883891274822,FALSE +"HCC44","Pearson.est","glucocorticoid receptor agonist",-0.47051,-1.15,0.31,1019,0.73,"prednisolone.acetate, rimexolone, flumethasone.pivalate, flumethasone, halobetasol.propionate, ciclesonide, dexamethasone.acetate, desonide, methylprednisolone, triamcinolone.acetonide, fluocinolone.acetonide, hydrocortisone",0.508638306165727,0.136677139879544,FALSE +"HCC44","Pearson.est","glutamate receptor antagonist",0.28545,0.728,0.798,371,0.955,"felbamate, IEM1754, MTPG, ACDPP, CPP, LY456236",0.0979971086492706,0.0199966284162537,FALSE +"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.17152,-0.413,0.99,938,1,"kenpaullone, TWS.119, indirubin, LY2090314",0.00436480540245009,0,FALSE +"HCC44","Pearson.est","growth factor receptor inhibitor",-0.4931,-1.19,0.273,973,0.684,"AZD3463, danusertib, GSK1838705A, PHA.848125, GSK1904529A",0.563837352959244,0.164943898279884,FALSE +"HCC44","Pearson.est","HCV inhibitor",0.4741,1.24,0.227,43,0.606,"narlaprevir",0.643974142806877,0.217527375833714,FALSE +"HCC44","Pearson.est","HDAC inhibitor",-0.12509,-0.302,1,178,1,"ACY.1215, scriptaid, mocetinostat, vorinostat, nexturastat.a, RG2833, entinostat, R306465, M.344, SB.939, resminostat, pyroxamide, JNJ.26481585, PCI.24781, RGFP966, chidamide, NSC.3852, dacinostat, trichostatin.a, AR.42, belinostat, tacedinaline, panobinostat, givinostat, romidepsin",0,0,FALSE +"HCC44","Pearson.est","histamine receptor antagonist",-0.29786,-0.717,0.795,1020,1,"zolantidine, pheniramine, astemizole, terfenadine, levocetirizine, ebastine, ranitidine",0.0996328713435297,0,FALSE +"HCC44","Pearson.est","HMGCR inhibitor",0.77078,2.01,0.00726,82,0.0758,"mevastatin, pitavastatin, atorvastatin",2.13906337929991,1.12033079436795,TRUE +"HCC44","Pearson.est","HSP inhibitor",-0.60212,-1.45,0.0864,1228,0.419,"XL888, SNX.2112, ganetespib, PU.H71, NVP.AUY922, SNX.5422, BIIB021",1.06348625752111,0.377785977033705,FALSE +"HCC44","Pearson.est","JAK inhibitor",-0.24363,-0.591,0.934,1136,1,"CEP.33779, baricitinib, WHI.P154, filgotinib",0.0296531237699066,0,FALSE +"HCC44","Pearson.est","KIT inhibitor",0.34529,0.903,0.528,267,0.823,"pazopanib, motesanib, lenvatinib, sorafenib, sunitinib, masitinib, regorafenib, telatinib",0.277366077466188,0.0846001647877302,FALSE +"HCC44","Pearson.est","MDM inhibitor",0.51852,1.35,0.15,443,0.598,"AMG.232, CGM097, serdemetan, nutlin.3, idasanutlin",0.823908740944319,0.223298816011589,FALSE +"HCC44","Pearson.est","MEK inhibitor",-0.76889,-1.89,0.0106,1339,0.213,"PD.184352, PD.318088, cobimetinib, TAK.733, PD.0325901, Ro.4987655, refametinib, selumetinib, AS.703026, AZD8330, trametinib",1.97469413473523,0.671620396561262,TRUE +"HCC44","Pearson.est","MET inhibitor",-0.41253,-1.01,0.449,1090,0.924,"INC.280, LY2801653, PHA.665752, PF.04217903",0.347753658996677,0.0343280287798933,FALSE +"HCC44","Pearson.est","microtubule inhibitor",-0.28214,-0.673,0.875,1068,1,"vinflunine, D.64131, podophyllotoxin, cytochalasin.b, vinblastine",0.0579919469776868,0,FALSE +"HCC44","Pearson.est","mTOR inhibitor",-0.21918,-0.53,0.973,1012,1,"AZD8055, WYE.354, OSI.027, PF.04691502, voxtalisib, XL388, WAY.600, PP242, GSK2126458",0.0118871597316481,0,FALSE +"HCC44","Pearson.est","NFkB pathway inhibitor",-0.23599,-0.567,0.941,1114,1,"betulinic.acid, bortezomib, curcumin, BAY.11.7085",0.0264103765727431,0,FALSE +"HCC44","Pearson.est","opioid receptor agonist",-0.41828,-1.01,0.457,878,0.924,"spiradoline, cebranopadol, ADL5859, trimebutine",0.34008379993015,0.0343280287798933,FALSE +"HCC44","Pearson.est","p38 MAPK inhibitor",-0.35563,-0.879,0.592,810,0.909,"SB.242235, skepinone.l, TAK.715, CMPD.1, SB.239063",0.22767829327708,0.0414361167780325,FALSE +"HCC44","Pearson.est","PARP inhibitor",0.39246,1.02,0.415,249,0.839,"AZD2461, PJ.34, AG.14361",0.381951903287907,0.0762380391712997,FALSE +"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.46181,1.18,0.282,302,0.636,"nintedanib, trapidil, pazopanib, motesanib, lenvatinib, axitinib, dovitinib, sorafenib, sunitinib, masitinib, regorafenib, linifanib, telatinib, orantinib",0.549750891680639,0.196542884351586,FALSE +"HCC44","Pearson.est","phosphatase inhibitor",0.49542,1.26,0.193,337,0.666,"GSK2830371, BVT.948, bis.maltolato.oxovanadium.IV., menadione, CID.5458317, sodium.stibogluconate",0.714442690992226,0.176525770829699,FALSE +"HCC44","Pearson.est","phosphodiesterase inhibitor",-0.3008,-0.716,0.799,1069,1,"cilostamide, zardaverine, EMD.53998, papaverine, YM.976",0.0974532206860086,0,FALSE +"HCC44","Pearson.est","PI3K inhibitor",-0.34926,-0.832,0.664,1022,0.966,"GDC.0941, taselisib, PF.04691502, buparlisib, voxtalisib, CH5132799, AZD6482, GSK2126458, alpelisib, TG.100713",0.177831920631982,0.0150228735845067,FALSE +"HCC44","Pearson.est","PLK inhibitor",-0.61739,-1.47,0.106,927,0.478,"GSK461364, BI.2536, GW.843682X, rigosertib, NMS.1286937",0.97469413473523,0.320572103387881,FALSE +"HCC44","Pearson.est","potassium channel blocker",0.37933,0.977,0.458,901,0.813,"dofetilide, mepivacaine, ibutilide, ML133, meglitinide, oleoylethanolamide",0.339134521996131,0.0899094544059319,FALSE +"HCC44","Pearson.est","PPAR receptor agonist",0.61732,1.59,0.0784,131,0.348,"GW.501516, clofibrate, pterostilbene",1.10568393731556,0.458420756053419,FALSE +"HCC44","Pearson.est","progesterone receptor agonist",0.52195,1.37,0.138,140,0.62,"danazol, norethindrone.acetate, norethindrone",0.860120913598763,0.207608310501746,FALSE +"HCC44","Pearson.est","proteasome inhibitor",0.64055,1.67,0.0554,134,0.346,"delanzomib, oprozomib, MG.132, ONX.0914",1.25649023527157,0.460923901207223,FALSE +"HCC44","Pearson.est","protein synthesis inhibitor",-0.15624,-0.371,0.998,1120,1,"cycloheximide, brefeldin.a, thiostrepton, tedizolid.phosphate",0.000869458712628891,0,FALSE +"HCC44","Pearson.est","protein tyrosine kinase inhibitor",-0.60716,-1.46,0.104,1260,0.443,"PP.121, NVP.TAE226, AV.412, BMS.599626",0.98296666070122,0.35359627377693,FALSE +"HCC44","Pearson.est","RAF inhibitor",0.46046,1.23,0.228,331,0.583,"sorafenib, regorafenib, TAK.632, RAF265, vemurafenib, PLX.4720, dabrafenib",0.642065152999546,0.234331445240986,FALSE +"HCC44","Pearson.est","RET tyrosine kinase inhibitor",-0.39285,-0.954,0.512,1406,0.925,"vandetanib",0.290730039024169,0.0338582672609674,FALSE +"HCC44","Pearson.est","retinoid receptor agonist",0.51703,1.32,0.164,289,0.6,"fenretinide, adapalene, LE.135, bexarotene, adarotene",0.785156151952302,0.221848749616356,FALSE +"HCC44","Pearson.est","ribonucleotide reductase inhibitor",0.48175,1.24,0.203,61,0.606,"pentostatin, cladribine",0.692503962086787,0.217527375833714,FALSE +"HCC44","Pearson.est","serotonin receptor agonist",-0.54996,-1.34,0.153,944,0.489,"pardoprunox, SR.57227A, aripiprazole, ipsapirone",0.815308569182401,0.31069114087638,FALSE +"HCC44","Pearson.est","serotonin receptor antagonist",-0.40432,-0.975,0.493,1164,0.918,"aripiprazole, RS.16566, pirenperone, SB.228357",0.30715308072277,0.0371573187987575,FALSE +"HCC44","Pearson.est","sodium channel blocker",0.39294,1.01,0.425,66,0.82,"oxcarbazepine, cibenzoline, triamterene",0.371611069949688,0.0861861476162833,FALSE +"HCC44","Pearson.est","src inhibitor",-0.69916,-1.69,0.0218,1344,0.365,"ZM.306416, bosutinib, saracatinib, dasatinib",1.6615435063954,0.437707135543525,FALSE +"HCC44","Pearson.est","sterol demethylase inhibitor",0.79065,2.06,0.00477,124,0.0971,"ketoconazole, chlormidazole, lanoconazole, posaconazole",2.32148162095989,1.012780770092,TRUE +"HCC44","Pearson.est","TGF beta receptor inhibitor",0.26929,0.693,0.829,203,0.947,"SB.525334, adaprev",0.0814454694497265,0.0236500209967266,FALSE +"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.57027,-1.34,0.168,1086,0.489,"trifluridine, ftorafur, capecitabine, raltitrexed, carmofur",0.774690718274137,0.31069114087638,FALSE +"HCC44","Pearson.est","topoisomerase inhibitor",-0.38544,-0.94,0.522,1013,0.882,"genz.644282, voreloxin, teniposide, amsacrine, TAS.103, mitoxantrone, rubitecan, licochalcone.a, camptothecin, idarubicin, SN.38, fleroxacin, exatecan.mesylate",0.282329496997738,0.0545314148681803,FALSE +"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.6189,-1.51,0.0775,996,0.447,"oxibendazole, ABT.751, epothilone.d, dolastatin.10, vindesine, plinabulin, BNC105, podophyllotoxin, albendazole, vinblastine, verubulin, fosbretabulin, indibulin, paclitaxel, docetaxel, epothilone.b, parbendazole, nocodazole",1.11069829749369,0.349692476868064,FALSE +"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.55177,-1.33,0.142,1372,0.475,"aminopurvalanol.a, NVP.TAE226, tivantinib, vandetanib, AV.412, BMS.599626, dasatinib",0.847711655616944,0.323306390375133,FALSE +"HCC44","Pearson.est","VEGFR inhibitor",0.2805,0.739,0.774,302,1,"nintedanib, tivozanib, pazopanib, motesanib, lenvatinib, axitinib, dovitinib, sorafenib, sunitinib, regorafenib, linifanib, SAR131675, telatinib, RAF265, orantinib",0.111259039317107,0,FALSE +"HCC44","Pearson.est","vitamin D receptor agonist",-0.24834,-0.595,0.945,872,1,"alfacalcidol, tacalcitol, ercalcitriol",0.0245681914907371,0,FALSE +"A549","Pearson.est","EGFR inhibitor",0.33888,0.978,0.431,150,0.718,"CUDC.101, tucatinib, canertinib, AST.1306, AZD8931, BIBX.1382, lapatinib, neratinib",0.365522729839268,0.1438755557577,FALSE +"A549","Pearson.est","Abl kinase inhibitor",-0.60157,-1.48,0.0814,1088,0.469,"KW.2449, flumatinib, bosutinib, GZD824, metatinib, ponatinib, nilotinib, dasatinib",1.0893755951108,0.328827157284917,FALSE +"A549","Pearson.est","acetylcholine receptor agonist",0.3301,0.945,0.496,972,0.69,"xanomeline, oxiracetam, nefiracetam, tremorine, nicotine, pilocarpine",0.304518323509803,0.161150909262745,FALSE +"A549","Pearson.est","acetylcholine receptor antagonist",-0.30649,-0.751,0.786,1062,0.991,"dicycloverine, methscopolamine",0.104577453960592,0.00392634551472468,FALSE +"A549","Pearson.est","adenosine receptor antagonist",0.35878,0.991,0.412,931,0.739,"MRS.1220, CGS.15943, SCH.58261, istradefylline, sulmazole, PSB.1115, theophylline",0.385102783966865,0.131355561605174,FALSE +"A549","Pearson.est","adrenergic receptor agonist",-0.3005,-0.736,0.805,1238,0.991,"isoetharine, isoxsuprine, buphenine, clenbuterol",0.0942041196321315,0.00392634551472468,FALSE +"A549","Pearson.est","adrenergic receptor antagonist",-0.37354,-0.909,0.582,1092,0.92,"carvedilol, vincamine, dronedarone, imiloxan, levobunolol, atipamezole, pindolol",0.235077015350112,0.0362121726544447,FALSE +"A549","Pearson.est","AKT inhibitor",0.51381,1.45,0.102,80,0.27,"GDC.0068, uprosertib, GSK2110183, MK.2206",0.991399828238082,0.568636235841013,FALSE +"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.33285,-0.831,0.667,1428,0.885,"AZD3463",0.175874166083451,0.0530567293021746,FALSE +"A549","Pearson.est","androgen receptor antagonist",-0.78373,-1.95,0.00137,1411,0.0473,"nilutamide, RU.58841, cyproterone.acetate",2.86327943284359,1.32513885926219,TRUE +"A549","Pearson.est","antioxidant",-0.64661,-1.59,0.0298,1004,0.372,"chlorogenic.acid, taurine, trolox, rutin",1.52578373592374,0.429457060118102,FALSE +"A549","Pearson.est","AP inhibitor",0.40985,1.21,0.236,857,0.494,"embelin, tanshinone.i, birinapant, idronoxil, LCL.161, GDC.0152",0.627087997029893,0.306273051076353,FALSE +"A549","Pearson.est","ATPase inhibitor",-0.65379,-1.61,0.032,1274,0.389,"blebbistatin...., digoxin, digitoxin, ouabain, digitoxigenin",1.49485002168009,0.410050398674292,FALSE +"A549","Pearson.est","Aurora kinase inhibitor",-0.36789,-0.909,0.589,868,0.92,"alisertib, MK.8745, SNS.314, MK.5108, hesperadin, KW.2449, CYC116, MLN.8054, AT.9283, CCT129202, AMG900, PF.03814735",0.229884705212898,0.0362121726544447,FALSE +"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.42893,-1.06,0.402,972,0.803,"tilmicosin, tedizolid, dirithromycin, valnemulin, radezolid",0.39577394691553,0.095284454721319,FALSE +"A549","Pearson.est","bacterial DNA gyrase inhibitor",-0.34546,-0.869,0.638,1362,0.882,"finafloxacin",0.195179321278838,0.0545314148681803,FALSE +"A549","Pearson.est","BCL inhibitor",-0.38822,-0.962,0.507,1072,0.941,"TW.37, navitoclax, gossypol",0.294992040666664,0.0264103765727431,FALSE +"A549","Pearson.est","Bcr.Abl kinase inhibitor",-0.62275,-1.54,0.0637,1138,0.376,"flumatinib, bosutinib, GZD824, metatinib, ponatinib, nilotinib, dasatinib",1.19586056766465,0.424812155072339,FALSE +"A549","Pearson.est","benzodiazepine receptor agonist",-0.2374,-0.582,0.935,1119,0.966,"lorazepam, CGS.20625, ivermectin, eprinomectin",0.0291883891274822,0.0150228735845067,FALSE +"A549","Pearson.est","bromodomain inhibitor",0.77989,2.22,0,248,0.0603,"I.BET151, OTX015, JQ1...., I.BET.762, PFI.1",Inf,1.21968268785985,TRUE +"A549","Pearson.est","calcium channel blocker",0.21198,0.629,0.905,244,0.908,"fendiline, penfluridol",0.0433514207947967,0.0419141514789149,FALSE +"A549","Pearson.est","CC chemokine receptor antagonist",-0.36392,-0.889,0.591,1341,0.911,"navarixin",0.228412519118745,0.0404816230270017,FALSE +"A549","Pearson.est","CDK inhibitor",-0.51895,-1.27,0.192,1283,0.597,"NU6027, kenpaullone, R547, AZD5438, palbociclib, PHA.848125, abemaciclib, BMS.265246",0.71669877129645,0.224025668870631,FALSE +"A549","Pearson.est","CHK inhibitor",0.5306,1.52,0.086,211,0.274,"PF.477736, LY2606368",1.06550154875643,0.562249437179612,FALSE +"A549","Pearson.est","cyclooxygenase inhibitor",-0.23348,-0.588,0.929,908,0.997,"meloxicam, piroxicam, suxibuzone, FR.122047, acetylsalicylsalicylic.acid, tryptanthrin, ketoprofen, indoprofen, tepoxalin",0.0319842860063582,0.00130484168834428,FALSE +"A549","Pearson.est","cytochrome P450 inhibitor",-0.50773,-1.24,0.199,978,0.641,"metyrapone, itraconazole, cobicistat, eplerenone",0.701146923590293,0.193141970481183,FALSE +"A549","Pearson.est","DNA alkylating agent",-0.58601,-1.43,0.0994,1087,0.499,"carmustine, TH.302, melphalan, ifosfamide, carboplatin, dianhydrogalactitol, streptozotocin, mitomycin.c",1.00261361560269,0.30189945437661,FALSE +"A549","Pearson.est","DNA inhibitor",-0.35469,-0.885,0.594,1055,0.896,"nimorazole, carmustine, melphalan, carboplatin, tirapazamine, valrubicin, teroxirone",0.226213555018806,0.0476919903378748,FALSE +"A549","Pearson.est","DNA methyltransferase inhibitor",0.56793,1.6,0.0839,61,0.288,"SGI.1027, azacitidine",1.0762380391713,0.540607512240769,FALSE +"A549","Pearson.est","DNA polymerase inhibitor",0.2253,0.65,0.906,230,0.967,"cephalomannine, cidofovir, menadione",0.0428718023231869,0.0145735259169983,FALSE +"A549","Pearson.est","DNA synthesis inhibitor",-0.56393,-1.41,0.109,1247,0.507,"artesunate, azodicarbonamide, floxuridine, cyclocytidine, anisomycin, mitomycin.c",0.962573502059376,0.294992040666664,FALSE +"A549","Pearson.est","dopamine receptor antagonist",-0.34429,-0.835,0.663,1073,0.899,"amisulpride, nemonapride, piperacetazine, mesoridazine, acetophenazine, remoxipride, UH.232...., raclopride",0.178486471595227,0.0462403082667712,FALSE +"A549","Pearson.est","estrogen receptor agonist",-0.37469,-0.925,0.545,1091,0.94,"estradiol.cypionate, estradiol, estrone",0.263603497723358,0.0268721464003014,FALSE +"A549","Pearson.est","estrogen receptor antagonist",0.65731,1.87,0.0294,273,0.166,"toremifene, clomifene, raloxifene, tamoxifen",1.53165266958784,0.779891911959945,TRUE +"A549","Pearson.est","FGFR inhibitor",-0.26314,-0.638,0.881,970,1,"lucitanib, nintedanib, AZD4547",0.0550240915879521,0,FALSE +"A549","Pearson.est","FLT3 inhibitor",-0.47559,-1.15,0.298,1083,0.734,"TG.101348, KW.2449, GTP.14564, ponatinib, midostaurin, quizartinib",0.525783735923745,0.134303940083929,FALSE +"A549","Pearson.est","glucocorticoid receptor agonist",-0.53713,-1.33,0.151,1146,0.588,"ciclesonide, flumethasone, flumethasone.pivalate, fludroxycortide, deflazacort, desonide, rimexolone, fluticasone.propionate, triamcinolone, prednisolone.acetate, beclomethasone.dipropionate, halobetasol.propionate, fluocinolone.acetonide",0.821023052706831,0.230622673923862,FALSE +"A549","Pearson.est","glutamate receptor antagonist",0.34427,0.942,0.517,95,0.657,"felbamate, CPP, CGP.37849",0.286509456906058,0.182434630440219,FALSE +"A549","Pearson.est","glycogen synthase kinase inhibitor",-0.28529,-0.707,0.797,1300,0.991,"TWS.119, kenpaullone",0.0985416786038876,0.00392634551472468,FALSE +"A549","Pearson.est","growth factor receptor inhibitor",-0.82708,-2.06,0,1415,0.0193,"PHA.848125, AZD3463",Inf,1.71444269099223,TRUE +"A549","Pearson.est","HCV inhibitor",-0.24908,-0.611,0.905,1103,1,"Ro.9187, mericitabine",0.0433514207947967,0,FALSE +"A549","Pearson.est","HDAC inhibitor",0.49376,1.45,0.122,281,0.27,"M.344, tacedinaline, PCI.24781, vorinostat, romidepsin, nexturastat.a, JNJ.26481585, R306465, trichostatin.a, panobinostat, NSC.3852",0.913640169325252,0.568636235841013,FALSE +"A549","Pearson.est","histamine receptor antagonist",-0.17076,-0.424,0.992,965,0.994,"tiotidine, zolantidine, famotidine, terfenadine, pheniramine, BF2.649, nizatidine",0.00348832784582135,0.00261361560268669,FALSE +"A549","Pearson.est","HMGCR inhibitor",0.21845,0.629,0.911,1133,0.908,"simvastatin, pitavastatin, atorvastatin, lovastatin, mevastatin, fluvastatin",0.0404816230270017,0.0419141514789149,FALSE +"A549","Pearson.est","HSP inhibitor",-0.2821,-0.693,0.829,929,0.989,"BIIB021, XL888, PU.H71, NVP.AUY922, SNX.2112, ganetespib, tanespimycin",0.0814454694497265,0.0048037084028206,FALSE +"A549","Pearson.est","JAK inhibitor",-0.45014,-1.11,0.332,1083,0.801,"TG.101348, AT.9283, CEP.33779, WHI.P154, filgotinib, TG.101209, AZ960",0.478861916295964,0.0963674839157623,FALSE +"A549","Pearson.est","KIT inhibitor",-0.3727,-0.927,0.575,1366,0.963,"dasatinib, midostaurin, KI.8751",0.24033215531037,0.0163737128754655,FALSE +"A549","Pearson.est","MDM inhibitor",-0.69487,-1.75,0.00811,1002,0.174,"AMG.232, nutlin.3, serdemetan, CGM097, idasanutlin, RITA",2.09097914578884,0.7594507517174,TRUE +"A549","Pearson.est","MEK inhibitor",0.27388,0.783,0.726,289,0.904,"MEK162, BIX.02188, cobimetinib, AS.703026, MEK1.2.inhibitor, trametinib, PD.98059",0.139063379299906,0.0438315695246367,FALSE +"A549","Pearson.est","MET inhibitor",-0.52257,-1.29,0.17,1173,0.581,"LY2801653, NVP.BVU972, PF.04217903",0.769551078621726,0.235823867609669,FALSE +"A549","Pearson.est","microtubule inhibitor",-0.42385,-1.06,0.378,788,0.803,"vinblastine, cabazitaxel, D.64131, secnidazole, podophyllotoxin, estramustine.phosphate, cytochalasin.b",0.422508200162775,0.095284454721319,FALSE +"A549","Pearson.est","mTOR inhibitor",-0.62381,-1.55,0.0622,1060,0.405,"palomid.529, everolimus, voxtalisib, PKI.179, PI.103, PP242, deforolimus, WYE.125132, XL388, AZD2014, temsirolimus, sirolimus, WAY.600, LY3023414, AZD8055, NVP.BEZ235, ku.0063794, GDC.0980, WYE.354, MLN0128, SB.2343, torin.1",1.20620961530918,0.392544976785331,FALSE +"A549","Pearson.est","NFkB pathway inhibitor",0.50287,1.41,0.109,209,0.283,"parthenolide...., bortezomib, Ro.106.9920, curcumin, tyloxapol, parthenolide",0.962573502059376,0.54821356447571,FALSE +"A549","Pearson.est","opioid receptor agonist",-0.53415,-1.31,0.166,931,0.564,"spiradoline, BW.180C, salvinorin.a, trimebutine, cebranopadol",0.779891911959945,0.248720896016658,FALSE +"A549","Pearson.est","p38 MAPK inhibitor",-0.25429,-0.633,0.898,1194,1,"skepinone.l",0.0467236633326956,0,FALSE +"A549","Pearson.est","PARP inhibitor",-0.44298,-1.1,0.358,1434,0.795,"E7449",0.446116973356126,0.0996328713435297,FALSE +"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.39754,-0.978,0.49,887,0.936,"trapidil, tandutinib, motesanib, vatalanib, linifanib, nintedanib, telatinib, ponatinib, CP.673451, dasatinib, KI.8751, crenolanib",0.309803919971486,0.0287241512618947,FALSE +"A549","Pearson.est","phosphatase inhibitor",-0.24031,-0.592,0.92,1207,1,"GSK2830371, mycophenolic.acid",0.0362121726544447,0,FALSE +"A549","Pearson.est","phosphodiesterase inhibitor",-0.54342,-1.34,0.124,1174,0.601,"anagrelide, GSK256066, zardaverine, YM.976",0.906578314837765,0.22112552799726,FALSE +"A549","Pearson.est","PI3K inhibitor",-0.36035,-0.882,0.615,1022,0.88,"GSK2126458, TG.100713, GDC.0941, voxtalisib, PKI.179, PI.103, BGT226, ZSTK.474, LY3023414, PI3K.IN.2, NVP.BEZ235, GDC.0980, SB.2343",0.211124884224583,0.0555173278498314,FALSE +"A549","Pearson.est","PLK inhibitor",-0.57832,-1.43,0.0989,859,0.499,"BI.2536, HMN.214, rigosertib, GSK461364, GW.843682X, volasertib",1.00480370840282,0.30189945437661,FALSE +"A549","Pearson.est","potassium channel blocker",-0.70541,-1.81,0.00551,1297,0.137,"ML133, ibutilide",2.25884840114822,0.863279432843593,TRUE +"A549","Pearson.est","PPAR receptor agonist",0.33765,0.963,0.513,259,0.699,"pterostilbene, clofibrate",0.289882634888184,0.155522824254319,FALSE +"A549","Pearson.est","progesterone receptor agonist",-0.40909,-1.01,0.466,830,0.89,"norethindrone.acetate, norethindrone, norgestrel, dienogest, melengestrol.acetate, tanaproget",0.33161408331,0.0506099933550872,FALSE +"A549","Pearson.est","proteasome inhibitor",0.59865,1.66,0.037,292,0.282,"carfilzomib, ONX.0914, bortezomib, oprozomib, delanzomib",1.431798275933,0.549750891680639,FALSE +"A549","Pearson.est","protein synthesis inhibitor",-0.3832,-0.934,0.55,1180,0.976,"emetine, cycloheximide, methacycline, mercaptopurine, florfenicol",0.259637310505756,0.0105501823333082,FALSE +"A549","Pearson.est","protein tyrosine kinase inhibitor",-0.29917,-0.733,0.797,1204,0.975,"BMS.599626, mubritinib",0.0985416786038876,0.0109953843014632,FALSE +"A549","Pearson.est","RAF inhibitor",0.55808,1.54,0.0913,328,0.298,"AZ.628, vemurafenib, regorafenib, GDC.0879, TAK.632, dabrafenib, LGX818",1.0395292224657,0.525783735923745,FALSE +"A549","Pearson.est","RET tyrosine kinase inhibitor",0.40707,1.15,0.278,861,0.544,"regorafenib, sorafenib, vandetanib, sunitinib, cabozantinib, apatinib",0.555955204081924,0.26440110030182,FALSE +"A549","Pearson.est","retinoid receptor agonist",0.67559,1.97,0.00791,216,0.156,"fenretinide, adapalene, adarotene, tamibarotene, CD.437, AM.580",2.10182351650232,0.806875401645538,TRUE +"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.46328,-1.15,0.298,1112,0.734,"triapine, cladribine, clofarabine, gemcitabine",0.525783735923745,0.134303940083929,FALSE +"A549","Pearson.est","serotonin receptor agonist",-0.56292,-1.4,0.118,1336,0.493,"ipsapirone, aripiprazole",0.928117992693875,0.30715308072277,FALSE +"A549","Pearson.est","serotonin receptor antagonist",0.23767,0.672,0.871,5,0.986,"lurasidone",0.0599818449923368,0.0061230850587888,FALSE +"A549","Pearson.est","sodium channel blocker",-0.34226,-0.856,0.66,1246,0.884,"ajmaline, A.803467, butamben",0.180456064458131,0.0535477349869269,FALSE +"A549","Pearson.est","src inhibitor",-0.47127,-1.18,0.28,1152,0.724,"bosutinib, KX2.391, dasatinib",0.552841968657781,0.140261433802853,FALSE +"A549","Pearson.est","sterol demethylase inhibitor",-0.48612,-1.19,0.246,994,0.734,"lanoconazole, ketoconazole",0.609064892896621,0.134303940083929,FALSE +"A549","Pearson.est","TGF beta receptor inhibitor",0.38538,1.08,0.309,280,0.623,"LY2109761, D.4476, SB.525334",0.510041520575165,0.20551195334083,FALSE +"A549","Pearson.est","thymidylate synthase inhibitor",-0.42848,-1.06,0.394,720,0.803,"trifluridine, carmofur, capecitabine, ftorafur, raltitrexed",0.404503778174426,0.095284454721319,FALSE +"A549","Pearson.est","topoisomerase inhibitor",-0.53261,-1.32,0.164,1293,0.574,"exatecan.mesylate, valrubicin, amonafide, teniposide, voreloxin, amsacrine, fleroxacin, idarubicin, TAS.103",0.785156151952302,0.241088107602027,FALSE +"A549","Pearson.est","tubulin polymerization inhibitor",-0.36098,-0.892,0.606,780,0.929,"plinabulin, vinblastine, docetaxel, albendazole, dolastatin.10, parbendazole, fenbendazole, podophyllotoxin, ABT.751, BNC105, CYT.997, taltobulin, combretastatin.A.4, verubulin, KX2.391, epothilone.d, epothilone.b",0.217527375833714,0.0319842860063582,FALSE +"A549","Pearson.est","tyrosine kinase inhibitor",-0.23105,-0.562,0.952,1167,0.962,"GTP.14564, BMS.599626, UNC2250, mubritinib, dasatinib",0.0213630516155257,0.0168249279621871,FALSE +"A549","Pearson.est","VEGFR inhibitor",-0.237,-0.587,0.94,683,0.98,"TG.100572, PD.173074, SU014813, SAR131675, ENMD.2076, cabozantinib, tivozanib, foretinib, cediranib, motesanib, vatalanib, RAF265, lucitanib, linifanib, nintedanib, telatinib, MGCD.265, KI.8751",0.0268721464003014,0.00877392430750515,FALSE +"A549","Pearson.est","vitamin D receptor agonist",0.23942,0.68,0.867,1103,1,"maxacalcitol, paricalcitol, calcitriol, doxercalciferol, alfacalcidol, ercalcitriol, tacalcitol",0.0619809025237897,0,FALSE +"H1703","Pearson.est","EGFR inhibitor",0.84369,2.2,0,44,0.0248,"AZD8931, poziotinib, gefitinib, dacomitinib, XL.647, neratinib, canertinib, lapatinib, osimertinib, afatinib, erlotinib, BMS.690514, CUDC.101, BIBU.1361, pelitinib, tucatinib, AST.1306, PD.153035, vandetanib, ARRY.334543, BMS.599626, PD.168393, icotinib, WZ8040",Inf,1.60554831917378,TRUE +"H1703","Pearson.est","Abl kinase inhibitor",0.31258,0.83,0.65,157,0.97,"dasatinib, ZM.306416, bosutinib",0.187086643357144,0.0132282657337552,FALSE +"H1703","Pearson.est","acetylcholine receptor agonist",-0.23569,-0.573,0.941,875,1,"nefiracetam, xanomeline, oxiracetam",0.0264103765727431,0,FALSE +"H1703","Pearson.est","acetylcholine receptor antagonist",-0.51067,-1.23,0.231,1070,0.601,"darifenacin, methscopolamine, iododexetimide",0.636388020107856,0.22112552799726,FALSE +"H1703","Pearson.est","adenosine receptor antagonist",0.61096,1.55,0.103,93,0.434,"CGS.15943, MRS.1220, SCH.58261",0.987162775294828,0.362510270487489,FALSE +"H1703","Pearson.est","adrenergic receptor agonist",-0.15985,-0.385,0.992,791,0.998,"A61603, buphenine, metaraminol, lidamidine, clenbuterol, midodrine, xylazine",0.00348832784582135,0.000869458712628891,FALSE +"H1703","Pearson.est","adrenergic receptor antagonist",-0.25644,-0.625,0.904,931,1,"idazoxan, vincamine, atipamezole, levobunolol, metoprolol, pindolol, carvedilol",0.0438315695246367,0,FALSE +"H1703","Pearson.est","AKT inhibitor",0.4773,1.25,0.206,258,0.901,"uprosertib, triciribine, GDC.0068, AZD5363, MK.2206, GSK2110183, CCT128930",0.686132779630847,0.045275209020937,FALSE +"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.24274,0.664,0.882,352,0.993,"GW.788388, SB.505124, brigatinib, NVP.TAE684, alectinib",0.0545314148681803,0.00305075150461883,FALSE +"H1703","Pearson.est","androgen receptor antagonist",-0.46463,-1.11,0.327,670,0.669,"cyproterone.acetate, enzalutamide, bicalutamide, RU.58841, nilutamide, flutamide",0.485452247339714,0.174573882232177,FALSE +"H1703","Pearson.est","antioxidant",0.38276,1.02,0.405,60,0.769,"mesna",0.392544976785331,0.114073660198569,FALSE +"H1703","Pearson.est","AP inhibitor",-0.53653,-1.29,0.181,907,0.59,"LCL.161, birinapant, GDC.0152, idronoxil",0.742321425130815,0.229147988357856,FALSE +"H1703","Pearson.est","ATPase inhibitor",-0.59625,-1.47,0.0734,965,0.458,"blebbistatin...., evodiamine, omeprazole, ouabain, k.strophanthidin, thonzonium, digitoxin, digitoxigenin, oligomycin.a, digoxin",1.13430394008393,0.339134521996131,FALSE +"H1703","Pearson.est","Aurora kinase inhibitor",-0.58796,-1.41,0.105,1022,0.554,"alisertib, hesperadin, KW.2449, CCT137690, tozasertib, MK.5108, MK.8745, barasertib.HQPA, aurora.a.inhibitor.i, danusertib, ZM.447439, AT.9283, SNS.314, AMG900, barasertib, PF.03814735",0.978810700930062,0.25649023527157,FALSE +"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34253,-0.843,0.652,914,0.941,"radezolid, dirithromycin, valnemulin, josamycin",0.18575240426808,0.0264103765727431,FALSE +"H1703","Pearson.est","bacterial DNA gyrase inhibitor",-0.26605,-0.647,0.888,1092,1,"sparfloxacin, lomefloxacin, norfloxacin",0.051587034221399,0,FALSE +"H1703","Pearson.est","BCL inhibitor",-0.31789,-0.765,0.732,630,1,"gossypol, ABT.737, venetoclax, navitoclax, HA14.1, oridonin, TW.37",0.135488918941608,0,FALSE +"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.24403,0.63,0.873,157,0.958,"dasatinib, bosutinib",0.0589857562944303,0.0186344909214556,FALSE +"H1703","Pearson.est","benzodiazepine receptor agonist",0.25366,0.667,0.862,1084,1,"piperazine, CL.218872, zaleplon, gamma.aminobutyric.acid, lorazepam, ivermectin, eprinomectin, ZK.93423, bentazepam, temazepam, nefiracetam, CGS.20625, indiplon",0.0644927341752872,0,FALSE +"H1703","Pearson.est","bromodomain inhibitor",0.31137,0.804,0.641,999,0.929,"JQ1...., OTX015, I.BET.762, I.BET151, PFI.1, bromosporine",0.193141970481183,0.0319842860063582,FALSE +"H1703","Pearson.est","calcium channel blocker",-0.48858,-1.2,0.231,1073,0.581,"penfluridol, pranidipine, SR.33805, carboxyamidotriazole",0.636388020107856,0.235823867609669,FALSE +"H1703","Pearson.est","CC chemokine receptor antagonist",-0.43989,-1.08,0.369,986,0.706,"SB.225002, PF.04136309, MK.0812, UNBS.5162",0.43297363384094,0.151195298948196,FALSE +"H1703","Pearson.est","CDK inhibitor",-0.20165,-0.491,0.987,1180,1,"BMS.265246, R547, abemaciclib, PHA.793887",0.00568284733036327,0,FALSE +"H1703","Pearson.est","CHK inhibitor",-0.27209,-0.667,0.866,1030,1,"SB.218078, PF.477736",0.0624821079826534,0,FALSE +"H1703","Pearson.est","cyclooxygenase inhibitor",-0.37698,-0.911,0.578,1367,0.892,"suxibuzone, naproxen, tepoxalin, AM.404",0.238072161579471,0.0496351456238769,FALSE +"H1703","Pearson.est","cytochrome P450 inhibitor",-0.48054,-1.16,0.284,1150,0.612,"metyrapone, clotrimazole, cobicistat",0.546681659952962,0.213248577854439,FALSE +"H1703","Pearson.est","DNA alkylating agent",-0.57471,-1.39,0.126,1110,0.555,"mitomycin.c, TH.302, carboplatin, dianhydrogalactitol, satraplatin, cisplatin, melphalan",0.899629454882437,0.255707016877324,FALSE +"H1703","Pearson.est","DNA inhibitor",-0.52905,-1.32,0.152,1050,0.555,"pibenzimol, teroxirone, tirapazamine, carboplatin, valrubicin, melphalan, chlorambucil",0.818156412055227,0.255707016877324,FALSE +"H1703","Pearson.est","DNA methyltransferase inhibitor",0.44829,1.19,0.239,196,0.754,"azacitidine, fdcyd, decitabine",0.621602099051862,0.122628654130226,FALSE +"H1703","Pearson.est","DNA polymerase inhibitor",-0.25521,-0.619,0.917,889,1,"idoxuridine, foscarnet, menadione, cephalomannine",0.0376306643299789,0,FALSE +"H1703","Pearson.est","DNA synthesis inhibitor",-0.54212,-1.32,0.17,1015,0.555,"anisomycin, nelarabine, estramustine.phosphate, mitomycin.c, CB.10.277, enocitabine, cisplatin, azodicarbonamide, artemisinin",0.769551078621726,0.255707016877324,FALSE +"H1703","Pearson.est","dopamine receptor antagonist",0.28806,0.749,0.787,86,0.944,"domperidone, clebopride, lurasidone",0.104025267640935,0.025028005701931,FALSE +"H1703","Pearson.est","estrogen receptor agonist",0.35275,0.937,0.502,154,0.843,"erteberel, levonorgestrel, ethinyl.estradiol",0.299296282854981,0.0741724253752577,FALSE +"H1703","Pearson.est","estrogen receptor antagonist",0.38931,1.03,0.401,103,0.799,"clomifene, raloxifene",0.396855627379818,0.0974532206860086,FALSE +"H1703","Pearson.est","FGFR inhibitor",-0.63655,-1.53,0.0448,1168,0.579,"lenvatinib, MK.2461, regorafenib, dovitinib, nintedanib, erdafitinib",1.34872198600186,0.237321436272564,FALSE +"H1703","Pearson.est","FLT3 inhibitor",-0.41195,-0.998,0.473,1057,0.769,"KW.2449, tozasertib, dovitinib, sorafenib, TG.101348, quizartinib, midostaurin",0.325138859262188,0.114073660198569,FALSE +"H1703","Pearson.est","glucocorticoid receptor agonist",0.46794,1.19,0.268,334,0.754,"hydrocortisone, triamcinolone.acetonide, ciclesonide, fluocinolone.acetonide, flumethasone.pivalate, desonide, fludroxycortide, methylprednisolone, difluprednate, dexamethasone.acetate, betamethasone, prednisolone",0.571865205971211,0.122628654130226,FALSE +"H1703","Pearson.est","glutamate receptor antagonist",0.40901,1.07,0.336,213,0.768,"diazooxonorleucine, SIB.1757, CGP.37849, kynurenic.acid, IEM1754, latrepirdine",0.473660722610156,0.114638779968488,FALSE +"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.30028,0.793,0.699,123,0.908,"indirubin, LY2090314",0.155522824254319,0.0419141514789149,FALSE +"H1703","Pearson.est","growth factor receptor inhibitor",0.24111,0.646,0.882,90,0.977,"GSK1904529A",0.0545314148681803,0.0101054362812269,FALSE +"H1703","Pearson.est","HCV inhibitor",-0.5096,-1.24,0.214,1041,0.609,"Ro.9187, mericitabine, narlaprevir",0.669586226650809,0.215382707367125,FALSE +"H1703","Pearson.est","HDAC inhibitor",0.19747,0.519,0.963,1167,1,"JNJ.26481585, panobinostat, romidepsin, PCI.24781, tacedinaline, vorinostat, M.344, givinostat, R306465, mocetinostat, trichostatin.a, ACY.1215, nexturastat.a, AR.42, RGFP966, dacinostat, NSC.3852, pyroxamide, SB.939, belinostat, resminostat, RG2833, entinostat, scriptaid, chidamide",0.0163737128754655,0,FALSE +"H1703","Pearson.est","histamine receptor antagonist",-0.2244,-0.546,0.97,1231,1,"tiotidine, cimetidine, ICI.162846, nizatidine",0.0132282657337552,0,FALSE +"H1703","Pearson.est","HMGCR inhibitor",-0.95639,-2.34,0,1419,0,"mevastatin, fluvastatin, atorvastatin, pitavastatin",Inf,Inf,TRUE +"H1703","Pearson.est","HSP inhibitor",-0.55061,-1.34,0.141,1172,0.589,"PU.H71, SNX.2112, NVP.AUY922, ganetespib, NMS.E973",0.85078088734462,0.229884705212898,FALSE +"H1703","Pearson.est","JAK inhibitor",-0.22983,-0.554,0.95,1284,1,"PRT062070, TG.101348, AT.9283",0.0222763947111523,0,FALSE +"H1703","Pearson.est","KIT inhibitor",-0.49022,-1.21,0.251,1168,0.586,"lenvatinib, telatinib, regorafenib, motesanib, cediranib, sorafenib, midostaurin, pazopanib",0.600326278518962,0.232102383981909,FALSE +"H1703","Pearson.est","MDM inhibitor",-0.46747,-1.13,0.322,873,0.649,"CGM097, AMG.232, serdemetan",0.492144128304169,0.187755303199631,FALSE +"H1703","Pearson.est","MEK inhibitor",0.82206,2.15,0,106,0.0292,"trametinib, AS.703026, cobimetinib, AZD8330, selumetinib, PD.0325901, TAK.733, Ro.4987655, MEK162, PD.318088, refametinib, PD.198306, PD.184352",Inf,1.53461714855158,TRUE +"H1703","Pearson.est","MET inhibitor",-0.33129,-0.803,0.702,776,0.986,"PF.04217903, PHA.665752, AMG458, LY2801653",0.153662887870195,0.0061230850587888,FALSE +"H1703","Pearson.est","microtubule inhibitor",-0.62854,-1.53,0.0586,936,0.579,"triclabendazole, cytochalasin.b, D.64131, estramustine.phosphate, podophyllotoxin, cabazitaxel, secnidazole, vinflunine, vinblastine",1.23210238398191,0.237321436272564,FALSE +"H1703","Pearson.est","mTOR inhibitor",0.18141,0.487,0.984,293,0.984,"GSK2126458, LY303511, PP242, GDC.0980, WAY.600, PF.04691502, OSI.027, XL388",0.00700490156865849,0.00700490156865849,FALSE +"H1703","Pearson.est","NFkB pathway inhibitor",-0.16966,-0.404,0.994,1304,1,"BAY.11.7082",0.00261361560268669,0,FALSE +"H1703","Pearson.est","opioid receptor agonist",-0.35173,-0.861,0.639,745,0.934,"BW.180C, cebranopadol, salvinorin.a, spiradoline",0.1944991418416,0.0296531237699066,FALSE +"H1703","Pearson.est","p38 MAPK inhibitor",0.4594,1.23,0.222,786,0.838,"SB.239063, SB.242235, talmapimod, skepinone.l, TAK.715, CMPD.1, VX.702",0.653647025549361,0.0767559813697235,FALSE +"H1703","Pearson.est","PARP inhibitor",-0.55247,-1.34,0.143,1273,0.589,"olaparib, AZD2461, talazoparib",0.844663962534938,0.229884705212898,FALSE +"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49928,-1.21,0.239,1168,0.586,"lenvatinib, telatinib, crenolanib, regorafenib, motesanib, dovitinib, trapidil, sorafenib, axitinib, CP.673451, nintedanib, pazopanib",0.621602099051862,0.232102383981909,FALSE +"H1703","Pearson.est","phosphatase inhibitor",-0.41229,-1.01,0.461,1019,0.77,"menadione, AS.1949490, BVT.948, bis.maltolato.oxovanadium.IV., GSK2830371",0.336299074610352,0.113509274827518,FALSE +"H1703","Pearson.est","phosphodiesterase inhibitor",-0.38346,-0.952,0.514,1217,0.835,"YM.976, zardaverine, GSK256066",0.289036881004724,0.0783135245163979,FALSE +"H1703","Pearson.est","PI3K inhibitor",0.41176,1.12,0.316,288,0.777,"alpelisib, taselisib, GSK2126458, CH5132799, TG.100713, LY303511, PI.828, GDC.0980, TG100.115, GDC.0941, PF.04691502, PIK.75",0.500312917381596,0.109578981199086,FALSE +"H1703","Pearson.est","PLK inhibitor",-0.66503,-1.65,0.0201,1195,0.445,"GSK461364, HMN.214, BI.2536, rigosertib, volasertib",1.69680394257951,0.351639989019068,FALSE +"H1703","Pearson.est","potassium channel blocker",-0.52198,-1.25,0.221,1424,0.618,"dofetilide",0.655607726314889,0.209011524911184,FALSE +"H1703","Pearson.est","PPAR receptor agonist",-0.42413,-1.03,0.409,935,0.783,"pterostilbene, clofibrate, GW.501516",0.388276691992658,0.106238237942057,FALSE +"H1703","Pearson.est","progesterone receptor agonist",-0.35313,-0.864,0.644,953,0.955,"danazol, norgestrel, norethindrone, dienogest, tanaproget",0.191114132640188,0.0199966284162537,FALSE +"H1703","Pearson.est","proteasome inhibitor",-0.40969,-1.01,0.451,837,0.77,"oprozomib, ixazomib, ONX.0914, delanzomib, MG.132",0.345823458122039,0.113509274827518,FALSE +"H1703","Pearson.est","protein synthesis inhibitor",-0.49598,-1.19,0.259,1124,0.577,"clofoctol, thiostrepton, bruceantin, puromycin, homoharringtonine, mercaptopurine, harringtonine, anguidine",0.586700235918748,0.238824186844269,FALSE +"H1703","Pearson.est","protein tyrosine kinase inhibitor",0.56713,1.53,0.074,153,0.393,"BMS.599626, AV.412, NVP.TAE226, CP.724714",1.13076828026902,0.405607449624573,FALSE +"H1703","Pearson.est","RAF inhibitor",-0.29377,-0.696,0.839,1200,1,"regorafenib, PLX.4720, RAF265, sorafenib",0.0762380391712997,0,FALSE +"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.36254,0.932,0.522,32,0.808,"vandetanib",0.282329496997738,0.0925886392254138,FALSE +"H1703","Pearson.est","retinoid receptor agonist",0.42019,1.11,0.329,43,0.739,"CD.437, tamibarotene",0.482804102050026,0.131355561605174,FALSE +"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.61434,-1.48,0.058,1278,0.65,"gemcitabine, fludarabine, cladribine, pentostatin, clofarabine",1.23657200643706,0.187086643357144,FALSE +"H1703","Pearson.est","serotonin receptor agonist",-0.61085,-1.47,0.0695,1100,0.458,"SR.57227A, pardoprunox, aripiprazole",1.15801519540989,0.339134521996131,FALSE +"H1703","Pearson.est","serotonin receptor antagonist",-0.53052,-1.28,0.173,1259,0.58,"paliperidone, lerisetron, aripiprazole",0.761953896871205,0.236572006437063,FALSE +"H1703","Pearson.est","sodium channel blocker",-0.2486,-0.608,0.914,1294,1,"butamben, cibenzoline",0.0390538042661686,0,FALSE +"H1703","Pearson.est","src inhibitor",0.61949,1.65,0.0552,157,0.356,"saracatinib, dasatinib, ZM.306416, bosutinib",1.2580609222708,0.448550002027125,FALSE +"H1703","Pearson.est","sterol demethylase inhibitor",-0.28998,-0.698,0.829,1133,1,"posaconazole, chlormidazole",0.0814454694497265,0,FALSE +"H1703","Pearson.est","TGF beta receptor inhibitor",0.41788,1.12,0.321,346,0.777,"repsox, LY2109761, D.4476, SB.431542",0.493494967595128,0.109578981199086,FALSE +"H1703","Pearson.est","thymidylate synthase inhibitor",0.30513,0.804,0.703,1008,0.929,"carmofur, capecitabine, raltitrexed, ftorafur, trifluridine, doxifluridine",0.153044674980176,0.0319842860063582,FALSE +"H1703","Pearson.est","topoisomerase inhibitor",-0.75302,-1.82,0.00611,1232,0.167,"dexrazoxane, amsacrine, idarubicin, rubitecan, doxorubicin, voreloxin, valrubicin, nemorubicin, mitoxantrone, amonafide, TAS.103, daunorubicin, topotecan, etoposide, etoposide.phosphate, teniposide, epirubicin",2.21395878975745,0.777283528852417,TRUE +"H1703","Pearson.est","tubulin polymerization inhibitor",-0.60635,-1.47,0.0696,1090,0.458,"plinabulin, epothilone.b, vinorelbine, podophyllotoxin, ABT.751, docetaxel, epothilone.d, dolastatin.10, paclitaxel, CYT.997, vindesine, vincristine, KX2.391, combretastatin.A.4, vinblastine, taltobulin, verubulin, BNC105",1.15739076038944,0.339134521996131,FALSE +"H1703","Pearson.est","tyrosine kinase inhibitor",0.37091,0.969,0.453,153,0.825,"vandetanib, BMS.599626, dasatinib, AV.412, NVP.TAE226, hypericin, CP.724714",0.343901797987168,0.0835460514500749,FALSE +"H1703","Pearson.est","VEGFR inhibitor",-0.29519,-0.718,0.799,1168,1,"lenvatinib, telatinib, MK.2461, regorafenib, motesanib, dovitinib, cediranib, SAR131675, RAF265, sorafenib, axitinib, tivozanib, nintedanib, pazopanib",0.0974532206860086,0,FALSE +"H1703","Pearson.est","vitamin D receptor agonist",0.64785,1.69,0.0452,362,0.394,"tacalcitol, maxacalcitol, calcitriol, paricalcitol, ercalcitriol, alfacalcidol",1.34486156518862,0.404503778174426,FALSE +"HCC15","Pearson.est","EGFR inhibitor",0.70426,1.79,0.0128,140,0.252,"gefitinib, CUDC.101, poziotinib, XL.647, AZD8931, afatinib, pelitinib, erlotinib, lapatinib, dacomitinib, osimertinib, neratinib, BIBU.1361, canertinib, icotinib, tucatinib, vandetanib, PD.153035, AST.1306, WZ.4002, WZ.3146",1.89279003035213,0.598599459218456,FALSE +"HCC15","Pearson.est","Abl kinase inhibitor",0.54588,1.36,0.145,355,0.449,"tozasertib, ZM.306416, dasatinib, GZD824, bafetinib, ponatinib, nilotinib",0.838631997765025,0.347753658996677,FALSE +"HCC15","Pearson.est","acetylcholine receptor agonist",-0.36518,-0.945,0.496,1362,0.771,"nefiracetam",0.304518323509803,0.112945621949043,FALSE +"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.28903,-0.761,0.745,1098,0.942,"darifenacin, dicycloverine, methscopolamine",0.127843727251707,0.0259490972071227,FALSE +"HCC15","Pearson.est","adenosine receptor antagonist",0.42122,1.07,0.365,518,0.677,"sulmazole, istradefylline, CGS.15943, PSB.1115, MRS.1220, SCH.58261",0.437707135543525,0.169411331314856,FALSE +"HCC15","Pearson.est","adrenergic receptor agonist",-0.28056,-0.735,0.762,1129,0.952,"norepinephrine, lidamidine, isoetharine, midodrine, xylazine, clenbuterol",0.1180450286604,0.0213630516155257,FALSE +"HCC15","Pearson.est","adrenergic receptor antagonist",-0.41922,-1.07,0.349,1180,0.703,"prazosin, atenolol...., vincamine, levobunolol, metoprolol, propranolol, pindolol",0.45717457304082,0.153044674980176,FALSE +"HCC15","Pearson.est","AKT inhibitor",0.45043,1.13,0.312,116,0.621,"uprosertib, MK.2206, GSK2110183",0.505845405981557,0.20690839982342,FALSE +"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.42216,1.06,0.391,457,0.67,"CEP.37440, lorlatinib, SB.505124, alectinib, crizotinib, GW.788388",0.407823242604133,0.173925197299174,FALSE +"HCC15","Pearson.est","androgen receptor antagonist",-0.79972,-2.09,0.0023,1386,0.0654,"enzalutamide, RU.58841, cyproterone.acetate",2.63827216398241,1.18442225167573,TRUE +"HCC15","Pearson.est","antioxidant",-0.61264,-1.57,0.0685,1436,0.403,"taurine, rutin",1.16430942850757,0.39469495385889,FALSE +"HCC15","Pearson.est","AP inhibitor",-0.47323,-1.21,0.227,1286,0.747,"birinapant, LCL.161, GDC.0152",0.643974142806877,0.126679398184601,FALSE +"HCC15","Pearson.est","ATPase inhibitor",-0.37987,-1.01,0.438,1225,0.715,"digitoxin, rabeprazole, oligomycin.a, digitoxigenin",0.3585258894959,0.145693958198919,FALSE +"HCC15","Pearson.est","Aurora kinase inhibitor",-0.23658,-0.612,0.913,980,0.909,"hesperadin, AT.9283, aurora.a.inhibitor.i, KW.2449, MK.5108, MLN.8054, CYC116, MK.8745, ZM.447439, PF.03814735",0.039529222465701,0.0414361167780325,FALSE +"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.46994,-1.2,0.249,857,0.66,"tilmicosin, azalomycin.b, tedizolid, dirithromycin, josamycin, radezolid",0.603800652904264,0.180456064458131,FALSE +"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",-0.36423,-0.942,0.491,1245,0.745,"trovafloxacin, nadifloxacin",0.308918507877032,0.127843727251707,FALSE +"HCC15","Pearson.est","BCL inhibitor",0.42031,1.05,0.415,410,0.64,"obatoclax, ABT.737, venetoclax, gossypol",0.381951903287907,0.193820026016113,FALSE +"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",0.55859,1.41,0.126,355,0.428,"tozasertib, dasatinib, GZD824, bafetinib, ponatinib, nilotinib",0.899629454882437,0.368556230986828,FALSE +"HCC15","Pearson.est","benzodiazepine receptor agonist",0.33971,0.874,0.603,207,0.787,"bentazepam, ZK.93423, piperazine, CL.218872",0.219682687859849,0.104025267640935,FALSE +"HCC15","Pearson.est","bromodomain inhibitor",0.5447,1.36,0.147,389,0.449,"I.BET.762, JQ1...., I.BET151, OTX015",0.832682665251824,0.347753658996677,FALSE +"HCC15","Pearson.est","calcium channel blocker",0.30435,0.768,0.747,357,0.845,"penfluridol, SKF.96365, efonidipine.monoethanolate",0.126679398184601,0.0731432910503077,FALSE +"HCC15","Pearson.est","CC chemokine receptor antagonist",0.57888,1.46,0.106,177,0.412,"ZK811752, PF.04136309",0.97469413473523,0.385102783966865,FALSE +"HCC15","Pearson.est","CDK inhibitor",0.36157,0.908,0.564,198,0.775,"indisulam, P276.00, alvocidib, dinaciclib, AT.7519, TG.02",0.248720896016658,0.11069829749369,FALSE +"HCC15","Pearson.est","CHK inhibitor",0.62723,1.57,0.0645,411,0.537,"PF.477736, LY2606368, LY2603618, AZD7762",1.19044028536473,0.270025714300444,FALSE +"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.38956,-1.02,0.425,1019,0.729,"amfenac, acetylsalicylsalicylic.acid, pterostilbene, tryptanthrin, indoprofen, AM.404, sulfasalazine, metoxibutropate, suxibuzone, naproxen",0.371611069949688,0.137272471682025,FALSE +"HCC15","Pearson.est","cytochrome P450 inhibitor",0.38543,0.971,0.477,215,0.688,"metyrapone, morin",0.321481620959886,0.162411561764489,FALSE +"HCC15","Pearson.est","DNA alkylating agent",-0.45028,-1.15,0.278,1218,0.627,"satraplatin, melphalan, cisplatin, streptozotocin, dianhydrogalactitol, mitomycin.c",0.555955204081924,0.202732459169284,FALSE +"HCC15","Pearson.est","DNA inhibitor",-0.26157,-0.69,0.809,1223,0.876,"melphalan, nimorazole, primaquine, tirapazamine",0.0920514783877277,0.0574958938319193,FALSE +"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.33138,0.844,0.631,372,0.791,"azacitidine, decitabine, disulfiram",0.199970640755866,0.101823516502323,FALSE +"HCC15","Pearson.est","DNA polymerase inhibitor",0.3126,0.79,0.704,57,0.834,"cidofovir",0.152427340857888,0.0788339493622613,FALSE +"HCC15","Pearson.est","DNA synthesis inhibitor",-0.62832,-1.62,0.0364,1322,0.634,"cisplatin, artemisinin, floxuridine, estramustine.phosphate, mitomycin.c",1.43889861635094,0.197910742118267,FALSE +"HCC15","Pearson.est","dopamine receptor antagonist",0.29617,0.746,0.761,268,0.835,"clebopride, lurasidone, thioproperazine, domperidone, sertindole",0.118615343229427,0.0783135245163979,FALSE +"HCC15","Pearson.est","estrogen receptor agonist",-0.27324,-0.715,0.789,1425,0.924,"estradiol.cypionate",0.10292299679058,0.0343280287798933,FALSE +"HCC15","Pearson.est","estrogen receptor antagonist",0.53082,1.35,0.163,361,0.438,"raloxifene, clomifene, toremifene, tamoxifen",0.787812395596042,0.3585258894959,FALSE +"HCC15","Pearson.est","FGFR inhibitor",0.5292,1.34,0.187,214,0.428,"regorafenib, PD.173074, MK.2461, lucitanib",0.728158393463501,0.368556230986828,FALSE +"HCC15","Pearson.est","FLT3 inhibitor",0.4777,1.23,0.215,319,0.504,"tozasertib, gilteritinib, pacritinib, tyrphostin.AG.1296, sorafenib, TG.02, sunitinib, ponatinib, lestaurtinib, ENMD.2076",0.667561540084395,0.297569463554475,FALSE +"HCC15","Pearson.est","glucocorticoid receptor agonist",0.39731,1.01,0.449,71,0.686,"hydrocortisone, ciclesonide, triamcinolone.acetonide, difluprednate",0.347753658996677,0.163675884293248,FALSE +"HCC15","Pearson.est","glutamate receptor antagonist",-0.25626,-0.666,0.837,1319,0.88,"latrepirdine, ACDPP",0.07727454200674,0.0555173278498314,FALSE +"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.2738,-0.714,0.793,1169,0.897,"CHIR.98014, kenpaullone, indirubin",0.100726812682396,0.0472075569559079,FALSE +"HCC15","Pearson.est","growth factor receptor inhibitor",0.26463,0.672,0.849,541,0.909,"lestaurtinib, GSK1838705A, PHA.848125, GSK1904529A, danusertib",0.0710923097560473,0.0414361167780325,FALSE +"HCC15","Pearson.est","HCV inhibitor",0.30263,0.759,0.74,72,0.837,"embelin",0.130768280269024,0.07727454200674,FALSE +"HCC15","Pearson.est","HDAC inhibitor",0.61057,1.52,0.0518,178,0.429,"M.344, PCI.24781, R306465, vorinostat, romidepsin, dacinostat, NSC.3852, givinostat, trichostatin.a, tacedinaline, belinostat, panobinostat, JNJ.26481585, nexturastat.a",1.28567024025477,0.367542707815276,FALSE +"HCC15","Pearson.est","histamine receptor antagonist",0.22815,0.585,0.911,397,0.951,"ranitidine, chloropyramine, pheniramine, ebastine, astemizole, tecastemizole, lafutidine",0.0404816230270017,0.0218194830625861,FALSE +"HCC15","Pearson.est","HMGCR inhibitor",0.60472,1.55,0.0599,576,0.424,"pitavastatin, lovastatin, mevastatin, simvastatin, fluvastatin, atorvastatin",1.22257317761069,0.372634143407267,FALSE +"HCC15","Pearson.est","HSP inhibitor",-0.53441,-1.39,0.134,1202,0.503,"KW.2478, XL888, alvespimycin, PU.H71, VER.49009, tanespimycin",0.872895201635192,0.298432014944073,FALSE +"HCC15","Pearson.est","JAK inhibitor",0.33521,0.862,0.614,198,0.785,"atiprimod, tozasertib, pacritinib, TG.02",0.211831628858832,0.105130343254747,FALSE +"HCC15","Pearson.est","KIT inhibitor",0.35174,0.875,0.606,273,0.809,"regorafenib, dasatinib, sorafenib, sunitinib, pazopanib",0.217527375833714,0.0920514783877277,FALSE +"HCC15","Pearson.est","MDM inhibitor",0.38981,1,0.43,159,0.681,"idasanutlin, nutlin.3",0.366531544420413,0.166852888087215,FALSE +"HCC15","Pearson.est","MEK inhibitor",0.59336,1.49,0.0823,239,0.396,"MEK162, cobimetinib, AZD8330, TAK.733, AS.703026, MEK1.2.inhibitor, trametinib, PD.0325901, Ro.4987655, BIX.02188",1.08460016478773,0.402304814074488,FALSE +"HCC15","Pearson.est","MET inhibitor",-0.58926,-1.52,0.0831,1261,0.375,"PF.04217903, NVP.BVU972",1.08039897621589,0.425968732272281,FALSE +"HCC15","Pearson.est","microtubule inhibitor",-0.44819,-1.16,0.29,1253,0.691,"D.64131, cytochalasin.b, estramustine.phosphate",0.537602002101044,0.160521952625802,FALSE +"HCC15","Pearson.est","mTOR inhibitor",-0.27999,-0.716,0.762,1184,0.952,"voxtalisib, deforolimus, sirolimus, everolimus, palomid.529, temsirolimus, GDC.0980, SB.2343",0.1180450286604,0.0213630516155257,FALSE +"HCC15","Pearson.est","NFkB pathway inhibitor",0.71644,1.82,0.0124,190,0.3,"curcumin, parthenolide...., Ro.106.9920, bortezomib, parthenolide",1.90657831483776,0.522878745280338,FALSE +"HCC15","Pearson.est","opioid receptor agonist",-0.6001,-1.56,0.0615,976,0.361,"salvinorin.a, trimebutine, cebranopadol, BW.180C, spiradoline",1.21112488422458,0.442492798094342,FALSE +"HCC15","Pearson.est","p38 MAPK inhibitor",0.50735,1.28,0.193,602,0.474,"SB.242235, talmapimod, SB.239063, CMPD.1, TAK.715",0.714442690992226,0.324221658325915,FALSE +"HCC15","Pearson.est","PARP inhibitor",-0.38577,-1.02,0.405,1074,0.729,"olaparib, AZD2461, E7449",0.392544976785331,0.137272471682025,FALSE +"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.22807,0.569,0.933,404,0.942,"regorafenib, dasatinib, sorafenib, sunitinib, pazopanib, ponatinib, axitinib, dovitinib, SU014813",0.0301183562535,0.0259490972071227,FALSE +"HCC15","Pearson.est","phosphatase inhibitor",0.59487,1.5,0.0802,322,0.418,"GSK2830371, CID.5458317, bis.maltolato.oxovanadium.IV., alexidine, sodium.stibogluconate",1.09582563171584,0.378823718224965,FALSE +"HCC15","Pearson.est","phosphodiesterase inhibitor",-0.41628,-1.08,0.34,1096,0.72,"cilostamide, enoximone, zardaverine, papaverine, GSK256066, YM.976",0.468521082957745,0.142667503568732,FALSE +"HCC15","Pearson.est","PI3K inhibitor",0.25768,0.659,0.843,445,0.902,"buparlisib, YM.201636, LY303511, GSK2126458, CUDC.907, taselisib, TG.100713, pilaralisib, TG100.115, PF.05212384, GDC.0941, AZD6482",0.0741724253752577,0.0447934624580583,FALSE +"HCC15","Pearson.est","PLK inhibitor",-0.60323,-1.59,0.0584,1148,0.549,"volasertib, GSK461364, HMN.214, BI.2536, GW.843682X",1.2335871528876,0.260427655549908,FALSE +"HCC15","Pearson.est","potassium channel blocker",-0.60538,-1.58,0.0605,919,0.461,"oleoylethanolamide, ibutilide, meglitinide, dofetilide, ML133",1.21824462534753,0.336299074610352,FALSE +"HCC15","Pearson.est","PPAR receptor agonist",-0.50694,-1.32,0.166,919,0.58,"oleoylethanolamide, S26948, clofibrate, pterostilbene, ciprofibrate, GW.501516",0.779891911959945,0.236572006437063,FALSE +"HCC15","Pearson.est","progesterone receptor agonist",-0.43211,-1.15,0.271,1380,0.627,"norgestrel, dienogest",0.567030709125594,0.202732459169284,FALSE +"HCC15","Pearson.est","proteasome inhibitor",0.48506,1.22,0.238,115,0.496,"carfilzomib, bortezomib",0.623423042943488,0.304518323509803,FALSE +"HCC15","Pearson.est","protein synthesis inhibitor",0.43125,1.09,0.325,331,0.667,"clindamycin.phosphate, brefeldin.a, tedizolid.phosphate, azomycin..2.nitroimidazole., homoharringtonine, chloramphenicol.palmitate, bruceantin",0.488116639021126,0.175874166083451,FALSE +"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.40273,0.998,0.445,398,0.662,"AV.412, PP.121, NVP.TAE226",0.351639989019068,0.1791420105603,FALSE +"HCC15","Pearson.est","RAF inhibitor",0.76297,1.93,0.00559,275,0.228,"AZ.628, dabrafenib, vemurafenib, regorafenib, CEP.32496, sorafenib, LGX818, SB.590885, TAK.632",2.25258819211358,0.642065152999546,TRUE +"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.57292,1.42,0.111,265,0.442,"vandetanib, regorafenib, sorafenib, sunitinib",0.954677021213343,0.354577730650908,FALSE +"HCC15","Pearson.est","retinoid receptor agonist",0.70912,1.78,0.0156,248,0.202,"tamibarotene, CD.437, adarotene, AM.580, fenretinide",1.80687540164554,0.694648630553376,TRUE +"HCC15","Pearson.est","ribonucleotide reductase inhibitor",-0.37586,-0.962,0.476,1172,0.772,"hydroxyurea, clofarabine, gemcitabine",0.322393047279507,0.112382699664264,FALSE +"HCC15","Pearson.est","serotonin receptor agonist",-0.68449,-1.75,0.0262,1447,0.46,"aripiprazole",1.58169870868025,0.337242168318426,FALSE +"HCC15","Pearson.est","serotonin receptor antagonist",-0.36261,-0.923,0.547,1447,0.749,"aripiprazole",0.262012673666569,0.125518182300534,FALSE +"HCC15","Pearson.est","sodium channel blocker",-0.33154,-0.882,0.563,1301,0.794,"butamben, lappaconite, oxcarbazepine",0.249491605148654,0.100179497572904,FALSE +"HCC15","Pearson.est","src inhibitor",0.49409,1.24,0.216,240,0.512,"saracatinib, ZM.306416, dasatinib, PP.2",0.665546248849069,0.290730039024169,FALSE +"HCC15","Pearson.est","sterol demethylase inhibitor",0.32958,0.829,0.674,646,0.792,"terconazole, sulconazole, lanoconazole, posaconazole, ketoconazole",0.17134010346468,0.101274818410506,FALSE +"HCC15","Pearson.est","TGF beta receptor inhibitor",0.61759,1.55,0.0537,420,0.424,"repsox, D.4476, LY2109761, SB.525334, SB.431542",1.27002571430044,0.372634143407267,FALSE +"HCC15","Pearson.est","thymidylate synthase inhibitor",-0.27094,-0.703,0.806,1161,0.885,"doxifluridine, raltitrexed",0.0936649581949093,0.0530567293021746,FALSE +"HCC15","Pearson.est","topoisomerase inhibitor",-0.5804,-1.5,0.0709,1133,0.361,"valrubicin, rubitecan, etoposide, teniposide, camptothecin, genz.644282, amsacrine, exatecan.mesylate, amonafide, voreloxin, mitoxantrone, TAS.103, idarubicin",1.14935376481693,0.442492798094342,FALSE +"HCC15","Pearson.est","tubulin polymerization inhibitor",-0.31622,-0.81,0.701,1265,0.891,"fenbendazole, CYT.997, ABT.751, epothilone.b, epothilone.d, KX2.391",0.154281982033341,0.0501222959631252,FALSE 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+
+
+ + + + diff --git a/Examples/cell_corr/Fig4 - Coldren/GSEA/GSEA_mean_results.csv b/Examples/cell_corr/Fig4 - Coldren/GSEA/GSEA_mean_results.csv new file mode 100644 index 0000000..ba0e91f --- /dev/null +++ b/Examples/cell_corr/Fig4 - Coldren/GSEA/GSEA_mean_results.csv @@ -0,0 +1,187 @@ +"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"KEGG_HOMOLOGOUS_RECOMBINATION",1.18275,1.01842115997799,1.62474463133865e-07,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1299, HCC44, H1703",7.55506253572471e-06 +"KEGG_DNA_REPLICATION",1.04791666666667,1.53399872338061,5.18696097500436e-08,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,6,"H2126, H460, H1299, HCC44, H1703, HCC15",3.21591580450271e-06 +"KEGG_MISMATCH_REPAIR",1.03566666666667,1.44466663869894,4.40852347906153e-08,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H460, HCC44, A549, H1703",3.21591580450271e-06 +"KEGG_PHENYLALANINE_METABOLISM",1.03283333333333,1.09196876689711,4.39011978278975e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.000680468566332411 +"KEGG_BASE_EXCISION_REPAIR",0.984083333333333,0.910691890650713,0.00385519218170664,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.02353817641561 +"KEGG_PYRIMIDINE_METABOLISM",0.960333333333333,0.735403455542767,0.0575556683431852,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.175497611669384 +"KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.95575,0.241440798314844,0.705125447449297,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.922999363061497 +"KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.951166666666667,0.651452340171675,0.159811080572889,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.377825235366307 +"KEGG_PROTEASOME",0.9135,1.10131850731088,0.00137332360738408,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, A549",0.0106981626914189 +"KEGG_O_GLYCAN_BIOSYNTHESIS",0.860833333333333,1.09987154897398,0.000441836979103135,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.00391341324348491 +"KEGG_SELENOAMINO_ACID_METABOLISM",0.822416666666667,0.961451219235639,0.0275998402701993,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0950661164862421 +"KEGG_RNA_POLYMERASE",0.7885,1.13492582857367,0.00512348170900914,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0277285086897416 +"KEGG_ONE_CARBON_POOL_BY_FOLATE",0.771416666666667,1.26351792147115,6.28560007409116e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.000835086866986397 +"KEGG_PURINE_METABOLISM",0.7655,0.773114304144431,0.417144666625491,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.686627504357003 +"KEGG_ETHER_LIPID_METABOLISM",0.747333333333333,0.853898688192557,0.17373314610447,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC15",0.394077624090627 +"KEGG_HISTIDINE_METABOLISM",0.741833333333333,1.13190256835225,0.00206560546850457,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.014777023736225 +"KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.7295,0.918118382147076,0.148050939649012,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.362335194404161 +"KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.724666666666667,0.86145493559478,0.193542911654831,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.413781397331018 +"KEGG_OOCYTE_MEIOSIS",0.712,1.00645263628792,0.0197732493725514,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.072114203594011 +"KEGG_CALCIUM_SIGNALING_PATHWAY",0.706666666666667,0.425593346951873,0.998346846426198,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_ASTHMA",0.704916666666667,1.10983868265399,0.0118763758905152,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.0471613911971242 +"KEGG_TYPE_I_DIABETES_MELLITUS",0.6985,0.843247887634472,0.593095271824138,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.875521591740394 +"KEGG_TASTE_TRANSDUCTION",0.69725,0.882656128347326,0.198553570390263,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.414954652725718 +"KEGG_VIRAL_MYOCARDITIS",0.680833333333333,0.506877577712685,0.982410393274909,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_TYROSINE_METABOLISM",0.6645,0.93556531281651,0.162505477576906,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.377825235366307 +"KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.658333333333333,1.31386199173784,0.000148532918380909,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, A549",0.00153484015660272 +"KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.658166666666667,1.05997271262762,0.0323073288579678,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.107306485135393 +"KEGG_ALLOGRAFT_REJECTION",0.6395,1.11048437425051,0.206200320144664,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, A549",0.424597927062589 +"KEGG_SPLICEOSOME",0.626333333333333,1.18741180214734,0.00366824597966207,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, H1703",0.0235273707661084 +"KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.623,1.42288254162904,0.000129204824688151,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1648, H460",0.00145713690081867 +"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.62125,0.920005447118262,0.181702152579352,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.394335477996203 +"KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.6165,1.23118040181696,0.000744626347212879,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.00629547729916344 +"KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.603583333333333,1.14805736777261,0.176127393056238,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.394335477996203 +"KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.597583333333333,1.14971359740616,0.00555856187450555,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0277285086897416 +"KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.596916666666667,1.17332917634422,0.00548852272377495,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.0277285086897416 +"KEGG_RNA_DEGRADATION",0.592,1.17083839425198,0.00542506995369291,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0277285086897416 +"KEGG_BETA_ALANINE_METABOLISM",0.58475,1.14564417171381,0.0113183135866127,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0467823628246658 +"KEGG_LINOLEIC_ACID_METABOLISM",0.584083333333333,1.1729841863875,0.0055194143572287,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC15",0.0277285086897416 +"KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.583916666666667,0.870315873517753,0.584069890300629,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.869095996767337 +"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.583666666666667,1.66131204081885,1.32004223058374e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1648, H460, H1299, HCC44",0.000313770381199524 +"KEGG_AUTOIMMUNE_THYROID_DISEASE",0.581,1.09163130639008,0.0384793998439777,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.123399454672066 +"KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.577166666666667,1.0303212944014,0.0842770264726543,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.244930108186151 +"KEGG_GLUTATHIONE_METABOLISM",0.56975,1.25965212549844,0.00392302940260166,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.02353817641561 +"KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.566666666666667,0.611396662395109,0.992143276843358,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_CELL_CYCLE",0.560416666666667,1.19718939477833,0.00617626737248941,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0292555330442391 +"KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.5525,1.38885908048821,2.69543597839784e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.000455773719983634 +"KEGG_MAPK_SIGNALING_PATHWAY",0.5465,0.69266737393145,0.990857642751396,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_GLYCEROLIPID_METABOLISM",0.545583333333333,0.901938463768035,0.506832248307051,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.785589984875929 +"KEGG_ABC_TRANSPORTERS",0.535083333333333,0.946116412050608,0.373795087889975,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.643758206921623 +"KEGG_APOPTOSIS",0.534583333333333,0.862019875148778,0.744240553789745,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.92905196647579 +"KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.53025,0.988659802229996,0.182327156492868,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.394335477996203 +"KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.529916666666667,0.914248370703133,0.477770720338107,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.753096220193964 +"KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.52925,0.76735426510955,0.846556426123929,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.999213161238356 +"KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.52925,0.832234574121766,0.7940475067109,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.968950478899731 +"KEGG_REGULATION_OF_AUTOPHAGY",0.51675,0.96702732169732,0.318599502765129,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.575335024410815 +"KEGG_PYRUVATE_METABOLISM",0.513166666666667,1.19599390644034,0.026745781359501,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0945785775978492 +"KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.505083333333333,1.22176098379149,0.00629151248263206,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0292555330442391 +"KEGG_SULFUR_METABOLISM",0.4995,1.44666189428064,2.8834712876383e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1650, HCC44",0.000107265131900145 +"KEGG_ARACHIDONIC_ACID_METABOLISM",0.499333333333333,1.26575815105797,0.00417677136115664,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.024277483536723 +"KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.49225,0.724787006330449,0.99135428234984,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_LYSINE_DEGRADATION",0.45975,1.08796667103029,0.100513599347604,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.27146421146697 +"KEGG_ARGININE_AND_PROLINE_METABOLISM",0.45525,1.04721137268983,0.275558524263209,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.524107405623711 +"KEGG_RIBOFLAVIN_METABOLISM",0.437583333333333,1.30028545525647,0.0028348312314032,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.0195288373718887 +"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.429166666666667,1.51441833018089,1.34955002666462e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.000313770381199524 +"KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.426333333333333,1.06286194548093,0.143619606101405,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.356176623131485 +"KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.412,0.959973863280568,0.555912435869098,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.833868653803646 +"KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.39925,1.08205252141054,0.226933557191868,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.458800452583558 +"KEGG_GALACTOSE_METABOLISM",0.382416666666667,1.16035946298263,0.0507775631792728,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.157410445855746 +"KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.381833333333333,1.01490741479509,0.416290478907209,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.686627504357003 +"KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.37,1.26955009926566,0.241552912744442,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.47796640181347 +"KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.365,0.968116634596172,0.600336099664643,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.879232397934045 +"KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.363166666666667,1.00323085654058,0.519301279374631,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.791721622653125 +"KEGG_SMALL_CELL_LUNG_CANCER",0.358916666666667,0.867649118263969,0.943731678224006,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_ALZHEIMERS_DISEASE",0.358166666666667,0.929554324622419,0.669238502119766,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.915282069075563 +"KEGG_FATTY_ACID_METABOLISM",0.354333333333333,1.02587384775866,0.405930836397402,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.680953112192685 +"KEGG_CITRATE_CYCLE_TCA_CYCLE",0.3525,1.31083398158299,0.00946191798560483,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.0409282964028488 +"KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.348416666666667,0.743872479092697,0.999213161238356,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.339166666666667,0.931094159219857,0.723493096669306,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.92463761591251 +"KEGG_NITROGEN_METABOLISM",0.339,1.19549495265274,0.0354634091883509,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.11572270366725 +"KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.3375,0.904073659509103,0.881249808502836,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_CARDIAC_MUSCLE_CONTRACTION",0.322583333333333,0.943056679905906,0.73448508160118,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.92463761591251 +"KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.322583333333333,1.04987033470661,0.379890329637474,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.648253223051102 +"KEGG_LONG_TERM_DEPRESSION",0.320083333333333,0.81127446967812,0.992881235392838,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_OLFACTORY_TRANSDUCTION",0.315,0.874280483389835,0.953690880365227,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.3105,0.786003296315087,0.996198943201011,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.309333333333333,1.79860599219271,8.10053586511452e-10,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1648, H460, HCC44, A549",1.5066996709113e-07 +"KEGG_JAK_STAT_SIGNALING_PATHWAY",0.306916666666667,0.855172864857088,0.966891345898313,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_MTOR_SIGNALING_PATHWAY",0.30525,1.10630540950088,0.197312720155791,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.414954652725718 +"KEGG_INSULIN_SIGNALING_PATHWAY",0.3015,0.965583337583133,0.767469942629711,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.945360326682955 +"KEGG_WNT_SIGNALING_PATHWAY",0.2925,0.943532386108905,0.851937140685304,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.28775,1.09179669477759,0.262957498050279,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.509480152472416 +"KEGG_PARKINSONS_DISEASE",0.287583333333333,1.11482387180734,0.160489998856461,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.377825235366307 +"KEGG_BUTANOATE_METABOLISM",0.287416666666667,1.14377735105565,0.13011616548941,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.327048740284192 +"KEGG_HUNTINGTONS_DISEASE",0.2855,1.04759234784945,0.296822232124013,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.541264070343788 +"KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.281,1.14436755061872,0.113207051516311,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.29245154975047 +"KEGG_PRIMARY_IMMUNODEFICIENCY",0.28025,1.06666584398643,0.281686560678008,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.529229295819287 +"KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.280083333333333,1.07041745962909,0.352450544891725,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.612671040652905 +"KEGG_N_GLYCAN_BIOSYNTHESIS",0.277333333333333,1.06797091663953,0.406375244373054,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.680953112192685 +"KEGG_TIGHT_JUNCTION",0.276416666666667,0.868400667720246,0.972872406410684,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_RETINOL_METABOLISM",0.274666666666667,1.0159725598776,0.506506914224674,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.785589984875929 +"KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.27025,1.2747465434352,0.0175175011643979,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"A549, HCC15",0.0651651043315602 +"KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.250916666666667,1.32457989623697,0.00909902061782124,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0402956627360655 +"KEGG_LEISHMANIA_INFECTION",0.243833333333333,1.07423527415666,0.276142611565181,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.524107405623711 +"KEGG_LONG_TERM_POTENTIATION",0.242333333333333,1.00751235799624,0.646188930598406,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.896948814114205 +"KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.241583333333333,1.00715968385747,0.678583512001726,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.919231361206546 +"KEGG_PRION_DISEASES",0.239916666666667,0.973569482820198,0.812301128237938,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.981090973066601 +"KEGG_OXIDATIVE_PHOSPHORYLATION",0.238083333333333,1.09213522791851,0.247144074456024,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.483882082619162 +"KEGG_PATHWAYS_IN_CANCER",0.231166666666667,0.83136370263598,0.996313232939234,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_CELL_ADHESION_MOLECULES_CAMS",0.223916666666667,0.882907434490608,0.973843970930251,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_PEROXISOME",0.223833333333333,1.03663580291189,0.528050223036226,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.798514971420634 +"KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.21025,0.92877134136743,0.913389731129389,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.209083333333333,1.36246404178294,0.00138040808921534,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0106981626914189 +"KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.204166666666667,0.918985689208323,0.946055925044637,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_SPHINGOLIPID_METABOLISM",0.20275,1.01269425745923,0.687425674117467,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.919231361206546 +"KEGG_TYPE_II_DIABETES_MELLITUS",0.201083333333333,1.10981197902522,0.286138204712022,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.532217060764361 +"KEGG_STARCH_AND_SUCROSE_METABOLISM",0.196416666666667,0.911158848373705,0.946888207906333,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.196166666666667,0.957382495361307,0.797039910062682,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.968950478899731 +"KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.191166666666667,1.30139043357713,0.0144677380404855,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0555303641650227 +"KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.188916666666667,1.43690389748447,0.000431357873981221,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, A549",0.00391341324348491 +"KEGG_TRYPTOPHAN_METABOLISM",0.186,1.13953507265822,0.207733394423095,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.424597927062589 +"KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.1765,0.821239473434681,0.997457802953366,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.17,1.3775385822018,0.00187024998002767,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0139146598514059 +"KEGG_PROPANOATE_METABOLISM",0.166666666666667,1.34942636522024,0.00341820436087332,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0227066432543728 +"KEGG_FOLATE_BIOSYNTHESIS",0.159833333333333,1.39932203281273,0.000412499562031675,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1648",0.00391341324348491 +"KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.15625,0.960023875176597,0.922959320748554,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_VEGF_SIGNALING_PATHWAY",0.152916666666667,1.00859573470276,0.735733156747589,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.92463761591251 +"KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.14975,0.996067917089264,0.691894572951164,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.919231361206546 +"KEGG_NON_HOMOLOGOUS_END_JOINING",0.142833333333333,1.49627475802914,1.22446234115451e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, H1703",0.000313770381199524 +"KEGG_GNRH_SIGNALING_PATHWAY",0.138166666666667,1.00859955413735,0.756241030392057,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.937738877686151 +"KEGG_ENDOCYTOSIS",0.138,1.01969585483302,0.690967933686218,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.919231361206546 +"KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.133916666666667,1.02967801307305,0.709617789880614,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.922999363061497 +"KEGG_TGF_BETA_SIGNALING_PATHWAY",0.120416666666667,0.952269772541883,0.92165679067392,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_P53_SIGNALING_PATHWAY",0.119833333333333,1.0361028233752,0.615275040243121,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.889995455352405 +"KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.11525,1.27101499347426,0.0269498097456237,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.0945785775978492 +"KEGG_GAP_JUNCTION",0.11475,0.92768108989321,0.955761270126232,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_COLORECTAL_CANCER",0.113333333333333,1.04936936328733,0.61725491258312,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.889995455352405 +"KEGG_PPAR_SIGNALING_PATHWAY",0.1045,0.976940260572402,0.87749211149283,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_ACUTE_MYELOID_LEUKEMIA",0.09925,1.17302577860537,0.167986704572275,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.385747247536335 +"KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.0965,1.21318195442623,0.0792350539049792,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.237705161714938 +"KEGG_ERBB_SIGNALING_PATHWAY",0.09275,1.01311527882162,0.73347718963101,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.92463761591251 +"KEGG_PROTEIN_EXPORT",0.0808333333333334,1.3605329726607,0.00566496414091495,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0277285086897416 +"KEGG_GLIOMA",0.0746666666666667,1.01783382581328,0.731796143214532,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.92463761591251 +"KEGG_FOCAL_ADHESION",0.0729166666666667,0.892656959290464,0.984067631681609,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_PROSTATE_CANCER",0.065,0.984801595154162,0.865506518106912,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.0590833333333333,1.24789112712268,0.0317833641287381,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.107306485135393 +"KEGG_NOTCH_SIGNALING_PATHWAY",0.0584166666666667,1.16298178351506,0.156893667486884,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.377825235366307 +"KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.0521666666666666,1.04341770885466,0.642201876905927,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.896948814114205 +"KEGG_MELANOGENESIS",0.04625,0.950312113800705,0.925367574526933,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_BASAL_CELL_CARCINOMA",0.0403333333333334,1.05262367732282,0.630672075296952,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.896948814114205 +"KEGG_RENAL_CELL_CARCINOMA",0.0395833333333333,1.11696394166047,0.339992697115245,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602272777747006 +"KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.0379166666666667,1.01578947875606,0.699579691555084,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.922849805881174 +"KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.037,0.978491510624204,0.865445282094194,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_MELANOMA",0.0361666666666667,1.05180233481161,0.6375351509243,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.896948814114205 +"KEGG_BASAL_TRANSCRIPTION_FACTORS",0.0290833333333333,1.30190332404196,0.0097505292275326,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0412181462800242 +"KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.0199166666666667,0.956031899271276,0.924384489444331,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_CHRONIC_MYELOID_LEUKEMIA",0.0126666666666666,1.09718510357877,0.450379706907766,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.729171722886162 +"KEGG_LYSOSOME",0.00900000000000008,1.19592497484355,0.0877809320301828,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.251188513194062 +"KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.00649999999999999,1.41954445317695,0.0119171257326067,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, HCC15",0.0471613911971242 +"KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.00641666666666663,0.968380415326476,0.872451745403344,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_VIBRIO_CHOLERAE_INFECTION",0.000916666666666695,1.09969321823972,0.338036487531776,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602272777747006 +"KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.031,1.03686529325831,0.632772697738134,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.896948814114205 +"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.04225,1.20752166364907,0.0834943715058576,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.244930108186151 +"KEGG_PANCREATIC_CANCER",-0.0475833333333334,1.08774198631287,0.472813214836201,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.75165177743191 +"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.0519166666666668,1.21322451331028,0.106685898879174,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.279487002697553 +"KEGG_DILATED_CARDIOMYOPATHY",-0.0535,0.909920526000136,0.968805279292055,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356 +"KEGG_ENDOMETRIAL_CANCER",-0.0724166666666667,1.11867937224157,0.295554169652486,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.541264070343788 +"KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.09325,1.02480296332337,0.669234436109921,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.915282069075563 +"KEGG_THYROID_CANCER",-0.0981666666666667,1.20495317399273,0.0941710235271367,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.265391066303749 +"KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.13075,1.19859244153678,0.0971475852293205,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.269693296308263 +"KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.132833333333333,1.05591750997831,0.45083197920381,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.729171722886162 +"KEGG_ECM_RECEPTOR_INTERACTION",-0.136333333333333,1.08363322655637,0.517255367933033,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.791721622653125 +"KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.141666666666667,1.18635640308952,0.100704465544198,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.27146421146697 +"KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.155583333333333,1.376243005652,0.0082984260285914,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1648, HCC44",0.0376465180809268 +"KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.165416666666667,1.08005003742111,0.45715206423882,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.733019689210521 +"KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.184333333333333,1.46042835144247,0.0146289669036888,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0555303641650227 +"KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.192916666666667,1.26959631797121,0.0397732491078706,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.125386853119727 +"KEGG_ADHERENS_JUNCTION",-0.220333333333333,1.12136080750402,0.238264989921619,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.476529979843237 +"KEGG_OTHER_GLYCAN_DEGRADATION",-0.2505,1.52869483844583,2.54193253950788e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.000455773719983634 +"KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.292666666666667,1.09985266230886,0.180217714576813,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.394335477996203 +"KEGG_AXON_GUIDANCE",-0.316166666666667,1.05479027069438,0.346730221455237,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.608413407459189 +"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.316416666666667,1.4338357620119,0.000133179179107083,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1703",0.00145713690081867 +"KEGG_STEROID_BIOSYNTHESIS",-0.34275,1.45436328617778,1.86239428967547e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.000384894819866263 +"KEGG_RIBOSOME",-0.448833333333333,1.42171694109835,0.104518943866503,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1650, H1648, H460",0.277721765130995 +"KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.561166666666667,1.48246335740908,7.97270759520263e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.000988615741805126 +"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.569666666666667,1.51132737163145,5.06720602382141e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC95, H1703",0.000725000246485218 +"KEGG_BLADDER_CANCER",-0.59425,1.02532293139106,0.121035286332093,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.308391277503689 diff --git a/Examples/cell_corr/Fig4 - Coldren/GSEA/GSEA_results.csv b/Examples/cell_corr/Fig4 - Coldren/GSEA/GSEA_results.csv new file mode 100644 index 0000000..75301dd --- /dev/null +++ b/Examples/cell_corr/Fig4 - Coldren/GSEA/GSEA_results.csv @@ -0,0 +1,2233 @@ +"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"H1650","Input","KEGG_ABC_TRANSPORTERS",0.21787,0.626,0.962,3673,1,"ABCG2, ABCA5, ABCB8, ABCC1, TAP2, ABCA12, ABCB9, ABCB11, ABCC6",0.0168249279621871,0,FALSE +"H1650","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.25175,0.732,0.865,4849,0.984,"TCF7L1, MAP2K1, AKT2, STAT3, JUP, MTOR, TCF7L2, MAPK3, PIK3R3, RUNX1, AKT3, BAD, RAF1, SOS1, CCNA1, GRB2",0.0629838925351858,0.00700490156865849,FALSE +"H1650","Input","KEGG_ADHERENS_JUNCTION",0.41444,1.19,0.209,5643,1,"TCF7L1, CDH1, SNAI1, CTNND1, ACTB, CSNK2A2, TJP1, ACTN4, RAC1, BAIAP2, SMAD2, NECTIN4, TGFBR2, PARD3, ERBB2, PTPN1, TCF7L2, AFDN, CTNNA1, NECTIN1, EGFR, PTPRJ, MAPK3, PTPRM, ACP1, EP300, SSX2IP, PTPRF, PTPN6, RHOA, NECTIN2, MET, CDC42, IQGAP1, ACTN1",0.679853713888946,0,FALSE +"H1650","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.2253,-0.843,0.645,17522,0.891,"IRS2, PCK2, PRKCQ, PRKAG1, PRKAA2, PPARGC1A, RXRB, LEPR, IRS1, NFKBIE, CAMKK1, IKBKB",0.190440285364732,0.0501222959631252,FALSE +"H1650","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.31265,0.906,0.608,2867,0.963,"GLS, ABAT, GOT2, GAD1, GPT2, GFPT1",0.216096420727265,0.0163737128754655,FALSE +"H1650","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.25839,-0.993,0.413,14636,0.872,"FXYD4, KCNJ1, KRAS, PIK3CG, ATP1B2, PIK3R1, IGF1, FXYD2, PIK3CD, PRKCG, HSD11B1, IRS2, SGK1, NR3C2, IRS1, SLC9A3R2, INSR",0.384049948343599,0.0594835150674328,FALSE +"H1650","Input","KEGG_ALLOGRAFT_REJECTION",0.40437,1.17,0.23,2640,1,"CD40, IL12A, IL12B",0.638272163982407,0,FALSE +"H1650","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.34113,0.989,0.486,1909,0.963,"PLA2G12A, ACOX1, PLA2G4B",0.313363730737707,0.0163737128754655,FALSE +"H1650","Input","KEGG_ALZHEIMERS_DISEASE",0.29454,0.867,0.689,4938,0.969,"CHP1, NDUFAB1, UQCRC2, CALM3, PPP3R1, PSENEN, CACNA1D, CYCS, PPP3CA, CYC1, CAPN1, UQCRFS1, NAE1, BID, GAPDH, MME, GNAQ, CASP7, NDUFS6, APP, NDUFB8, COX6B1, ADAM10, EIF2AK3, MAPK3, UQCR10, CASP8, NDUFA8, GRIN2A, SDHA, ITPR2, NDUFB1, BAD, NDUFV2, CALML6, COX6C, SDHB, NDUFB3, NDUFB9, CALM1, COX8A, NDUFB6, NDUFB7",0.161780778092374,0.0136762229492347,FALSE +"H1650","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.29986,-1.11,0.261,16497,0.782,"AARS2, MARS2, TARS2, CARS2, PARS2, FARS2, WARS2",0.583359492661719,0.106793246940152,FALSE +"H1650","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.34794,1,0.445,6162,1,"NAGK, UGP2, PGM1, GPI, GFPT1, GNE, NANP, GALT, GMPPB, GMPPA, HK2, HK1, PMM2, FPGT, HEXA, NPL, UAP1, UXS1, CYB5R3, GFPT2, PGM2",0.351639989019068,0,FALSE +"H1650","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.3911,1.14,0.264,5709,1,"CHP1, MAP3K5, PPP3R1, MAPK11, TOMM40, CYCS, PPP3CA, BID, RAC1, MAPK13, DERL1, GRIN2A, BCL2L1, BAD, CASP1, MAP2K3, SOD1, GPX1, RAB5A, NEFH, CCS",0.578396073130169,0,FALSE +"H1650","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.25511,0.735,0.848,3229,1,"IFNA5, HSPA2, NFYC, IFI30, HSPA4, TAP2, HSPA1A, TAPBP, HSPA1B, NFYB",0.0716041477432862,0,FALSE +"H1650","Input","KEGG_APOPTOSIS",0.34533,1,0.448,4883,1,"CHP1, PPP3R1, TRADD, ENDOD1, CYCS, PPP3CA, NGF, CAPN1, MAP3K14, BID, ENDOG, AKT2, CASP7, MYD88, IL1R1, PRKACG, IL1RAP, PRKAR1B, CASP8, PIK3R3, PRKACA, AKT3, BCL2L1, BAD, CFLAR, DFFA, PRKAR2A, EXOG",0.348721986001856,0,FALSE +"H1650","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.20615,0.597,0.965,2208,0.995,"PTGES, CYP2E1, CYP4F3, PLA2G12A, PLA2G4B, GPX7",0.0154726866562074,0.00217691925427455,FALSE +"H1650","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.23496,-0.791,0.712,17420,0.929,"ARG2, ALDH1B1, NAGS, GLUD2, ALDH2, PRODH, CPS1, ODC1, GLS2, ACY1, MAOA, AMD1",0.147520006363144,0.0319842860063582,FALSE +"H1650","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.39501,1.17,0.221,2136,1,"TCF7L1, ITGA4, DAG1, CACNA1D, CACNG4, ITGA1, DSC2, SLC8A1, ITGA6, ACTB, ITGB8, DSG2, JUP, PKP2, DSP, ACTN4",0.655607726314889,0,FALSE +"H1650","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.27217,-1,0.38,16230,0.909,"MIOX, UGT2B7, ALDH1B1, ALDH2, UGDH",0.42021640338319,0.0414361167780325,FALSE +"H1650","Input","KEGG_ASTHMA",-0.29495,-1.08,0.342,13707,0.74,"IL4, IL13, PRG2, IL10, FCER1G, EPX, RNASE3, IL5, TNF",0.465973893943865,0.130768280269024,FALSE +"H1650","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.31921,0.922,0.604,1349,0.977,"IFNA5, CD40",0.218963061378868,0.0101054362812269,FALSE +"H1650","Input","KEGG_AXON_GUIDANCE",0.37843,1.12,0.29,5824,1,"CHP1, NTN1, SEMA3E, SEMA3D, PAK4, PPP3R1, RHOD, PPP3CA, NTN4, PTK2, SEMA5A, NFAT5, SRGAP2, EFNA5, LIMK2, RAC1, SRGAP1, NFATC1, PLXNA2, ROBO3, PLXNB1, SEMA3F, SEMA4F, EFNA1, RASA1, PAK6, NFATC3, MAPK3, SEMA7A, SLIT3, EPHB3, PLXNB2, ROBO1, EPHA1, GNAI1, SEMA6B, ITGB1, EPHB4, RHOA, EPHA2, ABLIM1, MET, UNC5C, CFL2, PAK2, EFNA2, ROCK1, UNC5B, UNC5A, CDC42, SEMA3C, SEMA4B, CFL1, LIMK1, CDK5, NCK2",0.537602002101044,0,FALSE +"H1650","Input","KEGG_BASAL_CELL_CARCINOMA",0.25186,0.732,0.877,3854,0.984,"TCF7L1, WNT9A, GLI3, WNT7B, WNT7A, WNT6, FZD6, TCF7L2, FZD9, FZD2",0.0570004066339595,0.00700490156865849,FALSE +"H1650","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.33366,-1.24,0.154,18005,0.774,"GTF2F2, STON1, GTF2F1, GTF2H1, TBPL1, GTF2H2",0.812479279163537,0.111259039317107,FALSE +"H1650","Input","KEGG_BASE_EXCISION_REPAIR",0.27924,0.818,0.771,6434,0.972,"XRCC1, POLE4, POLD1, NEIL3, SMUG1, LIG1, POLE, TDG, POLD2, PARP3, APEX2, MBD4, UNG, POLD3, LIG3",0.112945621949043,0.0123337350737254,FALSE +"H1650","Input","KEGG_BETA_ALANINE_METABOLISM",0.38435,1.12,0.262,6187,1,"ABAT, GAD1, SMS, ECHS1, UPB1, SRM, HADHA, DPYD, ALDH3A2, ALDH9A1",0.581698708680255,0,FALSE +"H1650","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.54217,1.55,0.035,5019,0.766,"ACOT4, SCD5, HACD2, ACAA1, TECR, ACOX1, HACD1, ELOVL6, HADHA, ACOT2, YOD1, ACOT1",1.45593195564972,0.115771230367396,FALSE +"H1650","Input","KEGG_BLADDER_CANCER",0.29146,0.847,0.7,4165,0.971,"E2F1, CDH1, MAP2K1, TYMP, DAPK2, ERBB2, EGF, DAPK1, EGFR, MAPK3, RAF1, CDKN1A",0.154901959985743,0.0127807700919951,FALSE +"H1650","Input","KEGG_BUTANOATE_METABOLISM",0.32002,0.936,0.567,7337,0.979,"ABAT, ACSM1, GAD1, ECHS1, HADHA, OXCT1, ACSM4, HMGCS1, ALDH3A2, PDHA1, ACAT2, AACS, ALDH9A1, PDHB, OXCT2, ALDH5A1, HADH",0.246416941107093,0.00921730819686218,FALSE +"H1650","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.35091,1.02,0.406,4157,1,"CHP1, PPP3R1, MAP2K1, PPP3CA, VAV3, PLCG2, NFAT5, DAPP1, LILRB3, AKT2, MALT1, RAC1, VAV1, NFATC1, NFKBIB, NFATC3, VAV2, MAPK3, PIK3R3, AKT3, RAF1, SOS1",0.391473966422806,0,FALSE +"H1650","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.31627,0.917,0.609,4692,0.962,"ADORA2A, TNNC1, CHP1, CAMK2G, PLCD1, PLCE1, CALM3, GNAS, PPP3R1, CACNA1D, PPP3CA, P2RX2, PLCG2, SLC8A1, PHKB, RYR1, ADRA1B, SPHK2, PHKG2, GNAQ, P2RX5, OXTR, CAMK2D, PRKACG, HTR6, ADCY1, MYLK2, ERBB2, P2RX4, ADCY7, GNA15, PTK2B, ADRB1, EGFR, ADORA2B, PRKACA, GRIN2A, ITPR2, CALML6, PHKG1, TBXA2R, TRPC1, PLCD3, PTAFR, CALM1",0.215382707367125,0.0168249279621871,FALSE +"H1650","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.31587,0.916,0.616,5320,0.955,"TNNC1, UQCRC2, CACNA1D, CACNG4, CYC1, SLC8A1, TNNI3, UQCRFS1, SLC9A1, TPM2, TPM1, COX6B1, UQCR10, CACNA2D2, COX6C, CACNB1, MYL3, COX8A, TNNT2, CACNG1, ATP1B1",0.210419287835575,0.0199966284162537,FALSE +"H1650","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.30497,0.886,0.645,2668,0.959,"ITGA4, GLG1, CDH3, ITGB2, CDH1, PVR, SDC4, NFASC, SDC1, CD226, ITGA6, CD40, ITGB8, F11R, OCLN, CLDN7, CLDN23, CLDN4, SDC2",0.190440285364732,0.0181813928293364,FALSE +"H1650","Input","KEGG_CELL_CYCLE",0.28974,0.842,0.725,8040,0.974,"E2F1, YWHAZ, PLK1, RBL2, E2F4, RAD21, ORC6, YWHAB, CHEK2, CCNE1, SFN, PKMYT1, ANAPC2, SMAD2, CCND3, ANAPC10, CDC23, CHEK1, SMC1B, RBL1, SKP2, RBX1, ANAPC7, CDKN1A, CCNB1, MAD1L1, CDC25A, CDC25B, EP300, CDKN2D, CCNE2, CCNA1, CDC20, CCNA2, HDAC1, CDC6, MCM5, YWHAE, BUB1, MAD2L2, ZBTB17, CUL1, CDC14A, PRKDC, YWHAQ, ESPL1, CDC45, CDK7, WEE2, TGFB3, CDK2, CDC7, MCM6, GADD45A, ORC3, E2F2, SMAD4, TGFB2, BUB1B, CCNB2, MAD2L1, MCM4, CREBBP, CDC14B, TGFB1, DBF4, GADD45B, ORC1, PTTG1, YWHAG, CCNH, CDKN1B, ABL1, YWHAH",0.139661993429006,0.0114410431213845,FALSE +"H1650","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.328,0.948,0.543,4238,1,"CCR3, CCR2, CCL5, CCL28, STAT1, BCAR1, GNG13, MAP2K1, VAV3, STAT2, PRKCD, PTK2, RAP1A, GSK3A, PXN, GRK3, AKT2, STAT3, TIAM1, CXCR1, RAC1, VAV1, CCR1, PRKACG, ADCY1, PARD3, NFKBIB, ADCY7, CXCL16, PTK2B, VAV2, MAPK3, PIK3R3, CCR5, PRKACA, CCL17, AKT3, PRKCZ, CCR4, RAF1, GNG10, SOS1, TIAM2",0.265200170411153,0,FALSE +"H1650","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.21409,-0.779,0.769,17589,0.917,"SHC3, STAT5B, MYC, CDK4, SHC2, RB1, TP53, CDKN2A, GAB2, HDAC2, MECOM, IKBKB",0.114073660198569,0.0376306643299789,FALSE +"H1650","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.44307,-1.63,0.0575,15827,0.422,"PER2, BHLHE41, ARNTL, NPAS2",1.24033215531037,0.374687549038326,FALSE +"H1650","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.44968,1.29,0.129,6590,1,"PC, MDH1, OGDH, ACO2, IDH3B, SDHA, SUCLG1, MDH2, SDHB, IDH2, IDH3A, PDHA1, IDH1, PDHB, SDHC",0.889410289700751,0,FALSE +"H1650","Input","KEGG_COLORECTAL_CANCER",0.26134,0.767,0.832,3976,0.997,"TCF7L1, MAP2K1, CYCS, AKT2, RAC1, SMAD2, TGFBR2, TCF7L2, MAPK3, PIK3R3, AKT3, BAD, RAF1",0.0798766737092761,0.00130484168834428,FALSE +"H1650","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.34221,-1.27,0.143,13893,0.807,"FGA, SERPIND1, F7, CPB2, FGB, F2, SERPING1, F13A1, C6, F5, C4BPA, C7, CR2, MASP1, C1S, THBD, SERPINF2, C4B, PLG, F10, VWF, F2R, C4A, A2M, KLKB1, SERPINA5, MASP2, C3AR1, BDKRB1, C1R, PROS1, CFH, BDKRB2, C2, SERPINE1, PLAT",0.844663962534938,0.0931264652779296,FALSE +"H1650","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.27313,0.79,0.786,4360,0.975,"LDHAL6B, GOT2, SMS, ADI1, TAT, AHCYL2, AHCY, CBS, SRM, DNMT1, DNMT3B, ENOPH1",0.104577453960592,0.0109953843014632,FALSE +"H1650","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.27248,0.792,0.789,3741,0.979,"CCR3, IFNL1, CCR2, IFNL3, CCL5, CSF1R, IL20RB, IFNA5, CCL28, PDGFB, IFNL2, IL6, IFNB1, BMP7, CD40, IL12A, PDGFA, PDGFC, CXCR1, IL9R, CTF1, CCR1, IL1R1, TGFBR2, TNFRSF25, IL12B, OSMR, IL18, PRLR, EGF, CXCL16, IL1RAP, EGFR, ACVR2A, TNFRSF12A, CCR5, TNFRSF18, CCL17",0.10292299679058,0.00921730819686218,FALSE +"H1650","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.3743,1.09,0.32,3310,0.988,"CCL5, IFNA5, DDX58, IRF3, POLR3H, IL6, IFNB1, PYCARD, POLR3K, NFKBIB, IL18, ADAR",0.494850021680094,0.00524305541237188,FALSE +"H1650","Input","KEGG_DILATED_CARDIOMYOPATHY",0.38677,1.12,0.286,5099,1,"TNNC1, ITGA4, DAG1, GNAS, CACNA1D, CACNG4, ITGA1, SLC8A1, ITGA6, ACTB, TNNI3, ITGB8, TPM2, TPM1, PRKACG, ADCY1, ADCY7, ADRB1, PRKACA, CACNA2D2, ITGAV, LMNA, CACNB1, ITGA3, ITGB1, ITGB4, MYL3, ADCY6, TNNT2, CACNG1",0.543633966870957,0,FALSE +"H1650","Input","KEGG_DNA_REPLICATION",0.35107,1.02,0.438,6811,1,"POLE4, POLD1, DNA2, LIG1, POLE, POLA2, RNASEH2A, POLD2, RPA3, RNASEH2C, RPA1, MCM5, RNASEH1, POLD3, RFC2, MCM6, RFC5",0.3585258894959,0,FALSE +"H1650","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.43449,1.27,0.144,5338,1,"ETV7, MAP2K1, NOTCH3, SPIRE1, EGFR, MAPK3, SOS1, ETS2, GRB2, SPIRE2",0.84163750790475,0,FALSE +"H1650","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.23165,-0.823,0.663,16157,0.897,"GSTM3, GSTO1, ALDH3A1, CYP3A4, UGT2B7, MAOB, GSTT2, GSTM1, CYP3A5, MAOA, GSTM2, GSTZ1, GSTA4, GSTP1",0.178486471595227,0.0472075569559079,FALSE +"H1650","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.3639,1.05,0.382,3951,1,"UGT2B17, XDH, CDA, TYMP, TK1, UPP1, CES2, UPB1, UCKL1, NAT2, TK2",0.417936637088291,0,FALSE +"H1650","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.31659,0.929,0.566,4794,0.989,"CHAD, ITGA4, DAG1, SDC4, ITGA1, LAMA5, SDC1, ITGA6, ITGB8, COL5A1, LAMA3, SDC2, HSPG2, LAMB2, LAMB1, LAMC2, LAMB3, ITGAV, TNC, ITGA3, ITGB1, COL11A2, ITGB4",0.247183568811729,0.0048037084028206,FALSE +"H1650","Input","KEGG_ENDOCYTOSIS",0.45307,1.31,0.125,5492,1,"CSF1R, HSPA2, STAMBP, SH3GL2, CBLC, RAB22A, VPS28, VPS4A, EHD2, DNM3, EPN3, AGAP1, FGFR2, SH3GLB2, EHD1, EPN1, AP2S1, ITCH, NEDD4L, CHMP4B, CHMP2A, GRK3, AP2A1, CHMP5, DNAJC6, VPS37B, CXCR1, IQSEC2, CHMP3, RAB11FIP4, HSPA1A, ARAP2, PLD2, VPS4B, PARD3, HSPA1B, ASAP3, ACAP1, PARD6B, ASAP2, VTA1, ARFGAP1, PSD4, EGF, WWP1, CLTB, RAB11A, PIP5K1A, ADRB1, EGFR, CHMP6, RUFY1, TFRC, DAB2, EPN2, CCR5, PRKCI, RAB4A, PRKCZ, IQSEC1, SNF8, EPS15, SH3KBP1, NEDD4, CHMP2B, PLD1, PSD, ASAP1, RAB5C, DNM1, USP8, EHD3, LDLRAP1, CHMP4C, EHD4, SH3GLB1, ARFGAP3, GRK5, MET, RAB11FIP5, STAM2, SH3GL1, ARRB1, CDC42, DNM2, RAB5A",0.903089986991944,0,FALSE +"H1650","Input","KEGG_ENDOMETRIAL_CANCER",0.34995,1.02,0.434,4157,1,"TCF7L1, CDH1, MAP2K1, AKT2, ERBB2, TCF7L2, EGF, PTEN, CTNNA1, EGFR, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1",0.362510270487489,0,FALSE +"H1650","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.37836,1.09,0.313,3705,0.988,"CCL5, ATP6V0D1, MAPK11, ATP6V1C1, PLCG2, NOD1, MAP3K14, TJP1, CXCR1, F11R, RAC1, MAPK13, ATP6V0A1, ADAM10, ATP6V0C, EGFR, ATP6AP1",0.504455662453552,0.00524305541237188,FALSE +"H1650","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.33392,0.979,0.485,4165,0.947,"CAMK2G, GAB1, PAK4, CBLC, MAP2K1, PLCG2, PTK2, TGFA, AKT2, MTOR, CAMK2D, ERBB2, EGF, EGFR, PAK6, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1, CDKN1A",0.314258261397736,0.0236500209967266,FALSE +"H1650","Input","KEGG_ETHER_LIPID_METABOLISM",0.38083,1.1,0.316,6715,1,"PLA2G12A, PAFAH1B3, PLA2G4B, LPCAT2, PAFAH1B1, PLD2, LPCAT1, PLA2G7, PLD1, CHPT1, AGPS, PLA2G10, PLA2G4E, LPCAT4, PAFAH1B2, PLPP1",0.500312917381596,0,FALSE +"H1650","Input","KEGG_FATTY_ACID_METABOLISM",0.23978,0.693,0.903,6379,0.989,"ACAA1, ACOX1, ACSL1, ECHS1, HADHA, ACSL3, CPT1A, ECI1, ALDH3A2, ACAT2, ACADVL, HADHB, CPT1B, ALDH9A1, ACAA2, ACOX3",0.0443122496864942,0.0048037084028206,FALSE +"H1650","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.29266,0.85,0.7,4400,0.974,"MAPK11, MAP2K1, VAV3, PRKCD, PLCG2, PLA2G12A, AKT2, PLA2G4B, RAC1, VAV1, MAPK13, VAV2, MAPK3, PIK3R3, AKT3, RAF1, SOS1, PRKCE, MAP2K3",0.154901959985743,0.0114410431213845,FALSE +"H1650","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.34365,0.998,0.445,5642,0.985,"VASP, DNM3, MAP2K1, VAV3, PRKCD, PLCG2, AKT2, PLA2G4B, SPHK2, LIMK2, RAC1, VAV1, PLD2, ASAP3, ASAP2, ARPC3, PIP5K1A, VAV2, MAPK3, PIK3R3, AKT3, ARPC5L, RAF1, PRKCE, PLD1, ASAP1, DNM1, SCIN, CFL2, CDC42, DNM2, PLCG1, CFL1, PLA2G4F, LIMK1",0.351639989019068,0.00656376950238827,FALSE +"H1650","Input","KEGG_FOCAL_ADHESION",0.3476,1.01,0.448,5345,1,"CHAD, ITGA4, PAK4, ARHGAP35, PDGFB, MYL9, VASP, BCAR1, MAP2K1, ITGA1, VAV3, LAMA5, PTK2, RAP1A, ITGA6, ACTB, PXN, AKT2, PDGFA, FLNB, PDGFC, ITGB8, RAPGEF1, PDGFD, COL5A1, ACTN4, RAC1, VAV1, LAMA3, MYLK2, ERBB2, CCND3, PPP1CB, EGF, PTEN, EGFR, LAMB2, PAK6, VAV2, MAPK3, PIK3R3, AKT3, ARHGAP5, LAMB1, CAV2, MYL5, LAMC2, BAD, RAF1, LAMB3, SOS1, ITGAV, MYL7, TNC, ITGA3, ITGB1, MYL12B, COL11A2, ITGB4, GRB2, RHOA, CAV1, LAMC1, MET, PAK2, ROCK1, CDC42",0.348721986001856,0,FALSE +"H1650","Input","KEGG_FOLATE_BIOSYNTHESIS",0.59623,1.72,0.014,771,0.512,"ALPP, SPR",1.85387196432176,0.290730039024169,FALSE +"H1650","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.3083,-1.18,0.247,17725,0.671,"PFKFB1, PFKFB3, GMDS, PFKM, SORD, ALDOC, KHK, MTMR6",0.607303046740334,0.173277479831008,FALSE +"H1650","Input","KEGG_GALACTOSE_METABOLISM",0.34964,1.02,0.424,7455,1,"B4GALT1, UGP2, PGM1, B4GALT2, GALT, HK2, HK1, AKR1B1, GLB1, PGM2, PFKP, PFKL, GALK1, MGAM",0.372634143407267,0,FALSE +"H1650","Input","KEGG_GAP_JUNCTION",0.31075,0.898,0.628,6281,0.965,"PDGFB, GNAS, MAP2K1, TJP1, PDGFA, PDGFC, PDGFD, GNAQ, TUBA4A, PRKACG, ADCY1, ADCY7, TUBB8, EGF, ADRB1, EGFR, MAPK3, PRKACA, ITPR2, RAF1, GUCY1B1, SOS1, GJD2, GNAI1, GUCY1A1, ADCY6, GRB2, TUBB6, GUCY1A2, MAPK7, HRAS, MAP3K2, TUBA8, PRKACB, SRC, TUBB4B",0.202040356262804,0.0154726866562074,FALSE +"H1650","Input","KEGG_GLIOMA",0.37403,1.09,0.33,4849,0.988,"CAMK2G, E2F1, CALM3, PDGFB, MAP2K1, PLCG2, TGFA, AKT2, PDGFA, MTOR, CAMK2D, EGF, PTEN, EGFR, MAPK3, PIK3R3, AKT3, RAF1, SOS1, CDKN1A, CALML6, CALM1, GRB2",0.481486060122112,0.00524305541237188,FALSE +"H1650","Input","KEGG_GLUTATHIONE_METABOLISM",-0.23609,-0.857,0.634,16990,0.899,"PGD, GSTT2, GPX3, GSTM1, GPX2, ODC1, RRM1, GSTM2, GSTZ1, GSTA4, GSTP1",0.197910742118267,0.0462403082667712,FALSE +"H1650","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.22898,-0.88,0.602,16976,0.884,"AGPAT1, DGKI, ALDH1B1, MBOAT1, ALDH2, DGAT2, GPAT4, DGKG, AGPAT3, AKR1A1",0.220403508742175,0.0535477349869269,FALSE +"H1650","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.25138,0.736,0.86,3291,1,"ACHE, CHKA, LCAT, CDS1, PLA2G12A, PLA2G4B, MBOAT7, LPCAT2, PLD2, DGKE, PLA2G15, DGKA, CHKB, ETNK2, LPCAT1",0.0655015487564323,0,FALSE +"H1650","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.25031,-0.901,0.538,17033,0.917,"MAOB, AMT, SARDH, CTH, MAOA, SHMT2",0.269217724333611,0.0376306643299789,FALSE +"H1650","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.2593,0.756,0.846,6578,1,"ALDH3B2, PGAM1, PGM1, GAPDH, FBP2, GALM, PGAM4, LDHAL6B, ACSS2, GPI, ALDOA, ACSS1, HK2, HK1, ALDH1A3, ALDH3B1, ALDH3A2, PDHA1, ENO1, PGM2, ALDH9A1, PKM, PFKP, PDHB",0.0726296369609765,0,FALSE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.46894,1.38,0.0727,4591,1,"CHST14, XYLT1, CHST7, CHST12, B4GALT7, CHPF, DSE, CHST11, CHST15, CSGALNACT1, CHST3",1.13846558914096,0,FALSE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.39462,1.14,0.239,3145,1,"XYLT1, NDST1, EXT2, HS2ST1, B4GALT7, EXT1",0.621602099051862,0,FALSE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.53584,1.56,0.0371,2510,0.864,"CHST6, B4GALT4, B4GALT1, ST3GAL1, B4GALT2, B3GNT2",1.43062609038495,0.0634862575211067,FALSE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.35799,1.05,0.383,764,1,"HPSE, GALNS",0.416801226031377,0,FALSE +"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.34124,0.982,0.467,5398,0.949,"ST6GALNAC5, ST3GAL1, B4GALNT1, B3GALT4, HEXA, GLB1",0.330683119433888,0.0227337875727074,FALSE +"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.46931,1.36,0.0791,1325,1,"FUT9, FUT1, ST3GAL1",1.10182351650232,0,FALSE +"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.62171,1.78,0.00867,2766,0.527,"B3GNT3, B4GALT4, B4GALT1, FUT9, FUT1, FUT3, ST3GAL4, B4GALT2, B3GNT2, ABO",2.06198090252379,0.278189384787453,FALSE +"H1650","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.45711,1.32,0.111,4292,1,"GPAA1, PIGQ, PIGT, PIGO, PIGK, PIGG, PIGX, GPLD1, PIGU, PIGV, PIGN, PIGL",0.954677021213343,0,FALSE +"H1650","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.57196,1.68,0.0122,4273,0.503,"MDH1, MTHFD2, ACO2, PGP, GRHPR, MTHFD1L, MDH2",1.91364016932525,0.298432014944073,FALSE +"H1650","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.33254,0.958,0.529,6405,0.992,"CAMK2G, CALM3, GNAS, CACNA1D, MAPK11, MAP2K1, PRKCD, PLA2G12A, PLA2G4B, GNAQ, PLD2, CAMK2D, PRKACG, ADCY1, MAPK13, ADCY7, PTK2B, EGFR, MAPK3, PRKACA, ITPR2, RAF1, SOS1, CALML6, PLD1, MAP2K3, CALM1, ADCY6, GRB2, CDC42, MMP2, MAPK7, CGA, HRAS, PLA2G10, MAP3K2, PRKACB, SRC, PLA2G4E, HBEGF",0.276544327964814,0.00348832784582135,FALSE +"H1650","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.24724,-0.889,0.608,11132,0.903,"IFNG, FASLG, KIR3DL2, IL2, FAS, CD28, KIR3DL1, KIR2DL3, PRF1, KLRD1, GZMB, CD86, TNF, IL1B, IL1A",0.216096420727265,0.0443122496864942,FALSE +"H1650","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.2994,0.861,0.692,3717,0.966,"BMP5, WNT9A, BMP7, GLI3, WNT7B, WNT7A, WNT6, PRKACG, PRKACA, GAS1",0.159893905543242,0.0150228735845067,FALSE +"H1650","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.27752,0.809,0.767,3762,0.981,"CSF1R, ITGA4, ITGA1, IL6, ANPEP, ITGA6, MME, IL9R, IL1R1, CD14, TFRC, CD59, CD9, CD55",0.115204636051019,0.0083309926200515,FALSE +"H1650","Input","KEGG_HISTIDINE_METABOLISM",-0.35664,-1.35,0.107,15605,0.718,"DDC, HAL, AOC1, AMDHD1, ALDH3A1, MAOB, ACY3, ALDH1B1, ALDH2, HNMT, METTL2B, MAOA",0.97061622231479,0.1438755557577,FALSE +"H1650","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.49845,1.45,0.043,6516,1,"POLD1, RAD51, XRCC3, POLD2, RPA3, NBN, RPA1, RAD52, EME1, XRCC2, RAD51C, RAD54B, POLD3, BLM",1.36653154442041,0,FALSE +"H1650","Input","KEGG_HUNTINGTONS_DISEASE",0.21549,0.624,0.948,5129,1,"DNAI1, NDUFAB1, UQCRC2, POLR2K, CYCS, CYC1, POLR2I, POLR2C, AP2S1, UQCRFS1, DCTN1, DNAL1, AP2A1, DNAL4, GNAQ, NDUFS6, PPARG, NDUFB8, TAF4, TBPL2, TGM2, COX6B1, HAP1, CLTB, UQCR10, CASP8, NDUFA8, HTT, POLR2A, SDHA, NDUFB1, NDUFV2, COX6C, SDHB, EP300, NDUFB3, NDUFB9, SOD1, COX8A, NDUFB6, HDAC1, NDUFB7, TBP, CREB3, VDAC2",0.0231916626619338,0,FALSE +"H1650","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.37839,1.11,0.29,2500,1,"TNNC1, ITGA4, DAG1, CACNA1D, CACNG4, ITGA1, IL6, SLC8A1, PRKAA1, ITGA6, PRKAG2, ACTB, TNNI3, ITGB8, TPM2, TPM1",0.537602002101044,0,FALSE +"H1650","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.34387,0.992,0.478,5527,0.992,"PLCD1, PLCE1, PLCG2, PIK3C2B, INPP4B, IMPA2, INPP5A, MINPP1, INPP1, ITPK1, PIP4K2C, INPP5E, PTEN, PIP5K1A, SYNJ1, INPP4A, INPPL1, PLCD3, IPPK, PIK3C2G, ISYNA1, CDIPT, PLCG1",0.320572103387881,0.00348832784582135,FALSE +"H1650","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.28638,0.834,0.735,4861,0.974,"CBLC, CALM3, GYS1, MAP2K1, PRKAA1, PPP1R3C, PRKAG2, PHKB, PPP1R3D, AKT2, RAPGEF1, FBP2, SOCS1, MTOR, PHKG2, SH2B2, PRKACG, PTPN1, PPP1CB, PRKAR1B, MAPK3, FLOT2, PIK3R3, PRKACA, AKT3, PRKCI, PRKCZ, BAD, RAF1, SOS1, CALML6, PHKG1, TSC1, HK2, HK1, PTPRF, CALM1, RPTOR, GRB2, PRKAR2A",0.133712660915805,0.0114410431213845,FALSE +"H1650","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.39617,1.13,0.262,1524,1,"ITGA4, CCL28, IL6, CD40, MAP3K14",0.581698708680255,0,FALSE +"H1650","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.30651,0.899,0.62,6363,0.972,"IFNL1, IFNL3, IL20RB, IFNA5, CBLC, STAT1, IFNL2, STAT4, STAT2, IL6, IFNB1, IL12A, AKT2, STAT3, IL9R, SOCS1, CTF1, IRF9, IL12B, CCND3, OSMR, SPRED2, PRLR, PIAS1, PIK3R3, AKT3, BCL2L1, TYK2, IFNLR1, SOS1, EP300, IL11RA, PTPN6, GRB2, JAK1, STAM2, SPRY3, IL3RA, JAK2, PIM1, IFNE, CLCF1, IL22, CSF3R, PIK3CB, IL4R, STAM, IL15",0.207608310501746,0.0123337350737254,FALSE +"H1650","Input","KEGG_LEISHMANIA_INFECTION",0.36569,1.05,0.366,2960,1,"ITGA4, ITGB2, STAT1, FCGR3B, MAPK11, IL12A, NCF4, MYD88, TAB2, IL12B, NFKBIB, MAPK13",0.436518914605589,0,FALSE +"H1650","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.4217,1.22,0.181,5643,1,"ITGA4, ARHGAP35, ITGB2, MYL9, CTNND1, VASP, MAPK11, BCAR1, VAV3, RASSF5, PLCG2, PTK2, RAP1A, ACTB, PXN, F11R, OCLN, ACTN4, RAC1, CLDN7, VAV1, NCF4, CLDN23, CLDN4, MAPK13, AFDN, PTK2B, CTNNA1, VAV2, PIK3R3, ARHGAP5, MYL5, MYL7, GNAI1, CLDN9, ITGB1, MYL12B, RHOA, EZR, CLDN8, ESAM, ROCK1, CDC42, MMP2, PLCG1, CLDN1, ACTN1",0.742321425130815,0,FALSE +"H1650","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.27111,0.792,0.797,6187,0.979,"ECHS1, HADHA, YOD1, ALDH3A2, ALDH9A1",0.0985416786038876,0.00921730819686218,FALSE +"H1650","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.2528,0.718,0.879,1909,0.992,"CYP2E1, PLA2G12A, PLA2G4B",0.0560111249262281,0.00348832784582135,FALSE +"H1650","Input","KEGG_LONG_TERM_DEPRESSION",0.23816,0.685,0.902,4678,0.983,"GNAO1, GNAS, PPP2R1A, MAP2K1, PLA2G12A, RYR1, PLA2G4B, GNAQ, MAPK3, ITPR2, RAF1, GUCY1B1, GNAI1, GUCY1A1, GNA12",0.0447934624580583,0.00744648216786438,FALSE +"H1650","Input","KEGG_LONG_TERM_POTENTIATION",0.38026,1.11,0.298,4692,1,"CHP1, CAMK2G, CALM3, PPP3R1, MAP2K1, PPP3CA, RAP1A, RPS6KA1, GNAQ, CAMK2D, PRKACG, ADCY1, PPP1CB, MAPK3, PRKACA, GRIN2A, ITPR2, RAF1, CALML6, EP300, CALM1",0.525783735923745,0,FALSE +"H1650","Input","KEGG_LYSINE_DEGRADATION",0.33936,0.991,0.472,6687,0.982,"BBOX1, OGDH, PLOD2, KMT5A, KMT5C, SETD2, ECHS1, HADHA, PLOD1, AASDHPPT, AADAT, NSD2, KMT5B, ALDH3A2, SETD1A, ACAT2, ALDH9A1, SETD1B, NSD1, PLOD3, TMLHE, EHMT1",0.326058001365912,0.00788851221305034,FALSE +"H1650","Input","KEGG_LYSOSOME",0.32758,0.943,0.552,5502,0.981,"AP1G1, AP3S1, GGA2, CTSV, ATP6V0D1, GALNS, MFSD8, GM2A, AP4E1, MANBA, LAPTM4A, CTSA, ARSA, AP1M2, GNPTAB, DNASE2, ACP2, CTSH, PPT1, ABCB9, PLA2G15, AP1S1, ATP6V0A1, LAMP3, ATP6V0C, CLTB, CTSZ, GALC, ATP6AP1, AP4M1, PPT2, AP1B1, NAGPA, CTSL, CD68, ATP6V0A4, HEXA, GLB1, PSAP, NAGLU, SLC11A1",0.258060922270801,0.0083309926200515,FALSE +"H1650","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.30049,0.879,0.675,4157,0.967,"CHP1, DUSP14, NTF4, HSPA2, STK3, MAP3K5, HSPB1, PDGFB, PPP3R1, CACNA1D, CACNG4, MAPK11, MAP2K1, PPP3CA, FGFR2, TAOK3, RAP1A, PLA2G12A, NGF, MAP3K14, FGF11, FGF2, MAPK8IP2, JUND, AKT2, PDGFA, FLNB, PLA2G4B, MAPKAPK3, RPS6KA1, RAC1, MAP3K6, MAP3K8, ECSIT, HSPA1A, PPP5C, MAP4K2, IL1R1, TGFBR2, TAB2, PRKACG, RPS6KA4, RASGRP4, HSPA1B, RRAS, CD14, MAPK13, NF1, MAP3K20, TAOK2, EGF, NFKB2, MAPK8IP3, EGFR, STK4, RASA1, MAPK3, DUSP9, PRKACA, AKT3, RAF1, CACNA2D2, MAP4K3, RAPGEF2, SOS1",0.170696227168975,0.0145735259169983,FALSE +"H1650","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.50536,-1.87,0.0385,15732,0.276,"HNF4A, BHLHA15, HNF1A, HHEX, ONECUT1, FOXA3, HNF1B, FOXA2, GCK, HNF4G",1.4145392704915,0.559090917934782,FALSE +"H1650","Input","KEGG_MELANOGENESIS",0.35633,1.04,0.385,5327,1,"TCF7L1, CAMK2G, GNAO1, CALM3, GNAS, WNT9A, MAP2K1, WNT7B, GNAQ, WNT7A, MITF, WNT6, CAMK2D, PRKACG, ADCY1, FZD6, TCF7L2, ADCY7, FZD9, MAPK3, PRKACA, FZD2, RAF1, CALML6, EP300, GNAI1, CALM1, FZD1, ADCY6, CREB3, KITLG, WNT9B",0.414539270491499,0,FALSE +"H1650","Input","KEGG_MELANOMA",0.33754,0.983,0.502,4165,0.957,"E2F1, CDH1, PDGFB, MAP2K1, FGF11, FGF2, AKT2, PDGFA, PDGFC, PDGFD, MITF, EGF, PTEN, EGFR, MAPK3, PIK3R3, AKT3, BAD, RAF1, CDKN1A",0.299296282854981,0.0190880622231565,FALSE +"H1650","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.25715,-0.943,0.484,16157,0.9,"GSTM3, GSTO1, ALDH3A1, CYP3A4, UGT2B7, GSTT2, GSTM1, CYP3A5, AKR1C2, AKR1C1, AKR1C3, GSTM2, GSTZ1, GSTA4, GSTP1",0.315154638355588,0.0457574905606751,FALSE +"H1650","Input","KEGG_MISMATCH_REPAIR",0.43736,1.26,0.137,6811,1,"POLD1, EXO1, LIG1, PMS2, POLD2, RPA3, RPA1, POLD3, RFC2, RFC5",0.863279432843593,0,FALSE +"H1650","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.27644,0.801,0.791,7014,0.988,"PRKAA1, AKT2, RPS6KA1, MTOR, ULK2, DDIT4, MAPK3, PIK3R3, RICTOR, AKT3, CAB39, ULK1, TSC1, RPTOR, MLST8, RHEB, TSC2, PIK3CB, EIF4E, VEGFB, BRAF, VEGFC",0.101823516502323,0.00524305541237188,FALSE +"H1650","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.34616,1.02,0.417,3669,1,"CHP1, IFNA5, RAET1E, HCST, ITGB2, RAET1G, RAET1L, FCGR3B, PPP3R1, MAP2K1, PPP3CA, VAV3, PLCG2, IFNB1, NFAT5, BID, RAC1, VAV1, NFATC1, PTK2B, ULBP2, NFATC3, VAV2, MAPK3, PIK3R3",0.379863945026242,0,FALSE +"H1650","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.18027,0.518,0.99,5211,0.998,"GRIN3B, ADORA2A, ADRA2A, OPRK1, MLNR, THRB, CHRM4, P2RY2, P2RX2, S1PR5, TRPV1, LPAR2, ADRA1B, HTR1D, ADRA2B, S1PR1, P2RX5, OXTR, HTR6, PARD3, P2RX4, GABRE, PRLR, S1PR2, ADRB1, P2RY13, F2RL1, ADORA2B, GRIN2A, GALR2, VIPR1, GRM4, S1PR3, GABBR2, TBXA2R, GABRB3, PTAFR, GALR3, CHRNA4, P2RY6, NR3C1, GPR156, GLRB, C5AR1",0.00436480540245009,0.000869458712628891,FALSE +"H1650","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.31006,0.911,0.622,4851,0.959,"NTF4, CAMK2G, GAB1, MAP3K5, CALM3, YWHAZ, MAPK11, MAP2K1, PRKCD, PLCG2, RAP1A, YWHAB, NGF, ZNF274, AKT2, RAPGEF1, RPS6KA1, RAC1, TP73, CAMK2D, SH2B2, RPS6KA4, NFKBIB, ARHGDIB, MAPK13, RIPK2, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1, CALML6, CALM1, SH2B1, GRB2, RHOA",0.206209615309181,0.0181813928293364,FALSE +"H1650","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.31926,-1.18,0.198,18057,0.671,"PNP, NAMPT, NMNAT3, NNT, NADSYN1",0.703334809738469,0.173277479831008,FALSE +"H1650","Input","KEGG_NITROGEN_METABOLISM",-0.42922,-1.55,0.0435,15897,0.426,"CA7, HAL, CA3, CA14, AMT, CA8, GLUD2, CTH, CPS1, CA12, GLS2, CA13",1.36151074304536,0.370590400897281,FALSE +"H1650","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.34318,0.999,0.451,4230,0.995,"CCL5, MAPK11, IL6, NOD1, TAB3, PYCARD, TAB2, NFKBIB, IL18, MAPK13, RIPK2, MAPK3, CASP8, NLRC4, ERBIN, CARD8, CASP1",0.345823458122039,0.00217691925427455,FALSE +"H1650","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.23973,0.694,0.91,5915,0.995,"XRCC4, XRCC6, NHEJ1, PRKDC",0.0409586076789064,0.00217691925427455,FALSE +"H1650","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.33667,0.983,0.492,4157,0.957,"E2F1, MAP2K1, RASSF5, PLCG2, TGFA, AKT2, ERBB2, EGF, RXRA, EGFR, STK4, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1",0.30803489723264,0.0190880622231565,FALSE +"H1650","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.36217,1.06,0.379,5177,1,"DTX4, PSENEN, KAT2B, DTX3L, NOTCH3, JAG2, DTX2, NUMBL, KAT2A, CTBP2, LFNG, EP300, HDAC1, DLL3, MAML2, HES5",0.421360790031928,0,FALSE +"H1650","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.33265,0.968,0.487,4716,0.971,"ERCC4, POLE4, POLD1, RAD23A, GTF2H5, LIG1, POLE, ERCC2, ERCC1, RBX1, POLD2, RPA3, ERCC6, CETN2, RAD23B, RPA1",0.312471038785366,0.0127807700919951,FALSE +"H1650","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.30488,0.893,0.63,5036,0.959,"MGAT5B, MAN1B1, B4GALT1, RPN2, MGAT3, DPM1, STT3A, B4GALT2, STT3B, ALG12, MAN2A1, RFT1, MGAT4A, MOGS, DOLPP1, MGAT1, MGAT2, DDOST",0.200659450546418,0.0181813928293364,FALSE +"H1650","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.17232,-0.651,0.939,10204,1,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR6A2, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, ADCY3, OR5B3, OR10G3, OR10H1, OR1D2, OR52M1, OR2A7, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51E1, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR1N1, OR2C1, OR10G4, PDC, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR5AK2, CLCA1, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR4D5, OR5K2, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, CNGA3, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, CAMK2B, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, OR51E2, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR1B1, OR2L3, OR8D1, OR11H6, OR52N4, OR10V1, CLCA4, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5B21, OR5M11, OR13G1, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR52D1, OR51I1, OR52N2, OR8S1, OR2AT4, OR9A2, OR51Q1, OR13D1, ARRB2, OR8D2, OR2T33, OR1J2, OR2A5, OR52H1, CALM2, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, OR2T8, CALML3, OR4D1, OR8G1, OR4F15, OR52B6, OR2A25, GUCY2D, OR1Q1, OR8A1, CALML5, OR2B2, OR1K1, OR4F3, OR11H4, OR51B4, OR13A1, OR10AD1, OR6B2, OR2K2, OR13H1, OR7D2, OR2A14, OR13J1, OR4F16, OR4F17, OR2W3, PDE1C, OR56B4, OR1L8, OR2AE1, OR2H2, PRKX, OR52W1, GUCA1B, PRKG1, PRKG2",0.0273344077338891,0,FALSE +"H1650","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.29854,0.862,0.706,6661,0.972,"MTHFD2, MTHFS, MTHFR, MTHFD1L, SHMT1, DHFR, ATIC, MTHFD2L",0.151195298948196,0.0123337350737254,FALSE +"H1650","Input","KEGG_OOCYTE_MEIOSIS",0.39828,1.16,0.243,5310,1,"CHP1, CAMK2G, CALM3, YWHAZ, PLK1, PPP2R1A, PPP3R1, MAP2K1, PPP3CA, AURKA, YWHAB, PPP2R5E, CCNE1, PKMYT1, RPS6KA1, ANAPC2, SPDYA, CAMK2D, PRKACG, ADCY1, PPP1CB, ANAPC10, ADCY7, CDC23, SMC1B, SGO1, FBXO5, REC8, MAPK3, PRKACA, ITPR2, RBX1, ANAPC7, CCNB1, CALML6, CCNE2, CALM1, CDC20, ADCY6, YWHAE, BUB1, MAD2L2, PPP2CA",0.614393726401688,0,FALSE +"H1650","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.23116,0.673,0.928,5738,0.987,"MANBA, NEU2, MAN2C1, HEXA, GLB1, FUCA2",0.0324520237811379,0.00568284733036327,FALSE +"H1650","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.25352,0.736,0.879,5038,1,"NDUFAB1, UQCRC2, ATP6V0D1, ATP6V1C1, CYC1, UQCRFS1, LHPP, NDUFS6, NDUFB8, COX17, ATP6V0A1, COX6B1, ATP6V0C, COX15, UQCR10, NDUFA8, ATP6AP1, SDHA, NDUFB1, NDUFV2, ATP5MG, COX6C, SDHB, NDUFB3, NDUFB9, COX8A, NDUFB6, ATP6V1B1, NDUFB7, ATP6V0A4",0.0560111249262281,0,FALSE +"H1650","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.46457,1.34,0.102,5221,1,"C1GALT1, GALNT7, GALNT3, B4GALT5, ST3GAL1, GALNT6, GALNT2, GALNT14, GALNT12, GALNT10, GCNT4, C1GALT1C1, GALNT9, GALNT13, GCNT1",0.991399828238082,0,FALSE +"H1650","Input","KEGG_P53_SIGNALING_PATHWAY",0.36095,1.06,0.366,4216,1,"TP53AIP1, SIAH1, TP53I3, CYCS, EI24, CHEK2, BID, CCNE1, SFN, PERP, IGFBP3, GTSE1, SERPINB5, TP73, CCND3, CHEK1, SHISA5, PTEN, CASP8, RRM2, CDKN1A, CCNB1",0.436518914605589,0,FALSE +"H1650","Input","KEGG_PANCREATIC_CANCER",0.35285,1.01,0.45,4020,1,"E2F1, STAT1, MAP2K1, TGFA, AKT2, STAT3, RAC1, SMAD2, TGFBR2, ERBB2, EGF, RAD51, RALA, EGFR, MAPK3, RALBP1, PIK3R3, AKT3, BCL2L1, BAD, RAF1, RALB",0.346787486224656,0,FALSE +"H1650","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.19433,0.559,0.98,5637,1,"PPCS, UPB1, PANK4, DPYD, PPCDC",0.00877392430750515,0,FALSE +"H1650","Input","KEGG_PARKINSONS_DISEASE",0.20965,0.613,0.97,4938,1,"NDUFAB1, UQCRC2, PINK1, UBE2G1, CYCS, CYC1, UQCRFS1, UBE2L6, TH, UBA7, NDUFS6, NDUFB8, COX6B1, UQCR10, NDUFA8, UBE2G2, SDHA, NDUFB1, NDUFV2, COX6C, SDHB, NDUFB3, NDUFB9, COX8A, NDUFB6, PARK7, NDUFB7",0.0132282657337552,0,FALSE +"H1650","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.32728,0.955,0.523,6605,0.99,"CDH1, YWHAZ, ACTB, OCLN, TUBA4A, KRT18, CD14, ARPC3, TUBB8, ARPC5L, ITGB1, RHOA, TUBB6, EZR, ROCK1, CDC42, CLDN1, NCK2, YWHAQ, TUBA8, TUBB4B, TUBB3, TUBA1B",0.281498311132726,0.00436480540245009,FALSE +"H1650","Input","KEGG_PATHWAYS_IN_CANCER",0.28172,0.821,0.745,5527,0.975,"CSF1R, TCF7L1, E2F1, CBLC, STAT1, CDH1, PDGFB, WNT9A, MAP2K1, CYCS, TFG, IL6, RASSF5, LAMA5, PLCG2, PTK2, FGFR2, EGLN3, ITGA6, EPAS1, GLI3, TGFA, BID, CCNE1, FGF11, FGF2, TRAF4, WNT7B, AKT2, PDGFA, STAT3, JUP, MTOR, RAC1, DAPK2, SMAD2, WNT7A, EGLN2, LAMA3, MITF, PPARG, TGFBR2, WNT6, ERBB2, CUL2, FZD6, TCF7L2, EGF, PTEN, RAD51, NFKB2, DAPK1, FZD9, CTNNA1, RALA, RXRA, EGFR, STK4, CTBP2, LAMB2, PIAS1, MAPK3, RALBP1, CASP8, PIK3R3, RUNX1, AKT3, LAMB1, BCL2L1, FZD2, LAMC2, BAD, RAF1, SKP2, RBX1, RALB, LAMB3, SOS1, CDKN1A, ITGAV, PLD1, EP300, BMP2, CCNE2, CCNA1, ITGA3, ITGB1, FZD1, GRB2, RHOA, HDAC1, LAMC1, MET, FOS, ELOC, PML, JAK1, KITLG, WNT9B, RALGDS, CDC42, FGF1, APPL1, MMP2, PLCG1",0.127843727251707,0.0109953843014632,FALSE +"H1650","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.31844,0.925,0.574,4890,0.99,"UGT2B17, UGP2, RPEL1, RPE, DHDH, AKR1B1",0.241088107602027,0.00436480540245009,FALSE +"H1650","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.36285,1.04,0.374,3657,1,"PGM1, PGLS, RPEL1, FBP2, GPI, RBKS, RPE, ALDOA, DERA",0.42712839779952,0,FALSE +"H1650","Input","KEGG_PEROXISOME",0.31307,0.918,0.612,5734,0.979,"PXMP4, XDH, ACAA1, ECH1, SLC25A17, NUDT19, ACOX1, PEX10, PEX13, PRDX5, ACOT8, ACSL1, MPV17L, PEX3, MVK, DECR2, ACSL3, PEX14, SOD1, PRDX1, GSTK1, IDH2, ABCD1, IDH1, AGPS",0.213248577854439,0.00921730819686218,FALSE +"H1650","Input","KEGG_PHENYLALANINE_METABOLISM",0.32357,0.923,0.591,5986,0.985,"ALDH3B2, GOT2, TAT, PRDX6, ALDH1A3, ALDH3B1, MIF, GOT1",0.228412519118745,0.00656376950238827,FALSE +"H1650","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.34337,1,0.437,4869,1,"PLCD1, PLCE1, CALM3, CDS1, PLCG2, PIK3C2B, INPP4B, IMPA2, INPP5A, INPP1, ITPK1, DGKE, PIP4K2C, DGKA, INPP5E, PTEN, PIP5K1A, PIK3R3, SYNJ1, ITPR2, INPP4A, CALML6, INPPL1, PLCD3, IPPK, CALM1, PIK3C2G",0.359518563029578,0,FALSE +"H1650","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.45732,1.32,0.11,3279,1,"EARS2, UGT2B17, BLVRB, HMOX2, FTH1, ALAS1, UROS, HMOX1, ALAS2, COX15",0.958607314841775,0,FALSE +"H1650","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.2677,0.777,0.813,3351,0.988,"SLC27A6, SCD5, ANGPTL4, SLC27A4, ACAA1, ACOX1, PPARG, ACSL1, FABP5, RXRA",0.0899094544059319,0.00524305541237188,FALSE +"H1650","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.37845,1.09,0.304,245,0.988,"CYP7B1",0.517126416391246,0.00524305541237188,FALSE +"H1650","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.24562,-0.922,0.588,15016,0.909,"ZAP70, LCK, CD3D, IL2RG, CD19, RAG1, BTK, TNFRSF13C, IGLL1, CD4, DCLRE1C, JAK3, RFXAP",0.230622673923862,0.0414361167780325,FALSE +"H1650","Input","KEGG_PRION_DISEASES",0.36312,1.07,0.351,3687,1,"CCL5, MAP2K1, IL6, HSPA1A, PRKACG, STIP1, MAPK3, PRKACA",0.454692883534176,0,FALSE +"H1650","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.32122,0.94,0.571,5242,0.979,"PLK1, MAPK11, MAP2K1, AKT2, PKMYT1, RPS6KA1, ANAPC2, SPDYA, PRKACG, ADCY1, ANAPC10, MAPK13, ADCY7, CDC23, MAPK3, PIK3R3, PRKACA, AKT3, RAF1, ANAPC7, CCNB1, CDC25A, CDC25B, GNAI1, CCNA1, ADCY6, CCNA2, BUB1, MAD2L2",0.243363891754152,0.00921730819686218,FALSE +"H1650","Input","KEGG_PROPANOATE_METABOLISM",-0.26429,-0.96,0.439,16336,0.906,"SUCLA2, LDHC, EHHADH, PCCB, ACADM, ALDH1B1, ALDH2, ACSS3, ALDH6A1, PCCA",0.357535479757879,0.0428718023231869,FALSE +"H1650","Input","KEGG_PROSTATE_CANCER",0.289,0.839,0.717,4535,0.972,"TCF7L1, E2F1, PDGFB, MAP2K1, FGFR2, TGFA, CCNE1, AKT2, PDGFA, PDGFC, PDGFD, MTOR, ERBB2, TCF7L2, EGF, PTEN, EGFR, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1, CDKN1A, EP300, CCNE2",0.1444808443322,0.0123337350737254,FALSE +"H1650","Input","KEGG_PROTEASOME",0.29886,0.876,0.685,6227,0.966,"PSMA2, PSMB10, PSMC4, PSMA7, PSMB6, PSMD11, PSMB3, PSMD8, PSMD12, PSMF1, PSMD7, PSMB1, PSMB11, PSMB2, PSMC3, PSMA6, PSMA4, PSMB9, PSMB7",0.164309428507574,0.0150228735845067,FALSE +"H1650","Input","KEGG_PROTEIN_EXPORT",-0.33128,-1.19,0.188,17269,0.805,"SPCS2, SEC62, IMMP2L, OXA1L, SEC63",0.72584215073632,0.0942041196321315,FALSE +"H1650","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.24015,0.694,0.905,2164,0.995,"GLS, MDH1, SLC25A10",0.0433514207947967,0.00217691925427455,FALSE +"H1650","Input","KEGG_PURINE_METABOLISM",0.20608,0.601,0.965,6278,1,"POLR2K, XDH, GDA, POLR3H, PAPSS2, POLR2I, POLE4, POLR2C, POLD1, DGUOK, ADK, NME4, NUDT9, ENTPD6, POLR3K, ADCY1, PAPSS1, NPR1, NME3, POLE, ADCY7, ADA, AK2, PDE8A, PDE5A, POLA2, RRM2, POLR2A, POLD2, NME6, GUCY1B1, PDE6G, GUCY1A1, ADCY6, ENTPD2, POLR1A, GUCY1A2, AK4, AK1, POLR2F, NT5C3A, PDE9A, DCK, NT5C2, ENTPD5, ATIC, PNPT1, POLD3, PKM, PAICS",0.0154726866562074,0,FALSE +"H1650","Input","KEGG_PYRIMIDINE_METABOLISM",0.35272,1.02,0.429,4082,1,"DHODH, POLR2K, CDA, POLR3H, POLR2I, POLE4, POLR2C, POLD1, DTYMK, CMPK2, TYMP, NME4, TK1, ENTPD6, POLR3K, UPP1, CTPS1, NME3, POLE, UPB1, UCKL1, DUT, POLA2, RRM2, POLR2A, TK2, POLD2, NME6",0.367542707815276,0,FALSE +"H1650","Input","KEGG_PYRUVATE_METABOLISM",0.32653,0.943,0.546,6578,0.981,"PC, MDH1, LDHAL6B, ACSS2, GRHPR, ACSS1, MDH2, AKR1B1, ALDH3A2, PDHA1, ACAT2, ALDH9A1, PKM, ME3, PDHB",0.262807357295263,0.0083309926200515,FALSE +"H1650","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.3528,1.03,0.428,5643,1,"PFN4, SSH2, ITGA4, PAK4, ARHGAP35, ITGB2, PDGFB, MYL9, CHRM4, MYH14, BCAR1, MAP2K1, ITGA1, VAV3, PTK2, FGFR2, ITGA6, ACTB, ARHGEF1, FGD3, PXN, FGF11, FGF2, PDGFA, PDGFC, ITGB8, PDGFD, TIAM1, SLC9A1, LIMK2, ACTN4, RAC1, BAIAP2, VAV1, RDX, PFN1, MYLK2, PIP4K2C, RRAS, PPP1CB, CD14, ARPC3, EGF, PIP5K1A, EGFR, CYFIP1, PAK6, VAV2, MAPK3, SSH3, PIK3R3, MYL5, ARPC5L, RAF1, BRK1, SOS1, TIAM2, ITGAV, MYL7, MRAS, GNA12, ITGA3, ITGB1, MYH9, MYL12B, ITGB4, SCIN, NCKAP1, RHOA, CFL2, EZR, PAK2, ROCK1, CDC42, ITGAE, FGF1, IQGAP1, CFL1, LIMK1, ACTN1",0.368556230986828,0,FALSE +"H1650","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.45218,1.32,0.0937,3126,1,"IFNA5, GABARAPL2, ATG12, PRKAA1, ATG4B, ULK2, ATG7, ATG4D",1.02826040911222,0,FALSE +"H1650","Input","KEGG_RENAL_CELL_CARCINOMA",0.40227,1.16,0.243,7564,1,"GAB1, PAK4, PDGFB, MAP2K1, EGLN3, RAP1A, EPAS1, TGFA, AKT2, RAPGEF1, RAC1, EGLN2, CUL2, PAK6, MAPK3, PIK3R3, AKT3, RAF1, RBX1, SOS1, EP300, GRB2, MET, PAK2, ELOC, CDC42, SLC2A1, HRAS, PIK3CB, TGFB3, VEGFB, BRAF, CRKL, VEGFC, SOS2, CRK, TGFB2, FLCN, CREBBP, ETS1, TGFB1",0.614393726401688,0,FALSE +"H1650","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.4735,1.38,0.0795,1966,1,"ACE2, ANPEP, MME, CTSA",1.09963287134353,0,FALSE +"H1650","Input","KEGG_RETINOL_METABOLISM",0.17876,0.516,0.992,1040,0.992,"DHRS9, UGT2B17, CYP26B1",0.00348832784582135,0.00348832784582135,FALSE +"H1650","Input","KEGG_RIBOFLAVIN_METABOLISM",0.23988,0.689,0.914,4592,0.986,"MTMR2, ACP2, MTMR1, ACP1, PHPT1",0.0390538042661686,0.0061230850587888,FALSE +"H1650","Input","KEGG_RIBOSOME",-0.68738,-2.46,0,16978,0.0188,"RPL34, RPL4, RPL35A, RPL19, RPL26, RPL39, RPS17, RPL17, RPL37A, RPS7, RPL18A, RPS4Y1, RPS3, RPS29, RPL9, RPL38, RPL7, RPL5, RPS3A, RPLP0, RPL22L1, RPL31, RPL23A, RPS27A, RPS23, RPL27, RPS8, RPS25, RPS4X, RPS27, RPL36A, RPS15, RPS18, RPL3, RPS28, RPS10, RPL10A, RPL21, RPL10, RPL36, RPLP2, RPS12, RPL27A, RPS13, RPL30",Inf,1.72584215073632,TRUE +"H1650","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.38733,1.12,0.295,4825,1,"IFNA5, DDX58, IRF3, IFIH1, TRADD, ISG15, MAPK11, ATG12, IFNB1, IL12A, CYLD, TANK, IL12B, NFKBIB, MAPK13, CASP8, AZI2, DHX58, TKFC, TRIM25, TBK1, TBKBP1",0.530177984021837,0,FALSE +"H1650","Input","KEGG_RNA_DEGRADATION",0.37899,1.09,0.332,4271,0.988,"PARN, EXOSC6, LSM4, EDC4, DCPS, TENT4A, CNOT3, PATL1, CNOT1, EXOSC1, C1D, SKIV2L, EXOSC4, CNOT8, CNOT4, LSM5, LSM3, PAPOLB, EXOSC3, EXOSC5, EXOSC10",0.478861916295964,0.00524305541237188,FALSE +"H1650","Input","KEGG_RNA_POLYMERASE",0.30447,0.889,0.643,1179,0.96,"POLR2K, POLR3H, POLR2I, POLR2C",0.191789027075778,0.0177287669604316,FALSE +"H1650","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.32823,0.945,0.538,5641,0.997,"PAPSS2, PAPSS1, AHCYL2, AHCY, CBS, LCMT1, GGT1, GGT7, MAT2B, MAT2A",0.269217724333611,0.00130484168834428,FALSE +"H1650","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.24963,0.732,0.876,4699,0.984,"E2F1, CYCS, LAMA5, PTK2, ITGA6, CCNE1, TRAF4, AKT2, LAMA3, PTEN, RXRA, LAMB2, PIAS1, PIK3R3, AKT3, LAMB1, BCL2L1, LAMC2, SKP2, LAMB3, ITGAV, CCNE2, ITGA3, ITGB1",0.0574958938319193,0.00700490156865849,FALSE +"H1650","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.18256,0.528,0.99,3492,1,"STX11, YKT6, STX16, VAMP8, VTI1A",0.00436480540245009,0,FALSE +"H1650","Input","KEGG_SPHINGOLIPID_METABOLISM",0.28335,0.825,0.742,4756,0.983,"SPTLC1, SMPD4, SPHK2, ARSA, DEGS1, GALC, NEU2, SMPD3, B4GALT6, SGMS2",0.129596094720973,0.00744648216786438,FALSE +"H1650","Input","KEGG_SPLICEOSOME",0.29423,0.86,0.681,6805,0.96,"SF3B3, DHX38, HSPA2, CTNNBL1, PCBP1, LSM4, PRPF31, AQR, SRSF6, PUF60, TRA2A, SNRNP70, USP39, PHF5A, HSPA1A, U2AF2, SRSF9, SNRPA, HSPA1B, SNRPD3, PRPF40B, PRPF38A, SNRNP27, CHERP, U2SURP, LSM5, LSM3, SMNDC1, SNRPD2, TXNL4A, PPIE, BCAS2, SNRPG, PRPF4, ALYREF, SF3B4, BUD31, PRPF6, ZMAT2, DHX15, LSM6, SRSF4, PRPF38B, PLRG1, SNRPA1, RBM22, DDX46, DDX42, RBM25, HSPA6, HNRNPK, CWC15, PRPF8, SRSF8, SF3B5, PQBP1, WBP11",0.166852888087215,0.0177287669604316,FALSE +"H1650","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.27188,0.799,0.788,6169,0.983,"UGT2B17, GYS1, UGP2, PGM1, AMY1A, GPI, HK2, HK1, AMY1B, UXS1, PYGL, PGM2, AGL",0.103473782510445,0.00744648216786438,FALSE +"H1650","Input","KEGG_STEROID_BIOSYNTHESIS",0.24322,0.713,0.88,7038,0.99,"DHCR24, SQLE, MSMO1, SOAT1, SC5D, EBP, LIPA",0.0555173278498314,0.00436480540245009,FALSE +"H1650","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.39955,1.16,0.241,1208,1,"SULT2B1, SULT1E1, CYP7B1, SRD5A1, UGT2B17, CYP1B1",0.617982957425132,0,FALSE +"H1650","Input","KEGG_SULFUR_METABOLISM",0.72982,2.13,0.00107,4125,0.0607,"SULT2B1, SULT1E1, PAPSS2, SULT1A4, CHST12, PAPSS1, SULT1A3, CHST11, SULT1A2, SUOX",2.97061622231479,1.21681130892474,TRUE +"H1650","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.16749,-0.598,0.964,14929,0.975,"FCGR2C, C7, GRIN2B, CD86, CTSG, C1S, C4B, ACTN2, C4A, FCGR2A, TNF, SNRPD1, C1R, C2",0.0159229660971692,0.0109953843014632,FALSE +"H1650","Input","KEGG_TASTE_TRANSDUCTION",0.44181,1.3,0.119,4814,1,"KCNB1, TAS2R1, GNAS, GNG13, TAS2R43, TAS2R20, PRKACG, SCNN1G, TAS2R46, PRKACA, GRM4, TAS2R5, ASIC2, ADCY6",0.924453038607469,0,FALSE +"H1650","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.42673,1.23,0.178,4965,1,"CSAD, GAD1, GGT1, GGT7",0.749579997691106,0,FALSE +"H1650","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.29894,-1.1,0.213,17791,0.745,"IDI1, FDPS, PDSS2",0.671620396561262,0.127843727251707,FALSE +"H1650","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.25714,0.749,0.848,5940,1,"BMP5, PPP2R1A, RBL2, E2F4, BMP7, SMAD2, NOG, ZFYVE16, TGFBR2, SMAD6, GDF6, ACVR2A, MAPK3, RBL1, ID1, RBX1, EP300, BMP2, AMH, SMAD1, RHOA, ID4, BMPR1A, ROCK1, PPP2CA, CUL1, ID3, THBS1, SMURF1",0.0716041477432862,0,FALSE +"H1650","Input","KEGG_THYROID_CANCER",0.38796,1.14,0.253,3590,1,"TCF7L1, CDH1, MAP2K1, TFG, PPARG, TCF7L2, RXRA, MAPK3",0.596879478824182,0,FALSE +"H1650","Input","KEGG_TIGHT_JUNCTION",0.43013,1.27,0.142,6038,1,"MYH15, SPTAN1, EPB41L1, MYL9, MYH14, PPP2R1A, SYMPK, CGN, PRKCD, ACTB, CSNK2A2, MYH3, TJP3, TJP1, AKT2, F11R, OCLN, ACTN4, AMOTL1, CLDN7, CLDN23, LLGL2, CLDN4, EXOC3, PARD3, RRAS, PARD6B, MAP3K20, AFDN, PTEN, CTNNA1, YBX3, TJP2, AKT3, PRKCI, CASK, MYL5, PRKCZ, PRKCE, PPP2R2D, MYL7, GNAI1, MRAS, CLDN9, MYH9, MYL12B, RHOA, VAPA, PATJ, PPP2R2C, MPDZ, CLDN8, PPP2CA, CDC42, CLDN1, ACTN1, PRKCH, MYH7B, MAGI1, HRAS",0.847711655616944,0,FALSE +"H1650","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.40139,1.17,0.219,3889,1,"CCL5, TLR1, IFNA5, TLR6, STAT1, IRF3, MAPK11, MAP2K1, IL6, IFNB1, CD40, IL12A, AKT2, RAC1, MAP3K8, MYD88, TAB2, IL12B, CD14, MAPK13, TLR3, TIRAP, MAPK3, CASP8, PIK3R3, AKT3, TICAM2",0.659555885159882,0,FALSE +"H1650","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.20627,-0.762,0.798,16293,0.916,"IDO1, AOC1, AFMID, EHHADH, MAOB, ALDH1B1, KYNU, ALDH2, TPH1, MAOA, WARS2",0.0979971086492706,0.0381045263321496,FALSE +"H1650","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.19465,-0.699,0.885,15050,0.985,"CACNA1A, SLC2A4, PIK3CG, MAPK8, CACNA1B, PIK3R1, PIK3CD, CACNA1G, TNF, CACNA1C, GCK, IRS2, KCNJ11, IRS1, INSR, IKBKB",0.0530567293021746,0.00656376950238827,FALSE +"H1650","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.21764,0.634,0.955,2786,1,"IL12A, IL12B, GAD1",0.0199966284162537,0,FALSE +"H1650","Input","KEGG_TYROSINE_METABOLISM",-0.16285,-0.608,0.976,18363,1,"FAH, METTL2B, MAOA, GSTZ1",0.0105501823333082,0,FALSE +"H1650","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.31339,0.894,0.652,5345,0.966,"CHP1, PAK4, CBLC, PPP3R1, MAPK11, MAP2K1, PPP3CA, VAV3, NFAT5, MAP3K14, AKT2, MALT1, VAV1, MAP3K8, NFATC1, NFKBIB, MAPK13, PAK6, NFATC3, VAV2, MAPK3, PIK3R3, AKT3, RAF1, SOS1, PTPN6, GRB2, RHOA, FOS, PAK2, CDC42",0.18575240426808,0.0150228735845067,FALSE +"H1650","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.41684,1.23,0.159,5940,1,"FBXO2, UBE2D4, SIAH1, FBXW7, UBR5, CBLC, WWP2, UBE2G1, HUWE1, ITCH, NEDD4L, UBE2E2, UBA2, UBE2L6, HERC3, SOCS1, ANAPC2, UBA7, SAE1, UBE2M, CUL2, UBE2E1, UBE2S, ANAPC10, CDC23, MID1, FANCL, WWP1, UBE4B, NHLRC1, PIAS1, HERC1, UBE2C, UBE2G2, UBE2D3, SKP2, RBX1, UBE3B, ANAPC7, UBE3A, NEDD4, KEAP1, FBXW8, UBE2K, CDC20, UBE2R2, UBE2Z, ELOC, PML, TRIP12, BIRC6, FBXO4, UBE2H, BRCA1, CUL1, BIRC2, UBE2B, SMURF1",0.798602875679548,0,FALSE +"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.43174,1.25,0.145,6890,1,"PDHA1, PDHB, BCAT2, IARS2",0.838631997765025,0,FALSE +"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.28153,0.824,0.743,7002,0.977,"ABAT, ACAA1, BCKDHA, HIBADH, ACAD8, MCEE, AOX1, ECHS1, HADHA, OXCT1, HMGCS1, MCCC2, ALDH3A2, ACAT2, HSD17B10, HADHB, ALDH9A1, ACAA2, BCAT2, MCCC1, OXCT2",0.129011186239425,0.0101054362812269,FALSE +"H1650","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.31606,0.917,0.597,4851,0.962,"ADORA2A, CALM3, MYL9, GNAS, CACNA1D, MAP2K1, PRKCD, PLA2G12A, ARHGEF1, KCNMB4, ADRA1B, PLA2G4B, GNAQ, PRKACG, ADCY1, MYLK2, NPR1, PPP1CB, ADCY7, KCNMA1, MAPK3, ADORA2B, PRKACA, KCNMB3, ITPR2, RAF1, GUCY1B1, PRKCE, CALML6, GUCY1A1, GNA12, CALM1, ADCY6, RHOA",0.224025668870631,0.0168249279621871,FALSE +"H1650","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.33906,0.989,0.47,6295,0.963,"DYNC1LI2, GNAS, DCTN1, DCTN5, DYNLL2, PRKACG, ARHGDIB, RAB11A, PRKACA, DYNC1H1, AQP3, RAB5C, ADCY6, CREB3, RAB5A, DYNLL1, STX4, PRKACB, CREB3L1",0.327902142064283,0.0163737128754655,FALSE +"H1650","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.41642,1.21,0.181,3976,1,"CHP1, HSPB1, PPP3R1, MAPK11, MAP2K1, PPP3CA, PLCG2, PTK2, PLA2G12A, NFAT5, PXN, AKT2, PLA2G4B, SPHK2, MAPKAPK3, RAC1, NFATC1, MAPK13, NFATC3, MAPK3, PIK3R3, AKT3, BAD, RAF1",0.742321425130815,0,FALSE +"H1650","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.42622,1.23,0.178,5632,1,"ATP6V0D1, ERO1A, GNAS, ATP6V1C1, PLCG2, ACTB, TJP1, KDELR1, PRKACG, ATP6V0A1, ATP6V0C, PRKACA, TJP2, ATP6AP1, KDELR2, SEC61G, ARF1, ATP6V1B1, ATP6V0A4, PLCG1, ATP6V1E1, SEC61A2",0.749579997691106,0,FALSE +"H1650","Input","KEGG_VIRAL_MYOCARDITIS",0.50373,1.47,0.0502,2152,1,"MYH15, DAG1, ITGB2, MYH14, CYCS, ACTB, CD40, MYH3, BID, EIF4G1, CXADR, RAC1",1.29929628285498,0,FALSE +"H1650","Input","KEGG_WNT_SIGNALING_PATHWAY",0.2983,0.867,0.687,4006,0.969,"CHP1, TCF7L1, CAMK2G, SIAH1, WNT9A, PPP2R1A, PPP3R1, PPP3CA, NFAT5, CSNK2A2, PPP2R5E, CTNNBIP1, WNT7B, RAC1, SMAD2, WNT7A, NFATC1, WNT6, CAMK2D, VANGL2, PRKACG, CCND3, FZD6, TCF7L2, FZD9, CTBP2, NFATC3, DAAM1, PRKACA, LRP5, FZD2, RBX1",0.16304326294045,0.0136762229492347,FALSE +"HCC95","Input","KEGG_ABC_TRANSPORTERS",0.30702,1.02,0.399,1853,0.813,"ABCG1, ABCC1, ABCA4, ABCB6, ABCA13, TAP2, ABCC5",0.399027104313252,0.0899094544059319,FALSE +"HCC95","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.30346,0.993,0.45,4099,0.819,"EIF4EBP1, IKBKB, GRB2, BAD, PIK3CA, JUP, PIK3R2, CEBPA, MYC, LEF1, BRAF, PIK3CB, CCNA1, KRAS, PML, HRAS, MAPK1, PIM1, RUNX1, AKT2",0.346787486224656,0.0867160982395816,FALSE +"HCC95","Input","KEGG_ADHERENS_JUNCTION",0.27962,0.913,0.556,5098,0.863,"NECTIN1, RAC3, YES1, NLK, PTPN6, EGFR, SNAI2, LEF1, CDH1, CSNK2A2, MET, MAP3K7, IGF1R, WASF3, PTPRB, CSNK2A1, TJP1, MAPK1, SRC, PTPN1, SMAD2, TGFBR1, BAIAP2, RAC1, ERBB2",0.254925208417942,0.0639892042847904,FALSE +"HCC95","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.44892,1.47,0.0673,4121,0.508,"ADIPOR1, ACSL6, ADIPOR2, POMC, IKBKB, CAMKK1, RXRA, IRS1, CPT1A, MAPK9, MAPK10, ACSL3, SLC2A4, NFKBIB, PRKAA1, PRKCQ, SLC2A1, ACACB, PRKAG2, MAPK8, TRADD, AKT2, CAMKK2",1.17198493577602,0.294136287716081,FALSE +"HCC95","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.49111,1.61,0.0408,3522,0.475,"GLS2, GLUL, GOT2, ASNS, ALDH4A1, CAD, ASS1, GOT1, ALDH5A1, GPT2, GAD1",1.38933983691012,0.323306390375133,FALSE +"HCC95","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.29786,0.976,0.455,3156,0.821,"ATP1B3, SFN, SCNN1A, PIK3CA, PIK3R2, IRS1, ATP1A1, PIK3CB, KRAS",0.341988603342888,0.0856568428805592,FALSE +"HCC95","Input","KEGG_ALLOGRAFT_REJECTION",0.21337,0.697,0.882,15037,1,"CD40, CD86, IL12A, FAS, IFNG, CD40LG, IL2, CD28, FASLG, IL12B, GZMB, CD80, IL4, PRF1, IL10, TNF, IL5",0.0545314148681803,0,FALSE +"HCC95","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.33598,1.1,0.314,2278,0.707,"FADS2, PLA2G4B, PLA2G4A, PLA2G12A",0.503070351926785,0.150580586203101,FALSE +"HCC95","Input","KEGG_ALZHEIMERS_DISEASE",0.2159,0.708,0.871,4348,1,"CALML3, NDUFB5, NDUFB7, PPP3R2, NOS1, SNCA, GAPDH, NDUFS6, BAD, ATP5MC1, ATP5PD, PLCB1, NDUFA9, COX5A, ITPR3, NDUFV2, ATP2A3, NDUFB10, CAPN1, NAE1, NDUFA4L2, IL1B, BID, UQCRFS1, ADAM17, SDHD, NDUFA2, ATP2A2, SDHA, MAPK1, NDUFS4, NDUFA8, CDK5, PLCB3, CACNA1D, COX7C",0.0599818449923368,0,FALSE +"HCC95","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.39923,-1.46,0.092,16276,0.358,"PARS2, LARS2, TARS2, FARSA, PSTK, CARS2, YARS2, FARS2",1.03621217265444,0.446116973356126,FALSE +"HCC95","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.33085,-1.21,0.186,16584,0.49,"FPGT, HK2, RENBP, GNE, GMDS, GALE, GMPPA, GALT, PGM1, PMM1, UAP1, NAGK",0.730487055782084,0.309803919971486,FALSE +"HCC95","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.37768,1.22,0.186,2891,0.588,"CAT, NEFL, PPP3R2, CASP1, NOS1, BCL2, NEFM, BAD, MAPK13, DAXX, MAPK12, MAP2K6, BID",0.730487055782084,0.230622673923862,FALSE +"HCC95","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.26382,0.873,0.607,4226,0.886,"CANX, HSP90AB1, HSPA1B, RFXANK, PSME3, TAP2, RFXAP, IFI30, CD8A, KIR2DL3, TAP1, TAPBP, HSPA4, PDIA3",0.216811308924742,0.0525662781129492,FALSE +"HCC95","Input","KEGG_APOPTOSIS",0.23221,0.754,0.811,3028,0.982,"IL1A, IL1RAP, PPP3R2, IKBKB, BCL2, NGF, BAD, PIK3CA, PIK3R2, PRKACA, ENDOD1, ENDOG, CAPN1, TNFSF10, IL1B, BID, PIK3CB",0.090979145788844,0.00788851221305034,FALSE +"HCC95","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.46762,1.53,0.0536,2278,0.496,"CYP4F3, AKR1C3, GPX2, ALOX12B, PTGES2, GPX3, CBR1, EPHX2, CBR3, PLA2G4B, LTC4S, TBXAS1, PLA2G4A, PLA2G12A",1.27083521030723,0.304518323509803,FALSE +"HCC95","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.41436,1.36,0.123,3357,0.496,"GLS2, PYCR2, GLUL, CKMT1B, CKMT1A, NOS1, GOT2, PYCR1, ALDH3A2, ALDH4A1, ASS1, NOS2, GOT1, GAMT, GATM, PYCR3, OAT, CKB, ALDH2",0.910094888560602,0.304518323509803,FALSE +"HCC95","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.18401,0.599,0.976,3704,0.994,"CACNA2D3, CACNG4, JUP, ITGB4, PKP2, ITGA2, LEF1, CACNB1, DSG2, ITGA6, ITGA2B, CDH2, SLC8A1, ATP2A2, GJA1",0.0105501823333082,0.00261361560268669,FALSE +"HCC95","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.43946,-1.58,0.0556,18925,0.456,"ALDH9A1, ALDH7A1",1.25492520841794,0.341035157335565,FALSE +"HCC95","Input","KEGG_ASTHMA",0.23332,0.762,0.807,622,1,"EPX",0.0931264652779296,0,FALSE +"HCC95","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.23195,-0.84,0.656,8962,0.959,"IFNA4, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, IL2, CD28, FASLG, TPO, GZMB, TSHB, CD80, IFNA13, IL4, CTLA4, PRF1, IL10, IFNA21, CGA, IFNA1, IFNA5, TSHR, IL5",0.18309616062434,0.0181813928293364,FALSE +"HCC95","Input","KEGG_AXON_GUIDANCE",0.22644,0.742,0.812,3156,0.986,"PAK2, SEMA4D, RAC3, PPP3R2, EFNB1, SEMA4A, SEMA3F, NTN1, EFNB3, EPHA1, DPYSL5, EPHB4, SEMA4F, PAK6, NCK1, UNC5B, GNAI1, NFATC1, PAK1, ABLIM1, EPHA8, EPHB3, RHOD, EPHB6, MET, SEMA4B, KRAS",0.0904439707588247,0.0061230850587888,FALSE +"HCC95","Input","KEGG_BASAL_CELL_CARCINOMA",0.55164,1.79,0.0188,2279,0.317,"WNT3A, FZD1, WNT5A, WNT8B, GLI2, FZD10, DVL3, WNT10A, SMO, WNT7B, WNT11, WNT10B, FZD9, WNT9A, AXIN1, PTCH1, WNT7A, WNT16, WNT4, LEF1",1.72584215073632,0.498940737782249,FALSE +"HCC95","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.39984,1.31,0.135,5303,0.511,"STON1, TAF6, TAF11, GTF2H4, GTF2F2, TAF4B, GTF2IRD1, GTF2H3, TAF7, TAF5L, TAF6L, GTF2A2, TAF4, TAF9B, GTF2I, TAF1, GTF2H2, GTF2A1L, TAF5",0.869666231504994,0.291579099865287,FALSE +"HCC95","Input","KEGG_BASE_EXCISION_REPAIR",0.37934,1.25,0.18,2468,0.574,"POLB, UNG, PCNA, FEN1, POLE2, POLD2, POLE3, PARP1, HMGB1, NTHL1",0.744727494896694,0.241088107602027,FALSE +"HCC95","Input","KEGG_BETA_ALANINE_METABOLISM",-0.34586,-1.25,0.185,17649,0.506,"DPYD, ACADM, ALDH9A1, SMS, ALDH7A1",0.732828271596986,0.295849483160201,FALSE +"HCC95","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.36381,1.19,0.213,2850,0.633,"TECR, SCD, FADS2, FADS1, HADHA, ELOVL5, SCD5",0.671620396561262,0.198596289982645,FALSE +"HCC95","Input","KEGG_BLADDER_CANCER",-0.25625,-0.939,0.475,16469,0.926,"MDM2, MMP1, RAF1, DAPK3, TYMP, DAPK1, CDKN2A, RASSF1, ARAF",0.323306390375133,0.0333890133180656,FALSE +"HCC95","Input","KEGG_BUTANOATE_METABOLISM",0.33926,1.08,0.299,3522,0.723,"AKR1B10, HMGCS1, EHHADH, ALDH3A2, BDH1, L2HGDH, HADHA, ACAT2, ALDH5A1, OXCT1, ALDH2, GAD1",0.52432881167557,0.140861702705469,FALSE +"HCC95","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.25356,0.849,0.657,3328,0.897,"SYK, RAC3, PPP3R2, IKBKB, PTPN6, GRB2, PIK3CA, PIK3R2, LYN, NFATC1, IFITM1, MALT1, NFKBIB, PIK3CB, KRAS, FOS, HRAS",0.182434630440219,0.0472075569559079,FALSE +"HCC95","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.23852,0.792,0.77,2808,0.968,"CALML3, VDAC3, ADCY3, PPP3R2, NOS1, CHRNA7, VDAC2, ADRA1A, EGFR, PLCB1, PHKB, ADORA2B, ADCY1, GNAL, CAMK4, GNA15, PRKACA, PTAFR, ADRB2, ATP2B4, ITPR3, ATP2A3, CHRM3, PLCD1, TACR1, NOS2, HTR2C",0.113509274827518,0.0141246426916063,FALSE +"HCC95","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.19759,0.65,0.932,5223,0.995,"TNNI3, CACNA2D3, ATP1B3, CACNG4, COX5A, ATP1A1, CACNB1, UQCRFS1, SLC8A1, ATP2A2, CACNA1D, COX7C, MYL2, TPM4, COX5B, CYC1, UQCRHL, UQCRC1, COX8A",0.0305840876460186,0.00217691925427455,FALSE +"HCC95","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.18793,0.621,0.963,3590,0.996,"CLDN8, CLDN11, NECTIN1, CNTN1, SDC1, CDH3, CNTNAP2, JAM3, CLDN4, CLDN7, CDH1, ITGA6, CLDN1, F11R, CD8A, ICOSLG, CDH2, NEO1, CD40",0.0163737128754655,0.00174066157630127,FALSE +"HCC95","Input","KEGG_CELL_CYCLE",0.33735,1.1,0.298,5745,0.707,"YWHAG, MCM7, ANAPC1, CCNB2, SFN, MCM3, CDC6, SKP2, E2F4, TFDP1, ORC3, MCM4, ANAPC11, PCNA, GADD45G, ORC5, MYC, RB1, CDC23, CCND2, CCND3, CDC45, CUL1, RBL1, BUB1, CDC26, TFDP2, CCNA1, PKMYT1, BUB1B, DBF4, CDC14B, CDC25C, STAG1, CCNA2, TGFB2, CHEK1, PTTG1, MAD2L2, ANAPC7, HDAC1, CDC27, SMAD2, CDKN1B, ATR, PTTG2, CCND1, PRKDC, SKP1, CCNB1, TTK, CREBBP, E2F2, PLK1, BUB3, MAD2L1, ANAPC4, MCM6",0.525783735923745,0.150580586203101,FALSE +"HCC95","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.23257,0.76,0.789,3156,1,"GRK7, CXCR2, ADCY3, GRK6, ELMO1, IKBKB, GRB2, GNB2, GNG4, CCL19, CX3CL1, XCL2, PIK3CA, PIK3R2, PLCB1, ADCY1, CCL26, LYN, PRKACA, GNAI1, PAK1, GNB4, NFKBIB, CXCL14, BRAF, GNB5, CXCL16, ARRB2, PIK3CB, KRAS",0.10292299679058,0,FALSE +"HCC95","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.20635,0.677,0.914,4942,1,"IKBKB, GRB2, BAD, PIK3CA, PIK3R2, MYC, RB1, BCR, BRAF, CBLC, PIK3CB, KRAS, HRAS, CRKL, TGFB2, MAPK1, RUNX1, AKT2, HDAC1, MECOM, CDKN1B, TGFBR1, SHC1, CCND1",0.0390538042661686,0,FALSE +"HCC95","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.57348,-2.18,0,15139,0.149,"BHLHE41, CRY1, PER1, NR1D1, NPAS2, CLOCK, CRY2",Inf,0.826813731587726,TRUE +"HCC95","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.35315,-1.23,0.196,17455,0.512,"ACO2, SDHC, PDHB, ACO1, SUCLG1, IDH3G, SUCLG2, PDHA1",0.707743928643524,0.290730039024169,FALSE +"HCC95","Input","KEGG_COLORECTAL_CANCER",0.28377,0.949,0.497,5155,0.83,"RAC3, BCL2, BAD, PIK3CA, PIK3R2, MSH6, AXIN1, MAPK9, MYC, MAPK10, LEF1, BRAF, PIK3CB, KRAS, FOS, TGFB2, BIRC5, MAPK1, MAPK8, AKT2, SMAD2, TGFBR1, CCND1, RAC1, MSH2",0.303643611266668,0.0809219076239261,FALSE +"HCC95","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.1956,-0.702,0.882,11767,1,"C9, C5AR1, C2, SERPINF2, FGB, F2, MASP1, C4BPA, F13A1, CFI, SERPINC1, F7, A2M, FGG, C7, SERPIND1, F10, F5, C3, PLG, CD55, MASP2, SERPINA5, C3AR1, C4BPB, SERPINA1, KLKB1, CD59, PLAUR, SERPING1, F2R, THBD, C4A, C8G, PROS1, C4B, CFB, TFPI",0.0545314148681803,0,FALSE +"HCC95","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.43542,1.44,0.0782,1547,0.499,"APIP, LDHC, GOT2, MAT2B, AHCY, ENOPH1",1.10679324694015,0.30189945437661,FALSE +"HCC95","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.12362,0.41,1,3613,1,"CXCR2, BMP7, FLT4, IL1A, IL1RAP, NGFR, PDGFA, EDAR, CCL19, CX3CL1, EGFR, XCL2, CCL26, IFNLR1, LTB, IL17RA, IL22RA1, TNFSF10, CXCL14, LTBR, IL1B, CXCL16, MET, TNFRSF21, PDGFB, TNFSF18, IL20RB, TNFSF15, IL10RB, CD40, TGFB2",0,0,FALSE +"HCC95","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.18491,-0.677,0.886,18304,1,"TBK1, DDX58, POLR3C, RIPK1",0.0525662781129492,0,FALSE +"HCC95","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.18254,-0.662,0.944,14293,0.981,"TNF, IGF1, ADCY5, CACNG7, SGCD, LAMA2, LMNA, SGCA, TNNC1, CACNB2, DES, RYR2, ITGA9, CACNA2D1, ADCY4, ITGA10, ITGB7, ITGB5, CACNA1C, DMD, CACNA2D4, CACNG6, PRKACB, CACNG8, ITGA7, ITGA1, ITGB3, ITGB1, ADCY6, ACTB, TGFB3, TPM2",0.025028005701931,0.0083309926200515,FALSE +"HCC95","Input","KEGG_DNA_REPLICATION",0.61576,2.06,0.00414,4130,0.479,"RFC4, MCM7, MCM3, RFC2, MCM4, PCNA, RNASEH2B, FEN1, POLE2, POLD2, POLE3, RFC3, RPA3, PRIM1, SSBP1, RPA1, POLA2, RFC5, RNASEH2C, DNA2, PRIM2",2.3829996588791,0.319664486585437,FALSE +"HCC95","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.24456,0.811,0.705,3940,0.936,"GRB2, ETV7, EGFR, KRAS, SPIRE2, MAPK1, NOTCH1",0.151810883008601,0.0287241512618947,FALSE +"HCC95","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.32068,1.05,0.357,2955,0.767,"ADH7, ALDH3A1, UGT2B17, GSTM3, GSTP1, ADH5, GSTA4, GSTA1",0.447331783887807,0.115204636051019,FALSE +"HCC95","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.34161,1.11,0.285,1986,0.744,"GMPS, TPMT, IMPDH1, TK1, UGT2B17, HPRT1, CES1",0.54515513999149,0.128427064454121,FALSE +"HCC95","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.25009,0.822,0.706,3315,0.929,"LAMA1, VWF, CD44, COL4A6, SDC1, ITGB4, LAMC2, ITGA2, SPP1, LAMB3, SV2A, ITGA6, ITGA2B, THBS4, GP1BA, LAMA3",0.151195298948196,0.0319842860063582,FALSE +"HCC95","Input","KEGG_ENDOCYTOSIS",0.25311,0.828,0.689,3027,0.925,"GRK7, TRAF6, CXCR2, FGFR2, GRK6, ACAP2, PRKCI, RAB4A, EPN3, AP2M1, FGFR3, TFRC, MVB12A, GIT1, HSPA1B, SNF8, CHMP6, VPS4B, EGFR, AP2B1, SH3GL3, PIP4K2B, ADRB2, RAB5C, CLTCL1, PLD1, RAB31, RUFY1, RAB11FIP1, ITCH, CHMP1B, CBLC, ARAP3, MET, ARRB2, VPS25",0.161780778092374,0.0338582672609674,FALSE +"HCC95","Input","KEGG_ENDOMETRIAL_CANCER",-0.25355,-0.936,0.549,16363,0.896,"PIK3R3, PIK3R1, SOS1, RAF1, AXIN2, TCF7, TCF7L2, ILK, SOS2, GSK3B, ELK1, ARAF",0.260427655549908,0.0476919903378748,FALSE +"HCC95","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.3968,1.32,0.13,5491,0.504,"CXCR2, ATP6V1C2, PTPRZ1, ATP6V1E2, GIT1, IKBKB, EGFR, JAM3, MAPK13, LYN, MAPK9, PAK1, MAPK10, MAPK12, MET, F11R, ADAM17, HBEGF, ATP6V0A2, TJP1, MAPK8, ATP6V1G2, SRC, MAPK14, MAPK11, ATP6V0C, ATP6V0E2, RAC1, PLCG2, ATP6AP1, CSK, MAP3K14, IKBKG, ADAM10",0.886056647693163,0.297569463554475,FALSE +"HCC95","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.29124,0.962,0.478,4125,0.836,"NRG1, PAK2, NRG4, EIF4EBP1, GRB2, EGFR, BAD, PIK3CA, PIK3R2, PAK6, NCK1, MAPK9, MYC, PAK1, MAPK10, BRAF, CBLC, PIK3CB, KRAS, HBEGF, HRAS, CRKL, NCK2, MAPK1, MAPK8, PAK4, SRC, AKT2, CAMK2G",0.320572103387881,0.0777937225609836,FALSE +"HCC95","Input","KEGG_ETHER_LIPID_METABOLISM",0.30781,0.992,0.419,3292,0.81,"PLA2G4B, PLD1, PLA2G4A, PLA2G12A, PLPP1, PLPP2, PAFAH1B2, LPCAT2",0.377785977033705,0.0915149811213502,FALSE +"HCC95","Input","KEGG_FATTY_ACID_METABOLISM",0.35809,1.17,0.24,3440,0.656,"ADH7, ACSL6, EHHADH, ALDH3A2, ECI1, CPT1A, ACSL3, HADHA, ADH5, ACAT2, ALDH2, HADHB",0.619788758288394,0.18309616062434,FALSE +"HCC95","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.26261,0.862,0.632,4493,0.894,"SYK, RAC3, GRB2, PIK3CA, PIK3R2, PLA2G4B, MAPK13, LYN, MAPK9, PLA2G4A, MAPK10, PLA2G12A, MAPK12, MAP2K6, PIK3CB, KRAS, HRAS, MAPK1, MAPK8, AKT2, MAPK14, MAPK11, VAV2",0.199282921717615,0.0486624812040823,FALSE +"HCC95","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.24326,-0.875,0.593,15255,0.96,"PLCG1, PLPP3, PLA2G4F, AMPH, INPP5D, PIP5K1B, FCGR1A, FCGR2A, PIK3R3, PIK3R1, ARPC3, ARPC4, RAF1, DOCK2, PIP5K1C, PLA2G6, ARF6, CDC42, LAT, PRKCA, ASAP2, CFL2, DNM2, GAB2, PIP5K1A, VASP, DNM1L, MARCKSL1",0.226945306635737,0.0177287669604316,FALSE +"HCC95","Input","KEGG_FOCAL_ADHESION",0.22127,0.726,0.852,4105,0.995,"PDGFD, LAMA1, VWF, PAK2, FLT4, RAC3, COL4A6, CAV1, PDGFA, BCL2, GRB2, CAV2, EGFR, BAD, PIK3CA, PIK3R2, ITGB4, LAMC2, ITGA2, DIAPH1, PAK6, MAPK9, SPP1, LAMB3, PAK1, MAPK10, CCND2, CCND3, BRAF, ITGA6, ITGA2B, MET, PIK3CB, THBS4, PDGFB, MYL12B, LAMA3, HRAS, IGF1R, PPP1CB, CRKL, LAMA5, MAPK1, MAPK8, PAK4, TNC, SRC, AKT2, COL4A1",0.0695604052332999,0.00217691925427455,FALSE +"HCC95","Input","KEGG_FOLATE_BIOSYNTHESIS",0.35829,1.18,0.223,4694,0.645,"DHFR, SPR, GGH",0.651695136951839,0.190440285364732,FALSE +"HCC95","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.36988,1.21,0.188,5217,0.599,"AKR1B10, ALDOC, TPI1, SORD, KHK, MPI, AKR1B1, MTMR1, PFKM, HK1, PFKFB2, MTMR2, ALDOA, FBP2",0.72584215073632,0.222573177610689,FALSE +"HCC95","Input","KEGG_GALACTOSE_METABOLISM",0.26782,0.876,0.626,4310,0.888,"GLA, B4GALT2, GANC, AKR1B1, GAA, GCK, PFKM, GALK2, HK1",0.20342566678957,0.051587034221399,FALSE +"HCC95","Input","KEGG_GAP_JUNCTION",0.25971,0.855,0.641,4826,0.892,"PDGFD, ADCY3, PDGFA, GRB2, EGFR, PLCB1, ADCY1, PRKACA, GNAI1, ITPR3, HTR2C, LPAR1, TUBAL3, KRAS, PDGFB, HRAS, TUBA4A, MAP2K5, GJA1, TJP1, MAPK1, SRC, PLCB3, TUBB, PDGFC, GUCY1B1, ADCY9",0.193141970481183,0.0496351456238769,FALSE +"HCC95","Input","KEGG_GLIOMA",0.22471,0.736,0.855,4125,0.988,"CALML3, PDGFA, GRB2, EGFR, PIK3CA, PIK3R2, RB1, BRAF, PIK3CB, KRAS, PDGFB, HRAS, IGF1R, MAPK1, AKT2, CAMK2G",0.0680338852718274,0.00524305541237188,FALSE +"HCC95","Input","KEGG_GLUTATHIONE_METABOLISM",0.44028,1.43,0.0848,1394,0.499,"GCLC, GCLM, PGD, GPX2, GSR, G6PD, GPX3, GGCT, GSTM3",1.07160414774329,0.30189945437661,FALSE +"HCC95","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.24477,-0.87,0.575,18025,0.94,"AGPAT4, LIPG, GK, MGLL, ALDH9A1, ALDH7A1",0.24033215531037,0.0268721464003014,FALSE +"HCC95","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.41499,1.33,0.134,3494,0.526,"LPCAT3, DGKH, LCLAT1, PTDSS1, PCYT1A, GNPAT, PCYT2, PCYT1B, PLA2G4B, DGKE, PLD1, PLA2G4A, PLA2G12A, ETNK2, PEMT, PLPP1, CDS1, ETNK1, CDIPT, PLPP2, PGS1, CDS2, AGPAT3, LPCAT2, GPD2, DGKA",0.872895201635192,0.279014255846261,FALSE +"HCC95","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.42973,1.4,0.085,3249,0.483,"GNMT, AOC2, PIPOX, PSAT1, SHMT1, AOC3, GAMT, GATM, PHGDH, GCAT",1.07058107428571,0.316052869248488,FALSE +"HCC95","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.39925,1.33,0.107,4582,0.526,"ADH7, LDHC, ALDH3A1, ALDOC, TPI1, GAPDH, ACSS1, GPI, ALDH3A2, BPGM, ACSS2, ADH5, DLAT, PGAM4, ALDH2, LDHB, ALDH1A3, PGAM1, GCK, PFKM, HK1, PKM, PCK2",0.97061622231479,0.279014255846261,FALSE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.36743,1.22,0.211,5286,0.588,"B4GALT7, XYLT2, CHST14, CHST7, CHST15, B3GAT3, CHPF, CHSY1, CHST3, CHST12, B3GALT6",0.675717544702307,0.230622673923862,FALSE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.47807,1.56,0.0393,3874,0.503,"HS6ST1, B4GALT7, XYLT2, HS6ST2, HS3ST3B1, GLCE, NDST2, B3GAT3, NDST1, HS3ST3A1",1.40560744962457,0.298432014944073,FALSE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.56397,-2,0.0115,14254,0.193,"ST3GAL3, CHST4, CHST2, CHST6, B3GNT7, FUT8, B4GALT4, B4GALT3, ST3GAL1",1.93930215964639,0.714442690992226,TRUE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.38633,1.26,0.166,2073,0.564,"HPSE, HGSNAT, HS3ST3B1, HEXB, NAGLU",0.779891911959945,0.248720896016658,FALSE +"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.44391,1.48,0.0688,2469,0.515,"SLC33A1, B4GALNT1, B3GALT4, HEXB, ST6GALNAC4",1.16241156176449,0.288192770958809,FALSE +"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.2793,0.913,0.579,1845,0.863,"GLA, FUT1, HEXB",0.237321436272564,0.0639892042847904,FALSE +"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.33183,-1.22,0.184,14254,0.5,"ST3GAL3, B3GALT2, FUT7, FUT9, FUT3, FUT4, B3GALT1, B3GALT5, ST3GAL6, B3GNT3, B4GALT4, B4GALT3",0.735182176990464,0.301029995663981,FALSE +"HCC95","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.56763,1.87,0.0119,788,0.367,"PIGX, PIGS, PIGW, PIGU, PIGV, PIGN",1.92445303860747,0.435333935747911,FALSE +"HCC95","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.32728,-1.2,0.192,17087,0.483,"GLYCTK, ACO2, ACO1, MTHFD2L, HYI",0.71669877129645,0.316052869248488,FALSE +"HCC95","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.28819,0.938,0.522,4347,0.848,"CALML3, ADCY3, GRB2, EGFR, PLA2G4B, MAPK13, PLCB1, ADCY1, MAPK9, PRKACA, PLD1, ITPR3, PLA2G4A, MAPK10, PLA2G12A, MAPK12, MAP2K6, KRAS, HBEGF, HRAS, MMP14, MAPK1, MAPK8, SRC, CAMK2G, PLCB3, MAPK14, CACNA1D, ATF4, MAPK11",0.282329496997738,0.0716041477432862,FALSE +"HCC95","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.32068,1.06,0.345,4253,0.753,"IL1A, IL1B, KIR2DL3, CD86",0.462180904926726,0.123205023799299,FALSE +"HCC95","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.55523,1.82,0.024,2277,0.382,"WNT3A, BMP7, WNT5A, WNT8B, GLI2, WNT10A, SMO, WNT7B, WNT11, FBXW11, WNT10B, WNT9A, PTCH1, WNT7A, WNT16, PRKACA, WNT4, CSNK1A1",1.61978875828839,0.417936637088291,FALSE +"HCC95","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.19165,0.63,0.961,3166,0.996,"CD44, IL1A, CD1D, TFRC, CD9, ITGA2, ITGA6, IL1B, CD1E, ITGA2B, CD8A, GP1BA",0.0172766123314547,0.00174066157630127,FALSE +"HCC95","Input","KEGG_HISTIDINE_METABOLISM",0.2761,0.914,0.542,1399,0.88,"ALDH3A1, BUD23, METTL2B, ALDH3A2",0.266000713461613,0.0555173278498314,FALSE +"HCC95","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.46057,1.52,0.0604,3916,0.458,"SEM1, RAD51, EME1, POLD2, XRCC3, RPA3, BLM, SSBP1, RPA1, RAD51B, RAD51C, RAD51D, XRCC2",1.21896306137887,0.339134521996131,FALSE +"HCC95","Input","KEGG_HUNTINGTONS_DISEASE",0.20404,0.654,0.936,2542,1,"HAP1, VDAC3, POLR2H, NDUFB5, NDUFB7, POLR2J, AP2M1, VDAC2, NRF1, NDUFS6, AP2B1, ATP5MC1, ATP5PD, PLCB1, POLR2G, NDUFA9, SIN3A, COX5A, TAF4B, CLTCL1, NDUFV2, NDUFB10, NDUFA4L2",0.0287241512618947,0,FALSE +"HCC95","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.21308,-0.765,0.817,14891,1,"SGCD, LAMA2, LMNA, SGCA, PRKAB1, TNNC1, CACNB2, DES, RYR2, ITGA9, CACNA2D1, ITGA10, ITGB7, ITGB5, CACNA1C, DMD, CACNA2D4, CACNG6, CACNG8, PRKAA2, ITGA7, ITGA1, ACE, ITGB3, ITGB1, ACTB, TGFB3, TPM2",0.0877779434675845,0,FALSE +"HCC95","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.21705,-0.782,0.737,17006,1,"ALDH6A1, PIK3C2A, PIP5K1C, PI4KA, SYNJ1, INPPL1, PIK3C3, PIP4K2A, PIP5K1A, PI4KB",0.132532512140949,0,FALSE +"HCC95","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.29416,0.964,0.478,4615,0.841,"CALML3, PRKCI, ACACA, EIF4EBP1, IKBKB, GRB2, SREBF1, BAD, PIK3CA, PIK3R2, PHKB, IRS1, MAPK9, PRKACA, SOCS1, MAPK10, FLOT2, SLC2A4, FOXO1, RHEB, BRAF, PRKAA1, CBLC, FASN, PIK3CB, KRAS, EXOC7, HRAS, PHKA1, ACACB, PPP1CB, CRKL, PRKAG2, SH2B2, RPTOR, MAPK1, MAPK8, GCK, AKT2, PYGL, HK1, PRKCZ, PTPN1, PCK2, RAPGEF1",0.320572103387881,0.0752040042020878,FALSE +"HCC95","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.18783,-0.68,0.928,11300,1,"CD80, PIGR, TNFSF13, IL4, AICDA, IL10, CCR9, CCL25, TNFRSF13C, IL6, CXCL12, IL5, CCR10, ITGB7, TNFSF13B, CXCR4, IL15, CCL28",0.0324520237811379,0,FALSE +"HCC95","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.20593,-0.743,0.853,16363,1,"PIK3R3, PIK3R1, CSF2RA, IL3RA, CNTF, SOS1, IL15, IL11RA, STAT1, IL6ST, PIAS3, SPRY4, JAK2, LIF, SPRY2, SPRY3, IL11, STAM, JAK1, SOCS4, CLCF1, TYK2, IRF9, SOS2, STAT2, STAT5A",0.069050968832477,0,FALSE +"HCC95","Input","KEGG_LEISHMANIA_INFECTION",0.24501,0.791,0.749,4896,0.961,"TRAF6, IL1A, PTPN6, MAPK13, MAPK12, NFKBIB, NOS2, IL1B, MAP3K7, FOS, TGFB2, MAPK1, MAPK14, PTGS2, MAPK11, NCF2, IL12A, ITGB2",0.125518182300534,0.0172766123314547,FALSE +"HCC95","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.2144,-0.769,0.789,13995,1,"ESAM, VAV3, VCL, CXCL12, CLDN14, CTNNA2, CLDN2, CDH5, MYL5, ARHGAP5, CLDN15, VCAM1, PRKCG, RAPGEF3, PLCG1, CLDN10, JAM2, CYBB, PIK3R3, PIK3R1, CXCR4, CLDN9, GNAI3, RHOA, MYLPF, ROCK1, AFDN, EZR, TXK, CD99, CDC42, ITGB1, CLDN23, ACTB, PRKCA, BCAR1, RAP1B, RAP1A, MYL9, ICAM1, ROCK2, VASP, CYBA",0.10292299679058,0,FALSE +"HCC95","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.45478,-1.61,0.046,18062,0.507,"YOD1, ALDH9A1, ALDH7A1",1.33724216831843,0.294992040666664,FALSE +"HCC95","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.27548,0.895,0.593,2278,0.861,"AKR1B10, PLA2G4B, PLA2G4A, PLA2G12A",0.226945306635737,0.0649968485463452,FALSE +"HCC95","Input","KEGG_LONG_TERM_DEPRESSION",0.22976,0.757,0.805,3896,0.993,"PPP2CA, NOS1, GNA13, PLA2G4B, PLCB1, LYN, GNAI1, ITPR3, PLA2G4A, PLA2G12A, BRAF, KRAS, HRAS, IGF1R, GNAZ, MAPK1, PPP2R1B",0.0942041196321315,0.00305075150461883,FALSE +"HCC95","Input","KEGG_LONG_TERM_POTENTIATION",0.20946,0.678,0.899,4481,1,"CALML3, PPP3R2, PLCB1, ADCY1, CAMK4, PRKACA, ITPR3, RPS6KA1, BRAF, KRAS, HRAS, PPP1CB, MAPK1, CAMK2G, PLCB3, ATF4, CHP1",0.0462403082667712,0,FALSE +"HCC95","Input","KEGG_LYSINE_DEGRADATION",0.2755,0.898,0.57,3357,0.872,"NSD3, EHHADH, PIPOX, ALDH3A2, NSD1, HADHA, EHMT2, NSD2, ACAT2, SETDB2, ALDH2",0.244125144327509,0.0594835150674328,FALSE +"HCC95","Input","KEGG_LYSOSOME",0.21187,0.695,0.867,5662,1,"PSAPL1, AP3M2, SLC11A1, M6PR, ARSG, CTSV, LAMP3, AP3B1, GLA, HGSNAT, AP1S1, HEXB, LIPA, NAGLU, CLTCL1, GM2A, CD68, NAGPA, CTSH, AP3B2, GNPTAB, LAMP1, CLN5, AP3M1, PPT1, ATP6V0A2, AP1S3, NPC1, GAA, DNASE2, AP1M2, ATP6V0C, LAPTM4B, ABCA2, CTSZ, HEXA, NAGA, GGA2, CLTB, ATP6AP1, NPC2, CTSB, CLTC, PPT2, CTSF, LGMN, CTSL",0.0619809025237897,0,FALSE +"HCC95","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.27399,0.895,0.589,3498,0.861,"TRAF6, NTRK2, MAP3K13, MAP4K1, PAK2, NTF4, FGFR2, RAC3, IL1A, CACNA2D3, NF1, HSPB1, PPP3R2, NLK, FGFR3, IKBKB, PDGFA, DUSP14, GRB2, HSPA1B, NGF, CACNG4, EGFR, PLA2G4B, MAPK13, GADD45G, MAPK9, PPM1B, PRKACA, MYC, PAK1, PLA2G4A, FGF1, MAPK10, PLA2G12A, SRF, CACNB1, DAXX, MAPK12, MAP2K6, DUSP9, RPS6KA1, BRAF, FGF12, DUSP3, IL1B, JUND, ARRB2, MAP3K7, RPS6KA5, CACNA1B, KRAS, PDGFB, FOS, HRAS, TAOK1, RPS6KA4, MAP2K5, CRKL",0.229884705212898,0.0649968485463452,FALSE +"HCC95","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26424,0.856,0.651,4735,0.898,"MAFA, ONECUT1, HHEX, MNX1, GCK, FOXA2, HES1",0.186419011431808,0.0467236633326956,FALSE +"HCC95","Input","KEGG_MELANOGENESIS",0.43383,1.42,0.0877,2279,0.499,"CALML3, WNT3A, FZD1, ADCY3, WNT5A, WNT8B, FZD10, DVL3, WNT10A, POMC, WNT7B, EDN1, WNT11, WNT10B, FZD9, PLCB1, WNT9A, ADCY1, WNT7A, WNT16, PRKACA, GNAI1, WNT4, LEF1",1.05700040663396,0.30189945437661,FALSE +"HCC95","Input","KEGG_MELANOMA",0.27659,0.911,0.558,3418,0.849,"PDGFD, PDGFA, EGFR, BAD, PIK3CA, PIK3R2, RB1, FGF1, CDH1, BRAF, FGF12, MET, PIK3CB, KRAS, PDGFB, HRAS, IGF1R",0.253365801062421,0.0710923097560473,FALSE +"HCC95","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.53409,1.74,0.0228,1394,0.364,"ADH7, AKR1C2, ALDH3A1, AKR1C1, DHDH, AKR1C3, CYP2S1, CYP1B1, EPHX1, UGT2B17, GSTM3",1.64206515299955,0.438898616350944,FALSE +"HCC95","Input","KEGG_MISMATCH_REPAIR",0.58449,1.94,0.00923,4009,0.495,"RFC4, RFC2, PMS2, MSH6, PCNA, POLD2, RFC3, RPA3, SSBP1, RPA1, RFC5, EXO1",2.03479829897409,0.305394801066431,FALSE +"HCC95","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.30304,0.988,0.413,4169,0.81,"EIF4EBP1, DDIT4, PIK3CA, PIK3R2, ULK2, RHEB, RPS6KA1, BRAF, PRKAA1, PIK3CB, EIF4B, RPTOR, MAPK1, AKT2, MLST8",0.384049948343599,0.0915149811213502,FALSE +"HCC95","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.1681,0.541,0.996,3348,1,"SYK, RAC3, PPP3R2, ULBP1, MICB, PTPN6, GRB2, PIK3CA, PIK3R2, NFATC1, PAK1, MICA, TNFSF10, BRAF, LCK, BID, PIK3CB, KRAS, KIR2DL3, HRAS, ULBP3",0.00174066157630127,0,FALSE +"HCC95","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.13459,0.436,1,2847,1,"P2RY1, ADRA2C, GABRB3, S1PR5, CHRNA7, CHRNB4, ADRA1A, CHRNA5, SSTR5, VIPR1, LPAR2, ADORA2B, PTAFR, ADRB2, MTNR1A, GRM4, P2RY13, CHRM3, TACR1, P2RY2, LPAR6, PTH2R, HTR2C, NMUR2, F2RL2, LPAR1",0,0,FALSE +"HCC95","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.32583,1.07,0.344,4347,0.739,"CALML3, TRAF6, NTRK2, NTF4, YWHAG, NGFR, TP73, IKBKB, BCL2, GRB2, NGF, BAD, PIK3CA, PIK3R2, MAPK13, IRS1, CAMK4, MAPK9, MAPK10, MAPK12, NFKBIB, RPS6KA1, BRAF, PIK3CB, RPS6KA5, KRAS, HRAS, RPS6KA4, MAP2K5, CRKL, SH2B2, MAPK1, MAPK8, AKT2, CAMK2G, MAPK14, ATF4, MAPK11",0.46344155742847,0.131355561605174,FALSE +"HCC95","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.37484,-1.35,0.124,16890,0.484,"AOX1, NMNAT2, NMNAT1, NT5E, NNT, NNMT, QPRT",0.906578314837765,0.315154638355588,FALSE +"HCC95","Input","KEGG_NITROGEN_METABOLISM",0.38858,1.29,0.122,1305,0.54,"GLS2, GLUL, ASNS",0.913640169325252,0.267606240177031,FALSE +"HCC95","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.33633,1.09,0.298,4347,0.709,"TRAF6, HSP90AB1, CASP1, IKBKB, MAPK13, MAPK9, MAPK10, TRIP6, MAPK12, NFKBIB, IL1B, PYCARD, MAP3K7, MAPK1, MAPK8, SUGT1, IL18, MAPK14, MAPK11",0.525783735923745,0.149353764816933,FALSE +"HCC95","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.40163,-1.46,0.0733,16335,0.358,"POLM, RAD50, NHEJ1, DCLRE1C, LIG4",1.13489602535887,0.446116973356126,FALSE +"HCC95","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.20338,-0.737,0.867,14914,1,"MAP2K2, PRKCG, PLCG1, TP53, E2F3, PIK3R3, PIK3R1, SOS1, RAF1, FHIT, PRKCA, CDKN2A, SOS2, RASSF1, ARAF",0.0619809025237897,0,FALSE +"HCC95","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.23284,0.757,0.793,4735,0.993,"DLL1, DVL3, JAG2, MAML1, KAT2A, DLL3, JAG1, DVL2, DTX2, ADAM17, NOTCH1, HDAC1, MFNG, NUMBL, LFNG, HES1",0.100726812682396,0.00305075150461883,FALSE +"HCC95","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.42598,1.4,0.097,3688,0.483,"RFC4, RAD23B, RFC2, GTF2H4, PCNA, POLE2, XPA, POLD2, POLE3, RFC3, RPA3, GTF2H3, RPA1, ERCC3, ERCC8, RFC5",1.01322826573376,0.316052869248488,FALSE +"HCC95","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.42909,1.4,0.0901,4377,0.483,"ALG3, ALG12, MOGS, DOLPP1, MGAT1, B4GALT2, TUSC3, ALG2, ALG1, ALG14, DPAGT1, GANAB, DPM1, STT3A, RFT1, MGAT4B, ALG5, ALG11, MAN1B1, ALG10B, MGAT2, RPN2",1.04527520902094,0.316052869248488,FALSE +"HCC95","Input","KEGG_OLFACTORY_TRANSDUCTION",0.33325,1.1,0.305,458,0.707,"OR10S1, CALML3, OR11H4, OR8A1, OR8G1, OR1G1, OR10H2, OR8D2, OR6C70, ADCY3, OR8G5",0.515700160653214,0.150580586203101,FALSE +"HCC95","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.30475,0.998,0.407,5546,0.816,"MTFMT, TYMS, SHMT1, DHFR, MTHFD2, SHMT2, MTHFD1L, GART, MTHFD1",0.39040559077478,0.0883098412461389,FALSE +"HCC95","Input","KEGG_OOCYTE_MEIOSIS",0.26634,0.868,0.637,4187,0.888,"CALML3, ADCY3, YWHAG, PPP3R2, ANAPC1, PPP2CA, CCNB2, FBXW11, PPP2R5D, ANAPC11, ADCY1, PRKACA, ITPR3, CDC23, MAPK12, CUL1, RPS6KA1, BUB1, CDC26, PKMYT1, CDC25C, IGF1R, PPP1CB, PTTG1, MAD2L2, MAPK1, PPP2R1B, CAMK2G, ANAPC7",0.19586056766465,0.051587034221399,FALSE +"HCC95","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.34108,-1.25,0.175,13292,0.506,"FUCA2, MAN2C1, NEU4, GLB1, FUCA1, NEU1, GBA, AGA, MAN2B1, MANBA",0.756961951313706,0.295849483160201,FALSE +"HCC95","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.20225,0.651,0.934,6278,1,"ATP6V1C2, ATP6V1E2, NDUFB5, NDUFB7, NDUFS6, ATP5MC1, ATP5PD, NDUFA9, COX5A, NDUFV2, NDUFB10, NDUFA4L2, COX10, COX11, LHPP, UQCRFS1, SDHD, NDUFA2, ATP6V0A2, ATP5MG, SDHA, ATP6V1G2, NDUFS4, NDUFA8, COX7C, ATP6V0C, COX5B, ATP6V0E2, CYC1, UQCRHL, NDUFV1, ATP5PO, UQCRC1, COX8A, ATP6AP1, ATP5F1A, NDUFA10, UQCRQ, PPA1, NDUFB8, ATP12A, ATP5MF, COX15, NDUFB9, NDUFB2, COX7A2L, ATP6V0A1, ATP5MC3",0.0296531237699066,0,FALSE +"HCC95","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.35234,1.15,0.241,2264,0.68,"GCNT1, GALNT11, GALNT18, GALNT13, GALNT14, GALNT12",0.617982957425132,0.167491087293764,FALSE +"HCC95","Input","KEGG_P53_SIGNALING_PATHWAY",0.31099,1.01,0.406,977,0.804,"TP53AIP1, SESN3, SERPINB5, TP73, EI24, CCNB2, SFN",0.391473966422806,0.0947439512515487,FALSE +"HCC95","Input","KEGG_PANCREATIC_CANCER",0.28446,0.934,0.527,5488,0.848,"RAC3, IKBKB, RALBP1, RAD51, EGFR, BAD, PIK3CA, PIK3R2, MAPK9, PLD1, RB1, MAPK10, BRAF, PIK3CB, KRAS, TGFB2, MAPK1, MAPK8, AKT2, SMAD2, TGFBR1, TGFA, CCND1, RAC1, ERBB2, VEGFC, IKBKG, E2F2",0.278189384787453,0.0716041477432862,FALSE +"HCC95","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.3738,1.23,0.181,3596,0.605,"COASY, PANK2, PPCDC, PANK3, BCAT1, BCAT2",0.742321425130815,0.218244625347531,FALSE +"HCC95","Input","KEGG_PARKINSONS_DISEASE",0.19697,0.645,0.961,2542,0.992,"VDAC3, SNCAIP, NDUFB5, NDUFB7, SNCA, VDAC2, NDUFS6, ATP5MC1, ATP5PD, UCHL1, NDUFA9, COX5A, NDUFV2, NDUFB10, NDUFA4L2",0.0172766123314547,0.00348832784582135,FALSE +"HCC95","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.41106,-1.49,0.0615,16465,0.455,"YWHAQ, ARPC3, CD14, RHOA, ARPC4, TLR4, TUBA1A, ROCK1, EZR, TUBA8, CDC42, ITGB1, ACTB, PRKCA, TUBB2B, TUBB2A, ROCK2, ARHGEF2",1.21112488422458,0.341988603342888,FALSE +"HCC95","Input","KEGG_PATHWAYS_IN_CANCER",0.30119,0.999,0.434,3708,0.824,"TRAF6, WNT3A, LAMA1, FZD1, FGFR2, RAC3, WNT5A, WNT8B, GLI2, COL4A6, FZD10, DVL3, WNT10A, HSP90AB1, SMO, WNT7B, FGFR3, IKBKB, WNT11, PDGFA, BCL2, GRB2, RALBP1, SKP2, RAD51, WNT10B, EGFR, BAD, PIK3CA, JUP, RXRA, PIK3R2, FZD9, LAMC2, WNT9A, MSH6, AXIN1, ITGA2, PTCH1, WNT7A, WNT16, MAPK9, CEBPA, MYC, LAMB3, PLD1, WNT4, RB1, FGF1, MAPK10, LEF1, GSTP1, FOXO1, CDH1, BCR, BRAF, FGF12, ITGA6, NOS2, CBLC, FZD6, BID, ITGA2B, MET, SLC2A1, PIK3CB, CCNA1, DVL2, KRAS, PDGFB, PML, FOS, TRAF4, LAMA3, HRAS, IGF1R, CRKL, ARNT2, TGFB2, BIRC5, LAMA5, EGLN3",0.362510270487489,0.0840727883028842,FALSE +"HCC95","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.46084,1.52,0.0439,4360,0.458,"DHDH, DCXR, UGT2B17, AKR1B1, UGDH, RPEL1",1.35753547975788,0.339134521996131,FALSE +"HCC95","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.50449,1.65,0.0257,1720,0.435,"ALDOC, PGD, G6PD, TKT, TALDO1, GPI, PGLS, DERA",1.59006687666871,0.361510743045363,FALSE +"HCC95","Input","KEGG_PEROXISOME",0.33945,1.11,0.267,2716,0.744,"CAT, ACSL6, PEX6, EHHADH, GNPAT, PRDX1, SLC27A2, PEX11G, PEX5, PIPOX, PXMP2, EPHX2, PEX2, PAOX, PEX10, ACSL3, CROT, NOS2",0.573488738635425,0.128427064454121,FALSE +"HCC95","Input","KEGG_PHENYLALANINE_METABOLISM",0.44089,1.44,0.0735,2780,0.499,"ALDH3A1, AOC2, GOT2, AOC3, GOT1",1.1337126609158,0.30189945437661,FALSE +"HCC95","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25236,0.813,0.714,3123,0.941,"CALML3, DGKH, PIK3CA, PIK3R2, PLCB1, DGKE, PIP4K2B, IMPA2, ITPR3, IPPK, PLCD1, CDS1, CDIPT, PIK3CB, CDS2",0.146301788223826,0.0264103765727431,FALSE +"HCC95","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.25238,-0.902,0.535,18193,0.92,"CPOX, UROD, HMOX1, PPOX, HCCS",0.271646217978772,0.0362121726544447,FALSE +"HCC95","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.31381,1.02,0.409,3022,0.813,"ACSL6, ME1, SCD, EHHADH, FADS2, OLR1, SLC27A2, PLTP, RXRA, CPT1A, SLC27A5, ACSL3, FABP6, SCD5, SLC27A6",0.388276691992658,0.0899094544059319,FALSE +"HCC95","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.42226,-1.5,0.0747,15755,0.513,"CYP46A1, CYP7B1, CYP27A1, ACOX2, HSD3B7, SCP2",1.1266793981846,0.289882634888184,FALSE +"HCC95","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.54243,1.8,0.00985,3590,0.354,"RAG1, RAG2, RFXANK, UNG, ADA, TAP2, RFXAP, LCK, CD8A, TAP1, CD40",2.00656376950239,0.450996737974212,FALSE +"HCC95","Input","KEGG_PRION_DISEASES",-0.19563,-0.731,0.862,15964,1,"NCAM2, CCL5, PRKACB, NCAM1, C8G, HSPA1A, ELK1",0.0644927341752872,0,FALSE +"HCC95","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.35234,1.15,0.264,4415,0.68,"ADCY3, HSP90AB1, ANAPC1, CCNB2, PIK3CA, PIK3R2, MAPK13, ANAPC11, ADCY1, MAPK9, PRKACA, GNAI1, MAPK10, CDC23, MAPK12, RPS6KA1, BRAF, BUB1, PIK3CB, CDC26, CCNA1, PKMYT1, KRAS, CDC25C, IGF1R, CCNA2, MAD2L2, MAPK1, MAPK8, AKT2, ANAPC7, MAPK14, MAPK11, CDC27",0.578396073130169,0.167491087293764,FALSE +"HCC95","Input","KEGG_PROPANOATE_METABOLISM",0.31198,1.02,0.403,3769,0.813,"LDHC, EHHADH, ACACA, ACSS1, ALDH3A2, PCCB, ACSS2, HADHA, ACAT2, ALDH2, ACACB, LDHB",0.39469495385889,0.0899094544059319,FALSE +"HCC95","Input","KEGG_PROSTATE_CANCER",0.28298,0.924,0.553,3418,0.864,"PDGFD, FGFR2, HSP90AB1, IKBKB, PDGFA, BCL2, GRB2, EGFR, BAD, PIK3CA, PIK3R2, RB1, LEF1, GSTP1, FOXO1, BRAF, PIK3CB, KRAS, PDGFB, HRAS, IGF1R",0.257274868695302,0.0634862575211067,FALSE +"HCC95","Input","KEGG_PROTEASOME",0.41552,1.36,0.132,5428,0.496,"PSMD11, PSMD2, SEM1, PSME3, PSMC5, PSMD12, PSMD3, PSMC2, PSMA4, PSMB3, PSMD8, PSMF1, PSME4, PSMC1, PSMB9, PSMA7, PSMB6, PSMB8, PSMB10, PSMA2, PSMD7",0.87942606879415,0.304518323509803,FALSE +"HCC95","Input","KEGG_PROTEIN_EXPORT",-0.29128,-1.08,0.312,17904,0.663,"SRPRB, SEC61A2, SEC63, SEC61A1",0.505845405981557,0.178486471595227,FALSE +"HCC95","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.47173,1.54,0.0568,2389,0.51,"GLS2, SLC9A3, ATP1B3, SLC25A10, MDH1, ATP1A1",1.24565166428898,0.292429823902064,FALSE +"HCC95","Input","KEGG_PURINE_METABOLISM",0.23092,0.754,0.809,5795,0.982,"ADCY10, POLR2H, GMPS, ADCY3, IMPDH1, NME2, POLR2J, POLR1D, ADA, ADK, AK7, ADCY1, POLR2G, HPRT1, POLE2, POLD2, POLE3, POLR3G, PRIM1, PAICS, NT5C, POLR1B, POLA2, POLR2D, PDE8B, NT5M, PFAS, ITPA, PRIM2, ENTPD2, PKM, PDE9A, POLR3F, NME3, GUCY1B1, POLR2J2, ADCY9, NME1, ENTPD6, POLR1C, POLR2I, PPAT, POLD1, POLR2C, GART, CANT1, POLD3, POLR3GL, POLR2F, RRM1, AK4",0.0920514783877277,0.00788851221305034,FALSE +"HCC95","Input","KEGG_PYRIMIDINE_METABOLISM",0.27634,0.911,0.572,5758,0.849,"POLR2H, TK1, NME2, POLR2J, POLR1D, TXNRD1, TYMS, POLR2G, CAD, POLE2, POLD2, POLE3, POLR3G, DUT, PRIM1, NT5C, POLR1B, POLA2, POLR2D, NT5M, DTYMK, ITPA, PRIM2, DHODH, POLR3F, UPP1, NME3, POLR2J2, NME1, ENTPD6, POLR1C, POLR2I, POLD1, POLR2C, DCTD, CANT1, POLD3, POLR3GL, POLR2F, RRM1",0.242603971206976,0.0710923097560473,FALSE +"HCC95","Input","KEGG_PYRUVATE_METABOLISM",0.33581,1.1,0.302,3776,0.707,"LDHC, ME1, ACACA, ACSS1, ALDH3A2, MDH2, MDH1, ACSS2, DLAT, ACAT2, AKR1B1, ALDH2, ACACB, LDHB, GLO1",0.519993057042849,0.150580586203101,FALSE +"HCC95","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.19717,0.65,0.932,5149,0.995,"PDGFD, PAK2, FGFR2, RAC3, FGFR3, GIT1, FGD3, ENAH, PDGFA, GNA13, PFN2, EGFR, ARPC2, PIK3CA, PIK3R2, ITGB4, ITGA2, PIP4K2B, DIAPH1, PAK6, PAK1, FGF1, CHRM3, BRAF, FGF12, ITGA6, MYH14, ITGA2B, PIK3CB, KRAS, PDGFB, MYL12B, CYFIP1, HRAS, PPP1CB, CRKL, IQGAP2, SSH1, BDKRB2, MAPK1, PAK4, MSN, LIMK1, BDKRB1, MYL2, VAV2, PFN4, ARHGEF4, PDGFC, ITGB8, ITGAE, BAIAP2, ITGB2, FGFR4, ITGA3, SSH3, RAC1, ARHGAP35, MYH10, ITGB6",0.0305840876460186,0.00217691925427455,FALSE +"HCC95","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.35227,-1.31,0.143,16573,0.472,"ATG4C, PRKAA2, ATG4A, ULK3, GABARAP, ATG7, ATG4B, PIK3C3, PIK3R4, ATG3",0.844663962534938,0.326058001365912,FALSE +"HCC95","Input","KEGG_RENAL_CELL_CARCINOMA",0.22785,0.746,0.83,4107,0.988,"PAK2, GRB2, PIK3CA, PIK3R2, PAK6, PAK1, BRAF, MET, SLC2A1, PIK3CB, KRAS, PDGFB, HRAS, CRKL, ARNT2, TGFB2, EGLN3, MAPK1, PAK4, AKT2, ELOC",0.0809219076239261,0.00524305541237188,FALSE +"HCC95","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.34171,1.14,0.257,2098,0.693,"CMA1, NLN, LNPEP",0.590066876668705,0.159266765388193,FALSE +"HCC95","Input","KEGG_RETINOL_METABOLISM",0.42286,1.38,0.0989,197,0.506,"ADH7, RDH16, CYP26A1",1.00480370840282,0.295849483160201,FALSE +"HCC95","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.40067,-1.47,0.0902,14086,0.432,"FLAD1, ACP4, PHPT1, ACP5, ACP2, ACP1",1.04479346245806,0.364516253185088,FALSE +"HCC95","Input","KEGG_RIBOSOME",0.40256,1.32,0.132,4872,0.504,"RPL35A, RPS2, RPL12, RPLP1, RPL38, RPS17, RPL37, RPL13, RPL18A, RPS10, RPL23A, RPL27, RPL26L1, RPL22, RPS21, RPS16, RPL31, RPL22L1, RSL24D1, RPL26, RPL23, RPS18, RPL4, RPL8, RPL17, RPL19, RPS27A, RPL21, RPL7A, RPL10A, RPL3L, RPL35, FAU, RPS24, RPS23, UBA52, RPLP0, RPS3",0.87942606879415,0.297569463554475,FALSE +"HCC95","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.21245,0.694,0.894,4347,1,"TRAF6, IKBKB, MAPK13, MAPK9, MAPK10, NLRX1, MAPK12, NFKBIB, TKFC, MAVS, MAP3K7, ATG5, MAPK8, TRADD, MAPK14, MAPK11",0.0486624812040823,0,FALSE +"HCC95","Input","KEGG_RNA_DEGRADATION",0.31295,1.01,0.405,3669,0.804,"LSM1, LSM4, LSM2, CNOT6, CNOT1, EXOSC8, EDC3, TENT4A, EXOSC2, EXOSC1, CNOT8, WDR61, HSPA9, XRN2, DCP2, LSM6, CNOT9",0.392544976785331,0.0947439512515487,FALSE +"HCC95","Input","KEGG_RNA_POLYMERASE",0.41478,1.37,0.0984,5730,0.508,"POLR2H, POLR2J, POLR1D, POLR2G, POLR3G, POLR1B, POLR2D, POLR3F, POLR2J2, POLR1C, POLR2I, POLR2C, POLR3GL, POLR2F",1.00700490156866,0.294136287716081,FALSE +"HCC95","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.38287,1.26,0.165,1510,0.564,"BUD23, METTL2B, MAT2B, AHCY",0.782516055786094,0.248720896016658,FALSE +"HCC95","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.33346,1.1,0.303,5488,0.707,"TRAF6, LAMA1, COL4A6, IKBKB, BCL2, SKP2, PIK3CA, RXRA, PIK3R2, LAMC2, ITGA2, MYC, LAMB3, RB1, ITGA6, NOS2, ITGA2B, PIK3CB, TRAF4, LAMA3, LAMA5, AKT2, COL4A1, PTGS2, PTEN, CDKN1B, TRAF3, CCND1, PIAS2, ITGA3, COL4A4, ITGAV, IKBKG, COL4A2, E2F2",0.518557371497695,0.150580586203101,FALSE +"HCC95","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.22491,-0.829,0.653,15588,0.958,"SNAP29, SNAP25, VTI1B, STX1A, BET1L, STX11, STX7, STX2, STX4, STX1B, VAMP5, SEC22B, STX12",0.185086818724926,0.0186344909214556,FALSE +"HCC95","Input","KEGG_SPHINGOLIPID_METABOLISM",0.2859,0.95,0.498,3379,0.837,"SPTLC1, UGT8, GLA, KDSR, PLPP1, ACER3, PLPP2, SMPD4, ASAH2",0.302770657240282,0.07727454200674,FALSE +"HCC95","Input","KEGG_SPLICEOSOME",0.36969,1.22,0.181,4681,0.588,"THOC3, NCBP2, DHX8, PPIL1, WBP11, LSM4, LSM2, TRA2B, SNRPE, NCBP1, HSPA1B, U2SURP, ZMAT2, CHERP, EFTUD2, DHX16, PRPF19, SF3B6, THOC1, SNRPC, SNRPB, ALYREF, EIF4A3, SART1, MAGOHB, DDX46, SRSF2, CDC5L, SNRPG, USP39, CRNKL1, AQR, CTNNBL1, SRSF8, TXNL4A, SNRNP200, PRPF4, DDX42, HNRNPA3, LSM6, PRPF6, PHF5A, HNRNPK, SRSF3, SNRPA, SRSF1, SNRNP40, HNRNPM, SNU13, SNRPD1, SRSF7, BUD31, SNRPF, HSPA2, SLU7",0.742321425130815,0.230622673923862,FALSE +"HCC95","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.17776,-0.649,0.926,14597,0.972,"HK3, GBE1, PYGM, TREH, UGT2B7, GYS1, HK2, PGM2L1, PGM1, AMY2B",0.0333890133180656,0.0123337350737254,FALSE +"HCC95","Input","KEGG_STEROID_BIOSYNTHESIS",0.59816,1.93,0.00134,4575,0.351,"CYP51A1, FDFT1, DHCR7, LIPA, LSS, SQLE, HSD17B7, NSDHL, TM7SF2, DHCR24, SC5D, CEL",2.87289520163519,0.454692883534176,FALSE +"HCC95","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.45133,1.46,0.0881,1244,0.504,"AKR1C2, AKR1C1, SRD5A1, AKR1C3, HSD17B8, CYP1B1, UGT2B17",1.05502409158795,0.297569463554475,FALSE +"HCC95","Input","KEGG_SULFUR_METABOLISM",-0.36818,-1.32,0.115,16790,0.495,"SULT2B1, CHST11, PAPSS2",0.939302159646388,0.305394801066431,FALSE +"HCC95","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.22706,-0.851,0.683,11300,0.961,"CD80, C6, C9, ACTN2, C2, IL10, FCGR2B, FCGR2C, C7, SSB, C3, CTSG, TNF, GRIN2B, FCGR1A, ELANE, FCGR2A, TRIM21, C4A, C8G, C4B",0.165579296318467,0.0172766123314547,FALSE +"HCC95","Input","KEGG_TASTE_TRANSDUCTION",-0.14525,-0.538,0.996,13138,0.996,"TAS2R1, SCNN1G, TAS2R9, TAS2R40, ASIC2, SCNN1B, PDE1A, TAS2R43, PLCB2, TAS1R3, ADCY4, KCNB1, TAS2R10, CACNA1A, GNG13, PRKACB, GNB1, ADCY6",0.00174066157630127,0.00174066157630127,FALSE +"HCC95","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.27527,-1.02,0.37,13917,0.772,"ADO, CDO1, GGT5, CSAD",0.431798275933005,0.112382699664264,FALSE +"HCC95","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.50713,1.65,0.0202,4441,0.435,"HMGCS1, HMGCR, ACAT2, MVK, IDI1",1.69464863055338,0.361510743045363,FALSE +"HCC95","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.18184,-0.664,0.942,16691,1,"RHOA, ZFYVE9, ROCK1, NOG, INHBA, RBX1, ZFYVE16, ACVR2A, TGFB3, CDKN2B, PPP2R1A, ROCK2, THBS3, E2F5",0.0259490972071227,0,FALSE +"HCC95","Input","KEGG_THYROID_CANCER",-0.27302,-0.982,0.447,17381,0.838,"TFG, PAX8, TCF7, PPARG, TCF7L2, TPR",0.349692476868064,0.0767559813697235,FALSE +"HCC95","Input","KEGG_TIGHT_JUNCTION",0.28847,0.956,0.469,4552,0.841,"CLDN8, CLDN11, PPP2R2C, PRKCI, YES1, PPP2CA, EPB41L1, YBX3, JAM3, EXOC4, PRKCH, VAPA, GNAI1, CLDN4, CLDN7, CSNK2A2, MYH14, PRKCQ, CRB3, EXOC3, CLDN1, AMOTL1, F11R, KRAS, MYL12B, TJAP1, HRAS, PATJ, CSNK2A1, LLGL2, TJP1, PPP2R1B, SRC, AKT2, PRKCZ, CLDN16, MYL2, PTEN",0.328827157284917,0.0752040042020878,FALSE +"HCC95","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.20404,0.661,0.92,4347,1,"TRAF6, IKBKB, PIK3CA, IRF5, PIK3R2, MAPK13, MAPK9, SPP1, MAPK10, MAPK12, MAP2K6, IL1B, TLR6, PIK3CB, MAP3K7, FOS, CD40, MAPK1, MAPK8, AKT2, CD86, MAPK14, MAPK11",0.0362121726544447,0,FALSE +"HCC95","Input","KEGG_TRYPTOPHAN_METABOLISM",0.32699,1.09,0.297,1664,0.709,"CAT, EHHADH, CYP1B1, ALDH3A2, AFMID, KYNU",0.527243550682788,0.149353764816933,FALSE +"HCC95","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.3788,1.26,0.17,4419,0.564,"IKBKB, MAFA, PIK3CA, PIK3R2, IRS1, MAPK9, SOCS1, MAPK10, SLC2A4, PIK3CB, CACNA1B, MAPK1, MAPK8, GCK, CACNA1D, HK1, PRKCZ, PKM",0.769551078621726,0.248720896016658,FALSE +"HCC95","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.28898,0.951,0.511,4858,0.844,"IL1A, IL1B, GAD1, CD86, IL12A",0.291579099865287,0.073657553374345,FALSE +"HCC95","Input","KEGG_TYROSINE_METABOLISM",0.48802,1.59,0.0399,2780,0.478,"ADH7, ALDH3A1, BUD23, AOC2, GOT2, METTL2B, AOC3, ADH5, GOT1",1.39902710431325,0.320572103387881,FALSE +"HCC95","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.29421,0.985,0.443,4493,0.807,"DLG1, PAK2, PPP3R2, IKBKB, PTPN6, GRB2, PIK3CA, PIK3R2, MAPK13, PAK6, NCK1, MAPK9, NFATC1, PAK1, MALT1, MAPK12, NFKBIB, LCK, PRKCQ, CBLC, PIK3CB, MAP3K7, CD8A, KRAS, FOS, HRAS, NCK2, MAPK1, PAK4, AKT2, NFATC3, MAPK14, MAPK11, CHP1, VAV2",0.35359627377693,0.0931264652779296,FALSE +"HCC95","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.27263,0.891,0.596,3547,0.862,"TRAF6, UBA2, KLHL13, ANAPC1, FBXW11, FBXO2, UBE3C, UBE2H, HERC2, SKP2, UBE2S, UBE2D2, ANAPC11, UBE2B, PRPF19, TRIM37, BRCA1, SOCS1, CDC23, CUL1, UBE2O, KEAP1, UBE3A, ITCH, CBLC, UBR5, CDC26, RNF7, PML, FBXO4, UBE2Z, FANCL, ERCC8",0.224753740259764,0.0644927341752872,FALSE +"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.44179,-1.61,0.0467,16289,0.507,"LARS2, PDHB, PDHA1",1.33068311943389,0.294992040666664,FALSE +"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.31015,1.01,0.419,3596,0.804,"HMGCS1, EHHADH, AUH, MCCC1, ALDH3A2, PCCB, MCCC2, HADHA, ACAT2, BCAT1, IVD, OXCT1, ALDH2, HADHB, BCAT2",0.377785977033705,0.0947439512515487,FALSE +"HCC95","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.20647,0.673,0.926,2730,1,"CALML3, ADCY3, ADRA1A, GNA13, PLA2G4B, PLCB1, ADORA2B, ADCY1, PRKCH, PRKACA, ITPR3, PLA2G4A, PLA2G12A, KCNMB3, BRAF, PRKCQ",0.0333890133180656,0,FALSE +"HCC95","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.29995,-1.12,0.258,16613,0.607,"PRKACB, RAB11B, RAB5B, STX4, ADCY6, CREB3, CREB3L1, DCTN6, DYNC1I2, DYNC1LI1, RAB5A",0.58838029403677,0.216811308924742,FALSE +"HCC95","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.25659,0.843,0.679,4481,0.901,"RAC3, HSPB1, PPP3R2, BAD, PIK3CA, PIK3R2, PLA2G4B, MAPK13, NFATC1, PLA2G4A, PLA2G12A, MAPK12, PIK3CB, KRAS, HRAS, MAPK1, SRC, AKT2, NFATC3, MAPK14, PTGS2, MAPK11, CHP1",0.168130225719498,0.045275209020937,FALSE +"HCC95","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.25168,-0.931,0.536,17767,0.874,"ACTB, PRKCA, KDELR1, ATP6V0B, SEC61A2, ATP6V1D, ATP6V1A, SEC61A1, ATP6V0D1",0.27083521030723,0.058488567365597,FALSE +"HCC95","Input","KEGG_VIRAL_MYOCARDITIS",0.18653,0.602,0.961,924,1,"EIF4G1, RAC3, CAV1",0.0172766123314547,0,FALSE +"HCC95","Input","KEGG_WNT_SIGNALING_PATHWAY",0.39701,1.32,0.135,2533,0.504,"WNT3A, SENP2, TBL1XR1, FZD1, RAC3, WNT5A, WNT8B, SFRP5, FZD10, DVL3, WNT10A, PPP3R2, WNT7B, NLK, PRICKLE1, PPP2CA, WNT11, FBXW11, WNT10B, PPP2R5D, FZD9, PLCB1, WNT9A, AXIN1, WNT7A, VANGL1, WNT16, MAPK9, PRKACA, MYC, NFATC1, WNT4, MAPK10, CSNK1A1, LEF1, CCND2, CCND3, CSNK2A2, CUL1",0.869666231504994,0.297569463554475,FALSE +"H1975","Input","KEGG_ABC_TRANSPORTERS",0.22788,0.708,0.885,2824,0.95,"ABCA1, ABCB8, ABCG2, ABCB9, ABCB7, ABCA3, ABCA7",0.0530567293021746,0.0222763947111523,FALSE +"H1975","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.27617,0.863,0.667,4088,0.898,"RPS6KB2, MAP2K2, CCNA1, MYC, ARAF, PPARD, PIM2, PIK3R2, CHUK, IKBKG, PIK3CA, RARA, STAT5B, MAPK1, PIK3CB",0.175874166083451,0.0467236633326956,FALSE +"H1975","Input","KEGG_ADHERENS_JUNCTION",0.2968,0.933,0.552,6665,0.851,"SNAI1, RAC2, FER, ACTN1, RAC1, ACTB, INSR, MET, SORBS1, CDH1, PTPN1, WASL, MAPK1, RHOA, SNAI2, VCL, EGFR, IQGAP1, CSNK2A1, SMAD4, EP300, SMAD3, TJP1, PTPN6, PTPRF, ACTG1, PARD3, TGFBR1, TGFBR2, NECTIN4, ERBB2, TCF7, NECTIN1, BAIAP2",0.258060922270801,0.0700704399154121,FALSE +"H1975","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.346,-1.31,0.148,17878,1,"MAPK10, PRKCQ, ADIPOR2, PRKAG1, PPARGC1A, JAK2, AKT3, PCK2, PRKAA2, NFKBIB, ADIPOR1, NFKBIE, PRKAB1, AKT2",0.829738284605043,0,FALSE +"H1975","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.29001,0.912,0.587,3808,0.874,"ASL, GFPT2, GLS, GLUD1, GOT2, ASS1, CPS1, ADSL",0.231361898752386,0.058488567365597,FALSE +"H1975","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.1833,0.571,0.99,4088,0.978,"ATP1A2, INSR, PRKCA, SFN, PIK3R2, FXYD4, IRS1, PIK3CA, MAPK1, PIK3CB",0.00436480540245009,0.00966114521239857,FALSE +"H1975","Input","KEGG_ALLOGRAFT_REJECTION",0.35646,1.11,0.295,2347,0.681,"IL12B, CD40",0.530177984021837,0.166852888087215,FALSE +"H1975","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.22711,-0.832,0.611,12217,0.974,"PLA2G4E, PLA2G12B, PLA2G2F, PLA2G5, PLA2G2A, ACOX3, PLA2G1B, PLA2G3, PLA2G10, PLA2G4A, PLA2G4B",0.213958789757446,0.0114410431213845,FALSE +"H1975","Input","KEGG_ALZHEIMERS_DISEASE",0.28996,0.904,0.593,5115,0.875,"NDUFV1, COX8C, GRIN2A, UQCR11, NDUFS8, CALM1, UQCR10, NDUFA7, ATP5F1B, GRIN1, NDUFB7, COX6B2, BACE1, GRIN2D, NDUFA6, SDHA, FADD, APH1A, NDUFS2, CASP8, NDUFB2, NDUFS7, NDUFA3, SDHC, UQCRC1, ITPR1, ATP5F1D, PSEN1, NDUFB6, NDUFA8, EIF2AK3, CAPN2, HSD17B10, PPP3CA, GSK3B, NAE1, CYCS, MAPK1, COX7B, NDUFA5, APBB1, NDUFV3, ATP2A3, CDK5, NDUFB10, IDE, TNFRSF1A, ITPR3, NDUFA4, PSEN2, NDUFS6, ATF6",0.226945306635737,0.0579919469776868,FALSE +"H1975","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.56287,1.74,0.0199,2635,0.461,"FARS2, FARSA, TARS2, DARS2, LARS2, IARS2, CARS2, EARS2",1.70114692359029,0.336299074610352,FALSE +"H1975","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.43562,1.37,0.101,5221,0.496,"GCK, GFPT2, GNPDA1, GMPPA, CYB5R3, HK2, RENBP, GMPPB, NANP, GALK1, PGM2, AMDHD2, NANS, UAP1, UGDH, HEXB, HK1, NAGK, PMM1, GNPNAT1, UGP2",0.995678626217357,0.304518323509803,FALSE +"H1975","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.28289,0.884,0.631,3910,0.877,"CCS, GRIN2A, GRIN1, TP53, GRIN2D, RAC1, TOMM40L, GPX1, MAPK12, CAT, PPP3CA, CYCS, MAPK13",0.199970640755866,0.0570004066339595,FALSE +"H1975","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.33851,1.07,0.333,5574,0.733,"HSP90AA1, LGMN, CIITA, KLRC1, IFI30, CD74, HSPA1A, CTSL, HSPA2, NFYA, HSPA1B, HSPA8, KIR2DL1, CTSS, CTSB, TAP2, PSME1, CALR, CREB1, RFXANK, RFX5, PSME2, PSME3",0.47755576649368,0.134896025358872,FALSE +"H1975","Input","KEGG_APOPTOSIS",0.24908,0.78,0.79,4699,0.96,"PRKAR1B, IL1RAP, TP53, ENDOD1, AIFM1, FADD, IRAK1, TRADD, CASP8, CASP10, IL1R1, IRAK4, PRKACA, PIK3R2, XIAP, CHUK, IKBKG, PRKAR2A, PIK3CA, CAPN2, PPP3CA, MYD88, CYCS, PIK3CB, RIPK1, DFFA, TNFRSF1A",0.102372908709559,0.0177287669604316,FALSE +"H1975","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.32602,1.03,0.412,2668,0.755,"CYP2C9, CYP2E1, GPX4, CYP2C8, PLA2G2C, PTGES2, PTGES, GPX3, GPX1",0.385102783966865,0.122053048370812,FALSE +"H1975","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.4526,1.41,0.0961,3980,0.465,"NOS3, ASL, ALDH9A1, SAT2, SMS, GLS, OAT, GLUD1, MAOB, ALDH1B1, GOT2, P4HA1, P4HA3, ASS1, SRM, NAGS, CPS1, MAOA",1.01727661233145,0.332547047110046,FALSE +"H1975","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.25699,-0.962,0.455,15938,1,"CACNG7, ITGA7, SGCD, ITGA9, ACTN2, CACNA2D3, CACNA2D4, CACNB4, CACNA1C, RYR2, LAMA2, CACNA1D, ITGA4, ATP2A2, SLC8A1, DMD, LEF1, PKP2, CACNA2D1, ITGB8, CDH2",0.341988603342888,0,FALSE +"H1975","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.31672,0.982,0.473,4264,0.833,"ALDH9A1, ALDH1B1, UGDH",0.325138859262188,0.0793549985932124,FALSE +"H1975","Input","KEGG_ASTHMA",0.51364,1.6,0.0301,16,0.363,"RNASE3",1.52143350440616,0.440093374963888,FALSE +"H1975","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.39029,-1.43,0.0698,10027,1,"IFNA4, TSHR, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, IL2, FASLG, TSHB, CD80, IFNA13, CTLA4, IL10, IFNA21, PRF1, TPO, IFNA8, CGA, IFNA1, IFNA5, CD86, GZMB, FAS, TG, IL5",1.15614457737684,0,FALSE +"H1975","Input","KEGG_AXON_GUIDANCE",0.30621,0.962,0.501,5502,0.835,"SEMA5B, LIMK1, PAK6, NGEF, RAC2, ABLIM3, NTN1, EPHB4, PAK2, SEMA4B, EFNA4, RASA1, RAC1, EFNA1, SEMA7A, PAK1, SEMA3A, SEMA3B, MET, GNAI2, ABLIM1, CFL2, ABLIM2, UNC5A, PLXNB3, PPP3CA, GSK3B, NFATC3, NRP1, EPHA1, MAPK1, SRGAP1, RHOA, EPHB2, SEMA6C, EPHA6, CDK5, ROCK2, ABL1, EFNB2, SEMA3C, SEMA6B, RHOD, SEMA3E, ITGB1, ROBO3, SRGAP2, GNAI1, SEMA4C, EFNA5",0.300162274132754,0.0783135245163979,FALSE +"H1975","Input","KEGG_BASAL_CELL_CARCINOMA",-0.21862,-0.805,0.712,15646,0.982,"WNT2B, FZD5, GLI1, WNT7A, DVL3, WNT8B, FZD7, WNT6, HHIP, WNT10A, AXIN2, WNT4, WNT11, WNT5A, FZD8, FZD1, LEF1, WNT5B, SMO",0.147520006363144,0.00788851221305034,FALSE +"H1975","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.26325,-0.947,0.411,17864,1,"TAF13, GTF2F2, GTF2B, STON1, GTF2A2, GTF2H2",0.386158178123931,0,FALSE +"H1975","Input","KEGG_BASE_EXCISION_REPAIR",0.37222,1.17,0.219,4598,0.597,"POLD4, POLD2, NTHL1, SMUG1, APEX2, APEX1, OGG1, MBD4, PARP2, POLE3, POLE2, PCNA, PARP3, POLE4",0.659555885159882,0.224025668870631,FALSE +"H1975","Input","KEGG_BETA_ALANINE_METABOLISM",0.54922,1.69,0.02,4373,0.298,"AOC2, ALDH9A1, SMS, AOC3, ECHS1, ALDH1B1, HADHA, SRM, EHHADH",1.69897000433602,0.525783735923745,FALSE +"H1975","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.34961,1.09,0.323,4115,0.7,"ELOVL6, HACD1, ACAA1, HADHA, ACOT4, ACOT1, SCD",0.490797477668897,0.154901959985743,FALSE +"H1975","Input","KEGG_BLADDER_CANCER",-0.26046,-0.984,0.456,17226,1,"FGFR3, EGF, E2F2, HRAS, CXCL8, MMP2, MDM2, VEGFC, KRAS, RB1",0.341035157335565,0,FALSE +"H1975","Input","KEGG_BUTANOATE_METABOLISM",0.36894,1.15,0.245,3682,0.624,"ALDH9A1, ECHS1, PDHA1, ACAT1, ALDH1B1, HADHA, L2HGDH, OXCT1, PDHB, ACSM3",0.610833915635468,0.204815410317576,FALSE +"H1975","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.2891,0.903,0.589,4395,0.868,"CD79A, CD19, VAV1, MAP2K2, RAC2, LILRB3, CARD11, RAC1, LYN, PIK3R2, IFITM1, CHUK, IKBKG, PIK3CA, PPP3CA, GSK3B, NFATC3, MAPK1, PIK3CB, VAV2, PLCG2",0.229884705212898,0.0614802748235081,FALSE +"H1975","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.27157,0.85,0.68,2913,0.891,"NOS3, P2RX6, GRIN2A, MYLK2, PTGER1, P2RX5, GNA15, CALM1, GRIN1, CACNA1B, CACNA1A, ADCY7, GNA11, PHKA1, ADORA2B, EDNRA, ADORA2A, HRH1, MYLK, GRIN2D, TBXA2R, SPHK1, PRKCA, F2R, TRPC1, ITPR1, PRKACA, SLC25A5, ATP2B1, ATP2B4",0.167491087293764,0.0501222959631252,FALSE +"H1975","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.24677,-0.904,0.587,16714,1,"CACNA2D3, CACNA2D4, ATP1B1, CACNB4, UQCRFS1, CACNA1C, RYR2, CACNA1D, SLC9A1, TPM2, UQCRHL, ATP2A2, TNNC1, SLC8A1, COX7A2, ATP1A3, CYC1, COX6A1, CACNA2D1, COX6B1",0.231361898752386,0,FALSE +"H1975","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.19139,-0.719,0.879,16314,0.968,"NRXN2, CD6, ITGA9, NLGN4X, SDC2, CNTN1, CD4, ESAM, JAM2, CNTNAP2, CDH4, ITGAM, NRXN3, NCAM2, NEGR1, MPZL1, NLGN1, NCAM1, ITGA4, NFASC, NECTIN2, NRCAM, JAM3, CLDN1, ITGB8, CDH2",0.0560111249262281,0.0141246426916063,FALSE +"H1975","Input","KEGG_CELL_CYCLE",0.37701,1.18,0.23,5773,0.606,"SMC1B, YWHAH, CCNA1, ATR, DBF4, MYC, CDC25B, FZR1, CDK7, TP53, CCNB1, CUL1, PLK1, YWHAQ, CDKN1C, RBL1, BUB3, GADD45B, SFN, CDC20, ESPL1, SMC1A, MCM7, TFDP2, STAG2, BUB1, YWHAE, CCNH, TGFB2, CHEK1, GSK3B, ORC5, CDC45, PCNA, MCM2, E2F4, CDKN2B, TGFB3, MCM6, CDC27, ORC2, ABL1, CDC25C, SMAD4, PKMYT1, ANAPC2, MCM5, SMC3, CHEK2, EP300, ORC6, SMAD3, CDK4, ANAPC1, CDKN2A, SKP1, TTK, E2F1, CDC6, YWHAG",0.638272163982407,0.217527375833714,FALSE +"H1975","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.20737,-0.746,0.8,16907,0.998,"ADCY5, GNG5, XCL1, NFKBIA, CXCL1, SHC2, CSK, CXCL3, ELMO1, GNG2, CXCR4, PIK3CD, HRAS, CXCL8, PRKACB, CCL20, JAK2, ADCY1, PTK2, GNB1, AKT3, PLCB4, PIK3R1, KRAS, ADCY6, GNG4, NFKBIB, PLCB1, CXCL16, AKT2, GSK3A",0.0969100130080564,0.000869458712628891,FALSE +"H1975","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.20631,0.645,0.938,5841,0.977,"MAP2K2, MYC, ARAF, TP53, MECOM, CRK, SHC3, PIK3R2, CHUK, IKBKG, TGFB2, PIK3CA, BCR, STAT5B, MAPK1, CTBP2, PIK3CB, TGFB3, RUNX1, ABL1, SMAD4, BRAF, CBLC, SMAD3, AKT1, CDK4, CDKN2A, E2F1, TGFBR1",0.0277971616209356,0.0101054362812269,FALSE +"H1975","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.43941,-1.57,0.0483,16670,1,"PER2, CRY2, CSNK1D, CRY1",1.31605286924849,0,FALSE +"H1975","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.47633,1.49,0.046,3635,0.424,"PC, IDH3G, IDH3B, MDH2, DLD, PDHA1, SDHA, SDHC, OGDH, CS, PDHB, ACO2",1.33724216831843,0.372634143407267,FALSE +"H1975","Input","KEGG_COLORECTAL_CANCER",0.24649,0.769,0.809,5841,0.962,"RAC2, MYC, ARAF, TP53, RAC1, MLH1, PIK3R2, MSH6, APPL1, APC, TGFB2, PIK3CA, GSK3B, CYCS, MAPK1, RHOA, PIK3CB, TGFB3, SMAD4, RALGDS, BRAF, SMAD3, AKT1, AXIN1, FOS, TGFBR1",0.0920514783877277,0.0168249279621871,FALSE +"H1975","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.33882,1.06,0.35,2604,0.738,"C4B, C4A, SERPINA5, PROS1, SERPINA1, CFB, F8, C3, SERPINE1, PLAU, F2R, TFPI",0.455931955649724,0.131943638176958,FALSE +"H1975","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.41449,1.3,0.134,3574,0.474,"LDHC, LDHA, SMS, DNMT1, ADI1, AHCY, LDHAL6B, GOT2, MTR, SRM",0.872895201635192,0.324221658325915,FALSE +"H1975","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.20255,0.639,0.948,3472,0.975,"CRLF2, CSF1R, IL12B, EPOR, TNFRSF18, TNFRSF11A, CLCF1, TNFRSF6B, TNFSF9, AMH, IL7R, BMP2, IL11, IL13RA1, IL1RAP, CCL26, IL24, TNFSF12, CD70, OSMR, IL4R, IL15RA, CD40, IL1R1, CX3CL1, CCL28, MET, ACVR1B, IL6R, LIFR, CSF1, KITLG, CTF1, CCR4, TGFB2",0.0231916626619338,0.0109953843014632,FALSE +"H1975","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.27408,0.859,0.668,3898,0.889,"AIM2, MAVS, ADAR, POLR3H, POLR3G, POLR3A, DDX58, POLR3GL, CHUK, IKBKG, POLR1C",0.175223537524454,0.0510982390297863,FALSE +"H1975","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.22818,-0.839,0.69,14422,0.986,"IGF1, CACNG1, ADRB1, ACTC1, ADCY2, ITGA1, TGFB1, TNNT2, SGCG, CACNA2D2, ADCY4, TNF, CACNG7, ITGA7, SGCD, ITGA9, CACNA2D3, ADCY5, CACNA2D4, CACNB4, CACNA1C, RYR2, LAMA2, CACNA1D, TPM2, ITGA4, ATP2A2, PRKACB, TNNC1, SLC8A1, ADCY1, DMD, CACNA2D1, ADCY6, ITGB8",0.161150909262745,0.0061230850587888,FALSE +"H1975","Input","KEGG_DNA_REPLICATION",0.48318,1.52,0.0563,5008,0.469,"POLD4, POLD2, RPA3, RNASEH2A, RNASEH1, PRIM1, SSBP1, RFC2, MCM7, POLE3, RNASEH2C, POLE2, RPA1, PCNA, MCM2, MCM6, POLE4, MCM5",1.24949160514865,0.328827157284917,FALSE +"H1975","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.19145,-0.718,0.868,12053,0.946,"SOS2, MAP2K1, ETV6, NOTCH4, PIWIL4, PIWIL3, PIWIL2, PIWIL1, ETV7, NOTCH3, CPEB1, FMN2, KRAS",0.0614802748235081,0.0241088635982073,FALSE +"H1975","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.40864,1.29,0.14,4256,0.483,"CYP2C9, GSTT2, CYP2E1, ALDH3B1, CYP2C8, GSTZ1, GSTO2, ALDH3B2, GSTK1, MAOB, AOX1, MGST1, MGST3, MAOA, FMO4, GSTP1",0.853871964321762,0.316052869248488,FALSE +"H1975","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.42535,1.33,0.12,3217,0.519,"IMPDH2, CDA, HPRT1, UPP1, IMPDH1, UMPS, TYMP, UCK2, ITPA, TK2",0.920818753952375,0.284832642151542,FALSE +"H1975","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.20917,-0.791,0.74,15893,0.987,"CD36, ITGA7, COL11A1, COL5A3, THBS2, HSPG2, ITGA9, SDC2, VWF, LAMA5, COL4A4, COL3A1, LAMA2, LAMC3, LAMA1, SV2A, COL5A2, ITGA4, LAMA4, ITGB8, COL4A1, COL4A2, LAMB1",0.130768280269024,0.00568284733036327,FALSE +"H1975","Input","KEGG_ENDOCYTOSIS",0.24636,0.762,0.811,5364,0.966,"CSF1R, CHMP2A, RABEP1, EPN1, SMURF1, CHMP3, SH3KBP1, RAB31, LDLR, DNM2, GRK5, PIP5K1C, RAB11B, GRK3, HSPA1A, PLD2, F2R, RBSN, HSPA2, MET, STAM, SH3GL1, AP2M1, EHD2, GRK2, IQSEC1, PDCD6IP, ITCH, AGAP1, HSPA1B, CHMP4C, AP2B1, HSPA8, EPN3, MVB12A, ARF6, ARFGAP3, PSD4, CLTCL1, VPS45, ACAP1, ARRB1, CLTC, RNF41, EGFR, EEA1, ADRB2, STAM2, CHMP2B, CBLC, RAB11FIP2, SNF8, RAB11FIP1, ARFGAP1",0.090979145788844,0.0150228735845067,FALSE +"H1975","Input","KEGG_ENDOMETRIAL_CANCER",0.24916,0.778,0.782,4970,0.955,"MAP2K2, MYC, ARAF, PTEN, TP53, MLH1, ELK1, PIK3R2, APC, CDH1, PIK3CA, GSK3B, FOXO3, MAPK1, PIK3CB, EGFR, PDPK1, BRAF",0.106793246940152,0.0199966284162537,FALSE +"H1975","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.23816,0.74,0.833,4626,0.984,"ATP6V0D2, NOD1, ATP6V0D1, RAC1, MAP2K4, LYN, PAK1, ATP6V1D, MET, ATP6V1F, ATP6V1E2, MAPK12, CHUK, IKBKG, MAPK13, TCIRG1, F11R, ATP6V0E2, PLCG2, EGFR",0.0793549985932124,0.00700490156865849,FALSE +"H1975","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.24386,0.755,0.814,5113,0.969,"RPS6KB2, MAP2K2, PAK6, MYC, ARAF, PAK2, MAP2K4, CRK, ABL2, PRKCA, ELK1, PAK1, SHC3, MAP2K7, PIK3R2, PIK3CA, GSK3B, STAT5B, MAPK1, PIK3CB, NRG1, PLCG2, EGFR, ABL1, BRAF, CBLC, CAMK2D",0.0893755951107988,0.0136762229492347,FALSE +"H1975","Input","KEGG_ETHER_LIPID_METABOLISM",0.29926,0.94,0.52,4032,0.842,"LPCAT1, PLA2G2C, PAFAH1B1, PLPP2, PLD2, AGPS, PLA2G12A, LPCAT2",0.283996656365201,0.0746879085003505,FALSE +"H1975","Input","KEGG_FATTY_ACID_METABOLISM",0.41741,1.3,0.132,4656,0.474,"GCDH, ALDH9A1, ACSL4, ACAA1, ECHS1, ACSL5, ACAT1, ALDH1B1, HADHA, ACADVL, CPT1C, ACADSB, EHHADH, ACAA2",0.87942606879415,0.324221658325915,FALSE +"H1975","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.2102,-0.763,0.801,16759,1,"MAPK11, INPP5D, PLA2G10, IL13, PLCG1, PLA2G4A, MAPK10, PIK3CD, HRAS, PLA2G4B, AKT3, PIK3R1, GAB2, KRAS, MAP2K6, AKT2",0.0963674839157623,0,FALSE +"H1975","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.27975,0.872,0.628,4395,0.887,"RPS6KB2, VAV1, LIMK1, RAC2, PLA2G4D, ARPC1A, DNM2, PIP5K1C, RAC1, CRK, LYN, ARPC1B, MYO10, SPHK1, PRKCA, PAK1, PLPP2, PLD2, PIK3R2, CFL2, PIK3CA, WASL, ARF6, MAPK1, PRKCD, PIK3CB, VAV2, PLCG2",0.202040356262804,0.0520763801682736,FALSE +"H1975","Input","KEGG_FOCAL_ADHESION",0.22691,0.711,0.874,5199,0.954,"PPP1CA, VAV1, MYLK2, THBS3, PAK6, RAC2, COL5A1, PTEN, ARHGAP5, ITGA5, ITGA2B, PAK2, LAMB3, PIP5K1C, ITGB3, ACTN1, TNC, MYLK, RAC1, ACTB, CRK, CAV2, PRKCA, FLNA, ELK1, ZYX, PAK1, SHC3, CAV1, DIAPH1, MYL9, MET, VTN, MYL7, PIK3R2, XIAP, LAMA3, PIK3CA, COL1A1, PPP1CB, CAPN2, GSK3B, MAPK1, BCAR1, ITGA3, RHOA, PIK3CB, FN1, VAV2, COL1A2, VCL, EGFR, ROCK2, LAMB2, PDPK1, FLNB, ITGA2, LAMC2, BRAF, DOCK1, LAMC1, ITGB1",0.058488567365597,0.0204516252959049,FALSE +"H1975","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.3703,-1.34,0.142,12122,1,"ALPI, ALPL, ALPG, QDPR, ALPP, PTS, GGH, GCH1",0.847711655616944,0,FALSE +"H1975","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.44997,1.39,0.0985,7631,0.472,"ALDOA, FBP1, PFKFB4, ALDOC, GMPPA, AKR1B1, HK2, GMPPB, PFKP, HK1, PFKFB3, PMM1, SORD, MTMR2, PFKFB1, MPI, PFKFB2, PFKL, PFKM, PMM2, FBP2, GMDS, MTMR1",1.00656376950239,0.326058001365912,FALSE +"H1975","Input","KEGG_GALACTOSE_METABOLISM",0.4783,1.5,0.038,6884,0.451,"GCK, AKR1B1, HK2, GALK1, PGM2, PFKP, GLA, HK1, UGP2, GAA, PGM1, B4GALT1, GALE, PFKL",1.42021640338319,0.345823458122039,FALSE +"H1975","Input","KEGG_GAP_JUNCTION",-0.22836,-0.842,0.636,15831,1,"TUBB4A, GNAI3, DRD2, GUCY1B1, HTR2C, PDGFD, ADCY5, PDGFRA, GUCY1A2, PRKG1, PRKG2, GUCY1A1, TUBB1, EGF, CSNK1D, HRAS, PRKACB, MAP2K5, ADCY1, PLCB4, KRAS, ADCY6, LPAR1, PLCB1",0.196542884351586,0,FALSE +"H1975","Input","KEGG_GLIOMA",-0.26745,-1,0.446,17036,1,"PDGFRA, CALML6, CAMK2B, SHC2, EGF, PLCG1, E2F2, PIK3CD, HRAS, AKT3, PIK3R1, MDM2, KRAS, RB1, AKT2",0.350665141287858,0,FALSE +"H1975","Input","KEGG_GLUTATHIONE_METABOLISM",0.41165,1.3,0.126,4822,0.474,"GSTT2, GPX4, ANPEP, GSTZ1, GSTO2, SMS, GSTK1, GPX3, GPX1, RRM2, MGST1, SRM, MGST3, GSTP1, G6PD, GGCT, ODC1, GGT7, GSTM2, GSS",0.899629454882437,0.324221658325915,FALSE +"H1975","Input","KEGG_GLYCEROLIPID_METABOLISM",0.40366,1.27,0.139,4681,0.49,"GPAT2, DGKI, LIPG, AWAT2, ALDH9A1, DGKD, AKR1B1, AGK, DGKG, ALDH1B1, PLPP2, GPAT3, MGLL, MBOAT2, GK, AGPAT4, GLA, DGKE, GPAM",0.856985199745905,0.309803919971486,FALSE +"H1975","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33238,1.04,0.389,4681,0.77,"GPAT2, DGKI, LPCAT1, PLA2G2C, MBOAT7, CDS2, PEMT, CRLS1, DGKD, DGKG, CHKA, PLPP2, PLD2, GPAT3, CHAT, PISD, CDIPT, MBOAT2, PLA2G12A, LPCAT2, AGPAT4, PCYT1A, DGKE, GPAM",0.410050398674292,0.113509274827518,FALSE +"H1975","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.47415,1.47,0.0645,3268,0.442,"SARDH, AOC2, SRR, AOC3, DLD, SHMT1, MAOB, GCAT, PSPH, SHMT2",1.19044028536473,0.354577730650908,FALSE +"H1975","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.50151,1.57,0.0294,2784,0.393,"GCK, LDHC, ALDH3B1, ALDOA, PGK1, LDHA, FBP1, ALDH9A1, ALDH3B2, ALDOC, DLD, PDHA1, GALM, PGAM1, LDHAL6B, ALDH1B1, HK2",1.53165266958784,0.405607449624573,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.36869,1.17,0.227,5040,0.597,"CHST15, CHPF2, CHPF, CHST3, DSE, CHST11, CHST12, UST",0.643974142806877,0.224025668870631,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.19621,-0.729,0.752,12537,0.975,"HS3ST1, HS2ST1, NDST4, HS3ST2, HS6ST1, NDST2, EXTL1, HS3ST5, HS6ST3, NDST3, B3GAT1, B3GAT2, XYLT1",0.123782159408358,0.0109953843014632,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.48123,1.49,0.0596,1059,0.424,"CHST4, CHST6, FUT8, B3GNT7",1.22475374025976,0.372634143407267,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.41649,1.28,0.131,4328,0.48,"IDS, HYAL2, HYAL3, GALNS, HS3ST3B1, HYAL1, NAGLU, HEXB",0.882728704344236,0.318758762624413,FALSE +"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.24119,-0.911,0.531,14944,1,"B3GALT4, ST8SIA5, ST6GALNAC5, ST6GALNAC3, HEXA, ST3GAL5",0.274905478918531,0,FALSE +"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.43308,1.36,0.115,6501,0.502,"FUT2, B3GALNT1, ST3GAL2, GLA, HEXB, A4GALT, NAGA, ST8SIA1, GBGT1, B3GALT5",0.939302159646388,0.299296282854981,FALSE +"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.23892,-0.88,0.62,15377,1,"ST3GAL4, ST3GAL3, B3GALT2, FUT9, B3GALT1, B3GNT2, B4GAT1, B4GALT4, ST3GAL6",0.207608310501746,0,FALSE +"H1975","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.27147,0.829,0.702,6205,0.925,"PIGQ, PIGL, PIGW, DPM2, PIGX, PIGH, PIGA, PIGG, PIGM, PIGB, PIGV, PIGN, PGAP1",0.153662887870195,0.0338582672609674,FALSE +"H1975","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.35487,1.09,0.316,4253,0.7,"MTHFD1, MDH2, CS, ACO2, HYI",0.500312917381596,0.154901959985743,FALSE +"H1975","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.22997,-0.851,0.636,16759,1,"MAPK11, ADCY5, PLA2G10, CACNA1C, CALML6, CAMK2B, CACNA1D, PLA2G4A, MAPK10, HRAS, PRKACB, PLA2G4B, MMP2, GNRH1, ADCY1, PLCB4, KRAS, ADCY6, ATF4, PLCB1, MAP2K6",0.196542884351586,0,FALSE +"H1975","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.26642,-1,0.396,14812,1,"KLRD1, CD86, GZMB, FAS, TNF, IL1A, IL1B",0.402304814074488,0,FALSE +"H1975","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.23504,-0.84,0.606,17337,1,"HHIP, WNT10A, WNT4, WNT11, GAS1, CSNK1D, WNT5A, BMP6, BMP7, PRKACB, WNT5B, SMO",0.217527375833714,0,FALSE +"H1975","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.31328,0.97,0.489,3553,0.844,"CSF1R, CD19, EPOR, ANPEP, IL7R, IL11, ITGA5, ITGA2B, ITGB3, IL4R, IL1R1, IL6R, CSF1, KITLG, CD44",0.31069114087638,0.073657553374345,FALSE +"H1975","Input","KEGG_HISTIDINE_METABOLISM",0.54462,1.71,0.0153,3072,0.387,"FTCD, ALDH3B1, ALDH9A1, ALDH3B2, HEMK1, MAOB, HNMT, METTL6, ALDH1B1, METTL2B",1.8153085691824,0.412289034981089,FALSE +"H1975","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.53981,1.67,0.0306,3919,0.3,"POLD4, POLD2, NBN, RPA3, RAD51B, XRCC2, XRCC3, SSBP1, RAD51D, TOP3B, MRE11, TOP3A, RPA1",1.51427857351842,0.522878745280338,FALSE +"H1975","Input","KEGG_HUNTINGTONS_DISEASE",0.37717,1.16,0.261,3032,0.611,"DNAH2, NDUFV1, CREB3L3, COX8C, DNAH3, UQCR11, NDUFS8, CREB3L1, UQCR10, HIP1, TBPL2, NDUFA7, ATP5F1B, GRIN1, NDUFB7, COX6B2, TP53, RCOR1, POLR2E, DNAH1, PPARG, DNAL1, POLR2J, IFT57, NDUFA6, SDHA, POLR2F, NDUFS2, CASP8, NDUFB2, NDUFS7, TGM2, NDUFA3, SDHC, UQCRC1, GPX1, ITPR1, ATP5F1D, SLC25A5, NDUFB6, AP2M1, NDUFA8, TFAM, POLR2H",0.583359492661719,0.213958789757446,FALSE +"H1975","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.22257,-0.839,0.634,15780,0.986,"TNF, CACNG7, ITGA7, SGCD, ITGA9, CACNA2D3, CACNA2D4, CACNB4, CACNA1C, RYR2, LAMA2, CACNA1D, TPM2, ITGA4, ATP2A2, PRKAG1, TNNC1, SLC8A1, DMD, CACNA2D1, ITGB8, PRKAA2, PRKAB1",0.197910742118267,0.0061230850587888,FALSE +"H1975","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.23056,0.718,0.853,5131,0.967,"PTEN, PIP5K1C, IMPA2, IPMK, PIP4K2C, INPP5J, PIP4K2A, PI4KB, PIK3CA, CDIPT, INPP5K, PIK3C2A, PIK3CB, PLCG2, PIK3C3, PLCE1, SYNJ2",0.069050968832477,0.0145735259169983,FALSE +"H1975","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.3059,0.968,0.496,4088,0.839,"GCK, PPP1CA, RPS6KB2, MAP2K2, PRKAR1B, CALM1, FBP1, ARAF, PYGL, PHKA1, CRK, INSR, ELK1, PRKAG2, SHC3, PPP1R3B, PRKAB2, PRKAA1, HK2, PPP1R3C, PRKACA, TRIP10, PIK3R2, SORBS1, PYGB, IRS1, PRKAR2A, MKNK2, PIK3CA, PHKB, PPP1CB, GSK3B, TSC1, PTPN1, INPP5K, MAPK1, RHEB, PIK3CB",0.304518323509803,0.0762380391712997,FALSE +"H1975","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.20136,-0.737,0.82,14917,0.986,"TGFB1, CD86, ICOSLG, CCL27, IL5, CXCL12, TNFSF13B, TNFRSF13C, CXCR4, ITGA4",0.0861861476162833,0.0061230850587888,FALSE +"H1975","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.21942,0.678,0.908,4091,0.969,"CRLF2, IL12B, EPOR, TYK2, CLCF1, IL7R, MYC, IL11, IL13RA1, IL24, OSMR, IL4R, IL15RA, PIAS4, STAM, PIAS2, PIAS3, PIK3R2, IL6R, LIFR, JAK3, STAT6, CTF1, PIK3CA, STAT5B, IRF9, PIK3CB, IFNGR1",0.0419141514789149,0.0136762229492347,FALSE +"H1975","Input","KEGG_LEISHMANIA_INFECTION",0.22892,0.707,0.874,4133,0.944,"IL12B, C3, IRAK1, ELK1, ITGB2, IRAK4, MAPK12, TGFB2, TAB1, CYBA, MYD88, MAPK1, MAPK13, IFNGR1, TGFB3",0.058488567365597,0.025028005701931,FALSE +"H1975","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.19732,0.615,0.958,5361,0.978,"VAV1, RAC2, ARHGAP5, CLDN9, ACTN1, RAC1, ACTB, CLDN4, PRKCA, ITGB2, MYL9, MSN, MYL7, GNAI2, PIK3R2, ICAM1, MAPK12, CLDN23, CLDN7, PIK3CA, CYBA, MAPK13, BCAR1, RHOA, PIK3CB, F11R, VAV2, PLCG2, SIPA1, VCL, ROCK2, PTK2B, CLDN15, ITGB1, GNAI1, NCF2, CLDN22",0.0186344909214556,0.00966114521239857,FALSE +"H1975","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.6488,2.02,0.00348,4373,0.451,"ALDH9A1, NAA80, ECHS1, ALDH1B1, HADHA, EHHADH",2.45842075605342,0.345823458122039,FALSE +"H1975","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.46749,1.45,0.072,606,0.461,"CYP2C9, CYP2E1, CYP2C8, PLA2G2C",1.14266750356873,0.336299074610352,FALSE +"H1975","Input","KEGG_LONG_TERM_DEPRESSION",0.23549,0.723,0.86,2875,0.976,"PPP2R1A, MAP2K2, PLA2G2C, GNA12, ARAF, CACNA1A, GNA11, LYN, PRKCA, ITPR1, GNAI2",0.0655015487564323,0.0105501823333082,FALSE +"H1975","Input","KEGG_LONG_TERM_POTENTIATION",0.25539,0.782,0.783,2802,0.973,"PPP1CA, GRIN2A, MAP2K2, CALM1, RPS6KA3, GRIN1, ARAF, GRIN2D, RPS6KA2, PRKCA, ITPR1, PRKACA",0.106238237942057,0.0118871597316481,FALSE +"H1975","Input","KEGG_LYSINE_DEGRADATION",0.29949,0.945,0.519,5620,0.839,"GCDH, ALDH9A1, AADAT, SUV39H1, ECHS1, ACAT1, PLOD2, SETMAR, ALDH1B1, HADHA, OGDH, KMT5C, EHHADH, KMT5B, SETD2, PLOD1, ASH1L, PLOD3, DLST",0.284832642151542,0.0762380391712997,FALSE +"H1975","Input","KEGG_LYSOSOME",0.42113,1.32,0.115,4887,0.511,"AP3S1, ACP5, NPC1, ATP6V0D2, LIPA, NAGPA, AP1B1, CTNS, LGMN, GALC, ATP6V0D1, CTSA, ABCB9, AP1S1, IDS, CD68, DNASE2, AP3D1, PSAP, CTSG, SUMF1, CTSF, LAMP2, CTSD, TPP1, GALNS, CTSL, AP1M1, AP1S3, GBA, AP3B1, NPC2, AP4S1, NAPSA, HYAL1, MAN2B1, NAGLU, AGA, CTSS, CLTCL1, GLA, TCIRG1, CTSC, HEXB, CTSB, CLTC, AP1G1, NAGA, NEU1, CTSV, MCOLN1",0.939302159646388,0.291579099865287,FALSE +"H1975","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.22854,0.712,0.89,4176,0.96,"ECSIT, MAP2K2, CACNG8, PLA2G2C, RAC2, MAPKAPK3, MAX, MYC, RPS6KA3, CDC25B, GNA12, CACNA1B, DUSP9, PPM1A, CACNA1A, PAK2, TP53, MECOM, RASA1, HSPB1, RAC1, MAP2K4, CRK, HSPA1A, MAP3K20, RPS6KA2, PRKCA, FLNA, ELK1, PAK1, IL1R1, GADD45B, MAP3K3, MAP2K7, HSPA2, PRKACA, RRAS2, DUSP10, MAP4K4, FGF1, MAPK12, MRAS, CHUK, MAPK8IP2, DUSP2, IKBKG, TGFB2, MKNK2, HSPA1B, HSPA8, PPP3CA, RPS6KA4, TAB1, FGF13, MAPK1, MAPK13, PLA2G12A, DUSP3, TGFB3, MAP3K6",0.0506099933550872,0.0177287669604316,FALSE +"H1975","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.38632,1.21,0.193,11,0.591,"GCK",0.714442690992226,0.228412519118745,FALSE +"H1975","Input","KEGG_MELANOGENESIS",-0.18683,-0.709,0.882,15583,0.936,"NRAS, WNT2B, EDNRB, FZD5, GNAI3, WNT7A, TYRP1, DVL3, WNT8B, FZD7, KIT, ADCY5, WNT6, CALML6, CAMK2B, WNT10A, WNT4, WNT11, WNT5A, HRAS, PRKACB, FZD8, FZD1, ADCY1, LEF1, PLCB4, WNT5B, KRAS, ADCY6, PLCB1",0.0545314148681803,0.0287241512618947,FALSE +"H1975","Input","KEGG_MELANOMA",-0.27622,-1.03,0.375,14247,1,"PIK3R3, FGF19, FGF20, IGF1, CDKN1A, HGF, PIK3CG, FGF18, FGF9, FGF7, FGF21, NRAS, FGF14, CDK6, E2F3, PDGFD, PDGFRA, FGF17, FGF5, EGF, E2F2, PIK3CD, HRAS, FGF12, AKT3, PIK3R1, MDM2, KRAS, FGF2, RB1, AKT2",0.425968732272281,0,FALSE +"H1975","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.41512,1.3,0.13,1829,0.474,"CYP2C9, GSTT2, CYP2E1, ALDH3B1, CYP1B1, CYP2C8, GSTZ1, GSTO2, ALDH3B2, GSTK1",0.886056647693163,0.324221658325915,FALSE +"H1975","Input","KEGG_MISMATCH_REPAIR",0.5466,1.7,0.0187,4075,0.356,"POLD4, POLD2, RPA3, PMS2, MLH1, SSBP1, RFC2, MSH6, EXO1, RPA1, PCNA",1.7281583934635,0.448550002027125,FALSE +"H1975","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.25271,0.78,0.767,4088,0.96,"RPS6KB2, RPS6KA3, CAB39, HIF1A, MLST8, RPS6KA2, PRKAA1, RICTOR, PIK3R2, PIK3CA, STK11, TSC1, MAPK1, RHEB, PIK3CB",0.115204636051019,0.0177287669604316,FALSE +"H1975","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.21448,0.667,0.918,4488,0.972,"VAV1, MAP2K2, RAC2, ARAF, KLRC1, RAC1, ICAM2, PRKCA, PAK1, ITGB2, SHC3, RAET1E, PIK3R2, ULBP3, RAET1L, ICAM1, PIK3CA, PPP3CA, NFATC3, SH3BP2, MAPK1, KIR2DL1, PIK3CB, IFNGR1, VAV2, PLCG2, RAET1G",0.0371573187987575,0.0123337350737254,FALSE +"H1975","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.19263,0.6,0.977,2791,0.972,"GLP2R, P2RX6, GRIN2A, PTGER1, P2RX5, GIPR, GRIN1, CALCR, GABRD, TRPV1, P2RY6, F2RL1, FPR1, P2RY14, ADORA2B, EDNRA, ADORA2A, HRH1, GRIN2D, GABRB3, GRM6, NR3C1, CTSG, TBXA2R, P2RY2, MCHR1, F2R, LPAR2, TSPO",0.0101054362812269,0.0123337350737254,FALSE +"H1975","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.25301,-0.903,0.563,17113,1,"FRS2, NFKBIA, IRAK3, CALML6, NTF3, TRAF6, CAMK2B, SHC2, CSK, PLCG1, NGFR, MAPK10, BCL2, PIK3CD, HRAS, TP73, MAP2K5, CAMK4, AKT3, PIK3R1, KRAS, ATF4, NFKBIB, NFKBIE, SORT1, AKT2, BEX3",0.249491605148654,0,FALSE +"H1975","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.43901,1.35,0.121,4413,0.507,"NAMPT, NNMT, NT5C2, PNP, NT5M, AOX1, NMRK1, BST1, NT5E, NMNAT1",0.91721462968355,0.294992040666664,FALSE +"H1975","Input","KEGG_NITROGEN_METABOLISM",0.31586,0.981,0.462,2132,0.825,"CA9, GLS, CA12, GLUD1",0.335358024443874,0.0835460514500749,FALSE +"H1975","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.23487,-0.901,0.53,15780,1,"TNF, BIRC2, TNFAIP3, SUGT1, NOD2, TAB2, IKBKB, MAPK11, MAP3K7, IL1B, NFKBIA, TRAF6, NLRP3, CXCL1, NLRC4, MAPK10, CXCL8, BIRC3, HSP90B1, NFKBIB",0.275724130399211,0,FALSE +"H1975","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.34581,1.06,0.351,3926,0.738,"XRCC4, XRCC6, MRE11, NHEJ1",0.454692883534176,0.131943638176958,FALSE +"H1975","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.33082,-1.21,0.209,17577,1,"EGF, PLCG1, E2F2, PIK3CD, HRAS, RARB, FHIT, AKT3, CASP9, PIK3R1, KRAS, RB1, AKT2",0.679853713888946,0,FALSE +"H1975","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.19857,0.617,0.946,6732,0.983,"SNW1, DTX3L, APH1A, DVL2, LFNG, MFNG, PSEN1, NOTCH1, CTBP2, JAG1, PSEN2, DVL1, EP300, NUMB, NOTCH2, RBPJ, DTX3, NCSTN, HES1, KAT2A, MAML1",0.0241088635982073,0.00744648216786438,FALSE +"H1975","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.3761,1.17,0.242,4644,0.597,"ERCC6, POLD4, RAD23A, CETN2, CUL4B, POLD2, RPA3, CDK7, RFC2, POLE3, CCNH, POLE2, RPA1, MNAT1, PCNA, RAD23B, POLE4, ERCC8",0.616184634019569,0.224025668870631,FALSE +"H1975","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.2515,0.782,0.785,5039,0.973,"FUT8, ALG10, MGAT5B, RFT1, MGAT2, MAN1B1, ALG1, ALG10B, DPM2, STT3A, MGAT4B, DAD1, ST6GAL1, ALG2, TUSC3, ALG12",0.105130343254747,0.0118871597316481,FALSE +"H1975","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.23366,-0.897,0.576,9443,1,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, CAMK2A, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, CLCA1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR2AE1, OR5AK2, GUCA1A, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR2A7, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, PDC, OR2T4, OR2T6, OR1L6, OR13C4, ADCY3, OR2T12, OR6V1, CNGA3, OR2B3, OR4A47, OR52B4, CAMK2G, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, OR2A1, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR8B12, OR9A4, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, CALM3, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR1B1, OR2L3, OR8D1, OR51E2, OR11H6, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5B21, OR13A1, OR5M11, OR13G1, OR2L13, OR5K1, OR1M1, OR51B2, OR52D1, OR51I1, OR1J1, OR5P3, OR52N2, OR8S1, OR2AT4, OR9A2, OR51Q1, OR13D1, CALM2, OR8D2, OR2T33, OR1J2, OR2A5, OR52H1, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, CALML5, OR4D1, OR8G1, OR4F15, OR52B6, CALML3, OR2A25, OR2D3, OR1Q1, OR8A1, OR10A6, OR2A2, OR8G5, OR11H4, OR10A4, OR51B4, CLCA2, OR2D2, OR2AG1, OR10A3, OR10A2, OR2A14, OR4F17, OR2W3, OR6A2, OR56B4, OR1L8, OR2L2, PDE1C, CALML6, PRKG1, CAMK2B, GNAL, PRKG2, OR2AG2, PRKACB",0.239577516576788,0,FALSE +"H1975","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.54479,1.69,0.0251,3558,0.298,"FTCD, MTHFD1, SHMT1, SHMT2, MTR",1.60032627851896,0.525783735923745,FALSE +"H1975","Input","KEGG_OOCYTE_MEIOSIS",0.3253,1.02,0.421,5253,0.772,"SMC1B, PPP2R1A, PPP1CA, PPP2R5E, YWHAH, CALM1, RPS6KA3, ADCY7, CCNB1, CUL1, PLK1, YWHAQ, PPP2R5C, RPS6KA2, CDC20, ITPR1, ESPL1, PRKACA, SMC1A, MAPK12, BUB1, YWHAE, PPP1CB, PPP3CA, SPDYA, MAPK1, SLK, AURKA, CDC27, ITPR3, CDC25C, PKMYT1, ANAPC2, SMC3, CAMK2D, BTRC",0.375717904164332,0.112382699664264,FALSE +"H1975","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.29778,0.931,0.553,4918,0.846,"GBA, MAN2B1, AGA, HEXB, NEU1, FUCA2, NEU3",0.257274868695302,0.0726296369609765,FALSE +"H1975","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.34869,1.08,0.336,2987,0.717,"NDUFV1, COX8C, ATP6V0D2, UQCR11, NDUFS8, UQCR10, NDUFA7, ATP5F1B, LHPP, NDUFB7, COX6B2, ATP6V0D1, COX10, NDUFA11, NDUFA6, SDHA, NDUFS2, NDUFB2, NDUFS7, NDUFA3, COX15, SDHC, UQCRC1, ATP6V1D, ATP5F1D, ATP6V1F, NDUFB6, NDUFA8, ATP6V1E2",0.473660722610156,0.1444808443322,FALSE +"H1975","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.55449,1.71,0.0163,3554,0.387,"GALNT15, GALNT9, GCNT1, GALNT6, GALNT10, GALNT12, GALNT18, GALNT2, C1GALT1, GALNT11, C1GALT1C1, B4GALT5, GALNT7, ST3GAL2",1.78781239559604,0.412289034981089,FALSE +"H1975","Input","KEGG_P53_SIGNALING_PATHWAY",-0.23845,-0.913,0.532,16247,1,"MDM4, CDK6, CCNG1, RCHY1, APAF1, GADD45G, SESN3, CCND2, COP1, BID, GADD45A, ZMAT3, PIDD1, SESN2, BBC3, TP73, CASP9, CD82, SESN1, MDM2",0.274088367704952,0,FALSE +"H1975","Input","KEGG_PANCREATIC_CANCER",-0.2403,-0.868,0.543,15778,1,"RAD51, VEGFD, CDC42, RAC3, BRCA2, CDK6, E2F3, IKBKB, EGF, E2F2, MAPK10, PIK3CD, ARHGEF6, AKT3, CASP9, PIK3R1, VEGFC, KRAS, RB1, AKT2",0.265200170411153,0,FALSE +"H1975","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.33383,-1.29,0.127,15433,1,"PPCDC, PPCS, VNN2, VNN1, PANK4, PANK3",0.896196279044043,0,FALSE +"H1975","Input","KEGG_PARKINSONS_DISEASE",0.2865,0.9,0.604,2969,0.867,"NDUFV1, COX8C, UQCR11, NDUFS8, UQCR10, NDUFA7, ATP5F1B, NDUFB7, COX6B2, PINK1, UBA7, NDUFA6, SDHA, NDUFS2, NDUFB2, NDUFS7, NDUFA3, SDHC, UQCRC1, ATP5F1D, SLC25A5, NDUFB6, UBE2L3, NDUFA8",0.218963061378868,0.0619809025237897,FALSE +"H1975","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.38604,1.19,0.212,5708,0.604,"TLR5, TUBB3, ARPC1A, LY96, YWHAQ, ACTB, ARPC1B, TUBA4A, PRKCA, TUBB4B, TUBA1B, CDH1, WASL, TUBA1A, TUBA1C, RHOA, NCL, KRT18, ROCK2, ABL1, TUBB6, ITGB1, ARPC5L, ARPC4, CTTN, ACTG1",0.673664139071249,0.218963061378868,FALSE +"H1975","Input","KEGG_PATHWAYS_IN_CANCER",0.19395,0.609,0.957,5225,0.974,"WNT9A, CSF1R, MAP2K2, FZD9, CCNA1, RAC2, EGLN3, MAX, MYC, BMP2, HSP90AA1, RALB, ARAF, PTEN, ITGA2B, LAMB3, TP53, MECOM, PPARD, DAPK3, FZD2, HIF1A, PPARG, TRAF3, EGLN1, RAC1, MLH1, CRK, FADD, NCOA4, RALA, DVL2, CASP8, PRKCA, PIAS4, MET, PIAS2, PIAS3, PIK3R2, TPM3, WNT7B, XIAP, LAMA3, MSH6, MITF, FGF1, APPL1, KITLG, CHUK, IKBKG, CKS1B, APC, TGFB2, CDH1, PIK3CA, EPAS1, RARA, GSK3B, BCR, STAT5B, RXRA, PTCH1, FGF13, CYCS, MAPK1, CTBP2, ITGA3, RHOA, PIK3CB, CDKN2B, TGFB3, FN1, DAPK1, GSTP1, FZD4, ETS1, PLCG2, BMP4, EGFR, RALBP1, RUNX1, ABL1, LAMB2, FH, SMAD4, ITGA2, RALGDS, LAMC2, BRAF, DVL1, CBLC, LAMC1, GLI3, ITGB1, EP300",0.0190880622231565,0.0114410431213845,FALSE +"H1975","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.39142,1.24,0.163,2379,0.534,"RPEL1, XYLB, AKR1B1, DHDH",0.787812395596042,0.272458742971444,FALSE +"H1975","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.48807,1.5,0.0629,1867,0.451,"ALDOA, PRPS2, FBP1, RBKS, PGLS, RPEL1, ALDOC, PRPS1",1.20134935455473,0.345823458122039,FALSE +"H1975","Input","KEGG_PEROXISOME",0.25755,0.791,0.757,4950,0.974,"ACOX2, HACL1, ACSL4, PEX11G, PMVK, PEX19, DHRS4, ACAA1, PEX26, GSTK1, ACSL5, PEX11B, PXMP4, PAOX, DECR2, SLC25A17, CAT, PEX3, AGPS, AMACR, FAR1, EHHADH, CROT, CRAT, EPHX2, PEX2",0.120904120499927,0.0114410431213845,FALSE +"H1975","Input","KEGG_PHENYLALANINE_METABOLISM",0.58904,1.86,0.0116,2497,0.586,"ALDH3B1, AOC2, NAA80, ALDH3B2, AOC3, MIF, MAOB, GOT2",1.93554201077308,0.232102383981909,FALSE +"H1975","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.2887,0.893,0.605,5637,0.874,"DGKI, CALM1, CDS2, PTEN, PIP5K1C, DGKD, IMPA2, DGKG, PRKCA, PIP4K2C, INPP5J, PIP4K2A, ITPR1, PIK3R2, PI4KB, PIK3CA, CDIPT, INPP5K, PIK3C2A, PIK3CB, PLCG2, DGKE, PIK3C3, ITPR3, PLCE1, SYNJ2, DGKA, DGKZ, PI4KA",0.218244625347531,0.058488567365597,FALSE +"H1975","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.44685,1.4,0.0862,5437,0.468,"HMOX1, COX10, HMOX2, UROS, COX15, EARS2, CPOX, ALAD, HCCS, PPOX, HMBS, BLVRA, FTH1, UROD",1.06449273417529,0.329754146925876,FALSE +"H1975","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.30184,0.956,0.502,4836,0.831,"ACOX2, PLTP, ACSL4, SLC27A5, SLC27A4, ANGPTL4, PPARD, ACAA1, PPARG, ACSL5, FABP5, SORBS1, CPT1C, RXRA, NR1H3, GK, SCD, EHHADH, CYP27A1, PDPK1",0.299296282854981,0.080398976215889,FALSE +"H1975","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45483,1.42,0.0739,995,0.464,"ACOX2, HSD3B7, SLC27A5",1.13135556160517,0.333482019445119,FALSE +"H1975","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.386,1.2,0.207,5218,0.592,"CD79A, CD19, IL7R, CIITA, CD40, JAK3, IKBKG, ADA, TAP2, RFXANK, RFX5, LCK",0.684029654543082,0.22767829327708,FALSE +"H1975","Input","KEGG_PRION_DISEASES",0.23302,0.718,0.851,3888,0.967,"MAP2K2, HSPA1A, ELK1, PRKACA, NOTCH1, PRNP, MAPK1",0.0700704399154121,0.0145735259169983,FALSE +"H1975","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.21291,-0.816,0.691,17438,0.985,"CDC16, CPEB1, MAPK10, PIK3CD, PRKACB, ADCY1, ANAPC7, AKT3, ANAPC13, PDE3B, PIK3R1, ANAPC10, KRAS, ADCY6, AKT2",0.160521952625802,0.00656376950238827,FALSE +"H1975","Input","KEGG_PROPANOATE_METABOLISM",0.41945,1.31,0.125,4878,0.504,"LDHC, LDHA, ALDH9A1, ECHS1, ACAT1, LDHAL6B, ALDH1B1, HADHA, PCCB, EHHADH, ACACA, SUCLG1",0.903089986991944,0.297569463554475,FALSE +"H1975","Input","KEGG_PROSTATE_CANCER",-0.281,-0.992,0.456,16569,1,"E2F3, IKBKB, PDGFD, PDGFRA, NFKBIA, AR, FOXO1, EGF, E2F2, BCL2, PIK3CD, HRAS, FGFR2, AKT3, CASP9, LEF1, PIK3R1, MDM2, KRAS, HSP90B1, ATF4, RB1, AKT2",0.341035157335565,0,FALSE +"H1975","Input","KEGG_PROTEASOME",0.40843,1.26,0.161,5843,0.5,"PSMC1, PSMF1, PSMA3, PSMC2, PSMB9, PSMD11, PSMD4, PSMD2, PSMB6, PSMA2, PSMB4, PSMD7, PSMB8, PSMD6, PSMD12, PSMB7, PSMD1, PSME1, PSMC5, SEM1, PSMB5, PSME2, PSME3, PSME4",0.79317412396815,0.301029995663981,FALSE +"H1975","Input","KEGG_PROTEIN_EXPORT",-0.44499,-1.64,0.0465,15662,1,"SPCS3, SEC62, SEC11A, IMMP1L, SEC63, SRP14, SEC11C, IMMP2L, SPCS2",1.33254704711005,0,FALSE +"H1975","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.23675,-0.92,0.537,14779,1,"ATP1B2, MDH1, ATP1A1, FXYD2, SLC38A3, GLS2, CA2, ATP1B1, ATP1A3, PCK2",0.270025714300444,0,FALSE +"H1975","Input","KEGG_PURINE_METABOLISM",0.32959,1.03,0.378,5239,0.755,"POLD4, IMPDH2, NME5, GUCY2D, PRPS2, HPRT1, PDE4A, POLD2, APRT, IMPDH1, ADCY7, AK4, AK7, POLR2E, PDE2A, NME7, PAPSS2, PFAS, ADK, PRPS1, POLR3H, POLR2J, AK1, NT5C2, PNP, POLR2F, GUK1, POLR3G, PRIM1, NT5M, POLR3A, NME2, PDE5A, ITPA, POLR2H, POLR3GL, POLE3, RRM2, POLE2, ENTPD5, ADSL, ADA, POLR1C, NT5E, NME3, NME6, POLR1E, POLE4, PDE6D, POLR1A, PKM, GMPR2, POLR3C, NPR1, NME1, ENTPD6, ENTPD3",0.422508200162775,0.122053048370812,FALSE +"H1975","Input","KEGG_PYRIMIDINE_METABOLISM",0.41103,1.28,0.135,5239,0.48,"POLD4, CDA, NME5, UPP1, POLD2, POLR2E, NME7, POLR3H, POLR2J, NT5C2, PNP, POLR2F, UMPS, UPRT, CMPK2, POLR3G, TYMP, PRIM1, NT5M, UCK2, POLR3A, NME2, ITPA, POLR2H, DHODH, TK2, POLR3GL, POLE3, RRM2, POLE2, ENTPD5, POLR1C, NT5E, NME3, NME6, POLR1E, POLE4, POLR1A, CAD, POLR3C, DTYMK, NME1, ENTPD6, ENTPD3",0.869666231504994,0.318758762624413,FALSE +"H1975","Input","KEGG_PYRUVATE_METABOLISM",0.51518,1.63,0.0319,3486,0.337,"LDHC, PC, LDHD, LDHA, ALDH9A1, MDH2, DLD, AKR1B1, PDHA1, ACAT1, LDHAL6B, ALDH1B1, ME3, HAGHL, PDHB",1.49620931694282,0.472370099128661,FALSE +"H1975","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.27955,0.879,0.63,5366,0.88,"PPP1CA, VAV1, MAP2K2, MYLK2, LIMK1, PAK6, RAC2, GNA12, ARAF, ITGA5, ITGA2B, PAK2, ARPC1A, PIP5K1C, ITGB3, ACTN1, MYLK, RAC1, ACTB, CRK, ARPC1B, PIP4K2C, PAK1, ENAH, ITGB2, F2R, DIAPH1, TMSB4X, DIAPH2, IQGAP3, MYH9, MYL9, SSH3, MSN, PIP4K2A, ITGAE, RRAS2, MYL7, PIK3R2, FGF1, FGD1, MRAS, SSH2, CFL2, APC, TIAM1, PIK3CA, PPP1CB, WASL, FGF13, MAPK1, BCAR1, ITGA3, RHOA, PIK3CB, FN1, MYH10, VAV2, VCL, EGFR, ROCK2, IQGAP1, ITGA2, BRAF, DOCK1, GNA13, ITGB1, ITGAX, TIAM2, ARPC5L, ARPC4",0.200659450546418,0.0555173278498314,FALSE +"H1975","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.22708,0.712,0.876,5419,0.96,"ATG7, ATG12, ATG4A, PIK3R4, PRKAA1, GABARAP, ATG3, PIK3C3, BECN1, ULK2",0.0574958938319193,0.0177287669604316,FALSE +"H1975","Input","KEGG_RENAL_CELL_CARCINOMA",0.26049,0.817,0.741,4320,0.941,"MAP2K2, PAK6, EGLN3, ARAF, PAK2, HIF1A, FLCN, EGLN1, RAC1, CRK, PAK1, MET, PIK3R2, TGFB2, PIK3CA, EPAS1, MAPK1, PIK3CB, TGFB3, ETS1",0.130181792020672,0.0264103765727431,FALSE +"H1975","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.5803,1.8,0.00946,1975,0.55,"ANPEP, THOP1, AGT, CTSA, NLN, CTSG",2.02410886359821,0.259637310505756,FALSE +"H1975","Input","KEGG_RETINOL_METABOLISM",0.30349,0.951,0.513,2503,0.834,"CYP2C9, CYP2C8, AWAT2, RDH11, DHRS4, CYP26B1, RETSAT, DHRS4L2",0.289882634888184,0.0788339493622613,FALSE +"H1975","Input","KEGG_RIBOFLAVIN_METABOLISM",0.42251,1.32,0.132,2422,0.511,"ACP5, ACP6, FLAD1",0.87942606879415,0.291579099865287,FALSE +"H1975","Input","KEGG_RIBOSOME",-0.18877,-0.688,0.9,16443,0.92,"RPS20, RPLP0, RPL9, RPL11, RPL6, RPS6, RSL24D1, RPL18, RPS27A, RPS8, RPL4, RPS4Y1, RPL21, RPL13A, RPS11, RPS16, RPS19",0.0457574905606751,0.0362121726544447,FALSE +"H1975","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.36806,1.14,0.249,4513,0.638,"IL12B, MAVS, TRIM25, PIN1, ATG12, CYLD, TRAF3, FADD, ISG15, TRADD, CASP8, CASP10, DDX58, DHX58, RNF125, MAPK12, CHUK, IKBKG, MAPK13, TBKBP1, AZI2, DDX3X, NLRX1, RIPK1",0.603800652904264,0.195179321278838,FALSE +"H1975","Input","KEGG_RNA_DEGRADATION",0.31907,0.984,0.463,7135,0.839,"LSM7, CNOT3, PAPOLA, LSM5, EDC4, CNOT4, HSPD1, MPHOSPH6, CNOT10, CNOT7, ENO1, XRN2, EXOSC7, CNOT6, PARN, EXOSC2, EXOSC3, SKIV2L, TTC37, LSM8, ENO2, EXOSC5, PATL1, LSM3, CNOT1, HSPA9, LSM4, EXOSC1, DCP1A, CNOT6L, ZCCHC7, PAPOLB",0.334419008982047,0.0762380391712997,FALSE +"H1975","Input","KEGG_RNA_POLYMERASE",0.33649,1.05,0.371,4966,0.754,"POLR2E, POLR3H, POLR2J, POLR2F, POLR3G, POLR3A, POLR2H, POLR3GL, POLR1C, POLR1E, POLR1A, POLR3C",0.430626090384954,0.122628654130226,FALSE +"H1975","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.31331,0.96,0.495,4567,0.83,"PAPSS2, HEMK1, AHCY, METTL6, METTL2B, SEPHS1, SCLY, GGT7",0.305394801066431,0.0809219076239261,FALSE +"H1975","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.32651,-1.23,0.167,16569,1,"E2F3, IKBKB, APAF1, PTGS2, PIAS1, LAMA5, COL4A4, NFKBIA, TRAF6, LAMA2, LAMC3, LAMA1, E2F2, BCL2, PIK3CD, RARB, FHIT, PTK2, AKT3, LAMA4, CASP9, BIRC3, PIK3R1, COL4A1, RB1, COL4A2, LAMB1, AKT2",0.777283528852417,0,FALSE +"H1975","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.42031,1.31,0.121,4374,0.504,"VTI1B, STX10, USE1, STX8, VTI1A, VAMP7, YKT6, SNAP47, VAMP8, STX4, SNAP29, STX1A, SNAP23, STX3, STX1B",0.91721462968355,0.297569463554475,FALSE +"H1975","Input","KEGG_SPHINGOLIPID_METABOLISM",0.35951,1.13,0.271,7055,0.652,"SPTLC2, GALC, SGPP1, SPHK1, PLPP2, SGMS2, SGMS1, GBA, GLA, SMPD4, UGCG, NEU1, NEU3, KDSR, PLPP3, B4GALT6, ASAH2, SPTLC1, SGPL1, SMPD1, ARSA",0.567030709125594,0.18575240426808,FALSE +"H1975","Input","KEGG_SPLICEOSOME",0.33022,1.03,0.389,5449,0.755,"PRPF31, SNW1, CTNNBL1, LSM7, RBM8A, ISY1, PQBP1, PRPF8, DHX38, HNRNPM, SNU13, HSPA1A, LSM5, PLRG1, U2AF2, SNRPB, RBM25, SRSF6, NCBP1, HSPA2, SF3B3, EFTUD2, CRNKL1, PRPF4, U2SURP, HSPA1B, HSPA8, BUD31, PPIL1, SLU7, DDX46, PRPF19, SNRPB2, SF3B4, SRSF1, SRSF5, SMNDC1, PRPF3, SF3A2, HNRNPK, XAB2, LSM8, PRPF6, SNRPD3",0.410050398674292,0.122053048370812,FALSE +"H1975","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.38786,1.2,0.199,4362,0.592,"GCK, PGM2L1, PYGL, HK2, PYGB, GBE1, PGM2, UGDH, HK1",0.701146923590293,0.22767829327708,FALSE +"H1975","Input","KEGG_STEROID_BIOSYNTHESIS",0.35022,1.09,0.321,1600,0.7,"LIPA, SOAT1, NSDHL",0.493494967595128,0.154901959985743,FALSE +"H1975","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.29429,0.911,0.572,1748,0.867,"CYP11B1, CYP1B1, HSD17B6, STS",0.242603971206976,0.0619809025237897,FALSE +"H1975","Input","KEGG_SULFUR_METABOLISM",0.30808,0.966,0.485,5223,0.835,"SULT1A4, PAPSS2, CHST11, SUOX, CHST12, SULT2B1, BPNT1",0.314258261397736,0.0783135245163979,FALSE +"H1975","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.37457,1.18,0.229,3754,0.606,"GRIN2A, C4B, C4A, C3, ACTN1, CTSG, CD40, SNRPB, TRIM21, C1R",0.640164517660112,0.217527375833714,FALSE +"H1975","Input","KEGG_TASTE_TRANSDUCTION",-0.1951,-0.755,0.79,12258,1,"TAS2R41, TAS2R8, PLCB2, PRKACG, GRM4, TAS1R2, TAS2R20, SCNN1A, ADCY8, TAS2R39, SCNN1G, GNAS, SCNN1B, TAS2R3, TAS2R38, TAS2R1, ASIC2, ADCY4, PDE1A, TAS2R46, TAS2R31, TAS2R10, TAS2R43, PRKACB, GNB1, ADCY6",0.102372908709559,0,FALSE +"H1975","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.28783,-1.09,0.321,13732,1,"BAAT, GGT5, GGT6, CDO1",0.493494967595128,0,FALSE +"H1975","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.31798,0.987,0.459,2018,0.841,"PMVK, ACAT1",0.338187314462739,0.0752040042020878,FALSE +"H1975","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28547,0.888,0.599,6241,0.877,"PPP2R1A, RPS6KB2, THBS3, AMH, SMURF1, NOG, MYC, BMP2, CUL1, RBL1, TGFB2, LTBP1, MAPK1, RHOA, E2F4, CDKN2B, TGFB3, BMPR1B, BMP4, ID4, ROCK2, SMAD4, BMPR2, EP300, SMAD3, SKP1, TGFBR1, ACVR2B, THBS1, BMPR1A, PPP2R1B, TGFBR2, ACVR1",0.222573177610689,0.0570004066339595,FALSE +"H1975","Input","KEGG_THYROID_CANCER",0.35496,1.11,0.286,3888,0.681,"MAP2K2, MYC, TP53, PPARG, NCOA4, TPM3, CDH1, RXRA, MAPK1",0.543633966870957,0.166852888087215,FALSE +"H1975","Input","KEGG_TIGHT_JUNCTION",-0.18358,-0.692,0.909,16463,0.937,"EPB41, SYMPK, ACTN2, VAPA, IGSF5, MAGI2, CSNK2B, PARD6B, HCLS1, JAM2, PPP2CA, PPP2R2B, PRKCQ, EPB41L3, HRAS, PPP2R2C, MYL12B, AMOTL1, JAM3, RAB3B, AKT3, PARD6A, CLDN1, KRAS, MPDZ, AKT2",0.0414361167780325,0.0282604091122217,FALSE +"H1975","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.27278,0.859,0.66,4088,0.889,"IL12B, TLR5, MAP2K2, TICAM2, LY96, TRAF3, RAC1, MAP2K4, FADD, IRAK1, IRF5, CASP8, CD40, MAP2K7, IRAK4, PIK3R2, MAPK12, CHUK, IKBKG, PIK3CA, TAB1, MYD88, MAPK1, MAPK13, TICAM1, PIK3CB",0.180456064458131,0.0510982390297863,FALSE +"H1975","Input","KEGG_TRYPTOPHAN_METABOLISM",0.43105,1.34,0.12,4414,0.513,"GCDH, CYP1B1, ALDH9A1, AADAT, ECHS1, ACAT1, MAOB, ALDH1B1, HADHA, AOX1, OGDH, CAT, MAOA, EHHADH, KYNU",0.920818753952375,0.289882634888184,FALSE +"H1975","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29726,0.915,0.581,4362,0.876,"GCK, CACNA1B, CACNA1A, INSR, HK2, PIK3R2, IRS1, PIK3CA, MAPK1, PRKCD, PIK3CB, HK1",0.235823867609669,0.0574958938319193,FALSE +"H1975","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.23394,0.723,0.846,112,0.976,"IL12B",0.0726296369609765,0.0105501823333082,FALSE +"H1975","Input","KEGG_TYROSINE_METABOLISM",0.44898,1.42,0.0792,3072,0.464,"ALDH3B1, GSTZ1, AOC2, NAA80, ALDH3B2, AOC3, MIF, HEMK1, MAOB, METTL6, GOT2, AOX1, METTL2B",1.10127481841051,0.333482019445119,FALSE +"H1975","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.17955,-0.625,0.923,15555,0.96,"FYN, NRAS, PAK3, TNF, CDC42, IL5, PPP3R1, IKBKB, MAPK11, CD4, MAP3K7, NFKBIA, PLCG1, NCK2, PRKCQ, PIK3CD, HRAS, AKT3, PIK3R1, PAK4, KRAS, NFKBIB, NFKBIE, AKT2",0.0347982989740879,0.0177287669604316,FALSE +"H1975","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.25737,0.809,0.731,6465,0.948,"UBA6, KEAP1, CUL4B, SMURF1, FZR1, PPIL2, HUWE1, STUB1, UBE2D1, UBA7, CUL1, FBXO2, UBE2F, BRCA1, UBE2S, UBE2D4, WWP2, PIAS4, TRIM37, CDC20, UBE2M, HERC4, PIAS2, PIAS3, UBE2L3, XIAP, UBE2C, ITCH, UBE2H, NHLRC1, UBE3C, MID1, PRPF19, UBE2E3, UBE2O, UBA1, UBE2Q1, CDC27, ERCC8, UBE2L6, ANAPC2, CBLC, BTRC, CUL7, CDC34, FBXO4, TRIM32, ANAPC1, UBE2K, SKP1, SIAH1, TRIP12, SOCS3, NEDD4L, MGRN1, BIRC6, UBE4A, UBE2I, CDC26, UBE2G1, CDC23",0.13608262304214,0.0231916626619338,FALSE +"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.56066,1.75,0.0211,3486,0.544,"LARS2, IARS2, PDHA1, PDHB",1.67571754470231,0.26440110030182,FALSE +"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.45051,1.43,0.0725,4656,0.483,"ALDH9A1, HIBADH, ACAA1, DLD, ECHS1, ACAT1, ALDH1B1, HADHA, AOX1, IVD, OXCT1, HSD17B10, PCCB, ACADSB, EHHADH, MCCC2, ACAA2",1.13966199342901,0.316052869248488,FALSE +"H1975","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.23538,0.73,0.874,4060,0.982,"PPP1CA, RAMP1, MAP2K2, MYLK2, PLA2G2C, CALM1, GNA12, ARAF, ADCY7, GNA11, ADORA2B, EDNRA, ADORA2A, MYLK, PRKCA, MYL9, ITPR1, PRKACA, PPP1CB, CALD1, MYL6, MAPK1, PRKCD, PLA2G12A, RHOA",0.058488567365597,0.00788851221305034,FALSE +"H1975","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.3188,1,0.43,6423,0.815,"CREB3L3, CREB3L1, DYNC1H1, RAB11B, DYNC2H1, DYNLL2, PRKACA, CREB5, STX4, DCTN2, CREB3L2, CREB3L4, NSF, CREB1, DYNC1LI1, DYNC1I2, RAB5C, DCTN1, RAB5B, PRKX, ADCY9",0.366531544420413,0.0888423912600234,FALSE +"H1975","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.23242,0.737,0.844,4088,0.98,"NOS3, MAP2K2, PLA2G2C, RAC2, MAPKAPK3, HSPB1, RAC1, SPHK1, PRKCA, PIK3R2, MAPK12, PIK3CA, PPP3CA, NFATC3, MAPK1, MAPK13, PLA2G12A, PIK3CB",0.073657553374345,0.00877392430750515,FALSE +"H1975","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.27487,0.851,0.669,6423,0.897,"ATP6V0D2, ERO1A, ATP6V0D1, TJP2, ACTB, PRKCA, ATP6V1D, PRKACA, ATP6V1F, ATP6V1E2, TCIRG1, ATP6V0E2, PLCG2, KDELR3, SEC61G, ARF1, ATP6V1E1, SEC61A1, TJP1, ATP6V0E1, ACTG1, PDIA4, ATP6V1C1, ATP6V1B2, PRKX, KDELR2, ADCY9",0.174573882232177,0.0472075569559079,FALSE +"H1975","Input","KEGG_VIRAL_MYOCARDITIS",0.32969,1.03,0.413,4251,0.755,"MYH15, RAC2, RAC1, ACTB, ABL2, CASP8, CD40, ITGB2, CAV1, MYH9, EIF4G1, ICAM1, CYCS, DAG1, MYH10",0.384049948343599,0.122053048370812,FALSE +"H1975","Input","KEGG_WNT_SIGNALING_PATHWAY",0.20679,0.653,0.934,4060,0.978,"WNT9A, PPP2R1A, PPP2R5E, PRICKLE2, FZD9, RAC2, MYC, DAAM1, TP53, PPARD, FZD2, CUL1, PRICKLE1, TBL1X, RAC1, PPP2R5C, DVL2, PRKCA, RUVBL1, PRKACA, PSEN1, WNT7B, APC, PPP3CA, GSK3B, NFATC3, CTBP2, FOSL1, DKK1, RHOA",0.0296531237699066,0.00966114521239857,FALSE +"H1648","Input","KEGG_ABC_TRANSPORTERS",0.39832,1.18,0.211,4466,0.672,"ABCC5, ABCA12, ABCC2, ABCB9, ABCA7, ABCA13, ABCC3, ABCB6, ABCD1, TAP2, ABCA1, ABCB11, ABCC1, ABCG1",0.675717544702307,0.172630726946175,FALSE +"H1648","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.38703,1.15,0.24,5702,0.673,"IKBKB, PML, JUP, BRAF, PIK3CB, RUNX1, EIF4EBP1, MAP2K1, RPS6KB2, BAD, NFKB1, PIK3CA, MYC, MTOR, IKBKG, PIM1, STAT5A, CEBPA, RELA, RAF1, STAT5B, TCF7, CCND1, MAP2K2",0.619788758288394,0.171984935776023,FALSE +"H1648","Input","KEGG_ADHERENS_JUNCTION",-0.25687,-0.907,0.567,17254,0.803,"FER, RHOA, CTNNA1, SSX2IP, TCF7L1, PTPRM, FYN, WASF3, NECTIN3, TGFBR1, FGFR1, WASF2, CDC42, SMAD2",0.246416941107093,0.095284454721319,FALSE +"H1648","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.30752,0.924,0.564,5333,1,"NFKBIA, IKBKB, TRADD, NFKBIE, MAPK9, ACSL5, TRAF2, TNFRSF1B, MAPK10, TNF, NFKB1, CAMKK1, STK11, RXRA, MTOR, IKBKG, RELA, IRS1, PRKAB1, CPT1C, CAMKK2, CPT1A, ACSL1",0.248720896016658,0,FALSE +"H1648","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.39667,1.21,0.197,4648,0.645,"IL4I1, NIT2, GLUD1, GAD1, ASL, DDO, ACY3, GLUL, ASS1, CAD, GLS2",0.705533773838407,0.190440285364732,FALSE +"H1648","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.42261,1.26,0.157,5399,0.571,"SCNN1G, SCNN1B, SCNN1A, PIK3CB, SLC9A3R2, SFN, PIK3CA, HSD11B1, HSD11B2, INSR, ATP1B3, IRS1, ATP1A3, ATP1B1",0.804100347590766,0.243363891754152,FALSE +"H1648","Input","KEGG_ALLOGRAFT_REJECTION",0.27671,0.835,0.713,2957,1,"CD40, TNF",0.146910470148134,0,FALSE +"H1648","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.37999,1.14,0.25,5121,0.675,"PLA2G4E, PLA2G4B, PLA2G10, PLA2G12A, PLA2G2F, ACOX1",0.602059991327962,0.170696227168975,FALSE +"H1648","Input","KEGG_ALZHEIMERS_DISEASE",-0.25911,-0.923,0.504,17647,0.788,"UQCRQ, ITPR2, NDUFB3, PLCB4, COX7A2, ATF6, NDUFA8, NDUFA7, NDUFA4, NDUFS4, GNAQ, CALM3, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, APBB1, APAF1, COX6B1, PPP3CB, BACE1, NDUFB2, SDHC, PPP3R1, ATP5MC2, NDUFS5",0.297569463554475,0.103473782510445,FALSE +"H1648","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.33516,-1.17,0.261,16304,0.673,"VARS2, IARS2, NARS2, SARS2, WARS2, PSTK, RARS2, FARS2",0.583359492661719,0.171984935776023,FALSE +"H1648","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.22266,-0.85,0.656,16450,0.863,"PMM2, NANP, GMPPA, NANS, PMM1, CYB5R3, GNPDA2, GFPT1, UGP2, UAP1",0.18309616062434,0.0639892042847904,FALSE +"H1648","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.2113,-0.802,0.807,18004,0.851,"BCL2, ALS2, MAP2K6, MAPK14, APAF1, PPP3CB, PPP3R1",0.0931264652779296,0.0700704399154121,FALSE +"H1648","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.32656,0.984,0.472,5251,0.942,"PSME2, CD74, CTSS, PSME1, CIITA, CANX, IFI30, B2M, TAP2, HSPA1B, HSPA1A, LGMN, TAPBP, PSME3, HSPA4, CTSB, TAP1",0.326058001365912,0.0259490972071227,FALSE +"H1648","Input","KEGG_APOPTOSIS",0.36086,1.1,0.307,4360,0.716,"NFKBIA, IRAK2, BIRC3, IKBKB, IL1A, TRADD, DFFA, CAPN1, PIK3CB, TNFRSF10A, CHP2, TRAF2, IRAK1, MAP3K14, BAD, TNF, MYD88, NFKB1, IL1R1, PRKAR1B, PIK3CA, TNFSF10, TNFRSF10D, TNFRSF10C, CYCS, IKBKG, CFLAR, TNFRSF10B",0.512861624522813,0.145086977692144,FALSE +"H1648","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.54704,1.66,0.021,4164,0.573,"CYP4F3, PLA2G4E, CYP2E1, GPX2, GGT6, CYP2J2, PTGS1, AKR1C3, LTC4S, GGT1, GPX3, PLA2G4B, PLA2G10, CYP2C18, LTA4H, GGT7, PTGES2, ALOX12B, EPHX2, CBR3, CBR1, PLA2G12A",1.67778070526608,0.24184537803261,FALSE +"H1648","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.33383,1,0.461,4888,0.918,"PYCR3, AMD1, CKMT1A, CKMT1B, SAT1, GLUD1, AZIN2, ASL, NOS3, PRODH, GLUL, OAT, MAOA, AOC1, ASS1, GLS2, ALDH3A2, NAGS",0.336299074610352,0.0371573187987575,FALSE +"H1648","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.25143,0.766,0.817,3332,1,"ITGB6, CACNB1, ITGA2, JUP, ITGB4, ITGB8, DSC2, LAMA2, PKP2, CACNA1F, CACNB4, DSP, ITGAV, DSG2",0.0877779434675845,0,FALSE +"H1648","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.32225,-1.14,0.218,18443,0.625,"ALDH1B1, ALDH9A1",0.661543506395395,0.204119982655925,FALSE +"H1648","Input","KEGG_ASTHMA",0.29661,0.902,0.606,2957,1,"CD40, TNF",0.217527375833714,0,FALSE +"H1648","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.24092,0.723,0.88,1371,1,"CD40, TSHB",0.0555173278498314,0,FALSE +"H1648","Input","KEGG_AXON_GUIDANCE",0.26975,0.813,0.748,3063,1,"RND1, PLXNA1, NCK1, MET, SEMA4A, NFATC4, PAK6, SEMA7A, SRGAP3, EPHB3, SEMA4B, EPHA1, PLXNB3, PAK2, RAC2, CHP2, PLXNA2, UNC5A, SEMA3B, EPHA2, PLXNB1, PAK1, ABLIM3, RHOD, EFNA1, LIMK2, PTK2, PLXNB2",0.126098402135539,0,FALSE +"H1648","Input","KEGG_BASAL_CELL_CARCINOMA",0.23492,0.707,0.882,2540,1,"WNT9A, DVL1, DVL3, WNT7A, WNT10A, BMP2, FZD5",0.0545314148681803,0,FALSE +"H1648","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.3335,-1.14,0.265,17073,0.625,"GTF2B, GTF2A1, TAF9, STON1, TAF1, TAF11, TAF9B, TAF12",0.576754126063192,0.204119982655925,FALSE +"H1648","Input","KEGG_BASE_EXCISION_REPAIR",0.4702,1.42,0.0763,5907,0.487,"MUTYH, POLB, NEIL1, MBD4, POLL, PARP3, POLD4, SMUG1, PARP2, POLE2, UNG, POLE, APEX1, OGG1",1.11747546204512,0.312471038785366,FALSE +"H1648","Input","KEGG_BETA_ALANINE_METABOLISM",-0.36707,-1.34,0.117,18214,0.659,"HIBCH, SMS, ACADM, ALDH1B1, ALDH9A1",0.931814138253838,0.18111458540599,FALSE +"H1648","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.32236,-1.23,0.159,17624,0.734,"ELOVL2, FADS2, ACOT7, HACD1",0.798602875679548,0.134303940083929,FALSE +"H1648","Input","KEGG_BLADDER_CANCER",0.45711,1.37,0.0917,1484,0.521,"MMP9, FGFR3, E2F1, CXCL8, MMP1, CDH1, EGF, VEGFC, BRAF",1.03763066432998,0.283162276700476,FALSE +"H1648","Input","KEGG_BUTANOATE_METABOLISM",0.24511,0.729,0.851,2914,1,"AKR1B10, BDH1, L2HGDH, GAD1, AACS",0.0700704399154121,0,FALSE +"H1648","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.39009,1.18,0.227,4804,0.672,"NFKBIA, CARD11, IKBKB, DAPP1, LYN, PLCG2, NFATC4, NFKBIE, PIK3CB, RAC2, PTPN6, CHP2, PIK3AP1, MAP2K1, VAV1, SYK, NFKB1, PIK3CA, BLNK, BCL10, IKBKG, NFATC2, VAV3, RAC1, RELA, NFAT5, CD72",0.643974142806877,0.172630726946175,FALSE +"H1648","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.27697,0.821,0.721,3884,1,"DRD5, HTR7, LTB4R2, VDAC3, GNA15, PTAFR, P2RX5, PLCG2, ADRA1B, ADRB2, CALML6, GRIN2D, RYR3, ADCY4, CHP2, PLCB3, GRIN1, CHRM3, PTK2B, ADORA2A, P2RX6, SLC25A5, NOS3, CACNA1F, SLC25A31, ADCY3, SPHK1, CALML5, ERBB3, PHKG2, P2RX4, ATP2A2, ITPR3",0.142064735280571,0,FALSE +"H1648","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.20876,0.626,0.958,2974,1,"UQCRFS1, COX6B2, CACNB1, TNNI3, COX5A, CYC1, UQCRHL, CACNA1F, CACNB4, UQCRB",0.0186344909214556,0,FALSE +"H1648","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.42651,1.28,0.154,2286,0.601,"CLDN18, CD6, ITGAM, CLDN9, SELL, SELP, CLDN10, CLDN8, NECTIN1, ICOSLG, CDH3, CLDN20, CD40, ITGB2, CDH1, CLDN7, CLDN3, ITGB8, CLDN23, CLDN4, NRCAM, ICAM2, CLDN1, OCLN, SDC1",0.812479279163537,0.22112552799726,FALSE +"H1648","Input","KEGG_CELL_CYCLE",-0.28219,-1.03,0.397,16874,0.791,"MAD2L2, CDC23, CDC25B, CCND2, E2F2, CDKN2D, SMC3, YWHAE, ABL1, ORC3, BUB3, SMC1A, SKP1, SKP2, CCNH, CDKN2B, RBX1, DBF4, CDKN2A, ORC2, CDKN2C, TFDP1, ANAPC13, CDC25C, CDC16, ANAPC10, SMAD2",0.401209493236885,0.101823516502323,FALSE +"H1648","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.41843,1.27,0.149,3342,0.578,"CXCL10, CXCL9, CXCL11, CXCL6, CXCL3, CX3CL1, CCL5, NFKBIA, CCL22, CCR3, CXCL1, CXCL2, CCL20, IKBKB, LYN, CCL28, PF4, CCL17, CXCL8, GRK6, CCL19, FOXO3, CXCL16, BRAF, PIK3CB, GRK7, PPBP, CCL3, RAC2, GRK2, ADCY4, PLCB3, MAP2K1, PTK2B, VAV1, PAK1, CCL26, ADCY6, PRKCZ, TIAM1, PTK2, CSK, ADCY3, NFKB1, CXCR6, STAT2, CCR7, CCL3L3",0.826813731587726,0.238072161579471,FALSE +"H1648","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.33339,1.01,0.415,5756,0.901,"NFKBIA, IKBKB, E2F1, BCR, SMAD3, BRAF, PIK3CB, RUNX1, CBLC, MAP2K1, HDAC2, MECOM, BAD, TGFB3, NFKB1, PIK3CA, MYC, TGFBR2, IKBKG, STAT5A, RELA, TGFB2, CDK6, RAF1, HDAC1, STAT5B, BCL2L1, TGFB1, CCND1, MAP2K2, SHC2",0.381951903287907,0.045275209020937,FALSE +"H1648","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.47974,1.44,0.0573,3056,0.545,"NR1D1, BHLHE41, BHLHE40, PER1, CSNK1E",1.24184537803261,0.263603497723358,FALSE +"H1648","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.31856,-1.17,0.262,18284,0.673,"MDH1, OGDH, ACO1, SDHC",0.581698708680255,0.171984935776023,FALSE +"H1648","Input","KEGG_COLORECTAL_CANCER",-0.23639,-0.849,0.628,17100,0.84,"AXIN2, RHOA, APC, TCF7L1, BCL2, PIK3R1, AKT3, TGFBR1, MAPK8, SMAD2",0.202040356262804,0.0757207139381184,FALSE +"H1648","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.37195,1.12,0.286,4100,0.719,"C9, CFB, THBD, PROC, C5AR1, PLAU, SERPINF2, VWF, PLAT, C3, F5, F3, F12, FGG, PLAUR, SERPINA5, CFH, SERPINA1",0.543633966870957,0.143271109617117,FALSE +"H1648","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.28336,0.864,0.662,879,1,"AHCY, IL4I1, AMD1, SDS",0.1791420105603,0,FALSE +"H1648","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.51645,1.56,0.0309,3922,0.498,"CXCL10, IFNL1, IFNL3, CRLF2, IFNB1, CXCL9, CXCL11, IFNL2, CXCL6, CXCL3, CX3CL1, CCL5, IL23A, CCL22, IFNGR1, CSF2, CCR3, IL1R2, LTB, CXCL1, TNFSF18, CD27, TNFRSF18, CXCL2, CCL20, CSF3, IL20RA, CCL28, PF4, IL9R, CCL17, MET, CXCL8, IL1A, BMPR1B, IL4R, CD40, CCL19, TNFRSF21, CXCL16, BMP7, EGF, VEGFC, IL15RA, TNFRSF10A, TNFSF13, CSF2RA, PPBP, CCL3, IL6, BMP2, IL18, IL10RB, INHBE, TNFRSF14, TNFRSF1B, IFNLR1, CSF1, IL19, CCL26, PDGFB, AMH, NGFR, TNFSF15, TNF, PDGFA, TGFB3, CXCR6, IL1R1, CCR7, IL20RB, CSF1R, CCL3L3, TNFSF14, LTBR, IL22RA1, IFNAR2, LIF, RELT, TGFBR2, INHBB, TNFSF10, TNFRSF10D",1.51004152057517,0.302770657240282,FALSE +"H1648","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.56446,1.7,0.016,2184,0.762,"CXCL10, IFNB1, RIPK3, CCL5, NFKBIA, DDX58, IKBKE, IKBKB, IRF7, IL6, IRF3, IL18",1.79588001734408,0.1180450286604,FALSE +"H1648","Input","KEGG_DILATED_CARDIOMYOPATHY",0.22268,0.664,0.936,3111,1,"ITGB6, CACNB1, TNNI3, ITGA2, ITGB4, ITGB8, ADCY4, LAMA2, ADCY6, CACNA1F, CACNB4, TNF, ITGAV, TGFB3, ADCY3",0.0287241512618947,0,FALSE +"H1648","Input","KEGG_DNA_REPLICATION",0.272,0.815,0.746,5279,1,"RNASEH2C, RNASEH1, RFC4, POLD4, MCM2, RPA4, MCM5, MCM7, POLE2, RFC5, POLA2, POLE",0.127261172527331,0,FALSE +"H1648","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.39202,1.17,0.25,2350,0.671,"ETV6, ETV7, PIWIL4, NOTCH3, MAP2K1",0.602059991327962,0.173277479831008,FALSE +"H1648","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.31734,0.949,0.538,5269,0.973,"ADH7, CYP2E1, ALDH3A1, CYP2D6, ALDH1A3, GSTM1, GSTO2, CYP2C18, GSTT2, GSTK1, ALDH3B2, MGST1, MAOA, ADH1A, GSTP1, MGST2, GSTM3",0.269217724333611,0.0118871597316481,FALSE +"H1648","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.33408,0.999,0.423,4726,0.908,"XDH, UMPS, NAT1, UPP1, HPRT1, GMPS, GUSB, UCKL1, TYMP, CDA, IMPDH1",0.373659632624958,0.0419141514789149,FALSE +"H1648","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.28407,0.856,0.672,3805,1,"ITGB6, LAMC2, CHAD, LAMA3, ITGA2, AGRN, LAMB3, CD47, ITGB4, ITGB8, VWF, SDC1, THBS4, LAMA2, ITGAV, SDC4, LAMA5, THBS1, HMMR",0.172630726946175,0,FALSE +"H1648","Input","KEGG_ENDOCYTOSIS",0.323,0.97,0.483,4228,0.973,"ITCH, SRC, RAB11FIP1, CHMP4B, EPN3, TFRC, MET, FGFR3, CLTB, HGS, GRK6, SMURF1, ARAP1, ACAP3, EGF, ADRB2, ACAP2, ARAP3, RUFY1, GRK7, CHMP6, GRK2, VPS37B, PSD4, CBLC, RAB11FIP4, CHMP4C, IGF1R, IQSEC1, CLTA, ASAP2, ARAP2, VPS37C, PRKCZ, LDLR, CHMP4A, SH3GLB2, GIT1, ARF6, RAB11A, CSF1R, ERBB3, HSPA1B, AP2M1, HSPA1A, RAB22A, FGFR2, WWP1, ACAP1, AGAP2, DNM2",0.316052869248488,0.0118871597316481,FALSE +"H1648","Input","KEGG_ENDOMETRIAL_CANCER",0.18238,0.552,0.991,3622,1,"CDH1, FOXO3, EGF, BRAF, PIK3CB, MAP2K1, BAD, PIK3CA, MYC",0.00392634551472468,0,FALSE +"H1648","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.51814,1.56,0.0269,4862,0.498,"ATP6V0D2, CCL5, SRC, NFKBIA, ATP6V1C2, CXCL1, IKBKB, LYN, MET, CXCL8, PLCG2, ADAM17, MAPK9, TCIRG1, MAPK13, PTPRZ1, ATP6V0E1, HBEGF, TJP1, ATP6V0A2, PAK1, MAPK10, MAP3K14, ATP6V0B, F11R, ATP6V1H, CSK, NFKB1, GIT1, ATP6V0E2, NOD1, ATP6V1C1, ATP6V1A, IKBKG, ADAM10, RAC1, RELA, MAPK12, EGFR",1.57024771999759,0.302770657240282,FALSE +"H1648","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.39761,1.18,0.214,3664,0.672,"SRC, EREG, NCK1, BTC, AREG, PLCG2, PAK6, EGF, BRAF, PIK3CB, MAPK9, PAK2, EIF4EBP1, HBEGF, CBLC, TGFA, MAP2K1, PAK1, MAPK10, RPS6KB2, BAD, PTK2, ERBB3, PIK3CA, MYC, MTOR",0.669586226650809,0.172630726946175,FALSE +"H1648","Input","KEGG_ETHER_LIPID_METABOLISM",0.2868,0.861,0.66,5129,1,"PLA2G4E, LPCAT4, PLA2G4B, PLA2G10, PLPP3, PLPP2, PLA2G12A, AGPS, PLD2, PLA2G2F, LPCAT2, PLD1",0.180456064458131,0,FALSE +"H1648","Input","KEGG_FATTY_ACID_METABOLISM",-0.23858,-0.879,0.59,18120,0.842,"HADH, ACADM, ALDH1B1, ACAA2, ECI2, ALDH9A1",0.229147988357856,0.0746879085003505,FALSE +"H1648","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.31999,0.967,0.502,4757,0.969,"PLA2G4E, CSF2, LYN, PLCG2, PIK3CB, MAPK9, MAPK13, RAC2, PLA2G4B, PLA2G10, MAP2K1, VAV1, MAPK10, SYK, TNF, PIK3CA, PLA2G12A, LAT, PLA2G2F, VAV3, RAC1, PRKCD, MAPK12",0.299296282854981,0.0136762229492347,FALSE +"H1648","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.26203,0.788,0.799,5129,1,"PLA2G4F, PLA2G4E, LYN, PLCG2, PIK3CB, RAC2, PLA2G4B, MAP2K1, VAV1, PAK1, ASAP2, SYK, PLPP3, RPS6KB2, LIMK2, PLPP2, SPHK1, ARF6, PIK3CA, MYO10, DNM2, LAT, PLD2, PLA2G4D, VAV3, RAC1, PRKCD, WASL, RAF1, PLD1",0.0974532206860086,0,FALSE +"H1648","Input","KEGG_FOCAL_ADHESION",0.25253,0.763,0.809,3032,1,"SRC, BIRC3, DIAPH1, ITGB6, MET, LAMC2, CHAD, LAMA3, ITGA2, LAMB3, PAK6, EGF, VEGFC, BRAF, PIK3CB, MAPK9, ITGB4, ITGB8, PAK2, RAC2, ARHGAP5, VWF, MAP2K1, VAV1, THBS4, LAMA2, CAV2, PAK1, IGF1R, MAPK10, PDGFB, BAD, ITGAV, PDGFA, PTK2",0.0920514783877277,0,FALSE +"H1648","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.48535,-1.73,0.00769,12183,0.2,"GGH, ALPI, GCH1, DHFR, ALPG, ALPP, ALPL",2.11407366019857,0.698970004336019,TRUE +"H1648","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.46895,1.42,0.0672,5512,0.487,"AKR1B10, MTMR1, PFKL, FBP2, MPI, PFKFB4, ALDOC, GMPPB, PFKFB2, TPI1, KHK, ALDOA, GMDS, HK2, PFKFB3, AKR1B1, PFKP, HK1",1.17263072694617,0.312471038785366,FALSE +"H1648","Input","KEGG_GALACTOSE_METABOLISM",0.39746,1.19,0.224,6475,0.689,"GLA, GALT, PFKL, GANC, GAA, GALE, HK2, AKR1B1, PGM2, PFKP, HK1, B4GALT2, HK3, B4GALT1",0.649751981665837,0.161780778092374,FALSE +"H1648","Input","KEGG_GAP_JUNCTION",-0.2056,-0.734,0.821,14131,0.914,"PRKCB, MAPK1, TUBB6, DRD1, GNAS, TUBB2B, ADCY2, GUCY1B1, ADCY1, TUBB8, PDGFRA, DRD2, KRAS, GUCY1A2, MAPK7, TUBA3D, CDK1, TUBB4A, PRKG1, PDGFD, TUBA1B, PRKACA, PDGFRB, TUBA8, TUBB2A, ADCY9, PRKACB, ITPR2, PLCB4, TUBB3, LPAR1, TUBB, NRAS, GNAQ, GNAI1, TUBA1A",0.0856568428805592,0.0390538042661686,FALSE +"H1648","Input","KEGG_GLIOMA",0.24531,0.738,0.843,3664,1,"E2F1, PLCG2, EGF, BRAF, PIK3CB, CALML6, TGFA, MAP2K1, IGF1R, PDGFB, PDGFA, CALML5, PIK3CA, MTOR",0.0741724253752577,0,FALSE +"H1648","Input","KEGG_GLUTATHIONE_METABOLISM",0.44987,1.36,0.107,3859,0.525,"G6PD, GPX2, GSS, GGT6, GSR, OPLAH, GGT1, PGD, GPX3, GSTM1, GSTO2, GSTT2, GCLM, GGCT, GGT7, GSTK1, MGST1",0.97061622231479,0.279840696594043,FALSE +"H1648","Input","KEGG_GLYCEROLIPID_METABOLISM",0.36643,1.1,0.299,5958,0.716,"DGAT1, LIPG, GLA, MBOAT2, DGKQ, AGPAT3, DGKA, DGAT2, AKR1A1, PLPP3, GPAT3, PLPP2, DGKG, DGKE, MBOAT1, CEL, DGKH, ALDH3A2, AGPAT2, AKR1B1, AGPAT4, TKFC, GLYCTK, GPAT4",0.52432881167557,0.145086977692144,FALSE +"H1648","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40692,1.21,0.198,4873,0.645,"PLA2G4E, PISD, LPCAT4, LYPLA1, PTDSS1, PCYT1A, CHKB, MBOAT2, PGS1, PLA2G4B, PLA2G10, DGKQ, AGPAT3, DGKA, PLPP3, GPAT3, PLPP2, DGKG, DGKE, MBOAT1, CDS1, PLA2G12A, GPD2, PCYT2, ACHE, DGKH, PLD2, PLA2G2F, LPCAT2, LYPLA2, AGPAT2",0.703334809738469,0.190440285364732,FALSE +"H1648","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.32615,-1.17,0.235,16750,0.673,"CTH, DMGDH, PHGDH, PSPH, GNMT, GLDC, PSAT1, SRR",0.628932137728264,0.171984935776023,FALSE +"H1648","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.3453,1.04,0.39,6874,0.846,"ADH7, ALDH3A1, ALDH1A3, PFKL, FBP2, AKR1A1, ALDOC, PKM, DLAT, ALDH3B2, GPI, TPI1, LDHAL6B, ALDOA, GAPDH, HK2, ALDH3A2, ADH1A, ACSS2, GALM, PGM2, PFKP, LDHB, HK1, ADH6, PGAM1, LDHA, HK3, ALDH2, PCK2, ALDH3B1, FBP1",0.408935392973501,0.0726296369609765,FALSE +"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.36842,1.1,0.317,3293,0.716,"B4GALT7, CHST11, B3GALT6, DSE, XYLT2, CHST15, CSGALNACT1",0.498940737782249,0.145086977692144,FALSE +"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.28866,0.873,0.644,3227,1,"HS3ST1, B4GALT7, HS6ST2, B3GALT6, XYLT2, EXT1",0.191114132640188,0,FALSE +"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.34764,1.04,0.397,3626,0.846,"B3GNT7, CHST6, CHST4, FUT8, B4GALT4",0.401209493236885,0.0726296369609765,FALSE +"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.43688,1.32,0.106,5562,0.569,"HYAL4, IDS, SGSH, GUSB, HGSNAT, HYAL3, HEXA, HYAL1, IDUA, NAGLU, HPSE",0.97469413473523,0.244887733604929,FALSE +"H1648","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.19525,-0.705,0.913,14842,0.911,"ST3GAL2, ST8SIA1, ST8SIA5, B4GALNT1, ST6GALNAC3",0.039529222465701,0.0404816230270017,FALSE +"H1648","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.53022,1.6,0.0339,2720,0.673,"GLA, FUT2, B3GALT5, FUT1, A4GALT",1.46980030179692,0.171984935776023,FALSE +"H1648","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.49605,1.51,0.0481,3986,0.46,"ABO, B3GNT3, FUT3, FUT2, B3GALT5, B3GNT4, B3GNT5, FUT1, FUT4, B4GALT4, ST3GAL4, GCNT2",1.31785492362617,0.337242168318426,FALSE +"H1648","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.38619,1.16,0.242,4959,0.685,"PIGU, PIGB, PIGZ, PIGX, GPAA1, PIGQ, PIGS, PIGO, PIGL, PIGH, PIGW",0.616184634019569,0.164309428507574,FALSE +"H1648","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.60637,-2.27,0,17388,0.0907,"MTHFD2, HYI, MDH1, ACO1, GRHPR",Inf,1.0423927129399,TRUE +"H1648","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.26855,0.819,0.732,5175,1,"MAP3K4, SRC, PLA2G4E, MAPK9, MAPK13, CALML6, ADCY4, PLA2G4B, PLCB3, PLA2G10, HBEGF, MAP2K1, PTK2B, MAPK10, ADCY6, CACNA1F, ADCY3, MMP14, CALML5, MAP3K2, ITPR3, PLA2G12A, LHB, PLD2, PLA2G2F, PRKCD, MAPK12, CAMK2G, EGFR, ADCY7, RAF1, PLD1, MAP3K1",0.135488918941608,0,FALSE +"H1648","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.38487,1.15,0.257,2957,0.673,"IL1A, IL6, TNF",0.590066876668705,0.171984935776023,FALSE +"H1648","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.21478,-0.767,0.709,16454,0.878,"BMP8A, BMP8B, HHIP, BMP6, PRKACA, WNT2B, GAS1, PRKACB, GLI2, SUFU, WNT5A, GLI3, CSNK1G3, RAB23",0.149353764816933,0.0565054840938974,FALSE +"H1648","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.42186,1.27,0.136,3286,0.578,"ITGAM, CSF2, IL1R2, CSF3, TFRC, IL9R, IL1A, ITGA2, IL4R, CSF2RA, IL6, CD9, CSF1, TNF, IL1R1, CSF1R",0.866461091629782,0.238072161579471,FALSE +"H1648","Input","KEGG_HISTIDINE_METABOLISM",0.42285,1.27,0.139,4814,0.578,"LCMT1, ALDH3A1, ALDH1A3, TRMT11, HNMT, ACY3, ALDH3B2, HEMK1, MAOA, HAL, AOC1, ALDH3A2",0.856985199745905,0.238072161579471,FALSE +"H1648","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.41424,1.23,0.184,3359,0.618,"EME1, RAD51B, RAD51, MUS81, XRCC2, RAD51D, MRE11, RAD54L, POLD4, RAD54B, RPA4",0.735182176990464,0.209011524911184,FALSE +"H1648","Input","KEGG_HUNTINGTONS_DISEASE",-0.21836,-0.789,0.789,17299,0.856,"POLR2G, DCTN2, CLTCL1, CREB3L1, UQCRQ, RCOR1, HIP1, NDUFB3, PLCB4, PPARGC1A, COX7A2, AP2S1, BDNF, NDUFA8, CREB3L2, NDUFA7, NDUFA4, NDUFS4, GNAQ, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, APAF1, COX6B1, NDUFB2, SDHC, DCTN1, ATP5MC2, NDUFS5",0.10292299679058,0.0675262353228468,FALSE +"H1648","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.25701,0.773,0.81,3041,1,"ITGB6, CACNB1, TNNI3, ACE, ITGA2, ITGB4, ITGB8, IL6, LAMA2, CACNA1F, CACNB4, TNF, ITGAV, TGFB3",0.0915149811213502,0,FALSE +"H1648","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.27439,0.818,0.74,5554,1,"INPP4A, PLCG2, IPMK, PIK3CB, INPP4B, PLCB3, SYNJ2, PIK3C2B, IPPK, PIK3C2G, PIK3CA, OCRL, TPI1, ISYNA1, INPP5K, PIP4K2C, PLCD3, INPP5E, INPPL1",0.130768280269024,0,FALSE +"H1648","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.21936,0.666,0.924,7068,1,"IKBKB, PYGL, BRAF, PIK3CB, MAPK9, MKNK1, CALML6, FOXO1, EIF4EBP1, FBP2, CBLC, MAP2K1, MAPK10, RPS6KB2, BAD, SH2B2, PRKCZ, CALML5, TRIP10, PTPRF, PRKAR1B, PHKG2, PIK3CA, MTOR, SOCS2, ACACA, INSR, MKNK2, IRS1, HK2, PRKAB1, INPP5K, SOCS1, PPP1R3D, PHKG1, RAF1, EXOC7, HK1, SOCS3, MAP2K2, SHC2, FASN, PHKA1, TSC2, SOS1, PRKCI, HK3, PRKAA1, CRKL, SOS2, GYS1, LIPE, INPP5D, PYGM, PRKAG2, PCK2, FBP1, FLOT2, PHKA2, CALM2",0.0343280287798933,0,FALSE +"H1648","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.51136,1.56,0.0337,4573,0.498,"PIGR, CCL28, ICOSLG, CD40, IL15RA, TNFSF13, IL6, MAP3K14, LTBR, MADCAM1, IL15",1.47237009912866,0.302770657240282,FALSE +"H1648","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.40928,1.24,0.166,4604,0.607,"IFNL1, IFNL3, CRLF2, IFNB1, IFNL2, IL23A, IFNGR1, CSF2, CSF3, IL20RA, IL9R, SPRY3, IRF9, IL4R, PIK3CB, IL15RA, CSF2RA, SPRY1, PTPN6, IL6, CBLC, IL10RB, IFNLR1, IL19, STAT6, TYK2, STAT2, IL20RB, PIK3CA, IL22RA1, MYC, IFNAR2, LIF, SOCS2, CCND3, IFNGR2, PIM1, JAK3, CLCF1, OSMR, STAT5A, IL15, SOCS7",0.779891911959945,0.216811308924742,FALSE +"H1648","Input","KEGG_LEISHMANIA_INFECTION",0.46633,1.4,0.0794,3125,0.513,"ITGAM, NFKBIA, IFNGR1, TLR2, IL1A, NCF4, ITGB2, TAB2, MAPK13, PTPN6, C3, IRAK1, CYBA, TNF, TGFB3, MYD88, NFKB1",1.1001794975729,0.289882634888184,FALSE +"H1648","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.42995,1.3,0.136,3977,0.566,"MMP9, CLDN18, ITGAM, CLDN9, CLDN10, CLDN8, NCF4, CLDN20, PLCG2, ITGB2, CLDN7, CTNND1, PIK3CB, CLDN3, AFDN, MAPK13, CLDN23, RAC2, CLDN4, ARHGAP5, CLDN1, OCLN, PTK2B, VAV1, EZR, RAPGEF3, F11R, CYBA, PTK2, SIPA1, PIK3CA, NOX1, NCF2, RASSF5, TXK, PXN",0.866461091629782,0.247183568811729,FALSE +"H1648","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.5,-1.81,0.0142,18443,0.213,"ALDH1B1, ALDH9A1",1.84771165561694,0.671620396561262,TRUE +"H1648","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.61142,1.82,0.00349,2088,0.549,"AKR1B10, PLA2G4E, CYP2E1, CYP2J2, PLA2G4B, PLA2G10, CYP2C18",2.45717457304082,0.260427655549908,FALSE +"H1648","Input","KEGG_LONG_TERM_DEPRESSION",0.18565,0.56,0.991,2608,1,"PLA2G4E, LYN, BRAF, PLA2G4B, PLCB3, PLA2G10, MAP2K1, IGF1R",0.00392634551472468,0,FALSE +"H1648","Input","KEGG_LONG_TERM_POTENTIATION",-0.27282,-1.01,0.393,16947,0.773,"CALM1, RAP1B, PRKACA, PRKACB, ITPR2, CAMK4, RPS6KA2, PLCB4, RPS6KA1, ATF4, NRAS, GNAQ, CALM3, PPP3CB, PPP3R1",0.405607449624573,0.111820506081675,FALSE +"H1648","Input","KEGG_LYSINE_DEGRADATION",-0.29843,-1.11,0.289,17259,0.626,"SETDB1, EHMT1, HADH, ALDH1B1, AASS, OGDH, ALDH9A1, NSD1",0.539102157243452,0.20342566678957,FALSE +"H1648","Input","KEGG_LYSOSOME",0.42184,1.26,0.165,6147,0.571,"CTSE, ATP6V0D2, AP3M2, GGA2, NAPSA, LAMP3, CTSS, GLA, LAPTM5, IDS, ABCB9, MANBA, CLTB, IGF2R, CD164, CTSH, GGA3, TCIRG1, AP3B2, GM2A, AP1S3, CTSV, ATP6V0A2, SGSH, CLTA, ATP6V0B, GUSB, SLC11A2, CTSA, ATP6V1H, AP4S1, AP1M2, HGSNAT, GAA, ENTPD4, MFSD8, SUMF1, CTSD, LGMN, ACP5, GNPTG, SORT1, HEXA, CTSB, HYAL1, IDUA, M6PR, MAN2B1, ATP6V0C, CTSC, NAGLU, ARSA, ARSG, NPC1, NPC2, AP3D1, PSAP, LAPTM4B, LIPA, GGA1, FUCA1, CLN5, CTSZ",0.782516055786094,0.243363891754152,FALSE +"H1648","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.28446,0.85,0.671,3822,1,"MAP3K4, PLA2G4E, IL1R2, FGF17, IKBKB, DUSP5, CACNB1, DUSP10, NFKB2, FGFR3, DUSP9, NTF4, IL1A, GADD45A, FGF11, FGF13, NFATC4, RELB, RASGRP1, TAB2, EGF, BRAF, MAPK9, MAPK13, MKNK1, MAP3K13, PAK2, RAC2, MAP3K8, RPS6KA4, PLA2G4B, CHP2, PLA2G10, MAP2K1, RASA2, TRAF2, DUSP7, PAK1, MAPK10, MAP3K14, MAPKAPK5, MAPKAPK3, MECOM, CACNA1F, MAPK8IP3, CACNB4, PDGFB, GADD45B, TNF, PDGFA, TGFB3, NFKB1, IL1R1, STK3, MAP3K2, MAP3K5, MAP4K1, HSPA1B, MYC, MAP4K4, TGFBR2, HSPA1A, FGFR2",0.173277479831008,0,FALSE +"H1648","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.43762,1.32,0.109,2498,0.569,"HES1, MNX1, HNF1B, HNF4G, FOXA2",0.962573502059376,0.244887733604929,FALSE +"H1648","Input","KEGG_MELANOGENESIS",0.20532,0.619,0.956,3376,1,"WNT9A, DVL1, DVL3, WNT7A, WNT10A, CALML6, ADCY4, PLCB3, MAP2K1, FZD5, ADCY6, ASIP, ADCY3, CALML5, CREB3, FZD6",0.0195421077238999,0,FALSE +"H1648","Input","KEGG_MELANOMA",0.30215,0.91,0.595,3017,1,"FGF17, MET, E2F1, FGF11, FGF13, CDH1, EGF, BRAF, PIK3CB, MAP2K1, IGF1R, PDGFB, BAD, PDGFA",0.22548303427145,0,FALSE +"H1648","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.43184,1.3,0.13,4142,0.566,"ADH7, CYP2E1, AKR1C2, CYP1A1, ALDH3A1, AKR1C3, ALDH1A3, GSTM1, GSTO2, CYP2C18, AKR1C1, GSTT2, CYP1B1, GSTK1, ALDH3B2, MGST1, CYP2S1",0.886056647693163,0.247183568811729,FALSE +"H1648","Input","KEGG_MISMATCH_REPAIR",-0.19457,-0.712,0.825,19056,0.924,"RPA2",0.0835460514500749,0.0343280287798933,FALSE +"H1648","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.26238,0.787,0.778,4058,1,"ULK1, RICTOR, VEGFC, BRAF, PIK3CB, EIF4EBP1, RPS6KB2, ULK3, STK11, PIK3CA, MTOR, HIF1A",0.109020403010311,0,FALSE +"H1648","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.32157,0.965,0.501,4750,0.949,"IFNB1, IFNGR1, CSF2, PLCG2, ITGB2, NFATC4, BRAF, PIK3CB, SH3BP2, TNFRSF10A, RAC2, ICAM2, PTPN6, CHP2, MAP2K1, PTK2B, VAV1, PAK1, SYK, TNF, LCK, PIK3CA, IFNAR2, TNFSF10, TNFRSF10D, IFNGR2, TNFRSF10C, TNFRSF10B, LAT, NFATC2, CD244, VAV3, RAC1, NFAT5",0.300162274132754,0.0227337875727074,FALSE +"H1648","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.34881,1.04,0.405,2809,0.846,"DRD5, GALR2, NPBWR1, GABRP, S1PR4, HTR7, P2RY6, MC3R, P2RY2, LTB4R2, LTB4R, GABRG2, MTNR1A, PTAFR, P2RX5, C5AR1, GABRE, S1PR5, TSHB, ADRA1B, ADRB2, GRIN2D, SSTR2, GRIN1, VIPR1, CHRM3, ADORA2A, PRSS1, P2RX6, GRIN3B, GIPR, CHRNB1, GABRA3",0.392544976785331,0.0726296369609765,FALSE +"H1648","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.24207,0.728,0.86,4853,1,"NFKBIA, IRAK2, IKBKB, NTF4, PLCG2, FOXO3, BRAF, NFKBIE, PIK3CB, MAPK9, MAPK13, CALML6, RPS6KA4, MAP2K1, IRAK1, PRDM4, MAPK10, BAD, NGFR, SH2B2, CSK, NFKB1, CALML5, PSEN1, MAP3K5, RIPK2, PIK3CA, ZNF274, SORT1, RAC1, RELA, IRS1, PRKCD, MAPK12, IRAK3, CAMK2G, YWHAZ",0.0655015487564323,0,FALSE +"H1648","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.32396,0.965,0.485,4624,0.949,"NADK, NAMPT, NADSYN1, NMNAT3, PNP, NT5C1B, NT5C2, QPRT, NT5E",0.314258261397736,0.0227337875727074,FALSE +"H1648","Input","KEGG_NITROGEN_METABOLISM",0.28304,0.862,0.671,4648,1,"CA13, CA7, GLUD1, GLUL, HAL, GLS2",0.173277479831008,0,FALSE +"H1648","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.48837,1.47,0.062,3916,0.497,"CCL5, NFKBIA, BIRC3, CXCL1, TNFAIP3, CXCL2, IKBKB, CXCL8, TAB2, MAPK9, MAPK13, IL6, PSTPIP1, IL18, CARD6, MAPK10, NOD2, TNF, NFKB1, NLRP1, TAB3, RIPK2, NOD1, CARD9",1.20760831050175,0.303643611266668,FALSE +"H1648","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.3414,-1.28,0.118,15827,0.665,"XRCC6, XRCC4, NHEJ1, RAD50, XRCC5",0.928117992693875,0.177178354696895,FALSE +"H1648","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.26511,0.808,0.749,5702,1,"E2F1, PLCG2, FOXO3, EGF, BRAF, PIK3CB, TGFA, MAP2K1, BAD, RXRA, PIK3CA, RASSF5, CDK6, EGFR, RAF1, CCND1, ERBB2, MAP2K2",0.125518182300534,0,FALSE +"H1648","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.51853,1.56,0.0392,2688,0.498,"DVL1, DVL3, DTX4, RFNG, DTX3L, JAG1, ADAM17, DLL1, HES1, HES5, NOTCH3, DTX2, JAG2, KAT2A, HDAC2",1.40671393297954,0.302770657240282,FALSE +"H1648","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.38986,-1.37,0.0811,15123,0.674,"RFC1, XPA, GTF2H1, ERCC4, RAD23B, GTF2H4, RPA1, RFC2, ERCC1, RAD23A, ERCC6, ERCC2, ERCC8, CCNH, RBX1, XPC, CUL4A, RPA2",1.09097914578884,0.17134010346468,FALSE +"H1648","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.26447,0.79,0.79,4552,1,"ALG3, MGAT4B, RFT1, RPN2, RPN1, MGAT1, ALG10, ALG10B, FUT8, MAN2A2, MOGS, DPAGT1, MGAT2, TUSC3, ALG8",0.102372908709559,0,FALSE +"H1648","Input","KEGG_OLFACTORY_TRANSDUCTION",0.38106,1.14,0.255,1976,0.675,"OR4C6, OR2J3, OR5M11, OR8S1, OR6B2, OR13D1, OR1J1, OR4D2, OR13H1, OR10AD1, OR2A5, OR4L1, OR2D2, OR11H4, OR10K2, OR2A7, OR4X2, OR1G1, OR10H1, OR8G1, OR2A12, OR8B4, GUCY2D, CALML6, OR8G5, OR6A2, OR10G3, OR8B8, OR4K1",0.593459819566045,0.170696227168975,FALSE +"H1648","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.22828,-0.803,0.726,14026,0.872,"ATIC, DHFR, FTCD, TYMS, MTHFD2, MTR",0.139063379299906,0.0594835150674328,FALSE +"H1648","Input","KEGG_OOCYTE_MEIOSIS",-0.31904,-1.13,0.311,16772,0.613,"CPEB1, MAD2L2, CDC23, CALM1, PRKACA, SMC3, YWHAE, ADCY9, FBXO43, PRKACB, ITPR2, RPS6KA2, RPS6KA1, SMC1A, SKP1, PPP2R1A, RBX1, CALM3, SGO1, ANAPC13, PPP3CB, PPP2R5C, CDC25C, PPP2R5D, CDC16, PPP3R1, ANAPC10",0.507239610973163,0.212539525481585,FALSE +"H1648","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.49486,1.49,0.042,6273,0.477,"MANBA, ENGASE, MAN2C1, FUCA2, HEXA, MAN2B1, MAN2B2, FUCA1, NEU1",1.3767507096021,0.321481620959886,FALSE +"H1648","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.23704,-0.817,0.661,18279,0.863,"NDUFA8, NDUFA7, NDUFA4, NDUFS4, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, ATP5ME, COX6B1, NDUFB2, ATP6V1E1, SDHC, ATP5MC2, NDUFS5",0.17979854051436,0.0639892042847904,FALSE +"H1648","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.51195,1.52,0.0492,3145,0.47,"ST6GALNAC1, GCNT3, B4GALT5, GALNT7, GALNT5, GALNT12, GALNT10, GALNT3, GALNT6, GALNT18, GALNT14",1.30803489723264,0.327902142064283,FALSE +"H1648","Input","KEGG_P53_SIGNALING_PATHWAY",0.24741,0.746,0.834,6303,1,"ATR, GADD45A, SERPINB5, CD82, PERP, TP53I3, GADD45B, PMAIP1, SFN, EI24, RPRM, THBS1, CCND3, CYCS, TNFRSF10B, GADD45G, CDK6, IGFBP3, STEAP3, CCND1, BID, TP73, PIDD1, CHEK1, TSC2, CDKN1A, FAS",0.0788339493622613,0,FALSE +"H1648","Input","KEGG_PANCREATIC_CANCER",0.29184,0.897,0.605,5629,1,"IKBKB, E2F1, SMAD3, EGF, VEGFC, BRAF, PIK3CB, MAPK9, RAD51, RAC2, TGFA, MAP2K1, MAPK10, BAD, TGFB3, NFKB1, PIK3CA, RALB, TGFBR2, IKBKG, RALGDS, RAC1, RELA, TGFB2, CDK6, EGFR, BRCA2, RAF1, PLD1, BCL2L1, TGFB1, CCND1, ERBB2",0.218244625347531,0,FALSE +"H1648","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.22684,0.685,0.895,5025,1,"PPCDC, COASY, PANK4, PANK3, PANK2",0.048176964684088,0,FALSE +"H1648","Input","KEGG_PARKINSONS_DISEASE",-0.26648,-0.986,0.397,18279,0.739,"NDUFA8, PINK1, NDUFA7, NDUFA4, NDUFS4, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, APAF1, COX6B1, NDUFB2, SDHC, PARK7, ATP5MC2, NDUFS5",0.401209493236885,0.131355561605174,FALSE +"H1648","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.31553,-1.15,0.219,16110,0.678,"TUBA3D, ROCK1, YWHAQ, TUBB4A, CD14, ACTB, TUBA1B, ARHGEF2, TUBA8, RHOA, TUBB2A, ABL1, TLR4, TUBB3, FYN, TUBB, ARPC5, TUBA1A, CDC42",0.659555885159882,0.168770306132937,FALSE +"H1648","Input","KEGG_PATHWAYS_IN_CANCER",0.28487,0.85,0.679,3822,1,"MMP9, WNT9A, NFKBIA, DVL1, BIRC3, FGF17, IKBKB, TRAF4, DVL3, NFKB2, MET, FGFR3, E2F1, BCR, CXCL8, LAMC2, SMAD3, LAMA3, WNT7A, ITGA2, PLCG2, FGF11, FGF13, LAMB3, MMP1, PML, CDH1, EGLN3, EGF, VEGFC, WNT10A, JUP, BRAF, PIK3CB, MAPK9, CSF2RA, FOXO1, RUNX1, RAD51, RAC2, TRAF1, IL6, BMP2, CBLC, TGFA, PAX8, MAP2K1, TRAF2, VHL, LAMA2, FZD5, IGF1R, MAPK10, HDAC2, MECOM, PDGFB, BAD, ITGAV, PDGFA, PTK2, TGFB3, NFKB1, CSF1R, FZD6, LAMA5, RXRA, PIK3CA, MYC, MTOR, ELOC, TFG, RALB, TGFBR2, WNT3, FGFR2",0.168130225719498,0,FALSE +"H1648","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.26823,0.809,0.758,2843,1,"UGDH, RPEL1, GUSB",0.120330794367946,0,FALSE +"H1648","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.50757,1.52,0.0525,5444,0.47,"G6PD, PGD, TKT, TALDO1, RPEL1, PFKL, FBP2, ALDOC, DERA, GPI, ALDOA, PGM2, PFKP",1.27984069659404,0.327902142064283,FALSE +"H1648","Input","KEGG_PEROXISOME",0.23246,0.707,0.884,5121,1,"XDH, SOD2, ACSL5, PRDX5, PEX2, SLC27A2, PEX5, PRDX1, DDO, ACAA1, MVK, PAOX, ABCD1, GSTK1, EPHX2, PEX3, MLYCD, EHHADH, AGPS, DHRS4, SOD1, PEX7, PEX16, NUDT19, ACOT8, ACOX1",0.0535477349869269,0,FALSE +"H1648","Input","KEGG_PHENYLALANINE_METABOLISM",0.55315,1.66,0.0255,4365,0.573,"IL4I1, ALDH3A1, AOC2, ALDH1A3, ALDH3B2, MAOA, AOC3",1.59345981956604,0.24184537803261,FALSE +"H1648","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25378,0.764,0.8,3949,1,"INPP4A, PLCG2, PIK3CB, INPP4B, CALML6, PLCB3, DGKQ, DGKA, SYNJ2, PIK3C2B, CALML5, DGKG, DGKE, IPPK, PIK3C2G, PIK3CA, CDS1, ITPR3, OCRL",0.0969100130080564,0,FALSE +"H1648","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.34428,1.03,0.399,3373,0.865,"CP, EARS2, FTH1, GUSB, ALAS1, HMOX2",0.399027104313252,0.0629838925351858,FALSE +"H1648","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.18465,0.562,0.988,5588,1,"FABP6, MMP1, ACSL5, SLC27A4, ME1, SLC27A2, ACAA1, RXRA, CPT2, UBC, CYP27A1, EHHADH, ANGPTL4, CPT1C, ACOX1, CPT1A, ACSL1, SLC27A1, PPARG",0.00524305541237188,0,FALSE +"H1648","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.28189,0.843,0.694,4036,1,"CH25H, CYP7B1, AKR1D1, CYP27A1",0.158640529545145,0,FALSE +"H1648","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.38015,1.15,0.244,5251,0.673,"CD40, CIITA, ADA, TAP2, LCK, BLNK, IKBKG, JAK3, RAG2, UNG, TAP1",0.612610173661271,0.171984935776023,FALSE +"H1648","Input","KEGG_PRION_DISEASES",0.30397,0.937,0.526,2350,0.983,"CCL5, C9, IL1A, IL6, MAP2K1",0.279014255846261,0.00744648216786438,FALSE +"H1648","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28281,-1,0.36,16258,0.734,"CDK1, PDE3A, ARAF, CPEB1, MAD2L2, CDC23, CDC25B, PRKACA, ADCY9, PRKACB, RPS6KA2, RPS6KA1, PDE3B, PIK3R1, AKT3, MAPK14, GNAI1, ANAPC13, CDC25C, CDC16, MAPK8, ANAPC10",0.443697499232713,0.134303940083929,FALSE +"H1648","Input","KEGG_PROPANOATE_METABOLISM",-0.28276,-1,0.418,14863,0.734,"ABAT, PCCA, SUCLA2, SUCLG1, ACSS1, LDHC, ACACB, HIBCH, ACADM, ALDH1B1, ALDH9A1",0.378823718224965,0.134303940083929,FALSE +"H1648","Input","KEGG_PROSTATE_CANCER",0.23981,0.717,0.872,5702,1,"NFKBIA, IKBKB, E2F1, EGF, BRAF, PIK3CB, FOXO1, TGFA, MAP2K1, IGF1R, PDGFB, BAD, PDGFA, NFKB1, CREB3, PIK3CA, MTOR, FGFR2, IKBKG, RELA, CREB5, EGFR, GSTP1, RAF1, TCF7, CCND1, ERBB2, MAP2K2",0.0594835150674328,0,FALSE +"H1648","Input","KEGG_PROTEASOME",0.27494,0.823,0.731,3211,1,"PSME4, PSME2, PSMB11, PSME1, PSMD11, PSMF1, PSMA5, PSMD2, PSMB5, PSMB10, PSMA6",0.13608262304214,0,FALSE +"H1648","Input","KEGG_PROTEIN_EXPORT",0.271,0.807,0.739,4969,1,"OXA1L, SRPRA, SEC63, SRP54, SRPRB, SEC11A, SEC62, SRP68, SEC61A1",0.131355561605174,0,FALSE +"H1648","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.16518,0.503,0.994,5399,0.996,"SLC25A10, GLUD1, ATP1B3, GLS2, ATP1A3, ATP1B1",0.00261361560268669,0.00174066157630127,FALSE +"H1648","Input","KEGG_PURINE_METABOLISM",-0.19398,-0.665,0.914,16712,0.937,"POLR2D, NME7, NPR2, RRM2B, PDE1C, PDE7B, POLA1, PDE6B, PDE6G, POLR2G, PAPSS1, ADSL, ADCY9, PDE10A, PDE8B, PDE6D, APRT, PRUNE1, AK5, PDE3B, PDE4B, PRIM2, AK7, ENPP1, PAPSS2, NT5M, DCK, POLR3GL, DGUOK, POLR1E",0.0390538042661686,0.0282604091122217,FALSE +"H1648","Input","KEGG_PYRIMIDINE_METABOLISM",0.21269,0.636,0.95,5377,1,"ENTPD3, POLR2H, UMPS, CMPK2, TXNRD1, POLR1B, PNP, UPP1, NME6, NT5C1B, POLD4, ENTPD4, UCKL1, PNPT1, DUT, NT5C2, TYMP, CDA, POLE2, POLR1C, NT5E, CAD, CMPK1, POLA2, NT5C, POLE, ENTPD5, NME5",0.0222763947111523,0,FALSE +"H1648","Input","KEGG_PYRUVATE_METABOLISM",-0.23207,-0.861,0.617,18284,0.861,"MDH1, ALDH1B1, ALDH9A1, GRHPR",0.209714835966758,0.0649968485463452,FALSE +"H1648","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.25971,0.778,0.801,3219,1,"ITGAM, FGF17, PFN4, DIAPH1, ITGB6, ARHGEF4, FGFR3, TMSB4Y, ITGA2, FGF11, FGF13, ITGB2, PAK6, EGF, BRAF, PIK3CB, BAIAP2, ITGB4, ITGB8, SSH3, MYH14, PAK2, RAC2, CHRM3, SSH1, MAP2K1, VAV1, FGD3, EZR, PAK1, ITGAX, PDGFB, ITGAV, TIAM1, LIMK2, PDGFA, PTK2, CSK, GIT1",0.0963674839157623,0,FALSE +"H1648","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.24812,0.753,0.859,1482,1,"ULK1, ATG5, PIK3R4, BECN1",0.0660068361687577,0,FALSE +"H1648","Input","KEGG_RENAL_CELL_CARCINOMA",0.22262,0.669,0.933,5045,1,"MET, PAK6, EGLN3, VEGFC, BRAF, PIK3CB, PAK2, TGFA, MAP2K1, VHL, PAK1, PDGFB, TGFB3, PIK3CA, ELOC, HIF1A, RAC1, TGFB2, ETS1, RAF1",0.0301183562535,0,FALSE +"H1648","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.25357,0.765,0.812,5920,1,"ACE, CTSA, REN, THOP1, ACE2",0.0904439707588247,0,FALSE +"H1648","Input","KEGG_RETINOL_METABOLISM",0.46555,1.39,0.0915,5135,0.515,"RDH16, ADH7, CYP1A1, DHRS9, DGAT1, RDH10, CYP26A1, CYP2C18, DHRS3, DGAT2, ALDH1A2, CYP26B1, LRAT, DHRS4, BCO1, ADH1A, DHRS4L2, ALDH1A1, RDH11",1.03857890593355,0.288192770958809,FALSE +"H1648","Input","KEGG_RIBOFLAVIN_METABOLISM",0.24282,0.733,0.866,5743,1,"MTMR1, ACP6, ACP4, ACP5, ACP1, FLAD1",0.0624821079826534,0,FALSE +"H1648","Input","KEGG_RIBOSOME",-0.51374,-1.88,0.0222,16296,0.202,"RPL9, RPL26, RPL24, RPS4X, RPL10A, RPL3, RPS24, RPS18, RPS13, RPS15, RPL7A, RPL34, UBA52, RPL21, RPL13A, RPS23, RPL27A, RPL6, RPL29, RPL5, RPL11, RPSA, RPL37A, RPL18, RPL35, RPS19, RPS16, RSL24D1, RPS9, RPS5, RPS11, RPS6, RPS27L, RPS10, RPS15A, RPS27, RPL17",1.65364702554936,0.694648630553376,TRUE +"H1648","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.46961,1.43,0.0733,3125,0.54,"CXCL10, IFNB1, NFKBIA, DDX58, IKBKE, IKBKB, CXCL8, ATG5, DDX3Y, TRADD, ISG15, DHX58, IRF7, MAPK9, MAPK13, IRF3, IFIH1, TRAF2, MAPK10, TNF, NFKB1",1.13489602535887,0.267606240177031,FALSE +"H1648","Input","KEGG_RNA_DEGRADATION",-0.35043,-1.28,0.138,17144,0.665,"PAPOLG, DCP2, PAPOLA, EXOSC8, MPHOSPH6, XRN2, LSM3, LSM7, TTC37, LSM2, ENO1, EXOSC3, C1D, ZCCHC7",0.860120913598763,0.177178354696895,FALSE +"H1648","Input","KEGG_RNA_POLYMERASE",-0.25521,-0.942,0.527,14661,0.821,"POLR2C, POLR2L, POLR2J3, POLR2I, POLR2F, POLR2D, POLR2G, POLR3GL, POLR1E",0.278189384787453,0.0856568428805592,FALSE +"H1648","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.45765,1.38,0.0967,4199,0.519,"LCMT1, AHCY, GGT6, GGT1, TRMT11, GGT7, AHCYL1, HEMK1, MAT2B",1.014573525917,0.284832642151542,FALSE +"H1648","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.30031,0.897,0.604,3622,1,"NFKBIA, BIRC3, IKBKB, TRAF4, E2F1, LAMC2, LAMA3, ITGA2, LAMB3, PIK3CB, TRAF1, TRAF2, LAMA2, ITGAV, PTK2, NFKB1, LAMA5, RXRA, PIK3CA, MYC",0.218963061378868,0,FALSE +"H1648","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.25951,-0.926,0.476,17365,0.806,"USE1, STX8, SNAP25, VAMP5, STX2, SEC22B, VAMP3, STX12",0.322393047279507,0.0936649581949093,FALSE +"H1648","Input","KEGG_SPHINGOLIPID_METABOLISM",0.32506,0.964,0.497,3712,0.939,"SMPD2, GLA, SGPP2, ACER3, DEGS2, PLPP3, PLPP2, SPHK1, UGT8, SGMS2",0.303643611266668,0.0273344077338891,FALSE +"H1648","Input","KEGG_SPLICEOSOME",0.24679,0.756,0.836,1835,1,"LSM8, SRSF6, CTNNBL1, PRPF40B, SART1, SRSF5, THOC3, U2SURP, AQR, RBM22, ACIN1, PRPF38B, NCBP2, TCERG1, TRA2B, RBM25, ZMAT2, PRPF38A, SRSF2, ISY1",0.0777937225609836,0,FALSE +"H1648","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.20729,0.628,0.962,3831,1,"UGDH, PYGL, GANC, GUSB, UXS1, GAA, GPI",0.0168249279621871,0,FALSE +"H1648","Input","KEGG_STEROID_BIOSYNTHESIS",-0.23238,-0.824,0.635,14250,0.872,"MSMO1, HSD17B7, SOAT1, CYP27B1, LSS, CYP51A1",0.197226274708024,0.0594835150674328,FALSE +"H1648","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.47261,1.42,0.0843,4006,0.487,"AKR1C2, CYP1A1, AKR1C3, HSD17B3, AKR1C1, SRD5A1, CYP7B1, CYP1B1, AKR1D1, SRD5A3, HSD11B1, HSD11B2, HSD17B8, SULT2B1",1.07417242537526,0.312471038785366,FALSE +"H1648","Input","KEGG_SULFUR_METABOLISM",0.4448,1.34,0.106,4113,0.558,"SULT1A4, SULT1A1, CHST11, SULT1A2, SULT2B1, SUOX",0.97469413473523,0.253365801062421,FALSE +"H1648","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.22043,0.666,0.932,2957,1,"C9, CD40, C3, TNF",0.0305840876460186,0,FALSE +"H1648","Input","KEGG_TASTE_TRANSDUCTION",0.39248,1.17,0.235,5194,0.671,"SCNN1G, SCNN1B, TAS1R3, TAS2R31, SCNN1A, ADCY4, ADCY6, ITPR3, GNB1, TAS2R20, TAS2R4, TAS2R5, GNG3, TAS2R13, TAS2R19, TAS2R10",0.628932137728264,0.173277479831008,FALSE +"H1648","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.63202,1.92,0.00348,3251,0.56,"GGT6, GGT1, GAD1, GGT7",2.45842075605342,0.2518119729938,FALSE +"H1648","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.61874,-2.2,0,17922,0.0644,"HMGCR, IDI1, DHDDS, FDPS, GGPS1, PMVK",Inf,1.19111413264019,TRUE +"H1648","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.28043,-1.01,0.376,16153,0.773,"ROCK1, SMAD5, BMP8A, THBS2, RBL2, BMP8B, NOG, ID4, BMPR1A, CHRD, BMP6, ACVR2A, DCN, RHOA, SMAD9, SKP1, PPP2R1A, CDKN2B, ZFYVE16, RBX1, TFDP1, TGFBR1, BMPR2, LTBP1, SMAD2",0.424812155072339,0.111820506081675,FALSE +"H1648","Input","KEGG_THYROID_CANCER",0.25693,0.773,0.821,5702,1,"CDH1, BRAF, PAX8, MAP2K1, RXRA, MYC, TFG, TCF7, PPARG, CCND1, CCDC6, MAP2K2",0.0856568428805592,0,FALSE +"H1648","Input","KEGG_TIGHT_JUNCTION",0.33873,1.02,0.408,2982,0.883,"CLDN18, SRC, CLDN9, CLDN10, CLDN8, CGN, PRKCH, CLDN20, HCLS1, PPP2R2C, TJP3, CLDN7, CLDN3, AFDN, MYH14, CLDN23, EPB41L1, CRB3, CLDN4, CLDN1, OCLN, TJP1, MYH7B, YBX3, LLGL2, F11R, PPP2R2A, PRKCZ",0.38933983691012,0.0540392964224314,FALSE +"H1648","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.50914,1.54,0.0322,3623,0.504,"CXCL10, IFNB1, CXCL9, CXCL11, CCL5, NFKBIA, IRF5, TLR6, IKBKE, TLR1, TLR2, IKBKB, CXCL8, CD40, TAB2, IRF7, PIK3CB, MAPK9, MAPK13, CCL3, MAP3K8, IL6, TICAM1, IRF3, TLR5, MAP2K1, IRAK1, MAPK10, TNF, MYD88, NFKB1, TLR3, PIK3CA, IFNAR2",1.49214412830417,0.297569463554475,FALSE +"H1648","Input","KEGG_TRYPTOPHAN_METABOLISM",0.3607,1.1,0.308,517,0.716,"KYNU, IL4I1, CYP1A1, IDO1, KMO",0.511449283499556,0.145086977692144,FALSE +"H1648","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29189,0.861,0.68,5887,1,"IKBKB, PIK3CB, MAPK9, MAPK10, TNF, PRKCZ, PKM, PIK3CA, MTOR, SOCS2, INSR, IRS1, HK2, PRKCD, SOCS1, HK1, SOCS3, PRKCE",0.167491087293764,0,FALSE +"H1648","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.25809,0.764,0.812,2957,1,"IL1A, GAD1, TNF",0.0904439707588247,0,FALSE +"H1648","Input","KEGG_TYROSINE_METABOLISM",0.44025,1.31,0.121,4885,0.576,"LCMT1, ADH7, IL4I1, ALDH3A1, AOC2, ALDH1A3, TRMT11, ALDH3B2, HEMK1, MAOA, AOC3, FAH, ADH1A",0.91721462968355,0.239577516576788,FALSE +"H1648","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.3545,1.06,0.361,4757,0.824,"NFKBIA, CSF2, CARD11, IKBKB, NCK1, DLG1, NFATC4, PAK6, RASGRP1, NFKBIE, PIK3CB, MAPK9, MAPK13, PAK2, MAP3K8, PTPN6, CHP2, CBLC, MAP2K1, VAV1, PAK1, MAP3K14, TNF, NFKB1, TEC, LCK, PIK3CA, BCL10, IKBKG, LAT, NFATC2, VAV3, RELA, NFAT5, MAPK12",0.442492798094342,0.0840727883028842,FALSE +"H1648","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.19754,0.594,0.972,6114,1,"ITCH, BIRC3, UBE2J2, SMURF1, UBR5, PML, FBXO2, SYVN1, UBE2G2, UBE3C, CBLC, FBXW11, VHL, ANAPC7, UBE2L6, UBE2Z, UBE2K, ANAPC5, BRCA1, UBE2H, RNF7, BIRC6, HERC2, ANAPC4, ELOC, WWP1, UBA7, UBE2W, UBE2O, FZR1, ANAPC2, UBE4A, DDB1, UBE3B, SOCS1, UBA6, MAP3K1, ANAPC1, CDC34, HERC1, SOCS3, RHOBTB2, KEAP1, UBE3A, KLHL13, PIAS1, UBE2C, UBE2A, XIAP",0.0123337350737254,0,FALSE +"H1648","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.48196,-1.75,0.0227,14636,0.223,"BCAT2, VARS2, IARS2, PDHB",1.64397414280688,0.651695136951839,TRUE +"H1648","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.26043,-0.938,0.5,14302,0.804,"HMGCS2, HADHB, BCAT2, ACADSB, ABAT, OXCT1, PCCA, HMGCL, HSD17B10, BCKDHB, HIBADH, AOX1, HADH, HIBCH, ACADM, ALDH1B1, ACAA2, ALDH9A1",0.301029995663981,0.0947439512515487,FALSE +"H1648","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.17472,0.535,0.991,3255,0.998,"PLA2G4E, KCNMB3, PRKCH, ADRA1B, BRAF, CALML6, ADCY4, PLA2G4B, PLCB3, PLA2G10, MAP2K1, ADORA2A, ADCY6, CACNA1F, ADCY3, CALML5",0.00392634551472468,0.000869458712628891,FALSE +"H1648","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.3318,-1.22,0.168,15891,0.697,"AVPR2, DCTN4, DYNC1LI1, RAB5B, PRKACA, DCTN2, ADCY9, PRKACB, CREB3L1, ARHGDIA, DYNLL1, CREB3L2, DCTN6, DYNC1I2, DCTN1",0.774690718274137,0.156767221901991,FALSE +"H1648","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.31218,0.939,0.54,5910,0.99,"SRC, PLA2G4E, PLCG2, NFATC4, PIK3CB, MAPK13, RAC2, PLA2G4B, CHP2, PLA2G10, MAP2K1, NOS3, MAPKAPK3, BAD, PTK2, SPHK1, PIK3CA, PXN, PLA2G12A, NFATC2, PLA2G2F, RAC1, NFAT5, MAPK12, RAF1, PTGS2, CHP1, MAPK11, MAP2K2, SHC2, PLA2G6",0.267606240177031,0.00436480540245009,FALSE +"H1648","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.36553,1.1,0.305,4492,0.716,"ATP6V0D2, ATP6V1C2, KCNQ1, ERO1A, PLCG2, TCIRG1, ATP6V0E1, TJP1, ATP6V0A2, ATP6V0B, ATP6V1H, ADCY3, ATP6V0E2, SLC12A2, ATP6V1C1, ATP6V1A, TJP2",0.515700160653214,0.145086977692144,FALSE +"H1648","Input","KEGG_VIRAL_MYOCARDITIS",0.20176,0.606,0.972,4621,1,"EIF4G1, CD40, ITGB2, MYH14, RAC2, MYH7B, LAMA2, MYH11, CXADR, CYCS, CAV1, RAC1",0.0123337350737254,0,FALSE +"H1648","Input","KEGG_WNT_SIGNALING_PATHWAY",0.25713,0.769,0.816,4389,1,"MMP7, TBL1Y, WNT9A, DVL1, DVL3, CHD8, CSNK1A1, SENP2, PORCN, TBL1XR1, SMAD3, WNT7A, NKD2, NFATC4, WNT10A, MAPK9, CTNNBIP1, RAC2, CHP2, PLCB3, FBXW11, FZD5, RUVBL1, MAPK10, CSNK1E, FRAT2, SFRP5, FZD6, PSEN1, CSNK1A1L, MYC, WNT3, VANGL1, CCND3, VANGL2, LRP5, WNT7B, NFATC2",0.0883098412461389,0,FALSE +"H2126","Input","KEGG_ABC_TRANSPORTERS",0.36567,1.09,0.341,3789,0.917,"ABCG2, ABCG1, ABCC2, ABCC3, ABCD1, ABCB8, ABCD4, ABCB7, ABCA12, ABCB6",0.467245621007502,0.0376306643299789,FALSE +"H2126","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.22193,-0.757,0.795,15187,0.943,"PIK3CD, MAP2K1, PPARD, CEBPA, EIF4EBP1, CCNA1, LEF1, PIK3R1, RAF1, PIM1, PIM2, TCF7, BAD, HRAS, PML, NRAS, AKT3",0.0996328713435297,0.0254883072626717,FALSE +"H2126","Input","KEGG_ADHERENS_JUNCTION",-0.23621,-0.87,0.603,17317,0.805,"SNAI2, VCL, CDC42, RHOA, TCF7, ACTN1, ACTG1, CSNK2B, FER, NECTIN3, ACTB, FYN, WASF1",0.219682687859849,0.0942041196321315,FALSE +"H2126","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.42392,1.24,0.175,4364,0.766,"PRKAB1, IRS2, CPT1B, PRKAG1, TRAF2, STAT3, ADIPOR1, PRKAA2, ACSL1, PPARA, ACSL3, IKBKB, RELA, CAMKK2, RXRA, ACACB, TRADD, AKT1, PRKAB2, IKBKG, PRKAA1, CPT1C, TNFRSF1B, MTOR, TNFRSF1A",0.756961951313706,0.115771230367396,FALSE +"H2126","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.37403,1.1,0.302,4731,0.917,"AGXT, GPT, GLUL, GFPT1, CPS1, ALDH5A1, CAD, GLS2, ALDH4A1",0.519993057042849,0.0376306643299789,FALSE +"H2126","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.30824,0.904,0.604,4356,1,"IRS2, INS, SCNN1A, FXYD4, PIK3R3, ATP1B1, MAPK3, PRKCG, KCNJ1, MAPK1",0.218963061378868,0,FALSE +"H2126","Input","KEGG_ALLOGRAFT_REJECTION",-0.32815,-1.19,0.242,10722,0.714,"CD28, CD40LG, IL2, FASLG, IL12B, CD80, IL4, IL10, PRF1, CD86, TNF, GZMB, FAS, IL12A",0.616184634019569,0.146301788223826,FALSE +"H2126","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.52753,1.54,0.0458,4629,0.451,"PLA2G6, PLA2G12A, PLA2G10, ACOX3, PLA2G2D, PLA2G2C, PLA2G4A, PLA2G4B",1.33913452199613,0.345823458122039,FALSE +"H2126","Input","KEGG_ALZHEIMERS_DISEASE",0.18914,0.556,0.986,4587,1,"CASP9, ATP2A3, UQCR11, GRIN2D, EIF2AK3, GRIN1, CALML6, ITPR1, CACNA1D, NDUFV2, APH1A, NDUFA3, PSEN1, ERN1, APAF1, NDUFV1, IDE, COX6A1, NDUFA10, ATP5MC2, MAPK3, NDUFB1, ADAM10, NDUFA5, PLCB1, SDHA, UQCRHL, PSENEN, BID, MAPK1, TNFRSF1A, COX6A2, CACNA1F, GNAQ, SDHD",0.0061230850587888,0,FALSE +"H2126","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.29099,-1.09,0.277,16444,0.609,"WARS2, FARSB, LARS2, CARS2, RARS2, YARS2, PSTK",0.557520230935551,0.215382707367125,FALSE +"H2126","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.58332,1.72,0.0147,5813,0.652,"NANS, GMPPA, HK2, FPGT, GNPDA2, UGDH, GNPNAT1, GFPT1, GALK2, NANP, GMDS, PGM1, GNE, NPL, GMPPB, PGM3, PMM2, MPI, PGM2, CHIT1, HEXB, UGP2, GALT, GALE",1.83268266525182,0.18575240426808,FALSE +"H2126","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.21727,0.636,0.943,4364,1,"CASP9, GRIN2D, GRIN1, SLC1A2, MAP3K5, CCS, APAF1, BAX, MAPK13, DERL1, TNFRSF1B, BID, TNFRSF1A",0.0254883072626717,0,FALSE +"H2126","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.30656,0.909,0.593,4038,1,"CTSL, HSPA1L, CD4, LGMN, NFYC, TAPBP, IFI30, HSPA1A, CREB1, HSPA1B, HSPA2, KLRC3, PDIA3",0.226945306635737,0,FALSE +"H2126","Input","KEGG_APOPTOSIS",0.25302,0.73,0.87,4364,1,"CASP9, IRAK4, ATM, TRAF2, XIAP, IKBKB, AIFM1, RELA, CSF2RB, TRADD, PIK3R3, APAF1, BAX, AKT1, BIRC3, MYD88, IL1R1, IKBKG, BIRC2, BID, TNFRSF1A",0.0604807473813815,0,FALSE +"H2126","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.43071,1.28,0.141,3980,0.789,"CYP4A22, PTGES, PLA2G6, ALOX15B, PLA2G12A, CYP4F3, CYP2J2, PLA2G10, PTGES2, LTA4H, PTGDS, ALOX5, PLA2G2D, PTGS1, GPX2, EPHX2, ALOX12B, PLA2G2C, LTC4S, PLA2G4A, GPX3",0.85078088734462,0.10292299679058,FALSE +"H2126","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.2584,0.775,0.797,6291,1,"GLUL, SAT1, PYCR1, ALDH18A1, GATM, CKMT1A, CKMT1B, ALDH2, CPS1, ALDH3A2, P4HA3, ARG1, GLS2, AGMAT, MAOA, ALDH4A1, GAMT, ASS1, P4HA2, ASL, PYCR3, ODC1",0.0985416786038876,0,FALSE +"H2126","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.18921,0.554,0.987,4525,1,"CACNB2, CACNG1, CACNA1D, ITGB6, ITGB5, ITGA1, CACNG6, ITGA2B, JUP, DMD, ITGB1, DSP, CACNG8, CACNG4, CACNA1F",0.00568284733036327,0,FALSE +"H2126","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.25981,0.753,0.816,3745,1,"UGDH, ALDH2, ALDH3A2",0.0883098412461389,0,FALSE +"H2126","Input","KEGG_ASTHMA",0.25981,0.757,0.824,14150,1,"CD40, EPX, IL5, IL13, IL9, MS4A2, FCER1A, FCER1G, CD40LG, IL3, CCL11, PRG2, IL4, IL10, TNF, RNASE3",0.0840727883028842,0,FALSE +"H2126","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.27766,0.817,0.749,170,1,"CGA",0.125518182300534,0,FALSE +"H2126","Input","KEGG_AXON_GUIDANCE",0.21615,0.633,0.943,3790,1,"FES, RND1, SEMA4C, EFNA1, SRGAP1, EPHA1, SEMA3E, EFNA3, SEMA4B, NTN4, PLXNB2, PLXNA3, SEMA3B, PAK4, PAK6, EPHB6, EFNA4, RHOD, MAPK3, SRGAP3, EFNA5, ARHGEF12, ROCK1, ITGB1, SEMA4G",0.0254883072626717,0,FALSE +"H2126","Input","KEGG_BASAL_CELL_CARCINOMA",0.36601,1.08,0.337,1246,0.935,"WNT3A, FZD10, WNT4, WNT7B, WNT11",0.472370099128661,0.0291883891274822,FALSE +"H2126","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.3626,-1.27,0.135,17299,0.629,"GTF2H1, STON1, TAF9, GTF2E2, GTF2H3, TAF5, TAF7, GTF2B, TBPL1",0.869666231504994,0.201349354554731,FALSE +"H2126","Input","KEGG_BASE_EXCISION_REPAIR",0.27861,0.823,0.729,1281,1,"LIG3, SMUG1, NEIL1, MUTYH",0.137272471682025,0,FALSE +"H2126","Input","KEGG_BETA_ALANINE_METABOLISM",0.28488,0.841,0.723,3745,1,"AOC2, ACADM, AOC3, ALDH2, ALDH3A2",0.140861702705469,0,FALSE +"H2126","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.27539,0.806,0.727,2367,1,"ACOT4, ACOX3, ACOT1, ACOT2",0.138465589140962,0,FALSE +"H2126","Input","KEGG_BLADDER_CANCER",-0.31965,-1.19,0.18,15388,0.714,"MAP2K1, EGF, PGF, RASSF1, CXCL8, THBS1, CDKN1A, MMP1, RAF1, E2F2, E2F3, MMP2, TP53, CDKN2A, VEGFB, HRAS, NRAS, CDK4",0.744727494896694,0.146301788223826,FALSE +"H2126","Input","KEGG_BUTANOATE_METABOLISM",-0.27931,-1,0.388,16610,0.628,"PDHB, ACSM3, ALDH1B1, ECHS1, ACAT1, ALDH9A1, BDH2, OXCT1",0.411168274405793,0.202040356262804,FALSE +"H2126","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.23363,0.679,0.91,4005,1,"BLNK, VAV1, IKBKB, RELA, SOS2, CD72, PTPN6, PLCG2, PIK3R3, RASGRP3, AKT1, CD22, VAV2, MAPK3, CD19, IKBKG, SOS1",0.0409586076789064,0,FALSE +"H2126","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.32819,0.97,0.501,3057,1,"BDKRB2, CD38, ATP2A3, BDKRB1, CACNA1I, ADCY4, PHKA1, P2RX4, GRIN2D, RYR1, GRIN1, CALML6, ITPR1, ADRA1D, ATP2B1, SLC8A2, CACNA1D, PTAFR, P2RX2, ERBB2, GNA14, PHKA2, CAMK2G, LTB4R2, PLCG2, TACR3, TRHR, ERBB3, CACNA1A",0.300162274132754,0,FALSE +"H2126","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.27836,0.821,0.733,1492,1,"CACNB2, CACNG1, TNNI3, UQCR11, CACNA1D, SLC9A1",0.134896025358872,0,FALSE +"H2126","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.24197,0.706,0.882,3758,1,"CDH5, ITGB2, ICAM3, CD4, PTPRF, CNTN1, ICOSLG, CDH3, NRXN3, CLDN3, ITGAL, CLDN20, CLDN7, CDH1, CD40, F11R, CD22, CLDN4, PTPRM, OCLN, ITGB1",0.0545314148681803,0,FALSE +"H2126","Input","KEGG_CELL_CYCLE",-0.46269,-1.61,0.0347,16390,0.664,"GSK3B, MAD2L2, TTK, CCNA1, TFDP1, PTTG2, YWHAE, CCNE2, CDC20, MAD1L1, MCM5, CDKN1A, CDC25C, E2F2, MCM3, ANAPC13, TFDP2, E2F3, MCM2, RBL1, PRKDC, SKP1, PKMYT1, CCNH, MCM6, CDKN2B, TP53, CDK6, MAD2L1, CDKN2D, BUB1, CDKN2A, YWHAQ, CDC14A, GADD45A, CCNB2, CDKN1C, CDKN2C, PLK1, HDAC2, CDK1, CCNA2, CDC25A, MCM4, CDC7, ORC3, HDAC1, ORC6, BUB3, PTTG1, CDK4, CCNB1, SMC3, TGFB1",1.45967052520913,0.177831920631982,FALSE +"H2126","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.24171,0.711,0.875,4024,1,"CCL22, ADCY5, CCR7, CCL17, ADCY4, ARRB1, VAV1, JAK3, STAT3, CCR3, ARRB2, IKBKB, RELA, CXCL16, WASL, GRK2, SOS2, ADCY6, PIK3R3, STAT2, AKT1, CXCL3, VAV2, MAPK3, PREX1, STAT5B, CXCL2, PRKCD, ROCK1, IKBKG, CCL28, SOS1, TIAM1",0.0579919469776868,0,FALSE +"H2126","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.32338,-1.15,0.25,16866,0.566,"CDKN1A, PIK3R1, RAF1, E2F2, SHC2, E2F3, TP53, CDK6, CDKN2A, MECOM, BAD, HDAC2, HRAS, NRAS, AKT3, HDAC1, CDK4, TGFB1",0.602059991327962,0.247183568811729,FALSE +"H2126","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.57486,1.68,0.0148,5204,0.417,"CSNK1E, PER2, CSNK1D, NPAS2, CLOCK, CRY1, BHLHE40, BHLHE41",1.82973828460504,0.379863945026242,FALSE +"H2126","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.28756,0.845,0.708,4824,1,"SUCLG2, IDH3G, PC, IDH2, IDH3B, DLAT, SDHA, DLST, ACO2, SDHD, MDH2, PDHA1, IDH1",0.149966742310231,0,FALSE +"H2126","Input","KEGG_COLORECTAL_CANCER",-0.27994,-0.952,0.45,15119,0.667,"RAC1, PIK3CD, MSH6, MAP2K1, MLH1, SMAD3, TGFB3, GSK3B, LEF1, MAPK10, BIRC5, PIK3R1, RAF1, RHOA, TP53, BCL2, JUN, TCF7, BAD, AKT3, TGFB1",0.346787486224656,0.175874166083451,FALSE +"H2126","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.45314,1.33,0.109,1849,0.779,"FGA, BDKRB2, FGG, FGB, BDKRB1, CD55, C8G, PLG, TFPI",0.962573502059376,0.108462542327436,FALSE +"H2126","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.259,0.76,0.812,1369,1,"LDHC, TAT, CTH, AHCYL1",0.0904439707588247,0,FALSE +"H2126","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.19403,0.575,0.983,4429,1,"CCL22, CCR7, CCL17, INHBB, EPO, TNFSF11, IFNL3, IL9R, TNFRSF18, IL13RA1, TGFBR1, CCR3, BMP7, CXCL16, CSF2RB, GH2, PDGFB, CD40, TNFRSF25, TNFSF13, TNFSF15, CLCF1, EPOR, CXCL3, LTBR, KITLG, VEGFC, CXCL2, OSMR, IL20RA, IL1R1, CCL28, TNFRSF1B, VEGFA, TNFRSF1A, VEGFD, IFNL2, TPO",0.00744648216786438,0,FALSE +"H2126","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.2581,0.748,0.833,4933,1,"RIPK3, IRF3, IKBKB, RELA, ADAR, POLR3F, POLR3GL, TBK1, IKBKG, MAVS, CCL5, NFKBIB",0.0793549985932124,0,FALSE +"H2126","Input","KEGG_DILATED_CARDIOMYOPATHY",0.273,0.799,0.76,2736,1,"ADCY5, CACNB2, CACNG1, TNNI3, ADCY4, CACNA1D, ITGB6, ITGB5, ITGA1, ADCY6, CACNG6, ITGA2B",0.119186407719209,0,FALSE +"H2126","Input","KEGG_DNA_REPLICATION",-0.6495,-2.4,0,16205,0.0669,"POLE3, PCNA, RPA2, POLE, RFC1, MCM5, PRIM1, POLA2, POLA1, MCM3, RPA3, RNASEH2C, RFC5, MCM2, MCM6, RFC4, RFC2, FEN1, MCM4, PRIM2",Inf,1.17457388223218,TRUE +"H2126","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.43235,1.27,0.153,4847,0.713,"PIWIL2, ETS2, SPIRE2, NOTCH3, SOS2, MAPK3, SOS1, MAPK1, ETV7",0.815308569182401,0.146910470148134,FALSE +"H2126","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.42313,1.27,0.147,3429,0.713,"GSTA3, ALDH3B2, GSTK1, ALDH3B1, CYP2A7, CYP2A6, CYP2D6, GSTM5, GSTZ1, GSTA4, GSTO2, GSTM3, MGST1, FMO5, ALDH1A3",0.832682665251824,0.146910470148134,FALSE +"H2126","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.35672,1.04,0.369,1174,1,"CES1, TYMP, CYP2A7, GUSB, CYP2A6",0.43297363384094,0,FALSE +"H2126","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.24668,-0.859,0.646,14988,0.787,"COL4A4, GP1BB, ITGA7, ITGA9, COL11A1, ITGA11, RELN, COL5A3, COL6A3, THBS2, COL3A1, LAMA4, ITGAV, COL11A2, ITGB3, THBS1, COL1A2, COL4A6, SPP1, ITGA4, LAMA1, ITGB8, LAMA2, COL4A2, COL5A2, THBS4, SV2A, COL5A1, ITGA6, SDC2, FN1, TNC, COL6A2, HMMR, COL4A1",0.189767482004916,0.104025267640935,FALSE +"H2126","Input","KEGG_ENDOCYTOSIS",0.30523,0.903,0.604,3795,1,"CHMP1B, HSPA1L, ARFGAP3, PLD1, ARRB1, CHMP2A, ARFGAP1, USP8, PLD2, RAB11B, STAM2, ARRB2, CBLC, CHMP5, VPS45, EPN3, PIP5K1B, SMURF1, IQSEC2, VPS36, GRK2, ARAP2, SH3GLB2, AP2A1, TFRC, IGF1R, VPS28, CHMP3, RAB11FIP4, RAB31, ERBB3, HSPA1A, WWP1, PSD4, RAB5B, FGFR3, VPS37C, ASAP2, HSPA1B, CHMP2B, HSPA2, ITCH, CHMP4B",0.218963061378868,0,FALSE +"H2126","Input","KEGG_ENDOMETRIAL_CANCER",-0.21223,-0.721,0.852,15187,0.934,"PIK3CD, FOXO3, MAP2K1, MLH1, EGF, GSK3B, ELK1, LEF1, PIK3R1, RAF1, TP53, TCF7, BAD, HRAS, NRAS, AKT3",0.0695604052332999,0.0296531237699066,FALSE +"H2126","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.19245,0.57,0.982,5904,1,"ATP6V1B1, ATP6V0A4, ATP6AP1, IKBKB, RELA, TCIRG1, PLCG2, MAPK13, F11R, ATP6V0B, ADAM10, IKBKG, ATP6V0E2, ATP6V1G1, MAPK11, CCL5, PAK1, ATP6V1F, ATP6V1E2, IGSF5, NFKBIA, ADAM17, EGFR",0.00788851221305034,0,FALSE +"H2126","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.18735,0.553,0.984,4693,1,"GAB1, CBLC, ERBB2, BTC, CAMK2G, SOS2, PAK4, PAK6, PLCG2, PIK3R3, ERBB3, AKT1, MAP2K7, MAPK3, STAT5B, SOS1, PRKCG, MTOR, MAPK1, NRG4, AREG",0.00700490156865849,0,FALSE +"H2126","Input","KEGG_ETHER_LIPID_METABOLISM",0.49491,1.46,0.064,4713,0.587,"PLA2G6, PLD1, PAFAH2, PLD2, PLA2G12A, PLA2G10, PLPP3, PLA2G2D, PLA2G2C, PLA2G4A, PAFAH1B2, PLA2G4B, LPCAT1",1.19382002601611,0.231361898752386,FALSE +"H2126","Input","KEGG_FATTY_ACID_METABOLISM",0.3501,1.03,0.414,4233,1,"CYP4A22, CPT1B, ACADM, ACSL1, CPT2, ACSL3, ACOX3, ACADS, ALDH2, ALDH3A2, ACAA1, CPT1C, HADHB",0.382999658879101,0,FALSE +"H2126","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.27487,0.803,0.748,4709,1,"PLA2G6, VAV1, PLA2G12A, PLA2G10, SOS2, PLCG2, PLA2G2D, PIK3R3, MAPK13, AKT1, MAP2K7, PLA2G2C, VAV2, MAPK3, PRKCD, PLA2G4A, SOS1, MAPK1, PLA2G4B, VAV3, MAPK11",0.126098402135539,0,FALSE +"H2126","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.22207,0.648,0.936,4703,1,"PLA2G6, PLD1, VAV1, PLD2, PIP5K1B, PLPP3, WASL, ARPC1A, PLCG2, PIK3R3, AKT1, ARPC1B, VAV2, ASAP2, MAPK3, VASP, PRKCD, PLA2G4A, PRKCG, MYO10, MAPK1, PLA2G4F, WASF3, PLA2G4B, VAV3",0.0287241512618947,0,FALSE +"H2126","Input","KEGG_FOCAL_ADHESION",-0.27255,-0.997,0.419,14988,0.613,"COL4A4, ITGA7, ITGA9, RAC1, PIK3CD, COL11A1, CAV1, ACTN2, ITGA11, MAP2K1, RELN, EGF, COL5A3, SHC4, PGF, COL6A3, PDGFRA, THBS2, MYLK2, PRKCA, COL3A1, LAMA4, MYLPF, CCND2, SHC3, ITGAV, PAK3, MYL5, GSK3B, COL11A2, ITGB3, DOCK1, THBS1, PDGFRB, COL1A2, ELK1, COL4A6, SPP1, ITGA4, MAPK10, LAMA1, ITGB8, PIK3R1, RAF1, LAMA2, COL4A2, SHC2, VCL, FLNC, COL5A2, THBS4, CDC42, PARVA, COL5A1, RHOA, PPP1CC, MYL9, ITGA6, BCL2, JUN, MYLK, FN1, TNC, VEGFB, COL6A2, ACTN1, BAD, ACTG1, COL4A1, HRAS, PDGFC, AKT3, ACTB, FYN, FLNA",0.377785977033705,0.212539525481585,FALSE +"H2126","Input","KEGG_FOLATE_BIOSYNTHESIS",0.37341,1.11,0.291,3757,0.92,"PTS, GCH1, SPR, QDPR",0.536107011014093,0.0362121726544447,FALSE +"H2126","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.33426,0.99,0.472,3315,1,"GMPPA, FBP1, HK2, FPGT, PHPT1, GMDS, PFKFB2, GMPPB",0.326058001365912,0,FALSE +"H2126","Input","KEGG_GALACTOSE_METABOLISM",0.38366,1.13,0.271,5813,0.931,"HK2, B4GALT1, GAA, GALK2, PGM1, B4GALT2, GLA, MGAM, PGM2, GLB1, UGP2, GALT, G6PC2, GALE",0.567030709125594,0.0310503190186574,FALSE +"H2126","Input","KEGG_GAP_JUNCTION",-0.29855,-1.05,0.296,15131,0.667,"TUBA4A, DRD2, GNAI3, PLCB3, MAP2K1, EGF, PDGFRA, MAPK7, GUCY1A2, PRKCA, PRKG1, GUCY1A1, MAP3K2, PDGFRB, TUBB4A, ADCY1, RAF1, PRKACA, GUCY1B1, TUBB4B, TUBA1B, GJA1, TUBB2B, GNAI1, TUBA1A, HRAS, CDK1, NRAS, PDGFC, TUBB, ADCY7, TUBB6, GNAI2, TUBB2A",0.528708288941061,0.175874166083451,FALSE +"H2126","Input","KEGG_GLIOMA",-0.27635,-0.985,0.388,15187,0.616,"PIK3CD, MAP2K1, EGF, SHC4, PDGFRA, PRKCA, SHC3, PDGFRB, CDKN1A, PIK3R1, RAF1, E2F2, SHC2, E2F3, TP53, CDK6, CDKN2A, HRAS, CALM2, NRAS, AKT3, CDK4",0.411168274405793,0.210419287835575,FALSE +"H2126","Input","KEGG_GLUTATHIONE_METABOLISM",0.38098,1.12,0.286,3980,0.947,"GSTA3, GSTK1, TXNDC12, G6PD, GSTM5, GSTZ1, OPLAH, GSTA4, GSTO2, GSTM3, GCLC, MGST1, GPX2, IDH2, GSR, MGST2, GPX3",0.543633966870957,0.0236500209967266,FALSE +"H2126","Input","KEGG_GLYCEROLIPID_METABOLISM",0.26236,0.762,0.814,5940,1,"AKR1A1, DGAT1, PLPP3, TKFC, DGKE, MBOAT1, DGAT2, ALDH2, ALDH3A2, GLA, LCLAT1, GPAT4, DGKQ, AGPAT4, MGLL, GPAT2, PLPP2, AGK",0.0893755951107988,0,FALSE +"H2126","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40279,1.19,0.209,4713,0.87,"PISD, LPGAT1, PLA2G6, PLD1, CHKB, PLD2, PLA2G12A, CDS1, PLA2G10, PLPP3, PEMT, PLA2G2D, CRLS1, DGKE, MBOAT1, PLA2G2C, PLA2G4A, LCLAT1, GPAT4, DGKQ, PTDSS2, PLA2G4B, AGPAT4, LPCAT1",0.679853713888946,0.0604807473813815,FALSE +"H2126","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.395,1.14,0.272,5552,0.99,"AGXT, AOC2, CTH, AOC3, DMGDH, GATM, MAOA, AMT, SRR, GAMT, DLD, GCAT",0.565431095965801,0.00436480540245009,FALSE +"H2126","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.2415,0.711,0.882,5481,1,"ALDH3B2, ALDH3B1, LDHC, AKR1A1, FBP1, HK2, PGM1, GALM, ACSS2, PGAM2, ALDH2, ALDH1A3, ALDH3A2, DLAT, BPGM, PDHA1, PGM2, PGK2, LDHA, DLD, LDHAL6B",0.0545314148681803,0,FALSE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.27556,0.8,0.77,5075,1,"CSGALNACT1, XYLT1, B4GALT7, CHST11, CHST15, CHST12, XYLT2, CHSY1, CHPF",0.113509274827518,0,FALSE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.29535,0.848,0.688,2944,1,"XYLT1, HS6ST1, HS6ST2, HS6ST3, B4GALT7",0.162411561764489,0,FALSE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.50905,1.52,0.0412,2407,0.459,"B3GNT7, B4GALT4, ST3GAL1, B4GALT1, B3GNT2, CHST6",1.38510278396687,0.338187314462739,FALSE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.60147,1.79,0.00925,5672,0.661,"HGSNAT, NAGLU, HYAL1, IDUA, GUSB, HYAL4, GNS, HYAL2, GALNS, IDS, HEXB, GLB1, HPSE",2.03385826726097,0.17979854051436,FALSE +"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.23299,0.689,0.902,5605,1,"ST3GAL1, B3GALT4, SLC33A1, ST6GALNAC4, HEXB, GLB1",0.0447934624580583,0,FALSE +"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.45542,1.33,0.112,5491,0.779,"FUT2, ST3GAL1, NAGA, GBGT1, A4GALT, GLA, HEXB, FUT1",0.950781977329818,0.108462542327436,FALSE +"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.53373,1.56,0.0333,2364,0.485,"B4GALT4, ST3GAL4, FUT2, FUT3, B3GNT3, B4GALT1, ABO, B3GNT2",1.47755576649368,0.314258261397736,FALSE +"H2126","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.54041,1.59,0.0366,4759,0.458,"PIGO, PIGT, PIGF, PIGU, DPM2, GPAA1, PIGL, PIGH, PIGZ, PIGV, PIGK, GPLD1, PIGS, PIGB, PIGP",1.43651891460559,0.339134521996131,FALSE +"H2126","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.24867,0.727,0.858,5325,1,"MTHFD2L, AFMID, ACO2, MTHFD2, MDH2, GRHPR",0.0665127121512946,0,FALSE +"H2126","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.35081,1.03,0.396,4746,1,"ADCY5, CGA, MAP3K4, ADCY4, PLA2G6, PLD1, CALML6, ITPR1, CACNA1D, PLD2, PLA2G12A, PLA2G10, CAMK2G, SOS2, ADCY6, ATF4, PLA2G2D, MAPK13, MAP2K7, PLA2G2C, MAPK3, PRKCD, PLA2G4A, SOS1, PLCB1, MAPK1, CACNA1F, GNAQ, PLA2G4B, MAPK11, LHB",0.402304814074488,0,FALSE +"H2126","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.49648,-1.74,0.00787,10721,0.598,"KIR2DL1, CD28, KIR3DL2, IL2, KLRC1, KIR3DL1, KIR2DL3, FASLG, CD80, IL6, PRF1, CD86, TNF, GZMB, IL1A, IL1B, FAS",2.10402526764094,0.223298816011589,FALSE +"H2126","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.37973,1.11,0.282,1742,0.92,"WNT3A, CSNK1E, WNT4, WNT7B, BMP6, WNT11, BMP7, BMP8B",0.549750891680639,0.0362121726544447,FALSE +"H2126","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.32319,0.951,0.543,5962,1,"CD38, CD14, EPO, CD4, IL9R, CD55, ITGA1, TFRC, ITGA2B, EPOR, CD22, KITLG, CD19, IL1R1, GP1BA, TPO, CD37, CD5, IL1R2, IL4R, CD59, DNTT, IL7, FCGR1A, ITGA3",0.265200170411153,0,FALSE +"H2126","Input","KEGG_HISTIDINE_METABOLISM",0.52547,1.54,0.0431,636,0.451,"HAL, AMDHD1, ALDH3B2, ALDH3B1, BUD23",1.36552272983927,0.345823458122039,FALSE +"H2126","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.27595,0.813,0.766,7114,1,"RAD52, BLM, POLD4, MRE11, SEM1, XRCC3, NBN, TOP3B, BRCA2, EME1, RAD50, RAD54B, MUS81, XRCC2, POLD3, RAD51D",0.115771230367396,0,FALSE +"H2126","Input","KEGG_HUNTINGTONS_DISEASE",-0.28479,-1.02,0.381,16178,0.684,"NDUFB3, CLTB, DNALI1, DNAH1, SDHC, NDUFA8, COX6B2, UQCRQ, NDUFA2, DCTN4, VDAC2, NDUFB8, ATP5F1C, NDUFA9, NDUFAB1, SDHB, TFAM, POLR2D, AP2S1, COX4I1, TP53, BDNF, AP2M1, UQCRC1, NDUFB5, NDUFA1, CREB5, CLTA, HDAC2, ATP5MC3, ATP5PF, NDUFS3, COX8A, BBC3, ATP5PO, IFT57, HDAC1, NDUFS4, NDUFB6, TBPL1, ATP5F1A, HIP1, POLR2E, GPX1",0.419075024324381,0.164943898279884,FALSE +"H2126","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.28411,0.826,0.709,2736,1,"CACNB2, CACNG1, PRKAB1, TNNI3, PRKAG1, PRKAA2, CACNA1D, ITGB6, ITGB5, ITGA1, CACNG6, ITGA2B",0.149353764816933,0,FALSE +"H2126","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.24748,0.726,0.865,4850,1,"OCRL, ALDH6A1, INPP4A, PIP4K2C, PIP5K1B, ITPK1, PLCG2, PI4KB, INPP5B, INPPL1, INPP5K, IMPA2, PLCB1, PIK3C2A, IPMK",0.0629838925351858,0,FALSE +"H2126","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.35765,1.06,0.354,4207,0.99,"PRKAB1, IRS2, INS, PHKA1, PPP1R3B, PRKAG1, GYS1, CALML6, FBP1, HK2, PRKAA2, PTPRF, MKNK1, CBLC, PPP1R3D, IKBKB, SOCS2, TSC1, ACACB, PHKA2, SOS2, SREBF1, PPP1R3C, PIK3R3, PYGL, AKT1, RPTOR, FOXO1, FASN, ACACA, MAPK3, SOCS4, MKNK2, PRKAB2, PHKG1, PRKAA1, SOS1, INPP5K, MTOR",0.450996737974212,0.00436480540245009,FALSE +"H2126","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.23361,-0.809,0.653,15219,0.857,"MAP3K14, CXCL12, CCL27, IL15, CXCR4, ITGA4, CCR10, MADCAM1, TGFB1",0.185086818724926,0.0670191780768018,FALSE +"H2126","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.27339,0.805,0.755,4429,1,"EPO, SPRY3, IFNL3, JAK1, JAK3, IL9R, IL13RA1, STAT3, PIAS3, STAM2, CBLC, SOCS2, CSF2RB, SOS2, GH2, PTPN6, PIK3R3, SOCS7, STAT2, TYK2, AKT1, CLCF1, EPOR, STAT5B, SOCS4, EP300, OSMR, IL20RA, SOS1, IFNL2, STAT6, TPO",0.122053048370812,0,FALSE +"H2126","Input","KEGG_LEISHMANIA_INFECTION",0.23567,0.68,0.912,3758,1,"NCF4, ITGB2, JAK1, IRAK4, RELA, PTPN6, MAPK13, TAB1, MAPK3, MYD88, ITGB1",0.0400051616715838,0,FALSE +"H2126","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.25033,0.737,0.851,5306,1,"CDH5, NCF4, ITGB2, VAV1, RAPGEF4, RAPGEF3, CLDN3, CTNND1, ITGAL, CLDN20, CLDN7, PLCG2, PIK3R3, TXK, MAPK13, ARHGAP35, F11R, VAV2, CLDN4, VASP, RASSF5, OCLN, ROCK1, ITGB1, SIPA1, PRKCG, CLDN9, VAV3, MAPK11, PXN, CTNNA1, AFDN, CLDN8, CYBB",0.0700704399154121,0,FALSE +"H2126","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.41231,-1.47,0.0486,17832,0.557,"ALDH1B1, ECHS1, ALDH9A1",1.31336373073771,0.254144804826271,FALSE +"H2126","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.45089,1.32,0.115,5251,0.742,"PLA2G6, PLA2G12A, CYP2J2, PLA2G10, PLA2G2D, PLA2G2C, PLA2G4A, CYP3A43, PLA2G4B, ALOX15, CYP3A7",0.939302159646388,0.129596094720973,FALSE +"H2126","Input","KEGG_LONG_TERM_DEPRESSION",0.28697,0.84,0.704,4629,1,"PLA2G6, RYR1, ITPR1, PLA2G12A, PLA2G10, PRKG2, IGF1R, GNAO1, PLA2G2D, CACNA1A, PLA2G2C, MAPK3, PPP2R1B, PLA2G4A, PRKCG, PLCB1, MAPK1, GNAQ, PLA2G4B",0.152427340857888,0,FALSE +"H2126","Input","KEGG_LONG_TERM_POTENTIATION",0.24903,0.735,0.86,4541,1,"GRIN2D, GRIN1, CALML6, ITPR1, RPS6KA2, RPS6KA6, RAPGEF3, CAMK2G, ATF4, MAPK3, EP300, PRKCG, PLCB1, MAPK1, GNAQ",0.0655015487564323,0,FALSE +"H2126","Input","KEGG_LYSINE_DEGRADATION",0.23752,0.7,0.895,3759,1,"SETDB1, SETD7, EHMT1, KMT5B, ASH1L, KMT5C, AASDH, ALDH2, ALDH3A2, AASDHPPT",0.048176964684088,0,FALSE +"H2126","Input","KEGG_LYSOSOME",0.4666,1.35,0.0936,5816,0.787,"SLC11A1, HGSNAT, PPT1, GM2A, CTSL, NAGLU, ARSA, FUCA1, HYAL1, ATP6V0A4, IDUA, GUSB, SLC11A2, CLN3, ATP6AP1, LGMN, AP3S2, NAGA, CTSA, GGA1, AP4M1, AGA, GAA, GALC, LAMP1, GNPTG, ASAH1, SLC17A5, GNS, TCIRG1, CTSH, DNASE2, CD63, CTSF, LAPTM4A, MFSD8, CTSD, AP1M2, ARSG, AP1G1, ATP6V0B, MAN2B1, CLN5, GALNS, LIPA, LAMP3, GLA, SORT1, AP3M1, NPC1, AP3D1, IDS, GGA3, NAGPA, CD68, ACP2, PSAP, MANBA, HEXB, GBA, CTSC, GLB1, ABCA2, CTSS, LAMP2, AP3B1",1.02872415126189,0.104025267640935,FALSE +"H2126","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.26325,0.768,0.813,4631,1,"CACNB2, CACNG1, CACNA1I, CD14, MAP3K4, HSPA1L, PLA2G6, ARRB1, DUSP16, NR4A1, RPS6KA2, TGFBR1, TRAF2, CACNA1D, FGF12, MAP3K8, PLA2G12A, RPS6KA6, FGF19, DUSP8, ARRB2, MKNK1, IKBKB, RELA, MAPK8IP2, PLA2G10, GADD45B, DUSP4, SOS2, ATF4, MAP3K5, FGF11, PDGFB, CACNG6, PLA2G2D, RASGRP3, MAPK13, AKT1, TAOK1, CACNA1A, RPS6KA5, MAP4K3, HSPA1A, MAP2K7, TAB1, PLA2G2C, FGFR3, MAP3K11, MAPK3, HSPA1B, STK3, MKNK2, HSPA2, TAOK3, IL1R1, IKBKG, PLA2G4A, DUSP1, MAPKAPK2, SOS1, RRAS, PRKCG, MAPK1, TNFRSF1A, CACNG8, NLK, CACNG4, CACNA1F, PLA2G4B, GADD45G",0.0899094544059319,0,FALSE +"H2126","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.31047,0.919,0.586,1738,1,"INS, BHLHA15, FOXA3",0.232102383981909,0,FALSE +"H2126","Input","KEGG_MELANOGENESIS",0.32653,0.956,0.514,1246,1,"WNT3A, FZD10, ADCY5, MC1R, ADCY4, WNT4, CREB3L4, CALML6, WNT7B, WNT11",0.289036881004724,0,FALSE +"H2126","Input","KEGG_MELANOMA",-0.3336,-1.16,0.272,15187,0.609,"PIK3CD, FGF18, MAP2K1, EGF, PDGFRA, FGFR1, FGF5, PDGFRB, FGF13, CDKN1A, FGF1, PIK3R1, RAF1, E2F2, FGF22, E2F3, TP53, CDK6, CDKN2A, FGF2, BAD, HRAS, NRAS, PDGFC, AKT3, CDK4",0.565431095965801,0.215382707367125,FALSE +"H2126","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.41418,1.21,0.193,4313,0.847,"GSTA3, ALDH3B2, GSTK1, ALDH3B1, CYP1B1, GSTM5, GSTZ1, GSTA4, GSTO2, GSTM3, MGST1, ALDH1A3, AKR1C2, MGST2, DHDH, CYP2F1, CYP3A43",0.714442690992226,0.0721165896692931,FALSE +"H2126","Input","KEGG_MISMATCH_REPAIR",-0.37099,-1.32,0.15,14311,0.719,"RPA1, POLD2, RFC3, MSH6, MLH1, PCNA, RPA2, RFC1, RPA3, RFC5, RFC4, RFC2",0.823908740944319,0.143271109617117,FALSE +"H2126","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.43345,1.27,0.149,4516,0.713,"INS, CAB39, RPS6KA2, RICTOR, PRKAA2, RPS6KA6, TSC1, PIK3R3, CAB39L, AKT1, RPTOR, MAPK3, VEGFC, PRKAA1, ULK3, VEGFA, MTOR, EIF4B, MAPK1, VEGFD, ULK1",0.826813731587726,0.146910470148134,FALSE +"H2126","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.14128,-0.486,1,12416,0.998,"IFNA13, RAET1G, HCST, CHP2, PLCG1, ICAM1, IFNA21, PPP3CB, IFNGR1, PRKCB, PRF1, NFAT5, IFNA8, PPP3CC, PIK3CG, TNFRSF10C, IFNA1, CD247, TNF, IFNA5, CASP3, IFNB1, GZMB, PPP3R2, LCK, NFATC1, RAC1, PIK3CD, MAP2K1, ULBP1, SHC4, RAET1L, PRKCA, CSF2, SHC3, PPP3R1, ICAM2, PIK3R1, RAF1, TNFRSF10B, NFATC2, SHC2, FAS, ULBP2, ULBP3, HRAS, MICB, NRAS, FYN",0,0.000869458712628891,FALSE +"H2126","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.34377,1.01,0.418,2843,1,"VIPR2, BDKRB2, GHSR, GALR3, P2RY6, CGA, MLNR, BDKRB1, MC1R, SSTR1, F2RL3, P2RX4, GRIN2D, ADORA1, GRIN1, ADRA1D, TRPV1, PTAFR, S1PR4, GABRR2, P2RX2, GABRA3, GABRB3, P2RY2, PLG, GLP2R, DRD4, GH2, LTB4R2, OPRL1, TACR3, LTB4R, TRHR, GRM3",0.378823718224965,0,FALSE +"H2126","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.20862,-0.725,0.872,14936,0.952,"NTRK2, NTRK3, RAC1, IRAK3, PIK3CD, FOXO3, MAPK14, MAP2K1, SHC4, YWHAG, KIDINS220, MAPK7, NTF3, SHC3, GSK3B, NGF, NGFR, RPS6KA4, YWHAE, NFKBIE, CSK, MAPK10, TP73, PIK3R1, RAF1, IRS1, SHC2, CAMK4, CDC42, RHOA, TP53, BDNF, BCL2, JUN, YWHAQ, SH2B3, BAD, HRAS, CALM2, NRAS, AKT3, ARHGDIA, MAP3K3",0.0594835150674328,0.0213630516155257,FALSE +"H2126","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.38503,1.13,0.276,2820,0.931,"CD38, NADK, NADSYN1, NT5C2, NMRK1, NAMPT, NMNAT1",0.559090917934782,0.0310503190186574,FALSE +"H2126","Input","KEGG_NITROGEN_METABOLISM",0.42711,1.25,0.149,1139,0.756,"HAL, GLUL, CTH",0.826813731587726,0.121478204498793,FALSE +"H2126","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.25334,0.746,0.859,6235,1,"NOD2, TAB3, XIAP, IKBKB, RELA, MAPK13, BIRC3, TAB1, MAPK3, CXCL2, IKBKG, CARD8, BIRC2, MAPK1, MAPK11, CCL5, NFKBIB, NFKBIA, CASP8, ERBIN, CASP1, MAPK12, NLRP1",0.0660068361687577,0,FALSE +"H2126","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.41668,-1.51,0.0611,17589,0.726,"PRKDC, XRCC5, XRCC4, FEN1, NHEJ1",1.21395878975745,0.139063379299906,FALSE +"H2126","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.24966,-0.893,0.56,17114,0.777,"PIK3R1, RAF1, E2F2, E2F3, TP53, CDK6, CDKN2A, BAD, HRAS, NRAS, AKT3, CDK4",0.2518119729938,0.109578981199086,FALSE +"H2126","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.23814,0.693,0.903,4437,1,"NUMB, MAML3, APH1A, RFNG, NOTCH3, PSEN1, DTX1, KAT2A, EP300, DVL1, CTBP1, PSENEN, DTX3",0.0443122496864942,0,FALSE +"H2126","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.32406,-1.15,0.239,16205,0.566,"POLE3, PCNA, RPA2, POLE, RFC1, GTF2H1, RPA3, RFC5, ERCC8, CCNH, GTF2H3, RFC4, RFC2",0.621602099051862,0.247183568811729,FALSE +"H2126","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.57278,1.7,0.0194,4082,0.44,"MGAT4A, DPAGT1, MAN2A2, ST6GAL1, MOGS, RPN2, ALG2, MGAT5B, ALG13, STT3A, MAN1B1, B4GALT1, DPM2, ALG6, ALG8, ALG3, DOLPP1, ALG12, ALG10B, ALG11, RPN1, DDOST, ALG5, B4GALT2, DPM3",1.71219827006977,0.356547323513813,FALSE +"H2126","Input","KEGG_OLFACTORY_TRANSDUCTION",0.26721,0.794,0.757,2307,1,"OR1I1, OR10H2, OR6Q1, OR1F1, OR8B8, OR2A14, OR52B4, GUCA1B, OR6B1, OR10AD1, CALML6, OR52K1, OR2A12, GUCY2D, ARRB2, CNGB1, PRKG2, OR10A3, CAMK2G, OR11H1, OR2A2",0.120904120499927,0,FALSE +"H2126","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.3714,-1.36,0.137,17549,0.72,"SHMT2, TYMS, MTR, DHFR",0.863279432843593,0.142667503568732,FALSE +"H2126","Input","KEGG_OOCYTE_MEIOSIS",0.22124,0.652,0.92,2630,1,"ADCY5, ADCY4, SMC1B, INS, CALML6, ANAPC2, ITPR1, RPS6KA2, RPS6KA6, SLK, CDC16, CAMK2G, ADCY6, IGF1R, STAG3, ANAPC5",0.0362121726544447,0,FALSE +"H2126","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.65357,1.91,0.00462,5781,0.585,"FUCA1, MAN2C1, AGA, MAN2B2, ENGASE, MAN2B1, MANBA, HEXB, GBA, GLB1, NEU3",2.33535802444387,0.23284413391782,FALSE +"H2126","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.28498,-1.01,0.398,15908,0.631,"COX7C, ATP5MF, NDUFB3, NDUFA11, SDHC, NDUFA8, COX6B2, UQCRQ, NDUFA2, ATP6V1G2, NDUFB8, ATP6V0A2, ATP6V0D1, ATP5F1C, NDUFA9, NDUFAB1, PPA1, SDHB, COX4I1, UQCRC1, NDUFB5, NDUFA1, ATP6V1A, ATP6V0E1, ATP5MC3, ATP5PF, ATP6V1B2, NDUFS3, COX8A, ATP5PO, NDUFS4, NDUFB6, ATP5F1A, ATP6V1H",0.400116927926312,0.199970640755866,FALSE +"H2126","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.44008,1.29,0.128,3870,0.82,"GCNT3, GALNT6, GALNT12, B3GNT6, ST3GAL1, ST6GALNAC1, GALNT3, GALNT14, GALNT4, C1GALT1C1, C1GALT1, GALNT7, GALNT10",0.892790030352132,0.0861861476162833,FALSE +"H2126","Input","KEGG_P53_SIGNALING_PATHWAY",-0.35516,-1.29,0.138,15946,0.713,"CCND2, COP1, PMAIP1, RRM2, THBS1, PPM1D, CCNE2, CDKN1A, SESN1, TP73, TNFRSF10B, SERPINE1, FAS, SESN3, TP53, CDK6, STEAP3, CDKN2A, GADD45A, CCNB2, SESN2, CDK1, BBC3, CDK4, CCNG1, CCNB1",0.860120913598763,0.146910470148134,FALSE +"H2126","Input","KEGG_PANCREATIC_CANCER",0.23745,0.695,0.899,4562,1,"CASP9, JAK1, PLD1, TGFBR1, STAT3, IKBKB, RELA, ERBB2, PIK3R3, AKT1, MAPK3, VEGFC, SMAD2, IKBKG, VEGFA, RALBP1, MAPK1, VEGFD, RALB",0.0462403082667712,0,FALSE +"H2126","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.3343,0.987,0.454,5018,1,"PPCS, BCAT2, COASY, PPCDC, ENPP1, PANK2",0.342944147142896,0,FALSE +"H2126","Input","KEGG_PARKINSONS_DISEASE",-0.20922,-0.756,0.853,15759,0.921,"UBE2J2, NDUFB10, COX7C, HTRA2, NDUFB3, SDHC, NDUFA8, COX6B2, UQCRQ, NDUFA2, VDAC2, NDUFB8, ATP5F1C, NDUFA9, NDUFAB1, SDHB, COX4I1, UQCRC1, NDUFB5, NDUFA1, ATP5MC3, ATP5PF, NDUFS3, COX8A, ATP5PO, NDUFS4, NDUFB6, ATP5F1A",0.069050968832477,0.0357403698031511,FALSE +"H2126","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.4175,-1.47,0.089,16563,0.557,"ARHGEF2, TLR4, TUBB4A, LY96, TUBB4B, ARPC5L, NCL, CDC42, RHOA, TUBA1B, YWHAQ, TUBB2B, TUBA1A, ACTG1, ARPC4, TUBB, ARPC2, TUBB6, ACTB, FYN, TUBB2A",1.05060999335509,0.254144804826271,FALSE +"H2126","Input","KEGG_PATHWAYS_IN_CANCER",0.1848,0.546,0.992,4372,0.996,"WNT3A, FZD10, CASP9, ARNT2, JAK1, WNT4, PLD1, TRAF4, EPAS1, WNT7B, TGFBR1, TRAF2, STAT3, PIAS3, FGF12, WNT11, FGF19, CBLC, XIAP, IKBKB, EGLN2, RELA, ARNT, ERBB2, RXRA, SOS2, IGF1R, FGF11, PDGFB, PLCG2, PIK3R3, CDH1, ITGA2B, BAX, JUP, LAMA3, AKT1, BIRC3, LAMA5, FOXO1, FGFR3, KITLG, MAPK3, STAT5B, VEGFC, RASSF5, EP300, ITGB1, WNT9A, SMAD2, IKBKG, DVL1, CTBP1, SOS1, PRKCG, VEGFA, MTOR, RALBP1, BIRC2, BID, MAPK1, VEGFD",0.00348832784582135,0.00174066157630127,FALSE +"H2126","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.32989,0.967,0.477,6463,1,"GUSB, UGDH, DHDH, CRYL1, UGP2, DCXR, RPEL1",0.321481620959886,0,FALSE +"H2126","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.39083,1.17,0.218,5330,0.919,"G6PD, FBP1, PRPS1, TKTL1, H6PD, PGM1, PRPS1L1, PRPS2, TKT, PGLS, PGM2, PGD, RBKS",0.661543506395395,0.0366844886138887,FALSE +"H2126","Input","KEGG_PEROXISOME",0.39474,1.16,0.246,4935,0.933,"AGXT, PEX11A, GSTK1, ECH1, PEX1, ABCD1, ACSL1, SLC27A2, ACSL3, SCP2, PXMP4, ACOX3, PEX11G, AMACR, PEX12, PEX2, CROT, PEX11B, PEX13, ABCD4, EPHX2, HMGCL, IDH2, ACAA1, PEX7, XDH, PMVK, MPV17, NUDT19, MLYCD, CRAT, IDH1, PEX26, SLC25A17",0.609064892896621,0.0301183562535,FALSE +"H2126","Input","KEGG_PHENYLALANINE_METABOLISM",0.55039,1.62,0.0311,4471,0.439,"ALDH3B2, ALDH3B1, AOC2, TAT, AOC3, ALDH1A3, NAA80, MAOA",1.50723961097316,0.357535479757879,FALSE +"H2126","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.27493,0.798,0.758,4316,1,"OCRL, CALML6, ITPR1, CDS1, INPP4A, PIP4K2C, PIP5K1B, ITPK1, PLCG2, PIK3R3, PI4KB, DGKE, INPP5B, INPPL1, INPP5K, PRKCG, IMPA2, PLCB1, DGKQ",0.120330794367946,0,FALSE +"H2126","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.27303,0.805,0.756,5228,1,"GUSB, HMBS, CP, COX15, BLVRB, ALAD, BLVRA, PPOX",0.121478204498793,0,FALSE +"H2126","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.37557,1.13,0.267,1877,0.931,"PLIN1, CYP4A22, CPT1B, ANGPTL4, ACADM, ACSL1, CPT2, SLC27A2, PPARA, ACSL3, SCP2, ACOX3, RXRA",0.573488738635425,0.0310503190186574,FALSE +"H2126","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.26912,0.799,0.788,2706,1,"SCP2, AMACR, SLC27A5",0.103473782510445,0,FALSE +"H2126","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.40324,1.19,0.196,3895,0.87,"BLNK, CD4, JAK3, CD40, ADA, CD19, IKBKG",0.707743928643524,0.0604807473813815,FALSE +"H2126","Input","KEGG_PRION_DISEASES",-0.36092,-1.27,0.19,15924,0.629,"SOD1, IL1A, NCAM2, IL1B, ELK1, NOTCH1, NCAM1, PRKACA, C5, EGR1, STIP1, FYN",0.721246399047171,0.201349354554731,FALSE +"H2126","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28673,-1.03,0.322,16429,0.688,"MAD2L2, CCNA1, HSP90AA1, MAPK10, ADCY1, CDC25C, PIK3R1, RAF1, PRKACA, ANAPC13, CPEB1, PDE3B, PKMYT1, MAD2L1, BUB1, GNAI1, CCNB2, PLK1, CDK1, CCNA2, CDC25A, HSP90AB1, AKT3, ADCY7, GNAI2, CCNB1",0.492144128304169,0.162411561764489,FALSE +"H2126","Input","KEGG_PROPANOATE_METABOLISM",0.37599,1.09,0.32,5481,0.917,"MCEE, LDHC, ACADM, ALDH6A1, ACACB, SUCLG2, ACSS2, ALDH2, ACACA, ALDH3A2, PCCB, MLYCD, LDHA, LDHAL6B",0.494850021680094,0.0376306643299789,FALSE +"H2126","Input","KEGG_PROSTATE_CANCER",0.22319,0.655,0.932,4356,1,"CASP9, INS, CREB3L4, IKBKB, RELA, ERBB2, CREB3L2, SOS2, ATF4, IGF1R, PDGFB, PIK3R3, AKT1, FOXO1, MAPK3, CREB1, EP300, IKBKG, SOS1, MTOR, SRD5A2, MAPK1",0.0305840876460186,0,FALSE +"H2126","Input","KEGG_PROTEASOME",-0.33383,-1.18,0.221,14960,0.688,"PSMB6, PSMB11, PSMD2, PSMC5, PSMD8, PSMD13, PSMA4, PSMB2, PSMD1, PSMD14, PSMA1, PSMB1, PSMC3, PSMA2, PSMB7, PSMD6",0.655607726314889,0.162411561764489,FALSE +"H2126","Input","KEGG_PROTEIN_EXPORT",0.47612,1.4,0.0774,6187,0.738,"SRPRA, SRP54, SPCS2, IMMP1L, SEC61A1, OXA1L, SEC62, SPCS3, SPCS1, SRP72, HSPA5, SRPRB, SRP68, SEC61B, IMMP2L",1.11125903931711,0.131943638176958,FALSE +"H2126","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.28306,-1.01,0.378,15771,0.631,"PCK2, ATP1A3, SLC38A3, MDH1, CA2, ATP1A1, GLS",0.422508200162775,0.199970640755866,FALSE +"H2126","Input","KEGG_PURINE_METABOLISM",0.27774,0.822,0.729,4157,1,"ADCY5, ENTPD8, PDE4D, ADCY4, CANT1, PRUNE1, PDE8B, PDE4A, GUCY2D, PRPS1, POLR2J2, NT5C2, ENTPD2, ENTPD5, ADCY6, ENTPD6, POLR3F, POLR3GL, NME3, AK7, GMPR2, NUDT9, GDA, PRPS1L1, ADA, POLD4, PDE10A, POLR2J3, PAPSS2, PDE5A, PRPS2, ITPA, ENPP1, XDH, AMPD3, POLR2K",0.137272471682025,0,FALSE +"H2126","Input","KEGG_PYRIMIDINE_METABOLISM",0.18309,0.529,0.995,4292,0.992,"ENTPD8, TYMP, CANT1, CMPK1, POLR2J2, NT5C2, ENTPD5, ENTPD6, POLR3F, POLR3GL, NME3, TXNRD1, POLD4, POLR2J3, ITPA, CAD, POLR2K, CTPS2, CDA",0.00217691925427455,0.00348832784582135,FALSE +"H2126","Input","KEGG_PYRUVATE_METABOLISM",0.28879,0.851,0.702,5481,1,"LDHC, ACACB, LDHD, ACSS2, ALDH2, ACACA, PC, ALDH3A2, HAGH, DLAT, MDH2, PDHA1, ME1, LDHA, GRHPR, DLD, LDHAL6B",0.153662887870195,0,FALSE +"H2126","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.20719,0.609,0.957,4066,1,"BDKRB2, BDKRB1, CD14, ITGB2, INS, VAV1, ARHGEF4, FGF12, FGF19, SLC9A1, ITGB6, SSH3, RDX, PIP4K2C, PIP5K1B, WASL, ITGB5, SOS2, ITGA1, MYH14, PAK4, PAK6, ARPC1A, ITGAL, FGF11, PDGFB, PIK3R3, ITGA2B, ARHGAP35, IQGAP1, ARPC1B, VAV2, FGFR3, ARHGEF1, MAPK3, ARHGEF12, ARHGEF7, ROCK1, ITGB1, FGD3, SOS1, TIAM1, RRAS",0.0190880622231565,0,FALSE +"H2126","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.24372,0.72,0.874,5460,1,"INS, PRKAA2, ATG4C, PRKAA1, ULK3, ULK1, GABARAPL1, ULK2, BECN2",0.058488567365597,0,FALSE +"H2126","Input","KEGG_RENAL_CELL_CARCINOMA",0.25122,0.735,0.87,4372,1,"ARNT2, GAB1, EPAS1, EGLN2, ARNT, SOS2, PAK4, PAK6, PDGFB, PIK3R3, AKT1, MAPK3, VEGFC, EP300, SOS1, VEGFA, MAPK1, VEGFD",0.0604807473813815,0,FALSE +"H2126","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.32455,0.947,0.526,2328,1,"CTSA, ACE2, NLN",0.279014255846261,0,FALSE +"H2126","Input","KEGG_RETINOL_METABOLISM",0.4369,1.27,0.126,4313,0.713,"CYP4A22, CYP2A7, RDH10, DGAT1, CYP2A6, RDH16, CYP26B1, PNPLA4, DHRS3, ALDH1A2, DGAT2, RDH11, CYP26C1, CYP3A43",0.899629454882437,0.146910470148134,FALSE +"H2126","Input","KEGG_RIBOFLAVIN_METABOLISM",0.55933,1.63,0.0197,5192,0.473,"RFK, ACP6, PHPT1, ACP1, FLAD1, ENPP1, ACP2",1.70553377383841,0.325138859262188,FALSE +"H2126","Input","KEGG_RIBOSOME",-0.24649,-0.866,0.597,17221,0.792,"RPS12, RPL29, RPS26, RPL22L1, FAU, RPL24, RPL35, RPL5, RPL15, RPL35A, RPL26L1, RPL32, RPL14, RPSA, RPS20, RPL17",0.224025668870631,0.101274818410506,FALSE +"H2126","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.22133,0.648,0.942,6603,1,"IRF3, TRAF2, NLRX1, DHX58, IKBKB, RELA, TKFC, TRADD, MAPK13, TBK1, IKBKG, MAVS, TRAF3, OTUD5, MAPK11, NFKBIB, FADD, NFKBIA, DDX3X, CASP8, IFIH1, TRIM25, MAPK12, RIPK1, CASP10, TBKBP1",0.0259490972071227,0,FALSE +"H2126","Input","KEGG_RNA_DEGRADATION",-0.3358,-1.17,0.242,17314,0.625,"EXOSC9, EXOSC7, LSM1, CNOT10, PATL1, EXOSC3, HSPD1, DCP2, LSM6, LSM5, LSM3, ENO2, DCP1B",0.616184634019569,0.204119982655925,FALSE +"H2126","Input","KEGG_RNA_POLYMERASE",-0.19769,-0.715,0.858,17487,0.92,"POLR1E, POLR2D, POLR2E",0.0665127121512946,0.0362121726544447,FALSE +"H2126","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.33451,0.98,0.484,3468,1,"BUD23, CTH, AHCYL1, METTL2B, HEMK1, AHCYL2, PAPSS2",0.315154638355588,0,FALSE +"H2126","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.21519,0.626,0.96,3187,1,"CASP9, TRAF4, TRAF2, PIAS3, XIAP, IKBKB, RELA, RXRA, PIK3R3, APAF1, ITGA2B, LAMA3, AKT1, BIRC3, LAMA5",0.0177287669604316,0,FALSE +"H2126","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.33582,0.99,0.463,4565,1,"GOSR2, BET1, BET1L, STX19, GOSR1, STX17, VAMP7, STX16, SNAP23, VAMP8, YKT6, VTI1B, SEC22B, VAMP4, STX1A",0.334419008982047,0,FALSE +"H2126","Input","KEGG_SPHINGOLIPID_METABOLISM",0.28133,0.823,0.739,2479,1,"SGPP1, ARSA, DEGS2, PLPP3, GALC, ASAH1, ENPP7",0.131355561605174,0,FALSE +"H2126","Input","KEGG_SPLICEOSOME",-0.31632,-1.17,0.27,16081,0.625,"PRPF18, SNRPD2, SF3B6, RBMX, CDC5L, SRSF3, MAGOHB, HNRNPU, SF3A2, LSM2, SNRPD1, HSPA8, SRSF1, HSPA6, HNRNPC, HNRNPA1, PPIL1, SYF2, SF3B3, ALYREF, HNRNPM, SRSF10, SNRPB, HNRNPK, U2SURP, PQBP1, HNRNPA1L2, TRA2B, SMNDC1, SF3B5, HNRNPA3, ISY1, SNRPE, SNRPC, U2AF1, LSM6, BCAS2, PRPF19, LSM5, LSM3, TXNL4A",0.568636235841013,0.204119982655925,FALSE +"H2126","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.3691,1.1,0.31,5886,0.917,"GYS1, HK2, GUSB, UGDH, GAA, PGM1, PYGL, ENPP1, MGAM, PGM2, UGP2, G6PC2, PYGB",0.508638306165727,0.0376306643299789,FALSE +"H2126","Input","KEGG_STEROID_BIOSYNTHESIS",0.45101,1.32,0.115,5705,0.742,"MSMO1, CYP27B1, LIPA, NSDHL, DHCR7, DHCR24, SC5D, TM7SF2",0.939302159646388,0.129596094720973,FALSE +"H2126","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38017,1.11,0.301,4720,0.92,"SRD5A3, SULT2B1, CYP1B1, CYP11B1, HSD17B8, SRD5A1, COMT, AKR1C2, SRD5A2, CYP3A43, HSD17B2",0.521433504406157,0.0362121726544447,FALSE +"H2126","Input","KEGG_SULFUR_METABOLISM",0.56845,1.7,0.0149,4359,0.44,"SULT2B1, SULT1A3, SUOX, SULT1A4, PAPSS2, CHST11, SULT1A2, CHST12",1.82681373158773,0.356547323513813,FALSE +"H2126","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.31191,-1.1,0.263,11837,0.614,"CTSG, FCGR2B, CD80, C9, IL10, C6, C7, CD86, FCGR2C, TNF, GRIN2A, SNRPD3, GRIN2B, ELANE, ACTN2, FCGR2A, SNRPD1, SSB, C5, C1R, SNRPB, ACTN1",0.580044251510242,0.211831628858832,FALSE +"H2126","Input","KEGG_TASTE_TRANSDUCTION",0.43734,1.28,0.13,3465,0.789,"TAS2R3, TAS1R3, TAS2R4, ADCY4, SCNN1A, TAS2R38, ADCY6, TAS2R10, TAS2R5, TAS2R39, CACNA1A, TAS2R41",0.886056647693163,0.10292299679058,FALSE +"H2126","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.28006,0.83,0.73,1945,1,"CSAD",0.136677139879544,0,FALSE +"H2126","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.31235,0.919,0.592,4183,1,"DHDDS, MVD, PDSS2, PMVK",0.22767829327708,0,FALSE +"H2126","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.22574,0.658,0.926,3917,1,"INHBB, TGFBR1, BMP6, SP1, BMP7, ID1, THBS3, BMP8B, SMURF1, LTBP1, ID3, RBL2, BMP8A, MAPK3, EP300, ROCK1, PPP2R1B, SMAD2, E2F5",0.0333890133180656,0,FALSE +"H2126","Input","KEGG_THYROID_CANCER",-0.32728,-1.11,0.289,17604,0.622,"PAX8, NCOA4, TP53, TCF7, HRAS, NRAS",0.539102157243452,0.206209615309181,FALSE +"H2126","Input","KEGG_TIGHT_JUNCTION",-0.22937,-0.85,0.675,15576,0.785,"CLDN11, CASK, CLDN22, JAM2, PARD3, PRKCA, MYLPF, PPP2R2A, MYL5, RAB3B, CSNK2A2, MYH9, PPP2R2B, MYH15, RRAS2, MRAS, LLGL1, MAGI2, JAM3, CDC42, TJAP1, RHOA, MYL9, GNAI1, ACTN1, ACTG1, HRAS, PARD6G, NRAS, MPDZ, CSNK2B, AKT3, CDK4, GNAI2, PPP2R2D, ACTB, EPB41L2",0.170696227168975,0.105130343254747,FALSE +"H2126","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.26952,0.79,0.759,3895,1,"LBP, CD14, TIRAP, IRAK4, IRF3, MAP3K8, IKBKB, RELA, PIK3R3, CD40, MAPK13, AKT1, MAP2K7, TAB1, TBK1, MAPK3, TLR3, MYD88, IKBKG",0.11975822410452,0,FALSE +"H2126","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.28315,-1.01,0.419,16065,0.631,"TPH1, WARS2, AOX1, KYNU, OGDHL, CYP1A1, ALDH1B1, ECHS1, ACAT1, ALDH9A1, AADAT",0.377785977033705,0.199970640755866,FALSE +"H2126","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.37967,1.13,0.254,4356,0.931,"IRS2, INS, HK2, CACNA1D, IKBKB, SOCS2, PIK3R3, CACNA1A, MAPK3, SOCS4, PRKCD, MTOR, MAPK1",0.595166283380062,0.0310503190186574,FALSE +"H2126","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.46804,1.37,0.0908,1507,0.755,"CPE, INS, ICA1, PTPRN2",1.04191415147891,0.122053048370812,FALSE +"H2126","Input","KEGG_TYROSINE_METABOLISM",0.48019,1.39,0.0829,2664,0.727,"TH, ALDH3B2, ALDH3B1, BUD23, HGD, AOC2, TAT, GSTZ1, METTL2B, AOC3, COMT, HEMK1",1.08144546944973,0.138465589140962,FALSE +"H2126","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.17101,-0.629,0.985,15187,0.987,"PIK3CD, MAP3K14, MAPK14, MAP2K1, CD8A, MAP3K7, CARD11, CSF2, RASGRP1, PAK3, GSK3B, PPP3R1, NFKBIE, DLG1, PIK3R1, RAF1, NFATC2, CDC42, RHOA, JUN, HRAS, NRAS, BCL10, AKT3, MALT1, CDK4, FYN",0.00656376950238827,0.00568284733036327,FALSE +"H2126","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.22621,0.655,0.938,4294,1,"RHOBTB2, PPIL2, CUL7, ANAPC2, CUL5, PIAS3, CBLC, XIAP, FBXW8, UBOX5, UBE4A, CDC16, UBE2Q1, SMURF1, SYVN1, HERC1, UBE2Q2, FBXO4, UBE2H, NHLRC1, UBE2M, ANAPC5, DET1, UBE2G2, WWP1, BIRC3, MID1, HUWE1, ITCH, ANAPC11, BTRC, DDB2, UBE2G1, BIRC2",0.0277971616209356,0,FALSE +"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.3008,0.894,0.636,2403,1,"BCAT2, VARS2",0.196542884351586,0,FALSE +"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.30329,0.887,0.624,4339,1,"MCEE, ACAD8, ACADM, ALDH6A1, BCAT2, BCKDHA, AUH, OXCT2, ACADS, HMGCL, ALDH2, ALDH3A2, ACAA1, HADHB, PCCB",0.204815410317576,0,FALSE +"H2126","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.28432,0.834,0.73,4652,1,"ADCY5, CYP4A22, ADCY4, PLA2G6, CALML6, ITPR1, ADRA1D, CACNA1D, PLA2G12A, PPP1R14A, PLA2G10, ADCY6, PRKCH, PLA2G2D, PLA2G2C, ARHGEF1, MAPK3, PRKCD, ARHGEF12, ROCK1, PLA2G4A, PRKCG, PLCB1, KCNMB3, MAPK1, CACNA1F, GNAQ, PLA2G4B, NPR2",0.136677139879544,0,FALSE +"H2126","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.25984,0.757,0.834,3924,1,"AQP3, CREB3L4, RAB11B, NSF, CREB3L2, ADCY6, DYNC1LI2, RAB5B, CREB1, DYNC2LI1",0.0788339493622613,0,FALSE +"H2126","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.25173,0.739,0.842,4798,1,"CASP9, PLA2G6, PLA2G12A, PLA2G10, PLCG2, PLA2G2D, PIK3R3, MAPK13, AKT1, PLA2G2C, MAPK3, PLA2G4A, MAPKAPK2, PRKCG, VEGFA, MAPK1, PLA2G4B, MAPK11, PXN",0.0746879085003505,0,FALSE +"H2126","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.28025,0.83,0.721,4398,1,"ATP6V1B1, ATP6V0A4, ATP6AP1, KDELR3, PDIA4, ERO1A, TCIRG1, PLCG2, KDELR1, KDELR2, ATP6V0B, ATP6V0E2, PRKCG, SEC61A1, ATP6V1G1, ARF1, TJP2",0.142064735280571,0,FALSE +"H2126","Input","KEGG_VIRAL_MYOCARDITIS",0.22878,0.673,0.916,2655,1,"CASP9, ITGB2, CD55, MYH14, ITGAL, CD40",0.0381045263321496,0,FALSE +"H2126","Input","KEGG_WNT_SIGNALING_PATHWAY",0.2155,0.622,0.954,1426,1,"WNT3A, FZD10, CSNK1E, FRAT1, WNT4, WNT7B, WNT11, LRP5, FRAT2",0.0204516252959049,0,FALSE +"H520","Input","KEGG_ABC_TRANSPORTERS",0.22153,0.618,0.959,3230,1,"ABCC5, ABCB7, ABCA7, ABCA3, ABCC2, ABCD4, ABCC8",0.0181813928293364,0,FALSE +"H520","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.46206,1.28,0.134,3881,0.641,"ZBTB16, EIF4EBP1, TCF7, RUNX1, MAP2K1, MAP2K2, LEF1, TCF7L2, PIK3CA, BRAF, RAF1, MTOR, SOS1, PIK3CB, RPS6KB2, SOS2, PIK3R2, AKT2",0.872895201635192,0.193141970481183,FALSE +"H520","Input","KEGG_ADHERENS_JUNCTION",-0.31888,-1.12,0.276,17653,0.785,"MET, PTPRB, SNAI2, PTPN1, SNAI1, RAC2, VCL, NECTIN2, PTPRM, IQGAP1, PTPRJ, CDC42, ACTB, ERBB2, RHOA, EGFR, INSR, TGFBR2, IGF1R, BAIAP2",0.559090917934782,0.105130343254747,FALSE +"H520","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.26156,0.724,0.864,4366,1,"ADIPOQ, PRKCQ, PCK2, PTPN11, STK11, MAPK9, MTOR, CAMKK2, PRKAG1, NFKBIB, SLC2A1, ADIPOR1, AKT2, PRKAB2, ACACB",0.0634862575211067,0,FALSE +"H520","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.41546,1.17,0.228,3710,0.773,"GPT2, GLUD2, GOT2, ASNS, CAD, GAD1, GLUL, PPAT, ASS1",0.642065152999546,0.111820506081675,FALSE +"H520","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.26264,0.732,0.875,2852,1,"IGF1, KCNJ1, PIK3CA, PDPK1, SCNN1A, PIK3CB",0.0579919469776868,0,FALSE +"H520","Input","KEGG_ALLOGRAFT_REJECTION",-0.31593,-1.1,0.287,17766,0.757,"CD40, IL12A, FAS",0.542118103266008,0.120904120499927,FALSE +"H520","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.30686,0.863,0.68,3580,1,"PLA2G12A, FADS2, PLA2G3",0.167491087293764,0,FALSE +"H520","Input","KEGG_ALZHEIMERS_DISEASE",0.3064,0.856,0.697,5666,0.999,"NDUFS5, ITPR1, NDUFS7, ADAM10, CASP7, ATP2A1, NDUFB10, COX4I1, UQCR11, SDHB, NDUFA2, NDUFA10, ATP5F1D, NAE1, LPL, NDUFA9, COX7C, ERN1, COX7A2L, NDUFA7, PPP3R1, ATP5F1C, UQCRQ, CALML5, NDUFA4L2, COX5A, NDUFAB1, GSK3B, NDUFC2, ATP5MC3, NDUFB6, APH1A, PSEN2, MME, CDK5R1, PLCB1, NDUFB7, UQCRC2, NDUFS6, NDUFA4, ATP2A2, NDUFS3, NDUFA1, UQCRHL, NDUFB9, CYC1, CALML6, RYR3, NDUFB1, ADAM17, NDUFC1, PSEN1, UQCRB, MAPK1, ATP5F1A, NDUFV1, NDUFB5, CALML3",0.156767221901991,0.000434511774017692,FALSE +"H520","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.50499,1.41,0.0633,7188,0.564,"WARS2, RARS2, EARS2, SEPSECS, HARS2, FARSB, MARS2, MTFMT, CARS2, LARS2, IARS2, PARS2, FARSA, TARS2",1.19859628998265,0.248720896016658,FALSE +"H520","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.45499,-1.61,0,16174,0.72,"GCK, NPL, RENBP, FPGT, UGDH, UAP1, GMPPA, UXS1, CYB5R1, HEXB, CYB5R3, NAGK, GALK1, CMAS, GALE, NANP, PGM1",Inf,0.142667503568732,FALSE +"H520","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.28112,0.783,0.801,1987,1,"SLC1A2, SOD1, NEFL, DERL1, MAP2K6",0.0963674839157623,0,FALSE +"H520","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.29611,0.825,0.739,1328,1,"IFNA5, NFYC, RFXAP, NFYB, CANX, CREB1",0.131355561605174,0,FALSE +"H520","Input","KEGG_APOPTOSIS",-0.2831,-0.978,0.468,14862,0.725,"BCL2, IRAK4, PPP3R2, TNF, CASP8, PIK3R1, PRKAR2B, PRKAR2A, NFKBIA, TNFRSF10C, IRAK3, AKT3, IKBKB, IL1A, TNFRSF1A, IL1B, NGF, BAX, ENDOD1, BID, BIRC3, TP53, PIK3CD, CASP10, TRADD, TNFRSF10D, CAPN2, FAS, IL1RAP, CAPN1, MAP3K14",0.329754146925876,0.139661993429006,FALSE +"H520","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.17423,-0.62,0.979,13977,0.968,"ALOX15, CYP2C8, PLA2G1B, CYP4A22, CYP4F3, GGT6, GGT7, PTGS1, PTGIS, GGT5, CBR3, PTGDS, ALOX5, PTGES2, PTGS2, CYP2E1, GPX1, PTGES, EPHX2",0.00921730819686218,0.0141246426916063,FALSE +"H520","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.36736,1.04,0.389,3744,0.843,"SMS, GLUD2, ARG2, GOT2, MAOB, PYCR1, CKB, ALDH2, ALDH9A1, PYCR2, SAT1, GLUL, ASS1, ALDH3A2",0.410050398674292,0.0741724253752577,FALSE +"H520","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.23383,-0.792,0.759,14536,0.899,"ITGA7, SGCD, ITGA10, TCF7L1, ACTN1, ITGA1, SGCA, ACTN2, CACNG7, DES, ITGA2, ITGB5, CACNA2D4, ITGA2B, ITGA11, CACNA1C, CACNG6, ACTG1, CACNG4, ITGA4, CACNG8, ITGAV, ITGB8, ITGB6, GJA1, ITGB3, CACNA2D1, ITGA5, LMNA, DAG1, ITGB1, ACTB, ITGA3, CACNB3",0.11975822410452,0.0462403082667712,FALSE +"H520","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.55198,1.54,0.0306,4712,0.683,"UGT2A1, MIOX, ALDH2, ALDH9A1, ALDH3A2, ALDH7A1",1.51427857351842,0.165579296318467,FALSE +"H520","Input","KEGG_ASTHMA",0.64109,1.79,0.00557,55,0.995,"EPX",2.25414480482627,0.00217691925427455,FALSE +"H520","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.62081,1.73,0.00768,438,0.489,"CTLA4, IFNA5, PRF1",2.11463877996849,0.31069114087638,FALSE +"H520","Input","KEGG_AXON_GUIDANCE",-0.26297,-0.872,0.494,17072,0.8,"CDK5, EPHB6, SEMA3E, EFNB3, NFATC2, SLIT2, CFL1, NGEF, MET, SEMA4A, EFNB2, EFNB1, EPHA2, NRP1, NFATC1, EFNA3, SEMA7A, RAC2, ABLIM3, ITGB1, NTN4, CDC42, L1CAM, SEMA3A, EFNA1, EPHB2, EFNA5, RHOA, SEMA4B, PLXNB2, SRGAP1, SEMA3C",0.306273051076353,0.0969100130080564,FALSE +"H520","Input","KEGG_BASAL_CELL_CARCINOMA",0.39497,1.09,0.304,4056,0.91,"DVL3, AXIN2, TCF7, SHH, APC, FZD1, LEF1, WNT11, TCF7L2, FZD3, PTCH2, AXIN1, CTNNB1, FZD10, GSK3B, BMP4, WNT8B",0.517126416391246,0.0409586076789064,FALSE +"H520","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.43897,1.23,0.17,4856,0.712,"GTF2F1, TAF1, GTF2A2, TBP, TAF6L, GTF2A1, GTF2H3, TAF7, TAF2, TAF5, TAF1L, TAF9B, TAF11, GTF2IRD1",0.769551078621726,0.147520006363144,FALSE +"H520","Input","KEGG_BASE_EXCISION_REPAIR",0.33446,0.938,0.547,6120,0.942,"MUTYH, MBD4, POLD3, TDG, LIG3, NEIL1, POLL, NTHL1, POLE, FEN1, POLE4, XRCC1, POLE3, POLD2, OGG1, NEIL3",0.262012673666569,0.0259490972071227,FALSE +"H520","Input","KEGG_BETA_ALANINE_METABOLISM",0.5122,1.43,0.0671,5769,0.666,"SMS, ALDH2, ALDH9A1, CNDP1, HADHA, GAD1, HIBCH, ALDH3A2, ALDH7A1, AOC3, EHHADH, MLYCD, AOC2",1.17327747983101,0.176525770829699,FALSE +"H520","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.26181,0.735,0.854,3576,1,"HACD2, PECR, HADHA, FADS2, HSD17B12, TECR",0.068542129310995,0,FALSE +"H520","Input","KEGG_BLADDER_CANCER",-0.2505,-0.872,0.607,17931,0.8,"CXCL8, PGF, TYMP, VEGFC, DAPK1, CDKN1A, TP53, ERBB2, EGFR",0.216811308924742,0.0969100130080564,FALSE +"H520","Input","KEGG_BUTANOATE_METABOLISM",0.38102,1.06,0.343,5901,0.879,"OXCT2, ALDH2, PDHA1, ALDH9A1, HADH, HADHA, GAD1, L2HGDH, ALDH3A2, AACS, ALDH7A1, EHHADH, BDH1, ACAT1",0.464705879957229,0.0560111249262281,FALSE +"H520","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.24486,0.689,0.904,4278,1,"SYK, MALT1, NFATC3, MAP2K1, MAP2K2, PIK3CA, RAF1, SOS1, PPP3R1, PIK3CB, NFKBIB, GSK3B, SOS2, PIK3R2, AKT2, RAC3, PTPN6",0.0438315695246367,0,FALSE +"H520","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.28608,0.782,0.776,3460,1,"CACNA1E, CHRM3, HTR2C, SLC8A1, PHKB, ADCY7, ITPR1, SLC25A4, MYLK2, CHRNA7, GNAL, ATP2A1, VDAC2, GNA11, PHKA2, LTB4R2, ADRB1, VDAC1, PHKA1, ERBB4, PPP3R1, SLC25A5, PRKX, CACNA1B, ADCY1, PRKACB, PPID, CALML5",0.110138278741812,0,FALSE +"H520","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.16116,0.456,0.999,5367,0.999,"SLC8A1, CACNA2D3, COX4I1, UQCR11, COX7C, COX7A2L, UQCRQ, COX5A, UQCRC2, ATP2A2, UQCRHL, CYC1, ATP1B3, ATP1B1, UQCRB",0.000434511774017692,0.000434511774017692,FALSE +"H520","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.29701,0.831,0.739,1475,1,"CTLA4, SELE, NRXN3, MADCAM1, CNTN1, NRCAM, NLGN3, CADM1",0.131355561605174,0,FALSE +"H520","Input","KEGG_CELL_CYCLE",0.44489,1.24,0.169,5198,0.702,"RAD21, GADD45G, CDC14A, ORC6, CDC23, FZR1, ORC3, STAG2, ORC2, ESPL1, TGFB2, CDC20, CCNB2, CDK1, CHEK1, MCM2, PLK1, CREBBP, BUB1B, CDKN2D, SMAD4, CDC25C, ATM, RBL1, E2F2, MAD2L1, PKMYT1, TTK, ANAPC7, STAG1, BUB3, SKP2, E2F4, ANAPC1, ORC5, ZBTB17, ORC4, CDKN2A, GSK3B, RBL2, E2F1, CDC27, BUB1, MAD2L2, MCM6, RB1, CCNH, SKP1, ATR, CDK6, SMAD2, ANAPC11, CCNA2, EP300, HDAC2, MCM3, CDC14B",0.772113295386326,0.153662887870195,FALSE +"H520","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.20211,0.564,0.975,4667,1,"CXCL14, CCL27, XCL1, ADCY7, CXCR4, GRK6, PAK1, ELMO1, MAP2K1, GNB1, XCL2, PIK3CA, BRAF, RAF1, SOS1, TIAM1, GNG2, PIK3CB, PRKX, WAS, NFKBIB, ADCY1, PRKACB, GSK3B, GSK3A, SOS2, PIK3R2, AKT2, CXCR2, GRK2, GNG7, PTK2, PLCB1, PRKCZ, GNAI1, CRKL, GNB3",0.0109953843014632,0,FALSE +"H520","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.31649,0.893,0.667,5613,0.973,"RUNX1, MAP2K1, MAP2K2, CTBP1, PIK3CA, PTPN11, TGFB2, BRAF, RAF1, CBL, SOS1, SMAD4, E2F2, PIK3CB, CDKN2A, SOS2, PIK3R2, AKT2, E2F1, TGFBR1, RB1, CRKL, CDK6, BCL2L1, HDAC2, MAPK1, CTBP2, CRK, MYC, E2F3",0.175874166083451,0.0118871597316481,FALSE +"H520","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.22889,-0.853,0.705,17633,0.804,"PER1, BHLHE41",0.151810883008601,0.0947439512515487,FALSE +"H520","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.2508,0.697,0.9,5651,1,"PCK2, PDHA1, SDHB, IDH1, FH, DLAT, DLST, SUCLA2, SUCLG1",0.0457574905606751,0,FALSE +"H520","Input","KEGG_COLORECTAL_CANCER",0.36715,1.03,0.424,4149,0.823,"AXIN2, TCF7, APC, MAP2K1, LEF1, TCF7L2, PIK3CA, TGFB2, BRAF, RAF1, MAPK9, SMAD4, AXIN1, PIK3CB, CTNNB1, BIRC5, GSK3B, APPL1, PIK3R2, AKT2, TGFBR1, RAC3",0.372634143407267,0.0846001647877302,FALSE +"H520","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.3245,-1.11,0.272,15340,0.77,"VWF, A2M, C4A, C3AR1, CD55, C1S, C4BPB, SERPING1, CFB, PROS1, THBD, BDKRB1, CFI, SERPINA1, BDKRB2, CFH, F3, C3, PLAT, SERPINE1, F2R, PLAU, TFPI, CD59, PLAUR",0.565431095965801,0.113509274827518,FALSE +"H520","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.4262,1.19,0.218,5408,0.744,"SMS, GOT2, CBS, MAT2A, MAT2B, APIP, DNMT3B, ADI1, DNMT3A, MTAP, AHCY, DNMT1",0.661543506395395,0.128427064454121,FALSE +"H520","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.24216,-0.853,0.646,16314,0.804,"PDGFC, IL18R1, TNFRSF6B, IL1A, CSF2, CCL5, VEGFB, CXCR6, PDGFRB, TNFRSF11A, PDGFA, LEPR, IFNAR2, IL7, TNFSF15, TNFRSF1A, IL1B, CCL20, CSF2RA, CCL26, CD70, CXCL16, CX3CL1, BMP2, CCR10, IL7R, CCL28, IL6, TNFRSF25, INHBA, IL17RA, CXCL3, MET, IFNGR1, CXCL1, CD40, ACVR2A, TGFB3, CXCL2, CXCL8, CTF1, IL12A, TNFSF12, VEGFC, TNFSF13, TNFSF9, ACVR1, IL18, TNFRSF14, IL6R, TNFRSF10D, PLEKHO2, TGFB1, CSF1, OSMR, LIF, FAS, IL6ST, CLCF1, EGFR, IL1RAP, TGFBR2, IL4R, TNFRSF12A",0.189767482004916,0.0947439512515487,FALSE +"H520","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.27384,-0.971,0.452,15432,0.718,"CXCL10, AIM2, POLR3H, NFKBIA, RIPK3, IKBKB, DDX58, CCL5, IL1B, IL6, CASP1, POLR1C, IRF3, TBK1, IL18, POLR3F, IKBKE",0.344861565188618,0.1438755557577,FALSE +"H520","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.29087,-1.05,0.348,15170,0.683,"ITGA1, TNF, SGCA, TNNC1, CACNG7, DES, ITGA2, ITGB5, CACNA2D4, ITGA2B, ITGA11, ADCY4, CACNA1C, CACNG6, ACTG1, CACNG4, ITGA4, CACNG8, ITGAV, ITGB8, ITGB6, GNAS, ITGB3, TNNI3, CACNA2D1, TGFB3, TPM1, ITGA5, LMNA, ADCY9, DAG1, ITGB1, TGFB1, TPM2, ACTB, ITGA3, CACNB3",0.458420756053419,0.165579296318467,FALSE +"H520","Input","KEGG_DNA_REPLICATION",0.48576,1.33,0.0969,6012,0.603,"RFC4, RNASEH1, DNA2, POLA1, POLD3, MCM2, RNASEH2C, MCM6, RNASEH2B, RFC1, POLE, RFC5, RPA4, FEN1, POLE4, PRIM2, MCM3, MCM7, POLE3, POLD2, RNASEH2A, RPA2, RFC3, POLA2",1.01367622294923,0.219682687859849,FALSE +"H520","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.40979,-1.45,0.0833,18696,0.797,"ETV6, EGFR, ETS2, ETS1, SPIRE1",1.07935499859321,0.0985416786038876,FALSE +"H520","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.21311,-0.749,0.855,16067,0.878,"GSTM1, GSTM3, GSTT2, FMO4, CYP2E1, AOX1, GSTM4, MAOA, GSTO1, ALDH3B1, GSTK1, MGST3",0.0680338852718274,0.0565054840938974,FALSE +"H520","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.26675,0.732,0.869,1088,1,"UCK2, UGT2A1, CES1, GMPS",0.0609802235513335,0,FALSE +"H520","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.43593,-1.5,0.0659,15170,0.819,"ITGA1, GP6, RELN, VWF, LAMC3, COL11A1, ITGA2, COL5A1, COL5A3, ITGB5, THBS2, ITGA2B, CD36, COL6A3, ITGA11, COL6A2, SDC3, ITGA4, COL3A1, LAMA1, COL1A2, LAMC2, SDC2, COL5A2, ITGAV, ITGB8, COL4A2, ITGB6, ITGB3, LAMA4, LAMB2, COL6A1, COL1A1, AGRN, LAMA3, ITGA5, TNC, COL4A1, DAG1, LAMA5, ITGB1, LAMB3, SDC4, ITGA3, HSPG2, LAMB1",1.18111458540599,0.0867160982395816,FALSE +"H520","Input","KEGG_ENDOCYTOSIS",-0.20867,-0.761,0.832,17598,0.896,"ADRB2, ARFGAP1, VPS37D, LDLRAP1, MET, FGFR2, STAM, PARD6B, ASAP3, CHMP4B, ARAP2, ACAP1, HSPA1B, ARAP3, DAB2, F2R, SMURF1, CDC42, PLD1, EHD1, RAB31, CLTCL1, EHD2, EGFR, ARAP1, ARRB1, IQSEC2, IGF1R, RAB11FIP5",0.0798766737092761,0.0476919903378748,FALSE +"H520","Input","KEGG_ENDOMETRIAL_CANCER",0.48157,1.34,0.0976,3881,0.625,"CTNNA2, AXIN2, TCF7, APC, MAP2K1, MAP2K2, LEF1, TCF7L2, PIK3CA, PDPK1, BRAF, RAF1, CTNNA1, SOS1, AXIN1, PIK3CB, CTNNB1, GSK3B, SOS2, PIK3R2, AKT2",1.01055018233331,0.204119982655925,FALSE +"H520","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.24316,0.681,0.915,3902,1,"PTPRZ1, ATP6V0B, PAK1, ATP6V0A2, ATP6V1E2, ADAM10, PTPN11, MAPK9, GIT1, ATP6V1G2, ATP6V0C, ATP6V1H, F11R, CXCR2",0.0385789059335517,0,FALSE +"H520","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.30689,0.859,0.684,4593,1,"EIF4EBP1, PAK2, PAK1, MAP2K1, MAP2K7, MAP2K2, NRG3, PIK3CA, BRAF, RAF1, MAPK9, MTOR, CBL, SOS1, ERBB4, PIK3CB, RPS6KB2, NCK1, GSK3B, SOS2, PIK3R2, AKT2, PTK2, CAMK2G, MAP2K4, TGFA, CRKL",0.164943898279884,0,FALSE +"H520","Input","KEGG_ETHER_LIPID_METABOLISM",0.31444,0.874,0.651,3580,0.999,"PLA2G7, CHPT1, PLA2G12A, PAFAH1B2, PAFAH2, PLA2G3",0.186419011431808,0.000434511774017692,FALSE +"H520","Input","KEGG_FATTY_ACID_METABOLISM",0.37333,1.04,0.395,6710,0.843,"ECI1, ACAA2, ALDH2, ALDH9A1, HADH, HADHA, ADH5, ALDH3A2, ALDH7A1, CPT1B, ADH6, ACADSB, EHHADH, CPT1A, ACAT1, ECI2, CPT2, GCDH, ACSL5, ECHS1, ADH1C",0.40340290437354,0.0741724253752577,FALSE +"H520","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.31452,0.896,0.617,4149,0.977,"SYK, MAP2K1, MAP2K7, MAP2K2, PIK3CA, PDPK1, MAP2K6, RAF1, MAPK9, FYN, SOS1, PLA2G12A, PIK3CB, PLA2G3, SOS2, PIK3R2, AKT2, RAC3",0.209714835966758,0.0101054362812269,FALSE +"H520","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.21642,-0.754,0.813,17280,0.888,"PLCG2, ARPC5, CFL1, VAV3, PLPP1, PRKCA, ARPC1B, VAV2, ASAP3, PLPP3, ARPC2, GSN, RAC2, PIK3CD, CDC42, PLD1, SPHK1, PRKCD, VASP",0.0899094544059319,0.051587034221399,FALSE +"H520","Input","KEGG_FOCAL_ADHESION",-0.34036,-1.17,0.233,15230,0.692,"PIK3R1, ACTN2, RELN, VWF, LAMC3, FLT4, PDGFRA, COL11A1, ITGA2, COL5A1, COL5A3, MYLK, ITGB5, THBS2, ITGA2B, COL6A3, ITGA11, CCND2, PRKCG, AKT3, COL6A2, PDGFC, ACTG1, VEGFB, ITGA4, COL3A1, PDGFRB, PDGFA, LAMA1, BCAR1, COL1A2, LAMC2, RAP1B, COL5A2, ITGAV, ITGB8, COL4A2, ITGB6, ITGB3, LAMA4, CCND3, LAMB2, VAV3, MET, COL6A1, PRKCA, DOCK1, COL1A1, FLNC, RAP1A, PGF, VAV2, LAMA3, VEGFC, SHC1, BIRC3, ITGA5, MYL12A, TNC, ILK, COL4A1, MYL9, RAC2, VCL, LAMA5, FLNA, PIK3CD, ITGB1, MYL12B, PARVA, CDC42, LAMB3, CAPN2, ACTB, ERBB2, CAV2, RHOA, EGFR, CAV1, ITGA3, PXN, FLNB, IGF1R, LAMB1, VASP, ZYX",0.632644078973981,0.159893905543242,FALSE +"H520","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.27945,-1.02,0.404,15141,0.727,"ALPG, ALPL, ALPP, QDPR, SPR, FPGS",0.393618634889395,0.138465589140962,FALSE +"H520","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.22115,-0.776,0.737,16567,0.91,"FPGT, PFKFB4, MTMR6, PFKL, PHPT1, GMPPA, PFKFB2, PFKP",0.132532512140949,0.0409586076789064,FALSE +"H520","Input","KEGG_GALACTOSE_METABOLISM",-0.38693,-1.39,0.121,17740,0.727,"GLB1, B4GALT1, GALK1, GALE, PFKP, PGM1",0.91721462968355,0.138465589140962,FALSE +"H520","Input","KEGG_GAP_JUNCTION",0.32333,0.896,0.625,3267,0.977,"HTR2C, TUBB2B, MAP2K5, ADCY7, ITPR1, MAP2K1, TUBB2A, MAP2K2, MAP3K2, GNA11, CDK1, RAF1, ADRB1, PRKG2, SOS1, PRKX, ADCY1, PRKACB",0.204119982655925,0.0101054362812269,FALSE +"H520","Input","KEGG_GLIOMA",0.31251,0.877,0.642,6125,1,"IGF1, MAP2K1, MAP2K2, PIK3CA, BRAF, RAF1, MTOR, SOS1, E2F2, PIK3CB, CALML5, CDKN2A, SOS2, PIK3R2, AKT2, E2F1, RB1, CAMK2G, TGFA, CDK6, CALML6, EGF, MAPK1, E2F3, CALML3, CAMK2A, CALM3, PIK3R3",0.192464971931147,0,FALSE +"H520","Input","KEGG_GLUTATHIONE_METABOLISM",0.24475,0.681,0.921,2025,1,"SMS, GPX2, GSTA4, GCLC, TXNDC12, IDH1",0.0357403698031511,0,FALSE +"H520","Input","KEGG_GLYCEROLIPID_METABOLISM",0.40483,1.13,0.271,2416,0.838,"AKR1A1, LIPC, LCLAT1, DGKQ, DGKG, ALDH2, AGPAT4, GK, ALDH9A1, LPL",0.567030709125594,0.0767559813697235,FALSE +"H520","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.23019,-0.811,0.689,17148,0.878,"DGKH, LCAT, ACHE, AGPAT3, PISD, GPD2, PLPP1, LYPLA2, PCYT2, PLPP3, MBOAT7, AGPAT2, PLD1, DGKA, GPD1L",0.161780778092374,0.0565054840938974,FALSE +"H520","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.46351,1.29,0.12,2770,0.631,"PIPOX, PSPH, PHGDH, SHMT2, MAOB, CBS, CHDH, PSAT1",0.920818753952375,0.199970640755866,FALSE +"H520","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.22013,0.609,0.953,4876,1,"AKR1A1, PCK2, ALDH3A1, ALDH2, PDHA1, ALDH9A1, HK2, ADH5, ALDH3A2, DLAT, ENO3, ALDOB, ALDH7A1, ADH6",0.0209070993616736,0,FALSE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.23729,-0.872,0.628,16826,0.8,"XYLT1, CHST11, UST, CHST3, CHPF2",0.202040356262804,0.0969100130080564,FALSE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.26186,0.73,0.873,3513,1,"NDST2, B3GAT3, HS6ST1, GLCE, HS2ST1",0.0589857562944303,0,FALSE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.34902,-1.23,0.184,17016,0.698,"B3GNT7, ST3GAL1, B4GAT1, B3GNT2, FUT8, B4GALT1",0.735182176990464,0.156144577376839,FALSE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.28559,-1,0.333,12993,0.722,"NAGLU, HEXA, GUSB, HYAL4, SGSH, HYAL2, IDS, HGSNAT, HPSE, GLB1, HEXB, GNS, GALNS",0.47755576649368,0.141462802430361,FALSE +"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.51121,-1.79,0.0198,16108,1,"ST3GAL5, ST8SIA1, ST3GAL1, GLB1, HEXB, ST6GALNAC4, ST6GALNAC6",1.70333480973847,0,FALSE +"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.30192,-1.05,0.33,16360,0.683,"ST8SIA1, B3GALT5, GBGT1, ST3GAL1, NAGA, HEXB",0.481486060122112,0.165579296318467,FALSE +"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.50207,1.42,0.0773,2431,0.65,"B3GALT2, FUT1, B4GALT2, ST3GAL3, FUT7, FUT4, FUT9",1.11182050608168,0.187086643357144,FALSE +"H520","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.50654,1.41,0.072,5032,0.564,"PIGM, PIGX, PIGG, PIGQ, PIGH, PIGS, PIGA, PIGP, PIGN, PIGO, PGAP1, PIGV, PIGW",1.14266750356873,0.248720896016658,FALSE +"H520","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.61907,1.72,0.00777,4790,0.388,"HAO2, MTHFD2, PGP, MTHFD1L, AFMID, MTHFD2L, HYI, GRHPR",2.10957898119909,0.411168274405793,FALSE +"H520","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.26844,0.749,0.818,4479,1,"ADCY7, ITPR1, MAP2K1, ATF4, MAP2K7, MAP2K2, MAP3K4, MAP3K2, GNA11, MAP2K6, RAF1, MAPK9, SOS1, PLA2G12A, PRKX, ADCY1, PRKACB, CALML5, PLA2G3, SOS2, PLCB1, CAMK2G, MAP2K4",0.087246696328677,0,FALSE +"H520","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.26891,0.74,0.863,438,1,"PRF1",0.0639892042847904,0,FALSE +"H520","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.34723,0.965,0.521,5660,0.909,"BMP8A, SHH, CSNK1G3, BMP8B, WNT11, CSNK1G2, PTCH2, BMP7, CSNK1G1, PRKX, PRKACB, GSK3B, BMP4, WNT8B, FBXW11, RAB23, PRKACA, WNT5A, PTCH1, STK36, CSNK1E",0.283162276700476,0.0414361167780325,FALSE +"H520","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.29731,-1.07,0.337,15170,0.762,"ITGA1, TNF, CD1D, CSF1R, ITGA2, ITGAM, FCGR1A, CD55, ITGA2B, CD22, CD36, IL1A, CSF2, ANPEP, ITGA4, IL7, CD9, IL1B, CSF2RA, CD37, IL7R, IL6, ITGB3, ITGA5, IL6R, CD59, CSF1, ITGA3, IL4R",0.472370099128661,0.1180450286604,FALSE +"H520","Input","KEGG_HISTIDINE_METABOLISM",0.43296,1.21,0.188,2218,0.738,"LCMT1, MAOB, ALDH3A1, ALDH2, ALDH9A1, LCMT2, CNDP1",0.72584215073632,0.131943638176958,FALSE +"H520","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.50465,1.4,0.0763,5713,0.533,"POLD3, MUS81, RAD51C, RAD54B, RAD51B, RAD51, EME1, RAD50, BLM, XRCC2, RAD54L, RAD52, MRE11, RPA4, XRCC3, BRCA2, POLD2, RPA2",1.11747546204512,0.273272790973428,FALSE +"H520","Input","KEGG_HUNTINGTONS_DISEASE",0.3802,1.06,0.361,5916,0.879,"UCP1, NDUFS5, SOD1, ITPR1, SLC25A4, POLR2D, AP2B1, NDUFS7, POLR2G, CREB1, NDUFB10, POLR2H, COX4I1, UQCR11, NRF1, SDHB, NDUFA2, SP1, TBP, VDAC2, TFAM, NDUFA10, VDAC1, POLR2C, CREBBP, ATP5F1D, DCTN4, NDUFA9, POLR2E, COX7C, COX7A2L, NDUFA7, SIN3A, SLC25A5, ATP5F1C, UQCRQ, PPID, AP2M1, NDUFA4L2, COX5A, NDUFAB1, NDUFC2, ATP5MC3, NDUFB6, POLR2J, PLCB1, NDUFB7, CREB3L4, UQCRC2, NDUFS6, POLR2K, NDUFA4, NDUFS3, REST, NDUFA1, UQCRHL, NDUFB9, CYC1, EP300, HDAC2, NDUFB1, NDUFC1, UQCRB, ATP5F1A, DNAH1, NDUFV1, NDUFB5, AP2A2, CREB3, DCTN1, POLR2I, HAP1, HIP1, TBPL1",0.442492798094342,0.0560111249262281,FALSE +"H520","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.34828,-1.26,0.172,14536,0.68,"ITGA7, SGCD, ITGA10, TNNT2, ACE, ITGA1, TNF, SGCA, TNNC1, CACNG7, DES, ITGA2, ITGB5, CACNA2D4, ITGA2B, ITGA11, CACNA1C, CACNG6, ACTG1, CACNG4, ITGA4, CACNG8, ITGAV, ITGB8, IL6, ITGB6, ITGB3, TNNI3, CACNA2D1, TGFB3, TPM1, ITGA5, LMNA, DAG1, ITGB1, TGFB1, TPM2, ACTB, ITGA3, CACNB3, PRKAG2",0.764471553092451,0.167491087293764,FALSE +"H520","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.29103,0.815,0.748,5884,1,"PIP4K2B, MIOX, PIK3CA, OCRL, INPPL1, PIK3CB, PIKFYVE, PIK3C3, CDIPT, INPP5J, PLCD4, PIK3C2A, ITPKB, PLCB1, ALDH6A1, IMPA1, PIK3C2B, PI4KB, PIP5K1A, INPP5B, PIP5K1C, INPP5E, IPMK, INPP4A",0.126098402135539,0,FALSE +"H520","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.36694,1.03,0.41,4093,0.823,"EIF4EBP1, PHKB, PPP1R3B, MKNK2, MAP2K1, MAP2K2, SOCS4, SORBS1, PCK2, TSC2, PYGM, PIK3CA, PPP1CC, PDPK1, FLOT2, ACACA, BRAF, PHKA2, EIF4E, RAF1, MAPK9, MTOR, PHKA1, CBL, SOS1, EIF4E2, PIK3CB, PRKX, PRKAG1, HK2, PRKACB, RPS6KB2, PDE3B, CALML5, RPS6, SOCS1, PPP1CB, GSK3B, SOS2, PIK3R2, AKT2, PRKAB2, PHKG2",0.387216143280265,0.0846001647877302,FALSE +"H520","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.33611,0.929,0.576,597,0.944,"CCL27, MADCAM1, CXCR4",0.239577516576788,0.025028005701931,FALSE +"H520","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.20307,-0.725,0.853,16023,0.878,"IL13RA2, CCND2, AKT3, IL15, STAM2, CSF2, JAK3, CBLC, LEPR, IFNAR2, IL7, CSF2RA, SOCS2, STAT4, IL7R, IL6, CCND3, IFNGR1, STAT5A, STAM, CTF1, IL12A, PIAS3, JAK1, SPRY1, STAT5B, CISH, PIK3CD, IL6R, OSMR, LIF, IL6ST, CLCF1, SOCS3, IL4R, STAT6",0.069050968832477,0.0565054840938974,FALSE +"H520","Input","KEGG_LEISHMANIA_INFECTION",-0.36403,-1.36,0.0706,15651,0.715,"ITGAM, STAT1, NFKBIA, FCGR1A, FOS, FCGR2A, IL1A, ITGA4, TLR4, NCF2, IL1B, PTGS2, ITGB2, IFNGR1, MAPK11, TGFB3, C3, IL12A, JAK1, ITGB1, TGFB1",1.1511952989482,0.145693958198919,FALSE +"H520","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.35323,-1.3,0.117,14879,0.708,"CLDN4, CLDN14, ACTN1, CDH5, VCAM1, CLDN22, PIK3R1, ACTN2, MMP9, CYBB, JAM2, CLDN16, CXCL12, ITGAM, EZR, PRKCG, ESAM, ACTG1, ITGA4, BCAR1, NCF2, THY1, RAPGEF3, RAP1B, CLDN9, ITGB2, PLCG2, RASSF5, SIPA1, VAV3, PRKCA, MAPK11, PTK2B, RAP1A, VAV2, MYL12A, MYL9, RAC2, VCL, CLDN1, ICAM1, PIK3CD, ITGB1, MYL12B, CDC42, ACTB, RHOA, PXN, VASP, CD99",0.931814138253838,0.149966742310231,FALSE +"H520","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.63758,1.75,0.011,5612,0.639,"ALDH2, ALDH9A1, HADHA, ALDH3A2, ALDH7A1, EHHADH, YOD1, NAA80",1.95860731484178,0.1944991418416,FALSE +"H520","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.16716,0.476,0.998,14427,1,"PLA2G12A, PLA2G3, CYP3A4, PLA2G6, CYP3A7, PLA2G4B, PLA2G4E, CYP2J2, PLA2G10, PLA2G4A, CYP2C9, PLA2G2E, PLA2G2D, PLA2G2A, CYP2C18, PLA2G12B, CYP1A2, CYP3A43, PLA2G5, PLA2G2C, PLA2G2F, CYP3A5, CYP2C19, ALOX15, CYP2C8, PLA2G1B, AKR1B10",0.000869458712628891,0,FALSE +"H520","Input","KEGG_LONG_TERM_DEPRESSION",0.38407,1.07,0.359,2535,0.91,"IGF1, ITPR1, PPP2CA, MAP2K1, MAP2K2, BRAF, GNA11, RAF1, PRKG2, PPP2R1B, PLA2G12A",0.444905551421681,0.0409586076789064,FALSE +"H520","Input","KEGG_LONG_TERM_POTENTIATION",0.34937,0.991,0.48,6008,0.892,"ITPR1, MAP2K1, ATF4, MAP2K2, RPS6KA6, PPP1CC, BRAF, RAF1, CREBBP, PPP3R1, RPS6KA2, PRKX, ADCY1, PRKACB, CALML5, PPP1CB, PLCB1, CAMK2G, PRKACA, CALML6, EP300, MAPK1, CALML3, CAMK2A, CALM3",0.318758762624413,0.0496351456238769,FALSE +"H520","Input","KEGG_LYSINE_DEGRADATION",0.54166,1.52,0.0445,6899,0.593,"PIPOX, NSD3, KMT5A, NSD2, DOT1L, NSD1, ALDH2, SETD1A, ALDH9A1, HADH, HADHA, SETDB1, SETD1B, ALDH3A2, SUV39H2, ALDH7A1, DLST, EHHADH, KMT5C, ASH1L, ACAT1, SETDB2, AASDH, GCDH, KMT5B, PLOD3, EHMT2, ECHS1, EHMT1, SUV39H1",1.35163998901907,0.226945306635737,FALSE +"H520","Input","KEGG_LYSOSOME",-0.3038,-1.05,0.354,16611,0.683,"NAGPA, AP3B1, PLA2G15, LAMP1, SUMF1, ACP5, SLC11A1, M6PR, AP1S3, LAPTM4A, CLN5, GM2A, CTSV, NAGA, SMPD1, CTSL, LGMN, GLB1, HEXB, GNS, CTSS, CTSH, TPP1, NEU1, GALNS, FUCA1, NPC2, AP1S1, ABCA2, CTSB, CTSD, CD68, CD63, CLTCL1, CTSA, LIPA, TCIRG1",0.450996737974212,0.165579296318467,FALSE +"H520","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.30889,0.85,0.701,3881,1,"CACNA1E, FGF3, FGF19, FGF4, FGF21, CACNA2D3, MAP2K5, FGF20, TAOK1, GADD45G, PAK2, FGF9, PAK1, MKNK2, MAP2K1, FGFR1, NLK, ATF4, MAP2K7, MAP2K2, MAP3K13, RPS6KA6, ATF2, TGFB2, BRAF, MAP3K4, MAP3K2, DUSP16, MAPKAPK5, MAP2K6, RAF1, MAPK8IP3, MAPK9, IL1R2, ECSIT, SOS1, MAP3K7, FGFR3, PLA2G12A, DUSP14, DUSP6, PPP3R1, MAP4K3, NF1, RPS6KA2, PRKX, CACNA1B, PRKACB, FGF22, FGF13, TAOK2, PLA2G3, MAP4K1, HSPA1L, MAP4K2, SOS2, AKT2",0.154281982033341,0,FALSE +"H520","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.38264,1.07,0.35,445,0.91,"FOXA2, ONECUT1",0.455931955649724,0.0409586076789064,FALSE +"H520","Input","KEGG_MELANOGENESIS",0.36435,1.02,0.422,6351,0.828,"KITLG, DVL3, TCF7, ADCY7, FZD1, MAP2K1, MAP2K2, LEF1, WNT11, CREB1, TCF7L2, MC1R, RAF1, FZD3, CREBBP, DCT, CTNNB1, PRKX, ADCY1, PRKACB, FZD10, CALML5, GSK3B, WNT8B, PLCB1, CAMK2G, GNAI1, CREB3L4, PRKACA, WNT5A, CALML6, EP300, MAPK1, CALML3, CREB3, CAMK2A, CALM3, FZD8, FZD6, WNT16, WNT2B, DVL1",0.374687549038326,0.0819696632151199,FALSE +"H520","Input","KEGG_MELANOMA",0.48653,1.35,0.101,3954,0.656,"FGF3, FGF19, FGF4, IGF1, FGF21, FGF20, FGF9, MAP2K1, FGFR1, MAP2K2, PIK3CA, BRAF, RAF1, E2F2, PIK3CB, FGF22, FGF13, CDKN2A, PIK3R2, AKT2, E2F1",0.995678626217357,0.18309616062434,FALSE +"H520","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.23149,0.648,0.953,3224,1,"UGT2A1, AKR1C1, AKR1C2, ALDH3A1, GSTA4, AKR1C3, CYP1A1, EPHX1, ADH5",0.0209070993616736,0,FALSE +"H520","Input","KEGG_MISMATCH_REPAIR",0.37097,1.03,0.402,7112,0.823,"RFC4, POLD3, EXO1, RFC1, PMS2, RFC5, RPA4, MSH6, POLD2, RPA2, RFC3, RPA3, MSH2, RFC2",0.39577394691553,0.0846001647877302,FALSE +"H520","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.53531,1.48,0.0511,3881,0.663,"IGF1, EIF4EBP1, RPS6KA6, TSC2, PIK3CA, PDPK1, BRAF, STK11, MLST8, EIF4E, ULK1, MTOR, DDIT4, EIF4E2, PIK3CB, ULK3, RPS6KA2, VEGFA, RPS6KB2, RPS6, PIK3R2, EIF4B, AKT2",1.29157909986529,0.178486471595227,FALSE +"H520","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.25675,0.711,0.87,2852,1,"IFNA5, SYK, PRF1, PAK1, NFATC3, MAP2K1, ULBP1, MAP2K2, PIK3CA, PTPN11, BRAF, IFNAR1, RAF1, FYN, SOS1, PPP3R1, PIK3CB",0.0604807473813815,0,FALSE +"H520","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.39605,1.1,0.318,2107,0.892,"GPR50, GRM8, GRIK3, GPR83, GRM3, NMUR2, CHRM3, OPRD1, GABRA3, PTH2R, ADRA2C, HTR2C, GABRR2, LPAR6, SCTR, GABRG2, MCHR2, GABRR1, CHRNA7, P2RY11, GALR2, PTGER4, GABRQ, GALR3, LTB4R2, MC1R, LTB4R, P2RY14, ADRB1",0.497572880015567,0.0496351456238769,FALSE +"H520","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.21165,0.592,0.961,5375,1,"MAP2K5, SH2B1, MAP2K1, ATF4, MAP2K7, MAP2K2, RPS6KA6, PIK3CA, PTPN11, PDPK1, BRAF, RAF1, MAPK9, SOS1, PIK3CB, RPS6KA2, RIPK2, NFKBIB, CALML5, GSK3B, SOS2, PIK3R2, AKT2, CAMK2G, PRDM4, IRAK1, CRKL, NTRK2, BEX3, FASLG, CALML6, TP73, PSEN1, MAPK1",0.0172766123314547,0,FALSE +"H520","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.27808,-1.01,0.365,15820,0.725,"NT5M, PNP, BST1, NAMPT, NT5C2, AOX1, ENPP1, QPRT, NMNAT2, NNMT, NT5E",0.437707135543525,0.139661993429006,FALSE +"H520","Input","KEGG_NITROGEN_METABOLISM",0.56754,1.58,0.0328,1340,0.754,"CA6, CA7, GLUD2, CA8, ASNS",1.48412615628832,0.122628654130226,FALSE +"H520","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.29362,-1.09,0.253,16189,0.746,"NLRP3, NOD1, IKBKB, CCL5, IL1B, TNFAIP3, TAB3, IL6, CXCL1, MAPK11, CXCL2, CASP1, CXCL8, BIRC3, CARD6, IL18, NLRP1, TRIP6",0.596879478824182,0.127261172527331,FALSE +"H520","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.46733,1.31,0.117,7316,0.592,"XRCC5, RAD50, POLL, DNTT, MRE11, FEN1, LIG4, DCLRE1C, NHEJ1, XRCC6",0.931814138253838,0.22767829327708,FALSE +"H520","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.26708,0.751,0.857,5613,1,"MAP2K1, MAP2K2, PIK3CA, PDPK1, BRAF, RAF1, SOS1, E2F2, PIK3CB, CDKN2A, SOS2, PIK3R2, AKT2, E2F1, RB1, TGFA, CDK6, EGF, MAPK1, E2F3",0.0670191780768018,0,FALSE +"H520","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.37491,1.03,0.409,5494,0.823,"DVL3, MAML1, MAML2, CTBP1, LFNG, CREBBP, CIR1, RFNG, APH1A, PSEN2, DTX3, MAML3, KAT2A, EP300, HDAC2, ADAM17, PSEN1, SNW1, CTBP2",0.388276691992658,0.0846001647877302,FALSE +"H520","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.33699,0.93,0.562,5873,0.953,"RFC4, POLD3, ERCC4, RAD23A, GTF2H3, ERCC3, CUL4B, RFC1, CCNH, POLE, RFC5, RPA4, POLE4, XPC, DDB2, POLE3, POLD2, RPA2, DDB1, RFC3",0.250263684430939,0.0209070993616736,FALSE +"H520","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.38059,1.05,0.382,6489,0.867,"MGAT5, MAN1A1, MAN2A1, B4GALT2, ALG3, RPN1, ST6GAL1, MOGS, ALG9, ALG13, STT3B, MAN2A2, B4GALT3, RPN2, ALG1, GANAB, DOLPP1, ALG10B, MGAT4A, ALG5, ALG12, RFT1, MAN1C1, MGAT4B, STT3A",0.417936637088291,0.0619809025237897,FALSE +"H520","Input","KEGG_OLFACTORY_TRANSDUCTION",0.37001,1.02,0.412,1297,0.828,"OR10S1, OR6T1, OR4D5, OR2B3, OR6B2, OR5M11, OR10AD1, OR11H6, OR8S1, OR10AG1, OR13J1, GNAL, OR1J1",0.385102783966865,0.0819696632151199,FALSE +"H520","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.56465,1.56,0.0245,6339,0.711,"MTHFD2, SHMT2, ALDH1L1, GART, MTHFD1L, MTHFD2L, MTHFR, MTFMT, FTCD, DHFR, MTHFS",1.61083391563547,0.148130399270234,FALSE +"H520","Input","KEGG_OOCYTE_MEIOSIS",0.41586,1.16,0.238,5042,0.77,"IGF1, ADCY7, ITPR1, PPP2CA, MAP2K1, CDC23, RPS6KA6, PPP1CC, ESPL1, CDC20, CCNB2, CDK1, PLK1, PPP2R1B, CDC25C, STAG3, PPP3R1, MAD2L1, PKMYT1, RPS6KA2, PRKX, ANAPC7, ADCY1, PRKACB, ANAPC1, PPP2R5E, CALML5, SGO1, PPP1CB, CDC27, BUB1, AR, MAD2L2, CAMK2G, FBXW11, PPP2R5D, SKP1, ANAPC11, PRKACA, CALML6",0.623423042943488,0.113509274827518,FALSE +"H520","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.46682,-1.71,0.0426,17370,0.725,"MAN2B2, GLB1, HEXB, NEU1, FUCA1",1.37059040089728,0.139661993429006,FALSE +"H520","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.40796,1.14,0.242,5601,0.821,"ATP4A, NDUFS5, ATP6V0B, ATP5ME, ATP6V0A2, ATP6V1E2, NDUFS7, NDUFB10, PPA1, COX4I1, COX11, UQCR11, SDHB, NDUFA2, NDUFA10, ATP5F1D, NDUFA11, NDUFA9, COX7C, COX7A2L, NDUFA7, ATP6V1G2, ATP5F1C, ATP6V0C, UQCRQ, ATP6V1H, NDUFA4L2, COX5A, NDUFAB1, NDUFC2, ATP5MC3, NDUFB6, NDUFB7, UQCRC2, NDUFS6, NDUFA4, NDUFS3, NDUFA1, UQCRHL, NDUFB9, CYC1, ATP6V0E2, ATP6V0A1, NDUFB1, NDUFC1, UQCRB, ATP6V1A, ATP5F1A, NDUFV1, NDUFB5",0.616184634019569,0.0856568428805592,FALSE +"H520","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.38591,1.08,0.349,1096,0.928,"GALNT10, GALNT13, GCNT1, GALNT6",0.45717457304082,0.0324520237811379,FALSE +"H520","Input","KEGG_P53_SIGNALING_PATHWAY",0.29023,0.806,0.756,2571,1,"IGF1, GADD45G, SESN2, SIAH1, RPRM, COP1, TSC2, CCNB2, CDK1, TP53AIP1, CHEK1, CCNG1, ATM",0.121478204498793,0,FALSE +"H520","Input","KEGG_PANCREATIC_CANCER",-0.29123,-1.06,0.374,17729,0.751,"RALBP1, RALGDS, TGFB3, PGF, VEGFC, JAK1, RAC2, TP53, PIK3CD, CDC42, PLD1, TGFB1, ERBB2, EGFR, TGFBR2, RALB",0.42712839779952,0.124360062995832,FALSE +"H520","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.28974,0.811,0.761,6096,1,"PANK3, PPCDC, COASY, PPCS, PANK4, PANK1, PANK2",0.118615343229427,0,FALSE +"H520","Input","KEGG_PARKINSONS_DISEASE",0.40031,1.11,0.296,6850,0.873,"NDUFS5, SLC18A2, SLC25A4, NDUFS7, NDUFB10, COX4I1, UQCR11, SDHB, NDUFA2, VDAC2, NDUFA10, VDAC1, ATP5F1D, NDUFA9, COX7C, COX7A2L, NDUFA7, SLC25A5, ATP5F1C, UQCRQ, PPID, UCHL1, NDUFA4L2, UBE2J2, COX5A, NDUFAB1, NDUFC2, ATP5MC3, NDUFB6, NDUFB7, UQCRC2, PARK7, NDUFS6, NDUFA4, NDUFS3, NDUFA1, UQCRHL, NDUFB9, CYC1, NDUFB1, NDUFC1, UQCRB, ATP5F1A, NDUFV1, NDUFB5, UBE2J1, UBE2L6, PINK1, CASP9, UQCRFS1, COX8A, NDUFS1, NDUFA6, CASP3, COX6A1, SNCA, COX7B, ATP5MC2",0.528708288941061,0.0589857562944303,FALSE +"H520","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.32967,-1.18,0.214,16265,0.766,"TUBB8, ACTG1, TLR4, TUBB4B, TLR5, TUBB, ARPC5, PRKCA, ARPC1B, ARPC2, CLDN1, ITGB1, CDC42, TUBB6, ACTB, RHOA, TUBA4A",0.669586226650809,0.115771230367396,FALSE +"H520","Input","KEGG_PATHWAYS_IN_CANCER",0.28208,0.787,0.795,4222,1,"FGF3, FGF19, FGF4, IGF1, ZBTB16, FGF21, KITLG, CTNNA2, DVL3, AXIN2, TCF7, FGF20, SHH, FGF9, APC, FZD1, RUNX1, MAP2K1, FGFR1, DAPK2, MAP2K2, LEF1, VHL, WNT11, CTBP1, TCF7L2, LAMC1, PIK3CA, TGFB2, BRAF, RAF1, FZD3, PIAS4, MAPK9, CREBBP, PTCH2, MTOR, CTNNA1, EGLN2, CBL, SOS1, SMAD4, FGFR3, XIAP, EGLN1, E2F2, AXIN1, PIK3CB, CTNNB1, RAD51, ELOB, FH, VEGFA, SKP2, FGF22, TRAF4, SLC2A1, FZD10, FGF13, CKS1B, BIRC5, ARNT, ARNT2, CDKN2A, GSK3B, APPL1, SOS2, PIK3R2, AKT2, TPR, BMP4, E2F1, EPAS1, TGFBR1, WNT8B, AR, RAC3, RB1, PTK2",0.0996328713435297,0,FALSE +"H520","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.25667,0.725,0.878,2705,1,"UGT2A1, DCXR",0.0565054840938974,0,FALSE +"H520","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.323,-1.17,0.185,18666,0.692,"DERA, PFKP, PGM1",0.732828271596986,0.159893905543242,FALSE +"H520","Input","KEGG_PEROXISOME",0.35016,0.974,0.495,2893,0.906,"HAO2, PIPOX, PRDX1, SOD1, MPV17L, PEX12, PEX2, IDH1, PECR, SLC27A2, PEX14, PEX5, PEX11G, ABCD4, PEX16",0.305394801066431,0.0428718023231869,FALSE +"H520","Input","KEGG_PHENYLALANINE_METABOLISM",0.50311,1.4,0.0756,1326,0.533,"PAH, GOT2, MAOB, ALDH3A1",1.12147820449879,0.273272790973428,FALSE +"H520","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.27782,0.779,0.799,6125,1,"DGKQ, ITPR1, PIP4K2B, DGKG, PIK3CA, OCRL, INPPL1, PIK3CB, PIKFYVE, PIK3C3, CDIPT, CALML5, INPP5J, PLCD4, PIK3C2A, PIK3R2, ITPKB, PLCB1, IMPA1, DGKE, PIK3C2B, PI4KB, CALML6, PIP5K1A, INPP5B, CDS1, PIP5K1C, CALML3, INPP5E, INPP4A, CALM3, PIK3R3",0.0974532206860086,0,FALSE +"H520","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.40398,1.12,0.287,2577,0.855,"UROD, UGT2A1, EARS2, FECH, HMBS",0.542118103266008,0.0680338852718274,FALSE +"H520","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.32613,0.91,0.601,3610,0.962,"ADIPOQ, UCP1, SORBS1, PCK2, PDPK1, GK, ME1, LPL, SLC27A2, FADS2, NR1H3, SLC27A5",0.22112552799726,0.0168249279621871,FALSE +"H520","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.27586,-0.959,0.429,17295,0.723,"ACOX2, CYP39A1, SCP2",0.367542707815276,0.140861702705469,FALSE +"H520","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.19981,0.552,0.983,4361,1,"RFXAP, TNFRSF13C, RAG1, RFX5, IGLL1, CD8A",0.00744648216786438,0,FALSE +"H520","Input","KEGG_PRION_DISEASES",0.35537,0.984,0.499,5375,0.888,"SOD1, MAP2K1, MAP2K2, LAMC1, FYN, PRKX, PRKACB, NCAM1, STIP1, PRKACA, MAPK1",0.30189945437661,0.051587034221399,FALSE +"H520","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.43344,1.2,0.196,4986,0.731,"IGF1, ADCY7, MAP2K1, CDC23, FZR1, RPS6KA6, PIK3CA, BRAF, CCNB2, CDK1, RAF1, PLK1, MAPK9, CDC25C, MAD2L1, PKMYT1, PIK3CB, RPS6KA2, PRKX, ANAPC7, ADCY1, PRKACB, ANAPC1, PDE3B, PIK3R2, AKT2, CDC27, BUB1, MAD2L2, GNAI1, ANAPC11, PRKACA, CCNA2",0.707743928643524,0.13608262304214,FALSE +"H520","Input","KEGG_PROPANOATE_METABOLISM",0.44919,1.27,0.153,5901,0.649,"ACSS3, ALDH2, ACACA, ALDH9A1, HADHA, HIBCH, ALDH3A2, ACACB, ALDH6A1, ALDH7A1, PCCB, EHHADH, MLYCD, SUCLA2, SUCLG1, MCEE, ACAT1",0.815308569182401,0.187755303199631,FALSE +"H520","Input","KEGG_PROSTATE_CANCER",0.3433,0.949,0.524,4584,0.933,"IGF1, TCF7, MAP2K1, FGFR1, ATF4, MAP2K2, LEF1, CREB1, TCF7L2, PIK3CA, PDPK1, BRAF, RAF1, CREBBP, MTOR, SOS1, E2F2, PIK3CB, CTNNB1, GSK3B, SOS2, PIK3R2, AKT2, E2F1, AR, RB1, CREB3L4, TGFA",0.280668713016273,0.0301183562535,FALSE +"H520","Input","KEGG_PROTEASOME",0.28788,0.803,0.774,7640,1,"PSMD7, PSMD2, PSMB11, PSMD11, PSMD14, PSME4, PSMC3, PSME3, PSMD8, PSMA3, PSMA4, PSMD1, PSMC5, PSMB1, PSME2, PSMC6, PSMD3, PSMD6, PSMD4, PSMA2, PSMC2, PSMC1",0.111259039317107,0,FALSE +"H520","Input","KEGG_PROTEIN_EXPORT",0.46945,1.31,0.111,3508,0.592,"SRPRB, IMMP1L, SRP19, SEC63, SEC61A1, SEC11A, SRP9, SEC62, SEC11C",0.954677021213343,0.22767829327708,FALSE +"H520","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.37818,1.05,0.364,1596,0.867,"GLUD2, PCK2, SLC25A10",0.438898616350944,0.0619809025237897,FALSE +"H520","Input","KEGG_PURINE_METABOLISM",0.34935,0.986,0.478,4730,0.895,"PDE8B, ENTPD8, ENTPD3, ENTPD1, PDE6B, ADCY7, PAPSS1, POLR2D, ALLC, GMPS, POLR3A, POLR2G, PDE4D, POLA1, POLD3, PDE5A, POLR2H, GART, NUDT2, PDE7A, POLR2C, POLR2E, RRM1, PRUNE1, PRPS2, ADCY1, NPR2, PDE3B, PPAT, POLR1E, POLR3G, GMPR, NME2, PAICS, NT5C3A, POLR2J, APRT, POLR1D, PDE11A, PRPS1, ADK, POLE, NT5C, POLR2K",0.320572103387881,0.048176964684088,FALSE +"H520","Input","KEGG_PYRIMIDINE_METABOLISM",0.32743,0.918,0.588,4135,0.963,"ENTPD8, ENTPD3, ENTPD1, UCK2, POLR2D, POLR3A, POLR2G, DUT, POLA1, POLD3, POLR2H, CTPS1, NUDT2, CTPS2, POLR2C, DTYMK, POLR2E, RRM1, CAD, DHODH, UMPS, POLR1E, UCK1, POLR3G, NME2, NT5C3A, POLR2J, POLR1D",0.230622673923862,0.0163737128754655,FALSE +"H520","Input","KEGG_PYRUVATE_METABOLISM",0.37537,1.04,0.39,4790,0.843,"PCK2, ALDH2, PDHA1, ACACA, HAGH, ACYP1, ALDH9A1, ME1, ALDH3A2, DLAT, ACACB, ALDH7A1, GRHPR",0.408935392973501,0.0741724253752577,FALSE +"H520","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.2637,0.734,0.86,3904,1,"FGF3, FGF19, FGF4, CHRM3, FGF21, FGF20, PAK2, FGF9, APC, PAK1, PIP4K2B, MAP2K1, FGFR1, MYL5, MAP2K2, MYLK2, PIK3CA, PPP1CC, BRAF, RAF1, IQGAP3, SOS1, FGFR3, CYFIP2, GIT1, TIAM1, PIK3CB, PFN2, PIKFYVE, WAS, FGF22, FGF13, ACTN4, NCKAP1, CYFIP1, PPP1CB, SOS2, PIK3R2, DIAPH1",0.0655015487564323,0,FALSE +"H520","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.47332,1.34,0.0905,3806,0.625,"IFNA5, ATG4D, ULK1, GABARAPL2, ATG4B, ULK3, PIK3C3, ATG12, IFNA21",1.0433514207948,0.204119982655925,FALSE +"H520","Input","KEGG_RENAL_CELL_CARCINOMA",0.36288,1.01,0.434,4593,0.846,"PAK2, PAK1, MAP2K1, MAP2K2, VHL, PIK3CA, PTPN11, TGFB2, BRAF, RAF1, CREBBP, EGLN2, SOS1, EGLN1, PIK3CB, ELOB, FH, VEGFA, SLC2A1, ARNT, ARNT2, SOS2, PIK3R2, AKT2, EPAS1, VEGFD, TGFA, CRKL",0.362510270487489,0.0726296369609765,FALSE +"H520","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.28008,0.77,0.813,4171,1,"THOP1, CMA1, NLN, MME",0.0899094544059319,0,FALSE +"H520","Input","KEGG_RETINOL_METABOLISM",0.3055,0.862,0.674,4876,1,"UGT2A1, RDH11, CYP1A1, RDH12, ALDH1A1, ADH5, PNPLA4, CYP3A4, DHRS4, DHRS4L2, ALDH1A2, ADH6",0.17134010346468,0,FALSE +"H520","Input","KEGG_RIBOFLAVIN_METABOLISM",0.50449,1.41,0.0691,2284,0.564,"MTMR2, RFK, ACP1, ACP4",1.1605219526258,0.248720896016658,FALSE +"H520","Input","KEGG_RIBOSOME",0.18726,0.519,0.994,5341,1,"RPS8, RPS28, RSL24D1, RPL22, RPL35A, MRPL13, RPLP0, RPL23A, RPS15, RPS6, RPL36, RPS2, RPS24, RPL18A, RPL4, RPS15A, RPL17, RPL26L1, FAU, RPLP1",0.00261361560268669,0,FALSE +"H520","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.20526,-0.769,0.835,17783,0.903,"MAPK11, CXCL8, IL12A, IRF3, TBK1, CASP10, TRADD, TBKBP1, IKBKE",0.0783135245163979,0.0443122496864942,FALSE +"H520","Input","KEGG_RNA_DEGRADATION",0.54896,1.52,0.0483,4748,0.593,"CNOT1, EXOSC6, CNOT8, LSM1, CNOT6, DCP2, HSPA9, PAPOLG, EDC4, CNOT9, LSM7, EXOSC3, DCP1A, PARN, LSM3, EXOSC8, HSPD1, DCPS, DDX6, LSM4, XRN1, TENT4A, EDC3, CNOT7, CNOT6L, TTC37, EXOSC1, ENO3, EXOSC5, ZCCHC7",1.31605286924849,0.226945306635737,FALSE +"H520","Input","KEGG_RNA_POLYMERASE",0.41161,1.16,0.247,4730,0.77,"POLR2D, POLR3A, POLR2G, POLR2H, POLR2C, POLR2E, POLR1E, POLR3G, POLR2J, POLR1D, POLR2K",0.607303046740334,0.113509274827518,FALSE +"H520","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.51987,1.44,0.0633,2788,0.683,"LCMT1, PAPSS1, CBS, MAT2A, SEPHS2, MAT2B, LCMT2, SEPHS1, SCLY",1.19859628998265,0.165579296318467,FALSE +"H520","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.28067,-0.998,0.477,15230,0.702,"PIK3R1, LAMC3, TRAF3, ITGA2, NFKBIA, ITGA2B, CCNE1, AKT3, IKBKB, MAX, LAMA1, LAMC2, PTGS2, ITGAV, COL4A2, TRAF5, LAMA4, LAMB2, RXRA, LAMA3, BIRC3, PIAS3, COL4A1, TP53, LAMA5, PIK3CD, ITGB1, LAMB3, ITGA3, LAMB1",0.321481620959886,0.153662887870195,FALSE +"H520","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.37511,1.05,0.376,3953,0.867,"GOSR1, STX5, SEC22B, USE1, TSNARE1, VAMP1, STX6, SNAP47, VAMP2, STX10, BNIP1, STX17",0.424812155072339,0.0619809025237897,FALSE +"H520","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.3388,-1.26,0.146,17158,0.68,"SPTLC1, SGMS1, PLPP1, SMPD1, GLB1, PLPP3, SGMS2, NEU1, UGCG, SPHK1, SMPD2",0.835647144215563,0.167491087293764,FALSE +"H520","Input","KEGG_SPLICEOSOME",0.46757,1.31,0.108,5966,0.592,"PPIE, TRA2B, CTNNBL1, RBM17, ISY1, XAB2, PPIH, THOC3, SF3A2, LSM7, NCBP2, SNRPA, DHX8, SRSF5, HNRNPA1L2, LSM3, HNRNPM, SLU7, HNRNPU, HNRNPA1, USP39, RBMX, RBM22, SRSF3, SRSF10, SF3B1, THOC1, ZMAT2, DDX5, LSM4, BUD31, SRSF9, DHX38, TXNL4A, PRPF40A, U2SURP, DDX46, HSPA1L, THOC2, SRSF1, SMNDC1, AQR, CDC40, ALYREF, CHERP, SNRPF, SNRNP200, PRPF40B, HNRNPA3, SRSF8, SNRPG, SRSF2, PRPF3, DHX16, SART1, RBM8A, SNW1, MAGOHB, SRSF7, BCAS2, SF3A1, DDX42, SNRPD1, PLRG1, LSM5, HNRNPK, TCERG1, SNRPA1",0.96657624451305,0.22767829327708,FALSE +"H520","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.23507,-0.88,0.636,16846,0.85,"UGDH, GYS1, ENPP1, UXS1, AMY2B, PYGB, PGM1",0.196542884351586,0.0705810742857073,FALSE +"H520","Input","KEGG_STEROID_BIOSYNTHESIS",-0.39516,-1.4,0.121,16365,0.815,"SQLE, DHCR24, MSMO1, LIPA",0.91721462968355,0.0888423912600234,FALSE +"H520","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38192,1.07,0.356,4734,0.91,"UGT2A1, AKR1C1, AKR1C2, SRD5A3, AKR1C3, CYP1A1, HSD17B12, CYP3A4, SRD5A1, HSD11B2, AKR1C4, HSD17B8, SULT1E1",0.448550002027125,0.0409586076789064,FALSE +"H520","Input","KEGG_SULFUR_METABOLISM",0.42826,1.18,0.215,5228,0.759,"PAPSS1, SUOX, SULT1A3, BPNT1, SULT1E1, SULT1A4, SULT1A1",0.667561540084395,0.11975822410452,FALSE +"H520","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.38175,-1.34,0.141,13039,0.687,"IL10, FCGR2B, FCGR2C, GRIN2A, C1R, C6, C4B, C2, GRIN2B, C7, SNRPB, ACTN1, TNF, ACTN2, C4A, FCGR1A, ELANE, C1S, TRIM21, FCGR2A, CD40, C3",0.85078088734462,0.16304326294045,FALSE +"H520","Input","KEGG_TASTE_TRANSDUCTION",0.20059,0.561,0.982,5077,1,"GNB1, SCNN1A, PRKX, CACNA1B, PRKACB, TAS1R3, GNB3, GNG3, PRKACA, TAS2R46, TAS2R14",0.00788851221305034,0,FALSE +"H520","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.53476,1.47,0.0499,2943,0.636,"ADO, CSAD, GAD1",1.30189945437661,0.196542884351586,FALSE +"H520","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.25099,-0.899,0.578,4793,0.823,"GGPS1, ACAT1, ACAT2, PDSS1, MVD, IDI2, FDPS, PMVK, DHDDS, HMGCS1, MVK, HMGCR, HMGCS2, IDI1, PDSS2",0.238072161579471,0.0846001647877302,FALSE +"H520","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.3788,1.06,0.373,6086,0.879,"BMP8A, NODAL, INHBE, INHBC, PPP2CA, AMH, BMP8B, ID4, SP1, TGFB2, THBS4, SMAD9, SMAD5, CREBBP, BMP7, SMAD4, PPP2R1B, SMAD1, INHBB, RBL1, ID3, RPS6KB2, E2F4, RBL2, BMP4, TGFBR1, SKP1, SMAD2, SMAD6, EP300, BMPR1A, MAPK1, SMAD7, MYC, BMPR2, ROCK2, CDKN2B, ACVR2B, RPS6KB1",0.428291168191312,0.0560111249262281,FALSE +"H520","Input","KEGG_THYROID_CANCER",0.43985,1.24,0.178,1729,0.702,"TCF7, MAP2K1, MAP2K2, LEF1, TCF7L2, BRAF",0.749579997691106,0.153662887870195,FALSE +"H520","Input","KEGG_TIGHT_JUNCTION",0.23182,0.649,0.941,4500,1,"MYH7B, CTNNA2, PRKCQ, PPP2CA, CSNK2A2, MYL5, RAB3B, MYH11, PPP2R2C, EPB41L3, PATJ, CTNNA1, PPP2R1B, CTNNB1, CRB3, ACTN4, PARD6A, MAGI1, LLGL2, F11R, AKT2, CLDN7, AFDN, PRKCZ, GNAI1, TJAP1, MYH3",0.0264103765727431,0,FALSE +"H520","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.18983,0.528,0.997,4567,1,"IFNA5, MAP2K1, MAP2K7, MAP2K2, PIK3CA, MAP2K6, IFNAR1, MAPK9, MAP3K7, PIK3CB, SPP1, TIRAP, IFNA21, PIK3R2, AKT2, TAB1, MAP2K4, IRAK1",0.00130484168834428,0,FALSE +"H520","Input","KEGG_TRYPTOPHAN_METABOLISM",0.35087,0.97,0.508,2805,0.906,"MAOB, WARS2, ALDH2, ALDH9A1, CYP1A1, HADH, HADHA, AFMID",0.294136287716081,0.0428718023231869,FALSE +"H520","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.43421,1.21,0.194,3844,0.738,"CACNA1E, ADIPOQ, SOCS4, PIK3CA, MAPK9, MTOR, PIK3CB, KCNJ11, CACNA1B, HK2, ABCC8, SOCS1, PIK3R2",0.712198270069774,0.131943638176958,FALSE +"H520","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.30032,0.832,0.735,4971,1,"PRF1, ICA1, HSPD1, GAD1, LTA, CPE, FASLG",0.133712660915805,0,FALSE +"H520","Input","KEGG_TYROSINE_METABOLISM",0.33098,0.913,0.586,3224,0.965,"LCMT1, GOT2, MAOB, DBH, ALDH3A1, LCMT2, DCT, ADH5",0.232102383981909,0.0154726866562074,FALSE +"H520","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.34281,0.944,0.55,4425,0.936,"CTLA4, MALT1, PAK2, PAK1, PRKCQ, NFATC3, MAP2K1, MAP2K7, MAP2K2, PIK3CA, PDPK1, RAF1, MAPK9, FYN, CBL, SOS1, MAP3K7, PPP3R1, PIK3CB, NFKBIB, NCK1, GSK3B, SOS2, PIK3R2, AKT2, PTPN6, CD8A, DLG1",0.259637310505756,0.0287241512618947,FALSE +"H520","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.43433,1.2,0.188,5850,0.731,"UBE2NL, UBE2D2, UBE2QL1, CDC34, KEAP1, UBE2R2, UBE2I, UBE2B, SIAH1, CDC23, FZR1, WWP1, VHL, COP1, CDC20, MGRN1, CUL5, PIAS4, CBL, UBE3A, XIAP, UBE2N, WWP2, CUL3, UBA2, CUL4B, ELOB, ANAPC7, SYVN1, HERC2, HERC1, KLHL9, SKP2, ANAPC1, UBE2Q1, SOCS1, UBE2J2, UBE2A, CDC27, STUB1, FANCL, UBE4B, FBXW11, RNF7, PIAS2, UBE2D3, SKP1, UBE2W, TRIM37, UBE2K, FBXW7, UBR5, ANAPC11, UBE2S, UBE4A, UBE2O, DDB2, PIAS1, BIRC6, MID1, TRIP12, BRCA1, UBE2J1, DDB1, UBE2M, FBXW8",0.72584215073632,0.13608262304214,FALSE +"H520","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.47841,1.33,0.0952,7811,0.603,"PDHA1, LARS2, IARS2, BCAT2, BCAT1, VARS2",1.02136305161553,0.219682687859849,FALSE +"H520","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.37206,1.04,0.403,6698,0.843,"OXCT2, ACAA2, ALDH2, ALDH9A1, HADH, HADHA, HIBCH, BCKDHA, ALDH3A2, IVD, ACAD8, ALDH6A1, DBT, MCCC2, MCCC1, ALDH7A1, ACADSB, PCCB, EHHADH, MCEE, ACAT1, BCKDHB, HSD17B10, OXCT1, ECHS1",0.39469495385889,0.0741724253752577,FALSE +"H520","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.24862,0.697,0.905,3711,1,"ADCY7, ITPR1, PRKCQ, MAP2K1, MAP2K2, MYLK2, MYH11, PPP1CC, BRAF, GNA11, RAF1, KCNMA1, PLA2G12A, PRKX, ARHGEF11, KCNMB3, ADCY1, NPR2, PRKACB, CALML5, PLA2G3, PPP1CB",0.0433514207947967,0,FALSE +"H520","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.34212,0.964,0.52,5771,0.9,"DYNC1I1, DYNC1LI2, RAB11B, DCTN5, CREB1, DCTN4, PRKX, VAMP2, PRKACB, RAB11A, CREB3L4, DYNLL2, PRKACA, DYNC1H1, RAB5A, CREB3, DCTN1",0.283996656365201,0.0457574905606751,FALSE +"H520","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.21206,-0.746,0.778,16861,0.865,"SH2D2A, PTGS2, NOS3, NFATC2, PLCG2, PRKCA, MAPK11, NFATC1, RAC2, PIK3CD, CDC42, HSPB1, SPHK1, PXN",0.109020403010311,0.0629838925351858,FALSE +"H520","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.25291,-0.922,0.532,17236,0.79,"ATP6V1E1, PDIA4, PLCG2, ERO1A, GNAS, ATP6V1B1, PRKCA, ATP6V1G1, ADCY9, ATP6V1F, ACTB, KDELR3, TCIRG1",0.274088367704952,0.102372908709559,FALSE +"H520","Input","KEGG_VIRAL_MYOCARDITIS",0.24931,0.698,0.897,2208,1,"MYH7B, PRF1, MYH11, SGCG, FYN",0.0472075569559079,0,FALSE +"H520","Input","KEGG_WNT_SIGNALING_PATHWAY",0.37476,1.06,0.378,6720,0.879,"NKD1, WIF1, DKK2, DVL3, TBL1XR1, AXIN2, TCF7, SENP2, APC, PPP2CA, CSNK2A2, SIAH1, NFATC3, FZD1, NLK, TBL1X, LEF1, WNT11, CTBP1, TCF7L2, FZD3, MAPK9, CREBBP, SMAD4, MAP3K7, LRP6, PPP2R1B, NKD2, PPP3R1, AXIN1, CACYBP, CTNNB1, PRKX, RUVBL1, PRKACB, PPP2R5E, FZD10, GSK3B, WNT8B, RAC3, PLCB1, CAMK2G, FBXW11, PPP2R5D, SKP1, FRAT2, LRP5, SMAD2, CSNK2A1, PRKACA, WNT5A, PPARD, EP300, FRAT1, PSEN1, SFRP5, CTBP2, MYC, CSNK1E, ROCK2, CAMK2A, VANGL1, PPP2R5C, FZD8, FZD6, PPP2R5A, WNT16, WNT2B, DVL1, JUN, NFATC4, DVL2, NFAT5, CHD8, MAPK8, WNT6",0.422508200162775,0.0560111249262281,FALSE +"H460","Input","KEGG_ABC_TRANSPORTERS",0.42084,1.55,0.0687,3238,0.202,"ABCC9, ABCB10, ABCC2, ABCA8, ABCG2, ABCB6, ABCB7, TAP2, ABCB1, ABCC3, ABCB8, ABCA2, ABCC1",1.16304326294045,0.694648630553376,FALSE +"H460","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.49963,-1.72,0.0358,16075,0.31,"LEF1, TCF7, SOS1, RARA, RUNX1, RAF1, STAT5A, PIM1, KRAS, PIK3CD, RPS6KB2, PIK3R3, AKT2, NRAS, RELA, BRAF, MAPK3, MAPK1, TCF7L1, SOS2, PPARD, STAT3, PIK3CA",1.44611697335613,0.508638306165727,FALSE +"H460","Input","KEGG_ADHERENS_JUNCTION",-0.51863,-1.8,0.0127,16075,0.493,"LEF1, PTPRF, TCF7, PTPRB, AFDN, CDH1, BAIAP2, RAC1, SORBS1, EP300, MAP3K7, RAC2, MAPK3, INSR, CTNND1, MAPK1, PTPN1, CDC42, NECTIN2, TCF7L1, CREBBP, NLK, SMAD3, WASF2, NECTIN3, TGFBR2, LMO7, CSNK2B, FYN, CSNK2A1",1.89619627904404,0.30715308072277,FALSE +"H460","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.24182,-0.844,0.663,16420,0.835,"MAPK10, PRKAB1, ACSL5, AKT2, RELA, ADIPOR2, NFKBIE, PPARA, CPT1B, MAPK8, STAT3, RXRB",0.178486471595227,0.0783135245163979,FALSE +"H460","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.31223,1.12,0.26,2951,0.407,"CPS1, GOT2, CAD, ADSL, ASS1, PPAT, GOT1",0.585026652029182,0.39040559077478,FALSE +"H460","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.3695,-1.28,0.17,11790,0.427,"FXYD2, SCNN1G, KCNJ1, ATP1B2, PIK3R2, HSD11B1, SCNN1B, PDPK1, PIK3CB, PRKCG, PIK3R1, ATP1A1, NR3C2, NEDD4L, SCNN1A, KRAS, PIK3CD, PIK3R3, MAPK3, INSR, MAPK1, PIK3CA",0.769551078621726,0.369572124974976,FALSE +"H460","Input","KEGG_ALLOGRAFT_REJECTION",0.34225,1.23,0.207,12576,0.338,"CD40, FAS, IL12A, CD86, CD80, PRF1, IFNG, CD40LG, IL2, CD28, GZMB, FASLG, IL5, IL4, IL10, IL12B, TNF",0.684029654543082,0.471083299722345,FALSE +"H460","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.24553,-0.842,0.662,18188,0.827,"PLA2G6, ACOX3",0.1791420105603,0.0824944904474534,FALSE +"H460","Input","KEGG_ALZHEIMERS_DISEASE",0.39065,1.37,0.123,3200,0.276,"CASP7, ATP5F1B, NDUFB10, SNCA, CASP9, NAE1, NDUFS2, ATP5MC1, HSD17B10, UQCRC2, ATP5MC3, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, NDUFB8, COX7C, CALM1, NDUFA5, NDUFA1, PLCB1, COX5A, COX7B, ITPR1, MAPT, IDE, GAPDH, NDUFB3, UQCRQ, NDUFB1, COX5B, CASP8, NDUFS6, SDHC, ATP5F1A, UQCRHL, SDHB, ATP5F1C, TNFRSF1A, NDUFS7, ATF6, NDUFV3, ATP5MC2, ATP5F1D, NDUFS4, NDUFA7, NDUFC1, COX6A1, COX6B1, UQCRH, PSEN2, CYCS, BACE2, SDHD, NDUFS5",0.910094888560602,0.559090917934782,FALSE +"H460","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.6345,2.32,0.00617,1069,0.0689,"IARS2, MARS2, FARSB, EARS2, DARS2, MTFMT, HARS2, LARS2, TARS2",2.20971483596676,1.16178077809237,TRUE +"H460","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.23375,0.845,0.59,4169,0.741,"UGDH, GPI, GALK2, PMM2, GNPDA1, GNPDA2, GNPNAT1, NANS, PGM2, HK1, HK2, NPL, NANP, GALE",0.229147988357856,0.130181792020672,FALSE +"H460","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.28873,-0.998,0.418,16132,0.657,"DERL1, CCS, PPP3CB, APAF1, MAPK13, CASP1, PPP3CA, RAC1, MAPK14, BCL2L1, RAB5A, CAT",0.378823718224965,0.182434630440219,FALSE +"H460","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.35367,1.27,0.167,1789,0.329,"HSP90AA1, CTSL, CANX, IFNA21, HSP90AB1, HSPA5, PSME3, HSPA1A, HSPA8, HSPA1B, TAP2, HSPA4",0.777283528852417,0.482804102050026,FALSE +"H460","Input","KEGG_APOPTOSIS",0.22691,0.825,0.658,1947,0.755,"CASP7, CASP9, AIFM1, NTRK1, IKBKG, ENDOG, TNFRSF10A, IRAK1, TRADD, BCL2, AKT1, PRKX, PRKAR1A, CHUK, CASP8",0.181774106386044,0.122053048370812,FALSE +"H460","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.46452,1.68,0.0538,656,0.169,"HPGDS, PLA2G4A, AKR1C3, GGT1, PTGES2, GPX3",1.26921772433361,0.772113295386326,FALSE +"H460","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.42754,1.51,0.0717,1837,0.21,"CPS1, GOT2, ALDH9A1, ODC1, ALDH18A1, CKB, SRM, LAP3, PYCR2, ALDH3A2, P4HA3, AGMAT, ALDH1B1, PYCR1",1.1444808443322,0.677780705266081,FALSE +"H460","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.26891,-0.929,0.527,11469,0.718,"SGCG, CACNG6, SGCA, CTNNA2, DAG1, SGCD, ITGB8, CACNG7, ITGA11, LAMA2, ITGA9, ACTN4, ITGB7, CACNA2D4, PKP2, CTNNB1, ITGA10, ITGA1, CACNA1D, CACNB4, ITGA4, ITGB1, CACNB3, LEF1, TCF7, ITGB6, ITGB3, ITGB4, ITGAV, ITGA7, ITGA2, CDH2, TCF7L1, DSP, ITGA3",0.278189384787453,0.1438755557577,FALSE +"H460","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.56121,2,0.00326,1779,0.0953,"UGDH, ALDH9A1, ALDH3A2, ALDH1B1",2.48678239993206,1.02090709936167,TRUE +"H460","Input","KEGG_ASTHMA",-0.30735,-1.06,0.341,7286,0.617,"CD40LG, IL3, CCL11, IL5, IL4, IL10, PRG2, EPX, FCER1G, RNASE3, TNF, IL13",0.467245621007502,0.209714835966758,FALSE +"H460","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.33144,1.19,0.187,11222,0.333,"IFNA21, TPO, CD40, FAS, CD86, CD80, IFNA4, PRF1, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, IL2, CD28, GZMB, TSHR, FASLG, IL5, TSHB, IFNA13, IL4, CTLA4, IL10, CGA, IFNA8, IFNA1, IFNA5",0.728158393463501,0.47755576649368,FALSE +"H460","Input","KEGG_AXON_GUIDANCE",-0.37738,-1.32,0.124,15092,0.389,"PAK4, SEMA6A, SLIT3, SEMA4D, RASA1, EPHB6, PLXNB2, PLXNC1, PLXNA3, CXCR4, ITGB1, CDK5, PLXNA1, SRGAP1, NCK2, SEMA3F, PTK2, SLIT2, EFNB3, RND1, GNAI3, PPP3CB, GSK3B, SEMA4A, KRAS, SEMA3B, PAK6, ABLIM3, PAK2, CFL1, SEMA4B, PPP3CA, RAC1, NRAS, ROCK1, RAC2, EPHA1, MAPK3, SEMA4C, MAPK1, EFNB2, EPHB3, NRP1, CDC42, SRGAP3, SEMA7A, ARHGEF12, SEMA3C, NFAT5, PLXNB1, EPHB2, FYN",0.906578314837765,0.410050398674292,FALSE +"H460","Input","KEGG_BASAL_CELL_CARCINOMA",-0.33368,-1.16,0.244,12943,0.527,"WNT8B, WNT6, WNT16, PTCH1, PTCH2, HHIP, FZD1, WNT7A, WNT5B, CTNNB1, WNT4, AXIN2, APC2, STK36, WNT2B, WNT10A, LEF1, TCF7, FZD2, SUFU, APC, FZD6, GSK3B, WNT9A, BMP4, WNT7B, TCF7L1, DVL3",0.612610173661271,0.278189384787453,FALSE +"H460","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.21663,0.796,0.736,1987,0.786,"GTF2H2, GTF2E2, GTF2A2, TAF9, TAF9B, TAF5",0.133122185662501,0.104577453960592,FALSE +"H460","Input","KEGG_BASE_EXCISION_REPAIR",0.56649,2.02,0.0177,2985,0.0963,"NEIL3, APEX1, POLE3, PARP1, MPG, POLD2, NTHL1, POLE2, PARP2, LIG3, HMGB1, NEIL2, APEX2, LIG1, TDG, PCNA, SMUG1, UNG, POLE, POLD1",1.75202673363819,1.01637371287547,TRUE +"H460","Input","KEGG_BETA_ALANINE_METABOLISM",0.36169,1.32,0.138,1898,0.311,"ALDH9A1, SRM, ECHS1, ALDH3A2, AOC3, ALDH1B1, HADHA",0.860120913598763,0.507239610973163,FALSE +"H460","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29982,1.08,0.327,3570,0.436,"ELOVL6, HADHA, FADS1, ACOT2, SCD, HSD17B12, ACOT1, ACOT4, FADS2, HACD1",0.485452247339714,0.360513510731414,FALSE +"H460","Input","KEGG_BLADDER_CANCER",-0.42156,-1.47,0.0697,16325,0.434,"DAPK2, DAPK3, RAF1, KRAS, CDH1, MMP2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, DAPK1, VEGFA, VEGFB, THBS1",1.15676722190199,0.362510270487489,FALSE +"H460","Input","KEGG_BUTANOATE_METABOLISM",0.40645,1.45,0.0872,2010,0.235,"AKR1B10, PDHA1, ALDH9A1, L2HGDH, HADH, ECHS1, ALDH3A2, ALDH1B1, HADHA, ACAT1",1.05948351506743,0.628932137728264,FALSE +"H460","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.4405,-1.53,0.0568,15329,0.388,"DAPP1, RASGRP3, SYK, CD22, SOS1, LILRB3, RAF1, PPP3CB, GSK3B, KRAS, PIK3CD, JUN, PIK3R3, PPP3CA, RAC1, AKT2, NRAS, RELA, CD72, NFKBIE, RAC2, MAPK3, IFITM1, MAPK1, SOS2, NFAT5, BCL10, PIK3CA",1.24565166428898,0.411168274405793,FALSE +"H460","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.20838,0.75,0.815,1786,0.844,"PDE1A, P2RX5, SLC25A6, VDAC1, SLC25A5, ADCY7, PHKA1, VDAC2, TBXA2R, PDE1C, NTSR1, CALM1, PTK2B, PLCB1, P2RX6, PPID, ITPR1, ADCY3, PRKX, PHKB, ATP2B1, BST1",0.0888423912600234,0.073657553374345,FALSE +"H460","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.25388,0.897,0.52,3067,0.66,"CACNA2D3, UQCRC2, TPM3, COX7C, COX5A, COX7B, UQCRQ, COX5B, CACNB2, UQCRHL, ATP1B3, COX6A1, COX6B1, RYR2, UQCRH",0.283996656365201,0.180456064458131,FALSE +"H460","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.19249,0.688,0.916,734,0.934,"CD226, MPZ, NRCAM, CNTN1",0.0381045263321496,0.0296531237699066,FALSE +"H460","Input","KEGG_CELL_CYCLE",0.26094,0.972,0.452,3732,0.572,"YWHAE, GADD45G, ANAPC1, SMAD2, ANAPC5, MCM6, ANAPC7, E2F4, BUB3, CDC25A, SMC1A, YWHAG, PTTG1, PLK1, ORC1, CDC26, MCM7, CCNB1, MCM4, CCNH, BUB1, PKMYT1, SKP2, BUB1B, CUL1, ORC2, STAG2, CDK1, PCNA, SFN, ORC6, CDK7, E2F2, MYC, CDC45, CDC6, SMC3, ORC5, CDC25B, MAD2L1, CHEK2, CCND3, ESPL1, CDC23, ANAPC2, CCNA2, ORC4, CDC7, ANAPC11, CCNB2",0.344861565188618,0.242603971206976,FALSE +"H460","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.26526,-0.921,0.526,13226,0.725,"ADCY4, WASL, GNG3, VAV3, ROCK2, DOCK2, CXCL12, GRK4, PIK3CB, VAV1, XCL1, PRKCD, PRKCZ, NFKBIA, PIK3R1, CXCR6, ARRB1, GRK3, ADCY5, CCL26, JAK2, PXN, RASGRP2, CCL5, GNB1, GNG7, CX3CL1, CXCR4, CCL2, GNG2, GSK3A, SOS1, GNG4, SHC2, PTK2, TIAM1, RAF1, GNAI3, GNG5, GSK3B, CRKL, KRAS, PIK3CD, CCL28, PIK3R3, GRK5, RAC1, PRKACA, PREX1, AKT2, NRAS, RELA, BRAF, ROCK1, RAC2, MAPK3, MAPK1, CDC42, RAP1A, ADCY6, SOS2, BCAR1, TIAM2, STAT3, STAT2, PIK3CA, FOXO3",0.279014255846261,0.139661993429006,FALSE +"H460","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.50074,-1.75,0.023,16534,0.375,"SHC2, RUNX1, RAF1, STAT5A, CRKL, KRAS, PIK3CD, PIK3R3, AKT2, NRAS, RELA, BRAF, MAPK3, CBLB, MAPK1, CDKN2A, SMAD3, CBL, MECOM, BCL2L1, GAB2, TGFBR2, SOS2, HDAC1, PIK3CA, CDKN1B",1.63827216398241,0.425968732272281,FALSE +"H460","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.55384,-1.93,0.0149,17307,0.764,"NR1D1, CSNK1E, ARNTL, PER3, CRY2",1.82681373158773,0.11690664142431,FALSE +"H460","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.64971,2.28,0.00817,3190,0.059,"FH, PDHA1, IDH3A, CS, SUCLG1, DLD, DLAT, MDH2, DLST, IDH1, IDH3B, IDH3G, ACLY, SDHC, SDHB, OGDH, ACO2, PDHB, SDHD",2.08777794346758,1.22914798835786,TRUE +"H460","Input","KEGG_COLORECTAL_CANCER",-0.40113,-1.4,0.0999,16075,0.397,"LEF1, TCF7, MAPK10, APC, RAF1, GSK3B, KRAS, PIK3CD, JUN, PIK3R3, RAC1, AKT2, BRAF, RAC2, MAPK3, MAPK1, TCF7L1, SMAD3, MAPK8, TGFBR2, PIK3CA",1.00043451177402,0.401209493236885,FALSE +"H460","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.23859,-0.839,0.671,13582,0.823,"SERPINA5, VWF, C3, C3AR1, MASP2, C4BPB, F8, SERPINF2, C2, BDKRB1, C1R, CFI, SERPING1, SERPINE1, C4B, SERPINA1, F2R, BDKRB2, C4A, F3, C5, CFB, CD59",0.173277479831008,0.0846001647877302,FALSE +"H460","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.43015,1.56,0.0642,3562,0.211,"GOT2, AHCY, SRM, AHCYL2, MAT2A, LDHA, ENOPH1, LDHB, DNMT1, GOT1, MTAP, CTH, MTR, SMS, AHCYL1",1.19246497193115,0.675717544702307,FALSE +"H460","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.1737,0.61,0.948,1310,0.99,"TNFRSF8, IL18RAP, CXCL5, OSM, FLT4, IL18R1, CD70, CXCL1, IFNA21, EGF, CSF2RA, PF4V1, TNFSF9, IL22RA1, EDA2R, TNFRSF10A, CXCL8, IL6, CXCL2",0.0231916626619338,0.00436480540245009,FALSE +"H460","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.28,1.02,0.367,3016,0.512,"POLR3K, POLR3G, IFNA21, IKBKG, TREX1, IL6, POLR3B, CHUK, POLR3D, POLR3GL, POLR3A, TBK1, ADAR",0.435333935747911,0.290730039024169,FALSE +"H460","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.19571,-0.676,0.924,10525,0.983,"CACNB1, CACNG8, MYL3, CACNG1, ACTC1, CACNA2D2, ADCY2, TNNI3, IGF1, MYL2, SGCG, CACNG6, SGCA, DAG1, SGCD, ITGB8, CACNG7, ITGA11, TNF, LAMA2, ITGA9, ADCY4, ITGB7, CACNA2D4, ADCY5, TNNT2, ITGA10, ITGA1, TPM4, CACNA1D, CACNB4, ITGA4, ITGB1, CACNB3, TNNC1, ITGB6, ITGB3, ITGB4, ITGAV, ITGA7, PRKACA, ITGA2, TPM1, ITGA3, ADCY6",0.0343280287798933,0.00744648216786438,FALSE +"H460","Input","KEGG_DNA_REPLICATION",0.66538,2.45,0,3867,0.0761,"RNASEH1, POLE3, PRIM1, MCM6, RFC2, POLA1, POLD2, RFC5, RPA4, POLE2, SSBP1, MCM7, MCM4, LIG1, PCNA, DNA2, RFC3, RPA2, POLE, POLD1, FEN1, RNASEH2A, RPA1, MCM5",Inf,1.11861534322943,TRUE +"H460","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.44443,-1.55,0.0634,12777,0.387,"PIWIL2, NOTCH4, ETV7, ETS1, EGFR, SPIRE1, NOTCH2, SOS1, PIWIL4, KRAS, ETS2, MAPK3, MAPK1, SOS2, ETV6",1.19791074211827,0.412289034981089,FALSE +"H460","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.25493,0.891,0.522,2218,0.655,"ALDH3A1, GSTM1, GSTM3, GSTO2, MGST1, ALDH3B1, GSTM4, GSTO1, MGST2",0.282329496997738,0.183758700008217,FALSE +"H460","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.24597,0.892,0.584,2401,0.662,"UCK2, IMPDH1, CES2, HPRT1, IMPDH2, CES1, ITPA",0.233587152887601,0.1791420105603,FALSE +"H460","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.2311,0.835,0.635,255,0.744,"COL4A6, TNXB, LAMC3, LAMA1, SPP1, COL5A2",0.197226274708024,0.128427064454121,FALSE +"H460","Input","KEGG_ENDOCYTOSIS",-0.39122,-1.37,0.105,13552,0.412,"GRK4, MDM2, AP2A1, SMAP2, VPS37C, PLD2, KIT, IL2RG, PDGFRA, USP8, SH3GL3, CSF1R, EGFR, PRKCZ, ARRB1, GRK3, DNM3, ACAP1, STAM, SH3GL1, DNM1, STAM2, ARAP2, CHMP2A, EPN3, AGAP2, VPS36, CHMP3, CBLC, CXCR4, RAB11B, VTA1, CLTCL1, SH3GLB2, VPS4B, AP2A2, SMURF1, RAB11FIP1, RAB11FIP4, PIP5K1C, FGFR2, F2R, NEDD4L, SMAP1, ASAP1, PDCD6IP, RAB11A, DNM1L, ADRB2, PARD6A, AP2M1, CHMP5, TSG101, ARF6, GRK5, CBLB, CDC42, CHMP2B, ARFGAP3, ERBB3, ACAP2, PSD4, CBL, DAB2, PARD6B, CHMP4B, DNM2, ARAP1, ITCH, VPS37B, EHD2, TRAF6, RAB22A, ARFGAP2, RAB5A, PRKCI, SH3GLB1, SMURF2, VPS28, EPS15, RAB5B",0.978810700930062,0.385102783966865,FALSE +"H460","Input","KEGG_ENDOMETRIAL_CANCER",-0.44705,-1.55,0.0545,14135,0.387,"EGFR, PIK3R1, CTNNB1, ERBB2, CCND1, AXIN2, APC2, LEF1, TCF7, SOS1, APC, RAF1, GSK3B, KRAS, PIK3CD, CDH1, PIK3R3, AKT2, NRAS, BRAF, MAPK3, MAPK1, TCF7L1, ILK, SOS2, PIK3CA, FOXO3",1.26360349772336,0.412289034981089,FALSE +"H460","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.26959,-0.93,0.531,13744,0.727,"PTPRZ1, IGSF5, EGFR, JAM2, NFKBIA, ATP6V1G2, ADAM10, CCL5, ATP6V1B2, MAPK11, F11R, PLCG1, MAPK10, ATP6V1A, HBEGF, MAPK13, ATP6V1E1, JUN, RAC1, ATP6V1C1, RELA, CDC42, MAPK14, MAPK8, ATP6V1H",0.274905478918531,0.138465589140962,FALSE +"H460","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.39252,-1.35,0.12,16073,0.413,"PLCG1, SOS1, MAPK10, NCK2, SHC2, PTK2, RAF1, BTC, STAT5A, GSK3B, CRKL, KRAS, PIK3CD, PAK6, HBEGF, PAK2, JUN, RPS6KB2, PIK3R3, AKT2, NRAS, BRAF, MAPK3, CBLB, MAPK1, ERBB3, TGFA, CBL, GAB1, MAPK8, SOS2, PIK3CA, CDKN1B",0.920818753952375,0.384049948343599,FALSE +"H460","Input","KEGG_ETHER_LIPID_METABOLISM",0.23702,0.842,0.635,1308,0.738,"PLA2G7, PLA2G4A, CHPT1",0.197226274708024,0.131943638176958,FALSE +"H460","Input","KEGG_FATTY_ACID_METABOLISM",0.30319,1.09,0.282,2664,0.428,"ALDH9A1, HADH, ECHS1, ALDH3A2, ACADSB, ALDH1B1, HADHA, ACAT1, ACAA2, ECI2, ACADS",0.549750891680639,0.368556230986828,FALSE +"H460","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.39513,-1.37,0.117,15701,0.412,"SYK, MAPK11, PLCG1, SOS1, MAPK10, PRKCE, RAF1, KRAS, PIK3CD, MAPK13, PIK3R3, RAC1, AKT2, NRAS, RAC2, MAPK3, MAPK1, MAPK14, PLA2G6, GAB2, MAPK8, SOS2, FYN, PIK3CA",0.931814138253838,0.385102783966865,FALSE +"H460","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.41854,-1.46,0.0808,13117,0.377,"LIMK2, PLA2G4F, WASL, AMPH, FCGR1A, VAV3, DOCK2, ARPC3, LAT, PIK3CB, VAV1, PLD2, SPHK1, PRKCD, PRKCG, PIK3R1, DNM3, SPHK2, DNM1, SYK, VASP, PLCG1, PLPP3, PIP5K1C, PRKCE, RAF1, ASAP1, DNM1L, CRKL, PIK3CD, CFL1, ARF6, RPS6KB2, PIK3R3, RAC1, AKT2, RAC2, MAPK3, MARCKSL1, MAPK1, CDC42, WASF2, PLA2G6, DNM2, GAB2, GSN, MARCKS, PIK3CA",1.09258863922541,0.423658649794207,FALSE +"H460","Input","KEGG_FOCAL_ADHESION",-0.30502,-1.06,0.354,13444,0.617,"VAV3, XIAP, ROCK2, THBS4, PGF, VWF, ACTN4, PIK3CB, VAV1, ITGB7, PDGFRA, PRKCG, COL5A1, LAMB3, THBS2, EGFR, PDGFA, PIK3R1, CTNNB1, ERBB2, CCND2, CCND1, ITGA10, ITGA1, PXN, LAMA3, MYLPF, CHAD, MYLK2, COL1A2, PAK4, PDGFC, ITGA4, RASGRF1, PPP1CA, PDGFD, ITGB1, VASP, COL11A2, SOS1, MYL9, ITGB6, ITGB3, LAMC2, PIP5K1C, MAPK10, COL6A2, SHC2, ITGB4, PTK2, FLNC, RAF1, ITGAV, ITGA7, LAMA4, MYL12A, GSK3B, CRKL, MYL12B, PIK3CD, BIRC3, PAK6, PARVA, PAK2, JUN, PIK3R3, RAC1, PPP1CB, ITGA2, AKT2, BRAF, ROCK1, RAC2, ARHGAP35, MAPK3, BIRC2, MAPK1, CDC42, VEGFA, TNC, PDGFB, ILK, ARHGAP5, MYLK, RAP1A, ITGA3, VEGFB, MAPK8, THBS1, TLN2, SOS2, BCAR1, FYN, PIK3CA",0.450996737974212,0.209714835966758,FALSE +"H460","Input","KEGG_FOLATE_BIOSYNTHESIS",0.39893,1.4,0.123,3512,0.256,"SPR, QDPR, PTS, DHFR",0.910094888560602,0.59176003468815,FALSE +"H460","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.40984,1.52,0.0712,4560,0.21,"AKR1B10, SORD, ALDOA, PFKM, PMM2, PFKP, PHPT1, KHK, AKR1B1, PFKL, ALDOC, HK1, HK2, MTMR2, TPI1, GMPPB, GMDS",1.14752000636314,0.677780705266081,FALSE +"H460","Input","KEGG_GALACTOSE_METABOLISM",0.3813,1.35,0.115,3880,0.289,"GLA, PFKM, GALK2, PFKP, G6PC2, AKR1B1, PFKL, PGM2, HK1, B4GALT2, HK2",0.939302159646388,0.539102157243452,FALSE +"H460","Input","KEGG_GAP_JUNCTION",0.18685,0.679,0.926,2889,0.936,"TUBB4A, EGF, ADCY7, SRC, TUBA1B, PLCB1, TUBB3, ITPR1, TUBA1A, ADCY3, PRKX, TUBA4A, CDK1, TUBAL3, GJA1, PRKCB, TUBB4B, TUBA1C",0.0333890133180656,0.0287241512618947,FALSE +"H460","Input","KEGG_GLIOMA",-0.33716,-1.16,0.25,13607,0.527,"MDM2, PIK3CB, E2F3, PDGFRA, PRKCG, EGFR, PDGFA, PIK3R1, CCND1, CALML6, PLCG1, SOS1, CALM3, SHC2, RAF1, KRAS, PIK3CD, PIK3R3, AKT2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, PDGFB, TGFA, SOS2, PIK3CA",0.602059991327962,0.278189384787453,FALSE +"H460","Input","KEGG_GLUTATHIONE_METABOLISM",0.53525,1.91,0.0224,2592,0.0995,"G6PD, GSTM1, PGD, GSR, ODC1, GGT1, GPX3, GCLM, GCLC, GSTM3, GSTO2, RRM2, SRM, LAP3, IDH1, MGST1, GSTM4, GSTO1, MGST2, GGCT, GSTM2",1.64975198166584,1.00217691925427,TRUE +"H460","Input","KEGG_GLYCEROLIPID_METABOLISM",0.27647,0.982,0.415,1938,0.563,"GLA, DGKD, DGKG, ALDH9A1, GPAT3, ALDH3A2, ALDH1B1, AGK",0.381951903287907,0.249491605148654,FALSE +"H460","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.237,-0.828,0.673,17294,0.823,"DGKA, CDS1, ETNK1, LPCAT2, MBOAT2, CDS2, DGKH, PLA2G6, CHKA, ETNK2, CHKB",0.171984935776023,0.0846001647877302,FALSE +"H460","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.22591,-0.801,0.747,13271,0.845,"GCAT, MAOB, PIPOX, DMGDH, SRR, SARDH, GNMT, AMT, GATM, PSPH",0.126679398184601,0.0731432910503077,FALSE +"H460","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.44645,1.62,0.0442,3658,0.185,"ALDH3A1, PDHA1, ALDH9A1, ALDOA, PFKM, PGAM1, DLD, GPI, ENO1, DLAT, ALDH3A2, PGK1, GAPDH, ALDH3B1, ALDH1B1, LDHA, PFKP, G6PC2, PGAM4, LDHB, PDHB, PKM, PFKL, ALDOC, PGM2, HK1",1.35457773065091,0.732828271596986,TRUE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.34649,1.24,0.178,1325,0.334,"CHSY3, CSGALNACT1, XYLT1, CHST15",0.749579997691106,0.476253533188435,FALSE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.34926,1.24,0.183,1267,0.334,"GLCE, HS6ST2, XYLT1, HS3ST3B1, HS3ST3A1",0.737548910269571,0.476253533188435,FALSE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.40258,-1.42,0.0952,15626,0.381,"B3GNT7, CHST2, FUT8, ST3GAL3, B4GALT4, B3GNT2",1.02136305161553,0.419075024324381,FALSE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.26732,0.959,0.456,1267,0.578,"HYAL1, HS3ST3B1, HS3ST3A1",0.341035157335565,0.238072161579471,FALSE +"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.30879,1.09,0.276,965,0.428,"ST6GALNAC4, B4GALNT1, ST3GAL1",0.559090917934782,0.368556230986828,FALSE +"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.33252,1.2,0.205,965,0.334,"GLA, ST3GAL1",0.688246138944246,0.476253533188435,FALSE +"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.41974,-1.46,0.0672,10585,0.377,"FUT5, FUT9, B4GAT1, FUT6, B3GALT2, B4GALT1, FUT4, B3GALT1, B3GNT4, ABO, FUT2, B3GNT5, FUT3, B3GALT5, ST8SIA1, B3GNT3, FUT1, ST3GAL6, ST3GAL3, B4GALT4, B3GNT2",1.17263072694617,0.423658649794207,FALSE +"H460","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.13232,0.472,1,3367,0.999,"PIGF, PIGB, DPM2, PIGH, PIGO, PIGW",0,0.000434511774017692,FALSE +"H460","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.59993,2.14,0.00583,2690,0.079,"MTHFD2L, CS, MTHFD1, PGP, MDH2, AFMID, MTHFD2, ACO2",2.23433144524099,1.10237290870956,TRUE +"H460","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.31803,-1.1,0.304,14994,0.609,"PLA2G12A, LHB, CACNA1D, GNRH1, MAP3K3, MAPK11, CALML6, GNRHR, SOS1, CALM3, MAPK10, RAF1, MAP3K4, KRAS, ITPR2, HBEGF, MAPK13, MMP2, JUN, PRKACA, MAP3K2, NRAS, MAPK3, MAPK1, CDC42, MAPK14, PLA2G6, MAPK8, ADCY6, SOS2, MAP3K1, MMP14",0.517126416391246,0.215382707367125,FALSE +"H460","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.34229,1.19,0.21,12576,0.333,"IL6, IL1A, FAS, CD86, CD80, PRF1, IFNG, KIR2DL1, KIR3DL2, IL2, CD28, KIR3DL1, KIR2DL3, GZMB, FASLG, KLRC1, KLRD1, IL1B, TNF",0.677780705266081,0.47755576649368,FALSE +"H460","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.30046,-1.04,0.377,12943,0.603,"WNT8B, WNT6, WNT16, PTCH1, PTCH2, HHIP, WNT7A, WNT5B, WNT4, BMP8A, CSNK1G2, FBXW11, STK36, WNT2B, WNT10A, BMP7, CSNK1G1, SUFU, CSNK1A1, GSK3B, RAB23, WNT9A, PRKACA, BMP4, CSNK1E, WNT7B",0.423658649794207,0.219682687859849,FALSE +"H460","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.26207,-0.917,0.518,11009,0.722,"CD19, GP5, CD3D, CD1D, CD33, CD38, CD7, IL11RA, CD36, CD44, THPO, CD34, IL1B, TNF, CD4, ITGAM, CD8A, IL1R2, GP1BA, FCGR1A, KIT, IL3RA, CSF1R, CSF2, ITGA1, ITGA4, CD9, ANPEP, CD22, IL7, IL7R, ITGB3, EPOR, IL11, MME, ITGA2, IL4R, CD59, FLT3LG, ITGA3",0.285670240254767,0.141462802430361,FALSE +"H460","Input","KEGG_HISTIDINE_METABOLISM",0.45304,1.6,0.059,1779,0.191,"ALDH3A1, BUD23, ALDH9A1, AMDHD1, ALDH3A2, ALDH3B1, ALDH1B1",1.22914798835786,0.718966632752272,FALSE +"H460","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.4106,1.49,0.0867,3688,0.212,"XRCC3, RAD51D, POLD2, RAD51B, RPA4, SSBP1, XRCC2, RAD51C, RPA2, POLD1, EME1, SEM1, RPA1",1.06198090252379,0.673664139071249,FALSE +"H460","Input","KEGG_HUNTINGTONS_DISEASE",0.40269,1.41,0.0976,3200,0.253,"ATP5F1B, NDUFB10, SLC25A6, CASP9, NDUFS2, ATP5MC1, VDAC1, UQCRC2, SLC25A5, ATP5MC3, POLR2C, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, POLR2D, VDAC2, NDUFB8, COX7C, SOD1, NDUFA5, POLR2L, NDUFA1, PLCB1, COX5A, PPID, TFAM, COX7B, POLR2J3, ITPR1, NDUFB3, UQCRQ, POLR2I, NDUFB1, COX5B, CASP8, NDUFS6, BDNF, SDHC, ATP5F1A, CREB1, UQCRHL, AP2B1, SDHB, ATP5F1C, NDUFS7, POLR2A, DNAL1, NDUFV3, ATP5MC2, ATP5F1D, NDUFS4, VDAC3, NDUFA7, NDUFC1, POLR2E, COX6A1, COX6B1, UQCRH, CYCS, SDHD, NDUFS5",1.01055018233331,0.596879478824182,FALSE +"H460","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.20689,-0.711,0.859,10525,0.96,"CACNB1, CACNG8, MYL3, CACNG1, ACTC1, CACNA2D2, TNNI3, IGF1, MYL2, SGCG, CACNG6, SGCA, DAG1, SGCD, ITGB8, CACNG7, ITGA11, TNF, LAMA2, ITGA9, ITGB7, CACNA2D4, TNNT2, ITGA10, ITGA1, TPM4, CACNA1D, CACNB4, ITGA4, ACE, ITGB1, PRKAA1, CACNB3, TNNC1, ITGB6, ITGB3, ITGB4, PRKAB1, ITGAV, ITGA7, ITGA2, TPM1, ITGA3",0.0660068361687577,0.0177287669604316,FALSE +"H460","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.38151,-1.3,0.156,16073,0.407,"PLCG1, PIP5K1C, PIP4K2A, INPP1, PIK3CD, INPPL1, INPP4B, INPP5J, SYNJ2, SYNJ1, ALDH6A1, PIK3C2A, PLCD1, INPP5B, ISYNA1, PIK3CA",0.806875401645538,0.39040559077478,FALSE +"H460","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.28842,-0.994,0.423,15520,0.654,"PPP1CA, INPP5K, CBLC, CALML6, PRKAA1, PTPRF, SOS1, TSC1, CALM3, MAPK10, SHC2, PRKAB1, RAF1, GSK3B, CRKL, SOCS1, KRAS, PIK3CD, LIPE, RPS6KB2, PIK3R3, PPP1CB, PRKACA, SORBS1, AKT2, NRAS, BRAF, MAPK3, CBLB, INSR, MKNK1, MAPK1, PTPN1, CBL, MAPK8, SOS2, PRKCI, PHKG1, PIK3CA",0.373659632624958,0.184422251675733,FALSE +"H460","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.1641,-0.576,0.994,13425,0.997,"TNFSF13, CXCL12, ITGB7, MADCAM1, ITGA4, CXCR4, CCL28",0.00261361560268669,0.00130484168834428,FALSE +"H460","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.30244,-1.07,0.308,13730,0.661,"PIK3CB, IL13, IL2RG, SPRED1, IL3RA, PIK3R1, CLCF1, CCND2, SPRED2, IL20RA, CSF2, CCND1, JAK2, IL20RB, STAM, CISH, STAM2, CBLC, IL23A, PIAS2, IFNAR2, TYK2, JAK1, IL7, IL7R, SPRY2, SOS1, IL10RB, EPOR, STAT5A, PIM1, SOCS5, IL11, SOCS1, PIK3CD, PIK3R3, IL6ST, AKT2, EP300, PIAS1, IFNGR2, CBLB, SPRY1, CREBBP, IFNGR1, IL4R, CBL, BCL2L1, SOS2, STAT3, IRF9, STAT2, PIK3CA",0.511449283499556,0.17979854051436,FALSE +"H460","Input","KEGG_LEISHMANIA_INFECTION",-0.4185,-1.46,0.0731,14672,0.377,"JAK2, NCF2, TLR2, TLR4, ITGA4, MAPK11, ITGB1, IRAK4, ITGB2, JAK1, MAPK13, JUN, RELA, MAP3K7, IFNGR2, MAPK3, MARCKSL1, MAPK1, IFNGR1, MAPK14, TRAF6, TAB2",1.13608262304214,0.423658649794207,FALSE +"H460","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.39162,-1.36,0.111,12132,0.413,"NCF1, PIK3R2, CLDN14, VAV2, PECAM1, CDH5, CLDN7, VCAM1, CLDN23, CLDN10, CLDN3, ITGAM, MMP9, CYBB, VAV3, ROCK2, CXCL12, ACTN4, PIK3CB, VAV1, PRKCG, JAM2, PIK3R1, CTNNB1, NCF2, PXN, CLDN9, MYLPF, THY1, ITGA4, CXCR4, MAPK11, ITGB1, ITGB2, F11R, VASP, PLCG1, MYL9, ESAM, SIPA1, PTK2, GNAI3, MYL12A, AFDN, MYL12B, PIK3CD, MAPK13, MMP2, PIK3R3, RAC1, RASSF5, ROCK1, RAC2, ARHGAP35, CTNND1, CDC42, ICAM1, MAPK14, ARHGAP5, RAP1A, OCLN, BCAR1, PIK3CA",0.954677021213343,0.384049948343599,FALSE +"H460","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.70752,2.48,0.0029,1898,0.102,"ALDH9A1, ECHS1, ALDH3A2, ALDH1B1, HADHA",2.53760200210104,0.991399828238082,TRUE +"H460","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.31205,1.21,0.185,292,0.335,"AKR1B10, PLA2G4A",0.732828271596986,0.474955192963155,FALSE +"H460","Input","KEGG_LONG_TERM_DEPRESSION",-0.20412,-0.702,0.867,14374,0.962,"GNAO1, CACNA1A, GNAQ, GNA13, PLA2G12A, PPP2CB, RAF1, GNAI3, PPP2R1A, KRAS, ITPR2, NRAS, BRAF, MAPK3, MAPK1, PLA2G6",0.0619809025237897,0.0168249279621871,FALSE +"H460","Input","KEGG_LONG_TERM_POTENTIATION",-0.31608,-1.12,0.274,16365,0.595,"CALM3, RAF1, PPP3CB, KRAS, ITPR2, PPP3CA, PPP1CB, PRKACA, NRAS, BRAF, EP300, MAPK3, RPS6KA2, MAPK1, CREBBP, RAP1A",0.562249437179612,0.22548303427145,FALSE +"H460","Input","KEGG_LYSINE_DEGRADATION",0.34846,1.26,0.194,3207,0.333,"ALDH9A1, SUV39H1, SETD7, AADAT, DLST, HADH, ECHS1, ALDH3A2, ALDH1B1, HADHA, ACAT1, OGDH, PLOD3, KMT5A, ASH1L, TMLHE",0.712198270069774,0.47755576649368,FALSE +"H460","Input","KEGG_LYSOSOME",-0.30037,-1.04,0.384,13756,0.603,"AP1S2, PLA2G15, AP3D1, M6PR, LAMP1, DNASE2, CTSA, MCOLN1, CTSK, LAPTM4A, IDUA, NPC1, ACP5, AP3M2, LAPTM5, LAMP2, LAMP3, GNPTG, CLTCL1, CTSO, HEXA, SUMF1, SCARB2, FUCA1, SMPD1, GLB1, SLC17A5, AP1G1, PSAP, AP3S1, ARSA, ACP2, HGSNAT, ENTPD4, CTSB, CTSS, CTSV, MAN2B1, MANBA, MFSD8, NEU1, ATP6V1H, NPC2, CTSH, CD164, SORT1, TPP1",0.415668775632469,0.219682687859849,FALSE +"H460","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.29299,-1.01,0.406,15225,0.642,"MAP3K11, RASA1, CACNA1D, CACNB4, RASGRP3, RASGRF1, HSPB1, MAP3K3, STK3, MAPK8IP2, FGF1, MAPK11, CACNB3, TAOK1, RRAS, SOS1, DUSP16, FGFR2, MAPK10, GADD45A, NTF4, ATF2, FLNC, RAF1, PTPRR, PPP3CB, MAP3K4, CRKL, MAP3K6, KRAS, PAK2, MAPK13, DUSP8, JUN, PPP3CA, DDIT3, RAC1, PRKACA, FGF11, MAP3K2, AKT2, NRAS, RELA, BRAF, MAP3K7, RAC2, MAPK3, PPM1A, RPS6KA2, MKNK1, MAPK1, CDC42, STMN1, MRAS, MAPKAPK2, NLK, MAPK14, PDGFB, MAPK8IP1, SRF, PLA2G6, MECOM, RAP1A, RASA2, MAPK8, TGFBR2, DUSP10, TRAF6, LAMTOR3, SOS2, MAP4K3, RELB, MAP3K1, PPM1B, TAB2",0.391473966422806,0.192464971931147,FALSE +"H460","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.21355,-0.739,0.83,11298,0.939,"PDX1, HNF1A, HNF4A, MAFA, GCK, FOXA3, HNF1B, NR5A2, FOXA2, HES1",0.0809219076239261,0.0273344077338891,FALSE +"H460","Input","KEGG_MELANOGENESIS",-0.26768,-0.933,0.511,12802,0.731,"CAMK2A, CREB3L2, WNT8B, WNT6, WNT16, ADCY4, FZD1, WNT7A, WNT5B, KIT, PRKCG, CREB3L4, CTNNB1, ADCY5, WNT4, GNAO1, GNAQ, CREB3, WNT2B, WNT10A, CALML6, LEF1, TCF7, CALM3, FZD2, CREB3L1, RAF1, FZD6, GNAI3, GSK3B, KRAS, WNT9A, PRKACA, NRAS, EP300, MAPK3, WNT7B, MAPK1, TCF7L1, CREBBP, ADCY6, DVL3",0.291579099865287,0.13608262304214,FALSE +"H460","Input","KEGG_MELANOMA",-0.27922,-0.965,0.452,11042,0.684,"FGF7, PIK3CG, FGF8, HGF, IGF1, MET, FGF22, AKT3, FGF17, FGF21, MITF, PIK3R2, FGF9, RB1, FGF18, MDM2, PIK3CB, E2F3, PDGFRA, EGFR, PDGFA, PIK3R1, CCND1, FGF5, PDGFC, PDGFD, FGF1, RAF1, KRAS, PIK3CD, CDH1, PIK3R3, FGF11, AKT2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, PDGFB, PIK3CA",0.344861565188618,0.164943898279884,FALSE +"H460","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.43887,1.53,0.0806,2218,0.21,"ALDH3A1, GSTM1, AKR1C2, AKR1C1, EPHX1, AKR1C3, CYP1B1, GSTM3, GSTO2, MGST1, ALDH3B1, GSTM4, GSTO1, MGST2",1.09366495819491,0.677780705266081,FALSE +"H460","Input","KEGG_MISMATCH_REPAIR",0.64874,2.32,0.00296,2985,0.0689,"EXO1, RFC2, POLD2, RFC5, RPA4, SSBP1, LIG1, PCNA, RFC3, RPA2, POLD1",2.52870828894106,1.16178077809237,TRUE +"H460","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.38178,-1.32,0.13,15817,0.389,"PRKAA1, TSC1, HIF1A, CAB39L, PIK3CD, RPS6KB2, PIK3R3, AKT2, CAB39, BRAF, MAPK3, RPS6KA2, MAPK1, VEGFA, VEGFB, RICTOR, PIK3CA",0.886056647693163,0.410050398674292,FALSE +"H460","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.30396,-1.05,0.336,12133,0.614,"PIK3R2, PPP3R2, SH2D1B, VAV2, CHP1, TNF, ULBP2, TNFRSF10D, NFATC2, KLRC3, ULBP1, KLRK1, VAV3, LCK, LAT, PIK3CB, VAV1, KLRC2, PRKCG, PIK3R1, RAET1L, CSF2, ICAM2, HCST, SYK, ITGB2, IFNAR2, PLCG1, SOS1, SHC2, RAF1, PPP3CB, KRAS, PIK3CD, TNFSF10, PIK3R3, PPP3CA, RAC1, NRAS, BRAF, IFNGR2, RAC2, MAPK3, MAPK1, IFNGR1, ICAM1, SH3BP2, SOS2, NFAT5, FYN, PIK3CA",0.473660722610156,0.211831628858832,FALSE +"H460","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.13822,-0.48,1,8151,0.999,"NPY2R, GABRG1, TAAR1, GRM6, MC2R, FSHR, CYSLTR2, HTR1E, CRHR2, PRL, GPR83, P2RY10, P2RY4, HTR4, GABRB3, HCRTR1, APLNR, GRM1, P2RX3, TSHB, ADRA1A, HCRTR2, CCKAR, GABRA4, GLP1R, GPR50, CALCR, S1PR4, HTR2B, RXFP1, TRHR, HRH3, NR3C1, CHRNA4, MC5R, DRD5, CHRNB2, CCKBR, FPR2, HTR1F, AVPR1A, FPR3, GABRB2, GRM7, P2RX7, AVPR1B, TACR3, THRA, HTR2A, NPY5R, GRM5, NMUR2, F2, P2RY8, ADCYAP1R1, CGA, CHRNB4, PTGER2, CYSLTR1, GRIA1, GABRG3, UTS2R, NPFFR1, CHRM2, GRM3, GRIN2C, P2RX1, LPAR6, GHSR, GRIN2D, P2RY13, GABRA2, GHRHR, GABRR1, SSTR2, GABRD, F2RL3, CHRNA1, CHRM1, GABRB1, GRIK3, CRHR1, ADORA3, PTGER3, GABRA5, PRSS1, GRIA3, MCHR2, CHRNA9, CHRNA3, CALCRL, MCHR1, PTGER1, GRM2, GRM8, P2RX2, GRIA2, EDNRB, GRID2, DRD1, CTSG, GRM4, HRH2, GRIA4, PRSS2, PTGIR, KISS1R, PLG, LPAR4, AGTR1, OPRD1, GRIN2A, GABRP, GRIN2B, SSTR1, P2RY14, PTH2R, ADRA2B, LPAR3, NPY1R, CNR1, DRD2, NPFFR2, ADRA2A, GABRG2, NPBWR1, TRPV1, FPR1, GRIK5, GRID1, HTR2C, PTGER4, OXTR, GALR3, PRLR, NMBR, GRIK4, GRIN1, GABRQ, HRH1, P2RY6, PTGFR, EDNRA, NPY4R, GRPR, GRIN3B, C3AR1, GPR156, ADRA1B, CHRNA10, CHRNE, GPR35, TACR2, CHRM4, GABRR2, LHB, GRIK2, GIPR, PRSS3, PTAFR, BDKRB1, S1PR1, HTR7, CHRM3, OPRL1, DRD4, GABRA3, P2RY2, GNRHR, ADORA2B, F2R, BDKRB2, VIPR1, P2RX4, ADORA2A, ADRB2, ADORA1, THRB, LPAR1, CHRNB1, P2RY11, F2RL1, S1PR2, LPAR2",0,0.000434511774017692,FALSE +"H460","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.40897,-1.43,0.0716,15435,0.385,"NGFR, MAP3K3, MAPK11, IRAK4, CALML6, PSEN1, PLCG1, SOS1, CALM3, MAPK10, FRS2, SHC2, NTF4, RAF1, GSK3B, CRKL, KRAS, PIK3CD, MAPK13, JUN, TP73, PIK3R3, RAC1, AKT2, NRAS, RELA, BRAF, NFKBIE, MAPK3, RPS6KA2, MAPK1, CDC42, MAPKAPK2, MAPK14, GAB1, ARHGDIB, RAP1A, MAPK8, TRAF6, YWHAZ, SOS2, MAP3K1, PIK3CA, SORT1, FOXO3",1.14508697769214,0.414539270491499,FALSE +"H460","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.35394,1.27,0.178,1786,0.329,"NAMPT, PNP, NT5M, NT5C, BST1",0.749579997691106,0.482804102050026,FALSE +"H460","Input","KEGG_NITROGEN_METABOLISM",0.29713,1.07,0.307,887,0.443,"CPS1, CA12",0.512861624522813,0.35359627377693,FALSE +"H460","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.30548,-1.06,0.327,16420,0.617,"MAPK10, TAB3, BIRC3, MAPK13, CASP1, RELA, MAP3K7, PYCARD, MAPK3, BIRC2, MAPK1, NLRP1, ERBIN, MAPK14, MAPK8, TRAF6, TAB2",0.485452247339714,0.209714835966758,FALSE +"H460","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.36945,-1.26,0.167,16071,0.423,"MRE11, LIG4, POLM, DCLRE1C",0.777283528852417,0.373659632624958,FALSE +"H460","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.4574,-1.59,0.0434,16073,0.437,"PLCG1, SOS1, FHIT, RAF1, KRAS, PIK3CD, PIK3R3, RASSF5, AKT2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, TGFA, SOS2, RXRB, PIK3CA, FOXO3",1.36251027048749,0.359518563029578,FALSE +"H460","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.4997,-1.75,0.0103,15409,0.375,"MAML2, NOTCH2, DLL1, RBPJ, MFNG, PSEN1, NUMB, KAT2B, DTX3L, DTX4, EP300, JAG1, MAML1, CREBBP, LFNG, RFNG, DVL3, HES1, CIR1, HDAC1, DTX2",1.98716277529483,0.425968732272281,FALSE +"H460","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.39236,1.41,0.104,3841,0.253,"GTF2H2, POLE3, RFC2, CUL4A, POLD2, RFC5, RPA4, POLE2, CCNH, ERCC8, LIG1, PCNA, RFC3, CDK7, RPA2, POLE, POLD1, XPA, GTF2H3, ERCC3, RAD23B, RPA1, XPC",0.98296666070122,0.596879478824182,FALSE +"H460","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.23208,-0.802,0.763,15016,0.854,"MAN2A2, ALG2, ALG8, MAN1C1, MGAT3, ALG6, ALG11, FUT8, DDOST, MGAT5B, MGAT4A, MAN1A1, MAN1A2",0.11747546204512,0.068542129310995,FALSE +"H460","Input","KEGG_OLFACTORY_TRANSDUCTION",0.2195,0.813,0.752,11747,0.77,"PDE1C, CALM1, ARRB2, ADCY3, PRKX, OR6A2, OR10AD1, OR10A2, GNAL, CAMK2D, OR1F1, CALM2, OR1L8, OR2AT4, PRKG2, OR2AG1, OR7C1, PRKACB, OR1Q1, OR6C6, OR52J3, OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR52D1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR13J1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, CLCA1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR2AE1, OR5AK2, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2H2, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, CNGA3, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR7D2, OR1B1, OR2L3, OR8D1, OR51E2, OR11H6, PDC, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5B21, OR5M11, OR13G1, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR51I1, OR5P3, OR52N2, OR8S1, OR9A2, OR51Q1, OR13D1, OR8D2, OR2T33, OR1J2, OR2S2, OR2A5, OR52H1, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, OR2T8, CALML3, OR4D1, OR2C1, OR8G1, CALML5, OR4F15, OR52B6, OR2A25, OR2D3, OR10H1, OR8A1, OR2B2, OR1K1, OR56B4, OR2J3, OR10A6, OR2A2, OR1J1, OR8G5, OR4F3, OR11H4, OR10A4, GUCY2D, OR51B4, OR13A1, OR6B2, OR2A12, OR2D2, OR10A3, OR2K2, PRKG1, CNGB1, OR13H1, OR2A14",0.123782159408358,0.113509274827518,FALSE +"H460","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.50003,1.78,0.0329,3512,0.126,"MTHFD2L, MTFMT, ATIC, MTHFD1, SHMT2, SHMT1, MTHFD2, MTHFS, MTR, DHFR",1.48280410205003,0.899629454882437,TRUE +"H460","Input","KEGG_OOCYTE_MEIOSIS",0.22185,0.804,0.722,2884,0.779,"YWHAE, ADCY7, ANAPC1, ANAPC5, CALM1, AR, ANAPC7, MAPK12, SMC1A, ITPR1, YWHAG, PTTG1, AURKA, ADCY3, PLK1, PRKX, CDC26, CCNB1, BUB1, PKMYT1, CUL1, CDK1, PPP2R5C, PPP2R1B, PPP2CA, PPP1CC, CAMK2D, SLK, SMC3",0.141462802430361,0.108462542327436,FALSE +"H460","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.55136,-1.92,0.00574,15891,0.4,"HEXA, FUCA1, GLB1, MAN2B2, MAN2B1, MANBA, NEU1",2.24108810760203,0.397940008672038,FALSE +"H460","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.46153,1.63,0.054,3200,0.187,"ATP5F1B, NDUFB10, NDUFS2, ATP5MC1, COX10, UQCRC2, ATP5MC3, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, COX15, ATP5ME, NDUFB8, COX7C, COX11, PPA1, NDUFA5, NDUFA1, COX5A, COX7B, NDUFB3, UQCRQ, NDUFB1, COX5B, NDUFS6, SDHC, ATP5F1A, UQCRHL, SDHB, ATP5F1C, NDUFS7, NDUFV3, ATP6V0D1, ATP5MC2, ATP5F1D, NDUFS4, ATP6V0E2, NDUFA7, NDUFC1, COX6A1, COX6B1, ATP6AP1, UQCRH, PPA2, SDHD, NDUFS5",1.26760624017703,0.728158393463501,FALSE +"H460","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.3466,1.2,0.231,1859,0.334,"GALNT16, GALNT13, GALNT14, ST3GAL1, C1GALT1C1, GALNT18, GALNT11",0.636388020107856,0.476253533188435,FALSE +"H460","Input","KEGG_P53_SIGNALING_PATHWAY",-0.25547,-0.88,0.592,13371,0.781,"ADGRB1, GADD45B, MDM2, CCNE2, DDB2, PMAIP1, CCND2, CCNE1, CCND1, SESN1, RRM2B, BBC3, SERPINE1, ATM, GADD45A, ZMAT3, APAF1, TP73, SESN2, CDKN2A, THBS1, SIAH1, CD82, CCNG2",0.22767829327708,0.1073489661227,FALSE +"H460","Input","KEGG_PANCREATIC_CANCER",-0.44057,-1.51,0.0665,16420,0.392,"MAPK10, RAF1, KRAS, PIK3CD, RALB, PIK3R3, RAC1, AKT2, RELA, BRAF, RAC2, MAPK3, MAPK1, CDKN2A, CDC42, VEGFA, SMAD3, TGFA, RALA, BCL2L1, VEGFB, MAPK8, TGFBR2, STAT3, PIK3CA",1.1771783546969,0.406713932979543,FALSE +"H460","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.38375,-1.32,0.134,10754,0.389,"DPYS, ENPP1, ENPP3, UPB1, VNN2, VNN1, PANK4, PANK3, PPCS, DPYD",0.872895201635192,0.410050398674292,FALSE +"H460","Input","KEGG_PARKINSONS_DISEASE",0.55018,1.99,0.00619,3200,0.0918,"PRKN, ATP5F1B, NDUFB10, SLC25A6, SNCA, CASP9, NDUFS2, ATP5MC1, VDAC1, UQCRC2, SLC25A5, ATP5MC3, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, UCHL1, VDAC2, NDUFB8, COX7C, NDUFA5, NDUFA1, COX5A, PPID, COX7B, NDUFB3, UQCRQ, NDUFB1, COX5B, HTRA2, NDUFS6, SDHC, ATP5F1A, UQCRHL, SDHB, ATP5F1C, NDUFS7, NDUFV3, UBB, ATP5MC2, ATP5F1D, NDUFS4, UBA1, VDAC3, NDUFA7, NDUFC1, COX6A1, COX6B1, PARK7, UQCRH, CYCS, SDHD, NDUFS5",2.20830935097988,1.03715731879876,TRUE +"H460","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.25758,0.921,0.471,4082,0.631,"NCL, ARHGEF2, TUBB4A, HCLS1, TUBA1B, CD14, TUBB3, TUBA1A, ARPC5L, TUBA4A, RHOA, TUBAL3, TUBB4B, TUBA1C, TUBB2B, EZR, TUBB2A, KRT18, ACTG1, ACTB, TUBA3D, TUBB6, ABL1",0.326979092871104,0.199970640755866,FALSE +"H460","Input","KEGG_PATHWAYS_IN_CANCER",-0.29691,-1.03,0.404,16043,0.612,"JAK1, FADD, PLCG1, LEF1, TCF7, SOS1, LAMC2, HIF1A, DAPK2, FGFR2, DAPK3, RARA, FZD2, MAPK10, NCOA4, PTK2, SUFU, RUNX1, ELOC, RBX1, APC, RAF1, ITGAV, FZD6, STAT5A, ARNT2, LAMA4, GSK3B, CRKL, KRAS, PIK3CD, BIRC3, CDH1, MMP2, WNT9A, CUL2, RALB, JUN, PIK3R3, CDKN2B, RAC1, RASSF5, FGF11, ITGA2, AKT2, NRAS, RELA, BRAF, BMP4, EP300, PIAS1, RAC2, MAPK3, BIRC2, CBLB, WNT7B, MAPK1, CDKN2A, CDC42, TCF7L1, CREBBP, DAPK1, VEGFA, EGLN2, SMAD3, PDGFB, TGFA, CBL, MECOM, RALA, FLT3LG, BCL2L1, ITGA3, VEGFB, MAPK8, TGFBR2, TRAF6, SOS2, DVL3, PPARD, HDAC1, STAT3, RXRB, PIK3CA, CDKN1B",0.393618634889395,0.213248577854439,FALSE +"H460","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.35682,1.28,0.142,1865,0.332,"UGDH, RPE, DCXR",0.847711655616944,0.478861916295964,FALSE +"H460","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.5638,2.03,0.0092,2290,0.109,"G6PD, PGD, TKT, PRPS1, TALDO1, ALDOA, PFKM, PRPS2, GPI, RPE, PFKP, RPIA",2.03621217265444,0.962573502059376,TRUE +"H460","Input","KEGG_PEROXISOME",-0.30624,-1.06,0.347,16111,0.617,"ACOX1, PEX7, XDH, PAOX, ACSL5, IDH2, PRDX5, PEX11G, PEX5, MLYCD, FAR2, ACOX3, ACOT8, PEX2, HMGCL, SCP2, CAT",0.459670525209126,0.209714835966758,FALSE +"H460","Input","KEGG_PHENYLALANINE_METABOLISM",0.56433,2.02,0.0132,1596,0.0963,"ALDH3A1, GOT2, HPD, PRDX6, AOC3, ALDH3B1",1.87942606879415,1.01637371287547,TRUE +"H460","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.31731,-1.1,0.295,15535,0.609,"INPP5K, CALML6, PLCG1, PIP5K1C, CALM3, PIP4K2A, INPP1, PIK3CD, ITPR2, PIK3R3, DGKA, INPPL1, INPP4B, INPP5J, CDS1, SYNJ2, SYNJ1, CDS2, DGKH, PIK3C2A, PLCD1, INPP5B, PIK3CA",0.530177984021837,0.215382707367125,FALSE +"H460","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.52074,1.87,0.0189,1873,0.108,"COX10, EARS2, HCCS, COX15, MMAB, BLVRB, FECH, BLVRA, UROD",1.72353819582676,0.96657624451305,TRUE +"H460","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.23813,-0.83,0.674,15730,0.83,"ACAA1, CYP27A1, ACOX1, ACSL5, SLC27A1, SORBS1, PPARA, CPT1B, ILK, ACOX3, SCP2, PPARD, RXRB",0.17134010346468,0.0809219076239261,FALSE +"H460","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.28596,0.998,0.428,1362,0.541,"SLC27A5, ACOX2, CYP39A1",0.368556230986828,0.266802734893431,FALSE +"H460","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.18797,-0.652,0.948,10646,0.975,"CD79A, ZAP70, CD19, CD3D, IGLL1, JAK3, CD4, CD8A, CIITA, LCK, RFXAP, BLNK, IL2RG, RAG1, IL7R, RFXANK, DCLRE1C",0.0231916626619338,0.0109953843014632,FALSE +"H460","Input","KEGG_PRION_DISEASES",0.30639,1.09,0.304,2117,0.428,"SOD1, HSPA5, IL6, LAMC1, NCAM2, HSPA1A, PRKX, STIP1",0.517126416391246,0.368556230986828,FALSE +"H460","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.27052,0.968,0.467,2295,0.571,"PDE3A, HSP90AA1, PDE3B, HSP90AB1, ADCY7, ANAPC1, ANAPC5, ANAPC7, CDC25A, MAPK12, ARAF, AKT1, ADCY3, PLK1, PRKX, CDC26, CCNB1, BUB1, PKMYT1, CDK1, MAPK9",0.330683119433888,0.243363891754152,FALSE +"H460","Input","KEGG_PROPANOATE_METABOLISM",0.45661,1.64,0.0531,2859,0.188,"ALDH9A1, ACSS3, SUCLG1, MCEE, ECHS1, ALDH3A2, ALDH1B1, HADHA, LDHA, ACAT1, ACACA, HIBCH, LDHB",1.27490547891853,0.72584215073632,FALSE +"H460","Input","KEGG_PROSTATE_CANCER",-0.33808,-1.16,0.235,13607,0.527,"MDM2, PIK3CB, E2F3, PDGFRA, CCNE2, CREB3L4, EGFR, NFKBIA, PDGFA, PIK3R1, CTNNB1, ERBB2, CCNE1, CCND1, CREB3, PDGFC, PDGFD, LEF1, TCF7, SOS1, FGFR2, CREB3L1, RAF1, GSK3B, KRAS, PIK3CD, PIK3R3, AKT2, NRAS, RELA, BRAF, EP300, MAPK3, MAPK1, TCF7L1, CREBBP, PDGFB, TGFA, SOS2, PIK3CA, CDKN1B",0.628932137728264,0.278189384787453,FALSE +"H460","Input","KEGG_PROTEASOME",0.66446,2.4,0.00311,3881,0.0724,"PSMB10, PSMB5, PSMA3, PSMD4, PSMD11, PSMC1, PSME3, PSMD14, PSMB6, PSMD1, PSMA6, PSMA4, PSMC5, PSMB4, POMP, PSMD7, PSMB7, PSMB3, PSMD12, PSMA7, PSMF1, PSMC6, PSMC2, PSMC4, PSMD3, PSMB8, SEM1, PSMB9, PSME2, PSMA1",2.50723961097316,1.14026143380285,TRUE +"H460","Input","KEGG_PROTEIN_EXPORT",0.21314,0.753,0.791,2667,0.848,"HSPA5, OXA1L, SRP68, SRP19, SPCS1, SEC11A",0.101823516502323,0.0716041477432862,FALSE +"H460","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.23093,-0.817,0.701,8788,0.835,"ATP1A2, ATP1B4, ATP1A4, CA4, MDH1, PCK1, GLS, FXYD2, ATP1B2, SLC38A3, GLUD1, AQP1, GLS2, PCK2, ATP1A1, SLC4A4, GLUD2",0.154281982033341,0.0783135245163979,FALSE +"H460","Input","KEGG_PURINE_METABOLISM",0.50449,1.82,0.0248,3031,0.121,"PDE1A, PDE3A, GDA, PDE10A, PNPT1, PDE7B, PDE4D, POLR3K, NPR1, PFAS, POLR3G, PAPSS2, POLR2C, PDE3B, PRPS1, POLE3, NME1, ADCY7, IMPDH1, PNP, NT5M, POLR2D, ATIC, PRIM1, PDE4B, NT5C, PDE8B, PDE1C, PRPS2, NME2, POLA1, RRM2, POLR2L, NME4, HPRT1, AK2, POLD2, DGUOK, POLR2J3, POLE2, IMPDH2, ADCY3, POLR3B, NME3, GUK1, POLR2I, POLR1B, ADSL, POLR3D, NUDT9, ENTPD6, POLR1E, PAICS, POLR2A, POLR3GL, ITPA, POLR3A, NME5, PPAT, POLR2E, POLE, POLD1, POLR1A, PDE4A",1.60554831917378,0.91721462968355,TRUE +"H460","Input","KEGG_PYRIMIDINE_METABOLISM",0.49961,1.79,0.0279,3137,0.127,"UCK2, PNPT1, POLR3K, POLR3G, POLR2C, TXNRD1, DHODH, POLE3, NME1, PNP, NT5M, POLR2D, PRIM1, NT5C, DTYMK, NME2, POLA1, RRM2, CAD, POLR2L, NME4, POLD2, CTPS1, POLR2J3, POLE2, POLR3B, NME3, POLR2I, POLR1B, POLR3D, ENTPD6, POLR1E, POLR2A, POLR3GL, ITPA, POLR3A, NME5, POLR2E, POLE, POLD1, POLR1A, TXNRD2, NT5C3A",1.5543957967264,0.896196279044043,TRUE +"H460","Input","KEGG_PYRUVATE_METABOLISM",0.53128,1.94,0.0213,3525,0.0943,"PDHA1, ALDH9A1, ME1, HAGHL, DLD, ACYP1, DLAT, ME2, MDH2, ALDH3A2, ALDH1B1, LDHA, ACAT1, ACACA, LDHB, AKR1B1, PDHB, PKM, LDHD, GRHPR",1.67162039656126,1.02548830726267,TRUE +"H460","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.33182,-1.16,0.246,13444,0.527,"VAV3, ROCK2, ARPC3, IQGAP2, ACTN4, PIK3CB, VAV1, ITGB7, PDGFRA, ITGAX, EGFR, PDGFA, PIK3R1, MYH9, RRAS2, FGF5, CHRM4, ITGA10, ITGA1, PXN, APC2, GNA13, MYLPF, MYLK2, PAK4, PDGFC, BDKRB1, ITGA4, CHRM3, PPP1CA, PDGFD, FGF1, ITGB1, ITGB2, RRAS, SOS1, MYL9, ITGB6, ITGB3, PIP5K1C, FGFR2, PIP4K2A, F2R, BDKRB2, ITGB4, PTK2, TIAM1, APC, SSH2, RAF1, ITGAV, ITGA7, MYL12A, CRKL, MYL12B, KRAS, PIK3CD, PAK6, PAK2, CFL1, BAIAP2, PIK3R3, RAC1, PPP1CB, FGF11, ITGA2, NRAS, BRAF, ROCK1, RAC2, ARHGAP35, MAPK3, ARHGEF7, BRK1, MAPK1, CDC42, MRAS, WASF2, PDGFB, ARHGEF12, MYLK, PFN4, ITGA3, SOS2, BCAR1, GSN, TIAM2, PIK3CA",0.609064892896621,0.278189384787453,FALSE +"H460","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.18999,-0.653,0.926,15784,0.985,"ATG12, PRKAA1, ATG5, GABARAP, GABARAPL2",0.0333890133180656,0.00656376950238827,FALSE +"H460","Input","KEGG_RENAL_CELL_CARCINOMA",-0.5016,-1.74,0.0206,16164,0.327,"SOS1, FLCN, HIF1A, ELOC, RBX1, RAF1, ARNT2, CRKL, KRAS, PIK3CD, PAK6, PAK2, CUL2, JUN, PIK3R3, RAC1, AKT2, NRAS, BRAF, EP300, MAPK3, MAPK1, CDC42, CREBBP, VEGFA, EGLN2, PDGFB, TGFA, GAB1, RAP1A, VEGFB, SOS2, PIK3CA",1.68613277963085,0.485452247339714,FALSE +"H460","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.25803,0.911,0.521,1166,0.642,"NLN, THOP1",0.283162276700476,0.192464971931147,FALSE +"H460","Input","KEGG_RETINOL_METABOLISM",-0.17394,-0.601,0.982,8288,0.998,"ADH1B, RDH8, UGT2B4, ADH4, UGT2B17, CYP1A2, ADH1A, AWAT2, UGT2A3, CYP2C19, UGT2B15, CYP2A7, CYP2C9, CYP26C1, CYP26B1, CYP2B6, CYP2C18, CYP3A4, ADH1C, CYP4A22, CYP2A6, CYP2C8, LRAT, CYP26A1, ADH6, DHRS9, UGT2B7, RDH5, RDH16, BCO1, RETSAT, RDH12, CYP3A5, ALDH1A2, DGAT2, DHRS3, RDH10, CYP1A1, DGAT1",0.00788851221305034,0.000869458712628891,FALSE +"H460","Input","KEGG_RIBOFLAVIN_METABOLISM",0.40671,1.49,0.0839,2443,0.212,"RFK, FLAD1, ACP1, PHPT1",1.0762380391713,0.673664139071249,FALSE +"H460","Input","KEGG_RIBOSOME",0.60489,2.14,0.0151,4206,0.079,"RPS4Y1, RPS4X, RPL31, RPL22L1, RPL36AL, RPS23, RPS26, RPL38, RPL13, RPLP1, RPL23A, RPS2, RPL26L1, RPL3, RPL7A, RPL17, RPLP0, RPS29, RPL36A, RPS9, RPL35, RPS7, RPL27, RPS15A, RPL19, RPL26, RPL9, RPS15, RPS24, RPL14, RPL10, RPS27A, RPL23, RPL13A, RPL39, RPS21, RPS17, RPL4, RPL37A, RPS12, RPS10, RPL6, RPL29, RPL37, RPL36, RPL41, RPS27, RPL10A, RPS25, RPSA, RPL34, RPS27L, RPL12",1.82102305270683,1.10237290870956,TRUE +"H460","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.30382,-1.06,0.348,15508,0.617,"AZI2, MAPK11, ATG12, IFIH1, TKFC, FADD, MAPK10, ATG5, MAPK13, RELA, IRF7, MAP3K7, MAPK14, ISG15, RIPK1, MAPK8, TRAF6, CYLD, MAP3K1",0.458420756053419,0.209714835966758,FALSE +"H460","Input","KEGG_RNA_DEGRADATION",0.3458,1.21,0.218,1464,0.335,"HSPD1, PNPT1, HSPA9, EDC4, EXOSC2, MTREX, EXOSC8, ENO1, WDR61, EXOSC7, EXOSC1, CNOT1, EXOSC9",0.661543506395395,0.474955192963155,FALSE +"H460","Input","KEGG_RNA_POLYMERASE",0.6485,2.29,0.00917,3017,0.0657,"POLR3K, POLR3G, POLR2C, POLR2D, POLR2L, POLR2J3, POLR3B, POLR2I, POLR1B, POLR3D, POLR1E, POLR2A, POLR3GL, POLR3A, POLR2E, POLR1A",2.03763066432998,1.18243463044022,TRUE +"H460","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.55174,1.94,0.0185,1843,0.0943,"SCLY, BUD23, MARS2, PAPSS2, GGT1, AHCY, AHCYL2, MAT2A",1.73282827159699,1.02548830726267,TRUE +"H460","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.27722,-0.963,0.484,15761,0.677,"ITGB1, TRAF1, PIAS2, LAMC2, PTK2, FHIT, ITGAV, LAMA4, PIK3CD, BIRC3, APAF1, PIK3R3, CDKN2B, ITGA2, AKT2, RELA, PIAS1, BIRC2, BCL2L1, ITGA3, TRAF6, RXRB, PIK3CA, CDKN1B",0.315154638355588,0.169411331314856,FALSE +"H460","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.43415,-1.55,0.0422,17822,0.387,"SNAP29, SNAP23, VAMP5, STX7, VAMP3, TSNARE1, BET1, STX3, STX12, STX5",1.37468754903833,0.412289034981089,FALSE +"H460","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.2283,-0.789,0.74,12862,0.858,"DEGS2, ASAH1, SGPP2, GAL3ST1, SPHK1, ACER3, SPHK2, KDSR, SMPD3, CERK, PLPP3, SMPD1, GLB1, SGPL1, ARSA, SPTLC2, UGCG, NEU1",0.130768280269024,0.0665127121512946,FALSE +"H460","Input","KEGG_SPLICEOSOME",0.43261,1.55,0.0581,3540,0.202,"SNRPF, HNRNPU, HNRNPM, SNRPB, PQBP1, HNRNPA3, PRPF4, HNRNPC, SRSF7, USP39, PRPF8, SNRPE, RBM8A, HSPA1A, HSPA8, HSPA1B, SNRPD3, PCBP1, HNRNPA1, ALYREF, SNRNP200, EIF4A3, SNRPG, SNRPA, SRSF1, CCDC12, PPIH, SRSF2, SRSF3, EFTUD2, SF3B4, U2AF2, SNRNP70, DDX46, ZMAT2, PHF5A, SNRPA1, SNRPD1, CTNNBL1, DDX23, LSM8, LSM6, HSPA6, TXNL4A, TCERG1, NCBP1, RBMX, HNRNPK, THOC3, PRPF6, LSM4, LSM7, PRPF40A, SRSF9, SNRPB2",1.23582386760967,0.694648630553376,FALSE +"H460","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.21776,0.781,0.735,2120,0.805,"UGDH, PYGB, GPI, PYGL, GBE1",0.133712660915805,0.0942041196321315,FALSE +"H460","Input","KEGG_STEROID_BIOSYNTHESIS",-0.27849,-0.972,0.458,13959,0.69,"SQLE, CEL, MSMO1, SC5D, DHCR24, TM7SF2",0.339134521996131,0.161150909262745,FALSE +"H460","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.2603,0.933,0.519,959,0.618,"AKR1C2, AKR1C1, AKR1C3, CYP1B1",0.284832642151542,0.209011524911184,FALSE +"H460","Input","KEGG_SULFUR_METABOLISM",0.36449,1.31,0.146,1528,0.314,"PAPSS2, SULT1A4, SULT1A1",0.835647144215563,0.503070351926785,FALSE +"H460","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.1358,0.485,1,1409,1,"SNRPB, SSB, SNRPD3",0,0,FALSE +"H460","Input","KEGG_TASTE_TRANSDUCTION",-0.20982,-0.72,0.852,13045,0.958,"TAS2R13, ADCY4, GNG3, TAS2R3, KCNB1, TAS2R20, CACNA1A, TAS2R10, GNB1, TAS2R4, TAS2R46, TAS2R31, SCNN1A, TAS2R14, TAS2R19, PRKACA, TAS2R5, ADCY6",0.0695604052332999,0.0186344909214556,FALSE +"H460","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.37443,-1.27,0.15,12475,0.43,"CDO1, GGT6, GGT5, ADO, CSAD, GGT7, GAD1",0.823908740944319,0.366531544420413,FALSE +"H460","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.33549,1.21,0.202,4809,0.335,"PMVK, PDSS1, ACAT1, FDPS, MVK, IDI1, ACAT2, GGPS1",0.694648630553376,0.474955192963155,FALSE +"H460","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.41502,-1.44,0.0852,15342,0.39,"BMP7, INHBE, INHBA, INHBB, PPP2CB, SMURF1, ID4, SP1, BMPR1B, ACVR1, RBX1, PPP2R1A, ACVR2B, RPS6KB2, CDKN2B, BMP4, EP300, ROCK1, RBL2, MAPK3, MAPK1, ACVR2A, CREBBP, SMAD3, LTBP1, THBS1, TGFBR2, ZFYVE9, SMAD7, BMPR2, SMURF2",1.0695604052333,0.408935392973501,FALSE +"H460","Input","KEGG_THYROID_CANCER",-0.46805,-1.65,0.0416,14209,0.374,"CTNNB1, CCND1, TFG, LEF1, TCF7, NCOA4, KRAS, CDH1, NRAS, BRAF, MAPK3, MAPK1, TCF7L1, RXRB",1.38090666937326,0.42712839779952,FALSE +"H460","Input","KEGG_TIGHT_JUNCTION",-0.29923,-1.04,0.382,13637,0.603,"MYH7B, ACTN4, MAGI3, EXOC4, IGSF5, PRKCD, PRKCG, YES1, PRKCZ, JAM2, PPP2R2A, CTNNB1, MYH9, MAGI2, PRKCQ, RRAS2, PPP2R2B, CLDN9, MYLPF, LLGL1, AMOTL1, TJP3, PPP2CB, EPB41L2, F11R, RRAS, MYL9, CTTN, MYH3, PRKCE, VAPA, GNAI3, MYL12A, PARD6A, AFDN, MYL12B, PPP2R1A, KRAS, CRB3, TJAP1, AKT2, NRAS, CGN, CDC42, MRAS, PARD6B, MAGI1, OCLN, PRKCI, CSNK2B, CSNK2A1",0.417936637088291,0.219682687859849,FALSE +"H460","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.27974,-0.968,0.447,15735,0.688,"MAPK11, IRAK4, TLR5, LY96, IFNAR2, FADD, MAPK10, TICAM2, PIK3CD, MAPK13, JUN, PIK3R3, RAC1, AKT2, RELA, IRF7, MAP3K7, MAPK3, MAPK1, MAPK14, TOLLIP, RIPK1, MAPK8, TRAF6, PIK3CA, TAB2",0.349692476868064,0.162411561764489,FALSE +"H460","Input","KEGG_TRYPTOPHAN_METABOLISM",0.35466,1.28,0.161,2420,0.332,"KYNU, ALDH9A1, TDO2, CYP1B1, AADAT, HADH, ECHS1, ALDH3A2, AFMID, ALDH1B1, HADHA, ACAT1, OGDH",0.79317412396815,0.478861916295964,FALSE +"H460","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.37996,-1.32,0.12,11667,0.389,"ABCC8, CACNA1B, HK3, MAFA, GCK, PIK3R2, CACNA1G, KCNJ11, TNF, SLC2A4, PIK3CB, PRKCD, PRKCZ, PIK3R1, CACNA1A, CACNA1D, MAPK10, PRKCE, SOCS1, PIK3CD, PIK3R3, MAPK3, INSR, MAPK1, MAPK8, PIK3CA",0.920818753952375,0.410050398674292,FALSE +"H460","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.31748,1.15,0.25,1387,0.374,"HSPD1, PTPRN",0.602059991327962,0.42712839779952,FALSE +"H460","Input","KEGG_TYROSINE_METABOLISM",0.34995,1.24,0.182,2003,0.334,"ALDH3A1, GOT2, BUD23, HPD, AOC3, ALDH3B1, FAH",0.739928612014925,0.476253533188435,FALSE +"H460","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.36309,-1.25,0.16,16073,0.428,"PLCG1, SOS1, NCK2, RAF1, PPP3CB, GSK3B, KRAS, PIK3CD, PAK6, PAK2, MAPK13, JUN, PIK3R3, PPP3CA, AKT2, NRAS, RELA, MAP3K7, NFKBIE, MAPK3, CBLB, MAPK1, CDC42, MAPK14, CBL, DLG1, SOS2, NFAT5, BCL10, FYN, PIK3CA",0.795880017344075,0.368556230986828,FALSE +"H460","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.39165,-1.33,0.122,15969,0.429,"PIAS2, SMURF1, FZR1, FBXW8, TRIM37, UBE3B, UBE2B, CDC16, UBE2H, UBE2E3, NEDD4L, ELOC, RBX1, CDC34, HUWE1, UBE2E1, SOCS1, FBXO2, BIRC3, CUL5, CUL2, UBE2J1, TRIM32, PIAS1, BIRC2, CBLB, UBR5, UBE2R2, HERC3, FBXW7, UBA7, CBL, SYVN1, UBOX5, ITCH, RNF7, TRAF6, SIAH1, UBE2Q2, CUL7, MAP3K1, SMURF2, UBE2W",0.913640169325252,0.367542707815276,FALSE +"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.73972,2.7,0,1031,0.0613,"IARS2, PDHA1, LARS2",Inf,1.21253952548158,TRUE +"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.33712,1.22,0.175,3266,0.343,"HSD17B10, ALDH9A1, DLD, MCEE, HADH, ECHS1, ALDH3A2, ACADSB, ALDH1B1, HADHA, ACAT1, ACAA2, MCCC2, ACADS, HIBCH, IVD, OXCT1",0.756961951313706,0.464705879957229,FALSE +"H460","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.26289,-0.912,0.517,13226,0.722,"ADCY4, PRKCH, PLA2G10, ROCK2, EDNRA, ACTG2, PRKCD, PRKCG, ADCY5, NPR2, PPP1R14A, PRKCQ, ADRA1B, GNAQ, GNA13, PLA2G12A, MYLK2, CACNA1D, PPP1CA, KCNMB4, CALML6, RAMP1, ADORA2B, MYL9, CALM3, KCNMA1, PRKCE, RAF1, ADORA2A, ITPR2, PPP1CB, KCNMB3, PRKACA, BRAF, ROCK1, MAPK3, MYL6B, MAPK1, ARHGEF12, PLA2G6, MYLK, ADCY6",0.286509456906058,0.141462802430361,FALSE +"H460","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.30143,-1.05,0.342,16619,0.614,"CREB3L1, RAB11A, PRKACA, DYNLL2, ARHGDIB, ADCY6, RAB5A, RAB5B",0.465973893943865,0.211831628858832,FALSE +"H460","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.34561,-1.19,0.223,16534,0.522,"SHC2, PTK2, RAF1, PPP3CB, KRAS, PIK3CD, MAPK13, PIK3R3, PPP3CA, RAC1, AKT2, NRAS, RAC2, MAPK3, MAPK1, CDC42, MAPKAPK2, VEGFA, MAPK14, PLA2G6, NFAT5, PIK3CA",0.651695136951839,0.282329496997738,FALSE +"H460","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.2502,-0.866,0.619,11911,0.799,"TJP2, ATP6V1G1, CFTR, ATP6V0D2, TJP1, ATP6V1D, ATP6V1C2, KDELR2, KCNQ1, PRKCG, SEC61A2, ATP6V1G2, ERO1A, SEC61A1, ATP6V1B2, KDELR3, KDELR1, PLCG1, ATP6V1A, ATP6V1E1, PRKACA, ATP6V1C1, ATP6V1H, SEC61G",0.208309350979882,0.0974532206860086,FALSE +"H460","Input","KEGG_VIRAL_MYOCARDITIS",-0.19476,-0.672,0.912,11242,0.977,"ABL2, SGCG, SGCA, DAG1, SGCD, MYH11, MYH15, LAMA2, EIF4G2, MYH7B, MYH9, CCND1, ITGB2, MYH3, EIF4G3, RAC1, RAC2, ICAM1, FYN",0.0400051616715838,0.0101054362812269,FALSE +"H460","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.36756,-1.26,0.162,16027,0.423,"PSEN1, LEF1, TCF7, FZD2, MAPK10, RBX1, CSNK1A1, APC, FZD6, PPP3CB, GSK3B, PPP2R1A, PRICKLE2, PORCN, WNT9A, JUN, VANGL2, PPP3CA, RAC1, PRKACA, EP300, MAP3K7, LRP6, ROCK1, FRAT1, RAC2, CSNK1E, PPP2R5E, WNT7B, TCF7L1, CREBBP, NLK, SMAD3, CTNNBIP1, MAPK8, SIAH1, NFAT5, CSNK2B, SENP2, DVL3, PPARD, TBL1XR1, CSNK2A1, PPP2R5B, DAAM1",0.790484985457369,0.373659632624958,FALSE +"H1299","Input","KEGG_ABC_TRANSPORTERS",-0.27792,-1.03,0.38,13038,0.664,"ABCA9, ABCA10, ABCC8, ABCB11, ABCC9, ABCA8, ABCB4, ABCA6, ABCC2, ABCG1, ABCA13, ABCA4, ABCA12, ABCB10, ABCB6, ABCC6, ABCG2, ABCD3, ABCA2, ABCA5, ABCC3, ABCC1",0.42021640338319,0.177831920631982,FALSE +"H1299","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.29126,-1.03,0.351,17481,0.664,"PPARD, IKBKB, STAT3, MAPK3, STAT5A, RARA, JUP, STAT5B, ARAF",0.454692883534176,0.177831920631982,FALSE +"H1299","Input","KEGG_ADHERENS_JUNCTION",-0.36884,-1.36,0.106,15231,0.356,"BAIAP2, LMO7, CREBBP, ACP1, RAC1, TGFBR1, SRC, PTPRB, ERBB2, IGF1R, CTNNA1, NECTIN4, CDH1, NLK, FER, CTNND1, SORBS1, EP300, MAPK3, NECTIN1, PTPN6, SNAI2, RAC2, PTPRM",0.97469413473523,0.448550002027125,FALSE +"H1299","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.1888,-0.694,0.899,17457,0.952,"SLC2A1, ADIPOR1, CPT1C, IKBKB, ACSL5, PPARA, STAT3, RXRA, IRS2",0.0462403082667712,0.0213630516155257,FALSE +"H1299","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.41181,-1.52,0.0708,14401,0.295,"GLS2, IL4I1, GLUD2, GLS, GFPT2, ACY3, GPT, DDO, GLUL, CPS1, ABAT, GFPT1, NIT2, ASS1",1.14996674231023,0.530177984021837,FALSE +"H1299","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.25321,0.866,0.618,2526,1,"PIK3CG, SCNN1G, SCNN1B, ATP1A3, PIK3CB, SGK1, PRKCG",0.209011524911184,0,FALSE +"H1299","Input","KEGG_ALLOGRAFT_REJECTION",0.22332,0.75,0.771,14847,1,"CD40, IL12A, IFNG, CD28, CD40LG, IL2, FASLG, IL12B, CD80, PRF1, FAS, IL4, IL10, CD86, GZMB, IL5, TNF",0.112945621949043,0,FALSE +"H1299","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.42904,-1.55,0.0665,10518,0.302,"PLA2G12B, PLA2G4B, PLA2G5, PLA2G2C, PLA2G2F, PLA2G4E, PLA2G2A, PLA2G3, PLA2G6, PLA2G10, ACOX1, FADS2, PLA2G4A, PLA2G12A",1.1771783546969,0.519993057042849,FALSE +"H1299","Input","KEGG_ALZHEIMERS_DISEASE",-0.19494,-0.714,0.845,14669,0.95,"UQCRQ, NDUFA4, NDUFA4L2, ITPR3, TNF, CYCS, LPL, GRIN2C, CACNA1D, CAPN1, ADAM10, NDUFC2, BID, CDK5R1, NDUFV1, CACNA1C, NDUFB8, ITPR1, ATP2A3, COX6B2, BACE1, IL1B, GNAQ, NDUFS4, GSK3B, LRP1, NDUFB4, PSEN2, ATP5F1C, PLCB2, IDE, CASP8, NDUFA3, NDUFA1, UQCRC2, SNCA, BACE2, APH1A, MAPK3, ATF6, FADD, CASP7, EIF2AK3, PPP3CB",0.0731432910503077,0.0222763947111523,FALSE +"H1299","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.41419,1.39,0.114,2864,0.585,"VARS2, DARS2, YARS2, RARS2, PSTK, FARSA, AARS2",0.943095148663527,0.23284413391782,FALSE +"H1299","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.37932,-1.35,0.131,16173,0.358,"GFPT2, GMPPA, HEXA, RENBP, PGM1, GALE, NPL, NANP, HK1, MPI, GFPT1, NAGK, CYB5R1, PMM2",0.882728704344236,0.446116973356126,FALSE +"H1299","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.24191,-0.885,0.605,17291,0.766,"RAB5A, MAPK13, CCS, MAP2K6, CASP1, CAT, PPP3CB, GPX1",0.218244625347531,0.115771230367396,FALSE +"H1299","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.23634,0.811,0.694,1584,1,"HSP90AA1, IFNA13, HSP90AB1, HSPA1L, HSPA8, NFYC, HSPA1A, HSPA1B",0.158640529545145,0,FALSE +"H1299","Input","KEGG_APOPTOSIS",-0.20417,-0.758,0.786,14618,0.958,"EXOG, CASP6, IL1R1, TNF, BAX, CYCS, ENDOD1, IL3RA, CAPN1, BID, IKBKG, IL1A, IL1B, CHUK, PRKACB, NGF, TNFRSF10B, CASP8, IKBKB, TNFSF10, XIAP, FADD, CASP10, CASP7, PPP3CB, MYD88",0.104577453960592,0.0186344909214556,FALSE +"H1299","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.46892,-1.66,0.049,11297,0.277,"PLA2G5, CBR1, PLA2G2C, PLA2G2F, ALOX15B, CYP2C19, CYP2C9, CYP2E1, PLA2G4E, CYP2B6, PLA2G2A, CYP4A22, CYP4F2, PLA2G3, CYP2C18, PLA2G6, ALOX15, CYP2J2, GGT6, GGT5, PTGES, PTGIS, PLA2G10, TBXAS1, CYP4F3, ALOX5, GPX2, LTC4S, PTGS1, GPX7, PTGS2, GPX3, GGT1, PLA2G4A, AKR1C3, PLA2G12A, GPX1",1.30980391997149,0.557520230935551,FALSE +"H1299","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.23539,-0.888,0.573,14340,0.777,"AOC1, GLS2, CKMT2, SAT2, CKMT1B, GLUD2, MAOB, GLS, GLUL, AGMAT, PRODH, PYCR2, ALDH18A1, CPS1, P4HA2, ALDH2, P4HA1, ASS1",0.24184537803261,0.109578981199086,FALSE +"H1299","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.28537,0.961,0.499,1220,1,"CACNG7, CACNB4, CACNG8, CACNG6, ITGA4, ITGA10, SLC8A1, ITGA6, CACNA2D1",0.30189945437661,0,FALSE +"H1299","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.43031,-1.54,0.0669,9337,0.299,"UGT2B10, UGT2B11, UGT2B17, ALDH1B1, UGT2B4, UGDH, ALDH9A1, UGT2A1, UGT2A3, UGT2B15, MIOX, UGT2B7, ALDH2",1.17457388223218,0.52432881167557,FALSE +"H1299","Input","KEGG_ASTHMA",0.2233,0.76,0.804,14847,1,"CD40, EPX, IL13, IL9, MS4A2, FCER1A, CD40LG, IL3, CCL11, IL4, IL10, PRG2, RNASE3, FCER1G, IL5, TNF",0.0947439512515487,0,FALSE +"H1299","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.22689,0.783,0.741,1138,1,"IFNA13, CD40",0.130181792020672,0,FALSE +"H1299","Input","KEGG_AXON_GUIDANCE",-0.40171,-1.49,0.0608,15000,0.27,"EFNB1, ABLIM2, PLXNC1, SRGAP3, CXCL12, UNC5A, SEMA4D, EPHB1, RAC1, FES, EPHA6, SLIT2, NTNG1, EPHB6, NTN4, CXCR4, GSK3B, EFNA5, NFATC2, SEMA3A, EFNA3, SEMA5A, EPHA1, EPHA4, EFNA1, PAK6, NRP1, EPHB2, EPHB3, SEMA7A, UNC5B, SEMA3F, ABLIM3, NCK2, PLXNB2, SEMA3B, L1CAM, LIMK2, MAPK3, RHOD, PLXNB1, RAC2, PLXNA2, PLXNB3, ABLIM1, PLXNA3, EFNA4, PPP3CB",1.21609642072727,0.568636235841013,FALSE +"H1299","Input","KEGG_BASAL_CELL_CARCINOMA",0.17837,0.608,0.972,4094,1,"WNT16, FZD9, APC2, WNT5B, DVL1, PTCH2, GLI1, SMO, WNT9A, STK36, FZD7, SHH, FZD1, DVL2",0.0123337350737254,0,FALSE +"H1299","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.34503,1.19,0.201,1899,0.843,"TBP, GTF2H4, TAF9, TAF9B, TAF6, TBPL1, TAF2, TAF5",0.696803942579511,0.0741724253752577,FALSE +"H1299","Input","KEGG_BASE_EXCISION_REPAIR",0.29973,1.03,0.365,2724,1,"XRCC1, POLE3, POLE2, NEIL2, UNG, POLD1, POLE",0.437707135543525,0,FALSE +"H1299","Input","KEGG_BETA_ALANINE_METABOLISM",0.18782,0.646,0.925,1279,1,"SMS, GAD1",0.0338582672609674,0,FALSE +"H1299","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29646,0.997,0.438,3901,1,"ELOVL2, ACOT7, ACOT2, ELOVL5, ACOX3, SCD",0.3585258894959,0,FALSE +"H1299","Input","KEGG_BLADDER_CANCER",-0.45861,-1.68,0.0351,16909,0.319,"ERBB2, DAPK2, FGFR3, EGF, CDH1, MMP2, CXCL8, MAPK3, VEGFA, VEGFB, DAPK1, ARAF",1.45469288353418,0.496209316942819,FALSE +"H1299","Input","KEGG_BUTANOATE_METABOLISM",-0.37555,-1.36,0.129,15843,0.356,"HMGCL, OXCT1, HADH, AKR1B10, AACS, HMGCS1, ACSM3, ABAT, ALDH2, BDH1, BDH2",0.889410289700751,0.448550002027125,FALSE +"H1299","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.25418,-0.927,0.506,15494,0.755,"RASGRP3, IKBKG, VAV1, RAC1, BLNK, SOS2, CD81, PLCG2, CHUK, GSK3B, DAPP1, NFATC2, CARD11, SYK, IKBKB, VAV3, MAPK3, PTPN6, IFITM1, RAC2, PPP3CB",0.295849483160201,0.122053048370812,FALSE +"H1299","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.22894,0.771,0.764,2526,1,"PTGER1, NTSR1, CACNA1A, P2RX5, CACNA1B, GRIN2D, PLCD4, ADORA2A, ADRA1B, TBXA2R, SLC8A1, TRPC1, CALM1, MYLK2, PHKA1, F2R, PLCB4, SLC25A31, NOS3, PHKG2, ADORA2B, PRKCG",0.11690664142431,0,FALSE +"H1299","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.41512,1.42,0.1,2224,0.679,"COX7B2, CACNG7, CACNB4, CACNG8, CACNG6, COX8C, SLC8A1, UQCRFS1, TPM2, CACNA2D1, CYC1, ATP1A3, UQCRB, COX6B1, COX4I1",1,0.168130225719498,FALSE +"H1299","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.2909,-1.07,0.317,13596,0.622,"CLDN14, CD22, ITGA9, ITGB7, CADM3, SELL, VCAM1, CDH5, CDH4, CLDN16, CLDN3, CD34, CLDN2, ITGB2, ESAM, ITGAV, NLGN4X, CD6, SDC3, CNTNAP2, NRXN2, CLDN9, CD8A, MPZ, CD276, F11R, NRXN3, CLDN11, VCAN, PDCD1LG2, SELPLG, NCAM1, MPZL1, CD58, NRCAM, CDH3, ICAM2, CLDN23, CLDN4, CD99, SDC2, CDH1, CLDN7, SDC1, CADM1, L1CAM, ITGB8, NECTIN1, ALCAM, PTPRM",0.498940737782249,0.206209615309181,FALSE +"H1299","Input","KEGG_CELL_CYCLE",0.47877,1.65,0.0365,4683,0.4,"CCNA1, E2F5, PRKDC, MCM7, BUB1, ANAPC4, DBF4, ESPL1, CDC20, CDKN2D, CCNB1, TTK, ANAPC13, MCM4, CDK7, PLK1, ORC3, RAD21, YWHAQ, MAD2L2, PTTG1, CCNB2, TGFB1, CDKN2A, CDC14A, E2F2, YWHAZ, MCM2, CDKN2B, E2F3, CDC25C, CDC25A, CDK6, ANAPC1, CCNA2, HDAC2, CHEK1, SMC1A, SMC1B, ATR, FZR1, MCM6, HDAC1, CDKN2C, ANAPC7, MCM5, ANAPC5, E2F4, GADD45B, CCNE2, TGFB3, ORC1, CCNH, CDC45, YWHAB, CUL1, E2F1, CDC7, PTTG2, CHEK2, MAD1L1, ZBTB17, ORC2",1.43770713554353,0.397940008672038,FALSE +"H1299","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.19879,-0.732,0.855,15596,0.968,"ADCY4, CXCL5, ADCY9, IKBKG, VAV1, RAC1, PRKCD, CXCL16, ADCY5, GRK7, CCL26, SHC3, CCL5, CXCR4, SOS2, CCL20, CHUK, GSK3B, PRKACB, ADCY6, CX3CL1, GRK2, CCL2, ADCY1, GNG2, ARRB1, PLCB2, STAT2, STAT1, IKBKB, VAV3, ADCY7, FOXO3, STAT3, RAP1A, CXCL8, MAPK3, RAC2, PTK2B, STAT5B",0.0680338852718274,0.0141246426916063,FALSE +"H1299","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.25172,0.858,0.624,3777,1,"PIK3CG, MECOM, TGFB1, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, HDAC2, CRK, CTBP1, PTPN11, CBL, AKT2, HDAC1, PIK3CD, NRAS, NFKB1, SHC1, RUNX1",0.204815410317576,0,FALSE +"H1299","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.37612,-1.41,0.101,16225,0.314,"CLOCK, BHLHE40, PER2, NR1D1, CRY2",0.995678626217357,0.503070351926785,FALSE +"H1299","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.38307,-1.41,0.0926,17118,0.314,"IDH3G, SUCLA2, FH, ACLY, MDH1, IDH1, PC, IDH2",1.03338901331807,0.503070351926785,FALSE +"H1299","Input","KEGG_COLORECTAL_CANCER",0.25852,0.887,0.585,5438,1,"PIK3CG, FOS, TGFB1, APC2, AKT1, APPL1, PIK3CB, AKT2, RAC3, PIK3CD, MSH3, BIRC5, MSH6, TGFB3, BAD, MLH1, RHOA, MSH2, MAPK9, PIK3R3, RAF1, MYC, JUN, MAPK10, SMAD4, CASP9",0.23284413391782,0,FALSE +"H1299","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.36445,-1.31,0.155,11642,0.375,"C5, F7, MASP1, FGA, F13A1, C6, PROS1, C4BPA, CR2, SERPIND1, FGG, FGB, F5, C5AR1, SERPING1, PLG, F8, A2M, C3AR1, VWF, SERPINA5, KLKB1, C4BPB, SERPINF2, TFPI, BDKRB1, PROC, CFI, PLAT, THBD, C2, BDKRB2, CD55, CFH, C3, C1S, CFB, F3, C1R, CD46",0.809668301829709,0.425968732272281,FALSE +"H1299","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.29925,1.02,0.369,5315,1,"CDO1, SMS, DNMT1, AHCY, CBS, LDHB, SRM, MTAP, ADI1, DNMT3A, APIP, TRDMT1, AMD1, AHCYL2",0.43297363384094,0,FALSE +"H1299","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.25288,-0.95,0.466,11532,0.732,"OSM, CX3CR1, IL10, IFNW1, CXCL9, CCL24, IL19, PF4, PDGFB, PPBP, IL12RB2, CCR9, IFNA21, CCL3L3, IL18RAP, IL1RAP, CCL25, TNFSF9, TNFSF4, IFNL2, LIF, IFNA8, IFNL3, IL10RB, CCL15, LIFR, IL2RA, CLCF1, IL23A, CCL3, TPO, IL2RB, LEPR, IL17B, IL13RA1, TNFRSF4, CCL22, EGFR, IFNA1, CCR3, IFNA5, CSF3, IFNL1, MET, KIT, IFNB1, CCR1, PRLR, KDR, EDAR, RELT, CXCL11, CCL17, TNFSF18, HGF, CXCL1, CCR7, CRLF2, FLT1, TNFSF14, CXCL3, CNTFR, IL20RA, IL12RB1, TSLP, IL5, TNFSF13B, IFNGR1, CXCL6, CXCL14, IL1R1, TNF, CXCL10, BMPR1A, IL21R, ACVRL1, IL3RA, IL2RG, IL24, IL17RB, IL7R, CXCL12, TNFSF15, PDGFRA, CD27, IL20RB, CXCL5, TNFRSF18, CSF2, CSF2RA, CSF1R, CXCL16, EDA2R, CCL26, IL1A, CCL5, IL1B, CXCR4, NGFR, IL22RA1, IL11, CCL20, TGFBR1, PDGFRB, IL1R2, TNFRSF11B, INHBE, TNFRSF10B, INHBB, CX3CL1, BMP2, IL15, CCL2, IFNLR1, IL6, EGF, INHBA, TNFRSF19, IL15RA, TNFSF10, TNFRSF21, TNFSF13, IL6R, CSF1, CXCL8, TNFSF12, IL18, VEGFA, TNFRSF14, KITLG, FLT3LG, VEGFB, PDGFA, LTBR",0.33161408331,0.135488918941608,FALSE +"H1299","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.30995,-1.12,0.263,15724,0.57,"IKBKG, AIM2, POLR3B, CCL5, IL1B, CHUK, IL6, IKBKB, PYCARD, POLR1D, CASP1, MAVS, IKBKE, IL18, TREX1",0.580044251510242,0.244125144327509,FALSE +"H1299","Input","KEGG_DILATED_CARDIOMYOPATHY",0.25915,0.893,0.593,1574,1,"CACNG7, CACNB4, CACNG8, CACNG6, ITGA4, ITGA10, SLC8A1, TPM2, ITGA6, CACNA2D1, TGFB1",0.226945306635737,0,FALSE +"H1299","Input","KEGG_DNA_REPLICATION",0.59819,2.02,0.00448,3534,0.184,"MCM7, RFC1, MCM4, POLA1, PRIM1, RPA2, POLE3, POLE2, MCM2, POLD1, POLE, RFC2, RNASEH2A, RNASEH1, PRIM2, RPA1, MCM6, RFC5, MCM5",2.34872198600186,0.735182176990464,TRUE +"H1299","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.2771,-1.01,0.383,16413,0.687,"SOS2, FMN2, NOTCH1, ETV7, ETS2, MAPK3",0.416801226031377,0.16304326294045,FALSE +"H1299","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.41269,-1.47,0.0811,9885,0.284,"UGT2B11, UGT2B17, GSTA3, CYP2A13, FMO2, UGT2B4, ADH7, ADH4, CYP1A2, FMO1, UGT2A1, UGT2A3, GSTM5, CYP2C19, UGT2B15, GSTP1, GSTA2, CYP2A7, GSTM3, FMO3, CYP2C9, CYP2E1, CYP2B6, CYP3A4, GSTA1, MAOA, ADH1C, GSTM4, CYP2C18, CYP2A6, GSTO1, CYP3A7, UGT2B7, GSTM1, MAOB, ALDH3B2, FMO5, MGST3, CYP3A5, MGST1, GSTZ1, ALDH1A3, CYP2D6, ALDH3A1, GSTO2, GSTT2, FMO4, MGST2",1.09097914578884,0.546681659952962,FALSE +"H1299","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.17863,-0.67,0.937,11225,0.964,"UGT2A1, CES5A, UPB1, UGT2A3, UGT2B15, CYP2A7, TYMP, DPYS, CYP3A4, CYP2A6, NAT2, TK2, CES1, CYP3A7, UPP1, UGT2B7, CES2, CYP3A5, CDA, NAT1",0.0282604091122217,0.0159229660971692,FALSE +"H1299","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.38238,-1.41,0.1,14594,0.314,"VTN, THBS2, ITGAV, VWF, CD36, COL5A3, SDC3, ITGA11, HSPG2, COL6A3, THBS1, ITGA1, COL1A2, COL3A1, COL4A4, CHAD, LAMA4, FN1, COL4A6, LAMA1, LAMC1, ITGB6, GP1BB, ITGB4, AGRN, TNC, COL5A2, SDC2, LAMB1, COL5A1, SV2A, LAMA3, SDC1, ITGB8, COL1A1, COL4A1, COL4A2",1,0.503070351926785,FALSE +"H1299","Input","KEGG_ENDOCYTOSIS",-0.22064,-0.799,0.703,15437,0.902,"VPS37C, PDGFRA, MDM2, ERBB3, AGAP2, PIP4K2B, PSD, CSF1R, NEDD4L, TFRC, RAB22A, GRK7, ARAP2, STAM, CXCR4, ARF6, SRC, EPS15, CHMP6, STAMBP, DNM1, GRK2, EPN3, CBLC, RAB5A, CHMP4B, IGF1R, LDLRAP1, ARRB1, ARFGAP2, FGFR3, CHMP2B, RAB11FIP1, ARAP1, EGF, RAB5B, FGFR2, RAB11FIP4, PARD6B, PARD6G, ACAP3, CBLB, TSG101, RAB5C, VPS25, PSD4, TRAF6",0.153044674980176,0.0447934624580583,FALSE +"H1299","Input","KEGG_ENDOMETRIAL_CANCER",-0.24859,-0.922,0.52,16413,0.758,"SOS2, GSK3B, ERBB2, PDPK1, CTNNA1, EGF, CDH1, FOXO3, MAPK3, ARAF",0.283996656365201,0.120330794367946,FALSE +"H1299","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.23971,-0.887,0.564,15427,0.77,"ADAM10, ATP6V0A1, IKBKG, ATP6V1E1, RAC1, ATP6V1A, ATP6V0A4, ATP6V1B2, CCL5, ATP6V1G2, F11R, PLCG2, CHUK, SRC, MAPK13, IKBKB, ATP6V1B1, ATP6AP1, ATP6V0E1, CXCL8",0.248720896016658,0.113509274827518,FALSE +"H1299","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.26719,-0.997,0.417,15648,0.695,"RPS6KB2, ERBB3, CAMK2B, SHC3, SOS2, NRG4, PLCG2, SRC, GSK3B, ERBB2, EREG, CBLC, BTC, PAK6, EGF, AREG, NCK2, GAB1, MAPK3, CBLB, STAT5A, STAT5B, ARAF",0.379863945026242,0.158015195409886,FALSE +"H1299","Input","KEGG_ETHER_LIPID_METABOLISM",-0.192,-0.688,0.91,16979,0.951,"LPCAT2, PLPP3, PLA2G4A, PLA2G12A",0.0409586076789064,0.0218194830625861,FALSE +"H1299","Input","KEGG_FATTY_ACID_METABOLISM",-0.21241,-0.79,0.749,13073,0.91,"ACSL6, CYP4A22, ADH1C, ACSL4, ECHS1, CPT2, CPT1B, EHHADH, ACSL1, ACOX1, ACAA1, HADHB, HADH, CPT1C, ACSL5, ALDH2",0.125518182300534,0.0409586076789064,FALSE +"H1299","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.18973,-0.698,0.92,13586,0.965,"PLA2G3, FCER1G, PLA2G6, GAB2, PRKCA, MAPK8, INPP5D, IL5, TNF, PLA2G10, CSF2, VAV1, RAC1, PRKCD, SOS2, PLCG2, PDPK1, SYK, MAPK13, VAV3, MAP2K6, PLA2G4A, MAPK3, RAC2, PLA2G12A",0.0362121726544447,0.0154726866562074,FALSE +"H1299","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.18159,0.625,0.956,4882,1,"PIK3CG, VASP, ARPC1A, DNM1L, PIKFYVE, ASAP1, AKT1, ARPC1B, PIK3CB, PLPP2, CRK, PRKCG, WASF1, AKT2, PLD2, MYO10, PIK3CD, CFL2, ASAP3, WASF2, PRKCE, ASAP2, GSN, ARPC5L, LIMK1, FCGR3A, WASF3, PIK3R3",0.0195421077238999,0,FALSE +"H1299","Input","KEGG_FOCAL_ADHESION",-0.20704,-0.761,0.796,15701,0.963,"COL6A3, VAV1, RAC1, THBS1, ITGA1, COL1A2, COL3A1, COL4A4, SHC3, SOS2, CHAD, SRC, GSK3B, PDGFRB, LAMA4, FN1, ERBB2, RASGRF1, COL4A6, LAMA1, LAMC1, PDPK1, ITGB6, ITGB4, IGF1R, PAK6, EGF, TNC, COL5A2, VAV3, LAMB1, COL5A1, LAMA3, XIAP, RAP1A, ITGB8, MAPK3, COL1A1, VEGFA, ARHGAP5, RAC2, VEGFB, COL4A1, COL4A2, PDGFA, PPP1CB",0.0990869322623309,0.0163737128754655,FALSE +"H1299","Input","KEGG_FOLATE_BIOSYNTHESIS",0.24073,0.828,0.681,4660,1,"GGH, SPR, DHFR, PTS",0.166852888087215,0,FALSE +"H1299","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.55088,-1.95,0.0205,15333,0.308,"FPGT, ALDOA, FBP1, PFKFB3, GMPPA, AKR1B10, PFKFB4, PFKFB2, MTMR6, HK1, MPI, ALDOC, PMM2",1.68824613894425,0.511449283499556,FALSE +"H1299","Input","KEGG_GALACTOSE_METABOLISM",-0.3003,-1.08,0.291,16980,0.612,"PGM1, GALE, GLB1, HK1, B4GALT1",0.536107011014093,0.213248577854439,FALSE +"H1299","Input","KEGG_GAP_JUNCTION",-0.26765,-0.979,0.431,14284,0.695,"PRKCA, GUCY1A1, DRD2, TUBAL3, ITPR3, HTR2C, PDGFRA, ADCY4, ADCY9, TUBA8, ITPR1, ADCY5, LPAR1, TUBA3D, GNAQ, SOS2, SRC, PDGFRB, PRKACB, ADCY6, ADCY1, PLCB2, EGF, ADCY7, GJA1, MAPK3, PDGFA, TUBA4A",0.365522729839268,0.158015195409886,FALSE +"H1299","Input","KEGG_GLIOMA",0.22609,0.785,0.755,3610,1,"PIK3CG, CALM1, MTOR, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, PRKCG, AKT2, PIK3CD, NRAS, SHC1",0.122053048370812,0,FALSE +"H1299","Input","KEGG_GLUTATHIONE_METABOLISM",-0.41264,-1.51,0.0595,16112,0.282,"GGCT, GPX2, GSR, MGST3, MGST1, GSTZ1, GCLC, GPX7, GSTO2, GSTT2, GPX3, GGT1, IDH1, G6PD, IDH2, MGST2, GPX1",1.22548303427145,0.549750891680639,FALSE +"H1299","Input","KEGG_GLYCEROLIPID_METABOLISM",0.21209,0.733,0.827,2239,1,"GPAT2, AGPAT1, GPAT3, DGAT2, DGKE, PLPP2",0.0824944904474534,0,FALSE +"H1299","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.23145,0.787,0.745,2728,1,"GPAT2, PEMT, AGPAT1, LYPLA1, GPAT3, CHPT1, ACHE, DGKE, PLPP2, ETNK1, PTDSS1, LPCAT3",0.127843727251707,0,FALSE +"H1299","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.21311,0.713,0.876,804,1,"GLDC, ALAS1",0.0574958938319193,0,FALSE +"H1299","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.2349,-0.85,0.652,15309,0.809,"PCK2, ALDH3B2, ALDOA, FBP1, ALDH1A3, LDHA, PGM1, ALDH3A1, HK1, ALDH2, ACSS1, ALDOC, AKR1A1",0.18575240426808,0.0920514783877277,FALSE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.18115,-0.665,0.945,14570,0.96,"B3GAT1, B3GAT3, CHPF, B4GALT7, XYLT1, CHST15",0.0245681914907371,0.0177287669604316,FALSE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.35545,-1.3,0.136,13971,0.37,"EXTL1, B3GAT1, B3GAT3, B4GALT7, EXT1, GLCE, XYLT1, HS6ST1, HS3ST1, HS6ST2, EXT2",0.866461091629782,0.431798275933005,FALSE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.57759,-2.1,0.00773,15489,0.299,"CHST1, CHST6, ST3GAL3, B3GNT7, B3GNT2, ST3GAL1, B4GALT4, B4GALT1",2.11182050608168,0.52432881167557,FALSE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.41674,-1.51,0.0653,16808,0.282,"HEXA, GLB1, IDUA, IDS, HGSNAT, NAGLU",1.18508681872493,0.549750891680639,FALSE +"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.33653,1.14,0.27,4284,0.871,"ST6GALNAC4, ST6GALNAC6, ST8SIA5, B4GALNT1, ST3GAL2, ST6GALNAC3, ST8SIA1",0.568636235841013,0.0599818449923368,FALSE +"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.52051,-1.9,0.012,16808,0.258,"HEXA, GBGT1, FUT2, ST3GAL1, FUT1, B3GALNT1",1.92081875395238,0.58838029403677,FALSE +"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.40077,-1.45,0.0889,15219,0.297,"B3GALT5, ST3GAL4, ABO, ST3GAL3, FUT3, B3GNT3, B3GNT2, FUT2, B4GALT4, FUT1, B4GALT1",1.05109823902979,0.527243550682788,FALSE +"H1299","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.27392,-1.01,0.391,14781,0.687,"PIGY, PIGK, PIGM, PIGQ, PIGC, PIGB, PIGV, PIGS",0.407823242604133,0.16304326294045,FALSE +"H1299","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.4312,1.45,0.0734,3418,0.679,"MDH2, MTHFD1L, MTHFD2L, MTHFD1, CS, GRHPR",1.13430394008393,0.168130225719498,FALSE +"H1299","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.24188,-0.867,0.597,14832,0.789,"ITPR3, PLA2G10, ATF4, CACNA1D, ADCY4, CACNA1C, ADCY9, ITPR1, PRKCD, CAMK2B, ADCY5, GNAQ, SOS2, SRC, PRKACB, ADCY6, ADCY1, MAPK13, PLCB2, MMP2, ADCY7, MAP2K6, PLA2G4A, MAPK3, PLA2G12A, MAP3K1, PTK2B",0.224025668870631,0.10292299679058,FALSE +"H1299","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.45297,-1.62,0.0408,8677,0.269,"IFNG, CD28, KIR2DL1, KIR3DL2, IL2, KIR3DL1, KIR2DL3, FASLG, CD80, PRF1, FAS, KLRC1, CD86, GZMB, TNF, IL1A, IL1B, IL6",1.38933983691012,0.570247719997592,FALSE +"H1299","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.20398,-0.715,0.852,16658,0.958,"GSK3B, PRKACB, WNT11, GAS1, BMP2, SUFU, GLI2, BMP4, WNT5A, BTRC, WNT7B",0.0695604052332999,0.0186344909214556,FALSE +"H1299","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.24664,-0.898,0.563,13245,0.764,"CD3D, THPO, CD7, CSF3, KIT, CD22, CD33, CD34, IL5, CD1D, IL1R1, TNF, IL3RA, CD36, IL7R, FCGR1A, CSF2, CD14, CSF2RA, CSF1R, TFRC, ITGA1, CD8A, IL1A, IL1B, IL11, IL1R2, GP1BB, IL6, CD55, IL6R, CSF1, KITLG, FLT3LG",0.249491605148654,0.11690664142431,FALSE +"H1299","Input","KEGG_HISTIDINE_METABOLISM",0.27812,0.959,0.471,397,1,"FTCD, BUD23",0.326979092871104,0,FALSE +"H1299","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.6082,2.05,0.00158,3832,0.243,"XRCC3, EME1, RAD54L, RAD51C, RAD54B, RAD52, RPA2, TOP3A, RAD51B, SEM1, POLD1, RAD51, RPA1, NBN, XRCC2",2.80134291304558,0.614393726401688,TRUE +"H1299","Input","KEGG_HUNTINGTONS_DISEASE",0.27481,0.94,0.512,3801,1,"COX7B2, DNAI1, TBP, POLR2D, COX8C, NDUFB9, UQCRFS1, IFT57, TBPL1, POLR2I, POLR2A, NDUFA9, CYC1, PLCB4, TGM2, SLC25A31, SDHB, DLG4, UQCRB, COX6B1, COX4I1, NDUFA7, ATP5MC1, HIP1, HDAC2, ATP5F1B, CLTA, RCOR1, TFAM, DNAL1, POLR2K, COX8A, NDUFS6, NDUFV2, SLC25A6, COX6C, HDAC1, HTT, POLR2J, TAF4B, NDUFB1, POLR2E, CLTC",0.290730039024169,0,FALSE +"H1299","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.30585,1.04,0.356,1574,1,"CACNG7, CACNB4, CACNG8, CACNG6, ITGA4, ITGA10, SLC8A1, TPM2, PRKAG2, ITGA6, CACNA2D1, TGFB1",0.448550002027125,0,FALSE +"H1299","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.26101,0.901,0.565,2189,1,"PIK3CG, ISYNA1, IMPA1, PLCD4, INPP5E, PIKFYVE, PLCB4, PIK3CB",0.247951552180562,0,FALSE +"H1299","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.1952,-0.716,0.876,16279,0.965,"SHC3, EIF4E2, PRKAB2, SOS2, GSK3B, PRKACB, PHKB, GYS1, MKNK1, PPP1R3B, PDPK1, PPP1R3D, CBLC, IKBKB, SOCS4, PHKG1, FLOT2, SORBS1, HK1, MAPK3, FOXO1, CBLB, PPP1CB, IRS2, ARAF",0.0574958938319193,0.0154726866562074,FALSE +"H1299","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.29015,0.974,0.467,1574,1,"MAP3K14, ITGA4, MADCAM1, CD40, TGFB1",0.330683119433888,0,FALSE +"H1299","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.19629,-0.724,0.897,14369,0.972,"CNTFR, IL20RA, IL12RB1, TSLP, IL5, SPRY3, IFNGR1, IL21R, IL3RA, IL2RG, IL24, SOCS1, IL7R, PIAS1, IL20RB, CREBBP, CSF2, CSF2RA, STAT6, STAM, SOS2, IL22RA1, IL11, SOCS5, CISH, IL15, CBLC, STAT4, IFNLR1, IL6, STAT2, STAT1, IL15RA, SOCS4, STAT3, EP300, IL6R, PTPN6, IRF9, CBLB, STAT5A, STAT5B",0.0472075569559079,0.0123337350737254,FALSE +"H1299","Input","KEGG_LEISHMANIA_INFECTION",-0.24432,-0.903,0.567,15945,0.761,"FCGR2A, IL1A, IL1B, TAB1, TLR2, TLR4, NCF2, PTGS2, MAPK13, STAT1, C3, MAPK3, PTPN6, TRAF6, MYD88",0.246416941107093,0.118615343229427,FALSE +"H1299","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.19773,0.675,0.908,4294,1,"PIK3CG, ITGAM, ITGA4, VASP, CLDN20, PXN, JAM3, BCAR1, MAPK11, MAPK12, PIK3CB, PTK2, CYBB, PRKCG, CLDN15, EZR, PTPN11, SIPA1, ICAM1, MYL9, PIK3CD, ACTG1, VCL, MYL12A, GNAI2, OCLN, MYL12B, MMP9, AFDN, CYBA",0.0419141514789149,0,FALSE +"H1299","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.47181,-1.71,0.0387,14291,0.377,"ECHS1, EHHADH, YOD1, ALDH2",1.41228903498109,0.423658649794207,FALSE +"H1299","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.49029,-1.79,0.0274,10518,0.35,"PLA2G12B, CYP1A2, PLA2G4B, PLA2G5, PLA2G2C, PLA2G2F, CYP2C19, CYP2C9, CYP2E1, PLA2G4E, CYP3A4, PLA2G2A, PLA2G3, CYP2C18, PLA2G6, ALOX15, CYP2J2, PLA2G10, CYP3A7, CYP3A5, AKR1B10, PLA2G4A, PLA2G12A",1.56224943717961,0.455931955649724,FALSE +"H1299","Input","KEGG_LONG_TERM_DEPRESSION",-0.17187,-0.623,0.961,11611,0.967,"PLA2G2F, GNA12, PPP2CB, GNAI3, PRKG2, GNA13, PRKCB, NOS1, PLA2G4E, GRID2, PLA2G2A, CRHR1, IGF1, PLA2G3, GRIA3, PLCB1, PLA2G6, PRKCA, GUCY1A1, PPP2R1A, ITPR3, PLA2G10, ITPR1, GNAO1, GNAQ, RYR1, IGF1R, PLCB2, PLA2G4A, MAPK3, PLA2G12A, ARAF",0.0172766123314547,0.0145735259169983,FALSE +"H1299","Input","KEGG_LONG_TERM_POTENTIATION",-0.29678,-1.09,0.308,14832,0.6,"ITPR3, ATF4, GRIN2C, CREBBP, CACNA1C, ITPR1, RPS6KA1, CAMK2B, GNAQ, PRKACB, ADCY1, PLCB2, EP300, RAP1A, MAPK3, RPS6KA2, PPP1CB, PPP3CB, ARAF",0.511449283499556,0.221848749616356,FALSE +"H1299","Input","KEGG_LYSINE_DEGRADATION",0.20615,0.714,0.874,3083,1,"EHMT2, NSD2, KMT5A, SETD1A, DLST, ACAT2, EHMT1, DOT1L",0.058488567365597,0,FALSE +"H1299","Input","KEGG_LYSOSOME",-0.35284,-1.29,0.127,14720,0.375,"AP3S2, SLC11A2, NPC2, GNS, TPP1, PPT1, HYAL1, ATP6V0A1, GM2A, CD63, SMPD1, ATP6V0A4, GBA, GGA2, ACP5, GNPTAB, HEXA, CTSO, CTSH, ACP2, CTSB, ABCA2, GLB1, AGA, IDUA, CLN5, ARSA, ATP6AP1, FUCA1, GNPTG, SCARB2, LIPA, CTSS, LAMP1, IDS, CTSD, ASAH1, LAPTM4A, LAMP2, PSAP, HGSNAT, NAGLU, SUMF1",0.896196279044043,0.425968732272281,FALSE +"H1299","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.20847,0.703,0.871,3714,1,"CACNA1A, CACNG7, CACNB4, MAP3K14, CACNG8, CACNG6, CACNA1B, RELB, FLNC, NFKB2, NR4A1, DAXX, FOS, MEF2C, HSPA1L, HSPA8, FGF5, MAP3K12, CACNA2D1, SRF, STK4, MAP2K3, MAPK8IP2, FGF12, PAK2, HSPA1A, MECOM, TGFB1, MAP3K7, HSPA1B, MAPK11, RASGRP2, AKT1, MAP3K5, MAP2K2, DUSP1, MAPK12, FGF11, CRK, MAPKAPK3, PRKCG, TNFRSF1A, AKT2, RAC3, TRAF2, ECSIT, RRAS, HSPB1, JUND, MAPK7, MAP3K3, FGF1, PPP3R2, NRAS, NFKB1, MAP4K4, RPS6KA4, MAPK8IP1, ARRB2",0.0599818449923368,0,FALSE +"H1299","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.22963,0.798,0.731,208,1,"GCK",0.13608262304214,0,FALSE +"H1299","Input","KEGG_MELANOGENESIS",-0.22376,-0.812,0.678,15411,0.883,"WNT4, WNT7A, ADCY4, CREBBP, ADCY9, GNAO1, CAMK2B, ADCY5, DVL3, GNAQ, GSK3B, PRKACB, WNT11, ADCY6, ADCY1, PLCB2, CREB3L2, MITF, ADCY7, WNT5A, EP300, EDN1, MAPK3, WNT7B, KITLG",0.168770306132937,0.0540392964224314,FALSE +"H1299","Input","KEGG_MELANOMA",0.19777,0.666,0.913,3514,1,"PIK3CG, FGF5, FGF12, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, FGF11, AKT2, PIK3CD, FGF1, NRAS",0.039529222465701,0,FALSE +"H1299","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.44672,-1.66,0.0193,11789,0.277,"AKR1C4, CYP2C19, UGT2B15, GSTP1, GSTA2, GSTM3, CYP2C9, CYP2E1, CYP1B1, CYP2B6, CYP2F1, CYP3A4, GSTA1, ADH1C, GSTM4, CYP2C18, GSTO1, AKR1C2, CYP3A7, UGT2B7, GSTM1, CYP1A1, ALDH3B2, MGST3, CYP3A5, MGST1, GSTZ1, ALDH1A3, ALDH3A1, AKR1C1, GSTO2, GSTT2, DHDH, EPHX1, CYP2S1, AKR1C3, MGST2",1.71444269099223,0.557520230935551,FALSE +"H1299","Input","KEGG_MISMATCH_REPAIR",0.51204,1.78,0.0193,4775,0.418,"RFC1, RPA2, POLD1, RFC2, RPA1, RFC5, MSH3, MSH6, MLH1, POLD2, RFC4, MSH2",1.71444269099223,0.378823718224965,FALSE +"H1299","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.24636,-0.916,0.532,17065,0.752,"PDPK1, MLST8, HIF1A, MAPK3, VEGFA, DDIT4, VEGFB, RPS6KA2",0.274088367704952,0.123782159408358,FALSE +"H1299","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.17933,-0.648,0.96,14477,0.967,"KLRK1, SHC2, LCK, IFNGR1, ITGB2, TNF, KLRC2, RAET1G, BID, CSF2, VAV1, RAC1, SHC3, RAET1L, ULBP2, SOS2, SH3BP2, PLCG2, NFATC2, TNFRSF10B, ICAM2, SYK, VAV3, TNFSF10, MAPK3, PTPN6, RAC2, PTK2B, PPP3CB, ARAF",0.0177287669604316,0.0145735259169983,FALSE +"H1299","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.27024,0.922,0.512,949,1,"PTGER1, GABRA4, NTSR1, MC5R, S1PR1, NPFFR2, P2RX5, NMUR1, CHRNB1, GABRD, F2RL1, GRIN2D, ADORA2A, GABRB3, ADRA1B, TBXA2R, P2RY1, ADRA2C, MC1R",0.290730039024169,0,FALSE +"H1299","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.2068,0.704,0.877,3664,1,"PIK3CG, NFKBIB, CALM1, YWHAQ, ZNF274, SH2B3, IRAK2, MAPK11, AKT1, MAP3K5, MAP2K2, YWHAZ, PRDM4, MAPK12, NFKBIE, PSEN1, PIK3CB, CRK, RAPGEF1, PTPN11, AKT2, IRAK1, PIK3CD, TP73, MAPK7, MAP3K3, NRAS, NFKB1, SHC1, RPS6KA4",0.0570004066339595,0,FALSE +"H1299","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.48124,-1.72,0.0304,16535,0.404,"NT5C1B, NMNAT2, NAMPT, NT5C3A, NNMT, NMRK1, NADSYN1, QPRT, NUDT12, NNT",1.51712641639125,0.393618634889395,FALSE +"H1299","Input","KEGG_NITROGEN_METABOLISM",-0.44836,-1.69,0.0289,14401,0.336,"GLS2, HAL, GLUD2, CA14, GLS, CA8, CTH, GLUL, CA9, AMT, CPS1, CA12",1.53910215724345,0.473660722610156,FALSE +"H1299","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.27656,0.957,0.481,809,1,"HSP90AA1, CXCL2, CARD18, CARD8, NFKBIB, NLRP1, HSP90AB1, BIRC3",0.317854923626168,0,FALSE +"H1299","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.2977,1,0.409,3035,1,"PRKDC, XRCC4, XRCC5",0.388276691992658,0,FALSE +"H1299","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.23522,0.788,0.74,3514,1,"PIK3CG, STK4, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, PRKCG, AKT2, PIK3CD, NRAS",0.130768280269024,0,FALSE +"H1299","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.26416,-0.966,0.452,16297,0.706,"CTBP2, DVL3, DTX1, MFNG, NOTCH1, MAML2, PSEN2, LFNG, DTX4, EP300, APH1A, CIR1, DTX3L",0.344861565188618,0.151195298948196,FALSE +"H1299","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.40729,1.4,0.0978,3479,0.611,"ERCC1, RFC1, GTF2H4, CDK7, GTF2H5, RPA2, POLE3, ERCC3, POLE2, RAD23A, ERCC2, POLD1, POLE, RFC2, RPA1, RFC5",1.0096611452124,0.213958789757446,FALSE +"H1299","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.2575,-0.948,0.484,14460,0.727,"ST6GAL1, MGAT3, MOGS, MAN2A1, MGAT5, MGAT1, ALG9, ALG5, STT3A, ALG2, MGAT4A, MAN1C1, ALG11, MAN1A2, B4GALT1",0.315154638355588,0.138465589140962,FALSE +"H1299","Input","KEGG_OLFACTORY_TRANSDUCTION",0.20492,0.701,0.873,1072,1,"OR3A2, OR8G1, OR3A1, OR8D2, OR52H1, OR2J2, OR8G5, OR8A1, OR1F1, OR2W3, CALM1",0.0589857562944303,0,FALSE +"H1299","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.50595,1.71,0.0295,4076,0.445,"FTCD, MTHFD1L, TYMS, MTHFD2L, MTHFD1, GART, DHFR, ATIC",1.53017798402184,0.351639989019068,FALSE +"H1299","Input","KEGG_OOCYTE_MEIOSIS",0.33974,1.17,0.224,4362,0.861,"STAG3, FBXO43, BUB1, ANAPC4, ESPL1, CDC20, CCNB1, AURKA, CPEB1, ANAPC13, CALM1, PLK1, YWHAQ, MAD2L2, PTTG1, CCNB2, PPP2R5D, PPP2R5C, YWHAZ, MAPK12, CDC25C, ANAPC1, FBXO5, PPP1CC, SMC1A, SMC1B, SGO1, ITPR2, ANAPC7, PPP3R2, ANAPC5, CALM3, CCNE2, PRKX, PPP2R5E, YWHAB, CUL1, PTTG2",0.649751981665837,0.0649968485463452,FALSE +"H1299","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.46715,-1.69,0.0385,15905,0.336,"MAN2C1, GBA, HEXA, ENGASE, GLB1, AGA, FUCA1",1.4145392704915,0.473660722610156,FALSE +"H1299","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.22936,0.786,0.74,3724,1,"COX7B2, COX8C, NDUFB9, UQCRFS1, ATP5ME, ATP6V1C1, NDUFA9, CYC1, SDHB, UQCRB, COX6B1, COX4I1, NDUFA7, ATP5MC1, ATP6V1D, ATP5F1B, ATP6V0E2, NDUFA11, ATP6V1H, COX8A, NDUFS6, NDUFV2, COX6C, NDUFB1, COX10",0.130768280269024,0,FALSE +"H1299","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.4609,-1.67,0.0345,15740,0.304,"ST6GALNAC1, GCNT4, GALNT6, GALNT9, GALNT2, GCNT3, GALNT5, GCNT1, GALNT1, ST3GAL1, GALNT7, GALNT3, GALNT12, B4GALT5",1.46218090492673,0.517126416391246,FALSE +"H1299","Input","KEGG_P53_SIGNALING_PATHWAY",-0.20368,-0.751,0.842,14685,0.952,"PTEN, SESN3, BAX, TSC2, CYCS, MDM2, BID, CCNE1, DDB2, THBS1, TNFRSF10B, SERPINB5, GADD45G, ZMAT3, CASP8, MDM4, SIAH1, CCNG2, SFN, IGFBP3, COP1",0.0746879085003505,0.0213630516155257,FALSE +"H1299","Input","KEGG_PANCREATIC_CANCER",-0.25745,-0.928,0.482,15724,0.763,"IKBKG, RAC1, ARHGEF6, TGFBR1, CHUK, ERBB2, EGF, STAT1, IKBKB, STAT3, MAPK3, VEGFA, RAC2, VEGFB, RALA, ARAF",0.31695296176115,0.11747546204512,FALSE +"H1299","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.41051,-1.5,0.0674,17871,0.281,"PANK2, PANK1, PPCS",1.17134010346468,0.55129368009492,FALSE +"H1299","Input","KEGG_PARKINSONS_DISEASE",0.29047,0.991,0.429,3628,1,"COX7B2, COX8C, LRRK2, NDUFB9, UQCRFS1, NDUFA9, CYC1, UCHL1, SLC25A31, SDHB, HTRA2, UQCRB, COX6B1, COX4I1, NDUFA7, ATP5MC1, ATP5F1B, UBE2G1, GPR37, COX8A, UBE2J2, NDUFS6, NDUFV2, SLC25A6, COX6C, PARK7, NDUFB1, UBB",0.367542707815276,0,FALSE +"H1299","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.20995,0.716,0.842,4841,1,"ARPC1A, TUBB3, YWHAQ, NCL, YWHAZ, ARPC1B, TUBB6, EZR, TUBB4B, TUBA1C, ACTG1, TUBB, OCLN, TUBB4A, TUBA1A, TUBB2B, ARPC5L, ARHGEF2, RHOA, TUBA1B, TUBB2A",0.0746879085003505,0,FALSE +"H1299","Input","KEGG_PATHWAYS_IN_CANCER",-0.27059,-0.993,0.405,16579,0.684,"TGFBR1, PLCG2, CHUK, GSK3B, PDGFRB, LAMA4, BCR, FN1, WNT11, ERBB2, RASSF5, COL4A6, LAMA1, LAMC1, BMP2, PPARG, ELOB, CBLC, PTGS2, IGF1R, CUL2, CTNNA1, DAPK2, SUFU, SLC2A1, PPARD, FGFR3, IL6, FGF13, EGF, STAT1, CASP8, FH, IKBKB, CDH1, LAMB1, MITF, MMP2, FGFR2, HIF1A, GLI2, BMP4, ARNT2, WNT5A, LAMA3, STAT3, XIAP, RXRA, EP300, CXCL8, MAPK3, WNT7B, EGLN3, FADD, VEGFA, FOXO1, RAC2, CBLB, KITLG, TRAF4, FLT3LG, VEGFB, COL4A1, NCOA4, EPAS1, STAT5A, DAPK1, RARA, COL4A2, PDGFA, TRAF6, RALA, JUP, STAT5B, ARAF",0.392544976785331,0.164943898279884,FALSE +"H1299","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.32055,-1.15,0.218,9885,0.557,"UGT2B11, UGT2B17, UGT2B4, UGDH, AKR1B1, UGP2, UGT2A1, UGT2A3, UGT2B15, CRYL1, UGT2B7, DCXR, DHDH",0.661543506395395,0.254144804826271,FALSE +"H1299","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.32056,-1.16,0.216,16980,0.56,"PGM1, H6PD, RBKS, TKT, G6PD, TALDO1, ALDOC",0.665546248849069,0.2518119729938,FALSE +"H1299","Input","KEGG_PEROXISOME",-0.24,-0.877,0.592,14162,0.774,"PEX11B, SLC25A17, PXMP2, SLC27A2, EHHADH, ACSL1, PHYH, ACOX1, ACAA1, PEX11A, FAR1, PEX6, HMGCL, PIPOX, DDO, MVK, MPV17L, PRDX5, ABCD3, ACSL5, SCP2, IDH1, CAT, PEX12, NUDT12, DHRS4, IDH2",0.22767829327708,0.111259039317107,FALSE +"H1299","Input","KEGG_PHENYLALANINE_METABOLISM",-0.4242,-1.53,0.0597,11410,0.297,"TAT, AOC3, PAH, AOC2, DDC, MAOA, IL4I1, PRDX6, MAOB, ALDH3B2, ALDH1A3, ALDH3A1",1.22402566887063,0.527243550682788,FALSE +"H1299","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.1855,0.629,0.96,4331,1,"PIK3CG, IMPA1, PLCD4, INPP5E, CALM1, PIKFYVE, PLCB4, PIK3CB, DGKE, PRKCG, ITPR2, ITPKA, PIK3CD, DGKD, CALM3, INPP5K, SYNJ2, SYNJ1",0.0177287669604316,0,FALSE +"H1299","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.40441,-1.49,0.0501,14919,0.27,"BLVRA, UGT2B7, HMBS, EARS2, HMOX2, COX15, CP, MMAB, UROS, FTH1",1.30016227413275,0.568636235841013,FALSE +"H1299","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.2951,-1.09,0.291,14313,0.6,"CPT2, CPT1B, SLC27A2, EHHADH, FABP3, AQP7, ACSL1, NR1H3, ACOX1, ACAA1, LPL, CD36, PCK2, OLR1, UBC, PLIN1, PDPK1, PPARG, FADS2, CYP27A1, PPARD, CPT1C, FABP6, ACSL5, SCP2, ME1, PPARA, SORBS1, RXRA",0.536107011014093,0.221848749616356,FALSE +"H1299","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.27212,-0.994,0.398,13901,0.691,"CH25H, HSD17B4, CYP7B1, CYP27A1, HSD3B7, SCP2",0.400116927926312,0.160521952625802,FALSE +"H1299","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.16392,0.56,0.981,15984,1,"CD40, TAP2, CD19, UNG, TAP1, RFX5, RFXANK, TNFRSF13C, BTK, JAK3, ADA, ZAP70, RAG2, TNFRSF13B, CD40LG, CD8B, ICOS, CD3E, CD4, AICDA, AIRE, RFXAP, RAG1, DCLRE1C, PTPRC, CD3D, CD79A, CIITA, IGLL1, LCK, IL2RG, IL7R, IKBKG, BLNK, CD8A",0.0083309926200515,0,FALSE +"H1299","Input","KEGG_PRION_DISEASES",-0.31305,-1.15,0.255,16130,0.557,"IL1A, CCL5, IL1B, PRKACB, NOTCH1, NCAM1, LAMC1, IL6, MAPK3",0.593459819566045,0.254144804826271,FALSE +"H1299","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.3711,1.26,0.178,3712,0.691,"PIK3CG, HSP90AA1, CCNA1, BUB1, ANAPC4, CCNB1, CPEB1, HSP90AB1, ANAPC13, PLK1, MAD2L2, CCNB2, MAPK11, AKT1, MAPK12, PIK3CB, CDC25C, CDC25A, ANAPC1, CCNA2, PDE3B, AKT2, FZR1, PIK3CD, ANAPC7, ANAPC5, GNAI2",0.749579997691106,0.160521952625802,FALSE +"H1299","Input","KEGG_PROPANOATE_METABOLISM",-0.46552,-1.64,0.0543,14291,0.281,"ECHS1, EHHADH, ACACA, HIBCH, ACSS3, LDHA, SUCLA2, ABAT, ALDH6A1, ALDH2, PCCA, ACSS1, MCEE",1.26520017041115,0.55129368009492,FALSE +"H1299","Input","KEGG_PROSTATE_CANCER",-0.23597,-0.864,0.622,15482,0.786,"PDGFRA, MDM2, CCNE1, CREBBP, IKBKG, AR, SOS2, CHUK, GSK3B, PDGFRB, ERBB2, PDPK1, IGF1R, EGF, CREB3L2, IKBKB, FGFR2, EP300, MAPK3, FOXO1, PDGFA, ARAF",0.206209615309181,0.104577453960592,FALSE +"H1299","Input","KEGG_PROTEASOME",0.39336,1.35,0.14,2638,0.589,"PSMB1, PSMC4, PSMB7, PSMD8, PSMC1, PSMB6, PSMC5, PSMD7, PSMD4, PSMD14, PSMD1, SEM1",0.853871964321762,0.229884705212898,FALSE +"H1299","Input","KEGG_PROTEIN_EXPORT",-0.55924,-2.01,0.0165,15585,0.31,"SEC61B, SEC62, IMMP1L, SRP9, SRP54, SEC61G, OXA1L, SRP72, SPCS2",1.78251605578609,0.508638306165727,FALSE +"H1299","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.43501,-1.59,0.0497,13639,0.286,"ATP1B2, ATP1A2, FXYD2, GLS2, GLUD2, PCK2, AQP1, GLS, SLC38A3, ATP1A1, SLC4A4, MDH1",1.30364361126667,0.543633966870957,FALSE +"H1299","Input","KEGG_PURINE_METABOLISM",0.28487,0.96,0.442,3713,1,"AK5, POLR2D, NPR2, NME2, APRT, NT5E, AK4, POLR1E, POLA1, PRIM1, POLR3G, NME6, PFAS, PDE6D, PDE4A, PDE4C, POLR2I, POLR2A, POLE3, ENTPD5, AMPD2, POLE2, GMPS, NT5M, IMPDH2, NME1, POLR2K, POLD1, PDE3B, POLE, RRM2, PDE6B, RRM2B, GART, PRIM2, NUDT2, NME4, PNPT1, POLR2J, POLR2E",0.354577730650908,0,FALSE +"H1299","Input","KEGG_PYRIMIDINE_METABOLISM",0.37526,1.29,0.151,4271,0.653,"POLR2D, DHODH, NME2, DTYMK, NT5E, POLR1E, POLA1, PRIM1, POLR3G, TYMS, NME6, POLR2I, POLR2A, DUT, POLE3, ENTPD5, POLE2, CAD, NT5M, NME1, POLR2K, POLD1, POLE, UMPS, RRM2, RRM2B, PRIM2, NUDT2, NME4, PNPT1, POLR2J, POLR2E, TXNRD2, UCK2, POLR3H, POLR1C, CTPS1",0.821023052706831,0.185086818724926,FALSE +"H1299","Input","KEGG_PYRUVATE_METABOLISM",-0.27126,-0.985,0.44,17768,0.691,"HAGH, MDH1, ME1, PC, ALDH2, ACSS1",0.356547323513813,0.160521952625802,FALSE +"H1299","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.16551,0.564,0.988,4043,1,"PIK3CG, ITGAM, PAK4, ITGA4, ITGA10, PXN, PFN1, ARPC1A, FGF5, MYLK2, ITGA6, FGF12, PIKFYVE, PAK2, F2R, BCAR1, APC2, MAP2K2, ARPC1B, PIK3CB, PTK2, TIAM1, FGF11, CRK, EZR, PPP1CC, WASF1, RAC3, RRAS, PPP1R12A, MYH10, MYL9, PIK3CD, FGF1, NRAS, ACTG1, VCL, MYL12A, CFL2, FGD1, FGFR1, ITGA2, MYL12B, WASF2",0.00524305541237188,0,FALSE +"H1299","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.26931,0.923,0.523,4083,1,"IFNA13, PIK3R4, ATG7, ATG12, GABARAPL2, ATG5, ATG4B, ULK3",0.281498311132726,0,FALSE +"H1299","Input","KEGG_RENAL_CELL_CARCINOMA",-0.31509,-1.13,0.278,17178,0.562,"ELOB, CUL2, SLC2A1, PAK6, FH, HIF1A, ARNT2, EP300, RAP1A, GAB1, MAPK3, EGLN3, VEGFA, VEGFB, EPAS1, ARAF",0.555955204081924,0.250263684430939,FALSE +"H1299","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.31974,1.09,0.299,4412,0.989,"THOP1, MME, ANPEP, ENPEP, NLN",0.52432881167557,0.0048037084028206,FALSE +"H1299","Input","KEGG_RETINOL_METABOLISM",-0.28171,-1.03,0.364,11816,0.664,"CYP2C19, UGT2B15, CYP2A7, CYP2C9, RPE65, CYP26C1, CYP2B6, CYP26A1, CYP3A4, CYP4A22, ADH1C, CYP2C18, DHRS3, CYP2A6, PNPLA4, CYP3A7, UGT2B7, CYP1A1, DHRS9, BCO1, RETSAT, RDH12, RDH16, CYP3A5, ALDH1A1, CYP26B1, DHRS4, DHRS4L2",0.438898616350944,0.177831920631982,FALSE +"H1299","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.51304,-1.92,0.0113,13276,0.282,"ENPP3, ACP4, MTMR7, FLAD1, ACP1, ACP5, ACP2, ACP6, MTMR6",1.94692155651658,0.549750891680639,FALSE +"H1299","Input","KEGG_RIBOSOME",0.33746,1.14,0.25,5670,0.871,"RPS20, RPL7, RPL13, RPS12, RPS16, RPL26L1, RPL8, RPL35A, RPL30, RPS4X, RPS10, RPSA, RPS19, RPS28, RPL18A, RPS15, UBA52, RPL9, RPL22, RPL29, RPL17, RPL11, MRPL13, RPL35, RPL14, RPS26, RPL41, RPL6, RPL31, RPL5, RPS21, RPS6, RPL3, RPS23, RPS7, RPLP0, RPS27A, RPL4, RPL38, RPL32, RPL37A, RPS9, RPL34, RPL26, RPS25",0.602059991327962,0.0599818449923368,FALSE +"H1299","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.2561,-0.921,0.546,16349,0.75,"DDX3Y, CYLD, OTUD5, CHUK, MAPK13, CASP8, IKBKB, MAVS, CXCL8, IKBKE, FADD, DHX58, CASP10, MAP3K1, TRAF6",0.262807357295263,0.1249387366083,FALSE +"H1299","Input","KEGG_RNA_DEGRADATION",0.38539,1.31,0.164,5451,0.645,"HSPD1, PAPOLA, SKIV2L, LSM7, EDC4, LSM2, DCP2, EXOSC10, EXOSC3, EXOSC5, EXOSC2, ENO1, CNOT9, CNOT7, PNPT1, EXOSC4, HSPA9, LSM3, CNOT3, LSM6, MTREX, ZCCHC7, MPHOSPH6, DCP1B, LSM4, LSM1, EXOSC7, EXOSC6",0.785156151952302,0.190440285364732,FALSE +"H1299","Input","KEGG_RNA_POLYMERASE",0.40475,1.37,0.114,4238,0.585,"POLR2D, POLR1E, POLR3G, POLR2I, POLR2A, POLR2K, POLR2J, POLR2E, POLR3H, POLR1C",0.943095148663527,0.23284413391782,FALSE +"H1299","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.31319,-1.13,0.237,14276,0.562,"GGT6, GGT5, MAT1A, HEMK1, CTH, LCMT1, GGT1, LCMT2, AHCYL1",0.625251653989896,0.250263684430939,FALSE +"H1299","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.21331,0.718,0.845,3546,1,"PIK3CG, LAMC3, TRAF3, BIRC3, PIAS3, ITGA6, TRAF1, E2F2, AKT1, CDKN2B, PIK3CB, E2F3, PTK2, CDK6, CKS1B, AKT2, TRAF2, PIAS4, PIK3CD, NFKB1",0.0731432910503077,0,FALSE +"H1299","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.35173,-1.3,0.145,15917,0.37,"STX3, STX19, SNAP23, BNIP1, STX17, SEC22B, SNAP47, GOSR2, STX12, GOSR1, VAMP8, VAMP5, BET1L, STX6",0.838631997765025,0.431798275933005,FALSE +"H1299","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.2691,-0.999,0.413,14043,0.701,"NEU4, GLA, KDSR, DEGS2, GAL3ST1, SGPP2, SMPD1, DEGS1, GBA, ACER3, PLPP3, GLB1, SGPL1, ARSA, ASAH1",0.384049948343599,0.154281982033341,FALSE +"H1299","Input","KEGG_SPLICEOSOME",0.49538,1.68,0.0364,4233,0.415,"SNRPD2, SF3B5, SNRPC, BUD31, DHX16, DHX38, MAGOHB, HSPA1L, HSPA8, PUF60, WBP11, SNW1, RBM8A, HNRNPA1, SART1, HSPA1A, LSM7, ALYREF, HSPA1B, CTNNBL1, U2SURP, PRPF8, PRPF6, DDX39B, LSM2, XAB2, HNRNPM, RBM22, SNRPF, CDC40, PRPF31, TRA2B, HNRNPU, RBM25, SNRNP200, TCERG1, SF3B4, SRSF9, DHX15, SNRNP40, SYF2, ISY1, SNRPA, SNRPG, SNRPB, PPIL1, HNRNPK, DDX23, SF3A1, SF3A3, SF3A2, PRPF4, TXNL4A, SRSF1, HNRNPA3, CDC5L, LSM3, HSPA2, SNRPA1, U2AF1",1.43889861635094,0.381951903287907,FALSE +"H1299","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.17176,-0.633,0.965,9337,0.969,"UGT2B10, SI, AMY2B, UGT2B11, GBA3, UGT2B17, AMY1C, AMY1A, UGT2B4, UGDH, HK3, GAA, GBE1, UGP2, G6PC2, UGT2A1, UGT2A3, UGT2B15, MGAM, ENPP3, PYGM, TREH, HK2, UXS1, PGM2L1, UGT2B7, AGL, PGM1, GYS1, HK1",0.0154726866562074,0.0136762229492347,FALSE +"H1299","Input","KEGG_STEROID_BIOSYNTHESIS",-0.58004,-2.11,0.0028,15796,0.565,"DHCR7, NSDHL, DHCR24, LIPA, SC5D, MSMO1",2.55284196865778,0.247951552180562,FALSE +"H1299","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.30917,-1.14,0.241,14742,0.566,"AKR1C2, CYP3A7, CYP19A1, SRD5A1, UGT2B7, CYP1A1, CYP7B1, HSD17B2, CYP3A5, HSD11B2, SRD5A3, STS, AKR1C1, HSD17B12, AKR1C3",0.617982957425132,0.247183568811729,FALSE +"H1299","Input","KEGG_SULFUR_METABOLISM",-0.35104,-1.31,0.131,16556,0.375,"SULT1A2, BPNT1, SULT1A1",0.882728704344236,0.425968732272281,FALSE +"H1299","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.26652,-0.967,0.441,11568,0.713,"IL10, C5, FCGR2B, FCGR2C, ACTN2, C6, CD86, CTSG, GRIN2A, SNRPD3, TNF, FCGR1A, ELANE, FCGR2A, C2, SNRPD1, C3, TRIM21, C1S, C1R",0.355561410532161,0.146910470148134,FALSE +"H1299","Input","KEGG_TASTE_TRANSDUCTION",0.46914,1.62,0.0578,2683,0.395,"CACNA1A, SCNN1G, CACNA1B, TAS2R43, TAS2R8, SCNN1B, TAS2R14, TAS2R40, TAS2R46, TAS2R50, TAS2R19, GNB3, TAS2R20, TAS2R10",1.23807216157947,0.40340290437354,FALSE +"H1299","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.40719,1.41,0.0863,1279,0.64,"CDO1, GAD1",1.06398920428479,0.193820026016113,FALSE +"H1299","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.34964,-1.28,0.156,16796,0.381,"MVK, HMGCS1, GGPS1",0.806875401645538,0.419075024324381,FALSE +"H1299","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.19662,-0.737,0.884,14662,0.969,"THBS2, CHRD, PPP2R1A, TNF, BMPR1A, RBL2, ACVRL1, CREBBP, RPS6KB2, THBS1, TGFBR1, INHBE, INHBB, BMP2, SMAD7, TFDP1, SKP1, INHBA, SMAD6, LTBP1, FST, BMP4, EP300, MAPK3, SMAD5",0.0535477349869269,0.0136762229492347,FALSE +"H1299","Input","KEGG_THYROID_CANCER",-0.35324,-1.32,0.114,17134,0.379,"PPARG, CDH1, RXRA, MAPK3, NCOA4",0.943095148663527,0.421360790031928,FALSE +"H1299","Input","KEGG_TIGHT_JUNCTION",0.18362,0.634,0.952,4356,1,"MYH15, PARD6A, CSNK2B, CLDN20, PPP2R2C, JAM3, AKT1, YBX3, RAB3B, PRKCG, CLDN15, EPB41L2, MPDZ, SYMPK, AKT2, RRAS, LLGL1, MYH10, MYL9, TJAP1, SPTAN1, MYH3, NRAS, ACTG1, CGN, MYL12A, GNAI2, PRKCZ, OCLN, MYL12B, PRKCE, AFDN, MAGI1",0.0213630516155257,0,FALSE +"H1299","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.29954,-1.1,0.293,16314,0.602,"CCL5, IL1B, TAB1, CHUK, TLR2, LY96, TLR4, TLR1, IRF5, MAPK13, IL6, TLR5, TIRAP, STAT1, CASP8, IKBKB, TOLLIP, TICAM2, MAP2K6, TLR3, CXCL8, MAPK3, IKBKE, FADD, MAP3K8, TRAF6, MYD88",0.533132379645891,0.220403508742175,FALSE +"H1299","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.43404,-1.62,0.0245,12346,0.269,"INMT, GCDH, CYP1B1, WARS2, ACMSD, DDC, MAOA, AANAT, ECHS1, AOC1, AADAT, EHHADH, IL4I1, IDO1, HAAO, KMO, MAOB, CYP1A1, HADH, TDO2, KYNU, CAT, ALDH2",1.61083391563547,0.570247719997592,FALSE +"H1299","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29037,1.01,0.391,403,1,"PIK3CG, CACNA1A, GCK, CACNA1B",0.407823242604133,0,FALSE +"H1299","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.25106,0.838,0.654,1279,1,"HSPD1, GAD1",0.184422251675733,0,FALSE +"H1299","Input","KEGG_TYROSINE_METABOLISM",-0.2501,-0.906,0.55,11110,0.764,"DBH, DCT, TAT, AOC3, COMT, TYR, AOC2, TPO, DDC, MAOA, ADH1C, TH, IL4I1, TYRP1, HEMK1, MAOB, ALDH3B2, HGD, GSTZ1, LCMT1, ALDH1A3, ALDH3A1, LCMT2",0.259637310505756,0.11690664142431,FALSE +"H1299","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.19907,0.697,0.897,2189,1,"PIK3CG, MAP3K14, PAK4, NFKBIB, FOS, PAK2, MAP3K7, MAPK11, AKT1, MAP2K2, MAPK12, NFKBIE, PIK3CB",0.0472075569559079,0,FALSE +"H1299","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.28473,-1.06,0.363,16976,0.632,"CDC16, TRIM32, KLHL9, FBXW8, UBOX5, ELOB, CBLC, CUL2, SKP1, ANAPC10, MGRN1, SIAH1, BTRC, UBE2I, XIAP, UBE2F, UBE2H, MID1, SYVN1, DET1, UBE2A, UBE2L6, CBLB, MAP3K1, UBA7, FBXW7, TRAF6, COP1, UBE2E1",0.440093374963888,0.199282921717615,FALSE +"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.62788,2.18,0,4488,0.248,"VARS2, PDHB, BCAT1, PDHA1",Inf,0.605548319173784,TRUE +"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.43423,-1.57,0.0503,14291,0.293,"ECHS1, EHHADH, IL4I1, DBT, HIBCH, ACAA1, HADHB, HMGCL, OXCT1, MCCC1, HADH, HMGCS1, ABAT, ALDH6A1, ALDH2, PCCA, MCEE, HIBADH",1.29843201494407,0.533132379645891,FALSE +"H1299","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.19437,-0.719,0.871,14244,0.97,"ADRA1D, EDNRA, PRKCA, MYLK3, GUCY1A1, ITPR3, CALCRL, PLA2G10, MYL6, CACNA1D, PRKCH, ADCY4, ACTG2, CACNA1C, ADCY9, ITPR1, PRKCD, ADCY5, GNAQ, PRKACB, PPP1R12B, ADCY6, ADCY1, RAMP2, PLCB2, RAMP1, ADCY7, PLA2G4A, MAPK3, PLA2G12A, PPP1CB, ARAF",0.0599818449923368,0.0132282657337552,FALSE +"H1299","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.32427,-1.2,0.215,16749,0.498,"PRKACB, ADCY6, ARHGDIB, RAB5A, AQP3, CREB3L2, RAB5B, DYNLL2, DCTN5, DCTN6, RAB5C",0.667561540084395,0.302770657240282,FALSE +"H1299","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.20612,-0.754,0.814,16606,0.956,"PLCG2, SRC, NFATC2, PTGS2, MAPK13, PLA2G4A, MAPK3, VEGFA, RAC2, PLA2G12A, MAPKAPK2, PPP3CB",0.0893755951107988,0.0195421077238999,FALSE +"H1299","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.35939,-1.34,0.108,12681,0.362,"MUC2, CFTR, ATP6V0D1, ATP6V1G3, KCNQ1, PDIA4, ATP6V0D2, PRKCA, ATP6V1C2, ACTB, SLC12A2, ATP6V0A1, SEC61B, ADCY9, ATP6V1E1, ERO1A, ATP6V1A, ATP6V0A4, ATP6V1B2, ATP6V1G2, PLCG2, PRKACB, TJP2, ATP6V1B1, ATP6AP1, SEC61G, ATP6V0E1, KDELR2, ARF1",0.96657624451305,0.441291429466834,FALSE +"H1299","Input","KEGG_VIRAL_MYOCARDITIS",0.14034,0.486,0.994,3926,0.998,"MYH15, CD40, ICAM1, RAC3, MYH10, MYH3, ACTG1, EIF4G3, EIF4G1",0.00261361560268669,0.000869458712628891,FALSE +"H1299","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.19241,-0.697,0.902,14778,0.957,"PPP2R1A, NKD1, FZD4, APC, WNT10A, WNT4, WNT7A, CREBBP, RAC1, CAMK2B, DAAM2, CTBP2, DVL3, MMP7, GSK3B, PRKACB, NFATC2, WNT11, LRP5, FRAT1, PORCN, PPARD, PLCB2, SKP1, NLK, PRICKLE2, WNT5A, VANGL2, SIAH1, BTRC, EP300, WNT7B, FRAT2, TBL1XR1, RAC2, DAAM1, PPP3CB",0.0447934624580583,0.0190880622231565,FALSE +"HCC44","Input","KEGG_ABC_TRANSPORTERS",-0.14437,-0.417,1,10995,0.999,"ABCC6, ABCB4, ABCA13, ABCB1, ABCG4, ABCA12, ABCD3, ABCA2, ABCB8, ABCC10, ABCB6, ABCB10, ABCD4, ABCB9",0,0.000434511774017692,FALSE +"HCC44","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.39866,-1.16,0.222,14933,0.504,"MAPK1, LEF1, EIF4EBP1, PIK3CA, RPS6KB1, PIM1, TCF7L1, GRB2, KRAS, RELA, IKBKB, PML, SOS1, RPS6KB2, HRAS, MAPK3, PIK3R2, BAD",0.653647025549361,0.297569463554475,FALSE +"HCC44","Input","KEGG_ADHERENS_JUNCTION",-0.26087,-0.761,0.867,12186,1,"WASL, TCF7L2, NECTIN1, CSNK2A1, SSX2IP, PARD3, RAC3, CREBBP, RHOA, INSR, IQGAP1, LMO7, ACP1, SORBS1, CDC42, MAPK1, LEF1, WASF2, CTNND1, TCF7L1, WASF3, FARP2, PTPN1, ERBB2, SRC, MAPK3",0.0619809025237897,0,FALSE +"HCC44","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.26187,-0.77,0.838,11172,1,"PRKAB2, PRKAB1, TNFRSF1B, SLC2A4, MTOR, AKT2, PTPN11, PPARA, STK11, PRKCQ, AKT1, ACACB, RXRA, PPARGC1A, MAPK10, CPT1C, NFKBIE, ACSL3, MAPK9, CAMKK1, TRADD, CAMKK2, ADIPOR1, RXRB, RELA, IKBKB, CPT1B, ACSL1, PRKAG1",0.0767559813697235,0,FALSE +"HCC44","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.23418,-0.679,0.934,14681,1,"GPT, GFPT1, CPS1, ABAT, ALDH5A1, GLUL, NIT2, GOT1",0.0296531237699066,0,FALSE +"HCC44","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.27633,-0.801,0.808,8977,1,"PIK3CG, FXYD2, NEDD4L, PIK3R5, IGF1, HSD11B1, SCNN1G, ATP1B2, PIK3CD, KCNJ1, SCNN1A, PRKCA, SCNN1B, PIK3CB, PRKCG, PIK3R3, INSR, NR3C2, PIK3R1, MAPK1, PDPK1, PIK3CA, KRAS, MAPK3, PIK3R2",0.0925886392254138,0,FALSE +"HCC44","Input","KEGG_ALLOGRAFT_REJECTION",0.53632,2.07,0,362,0.0756,"TNF, IL2, IL12B",Inf,1.12147820449879,TRUE +"HCC44","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.56047,-1.64,0.0137,17652,0.11,"PLA2G4B, PLA2G6, ACOX1, PLA2G12A",1.86327943284359,0.958607314841775,TRUE +"HCC44","Input","KEGG_ALZHEIMERS_DISEASE",-0.57556,-1.68,0.00636,15313,0.106,"GAPDH, LRP1, NDUFB2, PPP3CB, PPP3CC, PSEN2, UQCRC1, SDHB, APBB1, IDE, NDUFA9, ADAM10, NDUFS4, COX7B, NDUFV2, ATP5PF, GSK3B, NDUFS5, CASP3, NDUFA3, ATP5PB, NDUFB9, SDHD, SDHC, FADD, COX6B1, COX7A2L, UQCRQ, CALM2, UQCRFS1, APH1A, UQCRC2, CYC1, NDUFB7, CHP1, NDUFB1, UQCR11, ATP5PD, UQCRHL, ATP5F1E, NDUFA8, GNAQ, COX5A, NDUFA4, NDUFA10, NDUFS8, NDUFS2, COX7C, HSD17B10, NDUFV1, CDK5, NDUFB8, NDUFB4, NDUFC2, ATP5F1C, MAPK3, CALM3, CAPN1, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, COX6A1, PLCB3, NDUFA2, NDUFS3, APAF1, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, UQCRB, BAD, COX8A, NDUFB3",2.19654288435159,0.97469413473523,TRUE +"HCC44","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.50591,-1.47,0.0467,13716,0.196,"VARS2, EARS2, CARS2, TARS2, DARS2, FARS2, PARS2, IARS2, AARS2, SEPSECS, HARS2, MTFMT, NARS2",1.33068311943389,0.707743928643524,TRUE +"HCC44","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.47665,-1.41,0.0612,14409,0.249,"NPL, CMAS, GNE, GALK1, GPI, GFPT1, UXS1, CYB5R3, GMPPB, CYB5R1, GNPDA1, GALK2, AMDHD2, NAGK, PMM1, UGP2, GMPPA, MPI, GALT, FPGT",1.21324857785444,0.603800652904264,FALSE +"HCC44","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.40414,-1.18,0.217,14202,0.501,"MAPK14, DERL1, ALS2, BCL2L1, BAX, PPP3CB, PPP3CC, DAXX, TOMM40L, CAT, CASP3, MAP2K6, SOD1, CHP1, MAPK11, TP53, APAF1, CCS, BAD",0.66354026615147,0.300162274132754,FALSE +"HCC44","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.29309,1.09,0.25,1630,0.69,"KLRC2, CD74, HSPA6, KLRC3, HSPA1B, HSPA5, HSPA1A, IFNA1, PSME1, TAPBP, TAP2, LGMN",0.602059991327962,0.161150909262745,FALSE +"HCC44","Input","KEGG_APOPTOSIS",-0.27951,-0.818,0.799,14098,1,"PRKACA, PIK3R1, FAS, AIFM1, BCL2L1, PRKAR1A, BAX, PPP3CB, PPP3CC, PRKAR2B, TRADD, PIK3CA, CASP3, IRAK4, FADD, RELA, IKBKB, CHP1, ENDOG, PRKX, CASP6, TP53, PIK3R2, CAPN1, APAF1, BAD",0.0974532206860086,0,FALSE +"HCC44","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.17975,-0.521,0.992,17627,1,"PTGES2, PLA2G4B, LTA4H, PLA2G6, PLA2G12A",0.00348832784582135,0,FALSE +"HCC44","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.29107,-0.843,0.756,11735,1,"GLUD1, GLUD2, GOT2, PYCR1, P4HA1, GLS2, ALDH18A1, GATM, ALDH7A1, CKMT1A, CKMT1B, PRODH, NOS3, SAT2, LAP3, CPS1, SMS, PYCR2, OAT, ALDH9A1, GLUL, AZIN2, GOT1, GAMT, PYCR3",0.121478204498793,0,FALSE +"HCC44","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.20439,-0.607,0.976,9327,1,"LAMA2, SGCG, CACNA2D3, ITGA11, SGCB, CTNNA2, CTNNA1, SGCD, SGCA, CACNG7, ITGA10, CACNA1C, CACNB2, ITGA9, ACTN2, CACNA2D2, ITGA6, RYR2, DAG1, CACNG6, TCF7L2, CACNA1D, CACNB4, CACNG8, ITGA4, ITGB6, ITGA2B, SLC8A1, LMNA, CACNG4, LEF1, ITGA7, CACNA2D1, PKP2, DMD, ITGB8, EMD, CDH2, TCF7L1, CACNB3",0.0105501823333082,0,FALSE +"HCC44","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.15866,-0.459,1,16830,1,"ALDH9A1",0,0,FALSE +"HCC44","Input","KEGG_ASTHMA",0.44335,1.61,0.0678,2492,0.241,"TNF, IL13, CD40, PRG2, FCER1A",1.16877030613294,0.617982957425132,FALSE +"HCC44","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.33423,1.24,0.188,9163,0.481,"IL2, IFNA1, CD40, IFNA4, IFNA17, IFNA6, IFNA16, CD28, FASLG, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, CD80, IL10, TSHB, IFNA13, IL4, CTLA4, CD86, IFNA21, CGA, PRF1, IFNA8, GZMB, TPO, IFNA5, TSHR",0.72584215073632,0.317854923626168,FALSE +"HCC44","Input","KEGG_AXON_GUIDANCE",-0.3119,-0.905,0.626,11084,1,"EPHB1, NRAS, CXCL12, ROBO2, PLXNB1, GNAI2, EPHA3, NTN1, DPYSL5, ABLIM2, SEMA3C, EPHA6, SEMA6D, UNC5A, ARHGEF12, UNC5B, NGEF, ROBO1, FES, SLIT3, SEMA6A, EFNA2, RAC3, RHOA, EPHB4, SLIT2, CXCR4, SEMA3D, NFATC3, SEMA4A, SEMA3E, PLXNB2, EFNB3, PLXNB3, PTK2, SEMA5A, GNAI3, PAK4, EPHA1, ROBO3, CDC42, SEMA6C, MAPK1, RASA1, PAK6, NFATC4, EFNB1, PPP3CB, SEMA4D, PPP3CC, SEMA4C, SRGAP3, SEMA4G, DPYSL2, EPHA4, EPHB3, GSK3B, PAK1, EFNA4, RGS3, KRAS, LIMK2, EFNA3, CHP1, NCK2, SEMA4F, CFL1, CDK5, HRAS, MAPK3, SRGAP2",0.20342566678957,0,FALSE +"HCC44","Input","KEGG_BASAL_CELL_CARCINOMA",-0.29998,-0.885,0.654,12191,1,"HHIP, FZD8, WNT4, TCF7L2, PTCH1, FZD3, WNT10A, FZD7, AXIN2, WNT10B, GLI1, BMP4, FZD4, LEF1, DVL3, APC, FZD2, GSK3B, AXIN1, STK36, TCF7L1, DVL2, SMO, SUFU, TP53",0.184422251675733,0,FALSE +"HCC44","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.40519,-1.18,0.203,13676,0.501,"TBPL1, GTF2E1, TAF11, TAF2, TAF7, TAF9B, STON1, GTF2E2, GTF2B, TAF6, TAF10, TAF1, TAF6L, TAF5, GTF2A2",0.692503962086787,0.300162274132754,FALSE +"HCC44","Input","KEGG_BASE_EXCISION_REPAIR",-0.57625,-1.69,0.0128,12329,0.115,"NEIL1, XRCC1, APEX1, PARP2, POLD1, POLE, PCNA, LIG3, POLE4, MUTYH, FEN1, PARP3, APEX2, POLD3, SMUG1, POLD4, MPG, NEIL3, UNG, LIG1, POLL, NEIL2, OGG1, NTHL1, POLB",1.89279003035213,0.939302159646388,TRUE +"HCC44","Input","KEGG_BETA_ALANINE_METABOLISM",-0.40672,-1.18,0.213,15448,0.501,"ABAT, SMS, HADHA, EHHADH, ALDH9A1, ECHS1, HIBCH",0.671620396561262,0.300162274132754,FALSE +"HCC44","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.44375,-1.31,0.0985,13525,0.353,"HSD17B12, ELOVL2, HACD2, ACOT7, TECR, ACAA1, HADHA, SCD5, ACOX1, PECR",1.00656376950239,0.452225294612177,FALSE +"HCC44","Input","KEGG_BLADDER_CANCER",-0.31503,-0.927,0.58,14933,0.975,"MAPK1, CDK4, DAPK1, MDM2, KRAS, E2F1, E2F2, ERBB2, HRAS, TP53, MAPK3, VEGFB",0.236572006437063,0.0109953843014632,FALSE +"HCC44","Input","KEGG_BUTANOATE_METABOLISM",-0.49672,-1.44,0.0547,12914,0.223,"L2HGDH, BDH2, ALDH7A1, AACS, ACAT2, ABAT, ALDH5A1, HADHA, EHHADH, HMGCL, ALDH9A1, HMGCS1, PDHB, ECHS1, ACADS, HADH, PDHA1, ACAT1",1.26201267366657,0.651695136951839,FALSE +"HCC44","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.31521,-0.92,0.609,11376,0.975,"PIK3CB, CD81, BLNK, BCL10, VAV2, MAP2K1, AKT2, INPP5D, PIK3R3, RAC3, SOS2, IFITM1, AKT1, NFATC3, SYK, PIK3AP1, PIK3R1, LILRB3, MAPK1, VAV3, CD72, NFATC4, NFKBIE, PPP3CB, PPP3CC, PLCG2, PIK3CA, GSK3B, GRB2, KRAS, RELA, IKBKB, CHP1, SOS1, HRAS, MAPK3, PIK3R2",0.215382707367125,0.0109953843014632,FALSE +"HCC44","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.19988,-0.579,0.981,12473,1,"F2R, P2RX6, PDE1C, PRKCG, PLCD4, CAMK2B, RYR1, ATP2A1, CACNA1D, CACNA1H, PDGFRB, TBXA2R, CALML6, ADRA1B, TNNC1, CHRM3, PRKACA, CALM1, SLC8A1, CHRNA7, VDAC1, PLCB4, NOS3, GNA11, CAMK4, PHKB, GNAL, ERBB3, PPID, ITPKA, P2RX4, PHKG2, PPP3CB, PPP3CC, PLCG2, CAMK2D, ITPKB, VDAC2, ADCY9, SLC25A4, PHKA2, CAMK2G, CALM2, SLC25A6, CHP1, ERBB2, PLCD1, PLCG1, GNAQ, PRKX, SPHK2, VDAC3, CALM3, PLCB3",0.0083309926200515,0,FALSE +"HCC44","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.44629,-1.29,0.116,13704,0.362,"TNNC1, CACNB4, CACNG8, UQCRH, COX7A2, SLC8A1, TNNI3, CACNG4, CACNA2D1, UQCRC1, COX7B, SLC9A6, TPM3, COX6B1, COX7A2L, UQCRQ, UQCRFS1, UQCRC2, CYC1, UQCR11, UQCRHL, COX5A, COX7C, UQCR10, COX6A1, CACNB3, COX5B, COX6C, UQCRB, COX8A",0.935542010773082,0.441291429466834,FALSE +"HCC44","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.18511,0.695,0.92,1943,0.978,"ITGB2, CD274, PVR, ICAM1, PDCD1LG2, ICAM2, SELPLG, CLDN1, PTPRF, CD58, NEGR1, SDC4, ITGAV, ALCAM, ITGB1, CD40, CLDN4",0.0362121726544447,0.00966114521239857,FALSE +"HCC44","Input","KEGG_CELL_CYCLE",-0.50846,-1.48,0.0424,12645,0.197,"TFDP2, STAG2, DBF4, ANAPC4, ORC5, TGFB3, SKP2, RBL2, CREBBP, PTTG2, CDK7, CDC14B, ANAPC1, ORC6, MAD2L2, RBL1, CDC26, ANAPC10, CHEK2, MCM4, BUB3, HDAC1, PCNA, YWHAQ, WEE1, ZBTB17, MCM2, CDK2, CDC20, CCND3, SMC1A, MCM6, CDC14A, CDK4, YWHAH, ANAPC5, ANAPC7, SKP1, MCM3, YWHAE, GSK3B, CDKN2C, PTTG1, MDM2, CDC45, ORC2, CCNB1, MCM5, YWHAZ, CDKN1B, ANAPC11, FZR1, SMC3, CDC23, ORC3, ORC4, E2F1, TTK, ORC1, CHEK1, E2F2, CDC27, CDC25B, PLK1, CCNA2, YWHAB, BUB1, CCNB2, MAD2L1, CDKN2D, TP53, CDK1, BUB1B, ESPL1, RBX1, CDC25C, RAD21, PKMYT1",1.37263414340727,0.705533773838407,TRUE +"HCC44","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.19876,-0.584,0.975,11825,1,"ADCY5, VAV2, MAP2K1, PREX1, JAK3, PRKCD, AKT2, CXCR6, WASL, GRK7, GRK4, GNG2, GNG13, GNG5, CCL28, PIK3R3, PARD3, SHC3, CCL27, SOS2, RHOA, GNG7, GNB5, SHC2, CXCR4, AKT1, RASGRP2, CCL2, PRKACA, TIAM2, PIK3R1, RAP1A, PTK2, PLCB4, GNAI3, PRKCZ, ADCY6, CDC42, MAPK1, VAV3, CCR10, GRK5, CRKL, PIK3CA, ARRB1, GSK3B, ADCY9, STAT1, GRK2, PAK1, GRB2, KRAS, RELA, STAT2, IKBKB, GNB2, SOS1, GRK6, PRKX, ARRB2, HRAS, CSK, MAPK3, PIK3R2, PLCB3",0.0109953843014632,0,FALSE +"HCC44","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.37997,-1.1,0.295,12387,0.617,"ARAF, PTPN11, PIK3R3, SHC3, SOS2, TGFB3, CBLC, SHC2, AKT1, CTBP2, PIK3R1, HDAC1, CBL, BCR, MAPK1, BCL2L1, CDK4, CRKL, PIK3CA, GAB2, MDM2, CDKN1B, GRB2, KRAS, RELA, E2F1, IKBKB, E2F2, SOS1, CTBP1, HRAS, TP53, MAPK3, PIK3R2, BAD",0.530177984021837,0.209714835966758,FALSE +"HCC44","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.19943,-0.581,0.974,17357,1,"CRY2",0.0114410431213845,0,FALSE +"HCC44","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.52036,-1.51,0.0391,14250,0.19,"DLAT, OGDH, OGDHL, SUCLA2, IDH2, SDHB, FH, SDHD, SDHC, PDHB, IDH1, IDH3A, MDH1, ACO2, PDHA1, SUCLG1",1.40782324260413,0.721246399047171,TRUE +"HCC44","Input","KEGG_COLORECTAL_CANCER",-0.36807,-1.08,0.326,12342,0.647,"TCF7L2, ARAF, PIK3R3, CASP9, RAC3, MLH1, BCL2, TGFB3, RHOA, AXIN2, AKT1, MSH3, PIK3R1, APPL1, MAPK10, RALGDS, MSH6, MAPK1, LEF1, BAX, APC, MAPK9, PIK3CA, GSK3B, AXIN1, CASP3, TCF7L1, KRAS, BIRC5, TP53, MAPK3, PIK3R2, BAD",0.486782399932061,0.1890957193313,FALSE +"HCC44","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.43012,1.62,0.04,1345,0.276,"THBD, CFB, PLAUR, C3, F3, SERPINE1, BDKRB1, TFPI, PLAU, C1S, CD55, C4A, BDKRB2",1.39794000867204,0.559090917934782,FALSE +"HCC44","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.31599,-0.924,0.588,15274,0.974,"MTR, LDHA, SMS, ADI1, DNMT3B, DNMT3A, ENOPH1, MPST, GOT1, MAT2B",0.230622673923862,0.0114410431213845,FALSE +"HCC44","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.42205,1.6,0.0408,1980,0.216,"OSM, TNFRSF9, TNFSF11, IL24, IL11, CSF3, CXCL5, TNFRSF18, TNFRSF6B, CXCL6, TNF, CXCL8, IL2, IFNE, CSF2, CXCL2, CCL20, VEGFC, CCL5, CXCL3, IL12B, IL6, TGFB2, BMP2, TNFRSF10D, IL1B, IL15RA, TNFRSF25, IL1A, IL13, TNFRSF10A, INHBE, IL6ST, TGFBR1, CSF1, IL20RB, CCL26, CLCF1, IL6R, IL7R, TNFSF14, CD70, OSMR, CXCR3, IFNA1, XCL1, TNFSF9, TGFB1, KITLG, TNFRSF4, CX3CL1, LTB, IFNGR1, TGFBR2, EGFR, PF4V1, IL2RG, VEGFA, RELT, IL22, TNFRSF12A, MET, IL1RAP, CXCL1, CD40, IL7, IL23A",1.38933983691012,0.665546248849069,TRUE +"HCC44","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.22063,0.802,0.66,1635,0.895,"CCL5, IL6, IL1B, RIPK1, AIM2, IFNA1, NFKB1, NFKBIA, IKBKG",0.180456064458131,0.048176964684088,FALSE +"HCC44","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.16076,-0.466,0.997,9251,1,"MYL2, LAMA2, SGCG, CACNA2D3, ADCY4, ITGA11, IGF1, SGCB, TPM1, SGCD, SGCA, CACNG7, ITGA10, CACNA1C, ADRB1, CACNB2, ITGA9, CACNA2D2, ITGA6, ADCY5, RYR2, DAG1, CACNG6, TNNT2, CACNA1D, TGFB3, TNNC1, CACNB4, CACNG8, ITGA4, ITGB6, PRKACA, ITGA2B, SLC8A1, LMNA, TNNI3, CACNG4, ADCY6, ITGA7, CACNA2D1, DMD, ITGB8, EMD, ADCY9, TPM3, PRKX, CACNB3",0.00130484168834428,0,FALSE +"HCC44","Input","KEGG_DNA_REPLICATION",-0.58861,-1.74,0.00529,13452,0.103,"POLD1, POLA1, POLE, MCM4, RPA3, PCNA, MCM2, RFC4, MCM6, RFC2, POLE4, RPA2, MCM3, FEN1, RNASEH2A, POLD3, MCM5, RPA1, RFC5, POLD4, PRIM2, LIG1, DNA2, RNASEH2C, POLA2",2.27654432796481,0.987162775294828,TRUE +"HCC44","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.36954,-1.08,0.344,11539,0.647,"NOTCH4, MAP2K1, SPIRE2, NOTCH3, SOS2, FMN2, CPEB1, MAPK1, GRB2, KRAS, SOS1, MAPK3",0.46344155742847,0.1890957193313,FALSE +"HCC44","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.19587,-0.574,0.985,5790,1,"UGT2B11, GSTA3, CYP2A7, UGT2B4, CYP2A13, FMO2, ADH1B, ADH7, ADH4, UGT2B17, CYP1A2, FMO1, ADH1A, CYP3A43, UGT2A3, GSTM5, CYP2C19, UGT2B15, CYP2A6, GSTA2, FMO3, CYP2B6, ADH1C, CYP2C9, GSTK1, CYP2C18, CYP2C8, GSTA1, GSTM4, ADH6, MGST2, MAOA, CYP3A5, CYP3A7, CYP3A4, MAOB, UGT2B7, ALDH3B2, CYP2E1, CYP2D6, GSTM1, GSTM2, GSTT2, FMO5, GSTO1, GSTP1, FMO4, GSTA4, ADH5, MGST3",0.00656376950238827,0,FALSE +"HCC44","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.20452,-0.602,0.972,18592,1,"UCK1, TK1",0.0123337350737254,0,FALSE +"HCC44","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.26823,1.03,0.339,1952,0.675,"COL4A6, ITGA2, AGRN, TNXB, LAMC2, LAMB3, ITGA1, ITGA5, HSPG2, COL4A2, COL4A1, COL5A1, LAMB1, COL6A2, LAMA5, SDC4, LAMA3, COL6A1, THBS1, RELN, ITGAV, ITGB1, CD44, ITGA3",0.469800301796918,0.170696227168975,FALSE +"HCC44","Input","KEGG_ENDOCYTOSIS",-0.43834,-1.28,0.124,13127,0.375,"ITCH, CBLC, SH3GL3, CLTB, VPS37B, AP2M1, ACAP1, RAB5A, CXCR4, RAB11FIP5, RAB11FIP3, HSPA1L, CHMP2B, PIP5K1A, AP2A1, EPN3, CBL, RUFY1, PARD6G, CLTC, PDCD6IP, WWP1, DNM3, EEA1, PRKCZ, IQSEC1, RAB4A, MVB12A, CDC42, FGFR2, ERBB3, SH3GLB1, VPS4A, RAB5C, VPS37C, FGFR4, SH3GL1, GRK5, RBSN, PIP4K2B, USP8, PSD, PARD6B, EPN1, ARRB1, RAB11FIP4, CHMP4B, CHMP2A, PARD6A, MDM2, RAB11B, AGAP1, GRK2, STAM2, SH3GLB2, VPS25, STAMBP, IQSEC2, MVB12B, VPS37A, VPS37D, CLTA, PIKFYVE, RNF41, ASAP3, TSG101, SRC, GIT2, SMAP1, CHMP3, GRK6, DNM1L, GIT1, SNF8, CHMP5, ARRB2, HRAS, EPS15, ARFGAP2, PLD2, ARAP1, VPS28, RAB5B, RAB11A",0.906578314837765,0.425968732272281,FALSE +"HCC44","Input","KEGG_ENDOMETRIAL_CANCER",-0.44413,-1.27,0.134,11157,0.38,"NRAS, APC2, EGF, FOXO3, PIK3CB, MAP2K1, AKT2, TCF7L2, ARAF, PIK3R3, CASP9, MLH1, SOS2, AXIN2, AKT1, PIK3R1, MAPK1, PDPK1, LEF1, APC, PIK3CA, ELK1, GSK3B, AXIN1, TCF7L1, GRB2, KRAS, ERBB2, SOS1, ILK, HRAS, TP53, MAPK3, PIK3R2, BAD",0.872895201635192,0.42021640338319,FALSE +"HCC44","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.43152,-1.26,0.141,14005,0.387,"JAM3, MAPK14, ATP6V0D1, MAPK10, ATP6V0B, ATP6V1G1, ATP6V0A1, ATP6V1G2, CDC42, ATP6V1B1, ATP6V0E2, PLCG2, MAPK9, ADAM10, ATP6V1A, ATP6V1H, ATP6V0C, CASP3, ATP6V1B2, PAK1, RELA, ATP6V1E1, IKBKB, ATP6V0E1, ATP6V1E2, MAPK11, SRC, PLCG1, ATP6V1C1, GIT1, CSK, ATP6V1F",0.85078088734462,0.412289034981089,FALSE +"HCC44","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.39089,-1.14,0.238,12707,0.539,"PRKCG, PIK3R3, CAMK2B, SHC3, SOS2, CBLC, SHC2, AKT1, MAP2K7, PIK3R1, PTK2, MAPK10, NRG2, CBL, NRG4, PAK4, MAPK1, ERBB3, PAK6, EIF4EBP1, PLCG2, CRKL, MAPK9, CAMK2D, PIK3CA, ELK1, GSK3B, RPS6KB1, GAB1, PAK1, CDKN1B, CAMK2G, GRB2, KRAS, ERBB2, SOS1, NCK2, SRC, PLCG1, RPS6KB2, HRAS, MAPK3, PIK3R2, BAD",0.623423042943488,0.268411234813261,FALSE +"HCC44","Input","KEGG_ETHER_LIPID_METABOLISM",-0.40118,-1.18,0.211,17652,0.501,"PLA2G4B, PAFAH1B3, PLA2G6, PAFAH2, PLD2, PLA2G12A",0.675717544702307,0.300162274132754,FALSE +"HCC44","Input","KEGG_FATTY_ACID_METABOLISM",-0.53442,-1.56,0.0337,14150,0.149,"ECI1, ACADM, ACAT2, CPT1C, ACAA1, ACSL3, HADHA, EHHADH, GCDH, ALDH9A1, ECHS1, ACADS, CPT1B, ACOX1, ACADSB, HADHB, ACSL1, HADH, ADH5, ACAT1",1.47237009912866,0.826813731587726,TRUE +"HCC44","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.29177,-0.852,0.735,13644,1,"AKT1, SYK, MAP2K7, PIK3R1, MAPK14, MAPK10, MAPK1, VAV3, PDPK1, PLCG2, MAPK9, PIK3CA, GAB2, MAP2K6, GRB2, KRAS, PLA2G4B, SOS1, PLA2G6, MAPK11, PLCG1, HRAS, MAPK3, PIK3R2, PLA2G12A",0.133712660915805,0,FALSE +"HCC44","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.37069,-1.07,0.328,11163,0.66,"ARPC1A, PLA2G4F, FCGR2A, PIK3CB, WAS, DNM2, VAV2, MAP2K1, PRKCD, AKT2, WASL, SCIN, INPP5D, PRKCG, PIK3R3, MARCKSL1, MARCKS, PLPP1, AKT1, SYK, PIP5K1A, PIK3R1, VASP, ARPC4, DNM3, CDC42, MAPK1, VAV3, PLCG2, CRKL, PIP4K2B, PIK3CA, WASF2, GAB2, RPS6KB1, WASF3, PAK1, ARPC5, LIMK2, ARPC2, PIKFYVE, ASAP3, PLA2G4B, PLA2G6, PLCG1, GSN, RPS6KB2, DNM1L, SPHK2, CFL1, MAPK3, PIK3R2, PLD2, ARPC3",0.484126156288321,0.180456064458131,FALSE +"HCC44","Input","KEGG_FOCAL_ADHESION",-0.20819,-0.607,0.966,10402,1,"COL6A3, PAK3, VEGFD, XIAP, RASGRF1, CAV1, MYLK3, MAPK8, ROCK1, ITGA10, LAMC3, PTEN, ARHGAP35, COL11A1, COL5A3, PXN, MYL9, MYLK2, ITGA9, ACTN2, EGF, PIK3CB, FLT4, COL1A1, ITGA6, VAV2, MAP2K1, AKT2, THBS2, COL3A1, CCND2, LAMA1, PRKCG, PIK3R3, RAC3, SHC3, SOS2, BCL2, COL11A2, PDGFRB, RHOA, COL1A2, MYLPF, PGF, PDGFC, SHC2, AKT1, TLN1, ITGA4, SPP1, ITGB6, THBS4, ITGA2B, CHAD, PIK3R1, RAP1A, MYL5, VASP, PTK2, MAPK10, PDGFD, PPP1CC, PAK4, CDC42, PDGFB, LAMA4, MAPK1, VAV3, PDPK1, CCND3, COL5A2, PAK6, ITGA7, FN1, CRKL, MAPK9, ITGB8, THBS3, PIK3CA, ELK1, GSK3B, RAPGEF1, PAK1, GRB2, ERBB2, SOS1, ILK, SRC, TLN2, PPP1CB, HRAS, MAPK3, PIK3R2, VEGFB, PPP1CA, BAD",0.0150228735845067,0,FALSE +"HCC44","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.47339,-1.37,0.0705,14562,0.291,"GGH, QDPR, FPGS, SPR, DHFR",1.1518108830086,0.536107011014093,FALSE +"HCC44","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.48366,-1.42,0.0389,15857,0.243,"PHPT1, GMPPB, MTMR6, TPI1, PFKL, ALDOA, PMM1, KHK, GMPPA, MPI, FPGT",1.41005039867429,0.614393726401688,TRUE +"HCC44","Input","KEGG_GALACTOSE_METABOLISM",-0.44266,-1.3,0.106,11743,0.358,"GCK, PGM1, PGM2, HK1, GALE, PFKM, GALK1, B4GALT2, GAA, GLA, GALK2, PFKL, UGP2, GALT, GANC",0.97469413473523,0.446116973356126,FALSE +"HCC44","Input","KEGG_GAP_JUNCTION",-0.34838,-1.03,0.406,10956,0.753,"DRD2, ADRB1, NRAS, EGF, TUBB8, GNAI2, GUCY1A2, ADCY5, TUBB2A, MAP2K1, PRKG1, PRKCG, GUCY1A1, SOS2, PDGFRB, PDGFC, TUBB4A, TUBA1A, PRKACA, PDGFD, GUCY1B1, PLCB4, GNAI3, TUBB2B, GNA11, ADCY6, PDGFB, MAPK1, MAP3K2, TUBB4B, TUBB, MAPK7, TUBA1B, ADCY9, GRB2, KRAS, SOS1, SRC, MAP2K5, GNAQ, PRKX, HRAS, CDK1, MAPK3, PLCB3",0.391473966422806,0.123205023799299,FALSE +"HCC44","Input","KEGG_GLIOMA",-0.39728,-1.17,0.221,11127,0.494,"RB1, NRAS, EGF, PIK3CB, MAP2K1, MTOR, AKT2, ARAF, PRKCG, PIK3R3, CAMK2B, SHC3, SOS2, PDGFRB, SHC2, CALML6, AKT1, PIK3R1, CALM1, PDGFB, MAPK1, CDK4, PLCG2, CAMK2D, PIK3CA, MDM2, CAMK2G, GRB2, KRAS, E2F1, CALM2, E2F2, SOS1, PLCG1, HRAS, TP53, MAPK3, PIK3R2, CALM3",0.655607726314889,0.306273051076353,FALSE +"HCC44","Input","KEGG_GLUTATHIONE_METABOLISM",-0.28621,-0.827,0.754,12431,1,"GPX7, GSTM2, GPX2, OPLAH, GPX4, GSTT2, GSTO1, RRM1, LAP3, IDH2, GSTP1, TXNDC12, SMS, RRM2, GSS, IDH1, RRM2B, GSTA4, MGST3",0.122628654130226,0,FALSE +"HCC44","Input","KEGG_GLYCEROLIPID_METABOLISM",0.26218,0.96,0.48,1263,0.768,"GPAT2, AKR1B1, DGKH, GPAT3, PLPP3, DGKG, DGKE, DGAT2, DGKD, GK, DGKI",0.318758762624413,0.114638779968488,FALSE +"HCC44","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.28063,-0.821,0.768,11448,1,"GPD1, PHOSPHO1, AGPAT3, CHKA, PLA2G10, PCYT1A, PCYT1B, LPCAT3, CDS1, PGS1, LCLAT1, PLPP1, LPCAT4, GPD2, PLA2G15, AGPAT2, ACHE, MBOAT1, ETNK1, LYPLA1, PTDSS2, DGKZ, GNPAT, LPGAT1, DGKQ, ETNK2, DGKA, CHKB, PLA2G4B, PLA2G6, PCYT2, CDS2, LYPLA2, PLD2, PLA2G12A, CDIPT",0.114638779968488,0,FALSE +"HCC44","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.28303,-0.826,0.773,10800,1,"MAOA, MAOB, SHMT2, GNMT, SARDH, DLD, PSPH, PIPOX, GCAT, GATM, GLYCTK, SRR, GLDC, AMT, PHGDH, ALAS1, SHMT1, GAMT",0.111820506081675,0,FALSE +"HCC44","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.4332,-1.27,0.122,13390,0.38,"PGK1, ALDH7A1, PFKM, DLAT, BPGM, GALM, PGAM4, GPI, GAPDH, LDHA, AKR1A1, ENO3, TPI1, ALDH9A1, ACSS1, PKM, PDHB, PFKL, ALDOA, ACSS2, PGAM1, PDHA1, ADH5",0.913640169325252,0.42021640338319,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.33629,1.3,0.0377,750,0.414,"CSGALNACT1, CHSY1, B3GALT6, CHST11, CHPF2, DSE",1.42365864979421,0.382999658879101,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.25001,-0.729,0.883,11027,1,"NDST3, B3GAT1, GLCE, EXT2, HS3ST3A1, NDST1, XYLT1, HS3ST3B1, EXTL3, B4GALT7, HS6ST1, XYLT2, NDST2, B3GAT3",0.0540392964224314,0,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.29609,-0.866,0.698,13130,1,"B3GNT7, CHST6, B4GALT2, B4GALT3, B4GAT1, B4GALT4",0.156144577376839,0,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.34584,-1.01,0.438,11770,0.806,"IDUA, HYAL1, HS3ST3A1, HYAL2, HS3ST3B1, HEXB, GALNS, HYAL3",0.3585258894959,0.0936649581949093,FALSE +"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.26843,1.04,0.441,13985,0.73,"ST3GAL1, SLC33A1, ST3GAL2, GLB1, ST6GALNAC4, ST3GAL5, HEXA, ST8SIA5, ST6GALNAC6, B4GALNT1, ST6GALNAC5, ST6GALNAC3, ST8SIA1, B3GALT4, HEXB",0.355561410532161,0.136677139879544,FALSE +"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.27799,-0.813,0.808,10376,1,"FUT9, FUT2, FUT1, GBGT1, ST8SIA1, HEXB, GLA, NAGA",0.0925886392254138,0,FALSE +"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.21628,-0.637,0.97,9786,1,"B3GNT2, B3GALT2, FUT9, ST3GAL6, FUT2, FUT1, ABO, B3GALT1, FUT3, ST8SIA1, B4GALT2, B3GNT4, B4GALT3, B4GAT1, B4GALT4",0.0132282657337552,0,FALSE +"HCC44","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.53049,-1.57,0.0149,12054,0.145,"PIGB, PIGP, PIGZ, PIGN, PIGT, PIGA, PIGG, PIGK, PIGO, GPLD1, DPM2, PGAP1, PIGM, PIGF, PIGQ, PIGC, PIGV, PIGU, GPAA1",1.82681373158773,0.838631997765025,TRUE +"HCC44","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.4592,-1.36,0.0791,12685,0.293,"AFMID, ACO1, GLYCTK, CS, GRHPR, PGP, MDH1, ACO2",1.10182351650232,0.533132379645891,FALSE +"HCC44","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.40387,-1.19,0.189,13640,0.51,"CALML6, ATF4, MAP2K7, PRKACA, MAPK14, MAPK10, CALM1, PLCB4, GNA11, MAP3K1, ADCY6, CDC42, MAPK1, MAP3K2, MAPK9, CAMK2D, MAP3K3, MAPK7, ELK1, ADCY9, GNRH1, MAP2K6, CAMK2G, GRB2, KRAS, CALM2, PLA2G4B, SOS1, PLA2G6, MAPK11, SRC, GNAQ, PRKX, HRAS, MAPK3, PLD2, CALM3, PLA2G12A, PLCB3",0.723538195826756,0.292429823902064,FALSE +"HCC44","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.6556,2.61,0,565,0.0206,"TNF, IL2, IL6, IL1B, IL1A",Inf,1.68613277963085,TRUE +"HCC44","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.2018,-0.595,0.979,12191,1,"HHIP, WNT4, PTCH1, CSNK1G2, WNT10A, CSNK1G3, GAS1, WNT10B, BMP7, GLI1, PRKACA, BMP4, FBXW11, CSNK1G1, GSK3B, STK36, SMO, PRKX, BTRC, SUFU",0.00921730819686218,0,FALSE +"HCC44","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.41787,1.74,0.0182,1254,0.22,"IL11, CSF3, CD38, TNF, CSF2, ITGA2, IL6, IL1B, IL1A, ITGA1, CSF1, ITGA5, IL6R, IL7R, CD55, KITLG, TFRC",1.73992861201493,0.657577319177794,TRUE +"HCC44","Input","KEGG_HISTIDINE_METABOLISM",-0.28659,-0.831,0.753,10163,1,"AMDHD1, AOC1, MAOA, MAOB, ALDH3B2, ACY3, FTCD, ALDH7A1, LCMT2, ALDH9A1, HEMK1, LCMT1",0.123205023799299,0,FALSE +"HCC44","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.64738,-1.89,0.00107,15780,0.0903,"BRCA2, RAD52, RPA2, MRE11, POLD3, RPA1, POLD4, RAD51C, EME1, BLM, RAD54L, MUS81, RAD51, RAD54B, SEM1",2.97061622231479,1.04431224968649,TRUE +"HCC44","Input","KEGG_HUNTINGTONS_DISEASE",-0.57084,-1.68,0.00536,16086,0.106,"NDUFA9, NDUFS4, COX7B, POLR2E, CREB1, NDUFV2, ATP5PF, VDAC2, NDUFS5, CASP3, SLC25A4, NDUFA3, ATP5PB, POLR2J, NDUFB9, SDHD, SOD1, SDHC, COX6B1, COX7A2L, POLR2F, UQCRQ, CLTA, UQCRFS1, CREB3L4, UQCRC2, CYC1, DCTN2, SLC25A6, NDUFB7, NDUFB1, UQCR11, POLR2K, ATP5PD, UQCRHL, ATP5F1E, NDUFA8, GNAQ, COX5A, DNAL4, NDUFA4, NDUFA10, NDUFS8, CREB3, NDUFS2, COX7C, POLR2G, NDUFV1, NDUFB8, VDAC3, NDUFB4, TP53, NDUFC2, ATP5F1C, DCTN1, POLR2L, SP1, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, COX6A1, PLCB3, NDUFA2, NDUFS3, SIN3A, APAF1, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, UQCRB, COX8A, NDUFB3",2.27083521030723,0.97469413473523,TRUE +"HCC44","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.17222,0.68,0.931,1065,0.91,"CACNA2D4, TNF, ITGA2, IL6, TGFB2, ITGA1, ITGA5, TPM4, TGFB1",0.0310503190186574,0.0409586076789064,FALSE +"HCC44","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.47716,-1.4,0.0771,14947,0.258,"PIP4K2C, INPP5K, ITPKA, PLCG2, INPP4B, PIP4K2B, PI4KB, ITPKB, IPMK, PIK3CA, PI4KA, INPP5E, TPI1, PIKFYVE, INPPL1, INPP4A, PIK3C2B, PLCD1, PLCG1, CDIPT, PLCB3, INPP5B",1.11294562194904,0.58838029403677,FALSE +"HCC44","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.42708,-1.26,0.136,11029,0.387,"PDE3A, RPTOR, NRAS, PRKAB2, FBP2, PRKAB1, PIK3CB, PRKCI, SLC2A4, GCK, MAP2K1, MTOR, SH2B2, AKT2, PRKAR2A, ARAF, INPP5D, PIK3R3, PPP1R3D, HK1, SHC3, SOS2, PDE3B, CBLC, FLOT2, INSR, TRIP10, FASN, SHC2, CALML6, AKT1, ACACB, TSC1, PPARGC1A, PRKACA, PIK3R1, MAPK10, CALM1, SORBS1, CBL, PPP1CC, LIPE, PHKB, PRKCZ, MAPK1, PDPK1, PRKAR1A, INPP5K, EIF4EBP1, EIF4E, PHKG2, PRKAR2B, CRKL, TSC2, MAPK9, PIK3CA, ELK1, FLOT1, GSK3B, RPS6KB1, MKNK1, RAPGEF1, PHKA2, GRB2, GYS1, KRAS, CALM2, PTPN1, IKBKB, EXOC7, SOS1, RPS6KB2, PRKX, PPP1CB, HRAS, PRKAG1, MAPK3, PIK3R2, CALM3, EIF4E2, PPP1CA, BAD",0.866461091629782,0.412289034981089,FALSE +"HCC44","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.26305,1.01,0.386,1065,0.69,"IL2, IL6, IL15RA, MAP3K14, TGFB1",0.413412695328245,0.161150909262745,FALSE +"HCC44","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.30773,1.17,0.213,1020,0.546,"OSM, IL24, IL11, CSF3, IL2, IFNE, CSF2, SPRY2, IL12B, IL6, MYC, IL15RA, IL13, IL6ST, SPRY4, IL20RB, SOCS4, CLCF1, SOCS3, IL6R, SPRED1, IL7R, OSMR, IFNA1",0.671620396561262,0.262807357295263,FALSE +"HCC44","Input","KEGG_LEISHMANIA_INFECTION",0.39455,1.41,0.06,1864,0.331,"NCF2, ITGB2, PTGS2, TNF, C3, IL12B, TGFB2, IL1B, IL1A, FOS, TLR2, CYBA, TGFB1, NFKB1, IFNGR1, NFKBIA, JUN, ITGB1",1.22184874961636,0.480172006224281,FALSE +"HCC44","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.18632,0.704,0.84,1058,0.998,"ITK, NCF2, ITGB2, ICAM1, ARHGAP5, MYL12A, CLDN1, RAC2, CYBA, VCL",0.0757207139381184,0.000869458712628891,FALSE +"HCC44","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.59875,-1.76,0.00624,15905,0.1,"HADHA, EHHADH, ALDH9A1, ECHS1, NAA80",2.20481541031758,1,TRUE +"HCC44","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.28516,-0.824,0.772,17652,1,"PLA2G4B, PLA2G6, PLA2G12A",0.112382699664264,0,FALSE +"HCC44","Input","KEGG_LONG_TERM_DEPRESSION",-0.31732,-0.937,0.559,11495,0.965,"GNAI2, GUCY1A2, PLA2G10, MAP2K1, CACNA1A, ARAF, PRKG1, PRKCG, GUCY1A1, RYR1, GNAO1, GUCY1B1, PPP2CB, PLCB4, GNAI3, GNA11, MAPK1, PPP2R1B, GNAZ, PPP2CA, PPP2R1A, KRAS, PLA2G4B, PLA2G6, GNAQ, HRAS, MAPK3, PLA2G12A, PLCB3",0.252588192113577,0.0154726866562074,FALSE +"HCC44","Input","KEGG_LONG_TERM_POTENTIATION",-0.40745,-1.19,0.181,13640,0.51,"CALML6, ATF4, RPS6KA6, PRKACA, RAP1A, CALM1, PLCB4, PPP1CC, RAPGEF3, CAMK4, MAPK1, PPP3CB, PPP3CC, CAMK2D, RPS6KA1, CAMK2G, KRAS, CALM2, CHP1, GNAQ, PRKX, PPP1CB, HRAS, MAPK3, CALM3, PPP1CA, PLCB3",0.742321425130815,0.292429823902064,FALSE +"HCC44","Input","KEGG_LYSINE_DEGRADATION",-0.50729,-1.5,0.0337,11803,0.186,"KMT5B, NSD1, SUV39H2, SETDB1, PIPOX, PLOD1, ALDH7A1, SETDB2, OGDH, SETD1A, ACAT2, OGDHL, AASDHPPT, KMT5A, NSD2, HADHA, EHHADH, GCDH, EHMT1, SETD1B, AADAT, KMT5C, ALDH9A1, NSD3, AASDH, ECHS1, EHMT2, SUV39H1, HADH, ACAT1",1.47237009912866,0.730487055782084,TRUE +"HCC44","Input","KEGG_LYSOSOME",-0.38981,-1.14,0.244,13233,0.539,"SLC11A1, CLTB, AP3B2, GNPTG, ENTPD4, ACP2, PLA2G15, MCOLN1, ABCA2, GGA3, HEXB, AP1M1, ATP6V0D1, ATP6V0B, AP1S1, CLN3, GNPTAB, AP4E1, ATP6V0A1, SORT1, CLTC, AP3S1, AP1S2, AP4B1, NPC2, AP3B1, CTSA, GM2A, SCARB2, GAA, CTSH, GGA2, ATP6V1H, ATP6V0C, GLA, GGA1, AP1M2, GALNS, ARSA, SMPD1, LAPTM4A, AP3M2, CLTA, GALC, AP1B1, ASAH1, SLC17A5, AP3M1, SLC11A2, AP4M1, CTSV, AP3S2, ABCB9, NAGA",0.612610173661271,0.268411234813261,FALSE +"HCC44","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.2661,-0.784,0.82,12927,1,"RAC3, CACNA1D, SOS2, CACNA1H, TGFB3, MAPT, PDGFRB, RASGRF2, FGF1, MAP4K1, RRAS, AKT1, ATF4, CACNB4, CACNG8, DUSP9, RASGRP2, HSPA1L, RAPGEF2, MAP2K7, RPS6KA6, PRKACA, MAPK14, RAP1A, FGF13, MAPK10, FAS, RPS6KA4, FGF12, DDIT3, CACNG4, MAP3K13, MAP3K1, FGF11, LAMTOR3, DUSP3, CDC42, PDGFB, MAPK8IP1, MAPK1, MAP3K2, RASA1, FGFR2, MAP3K6, NFATC4, MAPK8IP2, CACNA2D1, PPP3CB, FGFR4, STMN1, PPP3CC, CRKL, HSPB1, DAXX, MAPK9, MAP3K3, RPS6KA1, DUSP14, MAPK7, MAX, ARRB1, ELK1, CASP3, MAP2K6, STK4, MKNK1, PAK1, GRB2, KRAS, RELA, IKBKB, TAOK2, PLA2G4B, CHP1, CDC25B, SOS1, PLA2G6, MAP3K12, MAPK11, MAP2K5, TAOK3, PRKX, MAP3K11, ATF2, STK3, ARRB2, HRAS, TP53, MAPK3, PLA2G12A, PPM1B, TAB1, CACNB3, MAP4K2",0.0861861476162833,0,FALSE +"HCC44","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26932,0.919,0.507,11955,0.834,"BHLHA15, HHEX, PAX4, NEUROD1, NEUROG3, IAPP, PKLR, INS, FOXA3, HNF4G, SLC2A2, HNF4A, HNF1A, PDX1, ONECUT1, HES1, MAFA, MNX1, HNF1B, GCK, FOXA2, NR5A2",0.294992040666664,0.0788339493622613,FALSE +"HCC44","Input","KEGG_MELANOGENESIS",-0.3308,-0.972,0.508,11495,0.897,"GNAI2, WNT7A, KIT, WNT6, ADCY5, MAP2K1, FZD8, WNT4, TCF7L2, FZD3, PRKCG, CAMK2B, WNT10A, FZD7, CREBBP, GNAO1, CALML6, WNT10B, PRKACA, CALM1, PLCB4, GNAI3, FZD4, ADCY6, MAPK1, LEF1, DVL3, FZD2, CAMK2D, CREB1, GSK3B, ADCY9, TCF7L1, CAMK2G, KRAS, DVL2, CALM2, CREB3L4, GNAQ, PRKX, CREB3, HRAS, MAPK3, CALM3, PLCB3",0.294136287716081,0.0472075569559079,FALSE +"HCC44","Input","KEGG_MELANOMA",-0.27923,-0.829,0.757,13205,1,"PDGFRB, FGF1, PDGFC, AKT1, PIK3R1, FGF13, PDGFD, FGF12, FGF11, PDGFB, MAPK1, CDK4, PIK3CA, MDM2, KRAS, E2F1, E2F2, HRAS, TP53, MAPK3, PIK3R2, BAD",0.120904120499927,0,FALSE +"HCC44","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.1842,-0.534,0.991,18060,1,"GSTA4, ADH5, MGST3",0.00392634551472468,0,FALSE +"HCC44","Input","KEGG_MISMATCH_REPAIR",-0.59309,-1.72,0.00426,12953,0.0972,"MLH1, POLD1, MSH3, RPA3, PCNA, MSH6, EXO1, RFC4, RFC2, RPA2, POLD3, RPA1, RFC5, POLD4, PMS2, LIG1",2.37059040089728,1.01233373507373,TRUE +"HCC44","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.38148,-1.12,0.263,12016,0.577,"MTOR, AKT2, EIF4B, STK11, PIK3R3, PGF, AKT1, ULK3, TSC1, RPS6KA6, PIK3R1, MAPK1, PDPK1, EIF4EBP1, EIF4E, TSC2, RPS6KA1, PIK3CA, RPS6KB1, ULK1, RPS6KB2, STRADA, MLST8, MAPK3, PIK3R2, VEGFB, EIF4E2",0.580044251510242,0.238824186844269,FALSE +"HCC44","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.21614,0.772,0.783,1373,0.92,"SH2D1B, ITGB2, KLRC2, TNF, CSF2, ICAM1, ICAM2, TNFRSF10D, TNFRSF10A, RAET1E, KLRC3, RAC2, IFNA1, ULBP2, ULBP3, IFNGR1, LAT",0.106238237942057,0.0362121726544447,FALSE +"HCC44","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.17276,0.684,0.873,14215,0.96,"GLP2R, PTGER2, SSTR1, P2RY11, ADRA2B, P2RX5, CHRNA9, ADORA2B, GABRE, HTR7, HRH1, NR3C1, BDKRB1, CHRNA10, GHSR, S1PR3, LHB, F2RL1, BDKRB2, PRSS3, HTR2C, TRPV1, PTGER4, GCGR, GLRB, LHCGR, P2RY13, MC1R, GALR2, PLG, LTB4R, ADRB2, CALCR, GIPR, LEPR, P2RY6, AVPR2, GRIN2D, C3AR1, C5AR1, LTB4R2, LPAR2, PTGDR, P2RY14, GLRA1, GRIN1, P2RX1, TAAR2, CHRNA1, TAAR5, NPBWR2, GPR156, HTR1A, CHRNB3, HTR5A, TAAR6, LPAR1, P2RY1, TAAR8, CSH1, SSTR4, GALR1, CHRM2, HTR1D, SSTR3, FSHB, AGTR2, PRLHR, GABRA6, TAAR9, CHRNA2, MAS1, BRS3, HTR4, ADRB3, GH2, ADORA2A, RXFP2, TACR1, THRB, NTSR2, CNR2, GLRA2, F2RL3, OPRM1, GLRA3, DRD3, CHRNA3, GRM1, LEP, ADRA1A, GZMA, GRIK1, MTNR1B, HTR2B, CCKAR, NPY2R, GABRG1, TAAR1, P2RX3, GRM6, MC2R, FSHR, CYSLTR2, HTR1E, CHRND, GABRA1, PRL, FPR1, P2RY10, P2RX2, GH1, NPY4R, HCRTR1, APLNR, TSHB, HCRTR2, GABRA4, GLP1R, GPR50, GABRB2, FPR3, OPRK1, CHRM5, F2, DRD5, RXFP1, MC3R, CCKBR, FPR2, HTR1F, AVPR1A, CRHR2, S1PR4, GRM7, AVPR1B, TACR3, HRH3, ADCYAP1R1, HTR2A, GABRR2, NPY5R, GRM5, NMUR2, ADRA1D, CGA, CHRNB4, CHRNG, CYSLTR1, VIPR2, GRIA1, HTR6, UTS2R, NPFFR1, GABRA5, GRM3, GRIK3, KISS1R, P2RY8, CRHR1, NMUR1, HTR1B, CHRNA4, GRM2, PTGER3, GHRHR, CHRNA6, GABRR1, PRSS1, CHRNB2, MC5R, P2RY4, F2RL2, NPBWR1, ADORA3, MC4R, MCHR2, AGTR1, MCHR1, PRSS2, GABRB1, OXTR, GABRG3, GRIA2, TRHR, SCTR, GRIK5, P2RY2, EDNRA, EDNRB, TSHR, CHRM1, GRID2, DRD1, CTSG, PTGER1, CNR1, GRM4, GRIN3A, GRIA4, OPRD1, GRIA3, GRM8, TSPO, NTSR1, GRPR, GABRA2, GABRP, PTGIR, LPAR4, GRIN2A, GRIN2B, PTH2R, NPFFR2, HRH2, MLNR, MTNR1A, SSTR2, GPR83, SSTR5, ADRA2A, GABRG2, GNRHR, TACR2, PRLR, NPY1R, GRIK4, DRD2, ADRB1, GABRD, P2RX7, GALR3, NMBR, PTGFR, CHRM4, GABBR2, CALCRL, GRIN2C, GRID1, GRIN3B, GABRQ, PTH1R, PTAFR, GABRB3, GHR, F2R, GRIK2, P2RX6, CHRNE, GPR35, PARD3, HRH4, S1PR1, CHRNA5, TBXA2R, ADRA1B, LPAR3, DRD4, CHRM3, VIPR1, GABRA3, ADRA2C, LPAR6, OPRL1",0.0589857562944303,0.0177287669604316,FALSE +"HCC44","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.44127,-1.29,0.113,12681,0.362,"RIPK2, PIK3R3, CAMK2B, SHC3, SOS2, BCL2, RHOA, NGFR, SHC2, CALML6, AKT1, ATF4, MAP2K7, RPS6KA6, MAGED1, PIK3R1, MAPK14, RAP1A, MAPK10, KIDINS220, CALM1, RPS6KA4, YWHAQ, SORT1, MAP3K1, CAMK4, CDC42, ARHGDIB, MAPK1, PDPK1, TP73, NFKBIE, BAX, YWHAH, PLCG2, CRKL, MAPK9, CAMK2D, MAP3K3, RPS6KA1, MAPK7, PIK3CA, SH2B1, YWHAE, GSK3B, PRDM4, GAB1, IRAK4, RAPGEF1, YWHAZ, ARHGDIA, CAMK2G, GRB2, KRAS, RELA, CALM2, IKBKB, SOS1, MAPK11, PLCG1, MAP2K5, YWHAB, HRAS, TP53, CSK, MAPK3, PIK3R2, CALM3, BAD",0.94692155651658,0.441291429466834,FALSE +"HCC44","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.42565,1.52,0.146,1602,0.252,"CD38, NAMPT, PNP, NT5E, NADK, NNMT, BST1, AOX1",0.835647144215563,0.598599459218456,FALSE +"HCC44","Input","KEGG_NITROGEN_METABOLISM",-0.21551,-0.634,0.952,9246,1,"CA14, CA7, CA3, CA9, GLUD1, GLUD2, GLS2, CA13, AMT, CPS1, GLUL, CA5B",0.0213630516155257,0,FALSE +"HCC44","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.22184,0.81,0.817,1146,0.913,"TNF, CXCL8, CXCL2, CCL5, IL6, IL1B, TNFAIP3, BIRC3, NFKB1",0.0877779434675845,0.039529222465701,FALSE +"HCC44","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.67389,-1.98,0.00105,14399,0.0613,"RAD50, DCLRE1C, MRE11, FEN1, XRCC6, XRCC4, XRCC5, POLL, NHEJ1",2.97881070093006,1.21253952548158,TRUE +"HCC44","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.39943,-1.17,0.208,11127,0.494,"RB1, NRAS, EGF, FOXO3, PIK3CB, MAP2K1, AKT2, ARAF, PRKCG, PIK3R3, CASP9, SOS2, RARB, AKT1, RXRA, PIK3R1, MAPK1, PDPK1, CDK4, PLCG2, PIK3CA, STK4, GRB2, RXRB, KRAS, E2F1, E2F2, ERBB2, SOS1, PLCG1, HRAS, TP53, MAPK3, PIK3R2, BAD",0.681936665037238,0.306273051076353,FALSE +"HCC44","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.37977,-1.12,0.282,12365,0.577,"DTX4, DLL3, ADAM17, NOTCH3, DTX1, CREBBP, DLL1, CTBP2, HDAC1, PSENEN, RBPJ, DTX2, MAML2, DVL3, KAT2B, PSEN2, DVL2, APH1A, RFNG, CTBP1, CIR1",0.549750891680639,0.238824186844269,FALSE +"HCC44","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.56433,-1.65,0.0127,13330,0.109,"CDK7, ERCC1, POLD1, ERCC4, POLE, RAD23B, RPA3, PCNA, CETN2, RFC4, RFC2, POLE4, ERCC5, RPA2, CUL4B, XPA, POLD3, RPA1, ERCC6, RFC5, POLD4, GTF2H5, LIG1, XPC, ERCC3, DDB1, RBX1, DDB2",1.89619627904404,0.962573502059376,TRUE +"HCC44","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.29312,-0.858,0.724,11502,1,"TUSC3, MGAT5, ALG6, MGAT5B, MGAT1, MAN1C1, ALG8, ALG1, MGAT3, DPAGT1, B4GALT2, DPM2, B4GALT3, ALG12, MAN1B1, ALG10B, RPN2, MGAT4A, ALG14, ALG10, DPM1, DPM3",0.140261433802853,0,FALSE +"HCC44","Input","KEGG_OLFACTORY_TRANSDUCTION",0.22342,0.847,0.571,9653,0.862,"OR4F16, OR2K2, OR5B21, OR4F3, OR2B6, OR2A7, OR13H1, OR2A42, OR13A1, CNGA3, OR4F17, OR1N1, OR2A12, CNGB1, OR2A1, OR51M1, OR51I2, OR6C6, OR52J3, OR4C16, OR10AD1, OR51I1, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR51E2, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR51B4, OR2AE1, OR5AK2, CLCA1, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, CALML5, OR2V2, OR56A3, OR10H2, OR52B2, OR1B1, OR2L3, OR8D1, OR11H6, PDC, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5M11, OR13G1, PRKACB, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR52D1, OR5P3, OR52N2, OR8S1, OR2AT4, OR9A2, OR51Q1, OR13D1, OR10H1, OR8D2, OR2T33, OR1J2, OR2S2, OR2A5, OR52H1, CALML3, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, OR2T8, ADCY3, OR4D1, OR2C1, OR8G1, OR4F15, OR52B6, OR2A25, OR2D3, OR1Q1, OR8A1, OR2B2, OR1K1, OR2J3, CLCA2, OR10A6, OR2A2, OR8G5, OR11H4, OR10A4, GUCY2D, OR2L2, OR6B2, OR2D2, PRKG2, OR2AG1, OR10A3, OR10A2, OR7D2, OR2A14, OR13J1",0.243363891754152,0.0644927341752872,FALSE +"HCC44","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.53347,-1.58,0.0244,15010,0.149,"AMT, MTR, MTHFS, SHMT1, MTHFR, MTFMT, DHFR",1.61261017366127,0.826813731587726,TRUE +"HCC44","Input","KEGG_OOCYTE_MEIOSIS",-0.53935,-1.57,0.0158,13899,0.145,"MAD2L2, CDC26, ANAPC10, RPS6KA6, PRKACA, CPEB1, PPP2CB, CALM1, YWHAQ, FBXW11, PPP1CC, ADCY6, MAPK1, CDK2, CDC20, PPP2R1B, SMC1A, PPP3CB, YWHAH, PPP3CC, ANAPC5, ANAPC7, CAMK2D, SKP1, RPS6KA1, STAG3, PPP2R5A, YWHAE, ADCY9, PTTG1, FBXO43, PPP2CA, CCNB1, PPP2R1A, YWHAZ, CAMK2G, ANAPC11, SMC3, CDC23, CALM2, SGO1, CDC27, CHP1, PLK1, PRKX, YWHAB, BUB1, CCNB2, MAD2L1, BTRC, PPP1CB, CDK1, PPP2R5B, MAPK3, ESPL1, RBX1, CALM3, PPP1CA, CDC25C, PKMYT1, PPP2R5D",1.80134291304558,0.838631997765025,TRUE +"HCC44","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.26845,1.03,0.323,13985,0.675,"FUCA2, FUCA1, MANBA, GLB1, MAN2B1, NEU1, MAN2B2, NEU4, NEU2, HEXA, AGA, GBA, MAN2C1, NEU3, ENGASE, HEXB",0.490797477668897,0.170696227168975,FALSE +"HCC44","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.63494,-1.85,0.00317,16086,0.0636,"NDUFA9, NDUFS4, COX7B, ATP6V1A, NDUFV2, ATP5PF, ATP6V1H, ATP6V0C, NDUFS5, NDUFA3, ATP6V1B2, ATP5PB, NDUFB9, SDHD, SDHC, COX6B1, COX7A2L, UQCRQ, UQCRFS1, ATP6V1E1, UQCRC2, ATP6V0E1, CYC1, ATP6V1E2, NDUFB7, NDUFB1, UQCR11, ATP5PD, UQCRHL, ATP5F1E, ATP6V1C1, NDUFA8, COX5A, NDUFA4, NDUFA10, NDUFS8, NDUFS2, COX7C, NDUFV1, ATP5MG, NDUFB8, NDUFB4, NDUFC2, ATP5F1C, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, ATP5ME, COX6A1, NDUFA2, ATP6V1F, NDUFS3, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, COX15, UQCRB, COX8A, NDUFB3",2.49894073778225,1.19654288435159,TRUE +"HCC44","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.2893,1.04,0.347,1723,0.73,"GALNT14, GALNT18, GALNT5, GALNT3, GCNT4, ST3GAL1, ST3GAL2, GALNT6",0.459670525209126,0.136677139879544,FALSE +"HCC44","Input","KEGG_P53_SIGNALING_PATHWAY",-0.45955,-1.34,0.0875,13819,0.32,"PPM1D, CHEK2, SHISA5, FAS, BBC3, CDK2, EI24, CCND3, TP73, CDK4, BAX, TSC2, SESN3, SESN1, MDM2, RRM2, CASP3, CCNB1, RCHY1, GTSE1, PIDD1, CHEK1, TP53I3, COP1, RRM2B, CCNB2, CCNG2, TP53, CDK1, DDB2, APAF1",1.05799194697769,0.494850021680094,FALSE +"HCC44","Input","KEGG_PANCREATIC_CANCER",-0.35801,-1.06,0.351,14157,0.672,"PIK3R1, MAPK10, RALGDS, CDC42, MAPK1, BCL2L1, CDK4, MAPK9, BRCA2, PIK3CA, RALBP1, STAT1, KRAS, RELA, E2F1, IKBKB, E2F2, ERBB2, RALB, TP53, MAPK3, PIK3R2, VEGFB, RAD51, BAD",0.454692883534176,0.172630726946175,FALSE +"HCC44","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.26331,-0.767,0.851,15876,1,"PPCS, COASY, PPCDC",0.0700704399154121,0,FALSE +"HCC44","Input","KEGG_PARKINSONS_DISEASE",-0.62627,-1.82,0.0042,16086,0.0705,"NDUFA9, NDUFS4, COX7B, NDUFV2, ATP5PF, VDAC2, NDUFS5, CASP3, SLC25A4, NDUFA3, ATP5PB, NDUFB9, SDHD, SDHC, COX6B1, COX7A2L, UQCRQ, UQCRFS1, UQCRC2, CYC1, SLC25A6, HTRA2, NDUFB7, NDUFB1, UQCR11, UBE2L3, ATP5PD, UQCRHL, ATP5F1E, NDUFA8, COX5A, NDUFA4, NDUFA10, NDUFS8, NDUFS2, COX7C, UBA1, NDUFV1, NDUFB8, VDAC3, NDUFB4, NDUFC2, ATP5F1C, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, COX6A1, NDUFA2, NDUFS3, APAF1, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, UQCRB, COX8A, NDUFB3",2.3767507096021,1.1518108830086,TRUE +"HCC44","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.32696,-0.958,0.535,13176,0.932,"TLR5, RHOA, TLR4, TUBB4A, CTTN, TUBA1A, YWHAQ, ARPC4, TUBB2B, CDC42, TUBB4B, TUBB, TUBA1B, YWHAZ, ARPC5, ARPC2, NCK2, ARPC3",0.271646217978772,0.0305840876460186,FALSE +"HCC44","Input","KEGG_PATHWAYS_IN_CANCER",-0.24669,-0.725,0.899,12842,1,"WNT10A, TFG, CASP9, RAC3, MLH1, FZD7, SOS2, BCL2, TGFB3, SKP2, CBLC, PDGFRB, CREBBP, RHOA, FGF1, PGF, RARB, CSF2RA, AXIN2, AKT1, CKS1B, WNT10B, DAPK2, RXRA, CCDC6, GLI1, CTBP2, MSH3, ITGA2B, PIK3R1, APPL1, HDAC1, PTK2, FGF13, MAPK10, BMP4, FAS, RALGDS, CBL, FGF12, MSH6, TRAF5, FGF11, FZD4, BCR, CDC42, PDGFB, LAMA4, MAPK1, BCL2L1, CDK2, FGFR2, LEF1, CDK4, BAX, DVL3, APC, FN1, DAPK1, PLCG2, CRKL, FZD2, MAPK9, GSTP1, BRCA2, NCOA4, FH, MAX, PIK3CA, RALBP1, GSK3B, AXIN1, MDM2, CASP3, STAT1, STK36, TPM3, TCF7L1, STK4, PIAS3, CDKN1B, ELOC, FADD, GRB2, RXRB, KRAS, BIRC5, DVL2, RELA, E2F1, SMO, IKBKB, PIAS1, E2F2, PML, ERBB2, SOS1, EGLN2, PLCG1, RALB, ARNT, CTBP1, SUFU, HRAS, TP53, MAPK3, PIK3R2, RBX1, VEGFB, ELOB, RAD51, BAD",0.0462403082667712,0,FALSE +"HCC44","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.39454,-1.16,0.222,14856,0.504,"XYLB, RPEL1, RPE, UGP2, DCXR",0.653647025549361,0.297569463554475,FALSE +"HCC44","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.33773,-0.98,0.481,14924,0.891,"GPI, DERA, RPEL1, PRPS2, PFKL, ALDOA, RPE",0.317854923626168,0.0501222959631252,FALSE +"HCC44","Input","KEGG_PEROXISOME",-0.56653,-1.65,0.0187,14879,0.109,"FAR2, AGPS, ACAA1, IDH2, SLC25A17, ACSL3, GNPAT, PEX1, DECR2, EHHADH, PEX16, NUDT12, CAT, ABCD4, AMACR, PEX14, PAOX, SOD1, HMGCL, PEX6, CROT, FAR1, IDH1, PMVK, MPV17, PHYH, ACOX1, PEX26, ACSL1, PXMP4, PECR, PEX13, PEX19, ACOT8, PEX11A, PEX2, PEX11B, MVK, PRDX5",1.7281583934635,0.962573502059376,TRUE +"HCC44","Input","KEGG_PHENYLALANINE_METABOLISM",-0.30137,-0.869,0.685,18020,1,"GOT1, NAA80",0.164309428507574,0,FALSE +"HCC44","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.40758,-1.19,0.183,12578,0.51,"CDS1, INPP5D, PRKCG, PIK3R3, PLCD4, PIK3C2A, PIK3C3, IMPA2, CALML6, PIP5K1A, PIK3R1, CALM1, PLCB4, PIP4K2C, INPP5K, ITPKA, PLCG2, DGKZ, INPP4B, PIP4K2B, PI4KB, ITPKB, PIK3CA, PI4KA, INPP5E, DGKQ, CALM2, DGKA, PIKFYVE, INPPL1, INPP4A, PIK3C2B, PLCD1, PLCG1, CDS2, PIK3R2, CALM3, CDIPT, PLCB3, INPP5B",0.737548910269571,0.292429823902064,FALSE +"HCC44","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.4969,-1.47,0.0305,13076,0.196,"BLVRB, UROS, HCCS, EARS2, BLVRA, CPOX, ALAS1, HMBS, HMOX2, MMAB, PPOX, ALAD, COX15",1.51570016065321,0.707743928643524,TRUE +"HCC44","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.28413,-0.827,0.761,13748,1,"SCP2, RXRA, ACADM, SORBS1, NR1H3, CPT1C, PDPK1, ACAA1, ACSL3, EHHADH, UBC, SCD5, RXRB, SLC27A4, CPT1B, ILK, ACOX1, SLC27A1, ACSL1, DBI",0.118615343229427,0,FALSE +"HCC44","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.30544,-0.904,0.642,11696,1,"CYP7B1, CYP46A1, CYP27A1, HSD17B4, SCP2, AMACR",0.192464971931147,0,FALSE +"HCC44","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.20933,-0.61,0.977,8705,1,"CD79A, PTPRC, CD3D, LCK, ZAP70, BTK, IGLL1, CD19, CD8A, RFXAP, BLNK, JAK3, CD4, TNFRSF13C, RAG1, DCLRE1C, ADA, RFXANK, RFX5, UNG",0.0101054362812269,0,FALSE +"HCC44","Input","KEGG_PRION_DISEASES",0.24129,0.911,0.517,1251,0.782,"CCL5, IL6, IL1B, IL1A, HSPA5, HSPA1A, EGR1",0.286509456906058,0.106793246940152,FALSE +"HCC44","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.46708,-1.36,0.0792,13899,0.293,"MAD2L2, CDC26, ANAPC10, RPS6KA6, PRKACA, PIK3R1, MAPK14, CPEB1, MAPK10, GNAI3, ADCY6, MAPK1, CDK2, ANAPC5, ANAPC7, MAPK9, RPS6KA1, PIK3CA, ADCY9, CCNB1, KRAS, ANAPC11, FZR1, CDC23, CDC27, CDC25B, MAPK11, PLK1, CCNA2, PRKX, BUB1, CCNB2, MAD2L1, CDK1, MAPK3, PIK3R2, CDC25C, PKMYT1",1.10127481841051,0.533132379645891,FALSE +"HCC44","Input","KEGG_PROPANOATE_METABOLISM",-0.56638,-1.65,0.0125,13553,0.109,"ALDH7A1, ACACB, ACADM, ACAT2, SUCLA2, LDHA, ABAT, HADHA, EHHADH, ALDH9A1, ACSS1, ECHS1, MCEE, ACSS2, SUCLG1, ACAT1, HIBCH",1.90308998699194,0.962573502059376,TRUE +"HCC44","Input","KEGG_PROSTATE_CANCER",-0.3657,-1.09,0.32,12908,0.636,"CASP9, SOS2, BCL2, PDGFRB, CREBBP, PDGFC, AKT1, ATF4, PIK3R1, PDGFD, PDGFB, MAPK1, CDK2, FGFR2, PDPK1, LEF1, GSTP1, PIK3CA, CREB1, GSK3B, MDM2, TCF7L1, CDKN1B, GRB2, KRAS, RELA, E2F1, CREB3L4, IKBKB, E2F2, ERBB2, SOS1, CREB3, HRAS, TP53, MAPK3, PIK3R2, BAD",0.494850021680094,0.196542884351586,FALSE +"HCC44","Input","KEGG_PROTEASOME",-0.4455,-1.31,0.112,11249,0.353,"PSMD7, PSMD2, PSMD3, PSMC5, PSMB7, PSMA5, PSMB1, PSMD6, PSMF1, PSMB10, PSMB2, PSMA1, PSMB5, PSMA2, PSMB4, PSMC2, PSMB3, PSMA4, PSMD1, PSMD4, PSMD13, PSMB6, PSMD14, PSMC3, SEM1",0.950781977329818,0.452225294612177,FALSE +"HCC44","Input","KEGG_PROTEIN_EXPORT",-0.39777,-1.17,0.217,14823,0.494,"SPCS1, SRP68, SEC61A2, SEC11A, SPCS2, SRP9, IMMP1L, SRP14",0.66354026615147,0.306273051076353,FALSE +"HCC44","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.23545,-0.69,0.92,17617,1,"SLC25A10, MDH1",0.0362121726544447,0,FALSE +"HCC44","Input","KEGG_PURINE_METABOLISM",-0.28405,-0.832,0.735,11825,1,"ADCY5, POLR2C, PDE6B, POLR1B, ITPA, NME1, POLR2A, ADCY10, PDE4C, NUDT5, ENTPD2, AK5, PDE1C, ENTPD8, NME5, PDE8B, POLR3B, GUCY1A1, PDE3B, POLR3GL, NT5C, ENTPD4, POLD1, PDE5A, POLA1, POLR2D, POLE, ENTPD6, PRUNE1, GUCY1B1, POLR2H, NT5M, ADCY6, DCK, RRM1, NPR2, POLE4, PRPS2, ADA, GMPR, POLR2I, PDE9A, POLR2E, POLR3K, ADCY9, RRM2, DGUOK, POLR2J, POLD3, AK1, NME6, PKM, GUK1, POLR2F, POLD4, RRM2B, PRIM2, POLR2K, NUDT2, NUDT9, POLR2G, POLR2L, POLA2, PAPSS1, PDE6D",0.133712660915805,0,FALSE +"HCC44","Input","KEGG_PYRIMIDINE_METABOLISM",-0.36115,-1.06,0.354,13319,0.672,"POLR3GL, NT5C, ENTPD4, POLD1, POLA1, POLR2D, POLE, ENTPD6, POLR2H, NT5M, TXNRD2, DCK, RRM1, POLE4, POLR2I, POLR2E, POLR3K, RRM2, POLR2J, POLD3, NME6, POLR2F, POLD4, RRM2B, PRIM2, POLR2K, NUDT2, DUT, CTPS2, POLR2G, UPRT, UCK1, DTYMK, POLR2L, POLA2, TK1",0.450996737974212,0.172630726946175,FALSE +"HCC44","Input","KEGG_PYRUVATE_METABOLISM",-0.45442,-1.33,0.101,13327,0.331,"HAGHL, ALDH7A1, ACACB, DLAT, ACAT2, LDHA, GLO1, GRHPR, ALDH9A1, ACYP2, ACSS1, PKM, PDHB, ACSS2, MDH1, HAGH, PDHA1, ACAT1",0.995678626217357,0.480172006224281,FALSE +"HCC44","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.29494,-0.871,0.713,13205,1,"PDGFRB, RHOA, FGD3, FGF1, MYLPF, PDGFC, RRAS, IQGAP2, CHRM3, ITGA4, IQGAP1, PIP5K1A, ITGAE, ITGB6, ITGA2B, TIAM2, PIK3R1, MYL5, PTK2, FGF13, PDGFD, ARPC4, FGF12, PPP1CC, FGF11, PAK4, CDC42, PDGFB, MAPK1, PIP4K2C, MYH14, VAV3, FGFR2, PAK6, ITGA7, APC, FGFR4, FN1, CRKL, SSH2, PFN1, PIP4K2B, NCKAP1, ITGB8, PIK3CA, WASF2, IQGAP3, BRK1, SSH3, FGD1, PAK1, ARPC5, KRAS, CYFIP2, LIMK2, CYFIP1, ARPC2, PIKFYVE, SOS1, ABI2, GSN, CFL1, GIT1, PPP1CB, HRAS, CSK, MAPK3, PIK3R2, ARPC3, PPP1CA",0.146910470148134,0,FALSE +"HCC44","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.3692,-1.07,0.326,11925,0.66,"ATG5, GABARAPL2, PIK3R4, PIK3C3, GABARAPL1, ATG12, ULK3, BECN1, ATG4C, ATG4D, ATG3, GABARAP, ULK1, ATG4B",0.486782399932061,0.180456064458131,FALSE +"HCC44","Input","KEGG_RENAL_CELL_CARCINOMA",-0.40483,-1.17,0.217,11880,0.494,"MAP2K1, CUL2, AKT2, ARNT2, ARAF, PTPN11, PIK3R3, SOS2, TGFB3, CREBBP, PGF, AKT1, PIK3R1, RAP1A, FLCN, PAK4, CDC42, PDGFB, MAPK1, PAK6, CRKL, FH, PIK3CA, GAB1, RAPGEF1, PAK1, ELOC, GRB2, KRAS, SOS1, EGLN2, ARNT, HRAS, MAPK3, PIK3R2, RBX1, VEGFB, ELOB",0.66354026615147,0.306273051076353,FALSE +"HCC44","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.24293,-0.711,0.902,7767,1,"CPA3, MME, AGTR1, CMA1, CTSG, ACE2, NLN, LNPEP, THOP1, CTSA",0.0447934624580583,0,FALSE +"HCC44","Input","KEGG_RETINOL_METABOLISM",-0.21094,-0.621,0.965,17948,1,"RETSAT, ADH5, DGAT1",0.0154726866562074,0,FALSE +"HCC44","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.26854,-0.787,0.817,8605,1,"ACP5, ENPP1, ENPP3, ACP4, MTMR2, ACP2, ACP1, PHPT1, MTMR6",0.0877779434675845,0,FALSE +"HCC44","Input","KEGG_RIBOSOME",-0.26248,-0.764,0.851,15502,1,"RPL8, RPL37A, RPLP2, RPL41, RPL38, RPS2, RPL30, RPS27L, RPS4X, RPS26, MRPL13, RPLP1, FAU",0.0700704399154121,0,FALSE +"HCC44","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.20584,-0.603,0.966,14164,1,"PIN1, MAPK14, MAPK10, MAP3K1, NLRX1, SIKE1, TBKBP1, MAPK9, TRADD, TANK, FADD, RELA, MAVS, IKBKB, MAPK11, OTUD5, TKFC",0.0150228735845067,0,FALSE +"HCC44","Input","KEGG_RNA_DEGRADATION",-0.52036,-1.51,0.0319,15192,0.19,"PAPOLG, XRN1, LSM8, CNOT7, DCP2, MTREX, LSM6, CNOT9, ZCCHC7, ENO3, EDC3, C1D, EXOSC3, LSM1, CNOT6, DDX6, LSM2, WDR61, EXOSC4, LSM3, CNOT6L, LSM4, EXOSC1, PARN, CNOT8",1.49620931694282,0.721246399047171,TRUE +"HCC44","Input","KEGG_RNA_POLYMERASE",-0.44571,-1.3,0.102,11507,0.358,"POLR3D, POLR2C, POLR1B, POLR2A, POLR3B, POLR3GL, POLR2D, POLR2H, POLR2I, POLR2E, POLR3K, POLR2J, POLR2F, POLR2K, POLR2G, POLR2L",0.991399828238082,0.446116973356126,FALSE +"HCC44","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.37925,-1.11,0.27,17182,0.597,"HEMK1, SEPHS2, MAT2B, PAPSS1, LCMT1",0.568636235841013,0.224025668870631,FALSE +"HCC44","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.22876,0.858,0.654,1952,0.87,"PTGS2, COL4A6, FHIT, TRAF1, ITGA2, LAMC2, MYC, CDKN2B, LAMB3, E2F3, TRAF3, COL4A2, COL4A1, BIRC3, NFKB1, LAMB1, LAMA5, NFKBIA, IKBKG, LAMA3, ITGAV, ITGB1, ITGA3",0.184422251675733,0.0604807473813815,FALSE +"HCC44","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.40795,-1.2,0.167,13791,0.511,"VTI1B, VAMP2, STX12, STX3, STX2, VAMP4, BNIP1, STX18, STX17, STX6, STX5, SNAP47, STX4, STX10, TSNARE1, SNAP29, STX7, SNAP23",0.777283528852417,0.291579099865287,FALSE +"HCC44","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.27985,-0.817,0.799,13121,1,"NEU3, CERK, PLPP1, SMPD3, ACER2, SGPL1, ACER3, GLA, ARSA, SMPD1, GALC, SMPD4, ASAH1, SPHK2",0.0974532206860086,0,FALSE +"HCC44","Input","KEGG_SPLICEOSOME",-0.50857,-1.49,0.0392,13455,0.192,"HNRNPM, SF3A3, SNRNP40, LSM5, LSM7, MAGOH, HSPA1L, PRPF31, PRPF18, U2AF1, DDX23, PHF5A, SMNDC1, AQR, CRNKL1, DHX8, PRPF8, HNRNPK, SNRPB2, PRPF19, HNRNPU, PPIE, SF3B4, SNRPD2, SNRPF, LSM8, SF3B6, SNRNP200, PLRG1, SNRPE, SRSF3, LSM6, SF3A1, RBM17, PRPF38A, SNRPD1, SNRNP27, SF3B1, PRPF40A, WBP11, LSM2, CCDC12, SNRPC, USP39, PPIH, SNRPA, SYF2, SART1, SLU7, SNRPG, SF3B2, LSM3, CWC15, PRPF40B, SRSF9, LSM4, ZMAT2, XAB2, PUF60, PQBP1, PCBP1, CTNNBL1, THOC3, HNRNPA3, SNRPD3",1.40671393297954,0.71669877129645,TRUE +"HCC44","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.21969,-0.644,0.956,8696,1,"PYGB, PYGM, ENPP1, AMY2B, ENPP3, AGL, MGAM, HK3, TREH, UGT2B7, GCK, PGM1, PGM2, HK1, PGM2L1, GPI, UXS1, GAA, GYS1, UGP2, GANC",0.0195421077238999,0,FALSE +"HCC44","Input","KEGG_STEROID_BIOSYNTHESIS",-0.63231,-1.85,0.00419,15389,0.0636,"TM7SF2, EBP, NSDHL, SQLE, LSS, MSMO1, FDFT1, SC5D, HSD17B7",2.3777859770337,1.19654288435159,TRUE +"HCC44","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.19263,0.682,0.901,1142,0.934,"SRD5A2, CYP1B1, HSD11B2, AKR1C3, AKR1C1",0.045275209020937,0.0296531237699066,FALSE +"HCC44","Input","KEGG_SULFUR_METABOLISM",-0.67475,-1.98,0.00106,17252,0.0613,"CHST12, BPNT1, SULT1A3, SUOX, PAPSS1",2.97469413473523,1.21253952548158,TRUE +"HCC44","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.17888,-0.529,0.995,16160,1,"SSB, TRIM21, SNRPD1, SNRPD3",0.00217691925427455,0,FALSE +"HCC44","Input","KEGG_TASTE_TRANSDUCTION",0.33855,1.22,0.204,1532,0.479,"TAS2R46, TAS2R14, TAS2R43, TAS2R9, TAS1R3, TAS2R4, ITPR3, TAS2R13, TAS2R10, TAS2R5",0.690369832574101,0.319664486585437,FALSE +"HCC44","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.35056,1.31,0.125,12415,0.44,"GGT1, GAD1, GAD2, BAAT, GGT5, GGT7, ADO, GGT6, CDO1, CSAD",0.903089986991944,0.356547323513813,FALSE +"HCC44","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.63339,-1.87,0.00106,13801,0.0794,"HMGCR, GGPS1, ACAT2, PDSS2, MVD, HMGCS1, IDI1, PMVK, ACAT1, MVK",2.97469413473523,1.1001794975729,TRUE +"HCC44","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.26954,-0.791,0.815,12104,1,"ACVR1C, DCN, ID1, THBS2, ZFYVE16, SMAD9, CHRD, TGFB3, RBL2, CREBBP, RHOA, ID4, ACVR2A, RBL1, BMP7, ID2, THBS4, BMPR1A, BMP4, PPP2CB, SMAD6, MAPK1, PPP2R1B, ACVR1, SKP1, ZFYVE9, THBS3, ACVR2B, PPP2CA, SMAD5, RPS6KB1, PPP2R1A, BMPR2, RPS6KB2, MAPK3, RBX1, SP1",0.0888423912600234,0,FALSE +"HCC44","Input","KEGG_THYROID_CANCER",-0.42694,-1.25,0.144,13926,0.401,"RXRA, CCDC6, MAPK1, LEF1, NCOA4, TPM3, TCF7L1, RXRB, KRAS, HRAS, TP53, MAPK3",0.84163750790475,0.396855627379818,FALSE +"HCC44","Input","KEGG_TIGHT_JUNCTION",-0.30876,-0.898,0.642,11065,1,"MYL9, NRAS, ACTN2, CLDN9, MAGI2, PRKCI, CRB3, PATJ, GNAI2, MAP3K20, IGSF5, JAM2, PRKCD, AKT2, CSNK2A1, PRKCG, PARD3, CLDN22, EPB41L3, RHOA, PPP2R2B, EPB41, MYLPF, TJP3, RRAS, PRKCQ, CTTN, AKT1, MYH11, CLDN3, JAM3, MYL5, PPP2CB, LLGL1, PARD6G, SPTAN1, GNAI3, PRKCZ, PPP2R2D, CDC42, MYH14, CASK, PPP2R1B, CDK4, MAGI3, LLGL2, TJAP1, PARD6B, PARD6A, PPP2CA, PPP2R2A, CGN, PPP2R1A, KRAS, MPDZ, EPB41L1, SRC, HRAS",0.192464971931147,0,FALSE +"HCC44","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.18443,-0.548,0.99,13969,1,"SPP1, MAP2K7, PIK3R1, MAPK14, MAPK10, MAPK1, TICAM1, IRF5, MAPK9, IFNAR1, TLR3, PIK3CA, STAT1, MAP2K6, IRAK4, FADD, RELA, IKBKB, MAPK11, TOLLIP, MAPK3, PIK3R2, TAB1",0.00436480540245009,0,FALSE +"HCC44","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.30515,-0.894,0.641,14333,1,"OGDH, ACAT2, OGDHL, HADHA, EHHADH, GCDH, CAT, AADAT, ALDH9A1, ECHS1, HADH, ACAT1",0.193141970481183,0,FALSE +"HCC44","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.2847,-0.824,0.766,9549,1,"PIK3R5, PIK3CD, HK3, CACNA1B, PDX1, MAPK8, CACNA1C, MAFA, PIK3CB, CACNA1G, SLC2A4, GCK, MTOR, PRKCD, CACNA1A, PIK3R3, HK1, CACNA1D, INSR, KCNJ11, PIK3R1, MAPK10, PRKCZ, MAPK1, MAPK9, PIK3CA, PKM, IKBKB, MAPK3, PIK3R2",0.115771230367396,0,FALSE +"HCC44","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.59358,2.09,0.0238,1735,0.0997,"TNF, IL2, IL12B, IL1B, IL1A, GAD1, CPE, ICA1",1.62342304294349,1.00130484168834,TRUE +"HCC44","Input","KEGG_TYROSINE_METABOLISM",-0.32666,-0.948,0.548,17182,0.942,"HEMK1, GOT1, NAA80, ADH5, LCMT1",0.261219441515631,0.0259490972071227,FALSE +"HCC44","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.26296,-0.771,0.854,13042,1,"SOS2, CBLC, RHOA, PRKCQ, AKT1, NFATC3, MAP2K7, PIK3R1, MAPK14, CBL, PAK4, CDC42, MAPK1, VAV3, PDPK1, PAK6, NFATC4, CDK4, NFKBIE, PPP3CB, PPP3CC, MAPK9, PIK3CA, GSK3B, PAK1, GRB2, KRAS, RELA, IKBKB, CHP1, SOS1, NCK2, MAPK11, PLCG1, HRAS, MAPK3, PIK3R2",0.068542129310995,0,FALSE +"HCC44","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.49681,-1.46,0.0451,13127,0.202,"ITCH, SKP2, CBLC, UBE2B, ANAPC1, UBE2D3, PRKN, FANCL, TRIP12, UBE2Q2, CDC26, ANAPC10, UBE2D2, UBE2N, UBE2Q1, KLHL9, CBL, FBXW11, PRPF19, WWP1, MAP3K1, UBE2Z, MID1, UBE2K, CDC20, SAE1, ANAPC5, UBE2G1, RNF7, ANAPC7, UBE2D1, SKP1, KLHL13, UBE2F, HUWE1, CUL4B, UBE2W, UBA6, HERC3, MDM2, FBXO4, UBR5, PIAS3, CDC34, UBE4B, ELOC, CUL3, ANAPC11, MGRN1, HERC2, FZR1, RCHY1, CDC23, RHOBTB2, UBA3, BRCA1, UBE3B, PIAS1, PPIL2, CDC27, PML, COP1, UBE2L3, STUB1, UBOX5, UBE2I, DDB1, UBE2R2, UBA1, BTRC, CUL7, UBE2C, HERC1, RBX1, ELOB, DDB2",1.34582345812204,0.694648630553376,TRUE +"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.59423,-1.73,0.00642,17102,0.0998,"PDHB, IARS2, PDHA1",2.19246497193115,1.00086945871263,TRUE +"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.5125,-1.5,0.0298,12913,0.186,"IVD, BCKDHB, ALDH7A1, DBT, ACADM, ACAT2, ACAA1, ABAT, HADHA, EHHADH, HMGCL, ALDH9A1, HMGCS1, AUH, ECHS1, ACADS, MCEE, ACADSB, HADHB, HSD17B10, HADH, ACAT1, HIBCH",1.52578373592374,0.730487055782084,TRUE +"HCC44","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.31717,-0.931,0.574,11672,0.973,"GUCY1A2, ACTG2, PLA2G10, ADCY5, MAP2K1, PRKCD, ARAF, ARHGEF12, PRKG1, PRKCG, GUCY1A1, CACNA1D, RHOA, RAMP2, PRKCQ, CALML6, ADRA1B, MYH11, KCNMA1, KCNMB4, PRKACA, MYL6B, GUCY1B1, CALM1, PLCB4, PPP1CC, GNA11, KCNMB3, ADCY6, MAPK1, NPR2, ACTA2, ARHGEF11, ADCY9, PPP1R12B, MYL6, CALM2, PLA2G4B, PLA2G6, GNAQ, PRKX, PPP1CB, MAPK3, CALM3, PLA2G12A, PPP1CA, PLCB3",0.241088107602027,0.0118871597316481,FALSE +"HCC44","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.55176,-1.61,0.0128,13038,0.128,"DCTN4, DCTN6, RAB5A, VAMP2, DYNLL2, PRKACA, DYNC1I1, ADCY6, ARHGDIB, RAB5C, CREB1, ADCY9, RAB11B, DCTN5, ARHGDIA, STX4, CREB3L4, DYNLL1, DCTN2, DYNC2LI1, PRKX, CREB3, DCTN1, DYNC1I2, RAB5B, RAB11A",1.89279003035213,0.892790030352132,TRUE +"HCC44","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.32871,-0.973,0.502,13572,0.904,"SHC2, AKT1, NFATC3, PIK3R1, MAPK14, PTK2, NOS3, CDC42, MAPK1, NFATC4, PPP3CB, PPP3CC, PLCG2, HSPB1, PIK3CA, KRAS, PLA2G4B, CHP1, PLA2G6, MAPK11, SRC, PLCG1, SPHK2, HRAS, MAPK3, PIK3R2, PLA2G12A, BAD",0.299296282854981,0.0438315695246367,FALSE +"HCC44","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.47245,-1.38,0.0679,14098,0.282,"PRKACA, ATP6V0D1, ARF1, ATP6V0B, ATP6V1G1, ATP6V0A1, ATP6V1G2, ATP6V1B1, ATP6V0E2, PLCG2, ATP6V1A, ATP6V1H, ATP6V0C, ADCY9, SEC61A2, ATP6V1B2, ATP6V1E1, ATP6V0E1, ATP6V1E2, PLCG1, ATP6V1C1, PRKX, ATP6V1F",1.1681302257195,0.549750891680639,FALSE +"HCC44","Input","KEGG_VIRAL_MYOCARDITIS",0.24298,0.915,0.652,2365,0.807,"ITGB2, ICAM1, RAC2, CD55, ABL2, EIF4G1, CD40, EIF4G3, MYH9, CYCS",0.18575240426808,0.0931264652779296,FALSE +"HCC44","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.32111,-0.948,0.548,10108,0.942,"PPP3R2, PPP3CA, DAAM1, WNT11, WNT2B, PRKCA, CAMK2A, LRP5, PPARD, NKD1, MAPK8, ROCK1, PLCB2, PRICKLE2, FZD5, WNT9A, APC2, CSNK1A1, SIAH1, PPP2R5C, LRP6, WNT7A, CXXC4, WNT6, PPP2R5E, FZD8, WNT4, VANGL2, TCF7L2, CCND2, FZD3, CSNK2A1, FRAT2, DAAM2, PRKCG, CAMK2B, WNT10A, RAC3, FZD7, CREBBP, RHOA, SFRP1, AXIN2, WNT10B, NFATC3, CTBP2, PRKACA, MAPK10, PPP2CB, PLCB4, FBXW11, FZD4, CCND3, LEF1, PPP2R1B, TBL1XR1, NFATC4, DVL3, PPP3CB, APC, PPP3CC, FZD2, MAPK9, CAMK2D, SKP1, PPP2R5A, FRAT1, GSK3B, AXIN1, PPP2CA, TCF7L1, PPP2R1A, CAMK2G, DVL2, CACYBP, CHP1, PRKX, CTNNBIP1, BTRC, CTBP1, TP53, PPP2R5B, RBX1, PLCB3, PPP2R5D",0.261219441515631,0.0259490972071227,FALSE +"A549","Input","KEGG_ABC_TRANSPORTERS",0.2741,0.996,0.429,1809,0.627,"ABCG2, ABCC2, ABCC1, ABCC4, ABCC3, ABCD3, ABCB10",0.367542707815276,0.202732459169284,FALSE +"A549","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.36552,-1.31,0.133,16954,0.839,"BRAF, LEF1, PIK3CA, AKT1, RUNX1, PIK3R3, MAPK3, MTOR, PPARD, PML, PIK3R2",0.876148359032914,0.0762380391712997,FALSE +"A549","Input","KEGG_ADHERENS_JUNCTION",0.2964,1.08,0.312,2211,0.56,"PARD3, ACP1, SRC, TGFBR1, TJP1, PTPRJ, IGF1R, ACTG1, ACTN4, PTPRM, VCL, SMAD3, RHOA, SNAI1, SMAD2, NECTIN3, MET, CSNK2A1, FGFR1",0.505845405981557,0.2518119729938,FALSE +"A549","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.20579,0.754,0.815,3746,0.906,"PRKCQ, TRAF2, TNFRSF1A, STAT3, AKT2, CHUK, ACSL3, NFKBIB, ADIPOR2, AKT3, PTPN11, PRKAA2, CAMKK1, CPT1C, ACACB, MAPK9, MAPK8",0.0888423912600234,0.0428718023231869,FALSE +"A549","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.30172,-1.06,0.324,16316,0.637,"GLS2, ABAT, GLUL, GPT, ASS1, IL4I1, ASL, GAD1, GPT2",0.489454989793388,0.19586056766465,FALSE +"A549","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.27822,-0.984,0.426,15843,0.72,"NR3C2, PIK3R1, INSR, PIK3CA, ATP1A1, PIK3R3, MAPK3, PIK3R2",0.370590400897281,0.142667503568732,FALSE +"A549","Input","KEGG_ALLOGRAFT_REJECTION",0.58561,2.12,0.00439,6,0.0847,"IL5",2.35753547975788,1.07211658966929,TRUE +"A549","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.31057,-1.12,0.288,17771,0.7,"PLA2G12A, PLA2G6, PLA2G4B",0.540607512240769,0.154901959985743,FALSE +"A549","Input","KEGG_ALZHEIMERS_DISEASE",0.19008,0.685,0.916,2930,0.921,"GRIN2B, ATP2A2, UQCRFS1, CALM2, TNFRSF1A, PSENEN, COX6B1, IDE, PLCB4, CHP1, NAE1, ATP5F1B, ATP5MC1, PPP3R1, CAPN2, NDUFB10, ADAM17, ATP5F1C, CASP8, GRIN2D, PSEN2, PPP3CA, APAF1, PSEN1, NDUFA9, ADAM10, ATP5MC3, GAPDH, FAS",0.0381045263321496,0.0357403698031511,FALSE +"A549","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.40949,1.48,0.0722,1993,0.318,"EARS2, MTFMT, IARS2, YARS2, FARSB, DARS2, NARS2, SARS2",1.14146280243036,0.497572880015567,FALSE +"A549","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.30292,-1.07,0.332,15267,0.646,"GMPPB, GNPDA1, RENBP, PMM1, GALE, GMPPA, CYB5R1, GALT, UAP1, PGM2, NPL, CYB5R3, GMDS, AMDHD2, HK2",0.478861916295964,0.189767482004916,FALSE +"A549","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.31316,1.14,0.243,3073,0.516,"GRIN2B, TNFRSF1A, TOMM40, CHP1, PPP3R1, MAP2K6, GRIN2D, PPP3CA, APAF1, DERL1, BCL2L1, CYCS",0.614393726401688,0.287350298372789,FALSE +"A549","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.22718,0.849,0.684,1332,0.743,"IFNA13, HSPA2, PSME3, CTSL, HSPA4, HSP90AA1",0.164943898279884,0.129011186239425,FALSE +"A549","Input","KEGG_APOPTOSIS",0.34892,1.28,0.16,3073,0.435,"MAP3K14, TRAF2, TNFRSF1A, AIFM1, CFLAR, IL1R1, AKT2, TNFRSF10D, CHP1, BIRC3, PRKX, PPP3R1, TNFRSF10A, CHUK, TNFRSF10B, CAPN2, IRAK2, CASP8, AKT3, PPP3CA, APAF1, EXOG, FAS, BCL2L1, TNFRSF10C, CYCS",0.795880017344075,0.361510743045363,FALSE +"A549","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.26509,0.956,0.464,885,0.693,"AKR1C3, GPX2, GGT1, CYP4F3, LTA4H, PLA2G4A",0.333482019445119,0.159266765388193,FALSE +"A549","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.29593,1.07,0.351,793,0.561,"P4HA3, AGMAT, ALDH3A2, AMD1, GLS, ALDH1B1, GOT2",0.454692883534176,0.251037138743839,FALSE +"A549","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.36983,1.36,0.128,1975,0.396,"ATP2A2, SGCD, CACNG7, ITGAV, CACNA2D1, CACNG6, ITGB1, ITGA11, GJA1, ACTG1, ACTN4, ITGB5, SGCA, CDH2, CACNG8",0.892790030352132,0.402304814074488,FALSE +"A549","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.63856,2.3,0.0022,739,0.104,"UGDH, ALDH3A2, ALDH1B1",2.65757731917779,0.98296666070122,TRUE +"A549","Input","KEGG_ASTHMA",0.61896,2.28,0.00223,6,0.0807,"IL5",2.65169513695184,1.09312646527793,TRUE +"A549","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.56491,2.03,0.00622,29,0.0981,"IL5, IFNA13",2.20620961530918,1.00833099262005,TRUE +"A549","Input","KEGG_AXON_GUIDANCE",-0.34891,-1.28,0.146,14908,0.812,"RAC3, EPHB1, UNC5A, NFATC1, CXCR4, PLXNC1, NTNG1, SEMA6D, SEMA3F, ABLIM2, EFNB3, SRGAP3, SEMA3D, SEMA6C, EPHB6, EPHA4, EFNA4, PLXNB2, SEMA6A, ARHGEF12, NTN1, EFNA3, SEMA5A, SEMA7A, SLIT2, NCK2, PLXNA2, EFNB1, SEMA3B, UNC5B, LIMK1, SEMA4A, ROBO3, PLXNB3, PAK6, EPHA1, PAK2, PLXNA1, EPHB3, MAPK3, NFATC4, SEMA4C, RAC2, PLXNB1, EFNB2, FYN, SRGAP2, LIMK2, GNAI2, PLXNA3",0.835647144215563,0.0904439707588247,FALSE +"A549","Input","KEGG_BASAL_CELL_CARCINOMA",-0.31089,-1.12,0.273,15378,0.7,"AXIN2, FZD7, AXIN1, DVL2, WNT10A, DVL1, PTCH1, WNT2B, SUFU, STK36, BMP2, LEF1, WNT5A, FZD4, FZD1, GLI3, DVL3",0.563837352959244,0.154901959985743,FALSE +"A549","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.39787,-1.43,0.0967,16587,0.866,"STON1, TAF1, TAF13, GTF2B, TAF4, GTF2H2, TAF11, TAF12, TAF6L, GTF2H4, GTF2IRD1",1.014573525917,0.0624821079826534,FALSE +"A549","Input","KEGG_BASE_EXCISION_REPAIR",0.34063,1.25,0.161,3558,0.45,"NEIL3, TDG, UNG, PCNA, POLE4, LIG3, POLE2, APEX2, POLD4, NEIL2, POLE3, APEX1",0.79317412396815,0.346787486224656,FALSE +"A549","Input","KEGG_BETA_ALANINE_METABOLISM",0.3133,1.14,0.253,3467,0.516,"ALDH3A2, ALDH1B1, HADHA, HIBCH, ALDH2, ECHS1",0.596879478824182,0.287350298372789,FALSE +"A549","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.64676,2.35,0,2949,0.154,"BAAT, ELOVL2, HACD2, HACD1, FADS2, ACOT1, PECR, HADHA, ACOT2, FADS1, YOD1, HSD17B12",Inf,0.812479279163537,TRUE +"A549","Input","KEGG_BLADDER_CANCER",-0.31765,-1.14,0.25,16340,0.722,"RPS6KA5, MMP1, E2F2, BRAF, RASSF1, MAPK3, CDKN2A, VEGFA, VEGFB",0.602059991327962,0.141462802430361,FALSE +"A549","Input","KEGG_BUTANOATE_METABOLISM",0.24206,0.884,0.566,2903,0.713,"AKR1B10, ALDH3A2, ALDH1B1, HADHA, ACSM3, ALDH2, HMGCS1",0.247183568811729,0.146910470148134,FALSE +"A549","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.26891,-0.975,0.438,14885,0.699,"BLNK, RAC3, VAV2, CD72, NFATC1, JUN, CD22, DAPP1, PIK3R1, BCL10, SYK, PIK3CA, AKT1, PIK3R3, MAPK3, IFITM1, NFATC4, RAC2, FOS, PIK3R2",0.3585258894959,0.155522824254319,FALSE +"A549","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2841,1.05,0.367,3051,0.562,"CD38, ATP2A2, CACNA1G, BST1, PHKA1, PLCE1, VDAC1, CALM2, VDAC2, ATP2B1, VDAC3, ADRA1B, GNAL, PLCB4, CHP1, TRPC1, PDE1A, PDE1C, PRKX, PPP3R1, CACNA1H, AGTR1, PLCD3, HRH2, P2RX5, PRKCA, PPID, OXTR, PHKB, GRIN2D, PPP3CA, CAMK2D, HTR2B, SLC25A5, RYR1, ADRA1D",0.435333935747911,0.250263684430939,FALSE +"A549","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.28927,1.06,0.326,1190,0.552,"ATP2A2, UQCRFS1, CACNG7, FXYD2, CACNA2D1, CACNG6, COX6B1, TPM1, TPM2, ATP1B1",0.486782399932061,0.258060922270801,FALSE +"A549","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.2094,0.759,0.808,2687,0.906,"CNTN1, NRCAM, ITGAV, ESAM, ITGAM, CDH4, ITGB1, PVR, PTPRM, CDH2, MPZL1, NEO1, NECTIN3, CLDN1, CLDN2, CADM1, CLDN23, SDC1",0.0925886392254138,0.0428718023231869,FALSE +"A549","Input","KEGG_CELL_CYCLE",0.24874,0.921,0.548,3925,0.686,"YWHAQ, CCND3, ORC4, ORC2, TGFB2, CDC27, ORC5, SMAD3, PCNA, ANAPC5, SMC3, CUL1, MCM6, SMAD2, RBL1, CCNE1, CCNB1, CCNB3, SFN, YWHAG, CDKN1A, CCNB2, SKP1, CDC23, CDC6, PRKDC, CDC26, ORC1, BUB1, PLK1, ANAPC7, SMAD4, STAG2, ANAPC1, CDK1, YWHAB, CDK7, GADD45B, ANAPC11, E2F5, SMC1A, YWHAZ, TTK",0.261219441515631,0.163675884293248,FALSE +"A549","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.18309,-0.661,0.943,14653,0.951,"ADCY4, GNGT1, XCL1, GNB1, VAV2, JAK3, GRK7, BCAR1, CCL5, CXCR4, PRKCD, GNG13, PLCB2, SHC4, PLCB1, SHC3, GNB2, CCL27, GNG7, GNB3, CX3CL1, PIK3R1, RAP1A, PLCB3, SHC2, CCR10, CCL28, BRAF, PIK3CA, AKT1, PRKACA, CRKL, PIK3R3, TIAM2, MAPK3, GRK6, RAC2, GRK4, TIAM1, GRK2, STAT2, GNAI2, FOXO3, PIK3R2",0.0254883072626717,0.0218194830625861,FALSE +"A549","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.33335,-1.2,0.211,15325,0.818,"SHC4, GAB2, SHC3, CBLC, CBL, PIK3R1, HDAC1, SHC2, E2F2, TGFB3, BRAF, PIK3CA, AKT1, CDKN1B, CRKL, RUNX1, PIK3R3, MAPK3, CDKN2A, MECOM, CTBP1, BCR, PIK3R2",0.675717544702307,0.087246696328677,FALSE +"A549","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.54545,-1.96,0.00348,15631,0.362,"CLOCK, CSNK1D, PER1, BHLHE41, CRY2, PER3, NR1D1, CSNK1E",2.45842075605342,0.441291429466834,FALSE +"A549","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29894,1.09,0.296,4429,0.561,"ACLY, IDH3A, DLD, PC, SUCLG1, MDH1, IDH1, IDH3B, SUCLA2, SDHC, ACO1, CS",0.528708288941061,0.251037138743839,FALSE +"A549","Input","KEGG_COLORECTAL_CANCER",-0.26368,-0.947,0.469,14908,0.707,"RAC3, MAPK10, JUN, AXIN2, AXIN1, PIK3R1, BCL2, TGFB3, BRAF, LEF1, PIK3CA, AKT1, PIK3R3, MAPK3, RAC2, RALGDS, FOS, PIK3R2",0.328827157284917,0.150580586203101,FALSE +"A549","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.46565,1.71,0.0252,2571,0.241,"FGA, C5, FGB, FGG, PLG, F2, SERPINE1, PROC, C1S, C4BPA, C4BPB, THBD, F13B, CD59, C5AR1, CFH",1.59859945921846,0.617982957425132,TRUE +"A549","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.30639,1.12,0.283,2736,0.544,"AMD1, GOT2, LDHA, TRDMT1, LDHB, DNMT3B, ADI1, MAT2A, SDS",0.54821356447571,0.26440110030182,FALSE +"A549","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.20573,0.749,0.822,3249,0.887,"IL5, IFNA13, CXCL5, BMPR1B, EDA2R, IL15, TNFRSF1A, TGFBR1, CCL2, CCR7, TGFB2, IL18, CCL26, BMPR1A, IL1R1, TNFRSF10D, IL11, IL13RA1, INHBB, TNFRSF10A, IFNE, CLCF1, TNFRSF10B, PF4, MET, TNFRSF9, FLT4, AMHR2, IL18R1, BMPR2, VEGFD, IL6ST, CSF2RA, TNFSF12, TGFBR2, IFNAR2, TNFSF15, FAS, TNFRSF10C, IL22RA1, TNFSF9, OSMR, EGFR",0.0851281824599496,0.0520763801682736,FALSE +"A549","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.26521,0.954,0.471,2989,0.678,"IFNA13, TBK1, IL18, CHUK, PYCARD, NFKBIB, POLR3K, POLR3G, POLR3F, POLR3D",0.326979092871104,0.168770306132937,FALSE +"A549","Input","KEGG_DILATED_CARDIOMYOPATHY",0.3531,1.28,0.141,1975,0.435,"ATP2A2, SGCD, CACNG7, ITGAV, CACNA2D1, CACNG6, ITGB1, TGFB2, TPM1, ITGA11, TPM2, ACTG1, PRKX, ITGB5, SGCA, TPM4, CACNG8",0.85078088734462,0.361510743045363,FALSE +"A549","Input","KEGG_DNA_REPLICATION",0.43957,1.61,0.051,4206,0.242,"PRIM1, RNASEH1, RFC5, PCNA, RPA1, POLE4, MCM6, POLE2, POLA1, POLD4, DNA2, RNASEH2B, RFC3, SSBP1, POLE3, FEN1, MCM4",1.29242982390206,0.616184634019569,FALSE +"A549","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.30842,-1.1,0.291,15132,0.665,"SPIRE1, NOTCH2, PIWIL4, NOTCH1, ETV7, NOTCH4, MAPK3",0.536107011014093,0.177178354696895,FALSE +"A549","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.12039,0.444,1,1539,1,"ALDH3A1, MGST1, ALDH3B1",0,0,FALSE +"A549","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.27049,0.976,0.454,2345,0.66,"CES1, UMPS, CDA, UCK2, GMPS, CES5A, HPRT1",0.342944147142896,0.180456064458131,FALSE +"A549","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.20132,0.75,0.827,961,0.895,"VTN, COL4A4, ITGAV, COL5A2, SPP1, ITGB1, COL4A6, ITGA11",0.0824944904474534,0.048176964684088,FALSE +"A549","Input","KEGG_ENDOCYTOSIS",-0.20255,-0.729,0.857,14554,0.898,"CSF1R, EPS15, KIT, SH3GL3, EHD4, ARFGAP3, IQSEC1, GRK7, CXCR4, CHMP4B, FGFR3, LDLR, ACAP2, ADRB2, EPN3, ARFGAP1, AGAP2, CBLC, PARD6A, CBL, ASAP3, VPS28, RAB11FIP4, RAB11FIP3, HGS, LDLRAP1, RAB5B, AP2A1, FGFR2, SH3GLB2, AP2M1, VPS4A, RAB22A, PSD, RAB11B, ARAP2, VPS37C, ARAP1, GRK6, SH3GL1, VPS37B, MVB12A, SMAP2, GRK4, ACAP3, GRK2, PIP5K1C, DNM2, ARFGAP2",0.0670191780768018,0.0467236633326956,FALSE +"A549","Input","KEGG_ENDOMETRIAL_CANCER",-0.34472,-1.26,0.174,15378,0.772,"AXIN2, AXIN1, ELK1, PIK3R1, BRAF, LEF1, PIK3CA, AKT1, PIK3R3, MAPK3, FOXO3, PIK3R2",0.7594507517174,0.112382699664264,FALSE +"A549","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.23325,0.859,0.654,3746,0.739,"ATP6V1E2, MAP3K14, MAP2K4, SRC, TJP1, CHUK, ATP6V0E1, MET, ADAM17, PTPN11, LYN, ADAM10, EGFR, ATP6V0E2, ATP6V1C1, MAPK9, MAPK8",0.184422251675733,0.131355561605174,FALSE +"A549","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.26041,-0.931,0.497,14851,0.73,"HBEGF, CAMK2B, MAPK10, JUN, RPS6KB2, SHC4, SHC3, CBLC, ELK1, CBL, PIK3R1, SHC2, BRAF, PIK3CA, AKT1, NCK2, GAB1, CDKN1B, CRKL, PAK6, PAK2, PLCG1, PIK3R3, MAPK3, MTOR, MAP2K7, PIK3R2",0.303643611266668,0.136677139879544,FALSE +"A549","Input","KEGG_ETHER_LIPID_METABOLISM",0.25985,0.935,0.508,3570,0.71,"CHPT1, PLA2G4A, PAFAH1B1, PLPP1, PAFAH1B3, AGPS, PLPP2, LPCAT2",0.294136287716081,0.148741651280925,FALSE +"A549","Input","KEGG_FATTY_ACID_METABOLISM",-0.20678,-0.732,0.848,16436,0.906,"ACADVL, ECI1, ACSL5, HADH, GCDH, CPT2",0.0716041477432862,0.0428718023231869,FALSE +"A549","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.25351,-0.883,0.575,14908,0.773,"RAC3, VAV2, MAPK10, PRKCD, GAB2, MAPK12, PIK3R1, SYK, MAPK14, PIK3CA, AKT1, PLA2G12A, LAT, PLCG1, PIK3R3, PLA2G6, MAPK3, PLA2G4B, RAC2, MAPK13, FYN, MAP2K7, PIK3R2",0.24033215531037,0.111820506081675,FALSE +"A549","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.29224,-1.05,0.353,17036,0.644,"MARCKS, PIK3CA, ARPC5L, AKT1, LIMK1, CRKL, LAT, PLCG1, PIK3R3, WASF3, PLA2G6, MAPK3, PLA2G4B, RAC2, PIP5K1C, LIMK2, DNM2, WASF2, PIK3R2",0.452225294612177,0.191114132640188,FALSE +"A549","Input","KEGG_FOCAL_ADHESION",0.23857,0.877,0.596,4730,0.719,"PDGFD, VTN, ROCK2, FLNB, COL4A4, CCND3, ITGAV, COL5A2, SRC, CRK, SPP1, ITGB1, COL4A6, PPP1CC, VAV1, ARHGAP5, ITGA11, AKT2, BIRC3, IGF1R, ACTG1, ACTN4, ITGB5, VCL, CAV1, RHOA, CAPN2, CAV2, RAP1B, PRKCA, HRAS, MET, COL4A1, FLT4, AKT3, COL5A1, ACTB, VEGFD, PPP1R12A, COL4A2, LAMC2, EGFR, COL11A1, PPP1CB, SOS1, PTK2, MAP2K1, ILK, ACTN1, VAV3, FLNA, MAPK9, MAPK8, PXN, ITGB6, LAMC1, DOCK1, ITGA2B, SOS2, FN1, ROCK1, ITGA5, LAMC3, LAMB1, LAMB4, ZYX, VEGFC, LAMA5, ITGA3, PARVA, MYL2, CTNNB1, ARHGAP35, PIK3CB",0.224753740259764,0.143271109617117,FALSE +"A549","Input","KEGG_FOLATE_BIOSYNTHESIS",0.29043,1.08,0.303,179,0.56,"SPR",0.518557371497695,0.2518119729938,FALSE +"A549","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.29031,1.04,0.359,1301,0.564,"AKR1B10, PFKFB3, AKR1B1, PMM2, PFKP",0.444905551421681,0.248720896016658,FALSE +"A549","Input","KEGG_GALACTOSE_METABOLISM",0.29664,1.07,0.32,1897,0.561,"GLA, AKR1B1, B4GALT1, UGP2, PFKP, MGAM, GALK1",0.494850021680094,0.251037138743839,FALSE +"A549","Input","KEGG_GAP_JUNCTION",0.25132,0.907,0.569,4331,0.69,"PDGFD, TUBA4A, SRC, TJP1, PLCB4, GJA1, PRKX, MAP3K2, TUBAL3, PRKCA, HRAS, TUBA1C, TUBA1B, HTR2B, PRKG2, LPAR1, EGFR, SOS1, CDK1, TUBB4A, MAP2K1, TUBB4B, GNAI1, DRD1, TUBB3, KRAS, SOS2, TUBA1A, ADRB1",0.244887733604929,0.161150909262745,FALSE +"A549","Input","KEGG_GLIOMA",-0.28577,-1.01,0.418,15006,0.721,"CAMK2B, SHC4, SHC3, PDGFRB, CALML6, PIK3R1, SHC2, E2F2, BRAF, PIK3CA, AKT1, PLCG1, PIK3R3, MAPK3, CDKN2A, MTOR, PIK3R2",0.378823718224965,0.142064735280571,FALSE +"A549","Input","KEGG_GLUTATHIONE_METABOLISM",0.4543,1.68,0.0414,2898,0.252,"PGD, G6PD, GPX2, GSR, GCLM, GCLC, GGT1, MGST1, RRM2B, IDH1, RRM1, MGST2, GPX3",1.3829996588791,0.598599459218456,FALSE +"A549","Input","KEGG_GLYCEROLIPID_METABOLISM",0.34439,1.27,0.148,3410,0.44,"GLA, LCLAT1, DGKG, AKR1B1, ALDH3A2, ALDH1B1, DGKD, GPAT3, AGK, PLPP1, ALDH2, GPAT4, MBOAT2, PLPP2, MGLL",0.829738284605043,0.356547323513813,FALSE +"A549","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.2477,0.916,0.555,2061,0.687,"LCLAT1, CDS2, DGKG, CHPT1, CRLS1, PLA2G4A, DGKD, LPGAT1, GPAT3, GPD1L, ETNK1, GNPAT, PTDSS1, PLPP1",0.255707016877324,0.16304326294045,FALSE +"A549","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.25122,-0.907,0.565,15637,0.759,"SARDH, GNMT, DMGDH, CTH, SHMT2, AMT, GCAT",0.247951552180562,0.11975822410452,FALSE +"A549","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.32423,1.17,0.222,2953,0.502,"ALDH3A1, ENO3, GPI, ALDH3A2, ALDH1B1, LDHA, GALM, PFKP, ALDH3B1, DLD, LDHB, TPI1, PKM, ALDH2, PGAM1, GAPDH, ENO1",0.653647025549361,0.299296282854981,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.30104,-1.08,0.292,15581,0.675,"B3GAT3, CHSY3, CHST14, B3GALT6, CHST12, B4GALT7, UST, CHPF",0.534617148551582,0.170696227168975,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.50018,-1.8,0.0142,12935,0.504,"EXTL1, HS6ST3, EXTL2, HS3ST5, NDST3, HS3ST3B1, EXTL3, B3GAT1, EXT1, HS3ST1, XYLT2, B3GAT3, B3GALT6, HS3ST3A1, HS6ST2, HS6ST1, B4GALT7, NDST2",1.84771165561694,0.297569463554475,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.2953,-1.06,0.328,15219,0.637,"CHST6, B4GAT1, CHST2, B4GALT2, B4GALT3, ST3GAL3",0.484126156288321,0.19586056766465,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.47606,-1.69,0.0289,16275,0.614,"HS3ST3A1, SGSH, HYAL2, IDUA, GUSB",1.53910215724345,0.211831628858832,FALSE +"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.34925,-1.24,0.185,13218,0.784,"ST6GALNAC4, ST8SIA5, ST3GAL1, HEXB, SLC33A1, ST6GALNAC6, ST6GALNAC5, B3GALT4",0.732828271596986,0.105683937315562,FALSE +"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.36646,-1.31,0.127,13444,0.839,"FUT9, ST3GAL1, HEXB, B3GALT5, FUT2, FUT1, B3GALNT1, NAGA",0.896196279044043,0.0762380391712997,FALSE +"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.31284,-1.14,0.229,13041,0.722,"FUT7, FUT9, ABO, FUT4, ST3GAL4, B3GALT1, B3GALT5, ST3GAL6, B4GAT1, FUT2, FUT3, FUT1, B4GALT2, B3GNT4, B4GALT3, ST3GAL3",0.640164517660112,0.141462802430361,FALSE +"A549","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.29279,1.06,0.333,4601,0.552,"PIGB, PIGO, PIGF, PIGW, PIGA, PIGN, PIGH, GPLD1, PIGU, PIGC, PIGL, PIGX",0.47755576649368,0.258060922270801,FALSE +"A549","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.30715,1.1,0.29,4623,0.552,"MDH1, MTHFD2, AFMID, MTHFD1, PGP, ACO1, CS, MTHFD2L",0.537602002101044,0.258060922270801,FALSE +"A549","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.27279,-0.968,0.444,14653,0.701,"ADCY4, HBEGF, CACNA1C, CAMK2B, MAPK10, JUN, PRKCD, PLCB2, PLCB1, CALML6, MAPK12, ELK1, GNAS, ITPR3, MAP3K3, PLCB3, MAPK14, LHB, GNA11, PRKACA, MAP3K1, PLA2G12A, ATF4, MAP3K4, PLA2G6, MAPK3, PLA2G4B, MAPK13, MMP14, MAP2K7",0.35261702988538,0.154281982033341,FALSE +"A549","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.2782,-0.991,0.428,8202,0.718,"KIR2DL1, KIR3DL2, IL2, KIR3DL1, KIR2DL3, FASLG, CD80, PRF1, KLRC1, CD86, GZMB, TNF, IL1A, IL6, IL1B",0.368556230986828,0.1438755557577,FALSE +"A549","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.25644,-0.91,0.549,15926,0.765,"CSNK1D, WNT10A, GAS1, BMP7, PTCH1, WNT2B, SUFU, STK36, BMP2, WNT5A, PRKACA, GLI3, CSNK1G2, CSNK1E",0.260427655549908,0.116338564846382,FALSE +"A549","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.25929,0.927,0.499,1152,0.682,"IL5, CD38, ITGAM, IL1R1, IL11",0.30189945437661,0.166215625343521,FALSE +"A549","Input","KEGG_HISTIDINE_METABOLISM",0.4112,1.48,0.071,2752,0.318,"ALDH3A1, AMDHD1, ALDH3A2, ALDH1B1, ALDH3B1, METTL6, METTL2B, BUD23, ALDH2",1.14874165128092,0.497572880015567,FALSE +"A549","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.33074,1.21,0.204,3298,0.474,"RAD50, RAD51C, NBN, RPA1, RAD54B, BLM, POLD4, RAD51D, SSBP1",0.690369832574101,0.324221658325915,FALSE +"A549","Input","KEGG_HUNTINGTONS_DISEASE",-0.2219,-0.799,0.729,14500,0.867,"TBP, NDUFA1, HDAC2, BBC3, GRIN1, NDUFS8, HTT, DNAH2, ATP5PB, PLCB2, DNALI1, PLCB1, NDUFA2, NDUFV3, UQCRB, NDUFA5, CREB3L1, SDHD, COX8A, COX7C, POLR2J, CREB3L2, UQCR10, SP1, EP300, HDAC1, ATP5PO, PLCB3, PPARGC1A, AP2A1, NDUFA3, DNAH1, NDUFA6, AP2M1, POLR2F, NDUFS6, TAF4, CREBBP, CREB3L4, NDUFC1, UQCRHL, CREB5, NDUFB7, ATP5F1D, UQCR11, NDUFA7, ATP5F1E, NDUFS7, DNAL4, NDUFV1, POLR2H, COX5B",0.137272471682025,0.0619809025237897,FALSE +"A549","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.35307,1.29,0.147,1975,0.457,"ATP2A2, SGCD, CACNG7, ITGAV, CACNA2D1, CACNG6, ITGB1, TGFB2, TPM1, ITGA11, TPM2, ACTG1, ITGB5, SGCA, TPM4, CACNG8",0.832682665251824,0.34008379993015,FALSE +"A549","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.32577,-1.19,0.213,15324,0.807,"PLCB2, PLCB1, INPP5J, PLCB3, ITPKB, PIK3CA, INPP5B, ITPKA, PI4KB, SYNJ1, PLCG1, INPPL1, INPP5E, PI4KA, ALDH6A1, PIP5K1C",0.671620396561262,0.0931264652779296,FALSE +"A549","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.26916,-0.979,0.44,15123,0.717,"MAPK10, GYS1, FASN, PYGM, RPS6KB2, SHC4, SHC3, PHKG1, PHKA2, CALML6, CBLC, ELK1, CBL, PIK3R1, MKNK1, PPP1R3D, SHC2, PPARGC1A, INSR, BRAF, PIK3CA, AKT1, FLOT1, TSC1, SORBS1, MKNK2, PRKACA, CRKL, SOCS1, SH2B2, PIK3R3, PTPN1, MAPK3, MTOR, TSC2, PIK3R2, HK2",0.356547323513813,0.1444808443322,FALSE +"A549","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.38221,1.38,0.112,445,0.38,"IL5, MAP3K14, IL15",0.950781977329818,0.42021640338319,FALSE +"A549","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.20203,0.734,0.834,3248,0.887,"IL5, STAT4, IFNA13, CCND3, SOCS5, JAK1, IL15, STAT3, AKT2, IL11, IL13RA1, IFNE, CLCF1, STAT1, AKT3, PTPN11, IL6ST, CSF2RA, PIAS1, IFNAR2, BCL2L1, STAM, SOCS4, STAM2, IL22RA1, OSMR",0.0788339493622613,0.0520763801682736,FALSE +"A549","Input","KEGG_LEISHMANIA_INFECTION",-0.24077,-0.886,0.606,13721,0.779,"TNF, MAPK11, MARCKSL1, TAB2, IL1A, ITGA4, FCGR2A, JUN, IFNGR2, IL1B, MAPK12, ELK1, TLR4, TLR2, MAPK14, ITGB2, TGFB3, MAPK3, MAPK13, TAB1, FOS",0.217527375833714,0.108462542327436,FALSE +"A549","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.20889,-0.742,0.844,14723,0.901,"ITGA4, SIPA1, JAM2, VAV2, BCAR1, CLDN20, CXCR4, CLDN11, CLDN22, CLDN9, CLDN4, RAPGEF4, MAPK12, MYLPF, PIK3R1, RAP1A, RASSF5, TXK, MAPK14, ITGB2, RAPGEF3, PIK3CA, CLDN7, ICAM1, AFDN, PLCG1, PIK3R3, RAC2, MAPK13, MYL5, GNAI2, PIK3R2",0.073657553374345,0.045275209020937,FALSE +"A549","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.56669,2.04,0.00671,3467,0.107,"ALDH3A2, ALDH1B1, HADHA, ALDH2, YOD1, ECHS1",2.17327747983101,0.97061622231479,TRUE +"A549","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.24918,0.893,0.588,885,0.702,"AKR1B10, PLA2G4A",0.230622673923862,0.153662887870195,FALSE +"A549","Input","KEGG_LONG_TERM_DEPRESSION",-0.19783,-0.72,0.856,14941,0.9,"GUCY1B1, PRKG1, PLCB2, PLCB1, GUCY1A1, GNAS, ITPR3, GNAO1, PLCB3, BRAF, GNA11, PLA2G12A, PLA2G6, MAPK3, PLA2G4B, GNAI2",0.0675262353228468,0.0457574905606751,FALSE +"A549","Input","KEGG_LONG_TERM_POTENTIATION",0.31951,1.15,0.269,2778,0.528,"GRIN2B, CALM2, RPS6KA3, RPS6KA6, PPP1CC, PLCB4, CHP1, PRKX, PPP3R1, RAP1B, PRKCA, HRAS, GRIN2D, PPP3CA, CAMK2D, PPP1R12A",0.570247719997592,0.277366077466188,FALSE +"A549","Input","KEGG_LYSINE_DEGRADATION",-0.36247,-1.27,0.158,17133,0.791,"KMT5C, OGDHL, KMT5B, SETDB2, PLOD3, OGDH, SETD1B, HADH, DOT1L, AASS, EHMT2, GCDH",0.801342913045577,0.101823516502323,FALSE +"A549","Input","KEGG_LYSOSOME",-0.3232,-1.16,0.243,16365,0.784,"CD164, AP3B2, MANBA, ACP5, ABCB9, TPP1, LAMP3, PPT1, AP4M1, SORT1, MCOLN1, CTSA, NEU1, SGSH, SMPD1, AP3D1, MAN2B1, ATP6V0B, CTSO, ARSG, LAMP1, ATP6V0C, IGF2R, IDUA, AP1B1, PPT2, GUSB, NAGA, GGA1, GNPTG",0.614393726401688,0.105683937315562,FALSE +"A549","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.1989,0.716,0.849,2968,0.897,"CACNA1G, MAP3K14, FLNB, CACNG7, TRAF2, HSPA2, MAP2K4, RPS6KA3, PPM1B, TNFRSF1A, CACNA2D1, CACNG6, TGFBR1, CRK, MAP3K8, TGFB2, FGF2, RPS6KA6, PLA2G4A, IL1R1, ARRB2, AKT2, CHP1, DUSP1, PRKX, BDNF, PPP3R1, CHUK, MAP3K20, CACNA1H, MAP3K2, MAP2K6, NFKB2, RAP1B, CACNG8, PRKCA, TAOK1, HRAS, FGFR1, FGFR4, DUSP5, AKT3, HSPA8, PPP3CA, NF1, PPM1A, GNG12, HSPA1A, TGFBR2, CACNG4, FAS, RASGRP4, RRAS",0.0710923097560473,0.0472075569559079,FALSE +"A549","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.62782,2.27,0,1038,0.0504,"NR5A2, HNF4A, FOXA2, HNF1A, HNF1B, HHEX",Inf,1.29756946355447,TRUE +"A549","Input","KEGG_MELANOGENESIS",-0.2357,-0.839,0.675,14514,0.819,"WNT6, KIT, ADCY4, CAMK2B, PLCB2, PLCB1, FZD7, CREB3L1, DVL2, CALML6, MC1R, WNT10A, GNAS, CREB3L2, DVL1, EP300, GNAO1, PLCB3, WNT2B, LEF1, WNT5A, FZD4, PRKACA, CREBBP, CREB3L4, FZD1, MAPK3, GNAI2, DVL3",0.170696227168975,0.0867160982395816,FALSE +"A549","Input","KEGG_MELANOMA",-0.23597,-0.847,0.668,15856,0.827,"PDGFRB, FGF22, PDGFC, PIK3R1, FGF12, E2F2, FGF13, BRAF, PIK3CA, AKT1, FGF11, PIK3R3, MAPK3, CDKN2A, PIK3R2",0.175223537524454,0.0824944904474534,FALSE +"A549","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.40668,1.5,0.0635,1756,0.323,"AKR1C2, AKR1C3, ALDH3A1, AKR1C1, MGST1, CYP2S1, ALDH3B1, AKR1C4, EPHX1",1.19722627470802,0.490797477668897,FALSE +"A549","Input","KEGG_MISMATCH_REPAIR",0.62679,2.27,0,3298,0.0504,"MSH6, MLH3, RFC5, PCNA, RPA1, EXO1, MSH2, MSH3, POLD4, MLH1, RFC3, SSBP1",Inf,1.29756946355447,TRUE +"A549","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.35255,-1.28,0.165,15990,0.812,"MLST8, PIK3R1, STK11, BRAF, PIK3CA, AKT1, TSC1, PIK3R3, MAPK3, MTOR, VEGFA, TSC2, RPS6KA2, VEGFB, PIK3R2",0.782516055786094,0.0904439707588247,FALSE +"A549","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.19789,-0.706,0.886,14362,0.909,"KLRK1, ULBP2, ULBP3, RAET1L, RAC3, VAV2, NFATC1, SHC4, SHC3, IFNGR2, ICAM2, PIK3R1, SYK, SHC2, HCST, ITGB2, BRAF, PIK3CA, TNFSF10, ICAM1, IFNAR1, LAT, PLCG1, PIK3R3, MAPK3, NFATC4, RAC2, FYN, SH3BP2, PIK3R2",0.0525662781129492,0.0414361167780325,FALSE +"A549","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.25888,0.928,0.509,427,0.706,"NPY4R, GABRA5, GRIN2B, GLP2R, GABRB3, CHRNA5, HTR1D, PARD3, F2RL2, S1PR3, PLG, P2RY6",0.293282217663241,0.151195298948196,FALSE +"A549","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.29635,-1.07,0.319,15006,0.646,"CAMK2B, MAPK10, RPS6KA1, JUN, PRKCD, SHC4, SHC3, CALML6, MAPK12, NGFR, MAPKAPK2, PIK3R1, RAP1A, RPS6KA5, MAP3K3, ARHGDIB, SHC2, MAPK14, BCL2, CAMK4, SORT1, BRAF, PIK3CA, AKT1, GAB1, CRKL, MAP3K1, ATF4, TP73, PLCG1, SH2B2, PIK3R3, MAPK3, SH2B1, SH2B3, MAPK13, RPS6KA2, MAP2K7, FOXO3, PIK3R2",0.496209316942819,0.189767482004916,FALSE +"A549","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.38506,1.41,0.0941,3284,0.379,"CD38, BST1, NAMPT, NT5C2, NNMT, PNP, AOX1, NT5C",1.02641037657274,0.421360790031928,FALSE +"A549","Input","KEGG_NITROGEN_METABOLISM",0.28161,1.01,0.371,3214,0.606,"CA12, CA8, GLS, GLUD2, CPS1, GLUD1",0.430626090384954,0.217527375833714,FALSE +"A549","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.22647,-0.799,0.737,12898,0.867,"MAP3K7, IKBKB, CXCL8, XIAP, MEFV, TRIP6, TNF, MAPK11, PSTPIP1, TAB2, NOD2, TAB3, NLRP3, MAPK10, CCL5, TNFAIP3, IL6, IL1B, MAPK12, CARD9, NLRP1, NAIP, MAPK14, CASP1, MAPK3, MAPK13, TAB1",0.132532512140949,0.0619809025237897,FALSE +"A549","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.38921,1.41,0.0963,2998,0.379,"RAD50, NHEJ1, XRCC5, XRCC4, PRKDC",1.01637371287547,0.421360790031928,FALSE +"A549","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.40776,-1.45,0.0783,16138,0.918,"PIK3R1, RASSF5, E2F2, BRAF, PIK3CA, RASSF1, AKT1, PLCG1, FHIT, PIK3R3, MAPK3, CDKN2A, FOXO3, RXRB, PIK3R2",1.10623823794206,0.0371573187987575,FALSE +"A549","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.39712,-1.41,0.105,16295,0.83,"DVL1, EP300, HDAC1, DLL1, NOTCH1, DTX3L, RBPJ, MAML2, NOTCH4, CREBBP, HES1, MAML1, RFNG, CTBP1, NCSTN, APH1A, DVL3",0.978810700930062,0.0809219076239261,FALSE +"A549","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.34276,1.23,0.183,3591,0.472,"DDB2, RFC5, PCNA, CETN2, ERCC8, RPA1, POLE4, ERCC1, ERCC4, POLE2, GTF2H1, POLD4, RFC3, MNAT1, ERCC3, CDK7, POLE3, XPC",0.737548910269571,0.326058001365912,FALSE +"A549","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.26796,-0.949,0.474,12011,0.716,"ALG6, DPM1, ST6GAL1, MGAT5, STT3A, RPN2, ALG14, MAN2A2, DPM3, MGAT4B, MAN1A2, MGAT3, ALG3, ALG11, RPN1, GANAB, ALG12, DPM2, MAN1C1, MAN1B1, MGAT2, DDOST, B4GALT2, MOGS, MAN1A1, B4GALT3, MGAT1",0.324221658325915,0.145086977692144,FALSE +"A549","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.21007,-0.763,0.78,6799,0.887,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, CNGA3, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR5AK2, CLCA1, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, OR4C6, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, OR51E2, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, CAMK2A, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR1B1, OR2L3, OR8D1, OR11H6, PDC, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, CNGA4, OR3A2, OR5P2, OR5B21, OR5M11, OR13G1, OR2L13, OR5K1, OR1M1, OR51B2, OR52D1, OR51I1, OR5P3, OR52N2, OR8S1, OR9A2, OR51Q1, OR13D1, OR8D2, OR2T33, OR2S2, OR2A5, OR52H1, CALML3, OR52A1, OR1C1, OR1F1, OR14I1, OR5C1, OR1J4, OR2B11, CALML5, OR2T8, OR2C1, OR8G1, OR4F15, OR52B6, OR51B4, OR2A25, OR2D3, CAMK2G, OR10H1, OR8A1, OR1K1, OR2J3, OR10A6, OR2A2, OR8G5, OR4F3, OR11H4, OR10A4, GUCY2D, OR13A1, OR2A12, OR2D2, OR2H2, OR2AG1, OR10A3, OR2K2, OR7C1, OR10A2, OR7D2, OR2A14, OR13J1, OR4F16, CLCA2, OR2B6, OR4F17, OR2W3, OR2AG2, OR6A2, OR56B4, OR5K2, OR2A42, OR1L8, OR2AE1, OR10AD1, OR2A1, GUCA1B, OR52W1, OR52I1, CAMK2B, PRKG1, CALML6, OR2L2, OR2A7, PRKACA",0.10790539730952,0.0520763801682736,FALSE +"A549","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.32718,1.19,0.207,728,0.487,"MTHFS, ATIC, MTFMT",0.684029654543082,0.312471038785366,FALSE +"A549","Input","KEGG_OOCYTE_MEIOSIS",0.3606,1.32,0.125,3914,0.43,"YWHAQ, CALM2, RPS6KA3, RPS6KA6, PPP1CC, CDC27, CHP1, PPP2CB, IGF1R, SGO1, PRKX, PPP3R1, SLK, ANAPC5, SMC3, CUL1, AURKA, CCNE1, CCNB1, PPP3CA, CAMK2D, YWHAG, CCNB2, SKP1, CDC23, CDC26, BUB1, AR, PLK1, ANAPC7, ANAPC1, PPP2R5E, FBXW11, PPP1CB, CDK1, YWHAB, MAP2K1, ANAPC11, FBXO43, SMC1A, YWHAZ, PPP2R1A",0.903089986991944,0.366531544420413,FALSE +"A549","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.55522,-1.97,0.0108,16382,0.685,"MAN2C1, MANBA, MAN2B2, NEU1, MAN2B1, NEU3",1.96657624451305,0.164309428507574,FALSE +"A549","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.26587,-0.953,0.459,15105,0.72,"ATP6V1B1, ATP5PB, LHPP, NDUFA2, NDUFV3, UQCRB, NDUFA5, ATP6AP1, SDHD, COX8A, COX7C, UQCR10, ATP5PO, ATP6V1G2, NDUFA11, NDUFA3, NDUFA6, ATP5MG, NDUFS6, ATP5ME, NDUFC1, ATP6V0B, UQCRHL, ATP6V0C, NDUFB7, ATP5F1D, UQCR11, NDUFA7, ATP5F1E, NDUFS7, NDUFV1, COX5B",0.338187314462739,0.142667503568732,FALSE +"A549","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.4791,1.78,0.0132,3741,0.194,"GCNT3, GALNT13, GALNT10, GALNT14, GALNT1, GALNT18, GALNT4, C1GALT1C1, GALNT16, GALNT2, GALNT7, C1GALT1",1.87942606879415,0.712198270069774,TRUE +"A549","Input","KEGG_P53_SIGNALING_PATHWAY",0.25453,0.933,0.533,3564,0.705,"TP53I3, CCND3, SERPINE1, DDB2, RRM2B, TNFRSF10B, CASP8, CCNE1, CCNB1, CCNB3, APAF1, SFN, CDKN1A, CCNB2, FAS, CYCS, CDK1, IGFBP3, GADD45B, STEAP3",0.273272790973428,0.151810883008601,FALSE +"A549","Input","KEGG_PANCREATIC_CANCER",-0.27333,-0.975,0.458,16063,0.699,"ARHGEF6, PIK3R1, E2F2, RALA, TGFB3, BRAF, PIK3CA, AKT1, PIK3R3, MAPK3, CDKN2A, VEGFA, RAC2, RALGDS, VEGFB, PIK3R2",0.339134521996131,0.155522824254319,FALSE +"A549","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.17439,-0.618,0.977,11352,0.972,"VNN1, DPYS, ENPP3, UPB1, VNN2, PPCS, PANK4",0.0101054362812269,0.0123337350737254,FALSE +"A549","Input","KEGG_PARKINSONS_DISEASE",-0.23122,-0.843,0.667,15433,0.823,"NDUFA2, NDUFV3, UQCRB, NDUFA5, SDHD, COX8A, COX7C, PRKN, UQCR10, SNCA, ATP5PO, NDUFA3, NDUFA6, UBE2J2, UBE2L6, UBE2G2, NDUFS6, NDUFC1, UQCRHL, NDUFB7, ATP5F1D, UQCR11, NDUFA7, ATP5F1E, UBA7, NDUFS7, NDUFV1, COX5B",0.175874166083451,0.0846001647877302,FALSE +"A549","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.38862,1.4,0.0907,2529,0.38,"YWHAQ, ROCK2, TUBA4A, ARPC3, NCL, ITGB1, KRT18, ACTG1, TUBAL3, RHOA, PRKCA, EZR, CLDN1, ARPC4, TUBA1C, TUBA1B, ACTB",1.0423927129399,0.42021640338319,FALSE +"A549","Input","KEGG_PATHWAYS_IN_CANCER",-0.21416,-0.756,0.789,15302,0.888,"LAMA4, IL6, AXIN2, PIAS4, CCNA1, FGFR3, RXRA, FZD7, AXIN1, DVL2, ARNT, RBX1, PDGFRB, CBLC, FGF22, WNT10A, CBL, PIK3R1, LAMA1, SKP2, RASSF5, DVL1, EP300, HDAC1, MMP1, FGF12, PTCH1, WNT2B, PAX8, TRAF4, E2F2, SUFU, STK36, BMP2, FGF13, BCL2, RALA, ELOB, TGFB3, FGFR2, BRAF, LEF1, PIK3CA, RASSF1, AKT1, CCNE2, WNT5A, FGF11, FZD4, CDKN1B, CRKL, CREBBP, CDKN2B, PIAS3, RUNX1, PLCG1, PIK3R3, FZD1, MAPK3, CDKN2A, GLI3, MTOR, FLT3LG, VEGFA, RAC2, RALGDS, MAX, MECOM, CTBP1, VEGFB, FOS, BCR, PPARD, DVL3, PML, RXRB, PIK3R2",0.10292299679058,0.051587034221399,FALSE +"A549","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.53474,1.91,0.0136,1276,0.132,"UGDH, AKR1B1, RPE, RPEL1, UGP2",1.86646109162978,0.87942606879415,TRUE +"A549","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.45145,1.65,0.0349,1965,0.246,"PGD, G6PD, TKT, GPI, RPE, RPEL1, RBKS, PFKP, PRPS1, TALDO1",1.45717457304082,0.609064892896621,TRUE +"A549","Input","KEGG_PEROXISOME",-0.27864,-0.997,0.413,15908,0.736,"PAOX, PMVK, PEX3, PEX6, PEX11G, PEX1, PXMP2, PEX11B, PEX19, PEX10, PRDX5, ACSL5, IDH2, FAR2, PEX16, PEX26, ABCD4, PEX7, ACOT8, ABCD1, HMGCL, PEX14",0.384049948343599,0.133122185662501,FALSE +"A549","Input","KEGG_PHENYLALANINE_METABOLISM",0.3522,1.26,0.193,1539,0.446,"ALDH3A1, GOT2, ALDH3B1",0.714442690992226,0.350665141287858,FALSE +"A549","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.3203,-1.15,0.243,15324,0.751,"PLCB2, PLCB1, INPP5J, CALML6, CDS1, PIK3R1, ITPR3, PLCB3, ITPKB, PIK3CA, INPP5B, ITPKA, PI4KB, DGKZ, DGKQ, SYNJ1, PLCG1, INPPL1, PIK3R3, INPP5E, PI4KA, PIP5K1C, PIK3R2",0.614393726401688,0.124360062995832,FALSE +"A549","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.33456,1.22,0.187,2727,0.478,"HMOX1, EARS2, COX15, COX10, BLVRB, HCCS, FECH, FTH1, ALAS1",0.728158393463501,0.320572103387881,FALSE +"A549","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.22384,-0.798,0.753,17311,0.856,"ACSL5, SORBS1, PLTP, SLC27A1, PPARA, PPARD, CPT2, RXRB",0.123205023799299,0.0675262353228468,FALSE +"A549","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45993,1.65,0.0432,3031,0.246,"BAAT, AKR1C4, HSD3B7, SLC27A5, ACOX2",1.36451625318509,0.609064892896621,TRUE +"A549","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.33263,-1.18,0.217,12250,0.763,"CD3D, CD19, IL2RG, IGLL1, LCK, RAG1, BLNK, JAK3, DCLRE1C, CIITA, TAP2, IL7R, TNFRSF13C, RFXAP, RFXANK",0.66354026615147,0.11747546204512,FALSE +"A549","Input","KEGG_PRION_DISEASES",-0.29271,-1.07,0.352,15251,0.646,"CCL5, IL6, IL1B, NCAM2, ELK1, NCAM1, NOTCH1, PRKACA, MAPK3, FYN, EGR1",0.453457336521869,0.189767482004916,FALSE +"A549","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.21174,-0.77,0.804,15123,0.886,"MAPK10, RPS6KA1, CCNA1, ANAPC2, MAPK12, PKMYT1, PIK3R1, MAPK14, BRAF, PIK3CA, AKT1, PRKACA, FZR1, PIK3R3, MAD2L2, MAPK3, MAPK13, RPS6KA2, GNAI2, PIK3R2",0.0947439512515487,0.0525662781129492,FALSE +"A549","Input","KEGG_PROPANOATE_METABOLISM",0.35508,1.29,0.155,3700,0.457,"ALDH3A2, ALDH1B1, LDHA, LDHB, SUCLG1, HADHA, ACACA, HIBCH, ALDH2, ACACB, ECHS1, SUCLA2, ACAT1",0.809668301829709,0.34008379993015,FALSE +"A549","Input","KEGG_PROSTATE_CANCER",-0.2988,-1.09,0.309,15622,0.67,"CREB3L1, PDGFRB, PDGFC, PIK3R1, CREB3L2, EP300, E2F2, BCL2, FGFR2, BRAF, LEF1, PIK3CA, AKT1, CCNE2, CDKN1B, CREBBP, ATF4, CREB3L4, PIK3R3, MAPK3, MTOR, CREB5, PIK3R2",0.510041520575165,0.173925197299174,FALSE +"A549","Input","KEGG_PROTEASOME",0.49313,1.8,0.0226,3432,0.195,"PSMA4, PSMC4, PSMB6, PSMD12, PSME3, PSMD8, PSMD1, PSMD11, PSMD14, PSME4, PSMC5, PSMA1, PSMB5, PSMA6, POMP, PSMC6, PSMC1, PSMA3, PSMA2, PSMF1, PSMB3",1.6458915608526,0.709965388637482,TRUE +"A549","Input","KEGG_PROTEIN_EXPORT",0.29925,1.1,0.269,3377,0.552,"SEC11A, OXA1L, SRP68, SEC61A2, SEC62, SEC11C, SRP72",0.570247719997592,0.258060922270801,FALSE +"A549","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.31653,1.14,0.27,3303,0.516,"FXYD2, GLS, ATP1B1, GLUD2, MDH1, GLUD1, ATP1B3",0.568636235841013,0.287350298372789,FALSE +"A549","Input","KEGG_PURINE_METABOLISM",0.36439,1.32,0.129,2835,0.43,"PDE11A, PDE4D, PDE3A, ATIC, PDE10A, PDE8A, NME1, PDE7B, PDE4B, POLR2I, PRIM1, DGUOK, NT5C2, ADA, PDE1A, POLR1E, PDE1C, PRPS1, RRM2B, NME2, PAPSS2, POLE4, POLR2C, GMPS, POLE2, PNP, PKM, NME4, PFAS, HPRT1, POLA1, PNPT1, POLR3K, POLR3G, POLR3F, ADPRM, POLD4, RRM1, PDE6G, PAICS",0.889410289700751,0.366531544420413,FALSE +"A549","Input","KEGG_PYRIMIDINE_METABOLISM",0.38387,1.39,0.101,4771,0.381,"CTPS1, TXNRD1, NME1, UMPS, POLR2I, PRIM1, NT5C2, CDA, POLR1E, RRM2B, NME2, POLE4, POLR2C, UCK2, POLE2, PNP, NME4, POLA1, PNPT1, POLR3K, POLR3G, DTYMK, POLR3F, POLD4, RRM1, CMPK1, POLR3D, NT5C, POLR1B, AK3, POLR2D, UPRT, POLE3, DHODH, TK1, NME7, POLR2L, ITPA, NT5C3A, POLR3H, POLR3C, POLR3B, CTPS2, POLR1D, POLR1A, TXNRD2",0.995678626217357,0.419075024324381,FALSE +"A549","Input","KEGG_PYRUVATE_METABOLISM",0.44128,1.62,0.05,2894,0.259,"AKR1B1, ME1, ALDH3A2, ALDH1B1, LDHA, DLD, LDHB, PC, ME2, MDH1, PKM, ACACA, ALDH2, ME3",1.30102999566398,0.586700235918748,FALSE +"A549","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.19725,0.718,0.889,4136,0.903,"PDGFD, ROCK2, ITGAV, ITGAM, ARPC3, ITGAE, F2, CRK, ITGB1, FGF2, PPP1CC, GNA13, VAV1, ITGA11, NCKAP1, TMSB4Y, ACTG1, ACTN4, CFL2, ITGB5, VCL, RHOA, CFL1, TMSB4X, HRAS, CYFIP2, EZR, FGFR1, FGFR4, ARPC4, ACTB, RDX, ENAH, PFN1, GNG12, PPP1R12A, RRAS, SSH2, MSN, EGFR, CYFIP1, PPP1CB, SOS1, PTK2, RRAS2, MAP2K1, F2R, ACTN1, VAV3, BRK1, APC, PXN, ITGB6, BDKRB2, DOCK1, ITGA2B, KRAS, PFN4, SOS2, FN1",0.0510982390297863,0.0443122496864942,FALSE +"A549","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.33093,1.2,0.221,3285,0.48,"IFNA13, ULK1, ULK2, PRKAA2, ATG7, ATG4C",0.655607726314889,0.318758762624413,FALSE +"A549","Input","KEGG_RENAL_CELL_CARCINOMA",-0.30778,-1.1,0.293,15797,0.665,"ARNT, RBX1, PIK3R1, RAP1A, EP300, ELOB, TGFB3, BRAF, PIK3CA, AKT1, GAB1, CRKL, CREBBP, PAK6, PAK2, PIK3R3, MAPK3, VEGFA, VEGFB, PIK3R2",0.533132379645891,0.177178354696895,FALSE +"A549","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.23516,0.874,0.611,1808,0.717,"NLN, AGTR1",0.213958789757446,0.1444808443322,FALSE +"A549","Input","KEGG_RETINOL_METABOLISM",0.29618,1.1,0.296,3817,0.552,"ALDH1A1, CYP26A1, BCO1, CYP26B1, DHRS3, DHRS4, CYP2C9, DHRS4L2, RDH11, RDH5, PNPLA4",0.528708288941061,0.258060922270801,FALSE +"A549","Input","KEGG_RIBOFLAVIN_METABOLISM",0.43987,1.61,0.0401,409,0.242,"RFK, ACP1",1.39685562737982,0.616184634019569,TRUE +"A549","Input","KEGG_RIBOSOME",-0.31709,-1.11,0.282,16409,0.681,"RPS23, RPL9, RPL38, RPS21, RPL28, RPS25, RPS8, RPL18A, RPS15, RPS10, RPL3, RPL22, RPS18, RPL13, RPS28, RPS12, RPL35A, RPL37, RPL36, FAU",0.549750891680639,0.166852888087215,FALSE +"A549","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.2012,0.735,0.853,2264,0.894,"IFNA13, TBK1, DDX3Y, TRAF2, DDX3X, CHUK, IFNE, NFKBIB, CASP8",0.069050968832477,0.0486624812040823,FALSE +"A549","Input","KEGG_RNA_DEGRADATION",0.27831,1.01,0.396,3655,0.606,"PARN, ENO3, HSPD1, XRN2, EXOSC5, PAPOLA, HSPA9, WDR61, LSM5, PNPT1, CNOT7, C1D, PAPOLG, EXOSC1, ENO1, MPHOSPH6, CNOT9, CNOT1, LSM1, EXOSC3",0.402304814074488,0.217527375833714,FALSE +"A549","Input","KEGG_RNA_POLYMERASE",0.32365,1.18,0.209,4747,0.494,"POLR2I, POLR1E, POLR2C, POLR3K, POLR3G, POLR3F, POLR3D, POLR1B, POLR2D, POLR2L, POLR3H, POLR3C, POLR3B, POLR1D, POLR1A",0.679853713888946,0.306273051076353,FALSE +"A549","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.25081,0.927,0.531,4652,0.682,"GGT1, METTL6, PAPSS2, METTL2B, MAT2A, BUD23, SEPHS1, AHCYL1, AHCY, MARS2, MAT2B",0.274905478918531,0.166215625343521,FALSE +"A549","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.23175,0.85,0.613,3074,0.749,"RARB, COL4A4, ITGAV, TRAF2, ITGB1, COL4A6, AKT2, BIRC3, CHUK, CKS1B, COL4A1, CCNE1, AKT3, APAF1, PTGS2, TRAF3, PIAS1, COL4A2, BCL2L1, CYCS, LAMC2",0.212539525481585,0.125518182300534,FALSE +"A549","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.45204,-1.66,0.0388,16460,0.556,"VAMP4, STX10, STX16, STX12, SEC22B, STX5, VAMP5, TSNARE1, VAMP2, STX3, SNAP29, USE1, SNAP23",1.41116827440579,0.254925208417942,FALSE +"A549","Input","KEGG_SPHINGOLIPID_METABOLISM",0.33046,1.21,0.187,3275,0.474,"GLA, GAL3ST1, SGMS1, DEGS1, ASAH2, GALC, PLPP1, ACER3, SPTLC2, SGPP1, SPTLC1, PLPP2",0.728158393463501,0.324221658325915,FALSE +"A549","Input","KEGG_SPLICEOSOME",-0.30687,-1.12,0.27,17451,0.7,"DHX16, PRPF6, SNU13, TRA2B, LSM4, PRPF38B, SRSF4, CCDC12, PPIH, SYF2, SF3A1, HNRNPA1L2, SNRPD1, LSM7, MAGOH, SNRPD3, LSM6, CWC15, SRSF5, NCBP2, DDX39B, CHERP, XAB2, PRPF38A, SF3A2",0.568636235841013,0.154901959985743,FALSE +"A549","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.25014,0.911,0.54,1700,0.69,"UGDH, PGM2L1, GPI, UGP2, MGAM",0.267606240177031,0.161150909262745,FALSE +"A549","Input","KEGG_STEROID_BIOSYNTHESIS",-0.44337,-1.62,0.0409,15767,0.541,"CEL, SC5D, CYP27B1, TM7SF2, DHCR24, LSS",1.38827669199266,0.266802734893431,FALSE +"A549","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.42547,1.55,0.0601,1711,0.279,"AKR1C2, AKR1C3, SULT2B1, AKR1C1, SRD5A2, HSD17B6, AKR1C4",1.22112552799726,0.554395796726402,FALSE +"A549","Input","KEGG_SULFUR_METABOLISM",0.36038,1.28,0.166,2967,0.435,"SULT2B1, CHST11, PAPSS2, SULT1A4",0.779891911959945,0.361510743045363,FALSE +"A549","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.43534,1.58,0.0342,1426,0.26,"GRIN2B, C5, SNRPB, SSB, C1S, ACTN4",1.46597389394386,0.585026652029182,FALSE +"A549","Input","KEGG_TASTE_TRANSDUCTION",0.24979,0.899,0.55,1430,0.698,"TAS2R50, TAS2R9, PDE1A, ASIC2, TAS2R14, PRKX",0.259637310505756,0.156144577376839,FALSE +"A549","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.53176,1.95,0.00875,374,0.124,"BAAT, GGT1",2.05799194697769,0.906578314837765,TRUE +"A549","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.32003,-1.15,0.242,15900,0.751,"DHDDS, PMVK, FDPS, MVD",0.616184634019569,0.124360062995832,FALSE +"A549","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28987,1.06,0.316,3397,0.552,"BMPR1B, ROCK2, TGFBR1, TGFB2, BMPR1A, BMP6, PPP2CB, INHBB, SMAD3, RHOA, CUL1, SMAD2, RBL1, SMAD6, LTBP1, SMAD7, RPS6KB1, AMHR2, ZFYVE16, BMPR2, SKP1, TGFBR2, ID3, SMAD4, ID2",0.500312917381596,0.258060922270801,FALSE +"A549","Input","KEGG_THYROID_CANCER",-0.30502,-1.11,0.291,16623,0.681,"PAX8, BRAF, LEF1, MAPK3, RXRB",0.536107011014093,0.166852888087215,FALSE +"A549","Input","KEGG_TIGHT_JUNCTION",0.20647,0.741,0.83,2568,0.892,"PRKCQ, PARD3, PPP2R2C, SRC, TJP1, AKT2, PPP2CB, ACTG1, ACTN4, PPP2R2A, MAP3K20, RAB3B, RHOA, PRKCA, HRAS, CSNK2A1, MPDZ, CLDN1, CLDN2, AKT3, ACTB, CLDN23",0.0809219076239261,0.0496351456238769,FALSE +"A549","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.23446,-0.837,0.674,15123,0.81,"MAPK10, JUN, CCL5, IL6, IL1B, TLR5, MAPK12, TLR4, PIK3R1, TLR2, MAPK14, TIRAP, LY96, PIK3CA, AKT1, TLR3, TOLLIP, IFNAR1, PIK3R3, MAPK3, IRF7, MAPK13, TICAM1, TAB1, FOS, MAP2K7, PIK3R2",0.17134010346468,0.0915149811213502,FALSE +"A549","Input","KEGG_TRYPTOPHAN_METABOLISM",0.25942,0.955,0.463,3700,0.685,"KYNU, ALDH3A2, ALDH1B1, IDO2, HADHA, ALDH2, AFMID, AADAT, TDO2, AOX1, ECHS1, ACAT1",0.334419008982047,0.164309428507574,FALSE +"A549","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.3654,-1.31,0.135,12793,0.839,"MAFA, CACNA1B, PDX1, IKBKB, CACNA1A, GCK, TNF, SLC2A4, HK1, CACNA1C, MAPK10, PRKCD, KCNJ11, PIK3R1, INSR, PIK3CA, SOCS1, PIK3R3, MAPK3, MTOR, PIK3R2, HK2",0.869666231504994,0.0762380391712997,FALSE +"A549","Input","KEGG_TYPE_I_DIABETES_MELLITUS",-0.2424,-0.858,0.616,11839,0.816,"PTPRN2, IL12A, CD86, GZMB, TNF, IL1A, IL1B, CPE, ICA1, GAD1",0.210419287835575,0.0883098412461389,FALSE +"A549","Input","KEGG_TYROSINE_METABOLISM",0.27577,1.04,0.368,1856,0.564,"HGD, ALDH3A1, GOT2, ALDH3B1, METTL6, METTL2B",0.434152181326482,0.248720896016658,FALSE +"A549","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.21793,-0.784,0.789,15885,0.873,"CBLC, MAPK12, CBL, PIK3R1, BCL10, MAPK14, PIK3CA, AKT1, NCK2, PAK6, LAT, PAK2, PLCG1, PIK3R3, MAPK3, NFATC4, DLG1, MAPK13, FYN, FOS, MAP2K7, PIK3R2",0.10292299679058,0.0589857562944303,FALSE +"A549","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.26016,0.927,0.491,3348,0.682,"NEDD4, UBA2, CUL3, UBE2G1, HERC4, UBE2A, BIRC6, CDC27, UBE2Q2, UBE2S, DDB2, BIRC3, MID1, BRCA1, ANAPC5, ERCC8, WWP1, CUL1, FANCL, UBE2D1, SAE1, TRIM32, UBE2E1, CUL2, KLHL9, UBE2N, SKP1, CDC23, PIAS1, UBE2D2, CDC26, TRIM37, UBE2M, ANAPC7, ANAPC1, FBXW11, ELOC",0.308918507877032,0.166215625343521,FALSE +"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.33611,-1.2,0.2,18726,0.818,"VARS2",0.698970004336019,0.087246696328677,FALSE +"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.38891,-1.38,0.105,18177,0.839,"PCCB, BCKDHB, ACAD8, HADH, MCCC1, ALDH6A1, IVD, OXCT1, HMGCL",0.978810700930062,0.0762380391712997,FALSE +"A549","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.19282,0.703,0.878,2257,0.907,"PPP1R14A, PRKCQ, ROCK2, CALM2, PPP1CC, ADRA1B, GNA13, PLA2G4A, PLCB4, PRKX, RHOA, AGTR1, PRKCA, CALD1",0.0565054840938974,0.0423927129399047,FALSE +"A549","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.27591,-0.995,0.412,15622,0.724,"CREB3L1, GNAS, CREB3L2, ARHGDIB, RAB5B, DYNC1I1, PRKACA, CREB3L4, RAB11B, VAMP2, CREB5, DYNLL2",0.385102783966865,0.140261433802853,FALSE +"A549","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.33062,-1.18,0.212,15995,0.763,"MAPK12, MAPKAPK2, PIK3R1, SHC2, MAPK14, PIK3CA, AKT1, PLA2G12A, MAPKAPK3, PLCG1, PIK3R3, PLA2G6, MAPK3, NFATC4, PLA2G4B, VEGFA, RAC2, MAPK13, PIK3R2",0.673664139071249,0.11747546204512,FALSE +"A549","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.21946,0.783,0.773,2529,0.869,"ATP6V1E2, TJP1, KDELR1, ACTG1, PRKX, ATP6V0E1, PRKCA, SLC12A2, SEC61A2, ACTB",0.111820506081675,0.0609802235513335,FALSE +"A549","Input","KEGG_VIRAL_MYOCARDITIS",0.20678,0.752,0.794,2529,0.9,"SGCD, EIF4G2, ACTG1, SGCA, CAV1, CASP8, ACTB",0.100179497572904,0.0457574905606751,FALSE +"A549","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.24656,-0.891,0.593,14908,0.781,"RAC3, CAMK2B, MAPK10, NFATC1, CCND2, JUN, PLCB2, PLCB1, DAAM2, AXIN2, CHD8, LRP5, FZD7, AXIN1, DVL2, RBX1, WNT10A, PPP2R5D, DVL1, EP300, PLCB3, SENP2, WNT2B, LEF1, WNT5A, FZD4, PRKACA, PRICKLE1, CREBBP, FRAT2, PORCN, PPP2R5B, FZD1, FRAT1, NFATC4, RAC2, CSNK2B, CTBP1, TBL1XR1, CSNK1E, PPARD, CTNNBIP1, DVL3",0.226945306635737,0.1073489661227,FALSE +"H1703","Input","KEGG_ABC_TRANSPORTERS",-0.3575,-1.33,0.119,14274,0.534,"ABCB11, ABCC2, ABCA8, ABCC9, ABCA6, CFTR, ABCA4, ABCB4, ABCB9, ABCA13, ABCA12, ABCD3, ABCB1, ABCA10, ABCA1, ABCC1, ABCG2, ABCC6, ABCG1, ABCD4, ABCC3, ABCA5, ABCB6",0.924453038607469,0.272458742971444,FALSE +"H1703","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.38364,1.25,0.162,3007,0.599,"EIF4EBP1, STAT3, GRB2, FLT3, MTOR, CHUK, MAPK1, NFKB1, IKBKG, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, RPS6KB1",0.790484985457369,0.222573177610689,FALSE +"H1703","Input","KEGG_ADHERENS_JUNCTION",0.29159,0.93,0.523,3288,0.739,"RAC1, SMAD2, VCL, FGFR1, WASF1, MAP3K7, TGFBR2, EP300, MAPK1, CSNK2B, CTNNA1, SMAD4, AFDN, YES1, IQGAP1, WASF2, NLK, SSX2IP, NECTIN2, RHOA",0.281498311132726,0.131355561605174,FALSE +"H1703","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.39435,1.27,0.148,3697,0.625,"STAT3, ADIPOR2, MAPK9, SOCS3, PRKAG2, PRKAA1, NFKBIE, STK11, MAPK8, MTOR, PTPN11, TNFRSF1A, CHUK, NFKB1, IKBKG, AKT1, PCK2, LEPR, CPT1A, CAMKK2, AKT3, NFKBIB",0.829738284605043,0.204119982655925,FALSE +"H1703","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.25462,0.834,0.704,3341,0.819,"ADSL, CAD, ASNS, GOT1, NIT2, GLUD1, ASL",0.152427340857888,0.0867160982395816,FALSE +"H1703","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.17903,0.578,0.985,3422,1,"SGK1, NEDD4L, MAPK1, KRAS, ATP1A3, PRKCA",0.00656376950238827,0,FALSE +"H1703","Input","KEGG_ALLOGRAFT_REJECTION",0.24222,0.768,0.798,14486,0.89,"CD40, IL12B, IL5, IL12A, IFNG, CD28, CD40LG, IL2, FASLG, CD80, IL4, IL10, PRF1, TNF, FAS, CD86, GZMB",0.0979971086492706,0.0506099933550872,FALSE +"H1703","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.47522,-1.75,0.0196,12060,0.408,"PLA2G2A, PLA2G5, PLA2G2C, PLA2G2F, PLA2G4B, PLA2G4E, PLA2G6, PLA2G3, ACOX1, PLA2G10, FADS2, PLA2G4A",1.70774392864352,0.38933983691012,FALSE +"H1703","Input","KEGG_ALZHEIMERS_DISEASE",0.27885,0.902,0.581,4485,0.774,"GRIN2B, NDUFS6, ITPR2, SDHA, APH1A, NDUFA9, ATP2A1, GAPDH, NDUFA1, ATP5F1A, COX7A2L, IDE, TNFRSF1A, PLCB3, CALML6, PLCB4, MAPK1, NDUFS4, NDUFA3, PPP3R2, CYCS, BID, CYC1, PPP3CB, ATP5F1D, SDHB, NAE1, NDUFS3, ADAM17, CALM3, NDUFA6, NDUFA10, NDUFB8, ATP2A3, ATP5F1C, UQCRHL, UQCRFS1, NDUFC1, PSEN2, BAD, LRP1",0.235823867609669,0.111259039317107,FALSE +"H1703","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.48167,1.56,0.0459,3842,0.434,"YARS2, RARS2, IARS2, HARS2, TARS2, FARSA, AARS2, FARS2",1.33818731446274,0.362510270487489,FALSE +"H1703","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.23372,-0.84,0.629,16354,0.773,"GCK, NPL, GFPT2, RENBP, GFPT1, MPI, GALE, UGDH, HK2, NAGK",0.201349354554731,0.111820506081675,FALSE +"H1703","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.34517,1.1,0.323,2986,0.599,"GRIN2B, MAPK11, NEFH, MAPK12, RAC1, DAXX, TNFRSF1A, PPP3R2, CYCS, BID, PPP3CB, MAPK14",0.490797477668897,0.222573177610689,FALSE +"H1703","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.45574,1.47,0.0709,3014,0.417,"NFYB, HSPA4, KLRC2, KLRC4, HSPA1L, HSP90AB1, TAP2, RFX5, KLRC3, TAP1, PSME3, NFYC, HSPA1A, TAPBP, RFXANK",1.14935376481693,0.379863945026242,FALSE +"H1703","Input","KEGG_APOPTOSIS",0.34432,1.11,0.285,5095,0.616,"MAP3K14, AIFM1, BIRC3, PRKAR2A, BIRC2, TNFRSF1A, DFFA, CHUK, PRKAR2B, NFKB1, IKBKG, AKT1, XIAP, PPP3R2, CYCS, RIPK1, IRAK1, BID, PPP3CB, PRKACA, AKT3, BAX, MYD88, TRAF2, NFKBIA, BAD, ATM, PIK3CB, IRAK2, PRKAR1B, IKBKB, EXOG, TRADD",0.54515513999149,0.210419287835575,FALSE +"H1703","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.44904,-1.6,0.0529,15113,0.41,"PTGIS, GGT6, CYP2J2, GGT5, PLA2G10, CYP4F3, ALOX5, PTGS1, GPX2, PTGS2, LTC4S, GPX3, GPX7, AKR1C3, PLA2G4A, TBXAS1, PTGES, EPHX2, GGT7, CBR3, GPX1",1.27654432796481,0.387216143280265,FALSE +"H1703","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.33675,-1.2,0.188,17949,0.554,"AGMAT, CPS1, CKMT1A, MAOA, CKMT1B, NAGS, ALDH2, ARG2, ASS1, SAT2",0.72584215073632,0.25649023527157,FALSE +"H1703","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.31601,-1.18,0.216,16215,0.572,"DSC2, CACNA1C, ITGA11, TCF7L2, CACNA2D3, CACNG6, RYR2, SLC8A1, CACNA1D, ITGB3, LEF1, ITGA7, ITGB6, DSG2, ITGA1, GJA1, ITGB4, ACTN4, ITGB8, ITGA2",0.665546248849069,0.242603971206976,FALSE +"H1703","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.23666,-0.909,0.617,18008,0.695,"UGDH, ALDH2",0.209714835966758,0.158015195409886,FALSE +"H1703","Input","KEGG_ASTHMA",0.2476,0.815,0.725,14383,0.831,"CD40, IL13, IL5, IL9, MS4A2, EPX, FCER1A, FCER1G, CD40LG, IL3, CCL11, IL4, IL10, TNF, PRG2, RNASE3",0.139661993429006,0.080398976215889,FALSE +"H1703","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.28368,-1.01,0.414,9594,0.633,"IFNA4, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD28, CD40LG, IL2, TPO, FASLG, TSHB, CD80, IFNA13, IL4, CTLA4, IL10, IFNA21, TG, PRF1, TSHR, CGA, FAS, IFNA5, CD86, GZMB",0.382999658879101,0.198596289982645,FALSE +"H1703","Input","KEGG_AXON_GUIDANCE",-0.25682,-0.937,0.531,15670,0.681,"EPHA7, CXCL12, SEMA3G, ABLIM1, EPHB6, ROBO2, EPHA1, EPHA3, PLXNC1, EPHA5, PAK3, EPHA6, FES, SEMA6D, NTNG1, FYN, PLXNB1, SEMA4F, SEMA4A, ABLIM2, RND1, NFATC2, SLIT2, SEMA5A, SEMA7A, EPHB2, EFNB3, PAK6, HRAS, EPHA4, EPHB3, PLXNA2, SEMA3B, RAC2, NFATC4, NRP1, PLXNB3, ABLIM3, NTN4, EFNB2, PLXNA3, RGS3",0.274905478918531,0.166852888087215,FALSE +"H1703","Input","KEGG_BASAL_CELL_CARCINOMA",-0.225,-0.834,0.659,15333,0.772,"HHIP, PTCH1, WNT7B, TP53, WNT7A, SHH, WNT10A, TCF7L2, WNT11, WNT3, LEF1, FZD9, FZD4, FZD8, BMP2, WNT5A, FZD7, BMP4, GLI3, FZD3",0.18111458540599,0.112382699664264,FALSE +"H1703","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.48489,1.54,0.0523,3630,0.441,"TAF9, TBP, GTF2H2, TAF9B, TAF1, TAF5, TAF4B, TAF6, TAF7, TAF2, TAF11, TBPL1, GTF2A1L, TAF5L, TAF1L, GTF2A2",1.28149831113273,0.355561410532161,FALSE +"H1703","Input","KEGG_BASE_EXCISION_REPAIR",0.51093,1.66,0.0228,7134,0.393,"OGG1, POLD2, POLD1, UNG, PARP1, NEIL2, POLL, POLE, LIG1, POLE2, MPG, MBD4, LIG3, NEIL3, NTHL1, PARP4, POLD3, TDG, NEIL1, POLE3, MUTYH, APEX2, FEN1, PARP3, HMGB1, POLB",1.64206515299955,0.405607449624573,FALSE +"H1703","Input","KEGG_BETA_ALANINE_METABOLISM",0.46985,1.51,0.0483,3228,0.412,"AOC2, AOC3, SMS, ALDH3A2, DPYS, HADHA, SRM, ALDH9A1",1.31605286924849,0.385102783966865,FALSE +"H1703","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.2599,-0.946,0.464,16509,0.692,"PECR, FADS2, HSD17B12, ACOT4, TECR, ELOVL6",0.333482019445119,0.159893905543242,FALSE +"H1703","Input","KEGG_BLADDER_CANCER",0.28469,0.934,0.519,2591,0.764,"VEGFD, E2F2, MAPK1, E2F3, E2F1, CDKN2A, KRAS, RAF1, NRAS, MAP2K2",0.284832642151542,0.11690664142431,FALSE +"H1703","Input","KEGG_BUTANOATE_METABOLISM",-0.3172,-1.15,0.247,17676,0.568,"ABAT, ACSM3, ALDH2, BDH2, BDH1, ACADS",0.607303046740334,0.245651664288981,FALSE +"H1703","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.36606,1.18,0.209,2705,0.565,"LILRB3, MALT1, NFATC1, RAC1, NFKBIE, GRB2, CHUK, MAPK1, NFKB1, IKBKG, AKT1, KRAS, PPP3R2, SOS1, RAF1, NRAS, MAP2K2, PPP3CB",0.679853713888946,0.247951552180562,FALSE +"H1703","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.25934,0.842,0.682,2936,0.812,"PDGFRA, TBXA2R, CACNA1A, GNAL, ITPR2, ATP2A1, PHKA1, CACNA1G, ADORA2A, VDAC2, HRH1, PPID, PLCE1, TRHR, PLCB3, CALML6, PLCB4, ADCY3, CACNA1H, VDAC1, SLC25A5, PPP3R2, CACNA1B, PPP3CB, PLCD4, PRKACA, PHKA2",0.166215625343521,0.0904439707588247,FALSE +"H1703","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.17124,0.549,0.985,6539,1,"CACNB1, SLC9A6, COX7A2L, TPM2, TPM3, CYC1, ATP1A3, CACNB4, CACNA2D1, UQCRHL, UQCRFS1, TNNC1, COX7C, UQCRC1, TPM1, UQCR11, COX6C, UQCRB, ATP1B3, UQCRC2, CACNB3, CACNG4, UQCR10, COX7B",0.00656376950238827,0,FALSE +"H1703","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.27553,-1.04,0.365,14211,0.677,"ITGAL, CD86, PECAM1, CDH15, ITGB2, CLDN10, CLDN2, CADM3, NRXN2, CLDN9, CLDN14, CD34, CLDN16, CDH5, NCAM2, VCAM1, SELL, JAM2, NLGN4X, CD6, CNTNAP2, MPZ, CD22, CLDN22, CD4, PDCD1LG2, CNTN1, NLGN1, CLDN11, SDC2, NRXN3, ICAM2, GLG1, NCAM1, CDH1, CLDN3, VCAN, CDH3, NRCAM, CD274, CLDN23, CADM1, NECTIN3, CLDN7, CLDN4, ICAM3, ITGB8, ICAM1, F11R",0.437707135543525,0.169411331314856,FALSE +"H1703","Input","KEGG_CELL_CYCLE",0.47154,1.52,0.0522,6373,0.419,"CCNB3, CCND2, SMAD2, MCM5, CHEK2, MAD2L2, ORC3, YWHAH, E2F2, MCM3, ESPL1, EP300, E2F3, ORC5, E2F1, CDKN2A, CDC25B, CDC45, HDAC2, YWHAE, CDC25A, SMAD4, CDC20, CCNB1, PRKDC, E2F5, SMC1B, CDC27, TTK, PTTG2, ANAPC1, ANAPC7, CCNA2, ANAPC4, CHEK1, FZR1, PKMYT1, RAD21, STAG2, CDC23, CDC6, MCM2, YWHAQ, RB1, TGFB1, PLK1, BUB1B, BUB1, ATM, CREBBP, CCNE2, SMC3, SMAD3, SMC1A, GADD45B, STAG1, CDKN1B, MAD2L1, CDK2, CCND3, TFDP1, MAD1L1, RBX1, YWHAG, MCM6, TFDP2, ATR, E2F4, CDC16, ABL1, MCM7, CDC7, CDK7, CDK1, ORC1, YWHAB, CDKN2C, YWHAZ, CDKN2B, PTTG1",1.28232949699774,0.377785977033705,FALSE +"H1703","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.26517,0.861,0.639,2894,0.821,"RAC1, CCR10, STAT3, SHC1, GRK3, ROCK1, GRK6, GNG13, GRB2, CCL28, CRKL, CCL2, PLCB3, XCL1, CHUK, PLCB4, ADCY3, CSK, MAPK1, CRK, NFKB1, IKBKG, AKT1, KRAS, SOS1, RAF1, CCL5, NRAS, GNB5, GNB2, ARRB2, GNB4, PRKACA",0.1944991418416,0.0856568428805592,FALSE +"H1703","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.37914,1.22,0.19,2591,0.576,"SHC1, GRB2, E2F2, CRKL, CBL, PTPN11, TGFBR2, CHUK, MAPK1, CRK, E2F3, NFKB1, E2F1, IKBKG, CDKN2A, AKT1, KRAS, HDAC2, SOS1, RAF1, CTBP1, NRAS, SMAD4, MAP2K2",0.721246399047171,0.239577516576788,FALSE +"H1703","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.36992,1.2,0.199,3869,0.556,"CLOCK, CRY1, PER3, CSNK1D, PER1, CSNK1E",0.701146923590293,0.254925208417942,FALSE +"H1703","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.33418,1.08,0.311,4539,0.625,"PDHA1, SDHA, ACO2, PCK2, SDHB, OGDH, ACLY, IDH3B, IDH3G, SUCLA2, IDH3A",0.507239610973163,0.204119982655925,FALSE +"H1703","Input","KEGG_COLORECTAL_CANCER",0.4612,1.48,0.0715,5062,0.42,"APC2, RAC1, SMAD2, MAPK9, APC, MAPK8, TGFBR2, MAPK1, MSH6, AKT1, KRAS, MSH2, RAF1, SMAD4, CYCS, MLH1, RHOA, FOS, AKT3, BAX, TGFB1, MSH3, BAD, SMAD3, CTNNB1, PIK3CB, AXIN1, BIRC5, APPL1, AXIN2",1.14569395819892,0.3767507096021,FALSE +"H1703","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.33426,-1.22,0.186,14193,0.564,"C5, MASP1, C4A, SERPIND1, F10, VWF, KLKB1, PROC, A2M, PLAUR, SERPINA5, C4BPB, C1R, CFI, BDKRB1, SERPING1, SERPINA1, THBD, C2, CFB, CD46, C3, BDKRB2, CFH, CD55, PLAU, CD59, PLAT, F3",0.730487055782084,0.248720896016658,FALSE +"H1703","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.26228,0.844,0.674,2883,0.816,"SMS, GOT1, CBS, DNMT1, AHCY, LDHB, SRM, MPST",0.17134010346468,0.0883098412461389,FALSE +"H1703","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.20201,0.656,0.925,1765,0.991,"PDGFRA, VEGFD, FLT4, PDGFC, GHR, PDGFB, CCR10, IL17RA, TNFSF12, LIFR, BMPR1A, OSMR, IL13RA1, CCL28, FLT3, CCL2, TNFRSF1A, TGFBR2, XCL1, IFNAR2, IFNGR2, IL6ST",0.0338582672609674,0.00392634551472468,FALSE +"H1703","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.26593,0.854,0.66,4584,0.803,"POLR3C, POLR3G, CHUK, NFKB1, IKBKG, POLR1C, CCL5, RIPK1, POLR3H, POLR3GL, NFKBIB, POLR3A, POLR3K, NFKBIA, IKBKE, IRF3, IL18",0.180456064458131,0.095284454721319,FALSE +"H1703","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.22761,-0.852,0.688,15983,0.762,"ADCY4, TNNT2, CACNA1C, ITGA11, CACNA2D3, CACNG6, RYR2, SLC8A1, TNNI3, ADCY9, CACNA1D, ITGB3, TGFB3, ADCY7, ITGA7, ITGB6, ITGA1, ITGB4, TGFB2, ITGB8, ITGA2",0.162411561764489,0.1180450286604,FALSE +"H1703","Input","KEGG_DNA_REPLICATION",0.61996,2,0.00376,4068,0.147,"MCM5, RNASEH1, RPA1, POLA1, MCM3, POLD2, DNA2, RFC4, POLD1, PRIM2, RFC2, POLE, RNASEH2B, RFC1, LIG1, RNASEH2A, MCM2, POLE2",2.42481215507234,0.832682665251824,TRUE +"H1703","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.43423,1.41,0.087,5357,0.451,"SPIRE1, ETS1, CPEB1, GRB2, MAPK1, KRAS, SOS1, NOTCH2, SPIRE2, EGFR, NOTCH3, ETV6, FMN2",1.06048074738138,0.345823458122039,FALSE +"H1703","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.25836,-0.971,0.466,14488,0.655,"CYP3A7, ADH1C, CYP2A6, GSTA1, GSTM2, UGT2B7, MAOB, CYP3A5, ALDH3B2, GSTM1, ALDH3A1, ALDH1A3, FMO4, AOX1, GSTT2, ALDH3B1, MAOA, MGST1, MGST2",0.33161408331,0.183758700008217,FALSE +"H1703","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.19701,0.634,0.94,4066,0.992,"DPYS, HPRT1, UCK2, UPP2, IMPDH2, UMPS, GMPS, UPP1, CYP3A43",0.0268721464003014,0.00348832784582135,FALSE +"H1703","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.43845,-1.54,0.078,14804,0.456,"CHAD, COL4A1, VWF, RELN, ITGA10, VTN, THBS2, CD36, COL11A1, THBS4, ITGA11, COL4A4, COL3A1, COL6A3, COL4A6, COL4A2, LAMA1, SDC2, HSPG2, COL1A2, ITGB3, SPP1, ITGA7, ITGB6, COL5A1, ITGA1, LAMA4, SV2A, ITGB4, LAMA3, LAMC2, COL6A1, COL1A1, THBS1, FN1, TNC, ITGB8, ITGA2, LAMB3, LAMB1, CD44",1.10790539730952,0.341035157335565,FALSE +"H1703","Input","KEGG_ENDOCYTOSIS",0.3005,0.952,0.503,4613,0.748,"PDGFRA, VTA1, GIT1, NEDD4, HSPA1L, PLD2, SMAP1, GRK3, PIP4K2B, GRK6, DNM1L, EPN2, NEDD4L, RAB31, PIP5K1A, SMURF2, CBL, RUFY1, SNF8, AP2B1, PDCD6IP, RAB4A, VPS4B, RAB5C, RAB11FIP2, ARRB2, STAM2, HSPA1A, RAB11B, ARFGAP3, RABEP1, IQSEC1, ACAP2, CLTB, AP2A1, ASAP1, SH3KBP1, RAB11FIP3, PARD6A, RBSN, CLTC, PRKCI, VPS36, RAB11A, RET, EPN1, CHMP3, SH3GLB2, CLTCL1, VPS45, PSD, CHMP4A, MVB12B, SH3GLB1, HSPA8, RAB11FIP1, CHMP6, CLTA, EGFR, HGS, FGFR3, HSPA1B",0.298432014944073,0.126098402135539,FALSE +"H1703","Input","KEGG_ENDOMETRIAL_CANCER",0.36401,1.17,0.226,5062,0.565,"APC2, APC, GRB2, MAPK1, AKT1, KRAS, SOS1, RAF1, CTNNA1, NRAS, MAP2K2, PTEN, MLH1, AKT3, BAD, EGFR, CTNNB1, PIK3CB, AXIN1, AXIN2",0.645891560852599,0.247951552180562,FALSE +"H1703","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.37919,1.22,0.174,2474,0.576,"MAPK11, ATP6V1E2, MAPK12, GIT1, RAC1, MAP3K14, MAPK9, MAPK8, ATP6V1C1, PTPN11, CHUK, CSK, HBEGF, NFKB1, IKBKG, CCL5, JAM3",0.7594507517174,0.239577516576788,FALSE +"H1703","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.31112,0.985,0.448,2591,0.699,"NRG2, EIF4EBP1, SHC1, PAK2, MAPK9, GRB2, CRKL, MAPK8, CBL, MTOR, MAPK1, CRK, HBEGF, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2",0.348721986001856,0.155522824254319,FALSE +"H1703","Input","KEGG_ETHER_LIPID_METABOLISM",0.27546,0.892,0.613,2722,0.788,"PLD2, PAFAH1B1, PAFAH1B3, CHPT1, LPCAT1, LPCAT4",0.212539525481585,0.103473782510445,FALSE +"H1703","Input","KEGG_FATTY_ACID_METABOLISM",0.23773,0.77,0.803,3816,0.895,"ALDH3A2, ECI1, HADHA, ADH5, ACAA2, CPT1A, ACADVL, ALDH9A1, ACAT1, HADHB, ACAT2",0.095284454721319,0.048176964684088,FALSE +"H1703","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.3071,0.993,0.442,3676,0.698,"MAPK11, MAPK12, RAC1, MAPK9, GRB2, MAPK8, MAPK1, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, MAPK14, PRKCA, AKT3, MAP2K3",0.354577730650908,0.156144577376839,FALSE +"H1703","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.21447,0.699,0.899,3567,0.963,"RAC1, PLD2, PIP4K2B, DNM1L, PIP5K1A, WASF1, CRKL, MAPK1, CRK, ARPC1B, VASP, AKT1, RAF1, RPS6KB1, WASF2, ASAP1, ARPC5, PRKCA, AKT3",0.0462403082667712,0.0163737128754655,FALSE +"H1703","Input","KEGG_FOCAL_ADHESION",0.25566,0.823,0.719,2361,0.825,"PDGFRA, LAMC3, VEGFD, FLT4, PDGFC, CCND2, PDGFB, RAC1, SHC1, PAK2, MAPK9, COL5A2, MYL12B, VCL, ROCK1, BIRC3, GRB2, CRKL, MAPK8, BIRC2, TLN1, MAPK1, CRK, LAMB2, RAPGEF1, VASP, AKT1, XIAP, SOS1, RAF1, CAV2",0.143271109617117,0.0835460514500749,FALSE +"H1703","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.40759,-1.51,0.0612,15242,0.405,"ALPG, PTS, ALPP, QDPR",1.21324857785444,0.392544976785331,FALSE +"H1703","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.22928,-0.832,0.69,16156,0.762,"FBP1, AKR1B10, PFKFB4, MTMR7, MPI, HK2, ALDOC",0.161150909262745,0.1180450286604,FALSE +"H1703","Input","KEGG_GALACTOSE_METABOLISM",-0.24419,-0.897,0.54,16354,0.706,"GCK, GLB1, B4GALT1, GALE, HK2, GAA",0.267606240177031,0.151195298948196,FALSE +"H1703","Input","KEGG_GAP_JUNCTION",0.32643,1.05,0.367,3882,0.638,"PDGFRA, PDGFC, PDGFB, ITPR2, TUBB3, GRB2, PLCB3, PLCB4, ADCY3, MAPK1, TUBB4A, KRAS, SOS1, RAF1, NRAS, MAP2K2, PRKACA, TUBB6, CSNK1D, PRKCA, TUBB, GNA11, TUBB2B, TUBB2A, GNAI2",0.435333935747911,0.195179321278838,FALSE +"H1703","Input","KEGG_GLIOMA",0.38173,1.23,0.166,3587,0.597,"PDGFRA, PDGFB, SHC1, GRB2, E2F2, MTOR, CALML6, MAPK1, E2F3, E2F1, CDKN2A, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, PTEN, PRKCA, AKT3, CALM3",0.779891911959945,0.224025668870631,FALSE +"H1703","Input","KEGG_GLUTATHIONE_METABOLISM",-0.30408,-1.09,0.313,16922,0.651,"GPX2, ANPEP, GPX3, GPX7, GSTT2, RRM1, GGT7, MGST1, MGST2, GPX1",0.504455662453552,0.186419011431808,FALSE +"H1703","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.27729,-1.02,0.403,18253,0.682,"DGKG, LIPG, GK, ALDH2, DGKA, PLPP3, MGLL",0.39469495385889,0.166215625343521,FALSE +"H1703","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.27262,0.878,0.618,4530,0.802,"PLD2, PEMT, GNPAT, AGPAT1, LPCAT3, LCLAT1, LPGAT1, CHPT1, DGKZ, ETNK1, LPCAT1, LPCAT4, ETNK2, PTDSS1, MBOAT2, DGKH, ACHE, PCYT1A, PGS1, GPAT3, DGKQ, AGPAT4",0.209011524911184,0.0958256317158365,FALSE +"H1703","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.38859,1.24,0.174,4438,0.589,"AOC2, AOC3, CBS, PSAT1, GCAT, PHGDH, PSPH, SRR, AMT, ALAS1",0.7594507517174,0.229884705212898,FALSE +"H1703","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.27207,-1.01,0.393,16071,0.633,"LDHC, ALDH3B2, FBP1, GCK, AKR1A1, ALDH3A1, LDHAL6B, ALDH1A3, LDHA, ALDH3B1, HK2, ACSS1, ALDOC, ALDH2, GALM, ACSS2, ENO2",0.405607449624573,0.198596289982645,FALSE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.28899,0.938,0.523,2370,0.764,"CHST7, CHST13, CSGALNACT2, CHST3, B3GAT1",0.281498311132726,0.11690664142431,FALSE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.36305,-1.32,0.122,14466,0.519,"EXTL1, HS6ST3, HS6ST1, HS3ST5, NDST3, GLCE, EXT1, HS3ST3B1, HS3ST1, B3GALT6, EXTL3, EXTL2, EXT2",0.913640169325252,0.284832642151542,FALSE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.55485,-2.05,0,17207,0.227,"B3GNT7, B4GALT1, CHST6, B4GALT3, ST3GAL1, B4GAT1, B4GALT4",Inf,0.643974142806877,TRUE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.35272,-1.31,0.137,14399,0.506,"HYAL1, GNS, HEXA, GLB1, HGSNAT, HS3ST3B1, HPSE, NAGLU",0.863279432843593,0.295849483160201,FALSE +"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.36302,-1.4,0.107,15441,0.518,"HEXA, SLC33A1, ST6GALNAC3, GLB1, ST8SIA1, ST6GALNAC5, ST3GAL1, ST3GAL5",0.97061622231479,0.285670240254767,FALSE +"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.44206,-1.67,0.0343,16571,0.37,"FUT2, ST8SIA1, B3GALT5, GBGT1, ST3GAL1, FUT1, B3GALNT1",1.46470587995723,0.431798275933005,FALSE +"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.55655,-2.05,0.00939,14036,0.227,"FUT9, B3GALT2, FUT7, ST3GAL6, B3GALT1, ABO, FUT2, FUT3, ST8SIA1, B3GALT5, B4GALT1, B4GALT3, B3GNT3, FUT1, B4GAT1, B4GALT4, B3GNT5",2.02733440773389,0.643974142806877,TRUE +"H1703","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.28154,-1.03,0.404,17741,0.679,"PIGM, PGAP1, PIGP, PIGH",0.393618634889395,0.168130225719498,FALSE +"H1703","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.47917,1.53,0.0417,4607,0.429,"MTHFD1L, ACO2, MTHFD2, PGP, MTHFD1, GRHPR",1.37986394502624,0.367542707815276,FALSE +"H1703","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.34007,1.07,0.354,3676,0.61,"MAPK11, MAPK12, ITPR2, PLD2, MAPK9, GRB2, GNRH2, MAPK8, PLCB3, CALML6, PLCB4, ADCY3, MAPK1, HBEGF, MAP3K4, KRAS, SOS1, RAF1, NRAS, MAP2K2, PRKACA, MAPK14, ATF4, PRKCA, CALM3, GNA11, MAP2K3",0.450996737974212,0.214670164989233,FALSE +"H1703","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.50601,-1.87,0.0104,9878,0.347,"KLRD1, IFNG, KIR2DL1, CD28, KIR3DL2, IL2, KIR3DL1, KIR2DL3, FASLG, CD80, PRF1, TNF, FAS, CD86, GZMB, IL1A, IL6, IL1B",1.98296666070122,0.459670525209126,FALSE +"H1703","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.33871,1.1,0.29,4313,0.599,"GLI1, BTRC, WNT5B, BMP6, RAB23, FBXW11, PTCH2, CSNK1A1, WNT6, PRKACA, BMP7, CSNK1D, CSNK1G3, ZIC2, CSNK1E, STK36, BMP8A, WNT2B",0.537602002101044,0.222573177610689,FALSE +"H1703","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.35053,-1.28,0.147,15494,0.507,"KIT, CSF1R, CD36, FCGR1A, KITLG, CSF2, CD22, CD4, IL1A, IL6, IL1B, IL1R2, ANPEP, CD14, CSF2RA, ITGB3, IL11, ITGA1, IL6R, CD55, CD59, ITGA2, FLT3LG, CD44",0.832682665251824,0.294992040666664,FALSE +"H1703","Input","KEGG_HISTIDINE_METABOLISM",-0.2891,-1.07,0.327,14856,0.672,"ACY3, AOC1, DDC, HEMK1, MAOB, ALDH3B2, ALDH3A1, ALDH1A3, LCMT2, ALDH3B1, MAOA, HNMT, ALDH2",0.485452247339714,0.172630726946175,FALSE +"H1703","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.58066,1.87,0.00745,6162,0.195,"RPA1, RAD52, POLD2, RAD50, POLD1, RAD51, MUS81, MRE11, RAD54L, XRCC3, RAD51D, BRCA2, NBN, XRCC2, RAD54B, BLM, TOP3B, SEM1, EME1, RAD51C, POLD3",2.12784372725171,0.709965388637482,TRUE +"H1703","Input","KEGG_HUNTINGTONS_DISEASE",0.32908,1.05,0.35,4251,0.638,"GRIN2B, NDUFS6, SDHA, NDUFA9, TBP, DLG4, TFAM, NDUFA1, ATP5F1A, VDAC2, TAF4B, COX7A2L, PPID, HIP1, POLR2J, PLCB3, EP300, AP2B1, PLCB4, TBPL1, NDUFS4, VDAC1, NDUFA3, POLR2E, SLC25A5, HDAC2, CYCS, SIN3A, CYC1, ATP5F1D, POLR2H, SDHB, POLR2F, TGM2, CLTB, AP2A1, POLR2B, NDUFS3, POLR2J2, SP1, NDUFA6, BAX, SOD2, NDUFA10, CLTC, NDUFB8, ATP5F1C, UQCRHL, CLTCL1, UQCRFS1, NDUFC1, DCTN1, POLR2A",0.455931955649724,0.195179321278838,FALSE +"H1703","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.24638,-0.873,0.58,16198,0.744,"TNNT2, CACNA1C, ITGA11, CACNA2D3, CACNG6, RYR2, PRKAB1, SLC8A1, TNNI3, IL6, CACNA1D, ITGB3, ACE, TGFB3, ITGA7, ITGB6, ITGA1, ITGB4, TGFB2, ITGB8, ITGA2",0.236572006437063,0.128427064454121,FALSE +"H1703","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.36842,1.19,0.22,4909,0.555,"OCRL, PIP4K2B, IMPA1, PIP5K1A, INPP5B, TPI1, PLCE1, PI4KB, PLCB3, PLCB4, INPP4B, PLCD4, PTEN, PIK3C3, INPP5J, ISYNA1, INPPL1, PLCG2, INPP5E, PIK3CB, IPMK",0.657577319177794,0.255707016877324,FALSE +"H1703","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.34774,1.12,0.293,5499,0.636,"EIF4EBP1, SHC1, MAPK9, SOCS3, PRKAG2, PRKAA1, PHKA1, GRB2, PRKAR2A, CRKL, MAPK8, CBL, MTOR, FLOT1, CALML6, MAPK1, CRK, PRKAR2B, HK3, RAPGEF1, AKT1, KRAS, SOS1, RAF1, NRAS, RHOQ, ACACA, MAP2K2, PCK2, PRKACA, SOCS2, PHKA2, RPS6KB1, FLOT2, MKNK2, TRIP10, AKT3, CALM3, PRKCI, SREBF1, PPP1CC, BAD, EXOC7, FASN, PIK3CB, G6PC2, PRKAR1B, PDE3B, IKBKB, PYGL, RPTOR, TSC2, CALM1, ACACB, SH2B2, PRKAR1A, PRKCZ",0.533132379645891,0.196542884351586,FALSE +"H1703","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.29937,0.951,0.507,2595,0.742,"CCR10, MAP3K14, CCL28, CD40, MADCAM1",0.294992040666664,0.129596094720973,FALSE +"H1703","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.28043,0.883,0.619,2964,0.799,"CCND2, GHR, STAT3, PIAS3, LIFR, SOCS3, OSMR, IL13RA1, GRB2, CBL, PTPN11, EP300, IFNAR2, IFNGR2, IL6ST, SOCS7, PIAS2, LIF, TYK2, AKT1, SOS1, STAM2, SPRY3, SPRY4, IFNW1, SOCS2, LEPR",0.208309350979882,0.0974532206860086,FALSE +"H1703","Input","KEGG_LEISHMANIA_INFECTION",0.29456,0.931,0.552,4257,0.753,"MAPK11, MAPK12, ITGAM, MAP3K7, IFNGR2, MAPK1, NFKB1, TAB1, IRAK1, MAPK14, JAK1, FOS, NFKBIB, TAB2, TGFB1, MYD88, NFKBIA",0.258060922270801,0.123205023799299,FALSE +"H1703","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.19966,0.643,0.941,4070,0.994,"MAPK11, MAPK12, RAC1, ITGAM, MYL12B, VCL, ROCK1, THY1, PTPN11, VASP, OCLN, CTNNA1, JAM3, AFDN, CLDN15, MAPK14, MYL12A, RHOA, PRKCA, PXN, MSN, GNAI2, BCAR1, SIPA1",0.0264103765727431,0.00261361560268669,FALSE +"H1703","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.39056,1.24,0.171,4604,0.589,"ALDH3A2, HADHA, ALDH9A1, ALDH1B1",0.767003889607846,0.229884705212898,FALSE +"H1703","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.27636,-0.999,0.422,11712,0.626,"CYP1A2, PLA2G2A, PLA2G5, PLA2G2C, CYP2E1, PLA2G2F, PLA2G4B, ALOX15, PLA2G4E, PLA2G6, CYP3A7, PLA2G3, CYP2J2, PLA2G10, CYP3A5, AKR1B10, PLA2G4A",0.374687549038326,0.20342566678957,FALSE +"H1703","Input","KEGG_LONG_TERM_DEPRESSION",0.28316,0.908,0.593,2591,0.77,"CACNA1A, ITPR2, PPP2CA, GNA13, PLCB3, PLCB4, MAPK1, GNAZ, KRAS, RAF1, NRAS, MAP2K2",0.226945306635737,0.113509274827518,FALSE +"H1703","Input","KEGG_LONG_TERM_POTENTIATION",0.35671,1.15,0.248,3587,0.6,"GRIN2B, ITPR2, RPS6KA6, PLCB3, EP300, CALML6, PLCB4, MAPK1, KRAS, PPP3R2, RAF1, NRAS, MAP2K2, PPP3CB, PRKACA, ATF4, PRKCA, CALM3",0.605548319173784,0.221848749616356,FALSE +"H1703","Input","KEGG_LYSINE_DEGRADATION",0.3071,0.989,0.434,4958,0.698,"NSD3, ALDH3A2, HADHA, SETD2, NSD2, NSD1, TMLHE, SETDB2, ALDH9A1, OGDH, ACAT1, ACAT2, EHMT2, ALDH1B1, KMT5A, DOT1L",0.362510270487489,0.156144577376839,FALSE +"H1703","Input","KEGG_LYSOSOME",-0.28575,-1.05,0.339,15828,0.697,"ATP6V0B, ATP6V0D1, GBA, SCARB2, ATP6V0A4, ABCB9, SORT1, LAPTM5, ACP5, GLB1, PLA2G15, HGSNAT, SLC11A2, CTSC, CTSB, CTSS, ATP6V1H, NEU1, AP1S3, NAGLU, CTSD, NPC2, CD63, GAA, FUCA1, ENTPD4, AP1M2, TPP1, MANBA, AP3S2, SMPD1, CTSH, ASAH1, CTSZ",0.469800301796918,0.156767221901991,FALSE +"H1703","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.39106,1.26,0.162,3426,0.592,"PDGFRA, MAPK11, CACNA1A, FGF17, MAP3K20, PDGFB, NFKB2, MAPK12, RAC1, MEF2C, MAP3K14, RPS6KA6, MAPK8IP2, PAK2, CACNB1, HSPA1L, MAPK9, RELB, SRF, FGF2, FGF5, CACNA1G, FGFR1, MAP3K12, PPM1B, MAP3K7, DAXX, GRB2, ELK4, HSPB1, CRKL, MAPK8, TNFRSF1A, TGFBR2, FGF12, DUSP16, CHUK, CACNA1H, MAPK1, CRK, RPS6KA4, NFKB1, IKBKG, MAP3K4, CDC25B, TAB1, MAP4K2, AKT1, TAOK1, KRAS, FGF8, PPP3R2, SOS1, RAF1, NRAS, STK3, CACNA1B, ARRB2, MAP2K2, RRAS, HSPA1A, PPP3CB, MRAS, MAPK8IP1, PRKACA, NF1, MAPK14, NLK, MKNK2, ATF4, MAP3K6, FOS, PRKCA, CACNB4",0.790484985457369,0.22767829327708,FALSE +"H1703","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.37293,-1.37,0.128,14279,0.535,"NR5A2, HNF4A, ONECUT1, FOXA3, HNF1B, BHLHA15, GCK, HNF4G, FOXA2, PAX6, HES1",0.892790030352132,0.271646217978772,FALSE +"H1703","Input","KEGG_MELANOGENESIS",-0.20407,-0.756,0.821,15276,0.866,"EDNRB, CAMK2B, CAMK2A, KIT, TYRP1, WNT7B, WNT7A, ADCY4, KITLG, WNT10A, TCF7L2, WNT11, WNT3, ADCY9, CREB3L4, LEF1, ADCY7, FZD9, MITF, FZD4, CREB3L1, FZD8, PLCB2, WNT5A, FZD7, EDN1, HRAS, PLCB1, CREB3L2, FZD3",0.0856568428805592,0.0624821079826534,FALSE +"H1703","Input","KEGG_MELANOMA",0.42035,1.33,0.12,2759,0.541,"PDGFRA, FGF17, PDGFC, PDGFB, FGF2, FGF5, FGFR1, E2F2, FGF12, MAPK1, E2F3, E2F1, CDKN2A, AKT1, KRAS, FGF8, RAF1, NRAS, MAP2K2, PTEN",0.920818753952375,0.266802734893431,FALSE +"H1703","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.31784,-1.17,0.237,14488,0.569,"CYP3A7, ADH1C, GSTA1, DHDH, GSTM2, UGT2B7, CYP3A5, ALDH3B2, AKR1C1, GSTM1, ALDH3A1, ALDH1A3, AKR1C2, CYP1B1, GSTT2, AKR1C3, ALDH3B1, CYP1A1, CYP2S1, MGST1, MGST2",0.625251653989896,0.244887733604929,FALSE +"H1703","Input","KEGG_MISMATCH_REPAIR",0.66301,2.15,0.0025,4127,0.152,"PMS2, RPA1, POLD2, MSH6, RFC4, POLD1, MSH2, RFC2, EXO1, MLH1, RFC1, LIG1, MSH3",2.60205999132796,0.818156412055227,TRUE +"H1703","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.39377,1.26,0.153,3567,0.592,"VEGFD, EIF4EBP1, RPS6KA6, PRKAA1, STK11, ULK2, MTOR, MAPK1, AKT1, ULK1, RPS6KB1, MLST8, RICTOR, AKT3",0.815308569182401,0.22767829327708,FALSE +"H1703","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.28633,0.93,0.547,2705,0.739,"KLRK1, NFATC1, RAC1, KLRC2, SHC1, KLRC3, MICA, GRB2, PTPN11, IFNAR2, IFNGR2, MAPK1, MICB, KRAS, PPP3R2, SOS1, RAF1, NRAS, MAP2K2, BID, PPP3CB",0.262012673666569,0.131355561605174,FALSE +"H1703","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.26553,0.865,0.645,1739,0.821,"GRIN2B, GRIN3B, S1PR1, GABRD, TBXA2R, CHRM4, GHR, C5AR1, AVPR2, P2RY4, GABRQ, S1PR5, GHSR, MC5R, ADORA2A, HRH1, LPAR2, GABRR2, TRHR, TRPV1, PTGER4, CRHR2, GRM6, GABBR1, CHRNA5",0.190440285364732,0.0856568428805592,FALSE +"H1703","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.35215,1.13,0.276,5783,0.624,"MAPK11, MAPK12, RAC1, SHC1, RPS6KA6, MAPK9, NFKBIE, YWHAH, GRB2, CRKL, MAPK8, PTPN11, CALML6, CSK, MAPK1, CRK, RPS6KA4, NFKB1, RAPGEF1, AKT1, KRAS, YWHAE, SOS1, RAF1, NRAS, IRAK1, MAP2K2, MAPK14, RHOA, ATF4, AKT3, CALM3, BAX, NFKBIB, YWHAQ, RIPK2, NFKBIA, PLCG2, BAD, CAMK2G, MAPK7, PIK3CB, IRAK2, IKBKB, ZNF274, YWHAG, CALM1, SH2B2, NTF4, CDC42, KIDINS220, ABL1, BEX3",0.559090917934782,0.204815410317576,FALSE +"H1703","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.23279,-0.854,0.669,14031,0.772,"QPRT, ENPP3, ENPP1, BST1, NMNAT2, AOX1, NMNAT3, NNT",0.174573882232177,0.112382699664264,FALSE +"H1703","Input","KEGG_NITROGEN_METABOLISM",-0.27506,-1.01,0.405,17266,0.633,"CA9, GLS2, CA12, CPS1, CTH",0.392544976785331,0.198596289982645,FALSE +"H1703","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.41774,1.35,0.108,3992,0.517,"NLRC4, MAPK11, MAPK12, MAPK9, HSP90AB1, ERBIN, BIRC3, MAP3K7, MAPK8, CCL2, BIRC2, CHUK, MAPK1, NFKB1, IKBKG, TAB1, XIAP, CCL5, MAPK14, SUGT1, NFKBIB, NAIP, TAB2, RIPK2",0.96657624451305,0.286509456906058,FALSE +"H1703","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.62191,2.02,0.00247,4017,0.192,"XRCC6, RAD50, PRKDC, MRE11, POLL, XRCC4, LIG4",2.60730304674033,0.71669877129645,TRUE +"H1703","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.31299,1.02,0.409,4830,0.671,"GRB2, E2F2, MAPK1, E2F3, E2F1, CDKN2A, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, PRKCA, AKT3, RB1, PLCG2, BAD, EGFR, PIK3CB",0.388276691992658,0.173277479831008,FALSE +"H1703","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.31269,1.01,0.44,4661,0.676,"APH1A, NUMBL, EP300, KAT2A, HDAC2, CTBP1, KAT2B, NOTCH2, DVL1, DVL2, MAML1, JAG2, ADAM17, NCOR2, CTBP2, DLL3, PSEN2, DVL3, CREBBP, NOTCH3, MFNG",0.356547323513813,0.170053304058364,FALSE +"H1703","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.43379,1.39,0.0898,6239,0.451,"GTF2H5, RPA1, GTF2H2, CUL4A, POLD2, RFC4, POLD1, RFC2, POLE, CUL4B, RFC1, LIG1, POLE2, ERCC2, ERCC8, CETN2, RBX1, RAD23A, CDK7, POLD3, ERCC1",1.0467236633327,0.345823458122039,FALSE +"H1703","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.26286,-0.93,0.52,17042,0.682,"ALG9, RPN2, B4GALT1, B4GALT3, MAN1C1, ALG10B, MAN1B1, MOGS, MAN1A1, DOLPP1",0.283996656365201,0.166215625343521,FALSE +"H1703","Input","KEGG_OLFACTORY_TRANSDUCTION",0.23183,0.756,0.809,700,0.901,"OR4A47, OR2V2, OR4S1, GNAL, OR2H2, OR2A5, GRK3, OR4F16",0.0920514783877277,0.045275209020937,FALSE +"H1703","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.53985,1.71,0.0183,2373,0.345,"FTCD, MTHFD1L, ATIC, TYMS, GART, MTHFD2",1.73754891026957,0.462180904926726,FALSE +"H1703","Input","KEGG_OOCYTE_MEIOSIS",0.4335,1.4,0.0955,4685,0.45,"PPP2R5A, MAPK12, ITPR2, BTRC, RPS6KA6, PPP2CA, CPEB1, MAD2L2, YWHAH, ESPL1, FBXW11, FBXO43, CALML6, PPP2R5D, ADCY3, MAPK1, SLK, SGO1, PPP3R2, YWHAE, CDC20, CCNB1, PPP3CB, PRKACA, SMC1B, CDC27, PTTG2, PPP2R5E, ANAPC1, ANAPC7, ANAPC4, PKMYT1, CDC23, CALM3, YWHAQ, FBXO5, PLK1, PPP1CC, BUB1, CCNE2, SMC3, CAMK2G, SMC1A",1.01999662841625,0.346787486224656,FALSE +"H1703","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.4118,-1.51,0.0952,15441,0.405,"HEXA, GBA, GLB1, NEU1, FUCA1, MANBA",1.02136305161553,0.392544976785331,FALSE +"H1703","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.21251,0.685,0.896,4989,0.97,"ATP6V1E2, NDUFS6, SDHA, NDUFA9, NDUFA1, ATP5F1A, COX7A2L, ATP6V1C1, NDUFS4, COX15, NDUFA3, CYC1, COX10, ATP5F1D, SDHB, COX11, NDUFS3, NDUFA6, NDUFA10, NDUFB8, ATP5F1C, UQCRHL, UQCRFS1, NDUFC1, TCIRG1, ATP6V0A1, COX7C, ATP5PD, UQCRC1",0.0476919903378748,0.0132282657337552,FALSE +"H1703","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.33721,1.07,0.328,301,0.61,"GALNT8, GALNT13",0.484126156288321,0.214670164989233,FALSE +"H1703","Input","KEGG_P53_SIGNALING_PATHWAY",0.34936,1.11,0.282,5416,0.616,"CCNB3, ADGRB1, CCND2, CHEK2, SHISA5, TP53I3, EI24, CDKN2A, SERPINE1, CYCS, GTSE1, CCNB1, BID, PTEN, SESN2, RRM2, COP1, CHEK1, RRM2B, BAX, SIAH1, IGFBP3, ATM, CCNE2, STEAP3, GADD45B, CDK2, CCND3, TSC2, ATR",0.549750891680639,0.210419287835575,FALSE +"H1703","Input","KEGG_PANCREATIC_CANCER",0.4332,1.41,0.0831,2400,0.451,"VEGFD, RAC1, SMAD2, STAT3, MAPK9, RALBP1, E2F2, MAPK8, TGFBR2, CHUK, MAPK1, E2F3, NFKB1, E2F1, RAD51, IKBKG, CDKN2A, AKT1, KRAS, RAF1, SMAD4",1.08039897621589,0.345823458122039,FALSE +"H1703","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.18878,-0.689,0.878,14406,0.922,"ENPP3, VNN1, ENPP1, VNN2, DPYD, BCAT1",0.0565054840938974,0.0352690789463706,FALSE +"H1703","Input","KEGG_PARKINSONS_DISEASE",0.2881,0.925,0.553,5778,0.742,"NDUFS6, UBE2G1, SDHA, NDUFA9, NDUFA1, ATP5F1A, VDAC2, COX7A2L, PPID, UBE2J1, UCHL1, NDUFS4, VDAC1, NDUFA3, SLC25A5, CYCS, CYC1, ATP5F1D, SDHB, NDUFS3, NDUFA6, NDUFA10, NDUFB8, ATP5F1C, UBE2J2, UBE2L3, UQCRHL, UQCRFS1, NDUFC1, UBE2G2, COX7C, ATP5PD, UQCRC1, UBB, UQCR11, NDUFV3, COX6C, VDAC3, UQCRB, ATP5MC1, NDUFAB1",0.257274868695302,0.129596094720973,FALSE +"H1703","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.25677,0.824,0.723,6351,0.831,"ROCK1, TUBB3, ARPC1B, TUBB4A, OCLN, NCL, TUBB6, RHOA, ARPC5, PRKCA, TUBB, TUBB2B, YWHAQ, TUBB2A, ARPC1A, CTNNB1, ROCK2, ACTB, CDC42, CLDN1, ABL1, TUBA1A, ITGB1, ARPC5L, YWHAZ",0.140861702705469,0.080398976215889,FALSE +"H1703","Input","KEGG_PATHWAYS_IN_CANCER",0.29938,0.954,0.509,4615,0.753,"PDGFRA, LAMC3, FGF17, VEGFD, APC2, GLI1, PDGFB, NFKB2, RAC1, SMAD2, STAT3, WNT5B, PIAS3, ARNT, MAPK9, HSP90AB1, ETS1, RALBP1, FGF2, FGF5, FGFR1, BIRC3, TRAF3, APC, GRB2, FLT3, E2F2, CRKL, MAPK8, CBL, MTOR, EGLN1, BIRC2, PTCH2, TGFBR2, EP300, FGF12, VHL, CHUK, MAPK1, CRK, MSH6, E2F3, NFKB1, CCDC6, LAMB2, E2F1, RAD51, IKBKG, PIAS2, CDKN2A, TPM3, AKT1, XIAP, KRAS, FGF8, HDAC2, SOS1, MSH2, RAF1, CTNNA1, CTBP1, NRAS, SMAD4, CYCS, MAP2K2, BID, DVL1, PTEN, DVL2, WNT6, MLH1, RHOA, BRCA2, JAK1, FOS, PRKCA, AKT3, BAX, TRAF1, TRAF5, RB1, LAMA5, TGFB1, CTBP2, RET, STK36, MSH3, DAPK3, TRAF2, NFKBIA, WNT2B, DVL3, PLCG2, ELOC, BAD, CUL2, CREBBP, CCNE2, EGFR, SMAD3, CTNNB1, FGFR3, EGLN2",0.293282217663241,0.123205023799299,FALSE +"H1703","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.19084,-0.688,0.9,11600,0.908,"UGT2B4, UGT2B17, UGT2A3, UGT2A1, UGT2B15, UGP2, DHDH, UGT2B7, DCXR, UGDH",0.0457574905606751,0.0419141514789149,FALSE +"H1703","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.27662,-1.04,0.386,17989,0.677,"H6PD, ALDOC, TALDO1",0.413412695328245,0.169411331314856,FALSE +"H1703","Input","KEGG_PEROXISOME",0.21494,0.7,0.873,4109,0.97,"PEX5, PEX16, HACL1, SLC25A17, DECR2, GNPAT, PEX26, AMACR, MPV17, PHYH, PEX6, PEX3, PXMP2, ABCD2, SOD2, PXMP4, AGPS, CRAT",0.0589857562944303,0.0132282657337552,FALSE +"H1703","Input","KEGG_PHENYLALANINE_METABOLISM",0.37676,1.2,0.197,1522,0.556,"AOC2, AOC3, GOT1",0.705533773838407,0.254925208417942,FALSE +"H1703","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.34267,1.11,0.304,4486,0.616,"OCRL, ITPR2, PIP4K2B, IMPA1, PIP5K1A, INPP5B, PLCE1, PI4KB, PLCB3, CALML6, PLCB4, DGKZ, INPP4B, PLCD4, PTEN, PIK3C3, INPP5J, PRKCA, CALM3, INPPL1, DGKH, PLCG2, INPP5E, DGKQ",0.517126416391246,0.210419287835575,FALSE +"H1703","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.3162,1.03,0.383,3089,0.657,"HMOX1, FECH, COX15, COX10, FTH1",0.416801226031377,0.182434630440219,FALSE +"H1703","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.3797,-1.35,0.126,13054,0.535,"CYP8B1, CYP7A1, PCK1, APOA1, CPT1B, FABP1, ACSL1, HMGCS2, RXRG, ACSL6, FABP4, CYP4A22, DBI, APOA2, SLC27A6, ACSL3, FABP7, AQP7, EHHADH, ACOX1, LPL, PPARA, OLR1, SORBS1, ACADL, CD36, CYP27A1, FABP3, FADS2, SCP2, ILK, ACOX2, FABP6, ACSL5, CPT1C, SLC27A2, CPT2, GK, PLTP, ME1",0.899629454882437,0.271646217978772,FALSE +"H1703","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.32686,-1.21,0.211,16280,0.56,"CYP7B1, CYP27A1, SCP2, CYP39A1, ACOX2",0.675717544702307,0.2518119729938,FALSE +"H1703","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.37858,1.22,0.183,3722,0.576,"TAP2, RFX5, TAP1, IKBKG, ADA, UNG, CD40, RFXANK, RFXAP",0.737548910269571,0.239577516576788,FALSE +"H1703","Input","KEGG_PRION_DISEASES",0.1923,0.619,0.961,3665,0.994,"MAPK1, CCL5, MAP2K2, HSPA1A, PRKACA, BAX",0.0172766123314547,0.00261361560268669,FALSE +"H1703","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.45689,1.48,0.0605,3567,0.42,"CCNB3, MAPK11, MAPK12, RPS6KA6, MAPK9, HSP90AB1, CPEB1, MAD2L2, MAPK8, ADCY3, MAPK1, CDC25B, AKT1, KRAS, RAF1, CDC25A, CCNB1, PRKACA, CDC27, MAPK14, ANAPC1, ANAPC7, CCNA2, ANAPC4, FZR1, PKMYT1, CDC23, AKT3",1.21824462534753,0.3767507096021,FALSE +"H1703","Input","KEGG_PROPANOATE_METABOLISM",-0.39651,-1.42,0.0686,16714,0.521,"HIBCH, LDHAL6B, ACSS3, LDHA, ABAT, ACSS1, MLYCD, ALDH2, MCEE, ACSS2, ALDH6A1",1.16367588429325,0.283162276700476,FALSE +"H1703","Input","KEGG_PROSTATE_CANCER",0.3573,1.14,0.273,2759,0.612,"PDGFRA, PDGFC, PDGFB, HSP90AB1, SRD5A2, FGFR1, GRB2, E2F2, MTOR, EP300, CHUK, MAPK1, E2F3, NFKB1, E2F1, IKBKG, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, PTEN",0.563837352959244,0.213248577854439,FALSE +"H1703","Input","KEGG_PROTEASOME",0.38944,1.26,0.149,5852,0.592,"PSMD4, PSMB4, PSMB9, PSME3, PSMC5, PSMD12, PSMF1, PSMD1, PSMA2, PSMD14, PSMD3, PSMB10, PSMD11, PSMD2, PSMA5, PSMB8, PSMA4, PSMC2, PSMB1, SEM1, PSME2",0.826813731587726,0.22767829327708,FALSE +"H1703","Input","KEGG_PROTEIN_EXPORT",0.37758,1.21,0.209,3938,0.571,"SEC63, SRP19, SRP9, SRP72, SEC61A2, SEC11C, SRP68, SRPRB",0.679853713888946,0.243363891754152,FALSE +"H1703","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.14865,0.478,0.998,4853,0.998,"PCK2, ATP1A3, GLUD1, SLC25A10, SLC9A3",0.000869458712628891,0.000869458712628891,FALSE +"H1703","Input","KEGG_PURINE_METABOLISM",0.36229,1.17,0.216,4293,0.565,"PDE4A, NT5C2, POLR3C, PFAS, ADSL, POLR3G, ADK, PRPS1, PDE6C, POLA1, ATIC, HPRT1, NME4, NME2, ENTPD8, POLR1E, POLD2, POLR2J, GART, ADCY3, POLD1, NME1, POLR1C, ADA, POLR2E, NUDT5, PRUNE1, PRIM2, AMPD2, NME6, POLR3H, IMPDH2, GUK1, POLR2H, POLR2F, RRM2, PDE9A, GMPS, POLE, ENTPD1, POLR2B, POLR2J2, DCK, POLR3GL, RRM2B, PDE10A, PAICS, POLR3A, POLR3K, POLE2, PAPSS2, NUDT2, POLR2A, NME3",0.665546248849069,0.247951552180562,FALSE +"H1703","Input","KEGG_PYRIMIDINE_METABOLISM",0.50444,1.61,0.0298,4293,0.452,"NT5C2, TXNRD1, POLR3C, POLR3G, CAD, POLA1, CTPS1, DPYS, NME4, NME2, TYMS, ENTPD8, POLR1E, POLD2, POLR2J, UCK2, POLD1, NME1, POLR1C, UPP2, POLR2E, PRIM2, NME6, POLR3H, UMPS, POLR2H, POLR2F, RRM2, DCTD, DUT, POLE, UPRT, ENTPD1, POLR2B, POLR2J2, DCK, POLR3GL, RRM2B, POLR3A, UPP1, POLR3K, POLE2, NUDT2, POLR2A, NME3",1.52578373592374,0.344861565188618,FALSE +"H1703","Input","KEGG_PYRUVATE_METABOLISM",-0.27456,-1,0.43,18483,0.639,"ACSS1, ALDH2, ACSS2, ME1, PC",0.366531544420413,0.1944991418416,FALSE +"H1703","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.34257,1.1,0.299,3352,0.599,"PDGFRA, FGF17, APC2, PDGFC, CHRM4, PDGFB, GIT1, RAC1, ITGAM, PFN1, PAK2, PFN4, ENAH, MYL12B, PIP4K2B, VCL, ROCK1, FGF2, FGF5, SSH1, FGFR1, PIP5K1A, WASF1, APC, GNA13, CRKL, FGF12, TMSB4Y, CSK, MAPK1, CRK, CYFIP1, ARPC1B, KRAS, FGF8, SOS1, RAF1, NRAS, MYH9, MAP2K2, RRAS, MRAS, FGD1, DIAPH3, IQGAP1, WASF2, MYL12A, DOCK1, RHOA, ARPC5",0.52432881167557,0.222573177610689,FALSE +"H1703","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.45818,1.46,0.0764,3091,0.395,"ATG5, ATG7, PRKAA1, ULK2, ULK1, GABARAPL1, BECN1, PIK3C3",1.11690664142431,0.40340290437354,FALSE +"H1703","Input","KEGG_RENAL_CELL_CARCINOMA",0.39768,1.28,0.139,2591,0.62,"VEGFD, PDGFB, RAC1, ARNT, PAK2, ETS1, GRB2, CRKL, EGLN1, PTPN11, EP300, VHL, MAPK1, CRK, RAPGEF1, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2",0.856985199745905,0.207608310501746,FALSE +"H1703","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.32245,1.01,0.432,1261,0.676,"NLN, LNPEP",0.364516253185088,0.170053304058364,FALSE +"H1703","Input","KEGG_RETINOL_METABOLISM",-0.22451,-0.831,0.633,11025,0.751,"UGT2B11, CYP4A11, DHRS4L2, ADH6, CYP2A13, ADH1B, RDH8, UGT2B4, ADH7, UGT2B17, CYP1A2, ADH1A, UGT2A3, AWAT2, UGT2A1, UGT2B15, CYP2A7, RDH10, CYP2B6, RPE65, CYP4A22, CYP3A7, ADH1C, CYP2A6, RDH16, RDH5, UGT2B7, RETSAT, DHRS9, CYP3A5, BCO1, LRAT, ALDH1A2, CYP1A1, CYP26B1, RDH11, DHRS3",0.198596289982645,0.124360062995832,FALSE +"H1703","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.20606,-0.744,0.836,3935,0.872,"MTMR1, ACP6, MTMR6, RFK, ACP1, FLAD1, ACP2, ACP4, PHPT1, MTMR2, TYR, ENPP3, ENPP1, ACP5, MTMR7",0.0777937225609836,0.0594835150674328,FALSE +"H1703","Input","KEGG_RIBOSOME",-0.25121,-0.927,0.528,15661,0.673,"RPS8, RPL10A, RPL18, RPL7A, RPL35, RPL31, RPS3, RPL37A, RPL24, RPS15A, RPL29, RPS21, RPS6, RPS19, RPS27, RPS11, RPL13A, RPS9, RPLP2, RPS13, RPL27A",0.277366077466188,0.171984935776023,FALSE +"H1703","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.38127,1.21,0.198,4518,0.571,"MAPK11, MAPK12, ATG5, DDX3Y, MAPK9, MAP3K7, TRAF3, MAPK8, CHUK, TBKBP1, AZI2, NFKB1, IKBKG, RIPK1, IFNW1, MAPK14, TRIM25, DHX58, NFKBIB, TRAF2, NFKBIA, IKBKE, SIKE1, ATG12, IRF3",0.703334809738469,0.243363891754152,FALSE +"H1703","Input","KEGG_RNA_DEGRADATION",0.48273,1.56,0.0354,6697,0.434,"LSM1, EXOSC1, TENT4A, MTREX, HSPA9, EXOSC7, EXOSC3, DCP1B, CNOT10, LSM4, EDC4, ENO1, LSM2, EXOSC10, DCP2, EXOSC2, LSM6, EXOSC8, ZCCHC7, PAPOLB, LSM5, LSM3, PAPOLA, XRN1, SKIV2L, LSM7, EXOSC6, TTC37, EXOSC4, PARN, CNOT8, EXOSC9, CNOT9, XRN2, ENO3, CNOT1, PATL1, CNOT6",1.45099673797421,0.362510270487489,FALSE +"H1703","Input","KEGG_RNA_POLYMERASE",0.53681,1.75,0.0214,4251,0.322,"POLR3C, POLR3G, POLR1E, POLR2J, POLR1C, POLR2E, POLR3H, POLR2H, POLR2F, POLR2B, POLR2J2, POLR3GL, POLR3A, POLR3K, POLR2A",1.66958622665081,0.492144128304169,FALSE +"H1703","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.2498,0.807,0.746,4494,0.838,"SEPHS1, CBS, BUD23, AHCY, PAPSS2, METTL6, SCLY",0.127261172527331,0.0767559813697235,FALSE +"H1703","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.26392,0.857,0.649,6164,0.805,"LAMC3, PIAS3, BIRC3, TRAF3, E2F2, BIRC2, CHUK, E2F3, NFKB1, LAMB2, E2F1, IKBKG, PIAS2, AKT1, XIAP, CYCS, PTEN, AKT3, TRAF1, TRAF5, RB1, LAMA5, TRAF2, NFKBIA, CCNE2, PIK3CB, CDKN1B, IKBKB, CDK2, PIAS4, PIAS1, ITGAV, ITGA3, RELA, CKS1B, TRAF4, ITGB1",0.187755303199631,0.0942041196321315,FALSE +"H1703","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.3296,1.07,0.331,4551,0.61,"VAMP7, VAMP1, STX10, SNAP29, STX6, STX4, STX8, SNAP47, STX2, STX11, VTI1B, YKT6, GOSR2, VAMP2, STX1B, STX7",0.480172006224281,0.214670164989233,FALSE +"H1703","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.20482,-0.774,0.765,18902,0.849,"PLPP3, SMPD1, ASAH1",0.116338564846382,0.0710923097560473,FALSE +"H1703","Input","KEGG_SPLICEOSOME",0.58676,1.89,0.00623,4883,0.218,"MAGOHB, WBP11, SF3B4, TXNL4A, HSPA1L, PLRG1, RBM8A, PRPF8, THOC1, SNU13, RBM22, SNRPC, RBM17, SNRPD1, DHX16, HNRNPU, PRPF3, U2SURP, EFTUD2, DDX39B, ZMAT2, BUD31, SF3B5, ALYREF, PHF5A, SRSF1, HNRNPM, DDX46, PPIH, SF3A1, SNRPD3, LSM4, SRSF7, DDX42, CDC5L, SRSF3, CDC40, CCDC12, PPIL1, HSPA1A, SNRNP40, TCERG1, HNRNPA3, RBM25, LSM2, PUF60, THOC2, PRPF18, SMNDC1, LSM6, U2AF2, PRPF31, SNRPE, SRSF9, LSM5, TRA2A, NCBP1, DHX38, SART1, PRPF40A, PRPF40B, HSPA8, LSM3, U2AF1, SRSF2, HSPA1B, EIF4A3, SRSF4, AQR, SNRNP70, PRPF4, PQBP1",2.20551195334083,0.661543506395395,TRUE +"H1703","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.33823,-1.23,0.193,11025,0.574,"UGT2B11, AMY1C, AMY1A, PGM2, GBE1, UGT2B4, UGT2B17, MGAM, UGT2A3, UGT2A1, AMY2B, UGT2B15, PYGB, UXS1, PYGM, GYS1, TREH, UGP2, GANC, ENPP3, ENPP1, AGL, UGT2B7, GCK, UGDH, HK2, PGM2L1, GAA",0.714442690992226,0.241088107602027,FALSE +"H1703","Input","KEGG_STEROID_BIOSYNTHESIS",0.34437,1.1,0.304,1535,0.599,"SOAT1, CYP27B1, NSDHL",0.517126416391246,0.222573177610689,FALSE +"H1703","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.31975,-1.16,0.271,15701,0.568,"CYP19A1, UGT2B7, CYP11A1, CYP3A5, AKR1C1, CYP7B1, HSD17B2, HSD11B2, HSD17B7, AKR1C2, STS, CYP1B1, HSD17B12, AKR1C3, CYP1A1, HSD17B8",0.567030709125594,0.245651664288981,FALSE +"H1703","Input","KEGG_SULFUR_METABOLISM",-0.25162,-0.972,0.468,16233,0.669,"BPNT1, SULT1A2, SULT1A4, SULT1A1",0.329754146925876,0.174573882232177,FALSE +"H1703","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.33097,1.08,0.322,2327,0.625,"GRIN2B, ELANE, SNRPD1, CD40, SNRPD3",0.492144128304169,0.204119982655925,FALSE +"H1703","Input","KEGG_TASTE_TRANSDUCTION",0.49432,1.6,0.0281,1140,0.429,"TAS2R9, TAS2R7, TAS2R10, CACNA1A, TAS2R8, GNG13, TAS2R13",1.55129368009492,0.367542707815276,FALSE +"H1703","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.45807,-1.71,0.0273,15251,0.372,"GGT6, GGT5, CDO1, GGT7",1.56383735295924,0.429457060118102,FALSE +"H1703","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.34401,1.11,0.283,4402,0.616,"PDSS2, ACAT1, ACAT2, GGPS1, HMGCS1",0.54821356447571,0.210419287835575,FALSE +"H1703","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28573,0.931,0.545,5434,0.753,"SMAD2, NOG, BMPR1A, PPP2CA, ROCK1, BMP6, SMURF2, TGFBR2, EP300, MAPK1, SMAD4, SMAD1, CHRD, ZFYVE16, E2F5, BMP7, RPS6KB1, RHOA, SP1, ID3, TGFB1, BMP8A, CREBBP, SMAD3, SMURF1, SMAD5, ID1, ROCK2, BMPR2, TFDP1, RBX1, E2F4",0.263603497723358,0.123205023799299,FALSE +"H1703","Input","KEGG_THYROID_CANCER",0.2996,0.961,0.496,2591,0.746,"MAPK1, CCDC6, TPM3, KRAS, NRAS, MAP2K2",0.304518323509803,0.127261172527331,FALSE +"H1703","Input","KEGG_TIGHT_JUNCTION",0.26716,0.857,0.66,4727,0.805,"MYH2, MAP3K20, PPP2R2C, EXOC3, MYL12B, PPP2CA, VAPA, TJAP1, YBX3, AKT1, KRAS, OCLN, CSNK2B, CTNNA1, NRAS, MYH3, JAM3, MYH9, RRAS, AFDN, MRAS, PTEN, CLDN15, YES1, RAB3B, MYL12A, RHOA, EPB41L2, PRKCA, PARD6A, AKT3, PRKCI, GNAI2, MYH1, LLGL1, MYH10, SYMPK, PRKCQ, CTNNB1, CGN",0.180456064458131,0.0942041196321315,FALSE +"H1703","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.31496,1,0.422,4518,0.69,"MAPK11, MAPK12, RAC1, MAPK9, MAP3K7, TRAF3, MAPK8, IFNAR2, CHUK, MAPK1, NFKB1, IKBKG, TAB1, CD40, AKT1, CCL5, RIPK1, IRAK1, MAP2K2, MAPK14, TICAM1, FOS, AKT3, MAP2K3, TAB2, MYD88, CTSK, NFKBIA, IKBKE, IRF5, IRF3",0.374687549038326,0.161150909262745,FALSE +"H1703","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.29761,-1.1,0.311,14864,0.651,"EHHADH, AADAT, AOC1, AFMID, IDO1, DDC, IL4I1, KMO, MAOB, OGDHL, AOX1, CYP1B1, CYP1A1, MAOA, ALDH2, CAT",0.507239610973163,0.186419011431808,FALSE +"H1703","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.36991,1.2,0.203,3347,0.556,"CACNA1A, MAPK9, SOCS3, CACNA1G, MAPK8, MTOR, MAPK1, HK3, CACNA1B, SOCS2, MAFA",0.692503962086787,0.254925208417942,FALSE +"H1703","Input","KEGG_TYPE_I_DIABETES_MELLITUS",-0.25506,-0.939,0.481,14053,0.692,"TNF, FAS, CD86, CPE, GZMB, IL1A, PTPRN2, IL1B",0.317854923626168,0.159893905543242,FALSE +"H1703","Input","KEGG_TYROSINE_METABOLISM",0.27013,0.859,0.639,1909,0.817,"AOC2, AOC3, GOT1, BUD23, ADH5",0.1944991418416,0.0877779434675845,FALSE +"H1703","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.37218,1.19,0.21,3697,0.555,"MALT1, MAPK11, MAPK12, NFATC1, MAP3K14, PAK2, MAPK9, NFKBIE, MAP3K7, GRB2, CBL, CHUK, MAPK1, NFKB1, IKBKG, AKT1, KRAS, PPP3R2, SOS1, RAF1, NRAS, MAP2K2, PPP3CB, MAPK14, RHOA, FOS, AKT3, NFKBIB",0.677780705266081,0.255707016877324,FALSE +"H1703","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.39987,1.29,0.145,5645,0.617,"HERC4, UBE2G1, BTRC, NEDD4, TRIM37, PIAS3, FBXO2, SOCS3, UBE2K, NEDD4L, UBE2D2, BIRC3, SMURF2, TRIP12, UBE2A, CUL4A, CBL, FBXW11, BIRC2, CDC34, VHL, UBE2J1, PIAS2, BRCA1, XIAP, CDC20, BIRC6, UBE2R2, UBA2, CDC27, UBE2D1, COP1, UBE2Z, ANAPC1, NHLRC1, CUL4B, ANAPC7, ANAPC4, FZR1, PPIL2, CDC23, UBE2E1, UBE2E2, SIAH1, UBE2S, UBE2J2, UBE2L3, UBE2Q1, CUL7, ELOC, CUL2, UBE2B, UBE2G2, SMURF1, ERCC8, UBE2M, UBE4B, UBR5, ELOB, RBX1, PIAS4, FBXW7, UBE2D4, PIAS1, CDC16, ITCH, UBE2D3, CUL3",0.838631997765025,0.209714835966758,FALSE +"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.45454,1.46,0.0591,4778,0.395,"PDHA1, IARS2, BCAT2, VARS2",1.22841251911874,0.40340290437354,FALSE +"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.33547,-1.28,0.121,17618,0.507,"AOX1, ABAT, DBT, BCAT1, ALDH2, MCEE, ACADS, ALDH6A1",0.91721462968355,0.294992040666664,FALSE +"H1703","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.1626,0.534,0.996,3616,1,"ITPR2, KCNMA1, ROCK1, ADORA2A, GNA13, PLCB3, CALML6, PLCB4, ADCY3, MAPK1, RAF1, MAP2K2, PRKACA, RHOA, PRKCA, CALM3, GNA11",0.00174066157630127,0,FALSE +"H1703","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.27399,-1.01,0.415,17000,0.633,"RAB5B, ADCY9, CREB3L4, CREB3L1, DYNC1I1, AQP3, CREB5, ARHGDIB, CREB3L2, DCTN6",0.381951903287907,0.198596289982645,FALSE +"H1703","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.33163,1.07,0.348,4409,0.61,"MAPK11, MAPK12, NFATC1, RAC1, HSPB1, MAPK1, AKT1, KRAS, PPP3R2, RAF1, NRAS, MAP2K2, PPP3CB, MAPK14, PRKCA, AKT3, PXN, NFAT5, PLCG2, BAD",0.458420756053419,0.214670164989233,FALSE +"H1703","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.19574,-0.714,0.828,15082,0.903,"ATP6V0D2, CFTR, ATP6V1C2, ATP6V1G1, ATP6V1F, PDIA4, ATP6V0B, ATP6V0D1, PLCG1, ATP6V0A4, SEC61B, ADCY9, ATP6V1H, ATP6V1A, ATP6V1B2, TJP2",0.0819696632151199,0.0443122496864942,FALSE +"H1703","Input","KEGG_VIRAL_MYOCARDITIS",0.31847,1.04,0.381,2602,0.652,"MYH2, RAC1, CXADR, DAG1, CD40, CYCS, MYH3, MYH9, EIF4G1, BID",0.419075024324381,0.18575240426808,FALSE +"H1703","Input","KEGG_WNT_SIGNALING_PATHWAY",0.31753,1.03,0.39,3422,0.657,"APC2, CCND2, PPP2R5A, NFATC1, RAC1, SMAD2, BTRC, WNT5B, MAPK9, PPP2CA, ROCK1, NKD2, RUVBL1, MAP3K7, APC, MAPK8, FBXW11, PLCB3, EP300, PPP2R5D, PLCB4, CACYBP, CSNK1A1, PPP3R2, LRP6, CSNK2B, CTBP1, VANGL1, SMAD4, DVL1, PPP3CB, DVL2, WNT6, PRKACA, PPP2R5E, NLK, RHOA, PRKCA",0.408935392973501,0.182434630440219,FALSE +"HCC15","Input","KEGG_ABC_TRANSPORTERS",0.44979,1.41,0.0884,2887,0.382,"ABCG2, ABCC2, ABCG1, ABCB10, ABCC1, ABCC3, ABCB6, ABCA3, ABCD1, ABCC6, ABCA7",1.05354773498693,0.417936637088291,FALSE +"HCC15","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.28805,0.9,0.59,5403,0.942,"KIT, CHUK, PPARD, AKT1, ARAF, IKBKG, MAP2K1, MTOR, RELA, LEF1, JUP, HRAS, AKT2, NRAS, PML, SOS1, PIK3R1, SOS2, PIM1, TCF7, TCF7L2",0.229147988357856,0.0259490972071227,FALSE +"HCC15","Input","KEGG_ADHERENS_JUNCTION",-0.23557,-0.872,0.553,18295,1,"PTPRF, CTNNB1, CSNK2A1, SNAI2, WASF3, TGFBR1, ACTN1, NECTIN3, EP300, INSR, FYN",0.257274868695302,0,FALSE +"HCC15","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.45547,1.44,0.068,4975,0.368,"PRKAB1, TNFRSF1B, POMC, CHUK, PRKAA2, SLC2A1, MAPK8, TRAF2, PPARA, ADIPOR1, PRKCQ, AKT1, G6PC2, IKBKG, NFKBIA, IRS1, TNFRSF1A, MTOR, RELA, CPT1A, LEPR, MAPK9, AKT2, NFKBIB, ADIPOR2, RXRA, PRKAA1, ACACB",1.16749108729376,0.434152181326482,FALSE +"HCC15","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.21768,-0.812,0.712,17925,0.966,"IL4I1, GFPT2, ABAT, GLUL",0.147520006363144,0.0150228735845067,FALSE +"HCC15","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.21922,0.694,0.89,1535,0.997,"PDPK1, INS, ATP1B1, SGK1, FXYD4",0.0506099933550872,0.00130484168834428,FALSE +"HCC15","Input","KEGG_ALLOGRAFT_REJECTION",-0.21117,-0.786,0.774,4032,0.958,"FAS, CD40, IL10, GZMB, IL5, IFNG, FASLG, PRF1, CD40LG, IL2, CD28, CD80, IL4, CD86, TNF, IL12B, IL12A",0.111259039317107,0.0186344909214556,FALSE +"HCC15","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.68384,2.18,0,1,0.119,"PLA2G1B",Inf,0.924453038607469,TRUE +"HCC15","Input","KEGG_ALZHEIMERS_DISEASE",0.24113,0.767,0.824,4667,1,"NDUFS3, IDE, ITPR1, CASP9, CALM3, CHP1, APAF1, CALM1, CASP7, ATP5F1B, CAPN1, NDUFA9, NAE1, ATP2A2, NDUFV3, CASP8, COX5A, ITPR3, TNFRSF1A, NDUFB10, ATP5PO, NDUFA2, PPP3R1, COX7A2, NDUFB1, GAPDH, ATP5F1C, NDUFS1, PSEN2, BID, NDUFAB1, CAPN2, ATP5MC3, ATP5F1D, ADAM17, COX8A, FAS, ATF6, NCSTN, CALML6, ATP5MC2, CYC1, COX4I1, SDHD",0.0840727883028842,0,FALSE +"HCC15","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.49543,1.55,0.0376,3522,0.336,"IARS2, EARS2, PSTK, FARSB, SEPSECS, RARS2, MTFMT, SARS2, YARS2",1.42481215507234,0.473660722610156,FALSE +"HCC15","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.34327,1.09,0.333,5776,0.702,"GNPNAT1, UGDH, PGM3, GNPDA2, PMM2, GALK2, GPI, GFPT1, GALE, FPGT, HK3, NANS, GMDS, HK1, HEXB, PGM2, UXS1, PGM1, CMAS, HEXA",0.47755576649368,0.153662887870195,FALSE +"HCC15","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.41376,1.32,0.124,3725,0.387,"TNFRSF1B, TOMM40, CASP9, CHP1, APAF1, SOD1, MAPK14, BCL2L1, MAP2K6, MAPK13, TNFRSF1A, MAP3K5, PPP3R1, BID",0.906578314837765,0.412289034981089,FALSE +"HCC15","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.18466,0.583,0.981,6720,1,"NFYC, PSME2, B2M, CTSL, KLRC3, HSP90AA1, LGMN, HSP90AB1, KLRC2, PSME1, HSPA2, HSPA1A, HSPA8, PDIA3, CANX, IFI30, NFYA, HSPA5, HSPA4",0.0083309926200515,0,FALSE +"HCC15","Input","KEGG_APOPTOSIS",0.43088,1.39,0.103,4034,0.382,"CHUK, IL3RA, CASP9, IRAK3, CHP1, APAF1, IRAK4, TRAF2, IRAK2, CASP7, ATM, AKT1, BCL2L1, CAPN1, IKBKG, NFKBIA, TNFRSF10A, MAP3K14, CASP8, CASP10, PRKACB, TNFRSF1A, RELA, PPP3R1, RIPK1, BID, CAPN2, AKT2, ENDOD1, FAS, PRKAR2A",0.987162775294828,0.417936637088291,FALSE +"HCC15","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.53006,1.66,0.0233,1901,0.25,"PLA2G1B, LTA4H, CYP4F3, GGT5, PTGES, AKR1C3, PLA2G4A, GPX4, CBR1, GGT1",1.63264407897398,0.602059991327962,FALSE +"HCC15","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.31591,1.02,0.404,4880,0.81,"CPS1, AZIN2, SAT1, ALDH9A1, SRM, GLUD1, GAMT, ALDH3A2, ARG2, ALDH2, GOT2, MAOA, ODC1, AGMAT, CKB, OAT, ALDH18A1, ALDH7A1, ALDH4A1",0.393618634889395,0.0915149811213502,FALSE +"HCC15","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.22285,-0.863,0.639,15744,1,"CACNA1C, ACTN2, CACNA2D2, LAMA2, CACNA2D3, ITGA7, RYR2, CACNB4, CACNA1D, CACNG4, ITGA4, SLC8A1, ITGB3, DMD, CACNA2D1, CTNNB1, ACTN1, ITGB8, CACNB1, CACNB3",0.1944991418416,0,FALSE +"HCC15","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.41692,1.32,0.119,3177,0.387,"UGDH, ALDH9A1, ALDH3A2, ALDH2",0.924453038607469,0.412289034981089,FALSE +"HCC15","Input","KEGG_ASTHMA",-0.18282,-0.677,0.93,3491,0.942,"IL13, CD40, FCER1A, IL10, IL5, IL9, MS4A2, CD40LG, IL3, FCER1G, CCL11, IL4, PRG2, RNASE3, TNF, EPX",0.0315170514460649,0.0259490972071227,FALSE +"HCC15","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.25945,0.817,0.745,14161,1,"FAS, CD40, IL10, GZMB, TPO, IL5, CTLA4, IFNA4, IFNA17, IFNA6, IFNA16, FASLG, IFNA10, IFNA2, IFNA7, PRF1, IFNA14, CD40LG, IL2, CD28, TSHB, IFNA1, CD80, IFNA13, IL4, CGA, IFNA21, TG, IFNA8, IFNA5, TSHR, CD86",0.127843727251707,0,FALSE +"HCC15","Input","KEGG_AXON_GUIDANCE",-0.33687,-1.26,0.141,15481,1,"EPHA7, FES, UNC5A, EPHA6, PAK3, SEMA3G, EFNA4, ROBO2, CXCL12, DPYSL5, EPHA3, EPHA4, EPHA5, DPYSL2, PAK2, EPHB2, EPHA1, SEMA6D, NTNG1, EPHB1, SRGAP1, PLXNC1, CXCR4, SEMA3D, SEMA3E, NFATC2, SEMA5A, SEMA6C, SLIT2, SEMA6A, SEMA4A, NTN1, EFNB3, PLXNB2, EFNB1, PLXNA2, UNC5B, EFNA3, PLXNB3, SEMA3A, SRGAP3, LIMK2, NFATC1, SEMA7A, L1CAM, ROBO1, FYN, ROBO3, PLXNB1, GSK3B",0.85078088734462,0,FALSE +"HCC15","Input","KEGG_BASAL_CELL_CARCINOMA",-0.18834,-0.719,0.869,15472,0.912,"WNT2B, WNT7A, PTCH2, APC2, HHIP, GLI1, DVL2, WNT10A, WNT10B, WNT5A, DVL3, FZD8, WNT7B, CTNNB1, GSK3B",0.0609802235513335,0.0400051616715838,FALSE +"HCC15","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.46988,1.49,0.0561,2124,0.37,"TAF1L, GTF2H1, GTF2A1, TAF12, TAF9, TBPL1, GTF2H3, TBP, GTF2IRD1",1.25103713874384,0.431798275933005,FALSE +"HCC15","Input","KEGG_BASE_EXCISION_REPAIR",0.35265,1.12,0.285,6586,0.675,"POLE2, TDG, POLE3, PARP4, POLD3, OGG1, LIG1, FEN1, POLD1, UNG, NEIL1, POLL, POLE4, LIG3, NEIL3, APEX2, NTHL1",0.54515513999149,0.170696227168975,FALSE +"HCC15","Input","KEGG_BETA_ALANINE_METABOLISM",0.3441,1.09,0.322,4736,0.702,"HADHA, ALDH9A1, HIBCH, SRM, ALDH3A2, ALDH2, ECHS1, GAD1, ALDH7A1",0.492144128304169,0.153662887870195,FALSE +"HCC15","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29902,0.931,0.538,4664,0.922,"HADHA, HACD1, ACOT7, ACOX1, PECR, YOD1, FADS1",0.269217724333611,0.0352690789463706,FALSE +"HCC15","Input","KEGG_BLADDER_CANCER",-0.30586,-1.08,0.356,15843,0.909,"RAF1, MMP9, VEGFA, ERBB2, FGFR3, CDKN1A, DAPK2, MMP1, MAP2K2, VEGFB, PGF, MMP2, CDKN2A, DAPK3, DAPK1, RB1",0.448550002027125,0.0414361167780325,FALSE +"HCC15","Input","KEGG_BUTANOATE_METABOLISM",0.35252,1.11,0.296,4736,0.681,"HADHA, ALDH9A1, ALDH3A2, ACAT1, AACS, ALDH2, ACADS, ALDH5A1, L2HGDH, ECHS1, GAD1, ACSM4, ALDH7A1",0.528708288941061,0.166852888087215,FALSE +"HCC15","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.2376,0.751,0.824,4450,1,"NFAT5, CHUK, SYK, IFITM1, CHP1, LYN, AKT1, NFATC3, IKBKG, NFKBIA, MAP2K1, RELA, CD22, PPP3R1, HRAS, AKT2, NRAS, PTPN6, NFKBIB, SOS1",0.0840727883028842,0,FALSE +"HCC15","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.16516,0.514,0.997,3531,1,"NTSR1, ITPR1, GNAL, CALM3, VDAC2, CHP1, ADCY9, ADCY7, CALM1, GNA15, P2RX5, MYLK2, PLCD4, PHKB, ATP2A2, PHKA1, PRKACB, ITPR3, PTK2B, PPP3R1, VDAC1, ITPKA, ITPKB",0.00130484168834428,0,FALSE +"HCC15","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.36529,-1.33,0.139,14113,1,"COX7B2, ATP1B2, MYL2, TPM4, ATP1A2, UQCR11, FXYD2, TNNC1, UQCRHL, COX8C, CACNG7, CACNA1C, TNNT2, CACNA2D2, CACNA2D3, RYR2, CACNB4, COX6B2, UQCRC1, CACNA1D, CACNG4, COX5B, UQCR10, COX6C, SLC8A1, TPM1, ATP1A3, COX7C, UQCRB, CACNA2D1, TPM2, CACNB1, CACNB3",0.856985199745905,0,FALSE +"HCC15","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.25305,-0.95,0.45,15177,1,"VCAM1, CDH4, CLDN10, ITGA9, CDH3, CLDN16, NLGN4X, CNTNAP2, CLDN11, JAM2, NCAM2, NLGN3, CNTN1, ITGAM, NRXN2, JAM3, CD8A, CLDN22, SELL, PDCD1LG2, CADM1, NCAM1, NRXN3, NFASC, NLGN1, NECTIN1, ITGA4, NRCAM, ICOSLG, SDC2, PTPRF, NEO1, NECTIN3, ITGB8, L1CAM, SDC1",0.346787486224656,0,FALSE +"HCC15","Input","KEGG_CELL_CYCLE",0.455,1.42,0.0814,5635,0.389,"PTTG1, CCND3, CDC25C, CDC23, ORC1, TTK, PLK1, BUB3, ANAPC4, SMAD2, BUB1, CCNB1, ORC4, ORC3, PTTG2, CCNB2, MCM6, ANAPC5, PRKDC, CHEK1, SKP1, CDC6, ATM, E2F3, ABL1, MCM3, CDC7, SMC3, YWHAQ, CDK1, BUB1B, MCM4, HDAC1, CDC45, CDC20, SMC1A, ORC2, YWHAG, E2F2, CDC25B, ANAPC7, ESPL1, ORC6, E2F4, SFN, CDC27, CCNE2, CDK2, TGFB1, CDC14A, DBF4, CDC14B, CDK6, YWHAZ, CCNH, CDKN2C, CUL1, CCNA2, ANAPC2, RBL1, MCM7, WEE2, MAD2L2, CDK7, CDKN1C, ORC5, HDAC2, STAG2, CDKN1B, WEE1, RAD21",1.0893755951108,0.410050398674292,FALSE +"HCC15","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.20526,0.648,0.935,5017,1,"CCL5, CHUK, SHC1, ROCK2, SHC3, GNG11, GNB5, ADCY9, ADCY7, WASL, ARRB1, GSK3A, LYN, AKT1, IKBKG, NFKBIA, CCL28, MAP2K1, CDC42, CCL22, PRKACB, PTK2B, CXCL5, CCL2, RELA, HRAS, GNAI1, PXN, CXCL8, GNB1, GRK5, AKT2, GNAI3, NRAS, NFKBIB, SOS1, CCL14, PIK3R1, STAT2, GNG10, SOS2, RAP1B",0.0291883891274822,0,FALSE +"HCC15","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.26224,0.828,0.719,5826,1,"CHUK, SHC1, SHC3, E2F3, ABL1, AKT1, ARAF, HDAC1, BCL2L1, CTBP2, IKBKG, NFKBIA, MAP2K1, CBL, E2F2, RELA, HRAS, AKT2, NRAS, TGFB1, TGFBR2, SOS1, CDK6, PIK3R1, SOS2, HDAC2, CRK, CDKN1B, MAPK3, TGFB2",0.143271109617117,0,FALSE +"HCC15","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.33336,1.06,0.369,6488,0.742,"NPAS2, CSNK1E, ARNTL, PER2, NR1D1, PER1, CRY2",0.43297363384094,0.129596094720973,FALSE +"HCC15","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.2438,0.778,0.791,1292,1,"PC, DLAT, IDH3A",0.101823516502323,0,FALSE +"HCC15","Input","KEGG_COLORECTAL_CANCER",0.22631,0.706,0.897,5403,0.998,"CASP9, SMAD2, AXIN2, MAPK8, MSH2, AKT1, ARAF, APC, MAP2K1, MSH3, MSH6, APPL1, LEF1, MAPK9, AKT2, TGFB1, TGFBR2, PIK3R1, BIRC5, TCF7, TCF7L2",0.0472075569559079,0.000869458712628891,FALSE +"HCC15","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.3153,0.994,0.453,3883,0.83,"THBD, SERPIND1, C3AR1, CFH, CD46, TFPI, PLAUR, MASP2, F13A1, C5, PLAU, SERPINC1, CD59, CFD",0.343901797987168,0.0809219076239261,FALSE +"HCC15","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.46262,1.45,0.0802,3195,0.364,"BHMT, ADI1, MAT2A, MAT2B, TRDMT1, LDHA, SRM, AHCYL2, AHCYL1, APIP, GOT2",1.09582563171584,0.438898616350944,FALSE +"HCC15","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.17804,0.563,0.987,672,1,"TNFSF15, TNFRSF1B, CSF2RA, CCL5, EGF, TNFSF8, KIT, FLT4, CNTF, IL3RA, IFNGR1",0.00568284733036327,0,FALSE +"HCC15","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.34791,1.1,0.313,4369,0.697,"CCL5, CHUK, TBK1, IKBKG, POLR3K, NFKBIA, POLR3A, RELA, ZBP1, RIPK1, RIPK3, ADAR, POLR3B, POLR1C, NFKBIB, IL18",0.504455662453552,0.156767221901991,FALSE +"HCC15","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.22816,-0.853,0.669,14773,1,"SGCD, TNF, TNNC1, DES, CACNG7, ITGA9, ADCY1, CACNA1C, TNNT2, CACNA2D2, LAMA2, CACNA2D3, ADCY5, ITGA7, RYR2, CACNB4, CACNA1D, CACNG4, ITGA4, SLC8A1, ITGB3, TPM1, DMD, CACNA2D1, ITGB8, GNAS, TPM2, CACNB1, CACNB3",0.174573882232177,0,FALSE +"HCC15","Input","KEGG_DNA_REPLICATION",0.60201,1.89,0.00358,4243,0.23,"DNA2, MCM6, POLE2, RFC5, POLE3, MCM3, MCM4, POLA1, RFC2, PRIM1, POLA2, PRIM2, POLD3, RFC1, RPA2, RNASEH1, RPA1, LIG1, FEN1, POLD1",2.44611697335613,0.638272163982407,TRUE +"HCC15","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.15222,-0.592,0.971,16707,0.979,"ETV7, FMN2, NOTCH4, CPEB1",0.0127807700919951,0.00921730819686218,FALSE +"HCC15","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.15554,0.49,0.999,3621,0.997,"ALDH3A1, ALDH3B1, GSTM2, GSTM4, GSTM3, CYP3A5, MAOA, MGST1",0.000434511774017692,0.00130484168834428,FALSE +"HCC15","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.30544,-1.14,0.28,17562,0.962,"ITPA, XDH, UMPS, GMPS, NAT1, IMPDH2, UCKL1",0.552841968657781,0.0168249279621871,FALSE +"HCC15","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.2005,-0.758,0.844,15298,0.954,"COL11A1, LAMC1, ITGA9, RELN, COL5A3, COL6A1, LAMA2, COL6A3, THBS2, ITGA7, CHAD, COL1A2, COL4A2, FN1, THBS4, ITGA4, LAMA4, ITGB3, COL6A2, SV2A, SDC2, THBS3, LAMB1, ITGB8, SDC1, CD47",0.073657553374345,0.0204516252959049,FALSE +"HCC15","Input","KEGG_ENDOCYTOSIS",0.27333,0.87,0.645,4500,0.968,"DNM3, EGF, STAM, AP2S1, KIT, IQSEC2, RAB11FIP2, RAB11A, USP8, ARRB1, STAM2, SH3KBP1, SMAP1, AP2A2, VTA1, SMURF2, SMAP2, NEDD4, TSG101, GIT2, ASAP1, CBL, PIKFYVE, EEA1, CDC42, STAMBP, RUFY1, ACAP3, CHMP4C, VPS4A, ARAP2, ASAP2, CHMP4A, SH3GLB2, LDLRAP1, VPS37A, WWP1, DNAJC6, SH3GLB1, HRAS, CLTCL1, GRK5, CHMP1B, DNM1L, AP2B1, DNM1, ARFGAP2, RAB31, IGF1R, CLTB, RAB11FIP3",0.190440285364732,0.0141246426916063,FALSE +"HCC15","Input","KEGG_ENDOMETRIAL_CANCER",0.29474,0.93,0.543,5551,0.914,"EGF, PDPK1, CASP9, AXIN2, AKT1, CTNNA1, ARAF, APC, MAP2K1, LEF1, HRAS, AKT2, ILK, NRAS, SOS1, PIK3R1, ELK1, SOS2, TCF7, PTEN, TCF7L2, CDH1",0.265200170411153,0.0390538042661686,FALSE +"HCC15","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.44259,1.4,0.0749,4447,0.375,"CCL5, ATP6V0A4, CHUK, MAPK8, TJP1, LYN, MAPK14, ATP6V0E1, ATP6V1E1, ATP6V1C1, ATP6V0A1, ATP6V1H, IKBKG, ATP6V0B, NFKBIA, TCIRG1, ATP6V0D1, CDC42, MAP3K14, ATP6V0C, MAPK13, MAP2K4, RELA, ATP6V1A, ATP6V0E2, CXCL8, MAPK9, ADAM17, HBEGF, ATP6V1G1, ATP6V0A2",1.12551818230053,0.425968732272281,FALSE +"HCC15","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.19345,-0.742,0.875,17973,0.901,"SHC2, MAPK10, EIF4EBP1, PIK3CD, MAP2K7, AKT3, PLCG1, PIK3R2, JUN, GSK3B, GAB1",0.0579919469776868,0.045275209020937,FALSE +"HCC15","Input","KEGG_ETHER_LIPID_METABOLISM",0.60914,1.94,0.00359,2363,0.218,"PLA2G1B, PAFAH2, PAFAH1B2, PAFAH1B3, PLA2G4A, PLPP3, CHPT1",2.44490555142168,0.661543506395395,TRUE +"HCC15","Input","KEGG_FATTY_ACID_METABOLISM",0.35784,1.12,0.279,3417,0.675,"HADHA, ECI1, HADHB, ACADSB, ALDH9A1, ALDH3A2, ACOX1, ACAT1, ALDH2, CPT1A, ACADS",0.554395796726402,0.170696227168975,FALSE +"HCC15","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.34356,1.07,0.348,3845,0.725,"PLA2G1B, SYK, PDPK1, MAPK8, LYN, MAPK14, AKT1, PLA2G4A, PRKCE, MAP2K1, MAP2K6, MAPK13, MAP2K4, IL13, HRAS, MAPK9, AKT2",0.458420756053419,0.139661993429006,FALSE +"HCC15","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.26261,0.818,0.727,4238,1,"DNM3, SYK, CFL2, ARPC2, WASL, ARPC5L, LYN, AKT1, PLA2G4A, WASF2, PLPP3, PRKCE, ARPC3, ASAP1, MAP2K1, PIKFYVE, CDC42, ASAP2, CFL1, MYO10, DNM1L, AKT2, LIMK1, DNM1, ARPC4",0.138465589140962,0,FALSE +"HCC15","Input","KEGG_FOCAL_ADHESION",0.18106,0.56,0.986,5638,1,"COL4A6, ITGA10, EGF, CCND3, FLT4, PDPK1, FLNB, SHC1, ROCK2, ITGA1, SHC3, COL3A1, MAPK8, DIAPH1, COL5A2, MYLK2, AKT1, ITGB5, MAP2K1, PARVA, CDC42, ARHGAP35, ITGB7, PPP1CC, COL4A4, ITGB4, ACTN4, ITGA2, HRAS, ARHGAP5, LAMB3, PXN, CAPN2, MAPK9, AKT2, ILK, PPP1CA, IGF1R, PPP1CB, SOS1, XIAP, ITGA6, ITGB1, PIK3R1, ELK1, SOS2, RAP1B, PTEN, BIRC2, LAMA1, RAPGEF1, PAK1, PRKCA, ITGA11, CRK, VCL, BIRC3, LAMB2, BCAR1",0.0061230850587888,0,FALSE +"HCC15","Input","KEGG_FOLATE_BIOSYNTHESIS",0.49637,1.57,0.0406,4914,0.323,"PTS, SPR, DHFR, GCH1, GGH, FPGS",1.39147396642281,0.490797477668897,FALSE +"HCC15","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.27561,0.882,0.63,6028,0.958,"PFKP, PMM2, MTMR2, ALDOA, FPGT, SORD, HK3, GMDS, HK1, KHK, MTMR7, MTMR6, PHPT1",0.200659450546418,0.0186344909214556,FALSE +"HCC15","Input","KEGG_GALACTOSE_METABOLISM",0.35175,1.12,0.282,3599,0.675,"GLA, PFKP, B4GALT1, G6PC2, GALK2, GALE, HK3",0.549750891680639,0.170696227168975,FALSE +"HCC15","Input","KEGG_GAP_JUNCTION",0.23255,0.727,0.859,5227,1,"TUBAL3, EGF, ITPR1, ADCY9, ADCY7, MAP3K2, TJP1, CDK1, LPAR1, MAP2K1, PRKACB, ITPR3, TUBB3, HRAS, GNAI1, GNAI3, NRAS, SOS1, TUBB2A, SOS2, TUBA1C, TUBB, TUBA4A, TUBA1B",0.0660068361687577,0,FALSE +"HCC15","Input","KEGG_GLIOMA",0.23961,0.765,0.812,4999,1,"EGF, SHC1, SHC3, CALM3, CALM1, E2F3, AKT1, ARAF, TGFA, MAP2K1, E2F2, MTOR, HRAS, AKT2, NRAS, IGF1R, SOS1, CALML6, CDK6, PIK3R1, CALM2, SOS2",0.0904439707588247,0,FALSE +"HCC15","Input","KEGG_GLUTATHIONE_METABOLISM",0.5227,1.64,0.0332,4965,0.259,"GCLC, PGD, GSR, GCLM, G6PD, GGT5, RRM1, TXNDC12, GPX4, SRM, GGT1, GSTM2, GSTM4, GSS, GSTM3, RRM2, ODC1, GPX7, MGST1, GPX3, MGST2, GSTO1, GSTK1, RRM2B",1.47886191629596,0.586700235918748,FALSE +"HCC15","Input","KEGG_GLYCEROLIPID_METABOLISM",0.35194,1.11,0.291,3355,0.681,"GLA, AGPAT3, DGKG, AKR1A1, ALDH9A1, PLPP3, GPAT3, ALDH3A2, DGKD, MBOAT1, ALDH2, TKFC",0.536107011014093,0.166852888087215,FALSE +"HCC15","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.43918,1.38,0.103,2870,0.368,"PLA2G1B, AGPAT3, PTDSS2, DGKG, PTDSS1, GPD2, LYPLA2, MBOAT7, PLA2G4A, ETNK1, PLPP3, GPAT3, LYPLA1, CHPT1, DGKD, GNPAT, MBOAT1",0.987162775294828,0.434152181326482,FALSE +"HCC15","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.25618,0.805,0.765,3612,1,"BHMT, DMGDH, GAMT, SHMT1, MAOA, DLD",0.116338564846382,0,FALSE +"HCC15","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.39976,1.25,0.153,4179,0.484,"ALDH3A1, ENO3, ENO1, PFKP, DLAT, AKR1A1, ALDH3B1, ALDH9A1, G6PC2, LDHA, ALDH3A2, GPI, PGAM1, GALM, PKM, ALDOA, ALDH2, GAPDH, HK3, DLD, ACSS2, LDHAL6B",0.815308569182401,0.315154638355588,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.29443,0.924,0.565,4809,0.91,"CHST15, CSGALNACT1, B3GAT3, DSE, CSGALNACT2, B3GAT2, CHST7",0.247951552180562,0.0409586076789064,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.27858,-1.02,0.385,15306,0.969,"HS3ST5, NDST3, B3GAT1, HS3ST3B1, B4GALT7, HS3ST1, HS3ST3A1, NDST1, XYLT1, HS6ST2, XYLT2, EXT1",0.414539270491499,0.0136762229492347,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.45621,-1.72,0.0244,17191,0.54,"B3GNT7, CHST2, FUT8, ST3GAL1, B3GNT2, B4GALT4, B4GALT2",1.61261017366127,0.267606240177031,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.44304,1.37,0.0947,6089,0.348,"HYAL1, GUSB, GALNS, GNS, ARSB, HGSNAT, NAGLU, HEXB, SGSH, HEXA, HYAL3",1.02365002099673,0.458420756053419,FALSE +"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.27762,-0.998,0.401,14743,0.981,"GLB1, B3GALT4, ST6GALNAC6, ST8SIA1, ST6GALNAC5, ST3GAL1, SLC33A1",0.396855627379818,0.0083309926200515,FALSE +"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.3276,1.02,0.392,71,0.81,"GLA",0.406713932979543,0.0915149811213502,FALSE +"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.32609,-1.23,0.192,16056,0.996,"B3GALT1, ABO, B3GALT5, FUT3, ST8SIA1, B3GNT2, ST3GAL6, B4GALT4, B4GALT2",0.71669877129645,0.00174066157630127,FALSE +"HCC15","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.3429,1.07,0.335,2640,0.725,"PIGN, PIGB, DPM2, PGAP1, PIGP, PIGU",0.474955192963155,0.139661993429006,FALSE +"HCC15","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.27868,0.869,0.642,2851,0.96,"PGP, CS",0.192464971931147,0.0177287669604316,FALSE +"HCC15","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.33809,1.07,0.347,3080,0.725,"PLA2G1B, ITPR1, CALM3, ADCY9, ADCY7, CALM1, MAPK8, MAP3K2, MAPK14, PLA2G4A, MAP2K1, CDC42, MAP2K6, PRKACB, MAPK13, ITPR3, PTK2B, MAP2K4",0.459670525209126,0.139661993429006,FALSE +"HCC15","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.23138,-0.852,0.658,9778,0.977,"IFNG, FASLG, PRF1, KIR2DL1, KIR3DL2, IL2, KLRD1, CD28, KIR3DL1, KIR2DL3, CD80, KLRC1, CD86, IL6, TNF, IL1B",0.181774106386044,0.0101054362812269,FALSE +"HCC15","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.19735,0.618,0.969,2636,1,"BTRC, CSNK1E, BMP4, CSNK1G1, GLI2, CSNK1G2, WNT3, PRKACB",0.0136762229492347,0,FALSE +"HCC15","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.2343,0.739,0.838,675,1,"CD14, CSF2RA, KIT, IL3RA, ITGA1",0.0767559813697235,0,FALSE +"HCC15","Input","KEGG_HISTIDINE_METABOLISM",0.4684,1.47,0.0548,5111,0.343,"AMDHD1, ALDH3A1, TRMT11, ALDH3B1, ALDH9A1, HAL, ALDH3A2, METTL2B, ALDH2, MAOA, BUD23, ALDH7A1, HDC, LCMT2, LCMT1",1.26121944151563,0.464705879957229,FALSE +"HCC15","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.43939,1.38,0.0858,5951,0.368,"XRCC3, RAD51, BLM, MRE11, RAD54B, POLD3, RPA2, MUS81, RAD54L, RPA1, NBN, XRCC2, POLD1, RAD50, RAD51D, RPA3, RPA4, TOP3A, EME1, RAD52",1.06651271215129,0.434152181326482,FALSE +"HCC15","Input","KEGG_HUNTINGTONS_DISEASE",0.26277,0.816,0.735,4667,1,"NDUFS3, RCOR1, AP2S1, POLR2J2, ITPR1, BDNF, CASP9, VDAC2, APAF1, SOD1, TGM2, ATP5F1B, AP2A2, POLR2E, TBPL1, HDAC1, DCTN4, TBP, SP1, NDUFA9, POLR2D, POLR2A, NDUFV3, CASP8, POLR2C, CREB3L2, COX5A, NDUFB10, ATP5PO, POLR2L, NDUFA2, VDAC1, COX7A2, NDUFB1, ATP5F1C, CLTCL1, NDUFS1, NDUFAB1, POLR2G, ATP5MC3, DNAH1, TFAM, ATP5F1D, COX8A, SIN3A, AP2B1, CLTB, ATP5MC2, CYC1, COX4I1, SDHD",0.133712660915805,0,FALSE +"HCC15","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.21991,-0.827,0.692,14165,1,"MYL2, SGCG, TPM4, PRKAG1, IGF1, IL6, SGCD, TNF, TNNC1, DES, CACNG7, PRKAG2, ITGA9, CACNA1C, ACE, TNNT2, CACNA2D2, LAMA2, CACNA2D3, ITGA7, RYR2, CACNB4, CACNA1D, CACNG4, ITGA4, SLC8A1, ITGB3, TPM1, DMD, CACNA2D1, ITGB8, TPM2, CACNB1, CACNB3",0.159893905543242,0,FALSE +"HCC15","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.23102,-0.862,0.619,17903,1,"PIP5K1C, PIK3C3, PLCE1, PIK3CD, ALDH6A1, INPP5J, PLCG1, PLCB1, INPP4B",0.208309350979882,0,FALSE +"HCC15","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.2936,0.925,0.571,4999,0.917,"PRKAB1, PDE3A, PPP1R3C, PRKAA2, PDPK1, MKNK2, SHC1, INS, SHC3, CALM3, CALM1, MAPK8, MKNK1, AKT1, ARAF, G6PC2, PHKB, MAP2K1, CBL, PHKA1, PRKACB, PPP1CC, IRS1, MTOR, SORBS1, ACACA, HRAS, HK3, MAPK9, AKT2, PRKAR2A, SOCS4, PPP1CA, NRAS, PPP1CB, SOS1, PHKG2, CALML6, HK1, TSC1, PIK3R1, PRKAA1, CALM2, ELK1, ACACB, SOS2",0.243363891754152,0.0376306643299789,FALSE +"HCC15","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.19757,-0.752,0.775,17241,0.937,"CXCR4, ITGA4, CCR10, ICOSLG, IL15",0.11069829749369,0.0282604091122217,FALSE +"HCC15","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.17092,0.536,0.987,5338,1,"CSF2RA, CCND3, STAM, CNTF, IL3RA, IFNGR1, STAM2, AKT1, SPRED2, BCL2L1, SPRED1, IL10RB, CBL, IL22RA1, SPRY4, PIAS1, IFNLR1, LEPR, IL13, AKT2, SOCS4, PTPN6, IL13RA1, IFNAR1, SPRY1, SOS1, PIK3R1, STAT2, OSMR, SOS2, PIM1, MPL, IFNAR2, IL4R, IL20RA",0.00568284733036327,0,FALSE +"HCC15","Input","KEGG_LEISHMANIA_INFECTION",0.18164,0.566,0.984,6037,1,"IFNGR1, IRAK4, MAPK14, NFKBIA, MAPK13, PTGS2, RELA, MAP3K7, TGFB1, PTPN6, NFKBIB, ITGB2, ITGB1, ELK1, TAB2, TRAF6, CYBA, MAPK3, TGFB2, IL10",0.00700490156865849,0,FALSE +"HCC15","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.20078,0.631,0.932,5638,1,"CLDN2, TXK, ROCK2, RASSF5, MAPK14, CTNNA1, SIPA1, CD99, CDC42, ARHGAP35, MAPK13, PTK2B, CLDN4, ACTN4, ARHGAP5, CTNND1, GNAI1, PXN, CLDN23, MSN, GNAI3, NOX1, ITGB2, ITGB1, PIK3R1, CLDN3, ESAM, CLDN20, RAP1B, EZR, PRKCA, ICAM1, CYBA, VCL, BCAR1",0.0305840876460186,0,FALSE +"HCC15","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.57214,1.75,0.0173,4736,0.353,"HADHA, ALDH9A1, ALDH3A2, ALDH2, ECHS1, YOD1, ALDH7A1",1.7619538968712,0.452225294612177,FALSE +"HCC15","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.59268,1.84,0.0105,1,0.243,"PLA2G1B",1.97881070093006,0.614393726401688,TRUE +"HCC15","Input","KEGG_LONG_TERM_DEPRESSION",0.41246,1.28,0.152,1786,0.443,"PLA2G1B, PPP2R1B, ITPR1, GNA13, PPP2R1A, LYN, ARAF, PLA2G4A",0.818156412055227,0.35359627377693,FALSE +"HCC15","Input","KEGG_LONG_TERM_POTENTIATION",0.22951,0.722,0.846,6597,1,"ITPR1, CALM3, CHP1, CALM1, ARAF, MAP2K1, PRKACB, PPP1CC, ITPR3, PPP3R1, HRAS, RPS6KA1, PPP1CA, NRAS, PPP1CB, CALML6, CALM2, RAP1B, PPP3CB, PRKCA, MAPK3, RAP1A, PPP1R12A, RPS6KA3, PLCB3, PPP3CC, GRIN1",0.0726296369609765,0,FALSE +"HCC15","Input","KEGG_LYSINE_DEGRADATION",0.43876,1.38,0.0995,4736,0.368,"HADHA, KMT5A, SUV39H1, AASDHPPT, ALDH9A1, EHMT1, ALDH3A2, SETD1B, ACAT1, ALDH2, SETD1A, TMLHE, PLOD1, ECHS1, SUV39H2, SETD7, EHMT2, ASH1L, NSD1, ALDH7A1",1.00217691925427,0.434152181326482,FALSE +"HCC15","Input","KEGG_LYSOSOME",0.40725,1.27,0.153,5776,0.453,"GLA, HYAL1, ATP6V0A4, AP1S3, AP4E1, AP3M1, AP3B1, AP4B1, FUCA1, ARSG, SLC11A2, CLN3, ACP2, CD164, SLC17A5, GUSB, ATP6V0A1, SORT1, SLC11A1, ATP6V1H, ATP6V0B, GALNS, TCIRG1, ATP6V0D1, AP1G1, ATP6V0C, MFSD8, GNS, NAGPA, ARSB, CTSL, CTSF, CLTCL1, HGSNAT, AP3S1, GM2A, GNPTAB, LGMN, GNPTG, ATP6V0A2, CLTB, PPT1, NAGLU, PPT2, SMPD1, HEXB, ABCA2, PLA2G15, IGF2R, CTSV, TPP1, SGSH, GBA, M6PR, HEXA",0.815308569182401,0.343901797987168,FALSE +"HCC15","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.23077,0.719,0.87,3405,1,"PLA2G1B, FGF9, FGF19, CD14, EGF, PPP5C, CHUK, FLNB, BDNF, RPS6KA5, MKNK2, CHP1, MEF2C, MAPK8, MAP3K2, MKNK1, TRAF2, ARRB1, DUSP4, MAPK14, AKT1, PLA2G4A, MAP4K3, MAP3K8, IKBKG, NR4A1, MAP2K1, CDC42, MAP3K14, MAP2K6, PRKACB, MAPK13, ATF2, TAOK2, MAPKAPK5, TNFRSF1A, MAP2K4, STK3, CDC25B, RELA, MAP3K5, PPP3R1",0.0604807473813815,0,FALSE +"HCC15","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.24869,-0.943,0.471,13942,0.983,"ONECUT1, HNF4A, HNF1A, BHLHA15, FOXA2, PDX1, GCK, HNF1B, NR5A2, HNF4G",0.326979092871104,0.00744648216786438,FALSE +"HCC15","Input","KEGG_MELANOGENESIS",0.16347,0.521,0.995,5572,1,"POMC, KIT, CALM3, ADCY9, ADCY7, CALM1, FZD3, MAP2K1, WNT3, PRKACB, CREB3L2, LEF1, HRAS, DVL1, GNAI1, GNAI3, MC1R, NRAS, CALML6, FZD9, FZD6, EDN1, CALM2, TCF7, TCF7L2, PRKCA, FZD1",0.00217691925427455,0,FALSE +"HCC15","Input","KEGG_MELANOMA",-0.24001,-0.885,0.634,16661,1,"FGF11, PIK3CA, CDKN1A, FGF2, FGF22, FGF1, PDGFRB, MAP2K2, PDGFD, FGF13, FGF12, MITF, PIK3CD, CDKN2A, AKT3, PDGFC, PIK3R2, RB1",0.197910742118267,0,FALSE +"HCC15","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.36037,1.14,0.245,3651,0.666,"ALDH3A1, CYP2S1, EPHX1, AKR1C2, AKR1C1, AKR1C3, ALDH3B1, GSTM2, GSTM4, GSTM3, CYP3A5, MGST1, CYP1B1",0.610833915635468,0.176525770829699,FALSE +"HCC15","Input","KEGG_MISMATCH_REPAIR",0.55307,1.73,0.0224,5582,0.299,"MSH2, RFC5, RFC2, MSH3, POLD3, RFC1, MSH6, RPA2, RPA1, LIG1, POLD1, EXO1, RPA3, RPA4",1.64975198166584,0.52432881167557,FALSE +"HCC15","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.29786,0.933,0.54,1866,0.927,"MLST8, PRKAA2, PDPK1, CAB39, INS, AKT1, EIF4B, ULK3, RICTOR",0.267606240177031,0.0329202658555029,FALSE +"HCC15","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.32687,1.01,0.417,4493,0.806,"RAET1G, RAET1E, SH2D1B, NFAT5, ULBP3, SYK, SHC1, IFNGR1, SHC3, CHP1, ARAF, ICAM2, NFATC3, MAP2K1, TNFRSF10A, MICB, PTK2B, MICA, KLRC3, PPP3R1, HRAS, BID, FAS, KLRC2, NRAS, PTPN6, IFNAR1, SOS1, ITGB2",0.379863945026242,0.0936649581949093,FALSE +"HCC15","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.2196,-0.823,0.686,11147,0.974,"OPRK1, GRIN2A, HTR2B, NPY2R, GABRG1, TAAR1, GRM6, MC2R, FSHR, CYSLTR2, HTR1E, CHRND, GABRA1, PRL, P2RY10, HTR4, GH1, GRM1, P2RX3, HTR1F, TSHB, ADRA1A, HCRTR2, GABRA4, NMUR1, GPR50, F2, CHRNG, RXFP1, MC5R, DRD5, MCHR1, GCGR, CHRM1, MC3R, HTR6, AVPR1A, CYSLTR1, GABRB2, GRIN3A, CALCR, GRM7, P2RX4, AVPR1B, TACR3, HRH3, ADCYAP1R1, HTR2A, GABRR2, GRIA1, CGA, NPY5R, GRM5, NMUR2, THRB, P2RY8, UTS2R, LHB, NPFFR1, CHRNB1, GRM3, NPY4R, HTR1B, GHSR, CHRNA4, PRSS2, P2RY13, GHRHR, GABRR1, GRIK3, CHRM2, F2RL3, GRIA4, CHRNA1, P2RX2, P2RX1, GABRD, PTGER3, GABRA5, PRSS1, MC4R, MCHR2, GRIA2, TACR2, CHRNA3, ADRA2C, GABRB1, P2RX6, GABRG3, TRHR, SCTR, CRHR1, CHRNB2, TSHR, PLG, GRID2, OPRD1, GRIA3, DRD1, CTSG, GRM2, GRM4, LPAR4, GRIN2C, TBXA2R, GABRA2, GABRG2, ADRA2A, GABRP, PTGIR, PTGER4, ADRA1D, NPBWR1, GRIN2B, CHRNA9, AGTR1, SSTR2, GRIN2D, CHRNB4, GRIK5, P2RY14, MLNR, MTNR1A, PTH2R, ADRA2B, GRM8, EDNRB, SSTR1, NPFFR2, NPY1R, CNR1, DRD2, PTAFR, DRD4, CHRNE, PTGER1, S1PR3, HTR2C, GALR3, GRID1, PRLR, NMBR, GABBR2, GRIK4, GPR83, GRPR, AVPR2, S1PR5, GPR35, GABRQ, PTGFR, PTGER2, PTH1R, OXTR, VIPR1, GHR, LPAR2, P2RX7, CHRM4, PRSS3, P2RY1, LPAR3, HRH4, GRIK2, BDKRB1, ADORA1, ADRA1B, BDKRB2, GABRA3, OPRL1, ADORA2A, ADORA2B, GLRB, S1PR2, GABBR1",0.163675884293248,0.0114410431213845,FALSE +"HCC15","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.23263,0.738,0.858,5017,1,"PDPK1, BDNF, RPS6KA5, SHC1, SHC3, CALM3, IRAK3, IRAK4, CALM1, MAPK8, IRAK2, ABL1, MAPK14, PRDM4, AKT1, YWHAQ, SORT1, NFKBIA, KIDINS220, MAP2K1, CDC42, YWHAG, MAPK13, IRS1, RELA, MAP3K5, HRAS, MAPK9, AKT2, RPS6KA1, NRAS, NFKBIB, SOS1, CALML6, YWHAZ, ZNF274, PIK3R1, CALM2, SOS2, RAP1B",0.0665127121512946,0,FALSE +"HCC15","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.46767,1.48,0.0538,3025,0.354,"NMNAT1, NAMPT, NNMT, NADK, NT5C2, NT5M, NT5E, NMRK1, NNT",1.26921772433361,0.450996737974212,FALSE +"HCC15","Input","KEGG_NITROGEN_METABOLISM",0.28502,0.909,0.576,1956,0.929,"CA12, CPS1, HAL, GLUD1",0.239577516576788,0.0319842860063582,FALSE +"HCC15","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.31908,1.01,0.418,5819,0.806,"CCL5, CHUK, MAPK8, MAPK14, IKBKG, NFKBIA, CASP8, MAPK13, CCL2, RELA, MAP3K7, CXCL8, HSP90AA1, MAPK9, HSP90AB1, NFKBIB, IL18, XIAP, PYCARD, NOD1, ERBIN, TAB2, TAB3, BIRC2, CARD6, TRAF6, BIRC3, SUGT1, MAPK3",0.378823718224965,0.0936649581949093,FALSE +"HCC15","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.53642,1.71,0.023,4654,0.297,"XRCC5, NHEJ1, PRKDC, XRCC4, MRE11, DCLRE1C, FEN1, RAD50",1.63827216398241,0.527243550682788,FALSE +"HCC15","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.22852,0.715,0.862,4999,1,"EGF, PDPK1, CASP9, RASSF5, E2F3, AKT1, ARAF, TGFA, MAP2K1, E2F2, HRAS, AKT2, NRAS, SOS1, CDK6, PIK3R1, RXRA, SOS2",0.0644927341752872,0,FALSE +"HCC15","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.20514,-0.78,0.784,16674,0.939,"DTX1, DLL1, DVL2, SNW1, CTBP1, DVL3, APH1A, MFNG, NOTCH4, DTX4, EP300",0.105683937315562,0.0273344077338891,FALSE +"HCC15","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.54037,1.67,0.0178,5582,0.255,"XPA, GTF2H1, ERCC3, POLE2, RFC5, POLE3, GTF2H3, RFC2, DDB2, DDB1, CUL4B, ERCC8, POLD3, RFC1, ERCC4, RPA2, RPA1, ERCC6, LIG1, POLD1, CCNH, GTF2H5, CDK7, RPA3, RPA4",1.74957999769111,0.593459819566045,FALSE +"HCC15","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.38251,1.2,0.218,5764,0.546,"ALG9, MGAT5, MGAT5B, DPAGT1, GANAB, ALG1, B4GALT1, DPM2, STT3A, ALG6, ALG13, MAN2A2, ALG8, DPM3, DOLPP1, ALG2, ALG10, TUSC3, MAN1A1, RFT1, MGAT4B, STT3B, DDOST, MGAT2",0.661543506395395,0.262807357295263,FALSE +"HCC15","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.28237,-1.08,0.346,8964,0.909,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR2AT4, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR2A42, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, ARRB2, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR51E2, OR9Q2, OR6C68, OR6C74, OR10C1, CLCA1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, CNGA3, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR5AK2, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, GUCA1C, OR2T33, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, OR56A3, OR10H2, OR10AD1, OR52B2, OR51M1, OR1B1, OR2L3, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5B21, OR5M11, OR8G5, OR13G1, GUCA1B, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR52D1, OR51I1, OR5P3, OR52N2, OR8S1, OR9A2, OR51Q1, CALML3, OR13D1, OR8D2, OR1J2, OR2S2, OR2A5, OR52H1, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, ADCY3, OR2T8, OR2C1, OR8G1, OR4F15, OR52B6, OR2A25, OR2D3, OR1Q1, OR10H1, PRKACA, OR8A1, CALML5, OR2B2, OR1K1, OR2J3, OR10A6, OR2A2, OR4F3, OR10A4, GUCY2D, OR51B4, CAMK2A, OR13A1, OR6B2, OR2A12, OR2D2, OR2AG1, OR10A3, OR2K2, OR7C1, OR13H1, OR10A2, OR2A14, OR13J1, OR4F16, CLCA2, OR2H2, OR4F17, CNGB1, OR2W3, OR6A2, OR56B4, OR5K2, OR1L8, OR2AE1, OR1J1, OR2L2, CNGA4, CAMK2B, PDE1C, PRKG1, OR2AG2, PRKG2, GRK3",0.460923901207223,0.0414361167780325,FALSE +"HCC15","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.47145,1.5,0.0579,3375,0.37,"ATIC, MTHFS, MTFMT, SHMT1, GART, DHFR",1.23732143627256,0.431798275933005,FALSE +"HCC15","Input","KEGG_OOCYTE_MEIOSIS",0.53585,1.69,0.013,5147,0.272,"PPP2R1B, PTTG1, CDC25C, SLK, CDC23, ITPR1, INS, PLK1, CALM3, CHP1, ANAPC4, PPP2R5C, BUB1, CCNB1, BTRC, ADCY9, ADCY7, CALM1, PPP2R1A, PTTG2, CCNB2, ANAPC5, PPP2R5D, SKP1, SMC3, YWHAQ, CDK1, CDC20, FBXO5, MAP2K1, SMC1A, YWHAG, PRKACB, PPP1CC, PPP2R5A, ITPR3, PPP3R1, SGO1, ANAPC7, ESPL1, REC8, RPS6KA1, CDC27, PPP1CA, CCNE2, CDK2, IGF1R, PPP1CB, CALML6, YWHAZ, CUL1, ANAPC2, PPP2CB, CALM2, FBXW11, MAD2L2, PPP3CB",1.88605664769316,0.565431095965801,FALSE +"HCC15","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.32405,1.01,0.423,2279,0.806,"FUCA1, FUCA2, MAN2C1",0.373659632624958,0.0936649581949093,FALSE +"HCC15","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.24662,0.779,0.778,4667,1,"NDUFS3, ATP6V0A4, ATP5F1B, ATP6V0E1, ATP6V1E1, ATP6V1C1, ATP6V0A1, ATP6V1H, NDUFA9, ATP6V0B, ATP5MG, TCIRG1, ATP6V0D1, NDUFV3, PPA1, ATP6V0C, COX5A, NDUFB10, ATP5PO, COX15, NDUFA2, ATP6V1A, COX7A2, NDUFB1, ATP6V0E2, ATP5F1C, NDUFS1, NDUFAB1, ATP5MC3, ATP5F1D, COX8A, ATP6V1G1, ATP6V0A2, ATP5MC2, CYC1, COX4I1, SDHD",0.109020403010311,0,FALSE +"HCC15","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.30754,-1.18,0.189,14442,0.924,"GALNT3, GALNTL6, ST6GALNAC1, GALNT15, GALNT9, GALNT13, GCNT4, GCNT1, GALNT16, GALNT14, ST3GAL1, GALNT18, GALNT7",0.723538195826756,0.0343280287798933,FALSE +"HCC15","Input","KEGG_P53_SIGNALING_PATHWAY",0.30407,0.947,0.501,4224,0.898,"CCND3, CASP9, APAF1, CCNB1, CCNB2, PMAIP1, CHEK1, EI24, ATM, CDK1, DDB2, CASP8, RRM2, SERPINB5, PIDD1, CCNG1, BID, SFN, COP1, FAS, CCNE2, CDK2",0.300162274132754,0.0467236633326956,FALSE +"HCC15","Input","KEGG_PANCREATIC_CANCER",0.28222,0.884,0.604,4555,0.973,"EGF, CHUK, CASP9, SMAD2, MAPK8, E2F3, AKT1, ARAF, TGFA, RAD51, BCL2L1, IKBKG, MAP2K1, CDC42, E2F2, RELA, MAPK9, AKT2, RALB, TGFB1, TGFBR2, CDK6",0.218963061378868,0.0118871597316481,FALSE +"HCC15","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.24745,0.793,0.778,2722,1,"BCAT1, PPCDC, COASY",0.109020403010311,0,FALSE +"HCC15","Input","KEGG_PARKINSONS_DISEASE",0.21586,0.682,0.896,4757,1,"NDUFS3, CASP9, VDAC2, APAF1, SLC18A2, ATP5F1B, PARK7, UCHL1, NDUFA9, UBE2J1, NDUFV3, COX5A, NDUFB10, UBE2G2, ATP5PO, NDUFA2, VDAC1, COX7A2, NDUFB1, ATP5F1C, NDUFS1, NDUFAB1, UBA1, ATP5MC3, ATP5F1D, COX8A, ATP5MC2, CYC1, COX4I1, SDHD, UBE2J2",0.0476919903378748,0,FALSE +"HCC15","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.43743,1.4,0.0894,5551,0.375,"TUBAL3, CD14, ROCK2, ARPC2, WASL, ARPC5L, KRT18, ABL1, YWHAQ, LY96, ARPC3, CDC42, NCL, TUBB3, ARPC4, ARPC1A, TUBB2A, YWHAZ, ITGB1, TUBA1C, TUBB, TUBA4A, CTTN, TUBA1B, EZR, PRKCA, CDH1",1.04866248120408,0.425968732272281,FALSE +"HCC15","Input","KEGG_PATHWAYS_IN_CANCER",0.2259,0.712,0.883,5626,0.998,"FGF9, COL4A6, FGF19, CSF2RA, EGF, KIT, CHUK, CASP9, EGLN1, RASSF5, SMAD2, SLC2A1, AXIN2, BMP4, PPARD, MAPK8, TRAF2, MSH2, TPR, E2F3, ABL1, CKS1B, AKT1, CTNNA1, ARAF, TGFA, CUL2, FZD3, RAD51, NCOA4, HDAC1, BCL2L1, GLI2, EGLN3, CTBP2, IKBKG, APC, NFKBIA, MAP2K1, CBL, CDC42, CASP8, WNT3, MSH3, E2F2, MSH6, PIAS1, COL4A4, PTGS2, MTOR, RELA, SUFU, APPL1, LEF1, JUP, ITGA2, HRAS, DVL1, LAMB3, CXCL8, BID, HSP90AA1, MAPK9, AKT2, RALB, FAS, HSP90AB1, CCNE2, NRAS, CDK2, TGFB1, PML, IGF1R, TGFBR2, ELOC, SOS1, XIAP, CDK6, TPM3, ITGA6, ITGB1, FZD9, VHL, FGF3, FZD6, PIK3R1, CCDC6, RXRA, SOS2, BIRC5, ELOB, TCF7, PTEN, BIRC2, LAMA1, TCF7L2, TRAF6, TRAF3, PRKCA, CDH1, FZD1, HDAC2, CRK, BIRC3, CDKN1B, LAMB2",0.0540392964224314,0.000869458712628891,FALSE +"HCC15","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.48286,1.52,0.044,3070,0.353,"UGDH, RPEL1, GUSB, DCXR, RPE",1.35654732351381,0.452225294612177,FALSE +"HCC15","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.53817,1.69,0.0211,3070,0.272,"PGD, TALDO1, G6PD, PFKP, RBKS, RPEL1, H6PD, GPI, TKT, ALDOA, RPE",1.67571754470231,0.565431095965801,FALSE +"HCC15","Input","KEGG_PEROXISOME",0.28942,0.91,0.589,6744,0.936,"PRDX1, SCP2, SLC27A2, MPV17L, NUDT19, SOD1, DECR2, ABCD1, ACOX1, GNPAT, PEX6, PEX1, DHRS4, PECR, MPV17, PEX13, PEX14, PEX7, CRAT, GSTK1, FAR1, CROT, PEX16, PHYH, EPHX2, PEX3, ABCD3, ACSL3, SOD2, PEX11B, IDH1, PMVK, AGPS, ECI2, ACSL1",0.229884705212898,0.0287241512618947,FALSE +"HCC15","Input","KEGG_PHENYLALANINE_METABOLISM",0.45266,1.41,0.085,3387,0.382,"ALDH3A1, PAH, PRDX6, ALDH3B1, GOT2, MAOA",1.07058107428571,0.417936637088291,FALSE +"HCC15","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.22546,0.704,0.873,5224,0.992,"ITPR1, SYNJ1, CALM3, DGKG, CALM1, IPPK, PLCD4, IMPA1, PIKFYVE, DGKD, PIK3C2A, INPP5A, ITPK1, ITPR3, ITPKA, ITPKB, PLCD3, IMPA2, CALML6, PIK3R1, CALM2, DGKA, CDIPT, INPP1, PTEN",0.0589857562944303,0.00348832784582135,FALSE +"HCC15","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.39101,1.23,0.167,1990,0.518,"HMBS, EARS2, BLVRA, UROS, GUSB, BLVRB",0.777283528852417,0.285670240254767,FALSE +"HCC15","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.2493,0.794,0.776,1391,1,"SCP2, SLC27A2, PDPK1, ME1, PPARD, PPARA, CYP27A1",0.110138278741812,0,FALSE +"HCC15","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.64526,2.01,0.00352,1700,0.212,"CYP39A1, SCP2, CYP27A1, HSD3B7",2.45345733652187,0.673664139071249,TRUE +"HCC15","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.25478,-0.945,0.525,11935,1,"CD79A, CD8B, TAP2, AICDA, AIRE, RFXAP, BTK, CD3D, IL2RG, CIITA, IGLL1, LCK, RAG1, BLNK, CD8A, JAK3, RFX5, IL7R, RFXANK",0.279840696594043,0,FALSE +"HCC15","Input","KEGG_PRION_DISEASES",0.24516,0.771,0.781,3165,1,"CCL5, STIP1, SOD1, MAP2K1, PRKACB, C5",0.1073489661227,0,FALSE +"HCC15","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.42902,1.35,0.111,4818,0.363,"PDE3A, CDC25C, CDC23, INS, PLK1, ANAPC4, BUB1, CCNB1, ADCY9, ADCY7, MAPK8, CCNB2, ANAPC5, MAPK14, AKT1, ARAF, CDK1, MAP2K1, PRKACB, MAPK13, CDC25B, ANAPC7, GNAI1, HSP90AA1, MAPK9, AKT2, RPS6KA1, CDC27, GNAI3, HSP90AB1, CDK2, IGF1R, CCNA2, PIK3R1, ANAPC2",0.954677021213343,0.440093374963888,FALSE +"HCC15","Input","KEGG_PROPANOATE_METABOLISM",0.32908,1.05,0.372,5284,0.76,"HADHA, ALDH9A1, LDHA, HIBCH, MCEE, ALDH3A2, ACAT1, ALDH2, ACACA, ECHS1, ACSS2, LDHAL6B, ALDH7A1, ACACB, LDHB",0.429457060118102,0.119186407719209,FALSE +"HCC15","Input","KEGG_PROSTATE_CANCER",0.23815,0.752,0.821,4450,1,"EGF, CHUK, PDPK1, INS, CASP9, E2F3, AKT1, ARAF, TGFA, IKBKG, NFKBIA, MAP2K1, CREB3L2, E2F2, MTOR, RELA, LEF1, HRAS, HSP90AA1, AKT2, HSP90AB1, CCNE2, NRAS, CDK2, IGF1R, SOS1",0.0856568428805592,0,FALSE +"HCC15","Input","KEGG_PROTEASOME",0.48553,1.52,0.0441,4892,0.353,"PSMC6, PSMA6, PSMA1, PSMC1, PSMA4, PSMC3, PSMB1, PSMA5, PSMB2, PSME2, PSMD1, PSMD14, PSMD8, PSMD13, PSMC2, PSMD4, PSMB7, PSME1, PSMD12, PSME4, PSMA2, PSMD7",1.35556141053216,0.452225294612177,FALSE +"HCC15","Input","KEGG_PROTEIN_EXPORT",0.4637,1.48,0.0583,5209,0.354,"SRP54, SEC11A, SEC63, SRP9, SRPRA, SRP72, SRP19, SRP68, SEC61A2, SRP14, SPCS2, SEC61B",1.23433144524099,0.450996737974212,FALSE +"HCC15","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.20006,-0.75,0.803,11762,0.912,"ATP1B4, ATP1A4, SLC9A3, ATP1B3, PCK1, GLS, GLS2, ATP1B2, PCK2, ATP1A2, FXYD2, SLC4A4, AQP1, ATP1A3, CA2",0.095284454721319,0.0400051616715838,FALSE +"HCC15","Input","KEGG_PURINE_METABOLISM",0.39136,1.22,0.196,4668,0.53,"PDE7B, PDE8B, PDE4D, PDE3A, PDE8A, PDE10A, ADCY10, PDE4B, POLR2J2, PDE2A, ENTPD8, RRM1, ADCY9, ADCY7, POLE2, POLE3, ATIC, ADK, POLR2E, PDE9A, POLA1, PRIM1, POLR3K, POLR2D, NT5C2, POLR2A, NT5M, POLR1A, NT5E, NUDT5, RRM2, POLA2, PRIM2, POLR2C, POLD3, POLR3A, PKM, POLR2L, GART, NME3, PDE6D, PDE7A, AMPD3, POLR2G, AK2, NT5C3A, POLR3B, POLR1C, POLR1B, POLD1, GMPR2, APRT, GUK1, PRPS1, ADA",0.707743928643524,0.275724130399211,FALSE +"HCC15","Input","KEGG_PYRIMIDINE_METABOLISM",0.38203,1.21,0.205,4243,0.534,"POLR2J2, CTPS1, ENTPD8, TXNRD1, DTYMK, RRM1, POLE2, POLE3, CMPK1, DHODH, POLR2E, POLA1, CDA, PRIM1, POLR3K, POLR2D, NT5C2, DUT, POLR2A, NT5M, POLR1A, NT5E, RRM2, POLA2, PRIM2, POLR2C, POLD3, POLR3A, POLR2L, CAD, NME3, POLR2G, UCK2, NT5C3A, POLR3B, POLR1C, POLR1B, POLD1",0.688246138944246,0.272458742971444,FALSE +"HCC15","Input","KEGG_PYRUVATE_METABOLISM",0.38381,1.21,0.18,5284,0.534,"PC, ME1, DLAT, ME3, ALDH9A1, LDHA, ALDH3A2, ACAT1, GLO1, PKM, ALDH2, ACACA, DLD, ACSS2, LDHAL6B, ALDH7A1, ACACB, LDHB",0.744727494896694,0.272458742971444,FALSE +"HCC15","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.27296,0.876,0.641,5845,0.963,"FGF9, FGF19, CD14, ITGA10, EGF, CFL2, INS, ROCK2, ITGA1, GNA13, IQGAP2, IQGAP1, ARPC2, DIAPH1, WASL, ARPC5L, ARHGEF4, MYLK2, ARAF, ITGB5, NCKAP1, WASF2, APC, ARPC3, MAP2K1, ARHGEF12, PIKFYVE, BRK1, CDC42, ARHGAP35, ITGB7, PPP1CC, CYFIP1, CFL1, ITGB4, IQGAP3, ACTN4, FGD1, ITGA2, HRAS, PXN, MSN, LIMK1, PPP1CA, ARHGEF1, NRAS, ARPC4, PPP1CB, SSH1, SOS1, ARPC1A, ITGB2, ITGA6, ITGB1, MYH10, RDX, FGF3, PIK3R1, DIAPH2, SOS2, F2R, RRAS2, EZR, PAK1, ITGA11, PFN4, RRAS, CRK, VCL, BCAR1, ITGAE, MAPK3, MYLPF, PIP4K2C",0.193141970481183,0.0163737128754655,FALSE +"HCC15","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.25687,0.806,0.749,4928,1,"PRKAA2, INS, ULK3, ATG4A, ATG12, GABARAPL2, ATG4C, ULK2, ATG5, PRKAA1",0.125518182300534,0,FALSE +"HCC15","Input","KEGG_RENAL_CELL_CARCINOMA",-0.21133,-0.802,0.744,17066,0.956,"RBX1, FLCN, MAP2K2, VEGFB, ARNT2, PGF, PIK3CD, AKT3, EP300, PIK3R2, JUN, GAB1",0.128427064454121,0.0195421077238999,FALSE +"HCC15","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.34697,-1.28,0.14,13968,1,"CMA1, AGT, CTSG, AGTR1, ACE, ENPEP, MME, ANPEP, CTSA",0.853871964321762,0,FALSE +"HCC15","Input","KEGG_RETINOL_METABOLISM",-0.28828,-1.09,0.358,10894,1,"UGT2B11, CYP4A11, CYP2A13, ADH1B, RDH8, ADH7, ADH4, UGT2B17, CYP1A2, ADH1A, AWAT2, CYP3A43, UGT2A1, UGT2A3, UGT2B15, CYP2A7, DGAT2, RPE65, CYP2C18, CYP2B6, CYP2C9, CYP4A22, ADH1C, CYP2A6, CYP2C8, DHRS3, RDH16, CYP26A1, BCO1, CYP3A4, ADH6, DHRS9, UGT2B7, ADH5, LRAT, RDH12, CYP26B1, RDH10, ALDH1A2, RDH11",0.446116973356126,0,FALSE +"HCC15","Input","KEGG_RIBOFLAVIN_METABOLISM",0.41116,1.29,0.139,6028,0.432,"RFK, ACP2, MTMR2, ACP1, FLAD1, MTMR7, MTMR6, PHPT1",0.856985199745905,0.364516253185088,FALSE +"HCC15","Input","KEGG_RIBOSOME",-0.45847,-1.81,0,16686,0.754,"RPL27, RPL17, RPL19, RPL28, RPL36A, RPS3A, RPL29, RPLP2, RPL24, RPS6, RPL32, RPL23, RPL21, UBA52, RPL23A, RPSA, RPL37, RPL3, RPL15, RPL18A, RPS28, RPL22L1, RPS19, RPL35A, RPL38, RPL36, RPS21",Inf,0.122628654130226,FALSE +"HCC15","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.41719,1.32,0.117,3809,0.387,"CHUK, TBK1, MAPK8, TRAF2, DDX3X, MAPK14, NLRX1, IKBKG, NFKBIA, TANK, CASP8, CASP10, MAPK13, ISG15, CYLD, IFIH1, ATG12, RELA, TKFC, RIPK1, MAP3K7, CXCL8, MAPK9",0.931814138253838,0.412289034981089,FALSE +"HCC15","Input","KEGG_RNA_DEGRADATION",0.43595,1.37,0.0925,4776,0.348,"ENO3, CNOT8, CNOT9, EXOSC10, ENO1, TTC37, WDR61, PAPOLA, DDX6, HSPD1, EXOSC2, DCPS, LSM2, HSPA9, CNOT1, PARN, EDC4, EXOSC6, CNOT4, MTREX, LSM8, CNOT6, DCP2, C1D, PATL1, PAPOLG, LSM5, SKIV2L",1.03385826726097,0.458420756053419,FALSE +"HCC15","Input","KEGG_RNA_POLYMERASE",0.42722,1.36,0.107,4194,0.355,"POLR2J2, POLR2E, POLR3K, POLR2D, POLR2A, POLR1A, POLR2C, POLR3A, POLR2L, POLR2G, POLR3B, POLR1C, POLR1B",0.97061622231479,0.449771646944906,FALSE +"HCC15","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.47285,1.47,0.0569,5704,0.343,"TRMT11, GGT5, MAT2A, MAT2B, GGT1, SEPHS1, AHCYL2, AHCYL1, METTL2B, BUD23, LCMT2, LCMT1, CTH, SEPHS2",1.24488773360493,0.464705879957229,FALSE +"HCC15","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.27675,0.86,0.656,5626,0.973,"COL4A6, CHUK, CASP9, APAF1, TRAF2, E2F3, CKS1B, AKT1, BCL2L1, IKBKG, NFKBIA, E2F2, PIAS1, COL4A4, PTGS2, RELA, ITGA2, LAMB3, AKT2, CCNE2, CDK2, XIAP, CDK6, ITGA6, ITGB1, PIK3R1, RXRA, PTEN, BIRC2, LAMA1, TRAF6, TRAF3, BIRC3, CDKN1B, LAMB2",0.18309616062434,0.0118871597316481,FALSE +"HCC15","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.25956,0.817,0.74,4869,1,"VAMP1, GOSR1, VTI1A, STX12, VAMP8, VAMP2, VAMP7, VAMP3, STX17, BNIP1, STX7, STX1A, STX4",0.130768280269024,0,FALSE +"HCC15","Input","KEGG_SPHINGOLIPID_METABOLISM",0.36999,1.17,0.223,4954,0.609,"GLA, SGMS1, ACER3, SPTLC1, PLPP3, SMPD4, ASAH2, SGPL1, CERK, DEGS1, SMPD1, SMPD3",0.651695136951839,0.215382707367125,FALSE +"HCC15","Input","KEGG_SPLICEOSOME",0.31462,1,0.449,5523,0.824,"SRSF10, DHX15, PRPF4, SNRNP200, PPIL1, RBM22, DDX5, RBM17, AQR, SNRPA1, DDX23, TCERG1, CDC40, THOC2, SF3B1, SMNDC1, PRPF40A, SNRPC, SRSF4, LSM2, SF3B3, SF3B5, THOC3, PPIE, MAGOHB, PRPF38A, PRPF3, PRPF18, SNRNP40, ACIN1, PRPF8, SLU7, NCBP1, CDC5L, PQBP1, LSM8, SF3B2, DDX46, U2AF1, PCBP1, HNRNPK, SNRNP27, HNRNPU, WBP11, USP39, PRPF19, U2AF2, HSPA2, LSM5, BCAS2, DHX38, SF3A3, DDX39B, BUD31, DHX16, HSPA1A, HSPA8, TRA2A, PRPF31, SRSF1, SRSF8, SNRPA",0.347753658996677,0.0840727883028842,FALSE +"HCC15","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.30853,0.974,0.471,5410,0.845,"UGDH, PGM2L1, AGL, GUSB, G6PC2, GPI, HK3, GBE1, HK1, PGM2, UXS1, PGM1",0.326979092871104,0.0731432910503077,FALSE +"HCC15","Input","KEGG_STEROID_BIOSYNTHESIS",-0.39613,-1.49,0.0647,16101,0.877,"CEL, SQLE, DHCR7, DHCR24, FDFT1, MSMO1",1.1890957193313,0.0570004066339595,FALSE +"HCC15","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.24083,0.758,0.833,925,1,"AKR1C2, AKR1C1, AKR1C3",0.0793549985932124,0,FALSE +"HCC15","Input","KEGG_SULFUR_METABOLISM",0.52829,1.67,0.0294,6347,0.255,"SULT1A4, BPNT1, SULT1A1, SULT1A2, SULT1A3, SUOX, SULT2B1, PAPSS2",1.53165266958784,0.593459819566045,FALSE +"HCC15","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.32317,-1.2,0.222,13383,0.973,"C8G, FCGR2C, C7, C4A, C3, CD86, CTSG, ELANE, GRIN2B, TNF, ACTN2, FCGR2A, FCGR1A, SNRPB, C2, C1S, C1R, ACTN1, SNRPD3, SNRPD1",0.653647025549361,0.0118871597316481,FALSE +"HCC15","Input","KEGG_TASTE_TRANSDUCTION",0.23334,0.73,0.859,5286,1,"TAS2R20, TAS2R10, TAS1R3, TAS2R4, PRKACB, ITPR3, GNB1, TAS2R14, TAS2R5, TAS2R9, TAS2R13, TAS2R46, SCNN1A",0.0660068361687577,0,FALSE +"HCC15","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.51342,1.6,0.0243,2030,0.298,"GGT5, GGT1, CSAD",1.61439372640169,0.525783735923745,FALSE +"HCC15","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.23986,0.756,0.819,3708,1,"PDSS2, ACAT1, IDI1",0.0867160982395816,0,FALSE +"HCC15","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.23666,0.741,0.855,5880,1,"PPP2R1B, ROCK2, SMAD2, BMP4, PPP2R1A, ZFYVE16, SKP1, BMPR1A, SMURF2, ID1, SP1, SMAD5, ID3, ZFYVE9, E2F4, ID2, TGFB1, TGFBR2, ACVR2A, SMAD6, BMPR2, CUL1, BMP8B, RBL1, PPP2CB, BMP6, SMAD7, BMP8A, MAPK3, TGFB2, ID4",0.0680338852718274,0,FALSE +"HCC15","Input","KEGG_THYROID_CANCER",0.32015,1.02,0.397,6141,0.81,"TPR, NCOA4, MAP2K1, LEF1, HRAS, NRAS, TPM3, CCDC6, RXRA, TCF7, TCF7L2, CDH1, MAPK3, TP53",0.401209493236885,0.0915149811213502,FALSE +"HCC15","Input","KEGG_TIGHT_JUNCTION",0.2146,0.67,0.935,6527,1,"PPP2R1B, CLDN2, MAGI3, PPP2R1A, TJP1, PRKCQ, AKT1, CTNNA1, PPP2R2C, EPB41, PPP2R2A, PRKCE, CDC42, SPTAN1, TJP2, PRKCH, PPP2R2D, CLDN4, ACTN4, HRAS, GNAI1, CLDN23, AKT2, GNAI3, CSNK2B, NRAS, ASH1L, LLGL2, VAPA, MYH10, TJP3, CLDN3, CLDN20, PPP2CB, SYMPK, CTTN, PTEN, RRAS2, PRKCA, PPP2R2B, RRAS, TJAP1, MYLPF, MAGI2, MYH7B, SRC, CSNK2A2, PARD6A, RHOA, MYL12A, PARD3, CLDN7",0.0291883891274822,0,FALSE +"HCC15","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.31149,0.975,0.482,3845,0.852,"TLR6, CD14, CCL5, CHUK, TIRAP, TLR1, TBK1, IRAK4, MAPK8, MAPK14, AKT1, LY96, MAP3K8, IKBKG, NFKBIA, MAP2K1, CASP8, MAP2K6, MAPK13, MAP2K4, RELA, RIPK1, MAP3K7, CXCL8, MAPK9, AKT2",0.31695296176115,0.0695604052332999,FALSE +"HCC15","Input","KEGG_TRYPTOPHAN_METABOLISM",0.28015,0.883,0.628,3959,0.966,"HADHA, KYNU, ALDH9A1, ALDH3A2, ACAT1, ALDH2, MAOA, CYP1B1, ECHS1",0.202040356262804,0.0150228735845067,FALSE +"HCC15","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.27663,-1.02,0.389,14877,0.969,"TNF, SOCS2, PDX1, PRKCZ, GCK, SLC2A4, CACNA1C, CACNA1A, PIK3CA, CACNA1D, KCNJ11, MAPK10, SOCS1, PIK3CD, INSR, PRKCD, PIK3R2, HK2",0.410050398674292,0.0136762229492347,FALSE +"HCC15","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.2628,0.827,0.727,4202,1,"INS, HSPD1, FAS, GAD1, PTPRN2",0.138465589140962,0,FALSE +"HCC15","Input","KEGG_TYROSINE_METABOLISM",0.21434,0.674,0.92,3908,1,"ALDH3A1, TRMT11, FAH, ALDH3B1, METTL2B, GOT2, MAOA, BUD23",0.0362121726544447,0,FALSE +"HCC15","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.2321,0.739,0.85,4450,1,"TEC, NFAT5, CHUK, PDPK1, CHP1, PRKCQ, MAPK14, AKT1, MAP3K8, NFATC3, IKBKG, NFKBIA, MAP2K1, CBL, CDC42, MAP3K14, MAPK13, RELA, PPP3R1, HRAS, MAP3K7, MAPK9, AKT2, NRAS, PTPN6, NFKBIB, SOS1",0.0705810742857073,0,FALSE +"HCC15","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.43459,1.37,0.0917,4818,0.348,"UBE2B, SAE1, SYVN1, CDC23, ANAPC4, BTRC, UBE2S, MID1, FANCL, UBE4A, CUL3, ANAPC5, SKP1, BIRC6, SMURF2, UBA2, WWP2, CUL2, CUL5, HERC2, CDC20, NEDD4, UBE2J1, UBE2A, DDB2, CBL, DDB1, CDC34, RHOBTB2, TRIP12, CUL4B, ERCC8, KEAP1, UBE2Q2, PIAS1, UBE3C, UBE2D4, UBE2G2, UBE2I, WWP1, HUWE1, ANAPC7, UBE2K, UBA1, UBE4B, HERC1, COP1, CDC27, UBE3A, HERC4, STUB1, UBE3B, PML, UBE2M, ELOC, BRCA1, PRPF19, XIAP, NHLRC1, UBE2D2, CUL1, UBE2H, VHL, UBE2J2, ANAPC2",1.03763066432998,0.458420756053419,FALSE +"HCC15","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.55596,1.73,0.015,1835,0.299,"IARS2, BCAT1",1.82390874094432,0.52432881167557,FALSE +"HCC15","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.30615,0.966,0.493,3959,0.857,"HADHA, HADHB, ACADSB, AUH, ALDH9A1, HIBCH, BCAT1, MCEE, ALDH3A2, ACAT1, ALDH2, MCCC2, ACADS, DLD, ECHS1",0.30715308072277,0.0670191780768018,FALSE +"HCC15","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.35015,1.12,0.275,2665,0.675,"PLA2G1B, ITPR1, ROCK2, GNA13, CALM3, RAMP1, ADCY9, ADCY7, CALM1, PRKCQ, MYLK2, PPP1R14A, ARAF, PLA2G4A, PRKCE, MAP2K1, ARHGEF12, PRKACB, PPP1CC",0.560667306169737,0.170696227168975,FALSE +"HCC15","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.30806,0.983,0.467,2913,0.84,"DYNC1LI2, ADCY9, DYNC1H1, RAB11A, DCTN4, PRKACB, DCTN5, CREB3L2, VAMP2",0.330683119433888,0.0757207139381184,FALSE +"HCC15","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.35817,1.14,0.261,3845,0.666,"PLA2G1B, NFAT5, CASP9, CHP1, MAPK14, AKT1, PLA2G4A, NFATC3, MAP2K1, CDC42, MAPK13, PTGS2, PPP3R1, HRAS, PXN, AKT2",0.583359492661719,0.176525770829699,FALSE +"HCC15","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.43439,1.37,0.0896,4465,0.348,"ATP6V0A4, SLC12A2, ERO1A, KDELR1, ADCY9, TJP1, ATP6V0E1, ATP6V1E1, ATP6V1C1, ATP6V0A1, ATP6V1H, ATP6V0B, TCIRG1, ATP6V0D1, ATP6V0C, PRKACB, TJP2, ATP6V1A, ATP6V0E2, ATP6V1G1, ARF1, ATP6V0A2, SEC61A2",1.04769199033787,0.458420756053419,FALSE +"HCC15","Input","KEGG_VIRAL_MYOCARDITIS",0.18245,0.57,0.979,5510,1,"CASP9, ABL1, CXADR, CASP8, EIF4G3, EIF4G2, BID, ITGB2, CD55, MYH10, CD40, ICAM1",0.00921730819686218,0,FALSE +"HCC15","Input","KEGG_WNT_SIGNALING_PATHWAY",0.31282,0.985,0.448,2177,0.845,"WIF1, PPP2R1B, NKD1, CCND3, NFAT5, NKD2, ROCK2, CHP1, VANGL1, SMAD2, PPP2R5C, TBL1X, AXIN2, BTRC, CSNK1E, PPARD, PPP2R1A, MAPK8, PPP2R5D, CACYBP, SKP1, FZD3, LRP5, NFATC3, CTBP2, 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+
+
+ + + + diff --git a/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_mean_results.csv b/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..4ddc1a8 --- /dev/null +++ b/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"PPAR receptor agonist",0.760733333333333,1.23032280704042,0.000167330222373428,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H2009, H2126, A549",0.000992029175499609 +"BCL inhibitor",0.635533333333333,0.752433657888727,0.836561136257018,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"estrogen receptor antagonist",0.6348,0.7965995767726,0.619806679699137,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.843343515000466 +"glutamate receptor antagonist",0.5856,0.638297042360149,0.984847949720954,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"bromodomain inhibitor",0.552333333333333,1.53481793553441,1.67475661741983e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,7,"H1650, H1975, H2126, H3255, A549, HCC15, H520",4.63349330819487e-06 +"NFkB pathway inhibitor",0.551266666666667,0.897440763398634,0.574122739243052,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.843343515000466 +"progesterone receptor agonist",0.452733333333333,1.12256469534637,0.0792067067259401,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.156527539482215 +"RAF inhibitor",0.436466666666667,1.45366963562008,8.20395628825395e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, H2009, H3255, H358",0.000619025792659162 +"MEK inhibitor",0.3912,1.29333330142366,0.0059568926836002,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H2126, A549, H1299, H1703",0.0164807364246272 +"calcium channel blocker",0.324666666666667,0.894768658582179,0.936575671507874,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"AP inhibitor",0.305666666666667,1.14347419651483,0.179090655280002,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, H1299",0.323141834526961 +"HCV inhibitor",0.291133333333333,1.16472607856751,0.125385739920975,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.236523100305476 +"dopamine receptor antagonist",0.2814,1.08058831859581,0.296291719929497,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.496090517959968 +"sodium channel blocker",0.2742,0.998864226437779,0.688490569239473,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.892886206982442 +"glucocorticoid receptor agonist",0.2734,1.00843271607834,0.686856431286151,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.892886206982442 +"glycogen synthase kinase inhibitor",0.2528,0.929019006417907,0.924657451668142,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"DNA inhibitor",0.230533333333333,1.03882583901707,0.60109875844015,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.843343515000466 +"MDM inhibitor",0.219,1.52620547203093,0.00173738654258836,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"HCC95, H1975, H2009, H2126, H358",0.00721015415174168 +"acetylcholine receptor agonist",0.215,1.04121165681417,0.611873052665853,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.843343515000466 +"acetylcholine receptor antagonist",0.212466666666667,1.55783127028143,6.62298560136289e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1650, H1975, H2009, H3255, H520",0.000587172288938228 +"CC chemokine receptor antagonist",0.193866666666667,1.04814024870357,0.55328735014189,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.834960910214125 +"phosphatase inhibitor",0.179266666666667,1.23307521880788,0.0535737707699486,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.111165574347643 +"adenosine receptor antagonist",0.1662,1.44916508967849,0.0019634659533549,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H2126, A549, HCC44, H1299",0.00776036543468841 +"TGF beta receptor inhibitor",0.164666666666667,1.47375345227594,0.00124386255483483,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"A549, HCC44, H1299, H520",0.00543371537112055 +"AKT inhibitor",0.135733333333333,1.39017144197946,0.00279190287394992,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"A549, H1299",0.00965533077241016 +"ribonucleotide reductase inhibitor",0.1266,1.42980846869182,0.000192611444883826,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H2126",0.00106578332835717 +"cytochrome P450 inhibitor",0.0991999999999999,1.65722863324803,0.000210499844621686,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1975, H2009, H3255, H460, H520",0.001091967943975 +"FGFR inhibitor",0.0948666666666667,1.25242809127292,0.0316161189959459,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0690562599121975 +"serotonin receptor antagonist",0.0828,1.19390052229776,0.0976336162332552,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.18845558482233 +"benzodiazepine receptor agonist",0.0255333333333334,0.769114041949443,0.99985851150393,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"ATPase inhibitor",0.0237333333333334,1.39353530206279,0.000122762043908677,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1650, A549, H1299",0.000783788434186171 +"proteasome inhibitor",0.0144,1.05288825889279,0.616305582678248,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.843343515000466 +"FLT3 inhibitor",0.00433333333333337,1.06886693456647,0.532191529275925,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.817998091294478 +"HDAC inhibitor",-0.0038,1.27422380855394,0.00487149818162925,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, HCC15",0.0144405124669724 +"PARP inhibitor",-0.0094666666666666,1.28083231124289,0.00770212473874496,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H2126",0.0206218178488978 +"thymidylate synthase inhibitor",-0.0208666666666668,1.09927104851135,0.360719516250298,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.575763843245669 +"DNA alkylating agent",-0.0276666666666666,1.13523513402458,0.308551743330339,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.50215283718467 +"HMGCR inhibitor",-0.038,2.06637086976868,2.81192824270463e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,13,"HCC827, HCC95, H1975, H2009, H2126, H3255, H358, A549, HCC44, H1299, H1703, H460, H520",5.83475110361212e-06 +"opioid receptor agonist",-0.0645333333333334,1.13473576953697,0.260174734379682,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.4498854781982 +"CHK inhibitor",-0.0728,1.07417358267381,0.598640858831536,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.843343515000466 +"PI3K inhibitor",-0.0841333333333333,0.943188200176604,0.918379844835189,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"p38 MAPK inhibitor",-0.0984,1.40553760939669,0.0026088777916596,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC827, H3255, H1299",0.00941464594381506 +"retinoid receptor agonist",-0.0984,1.33723412844786,0.00335406356611246,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.0111354910394934 +"DNA polymerase inhibitor",-0.107733333333333,1.06385535178604,0.4938917724513,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.773453153084112 +"bacterial DNA gyrase inhibitor",-0.120266666666667,0.892620017273921,0.977915690015317,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"vitamin D receptor agonist",-0.137866666666667,1.98002257803385,2.37713878693295e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,11,"HCC827, H1650, H1975, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460",3.9460503863087e-05 +"serotonin receptor agonist",-0.146,1.48735527507241,1.32871492582267e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1975, A549, H1299",0.000183805564738803 +"DNA synthesis inhibitor",-0.1472,1.11410266262008,0.298849709614438,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.496090517959968 +"adrenergic receptor antagonist",-0.1498,0.697358198591554,0.999999633811902,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"mTOR inhibitor",-0.151933333333333,1.00343029273635,0.727742360780241,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.92927101453477 +"DNA methyltransferase inhibitor",-0.169733333333333,1.26712393500662,0.0261159889968523,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.0585845158578038 +"androgen receptor antagonist",-0.178866666666667,1.52011225462683,0.0022259745008619,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1650, HCC15, H520",0.00839799470779716 +"phosphodiesterase inhibitor",-0.1834,1.01448050041107,0.687697031419794,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.892886206982442 +"PDGFR tyrosine kinase receptor inhibitor",-0.191133333333333,0.986673622884101,0.80759389131879,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"estrogen receptor agonist",-0.199,0.848302675093877,0.98788418925686,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"protein tyrosine kinase inhibitor",-0.199466666666667,1.6350492725938,1.89078965213184e-09,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,9,"HCC827, HCC95, H1975, H2009, H3255, H358, A549, H1299, H1703",7.84677705634712e-08 +"antioxidant",-0.220733333333333,1.37947000519696,0.00113092001697756,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1975, HCC15",0.00521479785606321 +"CDK inhibitor",-0.237933333333333,0.895274137319056,0.94493251729883,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"protein synthesis inhibitor",-0.238466666666667,1.2845231392381,0.00469548729435226,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H460, H520",0.0144342757567125 +"KIT inhibitor",-0.2428,0.910896983355261,0.91935815178424,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"Aurora kinase inhibitor",-0.2624,1.2426476227337,0.0125481218134206,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0306321797209974 +"VEGFR inhibitor",-0.263266666666667,0.883200225370917,0.967312380279596,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"tyrosine kinase inhibitor",-0.264933333333333,1.21988919090844,0.0740706728392538,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.149947947455075 +"histamine receptor antagonist",-0.2666,0.82455241538321,0.993197023505866,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"growth factor receptor inhibitor",-0.272,1.25695169812868,0.0144970697625136,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0343787654368179 +"potassium channel blocker",-0.2886,1.25660186898749,0.00961603897481951,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1975, HCC44",0.0249416010909381 +"adrenergic receptor agonist",-0.328666666666667,0.786901216042728,0.994281906885891,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"microtubule inhibitor",-0.350066666666667,1.27105785339089,0.00367780830499553,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0117406957428703 +"JAK inhibitor",-0.353133333333333,0.962050478826098,0.74287148996616,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.934217176775626 +"EGFR inhibitor",-0.3608,1.91312799960095,0.0186105572783557,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,10,"HCC827, HCC95, H1975, H2009, H3255, H358, A549, HCC44, H1299, H1703",0.0429076737250979 +"topoisomerase inhibitor",-0.3652,1.35373410556558,6.13480429899034e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H2126, H1299, H460",0.000587172288938228 +"cyclooxygenase inhibitor",-0.369666666666667,0.56398362016066,0.99999917867605,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"tubulin polymerization inhibitor",-0.428,1.35204506476036,7.0743649269666e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC15, H520",0.000587172288938228 +"MET inhibitor",-0.533,1.2487478871711,0.00105207995905694,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, HCC44",0.00513662568245446 +"src inhibitor",-0.594266666666667,1.45039051227428,5.4738702562375e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC827, HCC95, H2009, H358",0.000587172288938228 +"ALK tyrosine kinase receptor inhibitor",-0.612133333333333,0.963681769247998,0.224211661180687,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.395948252723341 +"bacterial 50S ribosomal subunit inhibitor",-0.6286,0.742863167557987,0.876568096064847,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902 +"RET tyrosine kinase inhibitor",-0.6768,1.16309968863992,0.0117308929723585,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, H520",0.0295049732335076 +"HSP inhibitor",-0.6854,1.25184354339624,0.000104530131970241,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, H358, HCC44",0.000723000079460835 +"PLK inhibitor",-0.703,1.6465416137208,1.64234033436046e-09,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,9,"HCC95, H1650, H1975, H2009, H2126, HCC15, H1299, H460, H520",7.84677705634712e-08 +"Abl kinase inhibitor",-0.719533333333333,0.999682654407792,0.0403688093965156,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0859131071771998 +"sterol demethylase inhibitor",-0.742533333333333,0.914146508003634,0.152412234108965,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.281115898467647 +"Bcr.Abl kinase inhibitor",-0.785066666666667,0.990250218499393,0.00515745474666957,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, A549",0.0147609911715026 diff --git a/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_results.csv b/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_results.csv new file mode 100644 index 0000000..9171bb8 --- /dev/null +++ b/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_results.csv @@ -0,0 +1,1246 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"HCC827","Pearson.est","EGFR inhibitor",-0.87589,-2.19,0,1339,0.00899,"brigatinib, GW.583340, BIBX.1382, CUDC.101, PD.153035, rociletinib, WZ8040, icotinib, AEE788, TAK.285, BIBU.1361, CP.724714, gefitinib, WZ.4002, ARRY.334543, AST.1306, BMS.599626, tucatinib, vandetanib, PD.168393, XL.647, erlotinib, neratinib, lapatinib, BMS.690514, dacomitinib, AZD8931, osimertinib, poziotinib, canertinib, pelitinib, afatinib",Inf,2.04624030826677,TRUE +"HCC827","Pearson.est","Abl kinase inhibitor",-0.53942,-1.35,0.172,1415,0.436,"dasatinib, bosutinib, ZM.306416",0.764471553092451,0.360513510731414,FALSE +"HCC827","Pearson.est","acetylcholine receptor agonist",0.35021,0.857,0.63,434,0.894,"tremorine, nicotine, nefiracetam",0.200659450546418,0.0486624812040823,FALSE +"HCC827","Pearson.est","acetylcholine receptor antagonist",0.65991,1.57,0.0344,444,0.36,"dicycloverine, methscopolamine, iododexetimide, darifenacin, diphemanil",1.46344155742847,0.443697499232713,FALSE +"HCC827","Pearson.est","adenosine receptor antagonist",-0.50206,-1.25,0.224,1354,0.514,"MRS.1220, CGS.15943",0.649751981665837,0.289036881004724,FALSE +"HCC827","Pearson.est","adrenergic receptor agonist",-0.33107,-0.828,0.649,1133,0.965,"epinephrine, midodrine, metaraminol, isoxsuprine",0.187755303199631,0.0154726866562074,FALSE +"HCC827","Pearson.est","adrenergic receptor antagonist",0.2948,0.737,0.797,406,0.947,"metoprolol, atenolol......, levobunolol, carvedilol, idazoxan, oxprenolol, atenolol....",0.0985416786038876,0.0236500209967266,FALSE +"HCC827","Pearson.est","AKT inhibitor",-0.53725,-1.32,0.183,1070,0.446,"palomid.529, GSK2110183, AZD5363, A.674563, CCT128930, GDC.0068, uprosertib, triciribine",0.737548910269571,0.350665141287858,FALSE +"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.61832,-1.53,0.071,1280,0.326,"NVP.TAE684, CEP.37440, brigatinib, GW.788388, AP26113, AZD3463",1.14874165128092,0.486782399932061,FALSE +"HCC827","Pearson.est","androgen receptor antagonist",0.44791,1.1,0.342,553,0.757,"nilutamide, flutamide, bicalutamide",0.465973893943865,0.120904120499927,FALSE +"HCC827","Pearson.est","antioxidant",0.44847,1.11,0.328,496,0.768,"taurine, chlorogenic.acid",0.484126156288321,0.114638779968488,FALSE +"HCC827","Pearson.est","AP inhibitor",0.48078,1.16,0.287,351,0.694,"idronoxil, GDC.0152, LCL.161, birinapant",0.542118103266008,0.158640529545145,FALSE +"HCC827","Pearson.est","ATPase inhibitor",0.62145,1.54,0.058,417,0.336,"digoxin, oligomycin.a, digitoxigenin, digitoxin, blebbistatin...., evodiamine, ouabain, NMS.873",1.23657200643706,0.473660722610156,FALSE +"HCC827","Pearson.est","Aurora kinase inhibitor",0.26912,0.644,0.902,227,1,"MK.5108, barasertib, barasertib.HQPA, SNS.314",0.0447934624580583,0,FALSE +"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.24339,0.6,0.929,426,1,"valnemulin, radezolid, josamycin",0.0319842860063582,0,FALSE +"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",-0.24101,-0.606,0.912,1331,0.94,"finafloxacin",0.0400051616715838,0.0268721464003014,FALSE +"HCC827","Pearson.est","BCL inhibitor",0.4275,1.03,0.397,265,0.751,"ABT.737, TW.37, gossypol, venetoclax",0.401209493236885,0.124360062995832,FALSE +"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",-0.44138,-1.11,0.329,1415,0.68,"dasatinib, bosutinib",0.482804102050026,0.167491087293764,FALSE +"HCC827","Pearson.est","benzodiazepine receptor agonist",0.24458,0.587,0.927,529,1,"bentazepam, indiplon, zaleplon, nefiracetam, CL.218872, lorazepam",0.0329202658555029,0,FALSE +"HCC827","Pearson.est","bromodomain inhibitor",-0.26859,-0.659,0.849,919,0.944,"PFI.1, OTX015, I.BET151, I.BET.762, JQ1....",0.0710923097560473,0.025028005701931,FALSE +"HCC827","Pearson.est","calcium channel blocker",0.49347,1.2,0.266,103,0.674,"carboxyamidotriazole, pranidipine, mibefradil",0.575118363368933,0.17134010346468,FALSE +"HCC827","Pearson.est","CC chemokine receptor antagonist",0.35363,0.871,0.612,326,0.893,"SB.225002, UNBS.5162",0.213248577854439,0.0491485411114536,FALSE +"HCC827","Pearson.est","CDK inhibitor",0.17028,0.423,0.996,693,0.995,"abemaciclib, dinaciclib, NU6027, palbociclib, P276.00, R547, indirubin, BMS.387032, AZD5438, PHA.848125, ribociclib",0.00174066157630127,0.00217691925427455,FALSE +"HCC827","Pearson.est","CHK inhibitor",-0.45868,-1.1,0.35,1210,0.658,"CHIR.124, LY2603618",0.455931955649724,0.181774106386044,FALSE +"HCC827","Pearson.est","cyclooxygenase inhibitor",-0.2862,-0.697,0.815,1240,0.926,"tryptanthrin, FK.3311, ketoprofen, aspirin, phenazone, ramifenazone",0.0888423912600234,0.0333890133180656,FALSE +"HCC827","Pearson.est","cytochrome P450 inhibitor",0.67592,1.64,0.0409,474,0.825,"metyrapone, clotrimazole, cobicistat, morin, itraconazole, eplerenone, PF.4981517",1.38827669199266,0.0835460514500749,FALSE +"HCC827","Pearson.est","DNA alkylating agent",0.47989,1.17,0.288,244,0.705,"carboplatin, carmustine, dianhydrogalactitol, TH.302, temozolomide, streptozotocin, cisplatin",0.540607512240769,0.151810883008601,FALSE +"HCC827","Pearson.est","DNA inhibitor",0.51846,1.26,0.206,153,0.618,"pibenzimol, carboplatin, chlorambucil, carmustine, valrubicin",0.686132779630847,0.209011524911184,FALSE +"HCC827","Pearson.est","DNA methyltransferase inhibitor",-0.43421,-1.08,0.346,1262,0.655,"azacitidine, SGI.1027, fdcyd, decitabine",0.460923901207223,0.183758700008217,FALSE +"HCC827","Pearson.est","DNA polymerase inhibitor",0.27659,0.681,0.861,206,1,"menadione, foscarnet",0.0649968485463452,0,FALSE +"HCC827","Pearson.est","DNA synthesis inhibitor",0.56241,1.39,0.115,430,0.522,"altretamine, artemisinin, cisplatin, cyclocytidine, azodicarbonamide, nelarabine, artesunate, estramustine.phosphate",0.939302159646388,0.282329496997738,FALSE +"HCC827","Pearson.est","dopamine receptor antagonist",0.3726,0.922,0.531,151,0.852,"raclopride, paliperidone, amisulpride, isofloxythepin",0.274905478918531,0.0695604052332999,FALSE +"HCC827","Pearson.est","estrogen receptor agonist",-0.23101,-0.588,0.923,1167,0.926,"ethinyl.estradiol, levonorgestrel",0.0347982989740879,0.0333890133180656,FALSE +"HCC827","Pearson.est","estrogen receptor antagonist",0.30921,0.742,0.776,222,0.962,"fulvestrant, danazol",0.110138278741812,0.0168249279621871,FALSE +"HCC827","Pearson.est","FGFR inhibitor",0.53219,1.29,0.185,479,0.627,"erdafitinib, dovitinib, orantinib, regorafenib, lenvatinib, nintedanib",0.732828271596986,0.202732459169284,FALSE +"HCC827","Pearson.est","FLT3 inhibitor",0.32677,0.777,0.732,671,0.932,"dovitinib, TG.101348, GTP.14564, ENMD.2076, ponatinib, tyrphostin.AG.1296, tozasertib, sunitinib, KW.2449, sorafenib, gilteritinib",0.135488918941608,0.0305840876460186,FALSE +"HCC827","Pearson.est","glucocorticoid receptor agonist",0.32466,0.778,0.708,404,0.954,"piretanide, dexamethasone.acetate, halcinonide, triamcinolone, prednisolone.hemisuccinate, flumethasone.pivalate, deflazacort, fluticasone.propionate",0.149966742310231,0.0204516252959049,FALSE +"HCC827","Pearson.est","glutamate receptor antagonist",0.43596,1.08,0.353,237,0.766,"felbamate, MTPG, CPP, ACDPP",0.452225294612177,0.115771230367396,FALSE +"HCC827","Pearson.est","glycogen synthase kinase inhibitor",-0.30594,-0.755,0.735,1403,0.94,"LY2090314",0.133712660915805,0.0268721464003014,FALSE +"HCC827","Pearson.est","growth factor receptor inhibitor",-0.48037,-1.2,0.241,1047,0.559,"GSK1904529A, GSK1838705A, AZD3463",0.617982957425132,0.252588192113577,FALSE +"HCC827","Pearson.est","HCV inhibitor",0.55059,1.34,0.158,201,0.598,"mericitabine, Ro.9187",0.801342913045577,0.223298816011589,FALSE +"HCC827","Pearson.est","HDAC inhibitor",-0.31618,-0.786,0.659,999,0.921,"chidamide, trichostatin.a, belinostat, vorinostat, RG2833, SB.939, PCI.24781, mocetinostat, tacedinaline, givinostat, panobinostat, JNJ.26481585",0.18111458540599,0.0357403698031511,FALSE +"HCC827","Pearson.est","histamine receptor antagonist",-0.29748,-0.752,0.746,1326,0.91,"ebastine, terfenadine, zolantidine, ranitidine",0.127261172527331,0.0409586076789064,FALSE +"HCC827","Pearson.est","HMGCR inhibitor",0.92284,2.27,0,26,0.00108,"atorvastatin, mevastatin, fluvastatin, pitavastatin",Inf,2.96657624451305,TRUE +"HCC827","Pearson.est","HSP inhibitor",-0.62481,-1.6,0.0696,1223,0.315,"guanidine, XL888, KW.2478, PU.H71, alvespimycin, VER.49009, BIIB021, tanespimycin",1.15739076038944,0.501689446210399,FALSE +"HCC827","Pearson.est","JAK inhibitor",-0.32706,-0.792,0.67,1327,0.949,"LY2784544, CEP.33779, ruxolitinib",0.173925197299174,0.0227337875727074,FALSE +"HCC827","Pearson.est","KIT inhibitor",0.23204,0.556,0.949,409,0.991,"pazopanib, motesanib, cediranib, regorafenib, KI.8751, lenvatinib",0.0227337875727074,0.00392634551472468,FALSE +"HCC827","Pearson.est","MDM inhibitor",0.65014,1.58,0.0556,70,0.48,"AMG.232, idasanutlin, nutlin.3",1.25492520841794,0.318758762624413,FALSE +"HCC827","Pearson.est","MEK inhibitor",-0.57674,-1.46,0.0989,1087,0.316,"PD.98059, PD.0325901, selumetinib, MEK1.2.inhibitor, PD.198306, refametinib, AS.703026, AZD8330, PD.184352, TAK.733, Ro.4987655, trametinib",1.00480370840282,0.500312917381596,FALSE +"HCC827","Pearson.est","MET inhibitor",-0.57239,-1.47,0.0804,1150,0.333,"PF.04217903, LY2801653, INC.280",1.09474395125155,0.47755576649368,FALSE +"HCC827","Pearson.est","microtubule inhibitor",0.41152,1.01,0.434,430,0.738,"secnidazole, vinblastine, triclabendazole, vinflunine, estramustine.phosphate",0.362510270487489,0.131943638176958,FALSE +"HCC827","Pearson.est","mTOR inhibitor",0.25857,0.635,0.882,551,1,"ku.0063794, XL388, OSI.027, SB.2343, torin.1, deforolimus, AZD2014, WAY.600, MLN0128, PF.04691502, LY3023414, PI.103",0.0545314148681803,0,FALSE +"HCC827","Pearson.est","NFkB pathway inhibitor",0.49243,1.21,0.233,506,0.688,"BAY.11.7082, betulinic.acid, parthenolide, tyloxapol, curcumin, IKK.2.inhibitor.V, EVP4593",0.632644078973981,0.162411561764489,FALSE +"HCC827","Pearson.est","opioid receptor agonist",-0.28724,-0.701,0.823,1350,0.954,"ADL5859",0.0846001647877302,0.0204516252959049,FALSE +"HCC827","Pearson.est","p38 MAPK inhibitor",-0.77205,-1.92,0.00227,1128,0.0562,"talmapimod, CMPD.1, SB.242235, VX.702, SB.239063, TAK.715",2.64397414280688,1.25026368443094,TRUE +"HCC827","Pearson.est","PARP inhibitor",0.42298,1.01,0.441,466,0.738,"AG.14361, endo.IWR.1, AZD2461, talazoparib",0.355561410532161,0.131943638176958,FALSE +"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.36762,0.886,0.609,505,0.893,"pazopanib, dovitinib, motesanib, orantinib, CP.673451, SU014813, axitinib, regorafenib, KI.8751, linifanib, lenvatinib, ponatinib, nintedanib, telatinib",0.215382707367125,0.0491485411114536,FALSE +"HCC827","Pearson.est","phosphatase inhibitor",0.59026,1.43,0.112,164,0.478,"bis.maltolato.oxovanadium.IV., GSK2830371, menadione, BVT.948",0.950781977329818,0.320572103387881,FALSE +"HCC827","Pearson.est","phosphodiesterase inhibitor",0.41996,1.03,0.421,61,0.751,"anagrelide, GSK256066",0.375717904164332,0.124360062995832,FALSE +"HCC827","Pearson.est","PI3K inhibitor",-0.25894,-0.654,0.878,1303,0.92,"PIK.75, TG.100713, CH5132799, alpelisib, taselisib",0.0565054840938974,0.0362121726544447,FALSE +"HCC827","Pearson.est","PLK inhibitor",-0.33737,-0.835,0.617,1145,0.996,"BI.2536, HMN.214, NMS.1286937",0.209714835966758,0.00174066157630127,FALSE +"HCC827","Pearson.est","potassium channel blocker",0.42736,1.04,0.421,253,0.788,"mepivacaine, dofetilide",0.375717904164332,0.103473782510445,FALSE +"HCC827","Pearson.est","PPAR receptor agonist",0.44061,1.07,0.383,21,0.756,"clofibrate",0.416801226031377,0.121478204498793,FALSE +"HCC827","Pearson.est","progesterone receptor agonist",0.52352,1.28,0.188,261,0.609,"norethindrone, tanaproget, norethindrone.acetate, danazol, norgestrel",0.72584215073632,0.215382707367125,FALSE +"HCC827","Pearson.est","proteasome inhibitor",0.53942,1.32,0.161,144,0.598,"MG.132, oprozomib",0.79317412396815,0.223298816011589,FALSE +"HCC827","Pearson.est","protein synthesis inhibitor",0.32788,0.811,0.686,432,0.95,"mercaptopurine, florfenicol, brefeldin.a, harringtonine, thiostrepton, clofoctol, methacycline",0.163675884293248,0.0222763947111523,FALSE +"HCC827","Pearson.est","protein tyrosine kinase inhibitor",-0.77439,-1.88,0.0136,1334,0.0654,"NVP.TAE226, CP.724714, BMS.599626, AV.412",1.86646109162978,1.18442225167573,TRUE +"HCC827","Pearson.est","RAF inhibitor",0.66353,1.61,0.0344,78,0.667,"dabrafenib, vemurafenib, SB.590885, TAK.632, AZ.628",1.46344155742847,0.175874166083451,FALSE +"HCC827","Pearson.est","RET tyrosine kinase inhibitor",-0.59339,-1.5,0.0776,1430,0.327,"vandetanib",1.11013827874181,0.485452247339714,FALSE +"HCC827","Pearson.est","retinoid receptor agonist",-0.32268,-0.797,0.652,1273,0.982,"adarotene, tamibarotene, CD.437",0.18575240426808,0.00788851221305034,FALSE +"HCC827","Pearson.est","ribonucleotide reductase inhibitor",0.65337,1.59,0.0536,148,0.568,"cladribine, triapine, pentostatin, clofarabine, hydroxyurea",1.27083521030723,0.245651664288981,FALSE +"HCC827","Pearson.est","serotonin receptor agonist",0.64701,1.57,0.0552,1,0.36,"aripiprazole",1.2580609222708,0.443697499232713,FALSE +"HCC827","Pearson.est","serotonin receptor antagonist",0.62152,1.54,0.0617,89,0.336,"aripiprazole, lerisetron, paliperidone, pirenperone",1.20971483596676,0.473660722610156,FALSE +"HCC827","Pearson.est","sodium channel blocker",0.60362,1.51,0.0669,186,0.357,"cibenzoline, butamben, mepivacaine, benzethonium, quinidine, oxcarbazepine",1.17457388223218,0.447331783887807,FALSE +"HCC827","Pearson.est","src inhibitor",-0.82886,-2.09,0,1415,0.0189,"dasatinib, bosutinib, ZM.306416, saracatinib",Inf,1.72353819582676,TRUE +"HCC827","Pearson.est","sterol demethylase inhibitor",0.40715,0.997,0.472,74,0.738,"posaconazole",0.326058001365912,0.131943638176958,FALSE +"HCC827","Pearson.est","TGF beta receptor inhibitor",-0.33738,-0.853,0.609,1110,1,"D.4476, SB.431542, repsox",0.215382707367125,0,FALSE +"HCC827","Pearson.est","thymidylate synthase inhibitor",0.22798,0.563,0.955,436,1,"doxifluridine, ftorafur",0.0199966284162537,0,FALSE +"HCC827","Pearson.est","topoisomerase inhibitor",0.32487,0.797,0.706,290,0.949,"doxorubicin, etoposide.phosphate, epirubicin, valrubicin, beta.lapachone, voreloxin, dexrazoxane, nemorubicin, teniposide",0.151195298948196,0.0227337875727074,FALSE +"HCC827","Pearson.est","tubulin polymerization inhibitor",0.19021,0.459,0.995,309,1,"taltobulin, vindesine, vinblastine, vinorelbine, BNC105, verubulin",0.00217691925427455,0,FALSE +"HCC827","Pearson.est","tyrosine kinase inhibitor",-0.62052,-1.55,0.0748,1334,0.339,"NVP.TAE226, aminopurvalanol.a, tivantinib, dasatinib, CP.724714, BMS.599626, vandetanib, AV.412",1.12609840213554,0.469800301796918,FALSE +"HCC827","Pearson.est","VEGFR inhibitor",-0.41588,-1.01,0.451,1411,0.744,"AEE788, ZM.306416, vandetanib, XL.647, BMS.690514",0.345823458122039,0.128427064454121,FALSE +"HCC827","Pearson.est","vitamin D receptor agonist",-0.81049,-1.95,0,1246,0.0569,"calcitriol, paricalcitol, tacalcitol, ercalcitriol, maxacalcitol",Inf,1.24488773360493,TRUE +"HCC95","Pearson.est","EGFR inhibitor",-0.79651,-1.91,0.00531,1326,0.0578,"WZ.4002, BMS.599626, icotinib, GW.583340, BIBX.1382, rociletinib, tucatinib, CP.724714, TAK.285, brigatinib, ARRY.334543, AEE788, PD.168393, vandetanib, gefitinib, AST.1306, osimertinib, canertinib, neratinib, pelitinib, dacomitinib, BMS.690514, AZD8931, erlotinib, afatinib, poziotinib, lapatinib, XL.647",2.27490547891853,1.23807216157947,TRUE +"HCC95","Pearson.est","Abl kinase inhibitor",-0.64044,-1.54,0.0724,1237,0.2,"metatinib, imatinib, tozasertib, ZM.306416, dasatinib, bosutinib",1.14026143380285,0.698970004336019,FALSE +"HCC95","Pearson.est","acetylcholine receptor agonist",0.32434,0.896,0.543,191,0.706,"nicotine, nefiracetam",0.265200170411153,0.151195298948196,FALSE +"HCC95","Pearson.est","acetylcholine receptor antagonist",0.56651,1.57,0.0556,287,0.252,"diphemanil, dicycloverine, iododexetimide",1.25492520841794,0.598599459218456,FALSE +"HCC95","Pearson.est","adenosine receptor antagonist",-0.49369,-1.19,0.259,1406,0.479,"CGS.15943",0.586700235918748,0.319664486585437,FALSE +"HCC95","Pearson.est","adrenergic receptor agonist",-0.295,-0.701,0.812,773,0.959,"metaraminol, oxymetazoline, norepinephrine, A61603, epinephrine, clenbuterol, midodrine, isoxsuprine, buphenine",0.0904439707588247,0.0181813928293364,FALSE +"HCC95","Pearson.est","adrenergic receptor antagonist",-0.27045,-0.631,0.883,869,0.973,"dihydroergocristine, pindolol, atipamezole, dronedarone, vincamine, idazoxan, naftidrofuryl, RS.17053, practolol",0.0540392964224314,0.0118871597316481,FALSE +"HCC95","Pearson.est","AKT inhibitor",-0.46959,-1.09,0.384,1058,0.612,"ONC201, A.674563, CCT128930, uprosertib, triciribine",0.415668775632469,0.213248577854439,FALSE +"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.65596,-1.56,0.0427,1096,0.287,"alectinib, SB.505124, NVP.TAE684, lorlatinib, GW.788388, crizotinib, AZD3463, AP26113, brigatinib",1.36957212497498,0.542118103266008,FALSE +"HCC95","Pearson.est","androgen receptor antagonist",0.47349,1.34,0.142,355,0.328,"bicalutamide, nilutamide, RU.58841, flutamide",0.847711655616944,0.484126156288321,FALSE +"HCC95","Pearson.est","antioxidant",0.51443,1.44,0.131,340,0.273,"trolox, benfotiamine, mesna, taurine",0.882728704344236,0.563837352959244,FALSE +"HCC95","Pearson.est","AP inhibitor",0.6975,1.96,0.0198,251,0.098,"idronoxil, GDC.0152, LCL.161",1.70333480973847,1.00877392430751,TRUE +"HCC95","Pearson.est","ATPase inhibitor",-0.19584,-0.469,0.989,1158,1,"digitoxigenin, k.strophanthidin",0.0048037084028206,0,FALSE +"HCC95","Pearson.est","Aurora kinase inhibitor",-0.56769,-1.36,0.146,903,0.356,"ZM.447439, MLN.8054, KW.2449, AT.9283, alisertib, MK.8745, ENMD.2076, aurora.a.inhibitor.i, TAK.901, CCT129202, PF.03814735, CYC116, barasertib, PHA.680632, danusertib, tozasertib, GSK1070916, hesperadin",0.835647144215563,0.448550002027125,FALSE +"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.43856,-1.06,0.379,1129,0.628,"azithromycin, tedizolid",0.421360790031928,0.202040356262804,FALSE +"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.42097,1.14,0.311,278,0.471,"sparfloxacin, norfloxacin, sarafloxacin, nadifloxacin",0.507239610973163,0.326979092871104,FALSE +"HCC95","Pearson.est","BCL inhibitor",0.2468,0.674,0.841,20,0.908,"ABT.737",0.0752040042020878,0.0419141514789149,FALSE +"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.64196,-1.54,0.0461,1237,0.2,"metatinib, imatinib, tozasertib, dasatinib, bosutinib",1.33629907461035,0.698970004336019,TRUE +"HCC95","Pearson.est","benzodiazepine receptor agonist",0.4647,1.27,0.18,191,0.381,"indiplon, zaleplon, temazepam, nefiracetam",0.744727494896694,0.419075024324381,FALSE +"HCC95","Pearson.est","bromodomain inhibitor",0.52547,1.45,0.128,246,0.288,"bromosporine, I.BET151, PFI.1",0.892790030352132,0.540607512240769,FALSE +"HCC95","Pearson.est","calcium channel blocker",-0.35359,-0.843,0.666,1223,0.819,"SKF.96365, penfluridol",0.176525770829699,0.0867160982395816,FALSE +"HCC95","Pearson.est","CC chemokine receptor antagonist",0.22396,0.62,0.902,84,0.936,"SB.225002",0.0447934624580583,0.0287241512618947,FALSE +"HCC95","Pearson.est","CDK inhibitor",-0.55669,-1.33,0.154,959,0.368,"dinaciclib, ribociclib, BMS.387032, AZD5438, JNJ.7706621, BMS.265246, R547, palbociclib, alvocidib, PHA.793887, AT.7519, aminopurvalanol.a, PHA.848125, indisulam",0.812479279163537,0.434152181326482,FALSE +"HCC95","Pearson.est","CHK inhibitor",-0.38846,-0.93,0.569,782,0.779,"LY2606368, AZD7762, CHIR.124, LY2603618",0.244887733604929,0.108462542327436,FALSE +"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.19378,-0.464,0.985,1062,0.988,"AM.404, ramifenazone, FK.3311, amfenac, aspirin, phenazone",0.00656376950238827,0.00524305541237188,FALSE +"HCC95","Pearson.est","cytochrome P450 inhibitor",0.55149,1.48,0.0952,339,0.284,"metyrapone, clotrimazole, cobicistat, morin",1.02136305161553,0.546681659952962,FALSE +"HCC95","Pearson.est","DNA alkylating agent",-0.43797,-1.05,0.403,1189,0.608,"estramustine, cyclophosphamide, mitomycin.c, dacarbazine",0.39469495385889,0.216096420727265,FALSE +"HCC95","Pearson.est","DNA inhibitor",0.44048,1.19,0.276,258,0.431,"pibenzimol, chlorambucil, bendamustine, melphalan, carboplatin",0.559090917934782,0.365522729839268,FALSE +"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.64487,-1.54,0.045,1317,0.2,"fdcyd, azacitidine, decitabine",1.34678748622466,0.698970004336019,TRUE +"HCC95","Pearson.est","DNA polymerase inhibitor",0.29477,0.79,0.646,29,0.86,"menadione",0.189767482004916,0.0655015487564323,FALSE +"HCC95","Pearson.est","DNA synthesis inhibitor",-0.29483,-0.703,0.812,875,0.979,"altretamine, floxuridine, cyclocytidine, CB.10.277, enocitabine, capecitabine, anisomycin, mitomycin.c",0.0904439707588247,0.00921730819686218,FALSE +"HCC95","Pearson.est","dopamine receptor antagonist",0.341,0.942,0.497,343,0.66,"amisulpride, raclopride, sertindole, domperidone, paliperidone, remoxipride, nemonapride, lurasidone",0.303643611266668,0.180456064458131,FALSE +"HCC95","Pearson.est","estrogen receptor agonist",-0.433,-1.03,0.417,1112,0.623,"ethinyl.estradiol, levonorgestrel",0.379863945026242,0.20551195334083,FALSE +"HCC95","Pearson.est","estrogen receptor antagonist",0.49594,1.34,0.158,250,0.328,"toremifene, fulvestrant, danazol",0.801342913045577,0.484126156288321,FALSE +"HCC95","Pearson.est","FGFR inhibitor",-0.38835,-0.911,0.568,923,0.769,"nintedanib, AZD4547, MK.2461, PD.173074, dovitinib, lenvatinib, lucitanib",0.245651664288981,0.114073660198569,FALSE +"HCC95","Pearson.est","FLT3 inhibitor",-0.45795,-1.11,0.338,850,0.596,"tyrphostin.AG.1296, quizartinib, ponatinib, lestaurtinib, KW.2449, sunitinib, dovitinib, gilteritinib, ENMD.2076, midostaurin, pacritinib, sorafenib, tozasertib",0.471083299722345,0.224753740259764,FALSE +"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.24566,-0.592,0.925,777,0.966,"rimexolone, fluocinolone.acetonide, methylprednisolone, fludroxycortide, fluticasone.propionate, flumethasone.pivalate, desonide, prednisolone.acetate, clobetasol.propionate, halobetasol.propionate, difluprednate, hydrocortisone, fluorometholone, triamcinolone.acetonide, betamethasone, ciclesonide, flumethasone",0.0338582672609674,0.0150228735845067,FALSE +"HCC95","Pearson.est","glutamate receptor antagonist",0.34253,0.949,0.503,269,0.677,"MTPG, ACDPP, JNJ.16259685, felbamate, IEM1754",0.298432014944073,0.169411331314856,FALSE +"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.2467,0.676,0.839,1093,0.937,"CHIR.98014, CHIR.99021, GSK.3.inhibitor.IX, indirubin, tideglusib, kenpaullone, AZD2858, TWS.119, LY2090314",0.0762380391712997,0.0282604091122217,FALSE +"HCC95","Pearson.est","growth factor receptor inhibitor",-0.64875,-1.57,0.0431,1185,0.306,"GSK1838705A, danusertib, AZD3463, PHA.848125",1.36552272983927,0.51427857351842,FALSE +"HCC95","Pearson.est","HCV inhibitor",0.57327,1.57,0.0686,120,0.252,"mericitabine, Ro.9187",1.16367588429325,0.598599459218456,FALSE +"HCC95","Pearson.est","HDAC inhibitor",-0.35418,-0.856,0.65,860,0.818,"RGFP966, trichostatin.a, JNJ.26481585, SB.939, romidepsin, panobinostat, tacedinaline, givinostat, resminostat, dacinostat, belinostat, vorinostat, chidamide",0.187086643357144,0.087246696328677,FALSE +"HCC95","Pearson.est","histamine receptor antagonist",-0.28589,-0.684,0.839,1027,0.938,"terfenadine, BF2.649, ranitidine, zolantidine, ebastine, levocetirizine",0.0762380391712997,0.0277971616209356,FALSE +"HCC95","Pearson.est","HMGCR inhibitor",0.7865,2.15,0.0134,285,0.101,"atorvastatin, mevastatin, fluvastatin, simvastatin, pitavastatin",1.87289520163519,0.995678626217357,TRUE +"HCC95","Pearson.est","HSP inhibitor",-0.70905,-1.73,0.0231,1220,0.162,"alvespimycin, XL888, tanespimycin, ganetespib, NVP.AUY922, VER.49009, PU.H71, BIIB021",1.63638802010786,0.790484985457369,TRUE +"HCC95","Pearson.est","JAK inhibitor",-0.56921,-1.38,0.125,910,0.412,"lestaurtinib, TG.101209, filgotinib, PRT062070, AT.9283, AZ960, LY2784544, baricitinib, WHI.P154, AZD1480, pacritinib, tozasertib, CEP.33779, ruxolitinib",0.903089986991944,0.385102783966865,FALSE +"HCC95","Pearson.est","KIT inhibitor",-0.50623,-1.2,0.261,1184,0.48,"lenvatinib, midostaurin, sorafenib, imatinib, dasatinib",0.583359492661719,0.318758762624413,FALSE +"HCC95","Pearson.est","MDM inhibitor",0.74932,2.04,0.00397,150,0.0742,"AMG.232, idasanutlin, CGM097, nutlin.3",2.40120949323688,1.12959609472097,TRUE +"HCC95","Pearson.est","MEK inhibitor",0.57934,1.58,0.0584,220,0.313,"U.0126, cobimetinib, selumetinib, MEK1.2.inhibitor, BIX.02188, MEK162, refametinib, AS.703026, PD.318088",1.2335871528876,0.504455662453552,FALSE +"HCC95","Pearson.est","MET inhibitor",-0.6514,-1.57,0.048,1388,0.306,"INC.280, LY2801653",1.31875876262441,0.51427857351842,FALSE +"HCC95","Pearson.est","microtubule inhibitor",-0.58123,-1.38,0.118,958,0.412,"vinblastine, cytochalasin.b, triclabendazole, colchicine, vinflunine, podophyllotoxin, D.64131, cabazitaxel",0.928117992693875,0.385102783966865,FALSE +"HCC95","Pearson.est","mTOR inhibitor",-0.37838,-0.903,0.584,905,0.762,"PKI.179, MLN0128, temsirolimus, WYE.354, NVP.BEZ235, torin.1, voxtalisib, GSK2126458, AZD8055, GDC.0980, PF.05212384, sirolimus, deforolimus, everolimus, torin.2",0.233587152887601,0.1180450286604,FALSE +"HCC95","Pearson.est","NFkB pathway inhibitor",0.35237,0.951,0.492,942,0.704,"tyloxapol, BAY.11.7082, parthenolide, parthenolide...., IKK.2.inhibitor.V, bindarit, bortezomib, betulinic.acid, Ro.106.9920, curcumin, BAY.11.7085, EVP4593",0.30803489723264,0.152427340857888,FALSE +"HCC95","Pearson.est","opioid receptor agonist",0.39186,1.09,0.336,42,0.522,"BW.180C",0.473660722610156,0.282329496997738,FALSE +"HCC95","Pearson.est","p38 MAPK inhibitor",-0.51498,-1.23,0.235,879,0.464,"skepinone.l, CMPD.1, SB.239063, SB.242235, talmapimod",0.628932137728264,0.333482019445119,FALSE +"HCC95","Pearson.est","PARP inhibitor",-0.56036,-1.36,0.138,1279,0.356,"niraparib, olaparib, talazoparib",0.860120913598763,0.448550002027125,FALSE +"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.44813,-1.08,0.369,1184,0.611,"lenvatinib, axitinib, crenolanib, sorafenib, imatinib, CP.673451, dasatinib",0.43297363384094,0.213958789757446,FALSE +"HCC95","Pearson.est","phosphatase inhibitor",0.56564,1.55,0.0752,56,0.244,"bis.maltolato.oxovanadium.IV., menadione, BVT.948, GSK2830371",1.12378215940836,0.612610173661271,FALSE +"HCC95","Pearson.est","phosphodiesterase inhibitor",0.36521,0.998,0.403,143,0.649,"anagrelide, enoximone, GSK256066",0.39469495385889,0.187755303199631,FALSE +"HCC95","Pearson.est","PI3K inhibitor",-0.38275,-0.924,0.539,1033,0.768,"NVP.BEZ235, GDC.0941, voxtalisib, GSK2126458, GDC.0980, PF.05212384, TG.100713, taselisib, PIK.75, CH5132799, alpelisib",0.268411234813261,0.114638779968488,FALSE +"HCC95","Pearson.est","PLK inhibitor",-0.79433,-1.9,0,1264,0.0431,"HMN.214, GSK461364, BI.2536, rigosertib, volasertib, NMS.1286937",Inf,1.36552272983927,TRUE +"HCC95","Pearson.est","potassium channel blocker",-0.33921,-0.819,0.689,1261,0.837,"ibutilide",0.161780778092374,0.07727454200674,FALSE +"HCC95","Pearson.est","PPAR receptor agonist",0.60692,1.68,0.0435,265,0.312,"GW.501516, fenofibrate, pterostilbene, clofibrate",1.36151074304536,0.505845405981557,FALSE +"HCC95","Pearson.est","progesterone receptor agonist",0.59248,1.67,0.0365,40,0.268,"norethindrone.acetate, norgestrel, norethindrone, tanaproget",1.43770713554353,0.571865205971211,FALSE +"HCC95","Pearson.est","proteasome inhibitor",0.44129,1.23,0.198,238,0.406,"oprozomib, ONX.0914, MG.132",0.703334809738469,0.391473966422806,FALSE +"HCC95","Pearson.est","protein synthesis inhibitor",-0.507,-1.2,0.251,1162,0.48,"anguidine, thiostrepton, bruceantin, tedizolid.phosphate, homoharringtonine, puromycin, cycloheximide",0.600326278518962,0.318758762624413,FALSE +"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.71356,-1.7,0.00997,1293,0.167,"NVP.TAE226, BMS.599626, CP.724714, AV.412",2.00130484168834,0.777283528852417,TRUE +"HCC95","Pearson.est","RAF inhibitor",0.79542,2.14,0,92,0.0553,"dabrafenib, vemurafenib, AZ.628, GDC.0879, LGX818, PLX.4720, SB.590885, TAK.632",Inf,1.2572748686953,TRUE +"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.65561,-1.55,0.0442,1200,0.245,"cabozantinib, sorafenib, vandetanib",1.35457773065091,0.610833915635468,TRUE +"HCC95","Pearson.est","retinoid receptor agonist",-0.2603,-0.619,0.902,1126,0.964,"tamibarotene, CD.437",0.0447934624580583,0.0159229660971692,FALSE +"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.2533,0.703,0.776,170,0.935,"pentostatin, triapine",0.110138278741812,0.0291883891274822,FALSE +"HCC95","Pearson.est","serotonin receptor agonist",-0.5594,-1.34,0.156,1179,0.37,"pardoprunox, aripiprazole",0.806875401645538,0.431798275933005,FALSE +"HCC95","Pearson.est","serotonin receptor antagonist",-0.28985,-0.691,0.827,1192,0.95,"RS.16566, SB.200646, SB.228357, aripiprazole",0.0824944904474534,0.0222763947111523,FALSE +"HCC95","Pearson.est","sodium channel blocker",0.27707,0.747,0.74,63,0.9,"cibenzoline, benzethonium",0.130768280269024,0.0457574905606751,FALSE +"HCC95","Pearson.est","src inhibitor",-0.83057,-1.99,0,1414,0.0308,"ZM.306416, dasatinib, bosutinib, saracatinib",Inf,1.51144928349956,TRUE +"HCC95","Pearson.est","sterol demethylase inhibitor",-0.53227,-1.28,0.212,999,0.397,"ketoconazole, terconazole, lanoconazole",0.673664139071249,0.401209493236885,FALSE +"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.43307,-1.05,0.405,1149,0.608,"D.4476, repsox",0.392544976785331,0.216096420727265,FALSE +"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.57623,-1.36,0.109,1151,0.356,"capecitabine, raltitrexed, carmofur",0.962573502059376,0.448550002027125,FALSE +"HCC95","Pearson.est","topoisomerase inhibitor",-0.54554,-1.3,0.175,1040,0.4,"amonafide, licochalcone.a, daunorubicin, topotecan, idarubicin, TAS.103, etoposide, rubitecan, mitoxantrone, dexrazoxane, amsacrine, exatecan.mesylate, SN.38, genz.644282, camptothecin, irinotecan",0.756961951313706,0.397940008672038,FALSE +"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.65453,-1.55,0.051,1068,0.245,"albendazole, flubendazole, vincristine, fenbendazole, ABT.751, CYT.997, epothilone.d, podophyllotoxin, BNC105, nocodazole, dolastatin.10, vinorelbine, plinabulin, indibulin, mebendazole, epothilone.b, parbendazole, fosbretabulin, paclitaxel, docetaxel",1.29242982390206,0.610833915635468,FALSE +"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.57025,-1.37,0.118,1293,0.404,"NVP.TAE226, sorafenib, BMS.599626, aminopurvalanol.a, CP.724714, vandetanib, dasatinib, tivantinib, AV.412",0.928117992693875,0.393618634889395,FALSE +"HCC95","Pearson.est","VEGFR inhibitor",-0.53907,-1.28,0.188,984,0.397,"sunitinib, OSI.930, MK.2461, PD.173074, dovitinib, linifanib, ENMD.2076, TG.100572, lenvatinib, golvatinib, cabozantinib, axitinib, foretinib, sorafenib, lucitanib, tivozanib, ZM.306416, AEE788, vandetanib, BMS.690514, XL.647",0.72584215073632,0.401209493236885,FALSE +"HCC95","Pearson.est","vitamin D receptor agonist",0.19292,0.544,0.945,1170,0.964,"doxercalciferol, tacalcitol, alfacalcidol, paricalcitol, calcitriol, ercalcitriol, maxacalcitol",0.0245681914907371,0.0159229660971692,FALSE +"H1650","Pearson.est","EGFR inhibitor",-0.54931,-1.61,0.0588,1198,0.294,"ARRY.334543, BMS.599626, FERb.033, gefitinib, neratinib, PD.153035, brigatinib, tyrphostin.AG.494, poziotinib, afatinib, AZD8931, WZ8040, WZ.4002, dacomitinib, pelitinib, BIBU.1361, vandetanib, erlotinib, icotinib, lapatinib, osimertinib, PD.168393, XL.647, BMS.690514, canertinib",1.23062267392386,0.531652669587843,FALSE +"H1650","Pearson.est","Abl kinase inhibitor",-0.36567,-1.05,0.374,1268,0.728,"ponatinib, bosutinib, ZM.306416, dasatinib",0.42712839779952,0.137868620686963,FALSE +"H1650","Pearson.est","acetylcholine receptor agonist",0.40273,0.968,0.507,455,0.838,"xanomeline, tremorine, oxiracetam",0.294992040666664,0.0767559813697235,FALSE +"H1650","Pearson.est","acetylcholine receptor antagonist",-0.73677,-2.08,0.00976,1305,0.095,"iododexetimide, hyoscyamine, dicycloverine",2.01055018233331,1.02227639471115,TRUE +"H1650","Pearson.est","adenosine receptor antagonist",0.40564,0.96,0.549,581,0.83,"SCH.58261, sulmazole, PSB.1115, istradefylline, MRS.1220",0.260427655549908,0.0809219076239261,FALSE +"H1650","Pearson.est","adrenergic receptor agonist",-0.34497,-0.941,0.513,1310,0.811,"oxymetazoline, xylazine, ritodrine, isoetharine, midodrine, isoxsuprine",0.289882634888184,0.090979145788844,FALSE +"H1650","Pearson.est","adrenergic receptor antagonist",0.3147,0.755,0.779,389,0.971,"carvedilol, oxprenolol, atipamezole, atenolol......, dihydroergocristine, idazoxan",0.108462542327436,0.0127807700919951,FALSE +"H1650","Pearson.est","AKT inhibitor",0.32673,0.779,0.734,572,0.959,"uprosertib, GDC.0068, A.674563, ONC201, MK.2206",0.134303940083929,0.0181813928293364,FALSE +"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.34001,-0.997,0.427,1255,0.739,"AP26113, brigatinib, lorlatinib, GW.788388",0.369572124974976,0.131355561605174,FALSE +"H1650","Pearson.est","androgen receptor antagonist",-0.68867,-2.03,0,1102,0.0857,"cyproterone.acetate, flutamide, bicalutamide, RU.58841",Inf,1.0670191780768,TRUE +"H1650","Pearson.est","antioxidant",-0.43481,-1.26,0.187,627,0.547,"taurine, mesna, chlorogenic.acid, rutin, trolox, benfotiamine",0.728158393463501,0.262012673666569,FALSE +"H1650","Pearson.est","AP inhibitor",0.30252,0.71,0.828,673,1,"idronoxil, tanshinone.i, birinapant",0.0819696632151199,0,FALSE +"H1650","Pearson.est","ATPase inhibitor",0.66106,1.57,0.0373,139,0.216,"NMS.873, evodiamine, oligomycin.a, digoxin, thonzonium",1.42829116819131,0.665546248849069,TRUE +"H1650","Pearson.est","Aurora kinase inhibitor",0.6765,1.6,0.0295,446,0.262,"danusertib, TAK.901, barasertib.HQPA, PHA.680632, barasertib, SNS.314, CCT137690, AMG900, GSK1070916, MK.5108, KW.2449, alisertib, aurora.a.inhibitor.i, CCT129202, MK.8745, tozasertib, AT.9283, ENMD.2076, ZM.447439, hesperadin, CYC116",1.53017798402184,0.581698708680255,FALSE +"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.30536,-0.873,0.574,1415,0.765,"dirithromycin",0.241088107602027,0.116338564846382,FALSE +"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.26145,0.623,0.904,677,0.981,"trovafloxacin, lomefloxacin, novobiocin, nadifloxacin",0.0438315695246367,0.0083309926200515,FALSE +"H1650","Pearson.est","BCL inhibitor",0.2884,0.684,0.851,63,0.979,"TW.37",0.0700704399154121,0.00921730819686218,FALSE +"H1650","Pearson.est","Bcr.Abl kinase inhibitor",-0.37112,-1.12,0.259,1268,0.642,"ponatinib, bosutinib, dasatinib",0.586700235918748,0.192464971931147,FALSE +"H1650","Pearson.est","benzodiazepine receptor agonist",-0.23066,-0.682,0.844,331,0.889,"bentazepam, ZK.93423, piperazine, zaleplon, nefiracetam, indiplon, CL.218872, gamma.aminobutyric.acid, lorazepam, ivermectin, temazepam, CGS.20625, eprinomectin",0.073657553374345,0.0510982390297863,FALSE +"H1650","Pearson.est","bromodomain inhibitor",0.84397,1.99,0,231,0.0297,"OTX015, JQ1...., bromosporine, I.BET151, I.BET.762, PFI.1",Inf,1.52724355068279,TRUE +"H1650","Pearson.est","calcium channel blocker",0.33712,0.805,0.738,623,0.984,"carboxyamidotriazole, tetrandrine, penfluridol, mibefradil, pranidipine, cinnarazine",0.131943638176958,0.00700490156865849,FALSE +"H1650","Pearson.est","CC chemokine receptor antagonist",0.50737,1.2,0.236,451,0.553,"SB.225002, RS.504393, PF.04136309, UNBS.5162",0.627087997029893,0.257274868695302,FALSE +"H1650","Pearson.est","CDK inhibitor",0.51548,1.23,0.204,539,0.531,"indisulam, BMS.387032, dinaciclib, arcyriaflavin.a, JNJ.7706621, PHA.793887, abemaciclib, indirubin, PHA.848125, P276.00, palbociclib, aminopurvalanol.a, AT.7519, TG.02, R547, BMS.265246",0.690369832574101,0.274905478918531,FALSE +"H1650","Pearson.est","CHK inhibitor",0.37845,0.888,0.611,302,0.954,"SB.218078, PF.477736",0.213958789757446,0.0204516252959049,FALSE +"H1650","Pearson.est","cyclooxygenase inhibitor",0.17886,0.426,0.988,502,0.994,"piroxicam, sulfasalazine, meloxicam, FR.122047, amfenac, suxibuzone, ramifenazone",0.00524305541237188,0.00261361560268669,FALSE +"H1650","Pearson.est","cytochrome P450 inhibitor",-0.53336,-1.54,0.0761,1279,0.316,"eplerenone, clotrimazole, metyrapone",1.11861534322943,0.500312917381596,FALSE +"H1650","Pearson.est","DNA alkylating agent",0.56164,1.34,0.149,475,0.465,"mitomycin.c, satraplatin, estramustine, carmustine, cisplatin, dianhydrogalactitol, melphalan, TH.302",0.826813731587726,0.332547047110046,FALSE +"H1650","Pearson.est","DNA inhibitor",0.35751,0.845,0.664,172,0.985,"valrubicin, chlorambucil, pibenzimol, oxaliplatin",0.177831920631982,0.00656376950238827,FALSE +"H1650","Pearson.est","DNA methyltransferase inhibitor",0.56059,1.33,0.145,470,0.434,"fdcyd, disulfiram, SGI.1027, decitabine",0.838631997765025,0.362510270487489,FALSE +"H1650","Pearson.est","DNA polymerase inhibitor",0.52097,1.23,0.222,482,0.531,"cephalomannine, idoxuridine, trifluridine, adefovir.dipivoxil",0.653647025549361,0.274905478918531,FALSE +"H1650","Pearson.est","DNA synthesis inhibitor",0.42102,0.994,0.489,399,0.804,"floxuridine, cyclocytidine, mitomycin.c, anisomycin, cisplatin, enocitabine",0.31069114087638,0.0947439512515487,FALSE +"H1650","Pearson.est","dopamine receptor antagonist",-0.17648,-0.51,0.988,1254,0.982,"clebopride, oxiperomide, remoxipride, ziprasidone",0.00524305541237188,0.00788851221305034,FALSE +"H1650","Pearson.est","estrogen receptor agonist",-0.30406,-0.899,0.557,1402,0.798,"equol",0.254144804826271,0.0979971086492706,FALSE +"H1650","Pearson.est","estrogen receptor antagonist",-0.2972,-0.842,0.617,1413,0.782,"raloxifene",0.209714835966758,0.106793246940152,FALSE +"H1650","Pearson.est","FGFR inhibitor",0.5928,1.41,0.0903,357,0.402,"dovitinib, regorafenib, erdafitinib, nintedanib, PD.173074",1.04431224968649,0.39577394691553,FALSE +"H1650","Pearson.est","FLT3 inhibitor",0.54129,1.27,0.172,512,0.489,"dovitinib, lestaurtinib, TG.101348, KW.2449, pacritinib, tyrphostin.AG.1296, tozasertib, ENMD.2076, GTP.14564, sorafenib, TG.02",0.764471553092451,0.31069114087638,FALSE +"H1650","Pearson.est","glucocorticoid receptor agonist",-0.28599,-0.807,0.668,1339,0.81,"fluocinolone.acetonide, prednisolone.acetate, hydrocortisone",0.175223537524454,0.0915149811213502,FALSE +"H1650","Pearson.est","glutamate receptor antagonist",0.26338,0.622,0.91,194,0.964,"ACDPP, felbamate",0.0409586076789064,0.0159229660971692,FALSE +"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.25884,0.609,0.923,60,0.957,"AZD2858",0.0347982989740879,0.0190880622231565,FALSE +"H1650","Pearson.est","growth factor receptor inhibitor",0.63447,1.51,0.047,421,0.288,"danusertib, lestaurtinib, GSK1838705A, AZD3463, PHA.848125",1.32790214206428,0.540607512240769,FALSE +"H1650","Pearson.est","HCV inhibitor",0.36008,0.837,0.67,176,0.976,"mericitabine",0.173925197299174,0.0105501823333082,FALSE +"H1650","Pearson.est","HDAC inhibitor",0.67571,1.59,0.0338,381,0.241,"M.344, resminostat, PCI.24781, R306465, trichostatin.a, givinostat, NSC.3852, SB.939, AR.42, dacinostat, pyroxamide, nexturastat.a, belinostat, scriptaid, ACY.1215, chidamide, entinostat, vorinostat, panobinostat, RGFP966",1.47108329972235,0.617982957425132,TRUE +"H1650","Pearson.est","histamine receptor antagonist",-0.25758,-0.728,0.76,1229,0.903,"cimetidine, zolantidine, lafutidine, terfenadine, ranitidine, famotidine, chloropyramine",0.119186407719209,0.0443122496864942,FALSE +"H1650","Pearson.est","HMGCR inhibitor",-0.49704,-1.43,0.125,1277,0.398,"pitavastatin, lovastatin, simvastatin",0.903089986991944,0.400116927926312,FALSE +"H1650","Pearson.est","HSP inhibitor",0.33506,0.794,0.742,592,0.978,"NMS.E973, SNX.2112, SNX.5422, PU.H71, KW.2478, BIIB021",0.129596094720973,0.00966114521239857,FALSE +"H1650","Pearson.est","JAK inhibitor",0.51186,1.21,0.242,423,0.553,"WHI.P154, lestaurtinib, AZ960, TG.101348, TG.101209, pacritinib, tozasertib, AT.9283, baricitinib",0.616184634019569,0.257274868695302,FALSE +"H1650","Pearson.est","KIT inhibitor",0.33804,0.789,0.756,201,0.964,"OSI.930, regorafenib, pazopanib",0.121478204498793,0.0159229660971692,FALSE +"H1650","Pearson.est","MDM inhibitor",-0.31068,-0.889,0.55,448,0.775,"serdemetan, idasanutlin, nutlin.3, AMG.232, RITA, CGM097",0.259637310505756,0.11069829749369,FALSE +"H1650","Pearson.est","MEK inhibitor",0.426,1.01,0.452,712,0.817,"PD.198306, MEK162, selumetinib, PD.318088, PD.0325901, PD.98059, U.0126, trametinib, Ro.4987655, AS.703026, AZD8330, cobimetinib, arctigenin, TAK.733",0.344861565188618,0.0877779434675845,FALSE +"H1650","Pearson.est","MET inhibitor",0.60259,1.42,0.0902,291,0.413,"PHA.665752, AMG458, NVP.BVU972",1.04479346245806,0.384049948343599,FALSE +"H1650","Pearson.est","microtubule inhibitor",0.55804,1.35,0.13,313,0.473,"D.64131, vinflunine, vinblastine, triclabendazole, cabazitaxel",0.886056647693163,0.325138859262188,FALSE +"H1650","Pearson.est","mTOR inhibitor",0.29581,0.703,0.851,538,0.998,"GSK2126458, PF.04691502, PI.103, deforolimus, PKI.179, ku.0063794, AZD2014, OSI.027, PP242, AZD8055, PF.05212384",0.0700704399154121,0.000869458712628891,FALSE +"H1650","Pearson.est","NFkB pathway inhibitor",0.44286,1.04,0.446,652,0.827,"EVP4593, parthenolide, BAY.11.7082, betulinic.acid, Ro.106.9920, parthenolide...., curcumin, bindarit",0.350665141287858,0.0824944904474534,FALSE +"H1650","Pearson.est","opioid receptor agonist",-0.31711,-0.907,0.526,1285,0.828,"BW.180C, ADL5859, cebranopadol",0.279014255846261,0.0819696632151199,FALSE +"H1650","Pearson.est","p38 MAPK inhibitor",0.45445,1.08,0.38,69,0.784,"talmapimod",0.42021640338319,0.105683937315562,FALSE +"H1650","Pearson.est","PARP inhibitor",0.67308,1.57,0.0272,335,0.216,"talazoparib, niraparib, olaparib, PJ.34, AZD2461",1.5654310959658,0.665546248849069,TRUE +"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.27382,0.649,0.869,282,0.996,"dovitinib, regorafenib, axitinib, pazopanib, nintedanib",0.0609802235513335,0.00174066157630127,FALSE +"H1650","Pearson.est","phosphatase inhibitor",0.42984,1,0.496,631,0.816,"alexidine, CID.5458317, sodium.stibogluconate, bis.maltolato.oxovanadium.IV., mycophenolate.mofetil, GSK2830371, menadione",0.304518323509803,0.0883098412461389,FALSE +"H1650","Pearson.est","phosphodiesterase inhibitor",-0.33727,-1,0.425,485,0.785,"enoximone, cilostamide, zardaverine, anagrelide, avanafil, EMD.53998, papaverine, GSK256066, YM.976, trequinsin",0.371611069949688,0.105130343254747,FALSE +"H1650","Pearson.est","PI3K inhibitor",0.42922,1.02,0.45,690,0.82,"CUDC.907, GSK2126458, PF.04691502, buparlisib, PI.103, AZD6482, PKI.179, taselisib, PIK.75, alpelisib, GDC.0941, ZSTK.474, BGT226, CH5132799, pilaralisib, PF.05212384, YM.201636, SB.2343, TG.100713, idelalisib, PI3K.IN.2, voxtalisib",0.346787486224656,0.0861861476162833,FALSE +"H1650","Pearson.est","PLK inhibitor",0.80299,1.87,0.00498,56,0.0722,"BI.2536, volasertib, NMS.1286937, GW.843682X, rigosertib",2.30277065724028,1.14146280243036,TRUE +"H1650","Pearson.est","potassium channel blocker",-0.3828,-1.15,0.297,552,0.633,"dofetilide, mepivacaine, ML133, ibutilide, oleoylethanolamide, meglitinide",0.527243550682788,0.198596289982645,FALSE +"H1650","Pearson.est","PPAR receptor agonist",0.2374,0.564,0.942,578,0.969,"ciprofibrate, clofibrate, GW.501516",0.0259490972071227,0.0136762229492347,FALSE +"H1650","Pearson.est","progesterone receptor agonist",0.37721,0.878,0.644,684,0.948,"tanaproget, dienogest, norgestrel, danazol, nomegestrol.acetate, norethindrone",0.191114132640188,0.0231916626619338,FALSE +"H1650","Pearson.est","proteasome inhibitor",-0.24792,-0.701,0.822,357,0.903,"MG.132, ONX.0914, delanzomib, carfilzomib, bortezomib, ixazomib, oprozomib, ixazomib.citrate",0.0851281824599496,0.0443122496864942,FALSE +"H1650","Pearson.est","protein synthesis inhibitor",0.6642,1.6,0.0271,343,0.262,"anguidine, homoharringtonine, bruceantin, tedizolid.phosphate, harringtonine, azomycin..2.nitroimidazole., thiostrepton, clofoctol, cycloheximide, puromycin, emetine",1.56703070912559,0.581698708680255,FALSE +"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.44188,1.05,0.405,429,0.831,"tyrphostin.A9, mubritinib, NVP.TAE226, PP.121, CP.724714",0.392544976785331,0.080398976215889,FALSE +"H1650","Pearson.est","RAF inhibitor",0.67913,1.6,0.0211,286,0.262,"TAK.632, GDC.0879, regorafenib, SB.590885, AZ.628, RAF265, dabrafenib, PLX.4720, CEP.32496",1.67571754470231,0.581698708680255,FALSE +"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.29413,0.691,0.82,79,0.992,"regorafenib",0.0861861476162833,0.00348832784582135,FALSE +"H1650","Pearson.est","retinoid receptor agonist",0.5364,1.28,0.168,532,0.491,"adarotene, adapalene, fenretinide, AM.580, bexarotene",0.774690718274137,0.308918507877032,FALSE +"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.57151,1.36,0.126,554,0.482,"clofarabine, LY2334737, fludarabine.phosphate, pentostatin, triapine, fludarabine, hydroxyurea, gemcitabine",0.899629454882437,0.31695296176115,FALSE +"H1650","Pearson.est","serotonin receptor agonist",0.46256,1.1,0.317,1,0.76,"aripiprazole",0.498940737782249,0.119186407719209,FALSE +"H1650","Pearson.est","serotonin receptor antagonist",0.55302,1.33,0.141,422,0.434,"aripiprazole, SB.200646, sertindole, pirenperone, lurasidone, lerisetron",0.85078088734462,0.362510270487489,FALSE +"H1650","Pearson.est","sodium channel blocker",0.43239,1.02,0.432,653,0.82,"brivaracetam, benzethonium, lappaconite, cibenzoline, butamben, mexiletine, triamterene, ajmaline, quinidine, mepivacaine",0.364516253185088,0.0861861476162833,FALSE +"H1650","Pearson.est","src inhibitor",-0.58628,-1.67,0.0319,1407,0.29,"ZM.306416, saracatinib, dasatinib",1.49620931694282,0.537602002101044,FALSE +"H1650","Pearson.est","sterol demethylase inhibitor",-0.44502,-1.3,0.162,1275,0.542,"sulconazole, ketoconazole, terconazole, lanoconazole",0.790484985457369,0.266000713461613,FALSE +"H1650","Pearson.est","TGF beta receptor inhibitor",-0.44969,-1.22,0.217,1188,0.561,"LY2109761, SB.431542, repsox",0.66354026615147,0.251037138743839,FALSE +"H1650","Pearson.est","thymidylate synthase inhibitor",0.56056,1.31,0.141,371,0.451,"doxifluridine, raltitrexed, trifluridine, carmofur",0.85078088734462,0.345823458122039,FALSE +"H1650","Pearson.est","topoisomerase inhibitor",0.64315,1.49,0.0688,397,0.294,"doxorubicin, valrubicin, epirubicin, teniposide, voreloxin, amsacrine, daunorubicin, dexrazoxane, etoposide.phosphate, etoposide, mitoxantrone, idarubicin, topotecan, nemorubicin, TAS.103, amonafide, genz.644282, SN.38, irinotecan, exatecan.mesylate",1.16241156176449,0.531652669587843,FALSE +"H1650","Pearson.est","tubulin polymerization inhibitor",0.70647,1.68,0.0145,363,0.29,"fosbretabulin, taltobulin, vinorelbine, vindesine, KX2.391, fenbendazole, parbendazole, albendazole, vincristine, nocodazole, vinblastine, flubendazole, ABT.751, paclitaxel, verubulin, BNC105, indibulin, combretastatin.A.4, dolastatin.10, plinabulin, CYT.997, epothilone.b, docetaxel, oxibendazole",1.83863199776503,0.537602002101044,FALSE +"H1650","Pearson.est","tyrosine kinase inhibitor",0.34384,0.816,0.695,478,0.989,"regorafenib, UNC2250, tivantinib, tyrphostin.A9, mubritinib, NVP.TAE226, PP.121, bafetinib, tyrphostin.AG.99, CP.724714, GTP.14564, sorafenib, aminopurvalanol.a",0.158015195409886,0.0048037084028206,FALSE +"H1650","Pearson.est","VEGFR inhibitor",0.26944,0.644,0.907,419,0.981,"OSI.930, dovitinib, regorafenib, RAF265, axitinib, pazopanib, semaxanib, nintedanib, PD.173074, SAR131675, ENMD.2076",0.0423927129399047,0.0083309926200515,FALSE +"H1650","Pearson.est","vitamin D receptor agonist",-0.72905,-2.08,0,1156,0.095,"ercalcitriol, maxacalcitol, alfacalcidol, paricalcitol, doxercalciferol",Inf,1.02227639471115,TRUE +"H1975","Pearson.est","EGFR inhibitor",0.82838,2.01,0,88,0.0404,"poziotinib, afatinib, AZD8931, neratinib, tucatinib, dacomitinib, canertinib, osimertinib, BMS.690514, pelitinib, CUDC.101, lapatinib, CP.724714, ARRY.334543, BMS.599626, AST.1306, BIBX.1382, AEE788, gefitinib, erlotinib, rociletinib, TAK.285, XL.647, CNX.2006, PD.168393, GW.583340, WZ.4002",Inf,1.3936186348894,TRUE +"H1975","Pearson.est","Abl kinase inhibitor",0.28732,0.729,0.769,257,1,"ZM.306416, bosutinib, imatinib",0.114073660198569,0,FALSE +"H1975","Pearson.est","acetylcholine receptor agonist",-0.46045,-1.21,0.237,1252,0.556,"nefiracetam, nicotine",0.625251653989896,0.254925208417942,FALSE +"H1975","Pearson.est","acetylcholine receptor antagonist",-0.66193,-1.68,0.0393,1067,0.176,"hyoscyamine, methscopolamine, iododexetimide, dicycloverine",1.40560744962457,0.75448733218585,TRUE +"H1975","Pearson.est","adenosine receptor antagonist",0.57734,1.42,0.116,224,0.361,"CGS.15943, MRS.1220, SCH.58261",0.935542010773082,0.442492798094342,FALSE +"H1975","Pearson.est","adrenergic receptor agonist",0.18387,0.475,0.988,272,1,"lidamidine, metaraminol, A61603",0.00524305541237188,0,FALSE +"H1975","Pearson.est","adrenergic receptor antagonist",-0.36797,-0.946,0.518,1377,0.709,"metoprolol, atenolol...., levobunolol",0.285670240254767,0.149353764816933,FALSE +"H1975","Pearson.est","AKT inhibitor",0.5968,1.47,0.0917,313,0.366,"uprosertib, GDC.0068, A.674563, triciribine, CCT128930, GSK2110183, AZD5363",1.03763066432998,0.436518914605589,FALSE +"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.33128,0.82,0.668,477,0.959,"AZD3463, crizotinib, AP26113, NVP.TAE684, brigatinib, SB.505124, CEP.37440",0.175223537524454,0.0181813928293364,FALSE +"H1975","Pearson.est","androgen receptor antagonist",-0.6156,-1.6,0.0763,1086,0.234,"cyproterone.acetate, flutamide, nilutamide, bicalutamide",1.11747546204512,0.630784142589857,FALSE +"H1975","Pearson.est","antioxidant",-0.75324,-1.96,0.0118,1089,0.0679,"chlorogenic.acid, taurine, mesna, benfotiamine, trolox",1.92811799269387,1.1681302257195,TRUE +"H1975","Pearson.est","AP inhibitor",-0.47985,-1.24,0.227,1131,0.543,"embelin, idronoxil, LCL.161, GDC.0152",0.643974142806877,0.265200170411153,FALSE +"H1975","Pearson.est","ATPase inhibitor",0.24677,0.609,0.915,90,1,"k.strophanthidin, NMS.873",0.0385789059335517,0,FALSE +"H1975","Pearson.est","Aurora kinase inhibitor",0.59561,1.5,0.0872,397,0.383,"PHA.680632, TAK.901, danusertib, aurora.a.inhibitor.i, CCT137690, barasertib, CCT129202, GSK1070916, ENMD.2076, CYC116, barasertib.HQPA, ZM.447439",1.05948351506743,0.416801226031377,FALSE +"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.371,0.942,0.504,370,0.905,"azithromycin, azalomycin.b, tedizolid",0.297569463554475,0.0433514207947967,FALSE +"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.26078,-0.674,0.858,1345,0.899,"sparfloxacin",0.0665127121512946,0.0462403082667712,FALSE +"H1975","Pearson.est","BCL inhibitor",-0.29114,-0.744,0.759,1082,0.88,"ABT.737, gossypol, venetoclax",0.11975822410452,0.0555173278498314,FALSE +"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.40485,-1.04,0.411,1205,0.688,"dasatinib, flumatinib, nilotinib, ponatinib",0.386158178123931,0.162411561764489,FALSE +"H1975","Pearson.est","benzodiazepine receptor agonist",-0.32425,-0.847,0.619,1252,0.825,"nefiracetam, CGS.20625, lorazepam",0.208309350979882,0.0835460514500749,FALSE +"H1975","Pearson.est","bromodomain inhibitor",0.80793,2.02,0.00189,151,0.0739,"I.BET151, OTX015, JQ1...., PFI.1",2.72353819582676,1.13135556160517,TRUE +"H1975","Pearson.est","calcium channel blocker",0.35786,0.895,0.574,268,0.907,"SR.33805, tetrandrine, fendiline",0.241088107602027,0.0423927129399047,FALSE +"H1975","Pearson.est","CC chemokine receptor antagonist",0.48945,1.19,0.266,518,0.669,"ZK811752, RS.504393, PF.04136309, SB.225002, UNBS.5162",0.575118363368933,0.174573882232177,FALSE +"H1975","Pearson.est","CDK inhibitor",0.34675,0.874,0.604,299,0.887,"indisulam, arcyriaflavin.a, BMS.387032, aminopurvalanol.a, PHA.793887, AT.7519, TG.02",0.218963061378868,0.0520763801682736,FALSE +"H1975","Pearson.est","CHK inhibitor",0.27227,0.685,0.863,347,1,"PF.477736, CHIR.124, SB.218078",0.0639892042847904,0,FALSE +"H1975","Pearson.est","cyclooxygenase inhibitor",0.23137,0.579,0.942,430,1,"ramifenazone, phenazone, pterostilbene, FR.122047, tryptanthrin, amfenac, AM.404, aspirin, meloxicam",0.0259490972071227,0,FALSE +"H1975","Pearson.est","cytochrome P450 inhibitor",-0.79362,-2.02,0.00444,1229,0.0606,"PF.4981517, cobicistat, morin, clotrimazole, eplerenone, metyrapone",2.35261702988538,1.21752737583371,TRUE +"H1975","Pearson.est","DNA alkylating agent",0.28129,0.697,0.839,204,1,"dacarbazine, mitomycin.c, satraplatin, estramustine",0.0762380391712997,0,FALSE +"H1975","Pearson.est","DNA inhibitor",-0.36787,-0.965,0.5,1163,0.732,"metronidazole, sangivamycin, pibenzimol, carmustine, carboplatin",0.301029995663981,0.135488918941608,FALSE +"H1975","Pearson.est","DNA methyltransferase inhibitor",0.64463,1.59,0.0548,175,0.341,"SGI.1027, decitabine, fdcyd, azacitidine",1.26121944151563,0.467245621007502,FALSE +"H1975","Pearson.est","DNA polymerase inhibitor",0.40126,0.981,0.472,128,0.893,"cephalomannine, cidofovir",0.326058001365912,0.0491485411114536,FALSE +"H1975","Pearson.est","DNA synthesis inhibitor",-0.29204,-0.756,0.723,926,0.888,"cyclocytidine, capecitabine, cisplatin, artesunate, artemisinin, azodicarbonamide, CB.10.277, estramustine.phosphate, altretamine, nelarabine",0.140861702705469,0.051587034221399,FALSE +"H1975","Pearson.est","dopamine receptor antagonist",-0.38458,-0.998,0.427,1143,0.702,"nemonapride, UH.232...., paliperidone, isofloxythepin, amisulpride, raclopride",0.369572124974976,0.153662887870195,FALSE +"H1975","Pearson.est","estrogen receptor agonist",-0.42262,-1.05,0.359,1038,0.703,"equol, PPT, estradiol.cypionate, estradiol",0.444905551421681,0.153044674980176,FALSE +"H1975","Pearson.est","estrogen receptor antagonist",0.37583,0.937,0.524,515,0.882,"clomifene, tamoxifen, danazol",0.280668713016273,0.0545314148681803,FALSE +"H1975","Pearson.est","FGFR inhibitor",-0.19439,-0.49,0.971,976,0.983,"MK.2461, AZD4547, erdafitinib, orantinib",0.0127807700919951,0.00744648216786438,FALSE +"H1975","Pearson.est","FLT3 inhibitor",0.24811,0.617,0.91,442,1,"pacritinib, sorafenib, TG.02, ENMD.2076, lestaurtinib, tyrphostin.AG.1296, dovitinib",0.0409586076789064,0,FALSE +"H1975","Pearson.est","glucocorticoid receptor agonist",-0.26524,-0.68,0.834,1161,0.918,"flumethasone.pivalate, prednisolone.hemisuccinate, dexamethasone.acetate, hydrocortisone, fluocinolone.acetonide, fluticasone.propionate, piretanide",0.0788339493622613,0.0371573187987575,FALSE +"H1975","Pearson.est","glutamate receptor antagonist",0.13612,0.337,1,558,1,"CGP.37849, tiletamine, ACDPP, felbamate, LY456236, CPP",0,0,FALSE +"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.52838,-1.34,0.172,1316,0.494,"CHIR.99021, tideglusib, CHIR.98014",0.764471553092451,0.306273051076353,FALSE +"H1975","Pearson.est","growth factor receptor inhibitor",0.58961,1.48,0.105,474,0.384,"danusertib, AZD3463, lestaurtinib, GSK1838705A, GW.441756",0.978810700930062,0.415668775632469,FALSE +"H1975","Pearson.est","HCV inhibitor",-0.30711,-0.791,0.727,1131,0.893,"embelin, Ro.9187",0.138465589140962,0.0491485411114536,FALSE +"H1975","Pearson.est","HDAC inhibitor",0.65305,1.65,0.0335,373,0.281,"PCI.24781, SB.939, givinostat, M.344, trichostatin.a, vorinostat, AR.42, scriptaid, R306465, chidamide, JNJ.26481585, dacinostat, pyroxamide, belinostat, tacedinaline, NSC.3852, resminostat, panobinostat",1.47495519296315,0.55129368009492,FALSE +"H1975","Pearson.est","histamine receptor antagonist",-0.20588,-0.539,0.964,977,0.992,"ICI.162846, famotidine, pheniramine, cimetidine, tiotidine, BF2.649, nizatidine, chloropyramine, lafutidine",0.0159229660971692,0.00348832784582135,FALSE +"H1975","Pearson.est","HMGCR inhibitor",-0.88112,-2.35,0,1303,0,"simvastatin, atorvastatin, fluvastatin, mevastatin, pitavastatin",Inf,Inf,TRUE +"H1975","Pearson.est","HSP inhibitor",0.58885,1.42,0.12,250,0.361,"tanespimycin, KW.2478, BIIB021, VER.49009, alvespimycin",0.920818753952375,0.442492798094342,FALSE +"H1975","Pearson.est","JAK inhibitor",0.39335,0.957,0.488,628,0.907,"LY2784544, pacritinib, CEP.33779, TG.02, WHI.P154, lestaurtinib, AZD1480, TG.101348, baricitinib, ruxolitinib, PRT062070, TG.101209",0.311580177997289,0.0423927129399047,FALSE +"H1975","Pearson.est","KIT inhibitor",0.19981,0.493,0.976,257,1,"OSI.930, sorafenib, imatinib",0.0105501823333082,0,FALSE +"H1975","Pearson.est","MDM inhibitor",-0.73553,-1.88,0.0166,1348,0.0806,"CGM097, nutlin.3, AMG.232, idasanutlin",1.77989191195995,1.09366495819491,TRUE +"H1975","Pearson.est","MEK inhibitor",0.20079,0.492,0.985,653,1,"PD.198306, PD.98059, PD.0325901, trametinib, TAK.733, Ro.4987655, MEK162, AS.703026, AZD8330, selumetinib, MEK1.2.inhibitor, PD.184352",0.00656376950238827,0,FALSE +"H1975","Pearson.est","MET inhibitor",0.46069,1.12,0.326,316,0.74,"INC.280, NVP.BVU972, AMG458",0.486782399932061,0.130768280269024,FALSE +"H1975","Pearson.est","microtubule inhibitor",-0.29117,-0.738,0.759,1159,0.861,"vinblastine, estramustine.phosphate, secnidazole",0.11975822410452,0.0649968485463452,FALSE +"H1975","Pearson.est","mTOR inhibitor",0.19739,0.482,0.974,555,1,"GSK2126458, PF.05212384, PKI.179, AZD8055, sirolimus, torin.2, PI.103, everolimus, voxtalisib, WYE.125132, PP242, deforolimus, GDC.0980, PF.04691502",0.0114410431213845,0,FALSE +"H1975","Pearson.est","NFkB pathway inhibitor",0.24686,0.62,0.9,505,1,"EVP4593, Ro.106.9920, parthenolide...., bindarit, tyloxapol",0.0457574905606751,0,FALSE +"H1975","Pearson.est","opioid receptor agonist",-0.66214,-1.7,0.0278,1217,0.211,"spiradoline, BW.180C, cebranopadol",1.55595520408192,0.675717544702307,TRUE +"H1975","Pearson.est","p38 MAPK inhibitor",0.62102,1.53,0.0585,339,0.368,"talmapimod, SB.239063, SB.242235, TAK.715",1.23284413391782,0.434152181326482,FALSE +"H1975","Pearson.est","PARP inhibitor",0.3551,0.877,0.61,193,0.912,"PJ.34, niraparib",0.214670164989233,0.0400051616715838,FALSE +"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.34107,-0.884,0.605,1093,0.789,"telatinib, pazopanib, dasatinib, ponatinib, orantinib, KI.8751, SU014813, CP.673451",0.218244625347531,0.10292299679058,FALSE +"H1975","Pearson.est","phosphatase inhibitor",-0.50199,-1.29,0.192,1360,0.538,"bis.maltolato.oxovanadium.IV., BVT.948, GSK2830371",0.71669877129645,0.269217724333611,FALSE +"H1975","Pearson.est","phosphodiesterase inhibitor",-0.41842,-1.08,0.363,1299,0.68,"YM.976, anagrelide, GSK256066",0.440093374963888,0.167491087293764,FALSE +"H1975","Pearson.est","PI3K inhibitor",0.40705,1.01,0.426,221,0.866,"taselisib, alpelisib, CH5132799, CUDC.907, GSK2126458, PF.05212384, PIK.75, GDC.0941",0.370590400897281,0.0624821079826534,FALSE +"H1975","Pearson.est","PLK inhibitor",0.75172,1.87,0.0054,201,0.0698,"BI.2536, NMS.1286937, HMN.214, volasertib",2.26760624017703,1.15614457737684,TRUE +"H1975","Pearson.est","potassium channel blocker",-0.63988,-1.68,0.035,1233,0.176,"ibutilide, meglitinide, mepivacaine",1.45593195564972,0.75448733218585,TRUE +"H1975","Pearson.est","PPAR receptor agonist",-0.36532,-0.949,0.513,1314,0.732,"clofibrate, fenofibrate",0.289882634888184,0.135488918941608,FALSE +"H1975","Pearson.est","progesterone receptor agonist",-0.52475,-1.39,0.131,1202,0.498,"norgestrel, norethindrone.acetate, norethindrone",0.882728704344236,0.302770657240282,FALSE +"H1975","Pearson.est","proteasome inhibitor",-0.48543,-1.28,0.181,1048,0.515,"bortezomib, ixazomib, MG.132, oprozomib, ixazomib.citrate",0.742321425130815,0.288192770958809,FALSE +"H1975","Pearson.est","protein synthesis inhibitor",0.52566,1.28,0.199,216,0.532,"bruceantin, anguidine, homoharringtonine, thiostrepton, tedizolid.phosphate, puromycin, clofoctol, cycloheximide",0.701146923590293,0.274088367704952,FALSE +"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.77353,1.91,0.00678,228,0.0825,"CP.724714, BMS.599626, AV.412, tyrphostin.A9, mubritinib, NVP.TAE226",2.16877030613294,1.08354605145007,TRUE +"H1975","Pearson.est","RAF inhibitor",-0.4286,-1.11,0.329,1265,0.66,"LGX818, dabrafenib, vemurafenib",0.482804102050026,0.180456064458131,FALSE +"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.45105,1.1,0.346,202,0.746,"vandetanib, sorafenib",0.460923901207223,0.127261172527331,FALSE +"H1975","Pearson.est","retinoid receptor agonist",0.59722,1.45,0.111,341,0.37,"adarotene, tamibarotene, fenretinide, CD.437, bexarotene, adapalene",0.954677021213343,0.431798275933005,FALSE +"H1975","Pearson.est","ribonucleotide reductase inhibitor",-0.52379,-1.34,0.173,937,0.494,"fludarabine, pentostatin, cytarabine, gemcitabine, hydroxyurea, triapine, clofarabine, cladribine",0.761953896871205,0.306273051076353,FALSE +"H1975","Pearson.est","serotonin receptor agonist",-0.72293,-1.92,0.00939,1407,0.0748,"ipsapirone, SR.57227A",2.02733440773389,1.12609840213554,TRUE +"H1975","Pearson.est","serotonin receptor antagonist",0.28969,0.707,0.809,223,1,"SB.200646, lurasidone, SB.228357",0.0920514783877277,0,FALSE +"H1975","Pearson.est","sodium channel blocker",-0.3868,-1,0.421,1187,0.729,"quinidine, mepivacaine, butamben, cibenzoline, oxcarbazepine",0.375717904164332,0.137272471682025,FALSE +"H1975","Pearson.est","src inhibitor",0.45394,1.14,0.303,303,0.736,"ZM.306416, saracatinib, bosutinib, KX2.391",0.518557371497695,0.133122185662501,FALSE +"H1975","Pearson.est","sterol demethylase inhibitor",-0.43594,-1.13,0.323,1085,0.66,"ketoconazole, terconazole, sulconazole",0.490797477668897,0.180456064458131,FALSE +"H1975","Pearson.est","TGF beta receptor inhibitor",-0.29958,-0.781,0.702,432,0.879,"repsox, D.4476, SB.431542, adaprev, SB.525334, LY2109761",0.153662887870195,0.0560111249262281,FALSE +"H1975","Pearson.est","thymidylate synthase inhibitor",0.28988,0.725,0.804,1030,1,"carmofur, raltitrexed, trifluridine, doxifluridine, capecitabine, ftorafur",0.0947439512515487,0,FALSE +"H1975","Pearson.est","topoisomerase inhibitor",0.42143,1.06,0.357,499,0.799,"amonafide, exatecan.mesylate, camptothecin, irinotecan, amsacrine, genz.644282, valrubicin, mitoxantrone, SN.38, idarubicin, teniposide, daunorubicin, doxorubicin",0.447331783887807,0.0974532206860086,FALSE +"H1975","Pearson.est","tubulin polymerization inhibitor",0.54913,1.38,0.12,317,0.397,"nocodazole, albendazole, fosbretabulin, parbendazole, fenbendazole, plinabulin, indibulin, paclitaxel, vinorelbine, mebendazole, vincristine, KX2.391, docetaxel, dolastatin.10, oxibendazole",0.920818753952375,0.401209493236885,FALSE +"H1975","Pearson.est","tyrosine kinase inhibitor",0.61601,1.53,0.0929,228,0.368,"CP.724714, BMS.599626, AV.412, tivantinib, tyrphostin.A9, mubritinib, vandetanib, aminopurvalanol.a, sorafenib, NVP.TAE226",1.03198428600636,0.434152181326482,FALSE +"H1975","Pearson.est","VEGFR inhibitor",0.36187,0.898,0.574,471,0.933,"BMS.690514, AEE788, ZM.306416, OSI.930, XL.647, vandetanib, sorafenib, PD.173074, ENMD.2076, tivozanib, axitinib, foretinib, dovitinib, TG.100572, regorafenib, golvatinib, vatalanib",0.241088107602027,0.0301183562535,FALSE +"H1975","Pearson.est","vitamin D receptor agonist",0.75925,1.9,0.00693,264,0.0678,"maxacalcitol, tacalcitol, calcitriol, ercalcitriol, paricalcitol",2.15926676538819,1.16877030613294,TRUE +"H2009","Pearson.est","EGFR inhibitor",-0.85853,-2.14,0,1319,0.0146,"GW.583340, PD.153035, WZ8040, CUDC.101, AEE788, BIBX.1382, brigatinib, BMS.599626, WZ.4002, BIBU.1361, icotinib, AST.1306, TAK.285, CP.724714, rociletinib, PD.168393, tucatinib, gefitinib, ARRY.334543, vandetanib, lapatinib, XL.647, erlotinib, neratinib, BMS.690514, dacomitinib, osimertinib, AZD8931, pelitinib, poziotinib, canertinib, afatinib",Inf,1.83564714421556,TRUE +"H2009","Pearson.est","Abl kinase inhibitor",-0.57232,-1.37,0.147,1408,0.471,"dasatinib, ZM.306416, bosutinib",0.832682665251824,0.326979092871104,FALSE +"H2009","Pearson.est","acetylcholine receptor agonist",0.4241,1.08,0.344,75,0.69,"nefiracetam, nicotine",0.46344155742847,0.161150909262745,FALSE +"H2009","Pearson.est","acetylcholine receptor antagonist",0.68339,1.73,0.0234,409,0.194,"dicycloverine, iododexetimide, diphemanil, methscopolamine",1.63078414258986,0.712198270069774,TRUE +"H2009","Pearson.est","adenosine receptor antagonist",-0.39966,-0.982,0.462,1429,0.75,"CGS.15943",0.335358024443874,0.1249387366083,FALSE +"H2009","Pearson.est","adrenergic receptor agonist",-0.42,-1.03,0.407,1023,0.753,"metaraminol, lidamidine, A61603, clenbuterol, buphenine, epinephrine, isoxsuprine",0.39040559077478,0.123205023799299,FALSE +"H2009","Pearson.est","adrenergic receptor antagonist",-0.23291,-0.577,0.941,1010,0.955,"naftidrofuryl, imiloxan, prazosin, propranolol, dronedarone, practolol, RS.17053, pindolol",0.0264103765727431,0.0199966284162537,FALSE +"H2009","Pearson.est","AKT inhibitor",-0.39427,-0.966,0.468,1107,0.723,"CCT128930, A.674563, uprosertib, triciribine",0.329754146925876,0.140861702705469,FALSE +"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.5675,-1.42,0.13,1171,0.421,"crizotinib, GW.788388, NVP.TAE684, AZD3463, AP26113, brigatinib",0.886056647693163,0.375717904164332,FALSE +"H2009","Pearson.est","androgen receptor antagonist",0.32216,0.846,0.628,347,0.824,"nilutamide, RU.58841",0.202040356262804,0.0840727883028842,FALSE +"H2009","Pearson.est","antioxidant",0.44778,1.12,0.33,283,0.683,"trolox, taurine",0.481486060122112,0.165579296318467,FALSE +"H2009","Pearson.est","AP inhibitor",0.56126,1.44,0.113,157,0.518,"GDC.0152, idronoxil, LCL.161",0.94692155651658,0.285670240254767,FALSE +"H2009","Pearson.est","ATPase inhibitor",0.34868,0.876,0.578,112,0.857,"digoxin, blebbistatin...., oligomycin.a",0.238072161579471,0.0670191780768018,FALSE +"H2009","Pearson.est","Aurora kinase inhibitor",-0.4014,-1,0.454,972,0.777,"PF.03814735, alisertib, KW.2449, ZM.447439, CYC116, hesperadin, TAK.901, danusertib, PHA.680632, aurora.a.inhibitor.i, GSK1070916, MLN.8054",0.342944147142896,0.109578981199086,FALSE +"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.49043,-1.24,0.241,1120,0.598,"azalomycin.b, azithromycin, tedizolid",0.617982957425132,0.223298816011589,FALSE +"H2009","Pearson.est","bacterial DNA gyrase inhibitor",-0.20565,-0.505,0.977,1119,0.973,"lomefloxacin, finafloxacin",0.0101054362812269,0.0118871597316481,FALSE +"H2009","Pearson.est","BCL inhibitor",0.48647,1.24,0.248,186,0.658,"ABT.737, gossypol, TW.37",0.605548319173784,0.181774106386044,FALSE +"H2009","Pearson.est","Bcr.Abl kinase inhibitor",-0.48573,-1.17,0.276,1408,0.659,"dasatinib, bosutinib",0.559090917934782,0.18111458540599,FALSE +"H2009","Pearson.est","benzodiazepine receptor agonist",0.2133,0.544,0.963,515,0.982,"nefiracetam, lorazepam, CL.218872, zaleplon, indiplon, temazepam, eprinomectin",0.0163737128754655,0.00788851221305034,FALSE +"H2009","Pearson.est","bromodomain inhibitor",0.49086,1.23,0.228,207,0.634,"bromosporine",0.642065152999546,0.197910742118267,FALSE +"H2009","Pearson.est","calcium channel blocker",0.41574,1.06,0.389,156,0.694,"carboxyamidotriazole, mibefradil, pranidipine",0.410050398674292,0.158640529545145,FALSE +"H2009","Pearson.est","CC chemokine receptor antagonist",0.22137,0.568,0.961,1129,1,"SB.225002, UNBS.5162, PF.04136309, MK.0812, RS.504393, navarixin, ZK811752",0.0172766123314547,0,FALSE +"H2009","Pearson.est","CDK inhibitor",0.16,0.408,0.998,15,0.997,"abemaciclib",0.000869458712628891,0.00130484168834428,FALSE +"H2009","Pearson.est","CHK inhibitor",-0.44925,-1.11,0.327,979,0.67,"PF.477736, LY2606368, CHIR.124, LY2603618",0.485452247339714,0.173925197299174,FALSE +"H2009","Pearson.est","cyclooxygenase inhibitor",-0.40752,-0.995,0.445,1292,0.755,"ketoprofen, AM.404, phenazone, FK.3311, aspirin, ramifenazone",0.351639989019068,0.122053048370812,FALSE +"H2009","Pearson.est","cytochrome P450 inhibitor",0.7995,2.01,0,277,0.0619,"metyrapone, cobicistat, clotrimazole, itraconazole, eplerenone, morin",Inf,1.20830935097988,TRUE +"H2009","Pearson.est","DNA alkylating agent",0.31846,0.828,0.674,261,0.804,"carboplatin, TH.302, carmustine, temozolomide, streptozotocin, melphalan",0.17134010346468,0.0947439512515487,FALSE +"H2009","Pearson.est","DNA inhibitor",0.49624,1.3,0.186,261,0.636,"pibenzimol, carboplatin, chlorambucil, carmustine, oxaliplatin, metronidazole, melphalan",0.730487055782084,0.196542884351586,FALSE +"H2009","Pearson.est","DNA methyltransferase inhibitor",-0.4607,-1.13,0.309,1351,0.702,"azacitidine, SGI.1027, decitabine",0.510041520575165,0.153662887870195,FALSE +"H2009","Pearson.est","DNA polymerase inhibitor",-0.27401,-0.665,0.807,1397,0.941,"cephalomannine",0.0931264652779296,0.0264103765727431,FALSE +"H2009","Pearson.est","DNA synthesis inhibitor",0.34516,0.897,0.533,331,0.914,"altretamine, artesunate, nelarabine, azodicarbonamide, cyclocytidine",0.273272790973428,0.0390538042661686,FALSE +"H2009","Pearson.est","dopamine receptor antagonist",0.48243,1.21,0.267,324,0.593,"paliperidone, raclopride, nemonapride, isofloxythepin, amisulpride, remoxipride, domperidone",0.573488738635425,0.226945306635737,FALSE +"H2009","Pearson.est","estrogen receptor agonist",-0.24614,-0.609,0.904,1365,0.976,"ethinyl.estradiol",0.0438315695246367,0.0105501823333082,FALSE +"H2009","Pearson.est","estrogen receptor antagonist",0.21775,0.56,0.951,1134,0.998,"fulvestrant, danazol, toremifene, tamoxifen, raloxifene, clomifene",0.0218194830625861,0.000869458712628891,FALSE +"H2009","Pearson.est","FGFR inhibitor",0.52991,1.39,0.138,179,0.564,"erdafitinib, orantinib, dovitinib",0.860120913598763,0.248720896016658,FALSE +"H2009","Pearson.est","FLT3 inhibitor",0.33656,0.886,0.586,179,0.902,"TG.101348, GTP.14564, dovitinib",0.232102383981909,0.0447934624580583,FALSE +"H2009","Pearson.est","glucocorticoid receptor agonist",0.41901,1.09,0.363,279,0.706,"dexamethasone.acetate, piretanide, prednisolone.hemisuccinate, halcinonide, triamcinolone, fluticasone.propionate, deflazacort, flumethasone.pivalate",0.440093374963888,0.151195298948196,FALSE +"H2009","Pearson.est","glutamate receptor antagonist",0.32368,0.82,0.659,240,0.793,"MTPG, CPP, ACDPP",0.18111458540599,0.100726812682396,FALSE +"H2009","Pearson.est","glycogen synthase kinase inhibitor",0.33159,0.858,0.632,483,0.83,"CHIR.98014, GSK.3.inhibitor.IX, CHIR.99021, indirubin, TWS.119",0.199282921717615,0.0809219076239261,FALSE +"H2009","Pearson.est","growth factor receptor inhibitor",-0.59576,-1.45,0.103,1050,0.405,"lestaurtinib, GSK1838705A, danusertib, AZD3463",0.987162775294828,0.392544976785331,FALSE +"H2009","Pearson.est","HCV inhibitor",0.47552,1.22,0.234,117,0.613,"Ro.9187, mericitabine",0.630784142589857,0.212539525481585,FALSE +"H2009","Pearson.est","HDAC inhibitor",-0.5424,-1.34,0.155,1134,0.487,"givinostat, chidamide, AR.42, belinostat, tacedinaline, PCI.24781, SB.939, trichostatin.a, vorinostat, panobinostat, JNJ.26481585",0.809668301829709,0.312471038785366,FALSE +"H2009","Pearson.est","histamine receptor antagonist",-0.34167,-0.849,0.622,1284,0.844,"levocetirizine, terfenadine, ranitidine, ebastine, zolantidine",0.206209615309181,0.073657553374345,FALSE +"H2009","Pearson.est","HMGCR inhibitor",0.7293,1.82,0.0155,258,0.151,"mevastatin, fluvastatin, atorvastatin, pitavastatin",1.80966830182971,0.821023052706831,TRUE +"H2009","Pearson.est","HSP inhibitor",-0.6319,-1.58,0.0557,1002,0.307,"guanidine, SNX.2112, ganetespib, NVP.AUY922, SNX.5422, XL888, alvespimycin, PU.H71, KW.2478, tanespimycin, BIIB021, VER.49009",1.25414480482627,0.512861624522813,FALSE +"H2009","Pearson.est","JAK inhibitor",-0.45301,-1.12,0.318,1214,0.686,"AZD1480, WHI.P154, LY2784544, ruxolitinib, CEP.33779",0.497572880015567,0.163675884293248,FALSE +"H2009","Pearson.est","KIT inhibitor",0.25702,0.655,0.864,383,0.958,"pazopanib, cediranib, KI.8751, telatinib, motesanib, sunitinib",0.0634862575211067,0.0186344909214556,FALSE +"H2009","Pearson.est","MDM inhibitor",0.82381,2.12,0,97,0.0387,"idasanutlin, AMG.232, nutlin.3, CGM097",Inf,1.41228903498109,TRUE +"H2009","Pearson.est","MEK inhibitor",-0.37827,-0.9,0.538,913,0.812,"PD.0325901, PD.198306, AS.703026, refametinib, MEK1.2.inhibitor, trametinib, PD.184352, AZD8330, PD.98059, TAK.733, Ro.4987655",0.269217724333611,0.0904439707588247,FALSE +"H2009","Pearson.est","MET inhibitor",-0.71592,-1.74,0.0206,1361,0.189,"LY2801653, INC.280",1.68613277963085,0.723538195826756,TRUE +"H2009","Pearson.est","microtubule inhibitor",-0.28182,-0.683,0.825,939,0.969,"colchicine, cytochalasin.b, D.64131, podophyllotoxin, cabazitaxel",0.0835460514500749,0.0136762229492347,FALSE +"H2009","Pearson.est","mTOR inhibitor",-0.24386,-0.596,0.904,1158,0.963,"torin.2, deforolimus, everolimus, AZD8055, temsirolimus, GSK2126458, PF.05212384, sirolimus",0.0438315695246367,0.0163737128754655,FALSE +"H2009","Pearson.est","NFkB pathway inhibitor",0.47912,1.25,0.229,299,0.688,"tyloxapol, BAY.11.7082, betulinic.acid, parthenolide...., parthenolide",0.640164517660112,0.162411561764489,FALSE +"H2009","Pearson.est","opioid receptor agonist",0.33533,0.865,0.6,190,0.847,"cebranopadol, BW.180C",0.221848749616356,0.0721165896692931,FALSE +"H2009","Pearson.est","p38 MAPK inhibitor",-0.68503,-1.66,0.0265,1208,0.264,"CMPD.1, SB.242235, TAK.715, SB.239063, talmapimod",1.57675412606319,0.578396073130169,FALSE +"H2009","Pearson.est","PARP inhibitor",0.25625,0.665,0.857,1079,0.972,"AG.14361, endo.IWR.1, AZD2461, E7449, olaparib, niraparib, talazoparib, PJ.34",0.0670191780768018,0.0123337350737254,FALSE +"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.3746,0.97,0.491,508,0.803,"pazopanib, orantinib, SU014813, dovitinib, linifanib, KI.8751, axitinib, telatinib, motesanib, sunitinib, ponatinib, CP.673451, regorafenib, lenvatinib",0.308918507877032,0.095284454721319,FALSE +"H2009","Pearson.est","phosphatase inhibitor",0.57569,1.45,0.0917,92,0.56,"GSK2830371, menadione, bis.maltolato.oxovanadium.IV.",1.03763066432998,0.2518119729938,FALSE +"H2009","Pearson.est","phosphodiesterase inhibitor",-0.29278,-0.72,0.8,1317,0.945,"EMD.53998, papaverine",0.0969100130080564,0.0245681914907371,FALSE +"H2009","Pearson.est","PI3K inhibitor",-0.27893,-0.679,0.823,1121,0.948,"PIK.75, CUDC.907, GDC.0941, GSK2126458, PF.05212384, PI.828, TG.100713, CH5132799, taselisib, alpelisib",0.0846001647877302,0.0231916626619338,FALSE +"H2009","Pearson.est","PLK inhibitor",-0.72235,-1.77,0.0288,1373,0.188,"HMN.214, BI.2536, NMS.1286937",1.54060751224077,0.72584215073632,TRUE +"H2009","Pearson.est","potassium channel blocker",0.3229,0.845,0.616,113,0.8,"mepivacaine",0.210419287835575,0.0969100130080564,FALSE +"H2009","Pearson.est","PPAR receptor agonist",0.66616,1.68,0.0393,104,0.22,"clofibrate, fenofibrate, GW.501516",1.40560744962457,0.657577319177794,TRUE +"H2009","Pearson.est","progesterone receptor agonist",0.40932,1.04,0.403,356,0.701,"norethindrone, norethindrone.acetate, norgestrel, tanaproget",0.39469495385889,0.154281982033341,FALSE +"H2009","Pearson.est","proteasome inhibitor",-0.29843,-0.735,0.784,1097,0.979,"ONX.0914, ixazomib, carfilzomib, delanzomib",0.105683937315562,0.00921730819686218,FALSE +"H2009","Pearson.est","protein synthesis inhibitor",-0.36018,-0.894,0.583,1074,0.796,"emetine, thiostrepton, bruceantin, tedizolid.phosphate, homoharringtonine, cycloheximide, puromycin",0.234331445240986,0.0990869322623309,FALSE +"H2009","Pearson.est","protein tyrosine kinase inhibitor",-0.81453,-1.97,0.00172,1321,0.0586,"tyrphostin.A9, NVP.TAE226, BMS.599626, CP.724714, AV.412",2.76447155309245,1.23210238398191,TRUE +"H2009","Pearson.est","RAF inhibitor",0.77208,2,0.00236,60,0.0449,"dabrafenib, vemurafenib, SB.590885, AZ.628, TAK.632",2.62708799702989,1.34775365899668,TRUE +"H2009","Pearson.est","RET tyrosine kinase inhibitor",-0.62262,-1.53,0.0694,1431,0.348,"vandetanib",1.15864052954514,0.458420756053419,FALSE +"H2009","Pearson.est","retinoid receptor agonist",-0.43973,-1.05,0.406,1186,0.751,"tamibarotene, CD.437, adarotene",0.391473966422806,0.124360062995832,FALSE +"H2009","Pearson.est","ribonucleotide reductase inhibitor",0.70612,1.79,0.0133,355,0.15,"cladribine, pentostatin, triapine, hydroxyurea, clofarabine, cytarabine, fludarabine",1.87614835903291,0.823908740944319,TRUE +"H2009","Pearson.est","serotonin receptor agonist",0.51619,1.36,0.137,544,0.57,"aripiprazole, NAN.190, zolmitriptan, SR.57227A, ipsapirone",0.863279432843593,0.244125144327509,FALSE +"H2009","Pearson.est","serotonin receptor antagonist",0.33329,0.881,0.572,161,0.879,"lerisetron, paliperidone, aripiprazole",0.242603971206976,0.0560111249262281,FALSE +"H2009","Pearson.est","sodium channel blocker",0.4611,1.2,0.266,321,0.577,"cibenzoline, benzethonium, butamben, mepivacaine, oxcarbazepine, quinidine, mexiletine",0.575118363368933,0.238824186844269,FALSE +"H2009","Pearson.est","src inhibitor",-0.75769,-1.84,0.00525,1408,0.149,"dasatinib, ZM.306416, bosutinib, saracatinib",2.27984069659404,0.826813731587726,TRUE +"H2009","Pearson.est","sterol demethylase inhibitor",-0.34066,-0.846,0.641,1385,0.823,"lanoconazole",0.193141970481183,0.0846001647877302,FALSE +"H2009","Pearson.est","TGF beta receptor inhibitor",-0.50408,-1.22,0.233,1166,0.6,"SB.431542, D.4476, repsox",0.632644078973981,0.221848749616356,FALSE +"H2009","Pearson.est","thymidylate synthase inhibitor",0.27182,0.704,0.806,398,0.947,"ftorafur, doxifluridine, trifluridine",0.0936649581949093,0.0236500209967266,FALSE +"H2009","Pearson.est","topoisomerase inhibitor",-0.29219,-0.728,0.773,1006,0.961,"rubitecan, licochalcone.a, fleroxacin, mitoxantrone, irinotecan, amonafide, SN.38, genz.644282, camptothecin, exatecan.mesylate",0.111820506081675,0.0172766123314547,FALSE +"H2009","Pearson.est","tubulin polymerization inhibitor",-0.50291,-1.24,0.226,1118,0.598,"epothilone.d, dolastatin.10, fenbendazole, fosbretabulin, podophyllotoxin, indibulin, epothilone.b, nocodazole, parbendazole, plinabulin, paclitaxel, docetaxel, mebendazole",0.645891560852599,0.223298816011589,FALSE +"H2009","Pearson.est","tyrosine kinase inhibitor",-0.65417,-1.65,0.0521,1321,0.24,"tyrphostin.A9, NVP.TAE226, aminopurvalanol.a, BMS.599626, dasatinib, tivantinib, CP.724714, vandetanib, AV.412",1.28316227670048,0.619788758288394,FALSE +"H2009","Pearson.est","VEGFR inhibitor",-0.39278,-0.972,0.45,1379,0.739,"AEE788, ZM.306416, vandetanib, XL.647, BMS.690514",0.346787486224656,0.131355561605174,FALSE +"H2009","Pearson.est","vitamin D receptor agonist",-0.58912,-1.45,0.0963,1196,0.405,"calcitriol, ercalcitriol, maxacalcitol",1.01637371287547,0.392544976785331,FALSE +"H2126","Pearson.est","EGFR inhibitor",-0.49026,-1.36,0.142,1291,0.285,"poziotinib, AZD8931, lapatinib, dacomitinib, CP.724714, osimertinib, AST.1306, WZ.4002, PD.153035, WZ8040, PD.168393, BIBU.1361, tucatinib, BMS.599626",0.847711655616944,0.54515513999149,FALSE +"H2126","Pearson.est","Abl kinase inhibitor",0.62316,1.51,0.0556,145,0.357,"GZD824, ponatinib, metatinib, nilotinib, tozasertib, KW.2449",1.25492520841794,0.447331783887807,FALSE +"H2126","Pearson.est","acetylcholine receptor agonist",0.42976,1.02,0.434,181,0.71,"xanomeline, tremorine",0.362510270487489,0.148741651280925,FALSE +"H2126","Pearson.est","acetylcholine receptor antagonist",0.37364,0.903,0.587,293,0.798,"methscopolamine, darifenacin",0.231361898752386,0.0979971086492706,FALSE +"H2126","Pearson.est","adenosine receptor antagonist",-0.66578,-1.93,0.026,1348,0.109,"SCH.58261, MRS.1220, CGS.15943",1.58502665202918,0.962573502059376,TRUE +"H2126","Pearson.est","adrenergic receptor agonist",0.35324,0.853,0.627,421,0.845,"clenbuterol, A61603, norepinephrine, terbutaline, epinephrine",0.202732459169284,0.0731432910503077,FALSE +"H2126","Pearson.est","adrenergic receptor antagonist",0.24683,0.594,0.922,220,0.96,"idazoxan, carvedilol, atenolol......",0.0352690789463706,0.0177287669604316,FALSE +"H2126","Pearson.est","AKT inhibitor",-0.51211,-1.44,0.118,1189,0.266,"GSK2110183, CCT128930, palomid.529, AZD5363, AT7867",0.928117992693875,0.575118363368933,FALSE +"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.55189,1.32,0.156,597,0.392,"alectinib, crizotinib, NVP.TAE684, DMH1, brigatinib, AP26113, GW.788388, lorlatinib",0.806875401645538,0.406713932979543,FALSE +"H2126","Pearson.est","androgen receptor antagonist",-0.59497,-1.65,0.0595,1431,0.162,"RU.58841",1.22548303427145,0.790484985457369,FALSE +"H2126","Pearson.est","antioxidant",-0.49307,-1.37,0.124,711,0.303,"taurine, rutin, benfotiamine, chlorogenic.acid, mesna, trolox",0.906578314837765,0.518557371497695,FALSE +"H2126","Pearson.est","AP inhibitor",0.3115,0.752,0.762,114,0.966,"idronoxil",0.1180450286604,0.0150228735845067,FALSE +"H2126","Pearson.est","ATPase inhibitor",0.61822,1.47,0.0727,331,0.405,"k.strophanthidin, digoxin, digitoxigenin, thonzonium, digitoxin, NMS.873, oligomycin.a, ouabain",1.13846558914096,0.392544976785331,FALSE +"H2126","Pearson.est","Aurora kinase inhibitor",0.63705,1.55,0.0444,454,0.396,"danusertib, barasertib.HQPA, barasertib, MK.5108, tozasertib, KW.2449, TAK.901, GSK1070916, AMG900, MK.8745, hesperadin, alisertib, PF.03814735, SNS.314, ENMD.2076, CCT137690, AT.9283, aurora.a.inhibitor.i, PHA.680632",1.35261702988538,0.402304814074488,FALSE +"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.30824,0.745,0.781,558,0.958,"valnemulin, tedizolid, radezolid, azithromycin",0.1073489661227,0.0186344909214556,FALSE +"H2126","Pearson.est","bacterial DNA gyrase inhibitor",-0.21268,-0.592,0.946,1389,1,"nadifloxacin",0.0241088635982073,0,FALSE +"H2126","Pearson.est","BCL inhibitor",0.58705,1.41,0.0903,364,0.384,"TW.37, oridonin, gossypol",1.04431224968649,0.415668775632469,FALSE +"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.63411,1.53,0.0564,142,0.351,"GZD824, ponatinib, metatinib, nilotinib, tozasertib",1.24872089601666,0.454692883534176,FALSE +"H2126","Pearson.est","benzodiazepine receptor agonist",0.29498,0.707,0.826,4,0.918,"bentazepam",0.0830199526796178,0.0371573187987575,FALSE +"H2126","Pearson.est","bromodomain inhibitor",-0.65274,-1.74,0.0289,979,0.133,"I.BET.762, OTX015, JQ1...., I.BET151",1.53910215724345,0.876148359032914,TRUE +"H2126","Pearson.est","calcium channel blocker",-0.2597,-0.721,0.759,1210,0.927,"SR.33805, cinnarazine, fendiline",0.11975822410452,0.0329202658555029,FALSE +"H2126","Pearson.est","CC chemokine receptor antagonist",0.57285,1.38,0.127,27,0.375,"UNBS.5162",0.896196279044043,0.425968732272281,FALSE +"H2126","Pearson.est","CDK inhibitor",0.3081,0.744,0.781,537,0.94,"PHA.848125, indisulam, abemaciclib, palbociclib, alvocidib, R547, P276.00, PHA.793887, JNJ.7706621, aminopurvalanol.a, dinaciclib",0.1073489661227,0.0268721464003014,FALSE +"H2126","Pearson.est","CHK inhibitor",0.56244,1.34,0.14,369,0.39,"PF.477736, LY2606368, SCH.900776, SB.218078",0.853871964321762,0.408935392973501,FALSE +"H2126","Pearson.est","cyclooxygenase inhibitor",-0.21233,-0.591,0.935,303,0.982,"indoprofen, suxibuzone, tepoxalin, amfenac, FK.3311, AM.404, ramifenazone, sulfasalazine, meloxicam, piroxicam, curcumin, ketoprofen, pterostilbene, metoxibutropate, FR.122047, phenazone, aspirin, acetylsalicylsalicylic.acid, tryptanthrin, phenylbutazone, naproxen",0.0291883891274822,0.00788851221305034,FALSE +"H2126","Pearson.est","cytochrome P450 inhibitor",-0.29632,-0.802,0.68,427,0.838,"PF.4981517, cobicistat, morin, metyrapone, clotrimazole, itraconazole, eplerenone",0.167491087293764,0.0767559813697235,FALSE +"H2126","Pearson.est","DNA alkylating agent",0.55048,1.34,0.145,351,0.39,"cisplatin, dianhydrogalactitol, carmustine, estramustine, melphalan, satraplatin",0.838631997765025,0.408935392973501,FALSE +"H2126","Pearson.est","DNA inhibitor",0.25614,0.621,0.921,251,0.955,"chlorambucil, valrubicin, carmustine, melphalan",0.0357403698031511,0.0199966284162537,FALSE +"H2126","Pearson.est","DNA methyltransferase inhibitor",0.41384,0.995,0.459,51,0.739,"disulfiram",0.338187314462739,0.131355561605174,FALSE +"H2126","Pearson.est","DNA polymerase inhibitor",0.26623,0.64,0.905,126,0.955,"cephalomannine",0.0433514207947967,0.0199966284162537,FALSE +"H2126","Pearson.est","DNA synthesis inhibitor",0.47255,1.14,0.313,559,0.565,"cisplatin, artemisinin, floxuridine, altretamine, cyclocytidine, capecitabine, enocitabine, anisomycin, mitomycin.c",0.504455662453552,0.247951552180562,FALSE +"H2126","Pearson.est","dopamine receptor antagonist",-0.57258,-1.61,0.065,1307,0.164,"piperacetazine, nemonapride, thioproperazine, acetophenazine, clebopride, oxiperomide, remoxipride",1.18708664335714,0.785156151952302,FALSE +"H2126","Pearson.est","estrogen receptor agonist",0.19794,0.479,0.982,695,0.984,"PPT, ethinyl.estradiol, estradiol, estradiol.cypionate",0.00788851221305034,0.00700490156865849,FALSE +"H2126","Pearson.est","estrogen receptor antagonist",-0.32008,-0.872,0.556,1148,0.761,"clomifene, raloxifene, tamoxifen",0.254925208417942,0.118615343229427,FALSE +"H2126","Pearson.est","FGFR inhibitor",0.51763,1.23,0.215,324,0.449,"erdafitinib, dovitinib, regorafenib, MK.2461, lenvatinib",0.667561540084395,0.347753658996677,FALSE +"H2126","Pearson.est","FLT3 inhibitor",0.52035,1.24,0.199,352,0.463,"dovitinib, ponatinib, tyrphostin.AG.1296, gilteritinib, tozasertib, KW.2449, lestaurtinib, midostaurin, sorafenib, ENMD.2076",0.701146923590293,0.334419008982047,FALSE +"H2126","Pearson.est","glucocorticoid receptor agonist",0.36276,0.875,0.62,507,0.827,"fluticasone.propionate, flumethasone.pivalate, betamethasone, halobetasol.propionate, difluprednate, desonide, fludroxycortide, prednisolone.hemisuccinate, ciclesonide, halcinonide, clobetasol.propionate, triamcinolone, dexamethasone.acetate, prednisolone.acetate, rimexolone",0.207608310501746,0.0824944904474534,FALSE +"H2126","Pearson.est","glutamate receptor antagonist",-0.37609,-1.06,0.357,1195,0.56,"kynurenic.acid, LY456236, JNJ.16259685, IEM1754, latrepirdine",0.447331783887807,0.2518119729938,FALSE +"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.38176,-1.03,0.39,1313,0.568,"GSK.3.inhibitor.IX, indirubin, LY2090314",0.408935392973501,0.245651664288981,FALSE +"H2126","Pearson.est","growth factor receptor inhibitor",0.53989,1.28,0.184,176,0.425,"PHA.848125, danusertib, lestaurtinib",0.735182176990464,0.371611069949688,FALSE +"H2126","Pearson.est","HCV inhibitor",0.58566,1.42,0.0936,528,0.39,"narlaprevir, mericitabine, daclatasvir, embelin, Ro.9187",1.02872415126189,0.408935392973501,FALSE +"H2126","Pearson.est","HDAC inhibitor",-0.18304,-0.496,0.988,1347,0.985,"JNJ.26481585, romidepsin, mocetinostat, RG2833",0.00524305541237188,0.00656376950238827,FALSE +"H2126","Pearson.est","histamine receptor antagonist",-0.38881,-1.1,0.324,556,0.535,"pheniramine, zolantidine, tiotidine, lafutidine, ebastine, BF2.649, famotidine, cyproheptadine, terfenadine, ICI.162846, astemizole, epinastine, cimetidine, levocetirizine, nizatidine, tecastemizole, ranitidine, chloropyramine",0.489454989793388,0.271646217978772,FALSE +"H2126","Pearson.est","HMGCR inhibitor",0.88529,2.12,0,72,0.00397,"atorvastatin, pitavastatin, fluvastatin, mevastatin",Inf,2.40120949323688,TRUE +"H2126","Pearson.est","HSP inhibitor",0.5824,1.42,0.1,206,0.39,"NMS.E973, SNX.5422, PU.H71, SNX.2112, BIIB021, ganetespib, NVP.AUY922",1,0.408935392973501,FALSE +"H2126","Pearson.est","JAK inhibitor",0.3861,0.923,0.568,425,0.799,"ruxolitinib, baricitinib, tozasertib, AZ960, lestaurtinib, WHI.P154, TG.101209, AT.9283, AZD1480",0.245651664288981,0.0974532206860086,FALSE +"H2126","Pearson.est","KIT inhibitor",0.40606,0.978,0.497,338,0.733,"pazopanib, OSI.930, regorafenib, midostaurin, dasatinib, motesanib, lenvatinib, sorafenib",0.303643611266668,0.134896025358872,FALSE +"H2126","Pearson.est","MDM inhibitor",-0.64693,-1.79,0.0272,1133,0.162,"idasanutlin, AMG.232, CGM097, RITA",1.5654310959658,0.790484985457369,TRUE +"H2126","Pearson.est","MEK inhibitor",-0.64276,-1.78,0.0226,1154,0.137,"Ro.4987655, PD.184352, refametinib, cobimetinib, AZD8330, TAK.733, nobiletin, PD.198306, trametinib, AS.703026, selumetinib",1.6458915608526,0.863279432843593,TRUE +"H2126","Pearson.est","MET inhibitor",0.46719,1.13,0.333,274,0.568,"LY2801653, PHA.665752",0.47755576649368,0.245651664288981,FALSE +"H2126","Pearson.est","microtubule inhibitor",0.63841,1.53,0.0489,335,0.351,"vinblastine, triclabendazole, D.64131, cabazitaxel, vinflunine, podophyllotoxin",1.31069114087638,0.454692883534176,FALSE +"H2126","Pearson.est","mTOR inhibitor",0.55385,1.33,0.16,413,0.39,"deforolimus, OSI.027, temsirolimus, AZD8055, PF.04691502, SB.2343, LY3023414, NVP.BEZ235, PKI.179, torin.1, everolimus, GSK2126458, AZD2014, MLN0128, PP242, sirolimus, WAY.600, torin.2",0.795880017344075,0.408935392973501,FALSE +"H2126","Pearson.est","NFkB pathway inhibitor",0.20427,0.495,0.977,586,0.996,"bindarit, EVP4593, betulinic.acid, BAY.11.7082, BAY.11.7085",0.0101054362812269,0.00174066157630127,FALSE +"H2126","Pearson.est","opioid receptor agonist",0.37936,0.913,0.579,347,0.797,"spiradoline, trimebutine",0.237321436272564,0.0985416786038876,FALSE +"H2126","Pearson.est","p38 MAPK inhibitor",0.31103,0.738,0.787,94,0.896,"talmapimod",0.104025267640935,0.0476919903378748,FALSE +"H2126","Pearson.est","PARP inhibitor",0.79064,1.9,0.00271,52,0.0709,"talazoparib, olaparib, niraparib, AZD2461",2.56703070912559,1.14935376481693,TRUE +"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.42714,1.04,0.422,338,0.69,"dovitinib, CP.673451, ponatinib, pazopanib, regorafenib, axitinib, dasatinib, motesanib, lenvatinib, sorafenib",0.374687549038326,0.161150909262745,FALSE +"H2126","Pearson.est","phosphatase inhibitor",0.38758,0.933,0.561,699,0.798,"bis.maltolato.oxovanadium.IV., sodium.stibogluconate, BVT.948, CID.5458317, mycophenolic.acid, GSK2830371, alexidine",0.251037138743839,0.0979971086492706,FALSE +"H2126","Pearson.est","phosphodiesterase inhibitor",0.50702,1.22,0.242,508,0.452,"zardaverine, GSK256066, enoximone, anagrelide, papaverine, YM.976",0.616184634019569,0.344861565188618,FALSE +"H2126","Pearson.est","PI3K inhibitor",0.52189,1.27,0.181,260,0.426,"buparlisib, BGT226, GDC.0941, PF.04691502, AZD6482, SB.2343, LY3023414, NVP.BEZ235, PKI.179, ZSTK.474, GSK2126458, PI3K.IN.2",0.742321425130815,0.370590400897281,FALSE +"H2126","Pearson.est","PLK inhibitor",0.72529,1.77,0.0123,296,0.136,"volasertib, rigosertib, GSK461364, BI.2536, HMN.214, NMS.1286937",1.9100948885606,0.866461091629782,TRUE +"H2126","Pearson.est","potassium channel blocker",0.46312,1.11,0.336,687,0.589,"ibutilide, dofetilide, mepivacaine, ML133",0.473660722610156,0.229884705212898,FALSE +"H2126","Pearson.est","PPAR receptor agonist",-0.71731,-1.94,0.00877,1393,0.158,"S26948, fenofibrate, GW.501516",2.05700040663396,0.801342913045577,TRUE +"H2126","Pearson.est","progesterone receptor agonist",0.59145,1.42,0.0846,317,0.39,"nomegestrol.acetate, tanaproget, norethindrone, danazol",1.07262963696098,0.408935392973501,FALSE +"H2126","Pearson.est","proteasome inhibitor",0.31107,0.741,0.781,355,0.926,"MG.132, delanzomib",0.1073489661227,0.0333890133180656,FALSE +"H2126","Pearson.est","protein synthesis inhibitor",0.58536,1.39,0.114,391,0.377,"clofoctol, cycloheximide, thiostrepton, mercaptopurine, homoharringtonine, puromycin, emetine, harringtonine, tedizolid.phosphate, anguidine",0.943095148663527,0.423658649794207,FALSE +"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.36486,-1.01,0.414,1359,0.561,"CP.724714, BMS.599626",0.382999658879101,0.251037138743839,FALSE +"H2126","Pearson.est","RAF inhibitor",0.50868,1.23,0.224,585,0.449,"RAF265, regorafenib, sorafenib, LGX818, SB.590885, PLX.4720, CEP.32496",0.649751981665837,0.347753658996677,FALSE +"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.533,1.3,0.16,389,0.408,"regorafenib, sorafenib, cabozantinib",0.795880017344075,0.38933983691012,FALSE +"H2126","Pearson.est","retinoid receptor agonist",0.64758,1.58,0.0252,340,0.385,"adapalene, fenretinide, adarotene, LE.135",1.59859945921846,0.414539270491499,FALSE +"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.68695,1.69,0.0244,198,0.208,"fludarabine.phosphate, clofarabine, triapine, gemcitabine, cladribine",1.61261017366127,0.681936665037238,TRUE +"H2126","Pearson.est","serotonin receptor agonist",0.47908,1.15,0.289,1,0.563,"aripiprazole",0.539102157243452,0.249491605148654,FALSE +"H2126","Pearson.est","serotonin receptor antagonist",0.56619,1.36,0.129,490,0.391,"aripiprazole, pirenperone, SB.200646, sertindole, RS.16566, lerisetron",0.889410289700751,0.407823242604133,FALSE +"H2126","Pearson.est","sodium channel blocker",0.30856,0.738,0.815,341,0.896,"butamben, cibenzoline, quinidine, brivaracetam",0.0888423912600234,0.0476919903378748,FALSE +"H2126","Pearson.est","src inhibitor",0.35082,0.835,0.674,726,0.857,"PP.1, dasatinib, KX2.391, PP.2, masitinib, TG.100572, saracatinib",0.17134010346468,0.0670191780768018,FALSE +"H2126","Pearson.est","sterol demethylase inhibitor",0.45453,1.1,0.351,487,0.592,"chlormidazole, lanoconazole, posaconazole, ketoconazole",0.454692883534176,0.22767829327708,FALSE +"H2126","Pearson.est","TGF beta receptor inhibitor",-0.4681,-1.3,0.199,675,0.313,"adaprev, D.4476, SB.431542, LY2109761, SB.525334, repsox",0.701146923590293,0.504455662453552,FALSE +"H2126","Pearson.est","thymidylate synthase inhibitor",0.56721,1.39,0.104,476,0.377,"doxifluridine, raltitrexed, capecitabine, trifluridine",0.98296666070122,0.423658649794207,FALSE +"H2126","Pearson.est","topoisomerase inhibitor",0.73992,1.78,0.00543,256,0.166,"topotecan, doxorubicin, etoposide.phosphate, mitoxantrone, teniposide, TAS.103, nemorubicin, etoposide, voreloxin, daunorubicin, dexrazoxane, SN.38, valrubicin, idarubicin, amsacrine, rubitecan, irinotecan, exatecan.mesylate, camptothecin, genz.644282",2.26520017041115,0.779891911959945,TRUE +"H2126","Pearson.est","tubulin polymerization inhibitor",0.59468,1.46,0.0801,442,0.393,"BNC105, vinblastine, verubulin, taltobulin, fosbretabulin, paclitaxel, mebendazole, vindesine, ABT.751, parbendazole, vinorelbine, vincristine, KX2.391, podophyllotoxin, CYT.997, flubendazole, dolastatin.10, plinabulin, epothilone.b, docetaxel, epothilone.d",1.09636748391576,0.405607449624573,FALSE +"H2126","Pearson.est","tyrosine kinase inhibitor",0.28711,0.681,0.849,578,0.931,"tivantinib, regorafenib, NVP.TAE226, dasatinib, UNC2250, sorafenib, cabozantinib, PP.121, tyrphostin.AG.99, mubritinib, tyrphostin.A9, aminopurvalanol.a, bafetinib, AMG.208",0.0710923097560473,0.0310503190186574,FALSE +"H2126","Pearson.est","VEGFR inhibitor",0.40622,0.988,0.488,389,0.733,"RAF265, dovitinib, pazopanib, OSI.930, regorafenib, axitinib, foretinib, SAR131675, MK.2461, motesanib, tivozanib, lenvatinib, sorafenib, ENMD.2076, cabozantinib",0.311580177997289,0.134896025358872,FALSE +"H2126","Pearson.est","vitamin D receptor agonist",-0.91214,-2.58,0,1409,0,"ercalcitriol, maxacalcitol, alfacalcidol, doxercalciferol, paricalcitol, tacalcitol",Inf,Inf,TRUE +"H3255","Pearson.est","EGFR inhibitor",-0.86237,-2.2,0,1354,0.00812,"icotinib, AST.1306, AEE788, BIBX.1382, WZ8040, TAK.285, BIBU.1361, rociletinib, CUDC.101, vandetanib, WZ.4002, gefitinib, PD.168393, BMS.599626, XL.647, lapatinib, ARRY.334543, neratinib, CP.724714, dacomitinib, tucatinib, erlotinib, BMS.690514, pelitinib, AZD8931, canertinib, poziotinib, osimertinib, afatinib",Inf,2.09044397075882,TRUE +"H3255","Pearson.est","Abl kinase inhibitor",-0.34308,-0.849,0.623,1389,0.918,"bosutinib, ZM.306416",0.20551195334083,0.0371573187987575,FALSE +"H3255","Pearson.est","acetylcholine receptor agonist",0.29084,0.725,0.793,236,0.903,"tremorine, nicotine",0.100726812682396,0.0443122496864942,FALSE +"H3255","Pearson.est","acetylcholine receptor antagonist",0.68859,1.76,0.015,181,0.206,"dicycloverine, iododexetimide, methscopolamine",1.82390874094432,0.686132779630847,TRUE +"H3255","Pearson.est","adenosine receptor antagonist",-0.67191,-1.67,0.0501,1341,0.243,"SCH.58261, MRS.1220, CGS.15943",1.30016227413275,0.614393726401688,FALSE +"H3255","Pearson.est","adrenergic receptor agonist",0.18702,0.468,0.977,1180,0.988,"terbutaline, norepinephrine, xylazine, clenbuterol, A61603, isoetharine, ritodrine, lidamidine, midodrine, epinephrine, oxymetazoline, isoxsuprine, buphenine, methyldopa, metaraminol",0.0101054362812269,0.00524305541237188,FALSE +"H3255","Pearson.est","adrenergic receptor antagonist",0.24896,0.625,0.912,351,0.938,"atenolol......, levobunolol, metoprolol, idazoxan, atenolol...., carvedilol",0.0400051616715838,0.0277971616209356,FALSE +"H3255","Pearson.est","AKT inhibitor",-0.64833,-1.61,0.0426,1132,0.251,"palomid.529, AZD5363, triciribine, CCT128930, GSK2110183, A.674563, GDC.0068, uprosertib",1.37059040089728,0.600326278518962,FALSE +"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.24367,-0.603,0.919,1055,0.992,"NVP.TAE684, CEP.37440, AZD3463, brigatinib",0.0366844886138887,0.00348832784582135,FALSE +"H3255","Pearson.est","androgen receptor antagonist",0.59939,1.46,0.0933,307,0.571,"bicalutamide, nilutamide, cyproterone.acetate",1.0301183562535,0.243363891754152,FALSE +"H3255","Pearson.est","antioxidant",0.2778,0.692,0.835,487,0.905,"chlorogenic.acid, taurine, mesna, trolox",0.0783135245163979,0.0433514207947967,FALSE +"H3255","Pearson.est","AP inhibitor",0.38888,1,0.438,273,0.735,"LCL.161, idronoxil, GDC.0152",0.3585258894959,0.133712660915805,FALSE +"H3255","Pearson.est","ATPase inhibitor",0.49063,1.25,0.226,189,0.712,"ouabain, digitoxin, digitoxigenin, digoxin",0.645891560852599,0.147520006363144,FALSE +"H3255","Pearson.est","Aurora kinase inhibitor",-0.18526,-0.464,0.988,264,0.989,"tozasertib, barasertib.HQPA, MK.5108, hesperadin, AMG900, barasertib, SNS.314, KW.2449, AT.9283, PF.03814735, ENMD.2076, alisertib, MK.8745, CCT137690, CYC116, CCT129202, danusertib, GSK1070916, TAK.901, ZM.447439, aurora.a.inhibitor.i, MLN.8054, PHA.680632",0.00524305541237188,0.0048037084028206,FALSE +"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34296,-0.853,0.622,1153,0.949,"azalomycin.b, azithromycin, tedizolid",0.206209615309181,0.0227337875727074,FALSE +"H3255","Pearson.est","bacterial DNA gyrase inhibitor",0.3999,1.01,0.444,426,0.771,"sparfloxacin, novobiocin, norfloxacin",0.35261702988538,0.112945621949043,FALSE +"H3255","Pearson.est","BCL inhibitor",0.42699,1.08,0.351,241,0.787,"TW.37, ABT.737, obatoclax, gossypol",0.454692883534176,0.104025267640935,FALSE +"H3255","Pearson.est","Bcr.Abl kinase inhibitor",0.28738,0.726,0.793,417,0.925,"nilotinib, tozasertib, bafetinib, ponatinib, GZD824",0.100726812682396,0.0338582672609674,FALSE +"H3255","Pearson.est","benzodiazepine receptor agonist",-0.21394,-0.536,0.954,307,1,"indiplon, lorazepam, eprinomectin, CGS.20625, CL.218872, bentazepam, nefiracetam, zaleplon, temazepam, ZK.93423, gamma.aminobutyric.acid, ivermectin, piperazine",0.0204516252959049,0,FALSE +"H3255","Pearson.est","bromodomain inhibitor",-0.68296,-1.72,0.0418,1250,0.222,"JQ1...., OTX015, I.BET151",1.37882371822496,0.653647025549361,TRUE +"H3255","Pearson.est","calcium channel blocker",0.28955,0.728,0.788,274,0.947,"pranidipine, carboxyamidotriazole, mibefradil",0.103473782510445,0.0236500209967266,FALSE +"H3255","Pearson.est","CC chemokine receptor antagonist",-0.45357,-1.14,0.289,1380,0.656,"ZK811752",0.539102157243452,0.18309616062434,FALSE +"H3255","Pearson.est","CDK inhibitor",-0.21009,-0.532,0.969,1327,0.988,"aminopurvalanol.a, indisulam, arcyriaflavin.a",0.0136762229492347,0.00524305541237188,FALSE +"H3255","Pearson.est","CHK inhibitor",0.28871,0.73,0.786,464,0.97,"SCH.900776, LY2606368, SB.218078, AZD7762",0.104577453960592,0.0132282657337552,FALSE +"H3255","Pearson.est","cyclooxygenase inhibitor",-0.36669,-0.906,0.547,1113,0.886,"aspirin, FR.122047, tryptanthrin, pterostilbene, phenazone, ketoprofen, FK.3311, AM.404, ramifenazone",0.262012673666569,0.0525662781129492,FALSE +"H3255","Pearson.est","cytochrome P450 inhibitor",0.79098,2.01,0,272,0.0411,"itraconazole, eplerenone, metyrapone, clotrimazole, cobicistat, morin",Inf,1.38615817812393,TRUE +"H3255","Pearson.est","DNA alkylating agent",0.41804,1.05,0.375,277,0.818,"carboplatin, carmustine, temozolomide, cisplatin, TH.302, dianhydrogalactitol, streptozotocin",0.425968732272281,0.087246696328677,FALSE +"H3255","Pearson.est","DNA inhibitor",0.38807,0.996,0.45,203,0.716,"carboplatin, carmustine, pibenzimol, chlorambucil",0.346787486224656,0.145086977692144,FALSE +"H3255","Pearson.est","DNA methyltransferase inhibitor",-0.47916,-1.18,0.281,1405,0.666,"SGI.1027, fdcyd",0.55129368009492,0.176525770829699,FALSE +"H3255","Pearson.est","DNA polymerase inhibitor",-0.45588,-1.16,0.264,1135,0.659,"adefovir.dipivoxil, famciclovir, cephalomannine, cidofovir",0.578396073130169,0.18111458540599,FALSE +"H3255","Pearson.est","DNA synthesis inhibitor",0.47593,1.19,0.256,453,0.752,"cyclocytidine, altretamine, cisplatin, artesunate, estramustine.phosphate, nelarabine, CB.10.277, azodicarbonamide",0.59176003468815,0.123782159408358,FALSE +"H3255","Pearson.est","dopamine receptor antagonist",0.42752,1.08,0.348,226,0.787,"raclopride, isofloxythepin, amisulpride, paliperidone, domperidone",0.458420756053419,0.104025267640935,FALSE +"H3255","Pearson.est","estrogen receptor agonist",0.30939,0.794,0.708,643,0.917,"estradiol, PPT, estrone, estradiol.cypionate",0.149966742310231,0.0376306643299789,FALSE +"H3255","Pearson.est","estrogen receptor antagonist",-0.26584,-0.65,0.861,1288,0.971,"raloxifene",0.0649968485463452,0.0127807700919951,FALSE +"H3255","Pearson.est","FGFR inhibitor",0.29662,0.736,0.788,609,0.987,"erdafitinib, dovitinib, AZD4547, lenvatinib, nintedanib, MK.2461",0.103473782510445,0.00568284733036327,FALSE +"H3255","Pearson.est","FLT3 inhibitor",0.40101,1,0.441,347,0.735,"gilteritinib, sunitinib, dovitinib, tozasertib, tyrphostin.AG.1296, ponatinib, TG.101348",0.355561410532161,0.133712660915805,FALSE +"H3255","Pearson.est","glucocorticoid receptor agonist",0.55433,1.38,0.118,473,0.702,"fluticasone.propionate, dexamethasone.acetate, prednisolone.hemisuccinate, halcinonide, flumethasone.pivalate, hydrocortisone, piretanide, triamcinolone, desonide, flumethasone, fluocinolone.acetonide, halobetasol.propionate, clobetasol.propionate, difluprednate, prednisolone.acetate, prednisolone, deflazacort",0.928117992693875,0.153662887870195,FALSE +"H3255","Pearson.est","glutamate receptor antagonist",-0.26837,-0.674,0.837,1094,0.971,"ACDPP, diazooxonorleucine, IEM1754, LY456236, latrepirdine",0.07727454200674,0.0127807700919951,FALSE +"H3255","Pearson.est","glycogen synthase kinase inhibitor",0.38135,0.95,0.501,371,0.748,"CHIR.98014, CHIR.99021, tideglusib, TWS.119",0.300162274132754,0.126098402135539,FALSE +"H3255","Pearson.est","growth factor receptor inhibitor",-0.38118,-0.942,0.529,1221,0.852,"AZD3463, GW.441756",0.276544327964814,0.0695604052332999,FALSE +"H3255","Pearson.est","HCV inhibitor",0.45154,1.14,0.317,498,0.774,"Ro.9187, daclatasvir, mericitabine, embelin",0.498940737782249,0.111259039317107,FALSE +"H3255","Pearson.est","HDAC inhibitor",-0.64377,-1.61,0.0529,1202,0.251,"trichostatin.a, R306465, scriptaid, RG2833, belinostat, vorinostat, M.344, panobinostat, givinostat, PCI.24781, SB.939, JNJ.26481585",1.27654432796481,0.600326278518962,FALSE +"H3255","Pearson.est","histamine receptor antagonist",-0.29447,-0.719,0.773,1147,1,"cyproheptadine, terfenadine, ebastine, tecastemizole, zolantidine, levocetirizine, ranitidine",0.111820506081675,0,FALSE +"H3255","Pearson.est","HMGCR inhibitor",0.87185,2.18,0,56,0.00986,"mevastatin, atorvastatin, pitavastatin, fluvastatin",Inf,2.00612308505879,TRUE +"H3255","Pearson.est","HSP inhibitor",-0.43214,-1.07,0.354,1092,0.754,"VER.49009, BIIB021, XL888, guanidine, KW.2478, alvespimycin, tanespimycin",0.450996737974212,0.122628654130226,FALSE +"H3255","Pearson.est","JAK inhibitor",-0.32917,-0.816,0.675,941,0.943,"lestaurtinib, AZD1480, WHI.P154, pacritinib, atiprimod, ruxolitinib, TG.02, CEP.33779, LY2784544",0.170696227168975,0.0254883072626717,FALSE +"H3255","Pearson.est","KIT inhibitor",0.21685,0.546,0.945,233,0.979,"telatinib, cediranib, sunitinib",0.0245681914907371,0.00921730819686218,FALSE +"H3255","Pearson.est","MDM inhibitor",0.52168,1.3,0.176,118,0.651,"idasanutlin, AMG.232, nutlin.3",0.75448733218585,0.186419011431808,FALSE +"H3255","Pearson.est","MEK inhibitor",0.38106,0.957,0.48,480,0.76,"cobimetinib, PD.318088, MEK162, PD.0325901, refametinib, selumetinib, BIX.02188",0.318758762624413,0.119186407719209,FALSE +"H3255","Pearson.est","MET inhibitor",-0.30289,-0.753,0.746,1182,1,"NVP.BVU972, INC.280",0.127261172527331,0,FALSE +"H3255","Pearson.est","microtubule inhibitor",0.52519,1.33,0.176,311,0.694,"secnidazole, vinblastine, estramustine.phosphate, triclabendazole",0.75448733218585,0.158640529545145,FALSE +"H3255","Pearson.est","mTOR inhibitor",-0.54284,-1.33,0.16,1132,0.447,"palomid.529, PI.103, deforolimus, GDC.0980, PP242, WYE.125132, PKI.179, voxtalisib, GSK2126458, AZD8055, temsirolimus, torin.2, everolimus, PF.05212384, sirolimus",0.795880017344075,0.349692476868064,FALSE +"H3255","Pearson.est","NFkB pathway inhibitor",0.31596,0.804,0.671,184,0.928,"betulinic.acid, BAY.11.7082",0.173277479831008,0.0324520237811379,FALSE +"H3255","Pearson.est","opioid receptor agonist",0.47813,1.19,0.274,230,0.752,"cebranopadol, BW.180C, trimebutine",0.562249437179612,0.123782159408358,FALSE +"H3255","Pearson.est","p38 MAPK inhibitor",-0.81599,-2.03,0,1178,0.041,"CMPD.1, VX.702, talmapimod, SB.242235, TAK.715, SB.239063",Inf,1.38721614328026,TRUE +"H3255","Pearson.est","PARP inhibitor",0.28433,0.707,0.804,508,0.907,"AG.14361, olaparib, endo.IWR.1, AZD2461",0.0947439512515487,0.0423927129399047,FALSE +"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.41323,1.02,0.412,383,0.78,"CP.673451, SU014813, telatinib, sunitinib, dovitinib, linifanib, ponatinib, pazopanib, axitinib",0.385102783966865,0.10790539730952,FALSE +"H3255","Pearson.est","phosphatase inhibitor",0.44294,1.11,0.32,42,0.802,"GSK2830371, bis.maltolato.oxovanadium.IV.",0.494850021680094,0.0958256317158365,FALSE +"H3255","Pearson.est","phosphodiesterase inhibitor",-0.29334,-0.723,0.767,1091,1,"cilostamide, EMD.53998, avanafil, papaverine",0.115204636051019,0,FALSE +"H3255","Pearson.est","PI3K inhibitor",-0.37309,-0.95,0.482,1136,0.921,"PI.103, PI.828, GDC.0980, TG.100713, PKI.179, voxtalisib, GSK2126458, CUDC.907, PF.05212384, taselisib, CH5132799, alpelisib",0.31695296176115,0.0357403698031511,FALSE +"H3255","Pearson.est","PLK inhibitor",-0.61349,-1.56,0.074,1284,0.233,"BI.2536, HMN.214, NMS.1286937",1.13076828026902,0.632644078973981,FALSE +"H3255","Pearson.est","potassium channel blocker",0.65813,1.67,0.0323,285,0.252,"mepivacaine, dofetilide, ibutilide, ML133",1.4907974776689,0.598599459218456,FALSE +"H3255","Pearson.est","PPAR receptor agonist",0.55181,1.37,0.129,29,0.656,"clofibrate, fenofibrate",0.889410289700751,0.18309616062434,FALSE +"H3255","Pearson.est","progesterone receptor agonist",0.51023,1.31,0.181,520,0.682,"norethindrone, norethindrone.acetate, nomegestrol.acetate, norgestrel, danazol",0.742321425130815,0.166215625343521,FALSE +"H3255","Pearson.est","proteasome inhibitor",0.42006,1.02,0.443,544,0.78,"MG.132, oprozomib, ixazomib, ixazomib.citrate, bortezomib",0.35359627377693,0.10790539730952,FALSE +"H3255","Pearson.est","protein synthesis inhibitor",-0.38205,-0.95,0.492,1166,0.921,"azomycin..2.nitroimidazole., homoharringtonine, cycloheximide, puromycin, bruceantin, tedizolid.phosphate, anguidine, chloramphenicol.palmitate",0.30803489723264,0.0357403698031511,FALSE +"H3255","Pearson.est","protein tyrosine kinase inhibitor",-0.76721,-1.9,0.00191,1391,0.0816,"tyrphostin.A9, AV.412, BMS.599626, CP.724714",2.71896663275227,1.08830984124614,TRUE +"H3255","Pearson.est","RAF inhibitor",0.75916,1.92,0.0124,137,0.0749,"vemurafenib, dabrafenib, AZ.628, SB.590885, TAK.632, LGX818",1.90657831483776,1.12551818230053,TRUE +"H3255","Pearson.est","RET tyrosine kinase inhibitor",-0.58773,-1.47,0.0895,1422,0.286,"vandetanib",1.04817696468409,0.543633966870957,FALSE +"H3255","Pearson.est","retinoid receptor agonist",-0.64321,-1.6,0.0581,1258,0.212,"bexarotene, CD.437, tamibarotene, adarotene",1.23582386760967,0.673664139071249,FALSE +"H3255","Pearson.est","ribonucleotide reductase inhibitor",0.60642,1.5,0.0813,268,0.546,"cladribine, clofarabine, hydroxyurea, gemcitabine, fludarabine.phosphate",1.08990945440593,0.262807357295263,FALSE +"H3255","Pearson.est","serotonin receptor agonist",0.66765,1.68,0.0338,231,0.285,"aripiprazole, SR.57227A",1.47108329972235,0.54515513999149,FALSE +"H3255","Pearson.est","serotonin receptor antagonist",0.4461,1.14,0.303,207,0.774,"aripiprazole, lerisetron, pirenperone, paliperidone, RS.16566",0.518557371497695,0.111259039317107,FALSE +"H3255","Pearson.est","sodium channel blocker",0.41024,1.03,0.411,106,0.826,"cibenzoline, mepivacaine, butamben, oxcarbazepine",0.386158178123931,0.0830199526796178,FALSE +"H3255","Pearson.est","src inhibitor",-0.6385,-1.6,0.0573,1261,0.212,"TG.100572, bosutinib, ZM.306416, saracatinib",1.24184537803261,0.673664139071249,FALSE +"H3255","Pearson.est","sterol demethylase inhibitor",0.34476,0.872,0.606,228,0.862,"posaconazole, sulconazole",0.217527375833714,0.0644927341752872,FALSE +"H3255","Pearson.est","TGF beta receptor inhibitor",-0.27847,-0.699,0.803,1016,0.967,"repsox, SB.431542, D.4476",0.095284454721319,0.0145735259169983,FALSE +"H3255","Pearson.est","thymidylate synthase inhibitor",0.32995,0.84,0.654,370,0.892,"doxifluridine, ftorafur",0.184422251675733,0.0496351456238769,FALSE +"H3255","Pearson.est","topoisomerase inhibitor",0.2633,0.659,0.865,414,0.924,"etoposide.phosphate, doxorubicin, nemorubicin, topotecan, teniposide, TAS.103, valrubicin, voreloxin, beta.lapachone",0.0629838925351858,0.0343280287798933,FALSE +"H3255","Pearson.est","tubulin polymerization inhibitor",-0.28647,-0.715,0.797,1199,0.976,"nocodazole, parbendazole, fenbendazole, plinabulin, indibulin, mebendazole",0.0985416786038876,0.0105501823333082,FALSE +"H3255","Pearson.est","tyrosine kinase inhibitor",-0.60066,-1.54,0.0727,1327,0.232,"aminopurvalanol.a, tivantinib, tyrphostin.A9, vandetanib, AV.412, BMS.599626, CP.724714",1.13846558914096,0.6345120151091,FALSE +"H3255","Pearson.est","VEGFR inhibitor",-0.38772,-0.942,0.538,1386,0.852,"AEE788, ZM.306416, vandetanib, XL.647, BMS.690514",0.269217724333611,0.0695604052332999,FALSE +"H3255","Pearson.est","vitamin D receptor agonist",-0.77633,-1.96,0.00204,1143,0.0574,"paricalcitol, tacalcitol, calcitriol, ercalcitriol, maxacalcitol",2.6903698325741,1.24108810760203,TRUE +"H358","Pearson.est","EGFR inhibitor",-0.86277,-2.13,0,1343,0.014,"CUDC.101, PD.153035, BIBX.1382, WZ.4002, rociletinib, brigatinib, CP.724714, BMS.599626, AEE788, icotinib, WZ8040, GW.583340, TAK.285, ARRY.334543, vandetanib, gefitinib, AST.1306, PD.168393, erlotinib, tucatinib, XL.647, neratinib, BMS.690514, lapatinib, AZD8931, dacomitinib, canertinib, pelitinib, osimertinib, poziotinib, afatinib",Inf,1.85387196432176,TRUE +"H358","Pearson.est","Abl kinase inhibitor",-0.44464,-1.1,0.352,1416,0.647,"dasatinib, bosutinib, ZM.306416",0.453457336521869,0.1890957193313,FALSE +"H358","Pearson.est","acetylcholine receptor agonist",0.59246,1.52,0.0747,240,0.479,"nefiracetam, nicotine, tremorine",1.1266793981846,0.319664486585437,FALSE +"H358","Pearson.est","acetylcholine receptor antagonist",0.46153,1.17,0.275,399,0.709,"iododexetimide, diphemanil, methscopolamine, dicycloverine",0.560667306169737,0.149353764816933,FALSE +"H358","Pearson.est","adenosine receptor antagonist",-0.47403,-1.15,0.31,1434,0.627,"CGS.15943",0.508638306165727,0.202732459169284,FALSE +"H358","Pearson.est","adrenergic receptor agonist",-0.53014,-1.31,0.181,836,0.523,"norepinephrine, terbutaline, epinephrine, A61603, metaraminol, oxymetazoline, isoetharine, methyldopa, midodrine, lidamidine, isoxsuprine",0.742321425130815,0.281498311132726,FALSE +"H358","Pearson.est","adrenergic receptor antagonist",-0.1899,-0.472,0.975,1044,1,"practolol, dihydroergocristine, vincamine, dronedarone, prazosin, RS.17053",0.0109953843014632,0,FALSE +"H358","Pearson.est","AKT inhibitor",-0.50123,-1.23,0.249,1326,0.589,"uprosertib, CCT128930, triciribine",0.603800652904264,0.229884705212898,FALSE +"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.56418,-1.37,0.174,1160,0.495,"CEP.37440, SB.505124, NVP.TAE684, crizotinib, AZD3463, brigatinib, AP26113",0.7594507517174,0.305394801066431,FALSE +"H358","Pearson.est","androgen receptor antagonist",0.37786,0.931,0.529,371,0.865,"nilutamide, bicalutamide",0.276544327964814,0.0629838925351858,FALSE +"H358","Pearson.est","antioxidant",0.65133,1.63,0.0349,353,0.476,"trolox, mesna, taurine, benfotiamine",1.45717457304082,0.322393047279507,FALSE +"H358","Pearson.est","AP inhibitor",0.39994,0.983,0.461,78,0.792,"idronoxil",0.336299074610352,0.101274818410506,FALSE +"H358","Pearson.est","ATPase inhibitor",0.42489,1.06,0.385,280,0.774,"oligomycin.a, digoxin, blebbistatin...., NMS.873",0.414539270491499,0.111259039317107,FALSE +"H358","Pearson.est","Aurora kinase inhibitor",-0.1713,-0.423,0.993,1027,0.995,"tozasertib, PHA.680632, danusertib, ZM.447439, TAK.901, GSK1070916, aurora.a.inhibitor.i, MLN.8054",0.00305075150461883,0.00217691925427455,FALSE +"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.2541,-0.622,0.895,1360,0.967,"azithromycin",0.048176964684088,0.0145735259169983,FALSE +"H358","Pearson.est","bacterial DNA gyrase inhibitor",0.23109,0.574,0.926,151,1,"nadifloxacin",0.0333890133180656,0,FALSE +"H358","Pearson.est","BCL inhibitor",0.47855,1.21,0.26,283,0.664,"gossypol, ABT.737, TW.37, venetoclax",0.585026652029182,0.177831920631982,FALSE +"H358","Pearson.est","Bcr.Abl kinase inhibitor",-0.35469,-0.861,0.612,1416,0.838,"dasatinib, bosutinib",0.213248577854439,0.0767559813697235,FALSE +"H358","Pearson.est","benzodiazepine receptor agonist",0.35095,0.866,0.611,470,0.835,"nefiracetam, lorazepam, bentazepam, indiplon, temazepam, zaleplon",0.213958789757446,0.0783135245163979,FALSE +"H358","Pearson.est","bromodomain inhibitor",0.26962,0.675,0.85,193,0.98,"bromosporine",0.0705810742857073,0.00877392430750515,FALSE +"H358","Pearson.est","calcium channel blocker",0.32481,0.821,0.646,197,0.86,"carboxyamidotriazole, pranidipine, mibefradil",0.189767482004916,0.0655015487564323,FALSE +"H358","Pearson.est","CC chemokine receptor antagonist",0.35561,0.901,0.552,105,0.8,"SB.225002",0.258060922270801,0.0969100130080564,FALSE +"H358","Pearson.est","CDK inhibitor",-0.26815,-0.659,0.854,1108,1,"alvocidib, BMS.265246, kenpaullone, BMS.387032, aminopurvalanol.a, PHA.793887, CR8..R., AT.7519",0.068542129310995,0,FALSE +"H358","Pearson.est","CHK inhibitor",-0.58873,-1.44,0.126,1000,0.455,"AZD7762, PF.477736, CHIR.124, SCH.900776, LY2606368, LY2603618",0.899629454882437,0.341988603342888,FALSE +"H358","Pearson.est","cyclooxygenase inhibitor",-0.41056,-1,0.429,1245,0.768,"FK.3311, AM.404, aspirin, ramifenazone, amfenac, tryptanthrin, phenazone",0.367542707815276,0.114638779968488,FALSE +"H358","Pearson.est","cytochrome P450 inhibitor",0.49933,1.28,0.215,463,0.774,"morin, PF.4981517, metyrapone, cobicistat, clotrimazole",0.667561540084395,0.111259039317107,FALSE +"H358","Pearson.est","DNA alkylating agent",0.27336,0.676,0.838,402,1,"carboplatin, streptozotocin, carmustine, melphalan, TH.302, temozolomide, dianhydrogalactitol",0.0767559813697235,0,FALSE +"H358","Pearson.est","DNA inhibitor",0.4898,1.24,0.238,438,0.642,"carboplatin, pibenzimol, oxaliplatin, chlorambucil, carmustine, melphalan, teroxirone, bendamustine, mechlorethamine, metronidazole",0.623423042943488,0.192464971931147,FALSE +"H358","Pearson.est","DNA methyltransferase inhibitor",-0.53313,-1.32,0.156,1255,0.544,"fdcyd, SGI.1027, azacitidine, decitabine",0.806875401645538,0.26440110030182,FALSE +"H358","Pearson.est","DNA polymerase inhibitor",-0.38778,-0.952,0.5,1261,0.764,"cidofovir, cephalomannine",0.301029995663981,0.11690664142431,FALSE +"H358","Pearson.est","DNA synthesis inhibitor",0.23119,0.578,0.936,573,1,"altretamine, artesunate, nelarabine, cyclocytidine, artemisinin, estramustine.phosphate, azodicarbonamide",0.0287241512618947,0,FALSE +"H358","Pearson.est","dopamine receptor antagonist",0.36593,0.909,0.566,437,0.842,"raclopride, thioproperazine, amisulpride, sertindole, domperidone, paliperidone, isofloxythepin, nemonapride, UH.232....",0.247183568811729,0.0746879085003505,FALSE +"H358","Pearson.est","estrogen receptor agonist",-0.2643,-0.655,0.872,1223,0.985,"equol, levonorgestrel",0.0594835150674328,0.00656376950238827,FALSE +"H358","Pearson.est","estrogen receptor antagonist",0.50946,1.27,0.204,238,0.731,"danazol, fulvestrant, toremifene",0.690369832574101,0.13608262304214,FALSE +"H358","Pearson.est","FGFR inhibitor",0.49484,1.25,0.229,190,0.667,"erdafitinib, regorafenib, orantinib",0.640164517660112,0.175874166083451,FALSE +"H358","Pearson.est","FLT3 inhibitor",0.19092,0.477,0.984,122,0.985,"TG.101348, GTP.14564",0.00700490156865849,0.00656376950238827,FALSE +"H358","Pearson.est","glucocorticoid receptor agonist",0.39694,0.991,0.458,361,0.809,"dexamethasone.acetate, piretanide, triamcinolone, halcinonide, prednisolone.hemisuccinate, flumethasone.pivalate, deflazacort, fluticasone.propionate, rimexolone, desonide",0.339134521996131,0.0920514783877277,FALSE +"H358","Pearson.est","glutamate receptor antagonist",0.30937,0.757,0.73,372,0.916,"MTPG, ACDPP, IEM1754, felbamate, JNJ.16259685",0.136677139879544,0.0381045263321496,FALSE +"H358","Pearson.est","glycogen synthase kinase inhibitor",-0.32297,-0.808,0.678,1180,0.844,"kenpaullone, AZD2858, LY2090314",0.168770306132937,0.073657553374345,FALSE +"H358","Pearson.est","growth factor receptor inhibitor",-0.34075,-0.839,0.625,937,0.849,"GW.441756, danusertib, AZD3463",0.204119982655925,0.0710923097560473,FALSE +"H358","Pearson.est","HCV inhibitor",0.51406,1.26,0.21,157,0.697,"mericitabine, narlaprevir",0.677780705266081,0.156767221901991,FALSE +"H358","Pearson.est","HDAC inhibitor",0.20852,0.522,0.978,416,1,"NSC.3852, nexturastat.a, M.344, entinostat, scriptaid, R306465, RGFP966, ACY.1215",0.00966114521239857,0,FALSE +"H358","Pearson.est","histamine receptor antagonist",-0.44366,-1.1,0.333,1189,0.647,"cimetidine, terfenadine, ranitidine, ebastine, levocetirizine, zolantidine",0.47755576649368,0.1890957193313,FALSE +"H358","Pearson.est","HMGCR inhibitor",0.80884,2.03,0,68,0.0305,"atorvastatin, mevastatin, fluvastatin, pitavastatin",Inf,1.51570016065321,TRUE +"H358","Pearson.est","HSP inhibitor",-0.79524,-1.99,0.00377,1299,0.0348,"guanidine, XL888, ganetespib, NVP.AUY922, tanespimycin, alvespimycin, PU.H71, KW.2478, VER.49009, BIIB021",2.42365864979421,1.45842075605342,TRUE +"H358","Pearson.est","JAK inhibitor",-0.23519,-0.574,0.935,1143,0.985,"LY2784544, pacritinib, CEP.33779, AZD1480, ruxolitinib",0.0291883891274822,0.00656376950238827,FALSE +"H358","Pearson.est","KIT inhibitor",-0.31418,-0.762,0.73,1165,0.891,"OSI.930, imatinib, midostaurin, tandutinib, dasatinib",0.136677139879544,0.0501222959631252,FALSE +"H358","Pearson.est","MDM inhibitor",0.83963,2.14,0,63,0.0161,"idasanutlin, AMG.232, nutlin.3, CGM097",Inf,1.79317412396815,TRUE +"H358","Pearson.est","MEK inhibitor",0.35837,0.906,0.546,502,0.819,"cobimetinib, U.0126, PD.318088, selumetinib, MEK162, arctigenin, MEK1.2.inhibitor, BIX.02188, refametinib, PD.0325901",0.262807357295263,0.0867160982395816,FALSE +"H358","Pearson.est","MET inhibitor",-0.63762,-1.56,0.06,1377,0.331,"LY2801653, INC.280",1.22184874961636,0.480172006224281,FALSE +"H358","Pearson.est","microtubule inhibitor",-0.49197,-1.2,0.268,1148,0.573,"colchicine, cytochalasin.b, podophyllotoxin, cabazitaxel",0.571865205971211,0.24184537803261,FALSE +"H358","Pearson.est","mTOR inhibitor",0.31414,0.795,0.71,427,0.879,"ku.0063794, XL388, LY303511, SB.2343, AZD2014, PF.04691502, WAY.600, WYE.125132, PP242, OSI.027, PI.103, torin.1, MLN0128",0.148741651280925,0.0560111249262281,FALSE +"H358","Pearson.est","NFkB pathway inhibitor",0.43885,1.1,0.341,275,0.732,"parthenolide...., tyloxapol, BAY.11.7082, betulinic.acid",0.467245621007502,0.135488918941608,FALSE +"H358","Pearson.est","opioid receptor agonist",0.4146,1.05,0.387,230,0.759,"BW.180C, trimebutine",0.412289034981089,0.11975822410452,FALSE +"H358","Pearson.est","p38 MAPK inhibitor",-0.60835,-1.53,0.0846,1002,0.341,"TAK.715, CMPD.1, talmapimod, SB.239063, SB.242235",1.07262963696098,0.467245621007502,FALSE +"H358","Pearson.est","PARP inhibitor",0.33832,0.859,0.64,285,0.821,"AG.14361, endo.IWR.1",0.193820026016113,0.0856568428805592,FALSE +"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.20056,0.511,0.971,190,0.996,"KI.8751, pazopanib, regorafenib, orantinib",0.0127807700919951,0.00174066157630127,FALSE +"H358","Pearson.est","phosphatase inhibitor",0.54531,1.37,0.137,159,0.696,"bis.maltolato.oxovanadium.IV., GSK2830371, BVT.948",0.863279432843593,0.157390760389438,FALSE +"H358","Pearson.est","phosphodiesterase inhibitor",0.43093,1.1,0.329,31,0.732,"anagrelide, GSK256066",0.482804102050026,0.135488918941608,FALSE +"H358","Pearson.est","PI3K inhibitor",-0.31741,-0.809,0.674,1308,0.87,"TG.100713, PIK.75, CH5132799, PF.05212384, alpelisib, taselisib",0.17134010346468,0.0604807473813815,FALSE +"H358","Pearson.est","PLK inhibitor",-0.67078,-1.65,0.0517,1091,0.274,"rigosertib, HMN.214, BI.2536, NMS.1286937",1.28650945690606,0.562249437179612,FALSE +"H358","Pearson.est","potassium channel blocker",0.36712,0.927,0.538,608,0.84,"mepivacaine, meglitinide, ML133, ibutilide",0.269217724333611,0.0757207139381184,FALSE +"H358","Pearson.est","PPAR receptor agonist",0.63054,1.62,0.0404,440,0.404,"clofibrate, fenofibrate, GW.501516, pterostilbene, S26948",1.3936186348894,0.393618634889395,FALSE +"H358","Pearson.est","progesterone receptor agonist",0.63394,1.61,0.0261,164,0.357,"norethindrone, norethindrone.acetate, tanaproget, danazol, norgestrel",1.58335949266172,0.447331783887807,FALSE +"H358","Pearson.est","proteasome inhibitor",-0.39174,-0.931,0.516,1025,0.772,"ixazomib.citrate, ixazomib, bortezomib, ONX.0914, carfilzomib",0.287350298372789,0.112382699664264,FALSE +"H358","Pearson.est","protein synthesis inhibitor",0.25116,0.627,0.909,268,1,"mercaptopurine, clofoctol, brefeldin.a, clindamycin.phosphate",0.0414361167780325,0,FALSE +"H358","Pearson.est","protein tyrosine kinase inhibitor",-0.7263,-1.76,0.0174,1399,0.161,"CP.724714, BMS.599626, AV.412",1.7594507517174,0.79317412396815,TRUE +"H358","Pearson.est","RAF inhibitor",0.79479,1.99,0.00789,179,0.0354,"dabrafenib, SB.590885, AZ.628, vemurafenib, LGX818, TAK.632, RAF265, regorafenib, GDC.0879",2.10292299679058,1.45099673797421,TRUE +"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.49567,-1.21,0.241,1426,0.589,"vandetanib",0.617982957425132,0.229884705212898,FALSE +"H358","Pearson.est","retinoid receptor agonist",-0.37036,-0.92,0.521,1290,0.763,"adarotene, CD.437, tamibarotene",0.283162276700476,0.11747546204512,FALSE +"H358","Pearson.est","ribonucleotide reductase inhibitor",0.50951,1.28,0.207,451,0.774,"triapine, cladribine, pentostatin, clofarabine, fludarabine, hydroxyurea, fludarabine.phosphate",0.684029654543082,0.111259039317107,FALSE +"H358","Pearson.est","serotonin receptor agonist",0.55504,1.4,0.146,175,0.694,"aripiprazole, NAN.190",0.835647144215563,0.158640529545145,FALSE +"H358","Pearson.est","serotonin receptor antagonist",0.41361,1.01,0.426,83,0.804,"aripiprazole, lerisetron",0.370590400897281,0.0947439512515487,FALSE +"H358","Pearson.est","sodium channel blocker",0.44857,1.14,0.318,119,0.731,"cibenzoline, benzethonium, butamben, quinidine",0.497572880015567,0.13608262304214,FALSE +"H358","Pearson.est","src inhibitor",-0.79685,-1.94,0.00398,1416,0.0434,"dasatinib, bosutinib, ZM.306416, saracatinib",2.40011692792631,1.36251027048749,TRUE +"H358","Pearson.est","sterol demethylase inhibitor",-0.39822,-0.961,0.491,1293,0.809,"lanoconazole",0.308918507877032,0.0920514783877277,FALSE +"H358","Pearson.est","TGF beta receptor inhibitor",-0.67317,-1.63,0.0435,1133,0.261,"SB.431542, D.4476, repsox",1.36151074304536,0.583359492661719,FALSE +"H358","Pearson.est","thymidylate synthase inhibitor",-0.26428,-0.654,0.862,1195,0.959,"capecitabine, carmofur",0.0644927341752872,0.0181813928293364,FALSE +"H358","Pearson.est","topoisomerase inhibitor",-0.38764,-0.956,0.496,1198,0.786,"etoposide, rubitecan, fleroxacin, licochalcone.a, SN.38, genz.644282, irinotecan, exatecan.mesylate, camptothecin",0.304518323509803,0.104577453960592,FALSE +"H358","Pearson.est","tubulin polymerization inhibitor",-0.56515,-1.4,0.145,1168,0.482,"fosbretabulin, mebendazole, vincristine, oxibendazole, indibulin, dolastatin.10, podophyllotoxin, nocodazole, parbendazole, epothilone.b, plinabulin, paclitaxel, docetaxel",0.838631997765025,0.31695296176115,FALSE +"H358","Pearson.est","tyrosine kinase inhibitor",-0.52248,-1.29,0.204,1399,0.522,"CP.724714, BMS.599626, dasatinib, tivantinib, vandetanib, AV.412",0.690369832574101,0.282329496997738,FALSE +"H358","Pearson.est","VEGFR inhibitor",-0.43401,-1.07,0.368,1341,0.67,"foretinib, AEE788, ZM.306416, vandetanib, XL.647, BMS.690514",0.434152181326482,0.173925197299174,FALSE +"H358","Pearson.est","vitamin D receptor agonist",-0.84099,-2.08,0,1302,0.0154,"tacalcitol, ercalcitriol, calcitriol, paricalcitol, maxacalcitol",Inf,1.81247927916354,TRUE +"A549","Pearson.est","EGFR inhibitor",0.8388,2.26,0,100,0.0178,"tucatinib, BMS.599626, osimertinib, poziotinib, AZD8931, CUDC.101, dacomitinib, AST.1306, afatinib, canertinib, WZ8040, pelitinib, BMS.690514, CP.724714, neratinib, ARRY.334543, lapatinib, AEE788, gefitinib, BIBU.1361, PD.168393, PD.153035, rociletinib, erlotinib, BIBX.1382, XL.647, CNX.2006, GW.583340, WZ.4002",Inf,1.74957999769111,TRUE +"A549","Pearson.est","Abl kinase inhibitor",-0.58184,-1.43,0.0924,1290,0.466,"metatinib, flumatinib, dasatinib, ponatinib, GZD824, nilotinib",1.03432802877989,0.33161408331,FALSE +"A549","Pearson.est","acetylcholine receptor agonist",-0.38662,-0.952,0.526,871,0.787,"nefiracetam, xanomeline, pilocarpine, nicotine",0.279014255846261,0.104025267640935,FALSE +"A549","Pearson.est","acetylcholine receptor antagonist",-0.51821,-1.24,0.231,1192,0.509,"darifenacin, iododexetimide, methscopolamine",0.636388020107856,0.293282217663241,FALSE +"A549","Pearson.est","adenosine receptor antagonist",0.67812,1.76,0.0251,86,0.107,"CGS.15943, MRS.1220, SCH.58261",1.60032627851896,0.97061622231479,TRUE +"A549","Pearson.est","adrenergic receptor agonist",-0.16272,-0.396,0.998,1160,0.998,"buphenine, clenbuterol",0.000869458712628891,0.000869458712628891,FALSE +"A549","Pearson.est","adrenergic receptor antagonist",-0.29013,-0.716,0.826,1112,0.985,"imiloxan, naftidrofuryl, carvedilol, levobunolol, idazoxan",0.0830199526796178,0.00656376950238827,FALSE +"A549","Pearson.est","AKT inhibitor",0.73638,1.88,0.0138,111,0.0874,"uprosertib, GDC.0068, AZD5363, CCT128930, GSK2110183",1.86012091359876,1.0584885673656,TRUE +"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.29121,-0.7,0.804,1433,0.984,"lorlatinib",0.0947439512515487,0.00700490156865849,FALSE +"A549","Pearson.est","androgen receptor antagonist",-0.52332,-1.29,0.192,923,0.46,"bicalutamide, cyproterone.acetate, flutamide, nilutamide",0.71669877129645,0.337242168318426,FALSE +"A549","Pearson.est","antioxidant",-0.63843,-1.59,0.0386,1041,0.328,"taurine, chlorogenic.acid, trolox, rutin, benfotiamine",1.41341269532825,0.484126156288321,FALSE +"A549","Pearson.est","AP inhibitor",-0.37272,-0.91,0.572,1415,0.779,"idronoxil",0.242603971206976,0.108462542327436,FALSE +"A549","Pearson.est","ATPase inhibitor",-0.73068,-1.77,0.0129,1321,0.205,"ouabain, digitoxin, k.strophanthidin, digoxin, digitoxigenin",1.88941028970075,0.688246138944246,TRUE +"A549","Pearson.est","Aurora kinase inhibitor",-0.27432,-0.663,0.851,847,0.987,"barasertib, CYC116, danusertib, PF.03814735, AT.9283, alisertib, KW.2449, AMG900, tozasertib, hesperadin, MK.8745, MK.5108",0.0700704399154121,0.00568284733036327,FALSE +"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.39151,-0.971,0.492,921,0.799,"dirithromycin, radezolid, tedizolid, valnemulin",0.30803489723264,0.0974532206860086,FALSE +"A549","Pearson.est","bacterial DNA gyrase inhibitor",-0.3102,-0.78,0.733,1254,0.912,"lomefloxacin, sparfloxacin",0.134896025358872,0.0400051616715838,FALSE +"A549","Pearson.est","BCL inhibitor",-0.33043,-0.799,0.707,1362,0.902,"gossypol",0.150580586203101,0.0447934624580583,FALSE +"A549","Pearson.est","Bcr.Abl kinase inhibitor",-0.74309,-1.81,0.00759,1290,0.221,"metatinib, flumatinib, dasatinib, ponatinib, GZD824, nilotinib",2.11975822410452,0.655607726314889,TRUE +"A549","Pearson.est","benzodiazepine receptor agonist",-0.22882,-0.556,0.957,871,1,"nefiracetam, CGS.20625, indiplon, lorazepam, bentazepam",0.0190880622231565,0,FALSE +"A549","Pearson.est","bromodomain inhibitor",0.78246,2.05,0.00277,186,0.0307,"I.BET151, PFI.1, JQ1...., OTX015",2.55752023093555,1.51286162452281,TRUE +"A549","Pearson.est","calcium channel blocker",0.21734,0.571,0.947,376,1,"fendiline, mibefradil, SR.33805, efonidipine.monoethanolate",0.0236500209967266,0,FALSE +"A549","Pearson.est","CC chemokine receptor antagonist",0.31668,0.83,0.62,373,0.9,"PF.04136309, ZK811752, RS.504393, SB.225002",0.207608310501746,0.0457574905606751,FALSE +"A549","Pearson.est","CDK inhibitor",-0.23091,-0.555,0.937,1359,1,"palbociclib, abemaciclib, PHA.848125",0.0282604091122217,0,FALSE +"A549","Pearson.est","CHK inhibitor",-0.23297,-0.567,0.947,1079,1,"LY2606368, SCH.900776",0.0236500209967266,0,FALSE +"A549","Pearson.est","cyclooxygenase inhibitor",-0.27802,-0.67,0.854,1193,0.999,"FK.3311, suxibuzone, acetylsalicylsalicylic.acid, AM.404, tepoxalin",0.068542129310995,0.000434511774017692,FALSE +"A549","Pearson.est","cytochrome P450 inhibitor",-0.58317,-1.41,0.113,925,0.44,"PF.4981517, clotrimazole, cobicistat, metyrapone",0.94692155651658,0.356547323513813,FALSE +"A549","Pearson.est","DNA alkylating agent",-0.52919,-1.31,0.154,1263,0.492,"temozolomide, carmustine, cisplatin, dianhydrogalactitol, carboplatin",0.812479279163537,0.30803489723264,FALSE +"A549","Pearson.est","DNA inhibitor",-0.46743,-1.15,0.293,1266,0.568,"carmustine, chlorambucil, teroxirone, carboplatin",0.533132379645891,0.245651664288981,FALSE +"A549","Pearson.est","DNA methyltransferase inhibitor",0.59335,1.56,0.0932,77,0.202,"SGI.1027, fdcyd, azacitidine",1.03058408764602,0.694648630553376,FALSE +"A549","Pearson.est","DNA polymerase inhibitor",0.35205,0.935,0.474,461,0.832,"cidofovir, cephalomannine, famciclovir, menadione, idoxuridine, adefovir.dipivoxil",0.324221658325915,0.0798766737092761,FALSE +"A549","Pearson.est","DNA synthesis inhibitor",-0.66192,-1.62,0.0351,1165,0.383,"altretamine, floxuridine, CB.10.277, cyclocytidine, azodicarbonamide, nelarabine, artemisinin, cisplatin",1.45469288353418,0.416801226031377,FALSE +"A549","Pearson.est","dopamine receptor antagonist",0.33839,0.864,0.586,148,0.88,"lurasidone, oxiperomide, domperidone, acetophenazine",0.232102383981909,0.0555173278498314,FALSE +"A549","Pearson.est","estrogen receptor agonist",0.23125,0.605,0.909,1115,1,"erteberel, equol, levonorgestrel, estrone, estradiol, ethinyl.estradiol, PPT, estradiol.cypionate",0.0414361167780325,0,FALSE +"A549","Pearson.est","estrogen receptor antagonist",0.52714,1.36,0.137,74,0.319,"tamoxifen, clomifene",0.863279432843593,0.496209316942819,FALSE +"A549","Pearson.est","FGFR inhibitor",-0.57331,-1.42,0.117,1046,0.452,"MK.2461, AZD4547, lenvatinib, nintedanib, regorafenib, erdafitinib",0.931814138253838,0.344861565188618,FALSE +"A549","Pearson.est","FLT3 inhibitor",-0.39978,-0.95,0.502,879,0.769,"lestaurtinib, dovitinib, tyrphostin.AG.1296, TG.101348, KW.2449, tozasertib, quizartinib, sorafenib, midostaurin, ponatinib, gilteritinib",0.299296282854981,0.114073660198569,FALSE +"A549","Pearson.est","glucocorticoid receptor agonist",-0.19133,-0.461,0.989,1002,1,"desonide, dexamethasone.acetate, flumethasone.pivalate, difluprednate, fluocinolone.acetonide, halobetasol.propionate, fluticasone.propionate",0.0048037084028206,0,FALSE +"A549","Pearson.est","glutamate receptor antagonist",0.46861,1.22,0.236,325,0.455,"latrepirdine, CGP.37849, CPP, IEM1754, LY456236, kynurenic.acid",0.627087997029893,0.341988603342888,FALSE +"A549","Pearson.est","glycogen synthase kinase inhibitor",0.18157,0.467,0.989,246,0.99,"indirubin, LY2090314",0.0048037084028206,0.00436480540245009,FALSE +"A549","Pearson.est","growth factor receptor inhibitor",0.37361,1.01,0.404,175,0.778,"GSK1904529A, GW.441756, AZD3463",0.393618634889395,0.109020403010311,FALSE +"A549","Pearson.est","HCV inhibitor",-0.36372,-0.895,0.586,1022,0.785,"embelin, Ro.9187, mericitabine",0.232102383981909,0.105130343254747,FALSE +"A549","Pearson.est","HDAC inhibitor",0.38293,1,0.411,275,0.749,"givinostat, R306465, PCI.24781, SB.939, pyroxamide, romidepsin, RG2833, JNJ.26481585",0.386158178123931,0.125518182300534,FALSE +"A549","Pearson.est","histamine receptor antagonist",0.22816,0.612,0.915,212,1,"chloropyramine, terfenadine, cyproheptadine, astemizole",0.0385789059335517,0,FALSE +"A549","Pearson.est","HMGCR inhibitor",-0.89094,-2.16,0,1437,0.00103,"atorvastatin, pitavastatin, mevastatin, fluvastatin",Inf,2.98716277529483,TRUE +"A549","Pearson.est","HSP inhibitor",-0.24376,-0.593,0.921,1043,1,"NVP.AUY922, PU.H71, ganetespib, SNX.2112, NMS.E973",0.0357403698031511,0,FALSE +"A549","Pearson.est","JAK inhibitor",-0.33766,-0.82,0.668,874,0.889,"PRT062070, lestaurtinib, AT.9283, baricitinib, TG.101348, WHI.P154, ruxolitinib, tozasertib, TG.101209, AZ960",0.175223537524454,0.0510982390297863,FALSE +"A549","Pearson.est","KIT inhibitor",-0.47634,-1.14,0.322,1155,0.567,"lenvatinib, sorafenib, midostaurin, regorafenib, dasatinib, pazopanib, KI.8751",0.492144128304169,0.246416941107093,FALSE +"A549","Pearson.est","MDM inhibitor",-0.57364,-1.36,0.151,1174,0.446,"CGM097, AMG.232, nutlin.3, idasanutlin",0.821023052706831,0.350665141287858,FALSE +"A549","Pearson.est","MEK inhibitor",0.80533,2.06,0.0138,142,0.0378,"trametinib, AS.703026, selumetinib, AZD8330, MEK162, PD.318088, TAK.733, PD.0325901, cobimetinib, PD.198306, Ro.4987655, PD.184352",1.86012091359876,1.42250820016277,TRUE +"A549","Pearson.est","MET inhibitor",-0.43916,-1.09,0.356,1418,0.638,"LY2801653",0.448550002027125,0.195179321278838,FALSE +"A549","Pearson.est","microtubule inhibitor",-0.52195,-1.26,0.216,1010,0.493,"cabazitaxel, D.64131, vinflunine, vinblastine, secnidazole",0.665546248849069,0.30715308072277,FALSE +"A549","Pearson.est","mTOR inhibitor",-0.54871,-1.32,0.159,1049,0.499,"everolimus, voxtalisib, torin.2, AZD8055, XL388, ku.0063794, SB.2343, AZD2014, PKI.179, temsirolimus, NVP.BEZ235, MLN0128, sirolimus, torin.1, WAY.600, LY3023414, deforolimus",0.798602875679548,0.30189945437661,FALSE +"A549","Pearson.est","NFkB pathway inhibitor",0.25653,0.68,0.846,283,1,"tyloxapol, Ro.106.9920, curcumin, parthenolide....",0.0726296369609765,0,FALSE +"A549","Pearson.est","opioid receptor agonist",-0.50313,-1.23,0.231,1168,0.505,"salvinorin.a, BW.180C, spiradoline",0.636388020107856,0.296708621881339,FALSE +"A549","Pearson.est","p38 MAPK inhibitor",0.51478,1.39,0.122,375,0.313,"skepinone.l, SB.239063, TAK.715, talmapimod",0.913640169325252,0.504455662453552,FALSE +"A549","Pearson.est","PARP inhibitor",-0.47245,-1.15,0.305,856,0.568,"niraparib, E7449, endo.IWR.1, AZD2461, olaparib, talazoparib, AG.14361",0.515700160653214,0.245651664288981,FALSE +"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.52221,-1.29,0.188,1155,0.46,"lenvatinib, nintedanib, sorafenib, crenolanib, regorafenib, dasatinib, ponatinib, pazopanib, KI.8751, CP.673451",0.72584215073632,0.337242168318426,FALSE +"A549","Pearson.est","phosphatase inhibitor",-0.47463,-1.18,0.286,1278,0.556,"BVT.948, GSK2830371, bis.maltolato.oxovanadium.IV.",0.543633966870957,0.254925208417942,FALSE +"A549","Pearson.est","phosphodiesterase inhibitor",-0.59434,-1.43,0.0951,1231,0.466,"YM.976, anagrelide, zardaverine, GSK256066",1.02181948306259,0.33161408331,FALSE +"A549","Pearson.est","PI3K inhibitor",-0.22358,-0.54,0.962,1042,0.996,"GDC.0941, voxtalisib, BGT226, AZD6482, SB.2343, idelalisib, ZSTK.474, PKI.179, NVP.BEZ235, LY3023414",0.0168249279621871,0.00174066157630127,FALSE +"A549","Pearson.est","PLK inhibitor",-0.61436,-1.52,0.0656,1304,0.434,"volasertib, rigosertib",1.18309616062434,0.362510270487489,FALSE +"A549","Pearson.est","potassium channel blocker",-0.59778,-1.45,0.0734,862,0.507,"ML133, mepivacaine, oleoylethanolamide, meglitinide, dofetilide, ibutilide",1.13430394008393,0.294992040666664,FALSE +"A549","Pearson.est","PPAR receptor agonist",0.6468,1.71,0.0373,157,0.121,"ciprofibrate, GW.501516, pterostilbene, S26948",1.42829116819131,0.91721462968355,TRUE +"A549","Pearson.est","progesterone receptor agonist",-0.53175,-1.29,0.19,1053,0.46,"norethindrone.acetate, norgestrel, tanaproget, nomegestrol.acetate, norethindrone",0.721246399047171,0.337242168318426,FALSE +"A549","Pearson.est","proteasome inhibitor",0.25378,0.657,0.857,241,1,"carfilzomib, ONX.0914",0.0670191780768018,0,FALSE +"A549","Pearson.est","protein synthesis inhibitor",-0.37338,-0.917,0.547,974,0.787,"methacycline, emetine, thiostrepton, florfenicol, harringtonine, cycloheximide, mercaptopurine",0.262012673666569,0.104025267640935,FALSE +"A549","Pearson.est","protein tyrosine kinase inhibitor",0.71444,1.86,0.016,46,0.0812,"BMS.599626, CP.724714, AV.412",1.79588001734408,1.09044397075882,TRUE +"A549","Pearson.est","RAF inhibitor",-0.39851,-0.991,0.464,1178,0.782,"LGX818, sorafenib, RAF265, regorafenib",0.333482019445119,0.106793246940152,FALSE +"A549","Pearson.est","RET tyrosine kinase inhibitor",-0.60093,-1.47,0.07,1200,0.505,"sorafenib, apatinib, regorafenib",1.15490195998574,0.296708621881339,FALSE +"A549","Pearson.est","retinoid receptor agonist",0.53837,1.43,0.127,170,0.297,"adarotene, tamibarotene, CD.437, AM.580",0.896196279044043,0.527243550682788,FALSE +"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.63612,-1.59,0.0574,1271,0.328,"gemcitabine, triapine, fludarabine.phosphate, cladribine, clofarabine",1.24108810760203,0.484126156288321,FALSE +"A549","Pearson.est","serotonin receptor agonist",-0.71849,-1.72,0.019,1315,0.226,"SR.57227A, aripiprazole",1.72124639904717,0.645891560852599,TRUE +"A549","Pearson.est","serotonin receptor antagonist",-0.4146,-1,0.44,1103,0.788,"RS.16566, pirenperone, lerisetron, SB.216641, aripiprazole",0.356547323513813,0.103473782510445,FALSE +"A549","Pearson.est","sodium channel blocker",-0.37723,-0.919,0.556,1255,0.805,"oxcarbazepine, quinidine, butamben, cibenzoline",0.254925208417942,0.0942041196321315,FALSE +"A549","Pearson.est","src inhibitor",0.22599,0.597,0.944,43,1,"ZM.306416",0.025028005701931,0,FALSE +"A549","Pearson.est","sterol demethylase inhibitor",-0.57159,-1.4,0.106,996,0.428,"posaconazole, chlormidazole, ketoconazole, lanoconazole",0.97469413473523,0.368556230986828,FALSE +"A549","Pearson.est","TGF beta receptor inhibitor",0.67721,1.83,0.0163,234,0.0828,"repsox, D.4476, SB.431542",1.78781239559604,1.08196966321512,TRUE +"A549","Pearson.est","thymidylate synthase inhibitor",-0.49813,-1.19,0.244,737,0.558,"capecitabine, trifluridine, doxifluridine, ftorafur",0.612610173661271,0.253365801062421,FALSE +"A549","Pearson.est","topoisomerase inhibitor",-0.56253,-1.36,0.117,1045,0.446,"amsacrine, SN.38, mitoxantrone, etoposide, idarubicin, nemorubicin, daunorubicin, dexrazoxane, voreloxin, rubitecan, doxorubicin, epirubicin, teniposide, TAS.103, topotecan, etoposide.phosphate",0.931814138253838,0.350665141287858,FALSE +"A549","Pearson.est","tubulin polymerization inhibitor",-0.38607,-0.954,0.529,1189,0.806,"vindesine, epothilone.d, mebendazole, vinblastine, verubulin, BNC105",0.276544327964814,0.0936649581949093,FALSE +"A549","Pearson.est","tyrosine kinase inhibitor",0.31846,0.865,0.613,122,0.927,"BMS.599626, CP.724714, AV.412, hypericin",0.212539525481585,0.0329202658555029,FALSE +"A549","Pearson.est","VEGFR inhibitor",0.19483,0.522,0.978,84,1,"BMS.690514, AEE788, ZM.306416, XL.647",0.00966114521239857,0,FALSE +"A549","Pearson.est","vitamin D receptor agonist",0.86079,2.25,0,145,0.00891,"maxacalcitol, tacalcitol, paricalcitol, alfacalcidol, calcitriol, ercalcitriol",Inf,2.05012229596313,TRUE +"HCC15","Pearson.est","EGFR inhibitor",-0.37293,-1.13,0.248,1256,0.693,"BMS.599626, PD.153035, brigatinib, FERb.033, erlotinib, dacomitinib, pelitinib, BIBU.1361, icotinib, canertinib, lapatinib, XL.647, BMS.690514, WZ.4002, PD.168393, vandetanib",0.605548319173784,0.159266765388193,FALSE +"HCC15","Pearson.est","Abl kinase inhibitor",-0.22761,-0.71,0.81,1446,0.899,"dasatinib",0.0915149811213502,0.0462403082667712,FALSE +"HCC15","Pearson.est","acetylcholine receptor agonist",0.51058,1.19,0.248,201,0.586,"xanomeline, oxiracetam, tremorine",0.605548319173784,0.232102383981909,FALSE +"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.33703,-0.993,0.4,486,0.862,"darifenacin, diphemanil, methscopolamine, hyoscyamine, iododexetimide, dicycloverine",0.397940008672038,0.0644927341752872,FALSE +"HCC15","Pearson.est","adenosine receptor antagonist",0.56939,1.33,0.125,250,0.557,"MRS.1220, SCH.58261, sulmazole",0.903089986991944,0.254144804826271,FALSE +"HCC15","Pearson.est","adrenergic receptor agonist",-0.23866,-0.734,0.834,342,0.908,"A61603, metaraminol, norepinephrine, buphenine, terbutaline, methyldopa, clenbuterol, epinephrine, oxymetazoline, xylazine, lidamidine, ritodrine, midodrine, isoxsuprine, isoetharine",0.0788339493622613,0.0419141514789149,FALSE +"HCC15","Pearson.est","adrenergic receptor antagonist",-0.23314,-0.668,0.809,1305,0.874,"metoprolol, naftidrofuryl, levobunolol, practolol",0.0920514783877277,0.058488567365597,FALSE +"HCC15","Pearson.est","AKT inhibitor",0.45118,1.07,0.405,557,0.711,"uprosertib, GDC.0068, MK.2206, AZD5363, ONC201, CCT128930, A.674563, GSK2110183",0.392544976785331,0.148130399270234,FALSE +"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.34379,-0.984,0.437,1257,0.815,"AP26113, brigatinib, GW.788388, lorlatinib",0.359518563029578,0.0888423912600234,FALSE +"HCC15","Pearson.est","androgen receptor antagonist",-0.64216,-1.95,0.00641,926,0.106,"flutamide, bicalutamide, enzalutamide, nilutamide, cyproterone.acetate, RU.58841",2.19314197048118,0.97469413473523,TRUE +"HCC15","Pearson.est","antioxidant",-0.70687,-2.04,0.0061,1340,0.202,"mesna, benfotiamine, trolox",2.21467016498923,0.694648630553376,TRUE +"HCC15","Pearson.est","AP inhibitor",0.38283,0.898,0.599,633,0.924,"idronoxil, birinapant, tanshinone.i",0.222573177610689,0.0343280287798933,FALSE +"HCC15","Pearson.est","ATPase inhibitor",0.63423,1.49,0.0581,242,0.456,"NMS.873, thonzonium, oligomycin.a, evodiamine, digoxin",1.23582386760967,0.341035157335565,FALSE +"HCC15","Pearson.est","Aurora kinase inhibitor",0.6275,1.44,0.0711,403,0.478,"TAK.901, barasertib, PHA.680632, danusertib, barasertib.HQPA, AMG900, SNS.314, GSK1070916, ZM.447439, CCT137690, aurora.a.inhibitor.i, MK.5108, alisertib, tozasertib, AT.9283, ENMD.2076, KW.2449",1.14813039927023,0.320572103387881,FALSE +"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.27431,-0.796,0.717,395,1,"azalomycin.b, valnemulin, azithromycin, radezolid, tedizolid, tilmicosin, josamycin, dirithromycin",0.1444808443322,0,FALSE +"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",-0.25972,-0.784,0.767,374,0.965,"trovafloxacin, novobiocin, sarafloxacin, sparfloxacin, nadifloxacin, lomefloxacin, norfloxacin, finafloxacin",0.115204636051019,0.0154726866562074,FALSE +"HCC15","Pearson.est","BCL inhibitor",0.4201,0.992,0.476,189,0.839,"TW.37, oridonin",0.322393047279507,0.0762380391712997,FALSE +"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",-0.26327,-0.76,0.783,1446,0.912,"dasatinib",0.106238237942057,0.0400051616715838,FALSE +"HCC15","Pearson.est","benzodiazepine receptor agonist",0.22155,0.524,0.972,220,0.986,"ZK.93423, bentazepam",0.0123337350737254,0.0061230850587888,FALSE +"HCC15","Pearson.est","bromodomain inhibitor",0.75211,1.81,0.00248,271,0.114,"PFI.1, I.BET151, OTX015, JQ1...., bromosporine",2.60554831917378,0.943095148663527,TRUE +"HCC15","Pearson.est","calcium channel blocker",0.51456,1.22,0.225,579,0.561,"mibefradil, penfluridol, carboxyamidotriazole, pranidipine, SR.33805, tetrandrine, efonidipine.monoethanolate",0.647817481888638,0.251037138743839,FALSE +"HCC15","Pearson.est","CC chemokine receptor antagonist",0.58015,1.36,0.11,450,0.614,"SB.225002, UNBS.5162, PF.04136309, MK.0812, RS.504393",0.958607314841775,0.211831628858832,FALSE +"HCC15","Pearson.est","CDK inhibitor",0.37946,0.892,0.621,578,0.913,"indisulam, arcyriaflavin.a, BMS.387032, PHA.793887, dinaciclib, AT.7519, TG.02, JNJ.7706621, indirubin, R547, P276.00",0.20690839982342,0.039529222465701,FALSE +"HCC15","Pearson.est","CHK inhibitor",0.47034,1.1,0.359,229,0.666,"PF.477736, SB.218078",0.444905551421681,0.176525770829699,FALSE +"HCC15","Pearson.est","cyclooxygenase inhibitor",0.15596,0.366,0.999,813,0.999,"curcumin, piroxicam, pterostilbene, sulfasalazine, FR.122047, suxibuzone, meloxicam, amfenac, tepoxalin, AM.404, metoxibutropate, ketoprofen",0.000434511774017692,0.000434511774017692,FALSE +"HCC15","Pearson.est","cytochrome P450 inhibitor",-0.56262,-1.65,0.0427,1248,0.263,"clotrimazole, itraconazole, metyrapone, eplerenone",1.36957212497498,0.580044251510242,FALSE +"HCC15","Pearson.est","DNA alkylating agent",0.31065,0.744,0.812,434,1,"estramustine, melphalan, satraplatin, cisplatin, mitomycin.c",0.0904439707588247,0,FALSE +"HCC15","Pearson.est","DNA inhibitor",0.33459,0.789,0.756,676,0.984,"valrubicin, chlorambucil, melphalan, pibenzimol, teroxirone, bendamustine, mechlorethamine, primaquine, tirapazamine, sangivamycin, oxaliplatin, busulfan",0.121478204498793,0.00700490156865849,FALSE +"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.61969,1.46,0.0687,414,0.478,"fdcyd, SGI.1027, disulfiram, azacitidine",1.16304326294045,0.320572103387881,FALSE +"HCC15","Pearson.est","DNA polymerase inhibitor",0.60732,1.43,0.0763,485,0.458,"cephalomannine, adefovir.dipivoxil, menadione, cidofovir, trifluridine, idoxuridine",1.11747546204512,0.339134521996131,FALSE +"HCC15","Pearson.est","DNA synthesis inhibitor",0.22956,0.539,0.967,664,1,"floxuridine, enocitabine, cisplatin, mitomycin.c, estramustine.phosphate, artemisinin, anisomycin, altretamine",0.0145735259169983,0,FALSE +"HCC15","Pearson.est","dopamine receptor antagonist",-0.27274,-0.788,0.681,1187,1,"remoxipride, piperacetazine, raclopride, ziprasidone, clebopride, acetophenazine, oxiperomide",0.166852888087215,0,FALSE +"HCC15","Pearson.est","estrogen receptor agonist",-0.35436,-0.972,0.456,1327,0.784,"ethinyl.estradiol, equol",0.341035157335565,0.105683937315562,FALSE +"HCC15","Pearson.est","estrogen receptor antagonist",0.24712,0.58,0.935,457,1,"danazol, fulvestrant",0.0291883891274822,0,FALSE +"HCC15","Pearson.est","FGFR inhibitor",0.48614,1.15,0.304,374,0.613,"dovitinib, erdafitinib, regorafenib, PD.173074, MK.2461",0.517126416391246,0.212539525481585,FALSE +"HCC15","Pearson.est","FLT3 inhibitor",0.54249,1.27,0.17,433,0.548,"dovitinib, GTP.14564, lestaurtinib, tyrphostin.AG.1296, tozasertib, ENMD.2076, pacritinib, quizartinib, KW.2449, TG.101348, TG.02, sunitinib",0.769551078621726,0.261219441515631,FALSE +"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.42288,-1.24,0.215,1303,0.601,"prednisolone.acetate, flumethasone, fluticasone.propionate, fluocinolone.acetonide, beclomethasone.dipropionate, hydrocortisone",0.667561540084395,0.22112552799726,FALSE +"HCC15","Pearson.est","glutamate receptor antagonist",0.29186,0.695,0.839,277,1,"ACDPP, felbamate, CGP.37849",0.0762380391712997,0,FALSE +"HCC15","Pearson.est","glycogen synthase kinase inhibitor",0.3692,0.869,0.651,22,0.934,"AZD2858",0.186419011431808,0.0296531237699066,FALSE +"HCC15","Pearson.est","growth factor receptor inhibitor",0.52399,1.23,0.211,142,0.563,"danusertib, lestaurtinib",0.675717544702307,0.249491605148654,FALSE +"HCC15","Pearson.est","HCV inhibitor",0.39243,0.914,0.586,443,0.915,"narlaprevir, mericitabine",0.232102383981909,0.0385789059335517,FALSE +"HCC15","Pearson.est","HDAC inhibitor",0.74271,1.74,0.00357,212,0.114,"R306465, PCI.24781, M.344, SB.939, givinostat, trichostatin.a, entinostat, ACY.1215, dacinostat, vorinostat, RGFP966, AR.42, belinostat, resminostat, nexturastat.a, scriptaid, chidamide, pyroxamide",2.44733178388781,0.943095148663527,TRUE +"HCC15","Pearson.est","histamine receptor antagonist",0.23387,0.551,0.961,915,1,"chloropyramine, cyproheptadine, epinastine, astemizole, tecastemizole, ICI.162846, ebastine, lafutidine, tiotidine, cimetidine, pheniramine, zolantidine, levocetirizine",0.0172766123314547,0,FALSE +"HCC15","Pearson.est","HMGCR inhibitor",-0.45697,-1.35,0.158,1373,0.481,"lovastatin, simvastatin",0.801342913045577,0.317854923626168,FALSE +"HCC15","Pearson.est","HSP inhibitor",0.52679,1.26,0.188,492,0.518,"NMS.E973, SNX.5422, SNX.2112, KW.2478, NVP.AUY922, BIIB021, PU.H71, ganetespib",0.72584215073632,0.285670240254767,FALSE +"HCC15","Pearson.est","JAK inhibitor",0.41719,0.983,0.504,563,0.836,"lestaurtinib, WHI.P154, AZ960, baricitinib, tozasertib, AT.9283, pacritinib, TG.101348, TG.02, PRT062070, TG.101209, LY2784544",0.297569463554475,0.0777937225609836,FALSE +"HCC15","Pearson.est","KIT inhibitor",0.25092,0.595,0.93,718,1,"OSI.930, regorafenib, pazopanib, sunitinib, motesanib, midostaurin, masitinib, vatalanib, cediranib, lenvatinib, sorafenib",0.0315170514460649,0,FALSE +"HCC15","Pearson.est","MDM inhibitor",-0.40695,-1.15,0.257,1251,0.719,"RITA, AMG.232, CGM097",0.590066876668705,0.143271109617117,FALSE +"HCC15","Pearson.est","MEK inhibitor",-0.37439,-1.12,0.342,535,0.649,"PD.318088, U.0126, PD.198306, MEK162, arctigenin, MEK1.2.inhibitor, PD.98059, PD.0325901, nobiletin, BIX.02188, TAK.733, PD.184352, AZD8330, Ro.4987655, selumetinib, cobimetinib, refametinib, trametinib, AS.703026",0.465973893943865,0.187755303199631,FALSE +"HCC15","Pearson.est","MET inhibitor",0.3856,0.918,0.58,57,0.931,"AMG458",0.236572006437063,0.0310503190186574,FALSE +"HCC15","Pearson.est","microtubule inhibitor",0.64551,1.52,0.0473,320,0.442,"vinblastine, vinflunine, D.64131, cabazitaxel, podophyllotoxin, colchicine, triclabendazole",1.32513885926219,0.354577730650908,FALSE +"HCC15","Pearson.est","mTOR inhibitor",0.47276,1.12,0.318,522,0.662,"GSK2126458, PF.04691502, deforolimus, PF.05212384, OSI.027, PI.103, PKI.179, AZD8055, SB.2343, torin.1, AZD2014, ku.0063794, PP242, XL388",0.497572880015567,0.1791420105603,FALSE +"HCC15","Pearson.est","NFkB pathway inhibitor",0.55577,1.31,0.146,479,0.575,"EVP4593, curcumin, parthenolide, BAY.11.7082, bindarit, Ro.106.9920, tyloxapol, betulinic.acid",0.835647144215563,0.24033215531037,FALSE +"HCC15","Pearson.est","opioid receptor agonist",-0.24202,-0.686,0.851,349,0.891,"trimebutine, spiradoline, salvinorin.a, BW.180C, cebranopadol, ADL5859",0.0700704399154121,0.0501222959631252,FALSE +"HCC15","Pearson.est","p38 MAPK inhibitor",0.44171,1.04,0.421,325,0.755,"talmapimod, SB.239063",0.375717904164332,0.122053048370812,FALSE +"HCC15","Pearson.est","PARP inhibitor",0.54456,1.28,0.16,327,0.552,"talazoparib, niraparib, PJ.34, AZD2461, olaparib",0.795880017344075,0.258060922270801,FALSE +"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.22912,0.53,0.964,745,1,"dovitinib, axitinib, regorafenib, pazopanib, SU014813, sunitinib, nintedanib, motesanib, trapidil, masitinib, vatalanib, lenvatinib, sorafenib, linifanib, crenolanib",0.0159229660971692,0,FALSE +"HCC15","Pearson.est","phosphatase inhibitor",0.5427,1.28,0.155,419,0.552,"CID.5458317, sodium.stibogluconate, menadione, mycophenolate.mofetil, bis.maltolato.oxovanadium.IV., alexidine",0.809668301829709,0.258060922270801,FALSE +"HCC15","Pearson.est","phosphodiesterase inhibitor",0.36838,0.862,0.669,700,0.926,"enoximone, avanafil, papaverine, cilostamide, GSK256066, EMD.53998, anagrelide",0.174573882232177,0.0333890133180656,FALSE +"HCC15","Pearson.est","PI3K inhibitor",0.50487,1.19,0.249,477,0.586,"CUDC.907, GSK2126458, PF.04691502, PF.05212384, buparlisib, BGT226, AZD6482, PI.103, PKI.179, taselisib, pilaralisib, GDC.0941, SB.2343, ZSTK.474, YM.201636",0.603800652904264,0.232102383981909,FALSE +"HCC15","Pearson.est","PLK inhibitor",0.8626,2.03,0,205,0.00767,"BI.2536, volasertib, rigosertib, NMS.1286937, HMN.214, GW.843682X, GSK461364",Inf,2.11520463605102,TRUE +"HCC15","Pearson.est","potassium channel blocker",-0.32247,-0.943,0.523,465,0.793,"mepivacaine, ML133, dofetilide, oleoylethanolamide, meglitinide, ibutilide",0.281498311132726,0.100726812682396,FALSE +"HCC15","Pearson.est","PPAR receptor agonist",0.39903,0.937,0.549,365,0.915,"ciprofibrate, pterostilbene",0.260427655549908,0.0385789059335517,FALSE +"HCC15","Pearson.est","progesterone receptor agonist",0.3528,0.836,0.701,297,0.951,"tanaproget, danazol",0.154281982033341,0.0218194830625861,FALSE +"HCC15","Pearson.est","proteasome inhibitor",0.28564,0.67,0.892,690,1,"MG.132, carfilzomib, ONX.0914, oprozomib, delanzomib",0.0496351456238769,0,FALSE +"HCC15","Pearson.est","protein synthesis inhibitor",0.66551,1.59,0.0337,170,0.317,"anguidine, azomycin..2.nitroimidazole., homoharringtonine, bruceantin, thiostrepton, puromycin, tedizolid.phosphate, harringtonine",1.47237009912866,0.498940737782249,FALSE +"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.3562,0.831,0.713,607,0.939,"tyrphostin.A9, mubritinib, PP.121, NVP.TAE226, CP.724714",0.146910470148134,0.0273344077338891,FALSE +"HCC15","Pearson.est","RAF inhibitor",0.56771,1.33,0.13,508,0.557,"TAK.632, RAF265, regorafenib, PLX.4720, AZ.628, GDC.0879, dabrafenib, SB.590885, CEP.32496",0.886056647693163,0.254144804826271,FALSE +"HCC15","Pearson.est","RET tyrosine kinase inhibitor",-0.26818,-0.766,0.76,1433,0.948,"vandetanib",0.119186407719209,0.0231916626619338,FALSE +"HCC15","Pearson.est","retinoid receptor agonist",0.55668,1.28,0.164,618,0.552,"adarotene, fenretinide, bexarotene, adapalene, AM.580, CD.437, LE.135",0.785156151952302,0.258060922270801,FALSE +"HCC15","Pearson.est","ribonucleotide reductase inhibitor",0.50173,1.18,0.269,429,0.588,"fludarabine.phosphate, LY2334737, clofarabine, pentostatin, triapine",0.570247719997592,0.230622673923862,FALSE +"HCC15","Pearson.est","serotonin receptor agonist",0.57019,1.33,0.131,98,0.557,"aripiprazole, pardoprunox",0.882728704344236,0.254144804826271,FALSE +"HCC15","Pearson.est","serotonin receptor antagonist",0.46909,1.1,0.358,370,0.666,"aripiprazole, SB.200646, sertindole, lurasidone, lerisetron",0.446116973356126,0.176525770829699,FALSE +"HCC15","Pearson.est","sodium channel blocker",0.28152,0.662,0.862,609,1,"brivaracetam, benzethonium, lappaconite, mexiletine, mepivacaine, triamterene, quinidine",0.0644927341752872,0,FALSE +"HCC15","Pearson.est","src inhibitor",-0.5108,-1.42,0.117,1445,0.521,"saracatinib, dasatinib",0.931814138253838,0.283162276700476,FALSE +"HCC15","Pearson.est","sterol demethylase inhibitor",-0.46603,-1.38,0.144,1314,0.507,"lanoconazole, ketoconazole, sulconazole, terconazole",0.84163750790475,0.294992040666664,FALSE +"HCC15","Pearson.est","TGF beta receptor inhibitor",0.24709,0.582,0.95,708,1,"adaprev, D.4476, LY2109761, SB.431542",0.0222763947111523,0,FALSE +"HCC15","Pearson.est","thymidylate synthase inhibitor",0.49429,1.15,0.297,493,0.613,"doxifluridine, raltitrexed, trifluridine, carmofur",0.527243550682788,0.212539525481585,FALSE +"HCC15","Pearson.est","topoisomerase inhibitor",0.53439,1.26,0.171,467,0.518,"doxorubicin, valrubicin, epirubicin, daunorubicin, etoposide, dexrazoxane, teniposide, beta.lapachone, voreloxin, etoposide.phosphate, nemorubicin, mitoxantrone, topotecan, SN.38, irinotecan, genz.644282, amonafide, camptothecin",0.767003889607846,0.285670240254767,FALSE +"HCC15","Pearson.est","tubulin polymerization inhibitor",0.73581,1.74,0.0159,285,0.114,"taltobulin, vincristine, vinorelbine, albendazole, vinblastine, fosbretabulin, vindesine, parbendazole, dolastatin.10, nocodazole, fenbendazole, ABT.751, flubendazole, BNC105, KX2.391, CYT.997, plinabulin, paclitaxel, combretastatin.A.4, verubulin, mebendazole, podophyllotoxin, oxibendazole",1.79860287567955,0.943095148663527,TRUE +"HCC15","Pearson.est","tyrosine kinase inhibitor",0.32283,0.759,0.797,211,1,"tyrphostin.A9, GTP.14564, regorafenib, tivantinib, bafetinib, UNC2250, mubritinib",0.0985416786038876,0,FALSE +"HCC15","Pearson.est","VEGFR inhibitor",0.27293,0.644,0.896,433,1,"OSI.930, dovitinib, RAF265, axitinib, regorafenib, pazopanib, PD.173074, semaxanib, ENMD.2076, MK.2461, SU014813, sunitinib",0.0476919903378748,0,FALSE +"HCC15","Pearson.est","vitamin D receptor agonist",-0.65771,-2.02,0.0194,1153,0.119,"tacalcitol, paricalcitol, ercalcitriol, alfacalcidol, doxercalciferol",1.71219827006977,0.924453038607469,TRUE +"HCC44","Pearson.est","EGFR inhibitor",0.65137,1.96,0,105,0.0897,"tucatinib, poziotinib, osimertinib, AZD8931, dacomitinib, ARRY.334543, CNX.2006, CUDC.101, BMS.599626, CP.724714, canertinib, BMS.690514, afatinib, WZ8040, lapatinib, neratinib, gefitinib, WZ.4002",Inf,1.04720755695591,TRUE +"HCC44","Pearson.est","Abl kinase inhibitor",-0.62716,-1.49,0.0534,1051,0.411,"ponatinib, metatinib, GZD824, nilotinib, flumatinib, dasatinib, tozasertib, KW.2449, bosutinib",1.27245874297144,0.386158178123931,FALSE +"HCC44","Pearson.est","acetylcholine receptor agonist",-0.50033,-1.2,0.231,848,0.695,"nicotine, tremorine, xanomeline, pilocarpine",0.636388020107856,0.158015195409886,FALSE +"HCC44","Pearson.est","acetylcholine receptor antagonist",-0.37815,-0.903,0.592,1064,0.87,"iododexetimide, methscopolamine",0.22767829327708,0.0604807473813815,FALSE +"HCC44","Pearson.est","adenosine receptor antagonist",0.62099,1.86,0,40,0.0988,"CGS.15943, MRS.1220, SCH.58261",Inf,1.00524305541237,TRUE +"HCC44","Pearson.est","adrenergic receptor agonist",-0.47449,-1.14,0.293,1059,0.662,"isoetharine, A61603, isoxsuprine, norepinephrine, epinephrine, buphenine, clenbuterol",0.533132379645891,0.1791420105603,FALSE +"HCC44","Pearson.est","adrenergic receptor antagonist",-0.35574,-0.836,0.695,1165,0.882,"vincamine, propranolol, carvedilol, levobunolol, idazoxan",0.158015195409886,0.0545314148681803,FALSE +"HCC44","Pearson.est","AKT inhibitor",0.39214,1.19,0.23,133,0.595,"uprosertib, GDC.0068, GSK2110183, MK.2206",0.638272163982407,0.22548303427145,FALSE +"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.46079,-1.1,0.327,1062,0.628,"AZD3463, AP26113, crizotinib, lorlatinib",0.485452247339714,0.202040356262804,FALSE +"HCC44","Pearson.est","androgen receptor antagonist",-0.51779,-1.23,0.211,994,0.642,"bicalutamide, flutamide, nilutamide, cyproterone.acetate",0.675717544702307,0.192464971931147,FALSE +"HCC44","Pearson.est","antioxidant",-0.4681,-1.12,0.305,675,0.642,"trolox, benfotiamine, rutin, taurine, chlorogenic.acid, mesna",0.515700160653214,0.192464971931147,FALSE +"HCC44","Pearson.est","AP inhibitor",-0.37328,-0.897,0.611,651,0.863,"idronoxil, birinapant, GDC.0152, LCL.161",0.213958789757446,0.0639892042847904,FALSE +"HCC44","Pearson.est","ATPase inhibitor",-0.51157,-1.23,0.206,1358,0.642,"ouabain, digitoxigenin, digitoxin",0.686132779630847,0.192464971931147,FALSE +"HCC44","Pearson.est","Aurora kinase inhibitor",-0.45528,-1.09,0.357,1293,0.632,"alisertib, MK.8745, PF.03814735, tozasertib, KW.2449, MK.5108, hesperadin",0.447331783887807,0.199282921717615,FALSE +"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.52885,-1.29,0.158,948,0.615,"josamycin, tilmicosin, valnemulin, tedizolid, dirithromycin",0.801342913045577,0.211124884224583,FALSE +"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.55546,-1.32,0.13,1004,0.707,"norfloxacin, lomefloxacin, novobiocin, sparfloxacin, finafloxacin",0.886056647693163,0.150580586203101,FALSE +"HCC44","Pearson.est","BCL inhibitor",0.26875,0.824,0.667,1061,0.907,"ABT.737, oridonin, HA14.1, venetoclax, navitoclax, obatoclax, gossypol, TW.37",0.175874166083451,0.0423927129399047,FALSE +"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.68021,-1.63,0.0151,1051,0.253,"ponatinib, metatinib, GZD824, nilotinib, flumatinib, dasatinib, tozasertib, bosutinib",1.82102305270683,0.596879478824182,FALSE +"HCC44","Pearson.est","benzodiazepine receptor agonist",-0.25111,-0.597,0.939,999,0.985,"ZK.93423, lorazepam, CGS.20625",0.0273344077338891,0.00656376950238827,FALSE +"HCC44","Pearson.est","bromodomain inhibitor",0.49098,1.53,0.0803,740,0.263,"I.BET151, OTX015, PFI.1, JQ1...., I.BET.762, bromosporine",1.09528445472132,0.580044251510242,FALSE +"HCC44","Pearson.est","calcium channel blocker",0.25939,0.783,0.729,1075,0.923,"efonidipine.monoethanolate, fendiline, SR.33805, mibefradil, SKF.96365, pranidipine, penfluridol, tetrandrine, cinnarazine, carboxyamidotriazole",0.137272471682025,0.0347982989740879,FALSE +"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.31789,-0.762,0.786,686,0.943,"PF.04136309, navarixin, MK.0812, UNBS.5162, RS.504393",0.104577453960592,0.0254883072626717,FALSE +"HCC44","Pearson.est","CDK inhibitor",-0.49302,-1.17,0.263,1047,0.633,"PHA.793887, CR8..R., JNJ.7706621, R547, BMS.265246, kenpaullone, aminopurvalanol.a, abemaciclib, alvocidib, PHA.848125, palbociclib, AZD5438",0.580044251510242,0.198596289982645,FALSE +"HCC44","Pearson.est","CHK inhibitor",-0.48915,-1.17,0.269,1246,0.633,"AZD7762, SCH.900776, LY2606368",0.570247719997592,0.198596289982645,FALSE +"HCC44","Pearson.est","cyclooxygenase inhibitor",-0.25133,-0.607,0.935,611,0.995,"piroxicam, meloxicam, acetylsalicylsalicylic.acid, amfenac, FK.3311, metoxibutropate, phenylbutazone, FR.122047, aspirin, phenazone, tepoxalin, ramifenazone, ketoprofen, suxibuzone, indoprofen",0.0291883891274822,0.00217691925427455,FALSE +"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.46565,-1.12,0.311,671,0.642,"itraconazole, metyrapone, morin, clotrimazole, PF.4981517, eplerenone, cobicistat",0.507239610973163,0.192464971931147,FALSE +"HCC44","Pearson.est","DNA alkylating agent",-0.50519,-1.19,0.239,820,0.634,"streptozotocin, ifosfamide, TH.302, dacarbazine, mitomycin.c, dianhydrogalactitol, melphalan, satraplatin, temozolomide, carmustine, cisplatin, carboplatin",0.621602099051862,0.197910742118267,FALSE +"HCC44","Pearson.est","DNA inhibitor",-0.40504,-0.974,0.506,807,0.819,"primaquine, nimorazole, tirapazamine, sangivamycin, teroxirone, chlorambucil, melphalan, valrubicin, carmustine, carboplatin",0.295849483160201,0.0867160982395816,FALSE +"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.48851,-1.16,0.289,1364,0.636,"decitabine",0.539102157243452,0.196542884351586,FALSE +"HCC44","Pearson.est","DNA polymerase inhibitor",-0.45867,-1.11,0.32,1111,0.625,"idoxuridine, trifluridine, foscarnet",0.494850021680094,0.204119982655925,FALSE +"HCC44","Pearson.est","DNA synthesis inhibitor",-0.54524,-1.3,0.152,924,0.625,"artesunate, artemisinin, mitomycin.c, nelarabine, anisomycin, cisplatin, floxuridine, CB.10.277, cyclocytidine",0.818156412055227,0.204119982655925,FALSE +"HCC44","Pearson.est","dopamine receptor antagonist",-0.20333,-0.486,0.985,1226,1,"isofloxythepin, piperacetazine, raclopride",0.00656376950238827,0,FALSE +"HCC44","Pearson.est","estrogen receptor agonist",-0.50864,-1.23,0.196,894,0.642,"estradiol.cypionate, estrone, estradiol, ethinyl.estradiol, PPT",0.707743928643524,0.192464971931147,FALSE +"HCC44","Pearson.est","estrogen receptor antagonist",0.36612,1.13,0.243,170,0.643,"raloxifene, danazol",0.614393726401688,0.191789027075778,FALSE +"HCC44","Pearson.est","FGFR inhibitor",0.36231,1.09,0.344,927,0.657,"PD.173074, orantinib, lenvatinib, dovitinib, erdafitinib, lucitanib, AZD4547, regorafenib, nintedanib, MK.2461",0.46344155742847,0.182434630440219,FALSE +"HCC44","Pearson.est","FLT3 inhibitor",-0.44517,-1.07,0.377,822,0.659,"lestaurtinib, tandutinib, pacritinib, quizartinib, tyrphostin.AG.1296, ponatinib, midostaurin, tozasertib, KW.2449, gilteritinib",0.423658649794207,0.18111458540599,FALSE +"HCC44","Pearson.est","glucocorticoid receptor agonist",-0.24454,-0.578,0.96,866,0.98,"dexamethasone.acetate, prednisolone.acetate, halobetasol.propionate, beclomethasone.dipropionate, fluorometholone, fluocinolone.acetonide, methylprednisolone, difluprednate, flumethasone, fluticasone.propionate",0.0177287669604316,0.00877392430750515,FALSE +"HCC44","Pearson.est","glutamate receptor antagonist",0.23611,0.681,0.883,196,0.907,"CGP.37849, MTPG, CPP, IEM1754",0.0540392964224314,0.0423927129399047,FALSE +"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.38344,-0.925,0.576,892,0.865,"AZD2858, TWS.119, CHIR.99021, kenpaullone, tideglusib",0.239577516576788,0.0629838925351858,FALSE +"HCC44","Pearson.est","growth factor receptor inhibitor",-0.47499,-1.13,0.3,822,0.662,"lestaurtinib, GSK1904529A, danusertib, AZD3463, GSK1838705A, PHA.848125",0.522878745280338,0.1791420105603,FALSE +"HCC44","Pearson.est","HCV inhibitor",-0.59475,-1.43,0.0761,1140,0.467,"Ro.9187, daclatasvir, mericitabine",1.11861534322943,0.330683119433888,FALSE +"HCC44","Pearson.est","HDAC inhibitor",0.39447,1.21,0.223,789,0.635,"scriptaid, SB.939, R306465, vorinostat, PCI.24781, M.344, JNJ.26481585, ACY.1215, entinostat, givinostat, nexturastat.a, RGFP966, tacedinaline, NSC.3852, romidepsin, pyroxamide, AR.42, panobinostat, dacinostat, RG2833, chidamide, resminostat, mocetinostat, belinostat",0.651695136951839,0.197226274708024,FALSE +"HCC44","Pearson.est","histamine receptor antagonist",-0.29664,-0.721,0.829,1153,0.942,"tiotidine, cimetidine, nizatidine, BF2.649, pheniramine",0.0814454694497265,0.0259490972071227,FALSE +"HCC44","Pearson.est","HMGCR inhibitor",-0.78833,-1.87,0.00116,1217,0.128,"simvastatin, atorvastatin, pitavastatin, fluvastatin, mevastatin",2.93554201077308,0.892790030352132,TRUE +"HCC44","Pearson.est","HSP inhibitor",-0.70256,-1.68,0.0127,1162,0.206,"XL888, NMS.E973, SNX.5422, SNX.2112, BIIB021, ganetespib, NVP.AUY922, PU.H71",1.89619627904404,0.686132779630847,TRUE +"HCC44","Pearson.est","JAK inhibitor",-0.43277,-1.03,0.432,910,0.711,"AZD1480, pacritinib, TG.101209, CEP.33779, baricitinib, ruxolitinib, AZ960, filgotinib, tozasertib, WHI.P154",0.364516253185088,0.148130399270234,FALSE +"HCC44","Pearson.est","KIT inhibitor",-0.36232,-0.862,0.676,718,0.873,"cediranib, pazopanib, motesanib, regorafenib, tandutinib, telatinib, KI.8751, midostaurin, dasatinib",0.170053304058364,0.0589857562944303,FALSE +"HCC44","Pearson.est","MDM inhibitor",0.2337,0.671,0.848,1111,0.873,"RITA, serdemetan, idasanutlin, AMG.232, CGM097, nutlin.3",0.0716041477432862,0.0589857562944303,FALSE +"HCC44","Pearson.est","MEK inhibitor",-0.36344,-0.875,0.644,602,0.868,"PD.198306, AS.703026, PD.318088, AZD8330, TAK.733, U.0126, PD.98059, trametinib, MEK162, arctigenin, PD.0325901, nobiletin, refametinib, Ro.4987655, PD.184352",0.191114132640188,0.0614802748235081,FALSE +"HCC44","Pearson.est","MET inhibitor",-0.7618,-1.81,0.00462,1332,0.128,"PF.04217903, PHA.665752, LY2801653",2.33535802444387,0.892790030352132,TRUE +"HCC44","Pearson.est","microtubule inhibitor",-0.5274,-1.26,0.172,799,0.663,"triclabendazole, cytochalasin.b, secnidazole, podophyllotoxin, cabazitaxel, vinflunine, vinblastine, D.64131",0.764471553092451,0.178486471595227,FALSE +"HCC44","Pearson.est","mTOR inhibitor",0.23451,0.706,0.854,1115,0.982,"PF.05212384, OSI.027, AZD2014, WYE.125132, XL388, GSK2126458, PF.04691502, SB.2343, PKI.179, temsirolimus, everolimus, PI.103, torin.2, WYE.354, sirolimus, GDC.0980, AZD8055, LY303511, voxtalisib, ku.0063794, torin.1, deforolimus, PP242, MLN0128, WAY.600, NVP.BEZ235, LY3023414, palomid.529",0.068542129310995,0.00788851221305034,FALSE +"HCC44","Pearson.est","NFkB pathway inhibitor",0.33098,1.02,0.369,111,0.74,"tyloxapol, parthenolide...., Ro.106.9920",0.43297363384094,0.130768280269024,FALSE +"HCC44","Pearson.est","opioid receptor agonist",-0.63672,-1.53,0.0356,1224,0.365,"salvinorin.a, trimebutine, spiradoline",1.44855000202712,0.437707135543525,FALSE +"HCC44","Pearson.est","p38 MAPK inhibitor",0.22831,0.683,0.862,1119,0.956,"talmapimod, TAK.715, skepinone.l, SB.239063, VX.702, SB.242235, CMPD.1",0.0644927341752872,0.0195421077238999,FALSE +"HCC44","Pearson.est","PARP inhibitor",-0.4962,-1.19,0.259,927,0.634,"AZD2461, AG.14361, niraparib, E7449, talazoparib, olaparib",0.586700235918748,0.197910742118267,FALSE +"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.40254,-0.969,0.52,780,0.809,"pazopanib, motesanib, trapidil, regorafenib, tandutinib, nintedanib, telatinib, ponatinib, KI.8751, dasatinib, crenolanib, CP.673451",0.283996656365201,0.0920514783877277,FALSE +"HCC44","Pearson.est","phosphatase inhibitor",-0.26797,-0.638,0.919,906,0.989,"BVT.948, mycophenolic.acid, AS.1949490, GSK2830371",0.0366844886138887,0.0048037084028206,FALSE +"HCC44","Pearson.est","phosphodiesterase inhibitor",-0.38736,-0.929,0.582,1121,0.877,"EMD.53998, YM.976, zardaverine",0.235077015350112,0.0570004066339595,FALSE +"HCC44","Pearson.est","PI3K inhibitor",0.26572,0.836,0.594,108,0.945,"taselisib, PF.05212384, CUDC.907, alpelisib, pilaralisib, CH5132799",0.226213555018806,0.0245681914907371,FALSE +"HCC44","Pearson.est","PLK inhibitor",-0.58084,-1.4,0.0959,930,0.506,"NMS.1286937, BI.2536, GW.843682X, GSK461364, volasertib, rigosertib",1.01818139282934,0.295849483160201,FALSE +"HCC44","Pearson.est","potassium channel blocker",-0.73145,-1.75,0.00804,1158,0.152,"meglitinide, dofetilide, oleoylethanolamide, ML133, ibutilide",2.09474395125155,0.818156412055227,TRUE +"HCC44","Pearson.est","PPAR receptor agonist",0.30997,0.909,0.518,128,0.853,"pterostilbene, S26948",0.285670240254767,0.069050968832477,FALSE +"HCC44","Pearson.est","progesterone receptor agonist",-0.31466,-0.761,0.794,1180,0.927,"nomegestrol.acetate, dienogest",0.100179497572904,0.0329202658555029,FALSE +"HCC44","Pearson.est","proteasome inhibitor",-0.45951,-1.11,0.316,1200,0.625,"bortezomib, MG.132, ixazomib",0.500312917381596,0.204119982655925,FALSE +"HCC44","Pearson.est","protein synthesis inhibitor",-0.33869,-0.804,0.757,1301,0.915,"emetine, cycloheximide, mercaptopurine",0.120904120499927,0.0385789059335517,FALSE +"HCC44","Pearson.est","protein tyrosine kinase inhibitor",0.3213,0.957,0.51,48,0.816,"BMS.599626, CP.724714",0.292429823902064,0.0883098412461389,FALSE +"HCC44","Pearson.est","RAF inhibitor",-0.33067,-0.787,0.745,850,0.924,"regorafenib, PLX.4720, GDC.0879, LGX818, RAF265",0.127843727251707,0.0343280287798933,FALSE +"HCC44","Pearson.est","RET tyrosine kinase inhibitor",-0.27527,-0.657,0.903,641,0.99,"apatinib, regorafenib, cabozantinib",0.0443122496864942,0.00436480540245009,FALSE +"HCC44","Pearson.est","retinoid receptor agonist",0.53751,1.69,0.0217,152,0.173,"adarotene, fenretinide, CD.437, bexarotene",1.66354026615147,0.761953896871205,TRUE +"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.54032,-1.3,0.16,1212,0.625,"triapine, gemcitabine, fludarabine.phosphate, clofarabine",0.795880017344075,0.204119982655925,FALSE +"HCC44","Pearson.est","serotonin receptor agonist",-0.49721,-1.19,0.217,1258,0.634,"aripiprazole, SR.57227A",0.66354026615147,0.197910742118267,FALSE +"HCC44","Pearson.est","serotonin receptor antagonist",-0.36528,-0.885,0.626,953,0.868,"lerisetron, SB.228357, SB.216641, pirenperone, aripiprazole, RS.16566",0.20342566678957,0.0614802748235081,FALSE +"HCC44","Pearson.est","sodium channel blocker",-0.36466,-0.857,0.673,1007,0.863,"ajmaline, butamben, oxcarbazepine, quinidine, cibenzoline",0.171984935776023,0.0639892042847904,FALSE +"HCC44","Pearson.est","src inhibitor",-0.59672,-1.43,0.06,1340,0.467,"dasatinib, bosutinib, PP.2",1.22184874961636,0.330683119433888,FALSE +"HCC44","Pearson.est","sterol demethylase inhibitor",-0.38134,-0.92,0.561,592,0.855,"ketoconazole, sulconazole, posaconazole, lanoconazole, chlormidazole",0.251037138743839,0.0680338852718274,FALSE +"HCC44","Pearson.est","TGF beta receptor inhibitor",0.83634,2.45,0,242,0.00915,"SB.431542, SB.525334, LY2109761, adaprev, repsox, D.4476",Inf,2.03857890593355,TRUE +"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.53981,-1.3,0.135,1025,0.625,"ftorafur, trifluridine, doxifluridine, raltitrexed",0.869666231504994,0.204119982655925,FALSE +"HCC44","Pearson.est","topoisomerase inhibitor",-0.66926,-1.6,0.0289,1168,0.265,"valrubicin, irinotecan, amonafide, camptothecin, nemorubicin, etoposide.phosphate, mitoxantrone, exatecan.mesylate, etoposide, voreloxin, amsacrine, teniposide, genz.644282, idarubicin, topotecan, rubitecan, TAS.103, SN.38",1.53910215724345,0.576754126063192,FALSE +"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.44242,-1.05,0.408,1071,0.686,"KX2.391, vindesine, parbendazole, podophyllotoxin, verubulin, paclitaxel, docetaxel, epothilone.b, fosbretabulin, vinblastine, epothilone.d, BNC105",0.38933983691012,0.163675884293248,FALSE +"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.32014,-0.751,0.817,1065,0.923,"tivantinib, AMG.208, cabozantinib, UNC2250, NVP.TAE226, aminopurvalanol.a, dasatinib",0.0877779434675845,0.0347982989740879,FALSE +"HCC44","Pearson.est","VEGFR inhibitor",-0.15056,-0.362,1,827,0.999,"motesanib, regorafenib, nintedanib, MGCD.265, MK.2461, telatinib, KI.8751, foretinib, cabozantinib, RAF265, SAR131675",0,0.000434511774017692,FALSE +"HCC44","Pearson.est","vitamin D receptor agonist",0.47351,1.5,0.0606,113,0.25,"maxacalcitol, paricalcitol",1.21752737583371,0.602059991327962,FALSE +"H1299","Pearson.est","EGFR inhibitor",0.84454,2.34,0,64,0.00999,"osimertinib, BMS.690514, afatinib, AZD8931, BMS.599626, canertinib, poziotinib, lapatinib, ARRY.334543, tucatinib, dacomitinib, AST.1306, CUDC.101, neratinib, erlotinib, WZ.4002, WZ8040, pelitinib, PD.168393, XL.647, gefitinib, BIBU.1361, CP.724714, vandetanib, PD.153035, AEE788, rociletinib",Inf,2.00043451177402,TRUE +"H1299","Pearson.est","Abl kinase inhibitor",-0.40379,-0.964,0.513,1111,0.751,"metatinib, ponatinib, tozasertib, GZD824, nilotinib",0.289882634888184,0.124360062995832,FALSE +"H1299","Pearson.est","acetylcholine receptor agonist",-0.27613,-0.67,0.865,602,1,"tremorine, nicotine, pilocarpine, oxiracetam, xanomeline",0.0629838925351858,0,FALSE +"H1299","Pearson.est","acetylcholine receptor antagonist",-0.52362,-1.25,0.198,933,0.468,"darifenacin, diphemanil, methscopolamine, iododexetimide",0.703334809738469,0.329754146925876,FALSE +"H1299","Pearson.est","adenosine receptor antagonist",0.66956,1.8,0.017,37,0.105,"CGS.15943, MRS.1220, SCH.58261",1.76955107862173,0.978810700930062,TRUE +"H1299","Pearson.est","adrenergic receptor agonist",-0.24015,-0.579,0.936,827,0.974,"buphenine, lidamidine, norepinephrine, clenbuterol, xylazine",0.0287241512618947,0.0114410431213845,FALSE +"H1299","Pearson.est","adrenergic receptor antagonist",-0.27809,-0.659,0.868,851,0.994,"naftidrofuryl, propranolol, metoprolol, oxprenolol, levobunolol, vincamine, carvedilol, idazoxan",0.0614802748235081,0.00261361560268669,FALSE +"H1299","Pearson.est","AKT inhibitor",0.71864,1.94,0.0157,125,0.0844,"GDC.0068, AZD5363, GSK2110183, uprosertib, CCT128930",1.80410034759077,1.07365755337434,TRUE +"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.21507,-0.521,0.979,1085,0.972,"crizotinib, lorlatinib",0.00921730819686218,0.0123337350737254,FALSE +"H1299","Pearson.est","androgen receptor antagonist",-0.4668,-1.12,0.328,803,0.586,"cyproterone.acetate, flutamide, nilutamide",0.484126156288321,0.232102383981909,FALSE +"H1299","Pearson.est","antioxidant",0.35298,1.01,0.421,939,0.658,"trolox, benfotiamine, mesna, taurine, rutin, chlorogenic.acid",0.375717904164332,0.181774106386044,FALSE +"H1299","Pearson.est","AP inhibitor",-0.6823,-1.65,0.0214,1192,0.201,"birinapant, LCL.161, GDC.0152, idronoxil",1.66958622665081,0.696803942579511,TRUE +"H1299","Pearson.est","ATPase inhibitor",-0.77125,-1.84,0.00381,1256,0.0567,"thonzonium, oligomycin.a, evodiamine, ouabain, digitoxin, digitoxigenin, k.strophanthidin, digoxin",2.41907502432438,1.24641694110709,TRUE +"H1299","Pearson.est","Aurora kinase inhibitor",-0.59139,-1.41,0.101,997,0.334,"KW.2449, CCT137690, GSK1070916, aurora.a.inhibitor.i, alisertib, SNS.314, MK.8745, TAK.901, AMG900, PF.03814735, barasertib.HQPA, barasertib, hesperadin, danusertib, tozasertib, MK.5108",0.995678626217357,0.476253533188435,FALSE +"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.41408,-1,0.474,806,0.718,"josamycin, tilmicosin, radezolid, tedizolid, valnemulin",0.324221658325915,0.1438755557577,FALSE +"H1299","Pearson.est","bacterial DNA gyrase inhibitor",-0.41106,-0.987,0.483,1223,0.725,"sparfloxacin, lomefloxacin",0.316052869248488,0.139661993429006,FALSE +"H1299","Pearson.est","BCL inhibitor",-0.31768,-0.75,0.785,1140,0.958,"TW.37, gossypol",0.105130343254747,0.0186344909214556,FALSE +"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.62225,-1.48,0.0533,1111,0.319,"metatinib, ponatinib, tozasertib, GZD824, nilotinib",1.27327279097343,0.496209316942819,FALSE +"H1299","Pearson.est","benzodiazepine receptor agonist",-0.25011,-0.596,0.941,869,1,"ZK.93423, indiplon, CGS.20625, bentazepam",0.0264103765727431,0,FALSE +"H1299","Pearson.est","bromodomain inhibitor",0.36333,0.999,0.38,187,0.632,"PFI.1, I.BET151",0.42021640338319,0.199282921717615,FALSE +"H1299","Pearson.est","calcium channel blocker",-0.29862,-0.718,0.832,1302,0.982,"penfluridol, carboxyamidotriazole",0.0798766737092761,0.00788851221305034,FALSE +"H1299","Pearson.est","CC chemokine receptor antagonist",-0.3578,-0.853,0.653,992,0.915,"MK.0812, SB.225002, UNBS.5162",0.185086818724926,0.0385789059335517,FALSE +"H1299","Pearson.est","CDK inhibitor",-0.35365,-0.845,0.666,820,0.909,"alvocidib, AT.7519, aminopurvalanol.a, P276.00, AZD5438, BMS.387032, kenpaullone, BMS.265246, palbociclib, abemaciclib, dinaciclib, R547, PHA.848125, PHA.793887",0.176525770829699,0.0414361167780325,FALSE +"H1299","Pearson.est","CHK inhibitor",-0.31622,-0.768,0.772,819,0.952,"AZD7762, SB.218078, SCH.900776, LY2606368",0.112382699664264,0.0213630516155257,FALSE +"H1299","Pearson.est","cyclooxygenase inhibitor",-0.23908,-0.566,0.946,917,0.966,"amfenac, piroxicam, sulfasalazine, AM.404, indoprofen, metoxibutropate, suxibuzone, tepoxalin",0.0241088635982073,0.0150228735845067,FALSE +"H1299","Pearson.est","cytochrome P450 inhibitor",-0.55642,-1.34,0.127,926,0.387,"itraconazole, eplerenone, clotrimazole, cobicistat, metyrapone",0.896196279044043,0.412289034981089,FALSE +"H1299","Pearson.est","DNA alkylating agent",-0.47786,-1.13,0.295,772,0.602,"streptozotocin, satraplatin, mitomycin.c, cyclophosphamide, estramustine, TH.302, temozolomide, melphalan, carmustine, dianhydrogalactitol, carboplatin, cisplatin",0.530177984021837,0.220403508742175,FALSE +"H1299","Pearson.est","DNA inhibitor",-0.55085,-1.32,0.153,1157,0.405,"melphalan, sangivamycin, carmustine, carboplatin, chlorambucil, valrubicin",0.815308569182401,0.392544976785331,FALSE +"H1299","Pearson.est","DNA methyltransferase inhibitor",0.321,0.859,0.621,171,0.748,"SGI.1027, fdcyd, azacitidine",0.20690839982342,0.126098402135539,FALSE +"H1299","Pearson.est","DNA polymerase inhibitor",-0.56752,-1.34,0.131,1127,0.387,"trifluridine, cephalomannine, foscarnet, menadione",0.882728704344236,0.412289034981089,FALSE +"H1299","Pearson.est","DNA synthesis inhibitor",-0.49073,-1.18,0.255,817,0.554,"enocitabine, mitomycin.c, azodicarbonamide, anisomycin, nelarabine, artemisinin, floxuridine, altretamine, CB.10.277, cyclocytidine, cisplatin",0.593459819566045,0.25649023527157,FALSE +"H1299","Pearson.est","dopamine receptor antagonist",0.23102,0.646,0.905,145,0.934,"lurasidone, oxiperomide, remoxipride, clebopride",0.0433514207947967,0.0296531237699066,FALSE +"H1299","Pearson.est","estrogen receptor agonist",-0.24099,-0.579,0.93,690,0.974,"estrone, estradiol.cypionate, estradiol, ethinyl.estradiol, PPT",0.0315170514460649,0.0114410431213845,FALSE +"H1299","Pearson.est","estrogen receptor antagonist",0.38195,1.05,0.392,87,0.633,"clomifene, raloxifene",0.406713932979543,0.198596289982645,FALSE +"H1299","Pearson.est","FGFR inhibitor",-0.67164,-1.62,0.0232,1177,0.215,"nintedanib, MK.2461, regorafenib, lenvatinib, dovitinib, erdafitinib",1.6345120151091,0.667561540084395,TRUE +"H1299","Pearson.est","FLT3 inhibitor",-0.46666,-1.13,0.303,866,0.602,"midostaurin, TG.101348, lestaurtinib, KW.2449, sunitinib, ponatinib, sorafenib, tyrphostin.AG.1296, dovitinib, tozasertib, gilteritinib",0.518557371497695,0.220403508742175,FALSE +"H1299","Pearson.est","glucocorticoid receptor agonist",0.26801,0.766,0.763,183,0.862,"hydrocortisone, triamcinolone.acetonide, betamethasone, ciclesonide, fludroxycortide",0.11747546204512,0.0644927341752872,FALSE +"H1299","Pearson.est","glutamate receptor antagonist",0.3749,1.07,0.335,328,0.644,"latrepirdine, kynurenic.acid, IEM1754, JNJ.16259685, diazooxonorleucine, MTPG, CGP.37849",0.474955192963155,0.191114132640188,FALSE +"H1299","Pearson.est","glycogen synthase kinase inhibitor",0.27692,0.751,0.803,103,0.842,"LY2090314, indirubin",0.095284454721319,0.0746879085003505,FALSE +"H1299","Pearson.est","growth factor receptor inhibitor",-0.43285,-1.05,0.408,1310,0.675,"PHA.848125, danusertib",0.38933983691012,0.170696227168975,FALSE +"H1299","Pearson.est","HCV inhibitor",-0.50682,-1.21,0.229,1268,0.531,"Ro.9187, mericitabine",0.640164517660112,0.274905478918531,FALSE +"H1299","Pearson.est","HDAC inhibitor",0.31797,0.922,0.558,275,0.724,"JNJ.26481585, M.344, R306465, SB.939, PCI.24781, mocetinostat, vorinostat, scriptaid, panobinostat, tacedinaline",0.253365801062421,0.140261433802853,FALSE +"H1299","Pearson.est","histamine receptor antagonist",-0.36718,-0.876,0.647,1075,0.895,"cimetidine, pheniramine, ICI.162846, tiotidine, BF2.649, lafutidine",0.1890957193313,0.048176964684088,FALSE +"H1299","Pearson.est","HMGCR inhibitor",-0.92619,-2.22,0,1413,0,"fluvastatin, pitavastatin, atorvastatin, mevastatin",Inf,Inf,TRUE +"H1299","Pearson.est","HSP inhibitor",-0.60298,-1.45,0.0795,1339,0.304,"ganetespib, PU.H71, SNX.2112, NVP.AUY922, NMS.E973",1.09963287134353,0.517126416391246,FALSE +"H1299","Pearson.est","JAK inhibitor",-0.32679,-0.782,0.746,812,0.951,"TG.101209, AT.9283, AZD1480, TG.101348, PRT062070, lestaurtinib, ruxolitinib, WHI.P154, baricitinib, AZ960, tozasertib",0.127261172527331,0.0218194830625861,FALSE +"H1299","Pearson.est","KIT inhibitor",-0.62171,-1.49,0.0644,1122,0.328,"cediranib, sorafenib, KI.8751, regorafenib, OSI.930, lenvatinib, telatinib, motesanib, pazopanib",1.19111413264019,0.484126156288321,FALSE +"H1299","Pearson.est","MDM inhibitor",0.55404,1.52,0.0877,15,0.187,"RITA",1.05700040663396,0.728158393463501,FALSE +"H1299","Pearson.est","MEK inhibitor",0.60757,1.66,0.0494,264,0.14,"trametinib, AS.703026, selumetinib, cobimetinib, AZD8330, TAK.733, MEK1.2.inhibitor, PD.0325901, PD.318088, PD.198306, refametinib",1.30627305107635,0.853871964321762,TRUE +"H1299","Pearson.est","MET inhibitor",-0.58922,-1.42,0.0758,1258,0.338,"PHA.665752, LY2801653",1.12033079436795,0.471083299722345,FALSE +"H1299","Pearson.est","microtubule inhibitor",-0.66218,-1.6,0.0201,1130,0.217,"secnidazole, triclabendazole, podophyllotoxin, D.64131, cabazitaxel, vinflunine, vinblastine",1.69680394257951,0.66354026615147,TRUE +"H1299","Pearson.est","mTOR inhibitor",-0.24537,-0.582,0.929,586,1,"temsirolimus, everolimus, AZD8055, PF.05212384, PI.103, PP242, PF.04691502, SB.2343, AZD2014, sirolimus, XL388, OSI.027, torin.1, PKI.179, WAY.600, NVP.BEZ235, MLN0128, ku.0063794, LY3023414, deforolimus",0.0319842860063582,0,FALSE +"H1299","Pearson.est","NFkB pathway inhibitor",-0.42866,-1.03,0.432,888,0.68,"bindarit, IKK.2.inhibitor.V, BAY.11.7082, BAY.11.7085, EVP4593, betulinic.acid, parthenolide, bortezomib",0.364516253185088,0.167491087293764,FALSE +"H1299","Pearson.est","opioid receptor agonist",-0.34234,-0.83,0.708,914,0.895,"trimebutine, salvinorin.a, spiradoline",0.149966742310231,0.048176964684088,FALSE +"H1299","Pearson.est","p38 MAPK inhibitor",0.58603,1.63,0.0378,355,0.14,"SB.239063, TAK.715, talmapimod, skepinone.l, VX.702, SB.242235",1.42250820016277,0.853871964321762,TRUE +"H1299","Pearson.est","PARP inhibitor",-0.48475,-1.18,0.237,1119,0.554,"olaparib, AZD2461, AG.14361, talazoparib",0.625251653989896,0.25649023527157,FALSE +"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.61028,-1.45,0.0701,1079,0.304,"axitinib, SU014813, ponatinib, sorafenib, KI.8751, nintedanib, regorafenib, lenvatinib, telatinib, motesanib, crenolanib, dovitinib, pazopanib, CP.673451",1.15428198203334,0.517126416391246,FALSE +"H1299","Pearson.est","phosphatase inhibitor",-0.49167,-1.17,0.265,1031,0.557,"AS.1949490, BVT.948, menadione, bis.maltolato.oxovanadium.IV., GSK2830371",0.576754126063192,0.254144804826271,FALSE +"H1299","Pearson.est","phosphodiesterase inhibitor",-0.25295,-0.606,0.927,1050,1,"zardaverine, YM.976, GSK256066",0.0329202658555029,0,FALSE +"H1299","Pearson.est","PI3K inhibitor",0.22272,0.64,0.913,84,0.897,"taselisib, alpelisib, LY303511, CH5132799",0.039529222465701,0.0472075569559079,FALSE +"H1299","Pearson.est","PLK inhibitor",-0.80575,-1.98,0.00131,1222,0.0241,"NMS.1286937, GSK461364, GW.843682X, BI.2536, volasertib, rigosertib",2.88272870434424,1.61798295742513,TRUE +"H1299","Pearson.est","potassium channel blocker",-0.62462,-1.49,0.0546,1036,0.328,"ML133, mepivacaine, ibutilide, dofetilide",1.26280735729526,0.484126156288321,FALSE +"H1299","Pearson.est","PPAR receptor agonist",0.41649,1.15,0.284,79,0.553,"pterostilbene, S26948",0.546681659952962,0.257274868695302,FALSE +"H1299","Pearson.est","progesterone receptor agonist",-0.28417,-0.688,0.851,924,1,"norgestrel, nomegestrol.acetate, tanaproget, norethindrone",0.0700704399154121,0,FALSE +"H1299","Pearson.est","proteasome inhibitor",-0.54181,-1.29,0.174,784,0.408,"ixazomib.citrate, oprozomib, delanzomib, ixazomib, bortezomib, carfilzomib, MG.132",0.7594507517174,0.38933983691012,FALSE +"H1299","Pearson.est","protein synthesis inhibitor",-0.56551,-1.36,0.12,1148,0.386,"puromycin, emetine, thiostrepton, tedizolid.phosphate, anguidine, cycloheximide, homoharringtonine, harringtonine, mercaptopurine",0.920818753952375,0.413412695328245,FALSE +"H1299","Pearson.est","protein tyrosine kinase inhibitor",0.61708,1.72,0.0285,39,0.129,"BMS.599626, CP.724714, AV.412",1.54515513999149,0.889410289700751,TRUE +"H1299","Pearson.est","RAF inhibitor",-0.57021,-1.39,0.113,876,0.349,"LGX818, dabrafenib, PLX.4720, vemurafenib, SB.590885, sorafenib, regorafenib, TAK.632, RAF265",0.94692155651658,0.45717457304082,FALSE +"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.44006,-1.04,0.432,1001,0.678,"sunitinib, cabozantinib, sorafenib, regorafenib",0.364516253185088,0.168770306132937,FALSE +"H1299","Pearson.est","retinoid receptor agonist",-0.45906,-1.12,0.323,1227,0.586,"adapalene, LE.135, fenretinide",0.490797477668897,0.232102383981909,FALSE +"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.61119,-1.47,0.0852,1226,0.313,"cladribine, triapine, fludarabine.phosphate, gemcitabine, clofarabine",1.0695604052333,0.504455662453552,FALSE +"H1299","Pearson.est","serotonin receptor agonist",-0.71659,-1.74,0.00651,1241,0.115,"SR.57227A, pardoprunox, aripiprazole",2.18641901143181,0.939302159646388,TRUE +"H1299","Pearson.est","serotonin receptor antagonist",-0.46235,-1.11,0.331,1110,0.589,"RS.16566, pirenperone, lerisetron, aripiprazole",0.480172006224281,0.229884705212898,FALSE +"H1299","Pearson.est","sodium channel blocker",-0.54434,-1.3,0.149,1025,0.408,"oxcarbazepine, brivaracetam, mepivacaine, quinidine, butamben, cibenzoline",0.826813731587726,0.38933983691012,FALSE +"H1299","Pearson.est","src inhibitor",0.52773,1.49,0.0813,25,0.189,"saracatinib, ZM.306416",1.08990945440593,0.723538195826756,FALSE +"H1299","Pearson.est","sterol demethylase inhibitor",-0.55249,-1.31,0.16,1323,0.407,"chlormidazole, posaconazole",0.795880017344075,0.39040559077478,FALSE +"H1299","Pearson.est","TGF beta receptor inhibitor",0.66757,1.89,0.0084,296,0.0833,"SB.431542, D.4476, repsox, LY2109761",2.07572071393812,1.07935499859321,TRUE +"H1299","Pearson.est","thymidylate synthase inhibitor",-0.4528,-1.1,0.347,1127,0.592,"trifluridine, doxifluridine",0.459670525209126,0.22767829327708,FALSE +"H1299","Pearson.est","topoisomerase inhibitor",-0.78856,-1.91,0.00263,1293,0.0412,"irinotecan, amsacrine, mitoxantrone, rubitecan, nemorubicin, voreloxin, idarubicin, daunorubicin, dexrazoxane, valrubicin, SN.38, etoposide, TAS.103, doxorubicin, epirubicin, etoposide.phosphate, teniposide, topotecan",2.58004425151024,1.38510278396687,TRUE +"H1299","Pearson.est","tubulin polymerization inhibitor",-0.64247,-1.53,0.0549,1183,0.31,"combretastatin.A.4, dolastatin.10, fosbretabulin, mebendazole, podophyllotoxin, CYT.997, KX2.391, epothilone.d, docetaxel, vincristine, paclitaxel, verubulin, vinorelbine, taltobulin, vindesine, vinblastine, BNC105",1.26042765554991,0.508638306165727,FALSE +"H1299","Pearson.est","tyrosine kinase inhibitor",0.3266,0.906,0.544,46,0.709,"BMS.599626, CP.724714, AV.412, vandetanib",0.26440110030182,0.149353764816933,FALSE +"H1299","Pearson.est","VEGFR inhibitor",-0.34936,-0.831,0.684,1122,0.913,"cediranib, SU014813, sorafenib, KI.8751, nintedanib, MK.2461, regorafenib, OSI.930, lenvatinib, telatinib, motesanib, foretinib, dovitinib, SAR131675, RAF265, pazopanib",0.164943898279884,0.039529222465701,FALSE +"H1299","Pearson.est","vitamin D receptor agonist",0.87641,2.43,0,131,0.00555,"maxacalcitol, paricalcitol, tacalcitol, alfacalcidol, ercalcitriol",Inf,2.25570701687732,TRUE +"H1703","Pearson.est","EGFR inhibitor",0.86993,2.3,0,49,0.0206,"canertinib, pelitinib, afatinib, dacomitinib, osimertinib, AZD8931, poziotinib, lapatinib, erlotinib, neratinib, ARRY.334543, BMS.690514, BMS.599626, XL.647, PD.168393, vandetanib, gefitinib, BIBU.1361, tucatinib, icotinib, AST.1306, TAK.285, rociletinib, PD.153035, CUDC.101, WZ.4002, WZ8040, CP.724714",Inf,1.68613277963085,TRUE +"H1703","Pearson.est","Abl kinase inhibitor",0.41252,1.12,0.325,137,0.808,"ZM.306416, dasatinib, bosutinib",0.488116639021126,0.0925886392254138,FALSE +"H1703","Pearson.est","acetylcholine receptor agonist",-0.28447,-0.68,0.878,607,0.966,"tremorine, xanomeline, oxiracetam, nefiracetam, nicotine",0.0565054840938974,0.0150228735845067,FALSE +"H1703","Pearson.est","acetylcholine receptor antagonist",-0.528,-1.27,0.192,1176,0.535,"iododexetimide, diphemanil, methscopolamine",0.71669877129645,0.271646217978772,FALSE +"H1703","Pearson.est","adenosine receptor antagonist",0.40176,1.07,0.354,88,0.856,"CGS.15943, MRS.1220",0.450996737974212,0.0675262353228468,FALSE +"H1703","Pearson.est","adrenergic receptor agonist",0.27559,0.745,0.761,125,0.921,"epinephrine, methyldopa, isoxsuprine",0.118615343229427,0.0357403698031511,FALSE +"H1703","Pearson.est","adrenergic receptor antagonist",-0.30058,-0.725,0.816,994,0.953,"naftidrofuryl, imiloxan, idazoxan, oxprenolol, vincamine, metoprolol, carvedilol",0.0883098412461389,0.0209070993616736,FALSE +"H1703","Pearson.est","AKT inhibitor",0.60526,1.62,0.0644,235,0.263,"triciribine, uprosertib, AZD5363, palomid.529",1.19111413264019,0.580044251510242,FALSE +"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.46874,1.26,0.199,286,0.638,"NVP.TAE684, brigatinib, GW.788388, CEP.37440, AP26113, AZD3463, SB.505124",0.701146923590293,0.195179321278838,FALSE +"H1703","Pearson.est","androgen receptor antagonist",-0.50436,-1.2,0.252,996,0.581,"RU.58841, flutamide, nilutamide",0.598599459218456,0.235823867609669,FALSE +"H1703","Pearson.est","antioxidant",-0.27257,-0.653,0.879,602,0.975,"rutin, benfotiamine, chlorogenic.acid, trolox, taurine",0.0560111249262281,0.0109953843014632,FALSE +"H1703","Pearson.est","AP inhibitor",-0.50977,-1.2,0.249,758,0.581,"embelin, birinapant, LCL.161, GDC.0152, idronoxil",0.603800652904264,0.235823867609669,FALSE +"H1703","Pearson.est","ATPase inhibitor",-0.62319,-1.48,0.0569,1095,0.5,"blebbistatin...., k.strophanthidin, ouabain, evodiamine, NMS.873, digitoxigenin, oligomycin.a, digoxin",1.24488773360493,0.301029995663981,FALSE +"H1703","Pearson.est","Aurora kinase inhibitor",-0.53733,-1.3,0.161,1126,0.557,"MK.8745, PHA.680632, TAK.901, AT.9283, danusertib, AMG900, CCT137690, barasertib.HQPA, SNS.314, barasertib, MK.5108",0.79317412396815,0.254144804826271,FALSE +"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.45412,-1.1,0.333,1027,0.573,"josamycin, tilmicosin, radezolid, valnemulin",0.47755576649368,0.24184537803261,FALSE +"H1703","Pearson.est","bacterial DNA gyrase inhibitor",-0.38991,-0.924,0.572,894,0.783,"lomefloxacin, norfloxacin, sparfloxacin, nadifloxacin",0.242603971206976,0.106238237942057,FALSE +"H1703","Pearson.est","BCL inhibitor",0.32225,0.888,0.588,23,0.972,"navitoclax",0.230622673923862,0.0123337350737254,FALSE +"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.28265,0.756,0.72,137,0.944,"dasatinib, bosutinib",0.142667503568732,0.025028005701931,FALSE +"H1703","Pearson.est","benzodiazepine receptor agonist",-0.30909,-0.738,0.786,1039,0.957,"temazepam, nefiracetam, lorazepam, bentazepam, indiplon",0.104577453960592,0.0190880622231565,FALSE +"H1703","Pearson.est","bromodomain inhibitor",-0.57067,-1.38,0.101,971,0.551,"I.BET151, JQ1...., OTX015, bromosporine",0.995678626217357,0.258848401148215,FALSE +"H1703","Pearson.est","calcium channel blocker",-0.48247,-1.17,0.261,1112,0.596,"mibefradil, pranidipine, carboxyamidotriazole",0.583359492661719,0.224753740259764,FALSE +"H1703","Pearson.est","CC chemokine receptor antagonist",-0.40593,-0.981,0.49,983,0.715,"PF.04136309, UNBS.5162, MK.0812, SB.225002",0.309803919971486,0.145693958198919,FALSE +"H1703","Pearson.est","CDK inhibitor",-0.3806,-0.909,0.575,707,0.789,"BMS.265246, JNJ.7706621, kenpaullone, indisulam, arcyriaflavin.a, AT.7519, palbociclib, NU6027, PHA.848125, BMS.387032, dinaciclib, PHA.793887, abemaciclib, R547",0.24033215531037,0.10292299679058,FALSE +"H1703","Pearson.est","CHK inhibitor",0.46095,1.27,0.194,316,0.692,"LY2603618, CHIR.124, SCH.900776, LY2606368, AZD7762",0.712198270069774,0.159893905543242,FALSE +"H1703","Pearson.est","cyclooxygenase inhibitor",0.21178,0.574,0.943,128,1,"aspirin, ramifenazone, phenazone, FK.3311",0.0254883072626717,0,FALSE +"H1703","Pearson.est","cytochrome P450 inhibitor",-0.42948,-1.04,0.437,745,0.645,"eplerenone, PF.4981517, clotrimazole, metyrapone, cobicistat",0.359518563029578,0.190440285364732,FALSE +"H1703","Pearson.est","DNA alkylating agent",-0.54256,-1.32,0.148,1158,0.544,"mitomycin.c, temozolomide, TH.302, dianhydrogalactitol, carmustine, melphalan, carboplatin, cisplatin",0.829738284605043,0.26440110030182,FALSE +"H1703","Pearson.est","DNA inhibitor",-0.52598,-1.27,0.192,1054,0.535,"teroxirone, tirapazamine, oxaliplatin, sangivamycin, pibenzimol, carmustine, melphalan, carboplatin, valrubicin, chlorambucil",0.71669877129645,0.271646217978772,FALSE +"H1703","Pearson.est","DNA methyltransferase inhibitor",-0.36463,-0.873,0.62,1209,0.812,"RG108, disulfiram",0.207608310501746,0.0904439707588247,FALSE +"H1703","Pearson.est","DNA polymerase inhibitor",-0.51414,-1.24,0.21,888,0.545,"idoxuridine, trifluridine, foscarnet, menadione",0.677780705266081,0.263603497723358,FALSE +"H1703","Pearson.est","DNA synthesis inhibitor",-0.48735,-1.15,0.306,841,0.571,"nelarabine, anisomycin, artesunate, enocitabine, estramustine.phosphate, CB.10.277, azodicarbonamide, mitomycin.c, artemisinin, altretamine, cyclocytidine, cisplatin",0.51427857351842,0.243363891754152,FALSE +"H1703","Pearson.est","dopamine receptor antagonist",-0.4681,-1.15,0.283,939,0.571,"UH.232...., thioproperazine, sertindole, amisulpride, isofloxythepin, paliperidone, nemonapride, raclopride",0.54821356447571,0.243363891754152,FALSE +"H1703","Pearson.est","estrogen receptor agonist",0.33472,0.884,0.602,966,0.926,"ethinyl.estradiol, PPT, equol, levonorgestrel, estradiol, erteberel, estrone, estradiol.cypionate",0.220403508742175,0.0333890133180656,FALSE +"H1703","Pearson.est","estrogen receptor antagonist",0.25024,0.666,0.849,151,0.996,"clomifene, raloxifene",0.0710923097560473,0.00174066157630127,FALSE +"H1703","Pearson.est","FGFR inhibitor",-0.56275,-1.34,0.126,1230,0.527,"orantinib, dovitinib, nintedanib, erdafitinib",0.899629454882437,0.278189384787453,FALSE +"H1703","Pearson.est","FLT3 inhibitor",-0.32943,-0.799,0.734,1239,0.91,"dovitinib, TG.101348, GTP.14564",0.134303940083929,0.0409586076789064,FALSE +"H1703","Pearson.est","glucocorticoid receptor agonist",-0.28479,-0.681,0.862,793,0.986,"halobetasol.propionate, clobetasol.propionate, beclomethasone.dipropionate, desonide, prednisolone.hemisuccinate, rimexolone, deflazacort, piretanide, flumethasone.pivalate, triamcinolone, fluticasone.propionate, dexamethasone.acetate, halcinonide",0.0644927341752872,0.0061230850587888,FALSE +"H1703","Pearson.est","glutamate receptor antagonist",0.19528,0.55,0.974,292,1,"diazooxonorleucine, latrepirdine, IEM1754, SIB.1757, tiletamine",0.0114410431213845,0,FALSE +"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.37111,1.02,0.413,28,0.847,"LY2090314",0.384049948343599,0.0721165896692931,FALSE +"H1703","Pearson.est","growth factor receptor inhibitor",0.18979,0.531,0.972,272,1,"GSK1838705A, AZD3463, GSK1904529A",0.0123337350737254,0,FALSE +"H1703","Pearson.est","HCV inhibitor",-0.48989,-1.16,0.302,1200,0.595,"Ro.9187, mericitabine",0.519993057042849,0.22548303427145,FALSE +"H1703","Pearson.est","HDAC inhibitor",-0.2421,-0.593,0.939,717,1,"SB.939, belinostat, givinostat, romidepsin, scriptaid, pyroxamide, resminostat, chidamide, dacinostat, R306465, NSC.3852, entinostat, AR.42, nexturastat.a, ACY.1215, RGFP966",0.0273344077338891,0,FALSE +"H1703","Pearson.est","histamine receptor antagonist",0.27575,0.763,0.719,203,0.974,"ranitidine, zolantidine, terfenadine, levocetirizine, ebastine, famotidine",0.143271109617117,0.0114410431213845,FALSE +"H1703","Pearson.est","HMGCR inhibitor",-0.82678,-1.98,0,1258,0.0339,"fluvastatin, pitavastatin, mevastatin, atorvastatin",Inf,1.46980030179692,TRUE +"H1703","Pearson.est","HSP inhibitor",-0.32247,-0.772,0.746,1445,0.93,"NMS.E973",0.127261172527331,0.0315170514460649,FALSE +"H1703","Pearson.est","JAK inhibitor",0.18176,0.494,0.993,106,0.983,"atiprimod, CEP.33779",0.00305075150461883,0.00744648216786438,FALSE +"H1703","Pearson.est","KIT inhibitor",-0.2165,-0.52,0.977,812,0.988,"sorafenib, lenvatinib, regorafenib, KI.8751, motesanib, cediranib, pazopanib",0.0101054362812269,0.00524305541237188,FALSE +"H1703","Pearson.est","MDM inhibitor",-0.46936,-1.13,0.314,1157,0.535,"idasanutlin, nutlin.3, AMG.232",0.503070351926785,0.271646217978772,FALSE +"H1703","Pearson.est","MEK inhibitor",0.75632,2.06,0.00345,172,0.0797,"trametinib, AS.703026, Ro.4987655, AZD8330, PD.0325901, cobimetinib, TAK.733, selumetinib, refametinib, PD.184352, MEK162, PD.318088",2.46218090492673,1.09854167860389,TRUE +"H1703","Pearson.est","MET inhibitor",0.36875,1.05,0.406,64,0.837,"INC.280",0.391473966422806,0.07727454200674,FALSE +"H1703","Pearson.est","microtubule inhibitor",-0.47108,-1.13,0.298,890,0.535,"cytochalasin.b, estramustine.phosphate, D.64131, secnidazole, triclabendazole, vinflunine, vinblastine",0.525783735923745,0.271646217978772,FALSE +"H1703","Pearson.est","mTOR inhibitor",-0.22373,-0.549,0.965,897,0.993,"WAY.600, PP242, PF.04691502, PI.103, torin.1, deforolimus, XL388, OSI.027, ku.0063794",0.0154726866562074,0.00305075150461883,FALSE +"H1703","Pearson.est","NFkB pathway inhibitor",-0.62203,-1.49,0.0834,1048,0.55,"bindarit, IKK.2.inhibitor.V, parthenolide, betulinic.acid, EVP4593, tyloxapol, BAY.11.7082",1.07883394936226,0.259637310505756,FALSE +"H1703","Pearson.est","opioid receptor agonist",0.33079,0.889,0.545,971,1,"ADL5859, salvinorin.a, BW.180C, spiradoline, trimebutine, cebranopadol",0.263603497723358,0,FALSE +"H1703","Pearson.est","p38 MAPK inhibitor",0.3449,0.928,0.541,951,1,"TAK.715, SB.239063, SB.242235, CMPD.1, talmapimod, VX.702, skepinone.l",0.266802734893431,0,FALSE +"H1703","Pearson.est","PARP inhibitor",-0.46748,-1.13,0.316,706,0.535,"niraparib, olaparib, E7449, talazoparib, endo.IWR.1, AG.14361, AZD2461",0.500312917381596,0.271646217978772,FALSE +"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.36549,-0.874,0.638,812,0.83,"sorafenib, lenvatinib, regorafenib, linifanib, KI.8751, axitinib, CP.673451, motesanib, orantinib, dovitinib, SU014813, nintedanib, pazopanib",0.195179321278838,0.0809219076239261,FALSE +"H1703","Pearson.est","phosphatase inhibitor",-0.64821,-1.56,0.0406,1384,0.429,"menadione, bis.maltolato.oxovanadium.IV., GSK2830371",1.39147396642281,0.367542707815276,FALSE +"H1703","Pearson.est","phosphodiesterase inhibitor",-0.24739,-0.588,0.937,1399,0.989,"GSK256066",0.0282604091122217,0.0048037084028206,FALSE +"H1703","Pearson.est","PI3K inhibitor",-0.20314,-0.481,0.98,925,0.984,"PF.04691502, PI.103, CUDC.907, YM.201636, idelalisib, BGT226, buparlisib, ZSTK.474, AZD6482",0.00877392430750515,0.00700490156865849,FALSE +"H1703","Pearson.est","PLK inhibitor",-0.56264,-1.35,0.13,1107,0.543,"GSK461364, rigosertib, volasertib, GW.843682X",0.886056647693163,0.265200170411153,FALSE +"H1703","Pearson.est","potassium channel blocker",-0.45254,-1.07,0.388,777,0.61,"meglitinide, ML133, ibutilide, dofetilide, mepivacaine",0.411168274405793,0.214670164989233,FALSE +"H1703","Pearson.est","PPAR receptor agonist",-0.66131,-1.59,0.0315,1330,0.582,"GW.501516, clofibrate",1.5016894462104,0.235077015350112,FALSE +"H1703","Pearson.est","progesterone receptor agonist",-0.42051,-1,0.455,1324,0.7,"tanaproget, norethindrone",0.341988603342888,0.154901959985743,FALSE +"H1703","Pearson.est","proteasome inhibitor",-0.52828,-1.26,0.192,1429,0.528,"MG.132",0.71669877129645,0.277366077466188,FALSE +"H1703","Pearson.est","protein synthesis inhibitor",-0.47875,-1.18,0.281,1160,0.6,"homoharringtonine, methacycline, bruceantin, thiostrepton, anguidine, mercaptopurine, harringtonine",0.55129368009492,0.221848749616356,FALSE +"H1703","Pearson.est","protein tyrosine kinase inhibitor",0.662,1.76,0.0169,49,0.225,"BMS.599626, AV.412, CP.724714",1.77211329538633,0.647817481888638,TRUE +"H1703","Pearson.est","RAF inhibitor",-0.39021,-0.927,0.565,759,0.797,"dabrafenib, sorafenib, regorafenib, LGX818, SB.590885, PLX.4720, RAF265, TAK.632",0.247951552180562,0.0985416786038876,FALSE +"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.47445,1.33,0.157,19,0.65,"vandetanib",0.804100347590766,0.187086643357144,FALSE +"H1703","Pearson.est","retinoid receptor agonist",-0.5624,-1.38,0.114,1229,0.551,"bexarotene, LE.135, adapalene, fenretinide",0.943095148663527,0.258848401148215,FALSE +"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.66801,-1.59,0.0323,1026,0.582,"LY2334737, gemcitabine, hydroxyurea, fludarabine.phosphate, clofarabine, fludarabine, triapine, pentostatin, cladribine",1.4907974776689,0.235077015350112,FALSE +"H1703","Pearson.est","serotonin receptor agonist",-0.57141,-1.38,0.115,1447,0.551,"aripiprazole",0.939302159646388,0.258848401148215,FALSE +"H1703","Pearson.est","serotonin receptor antagonist",-0.63751,-1.57,0.0274,1260,0.503,"paliperidone, pirenperone, lerisetron, aripiprazole",1.56224943717961,0.298432014944073,FALSE +"H1703","Pearson.est","sodium channel blocker",-0.47412,-1.13,0.324,1194,0.535,"quinidine, mepivacaine, butamben, cibenzoline",0.489454989793388,0.271646217978772,FALSE +"H1703","Pearson.est","src inhibitor",0.60815,1.62,0.0601,137,0.263,"saracatinib, ZM.306416, dasatinib, bosutinib",1.22112552799726,0.580044251510242,FALSE +"H1703","Pearson.est","sterol demethylase inhibitor",-0.56512,-1.36,0.119,1307,0.558,"chlormidazole, posaconazole",0.924453038607469,0.253365801062421,FALSE +"H1703","Pearson.est","TGF beta receptor inhibitor",0.30253,0.861,0.592,295,0.876,"repsox, SB.431542, LY2109761, D.4476",0.22767829327708,0.0574958938319193,FALSE +"H1703","Pearson.est","thymidylate synthase inhibitor",0.31623,0.869,0.573,992,0.907,"capecitabine, carmofur, raltitrexed, doxifluridine, ftorafur, trifluridine",0.24184537803261,0.0423927129399047,FALSE +"H1703","Pearson.est","topoisomerase inhibitor",-0.58964,-1.44,0.0773,1079,0.552,"idarubicin, SN.38, amsacrine, mitoxantrone, nemorubicin, daunorubicin, topotecan, dexrazoxane, etoposide, TAS.103, voreloxin, etoposide.phosphate, teniposide, doxorubicin, valrubicin, epirubicin",1.11182050608168,0.258060922270801,FALSE +"H1703","Pearson.est","tubulin polymerization inhibitor",-0.53891,-1.29,0.183,1137,0.548,"epothilone.d, flubendazole, combretastatin.A.4, ABT.751, KX2.391, vinorelbine, vincristine, vindesine, BNC105, verubulin, vinblastine, taltobulin",0.737548910269571,0.261219441515631,FALSE +"H1703","Pearson.est","tyrosine kinase inhibitor",0.43488,1.18,0.275,49,0.739,"BMS.599626, vandetanib, AV.412, dasatinib, CP.724714",0.560667306169737,0.131355561605174,FALSE +"H1703","Pearson.est","VEGFR inhibitor",0.29093,0.784,0.688,77,0.978,"BMS.690514, XL.647, vandetanib, ZM.306416, golvatinib",0.162411561764489,0.00966114521239857,FALSE +"H1703","Pearson.est","vitamin D receptor agonist",0.76649,2.03,0.0076,270,0.0686,"maxacalcitol, paricalcitol, ercalcitriol, tacalcitol, calcitriol",2.11918640771921,1.16367588429325,TRUE +"H460","Pearson.est","EGFR inhibitor",-0.28934,-0.706,0.848,908,0.877,"OSI.420, dovitinib, CGP.52411, CP.724714, osimertinib, TAK.285, WZ.3146, pelitinib, ARRY.334543, neratinib, brigatinib, afatinib, tyrphostin.AG.1478, vandetanib, erlotinib, rociletinib, salvianolic.acid.B",0.0716041477432862,0.0570004066339595,FALSE +"H460","Pearson.est","Abl kinase inhibitor",-0.61097,-1.5,0.0623,1163,0.382,"tozasertib, flumatinib, KW.2449, bosutinib, metatinib, GZD824",1.20551195334083,0.417936637088291,FALSE +"H460","Pearson.est","acetylcholine receptor agonist",-0.48976,-1.2,0.265,1412,0.505,"xanomeline",0.576754126063192,0.296708621881339,FALSE +"H460","Pearson.est","acetylcholine receptor antagonist",0.58377,1.65,0.0541,111,0.237,"hyoscyamine, dicycloverine",1.26680273489343,0.625251653989896,FALSE +"H460","Pearson.est","adenosine receptor antagonist",0.46695,1.3,0.171,267,0.427,"theophylline, CGS.15943, MRS.1220",0.767003889607846,0.369572124974976,FALSE +"H460","Pearson.est","adrenergic receptor agonist",-0.29593,-0.735,0.779,1368,0.876,"buphenine, clenbuterol",0.108462542327436,0.0574958938319193,FALSE +"H460","Pearson.est","adrenergic receptor antagonist",0.24559,0.716,0.832,159,0.905,"prazosin, atenolol...., atenolol......, RS.17053, dihydroergocristine",0.0798766737092761,0.0433514207947967,FALSE +"H460","Pearson.est","AKT inhibitor",0.30594,0.873,0.622,273,0.862,"GSK2110183, AZD5363, AT7867, CCT128930, MK.2206",0.206209615309181,0.0644927341752872,FALSE +"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41935,-1.04,0.408,868,0.694,"AZD3463, AP26113, alectinib, brigatinib, GW.788388, lorlatinib, crizotinib",0.38933983691012,0.158640529545145,FALSE +"H460","Pearson.est","androgen receptor antagonist",0.5527,1.58,0.0508,651,0.202,"RU.58841, bicalutamide, enzalutamide, cyproterone.acetate, flutamide, nilutamide",1.29413628771608,0.694648630553376,FALSE +"H460","Pearson.est","antioxidant",-0.5591,-1.37,0.13,933,0.378,"mesna, benfotiamine, chlorogenic.acid, rutin, taurine",0.886056647693163,0.422508200162775,FALSE +"H460","Pearson.est","AP inhibitor",0.23648,0.679,0.849,1107,0.882,"LCL.161, GDC.0152, birinapant, tanshinone.i, embelin, idronoxil",0.0710923097560473,0.0545314148681803,FALSE +"H460","Pearson.est","ATPase inhibitor",-0.51948,-1.28,0.169,1181,0.436,"rabeprazole, digitoxin, digoxin, thonzonium, digitoxigenin, k.strophanthidin",0.772113295386326,0.360513510731414,FALSE +"H460","Pearson.est","Aurora kinase inhibitor",-0.55904,-1.38,0.12,972,0.382,"PF.03814735, CYC116, AT.9283, AMG900, TAK.901, PHA.680632, GSK1070916, ENMD.2076, tozasertib, barasertib, KW.2449, alisertib, MK.5108, danusertib, MLN.8054, MK.8745, hesperadin",0.920818753952375,0.417936637088291,FALSE +"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.33301,-0.821,0.689,799,0.846,"azithromycin, radezolid, valnemulin, azalomycin.b, tedizolid",0.161780778092374,0.0726296369609765,FALSE +"H460","Pearson.est","bacterial DNA gyrase inhibitor",0.29638,0.821,0.694,287,0.842,"nadifloxacin, norfloxacin, trovafloxacin, sparfloxacin, sarafloxacin",0.158640529545145,0.0746879085003505,FALSE +"H460","Pearson.est","BCL inhibitor",0.35363,1.02,0.391,5,0.695,"ABT.737",0.407823242604133,0.158015195409886,FALSE +"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.59297,-1.46,0.0788,1163,0.33,"tozasertib, flumatinib, bosutinib, metatinib, GZD824",1.10347378251044,0.481486060122112,FALSE +"H460","Pearson.est","benzodiazepine receptor agonist",-0.25024,-0.613,0.917,1150,0.913,"ZK.93423, ivermectin, bentazepam",0.0376306643299789,0.039529222465701,FALSE +"H460","Pearson.est","bromodomain inhibitor",0.62603,1.79,0.0302,149,0.423,"I.BET151",1.51999305704285,0.373659632624958,FALSE +"H460","Pearson.est","calcium channel blocker",0.41089,1.12,0.29,240,0.696,"mibefradil, pranidipine, fendiline, efonidipine.monoethanolate",0.537602002101044,0.157390760389438,FALSE +"H460","Pearson.est","CC chemokine receptor antagonist",-0.33402,-0.816,0.709,1132,0.834,"navarixin, UNBS.5162",0.149353764816933,0.0788339493622613,FALSE +"H460","Pearson.est","CDK inhibitor",-0.34273,-0.84,0.657,1046,0.874,"alvocidib, indisulam, palbociclib, R547, PHA.793887, ribociclib, aminopurvalanol.a, JNJ.7706621, PHA.848125",0.182434630440219,0.058488567365597,FALSE +"H460","Pearson.est","CHK inhibitor",-0.42276,-1.05,0.402,659,0.695,"AZD7762, CHIR.124, SB.218078, PF.477736, SCH.900776, LY2606368",0.39577394691553,0.158015195409886,FALSE +"H460","Pearson.est","cyclooxygenase inhibitor",-0.24999,-0.619,0.912,1215,0.942,"suxibuzone, FK.3311, ketoprofen, AM.404",0.0400051616715838,0.0259490972071227,FALSE +"H460","Pearson.est","cytochrome P450 inhibitor",0.59268,1.77,0.0377,307,0.226,"itraconazole, eplerenone, metyrapone, morin, cobicistat",1.42365864979421,0.645891560852599,TRUE +"H460","Pearson.est","DNA alkylating agent",-0.4506,-1.1,0.328,1122,0.638,"cisplatin, dianhydrogalactitol, mitomycin.c, satraplatin, dacarbazine",0.484126156288321,0.195179321278838,FALSE +"H460","Pearson.est","DNA inhibitor",0.16308,0.468,0.988,130,0.991,"pibenzimol, metronidazole",0.00524305541237188,0.00392634551472468,FALSE +"H460","Pearson.est","DNA methyltransferase inhibitor",-0.31047,-0.757,0.753,1058,0.883,"decitabine, fdcyd, disulfiram",0.123205023799299,0.0540392964224314,FALSE +"H460","Pearson.est","DNA polymerase inhibitor",-0.25361,-0.616,0.91,1310,0.927,"cephalomannine",0.0409586076789064,0.0329202658555029,FALSE +"H460","Pearson.est","DNA synthesis inhibitor",-0.51639,-1.29,0.18,1004,0.438,"artemisinin, CB.10.277, enocitabine, cisplatin, cyclocytidine, mitomycin.c, anisomycin, floxuridine",0.744727494896694,0.3585258894959,FALSE +"H460","Pearson.est","dopamine receptor antagonist",0.62825,1.77,0.0121,211,0.226,"paliperidone, remoxipride, acetophenazine, domperidone, lurasidone, isofloxythepin, clebopride, raclopride, mesoridazine, nemonapride",1.91721462968355,0.645891560852599,TRUE +"H460","Pearson.est","estrogen receptor agonist",0.30944,0.855,0.603,206,0.856,"equol, erteberel",0.219682687859849,0.0675262353228468,FALSE +"H460","Pearson.est","estrogen receptor antagonist",0.54142,1.54,0.0431,123,0.212,"tamoxifen, clomifene",1.36552272983927,0.673664139071249,TRUE +"H460","Pearson.est","FGFR inhibitor",-0.37248,-0.912,0.55,699,0.831,"erdafitinib, lenvatinib, lucitanib, AZD4547, dovitinib, MK.2461, PD.173074, regorafenib",0.259637310505756,0.080398976215889,FALSE +"H460","Pearson.est","FLT3 inhibitor",-0.38983,-0.953,0.521,1093,0.799,"midostaurin, gilteritinib, ENMD.2076, quizartinib, tozasertib, KW.2449, lestaurtinib",0.283162276700476,0.0974532206860086,FALSE +"H460","Pearson.est","glucocorticoid receptor agonist",0.5849,1.62,0.0598,229,0.226,"hydrocortisone, piretanide, prednisolone.hemisuccinate, deflazacort, triamcinolone, triamcinolone.acetonide, dexamethasone.acetate, halcinonide, methylprednisolone",1.22329881601159,0.645891560852599,FALSE +"H460","Pearson.est","glutamate receptor antagonist",0.25087,0.687,0.815,1088,0.907,"MTPG, CPP, CGP.37849, IEM1754, kynurenic.acid, latrepirdine, JNJ.16259685, SIB.1757, diazooxonorleucine, LY456236, ACDPP, tiletamine, felbamate",0.0888423912600234,0.0423927129399047,FALSE +"H460","Pearson.est","glycogen synthase kinase inhibitor",0.37568,1.05,0.389,34,0.728,"CHIR.98014",0.410050398674292,0.137868620686963,FALSE +"H460","Pearson.est","growth factor receptor inhibitor",-0.61776,-1.52,0.0592,1358,0.439,"danusertib, PHA.848125, lestaurtinib",1.22767829327708,0.357535479757879,FALSE +"H460","Pearson.est","HCV inhibitor",0.36893,1.02,0.386,916,0.695,"Ro.9187, daclatasvir, PSI.7976, embelin, narlaprevir, mericitabine",0.413412695328245,0.158015195409886,FALSE +"H460","Pearson.est","HDAC inhibitor",-0.60371,-1.49,0.066,1095,0.304,"NSC.3852, entinostat, SB.939, givinostat, dacinostat, AR.42, PCI.24781, JNJ.26481585, M.344, vorinostat, tacedinaline, belinostat, resminostat, trichostatin.a, panobinostat, chidamide",1.18045606445813,0.517126416391246,FALSE +"H460","Pearson.est","histamine receptor antagonist",0.25468,0.733,0.778,1,0.918,"chloropyramine",0.109020403010311,0.0371573187987575,FALSE +"H460","Pearson.est","HMGCR inhibitor",-0.71271,-1.75,0.00535,1204,0.205,"mevastatin, atorvastatin, pitavastatin, fluvastatin",2.27164621797877,0.688246138944246,TRUE +"H460","Pearson.est","HSP inhibitor",-0.61184,-1.49,0.0671,1044,0.304,"ganetespib, NVP.AUY922, KW.2478, SNX.5422, BIIB021, VER.49009, SNX.2112, PU.H71, NMS.E973",1.17327747983101,0.517126416391246,FALSE +"H460","Pearson.est","JAK inhibitor",-0.49242,-1.21,0.253,1116,0.505,"LY2784544, tozasertib, TG.101209, ruxolitinib, CEP.33779, AZ960, lestaurtinib, WHI.P154",0.596879478824182,0.296708621881339,FALSE +"H460","Pearson.est","KIT inhibitor",-0.36153,-0.88,0.61,932,0.869,"dasatinib, sorafenib, OSI.930, midostaurin, pazopanib, masitinib, regorafenib, KI.8751",0.214670164989233,0.0609802235513335,FALSE +"H460","Pearson.est","MDM inhibitor",-0.28585,-0.706,0.829,1337,0.877,"serdemetan",0.0814454694497265,0.0570004066339595,FALSE +"H460","Pearson.est","MEK inhibitor",0.25845,0.759,0.761,354,0.913,"cobimetinib, PD.318088, selumetinib, AS.703026, BIX.02188, trametinib, PD.0325901, U.0126, AZD8330",0.118615343229427,0.039529222465701,FALSE +"H460","Pearson.est","MET inhibitor",-0.44703,-1.09,0.368,883,0.636,"AMG458, INC.280, LY2801653",0.434152181326482,0.196542884351586,FALSE +"H460","Pearson.est","microtubule inhibitor",-0.63341,-1.56,0.044,1341,0.403,"vinflunine, D.64131, vinblastine, cabazitaxel",1.35654732351381,0.39469495385889,FALSE +"H460","Pearson.est","mTOR inhibitor",-0.57367,-1.4,0.126,949,0.39,"PF.05212384, WYE.125132, torin.2, PF.04691502, GSK2126458, torin.1, LY3023414, everolimus, PI.103, MLN0128, AZD8055, NVP.BEZ235, voxtalisib, PP242, temsirolimus, WAY.600, AZD2014, PKI.179, deforolimus, sirolimus",0.899629454882437,0.408935392973501,FALSE +"H460","Pearson.est","NFkB pathway inhibitor",0.39266,1.1,0.307,239,0.681,"tyloxapol, betulinic.acid, curcumin, parthenolide....",0.512861624522813,0.166852888087215,FALSE +"H460","Pearson.est","opioid receptor agonist",-0.33272,-0.831,0.681,1010,0.848,"trimebutine, spiradoline, salvinorin.a",0.166852888087215,0.0716041477432862,FALSE +"H460","Pearson.est","p38 MAPK inhibitor",-0.34903,-0.865,0.626,774,0.852,"TAK.715, VX.702, SB.239063, talmapimod, SB.242235, CMPD.1",0.20342566678957,0.0695604052332999,FALSE +"H460","Pearson.est","PARP inhibitor",-0.56807,-1.38,0.117,1145,0.382,"niraparib, AG.14361, olaparib, talazoparib",0.931814138253838,0.417936637088291,FALSE +"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.3031,-0.746,0.777,1208,0.88,"crenolanib, pazopanib, masitinib, regorafenib, KI.8751",0.109578981199086,0.0555173278498314,FALSE +"H460","Pearson.est","phosphatase inhibitor",-0.39621,-0.973,0.517,1264,0.783,"sodium.stibogluconate, bis.maltolato.oxovanadium.IV.",0.286509456906058,0.106238237942057,FALSE +"H460","Pearson.est","phosphodiesterase inhibitor",-0.59326,-1.49,0.0679,969,0.304,"trequinsin, YM.976, anagrelide, EMD.53998, GSK256066, zardaverine, papaverine",1.1681302257195,0.517126416391246,FALSE +"H460","Pearson.est","PI3K inhibitor",-0.33872,-0.831,0.668,861,0.848,"PI.828, GDC.0980, LY303511, CH5132799, alpelisib, PF.05212384, PF.04691502, GSK2126458, TG.100713, LY3023414, GDC.0941, PI.103, NVP.BEZ235, voxtalisib, PKI.179, CUDC.907",0.175223537524454,0.0716041477432862,FALSE +"H460","Pearson.est","PLK inhibitor",-0.88802,-2.17,0,1425,0.00175,"BI.2536, rigosertib, volasertib, HMN.214, NMS.1286937",Inf,2.75696195131371,TRUE +"H460","Pearson.est","potassium channel blocker",-0.35791,-0.869,0.622,903,0.866,"ibutilide, meglitinide, oleoylethanolamide",0.206209615309181,0.0624821079826534,FALSE +"H460","Pearson.est","PPAR receptor agonist",0.56622,1.59,0.0735,113,0.22,"fenofibrate, GW.501516, S26948",1.1337126609158,0.657577319177794,FALSE +"H460","Pearson.est","progesterone receptor agonist",0.35094,0.988,0.446,943,0.716,"melengestrol.acetate, norethindrone.acetate, danazol, levonorgestrel, dienogest, norgestrel, norethindrone, tanaproget, nomegestrol.acetate",0.350665141287858,0.145086977692144,FALSE +"H460","Pearson.est","proteasome inhibitor",0.33056,0.925,0.537,972,0.799,"oprozomib, carfilzomib, MG.132, ONX.0914, ixazomib.citrate, ixazomib, bortezomib, delanzomib",0.270025714300444,0.0974532206860086,FALSE +"H460","Pearson.est","protein synthesis inhibitor",-0.72718,-1.79,0.0116,1210,0.218,"tedizolid.phosphate, mercaptopurine, bruceantin, harringtonine, puromycin, thiostrepton, emetine, anguidine, homoharringtonine, cycloheximide",1.93554201077308,0.661543506395395,TRUE +"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.54713,-1.31,0.142,963,0.466,"CP.724714, mubritinib, AV.412, PP.121, NVP.TAE226, tyrphostin.A9",0.847711655616944,0.33161408331,FALSE +"H460","Pearson.est","RAF inhibitor",-0.38598,-0.938,0.561,921,0.805,"CEP.32496, sorafenib, LGX818, regorafenib, RAF265",0.251037138743839,0.0942041196321315,FALSE +"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.60142,-1.5,0.0597,964,0.382,"sorafenib, apatinib, cabozantinib, vandetanib, regorafenib",1.22402566887063,0.417936637088291,FALSE +"H460","Pearson.est","retinoid receptor agonist",-0.47069,-1.16,0.3,1162,0.542,"adapalene, adarotene",0.522878745280338,0.266000713461613,FALSE +"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.48552,-1.21,0.223,886,0.505,"hydroxyurea, fludarabine, gemcitabine, clofarabine, triapine, fludarabine.phosphate",0.651695136951839,0.296708621881339,FALSE +"H460","Pearson.est","serotonin receptor agonist",-0.53627,-1.29,0.167,1447,0.438,"aripiprazole",0.777283528852417,0.3585258894959,FALSE +"H460","Pearson.est","serotonin receptor antagonist",-0.50929,-1.25,0.203,1276,0.47,"SB.228357, SB.200646, SB.216641, aripiprazole",0.692503962086787,0.327902142064283,FALSE +"H460","Pearson.est","sodium channel blocker",0.29858,0.835,0.649,173,0.853,"benzethonium, lappaconite, mepivacaine",0.187755303199631,0.069050968832477,FALSE +"H460","Pearson.est","src inhibitor",-0.57958,-1.42,0.0892,932,0.378,"dasatinib, saracatinib, KX2.391, masitinib, bosutinib, TG.100572",1.04963514562388,0.422508200162775,FALSE +"H460","Pearson.est","sterol demethylase inhibitor",-0.4141,-1.01,0.443,1169,0.733,"ketoconazole, chlormidazole, lanoconazole",0.35359627377693,0.134896025358872,FALSE +"H460","Pearson.est","TGF beta receptor inhibitor",0.59553,1.66,0.041,393,0.274,"adaprev, repsox, SB.431542, LY2109761, SB.525334",1.38721614328026,0.562249437179612,FALSE +"H460","Pearson.est","thymidylate synthase inhibitor",-0.48419,-1.19,0.255,939,0.506,"raltitrexed, trifluridine, carmofur",0.593459819566045,0.295849483160201,FALSE +"H460","Pearson.est","topoisomerase inhibitor",-0.6876,-1.67,0.0215,1097,0.232,"nemorubicin, exatecan.mesylate, valrubicin, etoposide.phosphate, doxorubicin, idarubicin, etoposide, voreloxin, rubitecan, camptothecin, genz.644282, teniposide, daunorubicin, dexrazoxane, irinotecan, SN.38, amonafide, amsacrine, TAS.103, topotecan, mitoxantrone",1.66756154008439,0.6345120151091,TRUE +"H460","Pearson.est","tubulin polymerization inhibitor",-0.69769,-1.69,0.0144,1168,0.253,"CYT.997, vincristine, combretastatin.A.4, dolastatin.10, taltobulin, fenbendazole, indibulin, plinabulin, vinorelbine, epothilone.b, epothilone.d, docetaxel, verubulin, paclitaxel, vindesine, ABT.751, vinblastine, parbendazole, BNC105, fosbretabulin, mebendazole",1.84163750790475,0.596879478824182,FALSE +"H460","Pearson.est","tyrosine kinase inhibitor",-0.52616,-1.29,0.174,932,0.438,"dasatinib, CP.724714, sorafenib, mubritinib, apatinib, AMG.208, AV.412, UNC2250, cabozantinib, PP.121, vandetanib, NVP.TAE226, regorafenib, aminopurvalanol.a, tyrphostin.A9, tivantinib",0.7594507517174,0.3585258894959,FALSE +"H460","Pearson.est","VEGFR inhibitor",-0.32047,-0.782,0.732,877,0.866,"axitinib, dovitinib, SAR131675, MK.2461, sorafenib, foretinib, OSI.930, tivozanib, PD.173074, cabozantinib, ENMD.2076, pazopanib, vandetanib, regorafenib, KI.8751, TG.100572, RAF265",0.135488918941608,0.0624821079826534,FALSE +"H460","Pearson.est","vitamin D receptor agonist",0.73212,2.08,0.0119,157,0.206,"paricalcitol, alfacalcidol, tacalcitol, doxercalciferol, maxacalcitol",1.92445303860747,0.686132779630847,TRUE +"H520","Pearson.est","EGFR inhibitor",-0.3734,-0.906,0.572,840,0.735,"XL.647, GW.583340, brigatinib, dacomitinib, gefitinib, CGP.52411, lapatinib, poziotinib, AZD8931, afatinib, tyrphostin.AG.1478, WZ.4002, BMS.599626, AEE788, CP.724714, rociletinib, CNX.2006, ARRY.334543, tucatinib, WZ.3146, BIBX.1382, TAK.285, neratinib, dovitinib, CUDC.101",0.242603971206976,0.133712660915805,FALSE +"H520","Pearson.est","Abl kinase inhibitor",-0.33234,-0.799,0.705,727,0.805,"bafetinib, flumatinib, nilotinib, ponatinib, KW.2449, bosutinib, tozasertib, metatinib, imatinib, GZD824",0.151810883008601,0.0942041196321315,FALSE +"H520","Pearson.est","acetylcholine receptor agonist",0.32596,0.881,0.558,122,0.798,"nefiracetam, nicotine",0.253365801062421,0.0979971086492706,FALSE +"H520","Pearson.est","acetylcholine receptor antagonist",0.85162,2.25,0,85,0.0244,"dicycloverine, hyoscyamine, iododexetimide",Inf,1.61261017366127,TRUE +"H520","Pearson.est","adenosine receptor antagonist",-0.34437,-0.835,0.665,910,0.789,"sulmazole, SCH.58261, MRS.1220, CGS.15943",0.177178354696895,0.10292299679058,FALSE +"H520","Pearson.est","adrenergic receptor agonist",0.33357,0.923,0.559,970,0.829,"midodrine, isoetharine, isoxsuprine, norepinephrine, terbutaline, ritodrine, xylazine, buphenine, epinephrine, oxymetazoline, A61603, clenbuterol, metaraminol, methyldopa, lidamidine",0.252588192113577,0.0814454694497265,FALSE +"H520","Pearson.est","adrenergic receptor antagonist",0.19685,0.556,0.959,276,1,"atenolol...., imiloxan, metoprolol, levobunolol, RS.17053",0.0181813928293364,0,FALSE +"H520","Pearson.est","AKT inhibitor",-0.4742,-1.13,0.322,1249,0.452,"ONC201, A.674563, GDC.0068, uprosertib",0.492144128304169,0.344861565188618,FALSE +"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.31646,-0.757,0.756,968,0.828,"NVP.TAE684, CEP.37440, alectinib, crizotinib, AZD3463",0.121478204498793,0.0819696632151199,FALSE +"H520","Pearson.est","androgen receptor antagonist",0.77514,2.13,0,236,0.0334,"bicalutamide, RU.58841, cyproterone.acetate",Inf,1.47625353318844,TRUE +"H520","Pearson.est","antioxidant",0.40014,1.05,0.347,871,0.732,"benfotiamine, trolox, taurine, chlorogenic.acid, mesna, rutin",0.459670525209126,0.135488918941608,FALSE +"H520","Pearson.est","AP inhibitor",0.3158,0.9,0.543,156,0.835,"LCL.161, GDC.0152",0.265200170411153,0.0783135245163979,FALSE +"H520","Pearson.est","ATPase inhibitor",-0.60996,-1.44,0.0715,1153,0.337,"digitoxigenin, oligomycin.a, evodiamine, rabeprazole, NMS.873, digoxin, k.strophanthidin",1.14569395819892,0.472370099128661,FALSE +"H520","Pearson.est","Aurora kinase inhibitor",-0.64433,-1.58,0.0504,967,0.308,"CCT129202, PF.03814735, MK.5108, tozasertib, aurora.a.inhibitor.i, hesperadin, AT.9283, MK.8745, GSK1070916, CYC116, SNS.314, alisertib, AMG900, barasertib.HQPA, CCT137690, ENMD.2076, barasertib, TAK.901, danusertib, PHA.680632",1.29756946355447,0.511449283499556,FALSE +"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.45588,-1.09,0.357,1047,0.494,"azalomycin.b, radezolid, valnemulin, tedizolid",0.447331783887807,0.306273051076353,FALSE +"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.43329,1.2,0.221,398,0.586,"sparfloxacin, sarafloxacin, norfloxacin, novobiocin, trovafloxacin, nadifloxacin",0.655607726314889,0.232102383981909,FALSE +"H520","Pearson.est","BCL inhibitor",0.28681,0.774,0.741,1035,0.892,"ABT.737, obatoclax, venetoclax, HA14.1, navitoclax, oridonin, gossypol, TW.37",0.130181792020672,0.0496351456238769,FALSE +"H520","Pearson.est","Bcr.Abl kinase inhibitor",-0.33735,-0.807,0.711,727,0.812,"bafetinib, flumatinib, nilotinib, ponatinib, bosutinib, tozasertib, metatinib, imatinib, GZD824",0.148130399270234,0.0904439707588247,FALSE +"H520","Pearson.est","benzodiazepine receptor agonist",0.3781,1.05,0.35,157,0.732,"lorazepam, nefiracetam, gamma.aminobutyric.acid, indiplon",0.455931955649724,0.135488918941608,FALSE +"H520","Pearson.est","bromodomain inhibitor",-0.73355,-1.76,0.0188,1309,0.152,"JQ1...., I.BET.762, I.BET151, OTX015",1.72584215073632,0.818156412055227,TRUE +"H520","Pearson.est","calcium channel blocker",-0.36026,-0.881,0.626,1128,0.756,"carboxyamidotriazole, tetrandrine, penfluridol",0.20342566678957,0.121478204498793,FALSE +"H520","Pearson.est","CC chemokine receptor antagonist",-0.60963,-1.46,0.0862,1108,0.327,"RS.504393, ZK811752, SB.225002, UNBS.5162",1.06449273417529,0.485452247339714,FALSE +"H520","Pearson.est","CDK inhibitor",-0.54595,-1.3,0.18,1169,0.385,"JNJ.7706621, BMS.265246, dinaciclib, TG.02, AT.7519, PHA.793887, arcyriaflavin.a, ribociclib, aminopurvalanol.a, BMS.387032, indisulam",0.744727494896694,0.414539270491499,FALSE +"H520","Pearson.est","CHK inhibitor",0.3817,1.03,0.414,290,0.73,"LY2606368, AZD7762, SCH.900776, LY2603618",0.382999658879101,0.136677139879544,FALSE +"H520","Pearson.est","cyclooxygenase inhibitor",-0.15721,-0.375,1,810,0.999,"curcumin, FK.3311, ramifenazone, FR.122047, ketoprofen, meloxicam, tepoxalin, suxibuzone, amfenac, piroxicam, AM.404",0,0.000434511774017692,FALSE +"H520","Pearson.est","cytochrome P450 inhibitor",0.80005,2.22,0,247,0.0244,"eplerenone, morin, metyrapone, clotrimazole, itraconazole, cobicistat",Inf,1.61261017366127,TRUE +"H520","Pearson.est","DNA alkylating agent",-0.47069,-1.16,0.304,1120,0.447,"cyclophosphamide, estramustine, dacarbazine, satraplatin, mitomycin.c",0.517126416391246,0.349692476868064,FALSE +"H520","Pearson.est","DNA inhibitor",0.15828,0.428,0.986,978,0.996,"carboplatin, nithiamide, sangivamycin, metronidazole, nimorazole, carmustine, tirapazamine, melphalan, busulfan, bendamustine, pibenzimol, chlorambucil, mechlorethamine, primaquine, teroxirone, oxaliplatin",0.0061230850587888,0.00174066157630127,FALSE +"H520","Pearson.est","DNA methyltransferase inhibitor",-0.54092,-1.3,0.168,1092,0.385,"azacitidine, SGI.1027, disulfiram, decitabine, fdcyd",0.774690718274137,0.414539270491499,FALSE +"H520","Pearson.est","DNA polymerase inhibitor",-0.49607,-1.22,0.247,927,0.446,"famciclovir, cidofovir, adefovir.dipivoxil, idoxuridine, trifluridine, cephalomannine",0.607303046740334,0.350665141287858,FALSE +"H520","Pearson.est","DNA synthesis inhibitor",-0.3802,-0.937,0.54,1230,0.702,"floxuridine, enocitabine, anisomycin, mitomycin.c",0.267606240177031,0.153662887870195,FALSE +"H520","Pearson.est","dopamine receptor antagonist",0.51328,1.42,0.108,309,0.421,"acetophenazine, isofloxythepin, paliperidone, ziprasidone, UH.232...., raclopride, remoxipride, clebopride",0.96657624451305,0.375717904164332,FALSE +"H520","Pearson.est","estrogen receptor agonist",0.35694,1.01,0.41,934,0.73,"equol, estrone, PPT, estradiol, estradiol.cypionate, levonorgestrel, erteberel, ethinyl.estradiol",0.387216143280265,0.136677139879544,FALSE +"H520","Pearson.est","estrogen receptor antagonist",0.25728,0.711,0.807,1077,0.961,"tamoxifen, clomifene, raloxifene, toremifene, danazol, fulvestrant",0.0931264652779296,0.0172766123314547,FALSE +"H520","Pearson.est","FGFR inhibitor",-0.59586,-1.43,0.11,1027,0.331,"erdafitinib, PD.173074, nintedanib, dovitinib, lenvatinib, regorafenib",0.958607314841775,0.480172006224281,FALSE +"H520","Pearson.est","FLT3 inhibitor",-0.59935,-1.46,0.0793,1164,0.327,"tyrphostin.AG.1296, TG.02, lestaurtinib, pacritinib, dovitinib, TG.101348, ENMD.2076, sorafenib",1.1007268126824,0.485452247339714,FALSE +"H520","Pearson.est","glucocorticoid receptor agonist",0.60788,1.64,0.0712,373,0.293,"hydrocortisone, piretanide, dexamethasone.acetate, prednisolone.acetate, fluocinolone.acetonide, prednisolone.hemisuccinate, flumethasone.pivalate, triamcinolone, clobetasol.propionate, halobetasol.propionate, flumethasone, prednisolone, beclomethasone.dipropionate, desonide",1.14752000636314,0.533132379645891,FALSE +"H520","Pearson.est","glutamate receptor antagonist",0.38509,1.05,0.354,113,0.732,"JNJ.16259685, latrepirdine, kynurenic.acid",0.450996737974212,0.135488918941608,FALSE +"H520","Pearson.est","glycogen synthase kinase inhibitor",0.50278,1.4,0.136,228,0.369,"CHIR.98014, CHIR.99021, LY2090314, tideglusib",0.866461091629782,0.43297363384094,FALSE +"H520","Pearson.est","growth factor receptor inhibitor",-0.59028,-1.42,0.1,1283,0.325,"AZD3463, lestaurtinib, danusertib",1,0.488116639021126,FALSE +"H520","Pearson.est","HCV inhibitor",-0.36561,-0.868,0.628,1275,0.759,"mericitabine, narlaprevir",0.202040356262804,0.11975822410452,FALSE +"H520","Pearson.est","HDAC inhibitor",-0.63293,-1.52,0.0484,1198,0.281,"entinostat, scriptaid, NSC.3852, AR.42, R306465, resminostat, vorinostat, dacinostat, trichostatin.a, givinostat, chidamide, SB.939, PCI.24781, M.344",1.31515463835559,0.55129368009492,FALSE +"H520","Pearson.est","histamine receptor antagonist",0.51537,1.41,0.126,357,0.392,"chloropyramine, cimetidine, famotidine, nizatidine, terfenadine, BF2.649, zolantidine, astemizole, lafutidine, ICI.162846",0.899629454882437,0.406713932979543,FALSE +"H520","Pearson.est","HMGCR inhibitor",0.69819,1.97,0.0109,375,0.0796,"simvastatin, pitavastatin, atorvastatin, fluvastatin, mevastatin",1.96257350205938,1.09908693226233,TRUE +"H520","Pearson.est","HSP inhibitor",-0.51165,-1.22,0.238,887,0.446,"XL888, NVP.AUY922, KW.2478, SNX.2112, VER.49009, BIIB021, PU.H71, NMS.E973",0.623423042943488,0.350665141287858,FALSE +"H520","Pearson.est","JAK inhibitor",-0.55235,-1.34,0.146,978,0.379,"ruxolitinib, tozasertib, LY2784544, WHI.P154, AT.9283, TG.101209, TG.02, baricitinib, lestaurtinib, pacritinib, TG.101348, AZ960",0.835647144215563,0.421360790031928,FALSE +"H520","Pearson.est","KIT inhibitor",-0.57923,-1.4,0.114,1269,0.339,"imatinib, pazopanib, lenvatinib, OSI.930, regorafenib, sorafenib",0.943095148663527,0.469800301796918,FALSE +"H520","Pearson.est","MDM inhibitor",0.30444,0.819,0.662,1009,0.882,"idasanutlin, nutlin.3, AMG.232, CGM097, RITA, serdemetan",0.1791420105603,0.0545314148681803,FALSE +"H520","Pearson.est","MEK inhibitor",0.19404,0.519,0.968,268,1,"nobiletin, PD.184352, cobimetinib, MEK1.2.inhibitor",0.0141246426916063,0,FALSE +"H520","Pearson.est","MET inhibitor",-0.47057,-1.13,0.316,1173,0.452,"AMG458, NVP.BVU972, INC.280",0.500312917381596,0.344861565188618,FALSE +"H520","Pearson.est","microtubule inhibitor",-0.48566,-1.18,0.274,1094,0.433,"triclabendazole, vinblastine, cabazitaxel, D.64131, vinflunine",0.562249437179612,0.363512103646635,FALSE +"H520","Pearson.est","mTOR inhibitor",-0.56926,-1.37,0.112,1095,0.368,"XL388, NVP.BEZ235, WAY.600, everolimus, voxtalisib, PI.103, WYE.125132, PF.05212384, AZD8055, PF.04691502, AZD2014, torin.2, PP242, deforolimus, sirolimus, GSK2126458, PKI.179",0.950781977329818,0.434152181326482,FALSE +"H520","Pearson.est","NFkB pathway inhibitor",-0.32545,-0.791,0.725,999,0.799,"BAY.11.7082, Ro.106.9920, parthenolide...., EVP4593",0.139661993429006,0.0974532206860086,FALSE +"H520","Pearson.est","opioid receptor agonist",0.53234,1.45,0.116,99,0.428,"cebranopadol, BW.180C",0.935542010773082,0.368556230986828,FALSE +"H520","Pearson.est","p38 MAPK inhibitor",-0.5281,-1.26,0.21,833,0.415,"VX.702, SB.239063, SB.242235, TAK.715, talmapimod",0.677780705266081,0.381951903287907,FALSE +"H520","Pearson.est","PARP inhibitor",-0.67364,-1.62,0.0391,1303,0.282,"olaparib, PJ.34, talazoparib, niraparib",1.40782324260413,0.549750891680639,FALSE +"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.48347,-1.18,0.288,1189,0.433,"nintedanib, crenolanib, imatinib, pazopanib, axitinib, dovitinib, lenvatinib, regorafenib, sorafenib",0.540607512240769,0.363512103646635,FALSE +"H520","Pearson.est","phosphatase inhibitor",-0.26084,-0.623,0.901,812,0.92,"CID.5458317, sodium.stibogluconate, bis.maltolato.oxovanadium.IV., alexidine, mycophenolate.mofetil",0.045275209020937,0.0362121726544447,FALSE +"H520","Pearson.est","phosphodiesterase inhibitor",0.22462,0.605,0.916,1125,1,"YM.976, trequinsin, GSK256066, anagrelide, cilostamide, zardaverine, EMD.53998, enoximone, papaverine, avanafil",0.0381045263321496,0,FALSE +"H520","Pearson.est","PI3K inhibitor",-0.57436,-1.36,0.126,1058,0.366,"buparlisib, idelalisib, NVP.BEZ235, BGT226, voxtalisib, GDC.0941, PI3K.IN.2, PI.103, PIK.75, PF.05212384, PF.04691502, alpelisib, CH5132799, taselisib, GSK2126458, PKI.179, CUDC.907",0.899629454882437,0.436518914605589,FALSE +"H520","Pearson.est","PLK inhibitor",-0.80291,-1.95,0.00141,1157,0.0773,"GSK461364, GW.843682X, HMN.214, rigosertib, volasertib, BI.2536, NMS.1286937",2.85078088734462,1.11182050608168,TRUE +"H520","Pearson.est","potassium channel blocker",0.47712,1.3,0.186,760,0.467,"meglitinide, mepivacaine, oleoylethanolamide, ibutilide, ML133, dofetilide",0.730487055782084,0.330683119433888,FALSE +"H520","Pearson.est","PPAR receptor agonist",0.595,1.61,0.0482,139,0.282,"fenofibrate, S26948",1.31695296176115,0.549750891680639,FALSE +"H520","Pearson.est","progesterone receptor agonist",0.31828,0.888,0.577,990,0.821,"norethindrone.acetate, melengestrol.acetate, norgestrel, levonorgestrel, norethindrone, dienogest, danazol, nomegestrol.acetate, tanaproget",0.238824186844269,0.0856568428805592,FALSE +"H520","Pearson.est","proteasome inhibitor",0.34834,0.96,0.446,274,0.792,"ixazomib, ixazomib.citrate, oprozomib",0.350665141287858,0.101274818410506,FALSE +"H520","Pearson.est","protein synthesis inhibitor",-0.72971,-1.78,0.013,1383,0.17,"harringtonine, thiostrepton, cycloheximide, emetine, tedizolid.phosphate, bruceantin, homoharringtonine, anguidine",1.88605664769316,0.769551078621726,TRUE +"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.64324,-1.55,0.0564,952,0.287,"AV.412, PP.121, BMS.599626, CP.724714, NVP.TAE226, mubritinib, tyrphostin.A9",1.24872089601666,0.542118103266008,FALSE +"H520","Pearson.est","RAF inhibitor",-0.47551,-1.13,0.332,1172,0.452,"RAF265, CEP.32496, regorafenib, sorafenib",0.478861916295964,0.344861565188618,FALSE +"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.77201,-1.88,0,1416,0.0918,"regorafenib, sorafenib",Inf,1.03715731879876,TRUE +"H520","Pearson.est","retinoid receptor agonist",-0.64411,-1.54,0.0603,1197,0.273,"bexarotene, fenretinide, adapalene, adarotene",1.21968268785985,0.563837352959244,FALSE +"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.29074,-0.694,0.821,936,0.886,"clofarabine, pentostatin, LY2334737, fludarabine.phosphate",0.0856568428805592,0.0525662781129492,FALSE +"H520","Pearson.est","serotonin receptor agonist",-0.49282,-1.2,0.236,1447,0.446,"aripiprazole",0.627087997029893,0.350665141287858,FALSE +"H520","Pearson.est","serotonin receptor antagonist",-0.55159,-1.32,0.169,1411,0.39,"SB.200646, aripiprazole",0.772113295386326,0.408935392973501,FALSE +"H520","Pearson.est","sodium channel blocker",0.16028,0.437,1,1218,1,"oxcarbazepine, mepivacaine, benzethonium, lappaconite, quinidine, butamben, mexiletine, ajmaline, triamterene, A.803467, cibenzoline, benzocaine, brivaracetam",0,0,FALSE +"H520","Pearson.est","src inhibitor",0.29531,0.804,0.701,105,0.873,"dasatinib, PP.2",0.154281982033341,0.0589857562944303,FALSE +"H520","Pearson.est","sterol demethylase inhibitor",-0.51159,-1.21,0.233,1101,0.446,"ketoconazole, posaconazole, chlormidazole",0.632644078973981,0.350665141287858,FALSE +"H520","Pearson.est","TGF beta receptor inhibitor",0.71859,1.95,0.00339,408,0.0732,"LY2109761, SB.431542, adaprev, SB.525334, repsox",2.46980030179692,1.13548891894161,TRUE +"H520","Pearson.est","thymidylate synthase inhibitor",-0.44037,-1.07,0.378,819,0.51,"ftorafur, raltitrexed, trifluridine, doxifluridine, carmofur",0.422508200162775,0.292429823902064,FALSE +"H520","Pearson.est","topoisomerase inhibitor",-0.64769,-1.56,0.0668,1148,0.304,"exatecan.mesylate, irinotecan, nemorubicin, epirubicin, dexrazoxane, valrubicin, etoposide, SN.38, etoposide.phosphate, daunorubicin, TAS.103, voreloxin, mitoxantrone, teniposide, amonafide, amsacrine, idarubicin, doxorubicin",1.17522353752445,0.517126416391246,FALSE +"H520","Pearson.est","tubulin polymerization inhibitor",-0.71085,-1.72,0.0127,1069,0.171,"verubulin, CYT.997, vinblastine, dolastatin.10, flubendazole, BNC105, vincristine, plinabulin, combretastatin.A.4, nocodazole, ABT.751, docetaxel, taltobulin, paclitaxel, parbendazole, vindesine, indibulin, KX2.391, fenbendazole, albendazole, vinorelbine, fosbretabulin, mebendazole",1.89619627904404,0.767003889607846,TRUE +"H520","Pearson.est","tyrosine kinase inhibitor",-0.52838,-1.27,0.213,1052,0.417,"PP.121, UNC2250, BMS.599626, CP.724714, tyrphostin.AG.99, NVP.TAE226, mubritinib, aminopurvalanol.a, tyrphostin.A9, regorafenib, tivantinib, sorafenib",0.671620396561262,0.379863945026242,FALSE +"H520","Pearson.est","VEGFR inhibitor",-0.48641,-1.18,0.286,1028,0.433,"linifanib, KI.8751, PD.173074, AEE788, RAF265, golvatinib, nintedanib, foretinib, tivozanib, pazopanib, axitinib, dovitinib, lenvatinib, OSI.930, ENMD.2076, regorafenib, sorafenib",0.543633966870957,0.363512103646635,FALSE +"H520","Pearson.est","vitamin D receptor agonist",-0.28259,-0.682,0.837,1090,0.881,"calcitriol, maxacalcitol",0.07727454200674,0.0550240915879521,FALSE diff --git a/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_venn_diagram.pdf 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+
+
+ + + + diff --git a/Examples/cell_corr/Fig5 - Coldren prot/GSEA/GSEA_mean_results.csv b/Examples/cell_corr/Fig5 - Coldren prot/GSEA/GSEA_mean_results.csv new file mode 100644 index 0000000..2889312 --- /dev/null +++ b/Examples/cell_corr/Fig5 - Coldren prot/GSEA/GSEA_mean_results.csv @@ -0,0 +1,182 @@ +"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.672466666666667,1.25558175854102,0.000500902490448373,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.00237269600738703 +"KEGG_O_GLYCAN_BIOSYNTHESIS",0.597333333333333,1.72334585976842,6.29964077415202e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1650, H2126, H3255, H1299, H1703",5.66967669673682e-05 +"KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.5966,1.16305378821691,0.131233783810938,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1650",0.241041643734376 +"KEGG_SPLICEOSOME",0.545733333333333,1.11641789837387,0.0584208765996686,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.127674486094202 +"KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.524466666666667,1.51136810618094,4.6745523473771e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1650, H2009, H1703",5.25887139079924e-05 +"KEGG_ETHER_LIPID_METABOLISM",0.506933333333333,1.35497277076841,0.00048229690721715,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H2009",0.0023463092783537 +"KEGG_SPHINGOLIPID_METABOLISM",0.500466666666667,1.19246586454088,0.0149998744158875,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H460",0.040908748406966 +"KEGG_VIRAL_MYOCARDITIS",0.4722,1.13090154933386,0.0615437159070151,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.131879391229318 +"KEGG_MISMATCH_REPAIR",0.443066666666667,1.30684912598786,0.00598004614674568,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, H2009, H358",0.0188843562528811 +"KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.4406,1.12519228832866,0.0971748312056591,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1650",0.197930497114806 +"KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.440133333333333,1.75886009622575,5.49128974491639e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,6,"HCC95, H2009, HCC15, H1299, H460, H520",1.00243076619302e-05 +"KEGG_CELL_ADHESION_MOLECULES_CAMS",0.431933333333333,1.3744170954921,0.00052659565934736,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H2009, H1299, H460",0.00243044150468012 +"KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.419333333333333,1.12305505949916,0.100780850160188,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.201561700320376 +"KEGG_ABC_TRANSPORTERS",0.417666666666667,1.43609782131335,0.000127881591164287,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H2126, H358, HCC15, H460",0.000852543941095244 +"KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.3892,0.924497485123675,0.736958168918568,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.861379677956768 +"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.3855,1.68689486015898,3.93671322667305e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,6,"H1650, H2009, H2126, H358, A549, HCC15",1.59025956229216e-06 +"KEGG_HOMOLOGOUS_RECOMBINATION",0.3756,1.16966166048136,0.0588721241434374,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.127674486094202 +"KEGG_PROTEASOME",0.3662,0.977887314571572,0.614913616422301,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.768642020527876 +"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.365866666666667,1.25963043711052,0.0189674660830448,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, HCC15",0.0474186652076121 +"KEGG_SELENOAMINO_ACID_METABOLISM",0.352533333333333,1.14550162852454,0.114279589238038,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.218833255987732 +"KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.3522,1.25217098330403,0.0124285162566258,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0360827891321395 +"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.348538461538461,1.51866633461647,0.000156293697932313,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, HCC44, H1703, H460, H520",13,3,"H2009, H2126, H460",0.00100474520099344 +"KEGG_CARDIAC_MUSCLE_CONTRACTION",0.337866666666667,1.11619653074093,0.177021253496053,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.300602128578203 +"KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.337,1.24563334435597,0.0220053125676506,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H520",0.0535264359753664 +"KEGG_OTHER_GLYCAN_DEGRADATION",0.3186,1.38038766811563,0.00134148542210353,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H3255",0.00536594168841411 +"KEGG_CITRATE_CYCLE_TCA_CYCLE",0.313133333333333,1.01014057484708,0.491903279318528,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.651260540392598 +"KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.3126,1.42674458621216,0.000417573693523436,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, A549",0.00214752185240624 +"KEGG_DILATED_CARDIOMYOPATHY",0.290533333333333,1.42279874425959,0.00034186055014046,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.00180984997133185 +"KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.285666666666667,1.35629751617444,0.0315973762789953,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.0748358911870942 +"KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.279090909090909,1.75446547156366,7.43455023563206e-07,"HCC827, HCC95, H1650, H1975, H2009, H3255, H358, H1299, H1703, H460, H520",11,2,"H358, H1299",1.11518253534481e-05 +"KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.2766,1.0493978409409,0.459467442308323,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.621835636206753 +"KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.271933333333333,1.16884390175364,0.097865634684543,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.197930497114806 +"KEGG_PYRIMIDINE_METABOLISM",0.269,0.774216654801115,0.999358715563287,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_ARACHIDONIC_ACID_METABOLISM",0.262,1.53702960283789,5.69533906513128e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1299, H1703",5.66967669673682e-05 +"KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.258466666666667,1.09405483452722,0.290135685402503,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC15",0.435203528103754 +"KEGG_PROTEIN_EXPORT",0.234066666666667,1.05876420325549,0.521478530048017,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2126, H520",0.680189387019153 +"KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.233466666666667,1.16404349861449,0.119553500985217,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.226522422919359 +"KEGG_FATTY_ACID_METABOLISM",0.231533333333333,1.16745118384739,0.151131438689147,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.264113193825694 +"KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.226466666666667,1.18532695107822,0.0866870294138956,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.179352474649439 +"KEGG_PARKINSONS_DISEASE",0.225,0.946624378666488,0.821673374053166,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.930196272513018 +"KEGG_HUNTINGTONS_DISEASE",0.2226,0.765188286819469,0.998242457247393,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_RNA_DEGRADATION",0.221466666666667,0.864226067205853,0.972753012668788,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.2105,1.66062057677243,0.00103759332982502,"H1975, H2009, H2126, H3255, A549, H1703",6,2,"H2009, H2126",0.00424469998564782 +"KEGG_DNA_REPLICATION",0.206266666666667,1.35642126129578,0.0036669292793307,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0132009454055905 +"KEGG_RIBOSOME",0.204133333333333,1.43509088147589,0.00066677007542013,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.00300046533939058 +"KEGG_RIBOFLAVIN_METABOLISM",0.200666666666667,1.5668825585796,3.74679243414228e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, H2126, H3255",4.74193122806455e-05 +"KEGG_BASAL_TRANSCRIPTION_FACTORS",0.193533333333333,1.15056233870143,0.197774990012114,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.326600900937437 +"KEGG_ADHERENS_JUNCTION",0.174666666666667,1.01930765485112,0.674131699242546,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.82525522817797 +"KEGG_TRYPTOPHAN_METABOLISM",0.170866666666667,1.3582344036425,0.00426190723965305,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H358, H1299, H520",0.0148072325025254 +"KEGG_TASTE_TRANSDUCTION",0.162333333333333,1.43649288530219,0.000720358012438812,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, H1650, H1299, H460",0.00308724862473777 +"KEGG_N_GLYCAN_BIOSYNTHESIS",0.157533333333333,1.09824443458423,0.328691478142679,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.473315728525458 +"KEGG_TIGHT_JUNCTION",0.147666666666667,1.11873459553108,0.272206621331278,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.419639614643691 +"KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.142466666666667,1.42883158393076,0.0106360318796106,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.0319080956388317 +"KEGG_LYSOSOME",0.140533333333333,1.23712846466939,0.0538840101293896,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.119742244731977 +"KEGG_PURINE_METABOLISM",0.136466666666667,0.843261937501092,0.995864837135482,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_ARGININE_AND_PROLINE_METABOLISM",0.136066666666667,1.15453289668325,0.192112079070541,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.320186798450901 +"KEGG_FOCAL_ADHESION",0.134333333333333,1.13425354098548,0.251356571294139,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.400390998521638 +"KEGG_GLYCEROLIPID_METABOLISM",0.1306,1.14914538431206,0.215589479816782,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.349604561865053 +"KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.119,1.4198468227242,0.000699608559764023,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.00307145221359815 +"KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.112666666666667,1.54452015972907,0.00043946544653623,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H1703",0.00219732723268115 +"KEGG_CALCIUM_SIGNALING_PATHWAY",0.109666666666667,0.993170080864204,0.807599844192115,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.920050455408738 +"KEGG_ECM_RECEPTOR_INTERACTION",0.101333333333333,1.6218854401444,3.64022213759701e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H2009, H1703, H460",9.36057121096375e-06 +"KEGG_RNA_POLYMERASE",0.0995333333333333,1.32231760106838,0.0144541419844746,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.0400268547262374 +"KEGG_BASAL_CELL_CARCINOMA",0.0876666666666666,1.46760123363003,0.000223725390327427,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.00134235234196456 +"KEGG_OXIDATIVE_PHOSPHORYLATION",0.0764,0.960801064588443,0.857556532808406,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.962122526998545 +"KEGG_NOTCH_SIGNALING_PATHWAY",0.0738666666666667,1.11540158473892,0.298581848556822,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.441468672114004 +"KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.0522,1.71280464235042,7.26321988954105e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, H358, HCC15, H1299",1.11518253534481e-05 +"KEGG_PEROXISOME",0.0457333333333333,1.22158003460779,0.0861926660845922,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.179352474649439 +"KEGG_NON_HOMOLOGOUS_END_JOINING",0.0443333333333335,1.3346889775025,0.00539599643706583,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0173442742619973 +"KEGG_LONG_TERM_POTENTIATION",0.0418,0.921603974445795,0.952099382214413,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_LEISHMANIA_INFECTION",0.0296,1.30123023108354,0.012817604651115,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0366217275746144 +"KEGG_BETA_ALANINE_METABOLISM",0.0198666666666667,1.30399155708631,0.0155232995929428,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H1299",0.0417043869661149 +"KEGG_GNRH_SIGNALING_PATHWAY",-0.00126666666666664,0.936276322663856,0.945947703781824,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.0073333333333333,0.858830239891669,0.994088183674746,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.0124000000000001,1.3125574708506,0.0178351278296087,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H1299",0.0458617572761367 +"KEGG_PHENYLALANINE_METABOLISM",-0.0186000000000001,1.59528214253332,7.85987090755877e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, HCC15, H1299, H520",6.57876531627429e-05 +"KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.0221333333333333,1.29401285413502,0.0174018767922613,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2126, H1299",0.0453962003276383 +"KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.0311333333333334,1.17335732388894,0.138514842974093,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.249412963811021 +"KEGG_GAP_JUNCTION",-0.0363333333333333,0.994244269114319,0.807426641030979,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.920050455408738 +"KEGG_APOPTOSIS",-0.0479333333333333,0.951766813177822,0.894386966862529,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.987666589173345 +"KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.0579999999999999,1.70118530106847,4.41738767303379e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, HCC15, H1299, H520",1.59025956229216e-06 +"KEGG_LONG_TERM_DEPRESSION",-0.0587333333333334,0.914511771904758,0.972142412341298,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_BASE_EXCISION_REPAIR",-0.0721333333333333,1.12844398979091,0.302796209255759,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.443116403788916 +"KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.0748666666666666,0.890866581855368,0.985357875887122,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_LYSINE_DEGRADATION",-0.076,1.10629639531444,0.387677508380549,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.540945360530999 +"KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.0786,0.975603461599903,0.87001614080591,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.966684600895455 +"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.0826,1.14990507682777,0.273000829547311,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.419639614643691 +"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.0871333333333334,1.34746910203996,0.00720901437328106,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1703, H520",0.022372803227424 +"KEGG_PYRUVATE_METABOLISM",-0.0904666666666667,1.05404783482309,0.609448929852799,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC15",0.767138513101425 +"KEGG_SMALL_CELL_LUNG_CANCER",-0.0954000000000001,1.16362302437565,0.1544797215928,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.267368748910616 +"KEGG_ALZHEIMERS_DISEASE",-0.0971333333333334,0.84996528220415,0.992945589270559,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_PRIMARY_IMMUNODEFICIENCY",-0.105066666666667,1.47856699286199,0.000214481722820739,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0013312658657839 +"KEGG_HISTIDINE_METABOLISM",-0.110466666666667,1.38952987253483,0.00225233480124444,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1299, H520",0.00844625550466666 +"KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.1122,1.12677512016754,0.299217655543936,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.441468672114004 +"KEGG_OOCYTE_MEIOSIS",-0.124266666666667,1.00400515555497,0.694177112701672,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.838603223397993 +"KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.1264,1.42966928243663,0.000294050572850866,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.00160391221555018 +"KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.1266,1.39693796774026,0.000986005386901424,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H358",0.00412746441028503 +"KEGG_PANCREATIC_CANCER",-0.1344,0.94337174917572,0.91927466695173,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.135133333333333,1.06864633109012,0.49206351940774,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.651260540392598 +"KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.1354,1.24082339021888,0.0431903679961617,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0996700799911424 +"KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.136066666666667,1.17018212664688,0.12380227554322,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.232129266643537 +"KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.149133333333333,1.08176640379564,0.390807756038077,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.541118431437337 +"KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.171733333333333,1.22675905578576,0.0503123936759265,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.113202885770835 +"KEGG_GLUTATHIONE_METABOLISM",-0.172866666666667,1.33162322355981,0.00449320594102581,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H1299",0.0152599447053707 +"KEGG_ENDOCYTOSIS",-0.177933333333333,0.99941114567291,0.722849146881948,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.854041392805905 +"KEGG_MAPK_SIGNALING_PATHWAY",-0.1786,0.920283325938268,0.938647598914148,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_PATHWAYS_IN_CANCER",-0.180866666666667,0.914254721200878,0.953985812142981,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.189933333333333,1.03581965244001,0.557435029426145,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.721858311487094 +"KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.192133333333333,0.969695376811462,0.799982751977542,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.920050455408738 +"KEGG_OLFACTORY_TRANSDUCTION",-0.1978,1.18894972860204,0.112746934755932,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.218833255987732 +"KEGG_TYROSINE_METABOLISM",-0.202,1.51690097614464,4.05733068740359e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.000292127809493058 +"KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.2034,1.11598821038319,0.26031303266817,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.411020577897111 +"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.212066666666667,1.67432794477864,6.01024237406851e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1650, H2126, H1299, H1703, H520",5.66967669673682e-05 +"KEGG_RENAL_CELL_CARCINOMA",-0.2204,0.902843982725065,0.947458763274857,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.222866666666667,1.44972799747631,0.000245648202857858,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, HCC15",0.00138177114107545 +"KEGG_BLADDER_CANCER",-0.227666666666667,1.20031886636526,0.0687365930445618,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.145559844094366 +"KEGG_WNT_SIGNALING_PATHWAY",-0.234333333333333,0.882469883473705,0.973589770774693,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_PROPANOATE_METABOLISM",-0.239933333333333,1.24058761806462,0.0330158472644251,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H1299",0.0771799026960586 +"KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.239933333333333,1.12201607237449,0.237410048316255,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.381551863365409 +"KEGG_CELL_CYCLE",-0.2414,0.901784722488846,0.942204852693699,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_P53_SIGNALING_PATHWAY",-0.241466666666667,1.07226328501024,0.383286612107163,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.540945360530999 +"KEGG_ENDOMETRIAL_CANCER",-0.245733333333333,1.0943073782513,0.275097080710864,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.419639614643691 +"KEGG_RETINOL_METABOLISM",-0.247266666666667,1.45355006138501,0.000243037101879537,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.00138177114107545 +"KEGG_AXON_GUIDANCE",-0.253733333333333,1.13440711177165,0.183271886161668,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.308307845879442 +"KEGG_VIBRIO_CHOLERAE_INFECTION",-0.253866666666667,1.09722948938723,0.278079211768368,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.420624017800893 +"KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.26,1.87014132391875,1.10407926508619e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,7,"HCC95, H2126, H358, HCC44, H1299, H1703, H460",6.62447559051712e-07 +"KEGG_VEGF_SIGNALING_PATHWAY",-0.2644,1.15344742898347,0.146441959805773,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.258426987892541 +"KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.272,1.06757937142196,0.386926042887952,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.540945360530999 +"KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.276666666666667,1.57274857979211,3.95160935672046e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC15, H1299, H520",4.74193122806455e-05 +"KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.295933333333333,1.01091538904575,0.592292149000059,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.750792864929652 +"KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.299133333333333,1.28948460726794,0.00503906090386486,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H1299",0.0167968696795495 +"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.326333333333333,1.36110048262776,0.00199494835292233,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H358",0.00780631964186998 +"KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.3408,1.33415239009642,0.00261866809934526,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.00961959709963565 +"KEGG_MELANOGENESIS",-0.3648,1.02314341963522,0.463669447659153,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.622839556557072 +"KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.3684,1.60445299089752,2.57688292181552e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H358",7.73064876544657e-06 +"KEGG_BUTANOATE_METABOLISM",-0.368533333333333,1.25607380735521,0.0135588420451466,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0381342432519748 +"KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.373333333333333,1.22760042746971,0.0181010826865845,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0458900687828902 +"KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.3742,0.922040841983539,0.767565887597776,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.891366837210321 +"KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.374266666666667,1.12830368674564,0.113906497442392,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.218833255987732 +"KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.382266666666667,1.29509025977048,0.00517100200515832,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2126, H1299",0.016923279289609 +"KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.390666666666667,1.0743129809103,0.213427372510628,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.349244791381027 +"KEGG_INSULIN_SIGNALING_PATHWAY",-0.396266666666667,0.88325683586103,0.860565149148699,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.962122526998545 +"KEGG_THYROID_CANCER",-0.3978,1.25931036682781,0.0101030288735249,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0308227999531268 +"KEGG_SULFUR_METABOLISM",-0.4,2.04643028786151,1.19572476198374e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,7,"HCC95, H1650, H2126, H358, HCC15, HCC44, H1299",9.35784596335104e-05 +"KEGG_TYPE_II_DIABETES_MELLITUS",-0.403533333333333,1.23808491900462,0.0202899206961409,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0500299414425391 +"KEGG_MELANOMA",-0.416933333333333,1.0923707158984,0.138562757672789,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.249412963811021 +"KEGG_ERBB_SIGNALING_PATHWAY",-0.419733333333333,0.916319849543088,0.71030482518822,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.846720983668077 +"KEGG_MTOR_SIGNALING_PATHWAY",-0.429666666666667,1.10164770533355,0.113889082322761,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.218833255987732 +"KEGG_COLORECTAL_CANCER",-0.432266666666667,0.778052189460199,0.978980800784636,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287 +"KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.436333333333333,0.916668865798228,0.725935183885019,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.854041392805905 +"KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.4488,0.920264496140725,0.663299471668763,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.817766471920393 +"KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.450666666666667,0.922043976846059,0.708672773067062,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.846720983668077 +"KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.470066666666667,0.970082946870794,0.436500452392577,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.595227889626242 +"KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.489466666666667,1.21064804763321,0.0122229442037023,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0360677042076463 +"KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.49,1.95793258310903,9.27721093641987e-05,"H1975, H3255, H358, A549, H1299",5,2,"H1975, H1299",0.000642268449444452 +"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.507142857142857,1.77050809122661,5.69515359142858e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,5,"H2009, H2126, H1299, H1703, H520",5.66967669673682e-05 +"KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.517,0.977805852771544,0.33304824077881,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.475783201112586 +"KEGG_PROSTATE_CANCER",-0.525666666666667,0.909425145483725,0.583921056863997,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.750755644539424 +"KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.531733333333333,0.892335256237144,0.588682540518253,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.750792864929652 +"KEGG_ACUTE_MYELOID_LEUKEMIA",-0.533666666666667,0.900569951805654,0.625309408167842,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.776246161863528 +"KEGG_GLIOMA",-0.534466666666667,0.949296345922048,0.4364529919426,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.595227889626242 +"KEGG_GALACTOSE_METABOLISM",-0.537666666666667,1.03971704026121,0.161343318269021,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.276588545604036 +"KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.551066666666667,0.856866256163925,0.678543187612998,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.82525522817797 +"KEGG_PRION_DISEASES",-0.553266666666667,1.18850058396925,0.0158805767090788,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H460",0.0420368207005027 +"KEGG_REGULATION_OF_AUTOPHAGY",-0.57,1.22758875151947,0.00427764494517401,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, H358",0.0148072325025254 +"KEGG_PPAR_SIGNALING_PATHWAY",-0.573733333333333,1.12748275036958,0.0272427021859196,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.065382485246207 +"KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.585266666666667,0.993933129876788,0.145892608654356,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.258426987892541 +"KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.617933333333333,0.92948560787034,0.271447178008282,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.419639614643691 +"KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.6494,0.894009092315541,0.313361883556529,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.4548801535498 +"KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.657333333333333,1.01798418923076,0.0437791676616006,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0997500022669382 +"KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.671666666666667,0.821736807592541,0.497959745751588,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.654253680549531 +"KEGG_NITROGEN_METABOLISM",-0.678,1.37687638204327,2.46248764504406e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, H358, HCC44",0.000184686573378305 +"KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.712866666666667,0.931559818389617,0.126674459768679,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.235066007818167 +"KEGG_STEROID_BIOSYNTHESIS",-0.732666666666667,1.55873330746781,7.6032554449495e-09,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H2126, A549, HCC44, H1299, H1703",6.62447559051712e-07 +"KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.824857142857143,1.50804712521464,2.41916465052312e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,5,"H1975, H358, HCC15, HCC44, H1299",3.34961259303202e-05 +"KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.869166666666667,1.52003264518373,4.42753468165306e-07,"HCC827, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",12,3,"H1975, H358, H520",9.96195303371939e-06 +"KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.994466666666667,1.21069135306277,8.04071316433524e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",6.57876531627429e-05 +"KEGG_LINOLEIC_ACID_METABOLISM",-1.0025,1.61471101645671,0.00212062380868656,"H1975, H3255, H358, H1299",4,1,"H1299",0.00812153799071449 +"KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-1.0076,1.28774358583421,5.56905981218346e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H2126, A549, HCC44",1.00243076619302e-05 +"KEGG_FOLATE_BIOSYNTHESIS",-1.04933333333333,1.42717736742678,8.357376828612e-10,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,6,"HCC95, H1650, H358, A549, H1299, H1703",1.50432782915016e-07 +"KEGG_TYPE_I_DIABETES_MELLITUS",-1.75,NA,NA,"HCC15",1,0,"",NA diff --git a/Examples/cell_corr/Fig5 - Coldren prot/GSEA/GSEA_results.csv b/Examples/cell_corr/Fig5 - Coldren prot/GSEA/GSEA_results.csv new file mode 100644 index 0000000..e6d329f --- /dev/null +++ b/Examples/cell_corr/Fig5 - Coldren prot/GSEA/GSEA_results.csv @@ -0,0 +1,2659 @@ +"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"HCC827","Input","KEGG_ABC_TRANSPORTERS",0.54049,1.55,0.0721,1185,0.411,"ABCA12, ABCC3, ABCC2, ABCA3, ABCG2, ABCB7, ABCD3, TAP2",1.14206473528057,0.386158178123931,FALSE +"HCC827","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.39562,-1.17,0.299,5858,0.601,"RELA, BRAF, STAT5A, BAD, SOS1, CCND1, IKBKG, RPS6KB2, MAP2K1, MTOR, AKT1, CHUK, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, RPS6KB1, TCF7L1, AKT2, MAPK1, PIK3CB",0.52432881167557,0.22112552799726,FALSE +"HCC827","Input","KEGG_ADHERENS_JUNCTION",0.43356,1.24,0.202,1419,0.599,"EGFR, CDH1, CTNNB1, CTNND1, RAC2, TGFBR2, CTNNA1, CTNNA2, MET, LMO7, TJP1, PTPRF, PTPRJ, AFDN, RAC3, PARD3, SRC, NECTIN4",0.694648630553376,0.222573177610689,FALSE +"HCC827","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.38221,-1.13,0.251,5467,0.614,"STAT3, PTPN11, PRKAA1, PRKAG1, RELA, RXRG, ACACB, ADIPOR2, PRKCQ, IKBKG, ACSL1, MTOR, STK11, MAPK8, AKT1, NFKBIB, CHUK, AKT3, IKBKB, MAPK9, IRS2, AKT2, CPT1A",0.600326278518962,0.211831628858832,FALSE +"HCC827","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.30791,-0.904,0.51,6277,0.766,"ASS1, ADSL, ASL, CAD, PPAT, CPS1, NIT2, GLUD2",0.292429823902064,0.115771230367396,FALSE +"HCC827","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.26484,-0.797,0.686,7350,0.815,"MAPK3, IRS2, MAPK1, PIK3CB, ATP1B3",0.163675884293248,0.0888423912600234,FALSE +"HCC827","Input","KEGG_ALZHEIMERS_DISEASE",-0.24201,-0.743,0.786,6859,0.865,"NDUFS5, NDUFB3, NAE1, NDUFA6, ITPR2, NDUFA9, CASP3, NDUFB4, CAPN1, NDUFV3, MAPK3, NDUFS7, NDUFA2, IDE, GSK3B, NDUFB7, CASP9, MAPK1, ITPR1, ATP2A1, PSEN2, ATP2A3, MAPT, SNCA, MME, BID",0.104577453960592,0.0629838925351858,FALSE +"HCC827","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.3628,1.01,0.397,1945,0.728,"PARS2, MARS2, TARS2, AARS2, YARS2, WARS2, FARS2",0.401209493236885,0.137868620686963,FALSE +"HCC827","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.39724,-1.2,0.22,7420,0.612,"UAP1, GALK1, NPL, GNPDA2, HK3, PGM3, GCK, GNE",0.657577319177794,0.213248577854439,FALSE +"HCC827","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.59984,-1.74,0.0367,7111,0.312,"CASP3, ALS2, MAPK14, BCL2L1, BAX, SOD1, CASP9, NEFL, NEFM, PRPH, PRPH2, NEFH, BID",1.43533393574791,0.505845405981557,FALSE +"HCC827","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.48545,1.36,0.129,1185,0.51,"CTSS, B2M, IFI30, LGMN, TAPBP, CREB1, PSME2, TAP2",0.889410289700751,0.292429823902064,FALSE +"HCC827","Input","KEGG_APOPTOSIS",-0.27932,-0.84,0.6,5858,0.773,"RELA, ATM, PRKACB, BIRC2, BAD, RIPK1, APAF1, IKBKG, IRAK4, PRKAR2B, PRKAR1A, DFFB, AKT1, CHUK, CASP3, XIAP, CAPN1, TNFRSF10D, BCL2L1, AKT3, BAX, IKBKB, AKT2, CASP9, PIK3CB, BID",0.221848749616356,0.111820506081675,FALSE +"HCC827","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.62342,1.78,0.0311,1027,1,"PTGS2, PTGES, GGT7, EPHX2, ALOX5, GGT1, GPX6, GPX7, PLA2G12A",1.50723961097316,0,FALSE +"HCC827","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34364,0.975,0.454,796,0.788,"PRODH, PRODH2, OAT, GATM, AGMAT, ALDH1B1, LAP3",0.342944147142896,0.103473782510445,FALSE +"HCC827","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.60072,1.69,0.0556,545,0.439,"ITGB6, ITGA1, DSC2, ITGA3, ITGA2, ITGA5, DSG2, CTNNB1, ITGB1, CTNNA1, GJA1, CTNNA2, ITGAV",1.25492520841794,0.357535479757879,FALSE +"HCC827","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.52864,1.52,0.0668,786,0.375,"UGDH, ALDH1B1",1.17522353752445,0.425968732272281,FALSE +"HCC827","Input","KEGG_AXON_GUIDANCE",0.4022,1.15,0.275,1664,0.637,"EPHB2, SEMA4B, ITGB1, RAC2, NRP1, EPHA1, EFNA5, EFNB2, MET, CFL2, SEMA3A, CXCR4, EFNA1, PLXNB3, PLXNB2, RAC3, PLXNB1, GNAI1, GNAI3, ROBO1, SLIT1, SLIT3, GNAI2, KRAS, NRAS, NTN4",0.560667306169737,0.19586056766465,FALSE +"HCC827","Input","KEGG_BASAL_CELL_CARCINOMA",0.42377,1.2,0.242,338,0.638,"CTNNB1, TP53",0.616184634019569,0.195179321278838,FALSE +"HCC827","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.24193,-0.713,0.832,4917,0.885,"TAF6, GTF2A1, TAF6L, TAF1, GTF2F1, TAF10, GTF2H2, TAF12, GTF2H4, GTF2H1, GTF2F2, GTF2IRD1, TAF2, TBPL1",0.0798766737092761,0.0530567293021746,FALSE +"HCC827","Input","KEGG_BASE_EXCISION_REPAIR",-0.37347,-1.13,0.267,6755,0.614,"MUTYH, LIG3, NTHL1, PARP1, FEN1, HMGB1, MPG",0.573488738635425,0.211831628858832,FALSE +"HCC827","Input","KEGG_BETA_ALANINE_METABOLISM",-0.29755,-0.878,0.539,6702,0.785,"ALDH7A1, ALDH2, SRM, EHHADH",0.268411234813261,0.105130343254747,FALSE +"HCC827","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.2539,0.72,0.816,2400,0.975,"ACOX3, SCD5, PECR, ACAA1, FADS1, ELOVL6, ACOT2, HADHA, ACOX1",0.0883098412461389,0.0109953843014632,FALSE +"HCC827","Input","KEGG_BLADDER_CANCER",0.4753,1.35,0.135,338,0.503,"CDKN2A, EGFR, CDH1, CDK4, TP53",0.869666231504994,0.298432014944073,FALSE +"HCC827","Input","KEGG_BUTANOATE_METABOLISM",0.36724,1.04,0.37,786,0.695,"ACSM3, ACADS, HMGCL, BDH2, ALDH1B1",0.431798275933005,0.158015195409886,FALSE +"HCC827","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.286,-0.876,0.555,6577,0.777,"MAP2K1, BLNK, NFAT5, AKT1, SYK, NFKBIB, CHUK, CD22, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, GSK3B, AKT2, MAPK1, PIK3CB, CD81, PLCG2",0.255707016877324,0.109578981199086,FALSE +"HCC827","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.23319,0.676,0.885,615,0.972,"TNNC1, EGFR, PLCB4, P2RX4, CAMK2D, ERBB3",0.0530567293021746,0.0123337350737254,FALSE +"HCC827","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.45321,1.26,0.186,2323,0.605,"TNNC1, COX6A1, COX7A2, COX7C, COX5B, COX5A, UQCRH, COX6B1, COX6C, COX7A2L, ATP2A2, COX4I1, SLC9A6, UQCRFS1, COX7B, UQCRB, ATP1B1, UQCRC2, UQCRC1",0.730487055782084,0.218244625347531,FALSE +"HCC827","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.39319,1.11,0.302,592,0.664,"ITGB2, CDH1, CDH15, CDH3, OCLN, CLDN6, CD274, CLDN3, CLDN4, ICAM1, ALCAM, ITGB1, F11R, SDC1, ITGAV, CD276, CNTN1",0.519993057042849,0.177831920631982,FALSE +"HCC827","Input","KEGG_CELL_CYCLE",0.25369,0.723,0.804,926,0.999,"CDKN2A, FZR1, CDK4, TP53, ZBTB17, TFDP2, TGFB2, E2F3, CDC20, CCNA2, CCNB1",0.0947439512515487,0.000434511774017692,FALSE +"HCC827","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.29394,0.855,0.607,1649,0.861,"CXCL5, CX3CL1, PLCB4, RAC2, LYN, GNG12, STAT1, GNG4, ARRB1, CXCR4, GNB3, GNAI1, PIK3R3, STAT2, GNAI3, GNB2, PARD3, PRKCB, RAP1A, GNAI2, KRAS, NRAS, ADCY9",0.216811308924742,0.0649968485463452,FALSE +"HCC827","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.26282,0.75,0.794,704,0.967,"CDKN2A, CDK4, TGFBR2, TP53, TGFB2, E2F3",0.100179497572904,0.0145735259169983,FALSE +"HCC827","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.36444,1.05,0.37,2236,0.689,"DLST, DLAT, SUCLG2, SDHC, OGDHL, PDHB, PDHA1, OGDH, SUCLG1, CS, MDH2, SDHA, SDHB",0.431798275933005,0.161780778092374,FALSE +"HCC827","Input","KEGG_COLORECTAL_CANCER",-0.25449,-0.768,0.719,6269,0.839,"MSH2, CCND1, APPL1, MAP2K1, SMAD4, MAPK8, AKT1, MSH6, SMAD2, CASP3, MAPK3, RAF1, AKT3, BAX, GSK3B, MAPK9, TCF7L1, AKT2, CASP9, MAPK1, PIK3CB",0.143271109617117,0.0762380391712997,FALSE +"HCC827","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.59971,1.72,0.0326,706,0.677,"CFB, SERPINA1, CFI, MBL2, SERPINC1, PROS1, PLAU, TFPI, SERPINF2, F3, F8",1.48678239993206,0.169411331314856,FALSE +"HCC827","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.27524,-0.835,0.631,7177,0.772,"SRM, MAT1A, AHCY, SDS, APIP",0.199970640755866,0.112382699664264,FALSE +"HCC827","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.52324,1.48,0.0911,993,0.409,"CXCL5, EGFR, CX3CL1, TGFBR2, TNFRSF10B, IL6ST, IL10RB, OSMR, MET, TNFRSF10A, LTBR, IL18, TGFB2, CXCR4, TNFRSF21, IL1RAP",1.040481623027,0.388276691992658,FALSE +"HCC827","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.25404,-0.755,0.754,5858,0.854,"RELA, POLR3A, POLR3B, IRF3, RIPK1, POLR3D, IKBKG, NFKBIB, CHUK, TREX1, POLR3C, IKBKB, PYCARD",0.122628654130226,0.068542129310995,FALSE +"HCC827","Input","KEGG_DILATED_CARDIOMYOPATHY",0.51379,1.47,0.0779,660,0.401,"ITGB6, TNNC1, ITGA1, ITGA3, ITGA2, ITGA5, ITGB1, ITGAV, TGFB2",1.10846254232744,0.396855627379818,FALSE +"HCC827","Input","KEGG_DNA_REPLICATION",-0.22458,-0.672,0.869,5811,0.925,"POLA2, MCM7, MCM2, PRIM1, RNASEH2A, PRIM2, RNASEH1, FEN1, RNASEH2C, RNASEH2B",0.0609802235513335,0.0338582672609674,FALSE +"HCC827","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.5855,1.67,0.0392,412,0.333,"EGFR, ETS2, ETS1, ETV6",1.40671393297954,0.47755576649368,FALSE +"HCC827","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.35448,-1.03,0.358,7065,0.667,"MGST2, GSTM2, GSTO1, GSTA4, ALDH3A1, GSTT2, GSTM4, MAOA, GSTM3, MAOB",0.446116973356126,0.175874166083451,FALSE +"HCC827","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.32803,-0.997,0.392,6831,0.705,"UMPS, GMPS, IMPDH1, CES1, CES2, TPMT, UCK2",0.406713932979543,0.151810883008601,FALSE +"HCC827","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.58515,1.69,0.0261,1235,0.439,"ITGB6, TNC, ITGA1, LAMB3, ITGA3, ITGA2, LAMC2, ITGA5, ITGB1, CD47, SDC1, ITGAV, LAMB1, ITGA6, SDC4, LAMA5, COL5A1, AGRN",1.58335949266172,0.357535479757879,FALSE +"HCC827","Input","KEGG_ENDOCYTOSIS",0.22512,0.65,0.898,1759,0.942,"EGFR, RAB11FIP1, RAB31, EPN3, EPN2, MET, ERBB3, RAB11A, ACAP1, ARRB1, CXCR4, RAB11B, EHD1, RAB11FIP5, STAM2, PLD2, PARD3, RAB5B, PSD, SRC, LDLR, CHMP2B, EHD4, PLD1, EHD3, CLTA, AGAP1, RAB22A, RUFY1, RAB5A",0.0467236633326956,0.0259490972071227,FALSE +"HCC827","Input","KEGG_ENDOMETRIAL_CANCER",0.38834,1.11,0.296,425,0.664,"EGFR, CDH1, CTNNB1, TP53, CTNNA1, CTNNA2",0.528708288941061,0.177831920631982,FALSE +"HCC827","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.26233,0.75,0.78,810,0.967,"EGFR, LYN, F11R, JUN, MET, TCIRG1, TJP1, ADAM17",0.10790539730952,0.0145735259169983,FALSE +"HCC827","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.28031,-0.851,0.571,5895,0.783,"BRAF, PAK3, STAT5A, NCK2, PTK2, CRK, BAD, CAMK2G, SOS1, NCK1, RPS6KB2, HBEGF, MAP2K1, MTOR, MAPK8, CBL, AKT1, SHC1, PLCG1, ABL2, MAPK3, RAF1, MAP2K2, AKT3, GSK3B, MAPK9, RPS6KB1, AKT2, MAPK1, CRKL, PIK3CB, PLCG2",0.243363891754152,0.106238237942057,FALSE +"HCC827","Input","KEGG_ETHER_LIPID_METABOLISM",0.58793,1.67,0.0486,1722,0.333,"LPCAT1, PLPP2, PLPP1, PAFAH2, PLA2G12A, PLD2, LPCAT4, PLD1, PLPP3, AGPS",1.31336373073771,0.47755576649368,FALSE +"HCC827","Input","KEGG_FATTY_ACID_METABOLISM",0.30824,0.88,0.597,1362,0.825,"ACADS, ACSL4, CPT2, ACADVL, ALDH1B1, ACOX3, ACAA1, ACADM",0.224025668870631,0.0835460514500749,FALSE +"HCC827","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.34275,-0.99,0.41,6577,0.706,"MAP2K1, MAPK8, AKT1, SYK, PLCG1, PRKCD, MAPK14, MAPK3, RAF1, MAP2K2, AKT3, MAPK9, AKT2, MAPK1, PIK3CB, PLCG2",0.387216143280265,0.151195298948196,FALSE +"HCC827","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.2418,0.695,0.861,552,0.985,"MARCKS, PLPP2, RAC2, LYN, MARCKSL1, AMPH, PLPP1, CFL2",0.0649968485463452,0.00656376950238827,FALSE +"HCC827","Input","KEGG_FOCAL_ADHESION",0.33014,0.937,0.505,545,0.792,"ITGB6, TNC, EGFR, ITGA1, LAMB3, ITGA3, ITGA2, LAMC2, ITGA5, CTNNB1, ITGB1, RAC2, JUN, MET, ITGAV",0.296708621881339,0.101274818410506,FALSE +"HCC827","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.61361,-1.81,0.0267,6548,0.354,"ALPI, ALPP, GGH, DHFR",1.57348873863542,0.450996737974212,FALSE +"HCC827","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.49287,-1.52,0.0786,6011,0.42,"GMDS, ALDOA, PMM1, PFKFB4, ALDOC, PMM2, PFKL, PFKM, PFKFB3, MTMR6, PFKP, MTMR2, AKR1B1, HK3",1.10457745396059,0.3767507096021,FALSE +"HCC827","Input","KEGG_GALACTOSE_METABOLISM",-0.40012,-1.18,0.233,7624,0.597,"GALK1, PFKP, AKR1B1, HK3, GCK",0.632644078973981,0.224025668870631,FALSE +"HCC827","Input","KEGG_GAP_JUNCTION",-0.29238,-0.848,0.594,6779,0.778,"CDK1, ADCY5, ADCY6, ITPR2, CSNK1D, TUBA1B, TUBB1, TUBA3C, TUBB, MAPK3, RAF1, TUBB2A, MAP2K2, TUBB6, TUBAL3, MAPK1, ITPR1, TUBB2B",0.226213555018806,0.109020403010311,FALSE +"HCC827","Input","KEGG_GLIOMA",0.31413,0.894,0.565,704,0.81,"CDKN2A, EGFR, CDK4, TP53, CAMK2D, E2F3",0.247951552180562,0.0915149811213502,FALSE +"HCC827","Input","KEGG_GLUTATHIONE_METABOLISM",-0.37778,-1.14,0.278,6961,0.624,"GGCT, MGST2, GSTM2, SRM, PGD, GSTO1, GSTA4, IDH2, RRM2B, GCLM, ANPEP, RRM2, RRM1, GSTT2, GSTM4, GSTM3",0.555955204081924,0.204815410317576,FALSE +"HCC827","Input","KEGG_GLYCEROLIPID_METABOLISM",0.38497,1.1,0.323,1248,0.667,"LPL, PLPP2, MGLL, PLPP1, ALDH1B1, GLA, GPAT3, MBOAT2, MBOAT1",0.490797477668897,0.175874166083451,FALSE +"HCC827","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33079,0.95,0.476,1567,0.811,"LPCAT1, PEMT, PLPP2, PLPP1, GPD2, GPAT3, PLA2G12A, CDS1, PLD2, LPCAT4, MBOAT2, MBOAT1, PISD, PLD1, PLPP3",0.322393047279507,0.090979145788844,FALSE +"HCC827","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.33729,-1.01,0.384,7312,0.693,"PHGDH, SDS, GCAT, MAOA, MAOB",0.415668775632469,0.159266765388193,FALSE +"HCC827","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.27023,-0.808,0.701,6478,0.804,"ALDOC, BPGM, GPI, PFKL, ALDH7A1, ALDH2, PKLR, PFKM, PKM, PFKP, ACSS2, HK3, ALDH3A1, ACSS1, GCK",0.154281982033341,0.0947439512515487,FALSE +"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.6485,-1.92,0.0242,7319,0.611,"CHST14, CHPF, CHST12",1.61618463401957,0.213958789757446,FALSE +"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.31616,-0.944,0.465,5041,0.735,"HS3ST1, EXT1, B3GALT6, EXTL2, EXT2, GLCE",0.332547047110046,0.133712660915805,FALSE +"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.40808,-1.23,0.214,6954,0.631,"B3GNT2, B4GAT1, B4GALT4, ST3GAL1",0.669586226650809,0.199970640755866,FALSE +"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.63815,1.83,0.0189,1502,1,"GNS, HPSE, IDS, HEXB, SGSH, HEXA",1.72353819582676,0,FALSE +"HCC827","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.3095,-0.904,0.536,7834,0.766,"ST3GAL1",0.27083521030723,0.115771230367396,FALSE +"HCC827","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.59506,1.65,0.0482,1502,0.329,"B3GALT5, GLA, HEXB, HEXA",1.31695296176115,0.482804102050026,FALSE +"HCC827","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.44013,-1.32,0.16,6954,0.514,"B3GNT2, B4GAT1, B4GALT4, FUT3, ST3GAL4",0.795880017344075,0.289036881004724,FALSE +"HCC827","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.64256,-1.91,0.0228,7997,0.476,"PGAP1, PIGM, PIGX",1.64206515299955,0.322393047279507,FALSE +"HCC827","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.25109,-0.74,0.778,2075,0.86,"CS, MDH2, MTHFD1L, MTHFD1, ACO2, MTHFD2, ACO1, PGP, MDH1, GRHPR",0.109020403010311,0.0655015487564323,FALSE +"HCC827","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.22789,0.651,0.912,1649,0.965,"EGFR, PLCB4, JUN, CAMK2D, GNAQ, PLA2G12A, PLD2, MAP2K4, PRKCB, ITPR3, SRC, PLD1, KRAS, NRAS, ADCY9",0.0400051616715838,0.0154726866562074,FALSE +"HCC827","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.24669,0.701,0.844,929,0.991,"CSNK1G1, LRP2",0.073657553374345,0.00392634551472468,FALSE +"HCC827","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.42532,1.22,0.219,201,0.619,"ITGA1, ITGA3, ITGA2, ITGA5",0.659555885159882,0.208309350979882,FALSE +"HCC827","Input","KEGG_HISTIDINE_METABOLISM",-0.49187,-1.45,0.107,7840,0.4,"METTL2B, ALDH3A1, BUD23, LCMT1, MAOA, MAOB",0.97061622231479,0.397940008672038,FALSE +"HCC827","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.20486,-0.599,0.933,6866,0.984,"BLM, TOP3B, MUS81",0.0301183562535,0.00700490156865849,FALSE +"HCC827","Input","KEGG_HUNTINGTONS_DISEASE",0.23112,0.657,0.893,2330,0.983,"PLCB4, SOD2, COX6A1, TP53, COX7A2, CREB1, COX7C, ATP5PF, COX5B, COX5A, GNAQ, UQCRH, COX6B1, NDUFB1, DLG4, COX6C, COX7A2L, ATP5MC2, RCOR1, COX4I1, HTT, NDUFB10, CLTA, SDHC, POLR2D, SLC25A5, SLC25A31, UQCRFS1, CREB5, GPX1, CASP8, POLR2K, COX7B, TFAM, POLR2L, UQCRB, AP2B1, SDHA, SDHB, TAF4, UQCRC2, UQCRC1, CLTB",0.0491485411114536,0.00744648216786438,FALSE +"HCC827","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.53826,1.54,0.0647,660,0.37,"ITGB6, TNNC1, ITGA1, ITGA3, ITGA2, ITGA5, ITGB1, ACE, ITGAV, TGFB2",1.1890957193313,0.431798275933005,FALSE +"HCC827","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.37439,-1.12,0.275,7479,0.618,"CDIPT, PLCD3, PIP5K1A, OCRL, IMPA2, ITPKB, PIK3CB, ITPK1, PLCG2, ITPKA",0.560667306169737,0.209011524911184,FALSE +"HCC827","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.39484,-1.19,0.233,5975,0.595,"TSC1, ACACB, PRKACB, EIF4E2, CRK, PHKG2, BAD, ACACA, INPP5D, PRKCI, SOS1, RPS6KB2, MAP2K1, PRKAR2B, MTOR, MAPK8, PRKAR1A, PHKB, CBL, AKT1, SHC1, PKLR, GYS1, RPTOR, MAPK3, RAF1, PPP1R3D, MAP2K2, AKT3, IKBKB, GSK3B, MAPK9, RPS6KB1, IRS2, AKT2, MAPK1, CRKL, PIK3CB, HK3, SORBS1, GCK",0.632644078973981,0.22548303427145,FALSE +"HCC827","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.5027,-1.48,0.0916,8256,0.394,"CD40",1.03810452633215,0.404503778174426,FALSE +"HCC827","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.25171,0.721,0.821,1605,0.988,"IRF9, IL6ST, STAT1, IL10RB, OSMR, STAM2, PIK3R3, STAT2, JAK1, IFNGR1, SPRY1, IL13RA1",0.0856568428805592,0.00524305541237188,FALSE +"HCC827","Input","KEGG_LEISHMANIA_INFECTION",0.59025,1.68,0.0369,1357,0.401,"PTGS2, ITGB2, ITGB1, MARCKSL1, JUN, STAT1, CYBA, TGFB2, NCF2, JAK1, PRKCB, IFNGR1",1.43297363384094,0.396855627379818,FALSE +"HCC827","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.37798,1.08,0.31,434,0.66,"ITGB2, OCLN, CLDN6, CLDN3, CLDN4, ICAM1, CTNNB1, CTNND1, ITGB1, RAC2, F11R, CTNNA1, CTNNA2, CYBA",0.508638306165727,0.180456064458131,FALSE +"HCC827","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.46478,-1.38,0.118,6702,0.444,"ALDH7A1, ALDH2, EHHADH",0.928117992693875,0.35261702988538,FALSE +"HCC827","Input","KEGG_LONG_TERM_DEPRESSION",0.28927,0.824,0.658,1585,0.88,"PLCB4, LYN, GNAQ, PLA2G12A, GNAI1, GNAI3, PRKCB, ITPR3, GNAI2, KRAS, NRAS",0.181774106386044,0.0555173278498314,FALSE +"HCC827","Input","KEGG_LONG_TERM_POTENTIATION",-0.17933,-0.551,0.99,6899,0.99,"RPS6KA1, ITPR2, MAPK3, RAF1, MAP2K2, MAPK1, ITPR1, CAMK4",0.00436480540245009,0.00436480540245009,FALSE +"HCC827","Input","KEGG_LYSINE_DEGRADATION",0.2399,0.681,0.884,2365,0.979,"TMLHE, PLOD2, DLST, PIPOX, ALDH1B1, SETDB1, EHMT1, SETD2, EHMT2, SETD1B, GCDH, OGDHL, OGDH, SETD1A, ECHS1, HADH, HADHA",0.0535477349869269,0.00921730819686218,FALSE +"HCC827","Input","KEGG_LYSOSOME",0.53598,1.54,0.0865,1582,0.37,"GNS, CTSS, NAPSA, CTSK, CTSO, CTSH, CTSC, AP1M2, IDS, NPC2, FUCA1, LGMN, GAA, AGA, SUMF1, CTSV, AP1B1, TCIRG1, AP1S1, GLA, AP1S3, GALC, PSAP, HEXB, CLN5, IGF2R, LAMP2, GGA3, CD63, ASAH1, SCARB2, M6PR, SGSH, HEXA, AP1G1, LAMP1",1.06298389253519,0.431798275933005,FALSE +"HCC827","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.26069,-0.792,0.703,7088,0.814,"RPS6KA5, CASP3, RELB, NFKB2, MAPK14, MAPKAPK2, MAPK3, RASA1, CD14, TAOK2, RAF1, FLNA, MAP3K11, PPP5C, MAP2K2, AKT3, IKBKB, MAPK9, STK4, AKT2, NLK, MAPK1, CRKL, HSPA2, HSPA1L, STMN1, FGFR1, MAPT, FLNB",0.153044674980176,0.0893755951107988,FALSE +"HCC827","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.63536,-1.94,0.0155,6310,0.836,"IAPP, PKLR, MNX1, GCK",1.80966830182971,0.0777937225609836,FALSE +"HCC827","Input","KEGG_MELANOGENESIS",0.23385,0.655,0.892,1649,0.973,"CTNNB1, PLCB4, CAMK2D, CREB1, GNAQ, GNAI1, GNAI3, ASIP, PRKCB, GNAI2, KRAS, NRAS, ADCY9",0.0496351456238769,0.0118871597316481,FALSE +"HCC827","Input","KEGG_MELANOMA",0.40989,1.19,0.209,704,0.635,"CDKN2A, EGFR, CDH1, CDK4, TP53, MET, E2F3",0.679853713888946,0.197226274708024,FALSE +"HCC827","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.35663,-1.07,0.328,7065,0.657,"MGST2, GSTM2, GSTO1, GSTA4, AKR1C3, AKR1C1, ALDH3A1, GSTT2, GSTM4, GSTM3",0.484126156288321,0.182434630440219,FALSE +"HCC827","Input","KEGG_MISMATCH_REPAIR",-0.18696,-0.564,0.974,1543,0.994,"POLD4, SSBP1, RFC1, POLD3, RFC4, LIG1, RFC5, POLD2, POLD1, RFC2, MSH3, RFC3, RPA2, RPA1, PCNA, PMS2, RPA3, MLH3, MLH1, MSH2, MSH6",0.0114410431213845,0.00261361560268669,FALSE +"HCC827","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.4814,-1.47,0.0933,5510,0.391,"PRKAA1, RHEB, MLST8, TSC2, RPS6, BRAF, TSC1, EIF4E2, RPS6KB2, MTOR, STK11, AKT1, RPS6KA1, RICTOR, RPTOR, MAPK3, AKT3, RPS6KB1, AKT2, MAPK1, PIK3CB",1.0301183562535,0.407823242604133,FALSE +"HCC827","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.27935,-0.831,0.627,7315,0.77,"TNFRSF10D, MAPK3, IFNAR1, RAF1, MAP2K2, MAPK1, PIK3CB, PRF1, ZAP70, BID, PLCG2",0.202732459169284,0.113509274827518,FALSE +"HCC827","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.31793,0.927,0.529,538,0.784,"P2RX4, CHRNE",0.276544327964814,0.105683937315562,FALSE +"HCC827","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.38899,-1.15,0.274,6253,0.622,"MAP3K3, CAMK2G, SOS1, MAGED1, IRAK4, MAP2K1, MAP3K5, MAPK8, AKT1, SHC1, PLCG1, NFKBIB, RPS6KA1, PRKCD, RPS6KA5, ARHGDIA, MAPK14, MAPKAPK2, MAPK3, RAF1, MAP2K2, AKT3, BAX, IKBKB, GSK3B, MAPK9, IRS2, AKT2, MAPK1, CRKL, PIK3CB, CSK, CAMK4, NGFR, PLCG2",0.562249437179612,0.206209615309181,FALSE +"HCC827","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.32533,-0.987,0.369,8169,0.699,"NMNAT3, QPRT",0.43297363384094,0.155522824254319,FALSE +"HCC827","Input","KEGG_NITROGEN_METABOLISM",-0.58679,-1.79,0.0276,7138,0.336,"CPS1, CA12, CA1, CA8, GLUD2, CA2",1.55909091793478,0.473660722610156,FALSE +"HCC827","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.38359,-1.19,0.234,5818,0.595,"MAP3K7, RELA, BIRC2, TAB1, IKBKG, MAPK8, SUGT1, NFKBIB, CHUK, HSP90AB1, XIAP, MAPK14, MAPK3, IKBKB, TAB3, MAPK9, MAPK1, PYCARD",0.630784142589857,0.22548303427145,FALSE +"HCC827","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.50889,-1.51,0.0877,6148,0.411,"LIG4, PRKDC, NHEJ1, XRCC6, XRCC5, FEN1",1.05700040663396,0.386158178123931,FALSE +"HCC827","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.29756,0.849,0.659,338,0.858,"CDKN2A, EGFR, CDK4, TP53",0.18111458540599,0.0665127121512946,FALSE +"HCC827","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.45648,1.28,0.176,1537,0.615,"DLL3, DTX3L, RBPJ, NUMB, ADAM17, MAML3, NCSTN, DTX2, NOTCH2, NOTCH3",0.75448733218585,0.211124884224583,FALSE +"HCC827","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.29662,-0.868,0.557,5133,0.77,"PCNA, ERCC2, RAD23B, GTF2H5, RPA3, GTF2H2, CUL4B, GTF2H4, CETN2, CDK7, GTF2H1, ERCC1, ERCC6, CCNH, ERCC4, RAD23A, CUL4A, DDB2, XPC, XPA",0.254144804826271,0.113509274827518,FALSE +"HCC827","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.24031,0.681,0.877,2078,0.979,"ST6GAL1, FUT8, DOLPP1, MAN1A2, B4GALT1, RPN2, DPM1, ALG6, STT3A, ALG13, MAN2A1",0.0570004066339595,0.00921730819686218,FALSE +"HCC827","Input","KEGG_OLFACTORY_TRANSDUCTION",0.4055,1.15,0.268,2497,0.637,"CAMK2D, PDC, CAMK2B, PRKACA, CNGB1",0.571865205971211,0.19586056766465,FALSE +"HCC827","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.42156,-1.22,0.221,7990,0.63,"DHFR, TYMS",0.655607726314889,0.200659450546418,FALSE +"HCC827","Input","KEGG_OOCYTE_MEIOSIS",-0.36914,-1.06,0.364,5763,0.623,"SMC3, CDC26, SKP1, SMC1A, MAD2L1, ANAPC4, PRKACB, CCNB2, YWHAZ, PLK1, CAMK2G, PPP2R5C, PPP2R1B, ANAPC1, MAP2K1, PPP2R5A, SMC1B, CDC27, CDK1, ADCY5, PPP2CB, RPS6KA1, PPP2R5D, ADCY6, ITPR2, ANAPC7, PKMYT1, CUL1, MAPK3, CDC23, CDC16, ANAPC5, MAPK1, STAG3, ITPR1, CDK2, MAD2L2",0.438898616350944,0.20551195334083,FALSE +"HCC827","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.60295,1.71,0.0457,1907,0.565,"FUCA1, AGA, FUCA2, MAN2B2, HEXB, HEXA, MANBA, GBA",1.34008379993015,0.247951552180562,FALSE +"HCC827","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.22541,0.65,0.911,2323,0.942,"COX6A1, PPA2, COX7A2, COX11, COX17, TCIRG1, COX7C, ATP5PF, COX5B, COX5A, UQCRH, COX6B1, NDUFB1, COX6C, LHPP, COX7A2L, ATP5MC2, COX4I1, NDUFB10, SDHC, UQCRFS1, COX7B, UQCRB, SDHA, SDHB, ATP6V1C1, ATP6AP1, UQCRC2, UQCRC1",0.0404816230270017,0.0259490972071227,FALSE +"HCC827","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.62067,1.74,0.035,1051,0.83,"GALNT4, GALNT8, GALNT13, GALNT7, GALNT5, GALNT3, GALNT6, GALNT15, GALNT2, C1GALT1C1",1.45593195564972,0.0809219076239261,FALSE +"HCC827","Input","KEGG_P53_SIGNALING_PATHWAY",0.26742,0.758,0.737,559,0.982,"CDKN2A, CDK4, TP53, TNFRSF10B, RCHY1",0.132532512140949,0.00788851221305034,FALSE +"HCC827","Input","KEGG_PANCREATIC_CANCER",0.37719,1.08,0.33,751,0.66,"CDKN2A, EGFR, CDK4, RAC2, TGFBR2, TP53, STAT1, TGFB2, E2F3, RALB",0.481486060122112,0.180456064458131,FALSE +"HCC827","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.5803,-1.69,0.0461,6522,0.317,"PPCDC, COASY, ENPP1, PANK4, PANK1",1.33629907461035,0.498940737782249,FALSE +"HCC827","Input","KEGG_PARKINSONS_DISEASE",0.175,0.503,0.987,1852,0.992,"UBE2L6, UBA7, COX6A1, COX7A2, COX7C, ATP5PF, COX5B, COX5A, UQCRH, COX6B1, NDUFB1, COX6C, HTRA2, COX7A2L, ATP5MC2, COX4I1, NDUFB10, SDHC, SLC25A5, SLC25A31, UQCRFS1",0.00568284733036327,0.00348832784582135,FALSE +"HCC827","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.3019,-0.901,0.548,6006,0.761,"NCK2, ARPC4, YWHAZ, ROCK2, ARPC1B, EZR, NCK1, ACTB, ARPC3, ARPC2, ROCK1, ARPC5, TUBA1B, TUBB1, TUBA3C, TUBB, ACTG1, CD14, TUBB2A, TUBB6, WAS, TUBAL3, ARHGEF2, HCLS1, TUBB2B",0.261219441515631,0.118615343229427,FALSE +"HCC827","Input","KEGG_PATHWAYS_IN_CANCER",0.33588,0.971,0.465,751,0.78,"PTGS2, CDKN2A, EGFR, PML, CDH1, CDK4, LAMB3, ITGA3, ITGA2, ETS1, LAMC2, CTNNB1, ITGB1, RAC2, TGFBR2, TP53, CTNNA1, JUN, CTNNA2, STAT1, MET, ITGAV, TGFB2, E2F3, LAMB1, RALB",0.332547047110046,0.10790539730952,FALSE +"HCC827","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.50903,-1.56,0.0649,7333,0.39,"CRYL1, DCXR, AKR1B1",1.18775530319963,0.408935392973501,FALSE +"HCC827","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.56712,-1.7,0.0375,6180,0.329,"ALDOA, PGM2, ALDOC, PGLS, GPI, PFKL, PRPS1, PRPS1L1, PRPS2, PFKM, PGD, PFKP, TALDO1",1.42596873227228,0.482804102050026,FALSE +"HCC827","Input","KEGG_PEROXISOME",0.39293,1.13,0.298,1309,0.659,"SOD2, ACSL4, ACOT8, SCP2, HMGCL, DHRS4, NUDT12, EPHX2, PIPOX, PEX13, SLC27A2, ACOX3, PAOX, HACL1, PECR, ABCD3, ACAA1, PEX3, ECH1",0.525783735923745,0.18111458540599,FALSE +"HCC827","Input","KEGG_PHENYLALANINE_METABOLISM",-0.5462,-1.68,0.0447,7974,0.288,"ALDH3A1, MAOA, MAOB",1.34969247686806,0.540607512240769,FALSE +"HCC827","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.36504,-1.06,0.326,6827,0.623,"SYNJ1, PLCG1, INPP5A, ITPR2, PIP5K1C, DGKH, CDIPT, PLCD3, PIP5K1A, OCRL, IMPA2, ITPKB, ITPR1, DGKQ, PIK3CB, ITPK1, PLCG2, ITPKA",0.486782399932061,0.20551195334083,FALSE +"HCC827","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.36031,1.03,0.389,1755,0.701,"CP, ALAD, HMOX2, FTH1, ALAS1, HCCS",0.410050398674292,0.154281982033341,FALSE +"HCC827","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.33219,-0.969,0.437,7762,0.709,"ME1, FABP7, FADS2, SORBS1, GK, CPT1A, CYP27A1, EHHADH",0.359518563029578,0.149353764816933,FALSE +"HCC827","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.60303,-1.86,0.0325,7800,0.388,"AKR1D1, CYP27A1",1.48811663902113,0.411168274405793,FALSE +"HCC827","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.54231,-1.62,0.0703,6426,0.336,"IKBKG, RFX5, JAK3, BLNK, ZAP70, CD40",1.15304467498018,0.473660722610156,FALSE +"HCC827","Input","KEGG_PRION_DISEASES",-0.59536,-1.82,0.0236,7092,0.392,"NOTCH1, MAPK3, MAP2K2, BAX, SOD1, MAPK1, C9, NCAM1",1.62708799702989,0.406713932979543,FALSE +"HCC827","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.35668,-1.06,0.338,6539,0.623,"ANAPC1, MAP2K1, MAPK8, AKT1, CDC27, CDK1, ADCY5, RPS6KA1, ADCY6, ANAPC7, HSP90AB1, PKMYT1, MAPK14, MAPK3, CDC23, RAF1, AKT3, MAPK9, CDC16, ANAPC5, AKT2, MAPK1, CDK2, PIK3CB, MAD2L2",0.471083299722345,0.20551195334083,FALSE +"HCC827","Input","KEGG_PROPANOATE_METABOLISM",-0.36247,-1.06,0.354,7705,0.623,"ACAT2, ACSS2, ACSS1, ACSS3, EHHADH",0.450996737974212,0.20551195334083,FALSE +"HCC827","Input","KEGG_PROSTATE_CANCER",-0.26497,-0.787,0.694,6273,0.813,"SOS1, CCND1, IKBKG, MAP2K1, MTOR, AKT1, CHUK, RB1, HSP90AB1, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, GSK3B, TCF7L1, AKT2, CASP9, MAPK1, CDK2, PIK3CB, FGFR1",0.158640529545145,0.0899094544059319,FALSE +"HCC827","Input","KEGG_PROTEASOME",0.36334,1.05,0.374,474,0.689,"PSMB10, PSMB9, PSMB8",0.42712839779952,0.161780778092374,FALSE +"HCC827","Input","KEGG_PROTEIN_EXPORT",0.19957,0.579,0.973,1782,0.977,"OXA1L, SRPRA, HSPA5, SRPRB",0.0118871597316481,0.0101054362812269,FALSE +"HCC827","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.59592,-1.75,0.0408,7909,0.325,"ATP1B3, GLUD2, CA2",1.38933983691012,0.488116639021126,FALSE +"HCC827","Input","KEGG_PURINE_METABOLISM",-0.35688,-1.07,0.327,6266,0.657,"PRIM1, NT5C2, POLR3D, ADSL, PAPSS1, NT5C, AMPD3, PRIM2, PRPS1, PRPS1L1, ADCY5, PKLR, AMPD2, POLR3C, PRPS2, ADCY6, PAICS, NME7, GMPS, PPAT, ENPP1, DCK, AK5, IMPDH1, ENTPD4, NT5C3A, PKM, ENTPD8, GMPR, NUDT2, PDE4D, PDE8A, NME4, RRM2B, RRM2, NUDT5, RRM1, POLR2F",0.485452247339714,0.182434630440219,FALSE +"HCC827","Input","KEGG_PYRIMIDINE_METABOLISM",-0.23456,-0.703,0.81,6831,0.89,"UMPS, POLR3C, NME7, DCK, CTPS2, ENTPD4, NT5C3A, ENTPD8, NUDT2, DUT, NME4, RRM2B, RRM2, UCK2, RRM1, TYMS, POLR2F",0.0915149811213502,0.0506099933550872,FALSE +"HCC827","Input","KEGG_PYRUVATE_METABOLISM",-0.36411,-1.07,0.33,6232,0.657,"ACACA, MDH1, GRHPR, PC, ALDH7A1, ALDH2, PKLR, GLO1, PKM, ACYP2, HAGH, ACAT2, ACSS2, ME1, AKR1B1, ACSS1",0.481486060122112,0.182434630440219,FALSE +"HCC827","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.32198,0.922,0.507,552,0.78,"ITGB6, PIP4K2C, ITGB2, EGFR, ITGA1, ITGA3, ITGA2, ITGA5, ITGB1, RAC2, GNG12, ITGAV, CFL2",0.294992040666664,0.10790539730952,FALSE +"HCC827","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.24024,-0.715,0.828,5510,0.892,"PRKAA1, ATG3, ATG7, ATG4B",0.0819696632151199,0.0496351456238769,FALSE +"HCC827","Input","KEGG_RENAL_CELL_CARCINOMA",-0.21373,-0.64,0.907,7197,0.954,"EGLN1, MAPK3, RAF1, MAP2K2, AKT3, AKT2, MAPK1, CRKL, PIK3CB",0.0423927129399047,0.0204516252959049,FALSE +"HCC827","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.40697,-1.2,0.212,7860,0.612,"ANPEP, MME",0.673664139071249,0.213248577854439,FALSE +"HCC827","Input","KEGG_RETINOL_METABOLISM",0.54332,1.55,0.07,1049,0.411,"RDH10, DHRS3, DHRS4, PNPLA4, RDH11",1.15490195998574,0.386158178123931,FALSE +"HCC827","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.43527,-1.31,0.161,6704,0.513,"ACP2, ENPP1, MTMR6, TYR, MTMR2",0.79317412396815,0.289882634888184,FALSE +"HCC827","Input","KEGG_RIBOSOME",-0.5251,-1.5,0.0964,5682,0.387,"RPS25, RPL21, RPL34, RPL32, RPS28, RPL5, RPL36, RPS2, RPL28, RPS7, RPS8, RPS6, RPL17, RPL7, RPL10, RPL15, RPL6, RPL26, RPL35A, RPL3, RPL23A, RPL10A, RPL12, RPL19, RPLP0, RPL13A, RPS10, UBA52, RPL4, RPS26, RPS17, RPL30, RPS15, RPL7A, RPS11, RPS3A, RPL31, RPS24, RPL18A, RPS19, RPL9, RPS15A, RPS13, RPS9, RPS5, RPS16, RPS3, RPL14, RPS4X, RPS27L, RPL22, RPL8, RPL27A, RPS20, RPL35, RPS18, RPL26L1",1.01592296609717,0.412289034981089,FALSE +"HCC827","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.39221,-1.2,0.214,8272,0.612,"DDX3Y",0.669586226650809,0.213248577854439,FALSE +"HCC827","Input","KEGG_RNA_DEGRADATION",-0.14669,-0.434,1,1866,0.999,"HSPD1, LSM6, LSM2, LSM3, LSM8, HSPA9, XRN2, CNOT2, LSM7, PATL1, EXOSC5, DCP1B, ENO1, DCP1A, EXOSC1, DCP2, EDC3, LSM4, EXOSC2, TTC37, MTREX, SKIV2L, WDR61, EXOSC4, CNOT3, EXOSC3, EDC4, EXOSC7, ENO3, EXOSC8, CNOT7, DIS3, PAPOLG, CNOT10, ENO2, MPHOSPH6, EXOSC9, C1D, PAPOLA, EXOSC6, ZCCHC7, EXOSC10, CNOT4, CNOT1, PARN, XRN1, DCPS, CNOT9, DDX6, LSM1",0,0.000434511774017692,FALSE +"HCC827","Input","KEGG_RNA_POLYMERASE",-0.30648,-0.907,0.553,8204,0.784,"POLR2F",0.257274868695302,0.105683937315562,FALSE +"HCC827","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.33493,-0.98,0.44,7042,0.701,"SEPHS2, MAT1A, AHCY, SEPHS1, METTL2B, BUD23, LCMT1",0.356547323513813,0.154281982033341,FALSE +"HCC827","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.43864,1.25,0.189,1123,0.603,"PTGS2, CDK4, LAMB3, ITGA3, ITGA2, LAMC2, ITGB1, TP53, ITGAV, E2F3, LAMB1, ITGA6, MAX, LAMA5, PIK3R3",0.723538195826756,0.219682687859849,FALSE +"HCC827","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.41152,1.16,0.277,2182,0.656,"STX17, VAMP8, STX18, STX3, STX6, BNIP1, STX8, STX12, GOSR1, VTI1B, SEC22B, SNAP47, STX7",0.557520230935551,0.18309616062434,FALSE +"HCC827","Input","KEGG_SPHINGOLIPID_METABOLISM",0.49217,1.4,0.123,2056,0.465,"PLPP2, PLPP1, UGT8, GLA, GALC, ASAH1, PLPP3, SPHK2, GBA, SMPD1, SPTLC1",0.910094888560602,0.332547047110046,FALSE +"HCC827","Input","KEGG_SPLICEOSOME",0.27832,0.789,0.706,3534,0.936,"HNRNPA1, SRSF7, SNRNP27, ACIN1, HNRNPM, SF3B5, PRPF40A, NCBP2, ZMAT2, HNRNPU, SART1, PRPF19, PRPF4, WBP11, SRSF5, TRA2A, SNRNP40, DHX38, CWC15, LSM6, SRSF6, LSM2, LSM3, U2AF2, CDC5L, U2AF1, SNRPF, SNRPG, SNRNP70, HNRNPA3, SRSF10, LSM8, BCAS2, SNRPB, RBM25, PRPF31, PRPF38B, SF3B6, SF3A1, PRPF38A, HSPA6, SRSF9, HNRNPC, SNRPC, TRA2B, SF3B2, SF3B3, HNRNPK, LSM7, PQBP1, DDX5, SNW1, SNRPA, TCERG1, DDX23, PUF60, SLU7, XAB2, PLRG1, EFTUD2, SRSF3, SF3A2, DDX39B, SNU13, SRSF1, SNRPD3, TXNL4A, RBM8A, PPIL1, PPIH, PHF5A, SF3A3",0.151195298948196,0.0287241512618947,FALSE +"HCC827","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.33452,0.939,0.498,846,0.803,"PGM2L1, GAA, UGDH, UXS1, PYGL",0.302770657240282,0.095284454721319,FALSE +"HCC827","Input","KEGG_STEROID_BIOSYNTHESIS",-0.36869,-1.1,0.319,6533,0.642,"CYP51A1, LSS, CEL, LIPA, MSMO1, SOAT2, SQLE",0.496209316942819,0.192464971931147,FALSE +"HCC827","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.46991,-1.39,0.13,6750,0.446,"SRD5A1, CYP21A2, COMT, HSD17B2, SULT2B1, AKR1C3, AKR1D1, AKR1C1",0.886056647693163,0.350665141287858,FALSE +"HCC827","Input","KEGG_SULFUR_METABOLISM",-0.55821,-1.68,0.0422,7685,0.288,"SULT2B1, SULT1A1, CHST12",1.37468754903833,0.540607512240769,FALSE +"HCC827","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.51444,-1.5,0.0913,6007,0.387,"ACTN4, ACTN1, ACTN2, C4A, C9, CD40",1.0395292224657,0.412289034981089,FALSE +"HCC827","Input","KEGG_TASTE_TRANSDUCTION",0.48765,1.4,0.116,2777,0.465,"SCNN1A, GNB3, ITPR3, GNB1, PRKACA, KCNB1, CACNA1A",0.935542010773082,0.332547047110046,FALSE +"HCC827","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.64977,-1.96,0.016,6772,1,"GGPS1, MVK, ACAT2, PMVK, HMGCS1, FDPS, IDI1",1.79588001734408,0,FALSE +"HCC827","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.31245,-0.926,0.461,6369,0.759,"PPP2R1B, RPS6KB2, SMAD1, SMAD4, ROCK1, SMAD5, PPP2CB, SMAD2, SMAD9, CUL1, MAPK3, INHBE, RPS6KB1, THBS2, MAPK1, ID1",0.336299074610352,0.11975822410452,FALSE +"HCC827","Input","KEGG_THYROID_CANCER",0.40571,1.17,0.244,338,0.656,"CDH1, CTNNB1, TP53",0.612610173661271,0.18309616062434,FALSE +"HCC827","Input","KEGG_TIGHT_JUNCTION",0.45473,1.27,0.188,1351,0.61,"CDK4, OCLN, EPB41L1, CLDN6, RAB3B, CLDN3, CLDN4, CTNNB1, CGN, F11R, TJP2, CTNNA1, CTNNA2, TJP3, TJP1, MPDZ, AFDN, PATJ, LLGL1, GNAI1, GNAI3, CASK, EXOC4, CLDN1, PARD3, PRKCB, SRC",0.72584215073632,0.214670164989233,FALSE +"HCC827","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.32552,-0.957,0.428,6198,0.721,"TAB1, IRF3, RIPK1, IKBKG, IRAK4, TRAF3, MAP2K1, MAPK8, AKT1, CHUK, MAPK14, MAPK3, IFNAR1, CD14, MAP2K2, AKT3, IKBKB, MAPK9, AKT2, MAPK1, PIK3CB, LBP, CD40",0.368556230986828,0.142064735280571,FALSE +"HCC827","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.47167,-1.42,0.116,7705,0.421,"ACAT2, AADAT, MAOA, MAOB, EHHADH",0.935542010773082,0.375717904164332,FALSE +"HCC827","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.63282,-1.88,0.031,6598,0.432,"MTOR, MAPK8, PKLR, PRKCD, MAPK3, PKM, IKBKB, MAPK9, IRS2, MAPK1, PIK3CB, HK3, GCK",1.50863830616573,0.364516253185088,FALSE +"HCC827","Input","KEGG_TYROSINE_METABOLISM",-0.59036,-1.76,0.0353,7770,0.342,"TYR, METTL2B, DCT, ALDH3A1, BUD23, LCMT1, MAOA, MAOB",1.45222529461218,0.465973893943865,FALSE +"HCC827","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.29288,-0.87,0.583,6273,0.778,"SOS1, NCK1, PRKCQ, IKBKG, MAP2K1, NFAT5, CBL, AKT1, PLCG1, NFKBIB, CHUK, MAPK14, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, GSK3B, MAPK9, AKT2, MAPK1, PIK3CB, ZAP70",0.234331445240986,0.109020403010311,FALSE +"HCC827","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.30347,-0.883,0.513,6766,0.786,"CDC27, FANCL, CUL7, HUWE1, UBE2F, UBE2E1, CDC34, CUL4A, ANAPC7, SAE1, MID1, DDB2, CUL1, UBE2Q1, PIAS1, PPIL2, XIAP, UBA1, UBE2E3, UBE2G2, CDC23, PIAS4, UBE2S, UBE2B, FBXW7, UBE3A, HERC1, PIAS2, RNF7, CDC16, UBE2L3, ANAPC5, UBA2, UBE2M, HERC4, FBXO2",0.289882634888184,0.104577453960592,FALSE +"HCC827","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.29309,0.84,0.655,2807,0.862,"PDHB, PDHA1, IARS2",0.183758700008217,0.0644927341752872,FALSE +"HCC827","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.37663,1.08,0.314,1450,0.66,"ACADS, IVD, HMGCL, ACAD8, DBT, ALDH1B1, MCCC1, AUH, ACAA1, HIBCH, HIBADH, MCCC2, ACADM, ALDH6A1",0.503070351926785,0.180456064458131,FALSE +"HCC827","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.29063,-0.845,0.587,6004,0.774,"ACTA2, PRKACB, PLCB1, ROCK2, MYH11, PRKCQ, MAP2K1, ROCK1, ADCY5, ADCY6, ITPR2, PRKCD, MAPK3, RAF1, MAP2K2, MAPK1, ITPR1, ARHGEF1, ARHGEF11, KCNMA1",0.231361898752386,0.111259039317107,FALSE +"HCC827","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.33272,0.941,0.498,2090,0.815,"ARHGDIB, RAB11A, CREB1, RAB11B, DYNC1LI2, RAB5B, DYNLL2, ADCY9, RAB5A, CREB5, RAB5C",0.302770657240282,0.0888423912600234,FALSE +"HCC827","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.28054,-0.855,0.602,7259,0.786,"MAPK14, MAPKAPK2, MAPK3, RAF1, MAP2K2, AKT3, AKT2, CASP9, MAPK1, PIK3CB, PLCG2",0.220403508742175,0.104577453960592,FALSE +"HCC827","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.20452,0.582,0.972,1059,0.988,"ERO1A, TJP2, TCIRG1, TJP1, SLC12A2, PDIA4",0.0123337350737254,0.00524305541237188,FALSE +"HCC827","Input","KEGG_VIRAL_MYOCARDITIS",0.32775,0.927,0.52,255,0.784,"ITGB2, CXADR, ICAM1, RAC2",0.283996656365201,0.105683937315562,FALSE +"HCC827","Input","KEGG_WNT_SIGNALING_PATHWAY",0.31177,0.898,0.571,678,0.817,"CTNNB1, LRP5, PLCB4, RAC2, TP53, JUN, CAMK2D, DAAM1, DAAM2, CHD8",0.243363891754152,0.0877779434675845,FALSE +"HCC95","Input","KEGG_ABC_TRANSPORTERS",0.39284,1.15,0.275,1732,0.659,"ABCC5, ABCC8, ABCC3, ABCC1, ABCC4, TAP1, ABCB10, TAP2, ABCB6, ABCC2",0.560667306169737,0.18111458540599,FALSE +"HCC95","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.28754,0.841,0.635,1460,0.785,"PML, IKBKB, KRAS, NRAS, RARA, HRAS, BAD, MYC, EIF4EBP1, STAT3",0.197226274708024,0.105130343254747,FALSE +"HCC95","Input","KEGG_ADHERENS_JUNCTION",0.34188,1.01,0.403,1106,0.724,"NECTIN1, EGFR, YES1, IGF1R, PTPN6, RAC2, SMAD3, RAC3, SRC, CTNND1, ACTN4, MET",0.39469495385889,0.140261433802853,FALSE +"HCC95","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.29338,0.882,0.559,822,0.818,"SLC2A1, RXRA, IKBKB, IRS1, PCK2",0.252588192113577,0.087246696328677,FALSE +"HCC95","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.32401,-0.938,0.502,7877,0.831,"CPS1, GPT, GLS, GLS2, GLUD2",0.299296282854981,0.080398976215889,FALSE +"HCC95","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.28782,0.859,0.593,1227,0.786,"ATP1B3, IRS1, KRAS, ATP1A3, ATP1B1, ATP1A1, ATP1A4, SFN",0.226945306635737,0.104577453960592,FALSE +"HCC95","Input","KEGG_ALZHEIMERS_DISEASE",-0.32101,-0.914,0.514,6408,0.856,"FADD, COX7A2, COX4I1, NDUFS2, UQCRQ, NDUFA3, LPL, GSK3B, NDUFAB1, APH1A, NCSTN, CASP3, COX5A, NDUFB4, PPP3CC, MME, MAPK1, NDUFB7, COX6C, NDUFA2, EIF2AK3, MAPK3, COX7C, CAPN2, HSD17B10, CYCS, CALM2, PPP3R1, PPP3R2, PSEN2, COX7B, APOE, PSEN1, BACE2, ATP5MC2",0.289036881004724,0.0675262353228468,FALSE +"HCC95","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.34247,-1.02,0.378,5695,0.786,"PARS2, FARSB, TARS2, AARS2, LARS2, FARS2, YARS2, FARSA, EARS2, MARS2, CARS2",0.422508200162775,0.104577453960592,FALSE +"HCC95","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.40248,-1.16,0.248,6876,0.717,"UGP2, GMPPB, GALK1, CYB5R3, GALK2, GNPNAT1, PMM2, GMDS, AMDHD2, RENBP, NAGK, GALT, GNE, GCK, PGM1, UAP1",0.605548319173784,0.1444808443322,FALSE +"HCC95","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.32409,-0.945,0.467,7912,0.845,"NEFL, RAB5A, TOMM40L, MAP3K5, CYCS, PPP3R1, PPP3R2, NEFH, PRPH, PRPH2",0.330683119433888,0.0731432910503077,FALSE +"HCC95","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.38863,1.14,0.265,2128,0.64,"CTSB, TAPBP, B2M, NFYB, HSPA5, NFYA, TAP1, PSME1, TAP2, PSME2, HSPA1A, CANX, CTSL, NFYC, HSPA6, PSME3",0.576754126063192,0.193820026016113,FALSE +"HCC95","Input","KEGG_APOPTOSIS",-0.30823,-0.904,0.518,7082,0.837,"CASP3, AKT3, PPP3CC, IRAK4, CASP6, PRKACA, PRKAR2B, AIFM1, AKT1, EXOG, MYD88, CAPN2, PIK3CB, CYCS, PPP3R1, PPP3R2, PRKACB, RIPK1",0.285670240254767,0.07727454200674,FALSE +"HCC95","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.43307,1.3,0.16,1264,0.578,"AKR1C3, CYP4F3, CBR1, EPHX2, GPX2, PTGS2, ALOX5, CBR3, PTGES2",0.795880017344075,0.238072161579471,FALSE +"HCC95","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34959,1.05,0.362,1592,0.72,"CKMT1A, CKMT2, ODC1, ASS1, PYCR2, SAT2, GATM, PYCR1, ARG1, P4HA2, OTC, ALDH4A1, GOT2, ALDH2, MAOA, GLUL, SAT1, PRODH, PRODH2, ALDH3A2",0.441291429466834,0.142667503568732,FALSE +"HCC95","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.31875,0.925,0.494,622,0.783,"ITGB4, GJA1, ITGA2, ITGA6, ITGA5, ITGA3, CDH2, ITGB8",0.306273051076353,0.106238237942057,FALSE +"HCC95","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.69405,-2.05,0.00929,8524,0.235,"ALDH9A1, ALDH7A1",2.03198428600636,0.628932137728264,TRUE +"HCC95","Input","KEGG_AXON_GUIDANCE",0.36922,1.09,0.301,1256,0.689,"EFNA5, EFNB1, UNC5B, SEMA4D, SEMA4B, SEMA5B, PLXNB2, EFNB2, EPHA2, ROBO2, RAC2, NTN4, EFNB3, PLXNA2, EPHB3, KRAS, NRAS, RAC3, SEMA3C, NCK1, HRAS, MET, EPHA6, SLIT1, SLIT3, NTN1",0.521433504406157,0.161780778092374,FALSE +"HCC95","Input","KEGG_BASAL_CELL_CARCINOMA",0.50903,1.51,0.0805,1596,0.365,"FZD1, WNT5A, FZD6, FZD2, DVL3, TP53",1.09420411963213,0.437707135543525,FALSE +"HCC95","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.50586,1.5,0.0789,2318,0.36,"TAF7, TAF1, GTF2A2, TAF2, GTF2F2, GTF2B, GTF2H1, GTF2H4, GTF2H3, TAF9, TAF6, TBPL1",1.10292299679058,0.443697499232713,FALSE +"HCC95","Input","KEGG_BASE_EXCISION_REPAIR",0.51717,1.53,0.0847,3256,0.359,"POLB, PARP2, POLD3, APEX1, POLD4, POLE, POLD1, LIG3, TDG, POLE4, POLD2, HMGB1, PARP1, XRCC1, POLE3, FEN1, MPG, MBD4, PCNA",1.07211658966929,0.444905551421681,FALSE +"HCC95","Input","KEGG_BETA_ALANINE_METABOLISM",-0.6157,-1.73,0.0406,8121,0.266,"SRM, SMS, ALDH9A1, ALDH7A1",1.39147396642281,0.575118363368933,FALSE +"HCC95","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.54086,-1.59,0.0621,7833,0.275,"ACOT7, ACOT2, PECR, ACOX3, YOD1, ACAA1, ACOT1, ACOT4",1.20690839982342,0.560667306169737,FALSE +"HCC95","Input","KEGG_BLADDER_CANCER",0.43275,1.27,0.183,1129,0.588,"EGFR, KRAS, NRAS, THBS1, RPS6KA5, RB1, HRAS, MYC",0.737548910269571,0.230622673923862,FALSE +"HCC95","Input","KEGG_BUTANOATE_METABOLISM",-0.33985,-0.984,0.42,7232,0.804,"AACS, PDHA1, PDHB, BDH2, ACAT1, ALDH9A1, ALDH7A1",0.3767507096021,0.0947439512515487,FALSE +"HCC95","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.25152,-0.747,0.775,6772,0.895,"NFKBIB, GSK3B, AKT2, NFAT5, AKT3, CD81, PPP3CC, MAPK1, PIK3AP1, MAPK3, SOS1, AKT1, INPP5D, PIK3CB, PPP3R1, PPP3R2, PRKCB, NFATC2",0.11069829749369,0.048176964684088,FALSE +"HCC95","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.29773,-0.872,0.605,8274,0.853,"MYLK, CALM2, PPP3R1, ERBB3, PPP3R2, PRKACB, PRKCB, SPHK2, CACNA1A, BST1, PDE1C",0.218244625347531,0.069050968832477,FALSE +"HCC95","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.27473,-0.816,0.659,6417,0.857,"COX7A2, COX4I1, CACNB2, UQCRQ, TPM4, TPM1, SLC8A1, COX5A, COX6C, MYL3, SLC9A6, CACNA2D1, COX7C, TPM3, TPM2, COX7B",0.18111458540599,0.0670191780768018,FALSE +"HCC95","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.50287,1.48,0.0902,444,0.349,"NECTIN1, CLDN11, SDC1, JAM3, CDH4, CNTN1, CLDN6, CD40, ITGA6, CD274, CLDN1, CNTNAP1, CDH2, ALCAM, CDH15, CDH3",1.04479346245806,0.45717457304082,FALSE +"HCC95","Input","KEGG_CELL_CYCLE",0.2799,0.82,0.67,2343,0.801,"TGFB2, CDC23, SMAD3, ANAPC4, CDC16, ANAPC7, ANAPC5, RBL1, CDC26, RB1, ORC3, CDC27, MYC, SFN, TFDP2, CDKN1B, CDK7, ANAPC1, ATM, SMC1B, TP53, BUB3, CCNB1, BUB1B, ORC4, MAD1L1, YWHAG, MCM5, MCM4, MCM3, RAD21, RBX1, CUL1, PRKDC, FZR1, SMC3, MCM6",0.173925197299174,0.0963674839157623,FALSE +"HCC95","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.22284,-0.643,0.922,6849,1,"GSK3B, AKT2, GNB1, GSK3A, CXCL14, AKT3, ROCK1, ROCK2, RAP1A, MAPK1, PRKACA, GRK2, CCL13, GNG7, RAP1B, MAPK3, ARRB2, ADCY5, SOS1, AKT1, STAT2, CCL15, TIAM1, CSK, PIK3CB, PRKACB, ARRB1, ADCY6, PRKCB",0.0352690789463706,0,FALSE +"HCC95","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.19649,0.59,0.981,1405,0.973,"IKBKB, TGFB2, SMAD3, KRAS, NRAS, RB1, HRAS, BAD, GAB2, MYC, BCL2L1, CDKN1B",0.0083309926200515,0.0118871597316481,FALSE +"HCC95","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.20983,-0.615,0.925,5925,1,"ACO1, DLD, IDH1, IDH3G, MDH1, CS, SUCLG1, PDHA1, PDHB, SUCLG2, IDH2",0.0338582672609674,0,FALSE +"HCC95","Input","KEGG_COLORECTAL_CANCER",-0.20102,-0.59,0.935,6480,0.983,"CCND1, PIK3R1, BAX, CTNNB1, GSK3B, AKT2, CASP3, APPL1, AKT3, MAPK1, MAPK3, AKT1, TGFB3, PIK3CB, CYCS, SMAD2",0.0291883891274822,0.00744648216786438,FALSE +"HCC95","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.56546,1.68,0.0474,795,0.294,"C9, PLAU, PLAT, F3, C3, VWF, CFH, MBL2",1.32422165832591,0.531652669587843,FALSE +"HCC95","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.29591,-0.864,0.575,7600,0.858,"DNMT1, MTR, LDHA, SRM, SMS, ADI1, AMD1",0.24033215531037,0.0665127121512946,FALSE +"HCC95","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.55509,1.65,0.0553,611,0.302,"EGFR, NGFR, IFNGR1, IL1RAP, CD40, IL1R2, LTBR, ACVR1, TGFB2, IL18, PLEKHO2, CXCL6",1.2572748686953,0.519993057042849,FALSE +"HCC95","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.35365,1.02,0.388,905,0.734,"ZBP1, CASP1, IKBKB, IL18, MAVS",0.411168274405793,0.134303940083929,FALSE +"HCC95","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.3576,-1.06,0.331,7283,0.801,"SGCD, DMD, PRKACA, MYL3, ITGB1, ACTG1, ADCY5, CACNA2D1, TPM3, TGFB3, TPM2, ITGA1, ITGA7, PRKACB, ADCY6, ITGA4, ITGB5, DES, ITGB3",0.480172006224281,0.0963674839157623,FALSE +"HCC95","Input","KEGG_DNA_REPLICATION",0.42673,1.29,0.168,2505,0.573,"RFC2, SSBP1, POLD3, RFC4, RFC5, POLD4, RNASEH2A, POLE, POLD1, RPA3, MCM5, RPA2, MCM4, MCM3, POLE4, POLD2, MCM6, RPA1",0.774690718274137,0.24184537803261,FALSE +"HCC95","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.38939,1.14,0.268,1183,0.64,"EGFR, KRAS, ETV6",0.571865205971211,0.193820026016113,FALSE +"HCC95","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.59062,1.73,0.0385,162,0.29,"ADH4, ADH7, ALDH3A1, GSTM3",1.4145392704915,0.537602002101044,FALSE +"HCC95","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.34528,1.02,0.392,2331,0.734,"CES1, CES2, GMPS, TPMT, IMPDH1, NAT2, NAT1, XDH, IMPDH2, HPRT1, UCKL1, GUSB",0.406713932979543,0.134303940083929,FALSE +"HCC95","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.40015,1.2,0.233,741,0.596,"CD44, SDC1, ITGB4, LAMA1, ITGA2, ITGA6, LAMB3, TNC, ITGA5, ITGA3, LAMC2, VWF, ITGB8, LAMA5, THBS1",0.632644078973981,0.224753740259764,FALSE +"HCC95","Input","KEGG_ENDOCYTOSIS",-0.2701,-0.79,0.699,7143,0.872,"RABEP1, SH3GLB1, DNM1L, ASAP1, CBLB, VPS4A, EHD1, NEDD4L, CHMP2B, GRK2, PLD1, STAM, VPS37A, DNM2, MVB12B, PIP4K2B, RAB5B, SMAP2, ARRB2, SH3GL1, RAB5A, HSPA1L, RAB11B, ASAP2, RAB11FIP5, HSPA2, IQSEC1, PARD6B, ACAP1, DAB2, ERBB3, WWP1, PARD6G, ITCH, ARRB1, DNAJC6, SH3KBP1",0.155522824254319,0.0594835150674328,FALSE +"HCC95","Input","KEGG_ENDOMETRIAL_CANCER",0.27796,0.83,0.661,1596,0.794,"EGFR, KRAS, NRAS, HRAS, BAD, MYC, MLH1, FOXO3, TP53",0.17979854051436,0.100179497572904,FALSE +"HCC95","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.39358,1.16,0.261,1106,0.659,"EGFR, PTPRZ1, JAM3, IKBKB, LYN, ADAM17, JUN, MAPK12, SRC, F11R, MET",0.583359492661719,0.18111458540599,FALSE +"HCC95","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.2687,0.784,0.737,1129,0.821,"NRG1, EGFR, JUN, KRAS, NRAS, NCK1, SRC, HRAS, BAD, MYC",0.132532512140949,0.0856568428805592,FALSE +"HCC95","Input","KEGG_ETHER_LIPID_METABOLISM",-0.4131,-1.21,0.224,7460,0.699,"PLD1, AGPS, PAFAH1B3, PAFAH2, PLA2G12A",0.649751981665837,0.155522824254319,FALSE +"HCC95","Input","KEGG_FATTY_ACID_METABOLISM",0.32621,0.964,0.476,4,0.759,"ADH4, ADH7",0.322393047279507,0.11975822410452,FALSE +"HCC95","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.22993,-0.673,0.882,6376,0.989,"VAV2, MAP2K2, PIK3R1, MAP2K3, MAP2K4, AKT2, AKT3, PRKCE, MAPK14, MAPK1, PRKCA, PLCG1, MAPK3, SOS1, MAP2K7, AKT1, INPP5D, PIK3CB, PLA2G12A, PRKCB",0.0545314148681803,0.0048037084028206,FALSE +"HCC95","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.45128,-1.31,0.156,7113,0.562,"ARPC3, AKT3, DNM1L, PRKCE, ASAP1, MAPK1, PRKCA, PLD1, WASF2, DNM2, PIP4K2B, PLCG1, MAPK3, GSN, AKT1, MARCKS, PRKCG, VASP, INPP5D, ASAP2, PIK3CB, SCIN, PRKCB, SPHK2, CFL2, PTPRC, AMPH, MARCKSL1",0.806875401645538,0.250263684430939,FALSE +"HCC95","Input","KEGG_FOCAL_ADHESION",0.30851,0.945,0.48,823,0.769,"EGFR, CAV1, CAV2, ITGB4, LAMA1, ITGA2, ITGA6, LAMB3, VAV1, TNC, ITGA5, ITGA3, IGF1R, LAMC2, RAC2, VWF, JUN, ITGB8, LAMA5, RAC3, THBS1, SRC",0.318758762624413,0.114073660198569,FALSE +"HCC95","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.6915,-2.02,0.00568,6964,0.206,"GGH, PTS, ALPI, ALPP, ALPL",2.24565166428898,0.686132779630847,TRUE +"HCC95","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.31105,0.909,0.521,267,0.802,"AKR1B10, ALDOC, AKR1B1",0.283162276700476,0.0958256317158365,FALSE +"HCC95","Input","KEGG_GALACTOSE_METABOLISM",-0.3265,-0.954,0.465,6547,0.857,"HK2, GALE, GLB1, UGP2, GALK1, PFKL, GALK2, PFKP, GALT, GCK, PGM1",0.332547047110046,0.0670191780768018,FALSE +"HCC95","Input","KEGG_GAP_JUNCTION",0.24179,0.716,0.825,1246,0.891,"EGFR, GJA1, KRAS, NRAS, SRC, PLCB4, ADCY3, ADCY8, HRAS, MAP3K2, TUBA4A",0.0835460514500749,0.0501222959631252,FALSE +"HCC95","Input","KEGG_GLIOMA",-0.26594,-0.782,0.703,7341,0.876,"MAPK1, PRKCA, PLCG1, MAPK3, SOS1, AKT1, PRKCG, CDK6, PIK3CB, CALM2, PRKCB, CDKN2A",0.153044674980176,0.0574958938319193,FALSE +"HCC95","Input","KEGG_GLUTATHIONE_METABOLISM",0.34949,1.01,0.383,897,0.724,"GCLC, GCLM, GSTM3, ODC1, PGD, GPX2, GSS, GSTP1, GSR, G6PD",0.416801226031377,0.140261433802853,FALSE +"HCC95","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.54756,-1.64,0.0487,8387,0.252,"CEL, GK, ALDH9A1, ALDH7A1, MGLL",1.31247103878537,0.598599459218456,FALSE +"HCC95","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33046,0.964,0.454,1358,0.759,"LPCAT3, PCYT1B, PCYT1A, PLPP1, DGKA, LCLAT1, DGKZ, LPCAT2, CDIPT, PISD",0.342944147142896,0.11975822410452,FALSE +"HCC95","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.40043,1.2,0.247,1202,0.596,"PIPOX, GATM, PHGDH, PSAT1, MAOA, PSPH",0.607303046740334,0.224753740259764,FALSE +"HCC95","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.36729,1.08,0.339,175,0.675,"ADH4, ADH7, ALDH3A1, ALDOC",0.469800301796918,0.170696227168975,FALSE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.41301,1.21,0.231,1065,0.639,"XYLT2, CHST14, B4GALT7",0.636388020107856,0.1944991418416,FALSE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.57653,1.74,0.0273,1478,0.31,"HS6ST2, XYLT2, B4GALT7, EXTL2",1.56383735295924,0.508638306165727,FALSE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.55906,-1.64,0.0592,6606,0.252,"FUT8, B4GALT3, B4GAT1, B4GALT4, ST3GAL2",1.22767829327708,0.598599459218456,FALSE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.27533,0.801,0.684,3109,0.813,"IDS, HPSE, HEXB, ARSB, GUSB, SGSH, HEXA",0.164943898279884,0.0899094544059319,FALSE +"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.26283,-0.779,0.755,8275,0.87,"ST3GAL2",0.122053048370812,0.0604807473813815,FALSE +"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.41618,1.23,0.195,1786,0.622,"GLA, FUT1, HEXB",0.709965388637482,0.206209615309181,FALSE +"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.59234,-1.7,0.0471,8249,0.257,"B4GALT4, GCNT2, ST3GAL6, ST3GAL4, B3GNT3",1.3269790928711,0.590066876668705,FALSE +"HCC95","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.29889,0.864,0.559,6214,0.801,"PIGB, PIGS, PIGX, PGAP1, PIGU, PIGT, PIGO, PIGG, GPAA1, PIGK, PIGW, PIGA",0.252588192113577,0.0963674839157623,FALSE +"HCC95","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.55036,-1.66,0.0375,6527,0.28,"MDH1, CS, PGP, HYI",1.42596873227228,0.552841968657781,FALSE +"HCC95","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.27382,0.816,0.719,1177,0.797,"EGFR, MMP14, JUN, MAPK12, KRAS, NRAS, SRC, PLCB4, ADCY3, ADCY8, ATF4, HRAS, MAP3K2, CALML3",0.143271109617117,0.0985416786038876,FALSE +"HCC95","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.29688,-0.861,0.601,6745,0.85,"WNT11, GSK3B, PRKACA, CSNK1G2, SHH, CSNK1D, PRKACB",0.22112552799726,0.0705810742857073,FALSE +"HCC95","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.52269,1.54,0.0737,442,0.368,"CD44, ITGA2, ITGA6, IL1R2, ITGA5, ITGA3, CD9",1.13253251214095,0.434152181326482,FALSE +"HCC95","Input","KEGG_HISTIDINE_METABOLISM",-0.34838,-1.04,0.356,8524,0.792,"ALDH9A1, ALDH7A1",0.448550002027125,0.101274818410506,FALSE +"HCC95","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.62976,1.86,0.0275,2505,0.237,"TOP3B, RAD54L, SSBP1, POLD3, BLM, POLD4, POLD1, RPA3, RPA2, MUS81, RAD51, POLD2, RPA1",1.56066730616974,0.625251653989896,TRUE +"HCC95","Input","KEGG_HUNTINGTONS_DISEASE",-0.21332,-0.627,0.935,5918,1,"NDUFB1, AP2A2, SLC25A31, NDUFA8, DCTN4, NDUFB8, DCTN1, COX5B, NDUFS7, CLTB, CREB5, CLTA, COX7A2, COX4I1, NDUFS2, UQCRQ, HTT, POLR2H, DCTN2, NDUFA3, BAX, SLC25A6, NDUFAB1, CASP3, TBP, GPX1, COX5A, NDUFB4, HDAC2, NDUFB7, COX6C, NDUFA2, COX7C, SLC25A4, CYCS, COX7B, TGM2, ATP5MC2",0.0291883891274822,0,FALSE +"HCC95","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.34948,-1.04,0.374,7768,0.792,"ITGB1, ACTG1, CACNA2D1, TPM3, TGFB3, TPM2, ITGA1, ITGA7, ITGA4, ITGB5, DES, ITGB3, ACE",0.42712839779952,0.101274818410506,FALSE +"HCC95","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.42159,-1.24,0.207,6918,0.657,"PIP4K2C, PI4KA, INPP1, OCRL, INPPL1, PIP4K2A, PIP4K2B, PLCG1, PIK3C2B, ITPKB, SYNJ1, INPP4B, PIK3CB, PI4KB",0.684029654543082,0.182434630440219,FALSE +"HCC95","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.18628,-0.547,0.974,6195,0.982,"PYGB, MAP2K1, RPS6KB1, EIF4E, RPS6, MAP2K2, PRKAR1A, PIK3R1, HK2, RHEB, PPP1R3D, TRIP10, GSK3B, AKT2, AKT3, FBP1, CBLB, MAPK1, PRKACA, GYS1, PRKAR2B, MAPK3, SOS1, AKT1, INPP5D, SORBS1, PIK3CB, CALM2, PDE3A, GCK, PRKACB",0.0114410431213845,0.00788851221305034,FALSE +"HCC95","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.26382,-0.762,0.752,6243,0.879,"STAT1, OSM, PTPN11, EPO, CCND1, PIK3R1, STAT5B, PIM1, STAM2, SPRY2, AKT2, IL13RA2, AKT3, CBLB, STAM, SOS1, AKT1, STAT2, PIK3CB, SPRY1, SPRY4",0.123782159408358,0.0560111249262281,FALSE +"HCC95","Input","KEGG_LEISHMANIA_INFECTION",-0.33228,-0.992,0.435,7269,0.819,"MAPK14, IRAK4, MAPK1, ITGB2, MAPK3, ITGB1, MYD88, TGFB3, PRKCB, ITGA4, CYBA, MARCKSL1",0.361510743045363,0.0867160982395816,FALSE +"HCC95","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.3173,0.938,0.479,966,0.769,"THY1, CLDN11, JAM3, CLDN6, CLDN1, VAV1, RAC2, MAPK12, CTNND1, F11R, OCLN",0.319664486585437,0.114073660198569,FALSE +"HCC95","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.74901,-2.25,0,8438,0.21,"YOD1, ALDH9A1, ALDH7A1",Inf,0.677780705266081,TRUE +"HCC95","Input","KEGG_LONG_TERM_DEPRESSION",-0.28569,-0.831,0.647,7341,0.838,"MAPK1, PRKCA, PRKG1, MAPK3, PPP2CB, PRKCG, PLA2G12A, PRKCB, CACNA1A",0.1890957193313,0.0767559813697235,FALSE +"HCC95","Input","KEGG_LONG_TERM_POTENTIATION",-0.31122,-0.911,0.543,7247,0.849,"RAP1A, PPP3CC, MAPK1, PRKACA, PRKCA, RAP1B, MAPK3, PRKCG, CALM2, PPP3R1, RPS6KA3, PPP3R2, PRKACB, PRKCB",0.265200170411153,0.0710923097560473,FALSE +"HCC95","Input","KEGG_LYSINE_DEGRADATION",-0.35242,-1.03,0.376,7895,0.78,"ACAT1, DOT1L, GCDH, ALDH9A1, ALDH7A1",0.424812155072339,0.10790539730952,FALSE +"HCC95","Input","KEGG_LYSOSOME",-0.33836,-0.994,0.44,6094,0.831,"GGA2, SLC11A2, AP1G1, NAGPA, PLA2G15, AP3M1, PSAPL1, AP3M2, CLTB, CLTA, ARSA, ATP6AP1, FUCA1, GLB1, AP1B1, SMPD1, DNASE2, CTSC, CTSF, CLN3, AP3S1, ACP5, AP1M2, ATP6V0A2, LGMN, GGA3, AP3D1, AGA, ATP6V1H, ATP6V0A1, TCIRG1, CTSK, CTSO, AP3S2, PPT2, IGF2R, SCARB2, NAPSA, GNS, GGA1, ASAH1, MANBA, ATP6V0D1, LIPA, AP1S2, SORT1, CD63, SLC17A5, MCOLN1",0.356547323513813,0.080398976215889,FALSE +"HCC95","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.21082,-0.606,0.93,7247,0.994,"RAP1A, PPP3CC, MAPK14, MAPK1, PRKACA, PRKCA, PPP5C, CD14, RAP1B, MAPK3, ARRB2, CACNA2D1, SOS1, MAP2K7, AKT1, PRKCG, RASA2, MOS, HSPA1L, MAPKAPK2, TGFB3, MAP3K5, HSPA2, PPP3R1, MAP4K4, RPS6KA3, PPP3R2, PLA2G12A, STMN1, PRKACB, ARRB1, PRKCB, NFATC2, CACNA1A",0.0315170514460649,0.00261361560268669,FALSE +"HCC95","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.60038,-1.73,0.0307,8205,0.266,"FOXA2, GCK, HNF1A, HNF4A",1.51286162452281,0.575118363368933,FALSE +"HCC95","Input","KEGG_MELANOGENESIS",-0.29709,-0.88,0.583,7341,0.848,"MAPK1, PRKACA, PRKCA, MAPK3, ADCY5, PRKCG, TYR, CALM2, PRKACB, TYRP1, DCT, ADCY6, PRKCB, MITF",0.234331445240986,0.0716041477432862,FALSE +"HCC95","Input","KEGG_MELANOMA",0.34645,1.02,0.39,1106,0.734,"EGFR, IGF1R, FGF13, FGF2, KRAS, NRAS, RB1, HRAS, BAD, MET",0.408935392973501,0.134303940083929,FALSE +"HCC95","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.73845,2.22,0.00226,162,0.104,"ADH4, ADH7, AKR1C2, AKR1C1, AKR1C3, CYP2S1, ALDH3A1, GSTM3",2.6458915608526,0.98296666070122,TRUE +"HCC95","Input","KEGG_MISMATCH_REPAIR",0.64059,1.86,0.0267,2505,0.237,"MSH3, RFC2, SSBP1, POLD3, MLH1, RFC4, RFC5, POLD4, MSH2, PMS2, POLD1, RPA3, RPA2, POLD2, MSH6, RPA1",1.57348873863542,0.625251653989896,TRUE +"HCC95","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.44542,-1.34,0.124,6130,0.552,"RPS6KA2, RPS6KB1, EIF4E, RPS6, PIK3R1, RHEB, RPS6KA6, AKT2, AKT3, MAPK1, MAPK3, AKT1, PIK3CB, RPS6KA3, ULK3",0.906578314837765,0.258060922270801,FALSE +"HCC95","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.29347,0.87,0.605,873,0.815,"IFNGR1, MICA, VAV1, RAET1L, ULBP2, PTPN6, RAC2, KRAS, NRAS, RAC3, LAT, TNFRSF10A",0.218244625347531,0.0888423912600234,FALSE +"HCC95","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.40838,1.2,0.218,2491,0.596,"GRIN1, NR3C1, PRSS3, F2RL1, HRH1, P2RX4, LTB4R2, CGA, CTSG, F2",0.661543506395395,0.224753740259764,FALSE +"HCC95","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.20035,-0.598,0.952,6414,0.989,"PTPN11, MAP2K2, PIK3R1, FRS2, RPS6KA6, CAMK2D, BAX, NFKBIB, YWHAQ, GSK3B, AKT2, AKT3, RIPK2, ARHGDIA, RAP1A, MAPK14, IRAK4, ARHGDIB, MAPK1, PLCG1, RAP1B, MAPK3, SOS1, MAP2K7, AKT1, CSK, MAPKAPK2, MAP3K5, PIK3CB, CALM2, RPS6KA3, SORT1, MAGED1, PSEN1",0.0213630516155257,0.0048037084028206,FALSE +"HCC95","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.62232,-1.86,0.022,8340,0.253,"ENPP1, NT5E, NNMT, NNT, QPRT, BST1",1.65757731917779,0.596879478824182,FALSE +"HCC95","Input","KEGG_NITROGEN_METABOLISM",-0.67522,-1.98,0.0121,7877,0.197,"CPS1, CA2, GLS, GLS2, CA14, CA8, GLUD2",1.91721462968355,0.705533773838407,TRUE +"HCC95","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.38109,1.1,0.319,684,0.705,"TRAF6, CASP1, IKBKB, IL18, TRIP6, MAPK12",0.496209316942819,0.151810883008601,FALSE +"HCC95","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.50282,1.48,0.0783,3006,0.349,"XRCC4, POLM, PRKDC, XRCC5, LIG4, FEN1",1.10623823794206,0.45717457304082,FALSE +"HCC95","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.31675,-0.91,0.532,7718,0.837,"PLCG1, MAPK3, SOS1, AKT1, PRKCG, CDK6, PIK3CB, PRKCB, CDKN2A, RASSF5, FHIT",0.274088367704952,0.07727454200674,FALSE +"HCC95","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.2818,-0.838,0.642,6983,0.86,"APH1A, NCSTN, LFNG, HDAC2, CIR1, DTX3L, NOTCH2, CTBP2, PSEN2, PSEN1",0.192464971931147,0.0655015487564323,FALSE +"HCC95","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.58293,1.72,0.0358,2715,0.275,"XPA, DDB2, ERCC5, ERCC8, RAD23B, RFC2, POLD3, RFC4, CUL4A, RFC5, ERCC1, CDK7, GTF2H1, MNAT1, POLD4, POLE, GTF2H4, ERCC4, ERCC3, POLD1, RPA3, GTF2H3, RPA2, GTF2H5, DDB1, POLE4, RBX1, POLD2, XPC, CCNH, RPA1, ERCC2, GTF2H2",1.44611697335613,0.560667306169737,FALSE +"HCC95","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.29047,0.871,0.606,1414,0.827,"ALG13, ALG12, ST6GAL1, MAN2A1, ALG2, MGAT1, MGAT4B, B4GALT1, MAN1A1",0.217527375833714,0.0824944904474534,FALSE +"HCC95","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.58963,-1.73,0.0344,7045,0.266,"PDC, PRKACA, PRKG1, ARRB2, CALM2, PRKACB, PDE1C",1.46344155742847,0.575118363368933,FALSE +"HCC95","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.38196,-1.12,0.275,6210,0.706,"ATIC, MTHFS, GART, MTHFR, MTR, TYMS",0.560667306169737,0.151195298948196,FALSE +"HCC95","Input","KEGG_OOCYTE_MEIOSIS",-0.19859,-0.582,0.958,6621,0.977,"CCNB2, PPP2R5B, RPS6KA6, CAMK2D, YWHAQ, MAD2L1, PPP2R5A, PLK1, PPP3CC, MAPK1, PRKACA, MAPK3, PPP2CB, ADCY5, MOS, SGO1, CALM2, PPP3R1, CDK2, RPS6KA3, PPP3R2, PRKACB, ADCY6",0.0186344909214556,0.0101054362812269,FALSE +"HCC95","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.20024,-0.613,0.953,6439,0.999,"FUCA1, GLB1, FUCA2, AGA, MANBA",0.0209070993616736,0.000434511774017692,FALSE +"HCC95","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.43404,-1.27,0.167,6417,0.619,"COX7A2, ATP6AP1, COX4I1, NDUFS2, UQCRQ, NDUFA3, NDUFAB1, ATP6V1B1, PPA1, COX5A, ATP6V0A2, NDUFB4, ATP6V1F, ATP6V1H, PPA2, NDUFB7, ATP6V1B2, ATP6V1A, ATP6V1C2, COX6C, ATP6V0A1, TCIRG1, NDUFA2, ATP6V1C1, ATP6V1D, ATP6V1E1, COX7C, ATP6V1G1, ATP6V0D1, COX7B, ATP5MC2, COX17",0.777283528852417,0.208309350979882,FALSE +"HCC95","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.46048,-1.32,0.14,7735,0.566,"GALNT6, B4GALT5, ST3GAL2, C1GALT1C1, C1GALT1, GALNT16, GALNT17",0.853871964321762,0.247183568811729,FALSE +"HCC95","Input","KEGG_P53_SIGNALING_PATHWAY",-0.31951,-0.941,0.484,7931,0.84,"CD82, RCHY1, CDK6, CYCS, CDK2, COP1, RRM2, CDKN2A, TP53I3",0.315154638355588,0.0757207139381184,FALSE +"HCC95","Input","KEGG_PANCREATIC_CANCER",0.24554,0.748,0.789,1105,0.851,"EGFR, IKBKB, TGFB2, RAC2, SMAD3, KRAS, RAC3, RB1, BAD",0.10292299679058,0.0700704399154121,FALSE +"HCC95","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.42371,1.25,0.186,320,0.605,"BCAT2, BCAT1",0.730487055782084,0.218244625347531,FALSE +"HCC95","Input","KEGG_PARKINSONS_DISEASE",-0.2927,-0.881,0.581,6229,0.86,"COX5B, NDUFS7, PARK7, COX7A2, COX4I1, NDUFS2, UQCRQ, NDUFA3, SLC25A6, UBE2G2, NDUFAB1, UBE2G1, UBE2L6, UBE2L3, CASP3, COX5A, NDUFB4, NDUFB7, COX6C, NDUFA2, UBA1, COX7C, UBE2J1, SLC25A4, CYCS, COX7B, SLC18A1, ATP5MC2",0.235823867609669,0.0655015487564323,FALSE +"HCC95","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.34548,-0.988,0.411,5571,0.812,"EZR, NCK2, FYN, ARPC4, TUBB1, ACTB, WASL, TUBA1B, ARPC5, TUBB3, NCL, TUBA1C, TUBB, TUBB2A, CTNNB1, YWHAQ, TUBA3C, ARPC3, ROCK1, ROCK2, ARHGEF2, TUBB6, PRKCA, HCLS1, CD14, ITGB1, ACTG1, TUBB2B",0.386158178123931,0.0904439707588247,FALSE +"HCC95","Input","KEGG_PATHWAYS_IN_CANCER",0.29121,0.864,0.613,1460,0.801,"EGFR, SLC2A1, FZD1, TRAF6, LAMA1, WNT5A, RXRA, ITGA2, ITGA6, AR, LAMB3, PML, IKBKB, ITGA3, IGF1R, FZD6, LAMC2, TGFB2, RAC2, JUN, GSTP1, FGF13, FGF2, SMAD3, LAMA5, KRAS, NRAS, RAC3, RB1, RARA, HRAS, MSH3, BAD, MET, PTGS2, MYC, MLH1, FZD2, BCL2L1, DVL3, CDKN1B, FH, STAT3",0.212539525481585,0.0963674839157623,FALSE +"HCC95","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.30188,0.898,0.563,771,0.812,"AKR1B1, UGDH",0.249491605148654,0.0904439707588247,FALSE +"HCC95","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.26871,-0.796,0.713,7036,0.872,"RPE, FBP1, PFKL, DERA, PFKP, RBKS, RPIA, PGM1",0.146910470148134,0.0594835150674328,FALSE +"HCC95","Input","KEGG_PEROXISOME",-0.38494,-1.14,0.259,7196,0.681,"PEX26, PEX11A, ECI2, AMACR, ABCD4, PEX16, AGPS, ABCD3, HSD17B4, ACSL6, PEX6, SCP2, PEX12, PEX1, ABCD1, DECR2, PECR, IDH2, PEX19, ACOX3, ACOT8, ACAA1, ACSL1, HACL1, ACSL5, FAR2",0.586700235918748,0.166852888087215,FALSE +"HCC95","Input","KEGG_PHENYLALANINE_METABOLISM",0.64089,1.94,0.0149,1060,0.223,"ALDH3A1, GOT2, MAOA",1.82681373158773,0.651695136951839,TRUE +"HCC95","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.41044,-1.19,0.239,6918,0.696,"PIP4K2C, PI4KA, INPP1, PRKCA, OCRL, INPPL1, PIP4K2A, PIP4K2B, PLCG1, PIK3C2B, ITPKB, PRKCG, SYNJ1, INPP4B, INPP5D, PIK3CB, CALM2, PI4KB, PRKCB",0.621602099051862,0.157390760389438,FALSE +"HCC95","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.3439,-1.03,0.378,7114,0.78,"EARS2, UROD, CPOX, PPOX, HMOX1, HCCS, UROS",0.422508200162775,0.10790539730952,FALSE +"HCC95","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.37255,-1.09,0.309,7286,0.751,"ACADM, GK2, SLC27A4, FABP6, FABP5, ILK, DBI, ACSL6, FABP3, SCP2, SORBS1, FABP4, ACOX3, GK, ACAA1, ACSL1, CYP27A1, ACSL5",0.510041520575165,0.124360062995832,FALSE +"HCC95","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.46461,1.35,0.134,37,0.515,"AKR1D1",0.872895201635192,0.288192770958809,FALSE +"HCC95","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.31845,0.95,0.511,1341,0.773,"CD40, TAP1, TAP2",0.291579099865287,0.111820506081675,FALSE +"HCC95","Input","KEGG_PRION_DISEASES",0.33232,0.977,0.441,563,0.762,"C9, PRNP",0.355561410532161,0.1180450286604,FALSE +"HCC95","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.21599,-0.635,0.934,6530,1,"PIK3R1, CCNB2, RPS6KA6, AKT2, MAD2L1, PLK1, AKT3, MAPK14, MAPK1, PRKACA, MAPK3, ADCY5, AKT1, MOS, PIK3CB, CDK2, PDE3A, RPS6KA3, PRKACB, ADCY6",0.0296531237699066,0,FALSE +"HCC95","Input","KEGG_PROPANOATE_METABOLISM",-0.46237,-1.38,0.12,7870,0.5,"LDHA, ACAT1, SUCLG2, ACSS3, ALDH9A1, ALDH7A1",0.920818753952375,0.301029995663981,FALSE +"HCC95","Input","KEGG_PROSTATE_CANCER",0.37258,1.09,0.301,1105,0.689,"EGFR, AR, IKBKB, IGF1R, GSTP1, KRAS, NRAS, RB1, ATF4, HRAS, BAD",0.521433504406157,0.161780778092374,FALSE +"HCC95","Input","KEGG_PROTEASOME",0.52184,1.58,0.058,3172,0.341,"PSMB9, PSMB8, PSMB10, PSME1, PSMB4, PSME2, PSME4, POMP, PSMB3, PSMB7, PSMA4, PSME3, PSMA8, PSMC2, PSMA2, PSMF1, PSMB2, PSMA6, PSMB5, PSMA1, PSMD12, PSMD4, PSMC4, PSMA7, PSMB1, PSMC3, PSMC5, PSMC1",1.23657200643706,0.467245621007502,FALSE +"HCC95","Input","KEGG_PROTEIN_EXPORT",-0.28253,-0.836,0.672,7078,0.852,"SPCS2, SEC11A, IMMP1L, SEC11C",0.172630726946175,0.0695604052332999,FALSE +"HCC95","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.39349,-1.14,0.259,7991,0.681,"CA2, GLS, GLS2, GLUD2",0.586700235918748,0.166852888087215,FALSE +"HCC95","Input","KEGG_PURINE_METABOLISM",-0.36054,-1.05,0.35,7213,0.806,"AK2, AMPD2, APRT, NPR1, POLA2, GDA, PDE4D, POLA1, ADCY5, GMPR, PRUNE1, AK1, ENPP1, PDE3A, NPR2, PAPSS2, RRM2, NT5E, ADCY6, NME4, FHIT, PDE4A, PDE1C",0.455931955649724,0.0936649581949093,FALSE +"HCC95","Input","KEGG_PYRIMIDINE_METABOLISM",-0.27985,-0.832,0.645,7477,0.848,"POLA2, TYMP, CMPK1, CTPS1, UMPS, POLA1, TYMS, CTPS2, RRM2, NT5E, NME4, TK1, TK2",0.190440285364732,0.0716041477432862,FALSE +"HCC95","Input","KEGG_PYRUVATE_METABOLISM",-0.40539,-1.2,0.227,7239,0.697,"PDHA1, ACYP2, PDHB, HAGH, LDHA, ACAT1, ME3, ACYP1, ALDH9A1, ALDH7A1",0.643974142806877,0.156767221901991,FALSE +"HCC95","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.23428,0.678,0.865,733,0.911,"EGFR, ITGB4, PFN2, ITGA2, IQGAP2, ITGA6, VAV1, ITGA5, ITGA3, RAC2, GNA13, ITGB8, FGF13, FGF2, KRAS, NRAS, RAC3",0.0629838925351858,0.0404816230270017,FALSE +"HCC95","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.62807,-1.83,0.0293,6893,0.225,"ATG4C, ATG4A, GABARAPL1, ATG4B, ATG3, ULK3, GABARAPL2",1.53313237964589,0.647817481888638,TRUE +"HCC95","Input","KEGG_RENAL_CELL_CARCINOMA",0.20618,0.61,0.942,1106,0.971,"SLC2A1, TGFB2, JUN, KRAS, NRAS, HRAS, MET",0.0259490972071227,0.0127807700919951,FALSE +"HCC95","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.55799,-1.64,0.0443,7272,0.252,"MME, ANPEP, CPA3, ACE",1.35359627377693,0.598599459218456,FALSE +"HCC95","Input","KEGG_RETINOL_METABOLISM",0.71108,2.17,0.00407,314,0.101,"ADH4, ADH7, DHRS3",2.39040559077478,0.995678626217357,TRUE +"HCC95","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.65588,-1.93,0.00938,6852,0.209,"ACP1, ACP5, PHPT1, TYR, MTMR6, ENPP1",2.02779716162094,0.679853713888946,TRUE +"HCC95","Input","KEGG_RIBOSOME",0.2264,0.69,0.883,3922,0.906,"RPL22L1, RPL37, RPL29, RPL26L1, RPL32, RPL4, RPS27A, RPL37A, RPL14, RPL27, RPL24, RSL24D1, RPSA, RPL34, RPS12, RPS16, RPL36A, RPL36AL, RPL35A, RPL27A, RPL7A, RPL35, RPL13A, RPS3A, RPL10A, FAU, RPS8, RPS11, RPS15A, UBA52, RPS3, RPL21, RPL19, RPL36, RPL23, RPL23A, RPLP0, RPS26, RPL30",0.0540392964224314,0.0428718023231869,FALSE +"HCC95","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.27389,-0.802,0.694,5873,0.872,"ATG12, MAPK8, TKFC, TBK1, FADD, MAP3K7, PIN1, DHX58, NFKBIB, IRF3, CYLD, OTUD5, MAPK14, TRAF3, DDX58, ISG15, RIPK1, DDX3Y",0.158640529545145,0.0594835150674328,FALSE +"HCC95","Input","KEGG_RNA_DEGRADATION",0.2515,0.749,0.77,3336,0.861,"PAPOLG, EXOSC1, LSM4, DIS3, EXOSC3, EXOSC8, EXOSC6, EXOSC9, PARN, EXOSC4, LSM6, EXOSC5, C1D, HSPA9, SKIV2L, PNPT1, CNOT6, XRN2, EXOSC2, LSM3, MTREX, EDC3, EXOSC7, LSM8, XRN1, ZCCHC7, LSM7, LSM2, TTC37",0.113509274827518,0.0649968485463452,FALSE +"HCC95","Input","KEGG_RNA_POLYMERASE",0.24366,0.705,0.853,6706,0.896,"POLR3G, POLR1E, POLR1B, POLR1A, POLR2G, POLR2K, POLR1C, POLR1D, POLR2J, POLR2L, POLR2E, POLR2I, POLR2A, POLR2D, POLR2C, POLR3C, POLR2B, POLR2F, POLR3H, POLR3F, POLR3K, POLR3A, POLR3D, POLR2H, POLR3B, POLR3GL",0.069050968832477,0.0476919903378748,FALSE +"HCC95","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.25909,0.765,0.738,1348,0.844,"BUD23, SCLY, MAT1A, METTL2B, MAT2B",0.131943638176958,0.073657553374345,FALSE +"HCC95","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.30067,0.889,0.557,431,0.817,"TRAF6, LAMA1, RXRA, ITGA2, ITGA6, LAMB3, IKBKB, ITGA3, LAMC2",0.254144804826271,0.0877779434675845,FALSE +"HCC95","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.48851,-1.43,0.1,6947,0.461,"STX18, STX6, VTI1B, VTI1A, SNAP47, SEC22B, SNAP29, VAMP7, VAMP4, STX12, YKT6, STX7, STX3",1,0.336299074610352,FALSE +"HCC95","Input","KEGG_SPHINGOLIPID_METABOLISM",0.33855,0.99,0.406,1337,0.75,"PLPP1, KDSR, GLA, GALC, NEU3, SGPL1, UGT8",0.391473966422806,0.1249387366083,FALSE +"HCC95","Input","KEGG_SPLICEOSOME",0.27153,0.784,0.714,3431,0.821,"DHX8, NCBP1, DHX38, CRNKL1, SLU7, LSM4, DDX42, EFTUD2, SNU13, HSPA1A, TXNL4A, LSM6, PRPF6, PRPF38A, PRPF19, AQR, SNRPB, HSPA6, PPIE, ZMAT2, BCAS2, PPIL1, DDX46, PRPF18, THOC3, ISY1, CCDC12, SF3A2, SNRPD3, EIF4A3, SNRPF, NCBP2, SNRNP200, LSM3, PRPF8, TCERG1, HNRNPK, SF3B5, PLRG1, DDX39B, USP39, SNRPG, SNRPD1, SNRPD2, PRPF40B, LSM8, SF3B6, SF3A1, SNW1, HNRNPA3, ALYREF, SNRNP70, DDX23, SMNDC1, THOC2, LSM7, LSM2, CDC5L, SF3B1, TRA2B, SF3A3, DDX5, SNRNP40, HNRNPC, SNRPC",0.146301788223826,0.0856568428805592,FALSE +"HCC95","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.29046,-0.858,0.591,7465,0.844,"GYS1, GBE1, ENPP1, GCK, PGM1",0.228412519118745,0.073657553374345,FALSE +"HCC95","Input","KEGG_STEROID_BIOSYNTHESIS",-0.38885,-1.15,0.266,7136,0.719,"HSD17B7, CYP51A1, SOAT1, TM7SF2, CEL, LIPA",0.575118363368933,0.143271109617117,FALSE +"HCC95","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.79115,2.35,0,37,0.0912,"AKR1C2, AKR1C1, AKR1C3, AKR1D1",Inf,1.04000516167158,TRUE +"HCC95","Input","KEGG_SULFUR_METABOLISM",-0.75757,-2.22,0.00712,8250,0.133,"CHST11, PAPSS2, SULT1A3, SULT1A1",2.14752000636314,0.876148359032914,TRUE +"HCC95","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.68017,2,0.013,224,0.209,"C9, C3, CD40",1.88605664769316,0.679853713888946,TRUE +"HCC95","Input","KEGG_TASTE_TRANSDUCTION",-0.6437,-1.85,0.0314,8551,0.233,"PRKACB, ADCY6, CACNA1A",1.50307035192679,0.632644078973981,TRUE +"HCC95","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.54274,-1.59,0.062,7115,0.275,"IDI1, HMGCR, MVD, FDPS, ACAT1",1.20760831050175,0.560667306169737,FALSE +"HCC95","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.30931,-0.885,0.549,7152,0.866,"ROCK1, ROCK2, SMAD5, MAPK1, MAPK3, PPP2CB, TGFB3, ZFYVE9, INHBE, SMAD2",0.260427655549908,0.0624821079826534,FALSE +"HCC95","Input","KEGG_THYROID_CANCER",0.28918,0.855,0.582,1129,0.781,"RXRA, KRAS, NRAS, HRAS, MYC",0.235077015350112,0.1073489661227,FALSE +"HCC95","Input","KEGG_TIGHT_JUNCTION",0.28629,0.861,0.628,1088,0.794,"CLDN11, JAM3, MYH4, CLDN6, CLDN1, YES1, EPB41L1, YBX3, KRAS, NRAS, PATJ, SRC, F11R, OCLN, HRAS, ACTN4",0.202040356262804,0.100179497572904,FALSE +"HCC95","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.29647,-0.847,0.614,6156,0.855,"TLR9, MAP2K1, STAT1, TBK1, FADD, MAP3K7, MAP2K2, PIK3R1, MAP2K3, MAP2K4, AKT2, IRF3, AKT3, MAPK14, IRAK4, MAPK1, TRAF3, TOLLIP, CD14, CTSK, MAPK3, MAP2K7, AKT1, MYD88, PIK3CB, RIPK1",0.211831628858832,0.0680338852718274,FALSE +"HCC95","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.38548,-1.14,0.266,7805,0.681,"KMO, ACAT1, GCDH, ALDH9A1, ALDH7A1",0.575118363368933,0.166852888087215,FALSE +"HCC95","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.28783,0.854,0.618,498,0.771,"PDX1, ABCC8, IKBKB, IRS1",0.209011524911184,0.112945621949043,FALSE +"HCC95","Input","KEGG_TYROSINE_METABOLISM",0.54225,1.61,0.0533,1060,0.326,"ADH4, ADH7, ALDH3A1, BUD23, GOT2, METTL2B, MAOA",1.27327279097343,0.486782399932061,FALSE +"HCC95","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.26284,-0.769,0.754,6772,0.877,"NFKBIB, GSK3B, AKT2, NFAT5, AKT3, PPP3CC, MAPK14, CBLB, MAPK1, PLCG1, MAPK3, SOS1, MAP2K7, AKT1, PIK3CB, PPP3R1, PPP3R2, NFATC2, PTPRC, GRAP2",0.122628654130226,0.0570004066339595,FALSE +"HCC95","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.18932,0.553,0.984,1462,0.98,"TRAF6, PML, UBE2H, DDB2, CDC23, ANAPC4, CDC16, ANAPC7, FBXO4, NEDD4, ANAPC5, CDC26, ERCC8, CDC27, CUL4A, UBE2Z, FBXO2, UBE3C, FBXW11, ANAPC1",0.00700490156865849,0.00877392430750515,FALSE +"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.61955,1.81,0.0213,320,0.26,"BCAT2, BCAT1",1.67162039656126,0.585026652029182,FALSE +"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.31255,-0.919,0.501,7895,0.86,"ACAT1, ACAA2, HSD17B10, ALDH9A1, ACAA1, ALDH7A1",0.300162274132754,0.0655015487564323,FALSE +"HCC95","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.48012,-1.41,0.102,7096,0.472,"ARHGEF1, ROCK1, ROCK2, PRKCE, MAPK1, PRKACA, PRKCA, NPR1, PRKG1, MAPK3, ADCY5, PRKCG, PPP1R12B, ARHGEF11, KCNMA1, MYLK, CALM2, CALD1, NPR2, PLA2G12A, PRKACB, ADCY6, PRKCB",0.991399828238082,0.326058001365912,FALSE +"HCC95","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.40177,-1.18,0.242,5979,0.695,"RAB5C, DCTN4, DCTN1, NSF, CREB5, RAB11A, DCTN2, ARHGDIA, ARHGDIB, PRKACA, RAB5B, DYNC1LI1, RAB5A, RAB11B, PRKACB, ADCY6",0.616184634019569,0.158015195409886,FALSE +"HCC95","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.32187,-0.947,0.485,6854,0.857,"AKT2, NFAT5, MAPKAPK3, AKT3, PPP3CC, MAPK14, MAPK1, PRKCA, PLCG1, MAPK3, AKT1, PRKCG, MAPKAPK2, PIK3CB, PPP3R1, PPP3R2, PLA2G12A, PRKCB, NFATC2, SPHK2",0.314258261397736,0.0670191780768018,FALSE +"HCC95","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.58265,-1.72,0.028,7120,0.255,"ATP6V0A2, ATP6V1F, ATP6V1H, PRKACA, PRKCA, ATP6V1B2, ATP6V1A, ATP6V1C2, ATP6V0A1, TCIRG1, ATP6V1C1, ATP6V1D, PLCG1, KDELR3, ATP6V1E1, ACTG1, ATP6V1G1, PRKCG, TJP2, ATP6V0D1, PRKACB, PRKCB",1.55284196865778,0.593459819566045,FALSE +"HCC95","Input","KEGG_VIRAL_MYOCARDITIS",0.36306,1.08,0.317,733,0.675,"CAV1, MYH4, CD40, RAC2, RAC3",0.498940737782249,0.170696227168975,FALSE +"HCC95","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.24695,-0.72,0.861,6641,0.93,"PPP2R5B, CAMK2D, CTNNB1, DAAM2, WNT11, CXXC4, GSK3B, NFAT5, PPP2R5A, ROCK1, ROCK2, PPP3CC, CACYBP, PRKACA, PRKCA, DAAM1, PPP2CB, CTBP2, PRKCG, VANGL2, NKD1, NKD2, FOSL1, PPP3R1, PPP3R2, PRKACB, PRKCB, NFATC2, PSEN1, SMAD2",0.0649968485463452,0.0315170514460649,FALSE +"H1650","Input","KEGG_ABC_TRANSPORTERS",-0.42713,-1.31,0.159,7453,0.456,"ABCC10, ABCC2, ABCD4, ABCA10, ABCB1, ABCA3, ABCC5, ABCB6, ABCC4, ABCB4",0.798602875679548,0.341035157335565,FALSE +"H1650","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.18586,-0.576,0.951,7475,0.985,"STAT5A, STAT5B, PIM1, IKBKB, EIF4EBP1, MYC",0.0218194830625861,0.00656376950238827,FALSE +"H1650","Input","KEGG_ADHERENS_JUNCTION",0.37331,1.13,0.293,2728,0.479,"ERBB2, CTNNA1, CTNNB1, NECTIN1, TGFBR2, CTNND1, CTNNA2, EGFR, PTPRM, SMAD3, PTPRJ, PTPRF, MAPK3, MAP3K7, NECTIN2, CDH1, BAIAP2, ACTN4, PTPN1, CREBBP, EP300, ACTG1, SRC, CDC42, SMAD2, RAC1, NECTIN4, FYN, ACTN1, CSNK2A1, CSNK2A2, VCL, ACTB, RHOA, PTPN6",0.533132379645891,0.319664486585437,FALSE +"H1650","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.44472,1.39,0.101,2213,0.368,"CD36, PRKCQ, RXRA, SLC2A1, ACSL1, TRADD, ACSL5, ACSL6, STAT3, AKT2, AKT3, PRKAA1, MTOR, CHUK, ACACB, CPT1A, NFKB1",0.995678626217357,0.434152181326482,FALSE +"H1650","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.49748,1.52,0.0607,1055,0.335,"ABAT, GLUL, ASS1, GLS, GLS2, GPT2",1.21681130892474,0.474955192963155,FALSE +"H1650","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.32604,0.993,0.422,1661,0.628,"ATP1B3, SFN, ATP1B1, MAPK3, ATP1A3, PIK3R3, ATP1A1, ATP1A4, PRKCA",0.374687549038326,0.202040356262804,FALSE +"H1650","Input","KEGG_ALZHEIMERS_DISEASE",0.19217,0.604,0.962,1731,0.977,"NDUFA2, PPP3R2, MME, PPP3R1, CAPN2, PPP3CA, CAPN1, PPP3CB, CYC1, UQCR10, SDHD, ITPR2, FAS, GAPDH, CASP7, MAPK3, ATP2A2, EIF2AK3, SDHC, CYCS, GNAQ, COX6A1, CASP8",0.0168249279621871,0.0101054362812269,FALSE +"H1650","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.45506,-1.41,0.111,6631,0.423,"MARS2, MTFMT, PARS2, HARS2, AARS2, NARS2, CARS2, TARS2, WARS2",0.954677021213343,0.373659632624958,FALSE +"H1650","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.24495,0.77,0.763,1750,0.837,"PGM1, MPI, NAGK, GNE, UGP2, UAP1, CYB5R3, GMPPB, GMPPA, HEXA, HK1",0.11747546204512,0.07727454200674,FALSE +"H1650","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.30793,-0.954,0.478,8445,0.656,"NEFH, NEFM, PRPH, PRPH2, NEFL, TP53",0.320572103387881,0.18309616062434,FALSE +"H1650","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.60892,1.87,0.0208,1015,0.182,"CD74, HSPA2, HSPA1L, TAPBP, CTSL, B2M, TAP1, HSPA6, TAP2",1.68193666503724,0.739928612014925,TRUE +"H1650","Input","KEGG_APOPTOSIS",0.39026,1.15,0.265,1731,0.483,"PPP3R2, ENDOD1, PPP3R1, PRKACB, CAPN2, PPP3CA, CAPN1, PPP3CB, PRKAR1B, TRADD, ENDOG, PRKAR1A, FAS, MYD88, CASP7, AKT2, AKT3, PIK3R3, CYCS, PRKACA, CASP8",0.576754126063192,0.316052869248488,FALSE +"H1650","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.45723,1.33,0.157,485,0.357,"PTGES, GGT1, CYP4F3, GPX6, GPX7",0.804100347590766,0.447331783887807,FALSE +"H1650","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.29352,0.896,0.566,1107,0.704,"GLUL, ALDH7A1, GATM, P4HA1, PYCR3, ASS1, AOC1, DAO, GLS, GLS2, OAT, P4HA2",0.247183568811729,0.152427340857888,FALSE +"H1650","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.46079,1.41,0.121,1475,0.362,"ITGA4, ITGA6, ITGA3, ITGB4, ITGA1, ITGB1, ITGA2, ITGA5, SLC8A1, CTNNA1, CTNNB1, ITGB5, DSC2, CTNNA2, DSG2, DAG1, ITGAV, ITGB8, PKP2, ACTN4, ATP2A2, LMNA",0.91721462968355,0.441291429466834,FALSE +"H1650","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.57795,-1.77,0.0333,8393,0.366,"UGDH, ALDH2, ALDH1B1",1.47755576649368,0.436518914605589,FALSE +"H1650","Input","KEGG_AXON_GUIDANCE",0.25901,0.824,0.676,1221,0.795,"ITGB1, PPP3R2, EPHB2, NFAT5, PPP3R1, SEMA3C, EFNA5, PPP3CA, PPP3CB, EPHB4, NTN4, SEMA4B, PTK2, SRGAP2, SRGAP3, RASA1, LIMK2, CFL2, MAPK3",0.170053304058364,0.0996328713435297,FALSE +"H1650","Input","KEGG_BASAL_CELL_CARCINOMA",0.44841,1.37,0.123,763,0.358,"FZD2, FZD1, CTNNB1, APC",0.910094888560602,0.446116973356126,FALSE +"H1650","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.57937,-1.82,0.0245,6190,0.498,"TAF12, GTF2E1, TAF7, TAF10, TAF9, GTF2E2, GTF2IRD1, GTF2H3, GTF2H4, GTF2H2, GTF2H1, GTF2F2, GTF2F1, TAF9B",1.61083391563547,0.302770657240282,FALSE +"H1650","Input","KEGG_BASE_EXCISION_REPAIR",-0.49377,-1.53,0.0873,7094,0.331,"MBD4, POLE3, APEX1, MPG, FEN1, PARP1, PARP2, HMGB1, POLB",1.05898575629443,0.480172006224281,FALSE +"H1650","Input","KEGG_BETA_ALANINE_METABOLISM",0.43588,1.33,0.154,330,0.357,"ABAT, ALDH7A1",0.812479279163537,0.447331783887807,FALSE +"H1650","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.76918,2.38,0,966,0.0373,"ACOT4, SCD5, ACOT1, ACOX3, FADS2, SCD, ACOT2, ACAA1, TECR, ACOX1",Inf,1.42829116819131,TRUE +"H1650","Input","KEGG_BLADDER_CANCER",-0.35229,-1.09,0.305,8588,0.604,"E2F3, RB1, TP53, MYC",0.515700160653214,0.218963061378868,FALSE +"H1650","Input","KEGG_BUTANOATE_METABOLISM",0.31998,0.986,0.424,2397,0.626,"ABAT, ALDH7A1, ALDH3A2, OXCT1, AKR1B10, ACAT2, AACS, HMGCS1, ALDH5A1, EHHADH",0.372634143407267,0.20342566678957,FALSE +"H1650","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.31122,0.951,0.442,1393,0.646,"PPP3R2, NFAT5, MALT1, PPP3R1, PPP3CA, PPP3CB, VAV2, MAPK3, AKT2, AKT3, PIK3R3, SOS1",0.354577730650908,0.189767482004916,FALSE +"H1650","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.47802,1.48,0.106,1687,0.349,"GNA15, CAMK2G, ERBB4, BST1, PPP3R2, CAMK2B, ERBB2, PTK2B, PPP3R1, PRKACB, SLC8A1, PPP3CA, PPP3CB, PLCD1, PHKB, PHKA1, CAMK2D, EGFR, ATP2B1, TACR1, ITPR2, GNAS, ATP2B2, ATP2B4, ADCY3, ADCY8, P2RX4, SPHK2, VDAC2, ATP2A2, TNNC1, PRKACA, PRKCA, GNAQ",0.97469413473523,0.45717457304082,FALSE +"H1650","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.5211,1.59,0.0626,2768,0.317,"TPM2, SLC8A1, CYC1, UQCR10, TPM1, SLC9A6, SLC9A1, ATP1B3, ATP1B1, ATP1A3, ATP2A2, ATP1A1, ATP1A4, TNNC1, COX6A1, UQCRC2, UQCRFS1, CACNA2D2, UQCRC1, UQCRQ, COX6B1, COX7A2, COX7A2L, COX4I1, UQCRH, TPM4",1.20342566678957,0.498940737782249,FALSE +"H1650","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.50982,1.57,0.0522,1325,0.326,"ITGA4, CD40, SDC1, CLDN6, SDC4, ITGA6, ITGB2, CD99, GLG1, ITGB1, CLDN4, CD274, CDH15, CDH3, F11R, SDC2, NECTIN1, OCLN, PVR, SDC3, ITGAV, PTPRM, CD276, PTPRF, ITGB8, NECTIN2, CDH1",1.28232949699774,0.486782399932061,FALSE +"H1650","Input","KEGG_CELL_CYCLE",-0.3834,-1.17,0.238,6889,0.512,"ORC4, MCM5, CDK7, ORC5, MCM2, MCM4, CDK6, STAG1, ORC3, MCM6, MCM7, CDKN2C, TGFB2, ORC1, TGFB3, MCM3, ORC2, HDAC2, ATM, ORC6, TFDP1, CDC20, ABL1, E2F3, RB1, TP53, MYC, CDKN1B",0.623423042943488,0.290730039024169,FALSE +"H1650","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.35263,1.1,0.333,1817,0.511,"STAT1, STAT2, PTK2B, PRKACB, ADCY6, TIAM1, ADCY5, PRKCD, PRKCZ, CCL15, VAV2, PTK2, ADCY3, ADCY8, GNG10, STAT3, TIAM2, MAPK3, ARRB1, AKT2, AKT3, PIK3R3, SOS1, PXN, CXCL6, GNG12, LYN, PRKACA, CXCR4, GNG5, ROCK1, RAP1A",0.47755576649368,0.291579099865287,FALSE +"H1650","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.41892,-1.3,0.167,7475,0.427,"STAT5A, CTBP1, TGFB2, STAT5B, TGFB3, TGFBR1, HDAC2, IKBKB, ABL1, E2F3, RB1, GAB2, TP53, MYC, CDKN1B",0.777283528852417,0.369572124974976,FALSE +"H1650","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.34031,1.01,0.409,2573,0.606,"SDHD, ACLY, OGDHL, PC, SDHC, OGDH, ACO2, SUCLG2, SDHB, IDH1, MDH1, DLD, SDHA, IDH2",0.388276691992658,0.217527375833714,FALSE +"H1650","Input","KEGG_COLORECTAL_CANCER",-0.21185,-0.653,0.915,7444,0.934,"MAPK8, TGFB2, TGFB3, TGFBR1, JUN, TP53, MYC",0.0385789059335517,0.0296531237699066,FALSE +"H1650","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.36354,1.09,0.33,973,0.52,"SERPINA1, PLAU, CD59, F8, CD55, PROC, C3, MBL2, PLAUR",0.481486060122112,0.283996656365201,FALSE +"H1650","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.53674,-1.66,0.0454,7781,0.306,"MPST, APIP, AMD1, CTH, MTAP",1.3429441471429,0.51427857351842,FALSE +"H1650","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.428,1.35,0.125,1738,0.356,"CD40, IFNGR1, IL18, TGFBR2, CCL15, KITLG, EGFR, LTBR, FAS, TNFRSF12A, HGF, CXCL6, FLT3, CXCR4, EPO",0.903089986991944,0.448550002027125,FALSE +"H1650","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.40082,1.23,0.187,640,0.407,"DDX58, CASP1, IL18, IRF3, ZBP1",0.728158393463501,0.39040559077478,FALSE +"H1650","Input","KEGG_DILATED_CARDIOMYOPATHY",0.48962,1.54,0.0732,1200,0.337,"ITGA4, ITGA6, ITGA3, ITGB4, TPM2, ITGA1, ITGB1, ITGA2, ITGA5, PRKACB, ADCY6, SLC8A1, ITGB5, ADCY5, TPM1, DAG1, GNAS, ITGAV, ADCY3, ADCY8, ITGB8",1.13548891894161,0.472370099128661,FALSE +"H1650","Input","KEGG_DNA_REPLICATION",-0.53658,-1.69,0.0382,5305,0.31,"SSBP1, POLD3, RFC2, RFC3, RFC5, RPA3, POLD2, RPA2, RPA1, RNASEH1, DNA2, PRIM1, RFC1, POLA1, MCM5, RFC4, MCM2, MCM4, POLE3, MCM6, PRIM2, MCM7, POLA2, FEN1, MCM3, RNASEH2A, RNASEH2C, RNASEH2B",1.41793663708829,0.508638306165727,FALSE +"H1650","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.48056,1.47,0.0934,2564,0.35,"EGFR, NOTCH3, MAPK3, SOS1, NOTCH2, SPIRE1",1.02965312376991,0.455931955649724,FALSE +"H1650","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.588,-1.79,0.0434,7630,0.421,"ADH4, ADH7, GSTZ1, FMO3, ALDH3A1, GSTM4, ADH1C, GSTM3, MAOA, GSTM2, GSTM1, GSTP1",1.36251027048749,0.375717904164332,FALSE +"H1650","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.37646,1.16,0.232,1024,0.475,"CDA, TYMP, TK1, TK2, CES1, CES2",0.6345120151091,0.323306390375133,FALSE +"H1650","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.52697,1.63,0.0351,1250,0.299,"ITGA4, SDC1, SDC4, ITGA6, ITGA3, ITGB4, CD36, ITGA1, ITGB1, LAMA5, ITGA2, ITGA5, SDC2, ITGB5, LAMA3, LAMA4, DAG1, SDC3, ITGAV, LAMB1, ITGB8, COL5A1",1.45469288353418,0.52432881167557,FALSE +"H1650","Input","KEGG_ENDOCYTOSIS",0.52654,1.64,0.0393,2260,0.319,"DNM3, HSPA2, TRAF6, EHD2, HSPA1L, EPN3, ERBB4, ASAP3, DAB2, EHD1, RAB31, PLD2, ASAP2, DNAJC6, PRKCZ, RAB11FIP5, RAB11A, EHD3, LDLRAP1, EGFR, HSPA6, AP2A1, PRKCI, SH3GLB2, PARD6B, ITCH, WWP1, PARD6G, RAB22A, AP2B1, TFRC, PSD, AP2S1, AP2M1, IQSEC1, ARRB1, PIKFYVE, VPS4A, EPN1, DNM1, VPS4B, ASAP1, RAB11B, NEDD4, PDCD6IP, HSPA1A, CHMP5, VPS45, CXCR4, SH3KBP1, RAB11FIP2, USP8, CBLB, EHD4, CLTC, SRC, ARF6, RBSN, CDC42, CHMP2A, EPN2, DNM2, RAB5B, RAB5C, ARFGAP1, ARFGAP3, VPS37B, STAMBP, RUFY1, EPS15, RAB4A",1.40560744962457,0.496209316942819,FALSE +"H1650","Input","KEGG_ENDOMETRIAL_CANCER",0.38149,1.17,0.24,1393,0.467,"ERBB2, CTNNA1, CTNNB1, CTNNA2, APC, EGFR, MAPK3, AKT2, CDH1, AKT3, PIK3R3, SOS1",0.619788758288394,0.330683119433888,FALSE +"H1650","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.27897,-0.865,0.588,6538,0.701,"ATP6V1B2, ATP6V0A2, PAK1, ATP6V1A, ATP6V1D, ATP6V1F, GIT1, MAPK8, ATP6V1G1, ATP6V1H, ATP6V1B1, IKBKB, JUN, JAM3",0.230622673923862,0.154281982033341,FALSE +"H1650","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.22638,0.682,0.869,1393,0.927,"CAMK2G, ERBB4, CAMK2B, ERBB2, CAMK2D, PTK2, EGFR, GAB1, MAPK3, AKT2, AKT3, PIK3R3, SOS1",0.0609802235513335,0.0329202658555029,FALSE +"H1650","Input","KEGG_ETHER_LIPID_METABOLISM",0.63829,1.94,0.019,1323,0.16,"PLPP3, PLD2, LPCAT2, LPCAT4, PAFAH2, PLPP1, LPCAT1",1.72124639904717,0.795880017344075,TRUE +"H1650","Input","KEGG_FATTY_ACID_METABOLISM",0.28502,0.877,0.601,1307,0.725,"ACOX3, ALDH7A1, ACSL1, ACSL5, ACAA1, ACOX1, ACSL6, ALDH3A2",0.22112552799726,0.139661993429006,FALSE +"H1650","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.2185,0.673,0.901,2710,0.931,"PRKCD, VAV2, MAPK12, MAPK3, AKT2, AKT3, PIK3R3, SOS1, PRKCE, MAPK14, LYN, PRKCA, MAPK13, PLCG2, RAC1, FYN, HRAS, AKT1, MAP2K6, PLA2G12A, PIK3CB",0.045275209020937,0.0310503190186574,FALSE +"H1650","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.3819,1.17,0.25,1661,0.467,"PLPP3, DNM3, ASAP3, PLD2, ASAP2, PRKCD, AMPH, VAV2, LIMK2, VASP, CFL2, PLPP1, MAPK3, GSN, PIKFYVE, AKT2, DNM1, AKT3, PIK3R3, SPHK2, ASAP1, PRKCE, LYN, ARPC1B, PRKCA",0.602059991327962,0.330683119433888,FALSE +"H1650","Input","KEGG_FOCAL_ADHESION",0.38179,1.18,0.215,1958,0.466,"ITGA4, ITGA6, ITGA3, ITGB4, CAV2, CAV1, ITGA1, ITGB1, ARHGAP35, ERBB2, LAMA5, ITGA2, ITGA5, CAPN2, CTNNB1, ITGB5, FLNC, LAMA3, LAMA4, VAV2, PTK2, EGFR, ITGAV, LAMB1, VASP, ITGB8, MAPK3, COL5A1, AKT2, ACTN4, AKT3, PIK3R3, HGF, SOS1, PXN, MYL9, TNC, PRKCA, ROCK1, RAP1A, MYL12A, ACTG1, SRC, FLT4, CDC42",0.667561540084395,0.33161408331,FALSE +"H1650","Input","KEGG_FOLATE_BIOSYNTHESIS",0.70452,2.17,0.0053,12,0.0964,"ALPI, ALPP",2.27572413039921,1.01592296609717,TRUE +"H1650","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.25161,0.776,0.758,2497,0.834,"MPI, PFKFB4, AKR1B1, PFKP, PFKFB2, GMPPB, MTMR1, GMPPA, AKR1B10, HK1, PFKL, PMM2, ALDOA, PHPT1, HK2",0.120330794367946,0.0788339493622613,FALSE +"H1650","Input","KEGG_GALACTOSE_METABOLISM",0.42858,1.35,0.131,998,0.356,"PGM1, B4GALT1, UGP2, GLB1, AKR1B1, PFKP",0.882728704344236,0.448550002027125,FALSE +"H1650","Input","KEGG_GAP_JUNCTION",0.3026,0.923,0.535,2086,0.684,"PRKACB, ADCY6, ADCY5, TUBA4A, EGFR, ITPR2, GNAS, ADCY3, ADCY8, MAPK3, SOS1, PRKACA, PRKCA, GNAQ, CDK1, SRC, MAPK7, GNA11",0.271646217978772,0.164943898279884,FALSE +"H1650","Input","KEGG_GLIOMA",-0.27733,-0.872,0.577,8588,0.705,"E2F3, CALM2, RB1, CALML3, TP53",0.238824186844269,0.151810883008601,FALSE +"H1650","Input","KEGG_GLUTATHIONE_METABOLISM",-0.31026,-0.965,0.46,7811,0.654,"GPX4, GSTZ1, GCLC, GPX3, GSTM4, GSTM3, GPX2, GSTM2, GSTM1, GSTP1",0.337242168318426,0.184422251675733,FALSE +"H1650","Input","KEGG_GLYCEROLIPID_METABOLISM",0.42595,1.3,0.178,1307,0.379,"PLPP3, MGLL, DGKA, CEL, ALDH7A1, MBOAT2, AKR1B1, AGPAT4, PLPP1, ALDH3A2",0.749579997691106,0.421360790031928,FALSE +"H1650","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40271,1.24,0.183,1709,0.414,"PLPP3, PEMT, DGKA, MBOAT7, PLD2, LPCAT2, LPCAT3, LPCAT4, MBOAT2, PLA2G15, AGPAT4, PISD, PLPP1, LPCAT1, DGKB, CDS1, AGPAT2",0.737548910269571,0.382999658879101,FALSE +"H1650","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.2957,-0.92,0.509,6701,0.683,"GLDC, CHDH, GAMT, SHMT2, PSPH, PIPOX, MAOA, CTH",0.293282217663241,0.165579296318467,FALSE +"H1650","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.263,-0.81,0.664,7561,0.786,"PGK2, ADH4, ADH7, FBP2, ENO2, PCK2, FBP1, GCK, ALDH3A1, ALDOC, ADH1C, ALDH2, ALDH1B1",0.177831920631982,0.104577453960592,FALSE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.61807,1.9,0.019,2827,0.174,"B3GALT6, CHST14, CHSY1, XYLT2, B3GAT3, B4GALT7",1.72124639904717,0.7594507517174,TRUE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.3413,-1.07,0.373,8794,0.597,"HS6ST2",0.428291168191312,0.224025668870631,FALSE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66224,2.02,0.0182,1356,0.126,"B4GALT1, ST3GAL2, B4GALT4",1.73992861201493,0.899629454882437,TRUE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.53564,1.67,0.032,1663,0.303,"GALNS, ARSB, GLB1, HPSE, NAGLU, HEXA",1.49485002168009,0.518557371497695,FALSE +"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.56792,1.72,0.0366,1663,0.281,"ST3GAL2, GLB1, HEXA",1.43651891460559,0.55129368009492,FALSE +"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.69372,2.12,0.00887,2389,0.0816,"ST3GAL2, HEXA, FUT1, NAGA",2.05207638016827,1.08830984124614,TRUE +"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.56773,1.74,0.0504,1356,0.278,"B3GNT3, B4GALT1, ST3GAL4, FUT3, B4GALT4",1.29756946355447,0.555955204081924,FALSE +"H1650","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.56312,1.74,0.0252,1311,0.278,"GPAA1, PIGT, PIGW, PIGS, PIGU, PIGK",1.59859945921846,0.555955204081924,FALSE +"H1650","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.37042,1.13,0.27,2268,0.479,"MTHFD2, GRHPR, ACO2, MDH1",0.568636235841013,0.319664486585437,FALSE +"H1650","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.40632,1.27,0.185,2086,0.389,"CAMK2G, CAMK2B, PTK2B, PRKACB, ADCY6, PLD2, ADCY5, PRKCD, CAMK2D, MMP2, EGFR, ITPR2, GNAS, MAPK12, ADCY3, ADCY8, MAPK3, SOS1, MAPK14, PRKACA, PRKCA, GNAQ, MAPK13, SRC, CDC42, MAPK7, GNA11",0.732828271596986,0.410050398674292,FALSE +"H1650","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.24094,-0.739,0.763,8187,0.898,"SHH, FBXW11",0.11747546204512,0.0467236633326956,FALSE +"H1650","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.702,2.15,0.0149,853,0.0898,"ITGA4, ANPEP, ITGA6, ITGA3, CD36, CD9, ITGA1, CD14, ITGA2, MME, ITGA5, CD59, CD55, KITLG",1.82681373158773,1.0467236633327,TRUE +"H1650","Input","KEGG_HISTIDINE_METABOLISM",-0.51952,-1.58,0.0791,8386,0.329,"ALDH3A1, ALDH2, HNMT, ALDH1B1, MAOA, DDC",1.10182351650232,0.482804102050026,FALSE +"H1650","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.39924,-1.28,0.195,5027,0.414,"TOP3A, MRE11, SSBP1, POLD3, RPA3, POLD2, RPA2, RPA1, TOP3B, RAD51, MUS81, BLM",0.709965388637482,0.382999658879101,FALSE +"H1650","Input","KEGG_HUNTINGTONS_DISEASE",0.13224,0.408,0.998,1932,1,"TGM2, NDUFA2, DNAH2, CYC1, UQCR10, SDHD, AP2A1, AP2B1, AP2S1, AP2M1, VDAC2, CREBBP, SDHC, EP300, CYCS, GNAQ, COX6A1, CASP8, UQCRC2, CLTC, UQCRFS1",0.000869458712628891,0,FALSE +"H1650","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.45307,1.4,0.107,731,0.366,"ITGA4, ITGA6, ITGA3, ITGB4, TPM2, ITGA1, ITGB1, ITGA2, ITGA5, SLC8A1, ITGB5, ACE, TPM1, DAG1",0.97061622231479,0.436518914605589,FALSE +"H1650","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.25755,0.78,0.715,3028,0.835,"INPP4B, MINPP1, PLCD1, IMPA2, ITPK1, PI4KA, PIKFYVE, PIK3C2B, ISYNA1, INPP5K, PLCG2, INPP4A, PIK3C3, INPP1, INPPL1, PIP4K2C, PIK3CB, INPP5A, PIK3CA, PIK3CD, SYNJ1, PLCD3",0.145693958198919,0.0783135245163979,FALSE +"H1650","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.25849,0.788,0.708,1790,0.837,"PRKACB, PRKCZ, PRKAR1B, PHKB, PHKA1, PPP1R3D, PRKAR1A, PRKCI, FASN, GYS1, PTPRF, PKLR, MAPK3, AKT2, AKT3, PIK3R3, PTPN1, SOS1, PRKAA1, PPP1R3A, EXOC7, TRIP10, MTOR, ACACA, PRKACA, INPP5K, HK1, CBLB",0.149966742310231,0.07727454200674,FALSE +"H1650","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.27213,0.816,0.66,1790,0.802,"IFNGR1, STAT1, STAT2, IRF9, STAT3, AKT2, AKT3, PIK3R3, SOS1, CREBBP, EP300, EPO, CBLB",0.180456064458131,0.0958256317158365,FALSE +"H1650","Input","KEGG_LEISHMANIA_INFECTION",0.49823,1.52,0.0591,1829,0.335,"ITGA4, TRAF6, IFNGR1, STAT1, ITGB2, ITGB1, C3, MYD88, MAPK12, MAPK3, MAP3K7, MAPK14, CR1, CYBA, MAPK13",1.22841251911874,0.474955192963155,FALSE +"H1650","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.36077,1.13,0.267,1958,0.479,"ITGA4, CLDN6, ITGB2, CD99, ITGB1, CLDN4, ARHGAP35, PTK2B, F11R, CTNNA1, CTNNB1, OCLN, CTNND1, MMP2, CTNNA2, VAV2, PTK2, MAPK12, VASP, EZR, ACTN4, PIK3R3, PXN, MYL9, MAPK14, PRKCA, CXCR4, CYBA, ROCK1, RAP1A, MAPK13, MYL12A, ACTG1, MSN, CDC42",0.573488738635425,0.319664486585437,FALSE +"H1650","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.4291,-1.34,0.145,8635,0.465,"ALDH2, ALDH1B1",0.838631997765025,0.332547047110046,FALSE +"H1650","Input","KEGG_LONG_TERM_DEPRESSION",0.22147,0.692,0.883,2091,0.922,"GNAO1, ITPR2, GNAS, MAPK3, LYN, PRKCA, GNAQ, CACNA1A, GNA11, GNA12",0.0540392964224314,0.0352690789463706,FALSE +"H1650","Input","KEGG_LONG_TERM_POTENTIATION",0.41177,1.25,0.212,1817,0.408,"CAMK2G, PPP3R2, CAMK2B, PPP3R1, PRKACB, PPP3CA, PPP3CB, CAMK2D, ITPR2, ADCY8, MAPK3, CREBBP, EP300, RPS6KA1, PRKACA, PRKCA, GNAQ, RAP1A",0.673664139071249,0.38933983691012,FALSE +"H1650","Input","KEGG_LYSINE_DEGRADATION",-0.36126,-1.12,0.313,7926,0.574,"KMT5A, NSD2, SETMAR, KMT5C, PIPOX, SETDB2, NSD3, AASS, ALDH2, ALDH1B1",0.504455662453552,0.241088107602027,FALSE +"H1650","Input","KEGG_LYSOSOME",0.48056,1.49,0.0807,1219,0.348,"GALC, AP1M2, CTSH, AP1S1, LIPA, GM2A, CTSL, CTSZ, AP1G1, CTSK, CTSO, GALNS, CTSV, ARSB, GGA2, LAMP3, PLA2G15, TCIRG1, GLB1, CTSA, ARSA, MANBA, AP1B1, NAPSA, CTSF, AP1S3",1.09312646527793,0.458420756053419,FALSE +"H1650","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.33128,1.01,0.412,1661,0.606,"HSPA2, TRAF6, HSPA1L, HSPB1, CD14, PPP3R2, MAP3K5, TAOK3, PPP3R1, PRKACB, RRAS, PPP3CA, PPP3CB, TGFBR2, FLNC, MAP3K20, FGF13, FGF2, EGFR, MAPKAPK3, HSPA6, NFKB2, CDC25B, FAS, RASA1, MAPK12, MAPK8IP3, MAPK3, STK3, MAP3K7, ARRB1, AKT2, AKT3, SOS1, GNG12, HSPA1A, RPS6KA1, MAPK14, PRKACA, PRKCA",0.385102783966865,0.217527375833714,FALSE +"H1650","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.48931,-1.53,0.0732,6087,0.331,"HNF1A, HNF4A, PDX1, HES1, GCK, FOXA2",1.13548891894161,0.480172006224281,FALSE +"H1650","Input","KEGG_MELANOGENESIS",0.44204,1.37,0.136,1687,0.358,"CAMK2G, GNAO1, CAMK2B, FZD2, PRKACB, ADCY6, FZD1, CTNNB1, ADCY5, CAMK2D, KITLG, GNAS, ADCY3, ADCY8, MAPK3, CREBBP, EP300, PRKACA, PRKCA, GNAQ",0.866461091629782,0.446116973356126,FALSE +"H1650","Input","KEGG_MELANOMA",0.23353,0.718,0.843,1392,0.916,"FGF13, FGF2, EGFR, MAPK3, AKT2, CDH1, AKT3, PIK3R3, HGF",0.0741724253752577,0.0381045263321496,FALSE +"H1650","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.54792,-1.69,0.0407,7630,0.31,"ADH4, ADH7, GSTZ1, ALDH3A1, GSTM4, ADH1C, AKR1C2, AKR1C1, GSTM3, AKR1C3, GSTM2, GSTM1, GSTP1",1.39040559077478,0.508638306165727,FALSE +"H1650","Input","KEGG_MISMATCH_REPAIR",-0.40526,-1.29,0.181,5305,0.42,"SSBP1, POLD3, RFC2, RFC3, RFC5, RPA3, POLD2, RPA2, RPA1, MSH2, RFC1, MSH6, RFC4",0.742321425130815,0.3767507096021,FALSE +"H1650","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.30813,0.965,0.442,3004,0.65,"MAPK3, AKT2, AKT3, PIK3R3, PRKAA1, CAB39, RICTOR, RPS6KA1, MTOR, RPTOR, TSC2, AKT1, RPS6KA3, RHEB, PIK3CB, PIK3CA, RPS6KA6, PIK3CD, RPS6KA2, PDPK1",0.354577730650908,0.187086643357144,FALSE +"H1650","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.4509,1.37,0.122,1393,0.358,"IFNGR1, ITGB2, RAET1L, ULBP2, PPP3R2, NFAT5, PTK2B, PPP3R1, PPP3CA, PPP3CB, VAV2, FAS, MAPK3, PIK3R3, SOS1",0.913640169325252,0.446116973356126,FALSE +"H1650","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.34133,-1.05,0.364,7011,0.614,"PARD3, P2RY11, GRIN1, CHRM3, CGA, LTB4R2, F2",0.438898616350944,0.211831628858832,FALSE +"H1650","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.21656,0.67,0.892,2954,0.927,"TRAF6, CAMK2G, CAMK2B, MAP3K5, ARHGDIB, PRKCD, CAMK2D, SH2B1, YWHAZ, GAB1, MAPK12, MAPK3, AKT2, AKT3, PIK3R3, SOS1, RPS6KA1, MAPK14, YWHAB, RAP1A, MAPK13, CDC42, MAPK7, PLCG2, NFKB1, RAC1, YWHAE, HRAS, MAPKAPK2, MAP3K3, AKT1, RPS6KA3, RIPK2, PIK3CB, RHOA, BCL2, RPS6KA4, IRS1, PIK3CA, RPS6KA6, MAGED1, PIK3CD, RPS6KA2",0.0496351456238769,0.0329202658555029,FALSE +"H1650","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.44745,1.35,0.128,205,0.356,"NNMT, QPRT, BST1",0.892790030352132,0.448550002027125,FALSE +"H1650","Input","KEGG_NITROGEN_METABOLISM",-0.4414,-1.36,0.133,7821,0.466,"GLUD2, CPS1, CA14, CA1, ASNS, CTH, CA8",0.876148359032914,0.33161408331,FALSE +"H1650","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.37018,1.12,0.293,1987,0.488,"TRAF6, CASP1, IL18, NAIP, MAPK12, MAPK3, MAP3K7, MAPK14, CASP8, CASP5, MAPK13, CHUK, PYCARD",0.533132379645891,0.311580177997289,FALSE +"H1650","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.46852,-1.44,0.114,4762,0.413,"NHEJ1, MRE11, PRKDC, XRCC4, POLM, FEN1",0.943095148663527,0.384049948343599,FALSE +"H1650","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.30704,-0.947,0.487,8588,0.652,"E2F3, RB1, FOXO3, FHIT, TP53",0.312471038785366,0.18575240426808,FALSE +"H1650","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.22704,-0.709,0.827,7053,0.911,"HES1, SNW1, LFNG, KAT2A, CTBP1, DLL3, HDAC2, JAG1",0.0824944904474534,0.0404816230270017,FALSE +"H1650","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.42132,-1.3,0.182,5584,0.427,"RFC3, RFC5, RPA3, POLD2, XPC, RPA2, RPA1, CCNH, ERCC8, RFC1, CDK7, RFC4, POLE3, ERCC6, ERCC3, GTF2H5, CUL4A, GTF2H3, GTF2H4, GTF2H2, GTF2H1, MNAT1, ERCC5",0.739928612014925,0.369572124974976,FALSE +"H1650","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.33445,1.05,0.325,2219,0.55,"B4GALT1, MAN2A2, MAN1B1, MAN2A1, TUSC3, STT3B, ALG2, MGAT1, DPM1, GANAB, MAN1A2, RFT1, DDOST",0.488116639021126,0.259637310505756,FALSE +"H1650","Input","KEGG_OLFACTORY_TRANSDUCTION",0.36076,1.08,0.312,668,0.515,"CAMK2G, CAMK2B, PRKACB, CAMK2D",0.505845405981557,0.288192770958809,FALSE +"H1650","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.22552,-0.683,0.827,5223,0.932,"TYMS, ATIC, MTHFD1L, MTR, MTFMT, SHMT2",0.0824944904474534,0.0305840876460186,FALSE +"H1650","Input","KEGG_OOCYTE_MEIOSIS",0.41873,1.28,0.158,1812,0.383,"CAMK2G, PPP3R2, CAMK2B, PPP3R1, PRKACB, ADCY6, PPP3CA, PPP3CB, ADCY5, CAMK2D, AR, ITPR2, PPP2R5E, YWHAZ, MAPK12, ADCY3, ADCY8, PLK1, MAPK3, SKP1, RPS6KA1, PRKACA, PPP2R5A, CDK1, YWHAB",0.801342913045577,0.416801226031377,FALSE +"H1650","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.35693,1.08,0.323,1663,0.515,"GLB1, MANBA, MAN2B2, HEXA",0.490797477668897,0.288192770958809,FALSE +"H1650","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.13403,0.408,1,2760,1,"NDUFA2, CYC1, UQCR10, LHPP, TCIRG1, SDHD, COX15, SDHC, COX6A1, ATP12A, ATP6V1C2, UQCRC2, UQCRFS1, SDHB, ATP6V1C1, UQCRC1, NDUFA3, UQCRQ, SDHA, COX17, COX6B1, COX7A2, COX7A2L, COX4I1, NDUFA4, UQCRH",0,0,FALSE +"H1650","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.81624,2.48,0,683,0.0195,"GALNT6, C1GALT1, C1GALT1C1, GALNT14, GALNT15, GALNT10, GALNT13, GALNT7, GALNT3, GALNT12, GALNT2, ST3GAL2, B4GALT5",Inf,1.70996538863748,TRUE +"H1650","Input","KEGG_P53_SIGNALING_PATHWAY",0.44078,1.34,0.15,1793,0.36,"TP53I3, SERPINB5, CD82, EI24, RRM2, DDB2, FAS, RRM2B, SFN, IGFBP3, CYCS, CHEK2, CASP8, CDK1",0.823908740944319,0.443697499232713,FALSE +"H1650","Input","KEGG_PANCREATIC_CANCER",0.2311,0.712,0.846,2235,0.909,"STAT1, ERBB2, TGFBR2, EGFR, SMAD3, RALA, STAT3, MAPK3, AKT2, AKT3, PIK3R3, RALB, CDC42, JAK1, CHUK, SMAD2, NFKB1, RAC1",0.0726296369609765,0.0414361167780325,FALSE +"H1650","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.3653,1.14,0.253,1470,0.491,"PPCS, BCAT2, PANK4",0.596879478824182,0.308918507877032,FALSE +"H1650","Input","KEGG_PARKINSONS_DISEASE",0.19018,0.579,0.968,837,0.985,"UBE2L6, UBA7, NDUFA2, CYC1, UQCR10, SDHD",0.0141246426916063,0.00656376950238827,FALSE +"H1650","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.31159,0.96,0.459,1958,0.652,"ITGB1, CD14, CTNNB1, OCLN, TUBA4A, YWHAZ, CDH1, EZR, ARPC1B, PRKCA, ROCK1, ACTG1, CDC42",0.338187314462739,0.18575240426808,FALSE +"H1650","Input","KEGG_PATHWAYS_IN_CANCER",0.27649,0.847,0.635,1661,0.766,"TRAF6, ITGA6, STAT1, ITGA3, ITGB1, ERBB2, LAMA5, ITGA2, FZD2, RXRA, FZD1, CTNNA1, CTNNB1, SLC2A1, TGFBR2, MMP2, LAMA3, LAMA4, CTNNA2, APC, FGF13, FGF2, KITLG, AR, PTK2, EGFR, NFKB2, ITGAV, FAS, LAMB1, SMAD3, RARA, RALA, STAT3, MAPK3, AKT2, CDH1, AKT3, PIK3R3, HGF, SOS1, DAPK1, CKS1B, CREBBP, FLT3, EP300, MTOR, CYCS, PRKCA",0.197226274708024,0.115771230367396,FALSE +"H1650","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.42783,-1.32,0.168,8393,0.467,"UGDH, CRYL1",0.774690718274137,0.330683119433888,FALSE +"H1650","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.27629,0.829,0.654,998,0.793,"PGM1, RBKS, H6PD, PFKP",0.184422251675733,0.100726812682396,FALSE +"H1650","Input","KEGG_PEROXISOME",0.48695,1.5,0.0873,2573,0.348,"PXMP4, ACOX3, SLC25A17, DECR2, MVK, ECH1, ACSL1, ACSL5, ACOT8, ACAA1, ABCD1, CROT, DAO, AMACR, ACOX1, GSTK1, HACL1, ACSL6, PEX13, HSD17B4, ABCD3, CAT, CRAT, PXMP2, PEX3, PEX14, PEX11A, AGPS, SCP2, ECI2, IDH1, PRDX1, EHHADH, ACSL3, PRDX5, NUDT19, PEX26, IDH2",1.05898575629443,0.458420756053419,FALSE +"H1650","Input","KEGG_PHENYLALANINE_METABOLISM",-0.59458,-1.82,0.0289,8386,0.498,"ALDH3A1, MAOA, DDC",1.53910215724345,0.302770657240282,FALSE +"H1650","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25482,0.785,0.712,1672,0.835,"INPP4B, DGKA, PLCD1, IMPA2, ITPR2, ITPK1, PI4KA, PIKFYVE, PIK3R3, PIK3C2B, DGKB, CDS1, PRKCA, INPP5K",0.147520006363144,0.0783135245163979,FALSE +"H1650","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.53052,1.6,0.0613,1730,0.32,"CP, EARS2, FTH1, BLVRB, COX15, HCCS, HMOX1, UROS, FECH",1.21253952548158,0.494850021680094,FALSE +"H1650","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.39589,1.23,0.198,1093,0.407,"SCD5, CD36, SLC27A6, ACOX3, FADS2, SCD, RXRA, ACSL1, ACSL5, SLC27A4, ACAA1, ACOX1, ACSL6",0.703334809738469,0.39040559077478,FALSE +"H1650","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.41756,1.29,0.149,1109,0.385,"CYP7B1, AMACR, HSD17B4",0.826813731587726,0.414539270491499,FALSE +"H1650","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.52972,1.63,0.0531,1156,0.299,"CD40, TAP1, TAP2, ADA",1.27490547891853,0.52432881167557,FALSE +"H1650","Input","KEGG_PRION_DISEASES",-0.32333,-1.01,0.406,8618,0.627,"C9, NCAM1",0.391473966422806,0.202732459169284,FALSE +"H1650","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.40222,1.21,0.22,1829,0.428,"PRKACB, ADCY6, ADCY5, CDC25B, MAPK12, ADCY3, ADCY8, PLK1, MAPK3, AKT2, FZR1, AKT3, PIK3R3, RPS6KA1, MAPK14, PRKACA, CDK1, MAPK13",0.657577319177794,0.368556230986828,FALSE +"H1650","Input","KEGG_PROPANOATE_METABOLISM",-0.28258,-0.878,0.53,8180,0.71,"ACSS3, PCCB, ALDH6A1, PCCA, ALDH2, ALDH1B1",0.275724130399211,0.148741651280925,FALSE +"H1650","Input","KEGG_PROSTATE_CANCER",-0.31824,-0.976,0.452,8368,0.652,"IKBKB, E2F3, RB1, TP53, GSTP1, CDKN1B",0.344861565188618,0.18575240426808,FALSE +"H1650","Input","KEGG_PROTEASOME",0.31048,0.967,0.465,263,0.654,"PSMB10, PSMB9",0.332547047110046,0.184422251675733,FALSE +"H1650","Input","KEGG_PROTEIN_EXPORT",-0.16757,-0.505,0.995,1481,0.992,"SEC62, SRP19, SRP54, SRPRA, SRP68, SRP72, SPCS1, HSPA5, SPCS3, SRPRB, SPCS2, SEC11A, OXA1L, IMMP1L, SEC61B, SRP14, SEC61A1, SRP9, SEC63, SEC11C",0.00217691925427455,0.00348832784582135,FALSE +"H1650","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.43619,1.31,0.14,2268,0.373,"GLS, GLS2, ATP1B3, ATP1B1, ATP1A3, ATP1A1, ATP1A4, CA2, MDH1",0.853871964321762,0.428291168191312,FALSE +"H1650","Input","KEGG_PURINE_METABOLISM",-0.22859,-0.717,0.81,5972,0.917,"APRT, POLR3F, GMPS, POLR1B, POLR1A, POLR2I, PRPS1, PRPS1L1, POLR3H, POLR3G, POLR2D, POLR1E, NME2, PDE6D, GUK1, POLR3C, ITPA, PRIM1, POLR2C, POLR2H, NUDT2, POLA1, POLR2L, PNP, PFAS, AK2, POLR2E, NME7, POLE3, AK1, NT5C, PRIM2, NUDT5, NME1, AK5, POLA2, GMPR2, PDE3A, PDE4A, PDE1C, POLR1C, POLR1D, GMPR, XDH, IMPDH1, NPR2, FHIT",0.0915149811213502,0.0376306643299789,FALSE +"H1650","Input","KEGG_PYRIMIDINE_METABOLISM",0.19702,0.616,0.954,1078,0.976,"CDA, CMPK2, NME3, TYMP, RRM2, NME4, TK1, TK2, DHODH, RRM2B",0.0204516252959049,0.0105501823333082,FALSE +"H1650","Input","KEGG_PYRUVATE_METABOLISM",0.23467,0.708,0.83,2433,0.907,"ALDH7A1, ACSS2, AKR1B1, ME3, PKLR, ALDH3A2, PC, ACACA, GRHPR, ACAT2, ACSS1, ACACB, MDH1, DLD, ME2",0.0809219076239261,0.0423927129399047,FALSE +"H1650","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.40176,1.23,0.201,1645,0.407,"ITGA4, ITGA6, ITGA3, ITGB4, ITGB2, ITGA1, ITGB1, CD14, MYH14, ARHGAP35, ITGA2, ITGA5, RDX, RRAS, TIAM1, ITGB5, FGD3, APC, FGF13, FGF2, VAV2, PTK2, EGFR, SLC9A1, ITGAV, LIMK2, CFL2, MYH9, ITGB8, TIAM2, MAPK3, GSN, PIKFYVE, BAIAP2, EZR, ACTN4, PIK3R3, SOS1, PXN, GNG12, MYL9, ARPC1B, CYFIP2, NCKAP1",0.696803942579511,0.39040559077478,FALSE +"H1650","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.28536,0.868,0.61,2369,0.735,"GABARAPL2, GABARAPL1, PRKAA1, PIK3R4, ATG4B, ATG4A, PIK3C3",0.214670164989233,0.133712660915805,FALSE +"H1650","Input","KEGG_RENAL_CELL_CARCINOMA",0.22774,0.715,0.826,3477,0.912,"SLC2A1, GAB1, MAPK3, AKT2, AKT3, PIK3R3, HGF, SOS1, CREBBP, EP300, RAP1A, CDC42, RAC1, HRAS, PAK5, PAK6, AKT1, CUL2, PAK4, PIK3CB, PIK3CA, PIK3CD, ELOB, CRKL, PIK3R2, RBX1, MAPK1, MAP2K1, FLCN, PAK2, KRAS, NRAS",0.0830199526796178,0.0400051616715838,FALSE +"H1650","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.6738,2.12,0.00742,843,0.0816,"CPA3, ANPEP, MME, ACE, CTSA",2.12959609472097,1.08830984124614,TRUE +"H1650","Input","KEGG_RETINOL_METABOLISM",-0.33223,-1.04,0.344,7630,0.613,"ADH4, ADH7, ADH1C, ALDH1A1, ALDH1A2",0.46344155742847,0.212539525481585,FALSE +"H1650","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.32563,-1.03,0.389,5705,0.612,"ACP1, FLAD1, TYR, MTMR6, ACP5, RFK",0.410050398674292,0.213248577854439,FALSE +"H1650","Input","KEGG_RIBOSOME",-0.37685,-1.17,0.241,4360,0.512,"RPS2, RPS19, RPL3, RPL23, RPL21, RPS17, RPL7A, RPL9, RPS9, RPSA, RPL17, MRPL13, RPL13, RPL6, RPS13, RPLP2, RPS5, RPS7, RPL31, RPL4, RPL32, RPL19, RPL22, RPL27A, RPS29, RPS27A, RPL29, RPLP1, RPS25, RPS28, UBA52, RPS27L, RPS20, FAU, RPS11, RPS12, RPS10, RPL24, RSL24D1, RPL36A, RPL36AL, RPS21, RPS6, RPS23, RPL38, RPL37, RPL22L1",0.617982957425132,0.290730039024169,FALSE +"H1650","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.46886,1.45,0.108,2213,0.343,"TRAF6, DDX58, ISG15, PIN1, IRF3, TRADD, CYLD, MAPK12, TRIM25, MAP3K7, MAPK14, CASP8, TKFC, MAPK13, CASP10, CHUK, TBK1, NFKB1",0.96657624451305,0.464705879957229,FALSE +"H1650","Input","KEGG_RNA_DEGRADATION",-0.28274,-0.897,0.55,5355,0.692,"EXOSC6, XRN2, DCP2, EXOSC9, EXOSC10, EXOSC5, LSM6, DIS3, LSM8, EDC3, EXOSC8, EXOSC1, MPHOSPH6, EXOSC4, LSM1, PAPOLG, HSPD1, LSM2, DDX6, CNOT2, LSM7, ENO2, LSM4, DCP1B",0.259637310505756,0.159893905543242,FALSE +"H1650","Input","KEGG_RNA_POLYMERASE",-0.53795,-1.64,0.0554,5344,0.294,"POLR3D, POLR2G, POLR3K, POLR3GL, POLR2J, POLR3F, POLR1B, POLR1A, POLR2I, POLR3H, POLR3G, POLR2D, POLR1E, POLR3C, POLR2C, POLR2H, POLR2L, POLR2E, POLR1C, POLR1D",1.25649023527157,0.531652669587843,FALSE +"H1650","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.36514,1.13,0.257,123,0.479,"GGT1, PAPSS2",0.590066876668705,0.319664486585437,FALSE +"H1650","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.29059,-0.904,0.559,8190,0.696,"FN1, LAMA1, IKBKB, E2F3, RB1, PTGS2, FHIT, TP53, MYC, ITGA2B, CDKN1B",0.252588192113577,0.157390760389438,FALSE +"H1650","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.28169,0.881,0.564,2752,0.724,"VAMP8, BET1L, YKT6, STX16, VAMP3, STX4, GOSR1, STX8, VAMP2, SNAP47, VAMP4, STX10",0.248720896016658,0.140261433802853,FALSE +"H1650","Input","KEGG_SPHINGOLIPID_METABOLISM",0.54486,1.68,0.0334,1396,0.31,"PLPP3, GALC, SPTLC2, GLB1, ARSA, DEGS1, SPTLC1, PLPP1, SPHK2",1.47625353318844,0.508638306165727,FALSE +"H1650","Input","KEGG_SPLICEOSOME",-0.39623,-1.24,0.21,5458,0.449,"DHX15, PRPF31, SRSF10, ALYREF, EFTUD2, SRSF5, PRPF4, PHF5A, HNRNPK, SF3B6, EIF4A3, U2AF2, TRA2A, LSM6, RBMX, NCBP1, PLRG1, SRSF4, SF3B4, SMNDC1, HSPA8, U2SURP, CDC5L, LSM8, SNRPG, MAGOHB, DHX16, RBM25, SF3A1, PPIH, U2AF1, CHERP, PRPF19, ISY1, RBM22, SF3A2, SF3B3, PRPF18, SF3B2, RBM8A, SYF2, ZMAT2, HNRNPC, SNRPC, BCAS2, CRNKL1, NCBP2, PRPF40A, SRSF1, TCERG1, PPIE, TRA2B, PPIL1, SNW1, SRSF3, CDC40, BUD31, LSM2, SLU7, TXNL4A, LSM7, SNRNP40, DDX5, RBM17, SRSF2, SNRNP27, HNRNPM, SRSF8, HNRNPU, SART1, WBP11, PQBP1, HNRNPA3, CCDC12, ACIN1, HNRNPA1, CWC15, LSM4, SNU13",0.677780705266081,0.347753658996677,FALSE +"H1650","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.31163,0.959,0.465,1077,0.646,"PGM1, SI, UGP2, GYS1",0.332547047110046,0.189767482004916,FALSE +"H1650","Input","KEGG_STEROID_BIOSYNTHESIS",0.47462,1.46,0.081,759,0.351,"CEL, LIPA, DHCR24, SQLE, MSMO1",1.09151498112135,0.454692883534176,FALSE +"H1650","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.55675,-1.73,0.0311,8521,0.356,"HSD11B2, AKR1D1, AKR1C2, AKR1C1, AKR1C3, HSD17B8",1.50723961097316,0.448550002027125,FALSE +"H1650","Input","KEGG_SULFUR_METABOLISM",0.89874,2.66,0,196,0.00879,"SULT1A3, SULT2B1, PAPSS2, SULT1A1",Inf,2.05601112492623,TRUE +"H1650","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.47555,1.41,0.102,1378,0.362,"CD40, C3, TRIM21, ACTN4",0.991399828238082,0.441291429466834,FALSE +"H1650","Input","KEGG_TASTE_TRANSDUCTION",0.70438,2.19,0.00556,2081,0.109,"PRKACB, ADCY6, GNAS, ADCY8, PRKACA, CACNA1A",2.25492520841794,0.962573502059376,TRUE +"H1650","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.34493,1.05,0.355,2017,0.55,"MVK, MVD, HMGCR, ACAT2, HMGCS1",0.449771646944906,0.259637310505756,FALSE +"H1650","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.21329,-0.67,0.909,6297,0.931,"SP1, INHBE, AMH, RPS6KB2, SMURF2, ACVR1, CHRD, TGFB2, TGFB3, TGFBR1, TFDP1, SMAD5, MYC",0.0414361167780325,0.0310503190186574,FALSE +"H1650","Input","KEGG_THYROID_CANCER",-0.319,-1,0.427,8756,0.626,"TP53, MYC",0.369572124974976,0.20342566678957,FALSE +"H1650","Input","KEGG_TIGHT_JUNCTION",0.41238,1.28,0.16,1993,0.383,"CLDN6, EPB41L1, MYH14, MYH7B, CLDN4, MYH4, PRKCQ, RRAS, F11R, CTNNA1, CTNNB1, OCLN, PRKCD, PRKCZ, MAP3K20, CTNNA2, TJP3, PRKCI, PARD6B, LLGL2, PARD6G, MYH11, CGN, MYH9, CASK, AKT2, VAPA, ACTN4, AKT3, MYH3, PRKCE, TJP2, MAGI3, EXOC3, MYL9, PRKCA, AMOTL1, MYL12A, ACTG1, SRC, CDC42, EXOC4",0.795880017344075,0.416801226031377,FALSE +"H1650","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.45925,1.43,0.112,2235,0.358,"CD40, TRAF6, STAT1, CD14, CTSK, IRF3, MYD88, TICAM2, MAPK12, TLR9, MAPK3, MAP3K7, AKT2, AKT3, PIK3R3, MAPK14, CASP8, MAPK13, CHUK, TBK1, NFKB1, RAC1",0.950781977329818,0.446116973356126,FALSE +"H1650","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.34755,-1.07,0.311,8197,0.597,"HAAO, WARS2, ALDH2, ALDH1B1, MAOA, DDC",0.507239610973163,0.224025668870631,FALSE +"H1650","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29609,0.915,0.539,1750,0.692,"PRKCD, PRKCZ, ABCC8, PKLR, MAPK3, PIK3R3, PRKCE, MTOR, HK1",0.268411234813261,0.159893905543242,FALSE +"H1650","Input","KEGG_TYROSINE_METABOLISM",-0.61024,-1.88,0.0226,7263,1,"BUD23, METTL2B, ADH4, ADH7, TYRP1, GSTZ1, FAH, ALDH3A1, DCT, ADH1C, MAOA, DDC",1.6458915608526,0,FALSE +"H1650","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.3151,0.958,0.456,2728,0.641,"PPP3R2, NFAT5, PRKCQ, MALT1, PPP3R1, PPP3CA, PPP3CB, VAV2, MAPK12, MAPK3, MAP3K7, AKT2, AKT3, PIK3R3, SOS1, MAPK14, CBLB, MAPK13, CDC42, CHUK, NFKB1, FYN, HRAS, PAK5, PAK6, AKT1, CHP1, PAK4, PIK3CB, BCL10, RHOA, PTPN6",0.341035157335565,0.193141970481183,FALSE +"H1650","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.30281,0.926,0.541,1790,0.686,"UBE2L6, TRAF6, UBA7, FBXO2, KEAP1, WWP2, FBXO4, UBE3B, DDB2, HERC4, ITCH, WWP1, HUWE1, FZR1, SYVN1, NEDD4, MID1, SKP1, TRIM32, SKP2, CBLB",0.266802734893431,0.163675884293248,FALSE +"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.33149,0.986,0.445,5924,0.626,"BCAT2, IARS2, LARS2, BCAT1, PDHB, PDHA1, VARS2",0.351639989019068,0.20342566678957,FALSE +"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.30165,0.902,0.531,2929,0.701,"ABAT, ALDH7A1, ACAA1, HIBADH, ALDH3A2, BCAT2, OXCT1, ACAT2, HMGCS1, AUH, ACAD8, DLD, EHHADH, BCKDHB, MCCC2, HADH, HADHA, HADHB, ALDH9A1, ACADSB, MCCC1, MCEE",0.274905478918531,0.154281982033341,FALSE +"H1650","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.34902,1.08,0.314,1760,0.515,"KCNMA1, PRKCQ, PRKACB, ADCY6, ADCY5, PRKCD, ITPR2, GNAS, MYL6, MYH11, ADCY3, ADCY8, MAPK3, PRKCE, MYL9, PRKACA, PRKCA, PPP1R12B, GNAQ, ROCK1",0.503070351926785,0.288192770958809,FALSE +"H1650","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.50687,1.54,0.0745,2693,0.337,"PRKACB, ARHGDIB, ADCY6, RAB11A, GNAS, DYNC1LI2, ADCY3, RAB11B, DYNC1I2, DYNC1H1, PRKACA, STX4, RAB5B, RAB5C, DYNC2H1, DCTN1, RAB5A, VAMP2, DCTN4, DCTN6, DYNLL2",1.12784372725171,0.472370099128661,FALSE +"H1650","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.44319,1.37,0.134,2710,0.358,"HSPB1, PPP3R2, NFAT5, PPP3R1, PPP3CA, PPP3CB, PTK2, MAPKAPK3, MAPK12, MAPK3, AKT2, AKT3, PIK3R3, SPHK2, PXN, MAPK14, PRKCA, MAPK13, SRC, CDC42, SH2D2A, PLCG2, RAC1, HRAS, MAPKAPK2, AKT1, PLA2G12A, CHP1, PIK3CB",0.872895201635192,0.446116973356126,FALSE +"H1650","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.25989,0.806,0.696,2193,0.813,"PRKACB, ERO1A, KDELR3, TCIRG1, GNAS, ADCY3, TJP2, PRKACA, PRKCA, ATP6V1C2, ACTG1, PLCG2, ATP6V1C1",0.157390760389438,0.0899094544059319,FALSE +"H1650","Input","KEGG_VIRAL_MYOCARDITIS",0.46071,1.45,0.0917,1185,0.343,"CD40, ITGB2, CAV1, MYH14, MYH7B, MYH4, CD55, DAG1, CXADR, MYH11, MYH9",1.03763066432998,0.464705879957229,FALSE +"H1650","Input","KEGG_WNT_SIGNALING_PATHWAY",0.28828,0.91,0.53,1803,0.693,"CAMK2G, PPP3R2, CAMK2B, NFAT5, FZD2, PPP3R1, PRKACB, FZD1, PPP3CA, CTNNB1, PPP3CB, CAMK2D, APC, PPP2R5E, SMAD3, MAP3K7, PORCN, CREBBP, SKP1, EP300, PRKACA, PRKCA, PPP2R5A, ROCK1, VANGL1",0.275724130399211,0.159266765388193,FALSE +"H1975","Input","KEGG_ABC_TRANSPORTERS",0.3515,1.06,0.342,1220,0.596,"ABCG2, ABCA3, TAP1, ABCB8, ABCA1",0.465973893943865,0.224753740259764,FALSE +"H1975","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.36108,1.09,0.315,2283,0.587,"MYC, AKT1, ARAF, MAP2K2, RAF1, PIK3R2, STAT5A, RPS6KB2, PIK3CA, IKBKG, MAPK1, CHUK, IKBKB, RUNX1, TCF7L1, NFKB1, BRAF",0.501689446210399,0.231361898752386,FALSE +"H1975","Input","KEGG_ADHERENS_JUNCTION",0.18147,0.547,0.981,2134,1,"RAC2, SORBS1, WASF1, ACTN3, FER, VCL, ACTN1, MAP3K7, FYN, MAPK1, SMAD4, TGFBR1, TCF7L1",0.0083309926200515,0,FALSE +"H1975","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.31622,-0.969,0.447,8785,0.71,"PCK2, RXRB, PRKAB1, ACSL6, CPT1A, SLC2A1, ADIPOR2, ADIPOR1, PRKAA2",0.349692476868064,0.148741651280925,FALSE +"H1975","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.39596,1.2,0.238,1268,0.549,"GFPT2, ADSL, ASL, ASNS, ASS1, CPS1",0.623423042943488,0.260427655549908,FALSE +"H1975","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.25709,0.774,0.762,2963,0.837,"PRKCA, PRKCB, PIK3R2, NR3C2, PIK3CA, MAPK1, IRS1, PDPK1, IRS2, SFN, NEDD4L, INSR",0.1180450286604,0.07727454200674,FALSE +"H1975","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.62443,-1.9,0.0171,8351,0.246,"PLA2G12A, ACOX3, PLA2G2D, ACOX1, PLA2G4A, PLA2G2A",1.76700388960785,0.609064892896621,TRUE +"H1975","Input","KEGG_ALZHEIMERS_DISEASE",-0.22158,-0.685,0.863,7249,0.909,"APOE, UQCRQ, COX7A2, ATP5PO, NDUFA4, COX6B1, ADAM10, COX5B, BID, ATP5F1D, UQCRFS1, BAD, UQCRC2, COX5A, ATP5PF, NCSTN, COX7A2L, UQCRC1, NDUFA5, ATP5F1E, PLCB2, APP, CYC1, ATP5PD, ATP2A2, UQCRB, CASP7, PLCB4, SNCA, BACE2, MME, PLCB1",0.0639892042847904,0.0414361167780325,FALSE +"H1975","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.20376,0.609,0.953,7903,0.994,"LARS2, FARS2, HARS2, FARSB, FARSA, SEPSECS, CARS2, RARS2, TARS2, DARS2, MTFMT, YARS2, NARS2, VARS2, MARS2, PARS2, IARS2, EARS2, SARS2, WARS2, AARS2",0.0209070993616736,0.00261361560268669,FALSE +"H1975","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.42705,1.3,0.158,2528,0.609,"GFPT2, RENBP, UAP1, AMDHD2, GMPPA, UGDH, GMPPB, HK2, GNPDA1, GPI, NAGK, GNE, PGM2, CYB5R3, HK3, PGM3",0.801342913045577,0.215382707367125,FALSE +"H1975","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.48166,1.46,0.1,505,0.833,"NEFH, PRPH, PRPH2, TP53, NEFM, CCS",1,0.0793549985932124,FALSE +"H1975","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.15472,0.461,0.998,2208,0.998,"CD74, TAP1, LGMN, CTSB, CTSL, HSPA2",0.000869458712628891,0.000869458712628891,FALSE +"H1975","Input","KEGG_APOPTOSIS",0.47654,1.43,0.0954,2233,0.752,"TP53, IL1RAP, PRKACA, PRKAR1B, AKT1, CASP8, ENDOG, TRADD, PIK3R2, IRAK4, IRAK1, MYD88, TNFRSF10D, CAPN2, PIK3CA, IKBKG, PPP3CA, XIAP, CHUK, IKBKB, PRKAR1A, PPP3CB, IRAK2, PRKACB, PRKAR2A, FADD, ENDOD1, NFKB1",1.0204516252959,0.123782159408358,FALSE +"H1975","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.40931,-1.24,0.191,8863,0.444,"PLA2G2D, TBXAS1, ALOX5, CYP2J2, CYP4F3, AKR1C3, PLA2G4A, PTGS2, PLA2G2A",0.718966632752272,0.35261702988538,FALSE +"H1975","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34722,1.04,0.373,1902,0.59,"NOS3, MAOB, ASL, ARG1, ASS1, GATM, CPS1, CKB, MAOA, SMS, OAT, GLS, GLS2",0.428291168191312,0.229147988357856,FALSE +"H1975","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.32182,-0.966,0.448,9580,0.68,"ITGA1, CACNA2D1, ITGB8, PKP2, CDH2, SGCD",0.348721986001856,0.167491087293764,FALSE +"H1975","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.32282,-0.998,0.399,7529,0.67,"ALDH7A1, ALDH3A2, ALDH2",0.399027104313252,0.173925197299174,FALSE +"H1975","Input","KEGG_AXON_GUIDANCE",0.42478,1.28,0.188,1781,0.611,"RAC2, ABLIM3, SEMA3B, PAK5, PAK6, SRGAP1, DPYSL2, LIMK1, RGS3, EPHB2, SEMA7A, RASA1, PLXNA3, GNAI2, EPHB4, ABLIM1, NRP1, ROBO1, SRGAP2, SRGAP3, SEMA4C, PAK1, FYN, PPP3CA, MAPK1",0.72584215073632,0.213958789757446,FALSE +"H1975","Input","KEGG_BASAL_CELL_CARCINOMA",0.41379,1.25,0.176,919,0.544,"FZD2, TP53, WNT5B, DVL1, DVL2",0.75448733218585,0.26440110030182,FALSE +"H1975","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.18977,0.58,0.968,8043,1,"STON1, TAF11, GTF2E2, GTF2IRD1, GTF2E1, TAF1, TAF7, GTF2F1, TAF4, GTF2H3, GTF2A2, GTF2H4, TAF6L, GTF2H2, TAF2, TAF6, TBPL1, GTF2F2, TBP, TAF5, TAF5L, GTF2A1, TAF9, TAF9B, TAF10, GTF2B, GTF2I, TAF12, GTF2H1",0.0141246426916063,0,FALSE +"H1975","Input","KEGG_BASE_EXCISION_REPAIR",-0.43785,-1.34,0.15,6637,0.416,"POLB, PCNA, PARP1, PARP2, MBD4, POLE3, MPG, XRCC1, LIG1, UNG, TDG, FEN1, POLD1, HMGB1, POLD3, MUTYH, POLE, POLD2, APEX2, POLE2",0.823908740944319,0.380906669373257,FALSE +"H1975","Input","KEGG_BETA_ALANINE_METABOLISM",-0.2739,-0.849,0.611,7467,0.777,"ACADM, ALDH7A1, HADHA, ABAT, ALDH3A2, HIBCH, ALDH2",0.213958789757446,0.109578981199086,FALSE +"H1975","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.24323,0.736,0.799,1537,0.886,"ACOT4, HACD2, HACD1, ACAA1",0.0974532206860086,0.0525662781129492,FALSE +"H1975","Input","KEGG_BLADDER_CANCER",0.33074,1.01,0.391,2283,0.596,"TP53, MYC, THBS1, ARAF, TYMP, MAP2K2, RAF1, CDKN1A, MAPK1, VEGFA, DAPK3, CDK4, BRAF",0.407823242604133,0.224753740259764,FALSE +"H1975","Input","KEGG_BUTANOATE_METABOLISM",-0.49108,-1.48,0.089,7529,0.38,"ALDH7A1, HADH, HADHA, ACADS, OXCT1, ABAT, ALDH3A2, HMGCS1, L2HGDH, ACAT2, ALDH2, BDH1, ALDH5A1",1.05060999335509,0.42021640338319,FALSE +"H1975","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.37051,1.12,0.269,1904,0.589,"RAC2, CD79A, CARD11, CD81, VAV2, VAV1, AKT1, MALT1, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, PIK3CA, IKBKG, LYN, PPP3CA, MAPK1, CHUK, IKBKB, PPP3CB",0.570247719997592,0.229884705212898,FALSE +"H1975","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.40289,1.2,0.215,2506,0.549,"NOS3, TNNC1, MYLK, PRKACA, PRKCA, CACNA1A, F2R, ITPR1, GNA15, ADCY7, PHKA1, PRKCB, PLCG2, GNA11, PHKB, CACNA1F, PTK2B, ATP2B1, PPP3CA, PPP3CB, ATP2A3, PRKACB, PHKG2, ITPR3, ATP2B2, ATP2B4, PLCD1, PHKA2, GNAS, CAMK2G, GRIN1",0.667561540084395,0.260427655549908,FALSE +"H1975","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.31443,0.947,0.484,257,0.636,"MYH7, TNNC1, TPM4",0.315154638355588,0.196542884351586,FALSE +"H1975","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.327,0.988,0.427,1763,0.606,"VCAN, ICAM2, CD274, SDC4, ICAM1, CD40, CNTNAP1, CLDN4, CADM1, MPZ, CDH15, CDH3, PVR, CLDN16, CLDN6, SPN, CD276, CLDN3, SDC1, ALCAM",0.369572124974976,0.217527375833714,FALSE +"H1975","Input","KEGG_CELL_CYCLE",-0.37917,-1.15,0.248,7661,0.509,"ATR, ORC4, ANAPC7, ORC1, CDC25C, ORC2, CDC25B, CDC45, MCM2, MCM7, CDC26, RB1, RAD21, MCM4, MCM6, MCM3, ESPL1, DBF4, STAG1, TFDP2, PLK1, ORC3, ZBTB17, CDC7, E2F3, MAD2L1, TFDP1, MDM2, BUB1B, MAD2L2, CHEK1, TTK, BUB1, PTTG1, ORC6, TGFB1, CCNB2, WEE1, CDC20, SKP2, CCNA2, CDC14B",0.605548319173784,0.293282217663241,FALSE +"H1975","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.28638,0.865,0.633,2283,0.701,"RAC2, PRKACA, GNG10, VAV2, VAV1, AKT1, ADCY7, PRKCB, RAF1, PIK3R2, GNAI2, BCAR1, PRKCD, GNB4, PTK2B, GRK2, PIK3CA, IKBKG, PAK1, STAT2, LYN, GNG5, HCK, MAPK1, CHUK, IKBKB, FOXO3, PRKACB, ARRB1, NFKB1, CRK, BRAF",0.198596289982645,0.154281982033341,FALSE +"H1975","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.35431,1.07,0.346,2845,0.595,"TP53, MYC, AKT1, ARAF, MAP2K2, RAF1, PIK3R2, CDKN1B, STAT5A, BCR, CDKN1A, PIK3CA, IKBKG, MAPK1, CHUK, IKBKB, SMAD4, TGFBR1, CDK4, RUNX1, NFKB1, CRK, BRAF, CRKL, TGFB2, CBL, SOS2, CCND1",0.460923901207223,0.22548303427145,FALSE +"H1975","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.26691,-0.819,0.638,6745,0.802,"CLOCK, CSNK1E, BHLHE40",0.195179321278838,0.0958256317158365,FALSE +"H1975","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.34781,-1.06,0.34,6653,0.59,"MDH2, OGDH, OGDHL, IDH3G, SDHB, DLST, IDH3B, IDH3A, PCK2, DLAT, IDH2",0.468521082957745,0.229147988357856,FALSE +"H1975","Input","KEGG_COLORECTAL_CANCER",0.32619,0.987,0.421,2283,0.601,"RAC2, TP53, MYC, AKT1, ARAF, RAF1, PIK3R2, MAPK10, MAPK8, PIK3CA, APPL1, MAPK1, APC, SMAD4, TGFBR1, TCF7L1, BRAF",0.375717904164332,0.22112552799726,FALSE +"H1975","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.38026,1.15,0.242,868,0.575,"SERPINE1, PROS1, C4A, PLAU, F2R, TFPI, A2M, C3",0.616184634019569,0.24033215531037,FALSE +"H1975","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.38729,1.17,0.226,2745,0.56,"TAT, LDHA, CTH, SMS, LDHB, SDS, MPST, SRM, MTR, AHCY",0.645891560852599,0.2518119729938,FALSE +"H1975","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.31713,-0.966,0.45,8918,0.68,"IL1R1, TNFSF13B, LIF, TGFB1, IL6, TNFRSF21, INHBA, CXCR4, TNFRSF11B, CX3CL1, CXCL5, NGFR",0.346787486224656,0.167491087293764,FALSE +"H1975","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.25405,-0.772,0.719,9336,0.843,"TREX1, IL6, ZBP1",0.143271109617117,0.0741724253752577,FALSE +"H1975","Input","KEGG_DILATED_CARDIOMYOPATHY",0.40717,1.25,0.191,257,0.544,"MYH7, TNNC1, ITGB3, DES, PRKACA, ITGA5, TPM4",0.718966632752272,0.26440110030182,FALSE +"H1975","Input","KEGG_DNA_REPLICATION",-0.61634,-1.92,0.0224,7089,0.375,"RPA3, POLE3, MCM5, RNASEH2B, LIG1, RFC3, PRIM1, POLA1, MCM2, FEN1, POLD1, MCM7, POLD3, POLA2, RFC4, MCM4, MCM6, MCM3, POLE, POLD2, RNASEH2C, PRIM2, POLE2",1.64975198166584,0.425968732272281,FALSE +"H1975","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.15728,0.471,0.998,2797,1,"ETS1, MAPK1, SPIRE1, SOS2",0.000869458712628891,0,FALSE +"H1975","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.47746,1.42,0.112,895,0.733,"ALDH3B1, MAOB, GSTP1, GSTA5, GSTM2, CYP3A4, GSTZ1",0.950781977329818,0.134896025358872,FALSE +"H1975","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.48953,1.49,0.0718,1671,0.813,"UPP1, CDA, IMPDH1, CYP3A4, TYMP, UCKL1, DPYD, IMPDH2",1.1438755557577,0.0899094544059319,FALSE +"H1975","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.41838,1.3,0.158,580,0.609,"FN1, COL5A1, TNC, ITGB3, COL1A2, ITGA5, THBS2, CD44, SDC4, COL6A1, THBS1, COL1A1",0.801342913045577,0.215382707367125,FALSE +"H1975","Input","KEGG_ENDOCYTOSIS",0.31138,0.925,0.495,3371,0.633,"EHD2, SH3KBP1, ASAP3, F2R, EPN1, CHMP2A, RAB31, ITCH, IQSEC2, SH3GL1, RABEP1, EHD4, PSD3, DNM2, SMURF1, ASAP2, PLD2, STAM, ARFGAP1, ARFGAP3, IQSEC1, RBSN, GRK2, RAB11FIP5, PDCD6IP, GIT2, RAB5B, DNM1, CHMP3, ACAP2, DNAJC6, VPS37A, DNM1L, VPS4A, SH3GLB1, HSPA2, ARRB1, EEA1, AGAP1, PSD4, CHMP2B, PSD, RAB5A, SMURF2, CBL, ASAP1, RAB11FIP1, RAB11FIP2, WWP1, TSG101, PLD1, NEDD4L, STAM2, RAB22A, VPS4B, RAB5C, RNF41, GIT1, TRAF6, VPS25, ARF6, EPN3, EHD3",0.305394801066431,0.198596289982645,FALSE +"H1975","Input","KEGG_ENDOMETRIAL_CANCER",0.41013,1.23,0.224,2283,0.542,"TP53, MYC, PTEN, AKT1, ARAF, MAP2K2, RAF1, PIK3R2, PIK3CA, ILK, MAPK1, FOXO3, APC, TCF7L1, PDPK1, BRAF",0.649751981665837,0.266000713461613,FALSE +"H1975","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.35618,1.09,0.307,3667,0.587,"PLCG2, MAPK10, MAPK8, MAP2K4, IKBKG, PAK1, LYN, CHUK, IKBKB, ATP6V1C1, NFKB1, ATP6V1G1, ATP6V1D, ATP6V1E1, ATP6V1B2, TCIRG1, MAPK14, ATP6V1B1, MAPK9, GIT1, ATP6V1H, PLCG1, RELA, CASP3, ATP6V1F, TJP1, ADAM17, ATP6V1A",0.512861624522813,0.231361898752386,FALSE +"H1975","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.41338,1.27,0.183,2804,0.548,"PAK5, PAK6, PRKCA, MYC, AKT1, ARAF, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, CDKN1B, STAT5A, MAPK10, RPS6KB2, MAPK8, CDKN1A, MAP2K4, PIK3CA, PAK1, MAPK1, CRK, BRAF, ABL2, PAK3, CRKL, CAMK2G, AREG, CBL, CAMK2D, SOS2, PAK2",0.737548910269571,0.261219441515631,FALSE +"H1975","Input","KEGG_ETHER_LIPID_METABOLISM",-0.30959,-0.949,0.488,8863,0.696,"PLA2G2D, PAFAH1B3, PLA2G4A, PLA2G2A",0.311580177997289,0.157390760389438,FALSE +"H1975","Input","KEGG_FATTY_ACID_METABOLISM",-0.31974,-0.948,0.459,7467,0.682,"ACADM, ALDH7A1, HADH, HADHA, ACADS, ECI1, ALDH3A2, ACAT2, ACOX3, ACSL6, CPT1A, ACOX1, ALDH2, ACADL, ADH1C",0.338187314462739,0.166215625343521,FALSE +"H1975","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.36516,1.11,0.301,1781,0.597,"RAC2, PLA2G6, PRKCA, VAV2, VAV1, AKT1, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, MAPK10, PRKCD, MAPK8, MAP2K4, PIK3CA, FYN, LYN, MAPK1",0.521433504406157,0.224025668870631,FALSE +"H1975","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.42379,1.28,0.187,2241,0.611,"RAC2, PLA2G6, PRKCA, ASAP3, LIMK1, WASF1, VAV2, VAV1, AKT1, PLPP2, MYO10, DNM2, PRKCB, PLCG2, RAF1, PIK3R2, ASAP2, PLD2, PLPP1, PRKCD, RPS6KB2, PIK3CA, PAK1, DNM1, LYN, HCK, MAPK1, DNM1L, MARCKS, ARPC4, ARPC5L, CRK, ARPC1A",0.728158393463501,0.213958789757446,FALSE +"H1975","Input","KEGG_FOCAL_ADHESION",0.44046,1.33,0.147,1658,0.63,"FN1, COL5A1, TNC, ITGB3, RAC2, CAV2, MYLK, CAV1, PAK5, PAK6, PRKCA, COL1A2, ITGA5, THBS2, FLNA, MYL9, COL6A1, THBS1, ZYX, PARVA, VAV2, VAV1, PTEN, AKT1, COL1A1, TLN2, FLNC, ACTN3, MYL12A, PRKCB, RAF1, PIK3R2, ARHGAP5, BCAR1, MAPK10, TLN1, MAPK8, VCL, CAPN2, ACTN1, PIK3CA, ITGA3, PAK1, ILK, FYN",0.832682665251824,0.200659450546418,FALSE +"H1975","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.35669,-1.08,0.305,7275,0.591,"ALPI, ALPP, ALPL, GGH, DHFR",0.515700160653214,0.228412519118745,FALSE +"H1975","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.52992,1.62,0.0353,2937,1,"AKR1B1, ALDOB, ALDOC, FBP2, FBP1, PFKFB4, MTMR1, GMPPA, MTMR6, GMPPB, HK2, PFKP, SORD, HK3, PFKM, PHPT1, ALDOA",1.45222529461218,0,FALSE +"H1975","Input","KEGG_GALACTOSE_METABOLISM",0.31091,0.942,0.467,3748,0.631,"AKR1B1, HK2, B4GALT1, PFKP, PGM2, MGAM, HK3, PFKM, GAA, GLB1, GALK1, PFKL, UGP2, GALE",0.330683119433888,0.199970640755866,FALSE +"H1975","Input","KEGG_GAP_JUNCTION",0.35606,1.09,0.304,1189,0.587,"TUBA4A, PRKACA, PRKCA, GJA1, TUBB6, ITPR1, ADCY7, PRKCB, MAP2K2, RAF1, GNA11, GNAI2, TUBA3C",0.517126416391246,0.231361898752386,FALSE +"H1975","Input","KEGG_GLIOMA",0.39706,1.2,0.246,1471,0.549,"TP53, PRKCA, PTEN, AKT1, ARAF, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, CDKN1A, PIK3CA",0.609064892896621,0.260427655549908,FALSE +"H1975","Input","KEGG_GLUTATHIONE_METABOLISM",0.43351,1.34,0.137,1882,0.657,"ANPEP, GSTP1, GSTA5, GGT1, GSTM2, GPX4, GSS, GSTZ1, SMS, GGT7, RRM1, GPX3, G6PD",0.863279432843593,0.182434630440219,FALSE +"H1975","Input","KEGG_GLYCEROLIPID_METABOLISM",0.34322,1.04,0.37,1674,0.59,"AKR1B1, AGPAT4, MGLL, PLPP2, DGKA, PLPP1, CEL, DGKB, GPAT3, DGKQ, GPAM",0.431798275933005,0.229147988357856,FALSE +"H1975","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.31557,0.944,0.472,1674,0.634,"PLA2G6, AGPAT4, PLPP2, DGKA, PTDSS1, LPCAT1, MBOAT7, PLD2, PLPP1, DGKB, CHKB, GPAT3, CDS2, DGKQ, CHKA, GPAM",0.326058001365912,0.197910742118267,FALSE +"H1975","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.57847,1.71,0.0453,1465,1,"SARDH, MAOB, SHMT1, SRR, CTH, GATM, MAOA, PSAT1",1.34390179798717,0,FALSE +"H1975","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.32299,0.986,0.442,2937,0.595,"ALDH3B1, ALDOB, LDHA, ALDOC, GALM, PGK2, FBP2, ACSS1, FBP1, PGAM1, PGAM4, PGK1, PKM, LDHB, HK2, GPI, PFKP, PGM2, HK3, ALDH9A1, PFKM, ENO2, PKLR, ALDH1B1, ALDOA",0.354577730650908,0.22548303427145,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.42066,-1.26,0.168,8932,0.451,"CHSY3, XYLT1",0.774690718274137,0.345823458122039,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.46541,-1.45,0.0998,7497,0.368,"HS2ST1, GLCE, EXTL2, XYLT1",1.00086945871263,0.434152181326482,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.3595,-1.1,0.316,9017,0.574,"B4GAT1, B4GALT4, B3GNT2",0.500312917381596,0.241088107602027,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.23143,-0.716,0.831,7944,0.91,"HPSE, ARSB, GUSB, HEXA",0.080398976215889,0.0409586076789064,FALSE +"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.28895,0.858,0.627,4039,0.707,"B4GALNT1, ST3GAL2, GLB1, HEXB, SLC33A1, ST3GAL1",0.202732459169284,0.150580586203101,FALSE +"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.3233,0.977,0.433,526,0.589,"B3GALT5",0.363512103646635,0.229884705212898,FALSE +"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.42236,-1.3,0.153,7885,0.45,"B4GALT3, B3GNT3, B4GAT1, ST3GAL4, B4GALT4, B3GNT2",0.815308569182401,0.346787486224656,FALSE +"H1975","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.14942,-0.467,0.998,6278,1,"PIGU, PIGS, PIGX, PIGT, GPAA1, PIGK, PIGO",0.000869458712628891,0,FALSE +"H1975","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.309,0.94,0.516,2512,0.627,"MTHFD1, HYI, PGP",0.287350298372789,0.202732459169284,FALSE +"H1975","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.25085,0.761,0.759,1424,0.852,"PLA2G6, PRKACA, PRKCA, ITPR1, ADCY7, PRKCB, MAP2K2, MMP14, RAF1, GNA11, PLD2, MAPK10, PRKCD, MAPK8, CACNA1F, MAP2K4, PTK2B",0.11975822410452,0.0695604052332999,FALSE +"H1975","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.36442,1.1,0.296,1117,0.597,"PRKACA, WNT5B, FBXW11",0.528708288941061,0.224025668870631,FALSE +"H1975","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.4457,1.35,0.127,286,0.661,"ANPEP, ITGB3, ITGA5, CD44, CSF1",0.896196279044043,0.17979854051436,FALSE +"H1975","Input","KEGG_HISTIDINE_METABOLISM",0.38017,1.18,0.226,1308,0.564,"ALDH3B1, MAOB, HNMT, TRMT11, MAOA",0.645891560852599,0.248720896016658,FALSE +"H1975","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.5707,-1.73,0.0292,7933,0.343,"BRCA2, POLD1, POLD3, EME1, RAD52, POLD2, MUS81, RAD54B, MRE11, BLM, RAD51",1.53461714855158,0.464705879957229,FALSE +"H1975","Input","KEGG_HUNTINGTONS_DISEASE",-0.15189,-0.448,0.998,6482,0.998,"TBP, POLR2J, SOD1, BBC3, SIN3A, COX7B, CASP9, ATP5PB, ATP5F1C, UQCRH, VDAC1, NDUFB10, POLR2G, ATP5F1B, CREB1, SDHB, SP1, UQCRQ, HDAC2, COX7A2, ATP5PO, NDUFA4, POLR2D, COX6B1, RCOR1, SLC25A5, GRM5, COX5B, VDAC3, POLR2K, ATP5F1D, POLR2E, POLR2L, UQCRFS1, UQCRC2, POLR2C, COX5A, ATP5PF, COX7A2L, UQCRC1, NDUFA5, ATP5F1E, PLCB2, CYC1, ATP5PD, SLC25A4, POLR2I, SOD2, UQCRB, REST, POLR2F, PLCB4, PLCB1",0.000869458712628891,0.000869458712628891,FALSE +"H1975","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.3829,1.17,0.229,468,0.56,"MYH7, TNNC1, ITGB3, DES, ITGA5, PRKAB2, TPM4, ACE",0.640164517660112,0.2518119729938,FALSE +"H1975","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.23182,-0.71,0.833,8770,0.903,"ITPK1, ISYNA1, INPP1, PLCB4, INPP5B, PLCB1, ITPKA",0.0793549985932124,0.0443122496864942,FALSE +"H1975","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.39026,1.16,0.243,2488,0.567,"PYGL, PYGB, PRKACA, PRKAB2, SORBS1, PRKAR1B, AKT1, ARAF, PHKA1, PRKAG2, TRIP10, MAP2K2, FBP2, EIF4E2, RAF1, FBP1, PIK3R2, PHKB, MAPK10, RPS6KB2, MAPK8, RHEB, PIK3CA, ACACA, TSC1, TSC2, EXOC7, ACACB, MAPK1, IRS1, IKBKB, HK2, PRKAR1A, PRKACB, RAPGEF1, PRKAR2A, PDPK1, PHKG2, CRK, BRAF, PHKA2, IRS2, HK3, CRKL",0.614393726401688,0.246416941107093,FALSE +"H1975","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.63372,-1.9,0.0177,9030,0.246,"TNFSF13B, TGFB1, IL6, CXCR4",1.75202673363819,0.609064892896621,TRUE +"H1975","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.20607,0.634,0.932,1618,0.98,"MYC, STAT6, AKT1, OSMR, TYK2, PIK3R2, STAT5A, STAM, PIK3CA, LIFR, STAT2",0.0305840876460186,0.00877392430750515,FALSE +"H1975","Input","KEGG_LEISHMANIA_INFECTION",-0.23201,-0.694,0.834,8989,0.912,"TLR2, TGFB1, PTGS2, FOS",0.0788339493622613,0.0400051616715838,FALSE +"H1975","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.39867,1.22,0.221,1471,0.548,"RAC2, PRKCA, MSN, MYL9, ICAM1, VAV2, VAV1, CYBA, CLDN4, ACTN3, MYL12A, PRKCB, PLCG2, PIK3R2, ARHGAP5, GNAI2, BCAR1, CLDN16, CLDN6, VCL, ACTN1, PTK2B, PIK3CA",0.655607726314889,0.261219441515631,FALSE +"H1975","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.40122,-1.24,0.212,7529,0.444,"ALDH7A1, HADHA, ALDH3A2, YOD1, ALDH2",0.673664139071249,0.35261702988538,FALSE +"H1975","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.51809,-1.6,0.0729,8351,0.314,"PLA2G12A, PLA2G2D, CYP2J2, PLA2G4A, PLA2G2A",1.13727247168203,0.503070351926785,FALSE +"H1975","Input","KEGG_LONG_TERM_DEPRESSION",0.35499,1.07,0.34,1076,0.595,"PLA2G6, PRKCA, CACNA1A, ITPR1, ARAF, GNA13, PRKCB, MAP2K2, RAF1, GNA11, GNA12, GNAI2",0.468521082957745,0.22548303427145,FALSE +"H1975","Input","KEGG_LONG_TERM_POTENTIATION",0.42164,1.27,0.168,932,0.548,"PRKACA, PRKCA, RPS6KA6, ITPR1, RPS6KA3, RPS6KA2, ARAF, PRKCB, MAP2K2, RAF1",0.774690718274137,0.261219441515631,FALSE +"H1975","Input","KEGG_LYSINE_DEGRADATION",-0.48523,-1.53,0.0853,7368,0.373,"SETD1A, DLST, ASH1L, ALDH7A1, HADH, HADHA, SETD1B, DOT1L, EHMT1, ALDH3A2, EHMT2, ACAT2, SETDB2, NSD3, SUV39H2, SETDB1, AADAT, NSD1, KMT5A, ALDH2, SUV39H1, NSD2, AASS, BBOX1, TMLHE",1.06905096883248,0.428291168191312,FALSE +"H1975","Input","KEGG_LYSOSOME",0.32882,0.992,0.418,2438,0.614,"ACP5, GALC, AP3S1, CTSF, AP3D1, AP3M2, AP1M2, IGF2R, AP3B1, IDS, LIPA, AP1S2, AP3M1, CTSA, AP1M1, LGMN, AP1S3, CTSB, LAMP2, CD63, NPC2, NAGPA, CTSL, AP1S1, AP1B1, AP4E1, SMPD1, LAMP3, AP1G1, GALNS, GGA1, AP4B1",0.378823718224965,0.211831628858832,FALSE +"H1975","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.29461,0.885,0.569,2237,0.671,"RAC2, TP53, PLA2G6, PRKACA, PRKCA, MOS, CACNA1A, FLNA, RPS6KA6, RAPGEF2, RPS6KA3, MYC, HSPB1, RPS6KA2, AKT1, RASA1, PPM1B, FLNC, RRAS2, PTPN7, PRKCB, MAP2K2, DUSP9, RAF1, MAPT, GNA12, MAPKAPK3, TAB1, MAPK10, MAPK8, CACNA1F, MAP2K4, CD14, MAP3K7, IKBKG, MAP4K3, PAK1, MAPK7, PPP3CA, PPM1A, MAPK1, MAP3K5, CHUK, IKBKB, MAP3K4, PPP3CB, TAB2, PRKACB, TGFBR1, MAPK8IP3, HSPA2, ARRB1, NFKB1, CRK, TAOK3",0.244887733604929,0.173277479831008,FALSE +"H1975","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.72945,-2.26,0,8319,0.211,"HES1, PDX1, HNF1A, HNF4A, PAX6",Inf,0.675717544702307,TRUE +"H1975","Input","KEGG_MELANOGENESIS",0.34859,1.07,0.335,1076,0.595,"FZD2, PRKACA, PRKCA, MITF, WNT5B, ADCY7, DVL1, PRKCB, MAP2K2, DVL2, RAF1, GNAI2",0.474955192963155,0.22548303427145,FALSE +"H1975","Input","KEGG_MELANOMA",-0.33141,-1.01,0.374,9908,0.665,"FGF13, FGF2",0.42712839779952,0.177178354696895,FALSE +"H1975","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.38893,1.18,0.246,895,0.564,"ALDH3B1, GSTP1, GSTA5, CYP1B1, GSTM2, CYP3A4, GSTZ1",0.609064892896621,0.248720896016658,FALSE +"H1975","Input","KEGG_MISMATCH_REPAIR",-0.37846,-1.16,0.251,6634,0.528,"RFC2, PCNA, MSH3, RPA3, MSH6, MSH2, LIG1, RFC3, POLD1, POLD3, RFC4, POLD2, EXO1",0.600326278518962,0.277366077466188,FALSE +"H1975","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.45627,1.38,0.111,2440,0.754,"RPS6KA6, RPS6KA3, RPS6KA2, AKT1, CAB39, EIF4E2, PIK3R2, RICTOR, STRADA, RPS6KB2, RHEB, PIK3CA, TSC1, TSC2, MAPK1, EIF4B, VEGFA, PDPK1, BRAF, ULK1",0.954677021213343,0.122628654130226,FALSE +"H1975","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.52797,1.56,0.056,1904,1,"ICAM2, RAC2, PRKCA, ICAM1, MICA, VAV2, VAV1, ARAF, ULBP1, RAET1L, ULBP2, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, PRF1, TNFRSF10D, PTK2B, PIK3CA, PAK1, FYN, PPP3CA, MAPK1, ULBP3, PPP3CB",1.2518119729938,0,FALSE +"H1975","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.4103,1.24,0.194,818,0.536,"F2R, F2RL1, NR3C1",0.712198270069774,0.27083521030723,FALSE +"H1975","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.34476,1.03,0.368,2495,0.583,"TP53, RPS6KA6, RPS6KA3, RPS6KA2, RIPK2, AKT1, MAP2K2, PLCG2, RAF1, PIK3R2, YWHAH, IRAK4, MAPK10, PRKCD, IRAK1, MAPK8, PIK3CA, MAPK7, MAGED1, MAPK1, IRS1, MAP3K5, IKBKB, FOXO3, IRAK2, RAPGEF1, PDPK1, NFKB1, CRK, BRAF, IRS2, CRKL, CAMK2G",0.434152181326482,0.234331445240986,FALSE +"H1975","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.4539,1.36,0.118,1122,0.731,"NNMT, NAMPT, ENPP1, NT5C2, NT5E",0.928117992693875,0.13608262304214,FALSE +"H1975","Input","KEGG_NITROGEN_METABOLISM",0.34057,1.03,0.396,1268,0.583,"CA12, CA9, ASNS, CTH, CPS1",0.402304814074488,0.234331445240986,FALSE +"H1975","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.49777,1.52,0.0696,2233,0.977,"TRIP6, RIPK2, CASP8, PYDC1, TAB1, MAPK10, MAPK8, ERBIN, TAB3, MAP3K7, IKBKG, XIAP, MAPK1, CHUK, IKBKB, TAB2, NFKB1",1.15739076038944,0.0101054362812269,FALSE +"H1975","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.45163,-1.38,0.118,8146,0.407,"FEN1, LIG4, MRE11",0.928117992693875,0.39040559077478,FALSE +"H1975","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.30867,0.926,0.515,949,0.638,"TP53, PRKCA, AKT1, ARAF, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2",0.288192770958809,0.195179321278838,FALSE +"H1975","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.22824,0.695,0.871,1347,0.94,"DVL1, DVL2, DTX3L, JAG1",0.0599818449923368,0.0268721464003014,FALSE +"H1975","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.37218,-1.17,0.238,7879,0.53,"LIG1, RFC3, GTF2H1, POLD1, CUL4A, POLD3, RFC4, POLE, POLD2, ERCC1, POLE2, GTF2H5, DDB2",0.623423042943488,0.275724130399211,FALSE +"H1975","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.25682,-0.775,0.707,7008,0.853,"DPAGT1, GANAB, ALG9, MOGS, MAN1A2, B4GALT3, ALG8, MAN2A2, ALG6, MGAT5, ALG5, ALG13, ALG14, MGAT4A",0.150580586203101,0.069050968832477,FALSE +"H1975","Input","KEGG_OLFACTORY_TRANSDUCTION",0.35894,1.1,0.309,2730,0.597,"PRKACA, PRKACB, CAMK2G, CAMK2D",0.510041520575165,0.224025668870631,FALSE +"H1975","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.44693,-1.38,0.109,9163,0.407,"DHFR, TYMS, ALDH1L1",0.962573502059376,0.39040559077478,FALSE +"H1975","Input","KEGG_OOCYTE_MEIOSIS",0.22653,0.694,0.86,1904,0.933,"PRKACA, MOS, RPS6KA6, ITPR1, RPS6KA3, SMC1B, RPS6KA2, AR, ADCY7, YWHAH, FBXW11, PPP2R5E, PPP2R5B, SLK, PPP3CA, MAPK1, PPP2CB, PPP3CB",0.0655015487564323,0.0301183562535,FALSE +"H1975","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.43007,-1.29,0.158,7313,0.445,"GBA, MAN2B2, MANBA, HEXA, FUCA1",0.801342913045577,0.351639989019068,FALSE +"H1975","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.17496,-0.539,0.989,6631,1,"COX7B, ATP5ME, ATP5PB, ATP5F1C, UQCRH, ATP5MG, NDUFB10, ATP5F1B, COX11, SDHB, UQCRQ, COX7A2, ATP5PO, NDUFA4, COX6B1, COX5B, ATP5F1D, UQCRFS1, UQCRC2, ATP12A, COX5A, ATP5PF, COX7A2L, UQCRC1, NDUFA5, ATP5F1E, CYC1, ATP5PD, UQCRB, PPA2",0.0048037084028206,0,FALSE +"H1975","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.2724,0.81,0.694,1894,0.78,"GALNT12, GALNT6, GALNT13, GALNT7, GALNT10, GALNT16, GALNT17",0.158640529545145,0.10790539730952,FALSE +"H1975","Input","KEGG_P53_SIGNALING_PATHWAY",0.32705,0.999,0.406,586,0.608,"SERPINE1, TP53, STEAP3, THBS1, TP53I3, PTEN, CASP8",0.391473966422806,0.216096420727265,FALSE +"H1975","Input","KEGG_PANCREATIC_CANCER",0.34523,1.04,0.362,2364,0.59,"RAC2, TP53, AKT1, RALB, ARAF, RAF1, PIK3R2, MAPK10, MAPK8, PIK3CA, RALA, IKBKG, MAPK1, CHUK, IKBKB, VEGFA, SMAD4, TGFBR1, CDK4, NFKB1, BRAF, RALBP1",0.441291429466834,0.229147988357856,FALSE +"H1975","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.35781,1.12,0.282,2175,0.589,"ENPP1, PANK2, DPYD, PANK1",0.549750891680639,0.229884705212898,FALSE +"H1975","Input","KEGG_PARKINSONS_DISEASE",-0.27786,-0.864,0.583,6631,0.799,"COX7B, CASP9, ATP5PB, ATP5F1C, UQCRH, VDAC1, NDUFB10, UBE2J1, ATP5F1B, SDHB, UQCRQ, COX7A2, ATP5PO, NDUFA4, COX6B1, SLC25A5, COX5B, VDAC3, ATP5F1D, UQCRFS1, UQCRC2, COX5A, HTRA2, ATP5PF, COX7A2L, PARK7, UQCRC1, NDUFA5, ATP5F1E, CYC1, ATP5PD, SLC25A4, UBE2J2, UQCRB, UBE2G2, UCHL1, SNCA",0.234331445240986,0.0974532206860086,FALSE +"H1975","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.34842,1.06,0.31,3542,0.596,"LY96, TUBA4A, PRKCA, TUBB6, TUBA3C, CD14, FYN, ARHGEF2, ARPC4, ARPC5L, CTTN, TUBB4B, ARPC1A, ARPC2, TUBA1C, TUBB3, TUBB1, CTNNB1, CDH1, ROCK2, ARPC3, ARPC1B, YWHAQ, ABL1, ARPC5, TUBA1B",0.508638306165727,0.224753740259764,FALSE +"H1975","Input","KEGG_PATHWAYS_IN_CANCER",-0.31115,-0.938,0.467,9314,0.684,"TGFB1, AXIN2, LAMA5, IL6, SLC2A1, COL4A1, RET, WNT10A, RASSF5, TGFA, RAD51, MMP1, FZD1, SKP2, CEBPA, PML, BIRC5, FGFR2, PTGS2, FOS, LAMB4, LAMB1, MMP2, COL4A2, FGF13, FGF2",0.330683119433888,0.164943898279884,FALSE +"H1975","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.44533,1.35,0.123,2209,0.661,"AKR1B1, XYLB, UGDH, CRYL1",0.910094888560602,0.17979854051436,FALSE +"H1975","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.55606,1.64,0.0524,2962,1,"ALDOB, RBKS, ALDOC, FBP2, FBP1, PGLS, PRPS1, PRPS1L1, GPI, G6PD, PFKP, PGM2, PFKM, PRPS2, ALDOA, DERA",1.28066871301627,0,FALSE +"H1975","Input","KEGG_PEROXISOME",-0.29213,-0.915,0.517,8264,0.715,"PEX11A, PRDX5, ACOX3, PHYH, SOD2, ABCD3, PEX2, ACSL6, ACOX1, PEX14, HSD17B4, SLC27A2, IDH2, NUDT19, ECH1",0.286509456906058,0.145693958198919,FALSE +"H1975","Input","KEGG_PHENYLALANINE_METABOLISM",0.60139,1.8,0.0265,375,0.979,"ALDH3B1, MAOB, TAT, MIF",1.57675412606319,0.00921730819686218,FALSE +"H1975","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.3277,0.98,0.446,2600,0.591,"PRKCA, ITPR1, IMPA2, PIP4K2A, PTEN, PIP4K2C, DGKA, SYNJ2, PRKCB, PLCG2, PIK3R2, PI4KA, DGKB, CDS2, PIK3CA, DGKQ, INPP4A, INPP5E, INPP5A, ITPR3, PLCD1, CDIPT, PI4KB, PIK3C3, INPPL1, INPP5K",0.350665141287858,0.228412519118745,FALSE +"H1975","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.25598,-0.784,0.703,7977,0.853,"UROS, FECH, GUSB, MMAB, BLVRB, CP",0.153044674980176,0.069050968832477,FALSE +"H1975","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.33577,1.01,0.384,574,0.596,"CYP27A1, ANGPTL4, PLTP, ACSL4, SORBS1, ME1, PPARG",0.415668775632469,0.224753740259764,FALSE +"H1975","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.46509,1.41,0.0953,24,0.716,"CYP27A1",1.02090709936167,0.145086977692144,FALSE +"H1975","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.44325,1.35,0.136,653,0.661,"CD79A, CD40, ADA, TAP1",0.866461091629782,0.17979854051436,FALSE +"H1975","Input","KEGG_PRION_DISEASES",-0.28228,-0.862,0.617,9350,0.786,"IL6, NCAM1, C9",0.209714835966758,0.104577453960592,FALSE +"H1975","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.29922,0.913,0.525,1471,0.648,"PRKACA, MOS, RPS6KA6, RPS6KA3, RPS6KA2, AKT1, ARAF, ADCY7, RAF1, PIK3R2, GNAI2, MAPK10, MAPK8, PIK3CA",0.279840696594043,0.188424994129407,FALSE +"H1975","Input","KEGG_PROPANOATE_METABOLISM",-0.27114,-0.823,0.664,7467,0.811,"ACADM, ALDH6A1, ALDH7A1, HADHA, ABAT, ALDH3A2, ACAT2, HIBCH, ACSS3, ALDH2, MCEE",0.177831920631982,0.090979145788844,FALSE +"H1975","Input","KEGG_PROSTATE_CANCER",0.30764,0.931,0.514,2391,0.636,"GSTP1, TP53, PTEN, AKT1, ARAF, AR, MAP2K2, RAF1, PIK3R2, CDKN1B, CREB5, CDKN1A, PIK3CA, IKBKG, MAPK1, CHUK, IKBKB, TCF7L1, PDPK1, NFKB1, BRAF, CCNE1",0.289036881004724,0.196542884351586,FALSE +"H1975","Input","KEGG_PROTEASOME",0.33695,1.04,0.382,3414,0.59,"PSMB9, PSMB10, PSMF1, SEM1, PSMB8, PSME4, PSMB4, PSMD14, PSMD11, PSMD3, PSMD7, PSMD6, PSMD12, PSMD13",0.417936637088291,0.229147988357856,FALSE +"H1975","Input","KEGG_PROTEIN_EXPORT",-0.54391,-1.67,0.0476,7537,0.33,"HSPA5, SEC61A2, SRPRA, SPCS3, SEC11A, SPCS2, SRPRB, IMMP2L, SRP14, SPCS1, SRP9",1.32239304727951,0.481486060122112,FALSE +"H1975","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.58648,-1.8,0.0312,7805,0.307,"ATP1A4, ATP1A1, ATP1A3, PCK2, SLC4A4, ATP1B1, CA2, GLUD2",1.50584540598156,0.512861624522813,FALSE +"H1975","Input","KEGG_PURINE_METABOLISM",0.26498,0.815,0.694,1198,0.778,"PDE5A, PDE4A, PDE4D, PAPSS2, ADSL, NME7, PFAS, ENPP1, AMPD3, ADA, ENTPD3, NT5C2, IMPDH1, AMPD1, ADCY7, ADK, NT5E, NME4, GMPR",0.158640529545145,0.109020403010311,FALSE +"H1975","Input","KEGG_PYRIMIDINE_METABOLISM",0.21891,0.654,0.91,1128,0.968,"UPP1, CDA, NME7, ENTPD3, NT5C2, TYMP, NT5E, NME4",0.0409586076789064,0.0141246426916063,FALSE +"H1975","Input","KEGG_PYRUVATE_METABOLISM",0.29567,0.889,0.588,1756,0.671,"AKR1B1, ME1, LDHA, HAGHL, ACSS1, ACACA, PKM, LDHB, ACACB",0.230622673923862,0.173277479831008,FALSE +"H1975","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.36929,1.13,0.272,1675,0.602,"FN1, ITGB3, RAC2, MYLK, PAK5, PAK6, ITGA5, MOS, MSN, MYL9, DIAPH2, MYH9, LIMK1, F2R, WASF1, VAV2, PIP4K2A, VAV1, ARAF, ENAH, PIP4K2C, ACTN3, GNA13, RRAS2, MYL12A, MYH10, MAP2K2, RAF1, PIK3R2, GNA12, SSH3, BCAR1, VCL, ACTN1, CD14, PIK3CA, ITGA3, PAK1, ARHGEF4, SSH2",0.565431095965801,0.220403508742175,FALSE +"H1975","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.38118,-1.15,0.252,9894,0.509,"PRKAA2",0.598599459218456,0.293282217663241,FALSE +"H1975","Input","KEGG_RENAL_CELL_CARCINOMA",0.33092,1.01,0.402,3029,0.596,"PAK5, PAK6, AKT1, ARAF, ETS1, MAP2K2, RAF1, PIK3R2, FLCN, PIK3CA, PAK1, MAPK1, VEGFA, RAPGEF1, CRK, BRAF, PAK3, CRKL, TGFB2, SOS2, PAK2, VHL, EGLN1",0.39577394691553,0.224753740259764,FALSE +"H1975","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.67973,2.05,0.00921,518,0.4,"ANPEP, CPA3, ACE, THOP1",2.03574036980315,0.397940008672038,FALSE +"H1975","Input","KEGG_RETINOL_METABOLISM",-0.65655,-1.98,0.0198,8808,0.436,"DHRS3, RDH10, DGAT1, ADH1C, DHRS9, ALDH1A1",1.70333480973847,0.360513510731414,FALSE +"H1975","Input","KEGG_RIBOFLAVIN_METABOLISM",0.69332,2.12,0.00367,1404,0.533,"ACP5, ENPP1, MTMR1, MTMR6",2.43533393574791,0.273272790973428,FALSE +"H1975","Input","KEGG_RIBOSOME",0.42905,1.27,0.171,4061,0.548,"RPS25, RPL37, RPL22L1, RPL29, RPS10, FAU, RPS7, RPS15, RPL27, RPS16, RPS26, RPS15A, RPL4, RPL37A, RPL21, RPS24, RPS8, RPL24, RSL24D1, RPL28, RPS9, RPL35A, RPS13, RPL14, UBA52, RPL35, RPL30, RPS21, RPL10, RPL36, RPS11, RPS5, RPS19, RPL8, RPL9, RPL3, RPL32, RPS3A, RPS3, RPL18A, RPL6, RPS18, RPL31, RPL26, RPS2, RPS20, RPS4X, RPL13A, RPL12, RPL5, RPL22, RPS23, RPL34, RPS28, RPL18, RPL15, RPLP0, RPL17, RPL11, RPL36A, RPL36AL, RPL23A, RPS27L, RPL7A, RPL7, RPL10A",0.767003889607846,0.261219441515631,FALSE +"H1975","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.48878,1.49,0.082,3047,0.813,"TBKBP1, CASP8, DHX58, TRADD, DDX58, IFIH1, MAPK10, ISG15, MAPK8, TRIM25, IRF7, MAVS, MAP3K7, IKBKG, OTUD5, ATG12, CHUK, IKBKB, FADD, NFKB1, RIPK1, TRAF3, MAPK14, CASP10, MAPK9, ATG5",1.08618614761628,0.0899094544059319,FALSE +"H1975","Input","KEGG_RNA_DEGRADATION",0.1707,0.514,0.997,7870,1,"EDC3, TTC37, PATL1, SKIV2L, PAPOLA, EDC4, CNOT4, XRN1, ZCCHC7, C1D, ENO2, DCP1A, MPHOSPH6, CNOT1, DCP1B, CNOT7, DDX6, ENO1, CNOT9, CNOT3, PARN, CNOT10, EXOSC7, EXOSC10, CNOT2, XRN2, MTREX, LSM1, DIS3, CNOT6L, HSPD1, HSPA9, LSM7, EXOSC3, CNOT6, WDR61, EXOSC2, CNOT8, EXOSC4, TENT4A, PAPOLG, LSM2, LSM6, LSM4, EXOSC1, EXOSC9, EXOSC5, EXOSC6, DCPS, ENO3, EXOSC8, LSM8, DCP2, LSM3",0.00130484168834428,0,FALSE +"H1975","Input","KEGG_RNA_POLYMERASE",-0.51817,-1.6,0.0615,5450,0.314,"POLR1A, POLR2H, POLR3G, POLR3H, POLR3C, POLR3GL, POLR2B, POLR1B, POLR3K, POLR2J, POLR3F, POLR2G, POLR2D, POLR1C, POLR1D, POLR2K, POLR2E, POLR2L, POLR2C, POLR1E, POLR2I, POLR2F",1.21112488422458,0.503070351926785,FALSE +"H1975","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.50335,1.5,0.0826,1497,0.943,"GGT1, PAPSS2, CTH, TRMT11, SCLY, GGT7",1.08301995267962,0.0254883072626717,FALSE +"H1975","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.35355,-1.07,0.323,8221,0.591,"PIK3R1, COL4A6, RB1, CKS1B, TRAF4, PIAS1, ITGA6, RXRB, E2F3, BCL2L1, LAMA5, COL4A1, SKP2, PTGS2, FHIT, LAMB4, LAMB1, COL4A2",0.490797477668897,0.228412519118745,FALSE +"H1975","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.30308,0.908,0.553,2934,0.65,"STX2, STX8, STX10, YKT6, VTI1B, SNAP29, STX3, BET1, VTI1A, STX4, VAMP7, STX12, USE1",0.257274868695302,0.187086643357144,FALSE +"H1975","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.28537,-0.861,0.575,9899,0.771,"SMPD3",0.24033215531037,0.112945621949043,FALSE +"H1975","Input","KEGG_SPLICEOSOME",-0.48324,-1.5,0.0773,5796,0.381,"SRSF6, CDC5L, SNRPD3, PPIL1, SRSF5, BUD31, SNRPE, PCBP1, SF3B1, PRPF8, EIF4A3, RBMX, DDX46, U2SURP, CRNKL1, LSM7, EFTUD2, HNRNPK, DDX5, RBM17, SRSF10, PRPF6, SRSF8, XAB2, SNRPB, CDC40, SF3A2, SNRNP200, HSPA8, SF3A1, SRSF2, LSM2, U2AF1, LSM6, DHX8, SNRNP70, SART1, LSM4, DDX42, TCERG1, DDX39B, SRSF7, TXNL4A, ACIN1, SRSF1, AQR, ALYREF, PQBP1, ISY1, DHX15, TRA2B, CCDC12, USP39, PRPF19, U2AF2, SF3B3, SF3B5, PRPF40B, SNRPG, SF3B4, WBP11, SF3B2, LSM8, MAGOHB, LSM3, PPIH, ZMAT2, PHF5A, SF3A3, BCAS2, HNRNPA1, SNRNP40, PRPF18, PRPF38A, THOC3, RBM8A, PPIE, SNU13, CWC15, HNRNPC, SNRPC, SNRNP27, SYF2, DDX23, HSPA1L, PUF60, SLU7, SNRPF, TRA2A, SRSF3, HNRNPA3, SRSF4, PRPF38B, SRSF9",1.11182050608168,0.419075024324381,FALSE +"H1975","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.50195,1.53,0.0718,2472,1,"PGM2L1, PYGL, PYGB, ENPP1, GBE1, UGDH, HK2, GPI, PGM2, MGAM, HK3",1.1438755557577,0,FALSE +"H1975","Input","KEGG_STEROID_BIOSYNTHESIS",-0.55301,-1.67,0.0438,8363,0.33,"SQLE, SOAT2, CYP27B1, DHCR24, MSMO1, FDFT1, HSD17B7, DHCR7, CYP51A1, TM7SF2",1.3585258894959,0.481486060122112,FALSE +"H1975","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.44592,-1.36,0.117,9071,0.411,"HSD17B7, AKR1D1, AKR1C3, AKR1C1, HSD11B2, HSD17B2",0.931814138253838,0.386158178123931,FALSE +"H1975","Input","KEGG_SULFUR_METABOLISM",-0.47961,-1.47,0.0964,9330,0.367,"SUOX, SULT1A1",1.01592296609717,0.435333935747911,FALSE +"H1975","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.4798,1.44,0.104,1782,0.829,"C4A, CD40, ACTN3, C3, ACTN1, C1R, TRIM21",0.98296666070122,0.0814454694497265,FALSE +"H1975","Input","KEGG_TASTE_TRANSDUCTION",0.42289,1.27,0.176,209,0.548,"PRKACA, CACNA1A",0.75448733218585,0.261219441515631,FALSE +"H1975","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.54759,-1.66,0.0522,7326,0.307,"PDSS1, MVK, HMGCS1, ACAT2, IDI1, DHDDS, HMGCR",1.28232949699774,0.512861624522813,FALSE +"H1975","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.30038,0.903,0.547,2687,0.652,"THBS2, MYC, AMH, THBS1, SMURF1, RPS6KB2, RBL2, ZFYVE16, E2F4, MAPK1, PPP2CB, SMAD4, TGFBR1, ACVR1, E2F5, SMAD1, SMURF2, TGFB2",0.262012673666569,0.18575240426808,FALSE +"H1975","Input","KEGG_THYROID_CANCER",0.42462,1.27,0.191,3100,0.548,"TP53, MYC, PPARG, MAP2K2, NCOA4, MAPK1, TCF7L1, BRAF, RXRG, PAX8, TPM3, CCND1, CTNNB1, CDH1, TFG",0.718966632752272,0.261219441515631,FALSE +"H1975","Input","KEGG_TIGHT_JUNCTION",0.32384,0.984,0.445,1251,0.591,"MYH7, PRKCA, MYH11, MYL9, MYH9, PTEN, AKT1, PRKCH, LLGL1, CLDN4, ACTN3, RRAS2, MYL12A, MYH10, EPB41L2, PRKCB, GNAI2, CASK, PRKCD, CLDN16, CLDN6, EPB41L1, TJP2",0.351639989019068,0.228412519118745,FALSE +"H1975","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.3736,1.12,0.285,2278,0.589,"LY96, IRF5, CD40, AKT1, CASP8, MAP2K2, PIK3R2, IRAK4, TAB1, MAPK10, IRAK1, MYD88, MAPK8, IRF7, MAP2K4, CD14, PIK3CA, MAP3K7, IKBKG, TOLLIP, MAPK1, CHUK, IKBKB, TAB2, FADD, NFKB1, LBP",0.54515513999149,0.229884705212898,FALSE +"H1975","Input","KEGG_TRYPTOPHAN_METABOLISM",0.40515,1.24,0.205,1308,0.536,"MAOB, CYP1B1, KYNU, GCDH, EHHADH, MAOA",0.688246138944246,0.27083521030723,FALSE +"H1975","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.45913,1.37,0.121,2992,0.741,"CACNA1A, PIK3R2, MAPK10, PRKCD, MAPK8, PIK3CA, PKM, MAPK1, IRS1, IKBKB, HK2, IRS2, HK3, ABCC8, PKLR, MTOR, INSR, MAPK9",0.91721462968355,0.130181792020672,FALSE +"H1975","Input","KEGG_TYROSINE_METABOLISM",0.45094,1.33,0.166,1308,0.63,"ALDH3B1, MAOB, TAT, MIF, GSTZ1, TRMT11, MAOA",0.779891911959945,0.200659450546418,FALSE +"H1975","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.35193,1.05,0.364,3051,0.606,"PAK5, PAK6, CARD11, VAV2, VAV1, AKT1, MALT1, MAP2K2, RAF1, PIK3R2, PIK3CA, MAP3K7, IKBKG, PAK1, FYN, PPP3CA, MAPK1, CHUK, IKBKB, PPP3CB, CDK4, PDPK1, NFKB1, PAK3, NFATC3, CBL, SOS2, PAK2, MAPK14, BCL10, MAPK9, NFAT5",0.438898616350944,0.217527375833714,FALSE +"H1975","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.21391,0.655,0.912,1755,0.976,"UBA7, ITCH, UBE2O, CUL4B, UBE3C, HUWE1, UBA6, CUL7, KEAP1, MGRN1, SMURF1, FBXW11, HERC1, UBE2M, HERC4, WWP2, STUB1, UBA1, ERCC8, BIRC6, FBXW8, XIAP",0.0400051616715838,0.0105501823333082,FALSE +"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.25119,-0.765,0.749,8873,0.84,"BCAT1",0.125518182300534,0.0757207139381184,FALSE +"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.42544,-1.28,0.184,7467,0.441,"ACADM, ALDH6A1, ALDH7A1, HADH, HADHA, ACADS, OXCT1, ABAT, ALDH3A2, HMGCS1, ACAT2, HIBCH, BCAT1, ALDH2, DBT, AUH, MCEE",0.735182176990464,0.355561410532161,FALSE +"H1975","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.43447,1.31,0.15,1381,0.651,"CALD1, MYLK, PLA2G6, PRKACA, PRKCA, MYH11, MYL9, ITPR1, PRKCH, ARAF, ADCY7, GNA13, MYL6, PRKCB, MAP2K2, RAF1, GNA11, GNA12, PRKCD, MYL6B, CACNA1F",0.823908740944319,0.186419011431808,FALSE +"H1975","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.41656,1.26,0.196,2604,0.552,"PRKACA, DYNC1I2, DYNC1H1, DYNC1LI2, DCTN1, DYNC1LI1, DYNC2LI1, CREB5, DCTN2, RAB5B, DCTN4, DCTN5, DYNC2H1, PRKACB, GNAS, STX4, RAB5A",0.707743928643524,0.258060922270801,FALSE +"H1975","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.43332,1.3,0.174,1074,0.609,"NOS3, RAC2, PLA2G6, PRKCA, HSPB1, AKT1, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, MAPKAPK3",0.7594507517174,0.215382707367125,FALSE +"H1975","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.34744,1.03,0.358,2785,0.583,"PRKACA, PRKCA, KDELR1, PRKCB, PLCG2, TJP2, PRKACB, ATP6V1C1, ATP6V1G1, GNAS, ATP6V1D, ATP6V1E1, ATP6V1B2, TCIRG1",0.446116973356126,0.234331445240986,FALSE +"H1975","Input","KEGG_VIRAL_MYOCARDITIS",0.47521,1.43,0.101,825,0.752,"MYH7, RAC2, CAV1, MYH11, MYH9, ICAM1, CD40, CASP8, MYH10",0.995678626217357,0.123782159408358,FALSE +"H1975","Input","KEGG_WNT_SIGNALING_PATHWAY",0.32988,0.989,0.435,2201,0.612,"RAC2, FZD2, TP53, PRKACA, PRKCA, PRICKLE1, MYC, WNT5B, DVL1, PRKCB, DVL2, FBXW11, MAPK10, PPP2R5E, MAPK8, DAAM1, MAP3K7, PPP2R5B, PPP3CA, PPP2CB, PPP3CB, APC, SMAD4, PRKACB, TCF7L1, PPP2R5C",0.361510743045363,0.213248577854439,FALSE +"H2009","Input","KEGG_ABC_TRANSPORTERS",0.32322,1.09,0.298,1760,0.498,"ABCG2, ABCD1, ABCC1, ABCA1, ABCC3",0.525783735923745,0.302770657240282,FALSE +"H2009","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.46475,-1.51,0.0914,7134,0.344,"RPS6KB1, MTOR, PIK3CB, MAP2K2, IKBKG, STAT5A, NFKB1, SOS1, RPS6KB2, PIK3R2, MAPK1, ARAF, RELA, AKT1, BRAF, MAPK3, PIK3CA, PIK3R1, AKT2, CEBPA, IKBKB, EIF4EBP1, RAF1, CCND1",1.03905380426617,0.46344155742847,FALSE +"H2009","Input","KEGG_ADHERENS_JUNCTION",0.26174,0.875,0.581,1714,0.657,"RAC2, CTNNB1, CDH1, CTNND1, CTNNA1, CTNNA2, LMO7, NECTIN4, TJP1, NECTIN1, ACTN4, BAIAP2, MET, AFDN, SSX2IP, ERBB2, IGF1R, SORBS1, PTPRJ, YES1, NECTIN2",0.235823867609669,0.182434630440219,FALSE +"H2009","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.49211,-1.57,0.0657,6982,0.332,"ACSL5, MAPK10, ACACB, MTOR, NFKBIB, IKBKG, PRKCQ, NFKB1, STK11, PRKAG2, TRAF2, PRKAB2, CPT1A, PCK2, MAPK8, PRKAB1, NFKBIE, RELA, AKT1, CAMKK2, PTPN11, PRKAA1, AKT2, PRKAG1, IKBKB",1.18243463044022,0.478861916295964,FALSE +"H2009","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.41557,-1.3,0.157,8405,0.373,"CAD, ADSL, ASL, NIT2, ASNS, CPS1, ASS1",0.804100347590766,0.428291168191312,FALSE +"H2009","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.24436,-0.773,0.719,6160,0.84,"IRS2, INSR, PRKCA, HSD11B2, PRKCB, PIK3CB, PIK3R2, MAPK1, NEDD4L, MAPK3, PIK3CA, PIK3R1",0.143271109617117,0.0757207139381184,FALSE +"H2009","Input","KEGG_ALZHEIMERS_DISEASE",-0.1856,-0.612,0.958,6977,0.971,"CDK5, ATP5PB, CAPN2, NDUFAB1, CASP9, COX6C, CASP8, CASP3, MAPK1, BACE2, ATP2A3, APAF1, IDE, FADD, GAPDH, APBB1, MAPK3, MME, CAPN1, GSK3B, PLCB4, CASP7, PLCB2",0.0186344909214556,0.0127807700919951,FALSE +"H2009","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.23689,-0.765,0.739,5956,0.837,"NARS2, FARS2, SARS2, EARS2, WARS2, MTFMT, FARSB, VARS2, FARSA, SEPSECS",0.131355561605174,0.07727454200674,FALSE +"H2009","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.6384,-2.05,0.00699,6681,0.374,"NANS, GFPT2, GMPPA, UGP2, GCK, CYB5R1, GNE, HK3, NAGK, GALE, PGM2, GALK1, PGM1, GFPT1, GALK2, PMM2, GMDS, MPI, PGM3, PMM1, GNPDA2, GMPPB, GALT, UAP1, FPGT, GNPNAT1, GNPDA1, GPI, AMDHD2",2.15552282425432,0.42712839779952,FALSE +"H2009","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.25587,-0.821,0.66,7014,0.779,"CCS, CASP9, MAPK14, MAPK12, CASP1, CASP3, NEFM, PRPH, PRPH2, APAF1, BAX, SOD1, MAP2K3",0.180456064458131,0.108462542327436,FALSE +"H2009","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.2992,0.992,0.408,2758,0.534,"CTSS, CTSL, CD74, RFXAP, RFXANK, CTSB, CALR, HSPA5, CREB1, RFX5, TAPBP, PSME3, NFYB, HSPA1L, IFI30, PDIA3",0.38933983691012,0.272458742971444,FALSE +"H2009","Input","KEGG_APOPTOSIS",-0.33497,-1.07,0.311,7026,0.482,"CAPN2, IRAK4, PIK3CB, CASP9, CASP6, IKBKG, NFKB1, BIRC2, CASP8, CASP3, TRAF2, PIK3R2, APAF1, IL1A, MYD88, RIPK1, BAX, RELA, AKT1, FADD, DFFB, PIK3CA, CAPN1, PIK3R1, AKT2, CASP7, IKBKB",0.507239610973163,0.31695296176115,FALSE +"H2009","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.31385,1.02,0.388,356,0.541,"GPX1, PLA2G12A, GGT5",0.411168274405793,0.266802734893431,FALSE +"H2009","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.25409,0.847,0.572,575,0.684,"GLUD2, GATM, ARG1, ALDH1B1, OAT, MAOA, PYCR1",0.242603971206976,0.164943898279884,FALSE +"H2009","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.7275,2.34,0,765,0.226,"ITGB6, ITGB4, ITGA2B, DSC2, GJA1, ITGA6, DSG2, PKP2, ITGA3, CTNNB1, LMNA, ITGA4, ITGB8, CTNNA1, CTNNA2, ITGA5, ITGA2, ITGAV, ACTN4",Inf,0.645891560852599,TRUE +"H2009","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.56676,1.82,0.0312,2597,0.186,"ALDH1B1, ALDH2, UGDH, ALDH7A1, ALDH3A2",1.50584540598156,0.730487055782084,TRUE +"H2009","Input","KEGG_AXON_GUIDANCE",0.23453,0.798,0.705,1058,0.747,"RAC2, SEMA4B, EFNB2, EPHA1, SEMA4D, EPHA2, HRAS, ROBO1, EPHB2, KRAS, NRAS, MET, PLXNB2, SEMA7A",0.151810883008601,0.126679398184601,FALSE +"H2009","Input","KEGG_BASAL_CELL_CARCINOMA",0.32696,1.08,0.312,2067,0.502,"TP53, CTNNB1, FZD6, DVL1, WNT5B, FZD7, APC",0.505845405981557,0.299296282854981,FALSE +"H2009","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.15908,0.526,0.99,6214,1,"TAF12, GTF2H1, TAF4, TAF11, TAF5, GTF2I, GTF2B, GTF2H2, TAF5L, TAF6, TAF9, TAF10, GTF2F2, TAF1, GTF2H3, TAF2, GTF2E2, GTF2H4, GTF2F1, TAF7, TAF6L, GTF2E1, GTF2A2, TAF9B, TBP, GTF2A1",0.00436480540245009,0,FALSE +"H2009","Input","KEGG_BASE_EXCISION_REPAIR",-0.25731,-0.826,0.645,5421,0.779,"POLE4, UNG, PARP1, POLE2, POLL, MUTYH, POLE, FEN1, PARP4, MPG, NTHL1, NEIL2, SMUG1, HMGB1, APEX1",0.190440285364732,0.108462542327436,FALSE +"H2009","Input","KEGG_BETA_ALANINE_METABOLISM",0.40571,1.32,0.143,2236,0.351,"ACADM, ALDH1B1, ECHS1, HADHA, ALDH2, SMS, ALDH7A1",0.844663962534938,0.454692883534176,FALSE +"H2009","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.46174,1.51,0.0791,1789,0.261,"FADS2, ACAA1, ACOX1, PECR, HADHA, ELOVL6, ELOVL5, FADS1",1.10182351650232,0.583359492661719,FALSE +"H2009","Input","KEGG_BLADDER_CANCER",0.33547,1.11,0.29,1410,0.492,"TP53, MMP1, CDH1, VEGFA, CDKN2A, HRAS, KRAS, NRAS, CXCL8, ERBB2, VEGFC, MYC",0.537602002101044,0.30803489723264,FALSE +"H2009","Input","KEGG_BUTANOATE_METABOLISM",0.44758,1.5,0.0806,2315,0.237,"ALDH1B1, OXCT1, ACAT1, ECHS1, HADH, HADHA, PDHA1, PDHB, ALDH2, ALDH7A1, HMGCL",1.09366495819491,0.625251653989896,FALSE +"H2009","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.34974,-1.1,0.303,6569,0.466,"BTK, BCL10, VAV3, PPP3CC, PTPN6, PIK3AP1, MAP2K1, PRKCB, PIK3CB, NFKBIB, PLCG2, MAP2K2, IKBKG, NFKB1, SOS1, NFATC2, PIK3R2, MAPK1, VAV2, NFKBIE, RELA, AKT1, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, MALT1, IKBKB, RAF1",0.518557371497695,0.33161408331,FALSE +"H2009","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.19421,-0.621,0.932,7972,0.972,"PHKG2, ATP2A3, PHKB, SLC8A1, PDGFRA, PDGFRB, PPID, P2RX4, PLCG1, PLCB4, PLCB2",0.0305840876460186,0.0123337350737254,FALSE +"H2009","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.34627,1.12,0.287,1871,0.502,"TNNC1, ATP1A2, SLC9A6, ATP1B1, SLC9A1, UQCRH, CACNA2D1, UQCRB, UQCRFS1",0.542118103266008,0.299296282854981,FALSE +"H2009","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.57772,1.93,0.0205,843,0.235,"CDH15, CDH3, CNTN1, ITGB2, CD274, CLDN7, ITGA6, F11R, SDC4, ALCAM, CDH1, ITGA4, ITGB8, NLGN2, CD276, ITGAV, CD58, CD99, NECTIN1, ICAM2, PVR, ICAM1",1.68824613894425,0.628932137728264,TRUE +"H2009","Input","KEGG_CELL_CYCLE",-0.22933,-0.745,0.788,7610,0.847,"CCND3, TFDP2, CDK1, ABL1, YWHAQ, YWHAG, BUB1B, CDKN1A, SMAD2, TGFB3, ORC6, CDK6, GSK3B, PTTG1, CDKN1B, CDKN2C, CCND1, RB1",0.103473782510445,0.0721165896692931,FALSE +"H2009","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.4488,-1.47,0.0777,7050,0.362,"PRKCB, ROCK1, PXN, PIK3CB, NFKBIB, PTK2B, IKBKG, CRKL, NFKB1, SOS1, GNAI1, PTK2, PIK3R2, MAPK1, VAV2, GSK3A, CRK, ROCK2, FOXO3, PRKCZ, ADCY5, RELA, PREX1, AKT1, BRAF, GRK2, MAPK3, ADCY6, PIK3CA, CCL13, CCL20, GSK3B, PIK3R1, AKT2, PLCB4, STAT2, IKBKB, ELMO1, CSK, PLCB2, RAF1, CXCR4, WAS",1.10957898119909,0.441291429466834,FALSE +"H2009","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.44086,-1.41,0.124,7329,0.344,"MAP2K2, IKBKG, CRKL, STAT5A, NFKB1, SOS1, ABL1, PIK3R2, MAPK1, CRK, ARAF, CDKN1A, RELA, CBL, AKT1, BRAF, TGFB3, MAPK3, PTPN11, PIK3CA, CDK6, PIK3R1, AKT2, CBLB, IKBKB, CDKN1B, GAB2, RAF1, CCND1, RB1",0.906578314837765,0.46344155742847,FALSE +"H2009","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.65024,2.12,0.00676,1274,0.156,"BHLHE41, BHLHE40, CLOCK",2.17005330405836,0.806875401645538,TRUE +"H2009","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.30027,0.988,0.404,3184,0.53,"SDHA, SDHB, IDH3A, PDHA1, PDHB, SUCLG2, SUCLG1, DLST, MDH2, ACO2, IDH3G, FH, PC, DLD, IDH3B, SDHD",0.393618634889395,0.275724130399211,FALSE +"H2009","Input","KEGG_COLORECTAL_CANCER",-0.29448,-0.934,0.514,6980,0.623,"MAP2K1, APPL1, MAPK10, PIK3CB, CASP9, CASP3, PIK3R2, MAPK1, MAPK8, ARAF, SMAD2, BAX, AKT1, BRAF, TGFB3, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, RAF1, CCND1",0.289036881004724,0.20551195334083,FALSE +"H2009","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.56122,1.84,0.0353,587,0.193,"PLAT, F3, SERPINA1, PLAU, THBD, MBL2, CFI, PLAUR, TFPI, CD55, PROS1",1.45222529461218,0.714442690992226,TRUE +"H2009","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.42514,-1.34,0.159,6006,0.359,"AHCYL1, AHCYL2, LDHB, TAT, MPST, MAT2A, CTH, ADI1, MTR, MAT1A, ENOPH1, SDS, LDHA, AHCY, CDO1, CBS, SRM",0.798602875679548,0.444905551421681,FALSE +"H2009","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.28406,0.951,0.487,2322,0.55,"LIFR, OSMR, TNFRSF1A, VEGFA, TNFSF9, IL13RA1, EPO, IL1R1, LTBR, MET, IL1RAP, TGFB2, CXCL8, VEGFC, TNFRSF10B, PDGFC, TNFRSF12A, TNFRSF10A, ACVR1, TNFSF13B, IL10RB, IL25, CD40",0.312471038785366,0.259637310505756,FALSE +"H2009","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.38272,-1.24,0.209,7218,0.416,"NFKBIB, IKBKG, NFKB1, CASP1, IRF3, IL18, DDX58, RIPK1, TBK1, RELA, PYCARD, IKBKB",0.679853713888946,0.380906669373257,FALSE +"H2009","Input","KEGG_DILATED_CARDIOMYOPATHY",0.53846,1.77,0.037,1330,0.188,"ITGB6, TNNC1, ITGB4, ITGA2B, ITGA6, ITGA3, LMNA, ITGA4, ITGB8, ITGA5, ITGA2, ITGAV, TTN, SGCB, TGFB2, CACNA2D1, DAG1",1.431798275933,0.72584215073632,TRUE +"H2009","Input","KEGG_DNA_REPLICATION",0.30351,0.995,0.406,3899,0.539,"POLA2, MCM3, POLD4, RFC4, SSBP1, RFC1, RFC2, RNASEH2A, RPA3, MCM4, RFC3, RFC5, MCM7, POLD3, MCM2, POLE3, POLA1, PRIM2, RPA2, PCNA, MCM6, POLD2, MCM5, RPA1, LIG1",0.391473966422806,0.268411234813261,FALSE +"H2009","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.3217,1.06,0.327,866,0.511,"NOTCH3, ETV6, KRAS",0.485452247339714,0.291579099865287,FALSE +"H2009","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.43435,-1.41,0.119,8535,0.344,"ALDH3A1, GSTZ1, GSTO1, GSTP1, GSTM3, ADH5",0.924453038607469,0.46344155742847,FALSE +"H2009","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.42153,-1.38,0.139,6255,0.333,"GUSB, UCK2, UCK1, TK1, TK2, IMPDH1, GMPS, UPP1, NAT1, DPYD, XDH, HPRT1, IMPDH2, UMPS, TPMT, ITPA",0.856985199745905,0.47755576649368,FALSE +"H2009","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.64879,2.15,0.00926,772,0.181,"ITGB6, LAMC2, COL6A1, TNC, ITGB4, ITGA2B, LAMB3, ITGA6, ITGA3, SDC4, ITGA4, ITGB8, LAMA3, LAMA4, ITGA5, ITGA2, LAMB1, ITGAV, COL6A6, CD47",2.03338901331807,0.742321425130815,TRUE +"H2009","Input","KEGG_ENDOCYTOSIS",-0.37891,-1.21,0.23,6772,0.416,"EHD4, SMAP2, VPS37C, SH3GLB2, PARD6G, CLTC, SH3GLB1, PARD6B, CHMP6, F2R, VPS36, RABEP1, ASAP1, DNM3, VPS4A, EHD2, MVB12A, PDCD6IP, ASAP2, VTA1, DNM2, SH3GL1, USP8, CHMP4A, CHMP4B, VPS28, LDLRAP1, PRKCZ, NEDD4L, VPS37A, VPS4B, ACAP2, PDGFRA, TSG101, NEDD4, CBL, SNF8, PRKCI, ARFGAP2, EHD1, SMAP1, GRK2, FGFR2, CHMP5, IQSEC1, EHD3, TRAF6, CHMP2A, VPS25, ARAP2, CBLB, ARAP1, ACAP3, CXCR4, ARFGAP1, ARFGAP3",0.638272163982407,0.380906669373257,FALSE +"H2009","Input","KEGG_ENDOMETRIAL_CANCER",-0.30712,-0.998,0.418,7206,0.572,"PIK3CB, CASP9, MAP2K2, SOS1, PTEN, PIK3R2, MAPK1, FOXO3, ARAF, AKT1, BRAF, ILK, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, RAF1, CCND1",0.378823718224965,0.242603971206976,FALSE +"H2009","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.35331,-1.13,0.262,7031,0.459,"MAPK10, ATP6V1E1, ATP6V1G1, PLCG2, IKBKG, NFKB1, MAPK14, MAPK12, CASP3, ATP6V1H, MAPK8, MAP2K4, ATP6V1B2, ATP6V1B1, ATP6V1A, ATP6V1C1, RELA, PTPN11, JAM3, PLCG1, IKBKB, CSK",0.581698708680255,0.338187314462739,FALSE +"H2009","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.41731,-1.33,0.128,6980,0.363,"MAP2K1, PAK3, MAPK10, PRKCB, RPS6KB1, MTOR, CAMK2B, PIK3CB, PAK2, PLCG2, MAP2K2, NCK1, CRKL, STAT5A, SOS1, RPS6KB2, MAP2K7, PTK2, ABL1, PIK3R2, MAPK1, MAPK8, MAP2K4, CRK, ARAF, CDKN1A, CBL, AKT1, BRAF, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, PLCG1, CBLB, CDKN1B, EIF4EBP1, RAF1",0.892790030352132,0.440093374963888,FALSE +"H2009","Input","KEGG_ETHER_LIPID_METABOLISM",0.58448,1.89,0.0208,795,0.202,"LPCAT1, PLPP2, PLA2G12A, CHPT1, PLPP3, LPCAT2, AGPS",1.68193666503724,0.694648630553376,TRUE +"H2009","Input","KEGG_FATTY_ACID_METABOLISM",0.49933,1.62,0.0523,1776,0.226,"ACADM, ALDH1B1, ACAA1, ACOX1, ACADVL, CPT2, ACAT1, ECHS1, HADHB, HADH, HADHA, ACSL4, ACADSB, ECI2, ACSL3, ALDH2",1.28149831113273,0.645891560852599,FALSE +"H2009","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.34406,-1.13,0.29,6980,0.459,"MAP2K1, MAPK10, PRKCB, PIK3CB, PLCG2, MAP2K2, MAPK14, MAPK12, SOS1, MAP2K7, PIK3R2, MAPK1, VAV2, MAPK8, MAP2K4, AKT1, MAPK3, PIK3CA, PIK3R1, AKT2, PLCG1, MAP2K3, GAB2, RAF1",0.537602002101044,0.338187314462739,FALSE +"H2009","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.33471,-1.1,0.306,6267,0.466,"ARPC2, PRKCA, PAK1, ARPC4, DNM1L, PIP4K2B, ARPC1A, VAV3, CFL1, WASL, MAP2K1, PRKCB, RPS6KB1, PIK3CB, PLCG2, AMPH, CRKL, ASAP1, LIMK2, DNM3, RPS6KB2, ASAP2, DNM2, PIK3R2, MAPK1, VAV2, CRK, AKT1, MAPK3, PIK3CA, PIK3R1, AKT2, PLCG1, GAB2, RAF1, WAS",0.51427857351842,0.33161408331,FALSE +"H2009","Input","KEGG_FOCAL_ADHESION",0.33848,1.1,0.318,765,0.495,"ITGB6, LAMC2, RAC2, COL6A1, TNC, ITGB4, ITGA2B, LAMB3, ITGA6, ITGA3, CAV2, CTNNB1, VEGFA, ITGA4, ITGB8, LAMA3, LAMA4, PIK3R3, ITGA5, FLNB, ITGA2, HRAS, LAMB1, ITGAV, COL6A6, JUN, ACTN4",0.497572880015567,0.305394801066431,FALSE +"H2009","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.54975,-1.76,0.0243,5955,0.376,"QDPR, PTS, SPR, DHFR",1.61439372640169,0.424812155072339,FALSE +"H2009","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.52604,-1.73,0.032,7189,0.349,"HK3, TPI1, ALDOA, SORD, KHK, PMM2, GMDS, MPI, PMM1, PHPT1, PFKFB3, GMPPB, PFKP, MTMR2, MTMR6, FPGT, PFKM, PFKL",1.49485002168009,0.45717457304082,FALSE +"H2009","Input","KEGG_GALACTOSE_METABOLISM",-0.48625,-1.6,0.0545,6911,0.331,"UGP2, GCK, HK3, GALE, PGM2, GALK1, PGM1, GALK2, PFKP, GALT, PFKM, PFKL",1.26360349772336,0.480172006224281,FALSE +"H2009","Input","KEGG_GAP_JUNCTION",-0.45665,-1.45,0.105,7537,0.339,"SOS1, GNAI1, CDK1, TUBB4B, MAPK1, MAPK7, ADCY5, PDGFRA, PDGFRB, TUBA1C, TUBB1, TUBB3, MAP2K5, MAPK3, TUBB, TUBB6, ADCY6, TUBA3C, TUBA1B, TUBB2A, TUBAL3, PLCB4, PLCB2, RAF1, TUBB2B",0.978810700930062,0.469800301796918,FALSE +"H2009","Input","KEGG_GLIOMA",-0.39128,-1.25,0.189,6980,0.419,"MAP2K1, PRKCB, MTOR, CAMK2B, PIK3CB, PLCG2, MAP2K2, SOS1, PTEN, PIK3R2, MAPK1, ARAF, CDKN1A, PDGFRA, PDGFRB, AKT1, BRAF, MAPK3, PIK3CA, CDK6, PIK3R1, AKT2, PLCG1, RAF1, CCND1, RB1",0.723538195826756,0.377785977033705,FALSE +"H2009","Input","KEGG_GLUTATHIONE_METABOLISM",-0.44793,-1.47,0.0836,8007,0.362,"RRM2B, GCLC, OPLAH, PGD, GGCT, GSTZ1, GSTO1, GSTP1, RRM2, GSTM3, SRM, LAP3, RRM1",1.07779372256098,0.441291429466834,FALSE +"H2009","Input","KEGG_GLYCEROLIPID_METABOLISM",0.30294,1,0.395,483,0.542,"ALDH1B1, PLPP2, DGKE, PLPP3, GPAT3, GLA",0.40340290437354,0.266000713461613,FALSE +"H2009","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.32367,1.11,0.27,380,0.492,"PEMT, LPCAT1, PLPP2, DGKE, PLA2G12A, CHPT1, PLPP3, GPAT3",0.568636235841013,0.30803489723264,FALSE +"H2009","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.36317,1.19,0.204,713,0.426,"PIPOX, GATM, MAOA, BHMT",0.690369832574101,0.370590400897281,FALSE +"H2009","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.44311,-1.41,0.112,6930,0.344,"GCK, BPGM, PKM, HK3, TPI1, PGM2, ALDOA, PGM1, ENO1, LDHA, PCK2, PGAM1, PGAM4, ENO3, PKLR, ACSS2, PGK1, GAPDH, ALDH3A1, PFKP, GPI, PFKM, AKR1A1, ADH5, PFKL",0.950781977329818,0.46344155742847,FALSE +"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.3152,1.03,0.368,2826,0.536,"CHST11, CHST3, CHST12, XYLT2, DSE, CHST7",0.434152181326482,0.27083521030723,FALSE +"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.4217,1.35,0.152,2292,0.343,"HS6ST1, EXTL2, HS6ST2, XYLT2",0.818156412055227,0.464705879957229,FALSE +"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.40924,1.34,0.147,455,0.343,"B4GALT3, B4GALT1",0.832682665251824,0.464705879957229,FALSE +"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.25099,-0.827,0.669,8293,0.785,"HGSNAT, HYAL1",0.174573882232177,0.105130343254747,FALSE +"H2009","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.77325,-2.45,0.00347,8777,0.127,"ST3GAL2, B4GALNT1",2.45967052520913,0.896196279044043,TRUE +"H2009","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.5863,1.93,0.0186,483,0.235,"B3GALNT1, GLA",1.73048705578208,0.628932137728264,TRUE +"H2009","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.67762,2.25,0.00688,944,0.174,"B3GNT3, B4GALT3, B4GALT1, ST3GAL4",2.16241156176449,0.7594507517174,TRUE +"H2009","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.51447,-1.64,0.0627,5557,0.338,"PIGT, PIGK, GPAA1, PIGO, PIGH, PIGM, PIGQ, PIGU",1.20273245916928,0.471083299722345,FALSE +"H2009","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.36586,-1.18,0.256,6932,0.442,"PGP, GRHPR, MDH1, HYI, ACO1, MTHFD1",0.59176003468815,0.354577730650908,FALSE +"H2009","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.37235,-1.22,0.21,5995,0.419,"ITPR2, CDC42, PRKCD, GNAS, PRKACA, PRKCA, MAP3K3, MAPK9, MAP3K2, ATF4, PLCB3, MAP2K1, MAPK10, PRKCB, CAMK2B, PTK2B, MAP2K2, MAPK14, MAPK12, SOS1, MAP2K7, MAPK1, MAPK8, MAP2K4, MAPK7, MAP3K4, ADCY5, MAPK3, ADCY6, PLCB4, MAP2K3, PLCB2, RAF1",0.677780705266081,0.377785977033705,FALSE +"H2009","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.4298,-1.4,0.127,8848,0.338,"GSK3B, GLI3",0.896196279044043,0.471083299722345,FALSE +"H2009","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.56575,1.85,0.0207,819,0.206,"ITGA2B, ITGA6, ITGA3, ITGA4, CD55, ITGA5, ITGA2, EPO, IL1R1",1.68402965454308,0.686132779630847,TRUE +"H2009","Input","KEGG_HISTIDINE_METABOLISM",0.24155,0.793,0.681,473,0.744,"ALDH1B1, HNMT, MAOA",0.166852888087215,0.128427064454121,FALSE +"H2009","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.35613,1.19,0.196,3718,0.426,"EME1, RAD51, POLD4, SSBP1, MUS81, RPA3, TOP3A, NBN, POLD3, BRCA2, RAD54L, RPA2, TOP3B, POLD2",0.707743928643524,0.370590400897281,FALSE +"H2009","Input","KEGG_HUNTINGTONS_DISEASE",0.16114,0.548,0.99,2692,1,"TP53, GPX1, SDHA, RCOR1, POLR2D, NDUFA8, POLR2L, UQCRH, SDHB, POLR2I, SIN3A, POLR2K, CREB5, NDUFS6, POLR2G, UQCRB, CREB1, POLR2J, CLTA, UQCRFS1, NDUFA7, POLR2C, NDUFB1, NDUFA2, NDUFV2, POLR2F, TAF4, UQCRC1, DLG4, VDAC1, POLR2E, NDUFS8, IFT57, NDUFS4, NDUFS5, EP300, HIP1, CLTB, NDUFV3, NDUFB10, NDUFB8, VDAC2, GNAQ, AP2A1",0.00436480540245009,0,FALSE +"H2009","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.48698,1.57,0.0673,1330,0.225,"ITGB6, TNNC1, ITGB4, ITGA2B, ITGA6, ITGA3, LMNA, ITGA4, ITGB8, ITGA5, ITGA2, ITGAV, TTN, SGCB, TGFB2, CACNA2D1, DAG1",1.17198493577602,0.647817481888638,FALSE +"H2009","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.51927,-1.65,0.0407,6581,0.347,"PIP4K2B, PI4KB, CDIPT, INPP4A, PLCB3, IMPA2, PIK3CB, MINPP1, TPI1, PLCG2, INPP5B, PTEN, SYNJ1, PIK3C2B, OCRL, PIK3CA, IMPA1, ITPK1, ISYNA1, INPPL1, PIK3C3, PLCG1, PLCB4, INPP1, PLCB2",1.39040559077478,0.459670525209126,FALSE +"H2009","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.42533,-1.38,0.135,6930,0.333,"GCK, MAP2K1, MAPK10, PHKA1, TSC1, ACACB, RPS6KB1, RPS6, MTOR, HK3, RAPGEF1, PIK3CB, MAP2K2, CRKL, MKNK2, SOS1, RPS6KB2, PRKAG2, PRKAB2, PIK3R2, MAPK1, PCK2, MAPK8, CRK, PHKG2, PRKAB1, ARAF, PRKCZ, PHKB, MKNK1, GYS1, PKLR, CBL, AKT1, BRAF, PRKCI, MAPK3, PPP1R3D, PRKAA1, PIK3CA, TSC2, GSK3B, PIK3R1, AKT2, PRKAG1, SOCS2, CBLB, IKBKB, FOXO1, EIF4EBP1, RAF1",0.869666231504994,0.47755576649368,FALSE +"H2009","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.38142,-1.23,0.212,8592,0.421,"ICOSLG, CXCR4",0.673664139071249,0.375717904164332,FALSE +"H2009","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.34591,-1.08,0.324,8325,0.481,"CBL, AKT1, PTPN11, PIK3CA, PIK3R1, STAT6, AKT2, SOCS2, CBLB, STAT2, PIAS4, CCND1, SPRY4",0.489454989793388,0.317854923626168,FALSE +"H2009","Input","KEGG_LEISHMANIA_INFECTION",-0.30183,-0.948,0.458,6703,0.614,"STAT1, PTPN6, MAP3K7, PRKCB, IRAK4, C3, NFKBIB, NFKB1, MAPK14, MAPK12, MAPK1, IL1A, MYD88, RELA, TGFB3, MAPK3, TAB2, TRAF6",0.339134521996131,0.211831628858832,FALSE +"H2009","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.29643,0.968,0.44,958,0.542,"ITGB2, RAC2, CLDN7, F11R, CTNNB1, SIPA1, CTNND1, ITGA4, CTNNA1, CTNNA2, PIK3R3, CD99, ACTN4, ICAM1, PIK3CD",0.356547323513813,0.266000713461613,FALSE +"H2009","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.37952,1.24,0.21,2597,0.397,"ALDH1B1, ECHS1, HADHA, ALDH2, ALDH7A1, ALDH3A2",0.677780705266081,0.401209493236885,FALSE +"H2009","Input","KEGG_LONG_TERM_DEPRESSION",-0.27573,-0.882,0.58,6833,0.7,"PLCB3, PPP2CA, MAP2K1, PRKCB, GUCY1A1, MAP2K2, GNAI1, PPP2R1B, MAPK1, GNA12, ARAF, BRAF, MAPK3, PPP2CB, PLCB4, GNA13, PLCB2, RAF1",0.236572006437063,0.154901959985743,FALSE +"H2009","Input","KEGG_LONG_TERM_POTENTIATION",-0.29808,-0.952,0.484,6292,0.614,"PRKACA, PRKCA, ATF4, PPP3CC, PLCB3, MAP2K1, PRKCB, CAMK2B, MAP2K2, MAPK1, ARAF, BRAF, MAPK3, PLCB4, PLCB2, RAF1",0.315154638355588,0.211831628858832,FALSE +"H2009","Input","KEGG_LYSINE_DEGRADATION",0.4429,1.5,0.0874,2236,0.237,"PIPOX, ALDH1B1, NSD2, ACAT1, ECHS1, DOT1L, PLOD2, EHMT1, HADH, HADHA, ASH1L, ALDH2, SETD2, AASS, DLST, SUV39H1, ALDH7A1",1.0584885673656,0.625251653989896,FALSE +"H2009","Input","KEGG_LYSOSOME",-0.20063,-0.627,0.913,7680,0.975,"SMPD1, ATP6V1H, AP3M2, CLN3, MANBA, GALC, AP3B1, AP1M1, HGSNAT, HYAL1, AP3M1, AP3S2, AP4E1, AP4M1, AP3S1, AP3D1, CTSG, CLN5",0.039529222465701,0.0109953843014632,FALSE +"H2009","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.3404,-1.08,0.325,7329,0.481,"MAP2K2, IKBKG, CRKL, NFKB1, HSPB1, MAPK14, MAPK12, MKNK2, SOS1, MAP2K7, CASP3, MAP4K2, TRAF2, RAPGEF2, NFATC2, MAP3K20, MAPK1, MAPK8, GNA12, MAP2K4, CRK, MAPK7, MAP3K4, IL1A, MKNK1, PDGFRA, MAPKAPK2, RELA, PDGFRB, RASA2, AKT1, BRAF, TGFB3, MAP2K5, MAPK3, FGFR2, PPM1A, DUSP3, MEF2C, NLK, NFKB2, TAB2, STK4, TRAF6, AKT2, STMN1, IKBKB, PPP5C, MAP2K3, FGFR1, RAF1",0.488116639021126,0.317854923626168,FALSE +"H2009","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.44743,-1.45,0.107,6930,0.339,"GCK, IAPP, PKLR, MNX1",0.97061622231479,0.469800301796918,FALSE +"H2009","Input","KEGG_MELANOGENESIS",-0.25611,-0.815,0.669,6744,0.782,"MITF, PLCB3, MAP2K1, PRKCB, CAMK2B, DCT, MAP2K2, DVL3, GNAI1, MAPK1, ADCY5, MAPK3, ADCY6, GSK3B, PLCB4, PLCB2, RAF1",0.174573882232177,0.106793246940152,FALSE +"H2009","Input","KEGG_MELANOMA",-0.3888,-1.26,0.171,7715,0.415,"PTEN, PIK3R2, MAPK1, ARAF, CDKN1A, PDGFRA, PDGFRB, AKT1, BRAF, MAPK3, PIK3CA, CDK6, PIK3R1, AKT2, FGFR1, RAF1, CCND1, RB1",0.767003889607846,0.381951903287907,FALSE +"H2009","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.52225,-1.68,0.0432,7659,0.385,"AKR1C1, AKR1C3, GSTT2, ALDH3A1, GSTZ1, GSTO1, GSTP1, GSTM3, ADH5",1.36451625318509,0.414539270491499,FALSE +"H2009","Input","KEGG_MISMATCH_REPAIR",0.55276,1.81,0.0352,3899,0.177,"POLD4, RFC4, SSBP1, RFC1, RFC2, MSH6, RPA3, MSH2, RFC3, MLH1, RFC5, PMS2, POLD3, RPA2, PCNA, POLD2, RPA1, LIG1",1.45345733652187,0.752026733638193,TRUE +"H2009","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.53238,-1.73,0.0479,7054,0.349,"TSC1, RPS6KB1, RPS6, MTOR, PIK3CB, RPS6KB2, STK11, PIK3R2, MAPK1, EIF4B, AKT1, BRAF, MAPK3, PRKAA1, PIK3CA, CAB39L, TSC2, STRADA, PIK3R1, AKT2, EIF4EBP1",1.31966448658544,0.45717457304082,FALSE +"H2009","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.35859,1.16,0.226,958,0.456,"ITGB2, RAC2, RAET1L, ULBP2, ULBP3, MICA, MICB, PIK3R3, HRAS, ICAM2, ICAM1, KRAS, NRAS, PIK3CD",0.645891560852599,0.341035157335565,FALSE +"H2009","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.41258,-1.32,0.162,5764,0.358,"HTR2B, NR3C1, F2, PLG, TACR1, CHRNE, PRSS1, F2R, HCRTR1, TSPO, P2RX4, CTSG",0.790484985457369,0.446116973356126,FALSE +"H2009","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.4355,-1.38,0.139,6980,0.333,"MAP2K1, YWHAE, MAPK10, IRAK4, CAMK2B, RAPGEF1, PIK3CB, NFKBIB, PLCG2, MAP2K2, CRKL, NFKB1, YWHAB, MAPK14, MAPK12, SOS1, MAP2K7, RIPK2, ABL1, PIK3R2, MAPK1, YWHAQ, MAPK8, YWHAG, ARHGDIA, CRK, MAPK7, FOXO3, NFKBIE, MAPKAPK2, BAX, RELA, AKT1, BRAF, NGFR, MAP2K5, MAPK3, PTPN11, PIK3CA, TRAF6, GSK3B, PIK3R1, AKT2, PLCG1, IKBKB, CSK, RAF1",0.856985199745905,0.47755576649368,FALSE +"H2009","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.34527,-1.1,0.314,6958,0.466,"NT5C3A, NT5C2, NADSYN1, NT5C, PNP, NAMPT, NNMT, NMRK1",0.503070351926785,0.33161408331,FALSE +"H2009","Input","KEGG_NITROGEN_METABOLISM",-0.45186,-1.46,0.106,8377,0.363,"CA1, CA12, CA9, ASNS, CPS1, CA8",0.97469413473523,0.440093374963888,FALSE +"H2009","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.56179,-1.79,0.0249,6749,0.421,"MAP3K7, SUGT1, MAPK10, NFKBIB, IKBKG, TRIP6, NFKB1, MAPK14, BIRC2, MAPK12, CASP8, CASP1, RIPK2, MAPK1, MAPK8, HSP90AB1, CARD6, IL18, HSP90AA1, RELA, PYCARD, MAPK3, CCL13, TAB2, TRAF6, IKBKB",1.60380065290426,0.375717904164332,FALSE +"H2009","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.257,-0.801,0.643,8909,0.798,"NHEJ1",0.191789027075778,0.0979971086492706,FALSE +"H2009","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.34885,-1.1,0.279,6980,0.466,"MAP2K1, PRKCB, PIK3CB, CASP9, PLCG2, MAP2K2, SOS1, PIK3R2, MAPK1, FOXO3, ARAF, AKT1, BRAF, MAPK3, PIK3CA, CDK6, STK4, PIK3R1, AKT2, PLCG1, RAF1, CCND1, RB1",0.554395796726402,0.33161408331,FALSE +"H2009","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.38446,1.27,0.172,2904,0.384,"NOTCH3, DTX2, HES1, CTBP1, JAG1, DVL1, CTBP2, RBPJ, DTX3L, NUMB, EP300, NCOR2, SNW1, CREBBP",0.764471553092451,0.415668775632469,FALSE +"H2009","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.26599,0.878,0.555,3545,0.663,"ERCC5, ERCC8, GTF2H5, MNAT1, POLD4, RFC4, GTF2H1, RFC1, RFC2, RPA3, RFC3, RFC5, RBX1, RAD23B, POLD3, POLE3, CUL4A, GTF2H2, RPA2, PCNA",0.255707016877324,0.178486471595227,FALSE +"H2009","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.24801,0.831,0.633,2528,0.701,"B4GALT3, B4GALT1, TUSC3, ALG2, ALG10, ALG10B, MAN2A1, FUT8, MGAT2, MAN1A1, MOGS, MAN2A2",0.198596289982645,0.154281982033341,FALSE +"H2009","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.42598,-1.37,0.135,6177,0.336,"PRKG1, PRKACA, ARRB2, CAMK2B, CLCA2",0.869666231504994,0.473660722610156,FALSE +"H2009","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.51467,-1.66,0.061,8150,0.358,"TYMS, DHFR, ATIC, GART, MTHFD1, MTHFR",1.21467016498923,0.446116973356126,FALSE +"H2009","Input","KEGG_OOCYTE_MEIOSIS",-0.35419,-1.13,0.261,5425,0.459,"CCNB2, ANAPC4, PRKACB, ANAPC7, PKMYT1, PPP3CB, CDK2, MOS, PPP1CA, CDC25C, CDC23, RPS6KA1, FBXW11, ITPR2, YWHAH, ESPL1, CUL1, PRKACA, YWHAZ, PPP2R1A, MAD2L1, CCNB1, PPP3CC, PPP2CA, MAP2K1, YWHAE, PPP2R5C, CAMK2B, YWHAB, MAPK12, PPP2R1B, CDK1, FBXO5, MAPK1, PPP2R5B, YWHAQ, YWHAG, ADCY5, PPP2R5E, MAPK3, ADCY6, PPP2CB, STAG3, PPP2R5A, PPP2R5D, PTTG1",0.583359492661719,0.338187314462739,FALSE +"H2009","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.26005,0.857,0.592,301,0.678,"NEU1",0.22767829327708,0.168770306132937,FALSE +"H2009","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.087514,-0.281,1,5656,1,"ATP6V1G2, NDUFA6, NDUFC2, ATP6V0A1, NDUFB5, NDUFA9, COX7A2, ATP5F1A, NDUFA4, ATP6V0C, NDUFS7, ATP5F1C, ATP6V1C2, ATP6V1D, ATP5PB, ATP6V1E1, ATP6V1G1, NDUFAB1, ATP5MG, COX6C, ATP6V1H, ATP6V1B2, LHPP, ATP6V1B1, ATP6V1A, ATP6V1C1, PPA1",0,0,FALSE +"H2009","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.52575,1.71,0.0501,373,0.202,"GALNT3, GALNT6, GALNT12, GALNT13, GALNT15, GALNT7",1.30016227413275,0.694648630553376,FALSE +"H2009","Input","KEGG_P53_SIGNALING_PATHWAY",-0.36936,-1.17,0.246,7610,0.447,"CCND3, CASP8, CASP3, CDK1, PTEN, RRM2B, SIAH1, CDKN1A, APAF1, BAX, SESN2, DDB2, CDK6, TSC2, SERPINE1, RRM2, CCND1",0.609064892896621,0.349692476868064,FALSE +"H2009","Input","KEGG_PANCREATIC_CANCER",-0.27715,-0.878,0.576,7828,0.7,"PIK3R2, MAPK1, MAPK8, ARAF, SMAD2, RELA, AKT1, BRAF, TGFB3, MAPK3, PIK3CA, CDK6, PIK3R1, AKT2, IKBKB, RAF1, CCND1, RB1",0.239577516576788,0.154901959985743,FALSE +"H2009","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.62371,-1.99,0.015,7354,0.295,"PPCDC, PANK2, PANK4, DPYD, PPCS",1.82390874094432,0.530177984021837,FALSE +"H2009","Input","KEGG_PARKINSONS_DISEASE",0.13281,0.432,0.998,3435,1,"SDHA, UBE2J1, UBE2G2, NDUFA8, UQCRH, SDHB, HTRA2, NDUFS6, UBE2J2, UQCRB, UQCRFS1, NDUFA7, NDUFB1, NDUFA2, NDUFV2, UQCRC1, VDAC1, NDUFS8, NDUFS4, NDUFS5, NDUFV3, LRRK2, NDUFB10, NDUFB8, VDAC2, NDUFA5, NDUFS1, UQCRC2, NDUFA3, NDUFV1, NDUFA10, NDUFB9, SDHD, COX5A, SLC25A5, COX7A2L, NDUFS3, SNCA, SLC25A4",0.000869458712628891,0,FALSE +"H2009","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.50904,-1.63,0.0488,7773,0.332,"TUBB4B, ABL1, YWHAQ, ROCK2, TUBA1C, TUBB1, TUBB3, TUBB, TUBB6, TUBA3C, TUBA1B, TUBB2A, TUBAL3, TUBB2B, CLDN1, WAS",1.31158017799729,0.478861916295964,FALSE +"H2009","Input","KEGG_PATHWAYS_IN_CANCER",-0.22836,-0.742,0.788,7329,0.843,"MAP2K2, IKBKG, DVL3, CRKL, STAT5A, NFKB1, BIRC2, HGF, SOS1, PTK2, CASP8, CASP3, TRAF2, PTEN, ABL1, PIK3R2, PIAS2, MAPK1, MAPK8, CRK, HSP90AB1, EGLN1, ARAF, CDKN1A, CUL2, SMAD2, PDGFRA, HSP90AA1, BAX, RELA, PDGFRB, CBL, AKT1, BRAF, FADD, TGFB3, MAPK3, FGFR2, PIK3CA, NFKB2, TFG, CDK6, STK4, TRAF6, GSK3B, PIK3R1, GSTP1, DAPK1, AKT2, PLCG1, CEBPA, CBLB, IKBKB, CDKN1B, FOXO1, PIAS4, FGFR1, COL4A1, RAF1, CCND1, RB1, GLI3",0.103473782510445,0.0741724253752577,FALSE +"H2009","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.48909,-1.62,0.0611,5337,0.325,"AKR1B1, UGT2B11, UGT2B4, DCXR, GUSB, UGP2, RPE, XYLB, CRYL1",1.21395878975745,0.488116639021126,FALSE +"H2009","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.57749,-1.83,0.0256,7160,0.41,"PRPS2, PGM2, ALDOA, RBKS, PGM1, PRPS1, PRPS1L1, RPE, PGLS, DERA, TALDO1, PGD, PFKP, GPI, PFKM, PFKL",1.59176003468815,0.387216143280265,FALSE +"H2009","Input","KEGG_PEROXISOME",0.30176,0.982,0.411,2320,0.53,"PIPOX, ACAA1, SLC25A17, ACOX1, PEX2, AGPS, PECR, PEX6, ABCD1, PEX26, ACSL4, PEX1, PEX13, ECI2, SCP2, ACSL3, FAR1, CROT, GSTK1, HSD17B4, HACL1, HMGCL, ACOT8",0.386158178123931,0.275724130399211,FALSE +"H2009","Input","KEGG_PHENYLALANINE_METABOLISM",-0.33871,-1.07,0.328,6402,0.482,"TAT, MAOB, DDC, MIF, PRDX6, NAA80, ALDH3A1",0.484126156288321,0.31695296176115,FALSE +"H2009","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.44934,-1.44,0.088,6581,0.34,"PIP4K2B, PI4KB, CDIPT, INPP4A, PLCB3, IMPA2, PRKCB, DGKZ, PIK3CB, DGKA, PLCG2, INPP5B, PTEN, PIK3R2, DGKB, SYNJ1, PIK3C2B, OCRL, PIK3CA, IMPA1, ITPK1, PIK3R1, INPPL1, PIK3C3, PLCG1, PLCB4, INPP1, DGKH, PLCB2",1.05551732784983,0.468521082957745,FALSE +"H2009","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.29433,-0.934,0.482,7805,0.623,"BLVRB, CP, HMBS, UROD, BLVRA, UROS",0.31695296176115,0.20551195334083,FALSE +"H2009","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.36098,1.19,0.237,1984,0.426,"FADS2, CYP27A1, ACADM, MMP1, ACAA1, APOA1, ACOX1, CPT2, ACSL4, SORBS1, SLC27A4, SCP2, ACSL3, FABP2, RXRA, APOC3",0.625251653989896,0.370590400897281,FALSE +"H2009","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45448,1.49,0.0966,2446,0.235,"CYP27A1, SCP2, HSD17B4, AMACR",1.01502287358451,0.628932137728264,FALSE +"H2009","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.17553,0.573,0.974,933,1,"RFXAP, RFXANK",0.0114410431213845,0,FALSE +"H2009","Input","KEGG_PRION_DISEASES",-0.48858,-1.55,0.0663,6110,0.313,"PRNP, PRKACA, STIP1, NCAM2, MAP2K1, MAP2K2, C9, MAPK1, IL1A, BAX, MAPK3, SOD1, NCAM1",1.17848647159523,0.504455662453552,FALSE +"H2009","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.30465,-0.971,0.427,7495,0.603,"MAPK14, MAPK12, GNAI1, CDK1, PIK3R2, MAPK1, MAPK8, HSP90AB1, ARAF, ADCY5, HSP90AA1, AKT1, BRAF, MAPK3, ADCY6, PIK3CA, PIK3R1, AKT2, RAF1",0.369572124974976,0.219682687859849,FALSE +"H2009","Input","KEGG_PROPANOATE_METABOLISM",0.42598,1.37,0.111,2236,0.332,"ACADM, ALDH1B1, ACSS3, MCEE, ACAT1, ECHS1, HADHA, PCCB, SUCLG2, ALDH2, PCCA, SUCLG1, ALDH7A1",0.954677021213343,0.478861916295964,FALSE +"H2009","Input","KEGG_PROSTATE_CANCER",-0.41227,-1.32,0.162,7178,0.358,"MTOR, PIK3CB, CASP9, MAP2K2, IKBKG, NFKB1, SOS1, PTEN, PIK3R2, MAPK1, HSP90AB1, ARAF, CDKN1A, PDGFRA, HSP90AA1, RELA, PDGFRB, AKT1, BRAF, MAPK3, FGFR2, PIK3CA, GSK3B, PIK3R1, GSTP1, AKT2, IKBKB, CDKN1B, FOXO1, FGFR1, RAF1, CCND1, RB1",0.790484985457369,0.446116973356126,FALSE +"H2009","Input","KEGG_PROTEASOME",-0.20163,-0.645,0.906,2341,0.965,"PSMD4, PSME3, PSMB10, PSMB6, PSMC5, PSMB7, PSMC6, PSMC3, PSMC4, PSMA1, PSMC2, PSMD14, PSMA4, PSMB9, PSMB2, PSMB3, PSMB4, PSMC1, PSMA3, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB5, PSMA2, PSME4, PSMD2, PSMD11, PSMD6, PSMD7, PSMD13, PSMD1, PSMD8, SEM1, PSMD12, PSMD3, POMP, PSME1, PSME2, PSMF1",0.0428718023231869,0.0154726866562074,FALSE +"H2009","Input","KEGG_PROTEIN_EXPORT",-0.23798,-0.772,0.739,5254,0.833,"SEC63, SRP68, SRPRB, SPCS1, OXA1L, SRP14, SEC61B, SEC61A1, SRP19, SRP54, SEC11C",0.131355561605174,0.0793549985932124,FALSE +"H2009","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.39199,1.28,0.172,1189,0.384,"GLUD2, ATP1A2, ATP1B1, GLS, GLS2",0.764471553092451,0.415668775632469,FALSE +"H2009","Input","KEGG_PURINE_METABOLISM",-0.29485,-0.983,0.467,6958,0.59,"NT5C3A, GMPS, PKM, PRPS2, NUDT9, GUCY1A1, NT5C2, DCK, GMPR2, PDE5A, PDE2A, NT5C, PAICS, PNP, PRPS1, PRPS1L1, PDE8A, XDH, RRM2B, HPRT1, IMPDH2, ADCY5, PKLR, NME3, ADSL, ADCY6, ATIC, NME1, APRT, NUDT5, GART, ADA, AMPD2, ITPA, RRM2, PFAS, RRM1, NUDT2",0.330683119433888,0.229147988357856,FALSE +"H2009","Input","KEGG_PYRIMIDINE_METABOLISM",-0.23517,-0.749,0.764,7236,0.857,"NT5C2, DCK, UPP1, NT5C, DPYD, PNP, DUT, CTPS2, RRM2B, TYMS, DCTD, NME3, CAD, UPRT, NME1, UMPS, CTPS1, ITPA, RRM2, RRM1, NUDT2",0.11690664142431,0.0670191780768018,FALSE +"H2009","Input","KEGG_PYRUVATE_METABOLISM",-0.22973,-0.732,0.808,6465,0.852,"HAGHL, ACSS1, ACACA, GRHPR, PKM, HAGH, ACACB, ACAT2, ACYP1, LDHA, PCK2, MDH1, PKLR, ACSS2",0.0925886392254138,0.0695604052332999,FALSE +"H2009","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.23404,-0.748,0.743,6428,0.85,"ARPC4, ACTG1, ARHGEF6, GIT1, IQGAP1, PIP4K2B, ARPC1A, ITGA1, VAV3, MSN, CFL1, WASL, SSH1, DIAPH1, MAP2K1, ARHGEF7, PAK3, MYH14, ROCK1, PXN, PIK3CB, CYFIP2, F2R, PAK2, MAP2K2, CRKL, LIMK2, IQGAP3, MYH10, SOS1, PTK2, ARHGEF1, MYH9, CYFIP1, PIK3R2, MAPK1, VAV2, GNA12, CRK, ROCK2, ARAF, PDGFRA, ITGB3, PFN1, PDGFRB, BRAF, MAPK3, DIAPH3, FGFR2, VCL, PIK3CA, SSH3, ARHGAP35, PIK3R1, DOCK1, GNA13, CSK, FGFR1, RAF1, WAS",0.129011186239425,0.0705810742857073,FALSE +"H2009","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.62889,-2.01,0.00526,8159,0.334,"ATG7, ATG4B, PRKAA1, PIK3R4, PIK3C3, ATG3",2.27901425584626,0.476253533188435,FALSE +"H2009","Input","KEGG_RENAL_CELL_CARCINOMA",-0.3157,-1.02,0.382,6980,0.544,"MAP2K1, PAK3, RAPGEF1, PIK3CB, PAK2, MAP2K2, CRKL, HGF, SOS1, PIK3R2, MAPK1, CRK, EGLN1, FLCN, ARAF, CUL2, AKT1, BRAF, TGFB3, MAPK3, PTPN11, PIK3CA, PIK3R1, AKT2, RAF1",0.417936637088291,0.26440110030182,FALSE +"H2009","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.58364,-1.91,0.0223,8618,0.346,"MME, ACE, CTSG, ACE2",1.65169513695184,0.460923901207223,FALSE +"H2009","Input","KEGG_RETINOL_METABOLISM",-0.38306,-1.22,0.22,9074,0.419,"ADH5, ALDH1A1",0.657577319177794,0.377785977033705,FALSE +"H2009","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.35905,-1.14,0.282,6823,0.467,"ACP2, RFK, ACP1, PHPT1, MTMR2, MTMR6",0.549750891680639,0.330683119433888,FALSE +"H2009","Input","KEGG_RIBOSOME",-0.6532,-2.1,0.0121,6319,0.436,"RPL35, RPLP0, RPS4Y1, RPL23, RPL22L1, RPS15A, RPL23A, RPL36, RPL24, RSL24D1, RPL22, RPS7, RPL3, RPS19, RPL17, RPS8, RPL10, RPL15, RPS6, RPS15, RPL5, RPS4X, RPL7, RPS20, RPL30, RPS17, RPL31, RPS3, RPS24, RPS3A, RPL18A, RPL9, RPL27A, RPS25, RPS26, RPL35A, RPS5, RPL10A, RPL27, RPS13, RPL8, RPL4, RPL37A, RPL18, RPL21, RPL26, RPS2, RPL32, RPL29, RPS16, RPL6, RPL7A, RPL13A, RPL14, RPL28, RPS9, RPL37, RPS10, RPS18, RPL34, UBA52, RPL19, RPS11, FAU, RPS27L, RPS23, RPL36A, RPL36AL, RPL38, RPL26L1",1.91721462968355,0.360513510731414,FALSE +"H2009","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.55481,-1.76,0.0357,6379,0.376,"ATG5, MAPK9, MAVS, TRAF3, MAP3K7, TRIM25, MAPK10, NFKBIB, DHX58, IKBKG, TBKBP1, NFKB1, MAPK14, MAPK12, CASP8, TANK, TRAF2, IRF3, MAPK8, DDX58, RIPK1, TBK1, RELA, FADD, PIN1, DDX3Y, TRAF6, CYLD, IKBKB, TKFC",1.44733178388781,0.424812155072339,FALSE +"H2009","Input","KEGG_RNA_DEGRADATION",-0.17392,-0.564,0.962,6984,0.984,"CNOT4, CNOT6L, XRN1, CNOT7, XRN2, DCP2, DIS3, ENO1, PATL1, LSM1, ENO3, TTC37, SKIV2L, DCP1B",0.0168249279621871,0.00700490156865849,FALSE +"H2009","Input","KEGG_RNA_POLYMERASE",0.4584,1.5,0.0979,3369,0.237,"POLR2D, POLR2L, POLR1E, POLR2I, POLR2K, POLR2G, POLR3K, POLR2J, POLR2C, POLR2F, POLR2E, POLR3H, POLR3F, POLR3D, POLR1C, POLR1D, POLR2A, POLR2H",1.00921730819686,0.625251653989896,FALSE +"H2009","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.38989,-1.21,0.225,5400,0.416,"MAT2B, GGT1, TRMT11, SEPHS2, AHCYL1, AHCYL2, PAPSS2, MAT2A, BUD23, METTL2B, CTH, SCLY, MAT1A, LCMT1, AHCY, CBS, LCMT2",0.647817481888638,0.380906669373257,FALSE +"H2009","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.31011,1.04,0.377,586,0.532,"LAMC2, TP53, ITGA2B, LAMB3, ITGA6, ITGA3, LAMA3, LAMA4, PIK3R3, ITGA2, LAMB1, ITGAV",0.423658649794207,0.274088367704952,FALSE +"H2009","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.29441,0.958,0.467,2020,0.548,"VAMP8, GOSR1, STX17, VAMP4, STX10, STX6, GOSR2, STX12",0.330683119433888,0.261219441515631,FALSE +"H2009","Input","KEGG_SPHINGOLIPID_METABOLISM",0.48509,1.63,0.0462,483,0.246,"PLPP2, NEU1, UGT8, PLPP3, GLA",1.33535802444387,0.609064892896621,TRUE +"H2009","Input","KEGG_SPLICEOSOME",0.5245,1.74,0.0414,2839,0.194,"ISY1, PHF5A, HNRNPA3, SNRNP70, SRSF1, SNRPB, PRPF4, PRPF40B, SF3B4, HNRNPC, SNRPC, U2AF1, PPIE, SNRPG, U2AF2, SRSF9, NCBP2, SNRPD3, TRA2A, SF3B5, SNRPF, DHX8, TCERG1, PUF60, THOC3, SRSF10, RBM25, SRSF3, SF3B2, PRPF40A, SRSF7, LSM8, SRSF8, PRPF3, DDX5, LSM4, SF3B6, RBMX, TRA2B, LSM6, SNRPA1, SNRPA, HNRNPA1, SRSF4, SF3A1, HNRNPK, DDX23, SF3B1, SRSF5, BCAS2, U2SURP, DDX46, SRSF6, LSM7, DHX38, PPIH, ALYREF, DDX42, PRPF19, ZMAT2, RBM17, RBM8A, SNRNP40, PQBP1, SNRPB2, THOC1, LSM2, HSPA1L, SF3A3, SRSF2, PRPF38A, SNW1, SF3B3",1.3829996588791,0.712198270069774,TRUE +"H2009","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.389,-1.24,0.199,5667,0.416,"UGT2B11, UGT2B4, PYGB, GUSB, AGL, PYGL, UGP2, GCK, HK3, PGM2, PGM1, GYS1, GBE1, GPI",0.701146923590293,0.380906669373257,FALSE +"H2009","Input","KEGG_STEROID_BIOSYNTHESIS",0.4863,1.62,0.0605,1862,0.226,"MSMO1, SOAT1, FDFT1, HSD17B7, SQLE, CYP27B1, DHCR24, NSDHL",1.21824462534753,0.645891560852599,FALSE +"H2009","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.34609,-1.12,0.308,7659,0.465,"AKR1C1, AKR1C3, AKR1D1, CYP21A2",0.511449283499556,0.332547047110046,FALSE +"H2009","Input","KEGG_SULFUR_METABOLISM",0.47416,1.58,0.0698,2177,0.229,"CHST11, SULT1A3, CHST12, PAPSS1",1.15614457737684,0.640164517660112,FALSE +"H2009","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.27638,-0.883,0.55,7154,0.706,"C3, C9, C4A, TRIM21, CTSG",0.259637310505756,0.151195298948196,FALSE +"H2009","Input","KEGG_TASTE_TRANSDUCTION",-0.3025,-0.967,0.45,8567,0.603,"ADCY6, PLCB2",0.346787486224656,0.219682687859849,FALSE +"H2009","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.47856,-1.57,0.0664,6679,0.332,"FDPS, PMVK, MVK, ACAT2, IDI1, MVD, GGPS1",1.17783192063198,0.478861916295964,FALSE +"H2009","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.32172,-1.02,0.362,6779,0.544,"ZFYVE16, BMPR2, PPP2CA, ROCK1, RPS6KB1, ID3, AMH, RPS6KB2, PPP2R1B, MAPK1, ROCK2, SMAD2, SMAD5, SMAD9, SMAD1, TGFB3, MAPK3, PPP2CB",0.441291429466834,0.26440110030182,FALSE +"H2009","Input","KEGG_THYROID_CANCER",0.38556,1.24,0.18,1410,0.397,"TP53, CTNNB1, CDH1, HRAS, KRAS, NRAS, NCOA4, TPR, MYC",0.744727494896694,0.401209493236885,FALSE +"H2009","Input","KEGG_TIGHT_JUNCTION",0.30393,1,0.365,1297,0.542,"CLDN7, CGN, F11R, CTNNB1, AMOTL1, CTNNA1, TJP3, CTNNA2, CASK, MYH2, MPDZ, PATJ, HRAS, TJP1, VAPA, SPTAN1, ACTN4, KRAS, NRAS, LLGL2, TJP2, AFDN, RAB3B, ASH1L",0.437707135543525,0.266000713461613,FALSE +"H2009","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.48209,-1.56,0.0701,6703,0.328,"STAT1, TRAF3, MAP3K7, SPP1, MAP2K1, MAPK10, IRAK4, PIK3CB, MAP2K2, IKBKG, NFKB1, MAPK14, MAPK12, MAP2K7, CASP8, IRF3, PIK3R2, MAPK1, MAPK8, MAP2K4, MYD88, RIPK1, TBK1, RELA, AKT1, FADD, MAPK3, PIK3CA, TAB2, TRAF6, PIK3R1, AKT2, IKBKB, MAP2K3",1.15428198203334,0.484126156288321,FALSE +"H2009","Input","KEGG_TRYPTOPHAN_METABOLISM",0.32458,1.07,0.324,1258,0.506,"ALDH1B1, MAOA, ACAT1, ECHS1, HADH, HADHA",0.489454989793388,0.295849483160201,FALSE +"H2009","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.44209,-1.45,0.102,6930,0.339,"GCK, PKM, MAPK10, MTOR, HK3, PIK3CB, PIK3R2, MAPK1, MAPK8, PRKCZ, PKLR, MAPK3, PIK3CA, PIK3R1, SOCS2, IKBKB",0.991399828238082,0.469800301796918,FALSE +"H2009","Input","KEGG_TYROSINE_METABOLISM",-0.52439,-1.67,0.0403,6402,0.371,"TAT, MAOB, FAH, BUD23, METTL2B, DDC, DCT, MIF, PNMT, LCMT1, NAA80, ALDH3A1, GSTZ1, ADH5, LCMT2",1.39469495385889,0.430626090384954,FALSE +"H2009","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.43728,-1.4,0.134,6633,0.338,"BCL10, VAV3, PPP3CC, PTPN6, MAP3K7, NCK2, MAP2K1, PAK3, PIK3CB, NFKBIB, PAK2, MAP2K2, NCK1, IKBKG, PRKCQ, NFKB1, MAPK14, MAPK12, SOS1, MAP2K7, NFATC2, PIK3R2, MAPK1, VAV2, NFKBIE, RELA, CBL, AKT1, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, PLCG1, MALT1, CBLB, IKBKB, RAF1",0.872895201635192,0.471083299722345,FALSE +"H2009","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.3559,-1.15,0.27,7777,0.46,"UBE2O, PIAS2, UBE2M, CDC34, UBE2L3, SIAH1, FBXW8, CUL2, BIRC6, NEDD4L, CUL7, UBE2R2, UBE2G1, NEDD4, CBL, HERC1, UBE2D2, UBE2N, DDB2, UBE3C, UBE2E1, UBE2D4, UBA1, TRAF6, UBE2NL, HERC4, UBE3B, CBLB, UBE3A, PIAS4",0.568636235841013,0.337242168318426,FALSE +"H2009","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.48592,1.61,0.0591,1659,0.221,"PDHA1, PDHB, BCAT2",1.22841251911874,0.655607726314889,FALSE +"H2009","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.58129,1.92,0.0265,2597,0.209,"ACADM, ALDH1B1, OXCT1, ACAA1, DBT, MCEE, ACAT1, ECHS1, HADHB, HADH, HADHA, MCCC2, PCCB, ACADSB, BCAT2, ALDH2, PCCA, AUH, ALDH7A1, BCKDHA, HMGCL, BCKDHB, ALDH3A2",1.57675412606319,0.679853713888946,TRUE +"H2009","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.46886,-1.55,0.0787,5982,0.313,"ARHGEF11, ITPR2, PRKCD, PRKG1, MYL6, ARHGEF12, GNAS, PRKACA, PRKCA, PLCB3, MAP2K1, PRKCB, ROCK1, GUCY1A1, MAP2K2, PRKCQ, ARHGEF1, MAPK1, GNA12, ROCK2, ARAF, MYH11, ADCY5, BRAF, KCNMA1, MAPK3, ADCY6, CALD1, PLCB4, GNA13, PLCB2, RAF1",1.10402526764094,0.504455662453552,FALSE +"H2009","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.35698,-1.16,0.244,7018,0.453,"DYNC2LI1, DCTN4, DCTN5, DCTN6, ARHGDIA, DCTN2, DYNC1LI2, DCTN1, DYNC1I2, ADCY6, DYNC1LI1, DYNC1H1",0.612610173661271,0.343901797987168,FALSE +"H2009","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.30473,-0.962,0.44,6980,0.604,"MAP2K1, PRKCB, PXN, PIK3CB, CASP9, PLCG2, MAP2K2, HSPB1, MAPK14, MAPK12, PTK2, NFATC2, PIK3R2, MAPK1, MAPKAPK2, AKT1, MAPK3, PIK3CA, PIK3R1, AKT2, PLCG1, RAF1",0.356547323513813,0.218963061378868,FALSE +"H2009","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.37068,-1.2,0.215,6251,0.422,"GNAS, ATP6V0C, PRKACA, PRKCA, ACTG1, SEC61B, ATP6V1C2, ATP6V1D, SEC61A1, SLC12A2, PRKCB, ATP6V1E1, ATP6V1G1, PLCG2, ATP6V1H, ATP6V1B2, ATP6V1B1, ATP6V1A, ATP6V1C1, PLCG1",0.667561540084395,0.374687549038326,FALSE +"H2009","Input","KEGG_VIRAL_MYOCARDITIS",0.30864,1.01,0.408,425,0.546,"ITGB2, RAC2, CD55, MYH2",0.38933983691012,0.262807357295263,FALSE +"H2009","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.18723,-0.6,0.967,6125,0.971,"WNT5A, DVL2, SMAD4, CUL1, PRKACA, PRKCA, NFAT5, CSNK2A1, CSNK2A2, MAPK9, PPP2R1A, PPP3CC, MAP3K7, PLCB3, PPP2CA, MAPK10, PRKCB, CACYBP, ROCK1, PPP2R5C, CAMK2B, DVL3, PPP2R1B, CCND3, NFATC2, PPP2R5B, MAPK8, ROCK2, SIAH1, SMAD2, PPP2R5E, PPP2CB, NLK, PPP2R5A, GSK3B, PPP2R5D, PLCB4, PLCB2, CCND1",0.0145735259169983,0.0127807700919951,FALSE +"H2126","Input","KEGG_ABC_TRANSPORTERS",0.59912,1.75,0.023,1103,0.201,"ABCG2, ABCB6, ABCD1, ABCC3, ABCC2, ABCB8",1.63827216398241,0.696803942579511,TRUE +"H2126","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.22995,-0.68,0.868,7987,1,"TCF7L2, MYC, CCND1, PIK3R3, PML",0.0614802748235081,0,FALSE +"H2126","Input","KEGG_ADHERENS_JUNCTION",0.25036,0.726,0.83,1346,1,"NECTIN4, LMO7, PTPRM, CDH1, RAC2, WASL, CTNNA1, PTPRF, TGFBR1, IQGAP1, CTNNA2, RAC3",0.0809219076239261,0,FALSE +"H2126","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.51611,1.51,0.0621,2311,0.305,"PRKAB2, PRKAB1, PRKAG1, ACSL1, PRKAA1, ADIPOR1, PRKAG2, ACSL3, IRS2, NFKBIB, PRKAA2, CPT1A, IKBKG, SLC2A1, IKBKB, TRAF2, ACSL5, ACACB, ACSL6, AKT1, RELA, MTOR, CHUK, RXRG, RXRA",1.20690839982342,0.515700160653214,FALSE +"H2126","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.32409,-0.993,0.394,8469,0.79,"GFPT2, GLS, GLS2, DDO",0.404503778174426,0.102372908709559,FALSE +"H2126","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.20958,-0.634,0.928,7781,1,"PRKCB, IRS1, PIK3R3",0.0324520237811379,0,FALSE +"H2126","Input","KEGG_ALZHEIMERS_DISEASE",0.25428,0.74,0.799,2827,1,"ATP2A3, ITPR1, CASP9, NDUFA2, BID, UQCRH, EIF2AK3, CACNA1F, CAPN2, CYC1, CDK5, PSEN2, UQCR10, IDE, SNCA, CHP1, NDUFB1, NDUFAB1, ATP2A2, NDUFA9, MAPK3, UQCRQ, NDUFC2, ATP5MC2, NDUFB7, CYCS, NDUFV2, NDUFS6, UQCRB, NDUFA5, NDUFB6, PSEN1, CASP7, FAS, NDUFA7, NDUFC1, CASP3, NDUFS4",0.0974532206860086,0,FALSE +"H2126","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.21908,0.631,0.921,1725,1,"TARS2, NARS2, SEPSECS, VARS2, PARS2",0.0357403698031511,0,FALSE +"H2126","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.51946,1.52,0.0742,2147,0.308,"GNPNAT1, FPGT, GFPT1, GNPDA2, GALK2, NANS, PMM2, GNE, UGDH, PGM3, UXS1, GMDS, HK1, PGM2, PGM1, PMM1, MPI, GMPPA, GALE, CYB5R3, AMDHD2, NAGK, CYB5R1",1.12959609472097,0.511449283499556,FALSE +"H2126","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.32373,-1,0.389,7922,0.791,"NEFH, PRPH, PRPH2, GRIN1, BCL2L1, MAP2K6, TOMM40L, CASP1, TP53, GPX1",0.410050398674292,0.101823516502323,FALSE +"H2126","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.24207,-0.753,0.743,7492,1,"RFXANK, HSPA4, RFX5, CD74, TAP1, CTSS, CTSB",0.129011186239425,0,FALSE +"H2126","Input","KEGG_APOPTOSIS",0.22094,0.621,0.925,2238,1,"CASP9, MYD88, BID, CAPN2, BIRC2, BAX, AIFM1, IKBKG, XIAP, CHP1, IKBKB, TRAF2, AKT1, IRAK4, RELA, ENDOG, CYCS, CHUK",0.0338582672609674,0,FALSE +"H2126","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.5093,1.48,0.0724,812,0.325,"PTGES, PLA2G12A, PLA2G4A, GPX2, LTA4H",1.14026143380285,0.488116639021126,FALSE +"H2126","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.33614,0.977,0.457,989,0.755,"AGMAT, GLUL, CKMT1A, PYCR1, CKMT2, GAMT, CPS1, GATM, OAT, ODC1, SRM, ALDH18A1",0.34008379993015,0.122053048370812,FALSE +"H2126","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.53299,-1.63,0.0741,7855,0.593,"LAMA2, TCF7L2, ITGB8, CACNA2D2, ITGA2B, ITGA2, DSC2, ITGA6, ACTN1, LMNA, ITGA10, ITGB4, ACTG1, SGCB, CDH2, ITGB3, GJA1, CACNA2D1",1.13018179202067,0.226945306635737,FALSE +"H2126","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.37229,-1.15,0.266,7617,0.667,"ALDH1B1, ALDH9A1",0.575118363368933,0.175874166083451,FALSE +"H2126","Input","KEGG_AXON_GUIDANCE",-0.42414,-1.28,0.16,7255,0.685,"ROBO1, EFNA5, ABLIM1, SEMA4B, PAK3, SRGAP2, SRGAP3, EPHA7, DPYSL5, PLXNA1, ABLIM2, CXCR4, CFL2, GNAI1, EPHB3, PLXNA2, ABLIM3, PAK2, EPHB2, NFAT5, EPHA2, EPHA6, EPHA5, SEMA3A, DPYSL2, EFNB1, EPHA4, PLXNB3, NFATC2, EFNB2, SEMA5A",0.795880017344075,0.164309428507574,FALSE +"H2126","Input","KEGG_BASAL_CELL_CARCINOMA",-0.6756,-2.1,0.00862,7503,0.778,"WNT5A, SUFU, FZD1, TCF7L2, GLI2, GLI3, FZD7, TP53",2.06449273417529,0.109020403010311,FALSE +"H2126","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.54803,-1.66,0.0506,5616,0.691,"GTF2F1, GTF2E1, GTF2E2, GTF2IRD1, TAF5, TAF4, GTF2F2, TAF9, TAF6L, GTF2I, GTF2A1, TAF7, GTF2H2, TAF5L, GTF2H1, GTF2B, GTF2A2",1.2958494831602,0.160521952625802,FALSE +"H2126","Input","KEGG_BASE_EXCISION_REPAIR",-0.16099,-0.491,0.997,6400,1,"POLD3, MBD4, POLL, POLE3, POLD2, LIG1, FEN1, POLD1, POLE, POLE2",0.00130484168834428,0,FALSE +"H2126","Input","KEGG_BETA_ALANINE_METABOLISM",0.31702,0.907,0.554,900,0.809,"ACADM, SRM",0.25649023527157,0.0920514783877277,FALSE +"H2126","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.35363,1.02,0.387,2304,0.694,"ACOX3, HACD1, ELOVL5, ACAA1, ACOT2, SCD, FADS2, ACOT1, TECR",0.412289034981089,0.158640529545145,FALSE +"H2126","Input","KEGG_BLADDER_CANCER",-0.40679,-1.22,0.234,7877,0.651,"DAPK1, MMP1, MYC, CCND1, CDKN2A, TP53, THBS1",0.630784142589857,0.186419011431808,FALSE +"H2126","Input","KEGG_BUTANOATE_METABOLISM",-0.52691,-1.62,0.0582,7606,0.502,"ALDH5A1, ALDH1B1, BDH1, ALDH9A1, BDH2, HMGCS2, ACSM3, OXCT1",1.23507701535011,0.299296282854981,FALSE +"H2126","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.24858,-0.752,0.748,7781,1,"PRKCB, CARD11, BTK, LYN, NFAT5, JUN, PIK3R3, NFATC2, CD79A",0.126098402135539,0,FALSE +"H2126","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2744,0.791,0.717,2265,0.985,"ATP2A3, ITPR1, CACNA1A, CD38, PHKA1, ATP2B1, SLC25A5, CACNA1F, VDAC2, LTB4R2, P2RX4, GNA11, PHKB, CHP1, ERBB3, ATP2A2, PHKG2, HRH1, SLC25A31, PHKA2, TACR1, SLC25A6, PPID, SPHK2",0.1444808443322,0.00656376950238827,FALSE +"H2126","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.2875,-0.89,0.543,7402,0.919,"COX6B1, COX7C, TPM2, CACNA2D2, COX6A1, COX7A2, CACNA2D1",0.265200170411153,0.0366844886138887,FALSE +"H2126","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.31486,0.907,0.56,449,0.809,"CLDN3, CDH5, CLDN7, PTPRM, CD40, ITGB2, CDH1",0.2518119729938,0.0920514783877277,FALSE +"H2126","Input","KEGG_CELL_CYCLE",-0.29725,-0.913,0.514,6666,0.896,"SMC1A, PRKDC, WEE1, CDK4, CREBBP, SMAD4, E2F3, PLK1, RBL1, MCM2, RAD21, SMC1B, CCNA2, MAD2L1, SMC3, HDAC1, MCM7, MCM6, SMAD3, MCM3, CDKN2D, ORC6, MAD1L1, CDC25C, MCM4, MYC, ATR, PTTG1, CCND1, TGFB2, CDKN2A, TP53, CDK6, CDKN2C",0.289036881004724,0.0476919903378748,FALSE +"H2126","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.17888,-0.557,0.979,7139,1,"PLCB2, PLCB3, PREX1, VAV1, ELMO1, GRK6, CXCR4, PRKCB, GNB4, GNAI1, CXCL5, LYN, ADCY3, ADCY8, WAS, GNG7, CCL5, PIK3R3, GNG4",0.00921730819686218,0,FALSE +"H2126","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.37521,-1.18,0.233,6791,0.629,"CDK4, NFKB1, SMAD4, E2F3, CTBP2, RUNX1, HDAC1, BAD, SMAD3, TGFBR2, BCL2L1, MYC, CCND1, TGFB2, MECOM, CDKN2A, GAB2, TP53, CDK6, PIK3R3",0.632644078973981,0.201349354554731,FALSE +"H2126","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.67963,1.99,0.00444,862,0.155,"BHLHE41, PER2, CSNK1E",2.35261702988538,0.809668301829709,TRUE +"H2126","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.26045,0.743,0.772,2193,1,"ACLY, IDH2, DLAT, MDH2, IDH1, SUCLG2, DLST, DLD",0.112382699664264,0,FALSE +"H2126","Input","KEGG_COLORECTAL_CANCER",-0.26635,-0.803,0.668,7455,1,"BAD, APPL1, SMAD3, TCF7L2, TGFBR2, MYC, CCND1, TGFB2, JUN, TP53, PIK3R3",0.175223537524454,0,FALSE +"H2126","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.47122,1.37,0.131,256,0.381,"FGA, FGG, TFPI, FGB, MASP1, PLAUR",0.882728704344236,0.419075024324381,FALSE +"H2126","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.28799,0.815,0.7,2023,0.949,"CTH, ENOPH1, LDHA, SRM, ADI1, GOT1, AHCYL1, TAT",0.154901959985743,0.0227337875727074,FALSE +"H2126","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.38952,-1.23,0.181,7335,0.655,"IL1RAP, BMPR2, TNFRSF10A, CXCR4, PLEKHO2, TNFRSF21, ACVR2A, CXCL5, CD70, TGFBR2, IFNAR1, TNFRSF10D, IL6ST, TGFB2, TNFRSF10B, CCL5, INHBA, NGFR",0.742321425130815,0.183758700008217,FALSE +"H2126","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.2747,-0.843,0.578,8380,0.951,"ZBP1, TREX1, CASP1, CCL5",0.238072161579471,0.0218194830625861,FALSE +"H2126","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.47591,-1.48,0.0914,7835,0.57,"TPM2, LAMA2, ITGB8, CACNA2D2, ADCY3, ADCY8, ITGA2B, ITGA2, TGFB2, ITGA6, LMNA, ITGA10, ITGB4, ACTG1, SGCB, ITGB3, CACNA2D1",1.03905380426617,0.244125144327509,FALSE +"H2126","Input","KEGG_DNA_REPLICATION",-0.41424,-1.28,0.184,6307,0.685,"POLA2, POLD3, RPA3, POLE3, POLD2, POLA1, MCM2, LIG1, FEN1, PRIM2, MCM7, POLD1, MCM6, POLE, MCM3, POLE2, MCM4",0.735182176990464,0.164309428507574,FALSE +"H2126","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.23097,-0.714,0.801,7978,1,"NOTCH2, NOTCH1",0.0963674839157623,0,FALSE +"H2126","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.46523,1.36,0.112,487,0.382,"ALDH3B1, GSTM3, GSTK1, MGST2, MGST1, ALDH1A3, GSTZ1",0.950781977329818,0.417936637088291,FALSE +"H2126","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.31743,0.924,0.529,929,0.815,"CDA, CES1, CES2, TYMP, TPMT",0.276544327964814,0.0888423912600234,FALSE +"H2126","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.55437,-1.68,0.0542,7522,0.902,"ITGA3, COL5A1, COL5A2, LAMB3, SPP1, COL1A1, LAMC2, LAMA2, COL4A2, CD47, COL6A1, LAMB2, LAMC1, ITGB8, HMMR, COL1A2, ITGA2B, FN1, ITGA2, ITGA6, ITGA10, ITGB4, THBS1, ITGB3, THBS2, COL6A2, COL4A1",1.26600071346161,0.0447934624580583,FALSE +"H2126","Input","KEGG_ENDOCYTOSIS",0.30537,0.899,0.575,2973,0.813,"ARRB1, CHMP2A, ARFGAP1, ARFGAP3, USP8, DAB2, CHMP2B, HSPA2, PIKFYVE, RAB31, ARRB2, PSD, RAB11FIP4, SMURF1, ACAP1, VPS37C, CHMP5, RAB11A, ASAP2, STAM2, CHMP4A, CHMP4B, CHMP1B, PIP5K1C, VPS25, PLD2, ERBB3, VPS45, EHD1, AP2A1, SNF8, RAB22A, NEDD4, PLD1, CHMP4C, CLTC, RAB11B, HSPA1L, SH3GL1, CDC42, ITCH, AP2M1, SMAP1, HSPA6, CHMP3, HSPA1A, RAB5B, DNAJC6, VPS37A, CBL, STAMBP, EGFR, VPS36",0.24033215531037,0.0899094544059319,FALSE +"H2126","Input","KEGG_ENDOMETRIAL_CANCER",-0.20567,-0.625,0.944,7987,1,"TCF7L2, MYC, CCND1, TP53, PIK3R3",0.025028005701931,0,FALSE +"H2126","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.22622,-0.708,0.856,8136,1,"LYN, ATP6V1B2, JUN, CCL5, HBEGF, PTPRZ1",0.0675262353228468,0,FALSE +"H2126","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.25997,-0.813,0.678,6992,0.993,"NCK1, PAK1, CAMK2D, PAK3, PLCG2, BAD, PRKCB, CAMK2B, MYC, PAK2, JUN, HBEGF, NRG1, PIK3R3, CAMK2G",0.168770306132937,0.00305075150461883,FALSE +"H2126","Input","KEGG_ETHER_LIPID_METABOLISM",0.50907,1.46,0.0739,2183,0.321,"PLA2G12A, PLA2G4A, PAFAH2, PLPP3, PLD2, PLD1, PAFAH1B3, PLA2G7",1.13135556160517,0.493494967595128,FALSE +"H2126","Input","KEGG_FATTY_ACID_METABOLISM",-0.27864,-0.853,0.605,7617,0.943,"ALDH1B1, ADH4, ADH7, ACADSB, ADH1C, ALDH9A1, ACAA2, GCDH, ECI1, ACSL4",0.218244625347531,0.0254883072626717,FALSE +"H2126","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.2122,0.605,0.937,2447,1,"PLA2G12A, PLA2G4A, RAC2, PRKCD, VAV2, RAC3, MAPK13, RAC1, AKT1, MAPK3, GRB2, PDPK1, MAPK12, SOS1",0.0282604091122217,0,FALSE +"H2126","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.22441,-0.68,0.841,8136,1,"LYN, ARPC1A, PTPRC, SCIN, WAS, ASAP3, PLPP1, GAB2, WASF1, PIK3R3",0.0752040042020878,0,FALSE +"H2126","Input","KEGG_FOCAL_ADHESION",-0.35199,-1.09,0.33,7522,0.732,"ITGA3, COL5A1, COL5A2, LAMB3, SPP1, COL1A1, PRKCB, LAMC2, LAMA2, COL4A2, COL6A1, LAMB2, LAMC1, ITGB8, COL1A2, PAK2, ITGA2B, CCND1, FLNA, FN1, ITGA2, ITGA6, JUN, ACTN1, CAV1, FLNC, ITGA10, ITGB4, THBS1, PIK3R3, ACTG1, MYLK, ITGB3, THBS2, COL6A2, COL4A1",0.481486060122112,0.135488918941608,FALSE +"H2126","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.51847,-1.67,0.0448,8658,0.779,"ALPI, ALPP, ALPG",1.34872198600186,0.108462542327436,FALSE +"H2126","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.5654,1.68,0.0329,1756,0.205,"FBP1, ALDOB, PHPT1, FPGT, FBP2, PFKFB4, PMM2, GMDS, HK1, AKR1B1, PMM1, MPI, GMPPA, SORD",1.48280410205003,0.688246138944246,TRUE +"H2126","Input","KEGG_GALACTOSE_METABOLISM",0.33023,0.975,0.469,2577,0.731,"GALK2, B4GALT1, HK1, PGM2, AKR1B1, PGM1, GALE, PFKP, HK2, GALK1",0.328827157284917,0.13608262304214,FALSE +"H2126","Input","KEGG_GAP_JUNCTION",-0.22428,-0.675,0.874,7005,1,"GNAS, PLCB2, PLCB3, CSNK1D, TUBA4A, PRKCB, GNAI1, ITPR3, TUBB4A, ADCY3, ADCY8, GJA1",0.058488567365597,0,FALSE +"H2126","Input","KEGG_GLIOMA",-0.38925,-1.18,0.244,8123,0.629,"CAMK2B, CCND1, CDKN2A, TP53, CDK6, PIK3R3, CAMK2G",0.612610173661271,0.201349354554731,FALSE +"H2126","Input","KEGG_GLUTATHIONE_METABOLISM",0.50785,1.46,0.0988,1457,0.321,"GSTM3, GSTK1, MGST2, MGST1, G6PD, TXNDC12, GPX2, GSTZ1, RRM2, IDH2, ODC1, SRM, MGST3, IDH1, RRM1",1.00524305541237,0.493494967595128,FALSE +"H2126","Input","KEGG_GLYCEROLIPID_METABOLISM",0.28383,0.82,0.672,1849,0.954,"GK2, AKR1A1, DGAT1, AKR1B1, PLPP3, DGKE, AGK, GPAT4, MGLL",0.172630726946175,0.0204516252959049,FALSE +"H2126","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40749,1.17,0.255,2154,0.556,"LPGAT1, PLA2G12A, PEMT, PLA2G4A, CDS1, MBOAT7, PTDSS2, PISD, PLPP3, DGKE, LYPLA2, PLD2, GPAT4, LPCAT3, PLD1, PTDSS1, GPAM",0.593459819566045,0.254925208417942,FALSE +"H2126","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.37929,1.09,0.327,675,0.622,"CTH, GAMT, GATM, GLDC, GCAT",0.485452247339714,0.206209615309181,FALSE +"H2126","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.36834,1.07,0.346,1343,0.62,"FBP1, ALDOB, ALDH3B1, ALDH1A3, FBP2, GALM, AKR1A1, ACSS2, LDHA, DLAT, HK1, PGK1, BPGM, PGM2, PGM1",0.460923901207223,0.207608310501746,FALSE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.34847,1.01,0.431,1989,0.701,"B3GAT3, CHPF2, CHST12, B4GALT7",0.365522729839268,0.154281982033341,FALSE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.3983,1.15,0.254,1989,0.537,"HS6ST2, B3GAT3, EXT1, B4GALT7",0.595166283380062,0.270025714300444,FALSE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.70892,2.06,0.00612,652,0.127,"ST3GAL2, ST3GAL1, B4GALT4, B4GALT1",2.21324857785444,0.896196279044043,TRUE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.69667,-2.07,0.0129,8038,0.311,"GLB1, ARSB, HEXB, HEXA, SGSH, HPSE",1.88941028970075,0.507239610973163,FALSE +"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.5861,1.69,0.0329,101,0.209,"ST3GAL2, ST3GAL1",1.48280410205003,0.679853713888946,TRUE +"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.59275,1.73,0.0267,101,0.189,"ST3GAL2, ST3GAL1",1.57348873863542,0.723538195826756,TRUE +"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.7532,2.14,0.00796,652,0.105,"B3GNT3, ST3GAL4, B4GALT4, B4GALT1",2.09908693226233,0.978810700930062,TRUE +"H2126","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.81012,2.31,0,1328,0.0724,"PIGO, PIGU, PIGA, PIGK, PIGT, GPAA1, PIGS",Inf,1.14026143380285,TRUE +"H2126","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.29087,0.842,0.644,1256,0.921,"MDH2, PGP",0.191114132640188,0.0357403698031511,FALSE +"H2126","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.25041,0.735,0.812,266,1,"ITPR1, ADCY5, PLA2G12A, PLA2G4A",0.0904439707588247,0,FALSE +"H2126","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.52487,-1.61,0.0523,7343,0.474,"CSNK1D, WNT5A, SUFU, RAB23, GLI2, GLI3",1.28149831113273,0.324221658325915,FALSE +"H2126","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.50948,-1.58,0.0653,8329,0.479,"ITGA2B, ITGA2, ITGA6, CD33, ITGB3, CD7",1.18508681872493,0.319664486585437,FALSE +"H2126","Input","KEGG_HISTIDINE_METABOLISM",0.45345,1.33,0.137,478,0.408,"ALDH3B1, BUD23, ALDH1A3, METTL2B",0.863279432843593,0.38933983691012,FALSE +"H2126","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.22331,0.651,0.91,1620,1,"MUS81, SSBP1, RAD51, BLM",0.0409586076789064,0,FALSE +"H2126","Input","KEGG_HUNTINGTONS_DISEASE",-0.14886,-0.463,1,7136,0.998,"NDUFB9, PLCB2, PLCB3, POLR2L, BBC3, COX6B1, POLR2E, HDAC1, POLR2G, ATP5F1B, ATP5F1E, COX7C, ATP5PD, POLR2F, ATP5F1A, DLG4, ATP5PO, GRIN1, COX6A1, TP53, NDUFA4, COX7A2, GPX1, HIP1",0,0.000869458712628891,FALSE +"H2126","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.40467,-1.25,0.171,7835,0.692,"TPM2, LAMA2, ITGB8, CACNA2D2, ITGA2B, ITGA2, TGFB2, ITGA6, LMNA, ITGA10, ITGB4, ACTG1, SGCB, ITGB3, ACE, CACNA2D1",0.767003889607846,0.159893905543242,FALSE +"H2126","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.21722,0.639,0.927,1643,1,"OCRL, INPP4B, PIKFYVE, PIP4K2C, PI4KB, PIP5K1C, ITPK1, IMPA2, ALDH6A1",0.0329202658555029,0,FALSE +"H2126","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.37326,1.08,0.332,2333,0.614,"FBP1, PRKAB2, MKNK1, FBP2, PRKAB1, PRKAG1, PHKA1, PRKAA1, GYS1, PRKAG2, PYGL, RHEB, IRS2, PTPRF, HK1, PRKAA2, PYGM, RPS6KB2, SREBF1, PPP1R3D, PHKB, IKBKB, ACACB, AKT1, PHKG2, MTOR, MAPK3, PHKA2, GRB2, SHC1, ACACA, ARAF, HK2, PDPK1",0.478861916295964,0.211831628858832,FALSE +"H2126","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.42663,1.23,0.186,978,0.493,"CD40, LTBR",0.730487055782084,0.30715308072277,FALSE +"H2126","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.42385,-1.3,0.192,8043,0.708,"IRF9, IFNAR1, BCL2L1, MYC, IL6ST, CCND1, PIAS2, SPRED1, SPRY4, PIK3R3, SPRY1",0.71669877129645,0.149966742310231,FALSE +"H2126","Input","KEGG_LEISHMANIA_INFECTION",-0.23821,-0.698,0.791,8390,1,"TGFB2, JUN, C3, CYBA",0.101823516502323,0,FALSE +"H2126","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.22884,0.671,0.896,1784,1,"CLDN3, CDH5, CLDN7, ITGB2, RAC2, CTNNA1, PXN, VAV2, VASP, CTNNA2, ROCK1, OCLN, F11R, CTNND1, MAPK13, RAC1",0.0476919903378748,0,FALSE +"H2126","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.52114,-1.62,0.0739,7617,0.502,"ALDH1B1, ALDH9A1",1.13135556160517,0.299296282854981,FALSE +"H2126","Input","KEGG_LONG_TERM_DEPRESSION",0.40839,1.18,0.242,266,0.553,"ITPR1, PLA2G12A, CACNA1A, PLA2G4A",0.616184634019569,0.257274868695302,FALSE +"H2126","Input","KEGG_LONG_TERM_POTENTIATION",-0.24765,-0.748,0.754,7139,1,"PLCB2, PLCB3, CAMK2D, PRKCB, ITPR3, GRIN1, CAMK2B, ADCY8, CAMK2G",0.122628654130226,0,FALSE +"H2126","Input","KEGG_LYSINE_DEGRADATION",-0.39531,-1.21,0.207,6028,0.65,"PLOD3, NSD1, NSD2, TMLHE, ACAT1, SETD1A, EHMT2, SUV39H1, SETDB2, SETDB1, NSD3, SETD2, ALDH1B1, ALDH9A1, GCDH, SETMAR, AASS, PLOD2",0.684029654543082,0.187086643357144,FALSE +"H2126","Input","KEGG_LYSOSOME",-0.28115,-0.883,0.578,7818,0.919,"AP3S1, CTSZ, MFSD8, IGF2R, GLB1, CTSV, PLA2G15, NPC2, CTSF, ARSB, SMPD1, SUMF1, PPT2, AP1S2, MANBA, HEXB, HEXA, CTSS, CTSB, SGSH, CTSK, CTSO",0.238072161579471,0.0366844886138887,FALSE +"H2126","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.23147,-0.72,0.799,7646,1,"DAXX, RPS6KA4, MAPKAPK3, PRKCB, SRF, RRAS2, TGFBR2, CACNA2D2, MYC, FGF13, FGF2, NTRK2, PAK2, MAP2K6, JUND, FLNA, TGFB2, FGFR2, DUSP16, JUN, MECOM, FLNC, TP53, NFATC2, CACNA2D1",0.0974532206860086,0,FALSE +"H2126","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.402,1.16,0.238,1039,0.56,"IAPP, PDX1",0.623423042943488,0.2518119729938,FALSE +"H2126","Input","KEGG_MELANOGENESIS",-0.40343,-1.27,0.163,6863,0.679,"ASIP, CREBBP, GNAS, DCT, PLCB2, PLCB3, CAMK2D, WNT5A, PRKCB, FZD1, GNAI1, TCF7L2, MITF, CAMK2B, ADCY3, ADCY8, FZD7, CAMK2G",0.787812395596042,0.168130225719498,FALSE +"H2126","Input","KEGG_MELANOMA",-0.43512,-1.35,0.161,8000,0.672,"MITF, FGF13, FGF2, CCND1, CDKN2A, TP53, CDK6, PIK3R3",0.79317412396815,0.172630726946175,FALSE +"H2126","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.49098,1.44,0.0861,487,0.331,"ALDH3B1, GSTM3, GSTK1, MGST2, CYP1B1, MGST1, ALDH1A3, GSTZ1",1.06499684854635,0.480172006224281,FALSE +"H2126","Input","KEGG_MISMATCH_REPAIR",0.15748,0.454,1,7463,1,"SSBP1, RFC1, MSH3, PCNA, POLD4, MLH3, RFC5, MSH6, RFC3, MSH2, RFC2, RPA1, RPA2, PMS2, RFC4, MLH1, POLD3, RPA3, POLD2, LIG1, POLD1",0,0,FALSE +"H2126","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.41873,1.23,0.188,2504,0.493,"CAB39L, PRKAA1, CAB39, RHEB, PRKAA2, RPS6KB2, EIF4B, AKT1, MTOR, MAPK3, RICTOR, PDPK1, MLST8",0.72584215073632,0.30715308072277,FALSE +"H2126","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.29637,-0.918,0.509,7327,0.918,"VAV1, PLCG2, TNFRSF10A, PRKCB, IFNAR1, TNFRSF10D, ULBP1, NFAT5, TNFRSF10B, PIK3R3, RAET1L, ULBP2, NFATC2",0.293282217663241,0.0371573187987575,FALSE +"H2126","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.40933,1.19,0.222,2607,0.549,"PRSS3, LTB4R2, P2RX4, HRH1, TSPO, P2RY11, TACR1, HCRTR1, MAS1",0.653647025549361,0.260427655549908,FALSE +"H2126","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.16712,-0.51,0.994,7214,1,"TRAF6, CAMK2D, PLCG2, BAD, KIDINS220, RPS6KA4, IRS1, CAMK2B, NTRK2, JUN, TP53, PIK3R3, NGFR, CAMK2G",0.00261361560268669,0,FALSE +"H2126","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.40558,-1.23,0.223,8093,0.655,"PNP, NNT, NT5E, BST1, NMNAT3, NUDT12",0.651695136951839,0.183758700008217,FALSE +"H2126","Input","KEGG_NITROGEN_METABOLISM",-0.48123,-1.43,0.122,8739,0.589,"CA2, GLS, GLS2, CA12",0.913640169325252,0.229884705212898,FALSE +"H2126","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.20752,0.594,0.968,2371,0.993,"CCL13, TAB3, NFKBIB, BIRC2, IKBKG, XIAP, IKBKB, MAPK13, RELA, MAPK3, CHUK, MAPK12, SUGT1",0.0141246426916063,0.00305075150461883,FALSE +"H2126","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.38277,-1.18,0.218,6694,0.629,"POLL, PRKDC, FEN1, NHEJ1",0.661543506395395,0.201349354554731,FALSE +"H2126","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.26276,-0.796,0.643,8344,1,"CCND1, CDKN2A, TP53, CDK6, PIK3R3",0.191789027075778,0,FALSE +"H2126","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.47003,-1.46,0.0864,6681,0.57,"SNW1, NCOR2, NUMBL, RBPJ, CREBBP, JAG1, JAG2, CTBP2, DLL3, MAML1, HDAC1, NOTCH2, DTX3L, MAML2, NOTCH1",1.06348625752111,0.244125144327509,FALSE +"H2126","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.19128,-0.583,0.968,6021,1,"RFC4, ERCC2, ERCC6, POLD3, RPA3, POLE3, POLD2, XPC, GTF2H2, LIG1, POLD1, GTF2H1, POLE, POLE2",0.0141246426916063,0,FALSE +"H2126","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.60494,1.78,0.0222,2635,0.212,"MGAT4A, ST6GAL1, ALG5, ALG8, DPAGT1, ALG9, DPM3, ALG13, ALG3, ALG6, B4GALT1, DOLPP1, DPM1, MAN1B1, MOGS, MAN1A1, STT3B, RPN2, ALG1, MAN2A1, ALG2, ALG14, STT3A, B4GALT3, MGAT1, RFT1, DAD1, DDOST, MAN2A2, ALG11",1.65364702554936,0.673664139071249,TRUE +"H2126","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.46831,-1.42,0.114,6939,0.574,"CNGB1, CAMK2D, CAMK2B, ADCY3, CAMK2G",0.943095148663527,0.241088107602027,FALSE +"H2126","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.34213,-1.07,0.326,6014,0.723,"MTHFD1, MTHFS, GART, SHMT2, MTHFD1L, ALDH1L1",0.486782399932061,0.140861702705469,FALSE +"H2126","Input","KEGG_OOCYTE_MEIOSIS",0.15329,0.439,1,123,0.999,"ITPR1, ADCY5",0,0.000434511774017692,FALSE +"H2126","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.5262,-1.63,0.0565,6833,0.593,"MAN2B2, GBA, FUCA2, MAN2B1, GLB1, MANBA, HEXB, HEXA",1.24795155218056,0.226945306635737,FALSE +"H2126","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.1508,-0.466,0.997,7354,1,"ATP6V1H, COX6B1, ATP6V1A, ATP5MG, ATP5F1B, ATP5F1E, COX7C, ATP5PD, ATP5ME, ATP5F1A, ATP5PO, COX6A1, ATP6V1B2, NDUFA4, COX7A2",0.00130484168834428,0,FALSE +"H2126","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.67285,1.94,0.0135,106,0.171,"GCNT3, GALNT6, ST3GAL2, ST3GAL1, GALNT3",1.86966623150499,0.767003889607846,TRUE +"H2126","Input","KEGG_P53_SIGNALING_PATHWAY",-0.33435,-1.04,0.35,8005,0.752,"COP1, ATR, CCND1, TNFRSF10B, CDKN2A, TP53, CDK6, THBS1, STEAP3, SERPINE1",0.455931955649724,0.123782159408358,FALSE +"H2126","Input","KEGG_PANCREATIC_CANCER",-0.22021,-0.677,0.855,8046,1,"TGFBR2, BCL2L1, CCND1, TGFB2, CDKN2A, TP53, CDK6, PIK3R3",0.0680338852718274,0,FALSE +"H2126","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.45499,1.3,0.16,536,0.424,"ENPP1, PPCDC, PPCS",0.795880017344075,0.372634143407267,FALSE +"H2126","Input","KEGG_PARKINSONS_DISEASE",0.24269,0.693,0.859,2827,1,"CASP9, NDUFA2, UQCRH, SLC25A5, CYC1, VDAC2, UBA7, UBE2L3, UQCR10, SNCA, UBE2J1, NDUFB1, NDUFAB1, SLC18A1, NDUFA9, UQCRQ, SLC25A31, NDUFC2, ATP5MC2, NDUFB7, SLC25A6, CYCS, PPID, UBE2G2, PARK7, NDUFV2, NDUFS6, UCHL1, UBE2G1, UQCRB, NDUFA5, NDUFB6, NDUFA7, NDUFC1, CASP3, NDUFS4",0.0660068361687577,0,FALSE +"H2126","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.23423,-0.727,0.777,8023,1,"TUBB4A, ARHGEF2, ARPC1A, HCLS1, WAS, ACTG1",0.109578981199086,0,FALSE +"H2126","Input","KEGG_PATHWAYS_IN_CANCER",-0.29321,-0.914,0.498,7429,0.91,"HDAC1, PLCG2, BAD, APPL1, WNT5A, ITGA3, SUFU, SMAD3, LAMB3, PRKCB, LAMC2, FZD1, LAMA2, DAPK1, COL4A2, TPR, TCF7L2, LAMB2, MITF, LAMC1, TGFBR2, MMP1, FOXO1, BCL2L1, MYC, FGF13, FGF2, ITGA2B, CCND1, FN1, ITGA2, FH, TGFB2, FGFR2, ITGA6, JUN, GLI2, GLI3, PIAS2, FZD7, MECOM, CDKN2A, GSTP1, TP53, CDK6, PIK3R3, PML, COL4A1",0.302770657240282,0.0409586076789064,FALSE +"H2126","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.46733,1.38,0.115,1831,0.382,"UGDH, AKR1B1, DCXR",0.939302159646388,0.417936637088291,FALSE +"H2126","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.62853,1.79,0.0216,1343,0.227,"FBP1, ALDOB, G6PD, FBP2, PRPS1, PRPS1L1, PRPS2, PGM2, RBKS, PGM1",1.66554624884907,0.643974142806877,TRUE +"H2126","Input","KEGG_PEROXISOME",0.47747,1.39,0.129,1757,0.382,"GSTK1, ACOX3, ABCD1, PXMP4, SCP2, PRDX1, ACSL1, ACAA1, ACSL3, IDH2, ECH1, SLC27A2, PEX1, SLC25A17, MPV17, PEX26, PMVK, PEX13, MVK, CAT, CRAT, IDH1, PEX16, AMACR, ACSL5, ACSL6, XDH",0.889410289700751,0.417936637088291,FALSE +"H2126","Input","KEGG_PHENYLALANINE_METABOLISM",0.39329,1.15,0.252,1031,0.537,"ALDH3B1, ALDH1A3, MIF",0.598599459218456,0.270025714300444,FALSE +"H2126","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25005,0.729,0.82,1584,1,"ITPR1, OCRL, CDS1, INPP4B, PIKFYVE, PIP4K2C, PI4KB, PIP5K1C, DGKE, ITPK1, IMPA2",0.0861861476162833,0,FALSE +"H2126","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.27965,-0.861,0.584,7910,0.94,"ALAS1, FECH, FTH1",0.233587152887601,0.0268721464003014,FALSE +"H2126","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.44366,1.29,0.15,872,0.425,"FABP6, FABP3, ACADM, ACOX3, OLR1, SCP2, GK2, ACSL1, ACAA1, ACSL3, SLC27A2, FABP5",0.823908740944319,0.371611069949688,FALSE +"H2126","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.37483,-1.13,0.273,7144,0.688,"RFXAP, RFXANK, RFX5, BTK, TAP1, PTPRC, CD79A",0.563837352959244,0.162411561764489,FALSE +"H2126","Input","KEGG_PRION_DISEASES",-0.32574,-1.01,0.401,8022,0.785,"LAMC1, NOTCH1, CCL5",0.396855627379818,0.105130343254747,FALSE +"H2126","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.19384,0.563,0.971,2436,0.998,"ADCY5, FZR1, PKMYT1, ANAPC11, CDC25B, CDC26, MAPK13, AKT1, MAPK3, CDC23, ANAPC4, GNAI3, ARAF, MAPK12, CDC16, ANAPC5",0.0127807700919951,0.000869458712628891,FALSE +"H2126","Input","KEGG_PROPANOATE_METABOLISM",-0.23567,-0.707,0.79,8092,1,"LDHB, ALDH9A1, ACSS3, ACSS1",0.102372908709559,0,FALSE +"H2126","Input","KEGG_PROSTATE_CANCER",-0.24166,-0.753,0.746,7987,1,"TCF7L2, FOXO1, CCND1, FGFR2, GSTP1, TP53, PIK3R3",0.127261172527331,0,FALSE +"H2126","Input","KEGG_PROTEASOME",-0.17793,-0.55,0.984,2238,1,"PSMA5, PSMF1, PSMB7, POMP, PSMB6, PSMB2, PSMD12, PSMA1, PSMD2, PSMC6, PSMA6, PSMA3, PSMB1, PSMA7, PSMC3, PSMB5, PSMA2, PSMA8, PSMB10, PSMB4, PSMC4, PSMD3, PSMC1, PSME2, PSMD13, PSMD11, PSME1, PSMA4, PSMD4, PSMC2, PSMC5, PSMD6, PSMD1, PSME3, PSMD8, PSMD7, PSMB8, SEM1, PSMD14, PSMB3, PSMB9",0.00700490156865849,0,FALSE +"H2126","Input","KEGG_PROTEIN_EXPORT",0.66921,1.91,0.0174,2359,0.17,"SRPRB, SRPRA, SEC62, SRP19, SRP54, SEC11C, SRP68, SRP72, SPCS2, SEC61B, SEC61A1, SPCS3, OXA1L",1.7594507517174,0.769551078621726,TRUE +"H2126","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.66755,-2.07,0.0157,8416,0.311,"PCK2, CA2, GLS, GLS2",1.80410034759077,0.507239610973163,FALSE +"H2126","Input","KEGG_PURINE_METABOLISM",0.33619,0.975,0.456,1077,0.731,"PDE4D, ADCY5, PAPSS2, CANT1, FHIT, ENPP1, NME3, RRM2, PRPS1, PRPS1L1, NT5C2, PDE5A, NME1, ADA, NUDT5, GDA, PRPS2, AK1",0.341035157335565,0.13608262304214,FALSE +"H2126","Input","KEGG_PYRIMIDINE_METABOLISM",0.22053,0.634,0.923,1150,1,"CANT1, CMPK1, CDA, NME3, RRM2, TYMP, TXNRD2, NT5C2, NME1, TXNRD1, CTPS1",0.0347982989740879,0,FALSE +"H2126","Input","KEGG_PYRUVATE_METABOLISM",-0.29274,-0.902,0.532,8021,0.906,"PKM, LDHB, ME3, ALDH9A1, PCK2, ACSS1",0.274088367704952,0.0428718023231869,FALSE +"H2126","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.23371,-0.738,0.796,7257,1,"IQGAP2, ABI2, VAV1, ARHGEF7, PAK3, MOS, MSN, ITGA3, CFL2, ENAH, FGD1, RRAS2, ITGB8, FGF13, FGF2, ARPC1A, PAK2, ITGA2B, SCIN, FN1, ITGA2, WAS, FGFR2, ITGA6, ACTN1, ITGA10, ITGB4, WASF1, PIK3R3, ACTG1, MYLK, ITGB3",0.0990869322623309,0,FALSE +"H2126","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.39457,1.15,0.266,1098,0.537,"PRKAA1, PRKAA2, ATG4C",0.575118363368933,0.270025714300444,FALSE +"H2126","Input","KEGG_RENAL_CELL_CARCINOMA",-0.26041,-0.814,0.688,8261,1,"PAK2, FH, TGFB2, JUN, FLCN, PIK3R3",0.162411561764489,0,FALSE +"H2126","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.61812,-1.93,0.0202,7585,0.433,"LNPEP, ANPEP, ACE",1.69464863055338,0.363512103646635,FALSE +"H2126","Input","KEGG_RETINOL_METABOLISM",-0.40012,-1.24,0.194,7759,0.685,"ADH4, ADH7, ADH1C, DHRS9, ALDH1A2, CYP3A7",0.712198270069774,0.164309428507574,FALSE +"H2126","Input","KEGG_RIBOFLAVIN_METABOLISM",0.57825,1.67,0.044,876,0.2,"PHPT1, ENPP1, RFK, ACP6",1.35654732351381,0.698970004336019,TRUE +"H2126","Input","KEGG_RIBOSOME",0.37424,1.08,0.317,3841,0.614,"RPL37, RPL35, RPL7A, RPL14, RPL18, RPS29, RPL38, RPL29, RPL18A, RPL22, RPL13A, RPS9, RPL36, RPL34, RPL7, RPL10A, RPS5, RPS16, RPL26, RPL23A, RPLP2, RPL30, RPS11, RPL37A, RPS15, RPS18, RPS3, RPL10, RPL15, RPS27A, RPL3, RPL28, RPL6, RPL17, RPL27, RPL35A, RPS13, RPS2, RPS12, UBA52, RPL9, RPS27L, RPS3A, RPS10, RPL19, RPS4X, RPS15A, RPS24, RPS8, RPS17, FAU, RPS25",0.498940737782249,0.211831628858832,FALSE +"H2126","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.16254,-0.501,0.989,7873,1,"DDX58, AZI2, CYLD, ISG15",0.0048037084028206,0,FALSE +"H2126","Input","KEGG_RNA_DEGRADATION",-0.30221,-0.924,0.523,5684,0.94,"TENT4A, PARN, C1D, LSM3, LSM7, EXOSC1, EXOSC7, EXOSC5, EXOSC8, EXOSC4, EXOSC3, HSPD1, PNPT1, LSM8, DCPS, LSM2, EXOSC2, DCP2, LSM6, MPHOSPH6, ENO2, DCP1B",0.281498311132726,0.0268721464003014,FALSE +"H2126","Input","KEGG_RNA_POLYMERASE",-0.24479,-0.753,0.763,2161,1,"POLR3K, POLR3B, POLR3C, POLR3F, POLR2I, POLR3GL, POLR3A, POLR3H, POLR3D, POLR2C, POLR2B, POLR1C, POLR1D, POLR1A, POLR1B, POLR2H, POLR2J, POLR3G, POLR1E, POLR2K, POLR2D, POLR2A, POLR2L, POLR2E, POLR2G, POLR2F",0.11747546204512,0,FALSE +"H2126","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.4481,1.3,0.153,478,0.424,"PAPSS2, BUD23, CTH, METTL2B",0.815308569182401,0.372634143407267,FALSE +"H2126","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.3302,-1.01,0.375,7663,0.785,"LAMB3, LAMC2, LAMA2, COL4A2, LAMB2, LAMC1, BCL2L1, MYC, ITGA2B, CCND1, FN1, ITGA2, ITGA6, PIAS2, TP53, CDK6, PIK3R3, COL4A1",0.425968732272281,0.105130343254747,FALSE +"H2126","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.36545,1.06,0.352,2249,0.626,"STX16, SEC22B, YKT6, VAMP7, BNIP1, BET1L, STX18, SNAP47, VAMP3, VTI1B, SNAP23, GOSR1, SNAP29",0.453457336521869,0.20342566678957,FALSE +"H2126","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.3853,-1.18,0.228,8038,0.629,"GLB1, KDSR, SMPD1, PLPP1, UGT8",0.642065152999546,0.201349354554731,FALSE +"H2126","Input","KEGG_SPLICEOSOME",-0.36522,-1.12,0.292,5534,0.688,"RBM8A, SF3B5, SNRPD1, SNRPD2, HNRNPU, ACIN1, SNRPG, PQBP1, SRSF5, SRSF6, PRPF18, LSM3, LSM7, SRSF10, WBP11, PPIL1, RBMX, HNRNPC, SNRPC, SF3B6, SRSF1, MAGOHB, ALYREF, SRSF7, TCERG1, SNRNP27, PRPF31, RBM25, SF3B3, ISY1, SF3A3, U2AF2, SRSF3, ZMAT2, CTNNBL1, SNRPB, DDX39B, SRSF2, EFTUD2, SNRPF, BUD31, SRSF8, CWC15, LSM8, SNW1, PLRG1, PRPF38A, DDX42, LSM2, SMNDC1, HNRNPA1, SYF2, TRA2B, SNU13, BCAS2, RBM17, EIF4A3, PRPF40A, RBM22, SLU7, SNRNP40, CDC5L, SRSF4, HNRNPA3, U2SURP, CDC40, HNRNPM, LSM6, PRPF19, TRA2A, HNRNPK, TXNL4A",0.534617148551582,0.162411561764489,FALSE +"H2126","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.60943,1.75,0.031,1343,0.201,"ENPP1, GYS1, PYGL, UGDH, UXS1, HK1, PYGM, PGM2, PGM2L1, PGM1",1.50863830616573,0.696803942579511,TRUE +"H2126","Input","KEGG_STEROID_BIOSYNTHESIS",0.62732,1.8,0.0163,831,0.245,"MSMO1, DHCR24, SC5D, NSDHL, FDFT1, DHCR7",1.78781239559604,0.610833915635468,TRUE +"H2126","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.55637,1.63,0.0421,521,0.223,"SULT2B1, SRD5A3, CYP1B1, COMT, CYP21A2",1.37571790416433,0.651695136951839,TRUE +"H2126","Input","KEGG_SULFUR_METABOLISM",0.78472,2.28,0,216,0.0466,"SULT2B1, SULT1A3, PAPSS2",Inf,1.33161408331,TRUE +"H2126","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.49155,-1.49,0.0836,7521,0.594,"SSB, TRIM21, C1S, ACTN1, C3, C1R",1.07779372256098,0.226213555018806,FALSE +"H2126","Input","KEGG_TASTE_TRANSDUCTION",0.32059,0.923,0.528,209,0.802,"CACNA1A",0.277366077466188,0.0958256317158365,FALSE +"H2126","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.59573,1.73,0.0307,1468,0.189,"IDI1, PDSS2, FDPS, MVD, PMVK, MVK, HMGCR",1.51286162452281,0.723538195826756,TRUE +"H2126","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.2805,-0.876,0.593,6878,0.92,"CREBBP, SMAD4, SMAD1, RBL1, BMPR2, SMAD3, ACVR2A, TGFBR2, MYC, TGFB2, INHBA, FST, THBS1, THBS2",0.226945306635737,0.0362121726544447,FALSE +"H2126","Input","KEGG_THYROID_CANCER",-0.35137,-1.08,0.295,7959,0.719,"TPR, TCF7L2, MYC, CCND1, TP53",0.530177984021837,0.143271109617117,FALSE +"H2126","Input","KEGG_TIGHT_JUNCTION",0.26989,0.774,0.749,1863,1,"CLDN3, MYH3, CLDN7, EPB41L3, EPB41L1, TJP3, RAB13, CGN, CTNNA1, LLGL2, PRKCD, AMOTL1, CTNNA2, VAPA, OCLN, F11R, PATJ, EXOC4, AKT1, CTTN",0.125518182300534,0,FALSE +"H2126","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.18618,-0.58,0.983,7601,1,"TOLLIP, TLR3, SPP1, IFNAR1, MAP2K6, JUN, CCL5, PIK3R3, CTSK",0.00744648216786438,0,FALSE +"H2126","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.44076,-1.34,0.168,7325,0.657,"CYP1A1, WARS2, ALDH1B1, ALDH9A1, GCDH, KYNU, MAOB",0.774690718274137,0.182434630440219,FALSE +"H2126","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.26787,0.769,0.754,1039,0.999,"CACNA1A, IRS2, PRKCD, HK1, PDX1",0.122628654130226,0.000434511774017692,FALSE +"H2126","Input","KEGG_TYROSINE_METABOLISM",0.53264,1.54,0.059,487,0.3,"HGD, ALDH3B1, COMT, BUD23, ALDH1A3, METTL2B, GSTZ1",1.22914798835786,0.522878745280338,FALSE +"H2126","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.17534,-0.548,0.985,8256,1,"PTPRC, PAK2, NFAT5, JUN, PIK3R3, NFATC2",0.00656376950238827,0,FALSE +"H2126","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.23048,0.672,0.883,3037,1,"FZR1, ANAPC11, SYVN1, MID1, UBE2Q1, BIRC2, PIAS3, HERC1, UBE4A, SMURF1, UBE2M, UBA7, RNF7, UBE2L3, XIAP, RCHY1, BRCA1, PPIL2, UBE2NL, CUL4A, CDC26, CUL4B, UBE2J1, UBE3C, MGRN1, UBE2N, NEDD4, CDC23, ANAPC4, CUL2, UBE2G2, UBE2A, CDC16, STUB1, ANAPC5, HERC4, ELOC, ITCH, UBE2G1, UBE2F, BIRC6, CUL1, TRIP12, TRIM37, ELOB, CBL, CUL7, UBE2Z, CUL3, HERC2, UBE2C, UBE2D2",0.0540392964224314,0,FALSE +"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.34285,-1.05,0.345,6260,0.746,"PDHA1, PDHB, LARS2, BCAT1",0.462180904926726,0.127261172527331,FALSE +"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.34823,-1.08,0.319,7932,0.719,"ACADSB, ALDH9A1, ACAA2, HMGCS2, BCAT1, OXCT1, IVD",0.496209316942819,0.143271109617117,FALSE +"H2126","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.33844,0.963,0.475,1500,0.743,"ITPR1, ADCY5, PLA2G12A, PLA2G4A, CACNA1F, PRKCD, MYL6, GNA11, ROCK1",0.323306390375133,0.129011186239425,FALSE +"H2126","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.20693,0.594,0.962,2718,0.993,"AQP3, ARHGDIB, RAB11A, NSF, RAB11B, DCTN5, DYNC1LI2, DYNC1H1, RAB5B",0.0168249279621871,0.00305075150461883,FALSE +"H2126","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.23268,0.666,0.897,2337,1,"PLA2G12A, CASP9, PLA2G4A, RAC2, PXN, RAC3, CHP1, MAPK13, RAC1, AKT1, MAPK3, HSPB1, SPHK2, MAPK12",0.0472075569559079,0,FALSE +"H2126","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.24131,0.699,0.847,1995,1,"KDELR3, TCIRG1, PDIA4, ERO1A, KDELR1, SEC61B, ATP6V0A1, ATP6V0D1, ATP6V1B1, ATP6V0C",0.0721165896692931,0,FALSE +"H2126","Input","KEGG_VIRAL_MYOCARDITIS",0.38191,1.11,0.287,528,0.597,"MYH3, CASP9, CD40, ITGB2, RAC2, BID",0.542118103266008,0.224025668870631,FALSE +"H2126","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.30079,-0.923,0.44,6878,0.923,"CREBBP, SMAD4, CACYBP, SIAH1, CTBP2, PLCB2, PLCB3, CAMK2D, WNT5A, TBL1X, TBL1XR1, LRP6, SMAD3, PRKCB, FZD1, TCF7L2, CAMK2B, MYC, FOSL1, NFAT5, CCND1, JUN, FZD7, TP53, NFATC2, CAMK2G",0.356547323513813,0.0347982989740879,FALSE +"H3255","Input","KEGG_ABC_TRANSPORTERS",-0.34284,-1.04,0.379,9404,0.817,"ABCA1, ABCB4, ABCD1, ABCG2",0.421360790031928,0.0877779434675845,FALSE +"H3255","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.22699,0.685,0.885,2513,0.936,"CEBPA, CCND1, RUNX1, BAD, TCF7L1, STAT3, RARA, IKBKG, HRAS, AKT1, TCF7L2, PIK3R3, IKBKB",0.0530567293021746,0.0287241512618947,FALSE +"H3255","Input","KEGG_ADHERENS_JUNCTION",0.2297,0.702,0.873,957,0.925,"EGFR, LMO7, FGFR1, NECTIN4, EP300, AFDN, ERBB2, CTNNB1",0.0589857562944303,0.0338582672609674,FALSE +"H3255","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.18008,-0.551,0.989,7785,1,"JAK2, CPT1C, PTPN11, ACACB, TRAF2, CAMKK2, SLC2A1, MAPK8, MAPK10, PRKCQ, IRS2",0.0048037084028206,0,FALSE +"H3255","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.32832,-0.989,0.397,9035,0.827,"ABAT, NIT2, GFPT2, GLUD2",0.401209493236885,0.0824944904474534,FALSE +"H3255","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.31997,-0.972,0.438,8484,0.807,"PIK3CB, SFN, ATP1B3, IRS2",0.3585258894959,0.0931264652779296,FALSE +"H3255","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.45433,1.38,0.11,71,0.598,"FADS2, PLA2G4A",0.958607314841775,0.223298816011589,FALSE +"H3255","Input","KEGG_ALZHEIMERS_DISEASE",-0.15801,-0.463,0.998,6846,1,"GSK3B, NDUFA9, CASP3, PLCB3, ATP5F1A, NDUFS2, NDUFB7, UQCR10, UQCRQ, MAPK3, CASP9, CHP1, ATP5F1C, GNAQ, GRIN1, NAE1, PLCB2, ATF6, ATP5F1E, CAPN1, ATP5PB, CASP7, PPP3CC, CYC1, PLCB4, NDUFA2, MAPT, LPL, IDE, LRP1, PSEN2, FADD, CACNA1F, SNCA",0.000869458712628891,0,FALSE +"H3255","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.47743,-1.46,0.105,8698,0.768,"LARS2, DARS2, WARS2, SEPSECS, CARS2",0.978810700930062,0.114638779968488,FALSE +"H3255","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.29991,-0.902,0.508,8555,0.847,"GNPDA1, GPI, FPGT, PGM2, GNE, UAP1, GFPT2, PGM1, GALK2",0.294136287716081,0.0721165896692931,FALSE +"H3255","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.40337,-1.23,0.205,9454,0.664,"MAP2K6, NEFL, PRPH, PRPH2, NEFH, TP53",0.688246138944246,0.177831920631982,FALSE +"H3255","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.25406,-0.765,0.732,8500,0.876,"RFX5, CTSL, HSP90AB1, RFXAP, HSPA2, NFYA, CD74",0.135488918941608,0.0574958938319193,FALSE +"H3255","Input","KEGG_APOPTOSIS",-0.29435,-0.871,0.569,7123,0.854,"BAX, EXOG, CASP9, RELA, CHP1, CHUK, TNFRSF10C, DFFB, IRAK1, XIAP, CAPN1, DFFA, TRAF2, IRAK3, CASP7, PIK3CB, PPP3CC, ATM, IRAK2, IRAK4, BIRC2, TNFRSF10B, TNFRSF10D, FADD, TP53",0.244887733604929,0.068542129310995,FALSE +"H3255","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.40376,1.21,0.239,279,0.495,"GGT5, PTGS2, PLA2G4A, GGT1",0.621602099051862,0.305394801066431,FALSE +"H3255","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.40906,1.24,0.203,1416,0.553,"ARG2, PRODH, PRODH2, ODC1, ALDH2, PYCR1, GLUL, GAMT, ALDH3A2, GLS, GLS2, OAT, MAOA, PYCR2, CKB, ALDH4A1",0.692503962086787,0.257274868695302,FALSE +"H3255","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.58775,-1.78,0.0344,8939,0.763,"SLC8A1, CACNA2D1, ITGB3, LEF1, ITGB1, CDH2, CACNA1F, ITGA5, ITGB8, ITGA6, DES, DSC2, DSG2",1.46344155742847,0.11747546204512,FALSE +"H3255","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.3471,1.09,0.313,1816,0.649,"ALDH2, ALDH3A2, UGDH",0.504455662453552,0.187755303199631,FALSE +"H3255","Input","KEGG_AXON_GUIDANCE",-0.28258,-0.869,0.61,8086,0.846,"PAK2, SRGAP2, SRGAP3, PAK3, SEMA5A, FYN, EPHB6, SRGAP1, NCK1, EFNA5, GNAI2, PPP3CC, RAC2, EFNB2, NCK2, CXCR4, RASA1, NFATC1, ABLIM3, SEMA7A, ITGB1, NFAT5, L1CAM, SEMA3F, EFNB1, ROBO1",0.214670164989233,0.0726296369609765,FALSE +"H3255","Input","KEGG_BASAL_CELL_CARCINOMA",-0.62416,-1.88,0.0156,9283,0.971,"LEF1, FZD7, WNT10A, WNT7A, GLI2, TP53",1.80687540164554,0.0127807700919951,FALSE +"H3255","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.12719,-0.376,1,7915,1,"TBPL1, GTF2F2, GTF2F1, GTF2B",0,0,FALSE +"H3255","Input","KEGG_BASE_EXCISION_REPAIR",0.24011,0.729,0.783,2064,0.924,"LIG3, POLE2, POLE4, XRCC1, POLE, POLE3, POLB, POLD4",0.106238237942057,0.0343280287798933,FALSE +"H3255","Input","KEGG_BETA_ALANINE_METABOLISM",-0.29132,-0.866,0.6,8443,0.83,"SRM, ABAT, ALDH1B1, ALDH7A1",0.221848749616356,0.0809219076239261,FALSE +"H3255","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.42747,1.28,0.161,1479,0.602,"FADS2, ACAA1, ACOT2, PECR, HSD17B12, SCD5, ACOX1",0.79317412396815,0.220403508742175,FALSE +"H3255","Input","KEGG_BLADDER_CANCER",-0.29424,-0.881,0.579,8246,0.857,"TYMP, RASSF1, MMP1, MAP2K1, RAF1, ARAF, CDKN2A, TP53",0.237321436272564,0.0670191780768018,FALSE +"H3255","Input","KEGG_BUTANOATE_METABOLISM",0.3346,1.02,0.377,1824,0.727,"OXCT1, ALDH2, HMGCS1, ALDH3A2, ALDH5A1, ACAT2, BDH2, EHHADH",0.423658649794207,0.138465589140962,FALSE +"H3255","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.4408,-1.32,0.137,8461,0.664,"SOS1, PIK3CB, PPP3CC, RAC2, BCL10, INPP5D, MAP2K1, RAF1, NFATC1, CARD11, MALT1, BLNK, NFAT5, CD79A, PLCG2, CD79B",0.863279432843593,0.177831920631982,FALSE +"H3255","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.23461,-0.705,0.823,8456,0.94,"F2R, CD38, PPP3CC, PHKA1, PLCB4, ATP2B2, ATP2B4, PHKB, SLC8A1, BST1, PHKG2, TRPC1, MYLK, PDE1C, CACNA1F, PLCD3, PLCG2",0.0846001647877302,0.0268721464003014,FALSE +"H3255","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.32017,-0.972,0.437,8541,0.807,"CYC1, ATP1B3, SLC8A1, CACNA2D1, CACNA1F, TPM2",0.359518563029578,0.0931264652779296,FALSE +"H3255","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.30421,0.954,0.504,1197,0.782,"ICAM1, SDC2, CLDN3, VCAN, CADM1, SDC1, CDH15, CDH3, OCLN, CLDN4, SDC3",0.297569463554475,0.106793246940152,FALSE +"H3255","Input","KEGG_CELL_CYCLE",-0.25617,-0.783,0.748,8299,0.863,"ESPL1, CDK2, YWHAQ, CDC26, PLK1, ATM, CHEK1, SMC1B, SFN, CDK1, CDKN2C, YWHAZ, TFDP1, TFDP2, TGFB2, CDKN2A, ORC3, TP53",0.126098402135539,0.0639892042847904,FALSE +"H3255","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.29396,-0.879,0.552,8412,0.849,"GNAI2, CXCL5, SOS1, PIK3CB, GRK6, RAC2, BCAR1, CCR4, CXCR4, PLCB4, SHC4, MAP2K1, CSK, RAF1, ELMO1, DOCK2, WAS, CCR10, CCR9, RASGRP2",0.258060922270801,0.0710923097560473,FALSE +"H3255","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.29429,-0.903,0.538,7990,0.857,"PTPN11, SHC1, CBLB, SOS1, PIK3CB, STAT5A, SHC4, MAP2K1, RAF1, ARAF, TGFB2, CDKN2A, CBL, TP53",0.269217724333611,0.0670191780768018,FALSE +"H3255","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.26201,0.802,0.705,2625,0.916,"CRY1, CLOCK, PER1, ARNTL",0.151810883008601,0.0381045263321496,FALSE +"H3255","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.40662,1.26,0.173,2829,0.561,"DLST, ACO1, MDH2, SDHA, OGDHL, OGDH, IDH2, IDH1, SUCLG2, PCK2, DLD, SUCLG1",0.761953896871205,0.251037138743839,FALSE +"H3255","Input","KEGG_COLORECTAL_CANCER",-0.42461,-1.28,0.175,8484,0.667,"PIK3CB, RAC2, APPL1, MAP2K1, RAF1, ARAF, MAPK8, LEF1, MAPK10, TGFB2, TP53, BIRC5",0.756961951313706,0.175874166083451,FALSE +"H3255","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.31916,0.987,0.415,1039,0.743,"PLAT, THBD, TFPI, PLAUR, CD55, C4A, F9, CFI, F8",0.381951903287907,0.129011186239425,FALSE +"H3255","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.35588,-1.08,0.326,6843,0.828,"ADI1, MAT1A, MAT2B, TAT, APIP, GOT2, MAT2A, AHCY, AHCYL1, SDS, SRM, MTAP",0.486782399932061,0.0819696632151199,FALSE +"H3255","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.27157,0.844,0.664,1302,0.877,"LIFR, EGFR, OSMR, CSF1, TGFB1, CCL28, TNFRSF21, IL1R1, IFNGR1, IL25, VEGFA, LTBR, TNFRSF19, TNFRSF1A, IL1RAP",0.177831920631982,0.0570004066339595,FALSE +"H3255","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.42134,-1.3,0.143,8691,0.679,"POLR3A, POLR3B, IL6, TBK1, ZBP1, IL18, PYCARD, TREX1",0.844663962534938,0.168130225719498,FALSE +"H3255","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.47347,-1.44,0.11,8939,0.713,"SLC8A1, CACNA2D1, ITGB3, ITGB1, TGFB2, CACNA1F, ITGA5, TPM2, ITGB8, ITGA6, DES",0.958607314841775,0.146910470148134,FALSE +"H3255","Input","KEGG_DNA_REPLICATION",0.39988,1.23,0.204,3839,0.53,"SSBP1, POLE2, POLE4, RPA3, POLE, POLE3, POLD4, RFC3, LIG1, MCM4, MCM3, RFC1, MCM6, POLA2, PCNA, MCM7, PRIM1",0.690369832574101,0.275724130399211,FALSE +"H3255","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.34053,-1.06,0.339,8461,0.821,"SOS1, NOTCH2, MAP2K1, ETS1, NOTCH1",0.469800301796918,0.0856568428805592,FALSE +"H3255","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.48669,-1.45,0.095,8919,0.738,"ALDH3B1, GSTM3, GSTM2, ALDH1A3, GSTM1, GSTO1, ALDH3A1, GSTM4, GSTP1",1.02227639471115,0.131943638176958,FALSE +"H3255","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.3388,-1,0.429,7770,0.833,"UMPS, CES1, CES2, TYMP, GMPS, HPRT1, IMPDH2, UCK2, CDA",0.367542707815276,0.0793549985932124,FALSE +"H3255","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.43397,-1.35,0.136,8767,0.726,"COL5A2, COL6A2, HSPG2, COL3A1, ITGB3, COL6A1, VTN, COL5A1, ITGB1, LAMA3, LAMA4, ITGA5, COL4A1, ITGB8, COL1A2, COL4A6, ITGA6, COL4A2",0.866461091629782,0.139063379299906,FALSE +"H3255","Input","KEGG_ENDOCYTOSIS",-0.26473,-0.794,0.715,7952,0.852,"STAM, DNM2, RAB11A, PIP4K2B, CHMP2A, PSD, EHD2, CBLB, WWP1, VTA1, F2R, EHD1, PDCD6IP, GRK6, IGF1R, SH3GLB1, EHD3, ASAP1, CHMP2B, CXCR4, DNM1L, EHD4, ARAP2, VPS4B, SH3GLB2, SNF8, GIT2, ASAP2, HSPA2, VPS36, RAB11FIP2, PIP5K1A, ACAP2, CBL, DNM1, DAB2",0.145693958198919,0.0695604052332999,FALSE +"H3255","Input","KEGG_ENDOMETRIAL_CANCER",-0.27938,-0.827,0.651,8461,0.816,"SOS1, PIK3CB, ILK, MAP2K1, RAF1, ELK1, ARAF, LEF1, TP53",0.186419011431808,0.0883098412461389,FALSE +"H3255","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.19706,-0.607,0.951,8738,1,"HBEGF, CSK, MAPK8, MAP2K4, MAPK10, PLCG2",0.0218194830625861,0,FALSE +"H3255","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.29974,-0.903,0.526,8052,0.857,"SHC1, PAK2, PAK3, ABL2, CBLB, NCK1, SOS1, PIK3CB, NCK2, HBEGF, MAP2K7, STAT5A, SHC4, MAP2K1, RAF1, ELK1, ARAF, MAPK8, MAP2K4, MAPK10, CBL, PLCG2",0.279014255846261,0.0670191780768018,FALSE +"H3255","Input","KEGG_ETHER_LIPID_METABOLISM",0.39645,1.19,0.237,1097,0.513,"PLA2G4A, LPCAT2, PLPP1, PLA2G12A, PLPP2, PLD1, PAFAH2",0.625251653989896,0.289882634888184,FALSE +"H3255","Input","KEGG_FATTY_ACID_METABOLISM",0.35348,1.08,0.327,2499,0.652,"ALDH2, ACSL5, ECI2, ACAA1, GCDH, ALDH3A2, ACAT2, ACOX1, ACSL1, ACADSB, EHHADH, ACSL4, ACADVL, ECHS1, ACOX3",0.485452247339714,0.18575240426808,FALSE +"H3255","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.33913,-1.03,0.362,8221,0.808,"FYN, PLA2G2D, SOS1, PIK3CB, LAT, RAC2, MAP2K7, INPP5D, MAP2K1, RAF1, MAPK8, MAP2K4, MAPK10, MAP2K6, PLCG2, PLA2G6",0.441291429466834,0.0925886392254138,FALSE +"H3255","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.30258,-0.919,0.498,8331,0.874,"VASP, PIK3CB, LAT, RAC2, ASAP1, DNM1L, INPP5D, MAP2K1, RAF1, DOCK2, WAS, ASAP2, PIP5K1A, DNM1, PLCG2, PLA2G6",0.302770657240282,0.058488567365597,FALSE +"H3255","Input","KEGG_FOCAL_ADHESION",-0.41381,-1.26,0.168,7690,0.685,"RAC3, RAP1B, LAMB4, ZYX, FLNB, ITGA3, RAPGEF1, XIAP, SHC1, PAK2, COL6A3, PAK3, FYN, COL1A1, VASP, HGF, SOS1, PIK3CB, FLNA, ILK, IGF1R, RAC2, DIAPH1, VCL, BCAR1, COL5A2, DOCK1, COL6A2, SHC4, MAP2K1, RAF1, ELK1, COL3A1, BIRC2, ITGB3, MAPK8, COL6A1, VTN, MYLK, COL5A1, FLNC, MAPK10, ITGB1, LAMA3, LAMA4, CAV1, ITGA5, COL4A1, ITGB8, PARVB, COL1A2, COL4A6, ITGA6, CAV2, COL4A2",0.774690718274137,0.164309428507574,FALSE +"H3255","Input","KEGG_FOLATE_BIOSYNTHESIS",0.39984,1.23,0.213,2958,0.53,"GGH, ALPI, ALPP, ALPG, DHFR",0.671620396561262,0.275724130399211,FALSE +"H3255","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.2781,0.847,0.617,173,0.887,"FBP1, FBP2",0.209714835966758,0.0520763801682736,FALSE +"H3255","Input","KEGG_GALACTOSE_METABOLISM",-0.35333,-1.06,0.351,8632,0.821,"PGM2, PGM1, GALK2, PFKP",0.454692883534176,0.0856568428805592,FALSE +"H3255","Input","KEGG_GAP_JUNCTION",0.19907,0.617,0.951,1186,0.959,"EGFR, GUCY1A1, GJA1, PLCB1, ITPR1, MAPK7, ITPR3",0.0218194830625861,0.0181813928293364,FALSE +"H3255","Input","KEGG_GLIOMA",-0.38066,-1.15,0.261,8461,0.736,"SOS1, PIK3CB, IGF1R, SHC4, MAP2K1, RAF1, ARAF, CDKN2A, PLCG2, TP53",0.583359492661719,0.133122185662501,FALSE +"H3255","Input","KEGG_GLUTATHIONE_METABOLISM",0.34208,1.06,0.344,423,0.676,"GGT5, GSTA5, ODC1, GGT1, GCLC, MGST1",0.46344155742847,0.170053304058364,FALSE +"H3255","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.23401,-0.712,0.838,8741,0.939,"DGKD, LPL, ALDH1B1, ALDH7A1, GK2, AGPAT4",0.0767559813697235,0.0273344077338891,FALSE +"H3255","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.27066,0.814,0.709,2117,0.907,"PLA2G4A, LPCAT2, PEMT, GPD1L, PLPP1, PLA2G12A, PLPP2, PLD1, CHKB, LPGAT1, MBOAT1, LPCAT1, LYPLA2, LPCAT3, PLA2G15, GPD2, PLPP3, CDS1",0.149353764816933,0.0423927129399047,FALSE +"H3255","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.29789,0.943,0.495,1288,0.79,"PSPH, GCAT, GAMT, MAOA, CTH",0.305394801066431,0.102372908709559,FALSE +"H3255","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.32917,-1,0.421,8556,0.833,"GPI, PGM2, PGK1, ALDH3B1, PKM, ALDH1B1, PGAM1, PGAM4, ALDH1A3, PKLR, PGM1, ALDH7A1, PFKP, ALDH3A1",0.375717904164332,0.0793549985932124,FALSE +"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.34442,-1.03,0.375,8563,0.808,"CSGALNACT1, CHST13, CHST7, XYLT1, CHST3",0.425968732272281,0.0925886392254138,FALSE +"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.28566,0.878,0.557,2422,0.869,"HS6ST2, XYLT2, EXT2, GLCE, NDST1, B4GALT7",0.254144804826271,0.0609802235513335,FALSE +"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.4081,1.27,0.174,2980,0.568,"FUT8, B3GNT2, B4GALT3, B4GALT1, B4GAT1",0.7594507517174,0.245651664288981,FALSE +"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.58563,1.77,0.0302,1870,0.289,"SGSH, GUSB, GNS, HEXB, HEXA, NAGLU, HGSNAT",1.51999305704285,0.539102157243452,FALSE +"H3255","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.43302,-1.32,0.17,9836,0.664,"B4GALNT1",0.769551078621726,0.177831920631982,FALSE +"H3255","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.38661,1.21,0.226,1666,0.495,"FUT1, HEXB, HEXA, NAGA",0.645891560852599,0.305394801066431,FALSE +"H3255","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.41006,-1.25,0.178,9621,0.662,"ABO, B3GALT5",0.749579997691106,0.1791420105603,FALSE +"H3255","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.5379,1.65,0.049,2265,0.361,"PIGA, PIGH, PIGS, PIGO, PIGT, PIGK, GPAA1",1.30980391997149,0.442492798094342,FALSE +"H3255","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.43088,1.35,0.132,3361,0.586,"ACO1, MDH2, MTHFD1L, GRHPR, MTHFD1, CS",0.87942606879415,0.232102383981909,FALSE +"H3255","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.2673,-0.816,0.654,7175,0.818,"MAP2K2, MAPK3, PLA2G2A, MMP2, MAP3K3, ADCY3, ADCY8, PTK2B, GNAQ, ADCY9, SRC, PLCB2, MAP2K3, MAP3K2, PLA2G2D, SOS1, HBEGF, MAP2K7, PLCB4, MAP2K1, RAF1, ELK1, MAPK8, MAP2K4, MAPK10, MAP2K6, CACNA1F, MMP14, PLA2G6",0.184422251675733,0.087246696328677,FALSE +"H3255","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.57521,-1.75,0.023,9204,0.572,"CSNK1E, WNT10A, WNT7A, GLI2",1.63827216398241,0.242603971206976,FALSE +"H3255","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.33087,-0.993,0.442,8470,0.833,"CD38, CD59, CD14, IL6, ITGB3, ITGA5, ANPEP, ITGA6, CD33",0.354577730650908,0.0793549985932124,FALSE +"H3255","Input","KEGG_HISTIDINE_METABOLISM",-0.38446,-1.15,0.272,8384,0.736,"LCMT1, MAOB, ALDH3B1, ALDH1B1, ALDH1A3, ALDH7A1, LCMT2, ALDH3A1",0.565431095965801,0.133122185662501,FALSE +"H3255","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.23296,-0.7,0.826,8074,0.937,"RAD54B, BRCA2, RAD51, TOP3B, RAD52",0.0830199526796178,0.0282604091122217,FALSE +"H3255","Input","KEGG_HUNTINGTONS_DISEASE",-0.1595,-0.475,0.996,6266,1,"COX7B, NDUFA10, NDUFB3, GPX1, NDUFS1, SDHD, ATP5PO, NDUFA7, COX7C, NDUFB2, NDUFC2, DNAL4, SLC25A4, NDUFA9, CASP3, PLCB3, ATP5F1A, DNAL1, NDUFS2, NDUFB7, BAX, UQCR10, UQCRQ, CASP9, SLC25A5, ATP5F1C, GNAQ, GRM5, GRIN1, PLCB2, HTT, DCTN2, TBPL1, ATP5F1E, SP1, ATP5PB, SOD1, PPARG, CYC1, DCTN4, DCTN1, PLCB4, NDUFA2, CREB5, TGM2, TP53",0.00174066157630127,0,FALSE +"H3255","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.52789,-1.65,0.0564,8939,0.64,"SLC8A1, IL6, CACNA2D1, ITGB3, ITGB1, TGFB2, CACNA1F, ITGA5, TPM2, ITGB8, ITGA6, DES, ACE",1.24872089601666,0.193820026016113,FALSE +"H3255","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.29939,-0.904,0.53,8484,0.881,"PIK3CB, INPP1, PIK3C3, ITPK1, PLCB4, INPPL1, IMPA1, PIP5K1A, PLCD3, PLCG2",0.275724130399211,0.0550240915879521,FALSE +"H3255","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.28823,-0.857,0.588,7895,0.807,"EIF4EBP1, RAPGEF1, SHC1, PHKA2, FOXO1, CBLB, ACACB, RPS6, SOS1, PIK3CB, PHKA1, PHKB, SHC4, INPP5D, MAP2K1, RAF1, ELK1, PHKG2, ARAF, MAPK8, PKLR, MAPK10, MKNK1, CBL, SOCS4, IRS2",0.230622673923862,0.0931264652779296,FALSE +"H3255","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.50237,-1.55,0.0691,8733,0.73,"CXCR4, IL6, CCR10, CCR9, CD40",1.1605219526258,0.136677139879544,FALSE +"H3255","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.29048,0.885,0.593,1009,0.87,"LIFR, OSMR, CCND1, SPRY2, STAM2, EP300, IFNGR1, STAT2, PIAS3",0.226945306635737,0.0604807473813815,FALSE +"H3255","Input","KEGG_LEISHMANIA_INFECTION",0.3775,1.14,0.26,787,0.585,"PTGS2, MYD88, MAPK12, TGFB1, TLR2, MAPK13, IFNGR1",0.585026652029182,0.23284413391782,FALSE +"H3255","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.23998,0.738,0.824,1123,0.936,"ICAM1, CLDN3, MAPK12, MAPK13, VAV1, AFDN, ARHGAP35, CTNNB1, OCLN, CLDN4",0.0840727883028842,0.0287241512618947,FALSE +"H3255","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.32649,1.01,0.418,1824,0.73,"ALDH2, ALDH3A2, EHHADH",0.378823718224965,0.136677139879544,FALSE +"H3255","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.38646,-1.17,0.242,9884,0.733,"PLA2G6",0.616184634019569,0.134896025358872,FALSE +"H3255","Input","KEGG_LONG_TERM_DEPRESSION",0.2406,0.741,0.759,1186,0.945,"PLA2G4A, GUCY1A1, GNAO1, PLCB1, ITPR1, PLA2G12A, ITPR3",0.11975822410452,0.0245681914907371,FALSE +"H3255","Input","KEGG_LONG_TERM_POTENTIATION",0.16611,0.516,0.989,1186,0.992,"EP300, PLCB1, ITPR1, ATF4, PPP3R1, ITPR3",0.0048037084028206,0.00348832784582135,FALSE +"H3255","Input","KEGG_LYSINE_DEGRADATION",0.274,0.834,0.616,1537,0.882,"ALDH2, AASS, DLST, GCDH, ALDH3A2, OGDHL, ACAT2, NSD3, OGDH, SETMAR",0.210419287835575,0.0545314148681803,FALSE +"H3255","Input","KEGG_LYSOSOME",0.59532,1.87,0.0175,1669,0.305,"CTSE, NPC2, NAPSA, LGMN, SGSH, CTSH, LAMP3, CTSC, FUCA1, GALC, PSAP, CTSZ, GUSB, CD63, NEU1, MANBA, ASAH1, GNS, ACP2, GNPTG, ARSA, SCARB2, SMPD1, MFSD8, CLN3, AGA, CLTA, ACP5, MAN2B1, CTSS, NAGPA, HEXB, SORT1, DNASE2, GM2A, HEXA, CTSA, GNPTAB, M6PR, SLC11A2, NAGA, MCOLN1",1.75696195131371,0.515700160653214,FALSE +"H3255","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.33904,-1.01,0.384,8461,0.84,"SOS1, ATF2, PPP3CC, FLNA, RAC2, STMN1, MAP2K7, NLK, CD14, RASA1, MAP2K1, MAPT, ELK4, RAF1, CACNA2D1, ELK1, DUSP4, DUSP1, MAPK8, PTPN7, MAP2K4, MAP4K4, NFKB2, FLNC, MAPK10, RELB, TGFB2, MAP2K6, HSPA2, CACNA1F, MKNK1, STK4, MOS, FGF13, FGF2, PLA2G6, RASGRP2, TP53",0.415668775632469,0.0757207139381184,FALSE +"H3255","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.2755,-0.827,0.646,9338,0.816,"PKLR",0.189767482004916,0.0883098412461389,FALSE +"H3255","Input","KEGG_MELANOGENESIS",-0.22541,-0.684,0.861,6728,0.951,"PRKCB, GNAI3, GSK3B, PLCB3, MAP2K2, MAPK3, ADCY3, ADCY8, GNAQ, ADCY9, PLCB2, DCT, FZD2, GNAI2, PLCB4, MAP2K1, RAF1, LEF1, FZD7, WNT10A, WNT7A",0.0649968485463452,0.0218194830625861,FALSE +"H3255","Input","KEGG_MELANOMA",-0.42238,-1.32,0.135,8460,0.664,"HGF, PIK3CB, IGF1R, MAP2K1, RAF1, ARAF, CDKN2A, FGF13, FGF2, TP53",0.869666231504994,0.177831920631982,FALSE +"H3255","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.42542,-1.29,0.157,8919,0.672,"ALDH3B1, GSTM3, GSTM2, ALDH1A3, GSTM1, GSTO1, ALDH3A1, GSTM4, GSTP1",0.804100347590766,0.172630726946175,FALSE +"H3255","Input","KEGG_MISMATCH_REPAIR",0.39045,1.21,0.189,3752,0.495,"SSBP1, RPA3, POLD4, RFC3, LIG1, RFC1, EXO1, MSH3, PCNA, PMS2",0.723538195826756,0.305394801066431,FALSE +"H3255","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.14959,-0.45,1,6026,1,"EIF4E2, AKT2, EIF4B, RPS6KA2, RPS6KB1, ULK3, RPS6KA1, MAPK3, TSC2, TSC1, EIF4EBP1, RPS6, PIK3CB, CAB39L",0,0,FALSE +"H3255","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.30955,-0.935,0.483,8461,0.85,"SOS1, PIK3CB, LAT, PPP3CC, LCK, RAC2, SHC4, MAP2K1, RAF1, SH3BP2, NFATC1, ARAF, TNFRSF10B, TNFRSF10D, ICAM2, NFAT5, PRF1, PLCG2",0.316052869248488,0.0705810742857073,FALSE +"H3255","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.35608,-1.07,0.355,7196,0.834,"PLG, GRM5, GRIN1, PRSS3, NR3C1, F2, F2R, F2RL1",0.449771646944906,0.0788339493622613,FALSE +"H3255","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.31831,-0.984,0.436,7848,0.823,"YWHAB, IRAK1, RAPGEF1, MAGED1, PTPN11, FOXO3, SHC1, YWHAQ, IRAK3, SOS1, PIK3CB, MAP2K7, RIPK2, SHC4, MAP2K1, IRAK2, CSK, YWHAZ, RAF1, IRAK4, MAPK8, MAPK10, PLCG2, NGFR, IRS2, TP53",0.360513510731414,0.0846001647877302,FALSE +"H3255","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.41951,1.27,0.168,364,0.568,"ENPP3, NAMPT, NT5E",0.774690718274137,0.245651664288981,FALSE +"H3255","Input","KEGG_NITROGEN_METABOLISM",-0.51133,-1.52,0.0813,9087,0.734,"CA9, CA12, GLUD2, CA2",1.08990945440593,0.134303940083929,FALSE +"H3255","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.40053,-1.19,0.246,7187,0.708,"MAPK3, RELA, CHUK, TAB1, CASP1, PYDC1, XIAP, CARD8, TAB3, HSP90AB1, RIPK2, IL6, BIRC2, MAPK8, TNFAIP3, MAPK10, SUGT1, IL18, PYCARD",0.609064892896621,0.149966742310231,FALSE +"H3255","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.46002,-1.38,0.109,6350,0.692,"DCLRE1C, RAD50, LIG4, POLL, NHEJ1, PRKDC, FEN1",0.962573502059376,0.159893905543242,FALSE +"H3255","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.35828,-1.1,0.294,8445,0.797,"RASSF1, SOS1, PIK3CB, MAP2K1, RAF1, ARAF, CDKN2A, STK4, PLCG2, TP53",0.531652669587843,0.0985416786038876,FALSE +"H3255","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.21185,0.652,0.923,3247,0.94,"NCOR2, EP300, HES1, DTX2, NOTCH3, CTBP1, HDAC2, MAML2, PSEN1, CREBBP, SNW1, DVL2, ADAM17, NUMB",0.0347982989740879,0.0268721464003014,FALSE +"H3255","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.29256,0.903,0.55,3699,0.846,"POLE2, POLE4, ERCC8, RPA3, MNAT1, POLE, DDB2, POLE3, POLD4, RFC3, GTF2H5, DDB1, LIG1, GTF2H2, RFC1, ERCC2, GTF2H1, PCNA, ERCC4, CDK7",0.259637310505756,0.0726296369609765,FALSE +"H3255","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.39376,1.22,0.201,1704,0.529,"FUT8, ST6GAL1, MGAT4A, MAN1A1, MGAT1, MAN2A2, MOGS, MAN1B1, ALG12, MGAT2, B4GALT3",0.696803942579511,0.276544327964814,FALSE +"H3255","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.2352,-0.722,0.831,7253,0.933,"ADCY3, CNGB1, PDE1C",0.080398976215889,0.0301183562535,FALSE +"H3255","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.31526,-0.948,0.482,7361,0.833,"MTFMT, GART, ATIC, MTHFR, ALDH1L1",0.31695296176115,0.0793549985932124,FALSE +"H3255","Input","KEGG_OOCYTE_MEIOSIS",-0.26299,-0.782,0.727,6083,0.854,"PRKACB, MAD2L2, CDC16, CDC23, RPS6KA2, PPP2CB, CDC20, ANAPC4, PPP2CA, MAD2L1, PPP1CB, SKP1, SMC3, SMC1A, RPS6KA1, MAPK3, ADCY3, ADCY8, PTTG1, SGO1, CHP1, PPP2R5A, ADCY9, CUL1, CDC25C, YWHAB, PPP2R5D, FBXO5, SLK, ESPL1, CDK2, YWHAQ, CDC26, PPP3CC, PLK1, IGF1R, SMC1B, CDK1, PPP2R1B, MAP2K1, YWHAZ, MOS",0.138465589140962,0.068542129310995,FALSE +"H3255","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.61298,1.86,0.0172,1326,0.227,"FUCA1, NEU1, MANBA, AGA, MAN2B1, HEXB, HEXA",1.76447155309245,0.643974142806877,TRUE +"H3255","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.19406,-0.568,0.965,5496,1,"NDUFB5, NDUFB9, NDUFS8, NDUFA3, NDUFC1, NDUFS5, NDUFS4, UQCRC2, NDUFV2, NDUFS7, COX4I1, NDUFB4, COX7A2L, UQCRC1, COX11, NDUFA6, NDUFV1, ATP6V1H, COX7B, NDUFA11, NDUFA10, NDUFB3, NDUFS1, SDHD, COX17, ATP5PO, NDUFA7, COX7C, NDUFB2, NDUFC2, ATP12A, NDUFA9, ATP5F1A, ATP6V1C1, NDUFS2, NDUFB7, UQCR10, UQCRQ, ATP5F1C, PPA1, ATP5MG, ATP5ME, ATP5F1E, COX15, TCIRG1, ATP5PB, CYC1, NDUFA2",0.0154726866562074,0,FALSE +"H3255","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.76427,2.39,0,1130,0.0609,"GALNT10, GALNT8, GALNT3, GALNT5, GALNT12, GALNT4, GALNT11, C1GALT1, GALNT6, C1GALT1C1, GALNT1, GALNT13, GALNT7",Inf,1.21538270736712,TRUE +"H3255","Input","KEGG_P53_SIGNALING_PATHWAY",-0.41325,-1.25,0.193,8360,0.662,"CDK2, IGFBP3, ATM, CHEK1, SFN, CDK1, RRM2B, PERP, TNFRSF10B, CDKN2A, SERPINE1, SERPINB5, TP53",0.714442690992226,0.1791420105603,FALSE +"H3255","Input","KEGG_PANCREATIC_CANCER",-0.28805,-0.866,0.623,8296,0.83,"RAD51, PIK3CB, ARHGEF6, RAC2, MAP2K1, RAF1, ARAF, MAPK8, MAPK10, TGFB2, CDKN2A, TP53",0.20551195334083,0.0809219076239261,FALSE +"H3255","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.64565,1.99,0.0167,1,0.419,"ENPP3",1.77728352885242,0.377785977033705,FALSE +"H3255","Input","KEGG_PARKINSONS_DISEASE",-0.27526,-0.827,0.656,5677,0.816,"NDUFC1, NDUFS5, NDUFS4, UQCRC2, NDUFV2, NDUFS7, UBE2L3, COX4I1, NDUFB4, COX7A2L, UQCRC1, NDUFA6, NDUFV1, SLC25A6, COX7B, NDUFA10, NDUFB3, NDUFS1, SDHD, ATP5PO, NDUFA7, COX7C, NDUFB2, NDUFC2, PARK7, SLC25A4, NDUFA9, CASP3, ATP5F1A, NDUFS2, NDUFB7, UQCR10, UQCRQ, CASP9, SLC25A5, ATP5F1C, ATP5F1E, SLC18A1, ATP5PB, CYC1, UBA1, NDUFA2, UCHL1, UBA7, SNCA",0.18309616062434,0.0883098412461389,FALSE +"H3255","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.31893,-0.969,0.437,8221,0.8,"FYN, NCK1, YWHAQ, TUBA3C, TUBB4B, NCK2, CD14, YWHAZ, TUBAL3, WAS, ITGB1, TUBB6",0.359518563029578,0.0969100130080564,FALSE +"H3255","Input","KEGG_PATHWAYS_IN_CANCER",-0.36469,-1.12,0.287,8201,0.788,"AXIN2, FZD2, CBLB, RAD51, VHL, CDK2, PPARG, TRAF2, RASSF1, HGF, SOS1, PIK3CB, TFG, IGF1R, RAC2, MMP1, APPL1, HSP90AB1, PAX8, STAT5A, MAP2K1, IL6, RAF1, SLC2A1, EGLN1, ARAF, BIRC2, MAPK8, LEF1, PML, NFKB2, ETS1, MAPK10, FADD, ITGB1, TGFB2, LAMA3, LAMA4, FZD7, WNT10A, CDKN2A, STK4, COL4A1, CBL, COL4A6, ITGA6, WNT7A, PLCG2, COL4A2, GLI2, FGF13, FGF2, GSTP1, TP53, BIRC5",0.542118103266008,0.103473782510445,FALSE +"H3255","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.62983,1.94,0.00818,1816,0.365,"GUSB, DCXR, AKR1B1, UGDH",2.08724669632868,0.437707135543525,FALSE +"H3255","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.29539,0.912,0.515,173,0.843,"FBP1, FBP2",0.288192770958809,0.0741724253752577,FALSE +"H3255","Input","KEGG_PEROXISOME",0.44275,1.34,0.161,2246,0.574,"AMACR, ACSL5, SLC27A2, ECI2, ACAA1, ECH1, CROT, PECR, DHRS4, PEX16, PXMP4, PEX13, ACOT8, DECR2, PEX6, ACOX1, PEX2, ACSL1, PEX3, IDH2, EHHADH, ACSL4, IDH1, SCP2, MPV17, GSTK1, MVK, PEX26, PEX1",0.79317412396815,0.241088107602027,FALSE +"H3255","Input","KEGG_PHENYLALANINE_METABOLISM",-0.51143,-1.56,0.0584,6281,0.784,"PRDX6, GOT1, MIF, TAT, GOT2, MAOB, ALDH3B1, ALDH1A3, ALDH3A1",1.2335871528876,0.105683937315562,FALSE +"H3255","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.29616,-0.887,0.577,7419,0.855,"PIP5K1C, DGKB, DGKQ, PI4KB, PLCB2, SYNJ2, PIP4K2B, DGKE, PIK3CB, INPP1, PIK3C3, ITPK1, DGKD, PLCB4, INPPL1, INPP5D, IMPA1, PIP5K1A, PLCD3, PLCG2",0.238824186844269,0.0680338852718274,FALSE +"H3255","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.36222,1.13,0.273,1507,0.587,"CP, GUSB, ALAD, BLVRA, HMOX1, CPOX",0.563837352959244,0.231361898752386,FALSE +"H3255","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.45538,-1.38,0.117,9042,0.692,"SLC27A1, FABP7, LPL, SCD, ACADL, GK2, CYP27A1, PLTP, FABP5, OLR1, ANGPTL4",0.931814138253838,0.159893905543242,FALSE +"H3255","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.56543,1.72,0.036,1022,0.307,"AMACR, AKR1D1, HSD3B7",1.44369749923271,0.512861624522813,FALSE +"H3255","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.59581,-1.77,0.0261,8500,0.629,"RFX5, LCK, RFXAP, BLNK, CD79A, CD40",1.58335949266172,0.201349354554731,FALSE +"H3255","Input","KEGG_PRION_DISEASES",-0.46458,-1.38,0.141,8221,0.692,"FYN, SOD1, MAP2K1, IL6, ELK1, PRNP, NOTCH1, NCAM1",0.85078088734462,0.159893905543242,FALSE +"H3255","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.32346,-0.982,0.427,8360,0.813,"CDK2, GNAI2, CDC26, PIK3CB, PLK1, IGF1R, HSP90AB1, CDK1, MAP2K1, RAF1, ARAF, MAPK8, MAPK10, MOS",0.369572124974976,0.0899094544059319,FALSE +"H3255","Input","KEGG_PROPANOATE_METABOLISM",0.31766,1,0.39,2228,0.732,"ALDH2, ALDH6A1, ALDH3A2, ACSS1, LDHB, ACAT2, ACSS2, EHHADH, HIBCH, PCCA, SUCLG2",0.408935392973501,0.135488918941608,FALSE +"H3255","Input","KEGG_PROSTATE_CANCER",-0.24203,-0.739,0.825,8360,0.913,"CDK2, SOS1, PIK3CB, IGF1R, HSP90AB1, MAP2K1, RAF1, ARAF, CREB5, LEF1, GSTP1, TP53",0.0835460514500749,0.039529222465701,FALSE +"H3255","Input","KEGG_PROTEASOME",-0.30056,-0.891,0.562,5469,0.859,"PSMD11, PSMB1, PSMA8, PSME3, PSMD8, PSMB4, PSMA7, PSMD13, PSMD7, PSME4, PSMA6, PSMA4, PSMD6, PSMD1, PSMB2, SEM1, PSME2, PSMD3, PSMD12, PSMB8, PSME1, POMP, PSMB10, PSMB9",0.250263684430939,0.0660068361687577,FALSE +"H3255","Input","KEGG_PROTEIN_EXPORT",0.24929,0.785,0.733,2140,0.92,"SRP9, SEC62, IMMP2L, SRP14, OXA1L",0.134896025358872,0.0362121726544447,FALSE +"H3255","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.47046,-1.41,0.131,9872,0.743,"GLUD2, CA2",0.882728704344236,0.129011186239425,FALSE +"H3255","Input","KEGG_PURINE_METABOLISM",0.27566,0.86,0.599,1176,0.876,"ENPP3, ENTPD3, GUCY1A1, ENTPD5, PDE4A, NME4, NT5E, FHIT, POLE2, POLE4, PAPSS2, PDE2A, ENTPD6, CANT1, ADCY10",0.222573177610689,0.0574958938319193,FALSE +"H3255","Input","KEGG_PYRIMIDINE_METABOLISM",0.25348,0.784,0.755,1136,0.907,"ENTPD3, ENTPD5, NME4, NT5E, TXNRD2, UPP1, POLE2, POLE4, UCK1, ENTPD6, CANT1, CTPS2",0.122053048370812,0.0423927129399047,FALSE +"H3255","Input","KEGG_PYRUVATE_METABOLISM",0.24477,0.763,0.758,1366,0.918,"ALDH2, ME1, ALDH3A2, ACSS1, MDH2, LDHB, ACAT2, ACSS2",0.120330794367946,0.0371573187987575,FALSE +"H3255","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.38963,-1.19,0.239,8086,0.708,"PAK2, PIP4K2B, MSN, ARHGEF7, PAK3, F2, F2R, SOS1, PIK3CB, ARHGEF6, RAC2, DIAPH1, VCL, BCAR1, NCKAP1, BAIAP2, CYFIP1, DOCK1, CD14, MAP2K1, CSK, RAF1, DIAPH3, ARAF, ITGB3, RDX, MYLK, WAS, ITGB1, PIP5K1A, ITGA5, MOS, DIAPH2, ITGB8, ITGA6, FGF13, FGF2, ARHGEF4",0.621602099051862,0.149966742310231,FALSE +"H3255","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.41874,-1.24,0.205,7595,0.663,"BECN1, GABARAPL1, PIK3C3, ATG3, GABARAPL2, ATG7",0.688246138944246,0.178486471595227,FALSE +"H3255","Input","KEGG_RENAL_CELL_CARCINOMA",-0.27462,-0.837,0.631,7685,0.837,"CUL2, RAP1B, RAPGEF1, PTPN11, PAK2, PAK3, VHL, HGF, SOS1, PIK3CB, MAP2K1, RAF1, SLC2A1, EGLN1, ARAF, ETS1, TGFB2",0.199970640755866,0.07727454200674,FALSE +"H3255","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.64205,-1.98,0.00975,9597,1,"ANPEP, CPA3, ACE",2.01099538430146,0,FALSE +"H3255","Input","KEGG_RETINOL_METABOLISM",0.27614,0.861,0.609,1532,0.891,"RDH11, DHRS3, DHRS4, CYP3A4",0.215382707367125,0.0501222959631252,FALSE +"H3255","Input","KEGG_RIBOFLAVIN_METABOLISM",0.6086,1.86,0.0252,904,0.227,"ENPP3, ACP2, ACP5",1.59859945921846,0.643974142806877,TRUE +"H3255","Input","KEGG_RIBOSOME",-0.59276,-1.78,0.0329,6387,0.763,"RPL37A, RPS4X, FAU, RPL24, RSL24D1, RPL23, RPS5, RPS19, RPL27, RPS15, RPL3, RPL21, RPS17, RPL29, RPL15, RPL23A, RPS8, RPL35, RPS3A, RPL30, RPS13, RPL35A, RPL8, RPL27A, RPL5, RPL32, RPS3, RPL18, RPL36A, RPL36AL, RPS9, RPL18A, RPS15A, RPS25, RPS7, RPL26, RPL38, RPL28, RPL6, RPS24, RPL22, RPL34, RPL17, RPS2, RPL11, RPL9, RPS18, RPL13A, RPL4, RPL31, RPS16, RPS29, RPS20, RPL19, RPL10A, RPS6, RPL14, RPS11, RPL37, RPL7A, RPS23, RPL7, UBA52, RPL36, RPS27L, RPS4Y1",1.48280410205003,0.11747546204512,FALSE +"H3255","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.21217,0.653,0.927,741,0.952,"MAPK12, IRF7, MAPK13, DDX58, CASP10",0.0329202658555029,0.0213630516155257,FALSE +"H3255","Input","KEGG_RNA_DEGRADATION",-0.35406,-1.1,0.321,6817,0.797,"CNOT4, CNOT9, PARN, DCP1A, CNOT7, EXOSC5, CNOT2, PAPOLG, EXOSC10, CNOT1, EXOSC3, DDX6, MTREX, ENO3, XRN1, CNOT6L, PATL1, EDC3, MPHOSPH6, CNOT6, DIS3, DCPS, C1D",0.493494967595128,0.0985416786038876,FALSE +"H3255","Input","KEGG_RNA_POLYMERASE",-0.19527,-0.583,0.96,1932,1,"POLR2J, POLR3GL, POLR1E, POLR3G, POLR2D, POLR2G, POLR2I, POLR2F, POLR2E, POLR2C, POLR2K, POLR2L, POLR2H, POLR1B, POLR1A, POLR2A, POLR3C, POLR1C, POLR1D, POLR2B, POLR3D, POLR3F, POLR3K, POLR3H, POLR3A, POLR3B",0.0177287669604316,0,FALSE +"H3255","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.43698,1.32,0.149,1288,0.552,"GGT5, GGT1, PAPSS2, TRMT11, CTH",0.826813731587726,0.258060922270801,FALSE +"H3255","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.34335,-1.05,0.37,9225,0.827,"BIRC2, ITGB1, LAMA3, LAMA4, COL4A1, COL4A6, ITGA6, COL4A2, TP53",0.431798275933005,0.0824944904474534,FALSE +"H3255","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.41183,1.25,0.185,1992,0.556,"VTI1B, GOSR2, STX16, STX8, BET1L, GOSR1, STX17, VAMP4, STX6, VAMP8, TSNARE1",0.732828271596986,0.254925208417942,FALSE +"H3255","Input","KEGG_SPHINGOLIPID_METABOLISM",0.48964,1.53,0.0807,908,0.39,"GALC, NEU1, ASAH1, ARSA, SMPD1, SGPP1, PLPP1, PLPP2",1.09312646527793,0.408935392973501,FALSE +"H3255","Input","KEGG_SPLICEOSOME",0.32927,1.04,0.38,3991,0.701,"HSPA6, ISY1, SRSF9, SF3B5, NCBP2, DDX42, DDX23, SRSF5, PRPF19, PRPF40A, SF3A1, TRA2A, SNRPG, PQBP1, HSPA1A, BCAS2, LSM2, PPIL1, HNRNPA1, CDC5L, SRSF8, SNRPB2, CDC40, SYF2, PPIE, PHF5A, PLRG1, SART1, WBP11, U2AF1, SRSF2, SRSF4, CCDC12, SNRNP200, LSM8, ACIN1, TRA2B, SNRPF, SRSF3, SNW1, HNRNPA3, SRSF1, TXNL4A, SRSF7, HSPA1L, SNRNP40, RBM8A, RBMX, PRPF6, HNRNPM, SNRPB, DDX5, EFTUD2, SF3B2, U2AF2, THOC3, RBM17, LSM7, HNRNPK, SNRPA1, SF3B3, XAB2, LSM6, SF3A3",0.42021640338319,0.154281982033341,FALSE +"H3255","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.4374,1.35,0.13,258,0.586,"ENPP3, GUSB",0.886056647693163,0.232102383981909,FALSE +"H3255","Input","KEGG_STEROID_BIOSYNTHESIS",0.63439,1.91,0.0164,2032,0.319,"DHCR24, DHCR7, LSS, TM7SF2, FDFT1, CYP27B1, CYP51A1, SOAT2, MSMO1, SC5D",1.7851561519523,0.496209316942819,FALSE +"H3255","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.49854,1.57,0.0497,1835,0.397,"SULT2B1, AKR1D1, SRD5A3, HSD11B2, STS, HSD17B12, COMT, AKR1C3, HSD17B8, CYP3A4, AKR1C1",1.30364361126667,0.401209493236885,FALSE +"H3255","Input","KEGG_SULFUR_METABOLISM",0.53852,1.62,0.0728,707,0.365,"SULT2B1, SUOX, PAPSS2",1.13786862068696,0.437707135543525,FALSE +"H3255","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.57395,-1.74,0.0302,9353,0.511,"C1S, TRIM21, C3, CD40",1.51999305704285,0.291579099865287,FALSE +"H3255","Input","KEGG_TASTE_TRANSDUCTION",0.26359,0.798,0.693,3980,0.909,"ITPR3, GNB3, GNAS, ADCY6, PRKACA, CACNA1A",0.159266765388193,0.0414361167780325,FALSE +"H3255","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.42654,1.33,0.133,1331,0.561,"PDSS2, HMGCS1, HMGCR, ACAT2",0.876148359032914,0.251037138743839,FALSE +"H3255","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.28957,-0.865,0.621,6712,0.811,"SMAD1, E2F4, SKP1, SMAD5, SMAD4, TGFBR1, AMH, MAPK3, MYC, SMAD2, CUL1, BMPR2, SP1, ID1, INHBA, PPP2R1B, SMAD9, TFDP1, BMPR1A, TGFB2",0.20690839982342,0.090979145788844,FALSE +"H3255","Input","KEGG_THYROID_CANCER",-0.34566,-1.04,0.379,8378,0.817,"PPARG, TFG, PAX8, MAP2K1, LEF1, TP53",0.421360790031928,0.0877779434675845,FALSE +"H3255","Input","KEGG_TIGHT_JUNCTION",0.24142,0.734,0.793,2180,0.928,"CLDN3, PATJ, CRB3, EPB41L3, PRKCH, AFDN, CTNNB1, CGN, OCLN, CLDN4, TJP3, MYH2, MPDZ, MAGI3, PARD6A, MYH7, MYH3, CTNNA1, TJP2, HRAS, PRKCI, PARD6G, AKT1",0.100726812682396,0.0324520237811379,FALSE +"H3255","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.25273,0.772,0.745,558,0.916,"LY96, MYD88, MAPK12, TLR2, IRF7, TOLLIP, MAPK13",0.127843727251707,0.0381045263321496,FALSE +"H3255","Input","KEGG_TRYPTOPHAN_METABOLISM",0.31548,0.972,0.474,1824,0.759,"ALDH2, GCDH, ALDH3A2, MAOA, OGDHL, ACAT2, OGDH, EHHADH",0.324221658325915,0.11975822410452,FALSE +"H3255","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.50204,-1.51,0.0744,9126,0.699,"PKM, MAPK8, PKLR, MAPK10, SOCS4, IRS2",1.12842706445412,0.155522824254319,FALSE +"H3255","Input","KEGG_TYROSINE_METABOLISM",-0.43489,-1.33,0.154,6964,0.736,"MIF, TAT, ADH5, ADH1C, METTL2B, GOT2, DCT, LCMT1, MAOB, ALDH3B1, ALDH1A3, HGD, LCMT2, ALDH3A1",0.812479279163537,0.133122185662501,FALSE +"H3255","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.28586,-0.865,0.598,8086,0.811,"PAK2, PAK3, FYN, CBLB, NCK1, SOS1, PIK3CB, LAT, PPP3CC, LCK, NCK2, MAP2K7, BCL10, MAP2K1, RAF1, NFATC1, CARD11, MALT1, PRKCQ, NFAT5, CBL",0.223298816011589,0.090979145788844,FALSE +"H3255","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.27742,-0.831,0.639,7165,0.839,"SIAH1, UBE2K, NEDD4, UBE2M, UBE2B, RNF7, UBA3, MID1, CUL2, CUL1, COP1, HERC3, XIAP, UBE4B, UBE4A, KEAP1, CBLB, CUL4A, VHL, WWP1, UBE2F, CDC26, UBE2Q1, UBE2E2, UBA1, UBE2D2, CUL4B, CUL5, HUWE1, BIRC2, PML, HERC4, UBE2E1, UBA7, CBL, FBXO2",0.1944991418416,0.0762380391712997,FALSE +"H3255","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.27274,-0.825,0.661,5944,0.81,"PDHB, VARS2, PDHA1, LARS2",0.17979854051436,0.0915149811213502,FALSE +"H3255","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.5036,1.55,0.0818,1996,0.393,"ACAD8, OXCT1, ALDH2, ALDH6A1, HMGCS1, ACAA1, IVD, BCKDHA, ALDH3A2, HIBADH, BCKDHB, ACAT2, BCAT2, ACADSB, EHHADH, HIBCH, PCCA",1.08724669632868,0.405607449624573,FALSE +"H3255","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.28456,-0.863,0.604,8757,0.805,"PLCB4, MAP2K1, RAF1, ARAF, MYLK, CACNA1F, PRKCQ, CALD1, PLA2G6",0.218963061378868,0.0942041196321315,FALSE +"H3255","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.1831,-0.556,0.988,6922,1,"DYNLL2, DYNC1LI1, ADCY3, DYNC1H1, VAMP2, ADCY9, DCTN5, DYNC2LI1, DCTN2, STX4, RAB11A, DCTN4, DCTN1, CREB5",0.00524305541237188,0,FALSE +"H3255","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.23102,0.715,0.854,1254,0.933,"PTGS2, PLA2G4A, MAPK12, MAPK13, PLA2G12A, VEGFA, PPP3R1, BAD",0.068542129310995,0.0301183562535,FALSE +"H3255","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.22932,0.71,0.832,3387,0.927,"PDIA4, ERO1A, KDELR1, SLC12A2, ATP6V1F, TJP2, ATP6AP1, GNAS, TJP1, ATP6V1G1, ATP6V1B1, ATP6V1E1, ATP6V1B2, ATP6V0A1, ACTB",0.0798766737092761,0.0329202658555029,FALSE +"H3255","Input","KEGG_VIRAL_MYOCARDITIS",0.22327,0.672,0.902,499,0.941,"ICAM1, CCND1, CD55",0.0447934624580583,0.0264103765727431,FALSE +"H3255","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.3,-0.914,0.525,7165,0.873,"SIAH1, CSNK2A1, CSNK2A2, MYC, CHP1, PPP2R5A, NFATC3, SMAD2, PLCB2, RAC3, CUL1, CACYBP, VANGL1, PPP2R5D, AXIN2, FZD2, PPP3CC, PORCN, RAC2, PLCB4, NLK, PPP2R1B, MMP7, NFATC1, CSNK1E, MAPK8, LEF1, MAPK10, SOX17, FZD7, WNT10A, FOSL1, NFAT5, WNT7A, TP53",0.279840696594043,0.0589857562944303,FALSE +"H358","Input","KEGG_ABC_TRANSPORTERS",-0.6212,-1.92,0.0154,7484,0.208,"ABCB4, ABCB7, ABCB6, ABCC5, ABCA1, ABCD1, ABCC3, ABCC6, ABCB1, ABCA3, ABCB10, ABCB8, ABCC2, ABCB11",1.81247927916354,0.681936665037238,TRUE +"H358","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.22332,0.69,0.884,1293,0.894,"PIK3R3, PIK3CD, RPS6KB2, RUNX1, CCND1, KRAS, NRAS, RPS6KB1, PIK3CA",0.0535477349869269,0.0486624812040823,FALSE +"H358","Input","KEGG_ADHERENS_JUNCTION",0.44542,1.36,0.13,1897,0.636,"RAC2, CDH1, CTNNA1, CTNND1, CTNNB1, CTNNA2, BAIAP2, LMO7, PTPRF, NECTIN4, ERBB2, SMAD3, RAC3, FARP2, MET, CSNK2A1, CSNK2A2, TJP1, PTPRJ, IGF1R, EP300, CREBBP, CSNK2B, ACTN4, NECTIN3, CDC42, YES1, PTPRB",0.886056647693163,0.196542884351586,FALSE +"H358","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.37773,1.2,0.207,940,0.507,"IRS1, SLC2A1, RXRA, MAPK10, MAPK9, RXRG, ADIPOR1, RXRB",0.684029654543082,0.294992040666664,FALSE +"H358","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.64866,-1.96,0.00949,8106,0.236,"ASNS, GPT, AGXT, ALDH5A1, GLS, GLS2, CPS1, GOT1, ALDH4A1, ASS1, ABAT, NIT2",2.02273378757271,0.627087997029893,TRUE +"H358","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.43781,1.33,0.143,409,0.625,"IRS1, SLC9A3R2, PIK3R3, SCNN1B, ATP1B1, PIK3CD",0.844663962534938,0.204119982655925,FALSE +"H358","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.6165,1.86,0.0278,974,0.551,"PLA2G4A, PLA2G12A",1.55595520408192,0.258848401148215,FALSE +"H358","Input","KEGG_ALZHEIMERS_DISEASE",-0.30126,-0.918,0.51,6143,0.688,"MAPK3, ATP5PO, NDUFS7, NDUFB6, ATP5PF, NDUFV1, COX6A1, NDUFS2, NDUFB10, ERN1, LRP1, ATP5F1E, NDUFV3, NDUFA8, NDUFS4, ATP5PB, GRIN1, NDUFA10, ATP5F1D, GNAQ, COX7A2L, GSK3B, NDUFA7, NDUFB2, COX6B1, MAPK1, ATP5F1B, CASP9, NDUFS6, NDUFV2, BID, ATP5PD, NDUFS3, ITPR3, APOE, ATP5F1C, NDUFS8, UQCRB, CYCS, ATP5F1A, GAPDH, APAF1, NDUFA5, UQCRC1, CDK5, PPP3CC, ATP5MC2, UQCRFS1, IDE, ITPR1, UQCRC2, ITPR2, SNCA, MAPT",0.292429823902064,0.162411561764489,FALSE +"H358","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.3828,-1.18,0.26,5801,0.406,"FARSA, NARS2, VARS2, FARSB, AARS2, TARS2, DARS2, CARS2, EARS2, RARS2",0.585026652029182,0.391473966422806,FALSE +"H358","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.45595,-1.37,0.112,6602,0.32,"UGP2, NAGK, GMPPA, GCK, MPI, GNE, GFPT1, HEXA, CYB5R3, NANS, PMM1, GNPDA1, GPI, UAP1, CYB5R1, RENBP, GALK1, CMAS, UXS1, PGM3, HEXB",0.950781977329818,0.494850021680094,FALSE +"H358","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.43894,-1.37,0.122,7699,0.32,"CYCS, APAF1, CASP1, CAT, MAPK12, MAPK11, BAX, CCS, PPP3CC, SOD1, NEFL, NEFM, TP53, PRPH, PRPH2, NEFH",0.913640169325252,0.494850021680094,FALSE +"H358","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.19338,0.598,0.972,2816,0.975,"PSME1, PSME2, B2M, HSPA2, PSME3, NFYC, NFYB, CREB1, HSPA1A, HSP90AB1, TAPBP, HSP90AA1, TAP1",0.0123337350737254,0.0109953843014632,FALSE +"H358","Input","KEGG_APOPTOSIS",0.24267,0.744,0.795,1584,0.835,"PIK3R3, TNFRSF10A, PIK3CD, CAPN2, PPP3CA, CASP6, PPP3R2, ENDOD1, PPP3R1, ENDOG, PIK3CA, FAS, CHP1, CAPN1, BAD",0.0996328713435297,0.0783135245163979,FALSE +"H358","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.38862,-1.18,0.242,7465,0.406,"GPX4, TBXAS1, GGT7, GGT1, GPX2, CBR3, CBR1, GPX6, GPX7, AKR1C3, ALOX5",0.616184634019569,0.391473966422806,FALSE +"H358","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.43376,-1.31,0.136,8508,0.327,"AGMAT, GLS, GLS2, CPS1, CKMT2, GOT1, SAT1, ALDH4A1, MAOB, ASS1, ALDH2, ARG2, CKMT1A",0.866461091629782,0.485452247339714,FALSE +"H358","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.30731,0.961,0.462,1649,0.706,"ITGB6, ITGB4, ITGA3, CTNNA1, LMNA, CTNNB1, CTNNA2, DSC2, DAG1, ITGB5, ITGA6, ATP2A2, DMD, DSG2, ITGA2, ACTN4",0.335358024443874,0.151195298948196,FALSE +"H358","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.37767,-1.16,0.257,7819,0.427,"ALDH7A1, ALDH2",0.590066876668705,0.369572124974976,FALSE +"H358","Input","KEGG_AXON_GUIDANCE",0.41139,1.25,0.202,1123,0.475,"RAC2, EPHA2, SEMA7A, EPHB2, SEMA3A, EPHA6, SEMA4B, EPHA1, RASA1, EPHB3, PPP3CA, EPHA5, EPHA4, SEMA4C, RAC3, NRP1, NGEF, PPP3R2, MET, KRAS, NRAS, EFNB2, PPP3R1",0.694648630553376,0.323306390375133,FALSE +"H358","Input","KEGG_BASAL_CELL_CARCINOMA",-0.49233,-1.5,0.0758,6906,0.267,"GSK3B, FZD7, FZD1, DVL3, DVL2, STK36, TCF7L2, LEF1, WNT16, TP53, WNT11",1.12033079436795,0.573488738635425,FALSE +"H358","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.32691,0.958,0.433,3472,0.698,"GTF2E2, TAF9B, GTF2B, TAF6L, TAF1, GTF2E1, GTF2IRD1, GTF2I, TAF5L, TAF5, GTF2F1, TAF6, TAF4, TAF2, GTF2A1",0.363512103646635,0.156144577376839,FALSE +"H358","Input","KEGG_BASE_EXCISION_REPAIR",0.59343,1.81,0.022,2035,0.405,"TDG, PCNA, POLD3, PARP2, NEIL2, UNG, FEN1, POLD1, LIG1, POLE3, MUTYH, APEX1, POLD2, APEX2, POLE2, POLB",1.65757731917779,0.392544976785331,FALSE +"H358","Input","KEGG_BETA_ALANINE_METABOLISM",-0.58564,-1.8,0.0235,6587,0.175,"SRM, ECHS1, ALDH1B1, ACADM, DPYD, MLYCD, ALDH7A1, EHHADH, ALDH2, ABAT",1.62893213772826,0.756961951313706,TRUE +"H358","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29329,0.901,0.553,1225,0.748,"HACD1, ELOVL5, ELOVL6, FADS1",0.257274868695302,0.126098402135539,FALSE +"H358","Input","KEGG_BLADDER_CANCER",0.36401,1.12,0.302,1089,0.504,"CDH1, THBS1, RB1, CCND1, ERBB2, KRAS, NRAS",0.519993057042849,0.297569463554475,FALSE +"H358","Input","KEGG_BUTANOATE_METABOLISM",-0.51511,-1.56,0.0596,7819,0.232,"ALDH7A1, ACADS, HMGCS1, AKR1B10, ACAT2, ALDH5A1, EHHADH, HMGCS2, ALDH2, ABAT",1.22475374025976,0.6345120151091,FALSE +"H358","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.31463,0.977,0.426,1362,0.687,"RAC2, PIK3R3, LYN, PIK3CD, PPP3CA, RAC3, PPP3R2, KRAS, NRAS, PPP3R1, PIK3CA, CHP1",0.370590400897281,0.16304326294045,FALSE +"H358","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2962,0.92,0.483,1857,0.764,"TNNC1, TNNC2, LTB4R2, PPP3CA, ERBB2, PLCB1, PTK2B, MYLK, PPP3R2, HRH1, CAMK2D, CACNA1A, PPP3R1, CAMK2G, CHP1, ERBB3, PRKCG, ATP2A2, ERBB4, PHKB, PPP3CB, ATP2B1, PHKA1",0.316052869248488,0.11690664142431,FALSE +"H358","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.29258,0.901,0.512,1505,0.748,"TNNC1, ATP1B1, SLC9A6, CYC1, SLC9A1, MYL3, UQCR10, ATP2A2",0.290730039024169,0.126098402135539,FALSE +"H358","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.46036,1.43,0.106,602,0.67,"CLDN7, CDH15, CDH3, ITGB2, CLDN4, SDC4, SDC1, CDH1, CD274, F11R, CNTN1, CLDN3, PTPRF, CD276, SDC2",0.97469413473523,0.173925197299174,FALSE +"H358","Input","KEGG_CELL_CYCLE",0.4905,1.46,0.107,1942,0.661,"FZR1, CDC20, CCNA2, MCM4, MCM7, ORC6, CHEK1, MCM5, MCM6, MCM3, BUB1, PCNA, CCNB1, RB1, PLK1, CCND1, CCNB2, SMAD3, MAD2L1, MCM2, SKP2, RBL1, BUB1B, TGFB2, CDC45, CDK1, CDK2, YWHAZ, CDC7, EP300, STAG2, CREBBP, RAD21, SMC3, SFN, CDC6, ESPL1, TTK, TFDP1, SMC1A, BUB3, ORC4, RBX1, PRKDC, YWHAQ, SMC1B",0.97061622231479,0.17979854051436,FALSE +"H358","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.26252,0.804,0.704,1326,0.796,"RAC2, PIK3R3, HCK, LYN, PIK3CD, GNG10, GRK2, PLCB1, PTK2B, GNG5, KRAS, NRAS, PRKCD, BCAR1, PIK3CA, PRKCZ",0.152427340857888,0.0990869322623309,FALSE +"H358","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.22527,-0.688,0.883,8017,0.94,"PIK3R1, CRKL, TGFB1, TGFB3, MAP2K2, CDKN2A, PIK3CB, CDKN1B, CRK, SOS1, TP53",0.0540392964224314,0.0268721464003014,FALSE +"H358","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.40871,-1.24,0.196,7527,0.351,"OGDH, PC, IDH1, OGDHL, ACO2, IDH2, PCK2",0.707743928643524,0.454692883534176,FALSE +"H358","Input","KEGG_COLORECTAL_CANCER",0.36981,1.15,0.244,1702,0.493,"RAC2, PIK3R3, CTNNB1, PIK3CD, MAPK10, MAPK9, CCND1, MSH6, SMAD3, MSH2, RAC3, TGFB2, KRAS, PIK3CA, MLH1, BAD, MSH3",0.612610173661271,0.30715308072277,FALSE +"H358","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.45796,-1.4,0.105,7947,0.343,"CFD, C3, FGB, PROS1, SERPIND1, SERPINE1, THBD, C5, F5, SERPINA1, C4A, SERPINF2, C9, SERPING1, A2M, PLG",0.978810700930062,0.464705879957229,FALSE +"H358","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.19193,-0.59,0.978,6360,0.978,"MAT2B, MTR, SRM, MTAP, SDS, APIP, MPST, ADI1, GOT1, CDO1",0.00966114521239857,0.00966114521239857,FALSE +"H358","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.35815,-1.09,0.335,7654,0.49,"IFNGR1, KIT, LEPR, IL17RA, CSF2RA, TGFB1, OSM, TGFB3, CD70, IL25, HGF, NGFR, IFNAR2, INHBE, IL6",0.474955192963155,0.309803919971486,FALSE +"H358","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.32932,-0.996,0.417,9147,0.582,"ZBP1, PYCARD, IL6",0.379863945026242,0.235077015350112,FALSE +"H358","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.31951,-0.976,0.46,8449,0.608,"SGCB, TGFB3, ITGB8, TPM2, ITGB3, ACTG1, SGCD, ITGA5, ITGA7, DES, ITGA4",0.337242168318426,0.216096420727265,FALSE +"H358","Input","KEGG_DNA_REPLICATION",0.71474,2.24,0.00218,1339,0.264,"MCM4, MCM7, POLA1, PRIM1, MCM5, MCM6, MCM3, PRIM2, PCNA, POLD3, RFC3, FEN1, POLD1, LIG1, MCM2, RFC4, POLA2, RFC5, POLE3, RFC2, RNASEH2A, DNA2, RNASEH2B, POLD2",2.6615435063954,0.578396073130169,FALSE +"H358","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.41391,1.3,0.152,1088,0.519,"NOTCH3, ETS1, KRAS",0.818156412055227,0.284832642151542,FALSE +"H358","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.44433,-1.37,0.124,8249,0.32,"GSTO1, CYP3A5, MGST3, GSTK1, MAOB, GSTM3, GSTM1, GSTM2, GSTM4",0.906578314837765,0.494850021680094,FALSE +"H358","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.29305,-0.898,0.558,8083,0.706,"GUSB, CYP3A5, CES1, CES2, UMPS, TPMT, NAT2",0.253365801062421,0.151195298948196,FALSE +"H358","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.37486,1.17,0.248,273,0.513,"ITGB6, LAMC2, TNC, ITGB4, SDC4, SDC1, ITGA3, LAMB3, LAMA5, AGRN, THBS1",0.605548319173784,0.289882634888184,FALSE +"H358","Input","KEGG_ENDOCYTOSIS",-0.2565,-0.792,0.719,6243,0.834,"AP2M1, SH3GL1, RNF41, IQSEC1, ACAP3, CHMP4A, CHMP4B, CLTB, RAB4A, PDCD6IP, EPN1, RAB5B, RBSN, SRC, AP2S1, PIP4K2B, RAB11FIP5, CBLB, EHD3, VPS36, STAM2, VTA1, PARD6G, VPS37C, HGS, PARD3, ARRB1, ASAP3, VPS4B, EPS15, PIP5K1C, CHMP3, PARD6B, DAB2, ARFGAP2, TRAF6, KIT, EEA1, PIKFYVE, ACAP2, VPS25, FGFR3, PRKCI, FGFR4, SNF8, ARFGAP1, ARFGAP3, CHMP5, DNM1L, ARRB2, ASAP2, DNM2, PLD1, GIT2, AP2A2, RABEP1, VPS37A, STAM, SH3GL2",0.143271109617117,0.0788339493622613,FALSE +"H358","Input","KEGG_ENDOMETRIAL_CANCER",0.34581,1.04,0.36,1584,0.617,"CDH1, CTNNA1, PIK3R3, CTNNB1, CTNNA2, PIK3CD, CCND1, ERBB2, PTEN, KRAS, NRAS, PIK3CA, MLH1, BAD",0.443697499232713,0.209714835966758,FALSE +"H358","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.23559,0.746,0.793,981,0.843,"MAPK13, F11R, LYN, MAPK10, MAPK9, MET, TJP1",0.100726812682396,0.0741724253752577,FALSE +"H358","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.38844,1.19,0.227,1584,0.495,"EREG, AREG, PIK3R3, PIK3CD, MAPK10, RPS6KB2, MAPK9, ERBB2, CAMK2D, KRAS, NRAS, RPS6KB1, MAP2K4, CAMK2G, PIK3CA, ERBB3, PRKCG, ERBB4, BAD",0.643974142806877,0.305394801066431,FALSE +"H358","Input","KEGG_ETHER_LIPID_METABOLISM",0.48928,1.49,0.0794,974,0.728,"LPCAT2, LPCAT4, PLPP2, LPCAT1, PLA2G4A, PLA2G12A",1.1001794975729,0.137868620686963,FALSE +"H358","Input","KEGG_FATTY_ACID_METABOLISM",-0.40144,-1.24,0.206,7739,0.351,"ECI2, ALDH7A1, ACADS, ACAT2, ACSL5, EHHADH, GCDH, ALDH2, ACADSB, ACAA2",0.686132779630847,0.454692883534176,FALSE +"H358","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.44116,1.39,0.102,1293,0.707,"MAPK13, RAC2, PIK3R3, LYN, PIK3CD, MAPK10, MAPK9, PLA2G4A, RAC3, PLA2G12A, KRAS, NRAS, PRKCD, MAP2K4, PIK3CA",0.991399828238082,0.150580586203101,FALSE +"H358","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.27061,0.83,0.637,685,0.794,"RAC2, PIK3R3, HCK, LYN, PLPP2, PIK3CD, RPS6KB2, PLA2G4A, MARCKSL1, SCIN",0.19586056766465,0.100179497572904,FALSE +"H358","Input","KEGG_FOCAL_ADHESION",0.27438,0.851,0.612,663,0.763,"RAC2, ITGB6, LAMC2, TNC, ITGB4, CAV1, ITGA3, CAV2, LAMB3, LAMA5, THBS1, PIK3R3, CTNNB1, PIK3CD, MAPK10, MAPK9, CAPN2, CCND1, ERBB2, PTEN",0.213248577854439,0.11747546204512,FALSE +"H358","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.56123,-1.71,0.0408,7518,0.186,"ALPG, QDPR, SPR, GGH",1.38933983691012,0.730487055782084,TRUE +"H358","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.26697,-0.823,0.661,6206,0.795,"PMM2, PFKP, TPI1, GMPPA, PFKM, MPI, PMM1, PFKL, MTMR6, AKR1B10, PHPT1, AKR1B1",0.17979854051436,0.0996328713435297,FALSE +"H358","Input","KEGG_GALACTOSE_METABOLISM",-0.27798,-0.88,0.559,5799,0.731,"GALT, GLA, GANC, PFKP, UGP2, GLB1, GCK, PFKM, PFKL, GALK1, AKR1B1",0.252588192113577,0.13608262304214,FALSE +"H358","Input","KEGG_GAP_JUNCTION",-0.29563,-0.945,0.516,6333,0.646,"PRKACB, GUCY1B1, GNA11, TUBA1C, TUBA1B, TUBB1, GNAI1, RAF1, TUBB, TUBA3C, SRC, GNAQ, TUBB2A, MAPK7, MAPK1, ITPR3, GRM5, TUBB6, GUCY1A1, TUBB2B, MAP2K2, GJA1, ITPR1, TUBB4A, ITPR2, SOS1",0.287350298372789,0.189767482004916,FALSE +"H358","Input","KEGG_GLIOMA",0.28779,0.882,0.544,1461,0.737,"PIK3R3, PIK3CD, RB1, CCND1, PTEN, CAMK2D, KRAS, NRAS, IGF1R, CAMK2G, PIK3CA, PRKCG",0.26440110030182,0.132532512140949,FALSE +"H358","Input","KEGG_GLUTATHIONE_METABOLISM",-0.53235,-1.69,0.0272,7465,0.191,"GPX4, GGT7, GSTP1, GSTA4, GGCT, IDH1, GGT1, GPX2, GSTO1, RRM2B, MGST3, ANPEP, IDH2, GPX6, GPX7, GSTK1, TXNDC12, GSTM3, GSTM1, GSTM2, GSTM4",1.5654310959658,0.718966632752272,TRUE +"H358","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.33778,-1.04,0.36,8822,0.533,"PLPP1, GK, AKR1B1, AKR1A1, ALDH2, AGPAT3",0.443697499232713,0.273272790973428,FALSE +"H358","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.32143,0.982,0.413,554,0.691,"LPCAT2, LPCAT4, MBOAT2, PLPP2, LPCAT1, CHKB, MBOAT1, PLA2G4A, GPAT3",0.384049948343599,0.160521952625802,FALSE +"H358","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.45088,-1.39,0.114,8322,0.334,"AGXT, PSPH, GCAT, SARDH, PSAT1, MAOB, GLDC",0.943095148663527,0.476253533188435,FALSE +"H358","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.23074,0.724,0.828,1568,0.855,"ALDH1A3, ADH4, ADH7, PKM, PGM2, PKLR, ENO1, ENO3, ALDH3A2, ALDH3B1",0.0819696632151199,0.0680338852718274,FALSE +"H358","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.56934,-1.74,0.0286,7600,0.184,"XYLT2, CHST13, CSGALNACT2, CHST12, B4GALT7, XYLT1, CHST3, CHST11",1.54363396687096,0.735182176990464,TRUE +"H358","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.35211,-1.09,0.33,7600,0.49,"XYLT2, NDST1, EXTL2, B4GALT7, XYLT1",0.481486060122112,0.309803919971486,FALSE +"H358","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.43658,-1.32,0.153,8711,0.331,"B4GALT4, ST3GAL1",0.815308569182401,0.480172006224281,FALSE +"H358","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.36731,-1.15,0.263,8073,0.433,"HGSNAT, GUSB, IDUA, GNS, HEXB, ARSB",0.580044251510242,0.363512103646635,FALSE +"H358","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.68557,-2.09,0.00202,8603,0.151,"NAGA, HEXB, ST3GAL1",2.69464863055338,0.821023052706831,TRUE +"H358","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.47613,-1.46,0.102,8711,0.288,"B4GALT4, FUT4, ST3GAL6",0.991399828238082,0.540607512240769,FALSE +"H358","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.37327,1.15,0.248,1236,0.493,"PIGG, PIGW, PIGK, PIGS, PIGT",0.605548319173784,0.30715308072277,FALSE +"H358","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.43064,-1.34,0.123,8167,0.331,"GRHPR, ACO2, PGP",0.910094888560602,0.480172006224281,FALSE +"H358","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.28301,0.884,0.536,1216,0.745,"MAPK13, MAPK10, MAPK9, PLA2G4A, PLCB1, PTK2B, PLA2G12A, CAMK2D, KRAS, NRAS, PRKCD, MAP2K4, CAMK2G",0.27083521030723,0.127843727251707,FALSE +"H358","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.33321,-1.03,0.395,8928,0.533,"WNT16, WNT11",0.40340290437354,0.273272790973428,FALSE +"H358","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.41356,-1.26,0.176,7735,0.341,"KIT, ITGA1, CSF2RA, ANPEP, ITGB3, CD7, ITGA5, ITGA4, IL6",0.75448733218585,0.467245621007502,FALSE +"H358","Input","KEGG_HISTIDINE_METABOLISM",-0.34815,-1.07,0.345,7312,0.515,"TRMT11, AOC1, ALDH7A1, HNMT, LCMT1, MAOB, DDC, ALDH2",0.462180904926726,0.288192770958809,FALSE +"H358","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.41437,1.26,0.176,2231,0.49,"POLD3, RAD54B, POLD1, RAD51C, EME1, RAD54L, POLD2, RPA3, BLM, RPA2, TOP3A, RPA1",0.75448733218585,0.309803919971486,FALSE +"H358","Input","KEGG_HUNTINGTONS_DISEASE",-0.33169,-1.03,0.386,6162,0.533,"ATP5PO, NDUFS7, NDUFB6, TFAM, ATP5PF, NDUFV1, AP2M1, COX6A1, NDUFS2, CLTB, NDUFB10, CREB5, ATP5F1E, NDUFV3, DNAL1, NDUFA8, NDUFS4, ATP5PB, GRIN1, NDUFA10, VDAC2, ATP5F1D, AP2S1, CREB3L2, GNAQ, COX7A2L, NDUFA7, NDUFB2, COX6B1, VDAC1, ATP5F1B, CASP9, POLR2I, DCTN4, NDUFS6, NDUFV2, ATP5PD, NDUFS3, IFT57, DNAH2, GRM5, TGM2, ATP5F1C, NDUFS8, UQCRB, CYCS, ATP5F1A, APAF1, NDUFA5, HIP1, UQCRC1, DCTN1, BAX, AP2A2, ATP5MC2, UQCRFS1, SOD1, DCTN2, ITPR1, UQCRC2, SOD2, TP53",0.413412695328245,0.273272790973428,FALSE +"H358","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.34436,-1.06,0.355,7794,0.523,"PRKAB2, ITGA1, CACNA2D2, ACE, TGFB1, SGCB, TGFB3, ITGB8, TPM2, ITGB3, ACTG1, SGCD, ITGA5, ITGA7, DES, ITGA4, IL6",0.449771646944906,0.281498311132726,FALSE +"H358","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.27896,-0.864,0.579,6782,0.744,"PIP4K2A, PIP4K2B, PIK3C2A, SYNJ1, PIK3C2B, OCRL, PIP5K1C, PLCG1, PIK3C3, INPP5K, PIKFYVE, PLCG2, ITPKA, IMPA1, MINPP1, ITPK1, PIK3CB, ITPKB",0.237321436272564,0.128427064454121,FALSE +"H358","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.19998,-0.623,0.949,6207,0.965,"RPTOR, TSC2, PRKAA1, PRKAR2A, MAPK8, PRKACB, PRKAA2, FLOT2, AKT3, PRKAG2, RAF1, PRKAR1A, GCK, CBLB, GSK3B, PIK3R2, RAPGEF1, MAPK1, RHEB, SHC1, PRKAG1, PPP1R3D, TSC1, PRKAR1B, GYS1, INPP5D, PRKAR2B, PRKAB2, IRS2, INPP5K, PIK3R1, PRKCI, PPP1R3A, CRKL, INSR, MAP2K2, PIK3CB, PDE3B, CRK, SORBS1, PCK2, FOXO1, SOS1",0.0227337875727074,0.0154726866562074,FALSE +"H358","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.68318,-2.1,0.00723,8209,0.186,"ICOSLG, TGFB1, ITGA4, IL6",2.14086170270547,0.730487055782084,TRUE +"H358","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.27411,-0.851,0.616,7649,0.75,"TYK2, IFNGR1, LEPR, STAT5A, PIK3R1, CSF2RA, OSM, PIM1, STAT2, STAM, PIK3CB, PIAS2, SOS1, IFNAR2, IL6",0.210419287835575,0.1249387366083,FALSE +"H358","Input","KEGG_LEISHMANIA_INFECTION",0.37631,1.16,0.267,52,0.516,"MAPK13, ITGB2, PTGS2",0.573488738635425,0.287350298372789,FALSE +"H358","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.45698,1.46,0.107,409,0.661,"CLDN7, MAPK13, RAC2, ITGB2, CLDN4, F11R, CTNNA1, CTNND1, PIK3R3, CLDN3, CTNNB1, CTNNA2, PIK3CD",0.97061622231479,0.17979854051436,FALSE +"H358","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.57323,-1.77,0.0253,6689,0.186,"ECHS1, ALDH1B1, ALDH7A1, EHHADH, ALDH2",1.59687947882418,0.730487055782084,TRUE +"H358","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.40407,1.27,0.175,974,0.491,"PLA2G4A, PLA2G12A",0.756961951313706,0.308918507877032,FALSE +"H358","Input","KEGG_LONG_TERM_DEPRESSION",-0.22166,-0.675,0.89,8896,0.937,"ITPR1, ITPR2, PPP1R17",0.0506099933550872,0.0282604091122217,FALSE +"H358","Input","KEGG_LONG_TERM_POTENTIATION",0.2607,0.807,0.67,1461,0.802,"PPP3CA, PLCB1, PPP3R2, CAMK2D, RPS6KA1, KRAS, NRAS, PPP3R1, CAMK2G, EP300, CHP1, CREBBP, PRKCG",0.173925197299174,0.0958256317158365,FALSE +"H358","Input","KEGG_LYSINE_DEGRADATION",-0.34335,-1.05,0.343,7412,0.531,"PLOD1, AASS, OGDH, ALDH7A1, PLOD3, OGDHL, ACAT2, SETDB1, EHHADH, GCDH, ALDH2, TMLHE",0.464705879957229,0.274905478918531,FALSE +"H358","Input","KEGG_LYSOSOME",-0.42291,-1.28,0.163,6514,0.34,"AP3D1, AP3S1, LAMP2, ENTPD4, GLB1, NEU1, ASAH1, AP3B1, PSAP, AP3M2, LAMP1, CLN5, ARSA, HEXA, GBA, ATP6V0D2, ATP6V0A2, CTSH, CTSA, AP3M1, ACP5, CTSK, CTSO, LIPA, GGA1, TPP1, ATP6V1H, NAPSA, ATP6V0A1, SUMF1, GGA2, CTSZ, HGSNAT, GUSB, AP3S2, IDUA, ACP2, DNASE2, AP1M1, NAGPA, PLA2G15, NAGA, GNS, PPT2, GM2A, IGF2R, CLN3, SMPD1, MAN2B1, HEXB, CD63, ARSB, SLC17A5",0.787812395596042,0.468521082957745,FALSE +"H358","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.24673,-0.754,0.763,7883,0.895,"FLNC, MAP4K3, TAB1, MAPK8IP3, CACNA2D2, FGFR3, CRKL, MAP3K11, DUSP3, MAP3K7, FGFR4, MAPK12, TGFB1, RELB, ARRB2, MAPK11, TGFB3, MAP2K2, NFKB2, FGFR1, PPP3CC, TAOK3, CRK, DUSP9, RASA2, SOS1, TP53, FGF13, FGF2, STK4, MAPT",0.11747546204512,0.048176964684088,FALSE +"H358","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.6123,-1.89,0.0179,7830,0.186,"IAPP, HNF1B, PDX1, HNF1A, HNF4A, MNX1, PAX6, NEUROD1",1.74714696902011,0.730487055782084,TRUE +"H358","Input","KEGG_MELANOGENESIS",-0.24352,-0.748,0.801,6685,0.896,"RAF1, CREB3L2, GNAQ, GSK3B, FZD7, MAPK1, MITF, ASIP, FZD1, TYRP1, DVL3, DVL2, KIT, TCF7L2, MAP2K2, LEF1, DCT, WNT16, WNT11",0.0963674839157623,0.0476919903378748,FALSE +"H358","Input","KEGG_MELANOMA",-0.30676,-0.953,0.491,8517,0.641,"MAP2K2, CDKN2A, FGFR1, PIK3CB, HGF, TP53, FGF13, FGF2",0.308918507877032,0.193141970481183,FALSE +"H358","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.53266,-1.58,0.0641,8249,0.234,"GSTO1, CYP3A5, MGST3, GSTK1, AKR1C3, AKR1C1, GSTM3, GSTM1, GSTM2, GSTM4, AKR1C2",1.19314197048118,0.630784142589857,FALSE +"H358","Input","KEGG_MISMATCH_REPAIR",0.69746,2.18,0.0104,2231,0.182,"PCNA, POLD3, MSH6, RFC3, POLD1, LIG1, MSH2, RFC4, RFC5, RFC2, POLD2, MLH1, RFC1, MSH3, RPA3, RPA2, RPA1",1.98296666070122,0.739928612014925,TRUE +"H358","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.29271,0.896,0.525,1293,0.745,"CAB39, PIK3R3, PIK3CD, RPS6KB2, HIF1A, RPS6KA1, RPS6KB1, PIK3CA",0.279840696594043,0.127843727251707,FALSE +"H358","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.43174,1.32,0.136,1461,0.613,"RAC2, ITGB2, LCK, RAET1L, ULBP2, PIK3R3, TNFRSF10A, PIK3CD, PPP3CA, RAC3, PTK2B, PPP3R2, KRAS, NRAS, PPP3R1, PIK3CA, FAS, CHP1, PRKCG",0.866461091629782,0.212539525481585,FALSE +"H358","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.41402,-1.29,0.184,6579,0.336,"GRIN1, TSPO, PARD3, GRM5, LEPR, P2RX4, TACR1, PRSS3, PLG",0.735182176990464,0.473660722610156,FALSE +"H358","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.24965,0.758,0.778,1612,0.834,"MAPK13, IRS1, RPS6KA4, PIK3R3, PIK3CD, MAPK10, MAPK9, ARHGDIB, CAMK2D, RPS6KA1, KRAS, NRAS, PRKCD, CAMK2G, YWHAZ, KIDINS220, PIK3CA, BAD, FRS2, CSK, SORT1",0.109020403010311,0.0788339493622613,FALSE +"H358","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.53954,-1.68,0.0353,8626,0.189,"ENPP1, NNMT, BST1, NMNAT3, QPRT",1.45222529461218,0.723538195826756,TRUE +"H358","Input","KEGG_NITROGEN_METABOLISM",-0.63599,-1.95,0.0152,8024,0.209,"CA1, ASNS, CA8, GLS, GLS2, CPS1, CA12, CA2",1.81815641205523,0.679853713888946,TRUE +"H358","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.23521,-0.735,0.819,7691,0.898,"TRAF6, TAB1, CASP1, MAP3K7, MAPK12, MAPK11, PYCARD, IL6",0.0867160982395816,0.0467236633326956,FALSE +"H358","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.43034,1.33,0.131,851,0.625,"FEN1, XRCC5, XRCC6",0.882728704344236,0.204119982655925,FALSE +"H358","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.26132,0.802,0.686,1584,0.788,"PIK3R3, RXRA, PIK3CD, RB1, CCND1, ERBB2, RXRG, RXRB, KRAS, NRAS, PIK3CA, PRKCG, BAD",0.163675884293248,0.103473782510445,FALSE +"H358","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.45266,1.38,0.117,1722,0.68,"NOTCH3, JAG2, JAG1, NCOR2, RBPJ, CTBP1, EP300, CREBBP, KAT2A, DVL1",0.931814138253838,0.167491087293764,FALSE +"H358","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.53415,1.65,0.0445,2231,0.632,"PCNA, POLD3, RFC3, POLD1, LIG1, RFC4, RFC5, POLE3, RFC2, CUL4A, POLD2, RFC1, DDB2, RBX1, RPA3, POLE2, RPA2, CUL4B, RPA1",1.35163998901907,0.199282921717615,FALSE +"H358","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.2729,-0.851,0.607,7776,0.75,"ST6GAL1, MGAT4B, DPAGT1, MGAT3, MGAT1, MAN1A1, ALG11, MGAT5",0.216811308924742,0.1249387366083,FALSE +"H358","Input","KEGG_OLFACTORY_TRANSDUCTION",0.35112,1.07,0.351,1818,0.576,"CAMK2D, CAMK2G, CNGB1",0.454692883534176,0.239577516576788,FALSE +"H358","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.36155,-1.1,0.308,6496,0.49,"MTHFD2L, MTR, TYMS, GART, ALDH1L1, MTHFR",0.511449283499556,0.309803919971486,FALSE +"H358","Input","KEGG_OOCYTE_MEIOSIS",0.38869,1.19,0.249,1993,0.495,"CDC20, AR, STAG3, BUB1, CCNB1, PLK1, PPP3CA, CCNB2, MAD2L1, AURKA, PPP3R2, BTRC, CAMK2D, CDK1, RPS6KA1, IGF1R, CDK2, PPP2CB, PPP3R1, CAMK2G, YWHAZ, PPP2R5C, CHP1, PPP2R5E, SMC3, ESPL1, PPP3CB, SMC1A, RBX1, YWHAQ, SMC1B, SGO1",0.603800652904264,0.305394801066431,FALSE +"H358","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.41248,-1.29,0.162,6428,0.336,"MAN2C1, GLB1, NEU1, HEXA, GBA, MAN2B1, HEXB",0.790484985457369,0.473660722610156,FALSE +"H358","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.43471,-1.33,0.153,6162,0.327,"ATP5PO, NDUFS7, NDUFB6, ATP5PF, NDUFV1, COX6A1, NDUFS2, NDUFB10, ATP6V1C1, ATP5F1E, NDUFV3, NDUFA8, NDUFS4, ATP5PB, NDUFA10, ATP5F1D, COX7A2L, NDUFA7, NDUFB2, ATP6V1F, COX6B1, ATP5F1B, NDUFS6, ATP6V1D, ATP6V0D2, NDUFV2, ATP5PD, ATP6V0A2, NDUFS3, ATP5F1C, NDUFS8, UQCRB, ATP6V1C2, ATP5ME, ATP6V1A, ATP5F1A, ATP6V1H, ATP6V1B2, ATP6V1B1, NDUFA5, ATP6V0A1, ATP6V1E1, UQCRC1, COX15, ATP5MC2, UQCRFS1, COX11, UQCRC2, ATP6V1G1",0.815308569182401,0.485452247339714,FALSE +"H358","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.58837,1.84,0.0173,634,0.447,"GALNT13, GALNT7, GALNT3, GALNT10, GALNT6, GALNT15",1.7619538968712,0.349692476868064,FALSE +"H358","Input","KEGG_P53_SIGNALING_PATHWAY",0.39489,1.24,0.186,1324,0.46,"SERPINB5, THBS1, CHEK1, STEAP3, CCNB1, CCND1, CCNB2, EI24, RRM2, PTEN, CDK1, CDK2, GTSE1, FAS",0.730487055782084,0.337242168318426,FALSE +"H358","Input","KEGG_PANCREATIC_CANCER",0.36209,1.14,0.276,1088,0.484,"RAC2, PIK3R3, PIK3CD, MAPK10, RB1, MAPK9, RALB, CCND1, ERBB2, SMAD3, RAC3, TGFB2, KRAS",0.559090917934782,0.315154638355588,FALSE +"H358","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.6089,-1.9,0.0107,6783,0.2,"PANK3, DPYD, PPCS, PANK4, ENPP1, BCAT1",1.97061622231479,0.698970004336019,TRUE +"H358","Input","KEGG_PARKINSONS_DISEASE",-0.4253,-1.27,0.172,6104,0.337,"SLC18A1, ATP5PO, NDUFS7, NDUFB6, ATP5PF, NDUFV1, COX6A1, NDUFS2, NDUFB10, ATP5F1E, NDUFV3, NDUFA8, NDUFS4, ATP5PB, NDUFA10, VDAC2, ATP5F1D, COX7A2L, NDUFA7, NDUFB2, COX6B1, VDAC1, ATP5F1B, CASP9, NDUFS6, NDUFV2, ATP5PD, NDUFS3, HTRA2, ATP5F1C, NDUFS8, UQCRB, CYCS, ATP5F1A, APAF1, NDUFA5, UQCRC1, UBE2L3, UBA7, UBE2G1, ATP5MC2, UQCRFS1, UBE2J1, UQCRC2, SNCA, UCHL1",0.764471553092451,0.472370099128661,FALSE +"H358","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.21291,-0.656,0.929,6266,0.941,"ARPC5L, ARPC4, TUBA1C, ARHGEF2, TUBA1B, TUBB1, NCK1, ARPC2, TUBB, TUBA3C, ARPC1B, ARPC5, TUBB2A, CLDN1, WASL, ROCK1, TUBB6, HCLS1, FYN, NCK2, TUBB2B, TUBB4A, ACTG1",0.0319842860063582,0.0264103765727431,FALSE +"H358","Input","KEGG_PATHWAYS_IN_CANCER",0.29168,0.905,0.57,1132,0.767,"RAC2, LAMC2, PTGS2, SLC2A1, ITGA3, CDH1, LAMB3, AR, LAMA5, CTNNA1, MAX, PIK3R3, PIAS1, CTNNB1, CTNNA2, RXRA, PIK3CD, MAPK10, RB1, MAPK9, RUNX1, RALB, CCND1, MSH6, ETS1, ERBB2, RXRG, PTEN, SMAD3, MSH2, SKP2, RAC3, CTBP1, HIF1A, MECOM, MET, CKS1B, TGFB2, RXRB, KRAS, NRAS, IGF1R, ITGA6, CDK2, FZD6",0.244125144327509,0.115204636051019,FALSE +"H358","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.50067,-1.53,0.0751,7692,0.25,"RPE, CRYL1, GUSB, XYLB, AKR1B1",1.12436006299583,0.602059991327962,FALSE +"H358","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.34873,-1.04,0.374,6220,0.533,"PRPS1, PRPS1L1, TALDO1, PFKP, PFKM, PFKL, RPE, GPI, DERA, H6PD, PGLS",0.42712839779952,0.273272790973428,FALSE +"H358","Input","KEGG_PEROXISOME",-0.44496,-1.37,0.117,7272,0.32,"HSD17B4, DHRS4, DAO, PXMP4, PRDX1, MLYCD, ECI2, IDH1, PEX5, PECR, DECR2, CAT, CRAT, ABCD1, HACL1, AGXT, IDH2, ACSL5, EHHADH, GSTK1, SOD1, FAR2, SOD2, NUDT19, PHYH, ECH1",0.931814138253838,0.494850021680094,FALSE +"H358","Input","KEGG_PHENYLALANINE_METABOLISM",-0.35979,-1.12,0.292,8710,0.469,"GOT1, MAOB, DDC",0.534617148551582,0.328827157284917,FALSE +"H358","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.27855,-0.873,0.609,6782,0.736,"PIP4K2A, PIP4K2B, PIK3C2A, PIK3R2, SYNJ1, PIK3C2B, OCRL, PIP5K1C, ITPR3, PLCG1, INPP5D, PIK3C3, INPP5K, PIKFYVE, PLCG2, PIK3R1, ITPKA, IMPA1, ITPK1, PIK3CB, ITPKB, ITPR1, ITPR2",0.215382707367125,0.133122185662501,FALSE +"H358","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.42796,-1.31,0.151,7931,0.327,"CPOX, GUSB, EARS2, HMOX1, COX15, BLVRA, UROS, BLVRB, FTH1",0.821023052706831,0.485452247339714,FALSE +"H358","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.4506,-1.36,0.136,7615,0.324,"FABP5, APOA1, OLR1, SCD, ILK, SLC27A6, ACSL5, EHHADH, HMGCS2, SLC27A1, APOA2, SORBS1, PCK2, GK, FABP1, CYP27A1, FABP7, FABP3",0.866461091629782,0.489454989793388,FALSE +"H358","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.59486,-1.85,0.022,6247,0.183,"ACOX2, AMACR, HSD17B4, AKR1D1, CYP27A1",1.65757731917779,0.737548910269571,TRUE +"H358","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.41778,1.31,0.154,583,0.547,"LCK, UNG",0.812479279163537,0.262012673666569,FALSE +"H358","Input","KEGG_PRION_DISEASES",-0.57953,-1.82,0.0306,8236,0.189,"FYN, BAX, C5, MAP2K2, SOD1, C9, IL6",1.51427857351842,0.723538195826756,TRUE +"H358","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.45866,1.37,0.137,1098,0.656,"MAPK13, FZR1, CCNA2, PIK3R3, BUB1, PIK3CD, MAPK10, CCNB1, PLK1, MAPK9, CCNB2, MAD2L1, CDK1, RPS6KA1, KRAS, IGF1R, CDK2",0.863279432843593,0.18309616062434,FALSE +"H358","Input","KEGG_PROPANOATE_METABOLISM",-0.57885,-1.8,0.0194,6689,0.175,"ECHS1, ALDH1B1, PCCA, ACADM, MLYCD, ALDH7A1, ACAT2, ACSS1, ACSS2, ACSS3, PCCB, EHHADH, MCEE, ALDH2, ABAT",1.71219827006977,0.756961951313706,TRUE +"H358","Input","KEGG_PROSTATE_CANCER",0.26226,0.807,0.665,1404,0.802,"AR, PIK3R3, CTNNB1, PIK3CD, RB1, CCND1, ERBB2, PTEN, KRAS, NRAS, IGF1R, CDK2, PIK3CA, EP300, CREBBP",0.177178354696895,0.0958256317158365,FALSE +"H358","Input","KEGG_PROTEASOME",0.17383,0.543,0.993,1486,0.987,"PSME1, PSME2, PSMB8, PSME3",0.00305075150461883,0.00568284733036327,FALSE +"H358","Input","KEGG_PROTEIN_EXPORT",-0.17313,-0.529,0.99,8519,0.991,"SEC11C, IMMP1L",0.00436480540245009,0.00392634551472468,FALSE +"H358","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.54988,-1.67,0.0506,8513,0.188,"GLS, GLS2, ATP1B3, PCK2, AQP1, CA2",1.2958494831602,0.72584215073632,FALSE +"H358","Input","KEGG_PURINE_METABOLISM",0.26219,0.828,0.665,982,0.785,"PDE5A, NT5E, POLA1, PRIM1, PRIM2, PKM, POLD3, NME7, POLD1, RRM2, NME3, POLA2, POLE3, POLR3C, PDE4D, POLR3F, ENTPD6, POLR3B, DCK, POLR3G",0.177178354696895,0.105130343254747,FALSE +"H358","Input","KEGG_PYRIMIDINE_METABOLISM",0.39848,1.25,0.193,1339,0.475,"CDA, NT5E, POLA1, PRIM1, DUT, PRIM2, POLD3, NME7, POLD1, RRM2, UCK2, NME3, POLA2, POLE3, POLR3C, POLR3F, ENTPD6, POLR3B, DCK, POLR3G, TK1, TK2, PNP, UCK1, POLD2",0.714442690992226,0.323306390375133,FALSE +"H358","Input","KEGG_PYRUVATE_METABOLISM",-0.45103,-1.39,0.118,7460,0.334,"ACYP1, PC, ALDH7A1, GRHPR, ACAT2, ACSS1, ACSS2, PCK2, AKR1B1, ALDH2, HAGH",0.928117992693875,0.476253533188435,FALSE +"H358","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.21013,-0.659,0.928,7837,0.948,"ITGA1, GSN, PIKFYVE, PIK3R1, DOCK1, FGFR3, ENAH, CRKL, VCL, FGFR4, MYH10, ARHGEF6, FGD1, MAP2K2, FN1, FGFR1, ITGB8, PIK3CB, CRK, ITGB3, ACTG1, SOS1, IQGAP2, ITGA5, ITGA7, FGF13, FGF2, ITGA4",0.0324520237811379,0.0231916626619338,FALSE +"H358","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.57295,-1.76,0.0382,6267,0.181,"PRKAA1, PIK3R4, PRKAA2, ATG3, ATG4A, ULK1, PIK3C3, ATG12, ATG4B, GABARAPL1, ULK3",1.41793663708829,0.742321425130815,TRUE +"H358","Input","KEGG_RENAL_CELL_CARCINOMA",0.25478,0.766,0.748,1980,0.843,"SLC2A1, PIK3R3, PIK3CD, ETS1, HIF1A, MET, TGFB2, KRAS, NRAS, PIK3CA, EP300, CREBBP, ELOC, CDC42, RBX1, ELOB, JUN",0.126098402135539,0.0741724253752577,FALSE +"H358","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.53302,-1.64,0.0363,7507,0.202,"CTSA, ENPEP, ACE, AGT, ANPEP",1.44009337496389,0.694648630553376,TRUE +"H358","Input","KEGG_RETINOL_METABOLISM",-0.38819,-1.21,0.234,8270,0.381,"CYP3A5, RDH10, ALDH1A2, ALDH1A1",0.630784142589857,0.419075024324381,FALSE +"H358","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.43072,-1.33,0.129,7532,0.327,"ACP5, MTMR6, ACP2, ENPP1, PHPT1",0.889410289700751,0.485452247339714,FALSE +"H358","Input","KEGG_RIBOSOME",0.27159,0.859,0.619,3836,0.772,"RPS4Y1, RPL22, FAU, RPS23, RPS25, RPS3A, RPL23A, RPL8, RPS11, RPS8, RPS29, RPL7, RPL34, RPS5, RPL28, RPL7A, RPS15, RPS13, RPL10, RPL18, RPS27L, RPL26, RPS17, RPS9, RPL37A, RPL36A, RPL36AL, RPS2, RPS6, RPL36, RPL15, RPL21, RPS18, RPL17, RPL10A, RPL5, RPL27, RPL19, RPL18A, RPL11, RPL14, RPL32, RPL13A, RPS16, MRPL13, RPL13",0.208309350979882,0.112382699664264,FALSE +"H358","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.37634,1.15,0.251,952,0.493,"MAPK13, DDX3Y, ISG15, MAPK10, MAPK9, DDX58, TKFC",0.600326278518962,0.30715308072277,FALSE +"H358","Input","KEGG_RNA_DEGRADATION",0.31524,0.984,0.438,2938,0.701,"XRN2, PAPOLA, EXOSC5, EXOSC6, DCPS, PAPOLG, EXOSC9, EXOSC8, EXOSC7, ENO1, DIS3, ENO3, EXOSC3, EXOSC10, EXOSC2, CNOT6, CNOT6L, MTREX, DDX6, DCP1A, LSM6, LSM8, LSM1, EXOSC1, LSM2",0.3585258894959,0.154281982033341,FALSE +"H358","Input","KEGG_RNA_POLYMERASE",0.41045,1.28,0.174,3305,0.532,"POLR3C, POLR3F, POLR3B, POLR3G, POLR3A, POLR2K, POLR1B, POLR3H, POLR1A, POLR3D, POLR1E, POLR1C, POLR1D, POLR3K, POLR2B",0.7594507517174,0.274088367704952,FALSE +"H358","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.23458,-0.727,0.83,6033,0.901,"SEPHS2, AHCY, MAT2B, METTL2B, TRMT11, GGT7, GGT1, LCMT1, PAPSS2",0.0809219076239261,0.045275209020937,FALSE +"H358","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.41269,1.27,0.186,1098,0.491,"LAMC2, PTGS2, ITGA3, LAMB3, LAMA5, MAX, PIK3R3, PIAS1, RXRA, PIK3CD, RB1, CCND1, RXRG, PTEN, SKP2, CKS1B, RXRB, ITGA6, CDK2",0.730487055782084,0.308918507877032,FALSE +"H358","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.23245,-0.713,0.833,6730,0.913,"SNAP25, USE1, GOSR2, VAMP7, VAMP5, SNAP29, STX7, BET1, YKT6, STX2",0.0793549985932124,0.039529222465701,FALSE +"H358","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.24352,-0.738,0.781,6538,0.903,"SGPP1, GLB1, NEU1, ASAH1, ARSA, UGCG, GBA, KDSR, SMPD2, SMPD3, PLPP1, SMPD1",0.1073489661227,0.0443122496864942,FALSE +"H358","Input","KEGG_SPLICEOSOME",0.40037,1.24,0.191,3679,0.46,"DHX8, DHX15, ALYREF, DDX42, SNRPB2, DHX16, CTNNBL1, DDX5, SNRPA1, HSPA2, PRPF3, AQR, CDC5L, SF3B1, NCBP1, DHX38, DDX46, U2AF2, SRSF5, CRNKL1, PUF60, SF3B3, RBMX, SRSF8, DDX39B, CWC15, SNRPE, BCAS2, PRPF4, PHF5A, SART1, HSPA1A, PLRG1, SNRPD1, SNRPD2, XAB2, SNRNP200, LSM6, EIF4A3, PRPF19, THOC1, SF3B4, RBM25, LSM8, USP39, SF3B6, SRSF9, LSM2, SF3A3, TRA2A, HNRNPM, HNRNPA1, SNW1, PRPF40A, SNRPB, ISY1, SF3B5, PRPF38A, SNRPA, U2AF1, PRPF8, LSM3, SF3A1, PPIL1, SNRPD3, SRSF6, HNRNPK, HSPA6, SRSF2, PRPF31, THOC2, PRPF6, SNRNP70",0.718966632752272,0.337242168318426,FALSE +"H358","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.22692,-0.686,0.881,7549,0.933,"GYS1, GPI, GUSB, ENPP1, SI, UXS1",0.0550240915879521,0.0301183562535,FALSE +"H358","Input","KEGG_STEROID_BIOSYNTHESIS",-0.49274,-1.49,0.0857,7665,0.267,"CEL, LIPA, SOAT2, FDFT1, SQLE",1.0670191780768,0.573488738635425,FALSE +"H358","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.72859,-2.18,0.00743,8270,0.189,"CYP3A5, AKR1D1, CYP21A2, HSD3B1, AKR1C3, HSD17B2, AKR1C1, HSD11B2, AKR1C2",2.12901118623942,0.723538195826756,TRUE +"H358","Input","KEGG_SULFUR_METABOLISM",-0.7871,-2.43,0,7602,0.0599,"SULT1A3, CHST13, SUOX, PAPSS2, CHST12, CHST11, SULT1A1",Inf,1.22257317761069,TRUE +"H358","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.40922,-1.27,0.16,6645,0.337,"ELANE, CD40, TRIM21, C3, C5, C4A, C9",0.795880017344075,0.472370099128661,FALSE +"H358","Input","KEGG_TASTE_TRANSDUCTION",0.47947,1.5,0.0983,1100,0.794,"SCNN1B, CACNA1A",1.00744648216786,0.100179497572904,FALSE +"H358","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.50306,-1.56,0.0649,7194,0.232,"PDSS2, GGPS1, HMGCR, HMGCS1, ACAT2, HMGCS2, IDI1",1.18775530319963,0.6345120151091,FALSE +"H358","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.2907,0.886,0.572,1404,0.754,"SMURF1, THBS1, ID1, RPS6KB2, SMAD3, RBL1, ACVR1, TGFB2, PPP2CB, RPS6KB1, SMURF2, EP300, CREBBP",0.242603971206976,0.122628654130226,FALSE +"H358","Input","KEGG_THYROID_CANCER",0.37034,1.14,0.264,1089,0.484,"CDH1, CTNNB1, RXRA, CCND1, RXRG, RXRB, KRAS, NRAS",0.578396073130169,0.315154638355588,FALSE +"H358","Input","KEGG_TIGHT_JUNCTION",0.4082,1.27,0.172,1464,0.491,"CLDN7, PRKCH, CLDN4, F11R, CTNNA1, CLDN3, CTNNB1, CTNNA2, LLGL2, PATJ, CRB3, CASK, PTEN, MYH9, MYH11, RAB13, CSNK2A1, CSNK2A2, TJP1, MAGI3, CGN, KRAS, NRAS, EPB41L1, PPP2CB, TJP2, PRKCD, OCLN, PRKCZ, MYL12A, PRKCG, CSNK2B",0.764471553092451,0.308918507877032,FALSE +"H358","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.26182,-0.801,0.707,6324,0.827,"MAPK8, RELA, IKBKG, AKT3, IRF3, TRAF3, CHUK, TBK1, CD40, PIK3R2, RIPK1, MAPK1, SPP1, IRAK4, CTSK, TRAF6, LBP, TAB1, PIK3R1, MAP3K7, MAPK12, MAPK11, TOLLIP, MAP2K2, PIK3CB, IFNAR2, IL6",0.150580586203101,0.0824944904474534,FALSE +"H358","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.55285,-1.71,0.0405,7375,0.186,"AOC1, KYNU, OGDH, ALDH7A1, CAT, OGDHL, ACAT2, EHHADH, MAOB, DDC, GCDH, ALDH2",1.39254497678533,0.730487055782084,TRUE +"H358","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.48852,1.52,0.0811,1342,0.848,"IRS1, PIK3R3, PIK3CD, MAPK10, PKM, MAPK9, ABCC8, CACNA1A, PRKCD, PIK3CA, PRKCZ, PKLR",1.09097914578884,0.0716041477432862,FALSE +"H358","Input","KEGG_TYROSINE_METABOLISM",0.32926,1.02,0.354,410,0.642,"ALDH1A3, ADH4, ADH7, MAOA",0.450996737974212,0.192464971931147,FALSE +"H358","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.27725,0.857,0.624,1362,0.764,"MAPK13, LCK, PIK3R3, PIK3CD, MAPK9, PPP3CA, PPP3R2, KRAS, NRAS, PPP3R1, TEC, PIK3CA, CHP1",0.204815410317576,0.11690664142431,FALSE +"H358","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29576,0.909,0.523,2737,0.772,"FZR1, CDC20, UBE2C, SMURF1, PIAS1, UBE2E2, FANCL, UBE2S, UBE3A, WWP2, SKP2, CUL4A, UBE2W, BTRC, CUL3, UBR5, UBE2O, SMURF2, ITCH, UBA3, DDB2, ELOC, PIAS3, BRCA1, RBX1, ELOB, UBE4A, CUL4B, PPIL2, MAP3K1, RNF7, UBE2A, CUL5, MID1, UBA6, COP1, PML, DDB1, UBE2D2, UBE2K, UBE4B, PRPF19",0.281498311132726,0.112382699664264,FALSE +"H358","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.61649,-1.86,0.0212,8770,0.192,"BCAT1",1.67366413907125,0.71669877129645,TRUE +"H358","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.51404,-1.58,0.0585,7819,0.234,"ALDH7A1, ACADS, HMGCS1, BCKDHB, ACAT2, PCCB, EHHADH, MCEE, HMGCS2, BCAT1, ALDH2, ACADSB, ABAT, ACAA2",1.23284413391782,0.630784142589857,FALSE +"H358","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.24199,0.764,0.744,1186,0.835,"PRKCH, PPP1R14A, PLA2G4A, PLCB1, MYL6, MYH11, MYLK, PLA2G12A, PRKCD",0.128427064454121,0.0783135245163979,FALSE +"H358","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.29197,-0.901,0.524,5911,0.71,"DYNC1I2, DYNC2LI1, RAB5C, DYNC2H1, PRKACB, CREB5, RAB5B, CREB3L2, DYNC1LI1, DCTN4, DCTN6, DCTN5, DYNLL1, DCTN1, DCTN2",0.280668713016273,0.148741651280925,FALSE +"H358","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.43288,1.31,0.159,1829,0.547,"MAPK13, RAC2, PTGS2, PIK3R3, PIK3CD, PLA2G4A, PPP3CA, RAC3, PPP3R2, PLA2G12A, KRAS, NRAS, PPP3R1, PIK3CA, CHP1, PRKCG, BAD, PPP3CB, CDC42",0.798602875679548,0.262012673666569,FALSE +"H358","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.43673,-1.34,0.142,7218,0.331,"ATP6V1D, ATP6V0D2, ATP6V0A2, PDIA4, ATP6V1C2, PLCG1, ATP6V1A, ATP6V1H, ATP6V1B2, ATP6V1B1, ATP6V0A1, ATP6V1E1, PLCG2, KDELR1, ACTG1, ATP6V1G1",0.847711655616944,0.480172006224281,FALSE +"H358","Input","KEGG_VIRAL_MYOCARDITIS",0.41889,1.3,0.158,984,0.519,"RAC2, ITGB2, CAV1, CCND1, MYH9, RAC3, MYH11, DAG1, CD55",0.801342913045577,0.284832642151542,FALSE +"H358","Input","KEGG_WNT_SIGNALING_PATHWAY",0.43014,1.31,0.174,1464,0.547,"RAC2, NKD2, CTNNB1, CHD8, FOSL1, MAPK10, VANGL1, MAPK9, CCND1, PPP3CA, SMAD3, RAC3, CTBP1, DKK1, TBL1X, PLCB1, CSNK1E, DAAM1, TBL1XR1, PPP3R2, BTRC, CSNK2A1, CSNK2A2, CAMK2D, PPP2CB, PPP3R1, FZD6, CAMK2G, PPP2R5C, EP300, CHP1, PPP2R5E, CREBBP, PRKCG, CSNK2B",0.7594507517174,0.262012673666569,FALSE +"A549","Input","KEGG_ABC_TRANSPORTERS",0.66076,1.96,0.00858,292,0.384,"ABCC2, ABCA1, ABCG2, ABCC8, ABCC3, ABCC1, ABCC4",2.06651271215129,0.415668775632469,FALSE +"A549","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.38087,-1.07,0.342,6338,0.697,"FLT3, TCF7L1, RELA, IKBKB, MTOR, STAT5A, TCF7L2, SOS1, MAP2K1, PIK3CD, MAP2K2, BRAF, EIF4EBP1, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PML, PIK3CB, NFKB1, AKT1, MAPK1, RUNX1, MAPK3",0.465973893943865,0.156767221901991,FALSE +"A549","Input","KEGG_ADHERENS_JUNCTION",-0.25827,-0.753,0.803,8178,0.898,"AFDN, WAS, WASF2, CTNNA1, PTPN6, FARP2, CDH1, MAPK1, ERBB2, ACTG1, MAPK3, NECTIN1, BAIAP2, NECTIN4, RAC2",0.095284454721319,0.0467236633326956,FALSE +"A549","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.28132,-0.806,0.717,6358,0.845,"ACACB, RELA, ADIPOR1, IKBKB, MTOR, TRADD, MAPK9, PRKAA1, RXRA, RXRB, NFKBIE, MAPK10, CPT1A, NFKBIA, NFKB1, AKT1, ACSL1, ACSL5, STK11",0.1444808443322,0.0731432910503077,FALSE +"A549","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.40005,-1.13,0.291,8462,0.693,"ASNS, GFPT1, ADSL, ASL, GPT2, IL4I1, ABAT, ASS1, GLUL, DDO",0.536107011014093,0.159266765388193,FALSE +"A549","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.54035,-1.53,0.0686,7844,0.943,"PIK3R1, ATP1B1, KRAS, SCNN1G, PIK3CA, ATP1A1, ATP1A4, ATP1A3, PIK3CB, ATP1B3, MAPK1, MAPK3, PDPK1, HSD11B2, SCNN1A",1.16367588429325,0.0254883072626717,FALSE +"A549","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.51331,-1.46,0.0895,9161,0.76,"PLA2G12A, PLA2G2A",1.04817696468409,0.119186407719209,FALSE +"A549","Input","KEGG_ALZHEIMERS_DISEASE",-0.21812,-0.615,0.957,8450,1,"PLCB1, FADD, COX7C, CACNA1F, CALM2, CASP3, MAPK1, MAPT, PLCB3, SNCA, CAPN1, MAPK3, MME, LPL",0.0190880622231565,0,FALSE +"A549","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.29233,-0.839,0.618,5457,0.816,"NARS2, FARSB, IARS2, SEPSECS, RARS2, SARS2, AARS2, DARS2, VARS2, WARS2, LARS2, FARSA, PARS2, TARS2, MARS2, CARS2",0.209011524911184,0.0883098412461389,FALSE +"A549","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.50313,-1.45,0.0796,7876,0.682,"GALK2, NANS, CYB5R1, GNPNAT1, GMPPB, GALE, PGM3, PGM1, GMPPA, GFPT1, HEXB, HK2, FPGT, RENBP, GCK, AMDHD2, UAP1, MPI, PGM2, HK1, GMDS",1.09908693226233,0.166215625343521,FALSE +"A549","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.37017,1.1,0.308,1061,0.599,"NEFH, PRPH, PRPH2, GPX1, NEFL, BAD, MAP2K6, BCL2L1, PPP3R1",0.511449283499556,0.222573177610689,FALSE +"A549","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.3026,-0.881,0.58,9089,0.778,"PSME2, PSME1, IFI30, CD74, B2M",0.236572006437063,0.109020403010311,FALSE +"A549","Input","KEGG_APOPTOSIS",-0.21555,-0.613,0.941,7315,1,"PIK3CD, CASP10, RIPK1, MYD88, ENDOD1, PRKAR1B, CASP7, PIK3R1, PIK3CA, NFKBIA, IRAK4, FADD, PRKAR2B, PIK3CB, CASP3, NFKB1, AKT1, IL1RAP, CAPN1, BCL2, IL1A",0.0264103765727431,0,FALSE +"A549","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.35969,-1.02,0.373,9161,0.718,"PLA2G12A, PTGS1, GPX6, GPX7, PLA2G2A, ALOX5",0.428291168191312,0.1438755557577,FALSE +"A549","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.34839,-1,0.408,8468,0.749,"LAP3, ACY1, MAOB, ASL, PRODH, PRODH2, MAOA, CKB, ARG1, ASS1, CKMT2, GLUL, ARG2, CKMT1A",0.38933983691012,0.125518182300534,FALSE +"A549","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.55562,1.63,0.0437,720,0.364,"DES, GJA1, ITGA3, CDH2, CACNA2D2, CACNA2D1, SGCD, ITGA5, ITGB1, ITGB5, ITGAV, ITGB3, ACTN1, ACTN4, ATP2A2",1.35951856302958,0.438898616350944,FALSE +"A549","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.57996,1.71,0.0382,1107,0.4,"ALDH2, ALDH1B1, UGDH, ALDH3A2",1.41793663708829,0.397940008672038,FALSE +"A549","Input","KEGG_AXON_GUIDANCE",-0.36138,-1.02,0.401,7702,0.718,"RAC1, PAK2, ABLIM3, EPHB3, GSK3B, RASA1, DPYSL5, KRAS, NRAS, ROCK1, ARHGEF12, PAK3, NCK2, NTN1, CXCR4, PAK1, EPHA4, ROBO2, LIMK2, MAPK1, PLXNA3, SLIT1, SLIT3, EPHA1, MAPK3, PLXNA2, SLIT2, PAK5, PAK6, UNC5B, NFATC2, EFNB2, RAC2",0.396855627379818,0.1438755557577,FALSE +"A549","Input","KEGG_BASAL_CELL_CARCINOMA",0.3861,1.13,0.259,907,0.616,"FZD2, FZD7, SUFU",0.586700235918748,0.210419287835575,FALSE +"A549","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.32275,0.944,0.456,852,0.749,"GTF2E1, STON1, GTF2E2",0.341035157335565,0.125518182300534,FALSE +"A549","Input","KEGG_BASE_EXCISION_REPAIR",0.38329,1.13,0.27,2845,0.616,"NEIL2, POLL, POLE3, POLE4, NTHL1, XRCC1, POLD4, POLD3, POLD1, POLB, MPG, POLD2, TDG, MBD4",0.568636235841013,0.210419287835575,FALSE +"A549","Input","KEGG_BETA_ALANINE_METABOLISM",0.3743,1.12,0.256,1107,0.597,"ALDH2, ALDH1B1, ALDH3A2",0.59176003468815,0.224025668870631,FALSE +"A549","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.59604,1.74,0.0321,943,0.427,"SCD5, HACD1, ACOT2, ELOVL5, FADS1, FADS2, PECR",1.49349496759513,0.369572124974976,FALSE +"A549","Input","KEGG_BLADDER_CANCER",-0.31342,-0.894,0.571,7636,0.771,"MAP2K2, BRAF, RASSF1, RAF1, THBS1, TYMP, KRAS, NRAS, E2F1, CDH1, MAPK1, RPS6KA5, CDKN2A, ERBB2, MAPK3",0.243363891754152,0.112945621949043,FALSE +"A549","Input","KEGG_BUTANOATE_METABOLISM",-0.37138,-1.06,0.351,8830,0.704,"ACAT2, AACS, ABAT, HMGCS2, OXCT1, BDH1",0.454692883534176,0.152427340857888,FALSE +"A549","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.52515,-1.5,0.079,7558,0.943,"NFKBIE, MAP2K2, RAC1, VAV2, GSK3B, RAF1, PIK3R1, KRAS, NRAS, VAV1, BTK, PIK3CA, PLCG2, PTPN6, BCL10, NFKBIA, VAV3, CD79B, PIK3CB, NFKB1, AKT1, MAPK1, INPP5D, MAPK3, FOS, SYK, CARD11, NFATC2, DAPP1, RAC2",1.10237290870956,0.0254883072626717,FALSE +"A549","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.38447,1.17,0.241,1261,0.602,"CD38, MYLK, BST1, PLCB4, PRKCG, ITPR1, ATP2B1, PRKCB, PLCD3, ATP2A2, TACR1, ADCY3, ADCY8, PPP3R1, SPHK2, GNAQ, PHKA1, PRKACA, PRKCA",0.617982957425132,0.220403508742175,FALSE +"A549","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.42487,1.26,0.192,803,0.603,"TPM2, TPM1, CACNA2D2, CACNA2D1, ATP2A2, TPM4",0.71669877129645,0.219682687859849,FALSE +"A549","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.40097,-1.14,0.257,9212,0.687,"ICOSLG, SDC3, NCAM1, NECTIN1, ITGAL, SDC2, ITGB8, CLDN11, CDH15, CDH3, CLDN3, CLDN7, CLDN4, CLDN18",0.590066876668705,0.16304326294045,FALSE +"A549","Input","KEGG_CELL_CYCLE",0.20691,0.617,0.958,2255,0.968,"CDKN1A, TGFB2, MDM2, CCNB3, ANAPC11, ANAPC10, SMAD3, SMAD2, ATR, YWHAQ, PRKDC, STAG1, CCND1, ATM, CDC26, CDK6, CDC25B, TFDP2, ORC5, ANAPC4, BUB3, CDK4, MAD1L1, CDKN1B, CDC27",0.0186344909214556,0.0141246426916063,FALSE +"A549","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.33049,-0.953,0.474,7315,0.77,"PIK3CD, GNAI2, PREX1, CCR4, PTK2B, RAP1B, CCL13, GRK6, BRAF, RAC1, VAV2, GSK3B, RAF1, GRK5, PIK3R1, CCL15, KRAS, NRAS, VAV1, PIK3CA, ROCK1, PLCB2, WAS, NFKBIA, VAV3, PRKCD, PLCB1, CXCR4, CRKL, PAK1, PIK3CB, GNG10, ARRB1, NFKB1, AKT1, MAPK1, GNG2, GRK2, PLCB3, GNG5, PRKCZ, MAPK3, STAT2, RAC2",0.324221658325915,0.113509274827518,FALSE +"A549","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.27277,-0.787,0.725,7636,0.853,"MAP2K2, BRAF, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, HDAC1, CBLB, NFKBIA, E2F1, CRKL, PIK3CB, NFKB1, AKT1, MAPK1, BCR, CDKN2A, RUNX1, MAPK3, CBL, MECOM",0.139661993429006,0.069050968832477,FALSE +"A549","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.62733,-1.79,0.0153,9641,0.505,"PER3",1.8153085691824,0.296708621881339,FALSE +"A549","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.17608,-0.507,0.995,6120,1,"PCK2, CS, ACO1, MDH2, SUCLA2, OGDHL, IDH1, DLD, OGDH, ACO2, MDH1, DLAT, IDH2",0.00217691925427455,0,FALSE +"A549","Input","KEGG_COLORECTAL_CANCER",-0.30952,-0.9,0.57,7566,0.789,"MAPK10, BRAF, RAC1, GSK3B, RAF1, CTNNB1, PIK3R1, KRAS, PIK3CA, PIK3CB, CASP3, AKT1, MAPK1, BIRC5, MAPK3, FOS, BCL2, RAC2",0.244125144327509,0.10292299679058,FALSE +"A549","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.55397,1.66,0.0255,1069,0.366,"FGA, C1S, THBD, C9, SERPINE1, PLAUR, SERPIND1, TFPI, PLAU, MASP1, CD59, C1R, F3",1.59345981956604,0.436518914605589,FALSE +"A549","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.32168,-0.919,0.514,8482,0.78,"CBS, ENOPH1, IL4I1, MTAP, CTH",0.289036881004724,0.10790539730952,FALSE +"A549","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33143,0.989,0.404,1199,0.718,"TGFB2, CXCL5, EDAR, OSMR, TNFRSF10D, TGFBR2, TNFRSF12A, TGFBR1, TNFRSF10C, KITLG, CD70, TNFRSF10A, ACVR1, IL18, TNFRSF10B, ACVR1B, IL6ST, CD40",0.393618634889395,0.1438755557577,FALSE +"A549","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.32311,-0.931,0.494,9447,0.774,"DDX58, RIPK3, CASP1",0.306273051076353,0.111259039317107,FALSE +"A549","Input","KEGG_DILATED_CARDIOMYOPATHY",0.615,1.83,0.0211,911,0.471,"TPM2, DES, TPM1, ITGA3, TGFB2, CACNA2D2, CACNA2D1, SGCD, ITGA5, ITGB1, ITGB5, ITGAV, ITGB3, ATP2A2, TPM4, ADCY3, ADCY8, ITGA1",1.67571754470231,0.326979092871104,FALSE +"A549","Input","KEGG_DNA_REPLICATION",0.24818,0.718,0.843,2823,0.936,"POLE3, POLE4, RNASEH1, POLA2, POLD4, POLD3, SSBP1, POLD1, POLA1, PRIM2, POLD2, PRIM1, RNASEH2A",0.0741724253752577,0.0287241512618947,FALSE +"A549","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.49682,-1.41,0.119,7112,0.557,"SOS1, MAP2K1, ETV6, KRAS, NOTCH2, MAPK1, MAPK3",0.924453038607469,0.254144804826271,FALSE +"A549","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.50471,-1.43,0.0918,8431,0.644,"GSTA2, UGT2B17, MAOB, FMO2, FMO4, FMO5, ALDH1A3, MAOA, GSTM3, ADH4, ADH7, ADH1C, GSTM4",1.03715731879876,0.191114132640188,FALSE +"A549","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.36841,-1.07,0.318,5976,0.697,"UGT2B11, UGT2B4, UCK2, HPRT1, GUSB, NAT1, ITPA, UPP1, UCKL1, XDH, TYMP, CES1, CES2, TPMT, UGT2B17",0.497572880015567,0.156767221901991,FALSE +"A549","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.46992,1.37,0.115,402,0.515,"COL5A2, COL4A1, COL5A1, COL4A2, ITGA3, ITGA5, ITGB1, ITGB5, LAMB1, CD44, ITGAV, FN1, ITGB3, SPP1",0.939302159646388,0.288192770958809,FALSE +"A549","Input","KEGG_ENDOCYTOSIS",-0.23839,-0.671,0.88,8085,0.994,"PRKCI, PARD6A, ARFGAP2, DNM2, RAB22A, CBLB, RNF41, RAB11B, DNAJC6, CXCR4, VPS37B, CHMP4A, CHMP4B, SH3GLB1, ARRB1, VPS4B, ARAP1, ACAP2, GRK2, CHMP4C, ERBB4, PRKCZ, FGFR2, SH3GL2, LDLR, CBL, ARAP2, RAB11FIP4, ERBB3, PSD4, EPN3",0.0555173278498314,0.00261361560268669,FALSE +"A549","Input","KEGG_ENDOMETRIAL_CANCER",-0.36937,-1.07,0.345,7636,0.697,"MAP2K2, BRAF, GSK3B, RAF1, CTNNB1, PIK3R1, CTNNA2, KRAS, NRAS, PIK3CA, CTNNA1, PIK3CB, CDH1, AKT1, MAPK1, ERBB2, MAPK3, PDPK1",0.462180904926726,0.156767221901991,FALSE +"A549","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.48793,-1.41,0.0975,7392,0.557,"TCIRG1, ATP6V0C, ATP6V0D1, MAPK10, RAC1, ATP6V0A1, MAPK14, PLCG2, ATP6AP1, ATP6V1C1, F11R, ATP6V1E1, NFKBIA, ATP6V1B2, ATP6V1F, PAK1, ATP6V1A, CASP3, NFKB1, ATP6V1H, ATP6V1D, ATP6V1B1, ATP6V1G1, MAPK12",1.01099538430146,0.254144804826271,FALSE +"A549","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.28073,-0.803,0.689,7566,0.831,"MAPK10, AREG, MAP2K2, BRAF, EIF4EBP1, PAK2, GSK3B, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PAK3, PLCG2, NCK2, CBLB, CRKL, PAK1, PIK3CB, AKT1, MAPK1, ERBB2, ERBB4, MAP2K7, MAPK3, CBL, PAK5, PAK6, ERBB3",0.161780778092374,0.080398976215889,FALSE +"A549","Input","KEGG_ETHER_LIPID_METABOLISM",0.37443,1.12,0.282,1996,0.597,"PLPP1, PLA2G4A, PLPP3, CHPT1, PLD2, PLPP2, AGPS",0.549750891680639,0.224025668870631,FALSE +"A549","Input","KEGG_FATTY_ACID_METABOLISM",-0.46214,-1.35,0.133,8234,0.605,"ALDH9A1, CPT1A, ACADM, ACAT2, ACSL1, GCDH, CPT2, ADH4, ADH7, ACSL5, ADH1C",0.876148359032914,0.218244625347531,FALSE +"A549","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.49999,-1.44,0.0911,7090,0.662,"MAPK9, SOS1, MAP2K1, PIK3CD, GAB2, MAP2K3, MAPK10, MAP2K2, RAC1, VAV2, RAF1, PIK3R1, KRAS, NRAS, VAV1, BTK, PIK3CA, MAPK14, PLCG2, VAV3, PRKCD, PIK3CB, AKT1, MAPK1, INPP5D, MAP2K7, PLA2G12A, MAPK3, PDPK1, SYK, PLA2G2A, MAPK12, RAC2",1.040481623027,0.1791420105603,FALSE +"A549","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.29827,-0.846,0.66,7702,0.811,"RAC1, VAV2, RAF1, PIK3R1, VAV1, PTPRC, PIK3CA, WAS, WASF2, DNM2, PLCG2, VAV3, PRKCD, SPHK1, CRKL, PAK1, PIK3CB, GSN, LIMK2, AKT1, MAPK1, INPP5D, AMPH, MARCKSL1, MAPK3, SYK, SCIN, RAC2",0.180456064458131,0.090979145788844,FALSE +"A549","Input","KEGG_FOCAL_ADHESION",0.36156,1.04,0.355,991,0.646,"COL5A2, COL4A1, COL5A1, COL4A2, CAV2, MYLK, ITGA3, ITGA5, ITGB1, ITGB5, AKT3, FLNB, LAMB1, PRKCG, ITGAV, FN1, SRC, ITGB3, SPP1, ZYX, FLNA, ACTN1, ACTN4, CAV1, PPP1R12A, PRKCB, PARVA, LAMA5, ILK, BAD, ITGA1, IGF1R, PARVB",0.449771646944906,0.189767482004916,FALSE +"A549","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.77497,-2.21,0.0018,9658,0.229,"ALPI, ALPP, ALPG",2.74472749489669,0.640164517660112,TRUE +"A549","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.46754,-1.34,0.133,8420,0.603,"GMPPA, ALDOB, FBP2, HK2, FPGT, FBP1, PFKFB2, PFKFB4, MPI, PFKL, HK1, GMDS, ALDOC",0.876148359032914,0.219682687859849,FALSE +"A549","Input","KEGG_GALACTOSE_METABOLISM",-0.35035,-0.996,0.409,7649,0.733,"PFKM, GALK2, GALE, PGM1, HK2, GCK, PGM2, PFKL, HK1",0.388276691992658,0.134896025358872,FALSE +"A549","Input","KEGG_GAP_JUNCTION",0.4356,1.29,0.153,1261,0.574,"GJA1, PLCB4, PRKCG, TUBB2B, LPAR1, SRC, TJP1, GNAI1, ITPR1, TUBA4A, PRKCB, ADCY3, ADCY8, GNAQ, PRKACA, PRKCA",0.815308569182401,0.241088107602027,FALSE +"A549","Input","KEGG_GLIOMA",0.25313,0.746,0.82,1564,0.954,"CDKN1A, AKT3, PRKCG, MDM2, PRKCB, IGF1R, PRKCA, PIK3R2, CCND1",0.0861861476162833,0.0204516252959049,FALSE +"A549","Input","KEGG_GLUTATHIONE_METABOLISM",-0.34838,-0.998,0.42,8014,0.741,"GGT7, GSTM1, OPLAH, GSTA2, RRM2, LAP3, GPX3, IDH2, GGCT, GSTM3, GPX6, GPX7, GSTM4",0.3767507096021,0.130181792020672,FALSE +"A549","Input","KEGG_GLYCEROLIPID_METABOLISM",0.28138,0.839,0.651,491,0.86,"AKR1B1, ALDH2, ALDH1B1, PLPP1, PLPP3",0.186419011431808,0.0655015487564323,FALSE +"A549","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.27319,-0.803,0.718,8081,0.831,"PEMT, ETNK1, PISD, MBOAT1, DGKH, DGKQ, PLA2G15, PLA2G12A, CHKB, LYPLA2, CDS1, PLA2G2A, PCYT2",0.1438755557577,0.080398976215889,FALSE +"A549","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.31233,0.918,0.471,564,0.772,"GLDC, PIPOX, GAMT",0.326979092871104,0.112382699664264,FALSE +"A549","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.40878,-1.17,0.25,8234,0.745,"ALDH9A1, ACSS1, PGM1, DLAT, ALDOB, FBP2, HK2, FBP1, GCK, ALDH1A3, ADH4, ADH7, PGM2, PFKL, ACSS2, HK1, ADH1C, ALDOC",0.602059991327962,0.127843727251707,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.47409,-1.36,0.142,9330,0.609,"CSGALNACT1, UST",0.847711655616944,0.215382707367125,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.2526,0.741,0.804,2787,0.945,"NDST1, B3GALT6, EXTL2, B3GAT3",0.0947439512515487,0.0245681914907371,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.39167,-1.09,0.316,8587,0.724,"B4GALT3, ST3GAL2, ST3GAL1",0.500312917381596,0.140261433802853,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.25406,-0.724,0.815,7713,0.937,"IDS, GNS, SGSH, HEXB, HPSE",0.0888423912600234,0.0282604091122217,FALSE +"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.50834,-1.47,0.0712,8748,0.864,"HEXB, ST3GAL2, ST3GAL1",1.14752000636314,0.0634862575211067,FALSE +"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.6881,-1.98,0.0109,8748,0.244,"HEXB, NAGA, ST3GAL2, ST3GAL1",1.96257350205938,0.612610173661271,TRUE +"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.49259,-1.42,0.105,9433,0.628,"FUT3, ST3GAL4, B3GNT3",0.978810700930062,0.202040356262804,FALSE +"A549","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.51744,1.52,0.0922,2983,0.408,"PIGB, PIGX, PIGG, PIGQ, PIGH, PIGO, PIGW, PIGN",1.03526907894637,0.38933983691012,FALSE +"A549","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.51685,-1.47,0.0924,7465,0.864,"PGP, GLYCTK, MTHFD2L, ACO2, MDH1, HYI, AFMID",1.03432802877989,0.0634862575211067,FALSE +"A549","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.31728,-0.899,0.561,7470,0.771,"PTK2B, MAP2K3, MAPK10, MAP3K4, MAP2K2, RAF1, KRAS, NRAS, CALML3, PLCB2, MAPK14, PRKCD, PLCB1, MAP3K3, CACNA1F, CALM2, MAPK1, PLCB3, MAP2K7, PLA2G12A, MAPK3, PLA2G2A, MMP14, MAPK12",0.251037138743839,0.112945621949043,FALSE +"A549","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.20165,-0.567,0.98,7757,1,"GSK3B, WNT5B, CSNK1A1",0.00877392430750515,0,FALSE +"A549","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.50287,1.47,0.0958,911,0.451,"CD38, ITGA3, ITGA5, CD44, ITGB3, KITLG, CD59, ITGA1",1.01863449092146,0.345823458122039,FALSE +"A549","Input","KEGG_HISTIDINE_METABOLISM",0.3877,1.16,0.225,316,0.6,"ALDH3A1, ALDH3B1, ALDH2, ALDH1B1",0.647817481888638,0.221848749616356,FALSE +"A549","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.47319,1.4,0.101,2666,0.497,"RAD54L, BRCA2, EME1, MUS81, NBN, BLM, RAD54B, POLD4, POLD3, SSBP1, POLD1, TOP3A, RAD51C, POLD2",0.995678626217357,0.303643611266668,FALSE +"A549","Input","KEGG_HUNTINGTONS_DISEASE",0.21392,0.642,0.916,3502,0.976,"TGM2, PLCB4, GPX1, ITPR1, POLR2D, AP2A2, GNAQ, HIP1, NDUFA2, BBC3, CLTA, SDHC, POLR2L, AP2M1, SDHA, POLR2I, AP2S1, SDHB, ATP5PF, SDHD, NDUFS6, POLR2E, SLC25A6, NDUFV3, POLR2G, UQCRFS1, CLTC, NDUFB2, NDUFA10, NDUFV1, NDUFA7, NDUFA5, SLC25A4, NDUFS1, AP2A1, BAX, COX6B1, DNAL1, DCTN1, NDUFB9, NDUFS5, NDUFB7, COX7A2L, VDAC1, AP2B1, NDUFS4, DCTN2, NDUFB3, HAP1",0.0381045263321496,0.0105501823333082,FALSE +"A549","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.58381,1.77,0.0275,911,0.467,"TPM2, DES, TPM1, ITGA3, TGFB2, CACNA2D2, CACNA2D1, SGCD, ITGA5, ITGB1, ITGB5, ITGAV, ITGB3, ATP2A2, TPM4, ITGA1",1.56066730616974,0.330683119433888,FALSE +"A549","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.3942,-1.12,0.285,7200,0.701,"PIP5K1A, PIK3CD, TPI1, INPPL1, ISYNA1, ALDH6A1, PIK3C3, PIK3CA, PLCB2, PLCG2, ITPKA, PLCB1, ITPK1, PIK3CB, PIK3C2B, PI4KB, SYNJ1, INPP5B, IMPA2, PLCB3",0.54515513999149,0.154281982033341,FALSE +"A549","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.32829,-0.952,0.467,7090,0.761,"MAPK9, SOS1, MAP2K1, PRKAA1, PTPN1, PIK3CD, SORBS1, MKNK1, RAPGEF1, MAPK10, PHKG2, MAP2K2, BRAF, EIF4EBP1, PRKAR1B, GSK3B, RAF1, PIK3R1, KRAS, NRAS, PRKCI, PIK3CA, CALML3, CBLB, GYS1, PRKAR2B, CRKL, PIK3CB, CALM2, AKT1, MAPK1, FBP2, HK2, FOXO1, FBP1, GCK, INPP5D, PRKCZ, PPP1R3D, MAPK3, PDPK1, CBL, HK1",0.330683119433888,0.118615343229427,FALSE +"A549","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.39955,-1.14,0.271,6996,0.687,"IL15RA, IL6, CXCR4, TNFSF13B, ICOSLG",0.567030709125594,0.16304326294045,FALSE +"A549","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.34543,-0.967,0.467,7571,0.762,"IL6, SPRED2, PIK3R1, LIFR, PIK3CA, CBLB, PTPN6, IFNAR1, STAT6, PIK3CB, SPRY4, AKT1, IRF9, STAT2, EPO, CBL, PRLR, SPRY1",0.330683119433888,0.1180450286604,FALSE +"A549","Input","KEGG_LEISHMANIA_INFECTION",-0.40968,-1.16,0.244,8229,0.728,"MAPK14, PTPN6, NFKBIA, IRAK4, NFKB1, MAPK1, MARCKSL1, MAPK3, FOS, IL1A, MAPK12",0.612610173661271,0.137868620686963,FALSE +"A549","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.47542,-1.33,0.144,7702,0.6,"RAC1, VAV2, ITGB2, CTNNB1, PIK3R1, CTNNA2, VAV1, OCLN, PIK3CA, ROCK1, AFDN, MAPK14, PLCG2, F11R, CTNNA1, RASSF5, VAV3, CXCR4, PIK3CB, ICAM1, ACTG1, ITGAL, CLDN11, CLDN3, MAPK12, CLDN7, RAC2, CLDN4, CLDN18",0.84163750790475,0.221848749616356,FALSE +"A549","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.52094,1.55,0.0406,1107,0.442,"ALDH2, ALDH1B1, ALDH3A2",1.39147396642281,0.354577730650908,FALSE +"A549","Input","KEGG_LONG_TERM_DEPRESSION",0.27085,0.791,0.722,1261,0.881,"PLCB4, PRKCG, PLA2G4A, GNAI1, ITPR1, PRKCB, GNA13, IGF1R, GNAQ, PRKCA",0.141462802430361,0.0550240915879521,FALSE +"A549","Input","KEGG_LONG_TERM_POTENTIATION",0.28298,0.829,0.65,1261,0.833,"PLCB4, PRKCG, ITPR1, PPP1R12A, PRKCB, ADCY8, PPP3R1, GNAQ, PRKACA, PRKCA",0.187086643357144,0.0793549985932124,FALSE +"A549","Input","KEGG_LYSINE_DEGRADATION",0.36706,1.1,0.299,316,0.599,"PLOD2, PIPOX, ALDH2, ALDH1B1",0.52432881167557,0.222573177610689,FALSE +"A549","Input","KEGG_LYSOSOME",-0.40736,-1.18,0.239,7182,0.742,"MAN2B1, AP3M2, NEU1, PPT2, SUMF1, TCIRG1, ATP6V0C, ATP6V0D1, SMPD1, IGF2R, IDS, GNS, ATP6V0A1, AP1S1, SGSH, SCARB2, GGA2, NPC2, ATP6AP1, CTSH, SLC11A2, CTSK, CTSO, LIPA, PPT1, HEXB, SLC17A5, DNASE2, SORT1, GGA1, ATP6V1H, FUCA1, AP1B1, PLA2G15, CLN5, NAGA, GM2A, LAMP1, CTSC, AP1M2, CTSE, MANBA, LAMP3, LAPTM5",0.621602099051862,0.129596094720973,FALSE +"A549","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.23817,-0.679,0.883,8501,0.995,"MAPKAPK2, MAP3K5, CRKL, MAP3K3, PAK1, CACNA1F, DUSP10, CASP3, ARRB1, RPS6KA4, NFKB1, AKT1, MAPK1, RPS6KA5, MAPT, LAMTOR3, STMN1, MAPKAPK3, MAP4K2, MAP2K7, FGFR2, PLA2G12A, MAPK3, FOS, RPS6KA1, NFATC2, PLA2G2A, IL1A, MECOM, MAPK12, RAC2",0.0540392964224314,0.00217691925427455,FALSE +"A549","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.3633,-1.05,0.357,8892,0.714,"HES1, GCK, IAPP",0.447331783887807,0.146301788223826,FALSE +"A549","Input","KEGG_MELANOGENESIS",0.33522,0.986,0.394,1261,0.707,"FZD2, PLCB4, PRKCG, GNAI1, PRKCB, FZD7, KITLG, ADCY3, ADCY8, MITF, GNAQ, PRKACA, PRKCA",0.404503778174426,0.150580586203101,FALSE +"A549","Input","KEGG_MELANOMA",0.43539,1.29,0.167,977,0.574,"FGF13, FGF2, CDKN1A, AKT3, MDM2, BAD, MITF, IGF1R",0.777283528852417,0.241088107602027,FALSE +"A549","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.41251,1.24,0.188,318,0.614,"AKR1C2, ALDH3A1, AKR1C1, ALDH3B1, AKR1C3, CYP2S1",0.72584215073632,0.211831628858832,FALSE +"A549","Input","KEGG_MISMATCH_REPAIR",-0.21391,-0.609,0.942,2094,0.99,"PMS2, POLD4, POLD3, SSBP1, MSH6, POLD1, POLD2, MSH3, MSH2, MLH1, RPA1, PCNA, RPA2, RFC1, RPA3, RFC2, RFC5, RFC4, RFC3, LIG1, EXO1",0.0259490972071227,0.00436480540245009,FALSE +"A549","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.38951,-1.11,0.306,7644,0.693,"BRAF, EIF4EBP1, PIK3R1, PIK3CA, CAB39L, PIK3CB, AKT1, MAPK1, CAB39, MAPK3, PDPK1, RPS6KA1, STK11",0.51427857351842,0.159266765388193,FALSE +"A549","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.43024,-1.22,0.215,7636,0.686,"MAP2K2, BRAF, RAC1, VAV2, RAF1, ITGB2, PIK3R1, MICA, KRAS, NRAS, VAV1, PIK3CA, PLCG2, PTPN6, IFNAR1, VAV3, RAET1L, ULBP2, PAK1, PIK3CB, ICAM1, CASP3, MAPK1, SH3BP2, MAPK3, LCK, ITGAL, SYK, NFATC2, RAC2",0.667561540084395,0.163675884293248,FALSE +"A549","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.29375,-0.835,0.651,9000,0.815,"PRSS2, HCRTR1, TSPO, PRLR",0.186419011431808,0.0888423912600234,FALSE +"A549","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.44965,-1.32,0.147,7498,0.598,"RAP1B, RAPGEF1, NFKBIE, MAPK10, MAP2K2, BRAF, RAC1, GSK3B, RAF1, ARHGDIA, PIK3R1, KRAS, NRAS, FRS2, PIK3CA, CALML3, MAPK14, PLCG2, NFKBIA, PRKCD, IRAK4, MAPKAPK2, MAP3K5, CRKL, MAP3K3, NGFR, PIK3CB, CALM2, RPS6KA4, NFKB1, AKT1, MAPK1, RPS6KA5, SORT1, MAP2K7, MAPK3, PDPK1, ARHGDIB, RPS6KA1, BCL2, MAPK12",0.832682665251824,0.223298816011589,FALSE +"A549","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.45827,1.34,0.118,163,0.537,"NNMT, CD38, BST1",0.928117992693875,0.270025714300444,FALSE +"A549","Input","KEGG_NITROGEN_METABOLISM",0.40232,1.18,0.257,667,0.604,"CPS1, GLUD2, CA12, CA8, GLS, GLS2",0.590066876668705,0.218963061378868,FALSE +"A549","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.59547,-1.7,0.0336,8767,0.542,"NFKB1, MAPK1, MAPK3, CASP1, MAPK12, CASP5",1.47366072261016,0.266000713461613,FALSE +"A549","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.40184,1.2,0.217,2300,0.614,"PRKDC, POLL, DCLRE1C, LIG4",0.66354026615147,0.211831628858832,FALSE +"A549","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.32196,-0.921,0.51,7112,0.786,"SOS1, MAP2K1, PIK3CD, RXRA, RXRB, MAP2K2, BRAF, RASSF1, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PLCG2, RASSF5, E2F1, PIK3CB, AKT1, MAPK1, CDKN2A, ERBB2, MAPK3, PDPK1",0.292429823902064,0.104577453960592,FALSE +"A549","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.35897,1.08,0.302,734,0.62,"JAG1, NUMBL, JAG2, NCOR2, DTX2",0.519993057042849,0.207608310501746,FALSE +"A549","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.32436,0.983,0.44,3620,0.696,"DDB2, ERCC8, XPC, CETN2, POLE3, ERCC1, POLE4, POLD4, GTF2H1, POLD3, GTF2H5, POLD1, CCNH, POLD2, GTF2H2, ERCC2, MNAT1, CDK7, GTF2H3, CUL4B, GTF2H4, XPA, RPA1, POLE2, ERCC3",0.356547323513813,0.157390760389438,FALSE +"A549","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.22791,-0.647,0.929,7192,1,"MGAT1, ALG9, STT3A, ALG6, ALG11, MGAT3, MGAT5, B4GALT3, MGAT4B, MAN1A1, ST6GAL1",0.0319842860063582,0,FALSE +"A549","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.40274,-1.16,0.263,8145,0.728,"CALML3, CALM2, PRKG2, CLCA2",0.580044251510242,0.137868620686963,FALSE +"A549","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.36659,-1.02,0.37,6727,0.718,"GART, MTR, SHMT1, DHFR, MTHFD2L, MTHFR, AMT, TYMS, ALDH1L1",0.431798275933005,0.1438755557577,FALSE +"A549","Input","KEGG_OOCYTE_MEIOSIS",-0.26978,-0.77,0.738,7793,0.876,"PPP2R5B, CDK2, AURKA, CCNB1, MOS, CALML3, SMC1A, SMC3, CALM2, PPP2R1B, PLK1, CDK1, MAPK1, PPP2R5A, PTTG1, MAPK3, RPS6KA1, MAPK12",0.131943638176958,0.0574958938319193,FALSE +"A549","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.43545,-1.22,0.205,6677,0.686,"AGA, GBA, MAN2B1, NEU1, MAN2B2, FUCA2, HEXB, FUCA1, MANBA",0.688246138944246,0.163675884293248,FALSE +"A549","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.21682,-0.626,0.934,6657,1,"COX6C, NDUFB5, NDUFB1, ATP5F1C, CYC1, ATP5PB, COX7A2, ATP5MG, TCIRG1, ATP6V0C, ATP6V0D1, PPA2, ATP6V0A1, PPA1, ATP6AP1, ATP6V1C1, ATP6V1E1, ATP6V1B2, ATP6V1F, COX7C, ATP6V1A, ATP12A, ATP6V1H, ATP6V1D, ATP6V1B1, ATP6V1G1",0.0296531237699066,0,FALSE +"A549","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.36079,-1.03,0.376,8426,0.733,"GALNT5, GALNT12, ST6GALNAC1, ST3GAL2, GCNT1, ST3GAL1, GALNT6, GALNT3",0.424812155072339,0.134896025358872,FALSE +"A549","Input","KEGG_P53_SIGNALING_PATHWAY",0.28525,0.867,0.635,542,0.834,"TP53I3, CDKN1A, SERPINE1, MDM2, ZMAT3, CCNB3, DDB2",0.197226274708024,0.0788339493622613,FALSE +"A549","Input","KEGG_PANCREATIC_CANCER",-0.31114,-0.89,0.567,7566,0.77,"MAPK10, BRAF, RAC1, RAF1, PIK3R1, RALBP1, KRAS, PIK3CA, RALA, E2F1, PIK3CB, ARHGEF6, NFKB1, AKT1, MAPK1, CDKN2A, ERBB2, RAD51, MAPK3, RAC2",0.246416941107093,0.113509274827518,FALSE +"A549","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.3068,-0.878,0.584,7354,0.775,"COASY, PANK3, PANK4, PPCS",0.233587152887601,0.11069829749369,FALSE +"A549","Input","KEGG_PARKINSONS_DISEASE",-0.13765,-0.395,1,8618,1,"COX7C, CASP3, SNCA, UBE2L6, UBA7",0,0,FALSE +"A549","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.22644,0.67,0.925,1500,0.975,"ITGB1, TUBB2B, TUBA4A, YWHAQ, PRKCA, CD14, TUBB6, ACTB",0.0338582672609674,0.0109953843014632,FALSE +"A549","Input","KEGG_PATHWAYS_IN_CANCER",0.29415,0.862,0.605,1020,0.828,"FGF13, FGF2, COL4A1, FZD2, CDKN1A, COL4A2, ITGA3, TGFB2, ITGB1, AKT3, LAMB1, PRKCG, ITGAV, FN1, MDM2, DAPK3, TGFBR2, AR, DAPK1, PRKCB, TGFBR1, FZD7, KITLG, LAMA5, EGLN1, BAD, SUFU, MITF, IGF1R, SMAD3, BCL2L1",0.218244625347531,0.0819696632151199,FALSE +"A549","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.39768,1.21,0.188,747,0.619,"AKR1B1, UGDH",0.72584215073632,0.208309350979882,FALSE +"A549","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.44452,-1.26,0.177,8377,0.709,"PGM1, ALDOB, PGLS, FBP2, FBP1, PGM2, PFKL, ALDOC",0.752026733638193,0.149353764816933,FALSE +"A549","Input","KEGG_PEROXISOME",-0.22017,-0.624,0.941,8477,1,"FAR2, FAR1, PXMP4, PMVK, ACSL1, ABCD1, IDH2, ACSL5, NUDT12, DDO",0.0264103765727431,0,FALSE +"A549","Input","KEGG_PHENYLALANINE_METABOLISM",0.41027,1.21,0.222,222,0.619,"ALDH3A1, ALDH3B1",0.653647025549361,0.208309350979882,FALSE +"A549","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.34104,-0.966,0.429,8099,0.753,"PIK3C3, PIK3CA, CALML3, PLCB2, PLCG2, ITPKA, PLCB1, ITPK1, PIK3CB, DGKH, CALM2, PIK3C2B, PI4KB, SYNJ1, INPP5B, IMPA2, DGKQ, PLCB3, INPP5D, CDS1",0.367542707815276,0.123205023799299,FALSE +"A549","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.28214,0.833,0.667,1831,0.841,"HMOX1, COX15, CPOX, FECH, HCCS",0.175874166083451,0.0752040042020878,FALSE +"A549","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.47291,-1.38,0.132,8533,0.593,"ACADM, FABP1, FABP2, ACSL1, SCD, CYP27A1, CPT2, DBI, GK, PDPK1, HMGCS2, FABP6, ACSL5, PLTP, LPL",0.87942606879415,0.226945306635737,FALSE +"A549","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.316,-0.899,0.541,7958,0.771,"TAP2, BTK, PTPRC, LCK",0.266802734893431,0.112945621949043,FALSE +"A549","Input","KEGG_PRION_DISEASES",-0.32726,-0.949,0.485,8788,0.757,"MAPK1, MAPK3, NCAM1, IL1A",0.314258261397736,0.120904120499927,FALSE +"A549","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.29023,-0.833,0.638,7090,0.801,"MAPK9, MAP2K1, HSP90AB1, PIK3CD, GNAI2, PKMYT1, CCNA2, MAPK10, BRAF, RAF1, CDK2, PIK3R1, CCNB1, KRAS, PIK3CA, MOS, MAPK14, PIK3CB, FZR1, PLK1, CDK1, AKT1, MAPK1, MAPK3, RPS6KA1, MAPK12",0.195179321278838,0.0963674839157623,FALSE +"A549","Input","KEGG_PROPANOATE_METABOLISM",-0.32193,-0.904,0.543,7870,0.791,"PCCA, ACSS3, ALDH6A1, ALDH9A1, ACSS1, ACADM, ACAT2, ABAT, ACSS2",0.265200170411153,0.101823516502323,FALSE +"A549","Input","KEGG_PROSTATE_CANCER",-0.32041,-0.915,0.535,7112,0.779,"SOS1, MAP2K1, HSP90AB1, CREB5, PIK3CD, GSTP1, MAP2K2, BRAF, GSK3B, RAF1, CDK2, CTNNB1, PIK3R1, CREB3L2, KRAS, NRAS, PIK3CA, PDGFC, NFKBIA, E2F1, PIK3CB, NFKB1, AKT1, MAPK1, ERBB2, FOXO1, FGFR2, MAPK3, PDPK1, BCL2",0.271646217978772,0.108462542327436,FALSE +"A549","Input","KEGG_PROTEASOME",-0.36966,-1.04,0.379,9089,0.723,"PSME2, PSME1, PSMB8, PSMB10",0.421360790031928,0.140861702705469,FALSE +"A549","Input","KEGG_PROTEIN_EXPORT",0.18109,0.529,0.991,479,0.991,"SEC61A2",0.00392634551472468,0.00392634551472468,FALSE +"A549","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.4405,-1.24,0.208,7927,0.708,"ATP1B1, MDH1, ATP1A1, ATP1A4, ATP1A3, ATP1B3, SLC38A3, CA2",0.681936665037238,0.149966742310231,FALSE +"A549","Input","KEGG_PURINE_METABOLISM",0.24822,0.708,0.855,2719,0.937,"NME4, PDE4D, PAPSS2, ADA, POLR2D, PFAS, ADCY3, ADCY8, NPR2, POLR1E, PDE6C, NT5C, PDE8A, POLE3, POLE4, PKM, ENPP1, POLR2L, PRPS1, PRPS1L1, POLR3H, RRM2B, POLR2I, PDE1C, PDE8B, POLR3D, POLA2, POLD4, POLD3, AK4, PKLR, POLD1, POLR2E, NME2, NME1, POLA1, POLR2G, PRIM2, PNPT1, POLD2, PRIM1",0.0680338852718274,0.0282604091122217,FALSE +"A549","Input","KEGG_PYRIMIDINE_METABOLISM",0.23836,0.719,0.854,2719,0.95,"NME4, CTPS1, POLR2D, CDA, POLR1E, NT5C, TXNRD1, POLE3, POLE4, POLR2L, POLR3H, RRM2B, POLR2I, POLR3D, POLA2, POLD4, POLD3, CAD, POLD1, POLR2E, NME2, NME1, POLA1, POLR2G, PRIM2, PNPT1, POLD2, PRIM1",0.068542129310995,0.0222763947111523,FALSE +"A549","Input","KEGG_PYRUVATE_METABOLISM",0.28395,0.837,0.636,2381,0.848,"AKR1B1, ALDH2, ALDH1B1, ME3, ALDH3A2, PKM, HAGH, GRHPR, ME2, ALDH7A1, LDHA, PC, PKLR",0.196542884351586,0.0716041477432862,FALSE +"A549","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.24462,0.737,0.802,911,0.936,"FGF13, FGF2, MYLK, ITGA3, ITGA5, ITGB1, ITGB5, ITGAV, FN1, ITGB3, RDX, ACTN1, ACTN4, CFL2, PPP1R12A, MSN, RRAS, ARHGEF4, GNA13, ITGA1",0.0958256317158365,0.0287241512618947,FALSE +"A549","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.40139,-1.15,0.26,6945,0.716,"ATG7, PIK3R4, BECN1, PRKAA1, ATG4A, PIK3C3, GABARAPL1, GABARAPL2",0.585026652029182,0.145086977692144,FALSE +"A549","Input","KEGG_RENAL_CELL_CARCINOMA",-0.34015,-0.982,0.413,7111,0.74,"HGF, SOS1, MAP2K1, PIK3CD, RAP1B, RAPGEF1, MAP2K2, BRAF, RAC1, PAK2, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PAK3, CRKL, PAK1, PIK3CB, FLCN, AKT1, MAPK1, MAPK3, PAK5, PAK6",0.384049948343599,0.130768280269024,FALSE +"A549","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.32666,0.963,0.431,717,0.723,"ENPEP, NLN",0.365522729839268,0.140861702705469,FALSE +"A549","Input","KEGG_RETINOL_METABOLISM",0.37317,1.07,0.328,1303,0.605,"ALDH1A1, ALDH1A2, DHRS3, RETSAT, RDH10",0.484126156288321,0.218244625347531,FALSE +"A549","Input","KEGG_RIBOFLAVIN_METABOLISM",0.4058,1.18,0.221,1653,0.604,"RFK, ENPP1",0.655607726314889,0.218963061378868,FALSE +"A549","Input","KEGG_RIBOSOME",0.57171,1.7,0.0498,3500,0.358,"RPS4Y1, RPL22L1, RPL35, RPL36, RPS6, RPL32, RPL18, RPLP2, RPL24, RSL24D1, RPS24, RPL28, RPS8, RPS12, RPL7A, RPL26, RPL18A, RPL13A, RPSA, RPL17, RPL36A, RPL36AL, RPL35A, RPL6, RPL23A, RPL9, RPL27A, RPL31, RPL21, RPL23, RPL22, RPS3A, RPS26, RPL12, RPL34, RPL37A, RPS28, RPL10A, RPL4, RPL3, RPS2, RPL7, FAU, RPL29, RPS18, RPL27, RPS4X, RPS29, RPL5, RPL11, RPS15A, RPL14, RPL30, MRPL13, RPL13, RPL8, RPS9, RPS15, RPS3, RPS17, RPLP0, RPS23",1.30277065724028,0.446116973356126,FALSE +"A549","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.34822,-0.99,0.438,8229,0.734,"MAPK14, NFKBIA, FADD, SIKE1, NFKB1, IFIH1, DDX58, DHX58, ISG15, MAPK12",0.3585258894959,0.134303940083929,FALSE +"A549","Input","KEGG_RNA_DEGRADATION",0.36616,1.07,0.319,2448,0.605,"TENT4A, PARN, ZCCHC7, MPHOSPH6, TTC37, EXOSC1, C1D, ENO3, SKIV2L, XRN2, EXOSC8, PAPOLG, EXOSC5, EXOSC10, MTREX, EXOSC9, EXOSC4, EXOSC3, DCP1B, EXOSC7, EXOSC6",0.496209316942819,0.218244625347531,FALSE +"A549","Input","KEGG_RNA_POLYMERASE",0.51095,1.53,0.0747,4124,0.43,"POLR2D, POLR1E, POLR2L, POLR3H, POLR2I, POLR3D, POLR2E, POLR2G, POLR3A, POLR3C, POLR3G, POLR1A, POLR3GL, POLR3F, POLR3K, POLR3B",1.1266793981846,0.366531544420413,FALSE +"A549","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.27573,0.813,0.677,1692,0.852,"GGT1, PAPSS2, MAT2A, MAT1A, GGT5",0.169411331314856,0.0695604052332999,FALSE +"A549","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.35319,1.02,0.376,376,0.67,"COL4A1, COL4A2, ITGA3, ITGB1, AKT3, LAMB1, ITGAV, FN1",0.424812155072339,0.173925197299174,FALSE +"A549","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.29286,-0.834,0.626,7613,0.808,"STX6, STX18, SNAP23, STX16, SEC22B, SNAP47, STX12, STX7, SNAP29, VAMP4, YKT6, VAMP8, STX3, VAMP5",0.20342566678957,0.0925886392254138,FALSE +"A549","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.29964,-0.851,0.608,9645,0.81,"SMPD3, UGT8",0.216096420727265,0.0915149811213502,FALSE +"A549","Input","KEGG_SPLICEOSOME",0.21371,0.634,0.955,6295,0.969,"HSPA2, HSPA1L, DDX42, TRA2A, SNRPD3, SNRPB, U2AF1, DDX46, SRSF9, DDX23, SNRPG, PUF60, SF3B5, U2AF2, SNU13, THOC1, DDX5, SNRPF, HNRNPA1, RBMX, SRSF7, THOC3, SNRNP70, SF3A1, HNRNPC, SNRPC, SF3B6, SF3A2, SRSF2, SNRPA, SMNDC1, SNRPD1, SNRPD2, SF3A3, THOC2, CHERP, SF3B1, PRPF8, SRSF3, SRSF8, EFTUD2, DDX39B, HSPA6, HNRNPA3, SRSF1, TCERG1, LSM2, PHF5A, TRA2B, NCBP2, PPIL1, SNRPE, NCBP1, SNW1, SRSF4, PRPF3, HSPA8, ALYREF, SNRNP40, SRSF10, USP39, HNRNPK, RBM22, RBM17, PRPF40A, SF3B4, CDC5L, SNRNP200, RBM25, PLRG1, PRPF19, HSPA1A, DHX38, PQBP1, SF3B2, PRPF31, CRNKL1, CTNNBL1, HNRNPM, TXNL4A, PRPF4, RBM8A, ZMAT2, U2SURP, SNRPA1, ACIN1, SF3B3, BCAS2, LSM4, XAB2, DHX8, AQR, SNRPB2, CCDC12, WBP11, PRPF40B, SRSF5, EIF4A3, LSM3, SART1, SLU7, LSM7, ISY1, LSM8, PCBP1, PRPF38B, DHX15, SRSF6, DHX16, PRPF6, SYF2, PPIH, LSM6",0.0199966284162537,0.0136762229492347,FALSE +"A549","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.40793,-1.19,0.228,8377,0.739,"PGM1, GYS1, UGT2B17, AGL, HK2, GCK, PGM2, HK1",0.642065152999546,0.131355561605174,FALSE +"A549","Input","KEGG_STEROID_BIOSYNTHESIS",-0.72831,-2.11,0.00358,8256,0.226,"HSD17B7, CEL, LIPA, MSMO1, SOAT2, DHCR7, FDFT1, CYP27B1, SC5D, DHCR24",2.44611697335613,0.645891560852599,TRUE +"A549","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.37622,-1.08,0.315,9676,0.731,"HSD11B2, SULT1E1, HSD17B2",0.501689446210399,0.13608262304214,FALSE +"A549","Input","KEGG_SULFUR_METABOLISM",-0.6033,-1.75,0.0237,9422,0.513,"BPNT1, SULT1E1",1.6252516539899,0.289882634888184,FALSE +"A549","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.72897,2.18,0.00685,1814,0.199,"C1S, C9, ACTN1, ACTN4, C1R, CD40, C4A, SNRPD3, SNRPB",2.16430942850757,0.701146923590293,TRUE +"A549","Input","KEGG_TASTE_TRANSDUCTION",-0.433,-1.25,0.182,9776,0.707,"SCNN1A",0.739928612014925,0.150580586203101,FALSE +"A549","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.72157,-2.03,0.0107,8203,0.243,"MVK, GGPS1, PMVK, IDI1, ACAT2, MVD, HMGCR, FDPS, HMGCS2",1.97061622231479,0.614393726401688,TRUE +"A549","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.29945,0.888,0.56,1868,0.805,"TGFB2, TGFBR2, TGFBR1, ACVR1, SMAD3, SMAD2, ID1, ZFYVE16, SMURF2, ROCK2, INHBA",0.2518119729938,0.0942041196321315,FALSE +"A549","Input","KEGG_THYROID_CANCER",-0.50713,-1.45,0.104,6880,0.682,"TCF7L2, MAP2K1, CCDC6, RXRA, RXRB, MAP2K2, BRAF, CTNNB1, NCOA4, KRAS, NRAS, CDH1, MAPK1, MAPK3",0.98296666070122,0.166215625343521,FALSE +"A549","Input","KEGG_TIGHT_JUNCTION",-0.403,-1.15,0.263,8041,0.716,"KRAS, NRAS, OCLN, PRKCI, PARD6A, AFDN, F11R, CTNNA1, PRKCD, TJAP1, PPP2R1B, AKT1, MYH7, EPB41, PATJ, ACTG1, PRKCZ, EPB41L3, MYH14, MYH7B, HCLS1, TJP3, CRB3, CGN, CLDN11, TJP2, CLDN3, CLDN7, CLDN4, CLDN18",0.580044251510242,0.145086977692144,FALSE +"A549","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.44005,-1.23,0.224,7315,0.708,"PIK3CD, TLR2, RIPK1, MYD88, MAP2K3, MAPK10, IL6, MAP2K2, RAC1, MAP3K7, PIK3R1, PIK3CA, MAPK14, IFNAR1, NFKBIA, IRAK4, FADD, PIK3CB, CTSK, NFKB1, AKT1, MAPK1, MAP2K7, MAPK3, FOS, TLR3, MAPK12",0.649751981665837,0.149966742310231,FALSE +"A549","Input","KEGG_TRYPTOPHAN_METABOLISM",0.31298,0.922,0.502,316,0.78,"KYNU, ALDH2, ALDH1B1",0.299296282854981,0.10790539730952,FALSE +"A549","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.29933,-0.877,0.585,7090,0.768,"MAPK9, PDX1, PIK3CD, MAPK10, PIK3R1, PIK3CA, PRKCD, PIK3CB, MAPK1, HK2, GCK, PRKCZ, MAPK3, HK1",0.23284413391782,0.114638779968488,FALSE +"A549","Input","KEGG_TYROSINE_METABOLISM",-0.47428,-1.41,0.111,8581,0.557,"LCMT1, MAOB, IL4I1, MIF, ALDH1A3, MAOA, ADH4, ADH7, ADH1C",0.954677021213343,0.254144804826271,FALSE +"A549","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.51039,-1.46,0.0882,7558,0.76,"NFKBIE, MAP2K2, PAK2, VAV2, GSK3B, RAF1, MAP3K7, PIK3R1, DLG1, KRAS, NRAS, VAV1, PTPRC, PIK3CA, PAK3, MAPK14, NCK2, CBLB, PTPN6, BCL10, NFKBIA, VAV3, PAK1, PIK3CB, NFKB1, AKT1, MAPK1, MAP2K7, MAPK3, PDPK1, CBL, FOS, LCK, PAK5, PAK6, CARD11, NFATC2, MAPK12",1.05453141486818,0.119186407719209,FALSE +"A549","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.21024,-0.609,0.964,7832,0.99,"UBE2Q1, UBE2NL, UBE3A, UBE2L3, UBE4A, CUL7, UBE2D4, FBXO2, UBE2B, CBLB, PML, UBE2K, WWP2, FZR1, UBA6, UBE2C, CBL, RCHY1, UBE2L6, KEAP1, UBA7",0.0159229660971692,0.00436480540245009,FALSE +"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.30756,0.915,0.546,6795,0.762,"BCAT2, PDHA1, PDHB, IARS2, BCAT1, VARS2, LARS2",0.262807357295263,0.1180450286604,FALSE +"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.37201,-1.07,0.337,6530,0.697,"EHHADH, BCAT1, BCKDHB, HMGCL, HADH, HADHA, PCCB, HMGCS1, DLD, MCCC2, PCCA, ALDH6A1, DBT, ALDH9A1, ACAD8, ACADM, ACAT2, IL4I1, IVD, MCCC1, ABAT, HMGCS2, OXCT1",0.472370099128661,0.156767221901991,FALSE +"A549","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.47889,1.42,0.0958,1975,0.496,"PPP1R14A, CALD1, MYLK, PLCB4, KCNMA1, PRKCG, PLA2G4A, ITPR1, PPP1R12A, PRKCB, PRKCH, PPP1R12B, ADCY3, ADCY8, GNA13, PRKCQ, PRKCE, NPR2, MYL6, GNAQ, PRKACA, PRKCA, MYL6B, MYH11, ACTA2, ARHGEF1, ROCK2, MYL9, GNA12, PPP1CB",1.01863449092146,0.304518323509803,FALSE +"A549","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.17061,-0.499,0.995,7555,1,"AQP3, ARHGDIA, CREB3L2, AVP, RAB11B, ARHGDIB",0.00217691925427455,0,FALSE +"A549","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.3919,-1.11,0.265,7636,0.693,"MAP2K2, RAC1, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, MAPK14, PLCG2, SPHK1, MAPKAPK2, PIK3CB, AKT1, MAPK1, MAPKAPK3, PLA2G12A, MAPK3, NFATC2, PLA2G2A, MAPK12, RAC2",0.576754126063192,0.159266765388193,FALSE +"A549","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.33882,-0.947,0.475,8257,0.75,"PLCG2, ATP6AP1, ATP6V1C1, ATP6V1E1, ATP6V1B2, ATP6V1F, ERO1A, ATP6V1A, ATP6V1H, ATP6V1D, ACTG1, ATP6V1B1, ATP6V1G1, TJP2",0.323306390375133,0.1249387366083,FALSE +"A549","Input","KEGG_VIRAL_MYOCARDITIS",-0.39183,-1.14,0.254,8578,0.687,"ICAM1, CASP3, MYH7, ACTG1, MYH14, MYH7B, ITGAL, RAC2",0.595166283380062,0.16304326294045,FALSE +"A549","Input","KEGG_WNT_SIGNALING_PATHWAY",0.21665,0.655,0.956,1261,0.978,"FZD2, PLCB4, PRKCG, DKK1, NKD2, LRP6, MMP7, PRKCB, FZD7, SMAD3, PPP3R1, SMAD2, PRKACA, PRKCA",0.0195421077238999,0.00966114521239857,FALSE +"HCC15","Input","KEGG_ABC_TRANSPORTERS",0.70761,2.25,0.00644,705,0.102,"ABCC2, ABCC3, ABCG2, ABCD1, ABCA3, ABCC1, ABCA13, TAP2, ABCB6",2.19111413264019,0.991399828238082,TRUE +"HCC15","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.34599,-1.06,0.35,7526,0.95,"NFKB1, CCND1, PIK3CD, PIK3CB, SOS1, RUNX1, TCF7L1, RAF1, PIK3R2, RUNX1T1, CEBPA, AKT3, PIK3CG, GRB2, SPI1, EIF4EBP1",0.455931955649724,0.0222763947111523,FALSE +"HCC15","Input","KEGG_ADHERENS_JUNCTION",0.32027,1,0.382,926,0.57,"TJP1, PTPRJ, TGFBR2, EGFR, PTPRB, ACTN4, CDH1, IQGAP1, CTNNB1, CTNND1, CTNNA2, CTNNA1, PTPN1, NECTIN2",0.417936637088291,0.244125144327509,FALSE +"HCC15","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.48884,1.51,0.0788,2462,0.295,"SLC2A1, ACSL3, LEPR, IRS1, PRKAG1, AKT1, ACACB, CHUK, PRKAA1, MAPK8, ACSL1, STK11, PRKAG2, ADIPOR1, MAPK9, PRKAB1, CPT1A, NFKBIB, AKT2, MAPK10, TRAF2, TNFRSF1A, ACSL6",1.10347378251044,0.530177984021837,FALSE +"HCC15","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.39279,1.23,0.203,1685,0.41,"ASS1, CPS1, GPT, GLUD1, GOT1, ALDH4A1, GFPT1, PPAT, ALDH5A1, GOT2",0.692503962086787,0.387216143280265,FALSE +"HCC15","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.3622,1.16,0.241,478,0.456,"ATP1B1, PIK3R3, SLC9A3R2, IRS1, SFN",0.617982957425132,0.341035157335565,FALSE +"HCC15","Input","KEGG_ALZHEIMERS_DISEASE",-0.20356,-0.641,0.927,8137,1,"IL1B, UQCRC2, NDUFS4, UQCR10, APP, GSK3B, PLCB2, LRP1, GRIN1, UQCRB, APOE, MME, UQCRFS1, UQCRQ, ATP2A3, LPL, ATP2A1, SNCA",0.0329202658555029,0,FALSE +"HCC15","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.376,1.18,0.244,2253,0.438,"IARS2, RARS2, SARS2, MARS2, YARS2, NARS2, MTFMT, EARS2, DARS2, FARSB",0.612610173661271,0.3585258894959,FALSE +"HCC15","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.30031,0.939,0.472,1513,0.602,"UGDH, GNPNAT1, HEXA, PGM3, GNPDA2, PMM2, GALE, GFPT1",0.326058001365912,0.220403508742175,FALSE +"HCC15","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.343,1.06,0.346,2652,0.515,"MAPK13, BCL2L1, APAF1, MAP2K6, RAB5A, TP53, DERL1, PRPH, PRPH2, PPP3CC, TNFRSF1A, CASP1, TOMM40, BAD, CAT",0.460923901207223,0.288192770958809,FALSE +"HCC15","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.3367,1.04,0.378,1309,0.533,"B2M, HSPA1L, HSPA2, CTSL, TAP2, LGMN, HSPA6, TAPBP, PSME2, HSPA1A",0.422508200162775,0.273272790973428,FALSE +"HCC15","Input","KEGG_APOPTOSIS",0.29657,0.934,0.474,1161,0.604,"IL1A, TNFRSF10A, BCL2L1, CAPN2, PIK3R3, CAPN1, AKT1, ENDOD1, CHUK, ATM, BIRC2, APAF1, CASP7",0.324221658325915,0.218963061378868,FALSE +"HCC15","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.57412,1.8,0.0224,746,0.289,"AKR1C3, GGT1, LTA4H, PTGES, CBR3, CBR1, PTGS2",1.64975198166584,0.539102157243452,FALSE +"HCC15","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.27417,0.882,0.58,1685,0.667,"ASS1, ODC1, ALDH2, CPS1, MAOA, ALDH3A2, ALDH7A1, GLUD1, GAMT, GOT1, ALDH4A1, ALDH9A1, SAT2, GOT2",0.236572006437063,0.175874166083451,FALSE +"HCC15","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.45423,1.45,0.0876,897,0.286,"ITGA1, PKP2, ITGB5, ACTN4, ITGB4, DMD, CDH2, ITGA6, ITGA3, ITGA2, CTNNB1, DES, CTNNA2, CACNA1C, CTNNA1, LMNA",1.05749589383192,0.543633966870957,FALSE +"HCC15","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.7467,2.33,0,1421,0.0792,"ALDH2, UGDH, ALDH3A2, ALDH7A1, ALDH9A1",Inf,1.10127481841051,TRUE +"HCC15","Input","KEGG_AXON_GUIDANCE",-0.25068,-0.759,0.722,7564,1,"RGS3, ROCK1, RHOA, PLXNB1, NFATC4, EPHA1, NCK2, PAK3, PAK1, NFATC1, SEMA4A, GSK3B, RAC2, DPYSL5, L1CAM, NFATC2, ROBO1, FES, NTNG1, NCK1, RAC3, NTN4, UNC5B, SEMA7A, PLXNA1",0.141462802430361,0,FALSE +"HCC15","Input","KEGG_BASAL_CELL_CARCINOMA",0.27273,0.849,0.613,2498,0.696,"FZD6, CTNNB1, APC, TP53, SMO, DVL2, AXIN1, STK36, BMP4",0.212539525481585,0.157390760389438,FALSE +"HCC15","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.36818,-1.12,0.294,6612,0.951,"TAF1, TAF9B, TAF10, TAF5, TAF6, GTF2F1, TAF9, TAF4, GTF2B, GTF2E1, GTF2E2, TAF12, GTF2F2, TAF7",0.531652669587843,0.0218194830625861,FALSE +"HCC15","Input","KEGG_BASE_EXCISION_REPAIR",-0.28007,-0.869,0.582,7320,0.914,"APEX1, MBD4, PARP1, POLB, SMUG1, TDG, MPG, NEIL2",0.235077015350112,0.0390538042661686,FALSE +"HCC15","Input","KEGG_BETA_ALANINE_METABOLISM",0.41599,1.3,0.164,1421,0.378,"ALDH2, ALDH3A2, ALDH7A1, ECHS1, EHHADH, ALDH9A1",0.785156151952302,0.422508200162775,FALSE +"HCC15","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.40036,-1.24,0.191,8886,0.77,"SCD, FADS2, ELOVL6, SCD5",0.718966632752272,0.113509274827518,FALSE +"HCC15","Input","KEGG_BLADDER_CANCER",-0.32802,-1.01,0.391,8344,0.947,"E2F3, RAF1, CDK4, MDM2, MMP2, VEGFA, RB1, CDKN2A",0.407823242604133,0.0236500209967266,FALSE +"HCC15","Input","KEGG_BUTANOATE_METABOLISM",0.32717,1.02,0.381,1602,0.55,"ALDH2, AACS, ACADS, ALDH3A2, ALDH7A1, ECHS1, EHHADH, ALDH9A1, ALDH5A1",0.419075024324381,0.259637310505756,FALSE +"HCC15","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.39899,-1.22,0.236,8272,0.774,"NFATC1, GSK3B, CD81, PLCG2, RAF1, BTK, RAC2, PIK3R2, PRKCB, AKT3, VAV3, NFATC2, CD79A, PIK3CG, GRB2, RAC3, PIK3AP1, FCGR2B, INPP5D, CD79B",0.627087997029893,0.111259039317107,FALSE +"HCC15","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.336,-1.04,0.357,8465,0.932,"PLCG1, PLCG2, TNNC1, PLCB2, PRKCB, RYR1, GRIN1, MYLK, PDGFRB, PDE1C, ATP2A3, PLCZ1, ATP2A1, CAMK4, BST1, SLC8A1",0.447331783887807,0.0305840876460186,FALSE +"HCC15","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.4178,-1.28,0.184,8212,0.964,"UQCRC2, CACNB3, UQCR10, ATP1B3, TNNC1, UQCRB, UQCRFS1, UQCRQ, TPM2, CACNA2D1, SLC8A1",0.735182176990464,0.0159229660971692,FALSE +"HCC15","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.39663,1.22,0.212,926,0.416,"CLDN6, ICAM2, CD274, CADM1, CD40, OCLN, CDH1, CD99, CDH2, SDC4, CDH4, ITGA6, NEGR1, ICAM1, CLDN1, MPZ, MPZL1, NECTIN2",0.673664139071249,0.380906669373257,FALSE +"HCC15","Input","KEGG_CELL_CYCLE",-0.27195,-0.827,0.641,7699,0.929,"PTTG1, CDKN1A, CDC20, CDKN1B, CREBBP, TFDP2, DBF4, GSK3B, E2F3, CHEK2, ZBTB17, E2F4, BUB1, CCND2, ORC6, CDK4, MDM2, SKP2, SMAD4, E2F5, TFDP1, RB1, EP300, CDKN2A",0.193141970481183,0.0319842860063582,FALSE +"HCC15","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.17974,0.578,0.977,1425,0.972,"CXCL8, ARRB1, PIK3R3, STAT1, GNAI1, ADCY9, AKT1, ADCY5, ROCK2, GNG2, CCL13, RASGRP2, CHUK, GNG12, ADCY6, VAV2, SHC1",0.0101054362812269,0.0123337350737254,FALSE +"HCC15","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.33954,-1.04,0.353,7526,0.932,"NFKB1, BCR, CCND1, PIK3CD, PIK3CB, CDKN1A, CTBP1, CDKN1B, SOS1, MECOM, RUNX1, E2F3, RAF1, PIK3R2, CDK4, MDM2, AKT3, SMAD4, PIK3CG, CBLB, GRB2, RB1, CDKN2A",0.452225294612177,0.0305840876460186,FALSE +"HCC15","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.46598,1.49,0.0792,1738,0.295,"PC, IDH3G, OGDH, OGDHL, DLAT, CS, IDH3B, FH, IDH3A, SDHC",1.10127481841051,0.530177984021837,FALSE +"HCC15","Input","KEGG_COLORECTAL_CANCER",-0.19612,-0.597,0.96,6493,1,"TGFB1, CASP3, TGFB2, CYCS, MAPK1, BRAF, PIK3R1, FOS, APPL1, CCND1, PIK3CD, PIK3CB, RHOA, BIRC5, GSK3B, TCF7L1, RAF1, RAC2, PIK3R2, AKT3, SMAD4, PIK3CG, RAC3",0.0177287669604316,0,FALSE +"HCC15","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.41377,1.29,0.185,1274,0.367,"THBD, PLAUR, MBL2, F2R, C9, PLAU, CFH, SERPINA1, PROC, CD46, CD59, TFPI",0.732828271596986,0.435333935747911,FALSE +"HCC15","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.29763,0.941,0.489,1685,0.606,"MAT1A, CBS, APIP, GOT1, SDS, LDHA, GOT2",0.31069114087638,0.217527375833714,FALSE +"HCC15","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.47072,1.46,0.0985,890,0.292,"IL1A, TNFRSF12A, TNFRSF19, TNFRSF21, IFNGR1, IL18, TNFRSF10A, CXCL8, TGFBR2, EGFR, CD40, KIT, LEPR, BMPR1A, IL13RA1, BMPR2, OSMR, CCL13",1.00656376950239,0.534617148551582,FALSE +"HCC15","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.34526,1.09,0.307,1168,0.505,"ZBP1, IL18, DDX58, CHUK, RIPK3, PYCARD",0.512861624522813,0.296708621881339,FALSE +"HCC15","Input","KEGG_DILATED_CARDIOMYOPATHY",0.34044,1.08,0.337,897,0.491,"ITGA1, ITGB5, ITGB4, DMD, ITGA6, ITGA3, ITGA2, ADCY9, DES, ADCY5, CACNA1C, LMNA",0.472370099128661,0.308918507877032,FALSE +"HCC15","Input","KEGG_DNA_REPLICATION",0.3924,1.25,0.188,3223,0.392,"POLD1, LIG1, MCM6, MCM5, MCM3, MCM7, RFC1, POLA1, MCM4, POLE4, POLD3, POLE2, FEN1, POLA2, SSBP1, POLE, PRIM1, MCM2, PRIM2",0.72584215073632,0.406713932979543,FALSE +"HCC15","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.33996,1.08,0.29,201,0.491,"PIWIL1, EGFR",0.537602002101044,0.308918507877032,FALSE +"HCC15","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.55855,1.74,0.0335,1069,0.221,"ALDH3A1, GSTM4, GSTM3, GSTM2, CYP3A7, MAOA, ALDH3B1, MGST1",1.47495519296315,0.655607726314889,TRUE +"HCC15","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.49619,1.54,0.0781,360,0.309,"CES1, CES2, CDA, UPP1, CYP3A7",1.1073489661227,0.510041520575165,FALSE +"HCC15","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.4732,-1.48,0.0763,8261,0.985,"LAMC1, COL6A2, ITGA5, HSPG2, COL2A1, ITGA4, TNXB, COL6A3, TNC, COL3A1, CD47, VTN, FN1, COL6A1, COL5A1, SDC2, COL1A1, ITGB3, THBS3, LAMB1, ITGA7, SV2A, COL4A2, SDC1, COL1A2, ITGB8",1.11747546204512,0.00656376950238827,FALSE +"HCC15","Input","KEGG_ENDOCYTOSIS",0.34167,1.1,0.291,2148,0.497,"DNM3, EGFR, SMURF1, KIT, HSPA1L, EHD4, ARRB1, SMURF2, HSPA2, F2R, RAB11FIP5, ERBB4, DNM1, RAB11A, WWP1, AP2S1, RAB11FIP2, HSPA6, EHD1, AP2A2, ASAP2, EHD2, RAB5C, NEDD4, PLD2, RAB5A, AP2M1, HSPA1A, RAB31, IQSEC2, CLTC, AP2B1, CLTB, IGF1R, ARF6, EEA1, ITCH, PIP5K1A, HRAS, MVB12B, AP2A1, CHMP2A, EHD3, DAB2, RAB5B, SH3GLB2, USP8",0.536107011014093,0.303643611266668,FALSE +"HCC15","Input","KEGG_ENDOMETRIAL_CANCER",0.23855,0.744,0.781,813,0.822,"EGFR, CDH1, PIK3R3, CTNNB1, AKT1, CTNNA2, CTNNA1",0.1073489661227,0.0851281824599496,FALSE +"HCC15","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.37547,1.18,0.234,1160,0.438,"MAPK13, TJP1, CXCL8, EGFR, TCIRG1, ATP6V0D1, ATP6V0A1, CHUK, MAPK8, ATP6V0A2, JUN",0.630784142589857,0.3585258894959,FALSE +"HCC15","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.264,-0.82,0.682,7470,0.925,"MAP2K7, PIK3CD, PIK3CB, CDKN1A, CDKN1B, SOS1, NCK2, PAK3, PAK1, GAB1, GSK3B, PLCG1, PLCG2, RAF1, PIK3R2, PRKCB, AKT3, PIK3CG, NCK1, CBLB, GRB2, EIF4EBP1",0.166215625343521,0.0338582672609674,FALSE +"HCC15","Input","KEGG_ETHER_LIPID_METABOLISM",0.56003,1.79,0.031,1505,0.274,"PLPP2, PLPP3, AGPS, LPCAT1, PLD2, PAFAH1B1",1.50863830616573,0.562249437179612,FALSE +"HCC15","Input","KEGG_FATTY_ACID_METABOLISM",0.49015,1.53,0.0907,1022,0.297,"ALDH2, ECI1, ACSL3, ACADS, ACADSB, ALDH3A2, ALDH7A1, HADHB, ECHS1, EHHADH, ACSL1",1.0423927129399,0.527243550682788,FALSE +"HCC15","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.34917,-1.07,0.338,7470,1,"MAP2K7, MAP2K3, PRKCE, PIK3CD, PIK3CB, PDPK1, SOS1, LCP2, PLCG1, PLCG2, RAF1, BTK, RAC2, PIK3R2, PLA2G12A, PRKCB, AKT3, VAV3, PIK3CG, PRKCD, GRB2, RAC3, INPP5D",0.471083299722345,0,FALSE +"HCC15","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.30888,-0.943,0.472,8465,0.948,"PLCG1, PLCG2, RAF1, RAC2, GSN, PIK3R2, PRKCB, AKT3, WASF1, VAV3, DOCK2, PIK3CG, PRKCD, PTPRC, FCGR2B, FCGR2C, INPP5D, MARCKSL1, WASF3",0.326058001365912,0.0231916626619338,FALSE +"HCC15","Input","KEGG_FOCAL_ADHESION",-0.29831,-0.909,0.544,7572,0.956,"CCND1, PIK3CD, COL11A1, ROCK1, PIK3CB, RHOA, PDPK1, THBS1, LAMB2, TLN1, HGF, SOS1, ACTN3, PAK3, PAK1, LAMC1, GSK3B, COL6A2, ITGA5, COL2A1, RAF1, ITGA4, TNXB, CCND2, RAC2, COL6A3, PIK3R2, TNC, PRKCB, COL3A1, MYLK, PDGFRB, AKT3, VTN, FN1, VAV3, PIK3CG, COL6A1, ACTG1, COL5A1, GRB2, COL1A1, RAC3, VEGFA, ITGB3, THBS3, LAMB1, ITGA7, COL4A2, COL1A2, ITGB8",0.26440110030182,0.0195421077238999,FALSE +"HCC15","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.40989,-1.27,0.184,7440,0.918,"FPGS, DHFR, ALPG, GCH1, ALPI, ALPP",0.735182176990464,0.0371573187987575,FALSE +"HCC15","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.31955,-0.971,0.415,8060,0.929,"MPI, PFKFB4, ALDOB, HK2, FBP1, FBP2, ALDOC",0.381951903287907,0.0319842860063582,FALSE +"HCC15","Input","KEGG_GALACTOSE_METABOLISM",0.30693,0.974,0.444,278,0.586,"PFKP, GLA",0.35261702988538,0.232102383981909,FALSE +"HCC15","Input","KEGG_GAP_JUNCTION",0.30337,0.952,0.479,711,0.603,"TJP1, TUBB2B, ITPR3, EGFR, GNAI1, ADCY9, ADCY5",0.319664486585437,0.219682687859849,FALSE +"HCC15","Input","KEGG_GLIOMA",-0.41747,-1.3,0.188,7572,1,"CCND1, PIK3CD, PIK3CB, CDKN1A, SOS1, E2F3, PLCG1, PLCG2, RAF1, PIK3R2, PRKCB, CDK4, PDGFRB, MDM2, AKT3, PIK3CG, GRB2, RB1, CDKN2A",0.72584215073632,0,FALSE +"HCC15","Input","KEGG_GLUTATHIONE_METABOLISM",0.4926,1.51,0.0977,505,0.295,"GCLC, GGT1, GSTM4, GSTM3, ODC1, GSTM2, GCLM, GSR, G6PD",1.01010543628123,0.530177984021837,FALSE +"HCC15","Input","KEGG_GLYCEROLIPID_METABOLISM",0.43127,1.35,0.147,961,0.35,"PLPP2, GLA, ALDH2, AGPAT3, CEL, PLPP3, GPAT3, ALDH3A2, ALDH7A1, DGKE",0.832682665251824,0.455931955649724,FALSE +"HCC15","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33289,1.04,0.35,1184,0.533,"PLPP2, MBOAT7, AGPAT3, PLPP3, GPAT3, GPD2, PTDSS2, DGKE, LPCAT1, PLD2, GNPAT",0.455931955649724,0.273272790973428,FALSE +"HCC15","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.54594,1.72,0.0503,1176,0.226,"ALAS1, GLDC, CBS, MAOA, SHMT1, GAMT, PHGDH, SDS",1.29843201494407,0.645891560852599,FALSE +"HCC15","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.35208,1.12,0.276,1802,0.474,"ALDH3A1, PFKP, ALDH2, ALDH3A2, ALDH3B1, ALDH7A1, DLAT, LDHA, ACSS2, ALDH9A1, PKLR, GALM, ENO3",0.559090917934782,0.324221658325915,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.47352,-1.47,0.101,6273,0.877,"CHPF, CHST14, B3GALT6, CHSY1, UST, CHPF2, B3GAT3, DSE",0.995678626217357,0.0570004066339595,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.31687,0.998,0.423,134,0.566,"GLCE",0.373659632624958,0.247183568811729,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.28245,0.889,0.543,1373,0.662,"ST3GAL1, B4GAT1",0.265200170411153,0.1791420105603,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.37857,1.19,0.211,2467,0.447,"HEXA, GUSB, GALNS, NAGLU, GNS, IDUA, HGSNAT",0.675717544702307,0.349692476868064,FALSE +"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.55602,1.75,0.0333,871,0.254,"ST3GAL5, HEXA, ST3GAL1",1.47755576649368,0.595166283380062,FALSE +"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.64249,2.04,0.0126,871,0.17,"GLA, HEXA, ST3GAL1",1.89962945488244,0.769551078621726,TRUE +"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.36335,1.14,0.248,1373,0.469,"ST3GAL4, B4GAT1",0.605548319173784,0.328827157284917,FALSE +"HCC15","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.27826,-0.858,0.636,7454,0.92,"GPAA1, PIGN, PIGO, PGAP1, PIGU",0.196542884351586,0.0362121726544447,FALSE +"HCC15","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.26821,0.846,0.586,1213,0.681,"HYI, CS",0.232102383981909,0.166852888087215,FALSE +"HCC15","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.28335,0.877,0.54,1334,0.669,"MAPK13, ITPR3, EGFR, ADCY9, ADCY5, CACNA1C, MAPK8, JUN, PLD2, MAP2K6, ITPR2, ADCY6",0.267606240177031,0.174573882232177,FALSE +"HCC15","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.20457,0.644,0.919,2498,0.937,"CSNK1G2, CSNK1G3, SMO, PRKACB, RAB23, CSNK1A1, STK36, BMP4",0.0366844886138887,0.0282604091122217,FALSE +"HCC15","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.40366,1.25,0.192,684,0.392,"ITGA1, IL1A, KIT, CD14, ITGA6, ITGA3, ITGA2, CD9",0.71669877129645,0.406713932979543,FALSE +"HCC15","Input","KEGG_HISTIDINE_METABOLISM",0.5574,1.77,0.0397,829,0.253,"ALDH3A1, AMDHD1, ALDH2, MAOA, ALDH3A2, ALDH3B1, ALDH7A1",1.40120949323689,0.596879478824182,FALSE +"HCC15","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.22548,-0.709,0.853,6332,1,"RAD54L, TOP3B, BRCA2, RAD51, POLD4, RAD51B, XRCC3, SEM1, RAD52, RAD54B",0.069050968832477,0,FALSE +"HCC15","Input","KEGG_HUNTINGTONS_DISEASE",-0.19488,-0.614,0.955,6353,1,"POLR2D, ATP5PO, CREB5, COX5B, ATP5F1E, GPX1, CASP3, HDAC1, CYCS, ATP5PD, NDUFV2, IFT57, POLR2E, NDUFA7, DLG4, COX7A2L, NDUFAB1, PLCB1, NDUFS6, COX6C, POLR2L, HDAC2, NDUFA6, NDUFS5, HAP1, POLR2C, CREB1, DNAL4, POLR2G, NRF1, TAF4, POLR2J, CREBBP, PPID, UQCRC2, NDUFS4, UQCR10, POLR2I, POLR2K, SP1, POLR2H, PLCB2, GRIN1, UQCRB, UQCRFS1, UQCRQ, POLR2F, DNAH3, REST, EP300",0.0199966284162537,0,FALSE +"HCC15","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.31101,0.955,0.462,1010,0.605,"ITGA1, ITGB5, ITGB4, DMD, ITGA6, ITGA3, ITGA2, PRKAG1, DES, CACNA1C, LMNA, PRKAA1",0.335358024443874,0.218244625347531,FALSE +"HCC15","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.33281,-1.06,0.334,7590,0.95,"PIK3CD, PI4KB, PIK3CB, INPP5B, PLCG1, PLCG2, PIP4K2A, IMPA2, PLCB2, INPP4B, PIK3CG, ALDH6A1, PLCZ1",0.476253533188435,0.0222763947111523,FALSE +"HCC15","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.19482,-0.613,0.948,7590,1,"PIK3CD, PIK3CB, PDPK1, INSR, EIF4E, SOS1, FOXO1, GSK3B, HK2, FBP1, RAF1, PIK3R2, FBP2, AKT3, PIK3CG, CBLB, GRB2, PRKAR2B, INPP5D, EIF4EBP1",0.0231916626619338,0,FALSE +"HCC15","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.59889,-1.85,0.0318,8608,0.488,"ITGA4, IL6, TNFRSF13C",1.49757288001557,0.311580177997289,FALSE +"HCC15","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.26103,0.815,0.66,1056,0.729,"IFNGR1, BCL2L1, PIK3R3, LEPR, STAT1, AKT1, IL13RA1, OSMR, IRF9, SPRED1, JAK1",0.180456064458131,0.137272471682025,FALSE +"HCC15","Input","KEGG_LEISHMANIA_INFECTION",0.33992,1.08,0.317,1160,0.491,"MAPK13, IL1A, IFNGR1, STAT1, PTGS2, JAK1, JUN",0.498940737782249,0.308918507877032,FALSE +"HCC15","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.30166,0.947,0.47,885,0.604,"MAPK13, CLDN6, OCLN, ACTN4, CD99, PIK3R3, GNAI1, ICAM1, CTNNB1, CTNND1, CLDN1, ROCK2, CTNNA2, CTNNA1, RASSF5",0.327902142064283,0.218963061378868,FALSE +"HCC15","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.68417,2.21,0.00452,1421,0.105,"ALDH2, ALDH3A2, ALDH7A1, ECHS1, EHHADH, ALDH9A1",2.34486156518862,0.978810700930062,TRUE +"HCC15","Input","KEGG_LONG_TERM_DEPRESSION",-0.26318,-0.804,0.682,8559,0.941,"RAF1, GNAO1, PLCB2, PLA2G12A, PRKCB, RYR1, PRKG1",0.166215625343521,0.0264103765727431,FALSE +"HCC15","Input","KEGG_LONG_TERM_POTENTIATION",-0.27297,-0.847,0.603,8559,0.924,"RAF1, PLCB2, PRKCB, GRIN1, CAMK4, EP300",0.219682687859849,0.0343280287798933,FALSE +"HCC15","Input","KEGG_LYSINE_DEGRADATION",-0.29447,-0.924,0.517,7341,0.971,"KMT5B, SETD7, AASS, ALDH1B1, NSD1, DOT1L, NSD3, PLOD3, GCDH, SETD2, SETDB2, PLOD1, PLOD2, SETMAR, NSD2",0.286509456906058,0.0127807700919951,FALSE +"HCC15","Input","KEGG_LYSOSOME",0.42822,1.33,0.146,1901,0.357,"AGA, SLC11A2, TCIRG1, CTSV, GLA, CLN3, FUCA1, AP1S3, SLC17A5, SORT1, LIPA, ATP6V0D1, LAPTM4A, CTSL, LGMN, CTSZ, HEXA, ATP6V0A1, AP1S2, GUSB, GALNS, CD63, ATP6V0A2, PPT2, CTSF, AP1M1, CLTC, CLTB, NAGLU, IGF2R, AP4M1, NAGPA, NPC2, ABCA2, AP1G1, AP4E1, GNS, MANBA, ACP2, ATP6AP1",0.835647144215563,0.447331783887807,FALSE +"HCC15","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.24266,0.767,0.784,1309,0.791,"MAPK13, IL1A, TGFBR2, EGFR, FLNB, HSPA1L, CD14, RELB, ARRB1, HSPA2, MOS, RRAS2, NFKB2, RPS6KA5, AKT1, DDIT3, CACNA1C, PPP5C, HSPA6, RRAS, CDC25B, RASGRP2, CHUK, MAPK8, JUN, GNG12, MAP2K6, FLNC, HSPA1A",0.105683937315562,0.101823516502323,FALSE +"HCC15","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.64114,2.01,0.0134,1549,0.171,"PDX1, PKLR",1.87289520163519,0.767003889607846,TRUE +"HCC15","Input","KEGG_MELANOGENESIS",-0.28721,-0.893,0.574,8294,0.971,"GSK3B, KITLG, TCF7L1, RAF1, GNAO1, PLCB2, PRKCB, WNT10A, WNT5A, MITF, EP300",0.241088107602027,0.0127807700919951,FALSE +"HCC15","Input","KEGG_MELANOMA",-0.45576,-1.42,0.0986,7572,0.911,"CCND1, PIK3CD, PIK3CB, CDKN1A, FGFR1, HGF, E2F3, RAF1, PIK3R2, CDK4, PDGFRB, MDM2, AKT3, FGF13, FGF2, PIK3CG, MITF, FGF1, RB1, CDKN2A",1.00612308505879,0.0404816230270017,FALSE +"HCC15","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.66437,2.14,0.00823,781,0.129,"ALDH3A1, CYP2S1, AKR1C3, GSTM4, EPHX1, GSTM3, GSTM2, CYP3A7, AKR1C1, ALDH3B1",2.08460016478773,0.889410289700751,TRUE +"HCC15","Input","KEGG_MISMATCH_REPAIR",0.48924,1.53,0.0843,2364,0.297,"MSH6, MSH2, POLD1, PMS2, LIG1, MLH1, RFC1, MSH3, POLD3",1.07417242537526,0.527243550682788,FALSE +"HCC15","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.27939,-0.88,0.552,7525,0.931,"CAB39L, PIK3CD, PIK3CB, PDPK1, EIF4E, PIK3R2, AKT3, PIK3CG, VEGFA, EIF4EBP1",0.258060922270801,0.0310503190186574,FALSE +"HCC15","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.27514,0.859,0.604,710,0.693,"IFNGR1, SYK, ICAM2, TNFRSF10A, ULBP3, PIK3R3, MICB, ICAM1, RAET1L, ULBP2",0.218963061378868,0.159266765388193,FALSE +"HCC15","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.34275,1.08,0.337,1517,0.491,"LEPR, F2R, P2RX4, HCRTR1, NR3C1, TACR1",0.472370099128661,0.308918507877032,FALSE +"HCC15","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.19855,-0.61,0.955,7383,1,"YWHAB, MAP2K7, NFKB1, MAP3K5, PIK3CD, PIK3CB, RHOA, PDPK1, FOXO3, SOS1, GAB1, GSK3B, PLCG1, PLCG2, RAF1, PIK3R2, AKT3, MAGED1, PIK3CG, PRKCD, GRB2, CAMK4, ARHGDIB",0.0199966284162537,0,FALSE +"HCC15","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.52387,1.64,0.0528,1098,0.248,"NNMT, QPRT, NAMPT, NT5E, NNT, NT5C2",1.27736607746619,0.605548319173784,FALSE +"HCC15","Input","KEGG_NITROGEN_METABOLISM",-0.39534,-1.25,0.193,9360,0.793,"GLUL, CA8, CA2",0.714442690992226,0.100726812682396,FALSE +"HCC15","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.33409,1.03,0.387,1220,0.541,"MAPK13, IL18, CXCL8, CCL13, CHUK, MAPK8, BIRC2, PYCARD, CASP5",0.412289034981089,0.266802734893431,FALSE +"HCC15","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.57268,1.78,0.026,1970,0.262,"RAD50, PRKDC, NHEJ1, XRCC6, XRCC5, MRE11",1.58502665202918,0.581698708680255,FALSE +"HCC15","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.44561,-1.38,0.132,7572,0.93,"CCND1, PIK3CD, PIK3CB, PDPK1, FOXO3, SOS1, E2F3, PLCG1, PLCG2, RAF1, PIK3R2, PRKCB, CDK4, AKT3, PIK3CG, GRB2, STK4, RB1, FHIT, CDKN2A",0.87942606879415,0.0315170514460649,FALSE +"HCC15","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.39566,-1.25,0.176,6513,0.793,"HDAC1, MAML1, NUMBL, CIR1, NCSTN, RBPJ, HDAC2, SNW1, DVL3, CTBP1, NCOR2, JAG1, CREBBP, NOTCH3, DTX3, EP300",0.75448733218585,0.100726812682396,FALSE +"HCC15","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.46661,1.49,0.0956,2100,0.295,"CUL4B, DDB2, ERCC8, GTF2H3, ERCC2, GTF2H4, ERCC3, POLD1, GTF2H2, CDK7, LIG1, CCNH, DDB1, GTF2H1, RFC1, POLE4, ERCC4",1.0195421077239,0.530177984021837,FALSE +"HCC15","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.18783,-0.584,0.961,6759,1,"STT3B, B4GALT3, ALG11, FUT8, DPM3, ALG10, ALG10B, DAD1, MGAT3, MAN1A2, MAN1A1, ST6GAL1",0.0172766123314547,0,FALSE +"HCC15","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.35419,-1.09,0.308,8784,0.993,"PRKG1, PDE1C",0.511449283499556,0.00305075150461883,FALSE +"HCC15","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.26886,0.847,0.666,2649,0.692,"SHMT1, MTHFS, AMT, MTFMT, ATIC, GART",0.176525770829699,0.159893905543242,FALSE +"HCC15","Input","KEGG_OOCYTE_MEIOSIS",0.26817,0.846,0.614,2127,0.681,"ITPR3, MOS, ADCY9, ADCY5, AR, CCNB1, ITPR2, ADCY6, PPP2R5D, CDC27, IGF1R, YWHAZ, CDC23, ANAPC7, PRKACB, ANAPC4, CDC16, PPP3CC, ITPR1, ANAPC2, ESPL1",0.211831628858832,0.166852888087215,FALSE +"HCC15","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.56931,1.83,0.0156,743,0.284,"AGA, FUCA2, FUCA1, MAN2B2, HEXA",1.80687540164554,0.546681659952962,FALSE +"HCC15","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.1544,-0.487,0.998,6739,0.996,"ATP5PD, NDUFV2, ATP6V1D, ATP5MG, NDUFA7, COX7A2L, NDUFAB1, NDUFS6, COX6C, NDUFA6, COX11, NDUFS5, ATP6V1F, PPA2, ATP5ME, UQCRC2, NDUFS4, UQCR10, COX17, ATP6V1G1, ATP6V1E1, UQCRB, UQCRFS1, UQCRQ",0.000869458712628891,0.00174066157630127,FALSE +"HCC15","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.45865,1.46,0.0916,1429,0.292,"ST3GAL1, GALNT5, C1GALT1, GALNT13, GALNT15, GALNT7, B3GNT6, C1GALT1C1",1.03810452633215,0.534617148551582,FALSE +"HCC15","Input","KEGG_P53_SIGNALING_PATHWAY",-0.24114,-0.744,0.737,6416,0.992,"TNFRSF10B, TP53I3, CASP3, CYCS, CHEK1, GTSE1, COP1, PPM1D, SERPINE1, CD82, CCND1, CDKN1A, THBS1, RCHY1, CHEK2, CCND2, CDK4, MDM2, IGFBP3, CDKN2A",0.132532512140949,0.00348832784582135,FALSE +"HCC15","Input","KEGG_PANCREATIC_CANCER",-0.28514,-0.881,0.603,8553,0.952,"ARHGEF6, RAF1, RAC2, PIK3R2, CDK4, AKT3, SMAD4, PIK3CG, RAC3, VEGFA, RB1, CDKN2A",0.219682687859849,0.0213630516155257,FALSE +"HCC15","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.54978,1.74,0.0265,1555,0.221,"BCAT1, BCAT2, PPCS, COASY",1.57675412606319,0.655607726314889,TRUE +"HCC15","Input","KEGG_PARKINSONS_DISEASE",-0.16333,-0.517,0.994,8189,1,"PPID, UQCRC2, NDUFS4, UQCR10, UBE2L3, UBE2G1, UQCRB, UQCRFS1, UQCRQ, SNCA",0.00261361560268669,0,FALSE +"HCC15","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.34997,1.12,0.267,729,0.474,"TUBB2B, OCLN, CDH1, CD14, CTNNB1, ARPC1A, CLDN1, ROCK2",0.573488738635425,0.324221658325915,FALSE +"HCC15","Input","KEGG_PATHWAYS_IN_CANCER",-0.27189,-0.841,0.628,7526,0.918,"NFKB1, BCR, DVL3, CCND1, PIK3CD, PIK3CB, CDKN1A, RHOA, CTBP1, FGFR1, LAMB2, CDKN1B, BIRC5, HGF, SOS1, ARNT, CREBBP, MECOM, FOXO1, PIAS1, RUNX1, CKS1B, LAMC1, GSK3B, E2F3, KITLG, TCF7L1, PLCG1, PLCG2, PIAS4, RAF1, RAC2, PIK3R2, PRKCB, RUNX1T1, CDK4, PDGFRB, MDM2, PIAS2, CEBPA, IL6, AKT3, SKP2, WNT10A, SMAD4, WNT5A, FN1, PAX8, FGF13, FGF2, PIK3CG, MMP2, CBLB, GRB2, RAC3, VEGFA, MAX, STK4, LAMB1, SPI1, COL4A2, MITF, FGF1, RB1, EP300, CDKN2A",0.202040356262804,0.0371573187987575,FALSE +"HCC15","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.42385,1.37,0.112,973,0.344,"UGDH, GUSB",0.950781977329818,0.46344155742847,FALSE +"HCC15","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.31498,1,0.391,505,0.57,"PFKP, TALDO1, RBKS, G6PD",0.407823242604133,0.244125144327509,FALSE +"HCC15","Input","KEGG_PEROXISOME",0.53609,1.66,0.058,2653,0.253,"SLC27A2, ABCD1, PECR, DECR2, ACSL3, PEX16, AMACR, NUDT19, PEX3, CROT, MPV17, EHHADH, ACSL1, PXMP4, AGPS, PEX1, GNPAT, PEX6, FAR1, PEX10, PRDX1, SCP2, GSTK1, PEX11B, SLC25A17, ECI2, PEX13, ACOX1, DHRS4, ACSL6, ABCD3, PHYH, CAT, CRAT",1.23657200643706,0.596879478824182,FALSE +"HCC15","Input","KEGG_PHENYLALANINE_METABOLISM",0.55262,1.74,0.0334,1123,0.221,"ALDH3A1, MAOA, ALDH3B1, GOT1",1.47625353318844,0.655607726314889,TRUE +"HCC15","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.28458,-0.887,0.573,7590,0.961,"PIK3CD, PI4KB, PIK3CB, DGKD, INPP5B, CDS1, PLCG1, DGKH, PLCG2, PIP4K2A, PIK3R2, IMPA2, PLCB2, PRKCB, INPP4B, PIK3CG, PLCZ1, INPP5D",0.24184537803261,0.0172766123314547,FALSE +"HCC15","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.45006,1.43,0.107,2433,0.297,"BLVRB, BLVRA, ALAS1, HMOX2, GUSB, HMBS, COX15, PPOX, EARS2, FECH, FTH1",0.97061622231479,0.527243550682788,FALSE +"HCC15","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.30026,-0.919,0.518,8886,0.957,"SCD, APOC3, ACSL4, LPL, FADS2, PLTP, SCD5",0.285670240254767,0.0190880622231565,FALSE +"HCC15","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.60596,-1.88,0.0226,8612,0.651,"BTK, RFX5, CD79A, RFXANK, PTPRC, RFXAP, TNFRSF13C",1.6458915608526,0.186419011431808,FALSE +"HCC15","Input","KEGG_PRION_DISEASES",0.28477,0.919,0.506,561,0.623,"IL1A, C9",0.295849483160201,0.20551195334083,FALSE +"HCC15","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.37195,1.18,0.23,2398,0.438,"MAPK13, FZR1, PIK3R3, MOS, GNAI1, ADCY9, AKT1, ADCY5, CDC25B, MAPK8, CCNB1, ADCY6, CDC27, IGF1R, CDC23, ANAPC7, PRKACB, ANAPC4, CDC16, GNAI3, MAPK9, ANAPC2, AKT2, MAPK10, PKMYT1, HSP90AB1",0.638272163982407,0.3585258894959,FALSE +"HCC15","Input","KEGG_PROPANOATE_METABOLISM",0.41893,1.29,0.157,1421,0.367,"ALDH2, MCEE, ACACA, ALDH3A2, ACACB, ALDH7A1, ECHS1, EHHADH, LDHA, ACSS2, ALDH9A1",0.804100347590766,0.435333935747911,FALSE +"HCC15","Input","KEGG_PROSTATE_CANCER",-0.37041,-1.17,0.242,7418,0.855,"HSP90B1, NFKB1, CCND1, PIK3CD, CREB1, PIK3CB, CDKN1A, PDPK1, FGFR1, CDKN1B, SOS1, CREBBP, FOXO1, GSK3B, E2F3, TCF7L1, RAF1, PIK3R2, PDGFRB, MDM2, AKT3, PIK3CG, GRB2, RB1, EP300",0.616184634019569,0.0680338852718274,FALSE +"HCC15","Input","KEGG_PROTEASOME",0.30995,0.975,0.44,3713,0.592,"PSMB8, PSME2, PSME1, PSMD1, PSMD3, PSMD12, PSMD11, PSME4, PSMB2, PSMD6, PSMA6, PSMB1, PSMB5, PSMB4, PSMA4, PSMD13, PSMC3, PSMA2, PSMC5, PSMC4, PSMD2, PSMA7, PSMA3, PSMC2, PSMA5",0.356547323513813,0.22767829327708,FALSE +"HCC15","Input","KEGG_PROTEIN_EXPORT",0.2489,0.803,0.736,2587,0.744,"SEC63, SEC11A, SRPRA, SPCS2, SRP68, SRP14, SRP72, SRP54",0.133122185662501,0.128427064454121,FALSE +"HCC15","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.40714,-1.26,0.16,8380,0.879,"ATP1B3, SLC4A4, SLC38A3, CA2",0.795880017344075,0.0560111249262281,FALSE +"HCC15","Input","KEGG_PURINE_METABOLISM",-0.17481,-0.552,0.974,6682,1,"AMPD2, APRT, PAICS, NPR2, POLD4, POLR2E, NT5C, NUDT9, PNP, POLR2L, GMPS, ITPA, NUDT2, PRPS2, PDE3B, POLR2C, PDE5A, IMPDH1, PRUNE1, POLR2G, ENTPD6, POLR2J, CANT1, NT5C3A, POLR2I, POLR2K, DCK, POLR2H, POLR3G, PDE1C, IMPDH2, POLR2F, FHIT, PDE2A",0.0114410431213845,0,FALSE +"HCC15","Input","KEGG_PYRIMIDINE_METABOLISM",-0.19577,-0.605,0.954,6792,1,"POLD4, POLR2E, NT5C, PNP, POLR2L, UCKL1, ITPA, NUDT2, POLR2C, POLR2G, UPRT, ENTPD6, POLR2J, CANT1, NT5C3A, POLR2I, TYMS, POLR2K, DCK, POLR2H, UCK2, POLR3G, POLR2F, TXNRD2",0.0204516252959049,0,FALSE +"HCC15","Input","KEGG_PYRUVATE_METABOLISM",0.53627,1.7,0.0485,1549,0.231,"ME1, ME3, GLO1, ALDH2, PC, ACACA, ALDH3A2, ACACB, ALDH7A1, DLAT, LDHA, ACSS2, ALDH9A1, PKLR",1.31425826139774,0.636388020107856,TRUE +"HCC15","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.24873,0.77,0.754,612,0.794,"ITGA1, IQGAP2, EGFR, ITGB5, CFL2, ACTN4, ITGB4, CD14, ITGA6, PIK3R3, ITGA3, IQGAP1, ITGA2, RDX, F2R, MOS, RRAS2, ARPC1A, GNA13",0.122628654130226,0.100179497572904,FALSE +"HCC15","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.18543,-0.572,0.979,6494,1,"PIK3C3, PIK3R4, GABARAPL2, ATG4B, ATG3",0.00921730819686218,0,FALSE +"HCC15","Input","KEGG_RENAL_CELL_CARCINOMA",-0.28262,-0.87,0.575,7590,0.934,"PIK3CD, PIK3CB, HGF, SOS1, ARNT, CREBBP, PAK3, PAK1, GAB1, RAF1, PIK3R2, AKT3, PIK3CG, GRB2, VEGFA, EP300",0.24033215531037,0.0296531237699066,FALSE +"HCC15","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.66735,-2.04,0.00188,7871,0.638,"CTSG, ACE, MME, ANPEP, CPA3, CTSA",2.72584215073632,0.195179321278838,FALSE +"HCC15","Input","KEGG_RETINOL_METABOLISM",0.4217,1.33,0.136,715,0.357,"CYP3A7, RETSAT, ALDH1A1",0.866461091629782,0.447331783887807,FALSE +"HCC15","Input","KEGG_RIBOFLAVIN_METABOLISM",0.41018,1.28,0.186,2858,0.371,"RFK, ACP2, FLAD1, MTMR2",0.730487055782084,0.430626090384954,FALSE +"HCC15","Input","KEGG_RIBOSOME",0.513,1.61,0.0567,2751,0.264,"RPL26L1, RPL37, RPL19, RPS4Y1, RPL34, RPS6, RPL15, RPL36A, RPL36AL, RPL26, RPS13, RPL37A, RPS11, RPL24, RSL24D1, RPL27A, RPS18, RPL7, RPL35, RPL36, RPS24, RPL13A, RPS7, RPS16, RPS26, RPL6, RPL18A, RPL27, RPL18, RPS8, FAU, RPL3, RPS3A, RPL21, RPS2, RPL32, RPL9, RPL8, RPL10A, RPL28, RPS10, RPS3, RPL35A, RPS9, RPS15A, RPS23, RPL29, RPL5, RPL4, RPS20, RPL14, RPS4X, RPL38, RPL31, RPL23A, RPL7A",1.24641694110709,0.578396073130169,FALSE +"HCC15","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.44128,1.41,0.109,3008,0.309,"MAPK13, IFIH1, ISG15, CXCL8, DDX58, NLRX1, CHUK, MAPK8, CYLD, MAPK9, NFKBIB, RIPK1, MAPK10, ATG5, CASP8, TANK, TRAF2, PIN1, IRF3, RELA, TRADD, CXCL10, CASP10, TKFC, DDX3X",0.962573502059376,0.510041520575165,FALSE +"HCC15","Input","KEGG_RNA_DEGRADATION",-0.18615,-0.583,0.97,5585,1,"CNOT8, EXOSC4, CNOT9, EXOSC6, LSM3, PAPOLG, CNOT6, CNOT2, XRN1, EDC3, CNOT3, ZCCHC7, LSM7, CNOT4, LSM8, MPHOSPH6, LSM2, LSM4, DCP1A, LSM6, DCP1B, LSM1, C1D, LSM5",0.0132282657337552,0,FALSE +"HCC15","Input","KEGG_RNA_POLYMERASE",-0.49911,-1.56,0.062,5378,0.906,"POLR1B, POLR2B, POLR3K, POLR3D, POLR3F, POLR1C, POLR1D, POLR2D, POLR3H, POLR2E, POLR2L, POLR2C, POLR2G, POLR2J, POLR2I, POLR2K, POLR2H, POLR3G, POLR2F",1.20760831050175,0.0428718023231869,FALSE +"HCC15","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.46946,1.45,0.0982,587,0.286,"GGT1, PAPSS2, MAT1A, CBS",1.00788851221305,0.543633966870957,FALSE +"HCC15","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.31449,-0.982,0.431,7083,0.961,"LAMA1, LAMA5, LAMA3, LAMA4, TRAF4, NFKB1, CCND1, PIK3CD, PIK3CB, LAMB2, CDKN1B, PIAS1, CKS1B, LAMC1, E2F3, PIAS4, PIK3R2, CDK4, PIAS2, AKT3, SKP2, FN1, PIK3CG, MAX, LAMB1, COL4A2, RB1, FHIT",0.365522729839268,0.0172766123314547,FALSE +"HCC15","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.52043,1.64,0.0399,1679,0.248,"STX3, VAMP7, VAMP8, STX5, VTI1A, VAMP2, STX12, VAMP3, STX4, STX7, BET1, YKT6, SNAP23, GOSR1",1.39902710431325,0.605548319173784,TRUE +"HCC15","Input","KEGG_SPHINGOLIPID_METABOLISM",0.47522,1.48,0.083,482,0.297,"PLPP2, UGCG, GLA, SGPL1, PLPP3",1.08092190762393,0.527243550682788,FALSE +"HCC15","Input","KEGG_SPLICEOSOME",-0.24176,-0.744,0.763,5674,0.992,"SRSF4, MAGOHB, SRSF9, DDX5, ALYREF, DHX8, THOC3, NCBP2, SF3B4, SNRNP40, HNRNPM, SF3A1, LSM3, PPIH, PPIE, HNRNPA1, SLU7, SF3B5, SNU13, SRSF2, PCBP1, U2SURP, HNRNPA3, PRPF4, TXNL4A, SRSF10, SF3B6, SRSF5, LSM7, HNRNPC, SNRPC, SRSF3, CCDC12, SF3A2, SMNDC1, SNW1, RBM8A, LSM8, SNRPA1, SART1, LSM2, SRSF1, LSM4, PRPF18, LSM6, RBM17, SF3B2, SNRPB, ZMAT2, SNRPG, CWC15, PHF5A, ISY1, PRPF40B, SYF2, LSM5",0.11747546204512,0.00348832784582135,FALSE +"HCC15","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.41088,1.29,0.168,973,0.367,"PGM2L1, UGDH, GUSB",0.774690718274137,0.435333935747911,FALSE +"HCC15","Input","KEGG_STEROID_BIOSYNTHESIS",-0.41751,-1.28,0.174,8601,0.964,"SQLE, MSMO1, FDFT1, CYP51A1",0.7594507517174,0.0159229660971692,FALSE +"HCC15","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.50366,1.59,0.0607,560,0.271,"AKR1C3, CYP21A2, CYP3A7, AKR1C1",1.21681130892474,0.567030709125594,FALSE +"HCC15","Input","KEGG_SULFUR_METABOLISM",0.87387,2.75,0,234,0.004,"SULT1A3, PAPSS2, SULT1A1",Inf,2.39794000867204,TRUE +"HCC15","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.30277,-0.967,0.458,7662,0.911,"C3, CTSG, SNRPB, ACTN3, ELANE, C4A, FCGR2B, FCGR2C",0.339134521996131,0.0404816230270017,FALSE +"HCC15","Input","KEGG_TASTE_TRANSDUCTION",0.45887,1.47,0.0809,1816,0.298,"ITPR3, ADCY6, PRKACB, KCNB1",1.09205147838773,0.525783735923745,FALSE +"HCC15","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.24242,-0.744,0.787,7277,0.992,"HMGCR, PMVK, HMGCS1",0.104025267640935,0.00348832784582135,FALSE +"HCC15","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.33064,-1.01,0.424,8504,0.947,"E2F4, SP1, AMH, SMAD4, ID3, E2F5, TFDP1, LTBP1, THBS3, DCN, EP300",0.372634143407267,0.0236500209967266,FALSE +"HCC15","Input","KEGG_THYROID_CANCER",0.21511,0.668,0.888,567,0.918,"CDH1, CTNNB1",0.051587034221399,0.0371573187987575,FALSE +"HCC15","Input","KEGG_TIGHT_JUNCTION",0.30445,0.966,0.463,888,0.593,"CLDN6, TJP1, OCLN, ACTN4, TJP2, EPB41L3, GNAI1, RRAS2, CTNNB1, SPTAN1, AKT1, CLDN1, CTNNA2, CTNNA1, LLGL2, RRAS",0.334419008982047,0.226945306635737,FALSE +"HCC15","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.31747,0.995,0.413,1198,0.564,"MAPK13, CXCL8, CD40, CD14, PIK3R3, STAT1, AKT1, CHUK, MAPK8, JUN, MAP2K6",0.384049948343599,0.248720896016658,FALSE +"HCC15","Input","KEGG_TRYPTOPHAN_METABOLISM",0.59759,1.89,0.0216,1016,0.253,"KYNU, ALDH2, MAOA, OGDH, ALDH3A2, ALDH7A1, ECHS1, OGDHL, EHHADH",1.66554624884907,0.596879478824182,FALSE +"HCC15","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.2252,0.696,0.838,1012,0.888,"PIK3R3, IRS1, CACNA1C, PDX1, MAPK8",0.0767559813697235,0.051587034221399,FALSE +"HCC15","Input","KEGG_TYPE_I_DIABETES_MELLITUS",-0.56543,-1.75,0.0301,9482,0.555,"CPE, ICA1",1.52143350440616,0.255707016877324,FALSE +"HCC15","Input","KEGG_TYROSINE_METABOLISM",0.42033,1.32,0.155,1123,0.36,"ALDH3A1, FAH, MAOA, ALDH3B1, GOT1",0.809668301829709,0.443697499232713,FALSE +"HCC15","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.31141,-0.979,0.441,7470,0.938,"MAP2K7, NFKB1, PIK3CD, PIK3CB, RHOA, PDPK1, NFATC4, SOS1, NCK2, LCP2, PAK3, PRKCQ, PAK1, NFATC1, GSK3B, PLCG1, RAF1, PIK3R2, CDK4, AKT3, VAV3, NFATC2, PIK3CG, GRAP2, NCK1, CBLB, GRB2, PTPRC",0.355561410532161,0.0277971616209356,FALSE +"HCC15","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.1932,0.609,0.943,2072,0.96,"MID1, SMURF1, FZR1, PML, CUL4B, SMURF2, DDB2, ERCC8, WWP2, WWP1, BIRC2, NEDD4, CDC27, UBE4A, UBE2H, STUB1, CDC23, ITCH, ANAPC7, ANAPC4, CDC16, SAE1, DDB1, CUL5, ANAPC2, HUWE1, UBE3B",0.0254883072626717,0.0177287669604316,FALSE +"HCC15","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.74502,2.34,0.0022,518,0.113,"BCAT1, BCAT2, IARS2",2.65757731917779,0.94692155651658,TRUE +"HCC15","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.37736,1.15,0.245,1150,0.463,"ALDH2, BCAT1, BCAT2, ACADS, MCEE, ACADSB, ALDH3A2, ALDH7A1, HADHB, ECHS1, EHHADH, AUH",0.610833915635468,0.334419008982047,FALSE +"HCC15","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.29982,0.916,0.531,1432,0.621,"KCNMA1, ITPR3, ADCY9, GNA13, ADCY5, ROCK2, CACNA1C, ARHGEF11, CALD1, NPR1, ITPR2, ADCY6, ARHGEF1, MYH11",0.274905478918531,0.20690839982342,FALSE +"HCC15","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.35858,1.13,0.288,2349,0.475,"ADCY9, DYNC1LI2, RAB11A, VAMP2, DYNC1H1, RAB5C, STX4, RAB5A, ADCY6, PRKACB, DYNLL2, RAB5B, DCTN1, NSF, DYNC1I1",0.540607512240769,0.323306390375133,FALSE +"HCC15","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.32366,-1,0.429,7590,0.943,"PIK3CD, PIK3CB, SH2D2A, NFATC4, NFATC1, PLCG1, PLCG2, RAF1, RAC2, PIK3R2, PLA2G12A, PRKCB, HSPB1, AKT3, NFATC2, PIK3CG, RAC3, VEGFA",0.367542707815276,0.0254883072626717,FALSE +"HCC15","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.43625,1.35,0.135,1019,0.35,"TJP1, TCIRG1, TJP2, ERO1A, SLC12A2, ATP6V0D1, ADCY9, ATP6V0A1, KDELR3, ATP6V0A2",0.869666231504994,0.455931955649724,FALSE +"HCC15","Input","KEGG_VIRAL_MYOCARDITIS",0.27096,0.854,0.63,519,0.694,"CD40, DMD, CXADR, ICAM1",0.200659450546418,0.158640529545145,FALSE +"HCC15","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.24023,-0.725,0.796,7533,1,"DVL3, CCND1, SFRP1, ROCK1, RHOA, CTBP1, PPP2R5E, NFATC4, LRP6, CREBBP, SENP2, NFATC1, GSK3B, TCF7L1, CCND2, RAC2, LRP5, PLCB2, PRKCB, WNT10A, SMAD4, WNT5A, CHD8, NFATC2, RAC3, VANGL2, TBL1XR1, EP300",0.0990869322623309,0,FALSE +"HCC44","Input","KEGG_ABC_TRANSPORTERS",0.27486,0.867,0.593,1943,0.78,"ABCC3, TAP2, ABCG1, ABCA1, ABCD4, ABCG2, ABCC4, ABCA3, TAP1",0.226945306635737,0.10790539730952,FALSE +"HCC44","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.36325,-1.04,0.348,7099,0.6,"PIK3CA, RAF1, AKT2, MAPK1, TCF7L2, TCF7L1, MAPK3, CCND1, GRB2, BAD, SOS1, PIK3CD, EIF4EBP1, KIT, LEF1",0.458420756053419,0.221848749616356,FALSE +"HCC44","Input","KEGG_ADHERENS_JUNCTION",-0.36307,-1.06,0.364,7376,0.64,"MAPK1, SSX2IP, TCF7L2, TCF7L1, MAPK3, ERBB2, CDH1, PTPN6, CTNNA2, CTNNA1, CTNND1, SRC, CTNNB1, WASF3, FARP2, RAC3, NECTIN4, FGFR1, PTPRF, NECTIN1, LEF1",0.438898616350944,0.193820026016113,FALSE +"HCC44","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.36766,-1.07,0.352,7212,0.658,"PRKCQ, AKT2, CAMKK2, RXRA, PRKAA1, NFKBIE, PRKAG1, RXRG, CD36, ADIPOR1, ACSL1, ACSL6",0.453457336521869,0.181774106386044,FALSE +"HCC44","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.59494,-1.73,0.0222,8712,0.434,"GLUL, ABAT, ALDH5A1, GLUD2",1.65364702554936,0.362510270487489,FALSE +"HCC44","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.34789,-1.03,0.392,6325,0.598,"ATP1B1, PIK3R1, PIK3R2, IRS1, ATP1A4, INSR, ATP1A1, ATP1A3, PIK3CA, MAPK1, MAPK3, PDPK1, SCNN1A, PIK3CD, HSD11B2",0.406713932979543,0.223298816011589,FALSE +"HCC44","Input","KEGG_ALZHEIMERS_DISEASE",-0.3673,-1.09,0.33,7130,0.645,"GNAQ, FAS, PPP3CC, COX5A, ATP5PF, PLCB3, CASP9, MAPK1, MAPK3, CDK5, APP, CASP8, MME, NCSTN, GRIN1, FADD, APH1A, CAPN1, BAD, ATP2A3, APOE, GSK3B, MAPT, CALM2, LPL, NDUFA4, CALML3, PPP3R1, PLCB4, APBB1, SNCA, BACE1",0.481486060122112,0.190440285364732,FALSE +"HCC44","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.27894,0.866,0.582,2386,0.768,"RARS2, WARS2, FARS2, MARS2, MTFMT, LARS2",0.235077015350112,0.114638779968488,FALSE +"HCC44","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.28436,0.893,0.57,2234,0.782,"GFPT2, GNPNAT1, GCK, GALE, UGDH, UXS1, PGM3, GMDS, HEXA, NANS",0.244125144327509,0.106793246940152,FALSE +"HCC44","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.26042,0.803,0.712,272,0.816,"PRPH, PRPH2, NEFH, NEFM",0.147520006363144,0.0883098412461389,FALSE +"HCC44","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.5863,1.8,0.0288,1943,0.562,"CD74, CTSS, RFXAP, TAPBP, B2M, RFX5, IFI30, CTSB, TAP2, PSME1, PSME2, PSME3, LGMN, HSPA5, CALR, TAP1",1.54060751224077,0.250263684430939,FALSE +"HCC44","Input","KEGG_APOPTOSIS",-0.21172,-0.609,0.956,7099,0.982,"PIK3CA, IL1RAP, FAS, PPP3CC, AKT2, CASP9, CASP8, ENDOD1, FADD, CASP6, CAPN1, PRKAR2B, BAD, PIK3CD, BCL2, PPP3R1, TP53",0.0195421077238999,0.00788851221305034,FALSE +"HCC44","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.63466,1.96,0.0102,99,0.567,"PTGES, PTGS2, PLA2G4A, GGT1",1.99139982823808,0.246416941107093,FALSE +"HCC44","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.3632,-1.05,0.342,8510,0.635,"GATM, GLUL, CKMT1A, GLUD2",0.465973893943865,0.197226274708024,FALSE +"HCC44","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.46641,-1.38,0.107,8197,0.566,"CTNNA2, CTNNA1, DAG1, SGCB, ITGB6, CTNNB1, PKP2, ITGA6, ITGA11, SGCG, DSC2, CACNA2D1, ITGA4, LEF1, CDH2, ITGB8",0.97061622231479,0.247183568811729,FALSE +"HCC44","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.56049,1.76,0.0232,2844,0.44,"ALDH2, ALDH1B1, UGDH, ALDH3A2, ALDH7A1",1.6345120151091,0.356547323513813,FALSE +"HCC44","Input","KEGG_AXON_GUIDANCE",-0.44133,-1.3,0.156,7185,0.58,"EPHA5, LIMK2, PPP3CC, EFNA5, EPHB1, PAK4, SEMA4C, DPYSL2, MAPK1, NTN4, ARHGEF12, MAPK3, CDK5, L1CAM, EPHA1, DPYSL5, EPHA7, EPHB4, EFNB1, EFNA1, SEMA3C, PLXNA3, PLXNA2, ROBO1, NCK2, PAK5, PAK6, GSK3B, RAC3, EPHB3, PLXNB3, PPP3R1, SEMA4D, EPHA4, EPHA3, SEMA6D, SEMA5A",0.806875401645538,0.236572006437063,FALSE +"HCC44","Input","KEGG_BASAL_CELL_CARCINOMA",-0.46082,-1.35,0.127,6849,0.6,"APC, WNT5A, FZD1, SUFU, WNT11, TCF7L2, TCF7L1, FZD6, CTNNB1, GSK3B, TP53, LEF1",0.896196279044043,0.221848749616356,FALSE +"HCC44","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.60458,1.85,0.0265,2061,0.603,"TAF12, GTF2F1, GTF2F2, GTF2E2, GTF2H2, TAF11, GTF2A2, GTF2E1, TBP, GTF2H1, GTF2H3, TAF9, TAF10, GTF2H4, GTF2B",1.57675412606319,0.219682687859849,FALSE +"HCC44","Input","KEGG_BASE_EXCISION_REPAIR",0.16293,0.495,0.995,1419,0.995,"PARP2, HMGB1, MBD4, NTHL1",0.00217691925427455,0.00217691925427455,FALSE +"HCC44","Input","KEGG_BETA_ALANINE_METABOLISM",0.23723,0.725,0.805,1312,0.882,"ALDH2, EHHADH, MLYCD, ALDH1B1",0.0942041196321315,0.0545314148681803,FALSE +"HCC44","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.31543,0.974,0.451,1391,0.699,"ELOVL5, ACOT2, ACOT1, HACD2, YOD1, ACOT7",0.345823458122039,0.155522824254319,FALSE +"HCC44","Input","KEGG_BLADDER_CANCER",0.3647,1.16,0.243,170,0.599,"MYC, MMP1, CDKN2A, VEGFA",0.614393726401688,0.222573177610689,FALSE +"HCC44","Input","KEGG_BUTANOATE_METABOLISM",-0.36396,-1.05,0.36,8659,0.635,"ACADS, ABAT, ALDH5A1, HMGCS1",0.443697499232713,0.197226274708024,FALSE +"HCC44","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.38816,-1.12,0.303,7081,0.689,"NFATC2, PIK3CA, RAF1, PPP3CC, AKT2, MAPK1, VAV2, MAPK3, BTK, NFKBIE, GRB2, PTPN6, SOS1, VAV3, GSK3B, PIK3CD, SYK, PIK3AP1, CD81, RAC3, PLCG2, PPP3R1",0.518557371497695,0.161780778092374,FALSE +"HCC44","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.33855,-0.998,0.429,6461,0.644,"ATP2B2, ATP2B4, VDAC3, TACR1, ATP2A1, PHKA2, PLCB1, SLC25A4, NOS1, SLC8A1, PLCB2, GNAQ, P2RX7, PPP3CC, CAMK2B, ADCY9, PLCB3, ITPKB, GNA11, CAMK2D, ERBB2, GRIN1, PLCG1, PLCD1, ATP2A3, CALM2, ERBB3, PLCG2, CALML3, PPP3R1, PLCB4",0.367542707815276,0.191114132640188,FALSE +"HCC44","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.38684,-1.12,0.279,6095,0.689,"COX6B1, CYC1, CACNA1F, ATP1B1, UQCRFS1, COX5B, ATP1A4, TPM4, UQCRQ, MYH7, SLC8A1, ATP1A1, ATP1A3, COX5A, TPM1, TPM3, SLC9A1, CACNA2D1",0.554395796726402,0.161780778092374,FALSE +"HCC44","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.56324,-1.62,0.0465,8461,0.448,"PTPRC, CD99, NRCAM, SDC1, CDH15, CDH3, CD276, ITGA6, VCAN, SDC4, ITGA4, PTPRF, NCAM1, NECTIN1, CADM1, SDC2, CDH4, CDH2, ITGB8, JAM3, CNTNAP2",1.33254704711005,0.348721986001856,FALSE +"HCC44","Input","KEGG_CELL_CYCLE",-0.24385,-0.717,0.813,6921,0.92,"CDC25C, WEE1, CDC45, CDKN1A, CREBBP, CDK2, BUB1B, PLK1, PTTG1, SKP1, YWHAB, CCND1, ANAPC4, CCNB3, CCNA2, CCNB2, TTK, YWHAZ, FZR1, CDC20, BUB1, CHEK1, CCNB1, GSK3B, CDK1, RB1, PKMYT1, TP53",0.0899094544059319,0.0362121726544447,FALSE +"HCC44","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.28983,-0.829,0.632,7044,0.844,"PLCB2, GNG4, PIK3CA, RAF1, AKT2, ADCY9, PLCB3, MAPK1, TIAM2, CCL13, VAV2, MAPK3, GRK2, ARRB2, ARRB1, GRB2, PRKCD, STAT1, CCL14, STAT2, GSK3A, SOS1, VAV3, GRK5, CSK, GSK3B, PIK3CD, PREX1, GRK6, PRKCZ, PLCB4",0.199282921717615,0.073657553374345,FALSE +"HCC44","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.28494,0.877,0.589,268,0.772,"MYC, TGFB1, CDKN2A, TGFB2, MECOM",0.229884705212898,0.112382699664264,FALSE +"HCC44","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.2745,0.844,0.636,1541,0.787,"SDHA, ACLY, PCK2, SDHD, SDHC, DLST",0.196542884351586,0.104025267640935,FALSE +"HCC44","Input","KEGG_COLORECTAL_CANCER",0.30816,0.961,0.45,181,0.711,"RAC2, MYC, JUN, TGFB1, TGFB2",0.346787486224656,0.148130399270234,FALSE +"HCC44","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.37428,1.14,0.269,399,0.598,"CFB, THBD, PLAUR, SERPINE1, C3, MBL2, PLAU, F8",0.570247719997592,0.223298816011589,FALSE +"HCC44","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.37767,1.19,0.238,2642,0.625,"CTH, BHMT, CBS, AHCYL1, MAT2B, GOT2, MPST, AHCYL2, MAT1A, SDS, MAT2A, MTAP",0.623423042943488,0.204119982655925,FALSE +"HCC44","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33436,1.01,0.381,546,0.658,"CXCL5, CD40, TGFB1, TNFRSF10B, VEGFA, TGFB2, BMPR2, EPO, CSF1",0.419075024324381,0.181774106386044,FALSE +"HCC44","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.26539,0.811,0.668,1093,0.812,"NFKB1, IRF3, PYCARD, POLR3G, CASP1",0.175223537524454,0.0904439707588247,FALSE +"HCC44","Input","KEGG_DILATED_CARDIOMYOPATHY",0.29172,0.884,0.626,846,0.785,"DES, TGFB1, TGFB2, ITGA1, ITGA2, LAMA2, ITGA3, ITGB3, ITGB1, GNAS, ITGA5",0.20342566678957,0.105130343254747,FALSE +"HCC44","Input","KEGG_DNA_REPLICATION",0.23591,0.739,0.792,4125,0.871,"RNASEH2A, SSBP1, RNASEH2B, RFC1, RFC3, RPA1, MCM3, POLD3, MCM6, MCM2, MCM5, RPA2, POLD1, RFC4, RFC2, MCM7, POLD2, MCM4, RPA3, POLE3, RNASEH1, RFC5",0.101274818410506,0.0599818449923368,FALSE +"HCC44","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.43405,-1.27,0.198,7376,0.579,"MAPK1, MAPK3, GRB2, SOS1, NOTCH3",0.703334809738469,0.237321436272564,FALSE +"HCC44","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.54485,-1.59,0.0599,7126,0.425,"GSTM3, GSTT2, ALDH3A1, MAOB, MAOA, MGST2, ADH4, ADH7, MGST3, GSTM1, ADH5, GSTP1, GSTM4",1.22257317761069,0.371611069949688,FALSE +"HCC44","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.45365,1.38,0.128,1597,0.46,"CDA, UPP1, TYMP, NAT2, GMPS, HPRT1, GUSB, NAT1, TPMT",0.892790030352132,0.337242168318426,FALSE +"HCC44","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.38056,-1.11,0.301,7550,0.676,"SPP1, LAMA3, LAMA4, HMMR, ITGB4, TNXB, CD36, COL1A2, DAG1, VTN, ITGB6, SDC1, ITGA6, FN1, COL1A1, ITGA11, COL3A1, SDC4, ITGA4, SDC2, THBS1, SV2B, ITGB8",0.521433504406157,0.170053304058364,FALSE +"HCC44","Input","KEGG_ENDOCYTOSIS",-0.29762,-0.883,0.582,6737,0.77,"CHMP5, HSPA1A, EPS15, TSG101, VPS4B, EHD2, CHMP2A, CHMP2B, ARFGAP2, VPS37C, VPS4A, VPS37A, RNF41, STAM2, RAB11FIP1, GRK2, ARRB2, ARRB1, DAB2, IQSEC2, RAB5B, SMAP1, GIT1, SH3GLB2, ASAP1, RAB11A, SMURF2, HSPA2, AGAP1, RAB4A, PARD6G, SRC, HSPA1L, GRK5, EPN3, ASAP3, ERBB3, GRK6, KIT, PRKCZ, SH3GL2, MVB12B",0.235077015350112,0.113509274827518,FALSE +"HCC44","Input","KEGG_ENDOMETRIAL_CANCER",-0.48139,-1.44,0.09,7099,0.6,"PIK3CA, RAF1, AKT2, CASP9, MAPK1, TCF7L2, TCF7L1, MAPK3, CCND1, GRB2, ERBB2, CDH1, BAD, CTNNA2, SOS1, CTNNA1, PDPK1, CTNNB1, GSK3B, PIK3CD, TP53, LEF1",1.04575749056068,0.221848749616356,FALSE +"HCC44","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.40431,-1.15,0.275,5983,0.677,"RELA, ATP6AP1, PTPN11, ATP6V0A2, LYN, MAPK10, ADAM17, IKBKB, ATP6V0D1, CASP3, ATP6V1B2, ATP6V1A, ATP6V1E1, MAPK14, ATP6V1B1, ATP6V0A1, ADAM10, ATP6V1C2, MAPK13, ATP6V1H, ATP6V1F, MAPK12, GIT1, ATP6V1C1, ATP6V1D, F11R, PLCG1, PTPRZ1, SRC, CSK, PLCG2, JAM3",0.560667306169737,0.169411331314856,FALSE +"HCC44","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.33069,-0.963,0.446,7099,0.68,"PIK3CA, RAF1, CDKN1A, CAMK2B, AKT2, PAK4, MAPK1, MAPK3, CAMK2D, GRB2, ERBB2, BAD, PLCG1, SOS1, SRC, NCK2, PAK5, PAK6, GSK3B, PIK3CD, AREG, ERBB3, EIF4EBP1, PLCG2",0.350665141287858,0.167491087293764,FALSE +"HCC44","Input","KEGG_ETHER_LIPID_METABOLISM",0.44664,1.41,0.11,1947,0.442,"PLA2G4A, PLPP3, LPCAT1, PLD1, PLA2G12A, CHPT1, PLPP2",0.958607314841775,0.354577730650908,FALSE +"HCC44","Input","KEGG_FATTY_ACID_METABOLISM",-0.36034,-1.07,0.323,8430,0.658,"ADH4, ADH7, ACADS, ACSL1, ADH5, ACSL6",0.490797477668897,0.181774106386044,FALSE +"HCC44","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.35271,-1.04,0.373,6863,0.6,"MAPK14, GAB2, PIK3CA, RAF1, AKT2, MAPK13, MAPK1, VAV2, MAPK3, BTK, MAPK12, GRB2, PRKCD, PLCG1, SOS1, MAP2K6, VAV3, PDPK1, PIK3CD, SYK, RAC3, PLCG2",0.428291168191312,0.221848749616356,FALSE +"HCC44","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.27993,-0.812,0.671,7099,0.834,"PIK3CA, RAF1, LIMK2, AKT2, MAPK1, PLPP1, VAV2, MAPK3, MYO10, ARPC1A, ASAP1, PRKCD, PLCG1, VAV3, PTPRC, SCIN, WASF3, MARCKSL1, PIK3CD, SYK, ASAP3, GSN, PLCG2",0.173277479831008,0.0788339493622613,FALSE +"HCC44","Input","KEGG_FOCAL_ADHESION",0.27716,0.846,0.638,986,0.796,"RAC2, FLNC, JUN, LAMC2, VEGFA, COL4A1, ZYX, ITGA1, LAMB3, LAMB1, ITGA2, CAV2, FLNB, ACTN1, COL4A2, LAMA2, ACTN4, ITGA3, ITGB3, COL6A1, FLNA, BIRC2, ACTN2, ITGB1, ITGA5, VCL, MYLK, MYL12A, MYL9, COL6A2",0.195179321278838,0.0990869322623309,FALSE +"HCC44","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.64236,-1.88,0.0175,8355,0.298,"DHFR, GCH1, ALPI, ALPP",1.75696195131371,0.525783735923745,FALSE +"HCC44","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.53878,-1.56,0.0776,6785,0.413,"PFKL, ALDOA, AKR1B10, MTMR6, HK1, PFKFB2, MPI, PFKFB4, ALDOC, FBP1, ALDOB, KHK",1.11013827874181,0.384049948343599,FALSE +"HCC44","Input","KEGG_GALACTOSE_METABOLISM",-0.2428,-0.711,0.832,7781,0.909,"HK1, GAA, GALT",0.0798766737092761,0.0414361167780325,FALSE +"HCC44","Input","KEGG_GAP_JUNCTION",-0.26558,-0.768,0.771,7044,0.865,"PLCB2, GNAQ, RAF1, CSNK1D, ADCY9, PLCB3, MAPK1, MAPK3, GNA11, GRB2, SOS1, SRC, CDK1, PLCB4",0.112945621949043,0.0629838925351858,FALSE +"HCC44","Input","KEGG_GLIOMA",-0.42945,-1.27,0.18,7099,0.579,"PIK3CA, RAF1, CDKN1A, CAMK2B, AKT2, MAPK1, MAPK3, CCND1, CAMK2D, GRB2, PLCG1, SOS1, PIK3CD, CALM2, RB1, PLCG2, CALML3, TP53",0.744727494896694,0.237321436272564,FALSE +"HCC44","Input","KEGG_GLUTATHIONE_METABOLISM",-0.37557,-1.1,0.311,7126,0.667,"GSTM3, GSTT2, IDH2, RRM2, PGD, IDH1, GPX2, MGST2, MGST3, OPLAH, GSTM1, RRM2B, GSTP1, GSTM4",0.507239610973163,0.175874166083451,FALSE +"HCC44","Input","KEGG_GLYCEROLIPID_METABOLISM",0.24485,0.752,0.724,1947,0.873,"PLPP3, GPAT3, ALDH2, GK, DGKE, ALDH1B1, AGK, AGPAT1, PLPP2",0.140261433802853,0.0589857562944303,FALSE +"HCC44","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.3003,0.919,0.495,2217,0.77,"PLA2G4A, PLPP3, GPAT3, LPCAT1, MBOAT7, PLD1, PTDSS2, DGKE, PLA2G12A, CDS1, CHPT1, AGPAT1, PLPP2, PTDSS1, AGPAT2",0.305394801066431,0.113509274827518,FALSE +"HCC44","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.33536,-0.986,0.428,7499,0.657,"MAOB, GAMT, PHGDH, MAOA, GLDC, GATM, SARDH",0.368556230986828,0.182434630440219,FALSE +"HCC44","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.44793,-1.33,0.148,8430,0.567,"ADH4, ADH7, ALDOC, ACSS2, FBP1, ALDOB, ADH5, ACSS1, PGAM2",0.829738284605043,0.246416941107093,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.44936,1.37,0.145,2434,0.416,"DSE, CHST12, CHST7, B3GALT6, CHPF, CHSY3",0.838631997765025,0.380906669373257,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.35868,-1.04,0.359,5526,0.6,"EXTL2, B3GAT3, GLCE, NDST1, HS2ST1, EXTL3, EXT2",0.444905551421681,0.221848749616356,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.51964,1.61,0.0661,826,0.347,"ST3GAL2, B4GALT1, FUT8",1.17979854051436,0.459670525209126,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.32816,1.01,0.359,1110,0.658,"IDS, IDUA, GUSB, NAGLU",0.444905551421681,0.181774106386044,FALSE +"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.37161,1.18,0.23,2769,0.622,"ST3GAL2, SLC33A1, HEXA, GLB1",0.638272163982407,0.206209615309181,FALSE +"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.38117,1.19,0.231,2169,0.625,"ST3GAL2, B3GALNT1, HEXA",0.636388020107856,0.204119982655925,FALSE +"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.38501,1.2,0.223,820,0.65,"FUT4, B4GALT1",0.651695136951839,0.187086643357144,FALSE +"HCC44","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.24229,-0.714,0.836,5223,0.915,"PIGG, PIGS, PIGK, PIGH, PIGO, PIGT, GPAA1, PIGU, PIGQ, PGAP1",0.0777937225609836,0.0385789059335517,FALSE +"HCC44","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.34536,1.06,0.347,2243,0.651,"MTHFD2, MTHFD1L, MTHFD1",0.459670525209126,0.186419011431808,FALSE +"HCC44","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.29929,-0.869,0.594,6782,0.788,"PLCB1, MAP3K3, MAPK14, PLCB2, GNAQ, RAF1, CAMK2B, MAPK13, ADCY9, PLCB3, MAPK1, MAP3K4, MAPK3, GNA11, MAPK12, CAMK2D, GRB2, PRKCD, SOS1, MAP2K6, SRC, CGA, CALM2, CALML3, PLCB4",0.226213555018806,0.103473782510445,FALSE +"HCC44","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.35594,-1.06,0.362,6848,0.64,"CSNK1G3, WNT5A, BTRC, CSNK1E, SUFU, CSNK1D, WNT11, CSNK1G1, CSNK1A1, BMP6, GSK3B",0.441291429466834,0.193820026016113,FALSE +"HCC44","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.52514,1.63,0.0591,846,0.349,"ANPEP, CD37, ITGA1, CD44, ITGA2, EPO, CSF1, CD38, ITGA3, ITGB3, CD55, ITGA5",1.22841251911874,0.45717457304082,FALSE +"HCC44","Input","KEGG_HISTIDINE_METABOLISM",0.33112,1.01,0.378,677,0.658,"ALDH1A3, ALDH2, ALDH3B1",0.422508200162775,0.181774106386044,FALSE +"HCC44","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.26237,0.812,0.672,3877,0.823,"SSBP1, RAD50, NBN, TOP3B, RPA1, EME1, POLD3, MRE11, RPA2, POLD1, POLD2, RPA3",0.172630726946175,0.0846001647877302,FALSE +"HCC44","Input","KEGG_HUNTINGTONS_DISEASE",0.17395,0.546,0.99,3114,1,"SOD2, TGM2, SDHA, POLR2I, ATP5MC2, NDUFA10, NDUFA7, SDHD, POLR2K, SDHC, NDUFC1, NDUFV3, TBP, AP2A1, UQCRH, RCOR1, NDUFS6, NDUFS5, AP2B1, NDUFB7, AP2S1, PPID, DNAL1, TFAM, NDUFS3, NDUFA3, NDUFA5, NDUFV1, CYCS, ITPR1, HAP1, GPX1, AP2A2, NDUFB4, NDUFS8, VDAC1, IFT57, HDAC2, NDUFA2, NDUFB9, NDUFA8, BAX, NDUFS2, SDHB, NDUFS4, COX7A2L, NDUFB1, AP2M1, DLG4, DCTN1",0.00436480540245009,0,FALSE +"HCC44","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.33486,-0.98,0.458,7785,0.657,"TPM1, PRKAG1, ITGB4, TPM3, IL6, DAG1, SGCB, ACE, ITGB6, ITGA6, ITGA11, SGCG, CACNA2D1, ITGA4, ITGB8",0.339134521996131,0.182434630440219,FALSE +"HCC44","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.43038,-1.29,0.179,6671,0.579,"PI4KA, PLCB1, PIP4K2C, PLCB2, PIK3CA, INPP1, PI4KB, PLCB3, ITPKB, IMPA2, INPPL1, PLCG1, ISYNA1, PLCD1, INPP5A, PIK3CD, PLCG2, PLCB4",0.747146969020107,0.237321436272564,FALSE +"HCC44","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.31983,-0.941,0.465,6396,0.712,"SHC1, ELK1, PIK3R1, PYGB, PIK3R2, IRS1, GYS1, RAPGEF1, EIF4E2, PHKA2, INSR, PTPN1, PIK3CA, TSC2, FASN, RAF1, AKT2, MAPK1, PRKAA1, MAPK3, GRB2, HK1, PRKAG1, PRKAR2B, BAD, SOS1, PDPK1, GSK3B, PIK3CD, CALM2, PTPRF, EIF4EBP1, PDE3A, FBP1, CALML3, PRKCZ",0.332547047110046,0.147520006363144,FALSE +"HCC44","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.52442,1.66,0.0481,102,0.343,"CD40, TGFB1",1.31785492362617,0.464705879957229,FALSE +"HCC44","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.30632,-0.905,0.538,6961,0.749,"IL10RB, TYK2, PIK3CA, AKT2, CREBBP, STAM2, CCND1, IFNGR1, IL13RA1, GRB2, OSM, PTPN6, STAT1, STAT2, PIAS1, IL6, SOS1, LIFR, IFNAR1, IL13RA2, IL6ST, PIK3CD",0.269217724333611,0.125518182300534,FALSE +"HCC44","Input","KEGG_LEISHMANIA_INFECTION",0.55087,1.78,0.0284,281,0.488,"ITGB2, PTGS2, JUN, TGFB1, CYBA, TGFB2, C3, NCF2",1.54668165995296,0.311580177997289,FALSE +"HCC44","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.32492,1.01,0.422,961,0.658,"RAC2, ITGB2, ICAM1, CYBA, CLDN11, NCF2, MSN, ACTN1, ACTN4, ACTN2, ITGB1, VCL, MYL12A, MYL9",0.374687549038326,0.181774106386044,FALSE +"HCC44","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.53891,1.67,0.0283,1312,0.364,"ALDH2, EHHADH, YOD1, ALDH1B1",1.54821356447571,0.438898616350944,FALSE +"HCC44","Input","KEGG_LONG_TERM_DEPRESSION",-0.26772,-0.782,0.722,6096,0.85,"LYN, GNAI3, ARAF, GNAI1, PPP2CA, PLCB1, NOS1, GNA13, PLCB2, GNAQ, RAF1, PLCB3, MAPK1, MAPK3, GNA11, GNA12, GNAO1, PLCB4",0.141462802430361,0.0705810742857073,FALSE +"HCC44","Input","KEGG_LONG_TERM_POTENTIATION",-0.36226,-1.09,0.31,6646,0.645,"RPS6KA1, EP300, PLCB1, RPS6KA6, PLCB2, GNAQ, RAF1, PPP3CC, CAMK2B, CREBBP, PLCB3, MAPK1, MAPK3, CAMK2D, GRIN1, CALM2, CALML3, PPP3R1, PLCB4",0.508638306165727,0.190440285364732,FALSE +"HCC44","Input","KEGG_LYSINE_DEGRADATION",0.24475,0.751,0.759,1718,0.862,"PLOD2, ALDH2, AASS, SETD7, EHHADH, ALDH1B1, PLOD1, PLOD3, DLST, GCDH",0.11975822410452,0.0644927341752872,FALSE +"HCC44","Input","KEGG_LYSOSOME",-0.20812,-0.595,0.956,6740,0.984,"GLA, SMPD1, ACP5, ATP6V0A1, PSAP, AP3M2, CLN3, NPC2, HGSNAT, ATP6V1H, CTSA, AP1S2, SLC11A2, NAGA, CD63, SORT1, AP4E1, SCARB2, LIPA, ASAH1, LAPTM4B, AP1M2, ABCA2, NEU1, CTSF, GAA, GM2A, AP3B2, CTSH, GALC",0.0195421077238999,0.00700490156865849,FALSE +"HCC44","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.3273,1,0.39,502,0.662,"RAC2, MYC, FLNC, JUN, ATF4, PLA2G4A, TGFB1, TGFB2, NFKB2, RELB, MECOM, MKNK1, FLNB, MOS, FGF13, FGF2, ELK4, DDIT3",0.408935392973501,0.1791420105603,FALSE +"HCC44","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.72348,2.28,0.00253,1780,0.176,"IAPP, GCK, HES1, FOXA2",2.59687947882418,0.75448733218585,TRUE +"HCC44","Input","KEGG_MELANOGENESIS",-0.55602,-1.62,0.0583,6694,0.448,"EP300, PLCB1, WNT5A, FZD1, PLCB2, GNAQ, RAF1, CAMK2B, CREBBP, WNT11, ADCY9, PLCB3, MAPK1, TCF7L2, TCF7L1, MAPK3, CAMK2D, FZD6, CTNNB1, GSK3B, CALM2, GNAO1, KIT, CALML3, PLCB4, LEF1",1.23433144524099,0.348721986001856,FALSE +"HCC44","Input","KEGG_MELANOMA",-0.34994,-1.04,0.372,7099,0.6,"PIK3CA, RAF1, CDKN1A, AKT2, MAPK1, MAPK3, CCND1, CDH1, BAD, HGF, PIK3CD, RB1, FGFR1, TP53",0.429457060118102,0.221848749616356,FALSE +"HCC44","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.58979,-1.71,0.0385,7957,0.375,"AKR1C2, AKR1C3, AKR1C1, EPHX1, MGST2, ADH4, ADH7, MGST3, CYP1A1, GSTM1, ADH5, GSTP1, GSTM4",1.4145392704915,0.425968732272281,FALSE +"HCC44","Input","KEGG_MISMATCH_REPAIR",0.36698,1.14,0.251,3877,0.598,"SSBP1, MLH1, MSH3, RFC1, RFC3, PMS2, RPA1, POLD3, MSH2, RPA2, POLD1, RFC4, RFC2, POLD2, RPA3",0.600326278518962,0.223298816011589,FALSE +"HCC44","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.39091,-1.16,0.247,5532,0.691,"AKT1, RPS6KA3, RPS6KB2, RPS6KA2, BRAF, RPS6KB1, PIK3CB, RICTOR, STRADA, PIK3R1, PIK3R2, RPS6KA1, CAB39, EIF4E2, RPS6KA6, PIK3CA, TSC2, AKT2, ULK1, MAPK1, PRKAA1, MAPK3, CAB39L, PDPK1, PIK3CD, EIF4EBP1",0.607303046740334,0.160521952625802,FALSE +"HCC44","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.29373,0.914,0.498,140,0.766,"RAC2, ITGB2, ICAM1, TNFRSF10B",0.302770657240282,0.115771230367396,FALSE +"HCC44","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.28383,-0.842,0.645,7533,0.829,"CHRNE, GRIN1, PLG, F2, CGA, HCRTR1",0.190440285364732,0.0814454694497265,FALSE +"HCC44","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.3974,-1.17,0.239,6584,0.708,"PIK3R2, IRS1, RAPGEF1, RPS6KA1, GAB1, MAP3K3, MAPK14, RPS6KA6, SH2B1, PIK3CA, RAF1, CAMK2B, AKT2, MAPK13, MAPK1, YWHAB, MAPK3, MAPK12, NFKBIE, CAMK2D, GRB2, YWHAZ, SORT1, PRKCD, BAD, PLCG1, SOS1, MAPKAPK2, PDPK1, FRS2, CSK, GSK3B, PIK3CD, CALM2, BCL2, MAGED1, PLCG2, ARHGDIB, CALML3, TP53, TP73, NGFR",0.621602099051862,0.149966742310231,FALSE +"HCC44","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.38997,1.17,0.245,806,0.62,"NAMPT, NT5E, NNMT, PNP, CD38, ENPP1",0.610833915635468,0.207608310501746,FALSE +"HCC44","Input","KEGG_NITROGEN_METABOLISM",-0.68798,-1.96,0.0133,8712,0.243,"GLUL, CA3, GLUD2",1.87614835903291,0.614393726401688,TRUE +"HCC44","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.19739,-0.582,0.961,7323,0.982,"MAPK13, MAPK1, CCL13, MAPK3, MAPK12, CASP8, IL6, CARD8, TAB3",0.0172766123314547,0.00788851221305034,FALSE +"HCC44","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.33699,1.03,0.386,3676,0.679,"XRCC4, XRCC5, RAD50, LIG4, MRE11, XRCC6, DCLRE1C, PRKDC",0.413412695328245,0.168130225719498,FALSE +"HCC44","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.3733,-1.09,0.331,7099,0.645,"PIK3CA, RAF1, AKT2, CASP9, MAPK1, RXRA, MAPK3, CCND1, GRB2, ERBB2, RXRG, BAD, PLCG1, SOS1, PDPK1, PIK3CD, RB1, PLCG2, TP53",0.480172006224281,0.190440285364732,FALSE +"HCC44","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.54645,-1.58,0.0664,7246,0.41,"CREBBP, LFNG, MAML2, NCSTN, DLL1, APH1A, DLL3, JAG1, DTX3L, NOTCH3, DLL4",1.17783192063198,0.387216143280265,FALSE +"HCC44","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.1578,0.495,0.992,7687,0.995,"ERCC2, GTF2H2, CCNH, GTF2H1, GTF2H3, GTF2H4, MNAT1, RFC1, RFC3, RPA1, POLD3, XPA, ERCC5, RPA2, POLD1, RFC4, RFC2, POLD2, RAD23A, RPA3, CDK7, POLE3, RFC5, POLD4, POLE4, ERCC4, CUL4A, ERCC3, LIG1, PCNA, CUL4B, DDB2, RAD23B, GTF2H5, DDB1, XPC, POLE, ERCC6, CETN2",0.00348832784582135,0.00217691925427455,FALSE +"HCC44","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.40193,-1.15,0.274,9117,0.677,"MAN1C1",0.562249437179612,0.169411331314856,FALSE +"HCC44","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.57695,-1.71,0.0392,7230,0.375,"CAMK2B, ARRB2, CAMK2D, CLCA2, CALM2, CALML3",1.40671393297954,0.425968732272281,FALSE +"HCC44","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.36623,1.16,0.238,2243,0.599,"MTHFD2, MTHFR, SHMT2, MTHFD1L, GART, MTFMT, MTHFD1",0.623423042943488,0.222573177610689,FALSE +"HCC44","Input","KEGG_OOCYTE_MEIOSIS",-0.44054,-1.3,0.159,6898,0.58,"PPP2R5A, CDC25C, RPS6KA6, BTRC, PPP2R5D, PPP2R5B, PPP3CC, CAMK2B, ADCY9, CDK2, MAPK1, AURKA, PLK1, PTTG1, SKP1, YWHAB, MAPK3, ANAPC4, CCNB2, MAPK12, SGO1, CAMK2D, YWHAZ, CDC20, BUB1, CCNB1, CDK1, FBXO5, CALM2, PKMYT1, CALML3, PPP3R1",0.798602875679548,0.236572006437063,FALSE +"HCC44","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.46926,1.43,0.119,2769,0.489,"FUCA1, FUCA2, MAN2B2, MAN2B1, MANBA, HEXA, ENGASE, GLB1",0.924453038607469,0.31069114087638,FALSE +"HCC44","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.17295,0.535,0.995,3054,1,"COX11, SDHA, ATP5MC2, COX17, TCIRG1, NDUFA10, NDUFA7, SDHD, SDHC, NDUFC1, NDUFV3, UQCRH, NDUFS6, NDUFS5, NDUFB7, NDUFA11, NDUFS3, NDUFA3, NDUFA5, ATP5ME, NDUFV1, NDUFB4, NDUFS8, NDUFA2, NDUFB9, NDUFA8, NDUFS2, SDHB, NDUFS4, COX7A2L, NDUFB1",0.00217691925427455,0,FALSE +"HCC44","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.55789,1.73,0.0367,1574,0.422,"GALNT14, GALNT11, GALNT6, ST3GAL2, C1GALT1, GALNT15, C1GALT1C1, GALNT16, GALNT17",1.43533393574791,0.374687549038326,FALSE +"HCC44","Input","KEGG_P53_SIGNALING_PATHWAY",-0.39537,-1.16,0.247,7115,0.691,"TSC2, FAS, CDKN1A, CDK2, CASP9, RRM2, CCND1, CCNB3, COP1, CCNB2, CASP8, CHEK1, CCNB1, IGFBP3, CDK1, THBS1, RRM2B, TP53, TP73",0.607303046740334,0.160521952625802,FALSE +"HCC44","Input","KEGG_PANCREATIC_CANCER",0.33514,1.06,0.328,181,0.651,"RAC2, TGFB1, CDKN2A, TGFA, VEGFA, TGFB2",0.484126156288321,0.186419011431808,FALSE +"HCC44","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.32182,-0.939,0.501,6600,0.706,"PPCDC, BCAT2, PANK2, DPYD, PPCS",0.300162274132754,0.151195298948196,FALSE +"HCC44","Input","KEGG_PARKINSONS_DISEASE",0.20479,0.628,0.957,3177,0.985,"UCHL1, SDHA, UBE2J2, ATP5MC2, NDUFA10, NDUFA7, SDHD, SDHC, NDUFC1, NDUFV3, UQCRH, NDUFS6, NDUFS5, NDUFB7, SLC18A1, PPID, NDUFS3, NDUFA3, NDUFA5, NDUFV1, CYCS, NDUFB4, NDUFS8, PARK7, VDAC1, NDUFA2, NDUFB9, NDUFA8, NDUFS2, SDHB, NDUFS4, COX7A2L, NDUFB1, HTRA2, NDUFC2",0.0190880622231565,0.00656376950238827,FALSE +"HCC44","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.17262,-0.517,0.981,7725,0.999,"YWHAZ, CDH1, ARPC1A, NCK2, CTNNB1",0.0083309926200515,0.000434511774017692,FALSE +"HCC44","Input","KEGG_PATHWAYS_IN_CANCER",0.29139,0.904,0.539,654,0.773,"RAC2, PTGS2, TRAF1, SMO, MYC, MMP1, JUN, TGFB1, CDKN2A, TGFA, LAMC2, VEGFA, TGFB2, COL4A1, NFKB2, MECOM, LAMB3, LAMB1, ITGA2, COL4A2, FGF13, FGF2, LAMA2, ITGA3, NFKB1",0.268411234813261,0.111820506081675,FALSE +"HCC44","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.27016,-0.801,0.709,6692,0.845,"XYLB, RPE, CRYL1, DCXR",0.149353764816933,0.0731432910503077,FALSE +"HCC44","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.2787,-0.824,0.676,8757,0.831,"ALDOC, FBP1, ALDOB",0.170053304058364,0.080398976215889,FALSE +"HCC44","Input","KEGG_PEROXISOME",-0.35755,-1.06,0.357,7202,0.64,"PEX11A, PECR, IDH2, NUDT12, PRDX5, SLC27A2, ACOX1, IDH1, PMVK, PXMP4, CROT, PHYH, EPHX2, AMACR, ACSL1, MVK, FAR1, ACSL6",0.447331783887807,0.193820026016113,FALSE +"HCC44","Input","KEGG_PHENYLALANINE_METABOLISM",-0.3629,-1.04,0.364,7308,0.6,"ALDH3A1, PRDX6, MAOB, MAOA, TAT, DDC",0.438898616350944,0.221848749616356,FALSE +"HCC44","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.35587,-1.03,0.385,6489,0.598,"PIK3R1, PIK3R2, PI4KA, PLCB1, PIP4K2C, DGKZ, PLCB2, PIK3CA, INPP1, PI4KB, PLCB3, DGKD, ITPKB, IMPA2, INPPL1, PLCG1, PLCD1, INPP5A, PIK3CD, CALM2, PLCG2, CALML3, PLCB4",0.414539270491499,0.223298816011589,FALSE +"HCC44","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.26804,-0.783,0.71,7116,0.858,"BLVRA, COX15, HMOX1, ALAD, BLVRB, FTH1",0.148741651280925,0.0665127121512946,FALSE +"HCC44","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.42759,-1.25,0.216,7011,0.58,"SLC27A1, UBC, OLR1, RXRA, ANGPTL4, SLC27A2, FABP3, ACOX1, FADS2, RXRG, CD36, FABP4, PDPK1, CYP27A1, SCD, SCD5, FABP7, LPL, APOC3, ACSL1, ACSL6",0.665546248849069,0.236572006437063,FALSE +"HCC44","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.48641,1.53,0.0665,871,0.428,"CD40, RFXAP, RFX5, TAP2",1.1771783546969,0.368556230986828,FALSE +"HCC44","Input","KEGG_PRION_DISEASES",-0.31073,-0.914,0.494,6344,0.742,"NOTCH1, ELK1, STIP1, HSPA1A, MAPK1, LAMC1, MAPK3, C9, IL6, NCAM1",0.306273051076353,0.129596094720973,FALSE +"HCC44","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.46332,-1.34,0.143,5532,0.571,"AKT1, RPS6KA3, MAPK9, HSP90AA1, RPS6KA2, BRAF, GNAI2, KRAS, PIK3CB, MAD2L1, ANAPC7, MAPK10, GNAI3, ARAF, ADCY5, GNAI1, PIK3R1, PIK3R2, RPS6KA1, MAPK14, CDC25C, RPS6KA6, PIK3CA, RAF1, AKT2, MAPK13, ADCY9, CDK2, MAPK1, PLK1, MAPK3, ANAPC4, CCNB3, CCNA2, CCNB2, MAPK12, FZR1, BUB1, CCNB1, PIK3CD, CDK1, PDE3A, PKMYT1",0.844663962534938,0.243363891754152,FALSE +"HCC44","Input","KEGG_PROPANOATE_METABOLISM",-0.37351,-1.1,0.311,8834,0.667,"ACSS2, ABAT, ACSS1",0.507239610973163,0.175874166083451,FALSE +"HCC44","Input","KEGG_PROSTATE_CANCER",-0.47638,-1.42,0.109,7099,0.608,"PIK3CA, RAF1, CDKN1A, AKT2, CREBBP, CDK2, CASP9, MAPK1, TCF7L2, TCF7L1, MAPK3, CCND1, GRB2, ERBB2, BAD, SOS1, PDPK1, CTNNB1, GSK3B, PIK3CD, BCL2, RB1, FGFR1, GSTP1, TP53, LEF1",0.962573502059376,0.216096420727265,FALSE +"HCC44","Input","KEGG_PROTEASOME",0.58921,1.72,0.0351,3061,0.339,"PSMB10, PSMB9, PSMB8, PSME1, PSMA6, PSME4, PSMB4, PSMC2, PSME2, PSME3, PSMD2, PSMA4, PSMC1, PSMB3, PSMC5, PSMA3, PSMA8, PSMD8, PSMD13, PSMD4, PSMA5, PSMD1, PSMD12, PSMC4, PSMA7, PSMD14, PSMD11, PSMC6, PSMA1, PSMD6, PSMC3, PSMD7, PSMF1, PSMB1, PSMB2, PSMD3",1.45469288353418,0.469800301796918,FALSE +"HCC44","Input","KEGG_PROTEIN_EXPORT",0.34728,1.07,0.331,3320,0.667,"SEC61B, SEC61A1, SRP19, SRP72, SEC62, HSPA5, SRPRA, SRP68, OXA1L, SPCS1, SRP54, SEC63, SRPRB",0.480172006224281,0.175874166083451,FALSE +"HCC44","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.59487,-1.75,0.0312,9114,0.453,"GLUD2",1.50584540598156,0.343901797987168,FALSE +"HCC44","Input","KEGG_PURINE_METABOLISM",0.26579,0.792,0.675,1982,0.812,"FHIT, NT5E, POLR2I, PNP, PNPT1, ENPP1, AK4, GMPS, PFAS, HPRT1, POLR3G, PAICS, PRPS1, PRPS1L1, PDE6C, POLR1E, ADSL, POLR2K, GART, PPAT, GDA, NME7, DGUOK, PDE4D, NUDT5, GMPR2, APRT, ADK, PDE6D, ENTPD4",0.170696227168975,0.0904439707588247,FALSE +"HCC44","Input","KEGG_PYRIMIDINE_METABOLISM",0.22738,0.71,0.81,1354,0.894,"CDA, NT5E, UPP1, TXNRD1, POLR2I, PNP, TYMP, PNPT1, DHODH, POLR3G, POLR1E, AK3, POLR2K",0.0915149811213502,0.0486624812040823,FALSE +"HCC44","Input","KEGG_PYRUVATE_METABOLISM",-0.22222,-0.647,0.913,8834,0.965,"ACSS2, ACSS1",0.039529222465701,0.0154726866562074,FALSE +"HCC44","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.25467,0.792,0.694,961,0.812,"RAC2, ITGB2, ITGA1, CFL2, ITGA2, MSN, MYH9, DIAPH2, ACTN1, MOS, FGF13, FGF2, SSH1, ACTN4, ITGA3, DIAPH3, ITGB3, PIP4K2A, ARHGEF1, ACTN2, ITGB1, LIMK1, ITGA5, VCL, MYLK, MYL12A, MYL9",0.158640529545145,0.0904439707588247,FALSE +"HCC44","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.47454,-1.4,0.124,6794,0.583,"GABARAPL1, GABARAPL2, ATG4D, ULK1, PRKAA1, ATG4B",0.906578314837765,0.234331445240986,FALSE +"HCC44","Input","KEGG_RENAL_CELL_CARCINOMA",0.33432,1.03,0.349,181,0.679,"JUN, TGFB1, TGFA, VEGFA, TGFB2",0.45717457304082,0.168130225719498,FALSE +"HCC44","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.35719,1.1,0.288,1130,0.641,"ANPEP, LNPEP, THOP1",0.540607512240769,0.193141970481183,FALSE +"HCC44","Input","KEGG_RETINOL_METABOLISM",-0.47464,-1.38,0.136,7497,0.566,"RETSAT, PNPLA4, RDH16, ADH4, ADH7, CYP1A1, ADH5, ALDH1A1",0.866461091629782,0.247183568811729,FALSE +"HCC44","Input","KEGG_RIBOFLAVIN_METABOLISM",0.46958,1.49,0.0907,806,0.427,"ACP6, ENPP1",1.0423927129399,0.369572124974976,FALSE +"HCC44","Input","KEGG_RIBOSOME",0.50097,1.52,0.0637,3274,0.412,"RPL37, RPL29, RPL24, RSL24D1, RPS25, RPL11, RPL27, RPL22, RPL18, RPL4, RPL38, RPL12, RPS7, RPL17, RPL32, RPL9, RPL26, RPL37A, RPL28, RPL30, FAU, RPL27A, RPL36, RPL5, RPS27L, MRPL13, RPL13, RPL14, RPL10A, RPS29, RPL3, RPL18A, RPL10, RPL15, RPL35A, RPSA, RPL34, RPL23, RPS16, RPS12, RPLP0, RPL7, RPL36A, RPL36AL, RPL21, RPS11, RPL19, RPL7A, RPS6, RPL23A, RPL13A, RPL6, RPS15A, RPLP1, RPS20, RPS28, RPS21, RPS24, RPS23, RPL35, RPS10, RPL8, RPS3A",1.19586056766465,0.385102783966865,FALSE +"HCC44","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.16714,-0.491,0.998,5983,0.994,"RELA, MAPK10, IKBKB, MAP3K7, MAP3K1, MAPK14, IFIH1, MAPK13, MAPK12, CASP8, DDX58, FADD, TKFC",0.000869458712628891,0.00261361560268669,FALSE +"HCC44","Input","KEGG_RNA_DEGRADATION",0.45354,1.37,0.122,1963,0.416,"EXOSC2, EXOSC9, DIS3, EXOSC1, PNPT1, DCPS, EXOSC5, EXOSC8, EXOSC6, EXOSC3, EXOSC7, DCP2, MTREX, EXOSC4, PAPOLA, ZCCHC7, EXOSC10, LSM6, MPHOSPH6, LSM2",0.913640169325252,0.380906669373257,FALSE +"HCC44","Input","KEGG_RNA_POLYMERASE",0.3448,1.07,0.327,2931,0.667,"POLR2I, POLR3G, POLR1E, POLR2K, POLR3H, POLR1A, POLR3F, POLR3C",0.485452247339714,0.175874166083451,FALSE +"HCC44","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.54971,1.72,0.0495,2526,0.339,"CTH, GGT1, SCLY, CBS, AHCYL1, MAT2B, MARS2, AHCYL2, MAT1A, BUD23, MAT2A",1.30539480106643,0.469800301796918,FALSE +"HCC44","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.40313,1.27,0.167,799,0.546,"PTGS2, TRAF1, MYC, FHIT, LAMC2, COL4A1, LAMB3, LAMB1, ITGA2, COL4A2, LAMA2, ITGA3, NFKB1, BIRC2, ITGB1",0.777283528852417,0.262807357295263,FALSE +"HCC44","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.27597,0.834,0.644,1519,0.793,"STX11, VAMP5, BET1, VAMP3, STX10, STX16, VAMP8",0.191114132640188,0.100726812682396,FALSE +"HCC44","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.28032,-0.821,0.646,8031,0.827,"ASAH1, DEGS1, NEU1, CERK, SMPD3, GALC",0.189767482004916,0.0824944904474534,FALSE +"HCC44","Input","KEGG_SPLICEOSOME",0.4694,1.41,0.123,3621,0.442,"HNRNPU, THOC1, TXNL4A, SNRPB, DDX46, PRPF31, U2AF1, SNRNP40, NCBP2, SLU7, THOC2, DHX38, SNRNP70, PRPF40A, U2AF2, SNRPA1, CDC40, SNRPF, THOC3, DDX42, PRPF4, LSM6, PRPF6, NCBP1, RBM22, RBM17, DHX16, DDX39B, SNRPD3, PRPF38A, DDX23, CHERP, SMNDC1, LSM2, ZMAT2, PRPF38B, SNRNP27, SF3B6, SRSF8, ACIN1, ALYREF, RBM25, PPIE, DHX8, SRSF2, SNRPG, PRPF3, SNW1, HNRNPC, SNRPC, EFTUD2, SNRPA, SART1, PRPF8, HNRNPM, LSM8, SNU13, TCERG1, SF3B4, PHF5A, SRSF1, RBM8A, SNRNP200, SNRPD1, SNRPD2, CWC15, EIF4A3, SF3B5, SNRPB2, PQBP1, SF3A3, SF3B2, U2SURP, SF3B3, PRPF19, SRSF7, CTNNBL1, SF3A1, SYF2, BCAS2, SRSF3, HNRNPK, PLRG1, WBP11, HNRNPA3, HNRNPA1, PPIL1, SF3A2, TRA2B, SRSF5, MAGOHB",0.910094888560602,0.354577730650908,FALSE +"HCC44","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.35956,1.12,0.285,1511,0.619,"PYGL, GCK, ENPP1, GUSB, GBE1, UGDH, UXS1",0.54515513999149,0.208309350979882,FALSE +"HCC44","Input","KEGG_STEROID_BIOSYNTHESIS",-0.72797,-2.14,0.00326,7448,0.231,"LSS, HSD17B7, DHCR24, CYP51A1, CEL, LIPA, MSMO1, SQLE, SC5D, FDFT1",2.48678239993206,0.636388020107856,TRUE +"HCC44","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.72218,-2.12,0.0115,7438,0.175,"CYP21A2, HSD17B7, AKR1C2, AKR1D1, AKR1C3, AKR1C1, STS, SULT2B1, CYP1A1, CYP11B1, HSD11B2",1.93930215964639,0.756961951313706,TRUE +"HCC44","Input","KEGG_SULFUR_METABOLISM",-0.79031,-2.32,0,8714,0.136,"SULT2B1, SUOX, SULT1A1",Inf,0.866461091629782,TRUE +"HCC44","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.44235,1.37,0.152,1123,0.416,"CD40, C3, ACTN1, ACTN4, ACTN2, SNRPB",0.818156412055227,0.380906669373257,FALSE +"HCC44","Input","KEGG_TASTE_TRANSDUCTION",-0.3859,-1.11,0.275,8469,0.676,"SCNN1A, ASIC2",0.560667306169737,0.170053304058364,FALSE +"HCC44","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.69095,-2.01,0.00666,7947,0.235,"IDI1, PMVK, HMGCR, MVK, HMGCS1",2.1765257708297,0.628932137728264,TRUE +"HCC44","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.25426,-0.741,0.763,7246,0.89,"CREBBP, MAPK1, SKP1, MAPK3, SMAD5, DCN, SMURF2, LTBP1, BMP6, INHBA, ACVR1, FST, THBS1",0.11747546204512,0.0506099933550872,FALSE +"HCC44","Input","KEGG_THYROID_CANCER",-0.53967,-1.6,0.053,7376,0.441,"MAPK1, RXRA, TCF7L2, TCF7L1, MAPK3, CCND1, CDH1, RXRG, TPM3, CTNNB1, NCOA4, TP53, LEF1",1.27572413039921,0.355561410532161,FALSE +"HCC44","Input","KEGG_TIGHT_JUNCTION",-0.389,-1.13,0.273,8009,0.702,"F11R, PRKCD, PATJ, TJP3, EPB41L1, CTNNA2, PARD6G, CTNNA1, LLGL2, SRC, CTNNB1, CGN, MPDZ, PRKCH, MYH14, MYH7B, EPB41L3, PRKCZ, CRB3, JAM3",0.563837352959244,0.153662887870195,FALSE +"HCC44","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.2275,-0.661,0.882,7099,0.959,"PIK3CA, AKT2, MAPK13, MAPK1, SPP1, MAPK3, MAPK12, TOLLIP, CASP8, FADD, STAT1, IL6, MAP2K6, IFNAR1, PIK3CD, TLR3",0.0545314148681803,0.0181813928293364,FALSE +"HCC44","Input","KEGG_TRYPTOPHAN_METABOLISM",0.28792,0.877,0.554,925,0.772,"KYNU, ALDH2, EHHADH, WARS2",0.25649023527157,0.112382699664264,FALSE +"HCC44","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.48482,-1.4,0.135,6047,0.583,"PKLR, MAPK10, PKM, IKBKB, PIK3R1, PIK3R2, IRS1, INSR, PIK3CA, MAPK1, MAPK3, HK1, PRKCD, PIK3CD, PRKCZ",0.869666231504994,0.234331445240986,FALSE +"HCC44","Input","KEGG_TYROSINE_METABOLISM",-0.42058,-1.25,0.208,7308,0.58,"ALDH3A1, LCMT1, MAOB, MAOA, TAT, DDC, ADH4, ADH7, ADH5",0.681936665037238,0.236572006437063,FALSE +"HCC44","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.45108,-1.34,0.132,7081,0.571,"NFATC2, PIK3CA, RAF1, PPP3CC, TEC, PRKCQ, AKT2, PAK4, MAPK13, MAPK1, VAV2, MAPK3, MAPK12, NFKBIE, GRB2, PTPN6, PLCG1, SOS1, VAV3, PDPK1, PTPRC, NCK2, PAK5, PAK6, GSK3B, PIK3CD, PPP3R1",0.87942606879415,0.243363891754152,FALSE +"HCC44","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.23239,-0.68,0.881,5967,0.944,"CUL5, UBA2, ANAPC7, UBE2D2, TRIM37, CUL4B, FBXW11, UBE2G1, DDB2, UBE2F, MAP3K1, UBE2J1, CUL3, UBE4B, FBXO2, NHLRC1, BTRC, UBA1, DDB1, SKP1, ANAPC4, COP1, FZR1, CDC20, UBE2R2, CUL7, HERC1, FBXW7, SMURF2, KEAP1, PIAS1, MGRN1, KLHL13, UBE2C",0.0550240915879521,0.025028005701931,FALSE +"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.28336,-0.827,0.692,7143,0.837,"IARS2, BCAT2",0.159893905543242,0.07727454200674,FALSE +"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.21887,-0.629,0.912,8659,0.974,"ACADS, ABAT, HMGCS1",0.0400051616715838,0.0114410431213845,FALSE +"HCC44","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.27061,-0.797,0.684,7010,0.842,"GNA13, PLCB2, GNAQ, RAF1, PRKCQ, ADCY9, PLCB3, MAPK1, ARHGEF12, MAPK3, GNA11, GNA12, KCNMA1, NPR2, ARHGEF11, PRKCD, CALM2, PRKCH, CALML3, PLCB4",0.164943898279884,0.0746879085003505,FALSE +"HCC44","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.39997,-1.18,0.262,6986,0.706,"DYNLL2, DYNLL1, ADCY9, RAB5B, RAB11A, AVP, AQP3, ARHGDIB",0.581698708680255,0.151195298948196,FALSE +"HCC44","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.30469,0.923,0.495,170,0.776,"RAC2, PTGS2, PLA2G4A, VEGFA",0.305394801066431,0.110138278741812,FALSE +"HCC44","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.25372,-0.747,0.772,6568,0.89,"KDELR3, ATP6V0D1, ATP6V1B2, ATP6V1A, ATP6V1E1, ATP6V1B1, ATP6V0A1, ATP6V1C2, ADCY9, ATP6V1H, ATP6V1F, ATP6V1C1, ATP6V1D, PLCG1, SLC12A2, PLCG2",0.112382699664264,0.0506099933550872,FALSE +"HCC44","Input","KEGG_VIRAL_MYOCARDITIS",0.46775,1.42,0.117,670,0.475,"RAC2, ITGB2, ICAM1, CD40, MYH11, MYH9, LAMA2, CD55",0.931814138253838,0.323306390375133,FALSE +"HCC44","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.31185,-0.901,0.528,6099,0.746,"DVL3, CTBP1, MAPK10, SMAD2, FBXW11, AXIN1, PPP3CB, ROCK1, PPP2R5C, CHD8, MAP3K7, PPP2CA, EP300, PPP2R5E, PLCB1, APC, WNT5A, PPP2R5A, BTRC, CSNK1E, PPP2R5D, FZD1, PLCB2, NFATC2, PPP2R5B, PPP3CC, CAMK2B, CREBBP, WNT11, PLCB3, LRP6, TCF7L2, SKP1, TCF7L1, VANGL1, CCND1, CAMK2D, FZD6, DAAM1, CSNK1A1, CTNNB1, GSK3B, RAC3, VANGL2, PPP3R1, TP53, PLCB4, LEF1",0.277366077466188,0.127261172527331,FALSE +"H1299","Input","KEGG_ABC_TRANSPORTERS",-0.27599,-0.873,0.599,8317,0.739,"ABCG2, ABCB6, ABCD3, ABCA2, ABCC2",0.222573177610689,0.131355561605174,FALSE +"H1299","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.24869,-0.785,0.737,6104,0.868,"PIK3R2, RUNX1, KRAS, NRAS, KIT, PIK3R3, BRAF, MAPK3, GRB2, SOS1, STAT3, HRAS, STAT5A, TCF7L2, RPS6KB2, PIM1, TCF7L1, PIK3CD, CCND1, LEF1, CEBPA",0.132532512140949,0.0614802748235081,FALSE +"H1299","Input","KEGG_ADHERENS_JUNCTION",-0.40719,-1.26,0.196,7299,0.361,"RAC1, PARD3, IGF1R, TCF7L2, WASF2, SRC, SORBS1, CREBBP, TCF7L1, EP300, LMO7, INSR, LEF1, ERBB2, PTPRM, ACTG1, BAIAP2, PTPN6, CTNNB1, CTNND1, NECTIN1, CTNNA1, CTNNA2, RAC2, CDH1",0.707743928643524,0.442492798094342,FALSE +"H1299","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.34377,-1.09,0.317,8606,0.481,"IRS2, CAMKK1, ACSL1, NFKBIA, RXRG, RXRA, ACSL5, PRKCQ",0.498940737782249,0.317854923626168,FALSE +"H1299","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.512,-1.61,0.0495,8299,0.19,"GFPT1, GLUL, CPS1, ABAT, ASS1, GLUD2",1.30539480106643,0.721246399047171,TRUE +"H1299","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.47784,-1.51,0.0708,7168,0.231,"ATP1A3, PDPK1, SFN, ATP1A1, SLC9A3R2, ATP1B3, ATP1A4, PIK3CD, ATP1B1, INSR, IRS2, HSD11B2",1.14996674231023,0.636388020107856,FALSE +"H1299","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.73163,-2.33,0.00368,8416,0.0412,"PLA2G12A, ACOX1, PLA2G4A, FADS2",2.43415218132648,1.38510278396687,TRUE +"H1299","Input","KEGG_ALZHEIMERS_DISEASE",0.18642,0.598,0.957,3800,1,"TNFRSF1A, PLCB4, CYC1, BAD, COX6C, NDUFA9, PSEN1, CYCS, NDUFB4, UQCRQ, MME, GAPDH, NDUFS2, CAPN2, CHP1, NDUFB7, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, NDUFA4, NDUFC2, ITPR1, PPP3CC, NDUFS3, UQCRFS1, CASP3, NDUFA5, NDUFA2, ATP5PO, NDUFA6, NDUFA10, COX4I1, COX6B1, ITPR2, ATP5PB, NDUFB10, NDUFB9, GRIN1, NCSTN, SDHD, COX5A, ADAM17, UQCRC2, FADD, APAF1, NDUFB2, CASP9, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB",0.0190880622231565,0,FALSE +"H1299","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.35339,1.12,0.292,1225,0.936,"RARS2, DARS2, YARS2, AARS2",0.534617148551582,0.0287241512618947,FALSE +"H1299","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.26716,-0.834,0.666,7688,0.799,"GMPPA, UGDH, GMDS, HK1, CYB5R1, GFPT1, PGM1, MPI, UXS1, GALT, PMM2, GALE",0.176525770829699,0.0974532206860086,FALSE +"H1299","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.34158,1.07,0.342,1049,0.872,"NEFH, TNFRSF1A, PRPH, PRPH2, MAP2K3, TOMM40, BAD, NEFM, DAXX, CYCS",0.465973893943865,0.0594835150674328,FALSE +"H1299","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.31939,-0.993,0.409,7289,0.579,"PSME2, CREB1, CTSB, B2M, PDIA3, PSME1, CANX, CD74, CALR, CTSS, IFI30",0.388276691992658,0.237321436272564,FALSE +"H1299","Input","KEGG_APOPTOSIS",0.20589,0.655,0.92,1231,1,"TNFRSF1A, RIPK1, TNFRSF10A, IRAK4, BIRC2, ENDOG, BAD, EXOG, CYCS, AKT1, IRAK1",0.0362121726544447,0,FALSE +"H1299","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.64437,-2.01,0.00737,8030,0.0878,"CBR1, GPX2, ALOX5, GGT1, PLA2G12A, GPX6, GPX7, CYP2J2, PTGS2, PTGES, PLA2G4A, EPHX2, GPX1",2.13253251214095,1.0565054840939,TRUE +"H1299","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.54637,-1.73,0.0414,7582,0.14,"MAOA, ALDH18A1, PYCR3, OAT, ALDH3A2, GAMT, CKMT2, GLUL, PYCR1, PYCR2, AGMAT, GATM, ARG2, P4HA2, P4HA1, ALDH2, ARG1, MAOB, CPS1, ALDH1B1, ASS1, GLUD2",1.3829996588791,0.853871964321762,TRUE +"H1299","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.37732,-1.21,0.183,8316,0.387,"ITGAV, LEF1, ACTG1, DSG2, ITGA7, PKP2, CTNNB1, ITGB4, GJA1, DSC2, CTNNA1, SGCD, CTNNA2, ITGB6",0.737548910269571,0.412289034981089,FALSE +"H1299","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.74763,-2.33,0,7164,0.0412,"ALDH9A1, UGDH, ALDH3A2, ALDH2, ALDH1B1",Inf,1.38510278396687,TRUE +"H1299","Input","KEGG_AXON_GUIDANCE",-0.4094,-1.29,0.17,8174,0.343,"PLXNB1, DPYSL2, PLXNB2, SEMA7A, SEMA4D, EPHB2, SEMA3A, EFNB2, EPHA1, UNC5B, SEMA6A, EPHA4, L1CAM, RAC2, ABLIM1, ABLIM3, PLXNA2, ABLIM2",0.769551078621726,0.464705879957229,FALSE +"H1299","Input","KEGG_BASAL_CELL_CARCINOMA",-0.64483,-2.03,0.00929,7556,0.0914,"TCF7L2, FZD7, GSK3B, APC, TCF7L1, SHH, LEF1, WNT16, CTNNB1, SUFU, TP53, WNT11",2.03198428600636,1.03905380426617,TRUE +"H1299","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.23949,0.769,0.771,3786,1,"TAF2, TBP, GTF2I, TAF9B, GTF2A1, GTF2H4, GTF2A2, TAF6, TAF1, TAF5, TAF13",0.112945621949043,0,FALSE +"H1299","Input","KEGG_BASE_EXCISION_REPAIR",-0.37405,-1.16,0.26,7169,0.407,"SMUG1, XRCC1, FEN1, NTHL1, LIG1, APEX1, MPG, APEX2, LIG3, PARP1, TDG",0.585026652029182,0.39040559077478,FALSE +"H1299","Input","KEGG_BETA_ALANINE_METABOLISM",-0.58082,-1.83,0.0162,7164,0.127,"ALDH9A1, SRM, EHHADH, HIBCH, ALDH3A2, ALDH2, ABAT, ALDH1B1",1.79048498545737,0.896196279044043,TRUE +"H1299","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.28374,0.881,0.546,786,1,"ELOVL2, ELOVL5, HACD1, ACOX3",0.262807357295263,0,FALSE +"H1299","Input","KEGG_BLADDER_CANCER",-0.35677,-1.11,0.302,8433,0.463,"CCND1, THBS1, ERBB2, TP53, CDH1",0.519993057042849,0.334419008982047,FALSE +"H1299","Input","KEGG_BUTANOATE_METABOLISM",-0.60337,-1.89,0.0231,8426,0.119,"HMGCS2, BDH2, HMGCS1, ACADS, BDH1, ALDH2, ABAT, ALDH1B1, ACSM3",1.63638802010786,0.924453038607469,TRUE +"H1299","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.31263,-0.996,0.405,7871,0.581,"GSK3B, PIK3AP1, PIK3CD, BTK, PTPN6, SYK, NFKBIA, CD81, INPP5D, RAC2",0.392544976785331,0.235823867609669,FALSE +"H1299","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.33568,-1.03,0.366,6674,0.556,"PPP3CB, CALML3, PHKA2, GNAS, ERBB4, CAMK2D, CAMK2G, ATP2B1, ADCY9, GNA11, ATP2A3, GNAQ, SLC25A4, PRKACB, ITPKB, LTB4R2, PTK2B, P2RX4, ATP2B2, ATP2B4, ERBB2, BST1, ERBB3, MYLK, PLCB1, TNNC1, CACNA1A, TNNC2",0.436518914605589,0.254925208417942,FALSE +"H1299","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.36738,1.18,0.241,755,0.887,"TPM2, SLC8A1, CACNA2D1, SLC9A6, CYC1, COX6C",0.617982957425132,0.0520763801682736,FALSE +"H1299","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.53518,-1.7,0.0352,8105,0.149,"CD58, NEO1, VCAM1, CD274, ITGAV, ITGB2, PTPRM, F11R, CNTN1, SDC3, NECTIN1, CLDN3, SDC1, CLDN4, CLDN6, ALCAM, L1CAM, CD276, SDC2, CDH1, NRCAM, CD99, CADM1, CDH15, CDH3, ICAM2, CLDN7",1.45345733652187,0.826813731587726,TRUE +"H1299","Input","KEGG_CELL_CYCLE",0.33724,1.09,0.317,3160,0.864,"TGFB1, ESPL1, TTK, CDK6, CDK1, BUB1, CCNB1, PRKDC, ANAPC4, ORC3, ANAPC5, ORC4, CDC20, DBF4, CDC45, ORC5, CDC16, YWHAZ, CCNB2, ORC1, MYC, CHEK1, CDC27, ORC2, ANAPC1, PLK1, CDK7, ANAPC7, CDC23, MAD2L2, MCM7, SMC3, ANAPC2, YWHAB, MCM2, SMC1A, MAD1L1, YWHAQ, ANAPC10, CDC25C, SMC1B, CUL1, BUB1B, MCM6, MCM4, MCM5, RB1, SMAD3, TGFB2",0.498940737782249,0.0634862575211067,FALSE +"H1299","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.31113,-0.974,0.424,6212,0.593,"KRAS, NRAS, PIK3R3, BRAF, CCR4, GNB2, MAPK3, GNG2, RHOA, ARRB2, STAT2, GRB2, GNB1, GNB4, SOS1, STAT3, CCL13, HRAS, WASL, ADCY9, CCL15, RAC1, PARD3, GNG10, VAV2, PREX1, PRKACB, GSK3B, STAT1, GNB3, PIK3CD, ELMO1, PTK2B, GRK2, PRKCD, NFKBIA, ADCY5, PLCB1, CCL20, RAC2, ARRB1",0.372634143407267,0.226945306635737,FALSE +"H1299","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.19833,0.636,0.91,1929,1,"TGFB1, CDK6, CBL, BAD, AKT1, MYC, MECOM, SHC1, AKT2, CRK, AKT3",0.0409586076789064,0,FALSE +"H1299","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.36967,-1.17,0.243,7037,0.4,"IDH3G, DLAT, SUCLA2, ACO2, ACLY, PCK2, SUCLG2, MDH1, SUCLG1, PC, IDH1, IDH2",0.614393726401688,0.397940008672038,FALSE +"H1299","Input","KEGG_COLORECTAL_CANCER",-0.20836,-0.657,0.919,7871,0.973,"GSK3B, APC, TCF7L1, PIK3CD, CCND1, LEF1, CTNNB1, TP53, RAC2",0.0366844886138887,0.0118871597316481,FALSE +"H1299","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.43013,-1.36,0.133,7894,0.304,"F8, SERPING1, C5, PROC, CD46, FGA, FGG, TFPI, FGB, PLG, F3, PROS1, SERPINA1, CD55, SERPINF2, A2M, C4A, SERPINC1",0.876148359032914,0.517126416391246,FALSE +"H1299","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.26869,0.85,0.592,1334,1,"LDHB, CBS, DNMT1, SDS, CDO1, GOT1, SMS",0.22767829327708,0,FALSE +"H1299","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.21322,0.683,0.866,605,1,"TGFB1, TNFRSF1A, CD70, TNFRSF10A, OSMR",0.0624821079826534,0,FALSE +"H1299","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.30925,-1.02,0.38,8812,0.567,"NFKBIA, IL6, TREX1, IL18, PYCARD",0.42021640338319,0.246416941107093,FALSE +"H1299","Input","KEGG_DILATED_CARDIOMYOPATHY",0.39562,1.3,0.16,211,0.779,"TGFB1, ITGA4, TPM2, SLC8A1, ITGA3, DES, CACNA2D1",0.795880017344075,0.108462542327436,FALSE +"H1299","Input","KEGG_DNA_REPLICATION",0.41963,1.32,0.15,3133,0.802,"PRIM1, PRIM2, POLA1, POLE, POLA2, POLE2, DNA2, RFC3, POLE3, RFC2, RFC5, RFC4, MCM7, MCM2, RNASEH2A, MCM6, MCM4, MCM5, RFC1",0.823908740944319,0.0958256317158365,FALSE +"H1299","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.26076,0.831,0.653,6901,1,"ETS1, EGFR, NOTCH2, MAPK1, MAP2K1, ETV6, NOTCH3, NOTCH1, KRAS, MAPK3, GRB2, SOS1",0.185086818724926,0,FALSE +"H1299","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.61305,-1.96,0.0164,8247,0.108,"GSTM3, CYP3A5, ALDH3A1, MGST3, GSTM4, GSTP1, MAOB, GSTM1, ALDH1A3, MGST1, GSTZ1, GSTT2",1.7851561519523,0.96657624451305,TRUE +"H1299","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.33138,-1.04,0.358,8546,0.553,"CYP3A5, CES1, CES2, CDA",0.446116973356126,0.257274868695302,FALSE +"H1299","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.54823,-1.7,0.0568,8277,0.149,"THBS4, COL2A1, ITGAV, THBS1, LAMA3, LAMA4, LAMA1, HSPG2, COL6A3, ITGA7, VTN, SDC3, ITGB4, COL5A1, LAMA5, COL1A2, LAMB1, TNC, COL1A1, COL4A1, COL3A1, AGRN, COL5A2, FN1, SDC1, SDC2, ITGB6, COL4A2",1.24565166428898,0.826813731587726,FALSE +"H1299","Input","KEGG_ENDOCYTOSIS",-0.24244,-0.762,0.759,6194,0.894,"IQSEC1, KIT, HSPA2, ARAP1, ACAP3, IQSEC2, CHMP3, NEDD4L, FGFR3, ARRB2, EHD3, ARFGAP2, PIP5K1C, AP2S1, PRKCI, AGAP2, ERBB4, RAB11FIP5, CHMP2A, CLTCL1, SH3GL2, PIP4K2B, SH3GLB2, SMAP2, HRAS, EPS15, PARD3, STAM, AGAP1, IGF1R, CHMP4A, CHMP4B, STAMBP, RAB22A, RAB11FIP4, AP2A1, FGFR4, RAB5C, CBLB, SRC, LDLRAP1, CHMP4C, CHMP2B, GIT1, DAB2, DNAJC6, ARF6, EPN1, PARD6G, GRK2, ERBB3, PARD6B, DNM1, RAB11FIP1, ARRB1",0.11975822410452,0.0486624812040823,FALSE +"H1299","Input","KEGG_ENDOMETRIAL_CANCER",-0.42658,-1.34,0.122,7871,0.313,"GSK3B, APC, TCF7L1, PIK3CD, CCND1, LEF1, ERBB2, CTNNB1, CTNNA1, CTNNA2, TP53, CDH1",0.913640169325252,0.504455662453552,FALSE +"H1299","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.22248,-0.689,0.837,6283,0.955,"ADAM10, ATP6V0A1, ATP6V1G1, ATP6V0C, ATP6AP1, PLCG2, ATP6V1E1, MAPK8, TJP1, ATP6V1F, RAC1, ATP6V1C2, ATP6V0D1, SRC, GIT1, ATP6V0D2, F11R, NFKBIA, MAPK13",0.07727454200674,0.0199966284162537,FALSE +"H1299","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.18053,-0.572,0.971,6212,0.989,"KRAS, NRAS, PIK3R3, BRAF, MAPK3, PLCG2, MAPK8, GRB2, SOS1, MAP2K7, ERBB4, CAMK2D, CAMK2G, HRAS, NCK2, STAT5A, GAB1, ABL2, RPS6KB2, CBLB, GSK3B, SRC, EREG, PIK3CD, ERBB2, ERBB3, AREG",0.0127807700919951,0.0048037084028206,FALSE +"H1299","Input","KEGG_ETHER_LIPID_METABOLISM",-0.50311,-1.6,0.0569,8097,0.192,"PAFAH2, PLA2G12A, LPCAT2, PLA2G4A, PLPP3",1.24488773360493,0.71669877129645,FALSE +"H1299","Input","KEGG_FATTY_ACID_METABOLISM",-0.38803,-1.21,0.225,7905,0.387,"ALDH3A2, CPT2, GCDH, ACOX1, ACAA1, ACADS, ACSL1, ALDH2, ALDH1B1, ACSL5",0.647817481888638,0.412289034981089,FALSE +"H1299","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.43435,-1.36,0.121,8251,0.304,"PIK3CD, PLA2G12A, BTK, SYK, PRKCD, PLA2G4A, MAPK13, INPP5D, RAC2, MAP2K6",0.91721462968355,0.517126416391246,FALSE +"H1299","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.36011,-1.14,0.249,8251,0.427,"PIK3CD, ARF6, MARCKSL1, MARCKS, DNM1, SYK, PRKCD, SCIN, PLA2G4A, PLPP3, AMPH, INPP5D, RAC2",0.603800652904264,0.369572124974976,FALSE +"H1299","Input","KEGG_FOCAL_ADHESION",-0.30779,-0.965,0.463,8251,0.603,"PIK3CD, THBS4, COL2A1, ITGAV, ARHGAP5, MYL9, FLNB, CCND1, THBS1, LAMA3, LAMA4, ERBB2, LAMA1, ACTG1, MYLK, COL6A3, ITGA7, VTN, CTNNB1, ITGB4, COL5A1, LAMA5, COL1A2, LAMB1, TNC, COL1A1, COL4A1, COL3A1, COL5A2, FN1, ITGB6, RAC2, COL4A2",0.334419008982047,0.219682687859849,FALSE +"H1299","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.55745,-1.74,0.0364,8870,0.14,"QDPR, ALPI, ALPP",1.43889861635094,0.853871964321762,TRUE +"H1299","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.55361,-1.75,0.0407,6901,0.144,"PFKL, PFKM, GMPPB, ALDOA, PFKFB3, PFKFB2, GMPPA, AKR1B1, GMDS, HK1, KHK, MPI, PFKFB4, ALDOC, PMM2",1.39040559077478,0.84163750790475,TRUE +"H1299","Input","KEGG_GALACTOSE_METABOLISM",-0.54319,-1.69,0.0522,6901,0.15,"PFKL, PFKM, GANC, AKR1B1, HK1, GLB1, PGM1, GALT, GALE, GAA, B4GALT1",1.28232949699774,0.823908740944319,FALSE +"H1299","Input","KEGG_GAP_JUNCTION",-0.19341,-0.595,0.965,6756,1,"GRB2, GNAS, SOS1, TJP1, TUBAL3, HRAS, ADCY9, GUCY1A1, GNA11, GNAQ, PRKACB, SRC, ADCY5, GJA1, PLCB1, TUBA4A",0.0154726866562074,0,FALSE +"H1299","Input","KEGG_GLIOMA",-0.18458,-0.575,0.971,6104,0.995,"PIK3R2, KRAS, NRAS, PIK3R3, BRAF, MAPK3, PLCG2, CALML3, GRB2, SOS1, CAMK2D, CAMK2G, HRAS, IGF1R, CDK4, PIK3CD, CCND1, TP53",0.0127807700919951,0.00217691925427455,FALSE +"H1299","Input","KEGG_GLUTATHIONE_METABOLISM",-0.55513,-1.79,0.0248,8136,0.132,"G6PD, GPX2, GSTM3, GGT1, GPX6, GPX7, GSR, MGST3, GSTM4, GSTP1, IDH1, GSTM1, MGST1, GSTZ1, GSTT2, IDH2, GPX1",1.60554831917378,0.87942606879415,TRUE +"H1299","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.42507,-1.33,0.149,6839,0.318,"DGKA, AGPAT2, TKFC, ALDH9A1, CEL, DGKD, DGKZ, AKR1B1, ALDH3A2, LIPG, ALDH2, MGLL, PLPP3, LIPC, LPL, AKR1A1, ALDH1B1",0.826813731587726,0.497572880015567,FALSE +"H1299","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.27765,-0.861,0.597,6836,0.754,"PTDSS1, DGKA, MBOAT7, AGPAT2, CHKB, CDS1, GPD1L, LYPLA2, CDIPT, CDS2, CHKA, DGKD, DGKZ, LPGAT1, PEMT, GNPAT, PLA2G12A, LPCAT2, PLA2G4A, PLPP3",0.224025668870631,0.122628654130226,FALSE +"H1299","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.38232,-1.2,0.226,6692,0.384,"PSPH, SHMT1, SHMT2, AGXT, MAOA, GCAT, PHGDH, SRR, GAMT, SARDH, CTH, GATM, CHDH, MAOB",0.645891560852599,0.415668775632469,FALSE +"H1299","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.39076,-1.2,0.234,6901,0.384,"PFKL, PFKM, ACSS2, DLAT, ALDH9A1, BPGM, ALDOA, GALM, PGAM2, PCK2, ALDH3A2, HK1, LDHA, PGM1, ALDH3A1, ACSS1, ALDOC, ALDH2, ALDH1A3, AKR1A1, ALDH1B1",0.630784142589857,0.415668775632469,FALSE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.4068,-1.25,0.183,7049,0.356,"CHST11, B3GAT3, CHPF, CHST13, CHST12, XYLT1",0.737548910269571,0.448550002027125,FALSE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.40611,-1.28,0.172,8371,0.348,"GLCE, XYLT1, HS6ST2",0.764471553092451,0.458420756053419,FALSE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.76407,-2.35,0.00189,7570,0.092,"B4GALT3, B4GAT1, B3GNT2, ST3GAL1, B4GALT4, B4GALT1",2.72353819582676,1.03621217265444,TRUE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.33106,-1.03,0.374,7666,0.556,"IDS, IDUA, GLB1, HGSNAT, NAGLU",0.42712839779952,0.254925208417942,FALSE +"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.41618,-1.31,0.14,8864,0.334,"ST3GAL1",0.853871964321762,0.476253533188435,FALSE +"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.74034,-2.34,0.0075,7570,0.0652,"B4GALT3, B4GAT1, B3GNT3, B3GNT2, ST3GAL6, ST3GAL4, B4GALT4, B4GALT1",2.1249387366083,1.18575240426808,TRUE +"H1299","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.19378,-0.609,0.943,7000,1,"PIGO, PIGU, PIGS, PIGQ",0.0254883072626717,0,FALSE +"H1299","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.4821,1.57,0.0641,1618,0.587,"MTHFD1L, MTHFD2L, HYI, MTHFD2, MDH2, CS",1.19314197048118,0.231361898752386,FALSE +"H1299","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.31871,-1,0.412,6707,0.58,"CALML3, MAPK8, GRB2, GNAS, SOS1, MAP2K7, CAMK2D, CAMK2G, HRAS, ADCY9, GNA11, GNAQ, PRKACB, MAP3K1, SRC, MMP14, PTK2B, PLA2G12A, PRKCD, ADCY5, PLCB1, PLA2G4A, MAPK13, MAP2K6",0.385102783966865,0.236572006437063,FALSE +"H1299","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.64355,-2.07,0.00183,7408,0.108,"CSNK1E, PRKACB, GSK3B, SHH, WNT16, SUFU, WNT11",2.73754891026957,0.96657624451305,TRUE +"H1299","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.4814,1.54,0.0675,1229,0.558,"ITGA4, ITGA3, CD44, ANPEP, CD59, ITGA6, ITGA5, MME, CD9",1.17069622716898,0.253365801062421,FALSE +"H1299","Input","KEGG_HISTIDINE_METABOLISM",-0.58082,-1.86,0.0208,7582,0.122,"MAOA, ALDH3A2, HNMT, DDC, ALDH3A1, ALDH2, MAOB, ALDH1A3, ALDH1B1",1.68193666503724,0.913640169325252,TRUE +"H1299","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.51928,1.67,0.0346,1324,0.497,"RAD51C, RAD52, SEM1, TOP3A, BLM, RAD50, NBN, MRE11",1.46092390120722,0.303643611266668,FALSE +"H1299","Input","KEGG_HUNTINGTONS_DISEASE",0.16839,0.535,0.98,4015,1,"PLCB4, CYC1, COX6C, NDUFA9, POLR2B, CYCS, NDUFB4, UQCRQ, TBP, NDUFS2, DLG4, POLR2K, NDUFB7, POLR2A, RCOR1, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, TGM2, TFAM, POLR2G, HIP1, DCTN1, NDUFA4, NDUFC2, ITPR1, GRM5, NDUFS3, UQCRFS1, CASP3, NDUFA5, NDUFA2, DCTN2, ATP5PO, NDUFA6, NDUFA10, COX4I1, COX6B1, POLR2E, POLR2I, ATP5PB, NDUFB10, NDUFB9, GRIN1, SDHD, COX5A, POLR2J, UQCRC2, POLR2C, SIN3A, IFT57, HDAC2, APAF1, NDUFB2, CASP9, CLTC, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB, SLC25A31, NDUFV1, ATP5F1A, HTT, DCTN4, UQCRH, VDAC2, ATP5F1C",0.00877392430750515,0,FALSE +"H1299","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.38084,1.22,0.221,211,0.912,"TGFB1, ITGA4, TPM2, SLC8A1, ITGA3, DES, CACNA2D1",0.655607726314889,0.0400051616715838,FALSE +"H1299","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.30975,1,0.384,999,0.976,"ISYNA1, IMPA1, PLCB4, SYNJ2, SYNJ1, INPP5K, INPP4B",0.415668775632469,0.0105501823333082,FALSE +"H1299","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.21631,-0.676,0.878,5890,0.957,"CALM2, CRKL, PPP1CB, PPP1R3D, IKBKB, PTPRF, PIK3R2, PHKG2, KRAS, NRAS, HK2, PHKB, PIK3R3, PRKAR2B, HK3, BRAF, PYGB, MAPK3, CALML3, MAPK8, PRKCI, PHKA2, GRB2, SOS1, PRKAR1A, PRKAR1B, HRAS, PYGL, EXOC7, PDPK1, FLOT1, PDE3A, PCK2, RPS6KB2, CBLB, PRKACB, GSK3B, MKNK1, FOXO1, HK1, SORBS1, FLOT2, PRKAA2, PIK3CD, INSR, IRS2, GYS1, INPP5D",0.0565054840938974,0.0190880622231565,FALSE +"H1299","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.59836,1.87,0.0348,49,1,"TGFB1, ITGA4",1.45842075605342,0,FALSE +"H1299","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.22286,-0.716,0.847,6637,0.923,"STAT2, LIFR, GRB2, SOS1, STAT3, IFNAR1, STAM, STAT5A, PIM1, CBLB, STAT1, CREBBP, IL13RA1, EP300, PIK3CD, CCND1, IRF9, PTPN6, STAT6, IL6",0.0721165896692931,0.0347982989740879,FALSE +"H1299","Input","KEGG_LEISHMANIA_INFECTION",0.30283,0.956,0.432,536,1,"TGFB1, ITGA4, JUN, MAP3K7, IRAK4",0.364516253185088,0,FALSE +"H1299","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.3717,-1.17,0.245,8232,0.4,"VCAM1, PIK3CD, ARHGAP5, MYL9, PTK2B, ITGB2, F11R, ACTG1, CTNNB1, CTNND1, CLDN3, CTNNA1, CLDN4, CTNNA2, CLDN6, MAPK13, RAC2, CD99, CLDN7",0.610833915635468,0.397940008672038,FALSE +"H1299","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.65603,-2.04,0.00962,7164,0.104,"ALDH9A1, EHHADH, ALDH3A2, ALDH2, ALDH1B1",2.01682492796219,0.98296666070122,TRUE +"H1299","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.79212,-2.51,0.0018,8416,0.0409,"PLA2G12A, CYP3A5, CYP2J2, PLA2G4A",2.74472749489669,1.38827669199266,TRUE +"H1299","Input","KEGG_LONG_TERM_DEPRESSION",-0.31337,-1.01,0.396,6212,0.57,"KRAS, NRAS, BRAF, PLA2G12B, MAPK3, RYR1, GUCY1B1, GNAS, HRAS, GUCY1A1, GNA11, IGF1R, GNAQ, GNA13, PLA2G12A, GNAO1, PLCB1, CACNA1A, PLA2G4A",0.402304814074488,0.244125144327509,FALSE +"H1299","Input","KEGG_LONG_TERM_POTENTIATION",0.15912,0.522,0.998,199,1,"ATF4, PLCB4",0.000869458712628891,0,FALSE +"H1299","Input","KEGG_LYSINE_DEGRADATION",-0.19376,-0.593,0.968,7905,1,"ALDH3A2, GCDH, PLOD1, PLOD2, ALDH2, ALDH1B1",0.0141246426916063,0,FALSE +"H1299","Input","KEGG_LYSOSOME",-0.39391,-1.2,0.199,7548,0.384,"LAMP1, CTSB, IDS, IDUA, GNPTAB, ATP6V0D1, PPT1, GNPTG, GGA2, SORT1, GM2A, AP1M2, AP3S2, GLB1, CTSZ, LAMP2, GBA, NAPSA, ATP6V0D2, SUMF1, ABCA2, FUCA1, ENTPD4, CTSS, SCARB2, HGSNAT, SLC11A2, ASAH1, NAGLU, GAA, ARSA, CTSH",0.701146923590293,0.415668775632469,FALSE +"H1299","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.26656,0.853,0.608,445,1,"TGFB1, FLNC, RELB, FGF13, FGF2, ATF4, TNFRSF1A, NFKB2, CACNA2D1, FGFR1, MAP2K3, JUN, MAP3K7",0.216096420727265,0,FALSE +"H1299","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.63279,-2.01,0.0183,7212,0.0878,"HES1, HNF1B, MNX1, IAPP, NEUROD1, HNF1A, HNF4A, FOXA2",1.73754891026957,1.0565054840939,TRUE +"H1299","Input","KEGG_MELANOGENESIS",-0.50213,-1.59,0.0626,7032,0.194,"CAMK2D, CAMK2G, HRAS, ADCY9, CREB1, ASIP, TCF7L2, GNAQ, FZD7, PRKACB, GSK3B, CREBBP, KITLG, TCF7L1, EP300, LEF1, GNAO1, DCT, WNT16, CREB3L2, CTNNB1, ADCY5, MITF, TYRP1, PLCB1, WNT11",1.20342566678957,0.712198270069774,FALSE +"H1299","Input","KEGG_MELANOMA",0.32989,1.05,0.351,235,0.881,"FGF13, FGF2, CDK6, FGFR1",0.454692883534176,0.0550240915879521,FALSE +"H1299","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.59808,-1.88,0.00954,8139,0.118,"CYP1B1, GSTM3, CYP3A5, ALDH3A1, MGST3, GSTM4, GSTP1, CYP2S1, EPHX1, GSTM1, ALDH1A3, MGST1, GSTZ1, GSTT2",2.0204516252959,0.928117992693875,TRUE +"H1299","Input","KEGG_MISMATCH_REPAIR",0.25847,0.823,0.646,3817,1,"RFC3, RFC2, RFC5, PMS2, RFC4, MSH3, RFC1, MSH6, RPA2, SSBP1, MSH2",0.189767482004916,0,FALSE +"H1299","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.15967,0.512,0.995,2192,1,"ULK1, AKT1, ULK3, RICTOR, RPS6KB1, AKT2, AKT3, RPTOR, RPS6, PRKAA1, MTOR",0.00217691925427455,0,FALSE +"H1299","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.23437,-0.736,0.781,6099,0.907,"PPP3CA, PIK3R2, KRAS, NRAS, IFNAR2, PIK3R3, BRAF, TNFRSF10B, MAPK3, BID, PLCG2, PPP3CB, GRB2, TNFRSF10D, SOS1, IFNAR1, RAET1L, ULBP2, HRAS, RAC1, VAV2, PIK3CD, LCK, PTK2B, ITGB2, PTPN6, SYK, RAC2, ICAM2",0.1073489661227,0.0423927129399047,FALSE +"H1299","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.23196,-0.722,0.804,6550,0.921,"F2, TSPO, PARD3, LTB4R2, PLG, P2RX4",0.0947439512515487,0.0357403698031511,FALSE +"H1299","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.21115,-0.676,0.866,6212,0.957,"KRAS, NRAS, MAP3K3, PIK3R3, RPS6KA6, ARHGDIA, BRAF, MAPK3, RHOA, PLCG2, RPS6KA3, YWHAH, CALML3, MAPK8, BAX, GRB2, SOS1, MAP2K7, CAMK2D, CAMK2G, HRAS, MAP3K5, RAC1, RPS6KA5, PDPK1, GAB1, MAPKAPK2, RPS6KA4, MAP3K1, GSK3B, SORT1, RPS6KA2, ARHGDIB, PIK3CD, RPS6KA1, IRS2, PRKCD, NFKBIA, MAPK13, NGFR, TP53",0.0624821079826534,0.0190880622231565,FALSE +"H1299","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.50481,-1.55,0.0794,8445,0.206,"PNP, BST1, NNMT, NNT, NUDT12, QPRT",1.1001794975729,0.686132779630847,FALSE +"H1299","Input","KEGG_NITROGEN_METABOLISM",-0.43691,-1.35,0.118,7711,0.309,"CA2, CA5B, CA12, GLUL, CTH, CPS1, GLUD2",0.928117992693875,0.510041520575165,FALSE +"H1299","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.28592,-0.879,0.576,8812,0.734,"NFKBIA, IL6, IL18, MAPK13, PYCARD",0.239577516576788,0.134303940083929,FALSE +"H1299","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.4647,1.51,0.0734,1324,0.543,"PRKDC, RAD50, MRE11",1.13430394008393,0.265200170411153,FALSE +"H1299","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.25345,-0.783,0.718,8251,0.864,"PIK3CD, CCND1, ERBB2, FHIT, RXRG, RXRA, TP53",0.1438755557577,0.0634862575211067,FALSE +"H1299","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.28057,-0.888,0.556,7134,0.732,"NCOR2, MAML2, HES1, CTBP2, CREBBP, EP300, DTX3L, JAG1, JAG2",0.254925208417942,0.135488918941608,FALSE +"H1299","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.21893,0.719,0.819,2833,1,"POLE, POLE2, RFC3, POLE3, RFC2, RFC5, CDK7, RFC4, ERCC2, XPA, GTF2H4, ERCC3",0.0867160982395816,0,FALSE +"H1299","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.34236,-1.1,0.304,7512,0.472,"MAN1B1, B4GALT3, MAN1A2, ALG12, ALG13, MGAT5, B4GALT1, MGAT4A, ST6GAL1",0.517126416391246,0.326058001365912,FALSE +"H1299","Input","KEGG_OLFACTORY_TRANSDUCTION",0.224,0.728,0.833,1062,1,"PDE1C, CNGB1",0.0793549985932124,0,FALSE +"H1299","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.35284,1.12,0.294,2549,0.936,"MTHFD1L, MTHFD2L, MTHFD2, TYMS, GART, MTHFD1",0.531652669587843,0.0287241512618947,FALSE +"H1299","Input","KEGG_OOCYTE_MEIOSIS",0.3392,1.11,0.294,2416,0.909,"STAG3, ESPL1, CDK1, BUB1, CCNB1, ANAPC4, PPP2R5E, PPP2R5D, PPP2R5C, ANAPC5, CDC20, PPP2R1B, SGO1, CDC16, YWHAZ, CCNB2, CDC27, CHP1, ANAPC1, PLK1, PPP1CC, ANAPC7, PPP1CA, CDC23, MAD2L2, SLK, SMC3, ANAPC2, ITPR1, PPP3CC, YWHAB",0.531652669587843,0.0414361167780325,FALSE +"H1299","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.44465,-1.4,0.112,7614,0.287,"FUCA2, GLB1, GBA, FUCA1",0.950781977329818,0.542118103266008,FALSE +"H1299","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.22338,0.71,0.848,3800,1,"CYC1, COX15, COX6C, NDUFA9, NDUFB4, UQCRQ, NDUFS2, NDUFB7, NDUFA11, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, COX11, NDUFA4, NDUFC2, NDUFS3, UQCRFS1, ATP6V0A2, NDUFA5, NDUFA2, ATP6V1D, ATP5PO, ATP6V1C1, NDUFA6, NDUFA10, COX4I1, COX6B1, ATP5PB, NDUFB10, NDUFB9, SDHD, COX5A, ATP5MG, UQCRC2, NDUFB2, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB",0.0716041477432862,0,FALSE +"H1299","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.71766,-2.28,0,7307,0.0467,"GALNT14, GALNT15, GALNT13, GALNT7, B3GNT6, GALNT1, GALNT6, B4GALT5, GALNT2, GALNT5, ST3GAL1, GALNT3, GALNT12",Inf,1.33068311943389,TRUE +"H1299","Input","KEGG_P53_SIGNALING_PATHWAY",0.24681,0.799,0.674,1843,1,"SERPINE1, STEAP3, CDK6, CDK1, CCNB1, CD82, CYCS, CCNB2, CHEK1, RRM2B, RRM2, GTSE1",0.17134010346468,0,FALSE +"H1299","Input","KEGG_PANCREATIC_CANCER",-0.19446,-0.61,0.935,7916,1,"CDK4, STAT1, ARHGEF6, PIK3CD, CCND1, ERBB2, TP53, RAC2",0.0291883891274822,0,FALSE +"H1299","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.41145,-1.29,0.155,6012,0.343,"COASY, PPCS, PANK3, PANK2, BCAT2, ENPP1, PANK1",0.809668301829709,0.464705879957229,FALSE +"H1299","Input","KEGG_PARKINSONS_DISEASE",0.27221,0.844,0.6,4015,1,"UCHL1, CYC1, COX6C, HTRA2, NDUFA9, CYCS, NDUFB4, UQCRQ, NDUFS2, UBE2G1, NDUFB7, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, NDUFA4, NDUFC2, NDUFS3, UQCRFS1, CASP3, NDUFA5, NDUFA2, ATP5PO, NDUFA6, NDUFA10, COX4I1, UBE2J2, COX6B1, ATP5PB, NDUFB10, NDUFB9, SDHD, COX5A, UQCRC2, APAF1, NDUFB2, CASP9, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB, SLC25A31, NDUFV1, ATP5F1A, UQCRH, VDAC2, ATP5F1C",0.221848749616356,0,FALSE +"H1299","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.2403,-0.76,0.76,8587,0.89,"ACTG1, CTNNB1, TUBA4A, CDH1",0.119186407719209,0.0506099933550872,FALSE +"H1299","Input","KEGG_PATHWAYS_IN_CANCER",-0.28055,-0.883,0.568,7701,0.735,"LAMB3, LAMC1, CBLB, FZD7, ARNT, EGLN1, GSK3B, CDK4, STAT1, FOXO1, CREBBP, APC, KITLG, TCF7L1, TRAF5, SHH, EP300, PIK3CD, SKP2, ITGAV, CCND1, LAMA3, LAMA4, NCOA4, LEF1, ERBB2, LAMA1, PTGS2, WNT16, AR, CTNNB1, NFKBIA, LAMA5, SUFU, MITF, GSTP1, CEBPA, IL6, LAMB1, COL4A1, CTNNA1, RXRG, TRAF4, FN1, CTNNA2, RXRA, TP53, RAC2, COL4A2, CDH1, WNT11",0.245651664288981,0.133712660915805,FALSE +"H1299","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.63939,-2.03,0.00591,5961,0.0914,"UGP2, GUSB, RPE, XYLB, UGDH, AKR1B1, CRYL1, DCXR",2.22841251911874,1.03905380426617,TRUE +"H1299","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.49597,-1.57,0.0618,6410,0.203,"PRPS1, PRPS1L1, DERA, PFKL, PFKM, ALDOA, H6PD, PGD, G6PD, TALDO1, TKT, PGM1, ALDOC",1.20901152491118,0.692503962086787,FALSE +"H1299","Input","KEGG_PEROXISOME",-0.44561,-1.4,0.121,7248,0.287,"GSTK1, AGXT, EHHADH, MVK, SCP2, PEX13, HSD17B4, GNPAT, DECR2, AMACR, PHYH, ABCD3, PECR, ACOX1, ACAA1, ACSL1, DHRS4, IDH1, NUDT12, EPHX2, ACSL5, IDH2",0.91721462968355,0.542118103266008,FALSE +"H1299","Input","KEGG_PHENYLALANINE_METABOLISM",-0.60771,-1.92,0.0183,6665,0.108,"ALDH3B1, PRDX6, PAH, MIF, MAOA, DDC, ALDH3A1, MAOB, ALDH1A3",1.73754891026957,0.96657624451305,TRUE +"H1299","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.21024,0.681,0.879,999,1,"DGKE, IMPA1, PLCB4, SYNJ2, SYNJ1, INPP5K, INPP4B",0.0560111249262281,0,FALSE +"H1299","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.32269,-1.01,0.389,7998,0.57,"HMBS, FTH1, UROS, CP",0.410050398674292,0.244125144327509,FALSE +"H1299","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.50039,-1.56,0.0699,7013,0.205,"SLC27A1, RXRB, ACOX2, APOA1, EHHADH, PDPK1, PCK2, SCP2, CPT2, SORBS1, OLR1, HMGCS2, CYP27A1, FABP7, ACOX1, ACAA1, ACSL1, FABP3, ME1, RXRG, APOA2, LPL, RXRA, ACSL5, FABP1, FADS2",1.15552282425432,0.688246138944246,FALSE +"H1299","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.72431,-2.25,0.00345,7780,0.0431,"SCP2, HSD17B4, AMACR, CYP27A1, CYP7B1, HSD3B7",2.46218090492673,1.36552272983927,TRUE +"H1299","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.37526,-1.17,0.261,8065,0.4,"ADA, LCK, BTK",0.583359492661719,0.397940008672038,FALSE +"H1299","Input","KEGG_PRION_DISEASES",-0.39415,-1.26,0.165,5965,0.361,"NOTCH1, SOD1, MAPK3, BAX, HSPA5, C9, NCAM1, LAMC1, PRKACB, C5, IL6",0.782516055786094,0.442492798094342,FALSE +"H1299","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.23397,0.746,0.776,2064,1,"HSP90AA1, CDK1, BUB1, CCNB1, ANAPC4, ANAPC5, AKT1, HSP90AB1, CDC16, CCNB2, CDC27, ANAPC1, PLK1, AKT2, AKT3, ANAPC7, CDC23, MAD2L2",0.110138278741812,0,FALSE +"H1299","Input","KEGG_PROPANOATE_METABOLISM",-0.61286,-1.94,0.0177,7127,0.105,"ACSS2, ALDH9A1, SUCLA2, EHHADH, SUCLG2, SUCLG1, HIBCH, ALDH3A2, LDHA, PCCA, ACSS3, ALDH6A1, ACSS1, PCCB, ALDH2, ABAT, ALDH1B1, MCEE",1.75202673363819,0.978810700930062,TRUE +"H1299","Input","KEGG_PROSTATE_CANCER",-0.30791,-0.982,0.45,6891,0.592,"HSP90B1, SOS1, CREB5, HRAS, CREB1, PDPK1, IGF1R, TCF7L2, GSK3B, FOXO1, CREBBP, TCF7L1, EP300, PIK3CD, CCND1, LEF1, ERBB2, AR, CREB3L2, CTNNB1, NFKBIA, GSTP1, TP53",0.346787486224656,0.22767829327708,FALSE +"H1299","Input","KEGG_PROTEASOME",0.21338,0.689,0.872,4175,1,"SEM1, PSMC1, POMP, PSMB5, PSMC2, PSMD4, PSMD6, PSME4, PSMB4, PSMB7, PSMD1, PSMB6, PSMB2, PSMD13, PSMD8, PSMD11, PSMC5, PSMA8, PSMF1, PSMD12, PSMD3, PSMD14, PSMA4, PSMB1, PSMD7, PSMD2, PSMC6, PSMC4, PSMA1, PSMA2, PSMA3",0.0594835150674328,0,FALSE +"H1299","Input","KEGG_PROTEIN_EXPORT",0.22507,0.717,0.822,2880,1,"SEC63, SRPRA, OXA1L, SRPRB, SRP14, IMMP2L",0.0851281824599496,0,FALSE +"H1299","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.65934,-2.05,0.00543,7168,0.109,"ATP1A3, ATP1A1, SLC25A10, PCK2, ATP1B3, CA2, MDH1, ATP1A4, AQP1, ATP1B1, GLUD2",2.26520017041115,0.962573502059376,TRUE +"H1299","Input","KEGG_PURINE_METABOLISM",0.15772,0.498,0.996,2599,0.995,"NT5E, PRIM1, NME6, POLR1E, PRIM2, POLA1, POLE, ADCY10, POLA2, POLE2, PDE1C, POLR2B, NME1, HPRT1, POLE3, POLR2K, RRM2B, POLR2A, PDE6D, RRM2, NT5C3A, GART, POLR2G, NUDT2, PFAS, PNPT1, DGUOK, NME2, GMPS, NT5C2, PDE6C, GMPR2",0.00174066157630127,0.00217691925427455,FALSE +"H1299","Input","KEGG_PYRIMIDINE_METABOLISM",0.27474,0.869,0.622,1879,1,"NT5E, PRIM1, NME6, POLR1E, DHODH, PRIM2, POLA1, POLE, POLA2, POLE2, POLR2B, NME1, UMPS, UCKL1, TXNRD2, POLE3, DUT, POLR2K, RRM2B, POLR2A, TYMS, RRM2, NT5C3A",0.206209615309181,0,FALSE +"H1299","Input","KEGG_PYRUVATE_METABOLISM",-0.39668,-1.25,0.183,7127,0.356,"ACSS2, DLAT, ALDH9A1, PCK2, MDH1, AKR1B1, ALDH3A2, PC, LDHA, HAGH, ACSS1, ME1, ALDH2, ALDH1B1",0.737548910269571,0.448550002027125,FALSE +"H1299","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.18943,-0.585,0.949,7119,0.997,"PIP4K2B, ITGB3, PIP4K2A, HRAS, WASL, RAC1, ITGA2B, CFL1, VAV2, ITGA1, CYFIP2, ITGB8, FGFR4, GNA13, BRK1, WASF2, ARHGAP35, IQGAP2, ARHGEF6, APC, FGD1, GIT1, PIK3CD, ITGAV, MYL9, ITGB2, ACTG1, BAIAP2, MYLK, ITGA7, MYH14, ITGB4, SCIN, ENAH, FN1, DIAPH2, ITGB6, RAC2",0.0227337875727074,0.00130484168834428,FALSE +"H1299","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.54176,1.72,0.0351,2579,0.702,"GABARAPL2, ULK1, ATG7, GABARAPL1, ATG5, PIK3R4, ULK3, ATG12, PRKAA1, ATG4B, PIK3C3, ATG3",1.45469288353418,0.153662887870195,FALSE +"H1299","Input","KEGG_RENAL_CELL_CARCINOMA",0.25385,0.827,0.666,1929,1,"TGFB1, PAK4, JUN, RAP1B, ETS1, AKT1, FH, AKT2, FLCN, CRK, AKT3",0.176525770829699,0,FALSE +"H1299","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.41002,1.33,0.142,3212,0.861,"ANPEP, MME, MAS1, THOP1, CTSA, ACE, LNPEP",0.847711655616944,0.0649968485463452,FALSE +"H1299","Input","KEGG_RETINOL_METABOLISM",-0.47988,-1.5,0.083,8546,0.233,"CYP3A5, PNPLA4, DHRS4, ALDH1A1, ALDH1A2",1.08092190762393,0.632644078973981,FALSE +"H1299","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.45108,-1.41,0.114,7317,0.288,"ACP5, FLAD1, ENPP1, ACP6",0.943095148663527,0.540607512240769,FALSE +"H1299","Input","KEGG_RIBOSOME",0.5487,1.75,0.0306,3176,0.938,"RPL22, RPL26L1, RPL7, RPL8, RPL6, RPS23, RPL14, RPL28, RPL29, RPL19, RPL7A, RPS8, RPL36, RPS11, RPL37A, FAU, RPL26, RPL17, RPL23A, RPL34, RPL15, RPL36A, RPL36AL, RPL35A, RPS3A, RPL18, RPL21, RPL10A, RPL32, RPL13A, RPL4, RPL38, RPS6, RPS18, RPL27A, RPS13, RPL31, RPL23, RPS9, RPS29, RPS5, UBA52, RPS24, RPL30, RPL9, RPL37, RPS4X, RPS12, RPS15, RPS19, RPS25, RPL24, RSL24D1, MRPL13, RPL13, RPS17, RPL18A, RPL5, RPL3, RPL27, RPL35, RPL10, RPS2, RPS15A",1.51427857351842,0.0277971616209356,FALSE +"H1299","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.25725,-0.8,0.693,7646,0.857,"ISG15, MAP3K1, SIKE1, MAVS, CYLD, NFKBIA, DDX3Y, MAPK13, CASP10",0.159266765388193,0.0670191780768018,FALSE +"H1299","Input","KEGG_RNA_DEGRADATION",0.22372,0.721,0.832,3281,1,"MTREX, EXOSC10, EXOSC5, EXOSC7, EXOSC9, EXOSC3, XRN1, EXOSC8, EXOSC1, PNPT1, EXOSC6, LSM1, CNOT4, CNOT6L, EXOSC2, LSM2, HSPD1, HSPA9, PAPOLA, PATL1, CNOT2",0.0798766737092761,0,FALSE +"H1299","Input","KEGG_RNA_POLYMERASE",0.19896,0.617,0.924,3472,1,"POLR1E, POLR2B, POLR2K, POLR2A, POLR2G, POLR2E, POLR2I, POLR2J, POLR3G, POLR2C",0.0343280287798933,0,FALSE +"H1299","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.31116,-0.978,0.416,6936,0.592,"PAPSS1, GGT7, SEPHS1, AHCYL1, SCLY, MAT1A, GGT1, CTH",0.380906669373257,0.22767829327708,FALSE +"H1299","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.39391,-1.23,0.198,8251,0.374,"PIK3CD, SKP2, ITGAV, CCND1, LAMA3, LAMA4, LAMA1, PTGS2, NFKBIA, LAMA5, FHIT, LAMB1, COL4A1, RXRG, TRAF4, FN1, RXRA, TP53, COL4A2",0.703334809738469,0.42712839779952,FALSE +"H1299","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.1493,-0.467,0.996,9227,0.997,"VAMP8",0.00174066157630127,0.00130484168834428,FALSE +"H1299","Input","KEGG_SPHINGOLIPID_METABOLISM",0.33909,1.1,0.31,970,0.885,"UGCG, UGT8, SMPD2, SGPP1, GALC, KDSR, PLPP2",0.508638306165727,0.0530567293021746,FALSE +"H1299","Input","KEGG_SPLICEOSOME",0.53244,1.7,0.0507,3386,0.561,"DHX16, ALYREF, DHX38, BUD31, PRPF8, HNRNPA1, SNRPA, CDC5L, DDX23, PRPF6, RBM25, EFTUD2, SNRNP200, PRPF3, SNRPD3, CDC40, USP39, CTNNBL1, HNRNPU, SRSF9, PRPF31, PLRG1, AQR, SNRPE, MAGOHB, WBP11, SF3B4, BCAS2, NCBP1, SNRNP40, TXNL4A, U2AF2, SART1, RBM22, SF3B1, PPIL1, DDX39B, PUF60, HSPA1A, SNW1, DDX5, SNRPB, PRPF38A, RBMX, SYF2, XAB2, PQBP1, EIF4A3, CHERP, U2AF1, SLU7, HSPA8, SRSF6, TCERG1, NCBP2, TRA2B, TRA2A, SNRPB2, PRPF19, SNRPD1, SNRPD2, PRPF40A, SRSF5, HNRNPC, SNRPC, SNU13, SF3A3, SNRPG, SNRPA1, LSM2, SF3B6, HSPA6, SNRPF, SF3A1, PHF5A, SRSF1, PRPF4, CWC15, HNRNPM, SRSF4, U2SURP, DDX46, SF3A2, SMNDC1, CRNKL1",1.29499204066666,0.251037138743839,FALSE +"H1299","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.55258,-1.77,0.0251,5917,0.138,"SI, GBE1, UGP2, AGL, GUSB, HK2, HK3, PYGB, PGM2L1, GANC, PYGL, UGDH, ENPP1, HK1, PGM1, UXS1, GYS1, GAA",1.60032627851896,0.860120913598763,TRUE +"H1299","Input","KEGG_STEROID_BIOSYNTHESIS",-0.62292,-1.95,0.013,6846,0.107,"LSS, CEL, LIPA, FDFT1, EBP, HSD17B7, DHCR7, SC5D, DHCR24, SQLE, MSMO1",1.88605664769316,0.97061622231479,TRUE +"H1299","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.7242,-2.26,0,7022,0.0458,"HSD17B8, AKR1C3, HSD17B12, AKR1C1, AKR1C2, HSD17B7, CYP1B1, CYP7B1, CYP3A5, HSD17B2, HSD3B1, STS, HSD11B2, CYP21A2",Inf,1.33913452199613,TRUE +"H1299","Input","KEGG_SULFUR_METABOLISM",-0.57833,-1.82,0.0302,6936,0.122,"PAPSS1, CHST11, BPNT1, CHST13, CHST12, SULT1A1, SULT1A3",1.51999305704285,0.913640169325252,TRUE +"H1299","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.22562,0.733,0.812,2791,1,"ELANE, CD40, SNRPD3, SNRPB, ACTN4, ACTN1, SNRPD1, C2",0.0904439707588247,0,FALSE +"H1299","Input","KEGG_TASTE_TRANSDUCTION",-0.58189,-1.82,0.0267,6807,0.122,"GNAS, GNB1, PRKACB, GNB3, CACNA1A",1.57348873863542,0.913640169325252,TRUE +"H1299","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.47691,-1.49,0.0897,7560,0.236,"MVK, HMGCR, HMGCS2, GGPS1, HMGCS1",1.04720755695591,0.627087997029893,FALSE +"H1299","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.23701,0.76,0.774,1541,1,"TGFB1, SMURF1, SMURF2, THBS3, ZFYVE9, PPP2R1B, ACVR1, MYC",0.111259039317107,0,FALSE +"H1299","Input","KEGG_THYROID_CANCER",-0.59161,-1.85,0.0299,7024,0.122,"RXRB, PAX8, HRAS, CCDC6, TCF7L2, TCF7L1, CCND1, NCOA4, LEF1, CTNNB1, RXRG, RXRA, TP53, CDH1",1.52432881167557,0.913640169325252,TRUE +"H1299","Input","KEGG_TIGHT_JUNCTION",-0.47267,-1.48,0.0781,7888,0.234,"SRC, CDK4, TJP3, AMOTL1, MAP3K20, EXOC4, PPP2R2A, PATJ, MYL9, PRKCH, PARD6G, F11R, ACTG1, PPP2R2B, PARD6B, TJP2, MYH14, MYH7B, PRKCD, CTNNB1, SPTAN1, EPB41, LLGL2, EPB41L3, CLDN3, CTNNA1, CLDN4, CTNNA2, CLDN6, PRKCQ, EPB41L1, CLDN7, CRB3",1.1073489661227,0.630784142589857,FALSE +"H1299","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.24179,-0.757,0.774,8511,0.887,"TOLLIP, NFKBIA, IL6, MAPK13, MAP2K6, MYD88",0.111259039317107,0.0520763801682736,FALSE +"H1299","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.528,-1.65,0.0429,7164,0.17,"ALDH9A1, KYNU, EHHADH, MAOA, ALDH3A2, GCDH, CYP1B1, DDC, ALDH2, MAOB, ALDH1B1",1.36754270781528,0.769551078621726,TRUE +"H1299","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.43264,-1.36,0.134,5981,0.304,"IKBKB, PIK3R2, HK2, PIK3R3, HK3, MAPK3, PDX1, MAPK8, ABCC8, HK1, PIK3CD, INSR, IRS2, PRKCD, CACNA1A",0.872895201635192,0.517126416391246,FALSE +"H1299","Input","KEGG_TYROSINE_METABOLISM",-0.46463,-1.48,0.0829,8463,0.234,"DDC, DCT, HGD, ALDH3A1, TYRP1, MAOB, ALDH1A3, GSTZ1",1.08144546944973,0.630784142589857,FALSE +"H1299","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.1836,-0.567,0.966,7371,0.983,"NCK2, PDPK1, VAV2, CBLB, GSK3B, CDK4, DLG1, PIK3CD, LCK, PTPN6, NFKBIA, MAPK13, PRKCQ",0.0150228735845067,0.00744648216786438,FALSE +"H1299","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29335,0.921,0.482,1847,1,"FBXO2, UBE2W, SMURF1, FBXW7, TRIP12, UBE4B, CDC34, NEDD4, CUL7, ANAPC4, BIRC2, SMURF2, CBL, HERC4, ANAPC5, UBE2B, BIRC6, UBE2K, CDC20, FANCL, CDC16, UBE2G1, CDC27, TRAF6, FBXO4, ANAPC1, CUL3, HERC2",0.31695296176115,0,FALSE +"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.3668,1.19,0.215,3335,0.926,"BCAT1, VARS2, PDHA1",0.667561540084395,0.0333890133180656,FALSE +"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.54959,-1.74,0.0387,7850,0.14,"DBT, HIBCH, ALDH3A2, AUH, PCCA, HMGCS2, ALDH6A1, ACAA1, HMGCS1, ACADS, PCCB, ALDH2, ABAT, ALDH1B1, HIBADH, MCEE",1.41228903498109,0.853871964321762,TRUE +"H1299","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.3999,-1.25,0.193,7247,0.356,"ADCY9, GUCY1A1, MYH11, GNA11, MYL6B, GNAQ, GNA13, MYL6, ARHGEF11, PRKACB, MYL9, PLA2G12A, PRKCH, MYLK, PRKCD, ADCY5, PLCB1, PLA2G4A, PRKCQ",0.714442690992226,0.448550002027125,FALSE +"H1299","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.23715,-0.746,0.761,6807,0.898,"GNAS, AVP, DCTN6, CREB5, ADCY9, CREB1, RAB5C, PRKACB, DYNLL2, ARHGDIB, CREB3L2",0.118615343229427,0.0467236633326956,FALSE +"H1299","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.247,-0.786,0.726,8251,0.875,"PIK3CD, PLA2G12A, PTGS2, PLA2G4A, MAPK13, RAC2",0.139063379299906,0.0579919469776868,FALSE +"H1299","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.44029,-1.36,0.135,6334,0.304,"ATP6V0A1, ATP6V1G1, ATP6V0C, ATP6AP1, PLCG2, ATP6V1E1, GNAS, TJP1, ATP6V1F, ADCY9, ATP6V1C2, KDELR3, SLC12A2, PRKACB, ATP6V0D1, ATP6V0D2, PDIA4, ACTG1, TJP2, KDELR1",0.869666231504994,0.517126416391246,FALSE +"H1299","Input","KEGG_VIRAL_MYOCARDITIS",-0.37315,-1.17,0.244,8387,0.4,"ITGB2, CCND1, ACTG1, CD55, MYH14, MYH7B, SGCD, RAC2",0.612610173661271,0.397940008672038,FALSE +"H1299","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.29815,-0.942,0.484,7299,0.638,"RAC1, CTBP2, CSNK1E, TBL1XR1, TCF7L2, SFRP1, FZD7, PRKACB, DKK1, GSK3B, CREBBP, APC, TCF7L1, TBL1X, EP300, PPP2R5A, CCND1, LEF1, DAAM2, NKD2, WNT16, CTNNB1, PLCB1, DAAM1, TP53, RAC2, WNT11",0.315154638355588,0.195179321278838,FALSE +"H1703","Input","KEGG_ABC_TRANSPORTERS",-0.4043,-1.2,0.221,7682,0.586,"ABCD4, ABCD3, ABCC3, ABCG2, ABCA2, ABCB6, ABCA1",0.655607726314889,0.232102383981909,FALSE +"H1703","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.27251,-0.801,0.733,6970,0.933,"PML, MYC, PIK3CA, TCF7L2, PIM1, PIK3CB, HRAS, PIK3R1, PIK3R2, PIK3CD, CCND1, RUNX1",0.134896025358872,0.0301183562535,FALSE +"H1703","Input","KEGG_ADHERENS_JUNCTION",-0.28153,-0.826,0.677,7033,0.926,"PTPN6, RAC3, MET, TCF7L2, BAIAP2, CTNNA2, TGFBR1, CTNNA1, PTPRF, PTPN1, SNAI2, CTNNB1, ACTN4, CTNND1, IGF1R, RAC2, WAS",0.169411331314856,0.0333890133180656,FALSE +"H1703","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.23757,0.749,0.782,2487,0.957,"STAT3, ACACB, NFKBIE, MAPK9, TNFRSF1A, MAPK10, IKBKG, CPT1A, NFKBIB, CPT1C, RELA, PRKAB2, MAPK8, CAMKK2, TRAF2, AKT1, TRADD, STK11, PRKAB1, NFKB1, PRKAG2",0.106793246940152,0.0190880622231565,FALSE +"H1703","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.36686,1.1,0.307,1463,0.894,"GLUL, ASNS, GLUD2, NIT2, ADSL, ASL, CAD, GOT1",0.512861624522813,0.0486624812040823,FALSE +"H1703","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.50319,-1.47,0.0954,6972,0.418,"HSD11B2, PIK3CA, IRS2, PIK3CB, PDPK1, SFN, ATP1A2, PIK3R1, IRS1, PIK3R2, SLC9A3R2, PIK3CD",1.0204516252959,0.378823718224965,FALSE +"H1703","Input","KEGG_ALZHEIMERS_DISEASE",0.28813,0.892,0.542,3141,0.994,"GRIN1, ATP2A3, GAPDH, COX6A1, PSEN2, COX6C, TNFRSF1A, PLCB2, NDUFA4, CASP7, CAPN1, COX7C, ITPR2, PLCB3, NDUFA8, COX7A2, CASP9, SDHA, MAPT, SDHB, BID, ATP5F1B, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, IDE, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, ATP5PD, UQCRQ, UQCRC1, CASP3, NDUFA7, CDK5, UQCRH, CALML3, NDUFC1, BAD, NDUFB5, NDUFS5, CYCS, NDUFA2, SDHD, CALM2, BACE2, NDUFB1, GNAQ, NDUFC2, CASP8, COX5A, NDUFB10, NDUFS7, PSEN1, UQCRC2, ATP5PB, NDUFS8, NDUFV3",0.266000713461613,0.00261361560268669,FALSE +"H1703","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.22961,-0.671,0.894,7187,0.99,"NARS2, EARS2, PARS2, CARS2, MARS2",0.0486624812040823,0.00436480540245009,FALSE +"H1703","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.23201,0.724,0.849,2568,0.971,"AMDHD2, UAP1, NANS, PGM1, FPGT, PMM1, GALK1, GNPDA2, HEXB, GNPDA1, GPI, CMAS, GNE, PGM3",0.0710923097560473,0.0127807700919951,FALSE +"H1703","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.24648,-0.729,0.797,9109,0.941,"GPX1, CASP1, TOMM40L",0.0985416786038876,0.0264103765727431,FALSE +"H1703","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.4093,1.24,0.201,1493,0.787,"TAPBP, TAP1, CTSL, HSPA4, RFXAP, B2M, TAP2, RFXANK, IFI30, RFX5, HSP90AB1",0.696803942579511,0.104025267640935,FALSE +"H1703","Input","KEGG_APOPTOSIS",0.23804,0.748,0.788,1398,0.942,"DFFA, RIPK1, PRKAR2B, TNFRSF1A, IL1A, ATM, XIAP, AIFM1, CASP7, IKBKG, CAPN1, MYD88, DFFB, CASP9, RELA, BID",0.103473782510445,0.0259490972071227,FALSE +"H1703","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.68528,-2.03,0.00503,8675,0.123,"GGT5, PTGES, EPHX2, GPX6, GPX7, GPX1, PTGS2",2.29843201494407,0.910094888560602,TRUE +"H1703","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.40013,-1.18,0.24,7871,0.57,"ALDH18A1, CKMT1A, SAT1, P4HA1, CKMT2, GLS, GLS2, P4HA2, ASS1, PRODH, PRODH2, CPS1, MAOA, AGMAT, ARG2, ARG1, LAP3",0.619788758288394,0.244125144327509,FALSE +"H1703","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.61267,-1.85,0.0235,7584,0.211,"CTNNA2, ITGA11, DSG2, ITGA6, CTNNA1, ATP2A2, ITGA1, ITGA4, DSC2, ITGB6, ITGB4, ITGA7, CTNNB1, ACTN4, ITGB3, SLC8A1, GJA1, ITGA2, ITGB8",1.62893213772826,0.675717544702307,TRUE +"H1703","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.52978,1.68,0.0366,110,0.526,"ALDH3A2",1.43651891460559,0.279014255846261,FALSE +"H1703","Input","KEGG_AXON_GUIDANCE",-0.3431,-1.04,0.369,6981,0.645,"RGS3, PTK2, RAC3, GNAI3, PPP3R1, EPHA6, MET, PAK4, ARHGEF12, PPP3CA, EFNA1, PPP3CC, DPYSL5, GNAI1, HRAS, EPHA1, NRP1, EPHA4, SEMA4G, NTN4, PLXNA2, EPHA7, EFNB2, ABLIM1, ABLIM3, EPHB2, SEMA7A, RAC2, NFATC4, CXCR4",0.43297363384094,0.190440285364732,FALSE +"H1703","Input","KEGG_BASAL_CELL_CARCINOMA",0.32135,0.988,0.404,870,0.93,"GLI3, DVL2, FZD2",0.393618634889395,0.0315170514460649,FALSE +"H1703","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.19091,-0.566,0.972,6148,1,"TAF4, TAF5L, GTF2E1, TAF5, GTF2A1, TAF1, GTF2H4, GTF2I, GTF2H2, GTF2H3, GTF2H1",0.0123337350737254,0,FALSE +"H1703","Input","KEGG_BASE_EXCISION_REPAIR",0.26895,0.809,0.711,2966,0.937,"MUTYH, PARP4, POLD4, HMGB1, NEIL2, PCNA, APEX1, POLL, POLE, POLD2, NTHL1",0.148130399270234,0.0282604091122217,FALSE +"H1703","Input","KEGG_BETA_ALANINE_METABOLISM",0.33325,1.02,0.387,993,0.937,"ALDH3A2, SMS",0.412289034981089,0.0282604091122217,FALSE +"H1703","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.30453,-0.909,0.533,7063,0.811,"ACOT2, ACOX3, ACOX1, TECR, HSD17B12, FADS2, ELOVL6",0.273272790973428,0.090979145788844,FALSE +"H1703","Input","KEGG_BLADDER_CANCER",-0.47013,-1.41,0.0987,7425,0.475,"DAPK1, CDK4, VEGFC, HRAS, TYMP, THBS1, VEGFA, MMP2, CCND1, CDKN1A",1.00568284733036,0.323306390375133,FALSE +"H1703","Input","KEGG_BUTANOATE_METABOLISM",-0.43968,-1.31,0.151,7866,0.558,"HMGCS1, BDH2, ABAT, ACSM3, BDH1, HMGCS2, ACADS",0.821023052706831,0.253365801062421,FALSE +"H1703","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.35552,-1.07,0.333,7033,0.664,"PTPN6, RAC3, PPP3R1, PIK3CA, LYN, PPP3CA, PPP3CC, PIK3CB, VAV3, HRAS, PIK3R1, SYK, PIK3R2, PIK3AP1, CD81, PIK3CD, INPP5D, RAC2, NFATC4",0.47755576649368,0.177831920631982,FALSE +"H1703","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2345,0.709,0.837,1722,0.98,"PDGFRA, GRIN1, ATP2A3, RYR1, PLCB2, ITPR2, PLCB3, PLCG2, PLCD1, TACR1, NOS3, PHKA1, PHKB, PRKACA, PRKCA, PPID",0.07727454200674,0.00877392430750515,FALSE +"H1703","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.3647,1.09,0.303,2335,0.848,"CACNA2D1, TPM2, COX6A1, COX6C, COX7C, TPM3, COX7A2, TPM1, UQCRB, COX5B, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, UQCRQ, UQCRC1, UQCRH",0.518557371497695,0.0716041477432862,FALSE +"H1703","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.4641,-1.37,0.135,7987,0.526,"PTPRC, PTPRF, CNTN1, ITGA4, NRCAM, ICAM1, CLDN7, ICAM2, SDC1, PDCD1LG2, CLDN3, SDC2, CADM1, SDC4, NCAM1, VCAN, CD274, PECAM1, F11R, ITGB8",0.869666231504994,0.279014255846261,FALSE +"H1703","Input","KEGG_CELL_CYCLE",-0.14348,-0.419,1,7005,1,"TP53, BUB1B, ORC6, MYC, CCND3, CDK7, CCNB2, SKP2, CDK4, TGFB3, CDC7, SFN, BUB1, RBL1, WEE1, CDC6, TGFB2, CCND1, CDKN1A",0,0,FALSE +"H1703","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.3855,-1.15,0.236,7014,0.589,"CCL13, RAP1B, PTK2, GNAI3, CCL20, PLCB4, PIK3CA, GNG5, CXCL6, JAK3, ARRB1, GNB1, LYN, PRKCD, RAP1A, GNB3, PIK3CB, GNAI1, STAT2, VAV3, HRAS, ADCY9, PIK3R1, GNG2, PIK3R2, PTK2B, PIK3CD, RAC2, CXCR4, WAS, CXCL1",0.627087997029893,0.229884705212898,FALSE +"H1703","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.35831,-1.06,0.372,7539,0.638,"CDK4, PIK3CB, TGFB3, TGFBR1, BCL2L1, HRAS, PIK3R1, CBLB, PIK3R2, PIK3CD, MECOM, TGFB2, GAB2, CCND1, RUNX1, CDKN1A",0.429457060118102,0.195179321278838,FALSE +"H1703","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.35652,-1.04,0.364,6420,0.645,"CSNK1D, CLOCK, BHLHE41, BHLHE40, CSNK1E",0.438898616350944,0.190440285364732,FALSE +"H1703","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.13956,-0.404,1,1286,1,"ACO2, SDHA, SDHB, MDH1, ACLY, DLD, SDHD, FH, PCK2, PDHB, IDH3A, PDHA1, ACO1, SDHC, IDH3G, SUCLG2, SUCLG1, OGDH, OGDHL, MDH2, IDH1, DLAT, SUCLA2, IDH3B, IDH2, DLST, CS, PC, PCK1",0,0,FALSE +"H1703","Input","KEGG_COLORECTAL_CANCER",-0.25572,-0.766,0.772,7005,0.916,"TP53, RAC3, MYC, PIK3CA, TCF7L2, PIK3CB, TGFB3, TGFBR1, APC, PIK3R1, CTNNB1, PIK3R2, PIK3CD, TGFB2, RAC2, CCND1",0.112382699664264,0.0381045263321496,FALSE +"H1703","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.37835,-1.11,0.304,7762,0.607,"PROC, PLAT, C9, F5, PLAUR, C3, THBD, PLAU, SERPINA1, CD59, SERPINC1, CD55, MBL2",0.517126416391246,0.216811308924742,FALSE +"H1703","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.27725,0.864,0.588,1617,0.994,"LDHB, MTAP, CDO1, SMS, MPST, GOT1, MAT2B, AHCY",0.230622673923862,0.00261361560268669,FALSE +"H1703","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.32933,-0.971,0.445,8580,0.722,"EPO, IL6, VEGFA, IL1RAP, ACVR1B, TGFB2, TNFRSF12A, IL1R1, CXCR4, CXCL1, LTBR",0.351639989019068,0.141462802430361,FALSE +"H1703","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.33329,-0.974,0.467,7330,0.726,"ADAR, POLR3D, POLR3H, POLR3A, POLR3K, POLR3B, IL6, PYCARD, TREX1, CASP1",0.330683119433888,0.139063379299906,FALSE +"H1703","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.53769,-1.59,0.0519,7673,0.325,"TGFB3, ITGA11, TTN, GNAS, ITGA6, ATP2A2, ITGA1, ITGA4, ADCY9, ITGB6, ITGB4, ITGA7, TNNC1, ITGB3, SLC8A1, TGFB2, ITGA2, ITGB8",1.28483264215154,0.488116639021126,FALSE +"H1703","Input","KEGG_DNA_REPLICATION",0.36361,1.12,0.281,4066,0.923,"RNASEH2C, RPA3, POLD4, MCM5, RFC4, POLA2, POLA1, MCM3, PCNA, POLE, POLD2, PRIM2, MCM7, MCM4, RFC2, MCM6, RFC5, RNASEH2B, RNASEH2A, PRIM1, LIG1, POLD3, MCM2, RPA2",0.55129368009492,0.0347982989740879,FALSE +"H1703","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.55424,1.69,0.0312,2068,0.606,"ETS1, NOTCH3, SPIRE1, SPIRE2, EGFR, NOTCH2",1.50584540598156,0.217527375833714,FALSE +"H1703","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.50548,-1.49,0.0941,8388,0.407,"ALDH3A1, GSTM4, GSTM1, MAOA, GSTT2, GSTM2, MGST1",1.02641037657274,0.39040559077478,FALSE +"H1703","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.2743,-0.815,0.673,8059,0.927,"NAT2, TYMP, CES1, CES2, CDA",0.171984935776023,0.0329202658555029,FALSE +"H1703","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.7124,-2.09,0.00166,8151,0.123,"HSPG2, ITGA1, ITGA4, COL6A3, COL1A2, ITGB6, ITGB4, VTN, COL11A1, LAMB3, ITGA7, LAMC2, LAMA3, LAMA4, SDC1, FN1, THBS1, COL5A1, CD36, TNC, SDC2, COL6A1, LAMB1, ITGB3, COL3A1, SDC4, AGRN, ITGA2, CD44, ITGB8",2.77989191195995,0.910094888560602,TRUE +"H1703","Input","KEGG_ENDOCYTOSIS",0.16136,0.489,0.998,676,1,"PDGFRA, PLD2, DNM1L, IQSEC1, EPN2, RAB11FIP3, VPS4B, RUFY1, RABEP1, STAM2",0.000869458712628891,0,FALSE +"H1703","Input","KEGG_ENDOMETRIAL_CANCER",-0.40798,-1.21,0.21,7005,0.581,"TP53, MYC, PIK3CA, TCF7L2, CTNNA2, PIK3CB, PDPK1, ILK, APC, CTNNA1, HRAS, PIK3R1, CTNNB1, PIK3R2, PIK3CD, CCND1",0.677780705266081,0.235823867609669,FALSE +"H1703","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.26972,-0.795,0.709,6469,0.923,"TJP1, JUN, ATP6V1A, ATP6V1C2, ATP6V0A2, ATP6V0C, ATP6V1B2, ATP6V0D1, ATP6V1G2, MET, TCIRG1, ATP6V1D, ATP6V1B1, LYN, ATP6V1H, JAM2, ADAM10, MAPK13, F11R, CXCL1",0.149353764816933,0.0347982989740879,FALSE +"H1703","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.18882,-0.547,0.981,7051,1,"PTK2, MYC, PIK3CA, PAK4, TGFA, CAMK2D, PIK3CB, MAP2K7, HRAS, PIK3R1, CBLB, PIK3R2, PIK3CD, ERBB3, CDKN1A",0.0083309926200515,0,FALSE +"H1703","Input","KEGG_ETHER_LIPID_METABOLISM",-0.26861,-0.796,0.689,7594,0.932,"PAFAH2, PLA2G4A, LPCAT2, PLPP3, CHPT1",0.161780778092374,0.0305840876460186,FALSE +"H1703","Input","KEGG_FATTY_ACID_METABOLISM",0.28387,0.88,0.575,1424,0.975,"ALDH3A2, ACAA2, ECI1, ACAT1, CPT1A, ADH5, CPT1C, ECI2",0.24033215531037,0.0109953843014632,FALSE +"H1703","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.44762,-1.3,0.156,7041,0.558,"PLA2G12A, RAC3, PIK3CA, LYN, PRKCD, PIK3CB, MAP2K7, PDPK1, PLA2G4A, VAV3, HRAS, PIK3R1, MAPK13, LCP2, SYK, PIK3R2, PIK3CD, INPP5D, RAC2, GAB2",0.806875401645538,0.253365801062421,FALSE +"H1703","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.39254,-1.16,0.247,7878,0.584,"PLA2G4A, AMPH, VAV3, PTPRC, PIP5K1C, PIK3R1, PLA2G4F, MYO10, ASAP2, SYK, ARPC1A, MARCKS, PLPP3, PIK3R2, SCIN, PIK3CD, INPP5D, RAC2, GAB2, WAS",0.607303046740334,0.233587152887601,FALSE +"H1703","Input","KEGG_FOCAL_ADHESION",-0.39802,-1.17,0.235,8188,0.578,"PIP5K1C, ITGA1, ITGA4, PIK3R1, COL6A3, PDGFRB, COL1A2, ITGB6, ITGB4, VTN, COL11A1, LAMB3, FLNC, ITGA7, LAMC2, CTNNB1, PIK3R2, LAMA3, LAMA4, PARVA, ACTN4, FN1, THBS1, COL5A1, VEGFA, TNC, COL6A1, LAMB1, ITGB3, PIK3CD, COL3A1, IGF1R, RAC2, ITGA2, CCND1, FLNB, ITGB8",0.628932137728264,0.238072161579471,FALSE +"H1703","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.62193,-1.83,0.0281,8632,0.21,"QDPR, PTS",1.55129368009492,0.677780705266081,TRUE +"H1703","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.2272,0.698,0.845,1679,0.966,"TPI1, PHPT1, AKR1B1, FPGT, PMM1, MTMR6, PFKFB3",0.0731432910503077,0.0150228735845067,FALSE +"H1703","Input","KEGG_GALACTOSE_METABOLISM",-0.22831,-0.665,0.888,6436,0.979,"GALE, GAA, PGM2, HK3, PFKM, MGAM, B4GALT1",0.051587034221399,0.00921730819686218,FALSE +"H1703","Input","KEGG_GAP_JUNCTION",0.366,1.13,0.277,1351,0.941,"PDGFRA, MAPK7, TUBB2B, PDGFC, TUBA3C, TUBB6, PLCB2, TUBA1C, TUBB1, TUBB3, ITPR2, PLCB3, TUBB, TUBB2A, RAF1",0.557520230935551,0.0264103765727431,FALSE +"H1703","Input","KEGG_GLIOMA",-0.25689,-0.75,0.796,8076,0.925,"HRAS, PIK3R1, PDGFRB, PIK3R2, PIK3CD, IGF1R, CCND1, CDKN1A",0.0990869322623309,0.0338582672609674,FALSE +"H1703","Input","KEGG_GLUTATHIONE_METABOLISM",-0.54723,-1.62,0.0377,8605,0.323,"GSTM4, GGT5, GSTM1, ANPEP, GPX6, GPX7, GPX1, GSTT2, GSTM2, LAP3, MGST1",1.42365864979421,0.490797477668897,FALSE +"H1703","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.51616,-1.5,0.0829,8591,0.412,"PLPP3, DGAT1, LPL, DGKA, DGKB, LIPG, MGLL",1.08144546944973,0.385102783966865,FALSE +"H1703","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.21067,-0.612,0.957,7873,0.996,"GPD1, PLA2G4A, GPD2, LPCAT2, PLPP3, DGKA, CHPT1, DGKB",0.0190880622231565,0.00174066157630127,FALSE +"H1703","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.3134,0.93,0.514,1040,0.919,"SRR, PSAT1, GAMT, MAOB, PIPOX, PHGDH",0.289036881004724,0.0366844886138887,FALSE +"H1703","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.26521,0.81,0.684,1399,0.954,"ALDH3A2, LDHB, TPI1, GAPDH, ENO1, ENO3, PGAM1, PGAM4, ADH5, PGK1, PGM1",0.164943898279884,0.0204516252959049,FALSE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.39567,-1.18,0.234,6744,0.57,"XYLT2, CHST12, B4GALT7, CHPF2, B3GAT3, CHSY1, CHST11, CHPF, CHST14",0.630784142589857,0.244125144327509,FALSE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.70026,-2.02,0.0122,6744,0.111,"XYLT2, B4GALT7, HS2ST1, B3GAT3, GLCE, EXT1, EXTL2, EXTL3, EXT2",1.91364016932525,0.954677021213343,TRUE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.73339,-2.17,0.00505,7501,0.184,"B3GNT2, B4GAT1, B4GALT3, B4GALT4, ST3GAL2, FUT8, B4GALT1",2.29670862188134,0.735182176990464,TRUE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.26112,0.795,0.705,3244,0.932,"HYAL2, HEXB, IDUA, GNS, ARSB, HEXA, HYAL1, GALNS",0.151810883008601,0.0305840876460186,FALSE +"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.47906,1.48,0.0816,124,0.684,"B4GALNT1",1.08830984124614,0.164943898279884,FALSE +"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.4598,-1.35,0.129,8348,0.523,"ST3GAL2, B3GALNT1",0.889410289700751,0.281498311132726,FALSE +"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.78145,-2.32,0,7501,0.137,"B3GNT2, B4GAT1, B3GNT3, ST3GAL4, B4GALT3, B4GALT4, B4GALT1",Inf,0.863279432843593,TRUE +"H1703","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.22373,-0.669,0.906,5264,0.983,"PIGS, PIGM, GPAA1, PIGT, PIGK, PIGO, PGAP1",0.0428718023231869,0.00744648216786438,FALSE +"H1703","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.25732,0.795,0.719,1897,0.932,"PGP, MTHFD1L, ACO2, MDH1",0.143271109617117,0.0305840876460186,FALSE +"H1703","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.21049,0.654,0.92,1668,0.982,"MAPK7, PLD2, ATF4, MAPK9, MAP2K4, PLCB2, MAPK10, ITPR2, PLCB3, RAF1, MAPK8, PRKACA, PRKCA",0.0362121726544447,0.00788851221305034,FALSE +"H1703","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.30363,0.932,0.507,1869,0.938,"GLI3, BTRC, PRKACA, FBXW11",0.294992040666664,0.0277971616209356,FALSE +"H1703","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.72282,-2.13,0.00649,7834,0.12,"ITGA6, MME, CD38, ITGA1, ITGA4, EPO, IL6, CD59, CD55, CD36, ITGB3, ANPEP, ITGA2, IL1R1, CD44",2.18775530319963,0.920818753952375,TRUE +"H1703","Input","KEGG_HISTIDINE_METABOLISM",-0.40597,-1.19,0.233,7974,0.591,"ALDH1A3, ALDH3A1, MAOA, HNMT",0.632644078973981,0.228412519118745,FALSE +"H1703","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.42897,1.3,0.164,3182,0.742,"SEM1, BLM, RPA3, POLD4, MRE11, RAD50, EME1, POLD2, NBN, RAD54L, XRCC3",0.785156151952302,0.129596094720973,FALSE +"H1703","Input","KEGG_HUNTINGTONS_DISEASE",0.37406,1.15,0.258,3261,0.934,"GRIN1, COX6A1, DNAH3, SOD1, COX6C, PLCB2, HIP1, NDUFA4, COX7C, PLCB3, TBPL1, DCTN4, NDUFA8, COX7A2, CASP9, SDHA, SDHB, CLTA, ATP5F1B, DCTN2, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, PPID, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, TBP, CLTB, CREB3L1, ATP5PD, IFT57, CLTC, UQCRQ, REST, UQCRC1, DCTN1, CASP3, NDUFA7, TFAM, UQCRH, BAX, NDUFC1, DNAL1, NDUFB5, POLR2H, NDUFS5, HAP1, CYCS, NDUFA2, SDHD, VDAC1, SP1, DNAL4, NDUFB1, GNAQ, NDUFC2, CASP8, COX5A, NDUFB10, NDUFS7, UQCRC2, ATP5PB, NDUFS8, NDUFV3, ATP5F1D, HTT, COX7B",0.58838029403677,0.0296531237699066,FALSE +"H1703","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.5246,-1.55,0.0726,7673,0.36,"TGFB3, ITGA11, TTN, ITGA6, ATP2A2, ITGA1, ITGA4, ITGB6, ITGB4, ACE, ITGA7, IL6, TNNC1, ITGB3, SLC8A1, TGFB2, ITGA2, ITGB8",1.13906337929991,0.443697499232713,FALSE +"H1703","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.28927,0.88,0.56,1591,0.975,"ISYNA1, TPI1, IMPA1, OCRL, INPP4B, PLCB2, PLCB3, PLCG2, PLCD1, INPP5K, PIK3C3, PTEN",0.2518119729938,0.0109953843014632,FALSE +"H1703","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.25191,0.789,0.724,1865,0.91,"EIF4EBP1, CRK, ACACB, SHC1, ACACA, FLOT2, TRIP10, RPS6KB1, FLOT1, PYGL, MKNK1, MAPK9, PRKAR2B, MAPK10, RAF1, PHKA1, INPP5K, CRKL, PHKB, PRKAB2, MAPK8, FOXO1, PRKACA, SREBF1, SORBS1, INSR, RPTOR",0.140261433802853,0.0409586076789064,FALSE +"H1703","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.58073,-1.74,0.0293,8276,0.264,"ITGA4, IL6, CXCR4, LTBR",1.53313237964589,0.578396073130169,FALSE +"H1703","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.42412,-1.24,0.198,7033,0.588,"PTPN6, MYC, PIK3CA, JAK3, CCND3, STAT6, JAK1, PIM1, LEPR, PIK3CB, IL13RA2, STAT2, SPRY1, BCL2L1, PIK3R1, CBLB, EPO, IL6, PIK3R2, PIK3CD, CCND1, SPRY2",0.703334809738469,0.230622673923862,FALSE +"H1703","Input","KEGG_LEISHMANIA_INFECTION",-0.40624,-1.22,0.217,8254,0.592,"C3, ITGA4, TRAF6, MAPK13, CYBA, TGFB2, PTGS2",0.66354026615147,0.22767829327708,FALSE +"H1703","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.43134,-1.28,0.154,7584,0.579,"CTNNA2, PIK3CB, JAM2, GNAI1, VAV3, CTNNA1, ITGA4, PIK3R1, ICAM1, MAPK13, CLDN7, CTNNB1, PIK3R2, ACTN4, CLDN3, PTK2B, CYBA, PIK3CD, CTNND1, RAC2, PECAM1, MMP2, F11R, CXCR4",0.812479279163537,0.237321436272564,FALSE +"H1703","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.56034,1.7,0.0378,110,0.726,"ALDH3A2",1.42250820016277,0.139063379299906,FALSE +"H1703","Input","KEGG_LONG_TERM_DEPRESSION",-0.34395,-1.02,0.406,7041,0.664,"PLA2G12A, GNAI3, PLCB4, PPP2CB, GNA12, GUCY1A1, LYN, GNA11, GNAI1, GNAS, PLA2G4A, ITPR3, HRAS, PRKG1, IGF1R",0.391473966422806,0.177831920631982,FALSE +"H1703","Input","KEGG_LONG_TERM_POTENTIATION",0.27941,0.845,0.609,2911,0.973,"GRIN1, ATF4, RPS6KA1, PLCB2, ITPR2, PLCB3, RAF1, PRKACA, PRKCA, RPS6KA2, CAMK2G, CALML3, MAP2K2, PRKCB, CALM2, RPS6KA3, GNAQ",0.215382707367125,0.0118871597316481,FALSE +"H1703","Input","KEGG_LYSINE_DEGRADATION",-0.27807,-0.83,0.703,7276,0.93,"SUV39H1, DLST, NSD2, SUV39H2, DOT1L, SETD7, PLOD1, PLOD2, AASS",0.153044674980176,0.0315170514460649,FALSE +"H1703","Input","KEGG_LYSOSOME",0.28238,0.854,0.602,1885,0.996,"MCOLN1, NAGA, SUMF1, GGA2, CTSK, CTSO, IGF2R, CTSL, LAMP3, SLC17A5, PSAPL1, CTSG, CLN5, ARSA, GLA, LAMP2, AP1S1, AP1S2, AP3M1, CLTA, AP3S1, AGA, NPC2, PSAP, GGA3, DNASE2, M6PR, AP1M1, AP3B1, AP3D1, HEXB",0.220403508742175,0.00174066157630127,FALSE +"H1703","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.26549,0.817,0.659,2486,0.978,"PDGFRA, MEF2C, TGFBR2, HSPB1, MAPK7, CACNA2D1, MAP3K20, CRK, RELB, NFKB2, ATF4, MKNK1, MAPK9, RPS6KA1, TNFRSF1A, IL1A, MAP2K4, MAPK10, TGFB1, STMN1, IKBKG, NF1, PPM1B, RAF1, RELA, MAPT, MAP3K7, CRKL, MAPK8, ARRB2, TAB2, PRKACA, PRKCA, RPS6KA2, TAB1, EGFR, PAK1, TRAF2, HSPA1A, TAOK1, AKT1, PAK2, MOS, MAPK12, FLNA, HSPA6, CASP3, MAP2K2, HSPA2, RRAS, RASA1, NFKB1, DUSP3",0.18111458540599,0.00966114521239857,FALSE +"H1703","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.47615,-1.41,0.116,7844,0.475,"HNF1B, PDX1, HNF1A, HNF4A",0.935542010773082,0.323306390375133,FALSE +"H1703","Input","KEGG_MELANOGENESIS",-0.21183,-0.626,0.926,6828,0.993,"CREBBP, GNAO1, DVL3, DVL1, GNAI3, PLCB4, WNT5A, TCF7L2, CAMK2D, GNAI1, GNAS, HRAS, MITF, ADCY9, CTNNB1",0.0333890133180656,0.00305075150461883,FALSE +"H1703","Input","KEGG_MELANOMA",-0.30701,-0.899,0.577,8076,0.823,"HRAS, MITF, PIK3R1, PDGFRB, PIK3R2, PIK3CD, IGF1R, CCND1, CDKN1A",0.238824186844269,0.0846001647877302,FALSE +"H1703","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.54709,-1.63,0.0505,7974,0.331,"ALDH1A3, AKR1C1, ALDH3A1, GSTM4, CYP2S1, GSTM1, GSTT2, GSTM2, MGST1",1.29670862188134,0.480172006224281,FALSE +"H1703","Input","KEGG_MISMATCH_REPAIR",0.5492,1.62,0.0618,1950,0.553,"PMS2, MSH6, MLH1, MSH2, MSH3, RPA3, POLD4, RFC4",1.20901152491118,0.257274868695302,FALSE +"H1703","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.23104,-0.698,0.869,7171,0.982,"PIK3CA, CAB39, RPS6, PIK3CB, PDPK1, VEGFC, PIK3R1, PIK3R2, VEGFA, PIK3CD",0.0609802235513335,0.00788851221305034,FALSE +"H1703","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.37381,-1.11,0.304,7033,0.607,"PTPN6, RAC3, PPP3R1, ITGB2, PIK3CA, RAET1L, ULBP2, PPP3CA, PPP3CC, PIK3CB, TNFRSF10B, VAV3, HRAS, PIK3R1, ICAM1, LCP2, ICAM2, SYK, PIK3R2, PTK2B, PIK3CD, RAC2, NFATC4",0.517126416391246,0.216811308924742,FALSE +"H1703","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.50978,1.55,0.0775,1974,0.613,"GRIN1, CTSG, NR3C1, TACR1, PLG, PRSS1, HRH1",1.11069829749369,0.212539525481585,FALSE +"H1703","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.24435,0.774,0.748,2459,0.924,"NGFR, MAPK7, CRK, SHC1, ATF4, NFKBIE, YWHAH, MAPK9, RPS6KA1, MAPK10, FOXO3, YWHAE, NFKBIB, PLCG2, RAF1, RELA, CRKL, MAPK8, RPS6KA2, KIDINS220, YWHAG, AKT1, YWHAQ, CAMK2G, MAPK12, YWHAB, CALML3, BAX, MAP2K2, NFKB1, BAD",0.126098402135539,0.0343280287798933,FALSE +"H1703","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.3463,-1.03,0.39,7317,0.655,"PNP, QPRT, NT5C3A, CD38, NT5E, NNT",0.408935392973501,0.183758700008217,FALSE +"H1703","Input","KEGG_NITROGEN_METABOLISM",0.38064,1.2,0.22,308,0.843,"GLUL, CA13, ASNS, GLUD2",0.657577319177794,0.0741724253752577,FALSE +"H1703","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.41018,-1.21,0.223,8387,0.581,"TRAF6, MAPK13, IL6, PYCARD, CASP1, TRIP6, CXCL1",0.651695136951839,0.235823867609669,FALSE +"H1703","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.45191,1.39,0.117,2726,0.751,"MRE11, XRCC4, LIG4, RAD50, POLL",0.931814138253838,0.124360062995832,FALSE +"H1703","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.27123,-0.815,0.697,7005,0.927,"TP53, PIK3CA, TGFA, CDK4, RXRA, PIK3CB, PDPK1, HRAS, PIK3R1, PIK3R2, PIK3CD, CCND1",0.156767221901991,0.0329202658555029,FALSE +"H1703","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.26355,0.81,0.665,869,0.954,"NOTCH3, DVL2, NUMBL, PSEN2, MAML2",0.177178354696895,0.0204516252959049,FALSE +"H1703","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.19425,-0.578,0.978,6228,1,"CCNH, MNAT1, RFC1, DDB2, XPC, GTF2H5, GTF2H4, CDK7, POLE4, ERCC2, ERCC3, GTF2H2, GTF2H3, ERCC5, GTF2H1",0.00966114521239857,0,FALSE +"H1703","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.45106,-1.33,0.14,5851,0.541,"MGAT1, ALG11, DAD1, DDOST, TUSC3, RPN2, ALG14, DPM3, ALG1, MGAT3, MGAT2, ALG9, MOGS, MAN2A1, MAN2A2, MAN1A1, MAN1A2, MAN1B1, B4GALT3, DOLPP1, FUT8, MGAT5, B4GALT1",0.853871964321762,0.266802734893431,FALSE +"H1703","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.23261,-0.686,0.893,6762,0.98,"PDC, CNGB1, CAMK2D, PRKG1",0.0491485411114536,0.00877392430750515,FALSE +"H1703","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.36991,1.11,0.268,1729,0.908,"MTHFD1L, ATIC, GART, SHMT1",0.571865205971211,0.0419141514789149,FALSE +"H1703","Input","KEGG_OOCYTE_MEIOSIS",0.17911,0.541,0.995,2435,1,"CDC25C, PTTG1, YWHAH, RPS6KA1, ITPR2, YWHAE, PPP2R5D, BTRC, ESPL1, CDC26, PRKACA, RPS6KA2, FBXW11, YWHAG, MOS, YWHAQ, CAMK2G, MAPK12, YWHAB, CDK1, CALML3, ANAPC4",0.00217691925427455,0,FALSE +"H1703","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.31633,0.958,0.428,3060,0.9,"MAN2B2, AGA, HEXB, MAN2B1, HEXA",0.368556230986828,0.0457574905606751,FALSE +"H1703","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.36588,1.09,0.325,3387,0.848,"COX6A1, COX6C, LHPP, COX11, NDUFA4, COX7C, NDUFA11, COX15, NDUFA8, COX7A2, SDHA, SDHB, ATP5F1B, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, ATP5PD, UQCRQ, UQCRC1, NDUFA7, UQCRH, NDUFC1, NDUFB5, NDUFS5, NDUFA2, SDHD, NDUFB1, NDUFC2, COX5A, NDUFB10, NDUFS7, UQCRC2, ATP5PB, NDUFS8, NDUFV3, PPA1, ATP5F1D, COX7B, ATP5PF, UQCR10, ATP5ME",0.488116639021126,0.0716041477432862,FALSE +"H1703","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.73514,-2.16,0.00321,7562,0.131,"GALNT12, C1GALT1, B3GNT6, GALNT11, GALNT4, GALNT1, GALNT13, GALNT15, GALNT7, ST3GAL2, GALNT2, GCNT1, GALNT5, B4GALT5, GALNT3, GALNT6",2.49349496759513,0.882728704344236,TRUE +"H1703","Input","KEGG_P53_SIGNALING_PATHWAY",-0.28371,-0.84,0.636,7461,0.92,"CCNB2, CDK4, PMAIP1, TNFRSF10B, SFN, RCHY1, IGFBP3, THBS1, SERPINB5, CCND1, CDKN1A",0.196542884351586,0.0362121726544447,FALSE +"H1703","Input","KEGG_PANCREATIC_CANCER",-0.26446,-0.774,0.744,7005,0.922,"TP53, RAC3, RAD51, PIK3CA, TGFA, JAK1, CDK4, PIK3CB, TGFB3, TGFBR1, RALB, VEGFC, BCL2L1, PIK3R1, PIK3R2, VEGFA, PIK3CD, TGFB2, RAC2, CCND1",0.128427064454121,0.0352690789463706,FALSE +"H1703","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.23482,-0.686,0.854,2169,0.98,"PPCS, PPCDC, PANK2, DPYD, COASY, PANK4, BCAT2",0.068542129310995,0.00877392430750515,FALSE +"H1703","Input","KEGG_PARKINSONS_DISEASE",0.4569,1.37,0.121,3141,0.68,"UCHL1, UBE2G1, SLC18A1, COX6A1, UBE2L6, COX6C, NDUFA4, COX7C, NDUFA8, COX7A2, CASP9, SDHA, SDHB, ATP5F1B, UBE2L3, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, PPID, CYC1, COX4I1, PARK7, UQCRFS1, COX7A2L, COX6B1, LRRK2, ATP5PD, UQCRQ, UQCRC1, CASP3, NDUFA7, UQCRH, NDUFC1, NDUFB5, NDUFS5, CYCS, NDUFA2, SDHD, VDAC1, NDUFB1, NDUFC2, COX5A, NDUFB10, NDUFS7, UQCRC2, ATP5PB, NDUFS8, NDUFV3",0.91721462968355,0.167491087293764,FALSE +"H1703","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.33129,-0.974,0.442,8560,0.726,"ARPC1A, HCLS1, CTNNB1, TUBA4A, WAS",0.354577730650908,0.139063379299906,FALSE +"H1703","Input","KEGG_PATHWAYS_IN_CANCER",-0.24668,-0.731,0.797,7516,0.948,"SKP2, TPR, CDK4, RXRA, CTNNA2, PIK3CB, TGFB3, TGFBR1, RALB, APC, PAX8, VEGFC, ITGA6, HSP90B1, CTNNA1, BCL2L1, HRAS, MITF, PIK3R1, PDGFRB, CBLB, TRAF6, LAMB3, LAMC2, IL6, CTNNB1, PIK3R2, LAMA3, LAMA4, FN1, VEGFA, LAMB1, PIK3CD, MECOM, TGFB2, IGF1R, RAC2, ITGA2, MMP2, CCND1, RUNX1, SLC2A1, CDKN1A, PTGS2",0.0985416786038876,0.0231916626619338,FALSE +"H1703","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.3191,0.972,0.448,2088,0.89,"RPE, AKR1B1, CRYL1, XYLB",0.348721986001856,0.0506099933550872,FALSE +"H1703","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.27783,0.837,0.616,1399,0.972,"PGLS, DERA, PRPS1, PRPS1L1, PGD, RPE, PGM1",0.210419287835575,0.0123337350737254,FALSE +"H1703","Input","KEGG_PEROXISOME",-0.35685,-1.04,0.359,7236,0.645,"NUDT19, ACOX3, ACSL5, PEX11B, ACSL1, ACOX1, ACSL3, MLYCD, ABCD4, ACOT8, MVK, ACSL6, PXMP2, PEX12, AMACR, PEX13, ABCD3, CROT, ACOX2, CAT, CRAT, ACSL4, FAR1, EPHX2, SLC27A2",0.444905551421681,0.190440285364732,FALSE +"H1703","Input","KEGG_PHENYLALANINE_METABOLISM",-0.35798,-1.06,0.347,7974,0.638,"ALDH1A3, PAH, ALDH3A1, MAOA",0.459670525209126,0.195179321278838,FALSE +"H1703","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.26122,-0.788,0.72,7140,0.927,"PLCB4, PIK3CA, DGKZ, INPP5A, PIP4K2A, PIK3CB, ITPR3, PI4KA, ITPK1, PIP5K1C, PIK3R1, PIK3C2A, PIK3R2, DGKA, DGKB, PIK3CD, INPP5D",0.142667503568732,0.0329202658555029,FALSE +"H1703","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.61064,1.96,0.0073,1405,0.366,"HMOX1, FECH, UROS, BLVRA, HMBS, COX15, BLVRB, CP",2.13667713987954,0.436518914605589,FALSE +"H1703","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.5948,-1.77,0.0308,7193,0.253,"CPT2, ACOX3, ACSL5, ACSL1, ACOX1, ACSL3, GK, RXRA, PDPK1, ILK, ACSL6, SLC27A4, ACOX2, FABP1, ACSL4, FABP3, PCK1, CYP27A1, FABP2, LPL, HMGCS2, CD36, FADS2, APOC3, SLC27A2, FABP7, ME1",1.51144928349956,0.596879478824182,FALSE +"H1703","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.55766,-1.7,0.0375,7947,0.288,"AMACR, ACOX2, CYP27A1, AKR1D1",1.42596873227228,0.540607512240769,FALSE +"H1703","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.70651,2.18,0.0049,929,0.362,"CD40, TAP1, ADA, RFXAP, TAP2, RFXANK, IKBKG",2.30980391997149,0.441291429466834,FALSE +"H1703","Input","KEGG_PRION_DISEASES",-0.25636,-0.75,0.756,8198,0.925,"C9, IL6, NCAM1",0.121478204498793,0.0338582672609674,FALSE +"H1703","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.22266,-0.66,0.91,7461,0.975,"CCNB2, PIK3CB, GNAI1, BUB1, ADCY9, PIK3R1, MAPK13, PIK3R2, PIK3CD, IGF1R",0.0409586076789064,0.0109953843014632,FALSE +"H1703","Input","KEGG_PROPANOATE_METABOLISM",0.32583,1.01,0.403,387,0.9,"ALDH3A2, LDHB, ACACB, ACACA",0.39469495385889,0.0457574905606751,FALSE +"H1703","Input","KEGG_PROSTATE_CANCER",0.22788,0.703,0.859,587,0.974,"PDGFRA, GSTP1, ATF4, E2F3, PDGFC, RB1",0.0660068361687577,0.0114410431213845,FALSE +"H1703","Input","KEGG_PROTEASOME",0.26847,0.829,0.669,695,0.971,"PSMB9, SEM1, PSMB8, PSMB10",0.174573882232177,0.0127807700919951,FALSE +"H1703","Input","KEGG_PROTEIN_EXPORT",-0.36121,-1.06,0.336,6678,0.638,"SEC11A, SEC61A1, HSPA5, SPCS2, SPCS3, SEC11C, SPCS1",0.473660722610156,0.195179321278838,FALSE +"H1703","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.56241,-1.64,0.0609,8281,0.34,"ATP1A2, GLS, GLS2, PCK1, AQP1, SLC38A3",1.21538270736712,0.468521082957745,FALSE +"H1703","Input","KEGG_PURINE_METABOLISM",0.22486,0.692,0.867,2422,0.961,"PFAS, ADK, PDE6C, NME1, ADA, RRM2B, NUDT9, NUDT5, NT5C2, PRPS1, PRPS1L1, NME2, IMPDH2, NME3, ATIC, HPRT1, ADSL, GART, PAPSS2, DCK, POLD4, GMPS, PRPS2, GUK1, NUDT2, APRT, NME4, ITPA, NT5C, POLA2, FHIT, POLA1, POLR3G, PAICS",0.0619809025237897,0.0172766123314547,FALSE +"H1703","Input","KEGG_PYRIMIDINE_METABOLISM",0.21544,0.657,0.911,2369,0.994,"UPP1, TXNRD1, UPRT, NME1, RRM2B, NT5C2, NME2, NME3, DTYMK, CAD, DUT, DCK, DCTD, TK1, TK2, POLD4, NUDT2, NME4, ITPA, NT5C, POLA2, POLA1, POLR3G",0.0404816230270017,0.00261361560268669,FALSE +"H1703","Input","KEGG_PYRUVATE_METABOLISM",0.32341,0.983,0.425,1365,0.888,"ALDH3A2, LDHB, ACACB, ACACA, ME2, ACYP1, ACAT1, ACYP2, GLO1, AKR1B1",0.371611069949688,0.051587034221399,FALSE +"H1703","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.29383,-0.888,0.569,8034,0.835,"MYH14, HRAS, PIP5K1C, ITGA1, IQGAP3, ITGA4, PIK3R1, PDGFRB, ITGB6, ITGB4, RRAS2, ARPC1A, ITGA7, PIK3R2, IQGAP2, ACTN4, SLC9A1, FN1, SCIN, ITGB3, PIK3CD, RAC2, ITGA2, WAS, ITGB8",0.244887733604929,0.0783135245163979,FALSE +"H1703","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.44189,1.35,0.126,1681,0.676,"ATG12, ATG5, GABARAPL1, PIK3C3, ATG7, PIK3R4",0.899629454882437,0.170053304058364,FALSE +"H1703","Input","KEGG_RENAL_CELL_CARCINOMA",-0.25915,-0.769,0.748,6518,0.921,"JUN, HGF, SOS1, RAPGEF1, CREBBP, RAP1B, PIK3CA, MET, PAK4, TGFA, RAP1A, PIK3CB, TGFB3, VEGFC, HRAS, PIK3R1, PIK3R2, VEGFA, PIK3CD, TGFB2, SLC2A1",0.126098402135539,0.0357403698031511,FALSE +"H1703","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.39302,-1.14,0.293,7917,0.584,"MME, ACE, ANPEP",0.533132379645891,0.233587152887601,FALSE +"H1703","Input","KEGG_RETINOL_METABOLISM",-0.45263,-1.36,0.137,8665,0.524,"DGAT1, PNPLA4, DHRS3, RDH10",0.863279432843593,0.280668713016273,FALSE +"H1703","Input","KEGG_RIBOFLAVIN_METABOLISM",0.64005,1.97,0.0127,1663,0.532,"ACP6, PHPT1, MTMR6",1.89619627904404,0.274088367704952,FALSE +"H1703","Input","KEGG_RIBOSOME",0.12821,0.394,1,6734,1,"RPS4Y1, RPS29, RPL37, RPL38, RPS21, RPS12, RPS28, RPS3, RPL24, RSL24D1, RPS10, RPL17, RPL36A, RPL36AL, UBA52, RPS5, RPSA, RPS19, RPL10A, FAU, RPL18, RPL12, RPL13A, RPL29, RPS17, RPL35A, RPS15A, RPS15, RPL23, RPS27L, RPL30, RPLP0, RPS9, RPS13, RPL9, RPL22, RPL18A, RPS16, RPS2, RPL3, RPLP1, RPS20, RPL28, RPS24, RPL10, RPL15, RPL6, RPL11, RPL27, RPL7A, RPL4, RPS11, RPL8, RPL26, RPS27A, RPL31, RPL7, RPL34, RPS4X, RPLP2, RPS25, RPL36, RPS23, RPL27A, RPS7, RPL23A, RPS18, RPS8, RPS26, RPL21, MRPL13, RPL13, RPL26L1, RPS3A, RPL5, RPL19, RPL35, RPL37A, RPL32",0,0,FALSE +"H1703","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.45927,1.38,0.106,2218,0.713,"DDX3Y, AZI2, ATG12, TBKBP1, MAPK9, RIPK1, MAPK10, IKBKG, NFKBIB, RELA, MAP3K7, ATG5, MAPK8, TBK1, DHX58, TANK, TRAF2, SIKE1, IRF3, TRADD, MAPK12",0.97469413473523,0.146910470148134,FALSE +"H1703","Input","KEGG_RNA_DEGRADATION",0.1837,0.565,0.98,1959,1,"LSM1, ENO1, DCP1B, ENO3, HSPA9, XRN1, LSM6, DCP2, LSM2, LSM7, LSM3",0.00877392430750515,0,FALSE +"H1703","Input","KEGG_RNA_POLYMERASE",-0.42494,-1.25,0.19,5770,0.584,"POLR2B, POLR3C, POLR2I, POLR2E, POLR2D, POLR2L, POLR1E, POLR2F, POLR3D, POLR3H, POLR3A, POLR3K, POLR3B",0.721246399047171,0.233587152887601,FALSE +"H1703","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.38246,-1.12,0.29,8174,0.611,"GGT7, GGT5, MARS2, CTH",0.537602002101044,0.213958789757446,FALSE +"H1703","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.42096,-1.25,0.163,7516,0.584,"SKP2, CDK4, RXRA, PIK3CB, ITGA6, BCL2L1, PIK3R1, TRAF6, LAMB3, LAMC2, PIK3R2, LAMA3, LAMA4, FN1, LAMB1, PIK3CD, ITGA2, CCND1, PTGS2",0.787812395596042,0.233587152887601,FALSE +"H1703","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.54227,-1.59,0.0606,7091,0.325,"STX12, STX16, GOSR1, VTI1A, STX5, VAMP4, STX10, STX18, SEC22B, SNAP23, STX3, BET1L, VAMP5, VAMP8",1.21752737583371,0.488116639021126,FALSE +"H1703","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.2792,-0.812,0.667,8252,0.921,"SMPD1, ASAH1, PLPP3, SMPD3",0.175874166083451,0.0357403698031511,FALSE +"H1703","Input","KEGG_SPLICEOSOME",0.3247,0.985,0.433,3774,0.909,"WBP11, PQBP1, ZMAT2, LSM6, SF3B4, SLU7, RBM8A, DHX8, CHERP, LSM2, PPIL1, LSM7, LSM3, HSPA1A, SNW1, LSM4, SMNDC1, HSPA6, SNRNP40, ACIN1, SF3A2, HSPA2, PRPF8, CDC40, SNRNP70, SRSF5, CWC15, ISY1, THOC2, SYF2, THOC1, AQR, MAGOHB, TCERG1, U2AF1, SNRNP27, U2AF2, TXNL4A, HNRNPC, SNRPC, PPIH, ALYREF, HSPA1L, RBMX, THOC3, EFTUD2, CCDC12, PPIE, RBM17, SNRPG, SART1, BUD31, SRSF9, SNRPF, HSPA8, DDX23, BCAS2, PRPF3, SRSF2, SRSF1, LSM8",0.363512103646635,0.0414361167780325,FALSE +"H1703","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.32918,-0.966,0.47,5743,0.701,"GCK, HK2, PYGB, GBE1, AGL, GAA, PGM2, HK3, GYS1, UXS1, MGAM, UGDH, PGM2L1",0.327902142064283,0.154281982033341,FALSE +"H1703","Input","KEGG_STEROID_BIOSYNTHESIS",-0.64893,-1.88,0.0186,7678,0.204,"SC5D, LSS, DHCR7, HSD17B7, DHCR24, SQLE, MSMO1, CYP51A1, FDFT1, TM7SF2",1.73048705578208,0.690369832574101,TRUE +"H1703","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.70082,-2.05,0.00338,6972,0.127,"HSD11B2, SRD5A3, AKR1C3, STS, HSD17B7, AKR1C1, HSD17B12, CYP21A2, AKR1D1, HSD17B8",2.47108329972235,0.896196279044043,TRUE +"H1703","Input","KEGG_SULFUR_METABOLISM",-0.35586,-1.06,0.343,8090,0.638,"CHST11, SULT1A3",0.464705879957229,0.195179321278838,FALSE +"H1703","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.41474,1.29,0.177,14,0.716,"CD40",0.752026733638193,0.145086977692144,FALSE +"H1703","Input","KEGG_TASTE_TRANSDUCTION",-0.32505,-0.968,0.461,7312,0.708,"GNB1, GNB3, GNAS, ITPR3",0.336299074610352,0.149966742310231,FALSE +"H1703","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.36951,-1.1,0.315,7734,0.615,"MVK, HMGCR, HMGCS1, HMGCS2",0.501689446210399,0.211124884224583,FALSE +"H1703","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.20776,0.647,0.935,1281,0.975,"TGFBR2, ZFYVE16, E2F5, RPS6KB1, TGFB1, AMH, SMAD4",0.0291883891274822,0.0109953843014632,FALSE +"H1703","Input","KEGG_THYROID_CANCER",-0.40355,-1.18,0.225,7005,0.57,"TP53, MYC, TCF7L2, TPR, RXRA, PAX8, HRAS, CTNNB1, CCND1",0.647817481888638,0.244125144327509,FALSE +"H1703","Input","KEGG_TIGHT_JUNCTION",-0.34659,-1.01,0.402,7360,0.673,"PPP2R2A, PRKCD, PPP2R2B, CDK4, RAB3B, PRKCI, CTNNA2, JAM2, GNAI1, PARD6B, CTNNA1, CASK, MYH14, MYH7B, HRAS, SPTAN1, PARD6G, RRAS2, CLDN7, HCLS1, CTNNB1, ACTN4, CLDN3, LLGL2, TJP2, EPB41L3, EPB41L1, F11R",0.39577394691553,0.171984935776023,FALSE +"H1703","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.28064,0.847,0.605,1854,0.991,"CD40, TLR3, CTSK, MAPK9, RIPK1, MAP2K4, MAPK10, IKBKG, MYD88, RELA, MAP3K7, MAPK8, TAB2, TAB1, TBK1",0.218244625347531,0.00392634551472468,FALSE +"H1703","Input","KEGG_TRYPTOPHAN_METABOLISM",0.45205,1.4,0.115,325,0.799,"KYNU, ALDH3A2, MAOB",0.939302159646388,0.0974532206860086,FALSE +"H1703","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.38145,-1.14,0.274,6958,0.584,"HK3, PIK3CA, PKM, PRKCD, IRS2, PIK3CB, PDX1, PIK3R1, IRS1, PIK3R2, PIK3CD",0.562249437179612,0.233587152887601,FALSE +"H1703","Input","KEGG_TYROSINE_METABOLISM",0.335,1.03,0.38,2077,0.981,"MAOB, FAH, PNMT, GSTZ1, MIF, ADH5, GOT1, LCMT1, DCT",0.42021640338319,0.0083309926200515,FALSE +"H1703","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.2842,-0.848,0.627,7033,0.914,"PTPN6, PPP3R1, PIK3CA, PAK4, TEC, PPP3CA, PPP3CC, CDK4, PIK3CB, MAP2K7, PDPK1, VAV3, PTPRC, HRAS, PIK3R1, CBLB, DLG1, MAPK13, LCP2, PIK3R2, PIK3CD, NFATC4",0.202732459169284,0.0390538042661686,FALSE +"H1703","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.25608,0.791,0.703,2750,0.923,"FBXO2, HERC4, VHL, UBE2G1, UBE2L6, FBXW7, ERCC8, XIAP, UBE2E1, UBE2R2, CUL4B, BIRC6, BTRC, UBE2K, UBE2L3, UBE2E2, CDC26, NEDD4L, CUL4A, CUL3, UBE3B, UBE2A, UBE2M, UBE2D4, FBXW11, PIAS4, FBXW8, CUL7, UBE2D2, SMURF2, ANAPC4, PIAS2, SAE1, NEDD4, UBE2H, SKP1, ELOB, UBA6, CUL1",0.153044674980176,0.0347982989740879,FALSE +"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.26856,-0.782,0.703,2481,0.917,"VARS2, IARS2, PDHB, PDHA1, LARS2, BCAT2",0.153044674980176,0.0376306643299789,FALSE +"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.33257,-0.97,0.425,7790,0.714,"BCAT2, HMGCS1, HIBCH, DBT, ABAT, HMGCS2, ALDH6A1, ACADS",0.371611069949688,0.146301788223826,FALSE +"H1703","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.21836,-0.641,0.912,7041,0.987,"PLA2G12A, PLCB4, MYLK3, ARHGEF12, GNA12, GUCY1A1, PRKCD, MYLK, GNA11, GNAS, PLA2G4A, ITPR3, PPP1R12B, ADCY9, PRKG1",0.0400051616715838,0.00568284733036327,FALSE +"H1703","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.33192,1.02,0.385,1667,0.937,"DYNC1I2, DYNC1I1, DYNC1LI1, DCTN6, DCTN5, DYNC1LI2, DCTN4, DYNC1H1, DYNC2LI1, DCTN2, PRKACA",0.414539270491499,0.0282604091122217,FALSE +"H1703","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.41155,-1.23,0.207,7041,0.589,"PLA2G12A, PTK2, RAC3, PPP3R1, PIK3CA, PPP3CA, PPP3CC, PIK3CB, PLA2G4A, HRAS, PIK3R1, MAPK13, PIK3R2, VEGFA, PIK3CD, RAC2, NFATC4, PTGS2",0.684029654543082,0.229884705212898,FALSE +"H1703","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.43289,-1.27,0.187,6031,0.579,"ATP6V1F, SLC12A2, SEC61B, ATP6V1E1, TJP1, ATP6V1A, ATP6V1C2, SEC61A1, ATP6V0A2, ATP6V0C, ATP6V1B2, ATP6V0D1, ATP6V1G2, TCIRG1, ATP6V1D, ATP6V1B1, ATP6V1H, GNAS, PDIA4, ERO1A, ADCY9, TJP2",0.728158393463501,0.237321436272564,FALSE +"H1703","Input","KEGG_VIRAL_MYOCARDITIS",0.33545,1.01,0.403,1754,0.9,"CD40, CAV1, CXADR, MYH3, CASP9, SGCB, BID, DAG1, MYH10, MYH11, MYH9",0.39469495385889,0.0457574905606751,FALSE +"H1703","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.26004,-0.784,0.741,6430,0.923,"PPP2R5B, PPP2R1B, TBL1XR1, TCF7L1, JUN, CTBP2, VANGL1, CSNK1A1, PPP2R5E, CREBBP, DVL3, TP53, DVL1, RAC3, PPP3R1, MYC, PLCB4, WNT5A, PPP2CB, TCF7L2, CCND3, PPP3CA, TBL1X, PPP3CC, CAMK2D, APC, CSNK1E, FOSL1, SOX17, PPP2R5C, SENP2, DAAM1, CTNNB1, RAC2, NFATC4, CCND1",0.130181792020672,0.0347982989740879,FALSE +"H460","Input","KEGG_ABC_TRANSPORTERS",0.55065,1.81,0.0299,931,0.205,"ABCG2, ABCC2, ABCC3, ABCB6, ABCB10, ABCD4, ABCG1, ABCA3",1.52432881167557,0.688246138944246,TRUE +"H460","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.53944,-1.7,0.0332,6979,0.463,"MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, IKBKB, RPS6KB2, TCF7L2, MAPK1, RARA, PIK3R2, RAF1, RELA, STAT5A, MAPK3, RPS6KB1, AKT2, STAT5B, EIF4EBP1, STAT3",1.47886191629596,0.334419008982047,FALSE +"H460","Input","KEGG_ADHERENS_JUNCTION",-0.24556,-0.781,0.715,6894,0.831,"FER, FARP2, PTPN1, RHOA, VCL, CDH1, CDC42, TCF7L2, LMO7, MAPK1, NLK, PTPRF, MAPK3, RAC2, BAIAP2, WASL, NECTIN4, PTPN6",0.145693958198919,0.080398976215889,FALSE +"H460","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.29557,-0.966,0.457,5653,0.604,"NFKBIB, PRKAA1, NFKB1, RXRA, MTOR, ACSL3, CAMKK2, AKT3, CHUK, PRKAG1, CPT1A, PTPN11, RXRB, PRKAG2, RXRG, AKT1, PRKCQ, STK11, IKBKB, CD36, RELA, ACACB, AKT2, IRS1, STAT3",0.34008379993015,0.218963061378868,FALSE +"H460","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.26943,0.837,0.606,1174,0.786,"CPS1, GLS, GLS2, GPT2",0.217527375833714,0.104577453960592,FALSE +"H460","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.30467,-1,0.426,6398,0.57,"KRAS, ATP1A4, ATP1A1, ATP1A3, NEDD4L, PIK3CA, PIK3CB, MAPK1, PIK3R2, MAPK3, IRS1",0.370590400897281,0.244125144327509,FALSE +"H460","Input","KEGG_ALZHEIMERS_DISEASE",0.41924,1.38,0.102,2562,0.387,"ATP5PF, ITPR1, NDUFS6, ATP5PD, HSD17B10, UQCRH, CASP7, ATP5F1D, PLCB4, NDUFA2, NDUFS8, SNCA, NDUFA8, TNFRSF1A, NDUFV2, UQCRFS1, UQCRB, NDUFS4, ATP5F1B, APP, NDUFA7, COX5B, COX6B1, COX6A1, NDUFS1, UQCRC1, NDUFA5, ADAM17, NDUFA3, NCSTN, ERN1, CYCS, NDUFV3, SDHB, COX5A, CYC1, NDUFS3, CALM2, NDUFB8, ATP5F1E, ATP5PB, GNAQ, SDHA, NDUFB2, UQCRC2, COX7A2, NDUFA4, COX7C, NDUFV1, ATP5MC2, UQCR10, SDHC, NDUFS5, NDUFAB1, NDUFB3, NDUFC1, ADAM10, ATP5F1A, ATP5PO, LRP1, NDUFB6, NDUFA4L2",0.991399828238082,0.412289034981089,FALSE +"H460","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.37902,-1.22,0.222,4549,0.447,"YARS2, HARS2, MARS2, CARS2, NARS2, SARS2, WARS2, MTFMT, FARSB, TARS2, PARS2, VARS2, FARSA, SEPSECS",0.653647025549361,0.349692476868064,FALSE +"H460","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.48321,-1.55,0.0709,6657,0.399,"PMM1, HK2, GMDS, PGM2, UGP2, MPI, NAGK, NANP, GNPDA1, GPI, HK1, AMDHD2, FPGT, GNPNAT1, GALT, GALE, RENBP, PGM3, PGM1, UAP1",1.14935376481693,0.399027104313252,FALSE +"H460","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.33907,-1.09,0.299,7391,0.513,"CAT, GRIN1, DAXX, PPP3CA, MAPK14, APAF1, CASP1, PPP3CB, MAPK13, MAPK12",0.52432881167557,0.289882634888184,FALSE +"H460","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.33315,1.08,0.346,1319,0.602,"CTSL, B2M, HSPA5, PDIA3, NFYB, CTSB, RFXANK",0.460923901207223,0.220403508742175,FALSE +"H460","Input","KEGG_APOPTOSIS",-0.23443,-0.744,0.807,7393,0.841,"PIK3CB, AKT1, IRAK4, CASP6, IKBKB, PPP3CA, RIPK1, CAPN2, PIK3R2, RELA, APAF1, PPP3CB, AKT2, CAPN1",0.0931264652779296,0.0752040042020878,FALSE +"H460","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.34082,1.08,0.35,419,0.602,"GGT1, AKR1C3, PTGES",0.455931955649724,0.220403508742175,FALSE +"H460","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.30204,-0.966,0.436,7377,0.604,"AMD1, SMS, ASL, CKMT1A, PRODH, PRODH2, CKB, ARG2, ARG1, GATM, AOC1, DAO, GLUD2",0.360513510731414,0.218963061378868,FALSE +"H460","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.41446,1.31,0.148,1073,0.41,"CACNA2D1, ITGB5, DSC2, ITGAV, ITGA5, DES, LMNA, DAG1, DSG2, SGCD, ITGA6",0.829738284605043,0.387216143280265,FALSE +"H460","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.7103,2.29,0.00211,230,0.0879,"UGDH",2.67571754470231,1.05601112492623,TRUE +"H460","Input","KEGG_AXON_GUIDANCE",-0.37722,-1.21,0.217,7073,0.434,"PLXNC1, PAK3, ROCK1, NFATC3, RHOA, EPHA2, PAK1, PTK2, CDK5, ROCK2, PAK4, GSK3B, CFL1, ARHGEF12, CDC42, PPP3CA, NFAT5, RASA1, EFNB2, MAPK1, SLIT2, ABLIM1, PAK2, SEMA3C, MAPK3, RAC2, EPHB3, PPP3CB, NTN1, RHOD, NGEF, NFATC2, EPHB2",0.66354026615147,0.362510270487489,FALSE +"H460","Input","KEGG_BASAL_CELL_CARCINOMA",-0.22181,-0.722,0.811,6274,0.849,"FZD7, CTNNB1, STK36, GSK3B, DVL3, TCF7L2",0.090979145788844,0.0710923097560473,FALSE +"H460","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.36423,1.18,0.228,2507,0.51,"TAF13, GTF2A2, TAF12, TAF10, GTF2E2, GTF2A1, TAF5L, GTF2H1, TAF1, TAF6L, TAF6, TAF9, TAF4, TAF7, GTF2F2",0.642065152999546,0.292429823902064,FALSE +"H460","Input","KEGG_BASE_EXCISION_REPAIR",0.19161,0.627,0.924,7077,0.96,"NTHL1, TDG, PARP2, POLD4, LIG3, PARP1, POLE3, XRCC1, MPG, POLD2, POLE4, POLB, FEN1, PCNA, POLD1, APEX1, POLD3, PARP4, MBD4, POLE, LIG1, UNG, HMGB1",0.0343280287798933,0.0177287669604316,FALSE +"H460","Input","KEGG_BETA_ALANINE_METABOLISM",-0.29499,-0.961,0.453,6104,0.597,"MLYCD, ABAT, EHHADH, SMS, DPYD",0.343901797987168,0.224025668870631,FALSE +"H460","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.22426,-0.724,0.806,7093,0.863,"HACD2, TECR, ACOT7",0.0936649581949093,0.0639892042847904,FALSE +"H460","Input","KEGG_BLADDER_CANCER",-0.34042,-1.1,0.305,6398,0.505,"KRAS, NRAS, MAP2K2, CDK4, MAP2K1, CDH1, THBS1, MAPK1, DAPK1, RAF1, MAPK3",0.515700160653214,0.296708621881339,FALSE +"H460","Input","KEGG_BUTANOATE_METABOLISM",-0.3324,-1.07,0.353,7112,0.528,"AACS, EHHADH, BDH2, ACAT2, HMGCS2, ACSM3, HMGCS1, BDH1",0.452225294612177,0.277366077466188,FALSE +"H460","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.52543,-1.7,0.0518,6194,0.463,"AKT3, CHUK, KRAS, NRAS, BCL10, RAC1, MAP2K2, NFATC3, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, IKBKB, PPP3CA, NFAT5, PLCG2, MAPK1, SYK, PIK3R2, RAF1, RELA, MAPK3, RAC2, VAV2, PPP3CB, AKT2, PTPN6, NFATC2",1.28567024025477,0.334419008982047,FALSE +"H460","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.28594,0.925,0.524,1201,0.762,"BST1, CACNA1A, ITPR1, CAMK2D, PLCB4, CAMK4, PLCD3, PRKCB, VDAC1, RYR1, PTK2B, ATP2B1",0.280668713016273,0.1180450286604,FALSE +"H460","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.45636,1.47,0.111,2271,0.331,"CACNA2D1, UQCRH, UQCRFS1, UQCRB, ATP1A2, COX5B, COX6B1, COX6A1, UQCRC1, COX5A, CYC1, SLC8A1, UQCRC2, TPM4, COX7A2, COX7C, TPM3, TPM1, UQCR10",0.954677021213343,0.480172006224281,FALSE +"H460","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.56014,1.85,0.0274,456,0.224,"SDC2, NRCAM, PTPRM, CD274, NCAM2, NCAM1, CD99, L1CAM, CNTN1, PDCD1LG2, JAM3, ITGAV, CD58",1.56224943717961,0.649751981665837,TRUE +"H460","Input","KEGG_CELL_CYCLE",-0.23427,-0.75,0.778,6113,0.839,"SMAD3, TFDP1, ORC2, ANAPC4, PRKDC, BUB1B, STAG2, RBL1, HDAC1, ABL1, BUB1, PLK1, CUL1, SMC3, CDK4, YWHAB, CDC45, STAG1, GSK3B, YWHAZ, FZR1, CHEK1, CDC23, CDC16, CDK1, CCNA2, CDK2, CCNB1, TTK, PTTG1, WEE1",0.109020403010311,0.0762380391712997,FALSE +"H460","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.41158,-1.29,0.179,6982,0.43,"HCK, GNG4, ROCK1, GRK6, MAP2K1, RHOA, PIK3CA, PAK1, SOS1, PTK2, ROCK2, PIK3CB, AKT1, GSK3B, PXN, IKBKB, CDC42, MAPK1, BCAR1, CCL15, PIK3R2, RAF1, RELA, CSK, MAPK3, RAC2, STAT1, VAV2, CCL13, GRK2, GSK3A, PRKCD, WASL, GNG5, AKT2, STAT5B, ARRB1, CCL14, STAT2, STAT3",0.747146969020107,0.366531544420413,FALSE +"H460","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.31495,-1.02,0.352,5735,0.552,"PIK3CD, CBL, NFKB1, TGFBR2, SMAD3, AKT3, CHUK, CBLB, KRAS, NRAS, CRKL, HDAC1, ABL1, MAP2K2, PTPN11, CDK4, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, IKBKB, MECOM, MAPK1, PIK3R2, RAF1, RELA, STAT5A, MAPK3, AKT2, STAT5B",0.453457336521869,0.258060922270801,FALSE +"H460","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.41577,1.37,0.13,2298,0.382,"PDHB, IDH3A, MDH2, SUCLG1, SUCLG2, PDHA1, SDHB, DLAT, DLST, PCK2, DLD, SDHA, ACO2, IDH3G, SDHC",0.886056647693163,0.417936637088291,FALSE +"H460","Input","KEGG_COLORECTAL_CANCER",-0.21976,-0.722,0.82,7147,0.849,"MAP2K1, RHOA, PIK3CA, PIK3CB, AKT1, GSK3B, TCF7L2, MAPK1, PIK3R2, RAF1, MAPK3, RAC2, AKT2",0.0861861476162833,0.0710923097560473,FALSE +"H460","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.41555,1.35,0.157,1265,0.389,"CD55, MBL2, PLAUR, F3, C9, F5, F8, PROS1, PLAU, C7",0.804100347590766,0.410050398674292,FALSE +"H460","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.3892,-1.27,0.167,5302,0.435,"SRM, APIP, AHCYL1, LDHB, LDHA, ENOPH1, DNMT1, GOT1, AMD1, SMS, CBS, ADI1, SDS, AHCY",0.777283528852417,0.361510743045363,FALSE +"H460","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.37916,1.24,0.184,618,0.463,"EPO, CXCL5, TNFRSF19, TNFRSF10A, TGFB2, TGFBR1, TNFRSF10B, TNFRSF1A, OSMR, CXCL6",0.735182176990464,0.334419008982047,FALSE +"H460","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.24465,-0.781,0.723,7666,0.831,"IKBKB, PYCARD, RIPK1, RELA, ZBP1, CASP1, IL18",0.140861702705469,0.080398976215889,FALSE +"H460","Input","KEGG_DILATED_CARDIOMYOPATHY",0.42515,1.39,0.123,2322,0.391,"CACNA2D1, TGFB2, ITGB5, ITGAV, ITGA5, DES, LMNA, DAG1, SGCD, ITGA6, ITGA10, ACTG1, SLC8A1, TGFB1, EMD, ITGB1, TPM4, TPM3, GNAS, TPM1, ACTB",0.910094888560602,0.407823242604133,FALSE +"H460","Input","KEGG_DNA_REPLICATION",-0.19803,-0.656,0.924,4819,0.913,"POLD1, MCM2, RNASEH2B, MCM7, POLA1, POLD3, MCM4, MCM6, RNASEH1, PRIM1, POLE, RFC4, RFC2, LIG1, RFC3, RFC1, RFC5",0.0343280287798933,0.039529222465701,FALSE +"H460","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.29715,0.945,0.454,1003,0.753,"NOTCH3, NOTCH1, NOTCH2",0.342944147142896,0.123205023799299,FALSE +"H460","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.39322,1.28,0.165,1773,0.436,"MGST1, GSTM4, GSTM1, ALDH3A1, GSTM2, MGST2, MAOA, ADH4, ADH7, GSTK1",0.782516055786094,0.360513510731414,FALSE +"H460","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.43429,-1.4,0.12,7379,0.461,"UPP1, HPRT1, NAT1, TK1, TK2, DPYD, TPMT, UCKL1",0.920818753952375,0.336299074610352,FALSE +"H460","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.55457,1.8,0.0184,818,0.192,"SDC2, COL5A2, FN1, SPP1, LAMB1, HSPG2, LAMA1, LAMC1, ITGB5, LAMA5, ITGAV, ITGA5, VTN, LAMB2, THBS3, DAG1, COL6A1, COL4A6",1.73518217699046,0.71669877129645,TRUE +"H460","Input","KEGG_ENDOCYTOSIS",-0.34822,-1.12,0.27,6029,0.507,"HSPA1A, DNM2, CHMP3, VPS4B, GIT2, VPS28, RAB5A, PARD6G, CBLB, SMAP2, IQSEC2, ARFGAP1, ARFGAP3, CHMP4A, CHMP4B, VPS25, CHMP4C, VPS37B, PIP5K1A, NEDD4L, EPS15, VTA1, RAB11A, SH3GL1, ITCH, GRK6, EHD1, EHD2, DAB2, RAB11FIP1, TRAF6, ARAP1, WWP1, IQSEC1, PDCD6IP, RAB5C, SH3GLB2, CDC42, ACAP2, SH3GLB1, CHMP2A, FGFR2, CLTC, ASAP1, SMURF2, EHD3, CHMP5, SMAP1, DNM1, LDLRAP1, CHMP2B, GRK2, ERBB3, PRKCI, ARFGAP2, ARRB1, ARAP3, DNM1L",0.568636235841013,0.294992040666664,FALSE +"H460","Input","KEGG_ENDOMETRIAL_CANCER",-0.3979,-1.29,0.163,6194,0.43,"AKT3, CTNNB1, KRAS, NRAS, MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, CDH1, TCF7L2, MAPK1, PIK3R2, RAF1, MAPK3, AKT2",0.787812395596042,0.366531544420413,FALSE +"H460","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.31666,-1.02,0.38,7666,0.552,"IKBKB, CDC42, PLCG2, F11R, PLCG1, MAPK14, RELA, CSK, MAPK13, MAP2K4, MAPK12",0.42021640338319,0.258060922270801,FALSE +"H460","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.42375,-1.4,0.113,6979,0.461,"MAP2K2, PAK3, MAP2K1, PIK3CA, PAK1, SOS1, PTK2, PAK4, PIK3CB, AKT1, GSK3B, GAB1, RPS6KB2, PLCG2, MAPK1, PLCG1, PAK2, PIK3R2, RAF1, STAT5A, MAPK3, RPS6KB1, ERBB3, AKT2, STAT5B, EIF4EBP1, MAP2K4, TGFA, ABL2",0.94692155651658,0.336299074610352,FALSE +"H460","Input","KEGG_ETHER_LIPID_METABOLISM",-0.23858,-0.761,0.742,7332,0.838,"PAFAH1B3, LPCAT4, PAFAH2, LPCAT2",0.129596094720973,0.0767559813697235,FALSE +"H460","Input","KEGG_FATTY_ACID_METABOLISM",0.25942,0.813,0.657,1769,0.804,"ACAA2, ACADSB, ECHS1, ACADS, ECI1, ACAT1, ADH4, ADH7",0.182434630440219,0.0947439512515487,FALSE +"H460","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.48251,-1.57,0.0503,6979,0.393,"MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, PLCG2, MAPK1, PLCG1, SYK, MAPK14, PIK3R2, RAF1, MAPK3, RAC2, VAV2, PRKCD, AKT2, MAPK13, MAP2K4, MAPK12",1.29843201494407,0.405607449624573,FALSE +"H460","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.50299,-1.63,0.0526,6982,0.36,"HCK, ARPC1A, MAP2K1, PIK3CA, PAK1, PIK3CB, AKT1, ARPC4, ARPC3, CFL1, VASP, CDC42, RPS6KB2, PLCG2, SCIN, ARPC2, MAPK1, MYO10, PLCG1, SYK, PIK3R2, RAF1, ASAP1, MARCKSL1, MAPK3, RAC2, VAV2, GSN, DNM1, RPS6KB1, PRKCD, WASL, AKT2, PTPRC, MARCKS, DNM1L",1.27901425584626,0.443697499232713,FALSE +"H460","Input","KEGG_FOCAL_ADHESION",0.27835,0.89,0.537,472,0.741,"COL5A2, FN1, SPP1, LAMB1, PIK3R3, LAMA1, LAMC1, ITGB5, LAMA5, FLNB, ITGAV, ITGA5, VTN, CAV2, LAMB2, THBS3",0.270025714300444,0.130181792020672,FALSE +"H460","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.51655,-1.67,0.0544,7763,0.424,"DHFR, ALPG, ALPI, ALPP",1.26440110030182,0.372634143407267,FALSE +"H460","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.4599,-1.48,0.107,6110,0.435,"MTMR1, ALDOC, PFKFB3, PFKP, PMM1, HK2, TPI1, GMDS, PFKM, MTMR6, MPI, HK1, FPGT, PFKFB2, PFKFB4, PFKL, FBP1",0.97061622231479,0.361510743045363,FALSE +"H460","Input","KEGG_GALACTOSE_METABOLISM",-0.41733,-1.32,0.162,6503,0.432,"PFKP, HK2, PFKM, PGM2, UGP2, MGAM, HK1, GALT, GALE, PGM1, PFKL",0.790484985457369,0.364516253185088,FALSE +"H460","Input","KEGG_GAP_JUNCTION",-0.3032,-0.982,0.423,5952,0.592,"ADCY5, TUBB4B, HTR2B, GNAI3, TUBB6, KRAS, NRAS, PRKACB, PLCB3, MAPK7, MAP2K2, MAP2K1, SOS1, TUBA1B, TUBB3, TUBB1, TUBB, MAPK1, TUBB2A, RAF1, CDK1, MAPK3, CSNK1D, TUBA1C",0.373659632624958,0.22767829327708,FALSE +"H460","Input","KEGG_GLIOMA",-0.34386,-1.11,0.303,6979,0.506,"MAP2K2, CDK4, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, PLCG2, MAPK1, PLCG1, PIK3R2, RAF1, MAPK3, AKT2, TGFA",0.518557371497695,0.295849483160201,FALSE +"H460","Input","KEGG_GLUTATHIONE_METABOLISM",0.24851,0.8,0.7,331,0.801,"MGST1, GGT1, GSTM4, GSTM1",0.154901959985743,0.0963674839157623,FALSE +"H460","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.28815,-0.932,0.509,8160,0.64,"DGKA, MGLL, DGKH",0.293282217663241,0.193820026016113,FALSE +"H460","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.34491,-1.12,0.292,7585,0.507,"LPCAT4, MBOAT2, MBOAT7, CHKB, DGKA, PCYT2, PEMT, LPCAT2, CHKA, DGKH",0.534617148551582,0.294992040666664,FALSE +"H460","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.32315,-1.04,0.357,6143,0.553,"PSPH, SARDH, DMGDH, SRR, SHMT1, CBS, SDS, GATM, DAO",0.447331783887807,0.257274868695302,FALSE +"H460","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.41707,-1.37,0.122,6301,0.472,"ALDOC, LDHA, GALM, PFKP, BPGM, HK2, PGAM1, PGAM4, TPI1, AKR1A1, PFKM, ADH5, PGM2, ACSS2, GPI, HK1, ADH1C, ALDH1A3, PKLR, PGM1, PFKL, FBP1, PKM",0.913640169325252,0.326058001365912,FALSE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.2905,0.935,0.54,6210,0.758,"CHPF2, CHST3, DSE, CHSY1, B3GAT3, CHPF, B4GALT7, XYLT2, B3GALT6",0.267606240177031,0.120330794367946,FALSE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.36162,-1.16,0.242,5838,0.472,"XYLT2, B3GALT6, EXTL3, NDST2, HS2ST1",0.616184634019569,0.326058001365912,FALSE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.26235,0.87,0.589,380,0.737,"ST3GAL2",0.229884705212898,0.132532512140949,FALSE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.70444,2.3,0,2263,0.168,"GNS, IDS, HEXB, HEXA, GLB1, ARSB, GUSB, IDUA, GALNS",Inf,0.774690718274137,TRUE +"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.64575,2.05,0.0131,970,0.132,"B4GALNT1, ST3GAL2, HEXB, HEXA",1.88272870434424,0.87942606879415,TRUE +"H460","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.50746,-1.66,0.0396,5131,0.372,"PIGK, PIGT, GPAA1, PGAP1, PIGQ, PIGH, PIGM, PIGU",1.40230481407449,0.429457060118102,FALSE +"H460","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.23526,0.766,0.757,2095,0.849,"MTHFD2, MDH2, HAO1, ACO2",0.120904120499927,0.0710923097560473,FALSE +"H460","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.32237,-1.03,0.362,6398,0.56,"KRAS, NRAS, MAP3K3, PRKACB, PLCB3, MAPK7, MAP2K2, MAP2K1, SOS1, CDC42, MAPK1, MMP14, MAP3K4, MAPK14, RAF1, MAPK3, PRKCD, MAPK13, MAP2K4, MAPK12, MAP3K1",0.441291429466834,0.2518119729938,FALSE +"H460","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.33353,-1.06,0.341,7225,0.536,"STK36, GSK3B, CSNK1G2, BTRC, CSNK1A1, CSNK1D",0.467245621007502,0.27083521030723,FALSE +"H460","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.41187,1.33,0.13,454,0.399,"CD55, EPO, ITGA5, CD14",0.886056647693163,0.399027104313252,FALSE +"H460","Input","KEGG_HISTIDINE_METABOLISM",-0.40967,-1.33,0.146,7838,0.43,"TRMT11, METTL2B, LCMT1, ALDH1A3, HDC, AOC1",0.835647144215563,0.366531544420413,FALSE +"H460","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.31013,1.02,0.375,2061,0.684,"SSBP1, RAD51, RAD54L, MUS81, POLD4, MRE11",0.425968732272281,0.164943898279884,FALSE +"H460","Input","KEGG_HUNTINGTONS_DISEASE",0.4545,1.48,0.0838,2579,0.338,"ATP5PF, ITPR1, NDUFS6, ATP5PD, UQCRH, ATP5F1D, PLCB4, NDUFA2, NDUFS8, POLR2H, NDUFA8, CLTA, SOD2, NDUFV2, UQCRFS1, UQCRB, NDUFS4, ATP5F1B, POLR2C, NDUFA7, COX5B, COX6B1, VDAC1, CLTB, COX6A1, POLR2L, NDUFS1, POLR2D, UQCRC1, NDUFA5, NDUFA3, POLR2E, CYCS, NDUFV3, SDHB, COX5A, CYC1, NDUFS3, AP2A2, NDUFB8, ATP5F1E, POLR2I, ATP5PB, GNAQ, POLR2F, SDHA, NDUFB2, UQCRC2, COX7A2, POLR2G, NDUFA4, COX7C, AP2A1, NDUFV1, ATP5MC2, UQCR10, SLC25A6, SDHC, NDUFS5, TAF4, NDUFAB1, NDUFB3, CREB5, NDUFC1, VDAC2, ATP5F1A, ATP5PO, NDUFB6, NDUFA4L2, SIN3A, SLC25A31",1.07675598136972,0.471083299722345,FALSE +"H460","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.43064,1.4,0.115,2003,0.398,"CACNA2D1, PRKAA2, TGFB2, ITGB5, ITGAV, ITGA5, DES, LMNA, DAG1, SGCD, ITGA6, ITGA10, ACTG1, SLC8A1, TGFB1, EMD, ITGB1, TPM4",0.939302159646388,0.400116927926312,FALSE +"H460","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.42467,-1.33,0.154,6275,0.43,"MINPP1, INPP5K, INPP4B, PIP4K2A, PIP5K1A, TPI1, PLCB3, PIK3CA, OCRL, PIK3CB, IMPA1, INPPL1, PLCG2, PLCG1, INPP1, INPP5B, PIK3C2B, SYNJ2, ISYNA1",0.812479279163537,0.366531544420413,FALSE +"H460","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.39645,-1.3,0.167,6303,0.438,"PPP1R3D, INPP5K, PRKAG1, CBLB, KRAS, NRAS, RHEB, CRKL, HK2, PRKACB, EXOC7, ACACA, FLOT2, MAP2K2, GYS1, PTPN1, MAP2K1, PRKAG2, PIK3CA, SOS1, PIK3CB, AKT1, RPS6, GSK3B, HK1, IKBKB, RPS6KB2, PHKG2, MAPK1, PIK3R2, RAF1, PTPRF, MAPK3, PKLR, RPS6KB1, ACACB, TSC2, AKT2, PRKCI, FBP1, EIF4EBP1, IRS1, MKNK1",0.777283528852417,0.3585258894959,FALSE +"H460","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.43838,-1.41,0.124,7000,0.484,"PTPN11, SPRY2, IRF9, PIK3CA, SOS1, IFNGR1, PIK3CB, AKT1, PIAS4, PIK3R2, STAT5A, STAT1, SPRY1, AKT2, STAT5B, SPRY4, PTPN6, STAT2, STAT3, PIAS2",0.906578314837765,0.315154638355588,FALSE +"H460","Input","KEGG_LEISHMANIA_INFECTION",-0.52159,-1.66,0.0437,7378,0.372,"IFNGR1, TAB2, IRAK4, TRAF6, ITGA4, MAPK1, MAPK14, RELA, C3, MARCKSL1, MAPK3, STAT1, MAPK13, PTPN6, MAPK12",1.35951856302958,0.429457060118102,FALSE +"H460","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.38753,-1.25,0.204,6642,0.443,"ICAM1, CDH5, RAC1, SIPA1, EZR, PTPN11, ROCK1, RHOA, PIK3CA, PTK2, ROCK2, PIK3CB, VCL, PXN, VASP, CDC42, PLCG2, F11R, ITGA4, ARHGAP5, BCAR1, PLCG1, MAPK14, PIK3R2, ARHGAP35, CLDN7, RAC2, VAV2, MAPK13, CLDN3, MAPK12, CLDN18",0.690369832574101,0.35359627377693,FALSE +"H460","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.29146,0.913,0.52,789,0.755,"ECHS1",0.283996656365201,0.122053048370812,FALSE +"H460","Input","KEGG_LONG_TERM_DEPRESSION",0.25071,0.816,0.671,951,0.812,"CACNA1A, ITPR1, PLCB4, PRKCB, RYR1",0.173277479831008,0.0904439707588247,FALSE +"H460","Input","KEGG_LONG_TERM_POTENTIATION",0.22627,0.737,0.81,725,0.83,"ITPR1, CAMK2D, PLCB4, CAMK4, PRKCB",0.0915149811213502,0.0809219076239261,FALSE +"H460","Input","KEGG_LYSINE_DEGRADATION",0.22704,0.741,0.799,1837,0.864,"SETD7, ECHS1, ASH1L, SETMAR, KMT5C, ACAT1, DLST, EHMT2, TMLHE",0.0974532206860086,0.0634862575211067,FALSE +"H460","Input","KEGG_LYSOSOME",0.497,1.59,0.0685,1208,0.274,"GALC, CTSL, CTSC, CTSZ, CTSV, AGA, GLA, GNS, ASAH1, PPT1, ARSA, IDS, LAMP2, IGF2R, LAMP3, HEXB, TCIRG1, CTSK, CTSO, CLTA, PPT2, CLN3, CLTB, GAA, LAMP1, NAGA, HEXA, PSAP, CTSB, CTSE, CTSF, M6PR, SCARB2",1.16430942850757,0.562249437179612,FALSE +"H460","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.34396,-1.11,0.304,5979,0.506,"PPM1A, MAP3K7, HSPA1A, TAOK2, DUSP3, RPS6KA4, CASP3, AKT3, TAB1, CHUK, MAP3K20, SRF, RPS6KA6, ELK4, TAOK3, KRAS, NRAS, MAPT, IL1A, CRKL, MAP3K3, PRKACB, RAC1, MAPK7, MAP2K2, DUSP1, PPM1B, RPS6KA1, MAP2K1, RELB, PAK1, SOS1, AKT1, TAB2, MAPKAPK2, TRAF6, DAXX, IKBKB, MECOM, CDC42, PPP3CA, RASA1, MAP4K3, MAPK1, MAP3K4, PAK2, NLK, MAPK14, FGFR2, RAF1, RELA, MAPK3, RAC2, PPP5C, MAP3K6, HSPB1, PPP3CB, AKT2, ARRB1, MAPK13, MAP2K4, STMN1, MAPK12, NFATC2, MAP3K1, MKNK1",0.517126416391246,0.295849483160201,FALSE +"H460","Input","KEGG_MELANOGENESIS",-0.34364,-1.14,0.269,6174,0.493,"GNAI3, FZD7, CTNNB1, KRAS, NRAS, PRKACB, PLCB3, MAP2K2, MAP2K1, GSK3B, DVL3, TYRP1, TCF7L2, MAPK1, RAF1, MAPK3, DCT, CREB3L1, TYR",0.570247719997592,0.30715308072277,FALSE +"H460","Input","KEGG_MELANOMA",-0.37259,-1.21,0.229,6979,0.434,"MAP2K2, CDK4, MAP2K1, PIK3CA, HGF, PIK3CB, AKT1, CDH1, MAPK1, PIK3R2, RAF1, MAPK3, AKT2",0.640164517660112,0.362510270487489,FALSE +"H460","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.47525,1.58,0.0601,353,0.266,"MGST1, CYP1B1, AKR1C3, GSTM4, AKR1C1, GSTM1, ALDH3A1",1.22112552799726,0.575118363368933,FALSE +"H460","Input","KEGG_MISMATCH_REPAIR",-0.256,-0.808,0.693,5360,0.8,"POLD3, MSH6, MSH2, PMS2, RFC4, RFC2, LIG1, RFC3, RFC1, RFC5",0.159266765388193,0.0969100130080564,FALSE +"H460","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.39873,-1.27,0.179,5735,0.435,"PIK3CD, PRKAA1, STRADA, MTOR, RICTOR, AKT3, RPS6KA6, RHEB, CAB39, RPS6KA1, PIK3CA, PIK3CB, AKT1, RPS6, STK11, RPS6KB2, MAPK1, PIK3R2, MAPK3, RPS6KB1, TSC2, AKT2, EIF4EBP1",0.747146969020107,0.361510743045363,FALSE +"H460","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.37912,-1.22,0.214,6979,0.447,"MAP2K2, PTPN11, NFATC3, MAP2K1, PIK3CA, PAK1, SOS1, IFNGR1, PIK3CB, PPP3CA, NFAT5, PLCG2, MAPK1, PLCG1, SYK, PIK3R2, RAF1, MAPK3, RAC2, VAV2, MICB, PPP3CB, PTPN6, NFATC2",0.669586226650809,0.349692476868064,FALSE +"H460","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.22772,-0.721,0.805,6008,0.842,"ADRA2A, P2RX4, HTR2B, TSPO, GRIN1, NR3C1, P2RY2",0.0942041196321315,0.0746879085003505,FALSE +"H460","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.4285,-1.36,0.143,6750,0.471,"RAC1, ABL1, MAPK7, MAP2K2, PTPN11, MAGED1, YWHAB, RPS6KA1, MAP2K1, RHOA, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, ARHGDIB, GAB1, YWHAZ, IRAK4, MAPKAPK2, TRAF6, IKBKB, CDC42, PLCG2, MAPK1, PLCG1, SORT1, MAPK14, PIK3R2, RAF1, RELA, CSK, MAPK3, PRKCD, AKT2, NGFR, MAPK13, IRS1, MAPK12, MAP3K1",0.844663962534938,0.326979092871104,FALSE +"H460","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.27037,0.888,0.549,1972,0.73,"BST1, NAMPT, NT5C, ENPP1, CD38",0.260427655549908,0.136677139879544,FALSE +"H460","Input","KEGG_NITROGEN_METABOLISM",0.37242,1.2,0.234,1024,0.493,"CPS1, CA12, GLS, GLS2",0.630784142589857,0.30715308072277,FALSE +"H460","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.52591,-1.71,0.0332,7509,0.671,"TAB2, TRAF6, IKBKB, PYCARD, HSP90AA1, MAPK1, MAPK14, RELA, MAPK3, CCL13, HSP90AB1, CASP1, IL18, MAPK13, MAPK12",1.47886191629596,0.173277479831008,FALSE +"H460","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.20529,-0.655,0.906,5365,0.905,"NHEJ1, XRCC6, PRKDC, DCLRE1C",0.0428718023231869,0.0433514207947967,FALSE +"H460","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.3823,-1.24,0.191,6979,0.437,"MAP2K2, CDK4, RXRB, MAP2K1, RXRG, PIK3CA, SOS1, PIK3CB, AKT1, PLCG2, MAPK1, PLCG1, PIK3R2, RAF1, MAPK3, AKT2, TGFA",0.718966632752272,0.359518563029578,FALSE +"H460","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.3435,1.11,0.302,1143,0.595,"NOTCH3, NOTCH1, NOTCH2, ADAM17, NCSTN",0.519993057042849,0.22548303427145,FALSE +"H460","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.17053,0.555,0.97,7264,0.994,"XPA, GTF2H5, CETN2, RAD23B, POLD4, RBX1, XPC, GTF2H1, POLE3, RPA3, ERCC1, GTF2H2, DDB2, MNAT1, POLD2, CCNH, RAD23A, POLE4, RPA2, ERCC4, GTF2H3, RPA1, PCNA, DDB1, POLD1, GTF2H4, ERCC3, POLD3, ERCC2, CUL4B, ERCC5, CDK7, POLE, RFC4, RFC2, LIG1, RFC3, RFC1, CUL4A, ERCC6, RFC5",0.0132282657337552,0.00261361560268669,FALSE +"H460","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.22316,0.737,0.8,157,0.83,"TUSC3, MGAT4B",0.0969100130080564,0.0809219076239261,FALSE +"H460","Input","KEGG_OLFACTORY_TRANSDUCTION",0.33393,1.07,0.318,1601,0.604,"CAMK2D, CNGB1, CALM2",0.497572880015567,0.218963061378868,FALSE +"H460","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.34095,-1.08,0.323,6197,0.52,"MTHFD1, MTHFR, GART, SHMT1, MTHFS, DHFR, ALDH1L1",0.490797477668897,0.283996656365201,FALSE +"H460","Input","KEGG_OOCYTE_MEIOSIS",-0.37866,-1.21,0.211,6624,0.434,"PPP2R1A, PPP2CA, PRKACB, BUB1, PLK1, CUL1, SMC3, YWHAB, RPS6KA1, MAP2K1, PPP2R5C, YWHAZ, CDC23, PPP3CA, MAPK1, PPP2R5B, CDC16, BTRC, PPP2R5A, CDK1, MAPK3, PPP2R5E, PPP3CB, AURKA, PPP2R5D, FBXO5, CDK2, CCNB1, PTTG1, MAPK12",0.675717544702307,0.362510270487489,FALSE +"H460","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.5695,1.83,0.0534,2199,0.212,"AGA, HEXB, HEXA, MAN2B2, MAN2B1, GLB1, GBA, FUCA2",1.27245874297144,0.673664139071249,FALSE +"H460","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.54277,1.74,0.0426,2564,0.183,"ATP5PF, NDUFS6, ATP5PD, UQCRH, ATP5F1D, NDUFA2, TCIRG1, NDUFS8, NDUFA8, NDUFV2, UQCRFS1, PPA2, UQCRB, NDUFS4, ATP5F1B, ATP5ME, NDUFA7, COX5B, COX6B1, COX6A1, NDUFS1, UQCRC1, NDUFA5, NDUFA3, ATP6V1F, NDUFV3, SDHB, COX5A, COX17, CYC1, NDUFS3, NDUFB8, ATP5F1E, ATP5PB, SDHA, NDUFB2, UQCRC2, COX7A2, NDUFA4, COX7C, ATP5MG, NDUFV1, ATP6AP1, ATP5MC2, ATP6V1E1, UQCR10, SDHC, NDUFS5, NDUFAB1, NDUFB3, NDUFC1, ATP5F1A, ATP5PO, ATP6V0C, NDUFB6, NDUFA4L2, ATP6V1G1",1.37059040089728,0.737548910269571,TRUE +"H460","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.46817,-1.49,0.07,8748,0.441,"GCNT3",1.15490195998574,0.355561410532161,FALSE +"H460","Input","KEGG_P53_SIGNALING_PATHWAY",-0.31637,-1.02,0.4,7624,0.552,"RRM2, CHEK1, THBS1, CDK1, APAF1, TSC2, CD82, CDK2, CCNB1",0.397940008672038,0.258060922270801,FALSE +"H460","Input","KEGG_PANCREATIC_CANCER",-0.32008,-1.04,0.374,7011,0.553,"CDK4, MAP2K1, PIK3CA, BRCA2, PIK3CB, AKT1, IKBKB, CDC42, MAPK1, PIK3R2, RAF1, RELA, MAPK3, RAC2, STAT1, AKT2, STAT3, TGFA",0.42712839779952,0.257274868695302,FALSE +"H460","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.41762,-1.33,0.132,7826,0.43,"DPYD, COASY, PANK4",0.87942606879415,0.366531544420413,FALSE +"H460","Input","KEGG_PARKINSONS_DISEASE",0.5456,1.74,0.0357,2579,0.183,"UCHL1, ATP5PF, NDUFS6, ATP5PD, UQCRH, ATP5F1D, NDUFA2, NDUFS8, SNCA, NDUFA8, NDUFV2, UQCRFS1, UQCRB, NDUFS4, ATP5F1B, NDUFA7, COX5B, COX6B1, VDAC1, COX6A1, UBE2G2, HTRA2, NDUFS1, UQCRC1, NDUFA5, NDUFA3, CYCS, NDUFV3, SDHB, COX5A, CYC1, NDUFS3, NDUFB8, ATP5F1E, ATP5PB, SDHA, NDUFB2, UQCRC2, COX7A2, NDUFA4, COX7C, NDUFV1, ATP5MC2, UQCR10, SLC25A6, SDHC, NDUFS5, NDUFAB1, NDUFB3, NDUFC1, VDAC2, ATP5F1A, ATP5PO, NDUFB6, NDUFA4L2, SLC25A31",1.44733178388781,0.737548910269571,TRUE +"H460","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.43898,-1.39,0.132,5720,0.458,"YWHAQ, TUBA3C, FYN, TUBB4B, NCK1, TUBB6, CTNNB1, ARPC1B, ABL1, HCLS1, EZR, ARPC1A, ROCK1, RHOA, ROCK2, TUBA1B, ARPC4, TUBB3, TUBB1, YWHAZ, CDH1, ARPC3, CDC42, TUBB, ARPC2, TUBB2A, WASL, CTTN, TUBA1C",0.87942606879415,0.339134521996131,FALSE +"H460","Input","KEGG_PATHWAYS_IN_CANCER",-0.23294,-0.767,0.768,6941,0.837,"LAMB3, GSTP1, MAP2K2, CDK4, CUL2, RXRB, MAP2K1, CKS1B, RHOA, RXRG, PIK3CA, STK36, BRCA2, HGF, SOS1, PTK2, TFG, PIK3CB, AKT1, GSK3B, PIAS4, ARNT, CDH1, TRAF6, IKBKB, MECOM, CDC42, DVL3, HSP90AA1, PLCG2, TCF7L2, MAPK1, DAPK1, PLCG1, RARA, LAMA3, LAMA4, PIK3R2, FGFR2, RAF1, RELA, STAT5A, MAPK3, TRAF3, RAC2, STAT1, NCOA4, HSP90AB1, AKT2, STAT5B, CDK2, STAT3, PIAS2, TGFA",0.114638779968488,0.07727454200674,FALSE +"H460","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.28819,-0.925,0.512,6725,0.637,"RPE, UGP2, XYLB, CRYL1",0.290730039024169,0.19586056766465,FALSE +"H460","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.52521,-1.72,0.0285,6028,0.77,"RBKS, ALDOC, PFKP, RPE, PRPS2, PGLS, PFKM, RPIA, PGM2, GPI, DERA, PGM1, PFKL, FBP1",1.54515513999149,0.113509274827518,FALSE +"H460","Input","KEGG_PEROXISOME",-0.21418,-0.706,0.855,7303,0.856,"EHHADH, CAT, CRAT, IDH2, PEX6, MVK, FAR1, DAO, FAR2",0.0680338852718274,0.0675262353228468,FALSE +"H460","Input","KEGG_PHENYLALANINE_METABOLISM",0.27242,0.871,0.586,1755,0.749,"ALDH3A1, GOT2, MAOA",0.232102383981909,0.125518182300534,FALSE +"H460","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.34129,-1.1,0.311,6587,0.505,"INPP4B, PIP4K2A, PIP5K1A, CDS2, PLCB3, PIK3CA, OCRL, PIK3CB, IMPA1, INPPL1, PLCG2, PLCG1, INPP1, PIK3R2, DGKA, INPP5B, PIK3C2B, SYNJ2, DGKH",0.507239610973163,0.296708621881339,FALSE +"H460","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.38312,1.24,0.215,2696,0.463,"HMOX1, ALAS1, FECH, HMOX2, HCCS, PPOX, GUSB, UGT2B17, EARS2, FTH1",0.667561540084395,0.334419008982047,FALSE +"H460","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.2417,-0.777,0.733,7109,0.829,"RXRB, DBI, CYP27A1, RXRG, EHHADH, CD36, FABP2, HMGCS2, FABP3",0.134896025358872,0.0814454694497265,FALSE +"H460","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45982,1.48,0.0776,129,0.338,"AKR1D1",1.11013827874181,0.471083299722345,FALSE +"H460","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.46106,-1.47,0.103,6546,0.432,"TAP2, UNG, ADA, DCLRE1C, PTPRC",0.987162775294828,0.364516253185088,FALSE +"H460","Input","KEGG_PRION_DISEASES",0.54598,1.75,0.0458,689,0.209,"NCAM2, NCAM1, LAMC1, C9, HSPA5, NOTCH1",1.33913452199613,0.679853713888946,TRUE +"H460","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.3699,-1.2,0.211,7138,0.44,"RPS6KA1, MAP2K1, PIK3CA, PIK3CB, AKT1, FZR1, CDC23, HSP90AA1, MAPK1, CDC16, MAPK14, PIK3R2, RAF1, CDK1, MAPK3, HSP90AB1, CCNA2, AKT2, CDK2, CCNB1, MAPK13, MAPK12",0.675717544702307,0.356547323513813,FALSE +"H460","Input","KEGG_PROPANOATE_METABOLISM",0.27859,0.893,0.528,1587,0.749,"ACSS3, MCEE, ECHS1, SUCLG1, SUCLG2, ACAT1, PCCB",0.277366077466188,0.125518182300534,FALSE +"H460","Input","KEGG_PROSTATE_CANCER",-0.44992,-1.44,0.1,6950,0.456,"GSTP1, MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, IKBKB, HSP90AA1, TCF7L2, MAPK1, PIK3R2, FGFR2, RAF1, RELA, MAPK3, HSP90AB1, CREB3L1, AKT2, CDK2, TGFA",1,0.341035157335565,FALSE +"H460","Input","KEGG_PROTEASOME",0.15261,0.486,0.992,6839,0.996,"PSMB9, PSMB7, PSMA5, PSMC3, PSMB6, PSMA1, PSMC4, PSMA2, PSMB3, PSMC5, PSMD14, PSMB5, PSMC1, PSMA6, PSMC2, PSMC6, PSMA3, PSMB4, PSMD4, PSMA4, POMP, PSMD7, PSMA7, PSME3, PSMB2, PSMB10, PSMB8, PSMA8, PSMD8, PSMD13, PSMD11, PSMB1, PSMF1, PSMD6, PSMD2, PSMD12, PSMD1, PSME4, SEM1, PSME1, PSMD3",0.00348832784582135,0.00174066157630127,FALSE +"H460","Input","KEGG_PROTEIN_EXPORT",0.23327,0.75,0.776,622,0.863,"HSPA5, SPCS1",0.110138278741812,0.0639892042847904,FALSE +"H460","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.27386,-0.917,0.522,8202,0.643,"MDH1, GLUD2",0.282329496997738,0.191789027075778,FALSE +"H460","Input","KEGG_PURINE_METABOLISM",0.28608,0.924,0.505,1909,0.748,"PAPSS2, PDE3B, PDE4D, PDE3A, POLR3H, NUDT9, POLR3K, POLR2H, POLR3D, GDA, POLR2C, NME4, POLR2L, POLR2D, POLR1E, AK2, NT5C, POLR2E, GUK1, POLR3GL, PRUNE1, POLR3G, POLR3C, ENPP1, POLD4, NME3, POLR2I, PFAS, PNPT1, POLR3F, POLR2F",0.296708621881339,0.126098402135539,FALSE +"H460","Input","KEGG_PYRIMIDINE_METABOLISM",0.29286,0.956,0.456,1909,0.747,"POLR3H, POLR3K, POLR2H, POLR3D, TXNRD2, POLR2C, NME4, POLR2L, UPRT, TXNRD1, POLR2D, POLR1E, DUT, NT5C, POLR2E, TYMP, POLR3GL, POLR3G, POLR3C, POLD4, NME3, POLR2I, PNPT1, POLR3F, POLR2F",0.341035157335565,0.126679398184601,FALSE +"H460","Input","KEGG_PYRUVATE_METABOLISM",-0.26043,-0.859,0.598,6912,0.723,"ACACA, ACYP1, ACSS2, GLO1, ACAT2, MDH1, PKLR, ACACB, PKM",0.223298816011589,0.140861702705469,FALSE +"H460","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.38927,-1.24,0.207,6398,0.437,"KRAS, NRAS, ARPC1B, WASF2, CRKL, FGD3, PIP4K2A, CYFIP1, PIP5K1A, ITGA2, RAC1, SLC9A1, ARHGEF1, EZR, MAP2K2, IQGAP3, ARPC1A, ARHGEF7, PAK3, ROCK1, ITGB6, MAP2K1, RHOA, PIK3CA, PAK1, SOS1, PTK2, ROCK2, PAK4, PIK3CB, RDX, VCL, ARPC4, DIAPH3, MYH10, ARPC3, PXN, CFL1, ARHGEF12, CDC42, SCIN, ITGA4, ARPC2, MAPK1, BCAR1, NCKAP1, MYH14, PAK2, MYLK, PIK3R2, FGFR2, ARHGAP35, RAF1, ITGB3, MYH9, CSK, MAPK3, RAC2, VAV2, GSN, SSH3, DIAPH1, BAIAP2, WASL, CYFIP2",0.684029654543082,0.359518563029578,FALSE +"H460","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.29623,-0.964,0.468,5747,0.599,"PRKAA1, GABARAPL2, PIK3C3, ATG12, PIK3R4, ATG7, ATG3, ATG4B",0.329754146925876,0.222573177610689,FALSE +"H460","Input","KEGG_RENAL_CELL_CARCINOMA",-0.41953,-1.34,0.146,6398,0.469,"KRAS, NRAS, CRKL, RAC1, MAP2K2, PTPN11, PAK3, CUL2, MAP2K1, PIK3CA, PAK1, HGF, SOS1, PAK4, PIK3CB, AKT1, ARNT, GAB1, CDC42, MAPK1, PAK2, PIK3R2, RAF1, MAPK3, AKT2, TGFA",0.835647144215563,0.328827157284917,FALSE +"H460","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.23037,-0.759,0.782,8024,0.833,"MME",0.106793246940152,0.0793549985932124,FALSE +"H460","Input","KEGG_RETINOL_METABOLISM",-0.41015,-1.33,0.139,6676,0.43,"DHRS3, RDH11, ADH5, DGAT1, RDH10, ADH1C, DHRS9",0.856985199745905,0.366531544420413,FALSE +"H460","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.46756,-1.52,0.0772,8118,0.419,"ACP5, TYR",1.11238269966426,0.377785977033705,FALSE +"H460","Input","KEGG_RIBOSOME",-0.54356,-1.74,0.0351,6007,0.887,"RPL36, RPL27, RPL31, RPS26, RPL18, RPL11, RPS7, RPL3, RPS3, RPS13, RPS5, RPS9, RPL23, RPL10, RPL15, RPL26, RPL37A, RPL32, RPL18A, RPL10A, RPL7, RPS18, RPL14, RPL21, RPS15A, RPL35, RPS4X, RPS19, RPL8, RPS6, RPS2, RPL37, RPL9, RPL30, RPS24, RPS16, RPS25, RPL13A, RPL17, RPL28, RPL29, RPL19, RPL23A, RPL34, RPL27A, RPL24, RSL24D1, RPL22, RPL7A, FAU, RPS11, RPL36A, RPL36AL, RPS27L, UBA52, RPS23, RPS10, RPL38",1.45469288353418,0.0520763801682736,FALSE +"H460","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.49258,-1.59,0.0621,7571,0.391,"TRAF6, IKBKB, RIPK1, MAPK14, RELA, TRAF3, IFIH1, MAPK13, ISG15, MAPK12, MAP3K1, CYLD",1.20690839982342,0.407823242604133,FALSE +"H460","Input","KEGG_RNA_DEGRADATION",0.35517,1.16,0.268,2342,0.526,"HSPA9, HSPD1, EXOSC8, LSM4, DCP2, TENT4A, EXOSC1, LSM2, EXOSC4, EXOSC10, LSM8, EXOSC6, MPHOSPH6, DCPS, LSM3, EXOSC5, DCP1A, PNPT1, PARN, EXOSC7, WDR61, EXOSC9, CNOT2, LSM6",0.571865205971211,0.279014255846261,FALSE +"H460","Input","KEGG_RNA_POLYMERASE",0.6689,2.11,0.00832,2035,0.123,"POLR3H, POLR3K, POLR2H, POLR3D, POLR2C, POLR2L, POLR2D, POLR1E, POLR2E, POLR3GL, POLR3G, POLR3C, POLR2I, POLR3F, POLR2F, POLR2G",2.07987667370928,0.910094888560602,TRUE +"H460","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.33732,1.09,0.312,116,0.617,"PAPSS2, GGT1",0.505845405981557,0.209714835966758,FALSE +"H460","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.2783,0.896,0.553,398,0.758,"FN1, LAMB1, PIK3R3, LAMA1, LAMC1, LAMA5, ITGAV, LAMB2",0.257274868695302,0.120330794367946,FALSE +"H460","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.2615,-0.84,0.643,8342,0.75,"VAMP8, YKT6, VAMP3",0.191789027075778,0.1249387366083,FALSE +"H460","Input","KEGG_SPHINGOLIPID_METABOLISM",0.60432,1.92,0.014,383,0.194,"GALC, PLPP3, GLA, ASAH1, ARSA",1.85387196432176,0.712198270069774,TRUE +"H460","Input","KEGG_SPLICEOSOME",0.29516,0.968,0.447,2731,0.739,"PPIE, SNRPB2, SF3B4, LSM4, SRSF1, SNU13, LSM2, SNRPD3, SNRPF, HNRNPU, SRSF8, PHF5A, TRA2A, SNRPG, SF3B5, SRSF6, SRSF7, LSM8, SRSF5, PRPF18, SRSF9, PPIH, TXNL4A, RBM8A, SRSF3, LSM3, HNRNPA3, TCERG1, SRSF2, SRSF10, ISY1, NCBP2, TRA2B, RBM25, SF3A3, HNRNPK, RBMX, SNRPA, U2SURP, DDX5, SF3A1, SRSF4, LSM6, BCAS2, PRPF40A, ALYREF, SNRPB, PRPF4, RBM17, DHX8, CHERP, SNRNP70, SNRNP40, THOC3, DDX46",0.349692476868064,0.131355561605174,FALSE +"H460","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.39267,-1.26,0.193,7080,0.44,"GYS1, PGM2, UGP2, MGAM, GPI, HK1, AGL, PGM2L1, PGM1",0.714442690992226,0.356547323513813,FALSE +"H460","Input","KEGG_STEROID_BIOSYNTHESIS",-0.62399,-1.92,0.0214,6129,0.82,"CEL, LIPA, CYP51A1, LSS, NSDHL, SQLE, MSMO1, HSD17B7, SOAT2, FDFT1, DHCR24, TM7SF2, DHCR7",1.66958622665081,0.0861861476162833,FALSE +"H460","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.69483,2.23,0.00204,285,0.0837,"CYP21A2, AKR1D1, CYP1B1, AKR1C3, AKR1C1",2.6903698325741,1.07727454200674,TRUE +"H460","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.3127,0.996,0.423,1265,0.699,"C9, SNRPD3, C7",0.373659632624958,0.155522824254319,FALSE +"H460","Input","KEGG_TASTE_TRANSDUCTION",0.53334,1.7,0.0334,2207,0.196,"CACNA1A, GNB1, GNB3, GNAS",1.47625353318844,0.707743928643524,TRUE +"H460","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.66274,-2.11,0.00977,7922,0.672,"ACAT2, MVD, HMGCS2, MVK, FDPS, HMGCS1",2.01010543628123,0.172630726946175,FALSE +"H460","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28637,0.904,0.53,536,0.757,"FST, TGFB2, TGFBR1, E2F5, THBS3, SMAD2",0.275724130399211,0.120904120499927,FALSE +"H460","Input","KEGG_THYROID_CANCER",-0.50513,-1.65,0.0461,6376,0.36,"CTNNB1, KRAS, NRAS, MAP2K2, RXRB, MAP2K1, RXRG, TFG, CDH1, TCF7L2, MAPK1, MAPK3, NCOA4",1.33629907461035,0.443697499232713,FALSE +"H460","Input","KEGG_TIGHT_JUNCTION",-0.27612,-0.884,0.588,5842,0.695,"TJP3, PPP2R2B, CSNK2A1, CSNK2A2, PPP2R2A, MYL12A, PPP2CB, GNAI3, AKT3, PARD6G, MAP3K20, LLGL2, CTNNB1, KRAS, NRAS, RAB13, PPP2R1A, PPP2CA, HCLS1, CDK4, EPB41, RHOA, TJAP1, AKT1, MYH10, PRKCQ, CDC42, F11R, MYH14, MYH7B, CLDN7, MYH3, MYH9, CGN, PRKCD, AKT2, PRKCI, CTTN, MYH11, EPB41L1, CLDN3, CRB3, CLDN18",0.230622673923862,0.158015195409886,FALSE +"H460","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.36332,-1.17,0.23,6925,0.466,"TBK1, MAP2K2, MAP2K1, PIK3CA, IRF3, PIK3CB, AKT1, TAB2, IRAK4, TRAF6, IKBKB, RIPK1, MAPK1, MAPK14, PIK3R2, RELA, MAPK3, TRAF3, STAT1, AKT2, MAPK13, MAP2K4, MAPK12",0.638272163982407,0.33161408331,FALSE +"H460","Input","KEGG_TRYPTOPHAN_METABOLISM",0.25244,0.812,0.697,789,0.792,"CYP1B1, KYNU, ECHS1",0.156767221901991,0.101274818410506,FALSE +"H460","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.40881,-1.3,0.154,7221,0.438,"PIK3CA, PIK3CB, HK1, IKBKB, MAPK1, PIK3R2, MAPK3, PKLR, PRKCD, PKM, IRS1",0.812479279163537,0.3585258894959,FALSE +"H460","Input","KEGG_TYROSINE_METABOLISM",-0.52107,-1.68,0.0581,6759,0.448,"COMT, MIF, GOT1, ADH5, TYRP1, ADH1C, TRMT11, METTL2B, LCMT1, ALDH1A3, DCT, TYR",1.23582386760967,0.348721986001856,FALSE +"H460","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.52938,-1.7,0.03,6979,0.463,"MAP2K2, CDK4, PAK3, NFATC3, MAP2K1, RHOA, PIK3CA, PAK1, SOS1, PAK4, PIK3CB, AKT1, GSK3B, PRKCQ, IKBKB, CDC42, PPP3CA, NFAT5, MAPK1, PLCG1, PAK2, MAPK14, PIK3R2, RAF1, RELA, MAPK3, VAV2, PPP3CB, AKT2, PTPRC, MAPK13, PTPN6, MAPK12, NFATC2",1.52287874528034,0.334419008982047,FALSE +"H460","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.30709,-1,0.401,5542,0.57,"FBXO4, CUL4B, HERC2, HUWE1, FBXO2, UBE2D4, HERC4, SMURF1, CBL, UBE2N, CDC34, UBE2NL, UBE2K, UBA2, ANAPC4, UBA1, UBE2Q1, TRIM32, CBLB, UBE2L3, UBE4B, UBE2D2, NEDD4L, CUL3, CUL5, CUL1, DET1, UBE2O, CUL2, ITCH, CUL4A, UBE2E1, UBA6, SYVN1, PIAS4, FZR1, TRAF6, UBE2E2, WWP1, CDC23, TRIM37, CDC16, BTRC, KEAP1, SMURF2, UBE2C, UBE2L6, MAP3K1, PIAS2",0.396855627379818,0.244125144327509,FALSE +"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.31571,1.01,0.384,1137,0.687,"PDHB, PDHA1",0.415668775632469,0.16304326294045,FALSE +"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.38241,1.23,0.202,1863,0.462,"ACAA2, HSD17B10, MCEE, HIBADH, ACADSB, ECHS1, OXCT1, ACADS, IVD, ACAT1, BCKDHB, PCCB, AUH, BCKDHA, DLD",0.694648630553376,0.335358024443874,FALSE +"H460","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.28505,-0.928,0.492,6712,0.639,"PRKACB, PLCB3, ARHGEF1, MAP2K2, ROCK1, MAP2K1, RHOA, ROCK2, PRKCQ, ARHGEF12, MAPK1, MYLK, RAF1, MAPK3, PRKCD, MYH11",0.30803489723264,0.1944991418416,FALSE +"H460","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.42696,-1.35,0.121,5663,0.469,"ARHGDIA, RAB5B, NSF, DCTN1, DYNC1LI2, RAB5A, DYNLL1, PRKACB, DYNC1LI1, RAB11A, VAMP2, DYNLL2, ARHGDIB, DYNC1H1, RAB5C, DYNC2H1, CREB3L1",0.91721462968355,0.328827157284917,FALSE +"H460","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.5541,-1.79,0.0238,6979,0.96,"MAP2K2, NFATC3, MAP2K1, PIK3CA, PTK2, PIK3CB, AKT1, MAPKAPK2, PXN, CDC42, PPP3CA, NFAT5, PLCG2, MAPK1, PLCG1, MAPK14, PIK3R2, RAF1, MAPK3, RAC2, HSPB1, PPP3CB, AKT2, MAPK13, MAPK12, NFATC2",1.62342304294349,0.0177287669604316,FALSE +"H460","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.22788,0.739,0.789,2778,0.853,"TJP1, TCIRG1, PRKCB, ATP6V1F, SLC12A2, PDIA4, ACTG1, ATP6AP1, GNAS, ATP6V1E1, ACTB, ATP6V0C, ATP6V1G1, ATP6V1B2, ADCY9",0.10292299679058,0.069050968832477,FALSE +"H460","Input","KEGG_VIRAL_MYOCARDITIS",-0.3596,-1.18,0.246,6642,0.461,"ICAM1, RAC1, ABL1, EIF4G2, MYH10, EIF4G1, MYH14, MYH7B, MYH3, MYH9, RAC2, MYH11, ABL2",0.609064892896621,0.336299074610352,FALSE +"H460","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.26673,-0.87,0.615,5901,0.71,"CSNK2A1, CSNK2A2, MAP3K7, SMAD3, PPP2CB, CACYBP, FZD7, CSNK1E, CTNNB1, PPP2R1A, PPP2CA, PRKACB, RAC1, PLCB3, DAAM1, CUL1, ROCK1, NFATC3, RHOA, ROCK2, PPP2R5C, GSK3B, DVL3, PPP3CA, NFAT5, TCF7L2, PPP2R5B, BTRC, CSNK1A1, NLK, PPP2R5A, PPP2R5E, RAC2, PPP3CB, PPP2R5D, NFATC2",0.211124884224583,0.148741651280925,FALSE +"H520","Input","KEGG_ABC_TRANSPORTERS",-0.288,-0.879,0.554,6792,0.679,"ABCA2, ABCD1, ABCC3, ABCA12, ABCG2, ABCA1, ABCB8",0.25649023527157,0.168130225719498,FALSE +"H520","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.3015,-0.919,0.53,5328,0.652,"ARAF, RELA, AKT3, STAT3, GRB2, BRAF, STAT5A, PIK3CB, NFKB1, AKT1, PIK3R1, PML, CHUK, MAPK3, MAPK1, PIK3R3, IKBKG, SOS1, CCND1, IKBKB",0.275724130399211,0.18575240426808,FALSE +"H520","Input","KEGG_ADHERENS_JUNCTION",-0.43395,-1.29,0.165,6625,0.433,"WAS, MAPK3, NECTIN4, RHOA, MAPK1, ACTN2, PARD3, MET, ERBB2, ACTN1, CDH1, MAP3K7, EGFR, NECTIN2, RAC3, VCL, BAIAP2, PTPRJ, TGFBR2, IQGAP1, IGF1R, RAC2",0.782516055786094,0.363512103646635,FALSE +"H520","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.38133,-1.13,0.273,5343,0.458,"PRKAB1, RELA, AKT3, PRKAB2, STAT3, NFKB1, NFKBIB, AKT1, TRAF2, CHUK, TRADD, IRS2, IKBKG, ACSL4, IRS1, IKBKB, PRKCQ, RXRG",0.563837352959244,0.339134521996131,FALSE +"H520","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.37669,1.18,0.216,282,0.438,"GLUD2, ASS1, GPT2, GOT2",0.665546248849069,0.3585258894959,FALSE +"H520","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.42171,-1.26,0.162,6303,0.414,"PIK3R1, PRKCA, MAPK3, MAPK1, IRS2, PIK3R3, SLC9A3R2, NEDD4L, PRKCB, IRS1, PRKCG",0.790484985457369,0.382999658879101,FALSE +"H520","Input","KEGG_ALZHEIMERS_DISEASE",0.32205,1.01,0.379,2586,0.57,"MME, ITPR1, SDHD, ATP5MC2, NDUFA6, ATP5F1C, GRIN1, NDUFS7, ERN1, UQCRH, BAD, CASP7, ATP5PO, PSEN2, ATP5PB, ADAM10, ATP5F1B, ATP5F1E, ATP5F1A, NDUFA9, CYC1, NDUFB3, NDUFA7, NDUFA4, NDUFB7, HSD17B10, SDHC, NDUFB4, NDUFS8, NDUFS6, GSK3B, NDUFS5, NDUFC2, UQCRC2, UQCRFS1, ATP5PD, NDUFA10, CALML3, NDUFB8, NDUFV1, SDHB, NDUFS4, NDUFS3, COX4I1, ATF6, NDUFAB1, NDUFS1, PSEN1, ATP2A2, COX7C, NDUFS2, NDUFB2, NDUFV2, COX7A2L, NDUFB6, UQCRB, NDUFA3, UQCRQ, SNCA, NCSTN",0.421360790031928,0.244125144327509,FALSE +"H520","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.61161,1.91,0.025,1050,0.282,"WARS2, RARS2, EARS2, CARS2, LARS2, NARS2, MTFMT",1.60205999132796,0.549750891680639,FALSE +"H520","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.41469,-1.23,0.186,6115,0.43,"UGP2, AMDHD2, HEXB, GNPNAT1, GFPT2, CMAS, GMPPB, GMPPA, NAGK, GFPT1, GALK1, UAP1, UGDH, NPL, PGM1, GALE",0.730487055782084,0.366531544420413,FALSE +"H520","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.24265,0.787,0.718,982,0.809,"MAP2K6, SOD1, NEFL, GRIN1, DERL1, BAD, BCL2L1",0.1438755557577,0.0920514783877277,FALSE +"H520","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.52673,-1.58,0.0611,6404,0.442,"TAP2, HSP90AB1, TAPBP, CALR, HSPA6, HSP90AA1, PSME3, CTSL, CD74, LGMN, B2M, CTSB, HSPA2, HSPA1L, CTSS",1.21395878975745,0.354577730650908,FALSE +"H520","Input","KEGG_APOPTOSIS",-0.45471,-1.35,0.12,5725,0.4,"DFFB, PIK3CB, PRKAR2B, PPP3CB, NFKB1, PPP3CA, IRAK4, RIPK1, AKT1, PIK3R1, PRKACA, DFFA, TRAF2, CASP8, FADD, MYD88, CHUK, CASP6, TRADD, IL1RAP, BIRC2, PIK3R3, FAS, IKBKG, BID, ENDOD1, APAF1, CAPN1, TP53, CAPN2, PPP3R1, IKBKB, TNFRSF10D",0.920818753952375,0.397940008672038,FALSE +"H520","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.52063,-1.55,0.0797,7424,0.356,"PLA2G4A, CBR3, ALOX5, GGT1, EPHX2, PTGS2, PTGES",1.09854167860389,0.448550002027125,FALSE +"H520","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.43402,1.37,0.135,539,0.297,"MAOB, ALDH2, GLUD2, ASS1, GATM, MAOA, GOT2, ALDH3A2, PYCR1, SMS, CKB",0.869666231504994,0.527243550682788,FALSE +"H520","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.41071,-1.21,0.233,6698,0.427,"ITGB3, ACTN2, ACTN1, ITGB5, ITGA2B, DES, ITGB1, ITGAV, ITGA1, LMNA, GJA1, ITGA3, ITGA5, ITGB6",0.632644078973981,0.369572124974976,FALSE +"H520","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.60321,1.86,0.0442,1756,0.191,"ALDH2, ALDH3A2, ALDH7A1, ALDH9A1, ALDH1B1",1.35457773065091,0.718966632752272,TRUE +"H520","Input","KEGG_AXON_GUIDANCE",-0.47552,-1.43,0.114,6559,0.373,"ROCK2, ABLIM1, MAPK3, ABL1, SRGAP1, RHOA, MAPK1, LIMK1, MET, ROCK1, SEMA4B, EPHA6, NRP1, ABLIM3, SRGAP2, SRGAP3, SLIT2, PLXNB2, EFNB2, CFL2, ITGB1, RAC3, EFNA5, L1CAM, EPHA2, PPP3R1, EFNB1, EPHB2, EFNA1, RAC2, NTN4, SEMA3C",0.943095148663527,0.428291168191312,FALSE +"H520","Input","KEGG_BASAL_CELL_CARCINOMA",0.48127,1.52,0.0965,1560,0.275,"FZD1, CTNNB1, TCF7L1, TCF7L2, GSK3B",1.01547268665621,0.560667306169737,FALSE +"H520","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.27489,0.851,0.633,6007,0.717,"TBPL1, GTF2H3, GTF2H4, GTF2H2, TAF9B, TAF2, TAF6L, GTF2H1, TAF12, GTF2A2, GTF2F1, GTF2I, TAF1, TAF5L, GTF2B, GTF2IRD1, TAF9, TBP, GTF2F2, TAF4, TAF7, TAF6, GTF2E2, TAF5, GTF2A1, TAF10, GTF2E1",0.198596289982645,0.1444808443322,FALSE +"H520","Input","KEGG_BASE_EXCISION_REPAIR",-0.29101,-0.866,0.618,6072,0.688,"HMGB1, XRCC1, POLD1, POLD4, POLE3, POLE2, LIG1, POLE, PCNA, PARP4",0.209011524911184,0.162411561764489,FALSE +"H520","Input","KEGG_BETA_ALANINE_METABOLISM",0.48146,1.49,0.101,2076,0.249,"ALDH2, HIBCH, ALDH3A2, MLYCD, SMS, ALDH7A1, ALDH9A1, ALDH1B1, HADHA, ECHS1",0.995678626217357,0.603800652904264,FALSE +"H520","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.40583,1.27,0.169,651,0.363,"FADS2, PECR, HSD17B12, HACD2, FADS1",0.772113295386326,0.440093374963888,FALSE +"H520","Input","KEGG_BLADDER_CANCER",-0.58201,-1.72,0.0397,6638,0.519,"TYMP, MAPK3, MAPK1, ERBB2, DAPK1, CDK4, CDH1, CCND1, EGFR, TP53, DAPK3, RPS6KA5, CDKN2A",1.40120949323689,0.284832642151542,FALSE +"H520","Input","KEGG_BUTANOATE_METABOLISM",0.29553,0.93,0.457,2076,0.642,"ALDH2, ALDH3A2, BDH1, ALDH5A1, ALDH7A1, ALDH9A1, ALDH1B1, OXCT1, HADH, HADHA, PDHA1, L2HGDH, ECHS1",0.34008379993015,0.192464971931147,FALSE +"H520","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.45009,-1.34,0.13,5683,0.404,"GRB2, PTPN6, PIK3CB, PPP3CB, NFKB1, PPP3CA, NFKBIB, AKT1, PIK3R1, NFATC2, BCL10, CHUK, MAPK3, MAPK1, CD22, PIK3R3, IKBKG, SOS1, PRKCB, VAV2, RAC3, PPP3R1, PLCG2, IKBKB, PIK3AP1, CARD11, RAC2",0.886056647693163,0.393618634889395,FALSE +"H520","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.32157,-0.96,0.481,6959,0.601,"ERBB2, PLCB3, ATP2A3, ATP2B2, ATP2B4, PLCD3, EGFR, PRKCB, ERBB4, CACNA1A, PPP3R1, PLCG2, TNNC1, ITPR3, ITPKA, ADCY9, PRKCG, ERBB3",0.317854923626168,0.22112552799726,FALSE +"H520","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.2214,-0.672,0.891,7023,0.902,"TPM1, TPM2, TPM3, TNNC1, TPM4, MYL3",0.0501222959631252,0.0447934624580583,FALSE +"H520","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.37417,-1.13,0.283,6875,0.458,"CD40, CD22, CDH15, CDH3, CLDN11, ICAM2, CDH1, CD58, ITGB1, NECTIN2, L1CAM, ITGAV, CDH5, CLDN4, ICAM1, ITGB2, CD274, SDC4, CLDN6, CD99",0.54821356447571,0.339134521996131,FALSE +"H520","Input","KEGG_CELL_CYCLE",-0.28827,-0.857,0.622,6390,0.697,"MCM4, TTK, MCM7, MCM3, YWHAZ, ABL1, PLK1, CHEK2, CDC45, MCM6, CCNA2, YWHAE, YWHAQ, CDK4, YWHAG, FZR1, YWHAH, YWHAB, PCNA, CCND1, TP53, CCNB1, TGFB1, CDKN2A",0.206209615309181,0.156767221901991,FALSE +"H520","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.34986,-1.07,0.32,5640,0.505,"STAT3, PLCB4, GRB2, BRAF, GNB2, PREX1, PIK3CB, CRK, CCL13, NFKB1, NFKBIB, AKT1, PIK3R1, PRKACA, GRK2, STAT2, DOCK2, WASL, BCAR1, ROCK2, WAS, CHUK, MAPK3, GNG4, RHOA, MAPK1, PARD3, SHC1, ROCK1, PLCB3, ARRB2, PIK3R3, IKBKG, SOS1, STAT1, PXN, CXCL5, CRKL, PRKCB, VAV2, PRKCD, IKBKB, ADCY9, GNG12, ARRB1, RAC2",0.494850021680094,0.296708621881339,FALSE +"H520","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.3625,-1.08,0.339,5683,0.496,"GRB2, BRAF, STAT5A, CTBP2, PIK3CB, CRK, NFKB1, AKT1, PIK3R1, BCR, CHUK, MAPK3, ABL1, MAPK1, SHC1, PIK3R3, IKBKG, SOS1, CDK4, CCND1, CRKL, TP53, TGFB1, TGFBR2, IKBKB, CDKN2A",0.469800301796918,0.304518323509803,FALSE +"H520","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29783,0.938,0.495,2927,0.642,"SDHD, SUCLA2, PCK2, SDHC, PDHA1, CS, SDHB, DLAT, IDH3B, SUCLG1, IDH3G, PDHB, SDHA, IDH1, IDH3A",0.305394801066431,0.192464971931147,FALSE +"H520","Input","KEGG_COLORECTAL_CANCER",-0.29811,-0.912,0.502,6266,0.65,"AKT1, PIK3R1, MSH2, MAPK3, MLH1, RHOA, MAPK1, BIRC5, PIK3R3, CCND1, TP53, RAC3, TGFB1, TGFBR2, RAC2",0.299296282854981,0.187086643357144,FALSE +"H520","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.44316,-1.32,0.159,7300,0.412,"PLG, MBL2, F8, CD59, C3, CD55, A2M, PLAU, CFB, SERPINE1, CFI, SERPINA1, TFPI",0.798602875679548,0.385102783966865,FALSE +"H520","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.22395,0.701,0.86,1687,0.896,"GOT2, DNMT3B, SMS, DNMT3A, CBS, MAT1A, APIP, MAT2A",0.0655015487564323,0.0476919903378748,FALSE +"H520","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.37407,-1.11,0.31,6842,0.479,"MET, CD40, IL1RAP, TNFRSF21, FAS, IFNGR1, HGF, ACVR1, CXCL5, EGFR, IL6ST, TGFB1, TGFBR2, IL6, EPO, OSMR, LTBR, IL18, TNFRSF10D",0.508638306165727,0.319664486585437,FALSE +"H520","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.53277,-1.59,0.0623,5897,0.455,"TBK1, NFKB1, NFKBIB, TREX1, RIPK1, CHUK, IKBKG, DDX58, IRF3, IKBKB, IL6, ZBP1, IL18",1.20551195334083,0.341988603342888,FALSE +"H520","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.53114,-1.61,0.0585,7023,0.488,"TPM1, TPM2, ITGB5, ITGA2B, DES, ITGB1, TPM3, TGFB1, ITGAV, ITGA1, LMNA, TNNC1, TPM4, MYL3, ADCY9, ITGA3, ITGA5, ITGB6",1.23284413391782,0.311580177997289,FALSE +"H520","Input","KEGG_DNA_REPLICATION",-0.53333,-1.59,0.0598,4986,0.455,"POLA1, RFC5, RNASEH1, POLD2, RFC2, RFC4, POLD3, MCM5, POLA2, RPA3, PRIM1, POLD1, MCM4, MCM7, MCM3, PRIM2, POLD4, POLE3, RNASEH2A, RNASEH2C, POLE2, MCM6, LIG1, POLE, PCNA",1.22329881601159,0.341988603342888,FALSE +"H520","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.6349,-1.92,0.0167,6679,0.351,"MAPK3, MAPK1, NOTCH2, SOS1, EGFR, NOTCH3, ETV6, ETS1, ETS2",1.77728352885242,0.454692883534176,FALSE +"H520","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.57053,1.84,0.0247,204,0.183,"MAOB, ALDH3A1, GSTA4, GSTM2, GSTA5, MAOA",1.60730304674033,0.737548910269571,TRUE +"H520","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.48686,-1.49,0.0766,7911,0.373,"DPYD, UPP1, TPMT, CDA",1.1157712303674,0.428291168191312,FALSE +"H520","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.4673,-1.38,0.131,6996,0.381,"HMMR, ITGB5, COL4A1, ITGA2B, ITGB1, LAMA3, LAMA4, COL6A1, ITGAV, ITGA1, LAMB3, TNC, LAMB1, COL5A2, ITGA3, SDC4, ITGA5, ITGB6",0.882728704344236,0.419075024324381,FALSE +"H520","Input","KEGG_ENDOCYTOSIS",-0.45783,-1.35,0.144,6062,0.4,"RUFY1, LDLR, STAM2, PLD2, SNF8, SMURF2, VPS36, GIT1, CHMP2A, CLTB, VPS37A, GRK2, PRKCI, SH3GLB1, CHMP4C, EHD3, RAB22A, ITCH, HGS, CHMP5, EPN3, HSPA6, PDCD6IP, ARFGAP1, ARFGAP3, RNF41, RAB11FIP4, STAM, PARD3, MET, SH3GLB2, CHMP4A, CHMP4B, ARRB2, RABEP1, DNAJC6, ARF6, EGFR, NEDD4L, ERBB4, EPS15, EPN1, DAB2, CLTA, EHD2, SH3KBP1, EHD1, PARD6B, RAB31, HSPA2, PARD6G, RAB11FIP5, ARRB1, IGF1R, ERBB3, HSPA1L",0.84163750790475,0.397940008672038,FALSE +"H520","Input","KEGG_ENDOMETRIAL_CANCER",-0.34435,-1.01,0.391,5533,0.552,"AKT3, CTNNA1, GRB2, BRAF, PIK3CB, AKT1, PIK3R1, MAPK3, MLH1, MAPK1, ERBB2, ILK, PIK3R3, SOS1, CDH1, CCND1, EGFR, TP53",0.407823242604133,0.258060922270801,FALSE +"H520","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.18133,0.566,0.96,1025,0.989,"PTPRZ1, JAM3, F11R, ATP6V0A1, ADAM10, ATP6V0A2",0.0177287669604316,0.0048037084028206,FALSE +"H520","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.40815,-1.22,0.205,5277,0.421,"NCK2, ARAF, HBEGF, AKT3, PAK2, GRB2, BRAF, STAT5A, PIK3CB, CRK, PLCG1, ABL2, CAMK2D, AREG, AKT1, PIK3R1, PRKCA, MAPK3, ABL1, MAPK1, SHC1, ERBB2, PIK3R3, SOS1, EGFR, CRKL, PRKCB, ERBB4, PLCG2, PRKCG, ERBB3",0.688246138944246,0.375717904164332,FALSE +"H520","Input","KEGG_ETHER_LIPID_METABOLISM",-0.34683,-1.04,0.365,5362,0.525,"PAFAH1B1, PLD1, PLA2G12A, LPCAT1, PAFAH1B2, PLD2, PAFAH1B3, PLPP3, PLA2G4A",0.437707135543525,0.279840696594043,FALSE +"H520","Input","KEGG_FATTY_ACID_METABOLISM",0.46753,1.5,0.104,2076,0.253,"ACAA2, ALDH2, ECI1, ALDH3A2, ACSL5, ALDH7A1, ALDH9A1, ACOX1, CPT2, ECI2, ALDH1B1, CPT1C, HADH, HADHA, GCDH, CPT1A, ECHS1",0.98296666070122,0.596879478824182,FALSE +"H520","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.31983,-0.954,0.484,6266,0.604,"AKT1, PIK3R1, PRKCA, MAPK3, MAPK1, PIK3R3, SOS1, PLA2G4A, PRKCB, VAV2, RAC3, PLCG2, PRKCD, RAC2",0.315154638355588,0.218963061378868,FALSE +"H520","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.4002,-1.19,0.222,5775,0.448,"PIK3CB, CRK, ARPC3, CFL1, ARPC2, PLCG1, PLD2, AKT1, PIK3R1, PRKCA, DOCK2, WASL, MARCKS, WAS, MAPK3, MAPK1, PLPP3, LIMK1, PIK3R3, ARPC1B, ARPC5, PLA2G4A, CFL2, ARF6, CRKL, PRKCB, GSN, VAV2, SCIN, PLCG2, PRKCD, VASP, PRKCG, RAC2, AMPH",0.653647025549361,0.348721986001856,FALSE +"H520","Input","KEGG_FOCAL_ADHESION",-0.56261,-1.71,0.0475,6499,0.431,"BCAR1, FLT4, ROCK2, COL6A3, TLN1, MAPK3, ITGB3, DOCK1, RHOA, MAPK1, PARVB, ACTN2, MET, SHC1, ERBB2, ACTN1, ROCK1, ILK, BIRC2, PIK3R3, ARHGAP35, ITGB5, COL4A1, HGF, SOS1, CAV1, ITGA2B, PXN, CCND1, ITGB1, PPP1R12A, MYL12A, EGFR, CRKL, PRKCB, LAMA3, LAMA4, CAPN2, VAV2, RAC3, COL6A1, VCL, ITGAV, ITGA1, FLNA, LAMB3, TNC, PARVA, LAMB1, MYL9, COL5A2, FLNC, VASP, PRKCG, ITGA3, IGF1R, ZYX, CAV2, FLNB, ITGA5, RAC2, ITGB6",1.32330639037513,0.365522729839268,FALSE +"H520","Input","KEGG_FOLATE_BIOSYNTHESIS",0.47477,1.51,0.0864,75,0.269,"GGH",1.06348625752111,0.570247719997592,FALSE +"H520","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.35974,-1.09,0.319,5729,0.488,"ALDOC, AKR1B1, PMM1, PHPT1, TPI1, FBP2, MTMR1, PFKL, MTMR6, GMPPB, GMPPA, MTMR7, ALDOA, PFKFB2, PFKP",0.496209316942819,0.311580177997289,FALSE +"H520","Input","KEGG_GALACTOSE_METABOLISM",-0.41829,-1.25,0.185,7354,0.419,"GALK1, B4GALT1, PGM1, GALE, PFKP",0.732828271596986,0.377785977033705,FALSE +"H520","Input","KEGG_GAP_JUNCTION",-0.33642,-1,0.402,6679,0.561,"MAPK3, MAPK1, PLCB3, TUBB1, TUBB3, SOS1, EGFR, PRKCB, TUBB4B, GJA1, ITPR3, ADCY9, PRKCG, TUBA4A",0.39577394691553,0.251037138743839,FALSE +"H520","Input","KEGG_GLIOMA",-0.51035,-1.5,0.0956,5683,0.376,"GRB2, BRAF, PIK3CB, PLCG1, CAMK2D, AKT1, PIK3R1, PRKCA, MAPK3, MAPK1, SHC1, PIK3R3, SOS1, CDK4, CCND1, EGFR, PRKCB, TP53, PLCG2, CDKN2A, PRKCG, IGF1R",1.0195421077239,0.424812155072339,FALSE +"H520","Input","KEGG_GLUTATHIONE_METABOLISM",0.315,1,0.415,725,0.573,"GSTA4, GSTM2, GSTA5, PGD, SMS, GCLC, GSTZ1",0.381951903287907,0.24184537803261,FALSE +"H520","Input","KEGG_GLYCEROLIPID_METABOLISM",0.2907,0.912,0.472,1380,0.66,"ALDH2, AKR1A1, AGPAT4, GK, ALDH3A2, PLPP2, PLPP1, ALDH7A1, ALDH9A1, DGKE",0.326058001365912,0.180456064458131,FALSE +"H520","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.30194,-0.899,0.54,5789,0.658,"PLA2G12A, ETNK1, LPCAT1, CDS2, DGKZ, PLD2, GPAT3, LPGAT1, LYPLA2, GPAT4, MBOAT7, CDS1, PLPP3, AGPAT3, GPD2, DGKH, PCYT2, AGPAT2, PLA2G4A, GPD1L, PEMT, DGKA",0.267606240177031,0.181774106386044,FALSE +"H520","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.59227,1.9,0.0137,384,0.244,"PIPOX, MAOB, GLDC, GATM, MAOA, PHGDH, CHDH",1.86327943284359,0.612610173661271,TRUE +"H520","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.26249,-0.772,0.736,6205,0.796,"TPI1, FBP2, GAPDH, PKLR, ENO1, PFKL, LDHA, DLD, PGAM1, PGAM4, ENO2, ALDOA, ALDH1A3, LDHB, PGM1, ACSS2, PFKP, GALM, ALDH3B1",0.133122185662501,0.0990869322623309,FALSE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.37979,-1.14,0.263,8200,0.47,"CHST12",0.580044251510242,0.327902142064283,FALSE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.59244,1.89,0.022,2580,0.218,"EXT2, B3GAT3, B4GALT7, HS2ST1, XYLT2, EXT1, EXTL3, HS3ST1",1.65757731917779,0.661543506395395,TRUE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.7729,-2.34,0,7363,0.078,"ST3GAL1, B4GAT1, B3GNT2, B4GALT1",Inf,1.10790539730952,TRUE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.18809,-0.564,0.966,5019,0.99,"HGSNAT, GLB1, HPSE, GALNS, GUSB, GNS, HEXB, IDS, SGSH",0.0150228735845067,0.00436480540245009,FALSE +"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.23468,0.726,0.795,2188,0.903,"B4GALNT1, SLC33A1, HEXA",0.0996328713435297,0.0443122496864942,FALSE +"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.64224,-1.95,0.0159,6425,0.377,"NAGA, HEXB, ST3GAL1, B3GALT5",1.79860287567955,0.423658649794207,FALSE +"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.82526,-2.46,0,7401,0.0589,"B3GNT3, B4GAT1, B3GNT2, FUT3, B4GALT1, B3GALT5",Inf,1.2298847052129,TRUE +"H520","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.45217,1.43,0.0918,1925,0.266,"PIGX, PIGM, PIGA, PIGO, PGAP1, PIGQ",1.03715731879876,0.575118363368933,FALSE +"H520","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.36436,1.17,0.24,1923,0.438,"MTHFD2, GRHPR, MTHFD1L, CS",0.619788758288394,0.3585258894959,FALSE +"H520","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.28103,-0.833,0.638,6200,0.716,"PLD2, CAMK2D, PRKACA, PRKCA, MAPK3, MAPK1, PLCB3, SOS1, PLA2G4A, EGFR, PRKCB, MMP14, PRKCD, ITPR3, ADCY9",0.195179321278838,0.145086977692144,FALSE +"H520","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.36966,-1.09,0.319,7659,0.488,"LRP2, CSNK1A1",0.496209316942819,0.311580177997289,FALSE +"H520","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.4953,-1.5,0.0793,7231,0.376,"ITGA2B, CD59, CD55, CD9, ITGA1, ANPEP, IL6, CD33, ITGA3, EPO, ITGA5",1.1007268126824,0.424812155072339,FALSE +"H520","Input","KEGG_HISTIDINE_METABOLISM",0.55534,1.77,0.0338,694,0.213,"MAOB, ALDH3A1, ALDH2, MAOA, ALDH3A2, TRMT11",1.47108329972235,0.671620396561262,TRUE +"H520","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.16828,-0.511,0.997,6290,1,"RPA3, POLD1, BLM, POLD4, TOP3B",0.00130484168834428,0,FALSE +"H520","Input","KEGG_HUNTINGTONS_DISEASE",0.32765,1.03,0.369,2479,0.552,"SLC25A4, ITPR1, SOD1, SDHD, ATP5MC2, NDUFA6, TFAM, ATP5F1C, GRIN1, NDUFS7, UQCRH, VDAC1, ATP5PO, ATP5PB, ATP5F1B, ATP5F1E, VDAC3, ATP5F1A, NDUFA9, CYC1, TBPL1, NDUFB3, CREB1, NDUFA7, NDUFA4, NDUFB7, SLC25A31, SDHC, NDUFB4, NDUFS8, POLR2A, SLC25A5, NDUFS6, NDUFS5, NDUFC2, UQCRC2, SIN3A, UQCRFS1, ATP5PD, NDUFA10, NDUFB8, SLC25A6, POLR2B, NDUFV1, POLR2H, VDAC2, SDHB, NDUFS4, NDUFS3, COX4I1, SOD2, NDUFAB1, NDUFS1, HDAC2, COX7C, NDUFS2, NDUFB2, NDUFV2, COX7A2L, NDUFB6, UQCRB, POLR2K, NDUFA3",0.43297363384094,0.258060922270801,FALSE +"H520","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.56424,-1.71,0.0391,7023,0.431,"TPM1, TPM2, ITGB5, ITGA2B, DES, ITGB1, TPM3, TGFB1, ITGAV, ITGA1, LMNA, TNNC1, TPM4, IL6, MYL3, ACE, ITGA3, ITGA5, ITGB6",1.40782324260413,0.365522729839268,FALSE +"H520","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.42131,-1.28,0.166,6626,0.439,"PIP4K2C, SYNJ2, PLCB3, INPP1, PLCD3, PLCG2, ITPK1, IMPA2, ITPKA, INPP4B, ISYNA1",0.779891911959945,0.357535479757879,FALSE +"H520","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.22647,-0.682,0.857,5533,0.906,"AKT3, PRKAB2, PPP1CA, GRB2, BRAF, PIK3CB, PRKAR2B, CRK, PTPN1, EXOC7, FBP2, AKT1, PIK3R1, PRKACA, PKLR, PRKCI, MAPK3, MAPK1, TSC1, SHC1, IRS2, PIK3R3, FASN, SOS1, RHEB, CRKL, PPP1R3D, PYGB, TRIP10, IRS1, IKBKB",0.0670191780768018,0.0428718023231869,FALSE +"H520","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.74123,-2.2,0.00487,6875,0.13,"CD40, TGFB1, IL6, LTBR",2.31247103878537,0.886056647693163,TRUE +"H520","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.4681,-1.4,0.106,5640,0.388,"STAT3, GRB2, STAT5A, PTPN6, PIK3CB, STAM2, IFNAR1, JAK1, AKT1, PIK3R1, STAT2, OSM, STAM, PIK3R3, IFNGR1, SOS1, STAT1, CCND1, IRF9, IL6ST, IL6, STAT6, EPO, OSMR",0.97469413473523,0.411168274405793,FALSE +"H520","Input","KEGG_LEISHMANIA_INFECTION",-0.49863,-1.5,0.0831,5911,0.376,"NFKB1, NFKBIB, IRAK4, JAK1, TAB1, MYD88, MAPK3, MAPK1, CYBA, IFNGR1, STAT1, TAB2, ITGB1, C3, MAP3K7, PRKCB, TGFB1, PTGS2, ITGB2",1.08039897621589,0.424812155072339,FALSE +"H520","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.54327,-1.63,0.0441,6788,0.492,"RHOA, ACTN2, ACTN1, ROCK1, CYBA, PIK3R3, ARHGAP35, CLDN11, PXN, ITGB1, MYL12A, PRKCB, VAV2, VCL, PLCG2, EZR, MYL9, CDH5, VASP, CLDN4, PRKCG, ICAM1, ITGB2, SIPA1, RAC2, CLDN6, CD99",1.35556141053216,0.30803489723264,FALSE +"H520","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.68026,2.13,0.00822,2450,0.26,"ALDH2, ALDH3A2, ALDH7A1, ALDH9A1, ALDH1B1, HADHA, ECHS1, YOD1",2.08512818245995,0.585026652029182,FALSE +"H520","Input","KEGG_LONG_TERM_DEPRESSION",-0.32741,-0.991,0.43,5660,0.556,"PLCB4, BRAF, PPP2CB, PLA2G12A, PPP2R1A, PRKCA, MAPK3, MAPK1, PLCB3, PLA2G4A, PRKCB, CACNA1A, ITPR3, PRKCG, IGF1R",0.366531544420413,0.254925208417942,FALSE +"H520","Input","KEGG_LONG_TERM_POTENTIATION",-0.34625,-1.05,0.369,5643,0.523,"PPP1CA, PLCB4, BRAF, PPP3CB, PPP3CA, RPS6KA6, RPS6KA2, CAMK2D, PRKACA, PRKCA, MAPK3, MAPK1, PLCB3, PPP1R12A, PRKCB, RPS6KA1, PPP3R1, ITPR3, PRKCG",0.43297363384094,0.281498311132726,FALSE +"H520","Input","KEGG_LYSINE_DEGRADATION",0.4799,1.54,0.0644,2201,0.271,"PIPOX, ALDH2, AASS, ALDH3A2, AADAT, NSD3, NSD2, NSD1, ALDH7A1, ALDH9A1, ALDH1B1, HADH, HADHA, GCDH, ECHS1, SETD1A, DOT1L",1.19111413264019,0.567030709125594,FALSE +"H520","Input","KEGG_LYSOSOME",-0.27317,-0.799,0.708,5930,0.766,"AP3M2, CTSC, GNS, AP3M1, AP1S3, CTSZ, CLTB, NAGA, HEXB, GGA1, AP3B1, IDS, AP1S1, AP1B1, ABCA2, TPP1, FUCA1, M6PR, CTSL, NPC2, GGA3, LGMN, CTSA, PSAPL1, CTSV, SGSH, CLTA, TCIRG1, ATP6V0A4, CTSB, CTSS, CTSH, LAPTM4A",0.149966742310231,0.115771230367396,FALSE +"H520","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.42418,-1.26,0.189,5634,0.414,"PAK2, RASA2, HSPA8, GRB2, BRAF, RPS6KA4, MAP3K5, HSPA1A, PLA2G12A, CRK, DUSP3, PPP3CB, NFKB1, PPP3CA, MAP3K20, RPS6KA6, PPM1B, RPS6KA2, MAPKAPK2, SRF, AKT1, PRKACA, PRKCA, NFATC2, TAB1, TRAF2, HSPA6, CHUK, MAPK3, PPM1A, NF1, MAPK1, ARRB2, FAS, IKBKG, SOS1, PLA2G4A, TAB2, MAP3K7, STMN1, EGFR, CRKL, PRKCB, TP53, CACNA1A, TAOK3, RAC3, RPS6KA1, TGFB1, MOS, PPP3R1, MAP3K11, FLNA, TGFBR2, IKBKB, FLNC, STK4, HSPA2, GNG12, RPS6KA5, HSPB1, PRKCG, ARRB1, RRAS, HSPA1L, FLNB, RAC2",0.723538195826756,0.382999658879101,FALSE +"H520","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.2979,-0.901,0.539,6339,0.662,"PKLR, MNX1, IAPP",0.268411234813261,0.1791420105603,FALSE +"H520","Input","KEGG_MELANOGENESIS",0.22826,0.713,0.819,1560,0.892,"KITLG, FZD1, CTNNB1, TCF7L1, GNAO1, PRKACB, CREB1, TCF7L2, ADCY6, MAP2K1, GSK3B",0.0867160982395816,0.0496351456238769,FALSE +"H520","Input","KEGG_MELANOMA",-0.35006,-1.06,0.336,6679,0.514,"MAPK3, MAPK1, MET, PIK3R3, HGF, CDK4, CDH1, CCND1, EGFR, TP53, CDKN2A, IGF1R",0.473660722610156,0.289036881004724,FALSE +"H520","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.59069,1.86,0.0339,182,0.191,"ALDH3A1, AKR1C2, AKR1C1, AKR1C3, GSTA4, GSTM2, GSTA5, EPHX1",1.46980030179692,0.718966632752272,TRUE +"H520","Input","KEGG_MISMATCH_REPAIR",-0.51797,-1.55,0.0699,5079,0.356,"RFC5, POLD2, RFC2, RFC4, MSH6, POLD3, MSH3, RPA3, POLD1, MSH2, POLD4, MLH1, PMS2, LIG1, PCNA",1.15552282425432,0.448550002027125,FALSE +"H520","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.44162,-1.32,0.149,5533,0.412,"AKT3, BRAF, PIK3CB, RPS6KA6, RPS6KA2, RICTOR, CAB39, AKT1, PIK3R1, MAPK3, MAPK1, TSC1, PIK3R3, RHEB, RPS6KA1",0.826813731587726,0.385102783966865,FALSE +"H520","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.51619,-1.55,0.0695,5683,0.356,"GRB2, BRAF, PTPN6, PIK3CB, PPP3CB, PPP3CA, PLCG1, IFNAR1, PIK3R1, PRKCA, NFATC2, MAPK3, MAPK1, SHC1, PIK3R3, FAS, IFNGR1, BID, SOS1, ICAM2, RAET1L, ULBP2, PRKCB, ZAP70, VAV2, RAC3, PPP3R1, PLCG2, PRKCG, ICAM1, ITGB2, TNFRSF10D, RAC2",1.15801519540989,0.448550002027125,FALSE +"H520","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.34073,-1.02,0.382,6304,0.543,"CHRNE, NR3C1, PARD3, FPR2, TSPO, PLG, HCRTR1",0.417936637088291,0.265200170411153,FALSE +"H520","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.48462,-1.45,0.0792,5683,0.373,"GRB2, BRAF, RPS6KA4, MAP3K5, PIK3CB, CRK, NFKB1, PLCG1, RPS6KA6, NFKBIB, IRAK4, RPS6KA2, MAPKAPK2, ZNF274, NGFR, CAMK2D, AKT1, PIK3R1, YWHAZ, MAPK3, ABL1, RHOA, MAPK1, SHC1, YWHAE, YWHAQ, IRS2, PIK3R3, SOS1, ARHGDIA, YWHAG, YWHAH, YWHAB, CRKL, TP53, RPS6KA1, PLCG2, IRS1, PRKCD, IKBKB, ARHGDIB, RPS6KA5",1.10127481841051,0.428291168191312,FALSE +"H520","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.4936,-1.48,0.0801,7280,0.373,"ENPP1, NT5C2, NNMT, PNP, QPRT, NAMPT, NT5E",1.09636748391576,0.428291168191312,FALSE +"H520","Input","KEGG_NITROGEN_METABOLISM",0.41043,1.27,0.188,106,0.363,"CA8, GLUD2",0.72584215073632,0.440093374963888,FALSE +"H520","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.57708,-1.72,0.0342,5875,0.519,"CCL13, NFKB1, SUGT1, NFKBIB, TAB1, HSP90AB1, CASP8, CHUK, MAPK3, HSP90AA1, MAPK1, BIRC2, IKBKG, TAB2, MAP3K7, TAB3, IKBKB, IL6, IL18, TRIP6",1.46597389394386,0.284832642151542,FALSE +"H520","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.23537,-0.709,0.821,7371,0.876,"XRCC4",0.0856568428805592,0.0574958938319193,FALSE +"H520","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.51999,-1.57,0.0617,6266,0.385,"AKT1, PIK3R1, PRKCA, MAPK3, MAPK1, ERBB2, PIK3R3, SOS1, CDK4, CCND1, EGFR, PRKCB, TP53, PLCG2, STK4, CDKN2A, PRKCG, RXRG",1.20971483596676,0.414539270491499,FALSE +"H520","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.15114,-0.444,1,6322,0.999,"NUMB, DTX3L, NOTCH2, NUMBL, NCOR2, NOTCH3",0,0.000434511774017692,FALSE +"H520","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.24838,-0.745,0.782,5785,0.83,"POLD3, ERCC5, RBX1, RAD23A, RPA3, POLD1, POLD4, POLE3, POLE2, LIG1, POLE, PCNA, RAD23B, DDB2",0.106793246940152,0.0809219076239261,FALSE +"H520","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.5139,1.63,0.042,1249,0.262,"MAN2A1, MAN1A1, ALG9, MGAT1, ALG3, STT3A, MAN1C1, DOLPP1, ST6GAL1, ALG5, MOGS, ALG1, GANAB, RPN2",1.3767507096021,0.581698708680255,FALSE +"H520","Input","KEGG_OLFACTORY_TRANSDUCTION",0.22785,0.723,0.838,1766,0.891,"CNGB1, PRKACB, CALML3",0.0767559813697235,0.0501222959631252,FALSE +"H520","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.44863,1.43,0.107,1173,0.266,"MTHFS, MTHFR, MTHFD2, MTFMT, MTHFD1L",0.97061622231479,0.575118363368933,FALSE +"H520","Input","KEGG_OOCYTE_MEIOSIS",-0.37421,-1.13,0.274,5628,0.458,"CDK2, PPP1CA, PPP2CB, CDC26, PPP3CB, PPP2R5A, PPP2R1A, PPP3CA, RBX1, RPS6KA6, AR, RPS6KA2, CAMK2D, PRKACA, YWHAZ, MAPK3, PLK1, AURKA, MAPK1, YWHAE, YWHAQ, YWHAG, YWHAH, STAG3, YWHAB, CCNB1, RPS6KA1, MOS, PPP3R1, ITPR3, ADCY9, IGF1R",0.562249437179612,0.339134521996131,FALSE +"H520","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.20708,0.667,0.916,317,0.914,"MANBA",0.0381045263321496,0.0390538042661686,FALSE +"H520","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.49024,1.58,0.0727,2838,0.27,"SDHD, ATP5MC2, NDUFA6, ATP5F1C, NDUFS7, UQCRH, ATP6V0A1, ATP5PO, COX11, ATP5PB, ATP5MG, ATP5F1B, ATP5F1E, ATP6V0A2, ATP5F1A, NDUFA9, CYC1, NDUFB3, NDUFA7, ATP5ME, NDUFA4, NDUFB7, SDHC, NDUFB4, NDUFS8, NDUFS6, NDUFS5, NDUFC2, UQCRC2, UQCRFS1, ATP6V1B2, ATP5PD, NDUFA10, NDUFB8, ATP12A, NDUFV1, ATP6V1D, ATP6V1H, SDHB, NDUFS4, NDUFS3, COX4I1, NDUFAB1, NDUFS1, COX7C, NDUFS2, ATP6V0D1, NDUFB2, ATP6AP1, NDUFV2, COX7A2L, NDUFB6, UQCRB, NDUFA3, ATP6V1A, UQCRQ, ATP6V1E1, NDUFB10, SDHA, ATP6V1G1, NDUFB9, NDUFC1, UQCRC1",1.13846558914096,0.568636235841013,FALSE +"H520","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.36792,1.14,0.258,986,0.453,"GCNT1, GALNT10, GALNT6",0.58838029403677,0.343901797987168,FALSE +"H520","Input","KEGG_P53_SIGNALING_PATHWAY",-0.48802,-1.46,0.1,6533,0.373,"CASP8, RCHY1, CHEK2, RRM2, FAS, SERPINB5, BID, CDK4, CCND1, APAF1, TP53, CCNB1, DDB2, CD82, CDKN2A, SERPINE1",1,0.428291168191312,FALSE +"H520","Input","KEGG_PANCREATIC_CANCER",-0.38737,-1.18,0.243,6667,0.447,"CHUK, MAPK3, MAPK1, ERBB2, PIK3R3, IKBKG, CDK4, STAT1, CCND1, EGFR, TP53, RAC3, TGFB1, TGFBR2, IKBKB, CDKN2A, RAC2",0.614393726401688,0.349692476868064,FALSE +"H520","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.39467,-1.18,0.262,6861,0.447,"BCAT2, ENPP1, DPYD",0.581698708680255,0.349692476868064,FALSE +"H520","Input","KEGG_PARKINSONS_DISEASE",0.42956,1.34,0.142,2560,0.314,"SLC25A4, UCHL1, SDHD, ATP5MC2, NDUFA6, ATP5F1C, NDUFS7, UQCRH, VDAC1, ATP5PO, ATP5PB, ATP5F1B, ATP5F1E, VDAC3, ATP5F1A, NDUFA9, CYC1, NDUFB3, NDUFA7, NDUFA4, NDUFB7, SLC25A31, SDHC, NDUFB4, NDUFS8, SLC25A5, NDUFS6, NDUFS5, NDUFC2, UQCRC2, UQCRFS1, ATP5PD, NDUFA10, NDUFB8, SLC25A6, NDUFV1, VDAC2, SDHB, NDUFS4, NDUFS3, COX4I1, NDUFAB1, NDUFS1, COX7C, NDUFS2, NDUFB2, NDUFV2, COX7A2L, NDUFB6, UQCRB, NDUFA3, UQCRQ, SNCA",0.847711655616944,0.503070351926785,FALSE +"H520","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.34035,-1.03,0.38,5780,0.534,"TUBB, ARPC3, TUBA1C, ARPC2, OCLN, HCLS1, ACTB, PRKCA, WASL, YWHAZ, ROCK2, WAS, ABL1, RHOA, CTTN, ROCK1, YWHAQ, TUBB1, TUBB3, ARPC1B, ARPC5, CDH1, ITGB1, TUBB4B, EZR, TUBA4A",0.42021640338319,0.272458742971444,FALSE +"H520","Input","KEGG_PATHWAYS_IN_CANCER",-0.37667,-1.13,0.279,5628,0.458,"CDK2, CTNNA1, STAT3, ITGA2, GRB2, BRAF, DVL2, MITF, STAT5A, CTBP2, PIK3CB, CRK, RALBP1, NFKB1, MSH3, PLCG1, MMP2, RBX1, CUL2, AR, ELOC, ELOB, JAK1, AKT1, PIK3R1, TFG, PRKCA, MSH2, TRAF2, HSP90AB1, CASP8, PML, BCR, FADD, CHUK, MAPK3, ABL1, MLH1, HSP90AA1, RHOA, MAPK1, MET, ERBB2, BIRC5, CCDC6, NCOA4, BIRC2, PIK3R3, TRAF5, FAS, IKBKG, COL4A1, DAPK1, BID, HGF, SOS1, ITGA2B, CDK4, CKS1B, CDH1, STAT1, CCND1, ITGB1, EGFR, CRKL, PRKCB, TP53, LAMA3, LAMA4, TRAF1, RAC3, TPM3, TGFB1, ITGAV, PLCG2, TGFBR2, LAMB3, LAMB1, DAPK3, IKBKB, STK4, IL6, CDKN2A, PRKCG, RXRG, ITGA3, PTGS2, IGF1R, ETS1, RAC2",0.554395796726402,0.339134521996131,FALSE +"H520","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.40957,-1.23,0.192,5708,0.43,"GUSB, AKR1B1, UGP2, RPE, UGDH, XYLB",0.71669877129645,0.366531544420413,FALSE +"H520","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.4555,-1.38,0.129,5189,0.381,"TALDO1, TKT, H6PD, PGM2, ALDOC, RPE, FBP2, RBKS, RPIA, PFKL, G6PD, DERA, ALDOA, PGM1, PFKP",0.889410289700751,0.419075024324381,FALSE +"H520","Input","KEGG_PEROXISOME",0.30174,0.939,0.486,797,0.654,"PIPOX, PRDX1, SOD1, PECR, SLC27A2, MLYCD, PAOX, ACSL5, PEX12",0.313363730737707,0.184422251675733,FALSE +"H520","Input","KEGG_PHENYLALANINE_METABOLISM",0.73163,2.28,0.00487,282,0.224,"MAOB, ALDH3A1, MAOA, GOT2",2.31247103878537,0.649751981665837,TRUE +"H520","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.40811,-1.22,0.2,5775,0.421,"PIK3CB, OCRL, ITPKB, PLCG1, CDS2, DGKZ, PIK3R1, PRKCA, PIP4K2C, SYNJ2, CDS1, DGKH, PLCB3, PIK3R3, INPP1, PLCD3, PRKCB, PLCG2, ITPK1, IMPA2, ITPR3, ITPKA, PRKCG, INPP4B, DGKA",0.698970004336019,0.375717904164332,FALSE +"H520","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.28697,0.886,0.546,502,0.68,"UROD, FECH, EARS2",0.262807357295263,0.167491087293764,FALSE +"H520","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.2927,-0.871,0.563,6896,0.687,"SCP2, APOA1, ILK, DBI, LPL, ACSL4, SCD5, HMGCS2, FABP3, RXRG, PLTP",0.249491605148654,0.16304326294045,FALSE +"H520","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.63243,1.99,0.0156,654,0.256,"AKR1D1, CYP27A1",1.80687540164554,0.59176003468815,FALSE +"H520","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.39409,-1.16,0.249,6020,0.47,"TAP1, TAP2, ADA, CD40, IKBKG, ZAP70",0.603800652904264,0.327902142064283,FALSE +"H520","Input","KEGG_PRION_DISEASES",0.44472,1.38,0.113,217,0.297,"C9, NCAM1, SOD1",0.94692155651658,0.527243550682788,FALSE +"H520","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.38646,-1.15,0.266,5533,0.471,"AKT3, CDK2, BRAF, PIK3CB, CDC26, RPS6KA6, RPS6KA2, AKT1, PIK3R1, PRKACA, HSP90AB1, MAPK3, HSP90AA1, PLK1, MAPK1, CCNA2, PIK3R3, FZR1, CCNB1, RPS6KA1, MOS, ADCY9, IGF1R",0.575118363368933,0.326979092871104,FALSE +"H520","Input","KEGG_PROPANOATE_METABOLISM",0.46117,1.43,0.119,1311,0.266,"ACSS3, ALDH2, HIBCH, ALDH3A2, MLYCD, SUCLA2, PCCA, PCCB, ALDH7A1, ALDH9A1",0.924453038607469,0.575118363368933,FALSE +"H520","Input","KEGG_PROSTATE_CANCER",-0.30533,-0.914,0.538,5450,0.654,"RELA, CREB5, AKT3, CDK2, GRB2, BRAF, PIK3CB, NFKB1, AR, AKT1, PIK3R1, HSP90AB1, CHUK, MAPK3, HSP90AA1, MAPK1, ERBB2, PIK3R3, IKBKG, SOS1, CCND1, EGFR, TP53, IKBKB, IGF1R",0.269217724333611,0.184422251675733,FALSE +"H520","Input","KEGG_PROTEASOME",-0.42296,-1.26,0.195,4848,0.414,"PSMC2, PSMC5, PSMC4, PSMC6, PSMC3, PSMA8, PSMD4, PSMF1, PSMB2, PSMA4, PSMB1, PSMA6, PSMA5, PSMB7, PSMA1, PSMB6, PSMB8, PSMA2, PSMA7, PSMA3, PSMB3, PSME3, PSMB9",0.709965388637482,0.382999658879101,FALSE +"H520","Input","KEGG_PROTEIN_EXPORT",0.56486,1.74,0.035,2936,0.214,"SRP14, SEC63, SRPRB, SRP9, SEC62, SRPRA, SEC11C, SPCS2, SEC61A1, SPCS3, SRP19, SEC61B, SEC11A, SRP72, OXA1L",1.45593195564972,0.669586226650809,TRUE +"H520","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.37785,1.19,0.246,1973,0.437,"GLUD2, SLC25A10, PCK2, ATP1B1, ATP1B3, ATP1A3, ATP1A1, ATP1A4",0.609064892896621,0.359518563029578,FALSE +"H520","Input","KEGG_PURINE_METABOLISM",-0.21898,-0.673,0.878,6302,0.909,"PRIM1, POLD1, PKLR, AMPD2, NME6, PRIM2, POLD4, DCK, POLE3, NME7, ADA, POLE2, PFAS, CANT1, RRM2, IMPDH2, POLE, ADSL, ENPP1, NT5C2, IMPDH1, PNP, PAPSS2, AK1, AMPD3, ADCY9, POLR2F, NT5E",0.0565054840938974,0.0414361167780325,FALSE +"H520","Input","KEGG_PYRIMIDINE_METABOLISM",-0.31055,-0.925,0.495,6302,0.649,"PRIM1, POLD1, NME6, PRIM2, POLD4, UCKL1, DCTD, DCK, POLE3, NME7, TYMP, POLE2, CANT1, RRM2, POLE, NT5C2, CMPK1, PNP, DPYD, POLR2F, NT5E, UPP1, UPRT, CDA",0.305394801066431,0.187755303199631,FALSE +"H520","Input","KEGG_PYRUVATE_METABOLISM",0.25474,0.813,0.653,1862,0.776,"ALDH2, ALDH3A2, HAGH, ME1, PCK2, GRHPR, PKM, ALDH7A1, ALDH9A1, ME3, ALDH1B1, ACYP2, PDHA1",0.185086818724926,0.110138278741812,FALSE +"H520","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.46502,-1.39,0.142,6625,0.39,"WAS, PIP4K2C, MAPK3, ITGB3, DOCK1, RHOA, MAPK1, ACTN2, LIMK1, ACTN1, ROCK1, PIK3R3, ARHGAP35, ITGB5, ARPC1B, ENAH, SOS1, ARPC5, ITGA2B, SSH1, IQGAP2, PXN, CFL2, ITGB1, PPP1R12A, MYL12A, EGFR, CRKL, GSN, VAV2, SCIN, RAC3, VCL, ITGAV, BAIAP2, ITGA1, MOS, IQGAP3, EZR, MYH9, SSH3, MYH14, IQGAP1, PFN1, MYL9, GNG12, ITGA3, ITGB2, RRAS, ITGA5, RAC2, ITGB6",0.847711655616944,0.408935392973501,FALSE +"H520","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.27683,-0.847,0.612,5778,0.7,"ATG7, ATG12, ATG3, ATG5",0.213248577854439,0.154901959985743,FALSE +"H520","Input","KEGG_RENAL_CELL_CARCINOMA",-0.33678,-0.992,0.425,5533,0.561,"AKT3, PAK2, GRB2, BRAF, PIK3CB, CRK, RBX1, CUL2, ELOC, ELOB, AKT1, PIK3R1, MAPK3, MAPK1, MET, PIK3R3, HGF, SOS1, CRKL, TGFB1, ETS1",0.371611069949688,0.251037138743839,FALSE +"H520","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.36845,1.15,0.266,29,0.452,"MME",0.575118363368933,0.344861565188618,FALSE +"H520","Input","KEGG_RETINOL_METABOLISM",0.51088,1.57,0.0808,1421,0.262,"RDH11, ALDH1A1, PNPLA4, RETSAT, ALDH1A2",1.09258863922541,0.581698708680255,FALSE +"H520","Input","KEGG_RIBOFLAVIN_METABOLISM",0.36275,1.11,0.31,609,0.469,"RFK, MTMR2, ACP2",0.508638306165727,0.328827157284917,FALSE +"H520","Input","KEGG_RIBOSOME",0.153,0.479,0.995,3690,0.996,"RPL26L1, RPL37, RPS27A, RPL24, RSL24D1, RPS8, RPL22, RPL29, RPS6, MRPL13, RPL13, RPS15A, RPS3A, RPS7, RPS25, RPS24, RPL35A, RPL4, RPS10, RPS16, RPS13, RPL19, RPS4X, RPL6, RPL13A, RPL23, RPS23, RPL23A, RPL8, RPS9, RPL7, RPS18, RPS11, RPL34, RPL14, RPL30, RPL3, RPS2, FAU, RPL21, RPS20, RPL5",0.00217691925427455,0.00174066157630127,FALSE +"H520","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.48029,-1.43,0.0938,5897,0.373,"TBK1, NFKB1, AZI2, ATG12, NFKBIB, RIPK1, ATG5, TANK, TRAF2, CASP8, FADD, CHUK, TRADD, IKBKG, DDX58, IRF3, MAP3K7, IKBKB, ISG15",1.02779716162094,0.428291168191312,FALSE +"H520","Input","KEGG_RNA_DEGRADATION",0.22064,0.691,0.832,3163,0.896,"DCPS, HSPA9, ZCCHC7, MPHOSPH6, PARN, EXOSC10, MTREX, PAPOLG, EXOSC3, HSPD1, EXOSC1, LSM3, LSM2, CNOT10, EXOSC7, EDC3, EDC4, LSM1, CNOT2, DDX6, CNOT1, LSM4, EXOSC9, CNOT7, EXOSC5, DCP2, DCP1A",0.0798766737092761,0.0476919903378748,FALSE +"H520","Input","KEGG_RNA_POLYMERASE",0.30796,0.974,0.432,3081,0.604,"POLR2A, POLR3A, POLR2B, POLR2H, POLR1C, POLR1D, POLR2K, POLR1A, POLR1E, POLR2G, POLR2E, POLR1B, POLR2D, POLR3C, POLR2C, POLR2L",0.364516253185088,0.218963061378868,FALSE +"H520","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.26488,-0.785,0.717,5914,0.782,"SEPHS1, METTL2B, AHCY, AHCYL2, CTH, PAPSS2, GGT1",0.1444808443322,0.106793246940152,FALSE +"H520","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.5242,-1.57,0.0687,7025,0.385,"BIRC2, PIK3R3, TRAF5, IKBKG, COL4A1, ITGA2B, CDK4, CKS1B, CCND1, APAF1, ITGB1, TP53, LAMA3, LAMA4, TRAF1, ITGAV, LAMB3, LAMB1, IKBKB, RXRG, ITGA3, PTGS2",1.16304326294045,0.414539270491499,FALSE +"H520","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.33357,1.06,0.34,1370,0.53,"GOSR1, SEC22B, STX5, BET1L, BNIP1, STX2, VTI1B",0.468521082957745,0.275724130399211,FALSE +"H520","Input","KEGG_SPHINGOLIPID_METABOLISM",0.33427,1.04,0.345,1892,0.549,"SGPL1, GALC, PLPP2, PLPP1, ARSA, SMPD4, DEGS1, SMPD1",0.462180904926726,0.260427655549908,FALSE +"H520","Input","KEGG_SPLICEOSOME",0.46963,1.5,0.0723,3233,0.253,"HNRNPU, RBMX, PRPF38B, PRPF38A, ALYREF, U2SURP, THOC2, DDX5, SNRPA, ACIN1, TRA2B, XAB2, HNRNPA1, SF3A2, PPIE, HNRNPM, PRPF40B, THOC1, SNRPA1, PRPF8, SNRNP200, AQR, SRSF6, RBM17, SF3B1, ZMAT2, SRSF9, CDC5L, HNRNPA3, TXNL4A, SNW1, SNRNP27, PRPF40A, CHERP, SART1, RBM22, BUD31, SRSF2, SNRPB2, SRSF4, PRPF31, SRSF1, EFTUD2, SF3B3, SRSF3, SF3B6, DDX39B, CTNNBL1, SLU7, SRSF5, SNU13, SRSF10, PRPF19, PLRG1, USP39, CDC40, MAGOHB, SNRPD1, SNRPD2, SNRNP40, SNRPD3, THOC3, EIF4A3, LSM3, LSM2, PRPF18, PUF60, SF3A3, DDX23, SMNDC1, HNRNPK, ISY1, PRPF6, DHX8, NCBP1, RBM8A, CRNKL1, DDX46, DHX15, SRSF8, SRSF7, CWC15, U2AF1, DHX16, LSM4, DHX38, PHF5A, RBM25, HNRNPC, SNRPC, PRPF3, SF3A1, TCERG1, TRA2A, SNRPE, BCAS2, U2AF2, PRPF4",1.14086170270547,0.596879478824182,FALSE +"H520","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.43117,-1.3,0.165,7280,0.428,"ENPP1, UGDH, PYGB, PGM1, SI",0.782516055786094,0.368556230986828,FALSE +"H520","Input","KEGG_STEROID_BIOSYNTHESIS",-0.36819,-1.09,0.31,4944,0.488,"CEL, LIPA, SOAT1, CYP51A1, FDFT1, NSDHL, SOAT2, LSS, DHCR24, MSMO1",0.508638306165727,0.311580177997289,FALSE +"H520","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.6384,2.02,0.0211,391,0.298,"AKR1C2, AKR1C1, AKR1D1, AKR1C3, HSD17B8, HSD17B12",1.67571754470231,0.525783735923745,FALSE +"H520","Input","KEGG_SULFUR_METABOLISM",-0.55996,-1.74,0.0287,7088,0.638,"SULT1A3, PAPSS2, SULT2B1, CHST12",1.54211810326601,0.195179321278838,FALSE +"H520","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.35929,1.12,0.286,357,0.468,"C9, C4A",0.543633966870957,0.329754146925876,FALSE +"H520","Input","KEGG_TASTE_TRANSDUCTION",-0.28496,-0.851,0.629,7599,0.7,"CACNA1A, ITPR3",0.201349354554731,0.154901959985743,FALSE +"H520","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.45822,-1.4,0.128,4926,0.388,"IDI1, HMGCS1, ACAT1, HMGCR, PMVK, MVK, ACAT2, PDSS2, MVD, FDPS, DHDDS, HMGCS2",0.892790030352132,0.411168274405793,FALSE +"H520","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.27686,0.882,0.593,44,0.674,"INHBE, TGFB2",0.226945306635737,0.17134010346468,FALSE +"H520","Input","KEGG_THYROID_CANCER",-0.48955,-1.46,0.0972,6679,0.373,"MAPK3, MAPK1, CCDC6, NCOA4, CDH1, CCND1, TP53, TPM3, RXRG",1.01233373507373,0.428291168191312,FALSE +"H520","Input","KEGG_TIGHT_JUNCTION",-0.42686,-1.27,0.193,5970,0.444,"PPP2R1A, PATJ, ACTN4, MAP3K20, OCLN, HCLS1, ACTB, TJAP1, AKT1, PPP2R2A, PRKCA, MYH10, LLGL1, PRKCI, EXOC4, RHOA, ACTN2, PARD3, CTTN, ACTN1, CLDN11, EXOC3, CDK4, TJP2, MYL12A, TJP3, PRKCB, CGN, MYH11, MYH9, MYH14, MYH7B, PRKCD, MYL9, PARD6B, AMOTL1, PRKCQ, PARD6G, CLDN4, PRKCG, RRAS, CLDN6",0.714442690992226,0.35261702988538,FALSE +"H520","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.34888,-1.04,0.382,5420,0.525,"TOLLIP, RELA, AKT3, TLR9, PIK3CB, TBK1, NFKB1, IRAK4, IFNAR1, RIPK1, AKT1, PIK3R1, TAB1, CASP8, FADD, MYD88, CHUK, MAPK3, MAPK1, CD40, PIK3R3, IKBKG, STAT1, IRF3, TAB2, MAP3K7, IKBKB, IL6",0.417936637088291,0.279840696594043,FALSE +"H520","Input","KEGG_TRYPTOPHAN_METABOLISM",0.5571,1.71,0.0382,535,0.219,"MAOB, ALDH2, WARS2, MAOA, ALDH3A2, AADAT",1.41793663708829,0.659555885159882,TRUE +"H520","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.41814,-1.26,0.183,6303,0.414,"PIK3R1, PKLR, MAPK3, MAPK1, IRS2, PIK3R3, CACNA1A, IRS1, PRKCD, IKBKB",0.737548910269571,0.382999658879101,FALSE +"H520","Input","KEGG_TYROSINE_METABOLISM",0.49964,1.58,0.0787,725,0.27,"MAOB, ALDH3A1, MAOA, GOT2, TRMT11, GSTZ1",1.10402526764094,0.568636235841013,FALSE +"H520","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.41643,-1.26,0.183,5634,0.414,"PAK2, GRB2, PTPN6, PIK3CB, PPP3CB, NFKB1, PPP3CA, PLCG1, NFKBIB, AKT1, PIK3R1, NFATC2, BCL10, CHUK, MAPK3, RHOA, MAPK1, PIK3R3, IKBKG, SOS1, CDK4, MAP3K7, ZAP70, VAV2, PPP3R1, IKBKB, PRKCQ, CARD11",0.737548910269571,0.382999658879101,FALSE +"H520","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.33138,-0.993,0.411,5714,0.566,"UBE2G2, WWP1, CDC26, UBE2E2, BIRC6, FANCL, UBE2J2, UBA6, RBX1, CUL2, ELOC, UBE2Q1, FBXO2, ELOB, SMURF2, STUB1, UBE2S, UBE3C, RCHY1, PML, ITCH, UBE2M, UBE2G1, UBE2F, BRCA1, UBA1, BIRC2, UBE4B, UBE2H, FZR1, UBE2L3, NEDD4L, TRIM32, DDB2, UBOX5, UBE2E3, UBA7, UBE2C",0.386158178123931,0.247183568811729,FALSE +"H520","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.28191,0.896,0.535,2738,0.676,"LARS2, PDHA1, PDHB, BCAT1",0.271646217978772,0.170053304058364,FALSE +"H520","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.40491,1.25,0.193,2272,0.374,"ACAA2, ALDH2, HIBCH, ACAD8, ALDH3A2, MCCC1, BCKDHB, IVD, PCCA, PCCB, ALDH7A1, ALDH9A1, HSD17B10, BCKDHA, ALDH1B1, MCEE, OXCT1, HADH, HADHA, ECHS1, ALDH6A1, MCCC2, 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0000000..30a662d --- /dev/null +++ b/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_interactive_network.graph.html @@ -0,0 +1,5318 @@ + + + + +visNetwork + + + + + + + +

+
+
+ + + + diff --git a/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_mean_results.csv b/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..6a0db61 --- /dev/null +++ b/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"MDM inhibitor",0.61505,1.2322415379684,0.000145116304689573,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"HCC95, H1648, HCC827, H2009",0.000708509017013798 +"retinoid receptor agonist",0.5428,1.3641660880514,1.54628289517376e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"H1648, H2126, HCC44",9.87242156149402e-05 +"bacterial DNA gyrase inhibitor",0.53395,1.11615238890716,0.0138837300852224,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC4006",0.0371725676475311 +"adrenergic receptor antagonist",0.4275,0.704636487096268,0.999709613483481,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055 +"benzodiazepine receptor agonist",0.3917,0.791587352628947,0.995411169605698,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055 +"BCL inhibitor",0.37655,1.16843775480002,0.0451365090014476,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC44",0.0985876380821093 +"sterol demethylase inhibitor",0.3461,1.19563305847836,0.032389666410513,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H2009",0.0746761753353493 +"acetylcholine receptor antagonist",0.29795,1.35306044813814,0.00304025399837317,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"HCC4006, H460, H1299",0.0097054262255759 +"DNA inhibitor",0.267,0.8149782044228,0.998636801435584,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055 +"bromodomain inhibitor",0.266,2.01562423398598,5.13300386315732e-11,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,14,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2009, HCC2279, H520, HCC15, H460, HCC44, H1299",4.26039320642058e-09 +"TGF beta receptor inhibitor",0.22885,1.10245201709644,0.214936822386624,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.356795125161795 +"PPAR receptor agonist",0.21995,1.02146708090296,0.531887171536959,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.723715331763403 +"PI3K inhibitor",0.1995,1.10661786776789,0.363837156977989,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H1648, HCC44",0.549063345984966 +"HMGCR inhibitor",0.14345,2.0513456809206,1.30308365978555e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,12,"H358, H1650, H3255, H1975, HCC78, H2126, H2009, HCC4006, HCC2279, HCC15, HCC44, H1299",9.01299531351674e-05 +"proteasome inhibitor",0.1258,1.07236696389956,0.590378029141691,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"A549",0.75386732951939 +"ATPase inhibitor",0.12365,0.968844850704612,0.90694560812152,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055 +"PARP inhibitor",0.1064,1.18423519178991,0.0598434586043851,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC2279",0.124175176604099 +"protein synthesis inhibitor",0.1008,1.15083715981934,0.18548285284487,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.320730766377588 +"glutamate receptor antagonist",0.09955,1.32616127760183,0.00250856020606875,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H1650, HCC78, H2009, HCC15",0.00832841988414826 +"vitamin D receptor agonist",0.0962,1.34228362364881,0.00034220015351446,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC44",0.00143573185379231 +"calcium channel blocker",0.0774500000000001,1.32676716217714,0.00099955407026891,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC2279",0.00377104490146907 +"RET tyrosine kinase inhibitor",0.0774000000000001,1.54086525248504,5.77785175903458e-08,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,7,"H1648, HCC78, H2126, HCC2279, HCC15, HCC44, H1299",9.5912339199974e-07 +"p38 MAPK inhibitor",0.0754000000000001,1.18790458592564,0.0663809593809252,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H520",0.131181419728971 +"DNA methyltransferase inhibitor",0.0721,1.49604101759136,1.47474728750385e-08,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,7,"H358, H3255, H1648, HCC78, H2009, HCC4006, HCC15",3.0601006215705e-07 +"ribonucleotide reductase inhibitor",0.0639,0.914222355769904,0.976855965003178,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055 +"serotonin receptor antagonist",0.0465500000000001,1.14335487307724,0.265645268308797,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.424010716723657 +"sodium channel blocker",0.03555,1.00664452906413,0.851671294227971,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.969566778409323 +"tubulin polymerization inhibitor",0.0320499999999999,1.28920136334987,0.00161975489504299,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"HCC2279, H520, H460",0.00584520244732904 +"FGFR inhibitor",0.0276500000000001,1.23469119407925,0.0246238115000805,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H1648",0.061643404745328 +"VEGFR inhibitor",0.0246,1.05729537773958,0.647286672796522,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.814012027910777 +"cyclooxygenase inhibitor",0.01715,0.740179300824078,0.999997150505055,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055 +"PLK inhibitor",0.0106500000000001,1.58124036173472,3.58239250709438e-09,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,9,"H1650, H3255, HCC78, H2126, HCC2279, H520, HCC15, H460, H1299",1.18409164929212e-07 +"AKT inhibitor",-0.00365000000000006,1.43010192036497,3.60853205436968e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H1648, HCC4006, HCC2279, HCC15",4.27868800732405e-05 +"adenosine receptor antagonist",-0.00470000000000001,1.3338381145362,0.00808035904655401,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H3255, H1975",0.0239524928879994 +"PDGFR tyrosine kinase receptor inhibitor",-0.00715000000000001,1.10921737582951,0.391200964864684,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.579815715781585 +"mTOR inhibitor",-0.0165000000000001,1.15589334328589,0.195376986808872,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.330944691941559 +"Aurora kinase inhibitor",-0.04585,1.48762743903453,4.27984933479079e-09,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,7,"H1650, H1648, HCC78, HCC4006, HCC2279, HCC15, H460",1.18409164929212e-07 +"topoisomerase inhibitor",-0.0461,1.17780106889692,0.0617206725813804,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H1648, HCC2279",0.124946727420843 +"estrogen receptor agonist",-0.0583,1.20994223872573,0.0791436753718466,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC2279",0.14929375126962 +"HSP inhibitor",-0.0634,1.08178801308905,0.464466540081523,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.664667634944248 +"KIT inhibitor",-0.0641,1.07961249870888,0.483109466556363,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.668301428736302 +"RAF inhibitor",-0.09,1.25110431219783,0.0109903797655942,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H1299",0.0304067173514772 +"EGFR inhibitor",-0.0909,1.02185244068129,0.481790835582359,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC4006",0.668301428736302 +"FLT3 inhibitor",-0.0982,1.21462771424438,0.0194905268913824,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H1299",0.0505535541245232 +"cytochrome P450 inhibitor",-0.1031,1.60203179875136,3.3913576132178e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,6,"H358, H1650, H3255, H1648, HCC2279, H460",4.27868800732405e-05 +"phosphatase inhibitor",-0.10515,0.967201621336415,0.933978258295636,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055 +"estrogen receptor antagonist",-0.11125,1.13639674664682,0.157459892823631,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC44",0.284112415312204 +"DNA polymerase inhibitor",-0.13405,0.999527334346221,0.844759851827795,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.969566778409323 +"opioid receptor agonist",-0.1425,1.39185379979364,0.000241539618550126,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H358, H1650, H1648, H2126",0.00111376601887003 +"glucocorticoid receptor agonist",-0.1607,1.10130420769864,0.236217488060158,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.384432382529277 +"dopamine receptor antagonist",-0.1984,0.86542380247757,0.994897841851579,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055 +"NFkB pathway inhibitor",-0.2011,1.05578481160749,0.453102960313756,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.659781503614768 +"bacterial 50S ribosomal subunit inhibitor",-0.21955,0.997874133767433,0.742636125088984,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.906452917388025 +"microtubule inhibitor",-0.22795,1.10401475366763,0.170869477035346,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H460",0.301748225402845 +"thymidylate synthase inhibitor",-0.2299,1.35964449300853,1.10798782454047e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H1648, HCC78",8.36027176698718e-05 +"histamine receptor antagonist",-0.23975,0.759926442077403,0.999963892942649,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055 +"androgen receptor antagonist",-0.24695,1.65162629502592,4.91157477484915e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,8,"H3255, H1648, HCC4006, HCC2279, HCC15, H460, H1703, H1299",5.095758828906e-05 +"potassium channel blocker",-0.24845,1.16754260488024,0.109222904832103,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H3255",0.201455580023657 +"HCV inhibitor",-0.25855,1.08147864056578,0.34269014386723,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.526727443351483 +"phosphodiesterase inhibitor",-0.26055,1.03700172435526,0.561418319585173,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.751576137509183 +"growth factor receptor inhibitor",-0.27215,1.30130615658188,0.00034595948284152,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H520, H1299",0.00143573185379231 +"adrenergic receptor agonist",-0.28245,0.988356662397367,0.727267485057901,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.90094330238516 +"DNA synthesis inhibitor",-0.28955,0.949400723725512,0.881529688425416,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.988742758639318 +"DNA alkylating agent",-0.2977,1.02007466702972,0.587133701708533,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.75386732951939 +"serotonin receptor agonist",-0.30305,1.34232298548763,0.00403539258321259,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H1975, H520, A549, H1299",0.0124050957187646 +"ALK tyrosine kinase receptor inhibitor",-0.30705,0.935512551605015,0.852751503902176,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.969566778409323 +"tyrosine kinase inhibitor",-0.3289,0.964588589694291,0.756086717032928,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.909495616141059 +"JAK inhibitor",-0.3435,1.00415796094355,0.575097989039066,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.75386732951939 +"protein tyrosine kinase inhibitor",-0.36185,1.200645847034,0.00229379431815644,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"H358, H3255, HCC4006",0.00793270535029103 +"HDAC inhibitor",-0.36835,1.31120656668822,0.000556338731126338,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"HCC78, HCC2279, HCC15",0.00219886260397553 +"CC chemokine receptor antagonist",-0.3728,1.1581719079744,0.0409854160979159,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0919402577331627 +"CDK inhibitor",-0.3777,1.37443546688507,1.10405361480619e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,5,"H358, HCC78, HCC2279, H460, H1299",8.36027176698718e-05 +"AP inhibitor",-0.4205,1.50089876582771,2.26144961223966e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,7,"H358, H1650, H2126, CALU3, HCC15, A549, HCC44",0.00013407165558278 +"src inhibitor",-0.57995,1.09395513595105,0.0252515151968814,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H1975",0.061643404745328 +"progesterone receptor agonist",-0.5833,1.0214453691242,0.0588040918242428,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H1648, H1975",0.124175176604099 +"Bcr.Abl kinase inhibitor",-0.5874,1.11023323296456,0.0266088170838195,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H520",0.0631009090844861 +"MET inhibitor",-0.63625,1.38278665534873,2.70772064645311e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,6,"H1650, HCC95, H3255, H1648, H1975, H520",0.000149827209103739 +"glycogen synthase kinase inhibitor",-0.6492,0.768857635169148,0.790305414936758,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.93707642056787 +"Abl kinase inhibitor",-0.67955,0.981613198287712,0.077184141256562,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H1975",0.148983342425457 +"MEK inhibitor",-0.75255,0.777958832289243,0.293282217627469,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC827",0.459291020058112 +"CHK inhibitor",-0.8106,1.22841744147758,9.20604740145148e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"HCC95, H1975, HCC827, HCC44",8.36027176698718e-05 +"acetylcholine receptor agonist",-0.8695,0.888479511359301,0.0101420833981925,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H460",0.0290273421396545 +"antioxidant",-0.9436,1.03873867844866,9.07240468663416e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H1650, H1648, H1975, HCC2279",0.000470630993119147 diff --git a/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_results.csv b/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_results.csv new file mode 100644 index 0000000..1cb1524 --- /dev/null +++ b/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_results.csv @@ -0,0 +1,1661 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"H358","Pearson.est","EGFR inhibitor",-0.6517,-1.55,0.031,1083,0.321,"BIBX.1382, poziotinib, tyrphostin.AG.1478, AEE788, BMS.690514, WZ8040, WZ.4002, lapatinib, erlotinib, CP.724714, canertinib, pelitinib, rociletinib, BMS.599626, TAK.285, PD.153035, gefitinib, dacomitinib, XL.647, GW.583340, AZD8931, tucatinib, BIBU.1361, osimertinib, afatinib, CUDC.101, neratinib, ARRY.334543, AST.1306",1.50863830616573,0.493494967595128,FALSE +"H358","Pearson.est","Abl kinase inhibitor",-0.38684,-0.915,0.6,1017,0.807,"ZM.306416, imatinib, tozasertib, bafetinib, bosutinib, KW.2449",0.221848749616356,0.0931264652779296,FALSE +"H358","Pearson.est","acetylcholine receptor agonist",-0.58163,-1.4,0.102,1016,0.47,"xanomeline, nefiracetam, pilocarpine",0.991399828238082,0.327902142064283,FALSE +"H358","Pearson.est","acetylcholine receptor antagonist",0.47989,1.44,0.117,756,0.299,"darifenacin, iododexetimide, hyoscyamine, methscopolamine, diphemanil, dicycloverine",0.931814138253838,0.52432881167557,FALSE +"H358","Pearson.est","adenosine receptor antagonist",-0.44247,-1.06,0.397,729,0.742,"istradefylline, SCH.58261, PSB.1115, MRS.1220, CGS.15943",0.401209493236885,0.129596094720973,FALSE +"H358","Pearson.est","adrenergic receptor agonist",0.24075,0.726,0.765,1103,0.903,"lidamidine, xylazine, epinephrine, terbutaline, methyldopa, oxymetazoline, ritodrine, A61603, norepinephrine, buphenine, isoetharine, midodrine, clenbuterol, metaraminol, isoxsuprine",0.116338564846382,0.0443122496864942,FALSE +"H358","Pearson.est","adrenergic receptor antagonist",-0.27247,-0.65,0.91,691,0.974,"carvedilol, propranolol, oxprenolol, dihydroergocristine, prazosin, levobunolol, vincamine, dronedarone, atenolol......, naftidrofuryl, atipamezole",0.0409586076789064,0.0114410431213845,FALSE +"H358","Pearson.est","AKT inhibitor",-0.61414,-1.47,0.0535,1030,0.374,"palomid.529, AZD5363, CCT128930, GSK2110183, GDC.0068, A.674563, triciribine, uprosertib",1.27164621797877,0.42712839779952,FALSE +"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.30241,-0.719,0.846,822,0.974,"AP26113, NVP.TAE684, alectinib, CEP.37440, DMH1, AZD3463",0.0726296369609765,0.0114410431213845,FALSE +"H358","Pearson.est","androgen receptor antagonist",0.42025,1.29,0.165,842,0.401,"bicalutamide, RU.58841, flutamide, cyproterone.acetate, nilutamide, enzalutamide",0.782516055786094,0.396855627379818,FALSE +"H358","Pearson.est","antioxidant",0.30374,0.96,0.489,1010,0.704,"rutin, trolox, mesna, benfotiamine, chlorogenic.acid, taurine",0.31069114087638,0.152427340857888,FALSE +"H358","Pearson.est","AP inhibitor",0.60909,1.79,0.0294,51,0.212,"birinapant, GDC.0152, idronoxil",1.53165266958784,0.673664139071249,TRUE +"H358","Pearson.est","ATPase inhibitor",-0.24609,-0.58,0.932,1164,0.99,"NMS.873, oligomycin.a, evodiamine",0.0305840876460186,0.00436480540245009,FALSE +"H358","Pearson.est","Aurora kinase inhibitor",-0.68507,-1.63,0.0284,1072,0.25,"GSK1070916, aurora.a.inhibitor.i, tozasertib, barasertib, ENMD.2076, danusertib, AMG900, PF.03814735, PHA.680632, CYC116, alisertib, ZM.447439, KW.2449, MK.8745, AT.9283, hesperadin, barasertib.HQPA, SNS.314, CCT137690",1.54668165995296,0.602059991327962,FALSE +"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.46955,-1.13,0.312,814,0.683,"tilmicosin, azithromycin, tedizolid, valnemulin, radezolid, azalomycin.b",0.505845405981557,0.165579296318467,FALSE +"H358","Pearson.est","bacterial DNA gyrase inhibitor",0.36234,1.13,0.295,144,0.612,"sparfloxacin, lomefloxacin, sarafloxacin",0.530177984021837,0.213248577854439,FALSE +"H358","Pearson.est","BCL inhibitor",-0.38984,-0.942,0.528,1292,0.79,"TW.37, gossypol",0.277366077466188,0.102372908709559,FALSE +"H358","Pearson.est","Bcr.Abl kinase inhibitor",-0.29645,-0.713,0.843,1037,0.963,"imatinib, tozasertib, bafetinib, bosutinib",0.0741724253752577,0.0163737128754655,FALSE +"H358","Pearson.est","benzodiazepine receptor agonist",0.22134,0.702,0.87,174,0.837,"gamma.aminobutyric.acid, eprinomectin, indiplon, CL.218872",0.0604807473813815,0.07727454200674,FALSE +"H358","Pearson.est","bromodomain inhibitor",-0.89875,-2.17,0,1296,0.00089,"PFI.1, bromosporine, I.BET.762, I.BET151, JQ1...., OTX015",Inf,3.05060999335509,TRUE +"H358","Pearson.est","calcium channel blocker",-0.419,-0.991,0.503,1057,0.779,"mibefradil, penfluridol, tetrandrine, cinnarazine, carboxyamidotriazole",0.298432014944073,0.108462542327436,FALSE +"H358","Pearson.est","CC chemokine receptor antagonist",-0.4256,-1.02,0.455,1252,0.753,"SB.225002, ZK811752",0.341988603342888,0.123205023799299,FALSE +"H358","Pearson.est","CDK inhibitor",-0.78518,-1.87,0,1228,0.0565,"indirubin, ribociclib, aminopurvalanol.a, PHA.793887, R547, alvocidib, JNJ.7706621, abemaciclib, arcyriaflavin.a, P276.00, indisulam, palbociclib, AZD5438, kenpaullone, BMS.265246, AT.7519, dinaciclib, TG.02, BMS.387032",Inf,1.24795155218056,TRUE +"H358","Pearson.est","CHK inhibitor",0.23134,0.72,0.865,256,0.861,"SCH.900776, PF.477736, AZD7762",0.0629838925351858,0.0649968485463452,FALSE +"H358","Pearson.est","cyclooxygenase inhibitor",-0.23974,-0.575,0.949,1086,0.977,"phenazone, ketoprofen, ramifenazone, FR.122047, tryptanthrin, aspirin",0.0227337875727074,0.0101054362812269,FALSE +"H358","Pearson.est","cytochrome P450 inhibitor",0.55833,1.67,0.0229,212,0.182,"eplerenone, metyrapone, clotrimazole, morin",1.64016451766011,0.739928612014925,TRUE +"H358","Pearson.est","DNA alkylating agent",-0.39064,-0.942,0.555,1079,0.79,"estramustine, streptozotocin, cyclophosphamide, TH.302, mitomycin.c",0.255707016877324,0.102372908709559,FALSE +"H358","Pearson.est","DNA inhibitor",-0.328,-0.787,0.751,1390,0.919,"oxaliplatin, primaquine",0.124360062995832,0.0366844886138887,FALSE +"H358","Pearson.est","DNA methyltransferase inhibitor",-0.70221,-1.67,0.0161,1311,0.231,"decitabine, fdcyd, azacitidine",1.79317412396815,0.636388020107856,TRUE +"H358","Pearson.est","DNA polymerase inhibitor",-0.39424,-0.942,0.555,1302,0.79,"trifluridine, idoxuridine",0.255707016877324,0.102372908709559,FALSE +"H358","Pearson.est","DNA synthesis inhibitor",-0.53334,-1.26,0.184,1389,0.603,"anisomycin, cyclocytidine, mitomycin.c",0.735182176990464,0.219682687859849,FALSE +"H358","Pearson.est","dopamine receptor antagonist",-0.3963,-0.939,0.558,896,0.778,"piperacetazine, mesoridazine, paliperidone, lurasidone, UH.232...., acetophenazine, thioproperazine, sertindole",0.253365801062421,0.109020403010311,FALSE +"H358","Pearson.est","estrogen receptor agonist",0.2875,0.855,0.647,1034,0.853,"estradiol.cypionate, ethinyl.estradiol, PPT, equol, estrone, estradiol, erteberel, levonorgestrel",0.1890957193313,0.069050968832477,FALSE +"H358","Pearson.est","estrogen receptor antagonist",-0.54697,-1.31,0.145,1419,0.533,"clomifene",0.838631997765025,0.273272790973428,FALSE +"H358","Pearson.est","FGFR inhibitor",0.28032,0.851,0.603,117,0.801,"lenvatinib, erdafitinib, dovitinib",0.219682687859849,0.0963674839157623,FALSE +"H358","Pearson.est","FLT3 inhibitor",-0.48381,-1.16,0.251,956,0.677,"GTP.14564, tandutinib, TG.101348, lestaurtinib, tozasertib, ENMD.2076, KW.2449, sorafenib, TG.02, pacritinib",0.600326278518962,0.169411331314856,FALSE +"H358","Pearson.est","glucocorticoid receptor agonist",-0.50407,-1.21,0.227,949,0.649,"fludroxycortide, dexamethasone.acetate, prednisolone, halcinonide, clobetasol.propionate, triamcinolone.acetonide, betamethasone, desonide, prednisolone.hemisuccinate, flumethasone.pivalate, difluprednate, methylprednisolone, ciclesonide, halobetasol.propionate, flumethasone, deflazacort, rimexolone",0.643974142806877,0.187755303199631,FALSE +"H358","Pearson.est","glutamate receptor antagonist",0.51154,1.51,0.0923,94,0.272,"latrepirdine, CGP.37849, JNJ.16259685, kynurenic.acid",1.03479829897409,0.565431095965801,FALSE +"H358","Pearson.est","glycogen synthase kinase inhibitor",-0.29618,-0.702,0.848,1228,0.942,"indirubin, kenpaullone",0.0716041477432862,0.0259490972071227,FALSE +"H358","Pearson.est","growth factor receptor inhibitor",-0.59569,-1.43,0.078,967,0.433,"GSK1838705A, GSK1904529A, lestaurtinib, PHA.848125, danusertib, AZD3463",1.10790539730952,0.363512103646635,FALSE +"H358","Pearson.est","HCV inhibitor",-0.45754,-1.09,0.349,887,0.736,"Ro.9187, PSI.7976, mericitabine, narlaprevir",0.45717457304082,0.133122185662501,FALSE +"H358","Pearson.est","HDAC inhibitor",-0.52434,-1.25,0.208,1149,0.573,"resminostat, SB.939, AR.42, PCI.24781, trichostatin.a, belinostat, dacinostat, RG2833, vorinostat, scriptaid, givinostat, M.344, R306465",0.681936665037238,0.24184537803261,FALSE +"H358","Pearson.est","histamine receptor antagonist",-0.22251,-0.535,0.969,763,0.967,"pheniramine, ebastine, BF2.649, cyproheptadine, famotidine, levocetirizine, astemizole, tiotidine, terfenadine",0.0136762229492347,0.0145735259169983,FALSE +"H358","Pearson.est","HMGCR inhibitor",0.94707,2.79,0,55,0,"pitavastatin, fluvastatin, atorvastatin, mevastatin, simvastatin",Inf,Inf,TRUE +"H358","Pearson.est","HSP inhibitor",-0.50178,-1.2,0.229,941,0.62,"BIIB021, SNX.5422, NVP.AUY922, PU.H71, XL888, alvespimycin, tanespimycin",0.640164517660112,0.207608310501746,FALSE +"H358","Pearson.est","JAK inhibitor",-0.53277,-1.26,0.188,943,0.603,"WHI.P154, TG.101348, LY2784544, lestaurtinib, tozasertib, atiprimod, filgotinib, AZ960, TG.101209, AT.9283, TG.02, pacritinib",0.72584215073632,0.219682687859849,FALSE +"H358","Pearson.est","KIT inhibitor",-0.34403,-0.821,0.708,948,0.884,"vatalanib, tandutinib, imatinib, pazopanib, regorafenib, sorafenib, OSI.930",0.149966742310231,0.0535477349869269,FALSE +"H358","Pearson.est","MDM inhibitor",0.26352,0.769,0.757,1068,0.896,"AMG.232, idasanutlin, CGM097, nutlin.3, RITA, serdemetan",0.120904120499927,0.0476919903378748,FALSE +"H358","Pearson.est","MEK inhibitor",-0.55349,-1.32,0.13,916,0.574,"nobiletin, TAK.733, refametinib, Ro.4987655, selumetinib, arctigenin, PD.198306, PD.184352, cobimetinib, AS.703026, PD.0325901, AZD8330, MEK162, trametinib",0.886056647693163,0.241088107602027,FALSE +"H358","Pearson.est","MET inhibitor",0.46186,1.38,0.0738,782,0.332,"PF.04217903, LY2801653, PHA.665752, AMG458, NVP.BVU972, INC.280",1.13194363817696,0.478861916295964,FALSE +"H358","Pearson.est","microtubule inhibitor",-0.56639,-1.37,0.105,914,0.475,"colchicine, cytochalasin.b, podophyllotoxin, cabazitaxel, vinflunine, D.64131",0.978810700930062,0.323306390375133,FALSE +"H358","Pearson.est","mTOR inhibitor",-0.452,-1.08,0.363,1020,0.715,"XL388, palomid.529, PP242, ku.0063794, WYE.354, torin.2, MLN0128, AZD2014, GDC.0980, AZD8055, WYE.125132, GSK2126458",0.440093374963888,0.145693958198919,FALSE +"H358","Pearson.est","NFkB pathway inhibitor",-0.46941,-1.13,0.288,797,0.683,"parthenolide, tyloxapol, curcumin, Ro.106.9920, parthenolide...., bortezomib, IKK.2.inhibitor.V, EVP4593, betulinic.acid",0.540607512240769,0.165579296318467,FALSE +"H358","Pearson.est","opioid receptor agonist",0.5422,1.69,0.0365,56,0.22,"BW.180C, spiradoline",1.43770713554353,0.657577319177794,TRUE +"H358","Pearson.est","p38 MAPK inhibitor",-0.48825,-1.16,0.287,859,0.677,"CMPD.1, skepinone.l, SB.242235, SB.239063, talmapimod",0.542118103266008,0.169411331314856,FALSE +"H358","Pearson.est","PARP inhibitor",-0.37067,-0.883,0.627,664,0.849,"E7449, AG.14361, PJ.34, talazoparib, olaparib, niraparib",0.202732459169284,0.0710923097560473,FALSE +"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.237,-0.561,0.956,919,0.97,"trapidil, vatalanib, tandutinib, imatinib, crenolanib, pazopanib, regorafenib, sorafenib",0.0195421077238999,0.0132282657337552,FALSE +"H358","Pearson.est","phosphatase inhibitor",-0.43067,-1.03,0.439,1085,0.75,"GSK2830371, alexidine, CID.5458317, mycophenolic.acid, mycophenolate.mofetil",0.357535479757879,0.1249387366083,FALSE +"H358","Pearson.est","phosphodiesterase inhibitor",0.36231,1.04,0.399,927,0.605,"anagrelide, GSK256066, enoximone, YM.976, zardaverine, EMD.53998, cilostamide, papaverine, avanafil, trequinsin",0.399027104313252,0.218244625347531,FALSE +"H358","Pearson.est","PI3K inhibitor",-0.36681,-0.877,0.64,786,0.842,"LY303511, BGT226, NVP.BEZ235, voxtalisib, PI3K.IN.2, buparlisib, YM.201636, CUDC.907, CH5132799, GDC.0980, alpelisib, taselisib, TG.100713, PIK.75, GSK2126458",0.193820026016113,0.0746879085003505,FALSE +"H358","Pearson.est","PLK inhibitor",-0.55106,-1.31,0.136,910,0.533,"rigosertib, HMN.214, NMS.1286937, volasertib, BI.2536, GW.843682X",0.866461091629782,0.273272790973428,FALSE +"H358","Pearson.est","potassium channel blocker",0.36457,1.08,0.333,210,0.587,"dofetilide, mepivacaine, meglitinide, ibutilide",0.47755576649368,0.231361898752386,FALSE +"H358","Pearson.est","PPAR receptor agonist",-0.45252,-1.08,0.392,1089,0.715,"ciprofibrate, GW.501516, oleoylethanolamide",0.406713932979543,0.145693958198919,FALSE +"H358","Pearson.est","progesterone receptor agonist",-0.29131,-0.702,0.85,1033,0.942,"levonorgestrel, dienogest, melengestrol.acetate",0.0705810742857073,0.0259490972071227,FALSE +"H358","Pearson.est","proteasome inhibitor",-0.34957,-0.836,0.702,766,0.896,"ixazomib, carfilzomib, ixazomib.citrate, ONX.0914, bortezomib",0.153662887870195,0.0476919903378748,FALSE +"H358","Pearson.est","protein synthesis inhibitor",-0.31767,-0.772,0.798,1282,0.923,"harringtonine, homoharringtonine, bruceantin, anguidine",0.0979971086492706,0.0347982989740879,FALSE +"H358","Pearson.est","protein tyrosine kinase inhibitor",-0.70229,-1.7,0.0128,1130,0.236,"mubritinib, AV.412, CP.724714, BMS.599626, tyrphostin.A9, NVP.TAE226",1.89279003035213,0.627087997029893,TRUE +"H358","Pearson.est","RAF inhibitor",-0.5809,-1.38,0.0967,1069,0.484,"GDC.0879, SB.590885, PLX.4720, regorafenib, RAF265, TAK.632, sorafenib",1.014573525917,0.315154638355588,FALSE +"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.61831,-1.47,0.0399,1185,0.374,"regorafenib, sorafenib",1.39902710431325,0.42712839779952,FALSE +"H358","Pearson.est","retinoid receptor agonist",-0.43514,-1.04,0.435,930,0.768,"tamibarotene, CD.437, bexarotene, adarotene",0.361510743045363,0.114638779968488,FALSE +"H358","Pearson.est","ribonucleotide reductase inhibitor",-0.39792,-0.958,0.525,733,0.832,"fludarabine.phosphate, LY2334737, clofarabine, cladribine, fludarabine",0.279840696594043,0.0798766737092761,FALSE +"H358","Pearson.est","serotonin receptor agonist",-0.46299,-1.11,0.334,1171,0.707,"zolmitriptan, aripiprazole",0.476253533188435,0.150580586203101,FALSE +"H358","Pearson.est","serotonin receptor antagonist",-0.52445,-1.25,0.193,954,0.573,"SB.200646, paliperidone, lurasidone, RS.16566, SB.216641, SB.228357, sertindole, aripiprazole",0.714442690992226,0.24184537803261,FALSE +"H358","Pearson.est","sodium channel blocker",-0.41859,-1,0.465,960,0.777,"quinidine, triamterene, brivaracetam, benzethonium, A.803467, lappaconite, ajmaline",0.332547047110046,0.109578981199086,FALSE +"H358","Pearson.est","src inhibitor",-0.25045,-0.601,0.924,1017,0.994,"ZM.306416, KX2.391, bosutinib",0.0343280287798933,0.00261361560268669,FALSE +"H358","Pearson.est","sterol demethylase inhibitor",0.3516,1.09,0.341,941,0.625,"lanoconazole, terconazole, ketoconazole, posaconazole, sulconazole, chlormidazole",0.467245621007502,0.204119982655925,FALSE +"H358","Pearson.est","TGF beta receptor inhibitor",-0.38895,-0.943,0.555,838,0.844,"SB.525334, SB.431542, D.4476",0.255707016877324,0.073657553374345,FALSE +"H358","Pearson.est","thymidylate synthase inhibitor",-0.65426,-1.55,0.0313,1234,0.321,"carmofur, trifluridine, raltitrexed",1.50445566245355,0.493494967595128,FALSE +"H358","Pearson.est","topoisomerase inhibitor",-0.35437,-0.833,0.707,684,0.884,"topotecan, valrubicin, amsacrine, beta.lapachone, camptothecin, rubitecan, etoposide, doxorubicin, irinotecan, licochalcone.a, SN.38, amonafide, TAS.103, voreloxin, idarubicin, genz.644282, exatecan.mesylate",0.150580586203101,0.0535477349869269,FALSE +"H358","Pearson.est","tubulin polymerization inhibitor",-0.48595,-1.15,0.281,734,0.679,"BNC105, dolastatin.10, verubulin, oxibendazole, CYT.997, fenbendazole, vincristine, epothilone.b, podophyllotoxin, plinabulin, indibulin, vindesine, flubendazole, ABT.751, paclitaxel, combretastatin.A.4, KX2.391, docetaxel, vinorelbine, parbendazole, fosbretabulin, nocodazole, taltobulin, albendazole",0.55129368009492,0.168130225719498,FALSE +"H358","Pearson.est","tyrosine kinase inhibitor",-0.49583,-1.2,0.233,1130,0.62,"mubritinib, AV.412, bafetinib, regorafenib, CP.724714, aminopurvalanol.a, BMS.599626, tivantinib, tyrphostin.A9, sorafenib, NVP.TAE226",0.632644078973981,0.207608310501746,FALSE +"H358","Pearson.est","VEGFR inhibitor",-0.42448,-1.03,0.447,1114,0.75,"AEE788, BMS.690514, ENMD.2076, pazopanib, regorafenib, lucitanib, RAF265, golvatinib, XL.647, sorafenib, OSI.930",0.349692476868064,0.1249387366083,FALSE +"H358","Pearson.est","vitamin D receptor agonist",-0.63843,-1.52,0.0408,1122,0.343,"maxacalcitol, paricalcitol, ercalcitriol, doxercalciferol, tacalcitol",1.38933983691012,0.464705879957229,FALSE +"H1650","Pearson.est","EGFR inhibitor",0.27961,0.678,0.864,611,0.971,"CUDC.101, tucatinib, CP.724714, AST.1306, afatinib, WZ.4002, neratinib, BIBU.1361, osimertinib, GW.583340, WZ.3146, poziotinib, dacomitinib, ARRY.334543, AEE788, AZD8931, XL.647, dovitinib, BMS.690514, pelitinib, lapatinib",0.0634862575211067,0.0127807700919951,FALSE +"H1650","Pearson.est","Abl kinase inhibitor",-0.39089,-1.07,0.36,1151,0.582,"nilotinib, ZM.306416, metatinib, ponatinib, GZD824, dasatinib",0.443697499232713,0.235077015350112,FALSE +"H1650","Pearson.est","acetylcholine receptor agonist",0.26352,0.631,0.898,711,0.982,"pilocarpine, xanomeline, nefiracetam, oxiracetam",0.0467236633326956,0.00788851221305034,FALSE +"H1650","Pearson.est","acetylcholine receptor antagonist",0.3486,0.839,0.65,150,0.938,"diphemanil",0.187086643357144,0.0277971616209356,FALSE +"H1650","Pearson.est","adenosine receptor antagonist",0.39051,0.951,0.537,406,0.841,"CGS.15943, SCH.58261, MRS.1220",0.270025714300444,0.0752040042020878,FALSE +"H1650","Pearson.est","adrenergic receptor agonist",-0.25463,-0.685,0.854,1080,0.91,"epinephrine, terbutaline, isoxsuprine, methyldopa, oxymetazoline, xylazine",0.068542129310995,0.0409586076789064,FALSE +"H1650","Pearson.est","adrenergic receptor antagonist",0.38886,0.934,0.539,324,0.828,"oxprenolol, atipamezole, atenolol......, prazosin, RS.17053, dronedarone",0.268411234813261,0.0819696632151199,FALSE +"H1650","Pearson.est","AKT inhibitor",0.56994,1.34,0.147,160,0.525,"uprosertib, A.674563, GDC.0068, GSK2110183",0.832682665251824,0.279840696594043,FALSE +"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.26305,-0.71,0.776,378,0.915,"DMH1, CEP.37440, alectinib, NVP.TAE684, AZD3463, crizotinib, SB.505124, brigatinib, lorlatinib, AP26113, GW.788388",0.110138278741812,0.0385789059335517,FALSE +"H1650","Pearson.est","androgen receptor antagonist",-0.44844,-1.26,0.194,1034,0.452,"enzalutamide, cyproterone.acetate, bicalutamide, RU.58841",0.712198270069774,0.344861565188618,FALSE +"H1650","Pearson.est","antioxidant",-0.69187,-1.88,0.0139,1084,0.119,"chlorogenic.acid, mesna, rutin",1.8569851997459,0.924453038607469,TRUE +"H1650","Pearson.est","AP inhibitor",-0.68725,-1.93,0.0171,1234,0.12,"LCL.161, birinapant, idronoxil, GDC.0152",1.76700388960785,0.920818753952375,TRUE +"H1650","Pearson.est","ATPase inhibitor",-0.42249,-1.14,0.29,1337,0.507,"digitoxigenin, digitoxin, ouabain, k.strophanthidin",0.537602002101044,0.294992040666664,FALSE +"H1650","Pearson.est","Aurora kinase inhibitor",0.72764,1.77,0.0098,279,0.203,"SNS.314, ZM.447439, barasertib.HQPA, barasertib, CCT137690, AT.9283, alisertib, AMG900, PHA.680632, hesperadin, danusertib, MK.8745, PF.03814735, tozasertib, GSK1070916, TAK.901, aurora.a.inhibitor.i",2.00877392430751,0.692503962086787,TRUE +"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.43339,1.05,0.388,562,0.775,"azithromycin, valnemulin, azalomycin.b, tilmicosin, josamycin",0.411168274405793,0.11069829749369,FALSE +"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.38463,0.927,0.547,523,0.821,"nadifloxacin, norfloxacin, lomefloxacin, novobiocin",0.262012673666569,0.0856568428805592,FALSE +"H1650","Pearson.est","BCL inhibitor",0.50328,1.25,0.208,294,0.554,"gossypol, TW.37, oridonin, ABT.737",0.681936665037238,0.25649023527157,FALSE +"H1650","Pearson.est","Bcr.Abl kinase inhibitor",-0.40312,-1.14,0.294,1151,0.507,"nilotinib, metatinib, ponatinib, GZD824, dasatinib",0.531652669587843,0.294992040666664,FALSE +"H1650","Pearson.est","benzodiazepine receptor agonist",0.257,0.612,0.911,412,0.963,"piperazine, ivermectin, zaleplon, ZK.93423",0.0404816230270017,0.0163737128754655,FALSE +"H1650","Pearson.est","bromodomain inhibitor",0.98544,2.39,0,27,0,"I.BET151, OTX015, JQ1...., I.BET.762, PFI.1, bromosporine",Inf,Inf,TRUE +"H1650","Pearson.est","calcium channel blocker",0.43501,1.04,0.43,686,0.773,"carboxyamidotriazole, SR.33805, fendiline, pranidipine, mibefradil, penfluridol, cinnarazine, tetrandrine, SKF.96365",0.366531544420413,0.111820506081675,FALSE +"H1650","Pearson.est","CC chemokine receptor antagonist",0.60799,1.48,0.0739,123,0.422,"PF.04136309, SB.225002, ZK811752",1.13135556160517,0.374687549038326,FALSE +"H1650","Pearson.est","CDK inhibitor",0.62282,1.5,0.0705,192,0.471,"indisulam, TG.02, JNJ.7706621, palbociclib, ribociclib, BMS.265246, BMS.387032, abemaciclib, R547, arcyriaflavin.a, AZD5438",1.1518108830086,0.326979092871104,FALSE +"H1650","Pearson.est","CHK inhibitor",-0.55109,-1.54,0.0623,1254,0.218,"AZD7762, LY2606368, SCH.900776",1.20551195334083,0.661543506395395,FALSE +"H1650","Pearson.est","cyclooxygenase inhibitor",0.24702,0.587,0.919,427,0.966,"naproxen, FR.122047, piroxicam, curcumin, tepoxalin, aspirin, ramifenazone, phenazone",0.0366844886138887,0.0150228735845067,FALSE +"H1650","Pearson.est","cytochrome P450 inhibitor",-0.66477,-1.77,0.0213,1271,0.153,"clotrimazole, metyrapone, eplerenone, itraconazole",1.67162039656126,0.815308569182401,TRUE +"H1650","Pearson.est","DNA alkylating agent",0.47236,1.13,0.302,184,0.767,"melphalan, mitomycin.c, TH.302, satraplatin",0.519993057042849,0.115204636051019,FALSE +"H1650","Pearson.est","DNA inhibitor",0.38923,0.922,0.546,326,0.81,"melphalan, chlorambucil, oxaliplatin, mechlorethamine, pibenzimol, primaquine",0.262807357295263,0.0915149811213502,FALSE +"H1650","Pearson.est","DNA methyltransferase inhibitor",0.68094,1.64,0.0331,260,0.398,"fdcyd, azacitidine, SGI.1027",1.48017200622428,0.400116927926312,FALSE +"H1650","Pearson.est","DNA polymerase inhibitor",0.23963,0.579,0.945,565,0.954,"trifluridine, cephalomannine, idoxuridine, adefovir.dipivoxil",0.0245681914907371,0.0204516252959049,FALSE +"H1650","Pearson.est","DNA synthesis inhibitor",0.33975,0.804,0.721,290,0.914,"mitomycin.c, anisomycin, floxuridine, cyclocytidine",0.142064735280571,0.0390538042661686,FALSE +"H1650","Pearson.est","dopamine receptor antagonist",0.31405,0.748,0.771,88,0.957,"sertindole, lurasidone",0.112945621949043,0.0190880622231565,FALSE +"H1650","Pearson.est","estrogen receptor agonist",-0.32153,-0.895,0.564,463,0.733,"levonorgestrel, estradiol, erteberel, equol, PPT, estrone, ethinyl.estradiol, estradiol.cypionate",0.248720896016658,0.134896025358872,FALSE +"H1650","Pearson.est","estrogen receptor antagonist",0.28199,0.679,0.843,484,0.989,"clomifene, fulvestrant, toremifene",0.0741724253752577,0.0048037084028206,FALSE +"H1650","Pearson.est","FGFR inhibitor",-0.36651,-1,0.405,1114,0.62,"lenvatinib, orantinib, erdafitinib, MK.2461, AZD4547",0.392544976785331,0.207608310501746,FALSE +"H1650","Pearson.est","FLT3 inhibitor",0.52796,1.27,0.192,264,0.564,"TG.101348, TG.02, sorafenib, pacritinib, tozasertib, quizartinib",0.71669877129645,0.248720896016658,FALSE +"H1650","Pearson.est","glucocorticoid receptor agonist",0.26196,0.619,0.895,459,0.974,"deflazacort, betamethasone, rimexolone, methylprednisolone, halobetasol.propionate, fludroxycortide, prednisolone, clobetasol.propionate",0.048176964684088,0.0114410431213845,FALSE +"H1650","Pearson.est","glutamate receptor antagonist",-0.62348,-1.73,0.0348,1222,0.157,"CPP, tiletamine, MTPG, kynurenic.acid, latrepirdine, SIB.1757, JNJ.16259685",1.45842075605342,0.804100347590766,TRUE +"H1650","Pearson.est","glycogen synthase kinase inhibitor",-0.54584,-1.54,0.0833,1226,0.218,"indirubin, tideglusib, CHIR.98014, TWS.119",1.07935499859321,0.661543506395395,FALSE +"H1650","Pearson.est","growth factor receptor inhibitor",0.48895,1.18,0.269,706,0.683,"danusertib, GW.441756, GSK1838705A, GSK1904529A, lestaurtinib, AZD3463",0.570247719997592,0.165579296318467,FALSE +"H1650","Pearson.est","HCV inhibitor",-0.28532,-0.796,0.691,1273,0.866,"daclatasvir, narlaprevir",0.160521952625802,0.0624821079826534,FALSE +"H1650","Pearson.est","HDAC inhibitor",0.62824,1.54,0.0542,236,0.496,"R306465, RGFP966, resminostat, M.344, chidamide, scriptaid, vorinostat, givinostat, belinostat, SB.939, nexturastat.a, AR.42, tacedinaline, PCI.24781",1.26600071346161,0.304518323509803,FALSE +"H1650","Pearson.est","histamine receptor antagonist",0.27764,0.665,0.88,300,0.966,"cyproheptadine, epinastine, terfenadine, pheniramine, nizatidine",0.0555173278498314,0.0150228735845067,FALSE +"H1650","Pearson.est","HMGCR inhibitor",-0.80547,-2.19,0,1350,0.0514,"atorvastatin, lovastatin, fluvastatin, pitavastatin",Inf,1.28903688100472,TRUE +"H1650","Pearson.est","HSP inhibitor",0.29315,0.715,0.817,544,0.983,"tanespimycin, NMS.E973, XL888, PU.H71, SNX.5422",0.0877779434675845,0.00744648216786438,FALSE +"H1650","Pearson.est","JAK inhibitor",0.5452,1.31,0.167,238,0.53,"TG.101348, TG.02, AT.9283, pacritinib, LY2784544, tozasertib",0.777283528852417,0.275724130399211,FALSE +"H1650","Pearson.est","KIT inhibitor",0.33746,0.813,0.687,507,0.919,"sorafenib, regorafenib, pazopanib, OSI.930, masitinib, vatalanib, motesanib, KI.8751",0.16304326294045,0.0366844886138887,FALSE +"H1650","Pearson.est","MDM inhibitor",0.40484,0.976,0.481,165,0.836,"serdemetan, RITA",0.317854923626168,0.0777937225609836,FALSE +"H1650","Pearson.est","MEK inhibitor",-0.27447,-0.745,0.749,995,0.906,"MEK162, Ro.4987655, U.0126, selumetinib, MEK1.2.inhibitor, AZD8330, PD.318088, cobimetinib, refametinib, PD.184352, TAK.733",0.125518182300534,0.0428718023231869,FALSE +"H1650","Pearson.est","MET inhibitor",-0.64127,-1.7,0.0488,1263,0.152,"NVP.BVU972, LY2801653, PF.04217903",1.31158017799729,0.818156412055227,TRUE +"H1650","Pearson.est","microtubule inhibitor",0.41602,1.03,0.43,255,0.77,"D.64131, vinflunine, cabazitaxel",0.366531544420413,0.113509274827518,FALSE +"H1650","Pearson.est","mTOR inhibitor",-0.20555,-0.576,0.964,1187,0.942,"NVP.BEZ235, deforolimus, LY3023414, SB.2343, MLN0128, torin.1, sirolimus, OSI.027",0.0159229660971692,0.0259490972071227,FALSE +"H1650","Pearson.est","NFkB pathway inhibitor",0.59455,1.44,0.0741,441,0.475,"EVP4593, betulinic.acid, parthenolide...., curcumin, tyloxapol, BAY.11.7085",1.13018179202067,0.323306390375133,FALSE +"H1650","Pearson.est","opioid receptor agonist",-0.72419,-1.97,0.0128,1248,0.144,"spiradoline, ADL5859, cebranopadol, BW.180C",1.89279003035213,0.84163750790475,TRUE +"H1650","Pearson.est","p38 MAPK inhibitor",0.46085,1.12,0.305,683,0.759,"talmapimod, SB.239063, SB.242235, skepinone.l, CMPD.1, VX.702",0.515700160653214,0.11975822410452,FALSE +"H1650","Pearson.est","PARP inhibitor",0.57063,1.37,0.116,269,0.49,"niraparib, olaparib, talazoparib, PJ.34",0.935542010773082,0.309803919971486,FALSE +"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.23988,0.578,0.933,142,0.938,"sorafenib, regorafenib, pazopanib",0.0301183562535,0.0277971616209356,FALSE +"H1650","Pearson.est","phosphatase inhibitor",-0.43329,-1.15,0.269,1362,0.573,"menadione, bis.maltolato.oxovanadium.IV., BVT.948",0.570247719997592,0.24184537803261,FALSE +"H1650","Pearson.est","phosphodiesterase inhibitor",-0.34379,-0.929,0.459,1369,0.707,"anagrelide, GSK256066",0.338187314462739,0.150580586203101,FALSE +"H1650","Pearson.est","PI3K inhibitor",0.38715,0.936,0.529,259,0.847,"CUDC.907, taselisib, alpelisib, YM.201636, LY303511, PIK.75, CH5132799",0.276544327964814,0.0721165896692931,FALSE +"H1650","Pearson.est","PLK inhibitor",0.73954,1.77,0.00978,219,0.203,"GW.843682X, volasertib, BI.2536, NMS.1286937, HMN.214",2.0096611452124,0.692503962086787,TRUE +"H1650","Pearson.est","potassium channel blocker",0.34578,0.825,0.673,144,0.919,"oleoylethanolamide",0.171984935776023,0.0366844886138887,FALSE +"H1650","Pearson.est","PPAR receptor agonist",0.3471,0.834,0.659,640,0.925,"oleoylethanolamide, GW.501516, ciprofibrate, S26948, pterostilbene",0.18111458540599,0.0338582672609674,FALSE +"H1650","Pearson.est","progesterone receptor agonist",-0.25154,-0.675,0.865,1194,0.884,"norethindrone, norethindrone.acetate, danazol",0.0629838925351858,0.0535477349869269,FALSE +"H1650","Pearson.est","proteasome inhibitor",0.53184,1.28,0.174,632,0.57,"delanzomib, ONX.0914, MG.132, oprozomib, carfilzomib",0.7594507517174,0.244125144327509,FALSE +"H1650","Pearson.est","protein synthesis inhibitor",0.39482,0.959,0.518,63,0.848,"azomycin..2.nitroimidazole., anguidine, bruceantin",0.285670240254767,0.0716041477432862,FALSE +"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.43859,1.06,0.373,477,0.808,"CP.724714, NVP.TAE226, tyrphostin.A9, mubritinib",0.428291168191312,0.0925886392254138,FALSE +"H1650","Pearson.est","RAF inhibitor",0.44588,1.08,0.371,256,0.821,"sorafenib, GDC.0879, regorafenib, TAK.632, PLX.4720",0.430626090384954,0.0856568428805592,FALSE +"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.63418,1.51,0.0499,336,0.505,"sorafenib, regorafenib, cabozantinib",1.30189945437661,0.296708621881339,FALSE +"H1650","Pearson.est","retinoid receptor agonist",0.65859,1.58,0.0292,403,0.465,"adarotene, bexarotene, fenretinide, CD.437, tamibarotene, adapalene",1.53461714855158,0.332547047110046,FALSE +"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.41741,1.02,0.437,478,0.768,"pentostatin, LY2334737, fludarabine, clofarabine, gemcitabine",0.359518563029578,0.114638779968488,FALSE +"H1650","Pearson.est","serotonin receptor agonist",0.43179,1.05,0.404,21,0.775,"aripiprazole",0.393618634889395,0.11069829749369,FALSE +"H1650","Pearson.est","serotonin receptor antagonist",0.58268,1.4,0.134,159,0.492,"sertindole, aripiprazole, lurasidone, SB.228357",0.872895201635192,0.30803489723264,FALSE +"H1650","Pearson.est","sodium channel blocker",0.52017,1.26,0.191,355,0.558,"benzethonium, ajmaline, butamben, quinidine, triamterene, brivaracetam",0.718966632752272,0.253365801062421,FALSE +"H1650","Pearson.est","src inhibitor",-0.38689,-1.02,0.384,1141,0.625,"PP.1, saracatinib, ZM.306416, dasatinib",0.415668775632469,0.204119982655925,FALSE +"H1650","Pearson.est","sterol demethylase inhibitor",-0.52606,-1.46,0.0934,1174,0.26,"ketoconazole, sulconazole, terconazole, lanoconazole",1.02965312376991,0.585026652029182,FALSE +"H1650","Pearson.est","TGF beta receptor inhibitor",0.33234,0.798,0.715,126,0.904,"D.4476",0.145693958198919,0.0438315695246367,FALSE +"H1650","Pearson.est","thymidylate synthase inhibitor",0.62777,1.49,0.058,274,0.443,"raltitrexed, trifluridine, doxifluridine",1.23657200643706,0.35359627377693,FALSE +"H1650","Pearson.est","topoisomerase inhibitor",0.5865,1.41,0.0991,453,0.51,"exatecan.mesylate, genz.644282, topotecan, irinotecan, idarubicin, rubitecan, TAS.103, dexrazoxane, etoposide.phosphate, amsacrine, epirubicin, etoposide, teniposide, daunorubicin, SN.38, doxorubicin, camptothecin, voreloxin, licochalcone.a",1.00392634551472,0.292429823902064,FALSE +"H1650","Pearson.est","tubulin polymerization inhibitor",0.56282,1.37,0.127,566,0.49,"taltobulin, parbendazole, albendazole, combretastatin.A.4, vinorelbine, indibulin, verubulin, vincristine, KX2.391, fosbretabulin, ABT.751, oxibendazole, nocodazole, podophyllotoxin, CYT.997, paclitaxel, dolastatin.10, epothilone.b, epothilone.d, flubendazole, fenbendazole, docetaxel",0.896196279044043,0.309803919971486,FALSE +"H1650","Pearson.est","tyrosine kinase inhibitor",0.44214,1.06,0.382,370,0.808,"sorafenib, regorafenib, CP.724714, NVP.TAE226, tivantinib, UNC2250, hypericin, bafetinib, cabozantinib, tyrphostin.A9, aminopurvalanol.a",0.417936637088291,0.0925886392254138,FALSE +"H1650","Pearson.est","VEGFR inhibitor",0.29375,0.704,0.835,608,0.977,"sorafenib, regorafenib, golvatinib, pazopanib, foretinib, OSI.930, cabozantinib, vatalanib, motesanib, KI.8751, axitinib, AEE788, XL.647, dovitinib, BMS.690514, RAF265, cediranib",0.0783135245163979,0.0101054362812269,FALSE +"H1650","Pearson.est","vitamin D receptor agonist",0.54476,1.31,0.177,663,0.53,"tacalcitol, maxacalcitol, ercalcitriol, doxercalciferol, alfacalcidol, calcitriol, paricalcitol",0.752026733638193,0.275724130399211,FALSE +"HCC95","Pearson.est","EGFR inhibitor",0.18629,0.466,0.985,331,1,"tucatinib, CUDC.101, dovitinib, BMS.690514, AST.1306, poziotinib, CGP.52411, WZ.3146, CP.724714, afatinib",0.00656376950238827,0,FALSE +"HCC95","Pearson.est","Abl kinase inhibitor",-0.50791,-1.32,0.175,1084,0.626,"KW.2449, bosutinib, ZM.306416, tozasertib, imatinib, ponatinib, dasatinib",0.756961951313706,0.20342566678957,FALSE +"HCC95","Pearson.est","acetylcholine receptor agonist",0.29369,0.736,0.785,369,0.982,"xanomeline, pilocarpine, oxiracetam",0.105130343254747,0.00788851221305034,FALSE +"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.27043,-0.698,0.828,1355,0.992,"dicycloverine",0.0819696632151199,0.00348832784582135,FALSE +"HCC95","Pearson.est","adenosine receptor antagonist",-0.33171,-0.849,0.61,478,0.921,"PSB.1115, CGS.15943, MRS.1220, theophylline, sulmazole, SCH.58261, istradefylline",0.214670164989233,0.0357403698031511,FALSE +"HCC95","Pearson.est","adrenergic receptor agonist",-0.41998,-1.08,0.362,1225,0.743,"norepinephrine, A61603, epinephrine, terbutaline, isoxsuprine",0.441291429466834,0.129011186239425,FALSE +"HCC95","Pearson.est","adrenergic receptor antagonist",0.54287,1.35,0.158,293,0.815,"prazosin, practolol, RS.17053, dronedarone, atenolol......, propranolol, vincamine, naftidrofuryl",0.801342913045577,0.0888423912600234,FALSE +"HCC95","Pearson.est","AKT inhibitor",0.36819,0.923,0.54,74,1,"GSK2110183, GDC.0068",0.267606240177031,0,FALSE +"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.3529,-0.92,0.527,1063,0.847,"DMH1, AZD3463, crizotinib, CEP.37440, GW.788388, AP26113",0.278189384787453,0.0721165896692931,FALSE +"HCC95","Pearson.est","androgen receptor antagonist",-0.41834,-1.08,0.357,1068,0.743,"cyproterone.acetate, bicalutamide, RU.58841",0.447331783887807,0.129011186239425,FALSE +"HCC95","Pearson.est","antioxidant",-0.60916,-1.52,0.0795,940,0.648,"benfotiamine, chlorogenic.acid, rutin, taurine, trolox",1.09963287134353,0.188424994129407,FALSE +"HCC95","Pearson.est","AP inhibitor",-0.54262,-1.38,0.125,987,0.56,"embelin, birinapant, idronoxil, GDC.0152, LCL.161",0.903089986991944,0.2518119729938,FALSE +"HCC95","Pearson.est","ATPase inhibitor",-0.41978,-1.08,0.34,1349,0.743,"digitoxigenin, k.strophanthidin, digitoxin",0.468521082957745,0.129011186239425,FALSE +"HCC95","Pearson.est","Aurora kinase inhibitor",0.53293,1.31,0.163,125,0.834,"PHA.680632, alisertib, TAK.901, AT.9283, barasertib.HQPA, aurora.a.inhibitor.i, SNS.314, danusertib",0.787812395596042,0.0788339493622613,FALSE +"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.26684,-0.696,0.808,1059,0.966,"azithromycin, azalomycin.b, dirithromycin",0.0925886392254138,0.0150228735845067,FALSE +"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.36354,0.924,0.526,564,1,"norfloxacin, novobiocin, finafloxacin, sparfloxacin, sarafloxacin",0.279014255846261,0,FALSE +"HCC95","Pearson.est","BCL inhibitor",-0.26345,-0.671,0.837,1163,0.944,"gossypol, obatoclax, HA14.1",0.07727454200674,0.025028005701931,FALSE +"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.49935,-1.24,0.232,1139,0.68,"bosutinib, tozasertib, imatinib, ponatinib, dasatinib",0.6345120151091,0.167491087293764,FALSE +"HCC95","Pearson.est","benzodiazepine receptor agonist",0.39765,1.01,0.432,404,0.979,"ZK.93423, gamma.aminobutyric.acid, CL.218872, bentazepam, zaleplon, indiplon",0.364516253185088,0.00921730819686218,FALSE +"HCC95","Pearson.est","bromodomain inhibitor",0.80551,2.05,0,150,0.0514,"I.BET151, OTX015, I.BET.762, JQ1....",Inf,1.28903688100472,TRUE +"HCC95","Pearson.est","calcium channel blocker",0.5954,1.47,0.108,441,0.677,"cinnarazine, fendiline, efonidipine.monoethanolate, pranidipine, SR.33805, carboxyamidotriazole",0.96657624451305,0.169411331314856,FALSE +"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.36689,-0.942,0.501,1445,0.875,"navarixin",0.300162274132754,0.0579919469776868,FALSE +"HCC95","Pearson.est","CDK inhibitor",0.39878,0.998,0.447,287,0.959,"R547, BMS.387032, CR8..R., ribociclib, PHA.793887, arcyriaflavin.a, indisulam, JNJ.7706621",0.349692476868064,0.0181813928293364,FALSE +"HCC95","Pearson.est","CHK inhibitor",-0.8099,-2.13,0,1282,0.0212,"AZD7762, LY2603618, LY2606368, SCH.900776",Inf,1.67366413907125,TRUE +"HCC95","Pearson.est","cyclooxygenase inhibitor",0.31232,0.766,0.723,238,0.962,"naproxen, FR.122047, aspirin, piroxicam",0.140861702705469,0.0168249279621871,FALSE +"HCC95","Pearson.est","cytochrome P450 inhibitor",-0.48569,-1.22,0.234,979,0.625,"metyrapone, itraconazole, PF.4981517, eplerenone, clotrimazole",0.630784142589857,0.204119982655925,FALSE +"HCC95","Pearson.est","DNA alkylating agent",-0.20611,-0.526,0.967,1050,0.968,"estramustine, carboplatin, carmustine, streptozotocin",0.0145735259169983,0.0141246426916063,FALSE +"HCC95","Pearson.est","DNA inhibitor",0.27738,0.699,0.832,149,0.952,"busulfan, tirapazamine, oxaliplatin",0.0798766737092761,0.0213630516155257,FALSE +"HCC95","Pearson.est","DNA methyltransferase inhibitor",0.42579,1.06,0.373,9,0.905,"SGI.1027",0.428291168191312,0.0433514207947967,FALSE +"HCC95","Pearson.est","DNA polymerase inhibitor",0.42679,1.06,0.393,208,0.905,"trifluridine, cephalomannine, cidofovir",0.405607449624573,0.0433514207947967,FALSE +"HCC95","Pearson.est","DNA synthesis inhibitor",-0.26535,-0.674,0.83,1436,0.968,"altretamine",0.0809219076239261,0.0141246426916063,FALSE +"HCC95","Pearson.est","dopamine receptor antagonist",0.34623,0.892,0.584,235,1,"sertindole, isofloxythepin, domperidone, clebopride, lurasidone",0.233587152887601,0,FALSE +"HCC95","Pearson.est","estrogen receptor agonist",-0.38852,-1.01,0.425,1106,0.81,"estrone, PPT, estradiol",0.371611069949688,0.0915149811213502,FALSE +"HCC95","Pearson.est","estrogen receptor antagonist",0.51276,1.29,0.189,167,0.803,"clomifene, tamoxifen",0.723538195826756,0.095284454721319,FALSE +"HCC95","Pearson.est","FGFR inhibitor",-0.49314,-1.28,0.168,1121,0.652,"erdafitinib, MK.2461, lucitanib, nintedanib, AZD4547",0.774690718274137,0.18575240426808,FALSE +"HCC95","Pearson.est","FLT3 inhibitor",0.24037,0.597,0.911,55,0.968,"TG.101348, dovitinib",0.0404816230270017,0.0141246426916063,FALSE +"HCC95","Pearson.est","glucocorticoid receptor agonist",0.58325,1.48,0.0948,377,0.782,"hydrocortisone, prednisolone, rimexolone, methylprednisolone, betamethasone, halcinonide, clobetasol.propionate, flumethasone.pivalate, dexamethasone.acetate, deflazacort, desonide, ciclesonide, difluprednate, halobetasol.propionate",1.02319166266193,0.106793246940152,FALSE +"HCC95","Pearson.est","glutamate receptor antagonist",0.34743,0.879,0.587,256,1,"ACDPP, felbamate, latrepirdine, IEM1754, CPP",0.231361898752386,0,FALSE +"HCC95","Pearson.est","glycogen synthase kinase inhibitor",-0.54739,-1.41,0.143,1135,0.56,"LY2090314, tideglusib, AZD2858, indirubin",0.844663962534938,0.2518119729938,FALSE +"HCC95","Pearson.est","growth factor receptor inhibitor",-0.24518,-0.613,0.915,1116,0.957,"AZD3463, PHA.848125, GSK1838705A",0.0385789059335517,0.0190880622231565,FALSE +"HCC95","Pearson.est","HCV inhibitor",-0.426,-1.1,0.347,1303,0.834,"narlaprevir, Ro.9187",0.459670525209126,0.0788339493622613,FALSE +"HCC95","Pearson.est","HDAC inhibitor",-0.38802,-0.998,0.431,1181,0.796,"tacedinaline, JNJ.26481585, panobinostat, trichostatin.a, mocetinostat, entinostat, PCI.24781, RG2833, dacinostat",0.365522729839268,0.0990869322623309,FALSE +"HCC95","Pearson.est","histamine receptor antagonist",0.27106,0.673,0.867,180,0.937,"chloropyramine, epinastine, levocetirizine, ICI.162846",0.0619809025237897,0.0282604091122217,FALSE +"HCC95","Pearson.est","HMGCR inhibitor",-0.56952,-1.47,0.0857,1154,0.677,"lovastatin, fluvastatin, pitavastatin",1.0670191780768,0.169411331314856,FALSE +"HCC95","Pearson.est","HSP inhibitor",-0.30681,-0.772,0.723,1405,0.932,"NVP.AUY922, ganetespib",0.140861702705469,0.0305840876460186,FALSE +"HCC95","Pearson.est","JAK inhibitor",0.2812,0.685,0.817,93,0.946,"TG.101348, AT.9283",0.0877779434675845,0.0241088635982073,FALSE +"HCC95","Pearson.est","KIT inhibitor",-0.25003,-0.641,0.896,1392,0.955,"dasatinib, telatinib",0.0476919903378748,0.0199966284162537,FALSE +"HCC95","Pearson.est","MDM inhibitor",0.77867,2,0.0038,161,0.049,"nutlin.3, idasanutlin, CGM097, AMG.232",2.42021640338319,1.30980391997149,TRUE +"HCC95","Pearson.est","MEK inhibitor",-0.3617,-0.908,0.544,1166,0.839,"MEK162, BIX.02188, cobimetinib, TAK.733, PD.184352, nobiletin",0.26440110030182,0.0762380391712997,FALSE +"HCC95","Pearson.est","MET inhibitor",-0.84035,-2.2,0,1380,0.0155,"PF.04217903, NVP.BVU972, PHA.665752, LY2801653",Inf,1.80966830182971,TRUE +"HCC95","Pearson.est","microtubule inhibitor",0.28408,0.71,0.798,495,0.991,"triclabendazole, colchicine, D.64131, cytochalasin.b, cabazitaxel",0.0979971086492706,0.00392634551472468,FALSE +"HCC95","Pearson.est","mTOR inhibitor",0.15504,0.388,1,435,0.999,"PF.05212384, PI.103, WYE.125132, PKI.179, PP242, AZD8055, everolimus, voxtalisib",0,0.000434511774017692,FALSE +"HCC95","Pearson.est","NFkB pathway inhibitor",0.30705,0.789,0.723,141,1,"EVP4593, IKK.2.inhibitor.V",0.140861702705469,0,FALSE +"HCC95","Pearson.est","opioid receptor agonist",-0.55585,-1.42,0.121,1067,0.695,"cebranopadol, trimebutine, BW.180C, ADL5859",0.91721462968355,0.158015195409886,FALSE +"HCC95","Pearson.est","p38 MAPK inhibitor",0.5991,1.53,0.0812,291,0.768,"SB.239063, CMPD.1, SB.242235",1.09044397075882,0.114638779968488,FALSE +"HCC95","Pearson.est","PARP inhibitor",0.41993,1.06,0.394,272,0.905,"AG.14361, niraparib, PJ.34",0.404503778174426,0.0433514207947967,FALSE +"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.36313,-0.932,0.539,1217,0.859,"imatinib, CP.673451, ponatinib, nintedanib, dasatinib, telatinib",0.268411234813261,0.0660068361687577,FALSE +"HCC95","Pearson.est","phosphatase inhibitor",-0.41223,-1.04,0.401,1400,0.786,"bis.maltolato.oxovanadium.IV., BVT.948",0.396855627379818,0.104577453960592,FALSE +"HCC95","Pearson.est","phosphodiesterase inhibitor",-0.60652,-1.55,0.0679,1428,0.715,"GSK256066, YM.976",1.1681302257195,0.145693958198919,FALSE +"HCC95","Pearson.est","PI3K inhibitor",0.27659,0.708,0.822,359,0.966,"AZD6482, PF.05212384, PI.103, PIK.75, taselisib, PI.828, buparlisib, PKI.179, CUDC.907",0.0851281824599496,0.0150228735845067,FALSE +"HCC95","Pearson.est","PLK inhibitor",0.44802,1.13,0.33,80,0.893,"HMN.214, GW.843682X",0.481486060122112,0.0491485411114536,FALSE +"HCC95","Pearson.est","potassium channel blocker",-0.62441,-1.56,0.0658,1415,0.917,"mepivacaine",1.18177410638604,0.0376306643299789,FALSE +"HCC95","Pearson.est","PPAR receptor agonist",0.34245,0.871,0.602,510,0.957,"GW.501516, ciprofibrate, pterostilbene, S26948",0.220403508742175,0.0190880622231565,FALSE +"HCC95","Pearson.est","progesterone receptor agonist",-0.31095,-0.794,0.697,1038,0.958,"nomegestrol.acetate, dienogest, danazol, norethindrone.acetate",0.156767221901991,0.0186344909214556,FALSE +"HCC95","Pearson.est","proteasome inhibitor",0.33787,0.847,0.654,296,0.936,"MG.132, delanzomib, ONX.0914",0.184422251675733,0.0287241512618947,FALSE +"HCC95","Pearson.est","protein synthesis inhibitor",0.34499,0.889,0.571,303,1,"azomycin..2.nitroimidazole., clofoctol, harringtonine, bruceantin, puromycin, florfenicol",0.243363891754152,0,FALSE +"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.31179,-0.788,0.671,1004,0.936,"NVP.TAE226, rheochrysidin, PP.121, AV.412, BMS.599626",0.173277479831008,0.0287241512618947,FALSE +"HCC95","Pearson.est","RAF inhibitor",0.31435,0.786,0.713,488,0.987,"PLX.4720, GDC.0879, dabrafenib, sorafenib, SB.590885",0.146910470148134,0.00568284733036327,FALSE +"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.32668,-0.842,0.594,1378,0.9,"vandetanib",0.226213555018806,0.0457574905606751,FALSE +"HCC95","Pearson.est","retinoid receptor agonist",0.45884,1.16,0.283,349,0.941,"bexarotene, adarotene, adapalene, CD.437",0.54821356447571,0.0264103765727431,FALSE +"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.30625,0.768,0.751,19,0.988,"cytarabine",0.124360062995832,0.00524305541237188,FALSE +"HCC95","Pearson.est","serotonin receptor agonist",-0.48333,-1.23,0.229,1127,0.649,"zolmitriptan, NAN.190",0.640164517660112,0.187755303199631,FALSE +"HCC95","Pearson.est","serotonin receptor antagonist",0.48537,1.22,0.211,235,0.85,"sertindole, SB.228357, lurasidone",0.675717544702307,0.0705810742857073,FALSE +"HCC95","Pearson.est","sodium channel blocker",0.5049,1.27,0.187,319,0.782,"benzethonium, brivaracetam, benzocaine, oxcarbazepine, ajmaline, A.803467, cibenzoline",0.728158393463501,0.106793246940152,FALSE +"HCC95","Pearson.est","src inhibitor",-0.54015,-1.41,0.112,1102,0.56,"PP.2, bosutinib, ZM.306416, dasatinib, PP.1",0.950781977329818,0.2518119729938,FALSE +"HCC95","Pearson.est","sterol demethylase inhibitor",0.57416,1.43,0.108,181,0.69,"chlormidazole, posaconazole, sulconazole",0.96657624451305,0.161150909262745,FALSE +"HCC95","Pearson.est","TGF beta receptor inhibitor",0.62892,1.59,0.0499,227,0.759,"SB.525334, D.4476",1.30189945437661,0.11975822410452,FALSE +"HCC95","Pearson.est","thymidylate synthase inhibitor",0.351,0.878,0.605,110,0.978,"trifluridine",0.218244625347531,0.00966114521239857,FALSE +"HCC95","Pearson.est","topoisomerase inhibitor",0.25725,0.651,0.863,395,0.938,"epirubicin, etoposide.phosphate, amonafide, idarubicin, teniposide, doxorubicin, voreloxin, dexrazoxane",0.0639892042847904,0.0277971616209356,FALSE +"HCC95","Pearson.est","tubulin polymerization inhibitor",0.45845,1.13,0.319,372,0.893,"oxibendazole, indibulin, vincristine, parbendazole, ABT.751, flubendazole, combretastatin.A.4, taltobulin, mebendazole, vinorelbine, epothilone.b, KX2.391, dolastatin.10",0.496209316942819,0.0491485411114536,FALSE +"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.23557,-0.587,0.916,1360,0.954,"AMG.208, vandetanib, dasatinib",0.0381045263321496,0.0204516252959049,FALSE +"HCC95","Pearson.est","VEGFR inhibitor",-0.30163,-0.761,0.741,1192,0.922,"ZM.306416, MK.2461, foretinib, lucitanib, ENMD.2076, nintedanib, vandetanib, semaxanib, telatinib",0.130181792020672,0.0352690789463706,FALSE +"HCC95","Pearson.est","vitamin D receptor agonist",0.33743,0.867,0.597,572,0.931,"calcitriol, paricalcitol, maxacalcitol, ercalcitriol, doxercalciferol",0.224025668870631,0.0310503190186574,FALSE +"H3255","Pearson.est","EGFR inhibitor",0.51456,1.28,0.167,526,0.49,"tucatinib, CUDC.101, AST.1306, lapatinib, CP.724714, ARRY.334543, WZ.4002, poziotinib, TAK.285, BMS.690514, AZD8931, BMS.599626, neratinib, canertinib, GW.583340, afatinib, osimertinib, BIBX.1382, PD.153035, dacomitinib, AEE788, CNX.2006, gefitinib, XL.647, OSI.420, rociletinib, dovitinib, BIBU.1361",0.777283528852417,0.309803919971486,FALSE +"H3255","Pearson.est","Abl kinase inhibitor",-0.27674,-0.779,0.728,1447,0.85,"dasatinib",0.137868620686963,0.0705810742857073,FALSE +"H3255","Pearson.est","acetylcholine receptor agonist",-0.32775,-0.912,0.537,1303,0.76,"tremorine, nicotine",0.270025714300444,0.119186407719209,FALSE +"H3255","Pearson.est","acetylcholine receptor antagonist",-0.55528,-1.59,0.0528,1204,0.283,"methscopolamine, iododexetimide, dicycloverine",1.27736607746619,0.54821356447571,FALSE +"H3255","Pearson.est","adenosine receptor antagonist",0.70801,1.75,0.00809,48,0.122,"CGS.15943, MRS.1220",2.09205147838773,0.913640169325252,TRUE +"H3255","Pearson.est","adrenergic receptor agonist",-0.4856,-1.38,0.134,1281,0.293,"xylazine, oxymetazoline, A61603, terbutaline, epinephrine",0.872895201635192,0.533132379645891,FALSE +"H3255","Pearson.est","adrenergic receptor antagonist",0.24748,0.605,0.926,88,0.954,"practolol, prazosin",0.0333890133180656,0.0204516252959049,FALSE +"H3255","Pearson.est","AKT inhibitor",0.63028,1.55,0.0408,351,0.287,"uprosertib, GDC.0068, GSK2110183, A.674563, triciribine, AZD5363, ONC201",1.38933983691012,0.542118103266008,FALSE +"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.32297,0.801,0.719,328,0.8,"SB.505124, crizotinib, AZD3463, DMH1",0.143271109617117,0.0969100130080564,FALSE +"H3255","Pearson.est","androgen receptor antagonist",-0.75073,-2.16,0.00386,1138,0.0519,"nilutamide, bicalutamide, flutamide, RU.58841, enzalutamide",2.41341269532824,1.28483264215154,TRUE +"H3255","Pearson.est","antioxidant",-0.4889,-1.37,0.156,705,0.261,"taurine, chlorogenic.acid, trolox, rutin, benfotiamine, mesna",0.806875401645538,0.583359492661719,FALSE +"H3255","Pearson.est","AP inhibitor",-0.48234,-1.37,0.165,1213,0.261,"LCL.161, birinapant, idronoxil, GDC.0152",0.782516055786094,0.583359492661719,FALSE +"H3255","Pearson.est","ATPase inhibitor",0.40255,0.972,0.509,263,0.735,"oligomycin.a, evodiamine, NMS.873, digoxin",0.293282217663241,0.133712660915805,FALSE +"H3255","Pearson.est","Aurora kinase inhibitor",0.65923,1.62,0.0231,402,0.267,"PHA.680632, AT.9283, aurora.a.inhibitor.i, CCT137690, TAK.901, SNS.314, barasertib.HQPA, AMG900, alisertib, barasertib, danusertib, CCT129202, ZM.447439, GSK1070916, hesperadin, MK.8745, PF.03814735, MK.5108",1.63638802010786,0.573488738635425,FALSE +"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.34772,0.859,0.628,158,0.78,"valnemulin, radezolid",0.202040356262804,0.10790539730952,FALSE +"H3255","Pearson.est","bacterial DNA gyrase inhibitor",-0.47972,-1.35,0.106,1365,0.26,"lomefloxacin, sparfloxacin",0.97469413473523,0.585026652029182,FALSE +"H3255","Pearson.est","BCL inhibitor",0.43439,1.07,0.39,569,0.671,"venetoclax, obatoclax, TW.37, ABT.737, gossypol",0.408935392973501,0.173277479831008,FALSE +"H3255","Pearson.est","Bcr.Abl kinase inhibitor",-0.32988,-0.929,0.511,1447,0.77,"dasatinib",0.291579099865287,0.113509274827518,FALSE +"H3255","Pearson.est","benzodiazepine receptor agonist",0.3559,0.863,0.639,437,0.792,"ZK.93423, ivermectin, zaleplon, piperazine",0.1944991418416,0.101274818410506,FALSE +"H3255","Pearson.est","bromodomain inhibitor",0.77046,1.89,0.00543,337,0.154,"I.BET151, JQ1...., OTX015, I.BET.762, bromosporine, PFI.1",2.26520017041115,0.812479279163537,TRUE +"H3255","Pearson.est","calcium channel blocker",0.51751,1.27,0.181,589,0.466,"carboxyamidotriazole, cinnarazine, SR.33805, penfluridol, mibefradil, pranidipine, fendiline",0.742321425130815,0.33161408331,FALSE +"H3255","Pearson.est","CC chemokine receptor antagonist",0.63266,1.54,0.05,101,0.274,"ZK811752, SB.225002",1.30102999566398,0.562249437179612,FALSE +"H3255","Pearson.est","CDK inhibitor",0.59661,1.44,0.0895,355,0.351,"arcyriaflavin.a, R547, indisulam, dinaciclib, BMS.387032, PHA.793887, TG.02, JNJ.7706621, kenpaullone, ribociclib, AT.7519, palbociclib, BMS.265246",1.04817696468409,0.454692883534176,FALSE +"H3255","Pearson.est","CHK inhibitor",-0.51695,-1.45,0.104,1240,0.281,"AZD7762, LY2606368, SCH.900776",0.98296666070122,0.55129368009492,FALSE +"H3255","Pearson.est","cyclooxygenase inhibitor",0.19921,0.492,0.981,645,0.997,"aspirin, tryptanthrin, ramifenazone, naproxen, FR.122047, phenazone, ketoprofen, pterostilbene, piroxicam, amfenac",0.0083309926200515,0.00130484168834428,FALSE +"H3255","Pearson.est","cytochrome P450 inhibitor",-0.75549,-2.11,0,1203,0.047,"metyrapone, morin, PF.4981517, clotrimazole, eplerenone, itraconazole",Inf,1.32790214206428,TRUE +"H3255","Pearson.est","DNA alkylating agent",0.33603,0.813,0.702,33,0.799,"TH.302, mitomycin.c",0.153662887870195,0.0974532206860086,FALSE +"H3255","Pearson.est","DNA inhibitor",0.31666,0.776,0.732,46,0.819,"primaquine, oxaliplatin",0.135488918941608,0.0867160982395816,FALSE +"H3255","Pearson.est","DNA methyltransferase inhibitor",0.72969,1.78,0.00938,201,0.116,"fdcyd, SGI.1027, azacitidine",2.02779716162094,0.935542010773082,TRUE +"H3255","Pearson.est","DNA polymerase inhibitor",0.4636,1.16,0.28,199,0.578,"trifluridine, idoxuridine, cephalomannine",0.552841968657781,0.238072161579471,FALSE +"H3255","Pearson.est","DNA synthesis inhibitor",0.44009,1.06,0.396,298,0.669,"mitomycin.c, cyclocytidine, anisomycin, floxuridine, artesunate, enocitabine",0.402304814074488,0.174573882232177,FALSE +"H3255","Pearson.est","dopamine receptor antagonist",0.29631,0.723,0.814,56,0.853,"sertindole, lurasidone",0.0893755951107988,0.069050968832477,FALSE +"H3255","Pearson.est","estrogen receptor agonist",-0.47711,-1.33,0.155,1131,0.259,"levonorgestrel, PPT, estradiol, estradiol.cypionate",0.809668301829709,0.586700235918748,FALSE +"H3255","Pearson.est","estrogen receptor antagonist",0.47823,1.15,0.285,176,0.578,"clomifene, fulvestrant",0.54515513999149,0.238072161579471,FALSE +"H3255","Pearson.est","FGFR inhibitor",-0.15446,-0.442,0.992,1375,0.995,"AZD4547",0.00348832784582135,0.00217691925427455,FALSE +"H3255","Pearson.est","FLT3 inhibitor",0.36379,0.894,0.585,601,0.777,"sorafenib, pacritinib, quizartinib, TG.02, GTP.14564, TG.101348, lestaurtinib, sunitinib, KW.2449, dovitinib, tozasertib, tandutinib",0.23284413391782,0.109578981199086,FALSE +"H3255","Pearson.est","glucocorticoid receptor agonist",-0.16725,-0.466,0.989,238,1,"rimexolone, methylprednisolone, deflazacort, prednisolone, betamethasone, halobetasol.propionate, clobetasol.propionate, fluticasone.propionate, prednisolone.hemisuccinate, flumethasone, triamcinolone.acetonide, halcinonide, beclomethasone.dipropionate, difluprednate, desonide, ciclesonide, flumethasone.pivalate, fluorometholone, triamcinolone, piretanide, fludroxycortide, hydrocortisone, dexamethasone.acetate, fluocinolone.acetonide, prednisolone.acetate",0.0048037084028206,0,FALSE +"H3255","Pearson.est","glutamate receptor antagonist",-0.28281,-0.794,0.703,1202,0.863,"CGP.37849, diazooxonorleucine, kynurenic.acid, SIB.1757, JNJ.16259685",0.153044674980176,0.0639892042847904,FALSE +"H3255","Pearson.est","glycogen synthase kinase inhibitor",-0.28728,-0.827,0.651,1109,0.843,"LY2090314, CHIR.99021, tideglusib, CHIR.98014",0.186419011431808,0.0741724253752577,FALSE +"H3255","Pearson.est","growth factor receptor inhibitor",0.65245,1.58,0.0344,366,0.3,"danusertib, GW.441756, AZD3463, lestaurtinib",1.46344155742847,0.522878745280338,FALSE +"H3255","Pearson.est","HCV inhibitor",0.50366,1.22,0.231,618,0.522,"PSI.7976, embelin, daclatasvir",0.636388020107856,0.282329496997738,FALSE +"H3255","Pearson.est","HDAC inhibitor",0.56122,1.4,0.0886,359,0.376,"M.344, scriptaid, givinostat, vorinostat, R306465, ACY.1215, AR.42, dacinostat, resminostat, RGFP966, trichostatin.a, PCI.24781, SB.939, romidepsin, belinostat",1.05256627811295,0.424812155072339,FALSE +"H3255","Pearson.est","histamine receptor antagonist",-0.17573,-0.492,0.968,621,1,"tiotidine, terfenadine, ICI.162846, tecastemizole, BF2.649, astemizole, nizatidine, cyproheptadine, cimetidine, pheniramine, ebastine, ranitidine, famotidine, zolantidine, chloropyramine, lafutidine",0.0141246426916063,0,FALSE +"H3255","Pearson.est","HMGCR inhibitor",-0.86477,-2.42,0,1247,0.0128,"simvastatin, lovastatin, atorvastatin, mevastatin, pitavastatin, fluvastatin",Inf,1.89279003035213,TRUE +"H3255","Pearson.est","HSP inhibitor",0.45141,1.11,0.344,674,0.634,"tanespimycin, XL888, NMS.E973, VER.49009, alvespimycin, KW.2478, NVP.AUY922, SNX.5422",0.46344155742847,0.197910742118267,FALSE +"H3255","Pearson.est","JAK inhibitor",0.36756,0.899,0.588,366,0.786,"AT.9283, pacritinib, TG.02, AZ960, TG.101348, lestaurtinib",0.230622673923862,0.104577453960592,FALSE +"H3255","Pearson.est","KIT inhibitor",0.37473,0.917,0.555,348,0.795,"sorafenib, pazopanib, regorafenib, OSI.930, vatalanib, imatinib, motesanib, masitinib",0.255707016877324,0.0996328713435297,FALSE +"H3255","Pearson.est","MDM inhibitor",0.5719,1.41,0.0951,583,0.381,"nutlin.3, RITA, CGM097, serdemetan, idasanutlin",1.02181948306259,0.419075024324381,FALSE +"H3255","Pearson.est","MEK inhibitor",0.15678,0.378,0.996,756,0.998,"arctigenin, PD.0325901, trametinib, U.0126, PD.198306, selumetinib, AZD8330, AS.703026",0.00174066157630127,0.000869458712628891,FALSE +"H3255","Pearson.est","MET inhibitor",-0.65234,-1.91,0.0266,1351,0.115,"LY2801653, PF.04217903, PHA.665752",1.57511836336893,0.939302159646388,TRUE +"H3255","Pearson.est","microtubule inhibitor",0.41436,1.04,0.42,410,0.686,"D.64131, vinflunine, podophyllotoxin, cabazitaxel, triclabendazole",0.3767507096021,0.163675884293248,FALSE +"H3255","Pearson.est","mTOR inhibitor",0.57528,1.39,0.127,380,0.371,"PF.05212384, WYE.125132, GSK2126458, PKI.179, AZD8055, AZD2014, MLN0128, everolimus, PI.103, sirolimus, GDC.0980, torin.2, XL388, PP242, torin.1, deforolimus, voxtalisib, NVP.BEZ235, temsirolimus",0.896196279044043,0.430626090384954,FALSE +"H3255","Pearson.est","NFkB pathway inhibitor",0.34847,0.844,0.657,1,0.786,"EVP4593",0.182434630440219,0.104577453960592,FALSE +"H3255","Pearson.est","opioid receptor agonist",-0.44346,-1.26,0.174,1436,0.304,"BW.180C",0.7594507517174,0.517126416391246,FALSE +"H3255","Pearson.est","p38 MAPK inhibitor",0.36204,0.882,0.61,221,0.778,"skepinone.l, SB.239063",0.214670164989233,0.109020403010311,FALSE +"H3255","Pearson.est","PARP inhibitor",0.4185,1.02,0.415,606,0.686,"niraparib, PJ.34, AG.14361, AZD2461, talazoparib",0.381951903287907,0.163675884293248,FALSE +"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.31204,0.761,0.758,363,0.823,"sorafenib, pazopanib, regorafenib, vatalanib, imatinib, trapidil, motesanib, masitinib, axitinib",0.120330794367946,0.0846001647877302,FALSE +"H3255","Pearson.est","phosphatase inhibitor",0.37289,0.91,0.577,399,0.787,"mycophenolate.mofetil, mycophenolic.acid, CID.5458317, GSK2830371, alexidine",0.238824186844269,0.104025267640935,FALSE +"H3255","Pearson.est","phosphodiesterase inhibitor",-0.52322,-1.48,0.0969,1038,0.314,"enoximone, papaverine, anagrelide, GSK256066, YM.976",1.01367622294923,0.503070351926785,FALSE +"H3255","Pearson.est","PI3K inhibitor",0.51742,1.27,0.19,500,0.466,"PF.05212384, GSK2126458, PKI.179, taselisib, CUDC.907, buparlisib, CH5132799, PI.103, GDC.0980, alpelisib, BGT226, PIK.75, voxtalisib, NVP.BEZ235, YM.201636, TG.100713, PI3K.IN.2, SB.2343, LY3023414",0.721246399047171,0.33161408331,FALSE +"H3255","Pearson.est","PLK inhibitor",0.75528,1.86,0.00266,229,0.104,"GW.843682X, NMS.1286937, HMN.214, volasertib, GSK461364, BI.2536",2.57511836336893,0.98296666070122,TRUE +"H3255","Pearson.est","potassium channel blocker",-0.63349,-1.79,0.0263,1205,0.158,"dofetilide, mepivacaine, ibutilide, meglitinide",1.58004425151024,0.801342913045577,TRUE +"H3255","Pearson.est","PPAR receptor agonist",-0.29676,-0.872,0.631,1404,0.797,"clofibrate",0.199970640755866,0.0985416786038876,FALSE +"H3255","Pearson.est","progesterone receptor agonist",-0.50956,-1.45,0.114,1253,0.281,"nomegestrol.acetate, dienogest, danazol, norethindrone.acetate",0.943095148663527,0.55129368009492,FALSE +"H3255","Pearson.est","proteasome inhibitor",0.48433,1.18,0.282,745,0.56,"ONX.0914, carfilzomib, MG.132, delanzomib, bortezomib, ixazomib.citrate, ixazomib",0.549750891680639,0.2518119729938,FALSE +"H3255","Pearson.est","protein synthesis inhibitor",0.62978,1.53,0.0509,290,0.266,"bruceantin, harringtonine, anguidine, azomycin..2.nitroimidazole., homoharringtonine, thiostrepton, mercaptopurine, florfenicol, tedizolid.phosphate",1.29328221766324,0.575118363368933,FALSE +"H3255","Pearson.est","protein tyrosine kinase inhibitor",0.73666,1.81,0.00404,200,0.118,"mubritinib, CP.724714, tyrphostin.A9, BMS.599626, NVP.TAE226",2.3936186348894,0.928117992693875,TRUE +"H3255","Pearson.est","RAF inhibitor",0.51326,1.25,0.215,533,0.484,"sorafenib, SB.590885, regorafenib, TAK.632, PLX.4720, RAF265, GDC.0879, CEP.32496, AZ.628",0.667561540084395,0.315154638355588,FALSE +"H3255","Pearson.est","RET tyrosine kinase inhibitor",0.53049,1.29,0.183,571,0.493,"sorafenib, regorafenib, apatinib, sunitinib, cabozantinib",0.737548910269571,0.30715308072277,FALSE +"H3255","Pearson.est","retinoid receptor agonist",0.56393,1.36,0.146,323,0.405,"bexarotene, fenretinide, adarotene, CD.437",0.835647144215563,0.392544976785331,FALSE +"H3255","Pearson.est","ribonucleotide reductase inhibitor",-0.22184,-0.655,0.864,319,0.987,"cytarabine, LY2334737, gemcitabine, cladribine, fludarabine.phosphate, pentostatin, clofarabine, triapine, hydroxyurea, fludarabine",0.0634862575211067,0.00568284733036327,FALSE +"H3255","Pearson.est","serotonin receptor agonist",-0.53133,-1.44,0.129,1350,0.265,"NAN.190, aripiprazole",0.889410289700751,0.576754126063192,FALSE +"H3255","Pearson.est","serotonin receptor antagonist",0.39811,0.983,0.497,56,0.735,"sertindole, lurasidone",0.303643611266668,0.133712660915805,FALSE +"H3255","Pearson.est","sodium channel blocker",0.34739,0.842,0.658,567,0.773,"ajmaline, benzethonium, brivaracetam, lappaconite, benzocaine, butamben, A.803467, quinidine, triamterene",0.181774106386044,0.111820506081675,FALSE +"H3255","Pearson.est","src inhibitor",-0.52228,-1.48,0.0795,1258,0.314,"saracatinib, PP.1, PP.2, dasatinib",1.09963287134353,0.503070351926785,FALSE +"H3255","Pearson.est","sterol demethylase inhibitor",0.54023,1.34,0.162,524,0.421,"chlormidazole, sulconazole, posaconazole, ketoconazole",0.790484985457369,0.375717904164332,FALSE +"H3255","Pearson.est","TGF beta receptor inhibitor",0.48368,1.19,0.243,593,0.561,"SB.525334, adaprev, SB.431542, D.4476",0.614393726401688,0.251037138743839,FALSE +"H3255","Pearson.est","thymidylate synthase inhibitor",0.59193,1.46,0.0716,396,0.339,"trifluridine, raltitrexed, carmofur",1.14508697769214,0.469800301796918,FALSE +"H3255","Pearson.est","topoisomerase inhibitor",0.42811,1.07,0.381,624,0.671,"idarubicin, amonafide, TAS.103, epirubicin, SN.38, valrubicin, doxorubicin, irinotecan, genz.644282, exatecan.mesylate, etoposide.phosphate, daunorubicin, nemorubicin, amsacrine, teniposide, dexrazoxane, camptothecin, voreloxin",0.419075024324381,0.173277479831008,FALSE +"H3255","Pearson.est","tubulin polymerization inhibitor",0.5993,1.47,0.0791,384,0.348,"albendazole, nocodazole, taltobulin, indibulin, parbendazole, flubendazole, plinabulin, epothilone.b, oxibendazole, dolastatin.10, ABT.751, docetaxel, vinorelbine, combretastatin.A.4, vincristine, KX2.391, podophyllotoxin, paclitaxel",1.10182351650232,0.458420756053419,FALSE +"H3255","Pearson.est","tyrosine kinase inhibitor",0.42333,1.03,0.426,200,0.685,"mubritinib, bafetinib, CP.724714, tyrphostin.A9, sorafenib, regorafenib, BMS.599626, NVP.TAE226",0.370590400897281,0.164309428507574,FALSE +"H3255","Pearson.est","VEGFR inhibitor",0.40043,0.967,0.518,523,0.725,"golvatinib, sorafenib, pazopanib, BMS.690514, foretinib, regorafenib, OSI.930, vatalanib, tivozanib, motesanib, axitinib, AEE788, ZM.306416, XL.647, RAF265, sunitinib, PD.173074, dovitinib",0.285670240254767,0.139661993429006,FALSE +"H3255","Pearson.est","vitamin D receptor agonist",0.64784,1.57,0.04,424,0.282,"maxacalcitol, tacalcitol, paricalcitol, calcitriol, ercalcitriol, doxercalciferol",1.39794000867204,0.549750891680639,FALSE +"H1648","Pearson.est","EGFR inhibitor",-0.22011,-0.554,0.957,1043,0.954,"PD.153035, CP.724714, tyrphostin.AG.494, pelitinib, BIBU.1361, CGP.52411, rociletinib, tyrphostin.AG.1478, erlotinib, salvianolic.acid.B, icotinib, gefitinib",0.0190880622231565,0.0204516252959049,FALSE +"H1648","Pearson.est","Abl kinase inhibitor",-0.26095,-0.669,0.849,1038,0.901,"nilotinib, KW.2449, flumatinib, bosutinib",0.0710923097560473,0.045275209020937,FALSE +"H1648","Pearson.est","acetylcholine receptor agonist",-0.4388,-1.1,0.333,1444,0.449,"tremorine",0.47755576649368,0.347753658996677,FALSE +"H1648","Pearson.est","acetylcholine receptor antagonist",-0.59344,-1.51,0.0885,1304,0.291,"methscopolamine, dicycloverine",1.05305672930217,0.536107011014093,FALSE +"H1648","Pearson.est","adenosine receptor antagonist",-0.73314,-1.87,0.00935,1408,0.335,"istradefylline, SCH.58261",2.02918838912748,0.474955192963155,FALSE +"H1648","Pearson.est","adrenergic receptor agonist",-0.47382,-1.24,0.235,1144,0.383,"terbutaline, norepinephrine, A61603, xylazine, epinephrine, oxymetazoline, isoetharine",0.628932137728264,0.416801226031377,FALSE +"H1648","Pearson.est","adrenergic receptor antagonist",0.29744,0.783,0.722,243,0.874,"RS.17053, prazosin, practolol, oxprenolol, dronedarone, atenolol......",0.141462802430361,0.058488567365597,FALSE +"H1648","Pearson.est","AKT inhibitor",0.63986,1.68,0.0415,280,0.202,"GDC.0068, A.674563, GSK2110183, uprosertib, MK.2206, ONC201",1.38195190328791,0.694648630553376,TRUE +"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.44635,1.18,0.26,387,0.499,"alectinib, AZD3463, lorlatinib, brigatinib, DMH1, SB.505124",0.585026652029182,0.30189945437661,FALSE +"H1648","Pearson.est","androgen receptor antagonist",-0.68097,-1.72,0.0291,1248,0.193,"enzalutamide, flutamide",1.53610701101409,0.714442690992226,TRUE +"H1648","Pearson.est","antioxidant",-0.71458,-1.82,0.0113,1052,0.163,"rutin, taurine, trolox, mesna, chlorogenic.acid",1.94692155651658,0.787812395596042,TRUE +"H1648","Pearson.est","AP inhibitor",-0.55131,-1.39,0.13,1067,0.317,"tanshinone.i, idronoxil, LCL.161, birinapant, GDC.0152",0.886056647693163,0.498940737782249,FALSE +"H1648","Pearson.est","ATPase inhibitor",0.29044,0.769,0.732,50,0.832,"oligomycin.a, evodiamine",0.135488918941608,0.0798766737092761,FALSE +"H1648","Pearson.est","Aurora kinase inhibitor",0.63578,1.68,0.0335,237,0.202,"barasertib, alisertib, AT.9283, AMG900, aurora.a.inhibitor.i, TAK.901, barasertib.HQPA, ZM.447439, MK.5108, SNS.314, danusertib, PHA.680632, GSK1070916",1.47495519296315,0.694648630553376,TRUE +"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.23403,0.615,0.923,1111,0.947,"valnemulin, tilmicosin, azalomycin.b, tedizolid, josamycin, radezolid, dirithromycin, azithromycin",0.0347982989740879,0.0236500209967266,FALSE +"H1648","Pearson.est","bacterial DNA gyrase inhibitor",-0.42822,-1.1,0.333,1104,0.449,"sparfloxacin, lomefloxacin, finafloxacin, sarafloxacin",0.47755576649368,0.347753658996677,FALSE +"H1648","Pearson.est","BCL inhibitor",0.45819,1.18,0.259,488,0.499,"obatoclax, TW.37, venetoclax, ABT.737, gossypol",0.586700235918748,0.30189945437661,FALSE +"H1648","Pearson.est","Bcr.Abl kinase inhibitor",-0.28836,-0.745,0.754,1272,0.858,"flumatinib, bosutinib",0.122628654130226,0.0665127121512946,FALSE +"H1648","Pearson.est","benzodiazepine receptor agonist",-0.26927,-0.689,0.842,943,0.905,"lorazepam, CL.218872, zaleplon, temazepam, gamma.aminobutyric.acid, piperazine",0.0746879085003505,0.0433514207947967,FALSE +"H1648","Pearson.est","bromodomain inhibitor",0.82954,2.15,0.00204,105,0.0366,"OTX015, I.BET151, JQ1....",2.6903698325741,1.43651891460559,TRUE +"H1648","Pearson.est","calcium channel blocker",0.5426,1.42,0.121,215,0.298,"carboxyamidotriazole, pranidipine, SR.33805, penfluridol",0.91721462968355,0.525783735923745,FALSE +"H1648","Pearson.est","CC chemokine receptor antagonist",-0.48548,-1.24,0.217,1227,0.383,"navarixin, MK.0812, RS.504393",0.66354026615147,0.416801226031377,FALSE +"H1648","Pearson.est","CDK inhibitor",0.50129,1.33,0.18,265,0.335,"R547, indisulam, BMS.387032, abemaciclib, ribociclib, AT.7519, palbociclib, NU6027, TG.02",0.744727494896694,0.474955192963155,FALSE +"H1648","Pearson.est","CHK inhibitor",-0.61917,-1.58,0.0559,1039,0.263,"PF.477736, SCH.900776, AZD7762, LY2606368",1.25258819211358,0.580044251510242,FALSE +"H1648","Pearson.est","cyclooxygenase inhibitor",-0.49702,-1.24,0.224,1171,0.383,"aspirin, ramifenazone, amfenac, indoprofen, FK.3311, FR.122047, sulfasalazine",0.649751981665837,0.416801226031377,FALSE +"H1648","Pearson.est","cytochrome P450 inhibitor",-0.6995,-1.84,0.0157,1359,0.213,"eplerenone, morin, itraconazole",1.80410034759077,0.671620396561262,TRUE +"H1648","Pearson.est","DNA alkylating agent",0.54777,1.4,0.133,90,0.302,"melphalan, mitomycin.c, ifosfamide, satraplatin, TH.302",0.876148359032914,0.519993057042849,FALSE +"H1648","Pearson.est","DNA inhibitor",0.28203,0.718,0.777,182,0.847,"melphalan, sangivamycin, chlorambucil, pibenzimol",0.109578981199086,0.0721165896692931,FALSE +"H1648","Pearson.est","DNA methyltransferase inhibitor",0.67144,1.75,0.0261,288,0.248,"fdcyd, SGI.1027, azacitidine, disulfiram",1.58335949266172,0.605548319173784,TRUE +"H1648","Pearson.est","DNA polymerase inhibitor",0.32441,0.845,0.626,509,0.818,"cephalomannine, menadione, trifluridine, foscarnet, cidofovir, adefovir.dipivoxil",0.20342566678957,0.087246696328677,FALSE +"H1648","Pearson.est","DNA synthesis inhibitor",0.43913,1.14,0.306,41,0.468,"mitomycin.c, floxuridine, enocitabine",0.51427857351842,0.329754146925876,FALSE +"H1648","Pearson.est","dopamine receptor antagonist",-0.44596,-1.15,0.307,1249,0.419,"acetophenazine, remoxipride, UH.232...., thioproperazine, piperacetazine, raclopride",0.512861624522813,0.377785977033705,FALSE +"H1648","Pearson.est","estrogen receptor agonist",-0.58593,-1.48,0.0882,1258,0.238,"ethinyl.estradiol, estradiol.cypionate, estradiol",1.05453141486818,0.623423042943488,FALSE +"H1648","Pearson.est","estrogen receptor antagonist",-0.4644,-1.2,0.25,1203,0.394,"raloxifene, tamoxifen",0.602059991327962,0.404503778174426,FALSE +"H1648","Pearson.est","FGFR inhibitor",0.74945,1.92,0.00622,203,0.0926,"regorafenib, dovitinib, lenvatinib, erdafitinib, AZD4547, PD.173074",2.20620961530918,1.03338901331807,TRUE +"H1648","Pearson.est","FLT3 inhibitor",0.34092,0.903,0.56,438,0.761,"sorafenib, sunitinib, dovitinib, quizartinib, TG.02, TG.101348, pacritinib, ENMD.2076, ponatinib",0.2518119729938,0.118615343229427,FALSE +"H1648","Pearson.est","glucocorticoid receptor agonist",-0.60544,-1.56,0.0789,966,0.258,"betamethasone, halobetasol.propionate, fluorometholone, triamcinolone, clobetasol.propionate, flumethasone, hydrocortisone, triamcinolone.acetonide, fluticasone.propionate, piretanide, rimexolone, fludroxycortide, fluocinolone.acetonide, dexamethasone.acetate, prednisolone.acetate, beclomethasone.dipropionate",1.10292299679058,0.58838029403677,FALSE +"H1648","Pearson.est","glutamate receptor antagonist",-0.53731,-1.38,0.14,1420,0.309,"kynurenic.acid, JNJ.16259685, SIB.1757",0.853871964321762,0.510041520575165,FALSE +"H1648","Pearson.est","glycogen synthase kinase inhibitor",-0.58545,-1.48,0.104,1099,0.238,"GSK.3.inhibitor.IX, tideglusib, TWS.119, LY2090314, indirubin",0.98296666070122,0.623423042943488,FALSE +"H1648","Pearson.est","growth factor receptor inhibitor",0.38809,1,0.412,198,0.62,"GW.441756, AZD3463, danusertib",0.385102783966865,0.207608310501746,FALSE +"H1648","Pearson.est","HCV inhibitor",0.31433,0.82,0.684,267,0.836,"embelin, narlaprevir",0.164943898279884,0.0777937225609836,FALSE +"H1648","Pearson.est","HDAC inhibitor",-0.34631,-0.883,0.58,1285,0.723,"dacinostat, panobinostat, mocetinostat, trichostatin.a, nexturastat.a",0.236572006437063,0.140861702705469,FALSE +"H1648","Pearson.est","histamine receptor antagonist",-0.5086,-1.3,0.187,903,0.364,"cimetidine, ICI.162846, tiotidine, ranitidine, BF2.649, nizatidine, terfenadine, chloropyramine, cyproheptadine, zolantidine, famotidine, lafutidine",0.728158393463501,0.438898616350944,FALSE +"H1648","Pearson.est","HMGCR inhibitor",-0.41529,-1.05,0.393,1241,0.498,"lovastatin, fluvastatin",0.405607449624573,0.302770657240282,FALSE +"H1648","Pearson.est","HSP inhibitor",0.27136,0.718,0.782,320,0.847,"tanespimycin, NMS.E973, KW.2478, VER.49009",0.106793246940152,0.0721165896692931,FALSE +"H1648","Pearson.est","JAK inhibitor",-0.312,-0.798,0.687,1222,0.832,"atiprimod, CEP.33779, WHI.P154, AZD1480",0.16304326294045,0.0798766737092761,FALSE +"H1648","Pearson.est","KIT inhibitor",0.58979,1.5,0.0785,322,0.282,"motesanib, regorafenib, sorafenib, sunitinib, pazopanib, lenvatinib, OSI.930, cediranib, imatinib",1.10513034325475,0.549750891680639,FALSE +"H1648","Pearson.est","MDM inhibitor",0.62003,1.63,0.0474,507,0.214,"CGM097, RITA, idasanutlin, AMG.232, serdemetan",1.32422165832591,0.669586226650809,TRUE +"H1648","Pearson.est","MEK inhibitor",-0.47003,-1.21,0.261,878,0.399,"AS.703026, PD.98059, AZD8330, cobimetinib, PD.198306, PD.0325901, selumetinib, trametinib, Ro.4987655, TAK.733, MEK162, MEK1.2.inhibitor, PD.318088, refametinib, BIX.02188, PD.184352",0.583359492661719,0.399027104313252,FALSE +"H1648","Pearson.est","MET inhibitor",-0.6568,-1.69,0.0318,1116,0.166,"LY2801653, NVP.BVU972, PHA.665752, PF.04217903",1.49757288001557,0.779891911959945,TRUE +"H1648","Pearson.est","microtubule inhibitor",0.31862,0.849,0.61,516,0.835,"cabazitaxel, podophyllotoxin, vinflunine, cytochalasin.b, D.64131, triclabendazole",0.214670164989233,0.0783135245163979,FALSE +"H1648","Pearson.est","mTOR inhibitor",0.63001,1.6,0.0583,287,0.229,"PI.103, PF.05212384, GSK2126458, GDC.0980, temsirolimus, torin.2, everolimus, voxtalisib, PP242, SB.2343, MLN0128, AZD2014, LY303511, ku.0063794, torin.1, WYE.125132, OSI.027",1.23433144524099,0.640164517660112,FALSE +"H1648","Pearson.est","NFkB pathway inhibitor",-0.30182,-0.767,0.739,922,0.853,"IKK.2.inhibitor.V, curcumin, Ro.106.9920, BAY.11.7082, tyloxapol, parthenolide",0.131355561605174,0.069050968832477,FALSE +"H1648","Pearson.est","opioid receptor agonist",-0.71882,-1.81,0.0168,1109,0.134,"salvinorin.a, ADL5859, BW.180C, cebranopadol",1.77469071827414,0.872895201635192,TRUE +"H1648","Pearson.est","p38 MAPK inhibitor",0.59309,1.5,0.0973,427,0.282,"VX.702, skepinone.l, CMPD.1, talmapimod, SB.239063",1.01188715973165,0.549750891680639,FALSE +"H1648","Pearson.est","PARP inhibitor",0.45597,1.17,0.3,285,0.493,"niraparib, E7449, AZD2461, olaparib, talazoparib",0.522878745280338,0.30715308072277,FALSE +"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.57019,1.49,0.102,137,0.26,"motesanib, regorafenib, sorafenib, trapidil, sunitinib, pazopanib, dovitinib, lenvatinib",0.991399828238082,0.585026652029182,FALSE +"H1648","Pearson.est","phosphatase inhibitor",0.44522,1.15,0.304,155,0.487,"mycophenolate.mofetil, mycophenolic.acid, GSK2830371",0.517126416391246,0.312471038785366,FALSE +"H1648","Pearson.est","phosphodiesterase inhibitor",-0.58585,-1.49,0.0879,1297,0.289,"GSK256066, avanafil, papaverine",1.05601112492623,0.539102157243452,FALSE +"H1648","Pearson.est","PI3K inhibitor",0.66393,1.73,0.042,276,0.231,"PI.103, PIK.75, taselisib, PI.828, alpelisib, PF.05212384, GSK2126458, GDC.0980, buparlisib, voxtalisib, SB.2343, BGT226, YM.201636, LY303511, CUDC.907, PI3K.IN.2",1.3767507096021,0.636388020107856,TRUE +"H1648","Pearson.est","PLK inhibitor",0.60895,1.53,0.0721,522,0.287,"NMS.1286937, GSK461364, BI.2536, volasertib, GW.843682X, HMN.214",1.14206473528057,0.542118103266008,FALSE +"H1648","Pearson.est","potassium channel blocker",-0.43453,-1.15,0.27,1323,0.419,"meglitinide",0.568636235841013,0.377785977033705,FALSE +"H1648","Pearson.est","PPAR receptor agonist",0.29698,0.769,0.734,521,0.832,"pterostilbene, fenofibrate, clofibrate, oleoylethanolamide",0.134303940083929,0.0798766737092761,FALSE +"H1648","Pearson.est","progesterone receptor agonist",-0.67162,-1.69,0.0391,1084,0.166,"dienogest, norethindrone.acetate, nomegestrol.acetate, norethindrone, tanaproget, norgestrel",1.40782324260413,0.779891911959945,TRUE +"H1648","Pearson.est","proteasome inhibitor",0.39039,1.03,0.418,405,0.59,"delanzomib, ONX.0914, MG.132",0.378823718224965,0.229147988357856,FALSE +"H1648","Pearson.est","protein synthesis inhibitor",0.4296,1.14,0.318,121,0.468,"clofoctol, anguidine, harringtonine, azomycin..2.nitroimidazole.",0.497572880015567,0.329754146925876,FALSE +"H1648","Pearson.est","protein tyrosine kinase inhibitor",0.2342,0.597,0.929,227,0.944,"mubritinib, tyrphostin.A9",0.0319842860063582,0.025028005701931,FALSE +"H1648","Pearson.est","RAF inhibitor",0.54449,1.49,0.0909,143,0.26,"regorafenib, sorafenib, AZ.628",1.04143611677803,0.585026652029182,FALSE +"H1648","Pearson.est","RET tyrosine kinase inhibitor",0.83113,2.14,0,193,0.0189,"regorafenib, sorafenib, cabozantinib, sunitinib, apatinib",Inf,1.72353819582676,TRUE +"H1648","Pearson.est","retinoid receptor agonist",0.76432,2.04,0.00221,221,0.0467,"adarotene, fenretinide, tamibarotene, bexarotene, AM.580, adapalene",2.65560772631489,1.33068311943389,TRUE +"H1648","Pearson.est","ribonucleotide reductase inhibitor",0.54349,1.42,0.0966,341,0.298,"gemcitabine, LY2334737, fludarabine.phosphate, clofarabine, cytarabine",1.01502287358451,0.525783735923745,FALSE +"H1648","Pearson.est","serotonin receptor agonist",-0.52119,-1.35,0.175,1070,0.325,"pardoprunox, SR.57227A, zolmitriptan, NAN.190",0.756961951313706,0.488116639021126,FALSE +"H1648","Pearson.est","serotonin receptor antagonist",0.41151,1.06,0.368,333,0.563,"sertindole, aripiprazole, ziprasidone, lurasidone",0.434152181326482,0.249491605148654,FALSE +"H1648","Pearson.est","sodium channel blocker",0.17514,0.462,0.988,328,0.991,"brivaracetam, triamterene, benzethonium, cibenzoline",0.00524305541237188,0.00392634551472468,FALSE +"H1648","Pearson.est","src inhibitor",-0.58395,-1.48,0.0938,1327,0.238,"bosutinib, PP.1, PP.2",1.02779716162094,0.623423042943488,FALSE +"H1648","Pearson.est","sterol demethylase inhibitor",0.30153,0.782,0.712,359,0.853,"ketoconazole, chlormidazole, sulconazole",0.147520006363144,0.069050968832477,FALSE +"H1648","Pearson.est","TGF beta receptor inhibitor",0.28607,0.727,0.778,515,0.874,"repsox, SB.525334, LY2109761",0.109020403010311,0.058488567365597,FALSE +"H1648","Pearson.est","thymidylate synthase inhibitor",0.65313,1.71,0.0424,458,0.222,"raltitrexed, carmofur, trifluridine, capecitabine, doxifluridine",1.37263414340727,0.653647025549361,TRUE +"H1648","Pearson.est","topoisomerase inhibitor",0.6411,1.64,0.0438,342,0.225,"epirubicin, nemorubicin, exatecan.mesylate, topotecan, teniposide, amsacrine, idarubicin, etoposide.phosphate, doxorubicin, rubitecan, amonafide, irinotecan, daunorubicin, TAS.103, genz.644282, dexrazoxane, SN.38, camptothecin",1.3585258894959,0.647817481888638,TRUE +"H1648","Pearson.est","tubulin polymerization inhibitor",0.52197,1.37,0.149,388,0.305,"mebendazole, parbendazole, vincristine, indibulin, taltobulin, combretastatin.A.4, oxibendazole, dolastatin.10, plinabulin, epothilone.b, KX2.391, albendazole, vinorelbine, verubulin, podophyllotoxin",0.826813731587726,0.515700160653214,FALSE +"H1648","Pearson.est","tyrosine kinase inhibitor",0.45294,1.16,0.282,227,0.489,"regorafenib, sorafenib, cabozantinib, bafetinib, sunitinib, apatinib, mubritinib, tyrphostin.A9",0.549750891680639,0.31069114087638,FALSE +"H1648","Pearson.est","VEGFR inhibitor",0.53339,1.37,0.143,457,0.305,"motesanib, foretinib, regorafenib, sorafenib, cabozantinib, sunitinib, pazopanib, dovitinib, lenvatinib, TG.100572, PD.173074, OSI.930, golvatinib, cediranib, tivozanib, RAF265, AEE788, BMS.690514, XL.647, ENMD.2076, axitinib, orantinib, linifanib, vatalanib",0.844663962534938,0.515700160653214,FALSE +"H1648","Pearson.est","vitamin D receptor agonist",-0.26025,-0.658,0.85,829,0.888,"alfacalcidol, doxercalciferol, ercalcitriol, paricalcitol, calcitriol",0.0705810742857073,0.051587034221399,FALSE +"H1975","Pearson.est","EGFR inhibitor",0.47283,1.19,0.247,345,0.673,"tucatinib, poziotinib, lapatinib, AZD8931, dacomitinib, neratinib, BMS.690514, CUDC.101, CP.724714, TAK.285, osimertinib, AST.1306, afatinib, GW.583340, AEE788, ARRY.334543, WZ.3146, BIBU.1361, WZ.4002",0.607303046740334,0.171984935776023,FALSE +"H1975","Pearson.est","Abl kinase inhibitor",-0.66334,-1.71,0.039,1164,0.179,"bosutinib, nilotinib, GZD824, tozasertib, KW.2449, ZM.306416, metatinib, ponatinib, dasatinib",1.4089353929735,0.747146969020107,TRUE +"H1975","Pearson.est","acetylcholine receptor agonist",-0.54108,-1.39,0.143,1261,0.353,"tremorine, nicotine",0.844663962534938,0.452225294612177,FALSE +"H1975","Pearson.est","acetylcholine receptor antagonist",0.41792,1.03,0.434,119,0.804,"diphemanil, hyoscyamine",0.362510270487489,0.0947439512515487,FALSE +"H1975","Pearson.est","adenosine receptor antagonist",0.85585,2.16,0,54,0.00532,"MRS.1220, CGS.15943, SCH.58261",Inf,2.27408836770495,TRUE +"H1975","Pearson.est","adrenergic receptor agonist",-0.48719,-1.23,0.241,1103,0.454,"oxymetazoline, ritodrine, terbutaline, A61603, clenbuterol, epinephrine, isoxsuprine, midodrine",0.617982957425132,0.342944147142896,FALSE +"H1975","Pearson.est","adrenergic receptor antagonist",0.36973,0.92,0.521,210,0.88,"practolol, prazosin, propranolol, atipamezole, atenolol......",0.283162276700476,0.0555173278498314,FALSE +"H1975","Pearson.est","AKT inhibitor",0.57653,1.45,0.107,46,0.389,"GDC.0068, uprosertib, GSK2110183",0.97061622231479,0.410050398674292,FALSE +"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.47706,-1.24,0.201,1252,0.499,"AZD3463, lorlatinib, brigatinib, AP26113",0.696803942579511,0.30189945437661,FALSE +"H1975","Pearson.est","androgen receptor antagonist",-0.36028,-0.921,0.532,1182,0.722,"cyproterone.acetate, enzalutamide",0.274088367704952,0.141462802430361,FALSE +"H1975","Pearson.est","antioxidant",-0.68835,-1.77,0.018,1004,0.147,"mesna, chlorogenic.acid, trolox, taurine, benfotiamine",1.74472749489669,0.832682665251824,TRUE +"H1975","Pearson.est","AP inhibitor",-0.31858,-0.815,0.67,1411,0.842,"idronoxil",0.173925197299174,0.0746879085003505,FALSE +"H1975","Pearson.est","ATPase inhibitor",0.35504,0.863,0.635,126,0.935,"evodiamine, oligomycin.a, NMS.873",0.197226274708024,0.0291883891274822,FALSE +"H1975","Pearson.est","Aurora kinase inhibitor",0.32233,0.798,0.694,530,0.921,"PHA.680632, TAK.901, aurora.a.inhibitor.i, danusertib, barasertib.HQPA, CCT137690, barasertib, alisertib, SNS.314, PF.03814735, MLN.8054, ENMD.2076, AT.9283",0.158640529545145,0.0357403698031511,FALSE +"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.19306,0.487,0.973,1170,0.982,"radezolid, valnemulin, tedizolid, josamycin, tilmicosin, azithromycin, azalomycin.b, dirithromycin",0.0118871597316481,0.00788851221305034,FALSE +"H1975","Pearson.est","bacterial DNA gyrase inhibitor",0.61474,1.54,0.0628,308,0.419,"trovafloxacin, nadifloxacin, sarafloxacin",1.2020403562628,0.377785977033705,FALSE +"H1975","Pearson.est","BCL inhibitor",0.56585,1.42,0.112,352,0.409,"TW.37, HA14.1, obatoclax, gossypol",0.950781977329818,0.388276691992658,FALSE +"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.63151,-1.58,0.0532,1164,0.237,"bosutinib, nilotinib, GZD824, tozasertib, metatinib, ponatinib, dasatinib",1.27408836770495,0.625251653989896,FALSE +"H1975","Pearson.est","benzodiazepine receptor agonist",0.59026,1.48,0.108,173,0.443,"ZK.93423, piperazine, zaleplon, ivermectin, gamma.aminobutyric.acid",0.96657624451305,0.35359627377693,FALSE +"H1975","Pearson.est","bromodomain inhibitor",0.9087,2.25,0,47,0.00106,"I.BET151, OTX015, JQ1...., I.BET.762, bromosporine",Inf,2.97469413473523,TRUE +"H1975","Pearson.est","calcium channel blocker",0.63835,1.61,0.0459,292,0.378,"SR.33805, cinnarazine, pranidipine, mibefradil, SKF.96365",1.33818731446274,0.422508200162775,FALSE +"H1975","Pearson.est","CC chemokine receptor antagonist",0.51465,1.3,0.186,84,0.559,"SB.225002, ZK811752",0.730487055782084,0.252588192113577,FALSE +"H1975","Pearson.est","CDK inhibitor",-0.25915,-0.684,0.844,1174,0.915,"dinaciclib, AT.7519, AZD5438, abemaciclib, aminopurvalanol.a, alvocidib, PHA.848125",0.073657553374345,0.0385789059335517,FALSE +"H1975","Pearson.est","CHK inhibitor",-0.76883,-1.99,0.00222,1192,0.0648,"PF.477736, CHIR.124, LY2603618, AZD7762, SCH.900776, LY2606368",2.65364702554936,1.18842499412941,TRUE +"H1975","Pearson.est","cyclooxygenase inhibitor",0.39979,1,0.417,444,0.775,"piroxicam, pterostilbene, naproxen, curcumin, AM.404, ramifenazone, meloxicam, tepoxalin, tryptanthrin, amfenac",0.379863945026242,0.11069829749369,FALSE +"H1975","Pearson.est","cytochrome P450 inhibitor",-0.59317,-1.54,0.0583,1275,0.231,"metyrapone, eplerenone, itraconazole",1.23433144524099,0.636388020107856,FALSE +"H1975","Pearson.est","DNA alkylating agent",-0.29426,-0.762,0.722,1413,0.864,"streptozotocin, carboplatin",0.141462802430361,0.0634862575211067,FALSE +"H1975","Pearson.est","DNA inhibitor",0.20786,0.522,0.968,441,1,"chlorambucil, primaquine, oxaliplatin, melphalan, valrubicin, metronidazole, teroxirone",0.0141246426916063,0,FALSE +"H1975","Pearson.est","DNA methyltransferase inhibitor",0.56036,1.39,0.125,164,0.433,"fdcyd, SGI.1027, azacitidine",0.903089986991944,0.363512103646635,FALSE +"H1975","Pearson.est","DNA polymerase inhibitor",-0.30598,-0.778,0.709,1028,0.87,"foscarnet, menadione, famciclovir",0.149353764816933,0.0604807473813815,FALSE +"H1975","Pearson.est","DNA synthesis inhibitor",0.22198,0.557,0.943,561,1,"floxuridine, anisomycin, artemisinin, enocitabine, mitomycin.c, artesunate, estramustine.phosphate, azodicarbonamide",0.0254883072626717,0,FALSE +"H1975","Pearson.est","dopamine receptor antagonist",0.25793,0.644,0.875,122,1,"lurasidone, sertindole, clebopride",0.0579919469776868,0,FALSE +"H1975","Pearson.est","estrogen receptor agonist",-0.54265,-1.4,0.141,1216,0.367,"estradiol, estradiol.cypionate, PPT",0.85078088734462,0.435333935747911,FALSE +"H1975","Pearson.est","estrogen receptor antagonist",0.40272,1,0.452,159,0.775,"clomifene, fulvestrant",0.344861565188618,0.11069829749369,FALSE +"H1975","Pearson.est","FGFR inhibitor",-0.33875,-0.878,0.545,1304,0.766,"lucitanib, AZD4547",0.263603497723358,0.115771230367396,FALSE +"H1975","Pearson.est","FLT3 inhibitor",-0.43881,-1.12,0.333,1237,0.565,"tozasertib, tyrphostin.AG.1296, KW.2449, midostaurin, ponatinib, gilteritinib",0.47755576649368,0.247951552180562,FALSE +"H1975","Pearson.est","glucocorticoid receptor agonist",-0.1953,-0.505,0.967,1205,0.976,"triamcinolone, dexamethasone.acetate, flumethasone.pivalate, prednisolone.acetate, fluorometholone, fluocinolone.acetonide",0.0145735259169983,0.0105501823333082,FALSE +"H1975","Pearson.est","glutamate receptor antagonist",-0.21611,-0.555,0.957,1055,1,"tiletamine, LY456236, JNJ.16259685, SIB.1757",0.0190880622231565,0,FALSE +"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.4039,-1.04,0.374,975,0.638,"AZD2858, GSK.3.inhibitor.IX, indirubin, TWS.119, LY2090314, CHIR.98014, tideglusib",0.42712839779952,0.195179321278838,FALSE +"H1975","Pearson.est","growth factor receptor inhibitor",-0.50912,-1.32,0.176,1187,0.413,"GSK1838705A, AZD3463, PHA.848125",0.75448733218585,0.384049948343599,FALSE +"H1975","Pearson.est","HCV inhibitor",0.41202,1.04,0.417,479,0.818,"PSI.7976, daclatasvir, embelin, Ro.9187, mericitabine",0.379863945026242,0.087246696328677,FALSE +"H1975","Pearson.est","HDAC inhibitor",0.3181,0.808,0.683,472,0.93,"R306465, M.344, RGFP966, ACY.1215, AR.42, romidepsin, tacedinaline, pyroxamide, PCI.24781, scriptaid, NSC.3852",0.165579296318467,0.0315170514460649,FALSE +"H1975","Pearson.est","histamine receptor antagonist",0.38714,0.994,0.451,307,0.759,"chloropyramine, ranitidine, epinastine, ICI.162846, cimetidine",0.345823458122039,0.11975822410452,FALSE +"H1975","Pearson.est","HMGCR inhibitor",-0.83844,-2.17,0,1334,0.0257,"lovastatin, mevastatin, pitavastatin, fluvastatin",Inf,1.59006687666871,TRUE +"H1975","Pearson.est","HSP inhibitor",0.31531,0.761,0.739,496,0.935,"NMS.E973, guanidine, tanespimycin, BIIB021, SNX.5422, VER.49009, XL888",0.131355561605174,0.0291883891274822,FALSE +"H1975","Pearson.est","JAK inhibitor",-0.27194,-0.695,0.812,983,0.93,"TG.101209, WHI.P154, ruxolitinib, AZ960, PRT062070, tozasertib, CEP.33779",0.0904439707588247,0.0315170514460649,FALSE +"H1975","Pearson.est","KIT inhibitor",-0.44169,-1.18,0.237,1314,0.499,"telatinib, midostaurin, KI.8751, dasatinib",0.625251653989896,0.30189945437661,FALSE +"H1975","Pearson.est","MDM inhibitor",0.6742,1.71,0.0284,445,0.411,"nutlin.3, idasanutlin, AMG.232, RITA, CGM097",1.54668165995296,0.386158178123931,FALSE +"H1975","Pearson.est","MEK inhibitor",-0.60835,-1.54,0.0682,1010,0.231,"MEK1.2.inhibitor, PD.318088, Ro.4987655, selumetinib, trametinib, TAK.733, AZD8330, MEK162, PD.184352, refametinib, cobimetinib, nobiletin, BIX.02188",1.16621562534352,0.636388020107856,FALSE +"H1975","Pearson.est","MET inhibitor",-0.65001,-1.67,0.035,1263,0.191,"PHA.665752, LY2801653",1.45593195564972,0.718966632752272,TRUE +"H1975","Pearson.est","microtubule inhibitor",-0.36096,-0.957,0.479,1013,0.755,"secnidazole, cabazitaxel, colchicine, vinblastine, D.64131, cytochalasin.b",0.319664486585437,0.122053048370812,FALSE +"H1975","Pearson.est","mTOR inhibitor",0.46173,1.16,0.28,392,0.697,"PF.05212384, WYE.125132, PI.103, sirolimus, GSK2126458, voxtalisib, PP242, everolimus, torin.1, deforolimus, GDC.0980, PKI.179, temsirolimus, torin.2",0.552841968657781,0.156767221901991,FALSE +"H1975","Pearson.est","NFkB pathway inhibitor",0.32335,0.809,0.69,293,0.955,"EVP4593, curcumin, BAY.11.7085",0.161150909262745,0.0199966284162537,FALSE +"H1975","Pearson.est","opioid receptor agonist",0.24064,0.594,0.925,1101,1,"salvinorin.a, spiradoline, ADL5859, cebranopadol, BW.180C, trimebutine",0.0338582672609674,0,FALSE +"H1975","Pearson.est","p38 MAPK inhibitor",0.66312,1.67,0.027,230,0.318,"skepinone.l, SB.242235, SB.239063",1.56863623584101,0.497572880015567,FALSE +"H1975","Pearson.est","PARP inhibitor",0.42512,1.07,0.35,474,0.822,"PJ.34, niraparib, AG.14361, AZD2461",0.455931955649724,0.0851281824599496,FALSE +"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.36377,-0.938,0.492,1243,0.724,"SU014813, crenolanib, telatinib, KI.8751, ponatinib, dasatinib",0.30803489723264,0.140261433802853,FALSE +"H1975","Pearson.est","phosphatase inhibitor",0.27307,0.687,0.84,178,1,"mycophenolate.mofetil, mycophenolic.acid",0.0757207139381184,0,FALSE +"H1975","Pearson.est","phosphodiesterase inhibitor",-0.36447,-0.954,0.512,1094,0.727,"anagrelide, trequinsin, GSK256066, papaverine, YM.976",0.290730039024169,0.138465589140962,FALSE +"H1975","Pearson.est","PI3K inhibitor",0.55917,1.45,0.107,374,0.389,"PF.05212384, taselisib, alpelisib, PI.103, PI.828, CH5132799, GSK2126458, buparlisib, CUDC.907, voxtalisib, YM.201636, GDC.0980, PI3K.IN.2, PKI.179, BGT226",0.97061622231479,0.410050398674292,FALSE +"H1975","Pearson.est","PLK inhibitor",0.47714,1.2,0.268,224,0.729,"HMN.214, GW.843682X",0.571865205971211,0.137272471682025,FALSE +"H1975","Pearson.est","potassium channel blocker",-0.47468,-1.23,0.225,1382,0.454,"meglitinide",0.647817481888638,0.342944147142896,FALSE +"H1975","Pearson.est","PPAR receptor agonist",0.61216,1.54,0.0691,108,0.419,"pterostilbene, ciprofibrate",1.1605219526258,0.377785977033705,FALSE +"H1975","Pearson.est","progesterone receptor agonist",-0.74574,-1.98,0.00227,1311,0.0469,"norethindrone, danazol, norethindrone.acetate, dienogest, nomegestrol.acetate",2.64397414280688,1.32882715728492,TRUE +"H1975","Pearson.est","proteasome inhibitor",0.24903,0.618,0.899,585,1,"ONX.0914, oprozomib, delanzomib, carfilzomib, MG.132",0.0462403082667712,0,FALSE +"H1975","Pearson.est","protein synthesis inhibitor",0.35324,0.892,0.552,438,0.907,"bruceantin, azomycin..2.nitroimidazole., harringtonine, clofoctol, thiostrepton, homoharringtonine, clindamycin.phosphate",0.258060922270801,0.0423927129399047,FALSE +"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.47182,1.19,0.261,255,0.673,"mubritinib, CP.724714, tyrphostin.A9",0.583359492661719,0.171984935776023,FALSE +"H1975","Pearson.est","RAF inhibitor",0.32005,0.809,0.67,398,0.955,"SB.590885, GDC.0879, AZ.628, regorafenib",0.173925197299174,0.0199966284162537,FALSE +"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.41217,1.02,0.433,667,0.792,"apatinib, regorafenib, sunitinib, sorafenib, cabozantinib",0.363512103646635,0.101274818410506,FALSE +"H1975","Pearson.est","retinoid receptor agonist",0.66961,1.67,0.0383,315,0.318,"adarotene, fenretinide, bexarotene, tamibarotene, AM.580",1.41680122603138,0.497572880015567,FALSE +"H1975","Pearson.est","ribonucleotide reductase inhibitor",0.30884,0.771,0.731,155,0.944,"cytarabine, LY2334737",0.13608262304214,0.025028005701931,FALSE +"H1975","Pearson.est","serotonin receptor agonist",-0.62501,-1.61,0.0487,1446,0.232,"aripiprazole",1.31247103878537,0.6345120151091,TRUE +"H1975","Pearson.est","serotonin receptor antagonist",-0.40827,-1.06,0.372,1343,0.634,"RS.16566, SB.216641, aripiprazole",0.429457060118102,0.197910742118267,FALSE +"H1975","Pearson.est","sodium channel blocker",0.40784,1.04,0.403,240,0.818,"benzethonium, ajmaline, quinidine, triamterene",0.39469495385889,0.087246696328677,FALSE +"H1975","Pearson.est","src inhibitor",-0.67804,-1.78,0.0243,1164,0.173,"bosutinib, PP.1, PP.2, ZM.306416, dasatinib",1.61439372640169,0.761953896871205,TRUE +"H1975","Pearson.est","sterol demethylase inhibitor",0.42946,1.09,0.352,167,0.814,"posaconazole, chlormidazole",0.453457336521869,0.0893755951107988,FALSE +"H1975","Pearson.est","TGF beta receptor inhibitor",0.59789,1.47,0.0983,243,0.421,"D.4476, SB.525334, adaprev, LY2109761",1.00744648216786,0.375717904164332,FALSE +"H1975","Pearson.est","thymidylate synthase inhibitor",0.34702,0.86,0.618,493,0.913,"raltitrexed, trifluridine, ftorafur, doxifluridine",0.209011524911184,0.039529222465701,FALSE +"H1975","Pearson.est","topoisomerase inhibitor",0.22743,0.582,0.946,78,1,"doxorubicin, etoposide.phosphate, epirubicin",0.0241088635982073,0,FALSE +"H1975","Pearson.est","tubulin polymerization inhibitor",0.21344,0.534,0.972,434,1,"taltobulin, indibulin, parbendazole, vincristine, vinorelbine, combretastatin.A.4, nocodazole, oxibendazole",0.0123337350737254,0,FALSE +"H1975","Pearson.est","tyrosine kinase inhibitor",-0.19936,-0.53,0.977,1296,0.995,"AMG.208, aminopurvalanol.a, dasatinib",0.0101054362812269,0.00217691925427455,FALSE +"H1975","Pearson.est","VEGFR inhibitor",0.20309,0.507,0.971,435,0.996,"BMS.690514, linifanib, golvatinib, lenvatinib, AEE788, orantinib, motesanib, foretinib, pazopanib, regorafenib, dovitinib, MGCD.265, OSI.930",0.0127807700919951,0.00174066157630127,FALSE +"H1975","Pearson.est","vitamin D receptor agonist",0.60223,1.52,0.0833,442,0.409,"calcitriol, maxacalcitol, paricalcitol, doxercalciferol, tacalcitol",1.07935499859321,0.388276691992658,FALSE +"HCC78","Pearson.est","EGFR inhibitor",-0.38824,-0.921,0.597,767,0.741,"FERb.033, CP.724714, tucatinib, BMS.690514, erlotinib, AZD8931, icotinib, PD.153035, brigatinib, neratinib, BIBX.1382, gefitinib, afatinib, OSI.420, TAK.285, BMS.599626, AST.1306, XL.647, salvianolic.acid.B, WZ.4002, rociletinib, WZ8040, vandetanib, BIBU.1361, ARRY.334543, GW.583340, osimertinib, CUDC.101",0.224025668870631,0.130181792020672,FALSE +"HCC78","Pearson.est","Abl kinase inhibitor",-0.6095,-1.43,0.0933,1069,0.36,"bosutinib, flumatinib, ponatinib, imatinib, metatinib, bafetinib, tozasertib, KW.2449",1.0301183562535,0.443697499232713,FALSE +"HCC78","Pearson.est","acetylcholine receptor agonist",-0.52997,-1.23,0.225,1122,0.478,"nefiracetam, pilocarpine",0.647817481888638,0.320572103387881,FALSE +"HCC78","Pearson.est","acetylcholine receptor antagonist",0.56796,1.64,0.0452,629,0.25,"hyoscyamine, diphemanil, darifenacin, dicycloverine, methscopolamine, iododexetimide",1.34486156518862,0.602059991327962,FALSE +"HCC78","Pearson.est","adenosine receptor antagonist",-0.46353,-1.1,0.353,1372,0.533,"CGS.15943",0.452225294612177,0.273272790973428,FALSE +"HCC78","Pearson.est","adrenergic receptor agonist",-0.20316,-0.472,0.984,787,0.987,"ritodrine, A61603, buphenine, isoetharine, metaraminol, isoxsuprine, clenbuterol, midodrine",0.00700490156865849,0.00568284733036327,FALSE +"HCC78","Pearson.est","adrenergic receptor antagonist",0.23956,0.676,0.837,114,0.862,"imiloxan, RS.17053, practolol",0.07727454200674,0.0644927341752872,FALSE +"HCC78","Pearson.est","AKT inhibitor",-0.63934,-1.5,0.0537,1195,0.329,"GDC.0068, ONC201, MK.2206, A.674563, uprosertib, triciribine",1.27002571430044,0.482804102050026,FALSE +"HCC78","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.47526,-1.14,0.301,1086,0.513,"crizotinib, NVP.TAE684, alectinib, AZD3463, CEP.37440, DMH1",0.521433504406157,0.289882634888184,FALSE +"HCC78","Pearson.est","androgen receptor antagonist",0.42441,1.28,0.182,836,0.396,"nilutamide, bicalutamide, flutamide, RU.58841, cyproterone.acetate, enzalutamide",0.739928612014925,0.402304814074488,FALSE +"HCC78","Pearson.est","antioxidant",-0.46751,-1.12,0.339,969,0.523,"trolox, chlorogenic.acid, taurine",0.469800301796918,0.281498311132726,FALSE +"HCC78","Pearson.est","AP inhibitor",0.48978,1.39,0.119,111,0.313,"birinapant, GDC.0152",0.924453038607469,0.504455662453552,FALSE +"HCC78","Pearson.est","ATPase inhibitor",0.35499,0.985,0.428,8,0.586,"k.strophanthidin, ouabain",0.368556230986828,0.232102383981909,FALSE +"HCC78","Pearson.est","Aurora kinase inhibitor",-0.69449,-1.64,0.0279,1180,0.2,"alisertib, PF.03814735, barasertib.HQPA, SNS.314, barasertib, MK.8745, ENMD.2076, AMG900, tozasertib, AT.9283, KW.2449, CCT137690, hesperadin, ZM.447439",1.5543957967264,0.698970004336019,TRUE +"HCC78","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.56364,-1.34,0.132,1025,0.427,"radezolid, dirithromycin, azalomycin.b, azithromycin, valnemulin",0.87942606879415,0.369572124974976,FALSE +"HCC78","Pearson.est","bacterial DNA gyrase inhibitor",0.5299,1.46,0.0894,306,0.276,"lomefloxacin, sarafloxacin, finafloxacin, trovafloxacin, sparfloxacin, norfloxacin",1.04866248120408,0.559090917934782,FALSE +"HCC78","Pearson.est","BCL inhibitor",-0.4918,-1.16,0.31,837,0.49,"ABT.737, oridonin, venetoclax, navitoclax, gossypol, TW.37",0.508638306165727,0.309803919971486,FALSE +"HCC78","Pearson.est","Bcr.Abl kinase inhibitor",-0.62167,-1.46,0.0794,1069,0.324,"bosutinib, flumatinib, ponatinib, imatinib, metatinib, bafetinib, tozasertib",1.1001794975729,0.489454989793388,FALSE +"HCC78","Pearson.est","benzodiazepine receptor agonist",0.29541,0.858,0.606,41,0.762,"eprinomectin, gamma.aminobutyric.acid",0.217527375833714,0.1180450286604,FALSE +"HCC78","Pearson.est","bromodomain inhibitor",-0.91886,-2.18,0,1325,0,"bromosporine, I.BET.762, PFI.1, OTX015, I.BET151, JQ1....",Inf,Inf,TRUE +"HCC78","Pearson.est","calcium channel blocker",-0.57594,-1.35,0.108,940,0.428,"cinnarazine, mibefradil, tetrandrine, SR.33805, carboxyamidotriazole, penfluridol",0.96657624451305,0.368556230986828,FALSE +"HCC78","Pearson.est","CC chemokine receptor antagonist",-0.5887,-1.39,0.0999,981,0.366,"MK.0812, RS.504393, SB.225002, navarixin, PF.04136309, ZK811752",1.00043451177402,0.436518914605589,FALSE +"HCC78","Pearson.est","CDK inhibitor",-0.72925,-1.72,0.0156,1258,0.148,"JNJ.7706621, AT.7519, BMS.265246, aminopurvalanol.a, indisulam, ribociclib, PHA.848125, TG.02, kenpaullone, AZD5438, dinaciclib, P276.00, alvocidib, palbociclib, abemaciclib",1.80687540164554,0.829738284605043,TRUE +"HCC78","Pearson.est","CHK inhibitor",-0.55673,-1.32,0.151,972,0.424,"SCH.900776, LY2606368, SB.218078, LY2603618",0.821023052706831,0.372634143407267,FALSE +"HCC78","Pearson.est","cyclooxygenase inhibitor",-0.34138,-0.793,0.753,1130,0.884,"ramifenazone, aspirin, phenazone, ketoprofen, tryptanthrin, FR.122047",0.123205023799299,0.0535477349869269,FALSE +"HCC78","Pearson.est","cytochrome P450 inhibitor",0.39976,1.18,0.243,163,0.445,"eplerenone, morin, metyrapone",0.614393726401688,0.351639989019068,FALSE +"HCC78","Pearson.est","DNA alkylating agent",-0.49835,-1.18,0.271,960,0.51,"satraplatin, ifosfamide, cisplatin, streptozotocin, melphalan, TH.302, cyclophosphamide, estramustine, mitomycin.c",0.567030709125594,0.292429823902064,FALSE +"HCC78","Pearson.est","DNA inhibitor",-0.22196,-0.527,0.969,980,1,"pibenzimol, mechlorethamine, melphalan, primaquine, teroxirone, oxaliplatin",0.0136762229492347,0,FALSE +"HCC78","Pearson.est","DNA methyltransferase inhibitor",-0.67841,-1.6,0.0263,1257,0.209,"azacitidine, decitabine, fdcyd",1.58004425151024,0.679853713888946,TRUE +"HCC78","Pearson.est","DNA polymerase inhibitor",-0.5469,-1.29,0.172,1223,0.429,"foscarnet, adefovir.dipivoxil, trifluridine, idoxuridine",0.764471553092451,0.367542707815276,FALSE +"HCC78","Pearson.est","DNA synthesis inhibitor",-0.48294,-1.13,0.31,1175,0.519,"artesunate, enocitabine, anisomycin, cyclocytidine, mitomycin.c",0.508638306165727,0.284832642151542,FALSE +"HCC78","Pearson.est","dopamine receptor antagonist",-0.20369,-0.48,0.985,805,1,"UH.232...., raclopride, lurasidone, mesoridazine, piperacetazine, paliperidone, acetophenazine, sertindole",0.00656376950238827,0,FALSE +"HCC78","Pearson.est","estrogen receptor agonist",0.27985,0.807,0.686,309,0.807,"ethinyl.estradiol, levonorgestrel, estradiol.cypionate, equol, erteberel",0.163675884293248,0.0931264652779296,FALSE +"HCC78","Pearson.est","estrogen receptor antagonist",0.28205,0.78,0.689,32,0.806,"tamoxifen",0.161780778092374,0.0936649581949093,FALSE +"HCC78","Pearson.est","FGFR inhibitor",-0.51804,-1.22,0.222,1376,0.482,"lucitanib, regorafenib",0.653647025549361,0.31695296176115,FALSE +"HCC78","Pearson.est","FLT3 inhibitor",-0.62176,-1.5,0.0595,1112,0.329,"gilteritinib, ponatinib, TG.101348, quizartinib, TG.02, ENMD.2076, tozasertib, KW.2449, sorafenib, pacritinib",1.22548303427145,0.482804102050026,FALSE +"HCC78","Pearson.est","glucocorticoid receptor agonist",0.62046,1.77,0.0303,129,0.305,"hydrocortisone, halcinonide, triamcinolone.acetonide, piretanide, dexamethasone.acetate, fluocinolone.acetonide, desonide",1.5185573714977,0.515700160653214,FALSE +"HCC78","Pearson.est","glutamate receptor antagonist",0.64484,1.76,0.0341,224,0.212,"latrepirdine, JNJ.16259685, kynurenic.acid, CPP, CGP.37849, felbamate, IEM1754",1.4672456210075,0.673664139071249,TRUE +"HCC78","Pearson.est","glycogen synthase kinase inhibitor",-0.23241,-0.546,0.958,878,1,"GSK.3.inhibitor.IX, LY2090314, indirubin, AZD2858, kenpaullone",0.0186344909214556,0,FALSE +"HCC78","Pearson.est","growth factor receptor inhibitor",-0.60838,-1.4,0.0955,1330,0.393,"PHA.848125, AZD3463, GSK1838705A",1.01999662841625,0.405607449624573,FALSE +"HCC78","Pearson.est","HCV inhibitor",-0.50399,-1.17,0.27,847,0.515,"mericitabine, embelin, Ro.9187, narlaprevir",0.568636235841013,0.288192770958809,FALSE +"HCC78","Pearson.est","HDAC inhibitor",-0.72749,-1.74,0.0124,1290,0.163,"SB.939, panobinostat, chidamide, PCI.24781, scriptaid, AR.42, givinostat, trichostatin.a, belinostat, dacinostat, M.344, vorinostat, R306465, RG2833, resminostat",1.90657831483776,0.787812395596042,TRUE +"HCC78","Pearson.est","histamine receptor antagonist",-0.25317,-0.594,0.941,1018,1,"levocetirizine, nizatidine, BF2.649, terfenadine, cyproheptadine, tiotidine",0.0264103765727431,0,FALSE +"HCC78","Pearson.est","HMGCR inhibitor",0.82927,2.38,0,64,0.0128,"pitavastatin, fluvastatin, mevastatin, atorvastatin",Inf,1.89279003035213,TRUE +"HCC78","Pearson.est","HSP inhibitor",-0.2995,-0.702,0.836,806,0.934,"SNX.5422, PU.H71, alvespimycin, XL888, ganetespib, NVP.AUY922, tanespimycin",0.0777937225609836,0.0296531237699066,FALSE +"HCC78","Pearson.est","JAK inhibitor",-0.56327,-1.33,0.139,1289,0.426,"PRT062070, TG.101209, TG.02, tozasertib, AT.9283, pacritinib",0.856985199745905,0.370590400897281,FALSE +"HCC78","Pearson.est","KIT inhibitor",-0.49064,-1.16,0.295,1039,0.49,"tandutinib, masitinib, telatinib, imatinib, pazopanib, KI.8751, regorafenib, sorafenib",0.530177984021837,0.309803919971486,FALSE +"HCC78","Pearson.est","MDM inhibitor",0.44437,1.26,0.185,200,0.38,"AMG.232, idasanutlin, CGM097, nutlin.3",0.732828271596986,0.42021640338319,FALSE +"HCC78","Pearson.est","MEK inhibitor",-0.31735,-0.748,0.804,754,0.912,"selumetinib, PD.184352, AZD8330, MEK162, refametinib, cobimetinib, trametinib, BIX.02188, arctigenin, nobiletin",0.0947439512515487,0.0400051616715838,FALSE +"HCC78","Pearson.est","MET inhibitor",-0.40467,-0.953,0.536,951,0.715,"INC.280, AMG458, LY2801653",0.27083521030723,0.145693958198919,FALSE +"HCC78","Pearson.est","microtubule inhibitor",-0.45716,-1.07,0.389,778,0.562,"cytochalasin.b, colchicine, podophyllotoxin, vinflunine, cabazitaxel, D.64131",0.410050398674292,0.250263684430939,FALSE +"HCC78","Pearson.est","mTOR inhibitor",-0.46778,-1.11,0.334,927,0.528,"temsirolimus, palomid.529, everolimus, LY303511, SB.2343, LY3023414, AZD8055, XL388, NVP.BEZ235, WYE.125132, WYE.354, GDC.0980, GSK2126458, AZD2014, torin.2, MLN0128",0.476253533188435,0.277366077466188,FALSE +"HCC78","Pearson.est","NFkB pathway inhibitor",-0.54161,-1.28,0.159,1202,0.415,"Ro.106.9920, EVP4593, bortezomib, betulinic.acid",0.798602875679548,0.381951903287907,FALSE +"HCC78","Pearson.est","opioid receptor agonist",0.52165,1.51,0.0579,138,0.318,"BW.180C, cebranopadol, spiradoline, ADL5859",1.23732143627256,0.497572880015567,FALSE +"HCC78","Pearson.est","p38 MAPK inhibitor",-0.5539,-1.31,0.145,1054,0.426,"SB.242235, SB.239063, talmapimod",0.838631997765025,0.370590400897281,FALSE +"HCC78","Pearson.est","PARP inhibitor",-0.624,-1.47,0.0508,1226,0.36,"niraparib, E7449, olaparib, talazoparib",1.29413628771608,0.443697499232713,FALSE +"HCC78","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.52414,-1.23,0.202,1039,0.478,"tandutinib, masitinib, trapidil, telatinib, ponatinib, imatinib, CP.673451, pazopanib, KI.8751, crenolanib, regorafenib, sorafenib",0.694648630553376,0.320572103387881,FALSE +"HCC78","Pearson.est","phosphatase inhibitor",-0.31824,-0.734,0.821,1106,0.913,"mycophenolic.acid, CID.5458317, GSK2830371",0.0856568428805592,0.039529222465701,FALSE +"HCC78","Pearson.est","phosphodiesterase inhibitor",0.35605,1.01,0.403,936,0.583,"EMD.53998, anagrelide, zardaverine, avanafil, cilostamide, papaverine, GSK256066, trequinsin, enoximone, YM.976",0.39469495385889,0.234331445240986,FALSE +"HCC78","Pearson.est","PI3K inhibitor",-0.38458,-0.909,0.603,715,0.747,"voxtalisib, PKI.179, GDC.0941, taselisib, TG100.115, YM.201636, ZSTK.474, PF.04691502, buparlisib, LY303511, SB.2343, LY3023414, TG.100713, BGT226, alpelisib, NVP.BEZ235, CUDC.907, CH5132799, GDC.0980, GSK2126458, PIK.75, PI3K.IN.2",0.219682687859849,0.126679398184601,FALSE +"HCC78","Pearson.est","PLK inhibitor",-0.75212,-1.78,0.0086,1098,0.161,"NMS.1286937, rigosertib, GSK461364, GW.843682X, BI.2536, volasertib",2.06550154875643,0.79317412396815,TRUE +"HCC78","Pearson.est","potassium channel blocker",-0.39447,-0.93,0.569,1117,0.74,"oleoylethanolamide, ML133",0.244887733604929,0.130768280269024,FALSE +"HCC78","Pearson.est","PPAR receptor agonist",0.25778,0.737,0.802,365,0.824,"clofibrate, fenofibrate, ciprofibrate, GW.501516",0.0958256317158365,0.0840727883028842,FALSE +"HCC78","Pearson.est","progesterone receptor agonist",-0.33901,-0.791,0.743,1096,0.871,"nomegestrol.acetate, melengestrol.acetate, dienogest",0.129011186239425,0.0599818449923368,FALSE +"HCC78","Pearson.est","proteasome inhibitor",-0.34502,-0.824,0.693,1353,0.854,"bortezomib",0.159266765388193,0.068542129310995,FALSE +"HCC78","Pearson.est","protein synthesis inhibitor",-0.24646,-0.577,0.947,820,1,"bruceantin, tedizolid.phosphate, homoharringtonine, florfenicol, azomycin..2.nitroimidazole., emetine, mercaptopurine, anguidine, thiostrepton",0.0236500209967266,0,FALSE +"HCC78","Pearson.est","protein tyrosine kinase inhibitor",-0.51701,-1.21,0.243,1343,0.485,"tyrphostin.A9, NVP.TAE226",0.614393726401688,0.314258261397736,FALSE +"HCC78","Pearson.est","RAF inhibitor",-0.54526,-1.29,0.187,1316,0.429,"TAK.632, RAF265, regorafenib, sorafenib",0.728158393463501,0.367542707815276,FALSE +"HCC78","Pearson.est","RET tyrosine kinase inhibitor",-0.71544,-1.68,0.0121,1154,0.17,"vandetanib, cabozantinib, regorafenib, sorafenib",1.91721462968355,0.769551078621726,TRUE +"HCC78","Pearson.est","retinoid receptor agonist",-0.49695,-1.19,0.252,1057,0.508,"bexarotene, CD.437, adarotene, fenretinide",0.598599459218456,0.294136287716081,FALSE +"HCC78","Pearson.est","ribonucleotide reductase inhibitor",-0.4069,-0.962,0.521,644,0.729,"hydroxyurea, gemcitabine, LY2334737, fludarabine.phosphate, pentostatin, cladribine, fludarabine, clofarabine",0.283162276700476,0.137272471682025,FALSE +"HCC78","Pearson.est","serotonin receptor agonist",0.36893,1.05,0.435,916,0.56,"NAN.190, SR.57227A, pardoprunox, ipsapirone, zolmitriptan, aripiprazole",0.361510743045363,0.2518119729938,FALSE +"HCC78","Pearson.est","serotonin receptor antagonist",-0.4249,-0.993,0.477,832,0.687,"lurasidone, aripiprazole, tropisetron, RS.16566, SB.216641, paliperidone, SB.228357, sertindole",0.321481620959886,0.16304326294045,FALSE +"HCC78","Pearson.est","sodium channel blocker",-0.48848,-1.16,0.289,1090,0.49,"triamterene, quinidine, butamben, lappaconite, ajmaline",0.539102157243452,0.309803919971486,FALSE +"HCC78","Pearson.est","src inhibitor",-0.34754,-0.825,0.722,894,0.869,"PP.2, PP.1, masitinib, bosutinib, KX2.391",0.141462802430361,0.0609802235513335,FALSE +"HCC78","Pearson.est","sterol demethylase inhibitor",0.51504,1.48,0.0829,428,0.299,"lanoconazole, posaconazole, sulconazole, terconazole, ketoconazole",1.08144546944973,0.52432881167557,FALSE +"HCC78","Pearson.est","TGF beta receptor inhibitor",0.37309,1.07,0.343,910,0.571,"SB.525334, repsox, LY2109761, adaprev, SB.431542, D.4476",0.464705879957229,0.243363891754152,FALSE +"HCC78","Pearson.est","thymidylate synthase inhibitor",-0.69991,-1.63,0.00846,1168,0.186,"carmofur, doxifluridine, trifluridine, raltitrexed",2.07262963696098,0.730487055782084,TRUE +"HCC78","Pearson.est","topoisomerase inhibitor",-0.6301,-1.46,0.0634,1066,0.324,"fleroxacin, amonafide, idarubicin, daunorubicin, beta.lapachone, SN.38, etoposide, licochalcone.a, topotecan, camptothecin, TAS.103, irinotecan, rubitecan, genz.644282, exatecan.mesylate",1.19791074211827,0.489454989793388,FALSE +"HCC78","Pearson.est","tubulin polymerization inhibitor",-0.39883,-0.953,0.537,680,0.715,"dolastatin.10, verubulin, plinabulin, oxibendazole, vinorelbine, ABT.751, BNC105, epothilone.d, parbendazole, nocodazole, podophyllotoxin, epothilone.b, combretastatin.A.4, flubendazole, KX2.391, taltobulin, paclitaxel, docetaxel, albendazole, fosbretabulin",0.270025714300444,0.145693958198919,FALSE +"HCC78","Pearson.est","tyrosine kinase inhibitor",-0.58889,-1.39,0.102,1154,0.366,"vandetanib, UNC2250, cabozantinib, aminopurvalanol.a, bafetinib, tyrphostin.A9, hypericin, tivantinib, regorafenib, sorafenib, NVP.TAE226",0.991399828238082,0.436518914605589,FALSE +"HCC78","Pearson.est","VEGFR inhibitor",-0.46323,-1.07,0.39,1362,0.562,"ENMD.2076, KI.8751, lucitanib, RAF265, golvatinib, regorafenib, sorafenib, foretinib",0.408935392973501,0.250263684430939,FALSE +"HCC78","Pearson.est","vitamin D receptor agonist",-0.5406,-1.28,0.167,779,0.415,"calcitriol, alfacalcidol, paricalcitol, doxercalciferol, ercalcitriol, maxacalcitol, tacalcitol",0.777283528852417,0.381951903287907,FALSE +"H2126","Pearson.est","EGFR inhibitor",0.2442,0.593,0.902,149,0.96,"salvianolic.acid.B, CUDC.101, dovitinib, WZ.4002",0.0447934624580583,0.0177287669604316,FALSE +"H2126","Pearson.est","Abl kinase inhibitor",0.50265,1.24,0.225,463,0.449,"bafetinib, ponatinib, tozasertib, imatinib, metatinib, nilotinib, KW.2449, flumatinib, GZD824",0.647817481888638,0.347753658996677,FALSE +"H2126","Pearson.est","acetylcholine receptor agonist",-0.38343,-1.02,0.376,1171,0.613,"xanomeline, tremorine, nicotine",0.424812155072339,0.212539525481585,FALSE +"H2126","Pearson.est","acetylcholine receptor antagonist",-0.35922,-0.967,0.455,518,0.601,"methscopolamine, diphemanil, iododexetimide, darifenacin, dicycloverine, hyoscyamine",0.341988603342888,0.22112552799726,FALSE +"H2126","Pearson.est","adenosine receptor antagonist",0.69637,1.67,0.022,298,0.341,"CGS.15943, MRS.1220",1.65757731917779,0.467245621007502,FALSE +"H2126","Pearson.est","adrenergic receptor agonist",0.26443,0.645,0.889,195,0.932,"buphenine, clenbuterol, metaraminol",0.0510982390297863,0.0305840876460186,FALSE +"H2126","Pearson.est","adrenergic receptor antagonist",0.21945,0.534,0.956,462,0.962,"practolol, atipamezole, atenolol......, prazosin, pindolol, carvedilol, vincamine",0.0195421077238999,0.0168249279621871,FALSE +"H2126","Pearson.est","AKT inhibitor",0.59946,1.49,0.0679,239,0.346,"uprosertib, GDC.0068, A.674563, ONC201, GSK2110183, MK.2206",1.1681302257195,0.460923901207223,FALSE +"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.46904,1.16,0.282,284,0.5,"crizotinib, DMH1, alectinib, CEP.37440, AZD3463, lorlatinib",0.549750891680639,0.301029995663981,FALSE +"H2126","Pearson.est","androgen receptor antagonist",-0.46117,-1.26,0.201,665,0.519,"nilutamide, flutamide, enzalutamide, bicalutamide, cyproterone.acetate, RU.58841",0.696803942579511,0.284832642151542,FALSE +"H2126","Pearson.est","antioxidant",-0.4466,-1.23,0.195,644,0.472,"trolox, taurine, benfotiamine, chlorogenic.acid, mesna, rutin",0.709965388637482,0.326058001365912,FALSE +"H2126","Pearson.est","AP inhibitor",-0.79753,-2.13,0,1194,0.0344,"idronoxil, tanshinone.i, birinapant, GDC.0152, LCL.161",Inf,1.46344155742847,TRUE +"H2126","Pearson.est","ATPase inhibitor",0.40611,0.993,0.467,120,0.648,"evodiamine, digoxin, blebbistatin....",0.330683119433888,0.188424994129407,FALSE +"H2126","Pearson.est","Aurora kinase inhibitor",0.58465,1.41,0.0962,368,0.389,"barasertib, CCT137690, AT.9283, tozasertib, CCT129202, aurora.a.inhibitor.i, SNS.314, AMG900, barasertib.HQPA, ZM.447439, alisertib, KW.2449, TAK.901",1.01682492796219,0.410050398674292,FALSE +"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.27591,0.681,0.861,107,0.911,"valnemulin",0.0649968485463452,0.0404816230270017,FALSE +"H2126","Pearson.est","bacterial DNA gyrase inhibitor",-0.42949,-1.18,0.26,1000,0.471,"sarafloxacin, sparfloxacin, norfloxacin, finafloxacin, lomefloxacin, trovafloxacin",0.585026652029182,0.326979092871104,FALSE +"H2126","Pearson.est","BCL inhibitor",0.52578,1.28,0.209,479,0.471,"ABT.737, venetoclax, HA14.1, oridonin, TW.37, navitoclax, gossypol",0.679853713888946,0.326979092871104,FALSE +"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.57644,1.43,0.103,288,0.381,"bafetinib, ponatinib, tozasertib, imatinib, metatinib, nilotinib",0.987162775294828,0.419075024324381,FALSE +"H2126","Pearson.est","benzodiazepine receptor agonist",0.30329,0.739,0.758,468,0.875,"ZK.93423, bentazepam, piperazine, temazepam, ivermectin, nefiracetam",0.120330794367946,0.0579919469776868,FALSE +"H2126","Pearson.est","bromodomain inhibitor",0.65326,1.61,0.0419,506,0.29,"JQ1...., I.BET151, OTX015, I.BET.762, bromosporine, PFI.1",1.3777859770337,0.537602002101044,FALSE +"H2126","Pearson.est","calcium channel blocker",0.6198,1.51,0.0723,106,0.339,"carboxyamidotriazole, pranidipine, cinnarazine, penfluridol",1.14086170270547,0.469800301796918,FALSE +"H2126","Pearson.est","CC chemokine receptor antagonist",0.45458,1.1,0.353,373,0.52,"ZK811752, PF.04136309, SB.225002, RS.504393",0.452225294612177,0.283996656365201,FALSE +"H2126","Pearson.est","CDK inhibitor",0.59471,1.46,0.0855,265,0.349,"abemaciclib, indisulam, palbociclib, ribociclib, JNJ.7706621, dinaciclib, arcyriaflavin.a, TG.02, PHA.848125, AZD5438",1.06803388527183,0.45717457304082,FALSE +"H2126","Pearson.est","CHK inhibitor",-0.64019,-1.72,0.0274,1162,0.257,"CHIR.124, PF.477736, LY2606368, SCH.900776, AZD7762",1.56224943717961,0.590066876668705,FALSE +"H2126","Pearson.est","cyclooxygenase inhibitor",-0.2577,-0.705,0.778,1239,0.848,"acetylsalicylsalicylic.acid, tryptanthrin, FK.3311, metoxibutropate, amfenac, sulfasalazine, AM.404",0.109020403010311,0.0716041477432862,FALSE +"H2126","Pearson.est","cytochrome P450 inhibitor",-0.56726,-1.55,0.0807,1234,0.396,"clotrimazole, PF.4981517, eplerenone",1.09312646527793,0.402304814074488,FALSE +"H2126","Pearson.est","DNA alkylating agent",0.43049,1.05,0.407,366,0.587,"estramustine, mitomycin.c, TH.302, melphalan, ifosfamide, cisplatin",0.39040559077478,0.231361898752386,FALSE +"H2126","Pearson.est","DNA inhibitor",0.33894,0.835,0.664,417,0.787,"melphalan, chlorambucil, oxaliplatin, pibenzimol, metronidazole, nithiamide, mechlorethamine",0.177831920631982,0.104025267640935,FALSE +"H2126","Pearson.est","DNA methyltransferase inhibitor",0.53275,1.31,0.138,152,0.46,"fdcyd, SGI.1027",0.860120913598763,0.337242168318426,FALSE +"H2126","Pearson.est","DNA polymerase inhibitor",0.31019,0.776,0.722,297,0.841,"trifluridine, idoxuridine",0.141462802430361,0.0752040042020878,FALSE +"H2126","Pearson.est","DNA synthesis inhibitor",0.37633,0.926,0.557,366,0.693,"artesunate, mitomycin.c, enocitabine, cyclocytidine, anisomycin, cisplatin",0.254144804826271,0.159266765388193,FALSE +"H2126","Pearson.est","dopamine receptor antagonist",-0.30815,-0.836,0.654,1319,0.787,"ziprasidone, thioproperazine, raclopride, remoxipride",0.184422251675733,0.104025267640935,FALSE +"H2126","Pearson.est","estrogen receptor agonist",-0.44758,-1.21,0.222,1107,0.464,"PPT, estradiol.cypionate, erteberel, ethinyl.estradiol, levonorgestrel",0.653647025549361,0.333482019445119,FALSE +"H2126","Pearson.est","estrogen receptor antagonist",-0.45103,-1.25,0.219,1339,0.485,"tamoxifen, raloxifene",0.659555885159882,0.314258261397736,FALSE +"H2126","Pearson.est","FGFR inhibitor",0.5063,1.24,0.223,188,0.449,"regorafenib, erdafitinib, dovitinib, PD.173074",0.651695136951839,0.347753658996677,FALSE +"H2126","Pearson.est","FLT3 inhibitor",0.66465,1.62,0.0286,220,0.313,"sorafenib, quizartinib, pacritinib, TG.101348, ponatinib, tozasertib, dovitinib, TG.02, sunitinib",1.54363396687096,0.504455662453552,FALSE +"H2126","Pearson.est","glucocorticoid receptor agonist",-0.47278,-1.26,0.215,1078,0.519,"triamcinolone, fludroxycortide, fluocinolone.acetonide, halcinonide, difluprednate, piretanide, ciclesonide, triamcinolone.acetonide, fluorometholone, prednisolone.acetate, dexamethasone.acetate, hydrocortisone",0.667561540084395,0.284832642151542,FALSE +"H2126","Pearson.est","glutamate receptor antagonist",-0.49062,-1.34,0.129,1139,0.575,"LY456236, MTPG, kynurenic.acid, IEM1754, CGP.37849, latrepirdine, JNJ.16259685",0.889410289700751,0.24033215531037,FALSE +"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.29912,-0.81,0.672,1160,0.793,"CHIR.98014, CHIR.99021, tideglusib",0.172630726946175,0.100726812682396,FALSE +"H2126","Pearson.est","growth factor receptor inhibitor",0.46259,1.13,0.31,648,0.501,"PHA.848125, AZD3463, GW.441756, GSK1838705A, danusertib, lestaurtinib",0.508638306165727,0.300162274132754,FALSE +"H2126","Pearson.est","HCV inhibitor",-0.36224,-0.967,0.461,1332,0.601,"narlaprevir",0.336299074610352,0.22112552799726,FALSE +"H2126","Pearson.est","HDAC inhibitor",0.56432,1.38,0.126,207,0.4,"belinostat, vorinostat, RGFP966, resminostat, R306465, M.344, chidamide, scriptaid, givinostat, RG2833, panobinostat",0.899629454882437,0.397940008672038,FALSE +"H2126","Pearson.est","histamine receptor antagonist",-0.29654,-0.787,0.755,1231,0.762,"ranitidine, ebastine, astemizole, zolantidine",0.122053048370812,0.1180450286604,FALSE +"H2126","Pearson.est","HMGCR inhibitor",-0.74594,-2,0.0162,1133,0.0721,"atorvastatin, lovastatin, mevastatin, fluvastatin, pitavastatin",1.79048498545737,1.14206473528057,TRUE +"H2126","Pearson.est","HSP inhibitor",0.34151,0.841,0.651,447,0.812,"NMS.E973, SNX.5422, NVP.AUY922, tanespimycin",0.186419011431808,0.0904439707588247,FALSE +"H2126","Pearson.est","JAK inhibitor",0.53474,1.33,0.172,172,0.447,"pacritinib, TG.101348, AT.9283, tozasertib, AZ960, TG.02",0.764471553092451,0.349692476868064,FALSE +"H2126","Pearson.est","KIT inhibitor",0.66938,1.64,0.0241,121,0.331,"sorafenib, pazopanib, regorafenib, motesanib, masitinib, imatinib, KI.8751",1.61798295742513,0.480172006224281,FALSE +"H2126","Pearson.est","MDM inhibitor",0.47402,1.15,0.307,271,0.486,"serdemetan, nutlin.3",0.512861624522813,0.313363730737707,FALSE +"H2126","Pearson.est","MEK inhibitor",-0.43064,-1.16,0.266,1050,0.467,"AZD8330, AS.703026, cobimetinib, MEK162, PD.198306, MEK1.2.inhibitor, PD.318088, U.0126, PD.184352, TAK.733, Ro.4987655",0.575118363368933,0.330683119433888,FALSE +"H2126","Pearson.est","MET inhibitor",0.48978,1.2,0.253,54,0.482,"AMG458",0.596879478824182,0.31695296176115,FALSE +"H2126","Pearson.est","microtubule inhibitor",0.34255,0.836,0.67,575,0.802,"vinflunine, D.64131, vinblastine, triclabendazole, cabazitaxel, podophyllotoxin",0.173925197299174,0.0958256317158365,FALSE +"H2126","Pearson.est","mTOR inhibitor",0.52639,1.26,0.201,359,0.467,"WYE.125132, AZD2014, torin.2, everolimus, MLN0128, temsirolimus, PF.05212384, PI.103, NVP.BEZ235, PP242, WYE.354, GSK2126458, SB.2343, LY3023414",0.696803942579511,0.330683119433888,FALSE +"H2126","Pearson.est","NFkB pathway inhibitor",0.4181,1.03,0.442,422,0.605,"EVP4593, bortezomib, betulinic.acid, Ro.106.9920, curcumin, BAY.11.7082, bindarit",0.354577730650908,0.218244625347531,FALSE +"H2126","Pearson.est","opioid receptor agonist",-0.76517,-2.14,0.00625,1393,0.063,"cebranopadol, ADL5859, BW.180C",2.20411998265592,1.20065945054642,TRUE +"H2126","Pearson.est","p38 MAPK inhibitor",0.46106,1.1,0.349,307,0.52,"skepinone.l, SB.239063",0.45717457304082,0.283996656365201,FALSE +"H2126","Pearson.est","PARP inhibitor",0.60099,1.48,0.0735,338,0.338,"niraparib, talazoparib, PJ.34, olaparib, AG.14361",1.1337126609158,0.471083299722345,FALSE +"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.65411,1.6,0.0514,121,0.269,"sorafenib, pazopanib, regorafenib, motesanib, masitinib, axitinib, ponatinib, imatinib, dovitinib, KI.8751",1.28903688100472,0.570247719997592,FALSE +"H2126","Pearson.est","phosphatase inhibitor",0.31797,0.795,0.725,206,0.829,"GSK2830371, alexidine",0.139661993429006,0.0814454694497265,FALSE +"H2126","Pearson.est","phosphodiesterase inhibitor",-0.22641,-0.613,0.91,1269,0.915,"YM.976, papaverine",0.0409586076789064,0.0385789059335517,FALSE +"H2126","Pearson.est","PI3K inhibitor",0.47058,1.15,0.31,414,0.486,"buparlisib, CH5132799, YM.201636, PF.05212384, PI.103, NVP.BEZ235, PIK.75, CUDC.907, GSK2126458, SB.2343, LY3023414, TG100.115, PI3K.IN.2, BGT226",0.508638306165727,0.313363730737707,FALSE +"H2126","Pearson.est","PLK inhibitor",0.74462,1.83,0.00577,375,0.19,"GW.843682X, volasertib, rigosertib, GSK461364, NMS.1286937, BI.2536, HMN.214",2.23882418684427,0.721246399047171,TRUE +"H2126","Pearson.est","potassium channel blocker",-0.57127,-1.53,0.0939,1435,0.355,"meglitinide",1.02733440773389,0.449771646944906,FALSE +"H2126","Pearson.est","PPAR receptor agonist",-0.36849,-0.969,0.489,531,0.663,"S26948, GW.501516, pterostilbene, ciprofibrate, oleoylethanolamide, fenofibrate, clofibrate",0.31069114087638,0.178486471595227,FALSE +"H2126","Pearson.est","progesterone receptor agonist",-0.40242,-1.13,0.299,1176,0.476,"danazol, dienogest, norethindrone.acetate, levonorgestrel",0.52432881167557,0.322393047279507,FALSE +"H2126","Pearson.est","proteasome inhibitor",0.49276,1.2,0.246,632,0.482,"carfilzomib, bortezomib, MG.132, oprozomib, ixazomib, delanzomib",0.609064892896621,0.31695296176115,FALSE +"H2126","Pearson.est","protein synthesis inhibitor",0.50738,1.25,0.209,341,0.466,"azomycin..2.nitroimidazole., florfenicol, mercaptopurine, thiostrepton, anguidine, homoharringtonine, tedizolid.phosphate, harringtonine",0.679853713888946,0.33161408331,FALSE +"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.28694,-0.798,0.685,1203,0.778,"rheochrysidin, PP.121, AV.412",0.164309428507574,0.109020403010311,FALSE +"H2126","Pearson.est","RAF inhibitor",0.48647,1.16,0.291,388,0.5,"sorafenib, regorafenib, RAF265, TAK.632, PLX.4720, SB.590885",0.536107011014093,0.301029995663981,FALSE +"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.73486,1.8,0.00587,220,0.163,"sorafenib, regorafenib, cabozantinib, sunitinib",2.23136189875239,0.787812395596042,TRUE +"H2126","Pearson.est","retinoid receptor agonist",0.76113,1.83,0.00592,235,0.19,"fenretinide, adarotene, adapalene, bexarotene, AM.580, tamibarotene, CD.437",2.22767829327708,0.721246399047171,TRUE +"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.40058,0.989,0.443,661,0.639,"cytarabine, LY2334737, pentostatin, fludarabine, fludarabine.phosphate",0.35359627377693,0.1944991418416,FALSE +"H2126","Pearson.est","serotonin receptor agonist",0.40011,0.978,0.461,2,0.64,"aripiprazole",0.336299074610352,0.193820026016113,FALSE +"H2126","Pearson.est","serotonin receptor antagonist",0.61874,1.52,0.0647,90,0.391,"aripiprazole, sertindole, paliperidone, lurasidone",1.1890957193313,0.407823242604133,FALSE +"H2126","Pearson.est","sodium channel blocker",0.5133,1.27,0.206,275,0.469,"ajmaline, brivaracetam, butamben, quinidine, cibenzoline, triamterene",0.686132779630847,0.328827157284917,FALSE +"H2126","Pearson.est","src inhibitor",-0.48772,-1.31,0.19,1180,0.554,"TG.100572, bosutinib, PP.1, dasatinib, saracatinib, ZM.306416",0.721246399047171,0.25649023527157,FALSE +"H2126","Pearson.est","sterol demethylase inhibitor",0.28862,0.696,0.838,339,0.911,"chlormidazole, posaconazole",0.0767559813697235,0.0404816230270017,FALSE +"H2126","Pearson.est","TGF beta receptor inhibitor",0.23959,0.59,0.93,593,0.945,"adaprev, D.4476, SB.431542",0.0315170514460649,0.0245681914907371,FALSE +"H2126","Pearson.est","thymidylate synthase inhibitor",0.61883,1.51,0.0598,136,0.339,"raltitrexed, trifluridine",1.22329881601159,0.469800301796918,FALSE +"H2126","Pearson.est","topoisomerase inhibitor",0.53293,1.29,0.2,523,0.474,"topotecan, irinotecan, rubitecan, etoposide.phosphate, idarubicin, exatecan.mesylate, amonafide, epirubicin, genz.644282, camptothecin, daunorubicin, TAS.103, dexrazoxane, SN.38, doxorubicin, teniposide, nemorubicin",0.698970004336019,0.324221658325915,FALSE +"H2126","Pearson.est","tubulin polymerization inhibitor",0.48384,1.16,0.28,627,0.5,"albendazole, taltobulin, parbendazole, BNC105, docetaxel, vinorelbine, vindesine, flubendazole, vinblastine, indibulin, combretastatin.A.4, fosbretabulin, verubulin, oxibendazole, KX2.391, paclitaxel, plinabulin, podophyllotoxin, epothilone.d, epothilone.b, nocodazole, dolastatin.10, ABT.751",0.552841968657781,0.301029995663981,FALSE +"H2126","Pearson.est","tyrosine kinase inhibitor",0.40167,0.974,0.498,425,0.632,"bafetinib, sorafenib, regorafenib, cabozantinib, sunitinib, mubritinib, tivantinib, NVP.TAE226, apatinib, hypericin, tyrphostin.A9",0.302770657240282,0.199282921717615,FALSE +"H2126","Pearson.est","VEGFR inhibitor",0.57482,1.39,0.12,224,0.406,"sorafenib, foretinib, pazopanib, regorafenib, tivozanib, motesanib, axitinib, golvatinib, dovitinib, KI.8751, cabozantinib, PD.173074, sunitinib, RAF265",0.920818753952375,0.391473966422806,FALSE +"H2126","Pearson.est","vitamin D receptor agonist",0.54679,1.35,0.134,313,0.431,"calcitriol, tacalcitol, maxacalcitol",0.872895201635192,0.365522729839268,FALSE +"HCC827","Pearson.est","EGFR inhibitor",-0.59737,-1.5,0.0816,1170,0.61,"BIBU.1361, OSI.420, canertinib, CUDC.101, salvianolic.acid.B, afatinib, dacomitinib, PD.153035, AZD8931, erlotinib, BIBX.1382, brigatinib, tyrphostin.AG.1478, PD.168393, tyrphostin.AG.494, gefitinib, WZ8040, pelitinib, XL.647, GW.583340, neratinib, osimertinib, BMS.599626, vandetanib, icotinib",1.08830984124614,0.214670164989233,FALSE +"HCC827","Pearson.est","Abl kinase inhibitor",-0.49562,-1.28,0.204,1138,0.543,"tozasertib, nilotinib, flumatinib, KW.2449, bosutinib, dasatinib",0.690369832574101,0.265200170411153,FALSE +"HCC827","Pearson.est","acetylcholine receptor agonist",-0.61329,-1.57,0.0692,1358,0.534,"pilocarpine, nicotine",1.15989390554324,0.272458742971444,FALSE +"HCC827","Pearson.est","acetylcholine receptor antagonist",0.52196,1.35,0.146,216,0.542,"diphemanil, darifenacin, hyoscyamine",0.835647144215563,0.266000713461613,FALSE +"HCC827","Pearson.est","adenosine receptor antagonist",0.64976,1.68,0.0436,131,0.32,"MRS.1220, SCH.58261",1.36051351073141,0.494850021680094,FALSE +"HCC827","Pearson.est","adrenergic receptor agonist",-0.5427,-1.38,0.136,1351,0.524,"epinephrine, terbutaline, isoxsuprine, midodrine, A61603",0.866461091629782,0.280668713016273,FALSE +"HCC827","Pearson.est","adrenergic receptor antagonist",0.3345,0.856,0.598,262,0.887,"prazosin, practolol, atenolol...., propranolol, RS.17053",0.223298816011589,0.0520763801682736,FALSE +"HCC827","Pearson.est","AKT inhibitor",0.29387,0.774,0.71,238,0.891,"GDC.0068, GSK2110183, ONC201, uprosertib",0.148741651280925,0.0501222959631252,FALSE +"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.43379,-1.14,0.289,981,0.589,"alectinib, CEP.37440, GW.788388, lorlatinib, DMH1, AZD3463, brigatinib, AP26113",0.539102157243452,0.229884705212898,FALSE +"HCC827","Pearson.est","androgen receptor antagonist",-0.50807,-1.29,0.195,927,0.607,"bicalutamide, RU.58841, flutamide, nilutamide, enzalutamide",0.709965388637482,0.216811308924742,FALSE +"HCC827","Pearson.est","antioxidant",-0.4981,-1.28,0.215,1094,0.543,"taurine, trolox, mesna",0.667561540084395,0.265200170411153,FALSE +"HCC827","Pearson.est","AP inhibitor",0.3324,0.89,0.57,447,0.884,"birinapant, tanshinone.i, embelin",0.244125144327509,0.0535477349869269,FALSE +"HCC827","Pearson.est","ATPase inhibitor",0.4297,1.11,0.318,288,0.807,"oligomycin.a, NMS.873, evodiamine, digitoxigenin",0.497572880015567,0.0931264652779296,FALSE +"HCC827","Pearson.est","Aurora kinase inhibitor",0.29219,0.765,0.736,351,0.879,"PHA.680632, TAK.901, danusertib, CCT137690, CCT129202, barasertib, AT.9283",0.133122185662501,0.0560111249262281,FALSE +"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.58041,-1.49,0.11,1297,0.474,"tilmicosin, azithromycin, dirithromycin",0.958607314841775,0.324221658325915,FALSE +"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",0.4323,1.13,0.308,197,0.81,"norfloxacin, nadifloxacin, trovafloxacin",0.511449283499556,0.0915149811213502,FALSE +"HCC827","Pearson.est","BCL inhibitor",0.35366,0.93,0.52,103,0.947,"obatoclax",0.283996656365201,0.0236500209967266,FALSE +"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",-0.49342,-1.3,0.186,1138,0.635,"tozasertib, nilotinib, flumatinib, bosutinib, dasatinib",0.730487055782084,0.197226274708024,FALSE +"HCC827","Pearson.est","benzodiazepine receptor agonist",0.28097,0.738,0.756,284,0.895,"ZK.93423, gamma.aminobutyric.acid, zaleplon",0.121478204498793,0.048176964684088,FALSE +"HCC827","Pearson.est","bromodomain inhibitor",0.67659,1.77,0.0309,430,0.313,"I.BET151, I.BET.762, JQ1...., OTX015, bromosporine",1.51004152057517,0.504455662453552,FALSE +"HCC827","Pearson.est","calcium channel blocker",0.51014,1.32,0.169,372,0.553,"SR.33805, carboxyamidotriazole, pranidipine, mibefradil, efonidipine.monoethanolate",0.772113295386326,0.257274868695302,FALSE +"HCC827","Pearson.est","CC chemokine receptor antagonist",-0.40793,-1.05,0.388,1171,0.657,"MK.0812, PF.04136309, RS.504393, navarixin",0.411168274405793,0.182434630440219,FALSE +"HCC827","Pearson.est","CDK inhibitor",-0.3083,-0.801,0.696,1236,0.908,"AT.7519, BMS.265246, AZD5438, PHA.848125, aminopurvalanol.a, alvocidib",0.157390760389438,0.0419141514789149,FALSE +"HCC827","Pearson.est","CHK inhibitor",-0.75295,-1.99,0.00577,1135,0.144,"CHIR.124, LY2603618, SB.218078, AZD7762, SCH.900776, LY2606368",2.23882418684427,0.84163750790475,TRUE +"HCC827","Pearson.est","cyclooxygenase inhibitor",0.251,0.642,0.869,266,0.922,"AM.404, naproxen, ramifenazone, piroxicam, amfenac",0.0609802235513335,0.0352690789463706,FALSE +"HCC827","Pearson.est","cytochrome P450 inhibitor",-0.47419,-1.21,0.241,1199,0.593,"eplerenone, itraconazole",0.617982957425132,0.226945306635737,FALSE +"HCC827","Pearson.est","DNA alkylating agent",-0.35763,-0.923,0.532,1048,0.8,"ifosfamide, dacarbazine, estramustine, temozolomide, carboplatin, streptozotocin",0.274088367704952,0.0969100130080564,FALSE +"HCC827","Pearson.est","DNA inhibitor",0.25023,0.652,0.857,297,0.959,"teroxirone, valrubicin, chlorambucil, pibenzimol, bendamustine",0.0670191780768018,0.0181813928293364,FALSE +"HCC827","Pearson.est","DNA methyltransferase inhibitor",0.60006,1.56,0.0626,124,0.361,"fdcyd, SGI.1027, disulfiram",1.20342566678957,0.442492798094342,FALSE +"HCC827","Pearson.est","DNA polymerase inhibitor",-0.27764,-0.723,0.782,974,0.975,"adefovir.dipivoxil, foscarnet, idoxuridine",0.106793246940152,0.0109953843014632,FALSE +"HCC827","Pearson.est","DNA synthesis inhibitor",-0.14241,-0.363,0.998,1377,0.999,"capecitabine",0.000869458712628891,0.000434511774017692,FALSE +"HCC827","Pearson.est","dopamine receptor antagonist",-0.30409,-0.79,0.716,1047,0.898,"sertindole, isofloxythepin, remoxipride, UH.232...., raclopride, piperacetazine, acetophenazine",0.145086977692144,0.0467236633326956,FALSE +"HCC827","Pearson.est","estrogen receptor agonist",-0.44525,-1.16,0.3,1299,0.584,"estradiol.cypionate, estradiol",0.522878745280338,0.233587152887601,FALSE +"HCC827","Pearson.est","estrogen receptor antagonist",-0.33773,-0.883,0.553,487,0.817,"raloxifene, fulvestrant, clomifene, toremifene, tamoxifen, danazol",0.257274868695302,0.0877779434675845,FALSE +"HCC827","Pearson.est","FGFR inhibitor",0.60546,1.58,0.057,253,0.377,"dovitinib, PD.173074, lenvatinib, erdafitinib, AZD4547, nintedanib",1.24412514432751,0.423658649794207,FALSE +"HCC827","Pearson.est","FLT3 inhibitor",0.34014,0.863,0.598,49,0.905,"dovitinib, quizartinib, GTP.14564",0.223298816011589,0.0433514207947967,FALSE +"HCC827","Pearson.est","glucocorticoid receptor agonist",-0.36645,-0.924,0.521,959,0.829,"desonide, clobetasol.propionate, triamcinolone, fludroxycortide, dexamethasone.acetate, ciclesonide, prednisolone.acetate, prednisolone.hemisuccinate, beclomethasone.dipropionate, flumethasone.pivalate, flumethasone, fluorometholone, fluocinolone.acetonide",0.283162276700476,0.0814454694497265,FALSE +"HCC827","Pearson.est","glutamate receptor antagonist",0.44688,1.17,0.306,247,0.828,"ACDPP, kynurenic.acid, felbamate, IEM1754, CGP.37849",0.51427857351842,0.0819696632151199,FALSE +"HCC827","Pearson.est","glycogen synthase kinase inhibitor",-0.22717,-0.589,0.923,1020,0.973,"GSK.3.inhibitor.IX, CHIR.98014, kenpaullone, LY2090314",0.0347982989740879,0.0118871597316481,FALSE +"HCC827","Pearson.est","growth factor receptor inhibitor",-0.53767,-1.39,0.129,1237,0.556,"AZD3463, GSK1904529A, GSK1838705A, PHA.848125",0.889410289700751,0.254925208417942,FALSE +"HCC827","Pearson.est","HCV inhibitor",-0.46065,-1.19,0.283,1415,0.562,"narlaprevir",0.54821356447571,0.250263684430939,FALSE +"HCC827","Pearson.est","HDAC inhibitor",-0.3447,-0.892,0.582,1011,0.829,"JNJ.26481585, vorinostat, romidepsin, resminostat, chidamide, PCI.24781, AR.42, belinostat, dacinostat, trichostatin.a, panobinostat, RG2833, mocetinostat",0.235077015350112,0.0814454694497265,FALSE +"HCC827","Pearson.est","histamine receptor antagonist",-0.24671,-0.641,0.892,1010,0.976,"cimetidine, terfenadine, nizatidine, tiotidine, pheniramine, cyproheptadine, famotidine",0.0496351456238769,0.0105501823333082,FALSE +"HCC827","Pearson.est","HMGCR inhibitor",0.40361,1.04,0.386,866,0.829,"atorvastatin, lovastatin, pitavastatin, mevastatin, fluvastatin, simvastatin",0.413412695328245,0.0814454694497265,FALSE +"HCC827","Pearson.est","HSP inhibitor",0.58742,1.54,0.0755,434,0.349,"NMS.E973, BIIB021, XL888, SNX.2112, VER.49009, alvespimycin, NVP.AUY922, tanespimycin, KW.2478, SNX.5422, guanidine",1.12205304837081,0.45717457304082,FALSE +"HCC827","Pearson.est","JAK inhibitor",-0.2258,-0.58,0.934,1120,0.956,"filgotinib, tozasertib, TG.101209, pacritinib, CEP.33779",0.0296531237699066,0.0195421077238999,FALSE +"HCC827","Pearson.est","KIT inhibitor",0.24638,0.643,0.892,182,0.944,"lenvatinib, imatinib, pazopanib, motesanib",0.0496351456238769,0.025028005701931,FALSE +"HCC827","Pearson.est","MDM inhibitor",0.78617,2.04,0.00395,95,0.11,"AMG.232, idasanutlin, nutlin.3, CGM097",2.40340290437354,0.958607314841775,TRUE +"HCC827","Pearson.est","MEK inhibitor",-0.75641,-1.92,0.00378,1240,0.143,"PD.318088, PD.0325901, BIX.02188, TAK.733, Ro.4987655, AS.703026, MEK162, selumetinib, AZD8330, nobiletin, refametinib, PD.184352, cobimetinib, trametinib",2.42250820016277,0.844663962534938,TRUE +"HCC827","Pearson.est","MET inhibitor",-0.62207,-1.63,0.0494,1038,0.492,"NVP.BVU972, PF.04217903, PHA.665752, LY2801653",1.30627305107635,0.30803489723264,FALSE +"HCC827","Pearson.est","microtubule inhibitor",0.19727,0.533,0.97,77,0.987,"triclabendazole",0.0132282657337552,0.00568284733036327,FALSE +"HCC827","Pearson.est","mTOR inhibitor",0.57691,1.47,0.0971,302,0.42,"sirolimus, PF.05212384, PKI.179, WYE.125132, OSI.027, PI.103, torin.1, deforolimus, everolimus, PP242, temsirolimus, XL388, torin.2, AZD8055, ku.0063794, voxtalisib",1.012780770092,0.3767507096021,FALSE +"HCC827","Pearson.est","NFkB pathway inhibitor",0.34512,0.907,0.543,180,0.918,"EVP4593, parthenolide...., BAY.11.7082",0.265200170411153,0.0371573187987575,FALSE +"HCC827","Pearson.est","opioid receptor agonist",-0.23064,-0.593,0.909,1118,0.995,"BW.180C, trimebutine",0.0414361167780325,0.00217691925427455,FALSE +"HCC827","Pearson.est","p38 MAPK inhibitor",0.26913,0.703,0.821,92,0.919,"skepinone.l",0.0856568428805592,0.0366844886138887,FALSE +"HCC827","Pearson.est","PARP inhibitor",0.60925,1.61,0.0556,319,0.381,"niraparib, PJ.34, AZD2461, talazoparib, AG.14361",1.25492520841794,0.419075024324381,FALSE +"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.37573,0.992,0.416,295,0.892,"dovitinib, lenvatinib, linifanib, imatinib, trapidil, pazopanib, motesanib, axitinib, nintedanib, sunitinib",0.380906669373257,0.0496351456238769,FALSE +"HCC827","Pearson.est","phosphatase inhibitor",0.35765,0.92,0.524,28,0.928,"mycophenolate.mofetil",0.280668713016273,0.0324520237811379,FALSE +"HCC827","Pearson.est","phosphodiesterase inhibitor",-0.28225,-0.714,0.795,1417,0.961,"YM.976",0.0996328713435297,0.0172766123314547,FALSE +"HCC827","Pearson.est","PI3K inhibitor",0.35056,0.904,0.557,302,0.888,"PF.05212384, PKI.179, PI.103, PI.828, BGT226, buparlisib, idelalisib, voxtalisib",0.254144804826271,0.051587034221399,FALSE +"HCC827","Pearson.est","PLK inhibitor",0.31442,0.813,0.697,532,0.88,"HMN.214, rigosertib, GSK461364, NMS.1286937, GW.843682X",0.156767221901991,0.0555173278498314,FALSE +"HCC827","Pearson.est","potassium channel blocker",-0.47438,-1.26,0.2,1368,0.54,"oleoylethanolamide, meglitinide",0.698970004336019,0.267606240177031,FALSE +"HCC827","Pearson.est","PPAR receptor agonist",0.31971,0.847,0.609,173,0.874,"ciprofibrate, clofibrate",0.215382707367125,0.058488567365597,FALSE +"HCC827","Pearson.est","progesterone receptor agonist",-0.24861,-0.65,0.865,930,1,"nomegestrol.acetate, norethindrone.acetate, danazol, levonorgestrel, melengestrol.acetate, dienogest",0.0629838925351858,0,FALSE +"HCC827","Pearson.est","proteasome inhibitor",-0.24627,-0.641,0.862,1212,0.976,"bortezomib, ixazomib",0.0644927341752872,0.0105501823333082,FALSE +"HCC827","Pearson.est","protein synthesis inhibitor",0.71363,1.86,0.0237,204,0.258,"homoharringtonine, bruceantin, cycloheximide, clofoctol, anguidine, harringtonine, azomycin..2.nitroimidazole., methacycline",1.6252516539899,0.58838029403677,FALSE +"HCC827","Pearson.est","protein tyrosine kinase inhibitor",-0.42589,-1.11,0.309,1335,0.609,"rheochrysidin, NVP.TAE226, BMS.599626",0.510041520575165,0.215382707367125,FALSE +"HCC827","Pearson.est","RAF inhibitor",0.30153,0.782,0.718,1015,0.905,"SB.590885, sorafenib, regorafenib, CEP.32496, LGX818, AZ.628, dabrafenib, GDC.0879, RAF265, TAK.632, PLX.4720, vemurafenib",0.1438755557577,0.0433514207947967,FALSE +"HCC827","Pearson.est","RET tyrosine kinase inhibitor",0.40245,1.08,0.352,398,0.831,"apatinib, cabozantinib, sunitinib, sorafenib, regorafenib",0.453457336521869,0.080398976215889,FALSE +"HCC827","Pearson.est","retinoid receptor agonist",0.54743,1.43,0.129,371,0.443,"fenretinide, adarotene, LE.135, adapalene, bexarotene",0.889410289700751,0.35359627377693,FALSE +"HCC827","Pearson.est","ribonucleotide reductase inhibitor",0.17392,0.453,0.996,107,0.99,"LY2334737",0.00174066157630127,0.00436480540245009,FALSE +"HCC827","Pearson.est","serotonin receptor agonist",-0.69495,-1.76,0.0202,1447,0.303,"aripiprazole",1.69464863055338,0.518557371497695,FALSE +"HCC827","Pearson.est","serotonin receptor antagonist",-0.473,-1.2,0.261,1413,0.576,"RS.16566, aripiprazole",0.583359492661719,0.239577516576788,FALSE +"HCC827","Pearson.est","sodium channel blocker",0.40495,1.07,0.36,119,0.809,"benzethonium, benzocaine",0.443697499232713,0.0920514783877277,FALSE +"HCC827","Pearson.est","src inhibitor",-0.57138,-1.49,0.0885,1324,0.474,"PP.1, bosutinib, dasatinib",1.05305672930217,0.324221658325915,FALSE +"HCC827","Pearson.est","sterol demethylase inhibitor",0.64518,1.72,0.0384,110,0.322,"chlormidazole, posaconazole, lanoconazole",1.41566877563247,0.492144128304169,FALSE +"HCC827","Pearson.est","TGF beta receptor inhibitor",-0.32684,-0.859,0.621,1124,0.831,"D.4476, repsox, SB.431542",0.20690839982342,0.080398976215889,FALSE +"HCC827","Pearson.est","thymidylate synthase inhibitor",-0.4126,-1.06,0.354,1377,0.667,"capecitabine",0.450996737974212,0.175874166083451,FALSE +"HCC827","Pearson.est","topoisomerase inhibitor",0.32081,0.832,0.657,240,0.873,"doxorubicin, epirubicin, mitoxantrone, etoposide.phosphate, idarubicin, valrubicin, amonafide, nemorubicin, daunorubicin",0.182434630440219,0.0589857562944303,FALSE +"HCC827","Pearson.est","tubulin polymerization inhibitor",0.4528,1.15,0.287,457,0.818,"mebendazole, fenbendazole, vincristine, dolastatin.10, taltobulin, vindesine, parbendazole, indibulin, nocodazole, BNC105, combretastatin.A.4, CYT.997, podophyllotoxin, verubulin, vinblastine, vinorelbine",0.542118103266008,0.087246696328677,FALSE +"HCC827","Pearson.est","tyrosine kinase inhibitor",-0.3844,-1,0.441,1335,0.718,"rheochrysidin, NVP.TAE226, aminopurvalanol.a, BMS.599626, vandetanib, dasatinib",0.355561410532161,0.1438755557577,FALSE +"HCC827","Pearson.est","VEGFR inhibitor",0.37845,0.974,0.46,295,0.89,"dovitinib, PD.173074, lenvatinib, linifanib, tivozanib, pazopanib, golvatinib, motesanib, axitinib, MGCD.265, nintedanib, TG.100572, cabozantinib, sunitinib",0.337242168318426,0.0506099933550872,FALSE +"HCC827","Pearson.est","vitamin D receptor agonist",-0.54553,-1.41,0.151,956,0.575,"alfacalcidol, maxacalcitol, doxercalciferol, ercalcitriol, tacalcitol",0.821023052706831,0.24033215531037,FALSE +"CALU3","Pearson.est","EGFR inhibitor",0.25983,0.677,0.855,373,0.937,"PD.168393, poziotinib, WZ.3146, AST.1306, CP.724714, CGP.52411, tyrphostin.AG.1478, CNX.2006, canertinib, pelitinib, afatinib, brigatinib, WZ.4002, erlotinib",0.0680338852718274,0.0282604091122217,FALSE +"CALU3","Pearson.est","Abl kinase inhibitor",-0.55187,-1.43,0.114,1207,0.355,"imatinib, tozasertib, KW.2449, ponatinib, bafetinib",0.943095148663527,0.449771646944906,FALSE +"CALU3","Pearson.est","acetylcholine receptor agonist",0.42007,1.07,0.374,387,0.79,"xanomeline, oxiracetam, tremorine",0.42712839779952,0.102372908709559,FALSE +"CALU3","Pearson.est","acetylcholine receptor antagonist",0.34091,0.871,0.611,443,0.877,"hyoscyamine, diphemanil, darifenacin",0.213958789757446,0.0570004066339595,FALSE +"CALU3","Pearson.est","adenosine receptor antagonist",-0.36764,-0.956,0.503,1237,0.636,"istradefylline, CGS.15943",0.298432014944073,0.196542884351586,FALSE +"CALU3","Pearson.est","adrenergic receptor agonist",0.28011,0.713,0.808,272,0.941,"lidamidine, xylazine, oxymetazoline, methyldopa, epinephrine",0.0925886392254138,0.0264103765727431,FALSE +"CALU3","Pearson.est","adrenergic receptor antagonist",0.3853,0.978,0.474,156,0.871,"RS.17053, prazosin, imiloxan",0.324221658325915,0.0599818449923368,FALSE +"CALU3","Pearson.est","AKT inhibitor",-0.46821,-1.23,0.22,1131,0.452,"uprosertib, A.674563, ONC201, triciribine, MK.2206",0.657577319177794,0.344861565188618,FALSE +"CALU3","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.33123,-0.859,0.604,1330,0.727,"crizotinib, DMH1, CEP.37440",0.218963061378868,0.138465589140962,FALSE +"CALU3","Pearson.est","androgen receptor antagonist",-0.35028,-0.908,0.53,1104,0.692,"RU.58841, bicalutamide, cyproterone.acetate",0.275724130399211,0.159893905543242,FALSE +"CALU3","Pearson.est","antioxidant",-0.56815,-1.53,0.0814,1262,0.334,"chlorogenic.acid, trolox, taurine",1.0893755951108,0.476253533188435,FALSE +"CALU3","Pearson.est","AP inhibitor",0.75034,1.89,0.00351,187,0.157,"tanshinone.i, birinapant, GDC.0152",2.45469288353418,0.804100347590766,TRUE +"CALU3","Pearson.est","ATPase inhibitor",0.4484,1.12,0.314,251,0.93,"ouabain, rabeprazole, NMS.873, digitoxin, k.strophanthidin",0.503070351926785,0.0315170514460649,FALSE +"CALU3","Pearson.est","Aurora kinase inhibitor",0.34857,0.888,0.578,356,0.908,"PHA.680632, danusertib, TAK.901, CYC116, barasertib.HQPA, GSK1070916, MLN.8054, CCT129202, ZM.447439",0.238072161579471,0.0419141514789149,FALSE +"CALU3","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.47106,-1.24,0.203,1162,0.46,"dirithromycin, azithromycin, valnemulin",0.692503962086787,0.337242168318426,FALSE +"CALU3","Pearson.est","bacterial DNA gyrase inhibitor",0.54973,1.38,0.141,263,0.632,"lomefloxacin, norfloxacin, trovafloxacin, finafloxacin",0.85078088734462,0.199282921717615,FALSE +"CALU3","Pearson.est","BCL inhibitor",-0.60792,-1.59,0.0583,1294,0.32,"venetoclax, TW.37, gossypol",1.23433144524099,0.494850021680094,FALSE +"CALU3","Pearson.est","Bcr.Abl kinase inhibitor",-0.60301,-1.59,0.0603,1207,0.32,"imatinib, tozasertib, ponatinib, bafetinib",1.21968268785985,0.494850021680094,FALSE +"CALU3","Pearson.est","benzodiazepine receptor agonist",0.32703,0.811,0.681,308,0.867,"gamma.aminobutyric.acid, CL.218872, bentazepam, ZK.93423",0.166852888087215,0.0619809025237897,FALSE +"CALU3","Pearson.est","bromodomain inhibitor",-0.65,-1.77,0.0259,954,0.333,"I.BET151, PFI.1, OTX015, JQ1...., bromosporine",1.58670023591875,0.47755576649368,FALSE +"CALU3","Pearson.est","calcium channel blocker",-0.42748,-1.14,0.266,1247,0.518,"cinnarazine, SR.33805, carboxyamidotriazole, penfluridol",0.575118363368933,0.285670240254767,FALSE +"CALU3","Pearson.est","CC chemokine receptor antagonist",-0.40932,-1.07,0.373,1311,0.581,"navarixin, RS.504393",0.428291168191312,0.235823867609669,FALSE +"CALU3","Pearson.est","CDK inhibitor",-0.50937,-1.34,0.162,1157,0.376,"P276.00, indirubin, dinaciclib, PHA.848125, TG.02, NU6027, alvocidib, AZD5438, palbociclib, abemaciclib, kenpaullone",0.790484985457369,0.424812155072339,FALSE +"CALU3","Pearson.est","CHK inhibitor",0.45983,1.17,0.27,226,0.939,"PF.477736, AZD7762",0.568636235841013,0.0273344077338891,FALSE +"CALU3","Pearson.est","cyclooxygenase inhibitor",0.25438,0.649,0.882,123,0.944,"AM.404, naproxen, amfenac, metoxibutropate",0.0545314148681803,0.025028005701931,FALSE +"CALU3","Pearson.est","cytochrome P450 inhibitor",0.57243,1.45,0.115,231,0.863,"PF.4981517, eplerenone, morin",0.939302159646388,0.0639892042847904,FALSE +"CALU3","Pearson.est","DNA alkylating agent",-0.40343,-1.06,0.366,1134,0.575,"ifosfamide, cisplatin, melphalan, mitomycin.c, estramustine, carmustine",0.436518914605589,0.24033215531037,FALSE +"CALU3","Pearson.est","DNA inhibitor",0.25197,0.639,0.891,445,0.907,"sangivamycin, tirapazamine, busulfan, nimorazole, bendamustine, carboplatin, nithiamide, mechlorethamine, valrubicin",0.0501222959631252,0.0423927129399047,FALSE +"CALU3","Pearson.est","DNA methyltransferase inhibitor",-0.32767,-0.848,0.61,1008,0.723,"azacitidine, RG108, decitabine",0.214670164989233,0.140861702705469,FALSE +"CALU3","Pearson.est","DNA polymerase inhibitor",0.3851,0.971,0.475,174,0.848,"famciclovir, cephalomannine, cidofovir",0.323306390375133,0.0716041477432862,FALSE +"CALU3","Pearson.est","DNA synthesis inhibitor",-0.29948,-0.786,0.674,1132,0.777,"enocitabine, cisplatin, mitomycin.c, anisomycin, artesunate",0.17134010346468,0.109578981199086,FALSE +"CALU3","Pearson.est","dopamine receptor antagonist",0.41912,1.08,0.344,306,0.811,"remoxipride, ziprasidone, clebopride, isofloxythepin, thioproperazine, UH.232...., domperidone",0.46344155742847,0.090979145788844,FALSE +"CALU3","Pearson.est","estrogen receptor agonist",0.4296,1.11,0.32,323,0.893,"erteberel, levonorgestrel, estradiol.cypionate, equol, ethinyl.estradiol",0.494850021680094,0.0491485411114536,FALSE +"CALU3","Pearson.est","estrogen receptor antagonist",0.46027,1.18,0.275,173,0.994,"tamoxifen, raloxifene",0.560667306169737,0.00261361560268669,FALSE +"CALU3","Pearson.est","FGFR inhibitor",-0.55715,-1.47,0.107,1024,0.329,"nintedanib, MK.2461, lucitanib, erdafitinib, regorafenib",0.97061622231479,0.482804102050026,FALSE +"CALU3","Pearson.est","FLT3 inhibitor",-0.56232,-1.51,0.0974,1096,0.333,"ENMD.2076, sunitinib, TG.02, tozasertib, KW.2449, quizartinib, pacritinib, ponatinib, sorafenib",1.01144104312138,0.47755576649368,FALSE +"CALU3","Pearson.est","glucocorticoid receptor agonist",0.74322,1.9,0.00684,352,0.288,"hydrocortisone, halcinonide, dexamethasone.acetate, fluticasone.propionate, fluorometholone, flumethasone.pivalate, prednisolone, betamethasone, fluocinolone.acetonide, triamcinolone.acetonide, ciclesonide, triamcinolone, prednisolone.acetate, desonide, clobetasol.propionate, fludroxycortide, deflazacort, methylprednisolone, rimexolone, halobetasol.propionate, piretanide, difluprednate",2.16494389827988,0.540607512240769,FALSE +"CALU3","Pearson.est","glutamate receptor antagonist",0.55284,1.44,0.107,284,0.752,"CPP, kynurenic.acid, IEM1754, CGP.37849, latrepirdine, JNJ.16259685, LY456236",0.97061622231479,0.123782159408358,FALSE +"CALU3","Pearson.est","glycogen synthase kinase inhibitor",-0.3985,-1.03,0.404,1066,0.58,"AZD2858, LY2090314, indirubin, GSK.3.inhibitor.IX, kenpaullone",0.393618634889395,0.236572006437063,FALSE +"CALU3","Pearson.est","growth factor receptor inhibitor",0.45468,1.14,0.303,169,0.946,"danusertib, GSK1904529A",0.518557371497695,0.0241088635982073,FALSE +"CALU3","Pearson.est","HCV inhibitor",-0.54478,-1.42,0.124,1193,0.323,"daclatasvir, Ro.9187",0.906578314837765,0.490797477668897,FALSE +"CALU3","Pearson.est","HDAC inhibitor",-0.60471,-1.62,0.0432,1182,0.373,"mocetinostat, scriptaid, vorinostat, chidamide, PCI.24781, trichostatin.a, givinostat, panobinostat, belinostat, dacinostat, entinostat, R306465, AR.42, M.344, resminostat, RG2833",1.36451625318509,0.428291168191312,FALSE +"CALU3","Pearson.est","histamine receptor antagonist",0.30225,0.782,0.725,428,0.889,"zolantidine, ebastine, ICI.162846, ranitidine, levocetirizine, epinastine, chloropyramine, pheniramine, astemizole",0.139661993429006,0.0510982390297863,FALSE +"CALU3","Pearson.est","HMGCR inhibitor",0.55647,1.39,0.124,84,0.684,"fluvastatin, mevastatin",0.906578314837765,0.164943898279884,FALSE +"CALU3","Pearson.est","HSP inhibitor",0.34382,0.868,0.617,219,0.824,"KW.2478, PU.H71, SNX.2112",0.209714835966758,0.0840727883028842,FALSE +"CALU3","Pearson.est","JAK inhibitor",-0.25379,-0.678,0.836,1216,0.842,"TG.02, tozasertib, TG.101209, pacritinib",0.0777937225609836,0.0746879085003505,FALSE +"CALU3","Pearson.est","KIT inhibitor",-0.50222,-1.3,0.183,1385,0.402,"KI.8751, pazopanib, telatinib, sorafenib, regorafenib",0.737548910269571,0.39577394691553,FALSE +"CALU3","Pearson.est","MDM inhibitor",0.30791,0.777,0.75,1004,0.871,"CGM097, AMG.232, idasanutlin, nutlin.3, serdemetan, RITA",0.1249387366083,0.0599818449923368,FALSE +"CALU3","Pearson.est","MEK inhibitor",0.2591,0.643,0.875,230,0.926,"PD.198306, Ro.4987655, MEK1.2.inhibitor, PD.318088",0.0579919469776868,0.0333890133180656,FALSE +"CALU3","Pearson.est","MET inhibitor",-0.69529,-1.81,0.0194,1174,0.392,"AMG458, NVP.BVU972, LY2801653",1.71219827006977,0.406713932979543,FALSE +"CALU3","Pearson.est","microtubule inhibitor",0.41321,1.05,0.381,642,0.793,"cabazitaxel, vinblastine, colchicine, triclabendazole, podophyllotoxin, cytochalasin.b, secnidazole, vinflunine",0.419075024324381,0.100726812682396,FALSE +"CALU3","Pearson.est","mTOR inhibitor",-0.53121,-1.42,0.114,1058,0.323,"XL388, LY3023414, torin.1, PP242, torin.2, AZD2014, GSK2126458, sirolimus, everolimus, SB.2343, WYE.354, WYE.125132, temsirolimus, GDC.0980, NVP.BEZ235, MLN0128",0.943095148663527,0.490797477668897,FALSE +"CALU3","Pearson.est","NFkB pathway inhibitor",-0.32962,-0.863,0.587,1412,0.742,"betulinic.acid, bortezomib",0.231361898752386,0.129596094720973,FALSE +"CALU3","Pearson.est","opioid receptor agonist",0.38553,1.02,0.425,91,0.819,"spiradoline",0.371611069949688,0.0867160982395816,FALSE +"CALU3","Pearson.est","p38 MAPK inhibitor",0.26787,0.693,0.833,1062,0.942,"CMPD.1, SB.239063, TAK.715, skepinone.l, VX.702, SB.242235, talmapimod",0.0793549985932124,0.0259490972071227,FALSE +"CALU3","Pearson.est","PARP inhibitor",-0.38043,-0.982,0.465,1204,0.635,"endo.IWR.1, E7449",0.332547047110046,0.197226274708024,FALSE +"CALU3","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.58673,-1.57,0.0539,1130,0.313,"sunitinib, motesanib, CP.673451, imatinib, crenolanib, trapidil, KI.8751, pazopanib, ponatinib, telatinib, sorafenib, regorafenib",1.26841123481326,0.504455662453552,FALSE +"CALU3","Pearson.est","phosphatase inhibitor",-0.5206,-1.37,0.128,1209,0.359,"BVT.948, bis.maltolato.oxovanadium.IV., alexidine, GSK2830371",0.892790030352132,0.444905551421681,FALSE +"CALU3","Pearson.est","phosphodiesterase inhibitor",0.32422,0.817,0.66,152,0.885,"cilostamide, trequinsin, papaverine",0.180456064458131,0.0530567293021746,FALSE +"CALU3","Pearson.est","PI3K inhibitor",-0.28277,-0.734,0.769,1065,0.793,"TG.100713, LY3023414, buparlisib, GSK2126458, ZSTK.474, BGT226, SB.2343, TG100.115, GDC.0980, PI3K.IN.2, NVP.BEZ235",0.114073660198569,0.100726812682396,FALSE +"CALU3","Pearson.est","PLK inhibitor",0.54712,1.4,0.124,60,0.754,"HMN.214, NMS.1286937",0.906578314837765,0.122628654130226,FALSE +"CALU3","Pearson.est","potassium channel blocker",0.42019,1.08,0.364,32,0.811,"meglitinide",0.438898616350944,0.090979145788844,FALSE +"CALU3","Pearson.est","PPAR receptor agonist",-0.30326,-0.782,0.684,437,0.764,"ciprofibrate, GW.501516, S26948, fenofibrate, clofibrate, pterostilbene, oleoylethanolamide",0.164943898279884,0.11690664142431,FALSE +"CALU3","Pearson.est","progesterone receptor agonist",0.35669,0.875,0.597,456,0.901,"levonorgestrel, tanaproget, danazol, norgestrel, dienogest",0.224025668870631,0.045275209020937,FALSE +"CALU3","Pearson.est","proteasome inhibitor",-0.40953,-1.07,0.351,1422,0.581,"bortezomib",0.454692883534176,0.235823867609669,FALSE +"CALU3","Pearson.est","protein synthesis inhibitor",0.36677,0.937,0.522,167,0.88,"puromycin, clofoctol, chloramphenicol.palmitate, bruceantin, cycloheximide",0.282329496997738,0.0555173278498314,FALSE +"CALU3","Pearson.est","protein tyrosine kinase inhibitor",0.34834,0.894,0.565,190,0.934,"AV.412, PP.121, CP.724714",0.247951552180562,0.0296531237699066,FALSE +"CALU3","Pearson.est","RAF inhibitor",-0.60907,-1.64,0.0586,1267,0.407,"TAK.632, dabrafenib, sorafenib, regorafenib, SB.590885",1.23210238398191,0.39040559077478,FALSE +"CALU3","Pearson.est","RET tyrosine kinase inhibitor",-0.72827,-1.89,0.00879,1390,0.451,"vandetanib, sorafenib, regorafenib",2.05601112492623,0.345823458122039,FALSE +"CALU3","Pearson.est","retinoid receptor agonist",-0.56984,-1.49,0.0952,1113,0.33,"CD.437, tamibarotene, AM.580, fenretinide",1.02136305161553,0.481486060122112,FALSE +"CALU3","Pearson.est","ribonucleotide reductase inhibitor",-0.28844,-0.748,0.759,1149,0.794,"hydroxyurea, clofarabine, fludarabine",0.11975822410452,0.100179497572904,FALSE +"CALU3","Pearson.est","serotonin receptor agonist",0.49654,1.24,0.228,9,0.911,"aripiprazole",0.642065152999546,0.0404816230270017,FALSE +"CALU3","Pearson.est","serotonin receptor antagonist",0.42996,1.08,0.364,54,0.811,"aripiprazole, ziprasidone",0.438898616350944,0.090979145788844,FALSE +"CALU3","Pearson.est","sodium channel blocker",-0.35732,-0.975,0.451,1238,0.625,"lappaconite, quinidine, triamterene, butamben, ajmaline",0.345823458122039,0.204119982655925,FALSE +"CALU3","Pearson.est","src inhibitor",0.24809,0.627,0.899,1091,0.896,"ZM.306416, KX2.391, saracatinib, TG.100572, masitinib, PP.2, bosutinib, dasatinib, PP.1",0.0462403082667712,0.0476919903378748,FALSE +"CALU3","Pearson.est","sterol demethylase inhibitor",0.34577,0.87,0.576,354,0.849,"lanoconazole, posaconazole",0.239577516576788,0.0710923097560473,FALSE +"CALU3","Pearson.est","TGF beta receptor inhibitor",0.66184,1.66,0.029,351,0.506,"SB.525334, D.4476, repsox",1.53760200210104,0.295849483160201,FALSE +"CALU3","Pearson.est","thymidylate synthase inhibitor",-0.44963,-1.21,0.221,1038,0.457,"trifluridine, carmofur, raltitrexed, doxifluridine",0.655607726314889,0.34008379993015,FALSE +"CALU3","Pearson.est","topoisomerase inhibitor",-0.31403,-0.828,0.628,1312,0.734,"beta.lapachone, topotecan, idarubicin, rubitecan, irinotecan",0.202040356262804,0.134303940083929,FALSE +"CALU3","Pearson.est","tubulin polymerization inhibitor",0.59877,1.53,0.0753,500,0.752,"vincristine, ABT.751, mebendazole, CYT.997, epothilone.b, dolastatin.10, verubulin, indibulin, vinorelbine, paclitaxel, plinabulin, vinblastine, KX2.391, combretastatin.A.4, parbendazole, flubendazole, oxibendazole, BNC105, epothilone.d, podophyllotoxin, vindesine",1.1232050237993,0.123782159408358,FALSE +"CALU3","Pearson.est","tyrosine kinase inhibitor",-0.39852,-1.05,0.384,1375,0.57,"tyrphostin.A9, vandetanib, sorafenib, regorafenib, bafetinib",0.415668775632469,0.244125144327509,FALSE +"CALU3","Pearson.est","VEGFR inhibitor",-0.43778,-1.15,0.302,1016,0.525,"RAF265, MGCD.265, nintedanib, AEE788, ENMD.2076, MK.2461, sunitinib, lucitanib, motesanib, golvatinib, tivozanib, KI.8751, vandetanib, pazopanib, telatinib, sorafenib, regorafenib, foretinib",0.519993057042849,0.279840696594043,FALSE +"CALU3","Pearson.est","vitamin D receptor agonist",-0.65461,-1.72,0.02,1082,0.33,"paricalcitol, maxacalcitol, doxercalciferol, calcitriol, tacalcitol",1.69897000433602,0.481486060122112,FALSE +"H2009","Pearson.est","EGFR inhibitor",-0.53727,-1.27,0.199,1200,0.597,"gefitinib, OSI.420, lapatinib, vandetanib, AZD8931, BMS.599626, PD.153035, GW.583340, XL.647, afatinib, ARRY.334543, TAK.285, osimertinib, tucatinib, CUDC.101, AST.1306, dacomitinib, neratinib, BIBU.1361",0.701146923590293,0.224025668870631,FALSE +"H2009","Pearson.est","Abl kinase inhibitor",-0.23781,-0.561,0.948,1009,0.969,"bosutinib, bafetinib, tozasertib, KW.2449",0.0231916626619338,0.0136762229492347,FALSE +"H2009","Pearson.est","acetylcholine receptor agonist",-0.50287,-1.18,0.255,1252,0.625,"nicotine, pilocarpine",0.593459819566045,0.204119982655925,FALSE +"H2009","Pearson.est","acetylcholine receptor antagonist",-0.2436,-0.578,0.943,905,0.975,"diphemanil, dicycloverine",0.0254883072626717,0.0109953843014632,FALSE +"H2009","Pearson.est","adenosine receptor antagonist",-0.49431,-1.18,0.264,1408,0.625,"CGS.15943",0.578396073130169,0.204119982655925,FALSE +"H2009","Pearson.est","adrenergic receptor agonist",0.29937,0.878,0.581,1019,0.967,"lidamidine, oxymetazoline, epinephrine, xylazine, methyldopa, terbutaline, A61603, metaraminol, ritodrine, midodrine, isoetharine, isoxsuprine, buphenine, clenbuterol, norepinephrine",0.235823867609669,0.0145735259169983,FALSE +"H2009","Pearson.est","adrenergic receptor antagonist",0.20147,0.582,0.938,124,0.946,"prazosin, imiloxan, practolol, RS.17053",0.0277971616209356,0.0241088635982073,FALSE +"H2009","Pearson.est","AKT inhibitor",-0.59603,-1.38,0.097,985,0.503,"AZD5363, CCT128930, palomid.529, MK.2206, GDC.0068, A.674563, triciribine, uprosertib",1.01322826573376,0.298432014944073,FALSE +"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.49555,-1.16,0.273,1227,0.628,"AZD3463, CEP.37440, DMH1",0.563837352959244,0.202040356262804,FALSE +"H2009","Pearson.est","androgen receptor antagonist",0.42094,1.24,0.194,841,0.592,"flutamide, bicalutamide, nilutamide, cyproterone.acetate, enzalutamide, RU.58841",0.712198270069774,0.22767829327708,FALSE +"H2009","Pearson.est","antioxidant",0.26075,0.75,0.754,1072,0.87,"rutin, mesna, benfotiamine, chlorogenic.acid, trolox, taurine",0.122628654130226,0.0604807473813815,FALSE +"H2009","Pearson.est","AP inhibitor",0.40354,1.19,0.249,75,0.599,"birinapant, GDC.0152",0.603800652904264,0.222573177610689,FALSE +"H2009","Pearson.est","ATPase inhibitor",-0.24781,-0.587,0.943,1042,0.985,"oligomycin.a, NMS.873, evodiamine, digoxin",0.0254883072626717,0.00656376950238827,FALSE +"H2009","Pearson.est","Aurora kinase inhibitor",-0.57916,-1.37,0.101,1235,0.46,"AT.9283, PF.03814735, tozasertib, barasertib.HQPA, AMG900, MK.8745, KW.2449, SNS.314, ZM.447439, CCT137690, ENMD.2076, hesperadin",0.995678626217357,0.337242168318426,FALSE +"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.62044,-1.47,0.0676,1029,0.561,"azalomycin.b, valnemulin, tedizolid, radezolid, dirithromycin, azithromycin",1.17005330405836,0.251037138743839,FALSE +"H2009","Pearson.est","bacterial DNA gyrase inhibitor",-0.44206,-1.04,0.416,1387,0.739,"nadifloxacin",0.380906669373257,0.131355561605174,FALSE +"H2009","Pearson.est","BCL inhibitor",-0.65898,-1.52,0.0475,1430,0.483,"TW.37, gossypol",1.32330639037513,0.316052869248488,FALSE +"H2009","Pearson.est","Bcr.Abl kinase inhibitor",0.29753,0.879,0.632,156,1,"dasatinib, GZD824, metatinib",0.199282921717615,0,FALSE +"H2009","Pearson.est","benzodiazepine receptor agonist",-0.29387,-0.71,0.819,1311,0.975,"piperazine, ivermectin",0.0867160982395816,0.0109953843014632,FALSE +"H2009","Pearson.est","bromodomain inhibitor",-0.87725,-2.07,0,1265,0.00753,"I.BET.762, PFI.1, I.BET151, bromosporine, JQ1...., OTX015",Inf,2.1232050237993,TRUE +"H2009","Pearson.est","calcium channel blocker",-0.52847,-1.23,0.222,1131,0.593,"tetrandrine, SKF.96365, penfluridol, mibefradil, carboxyamidotriazole",0.653647025549361,0.226945306635737,FALSE +"H2009","Pearson.est","CC chemokine receptor antagonist",-0.46862,-1.1,0.341,1040,0.707,"ZK811752, PF.04136309, navarixin, SB.225002",0.467245621007502,0.150580586203101,FALSE +"H2009","Pearson.est","CDK inhibitor",-0.59201,-1.41,0.0805,937,0.508,"JNJ.7706621, indirubin, PHA.793887, AZD5438, aminopurvalanol.a, ribociclib, arcyriaflavin.a, R547, BMS.265246, P276.00, dinaciclib, palbociclib, alvocidib, abemaciclib, kenpaullone, BMS.387032, AT.7519, indisulam, TG.02",1.09420411963213,0.294136287716081,FALSE +"H2009","Pearson.est","CHK inhibitor",-0.26798,-0.633,0.907,1079,0.984,"LY2603618, SB.218078",0.0423927129399047,0.00700490156865849,FALSE +"H2009","Pearson.est","cyclooxygenase inhibitor",-0.26523,-0.636,0.908,856,1,"FR.122047, naproxen, tepoxalin, meloxicam, aspirin, curcumin, ketoprofen, ramifenazone, tryptanthrin",0.0419141514789149,0,FALSE +"H2009","Pearson.est","cytochrome P450 inhibitor",0.52486,1.46,0.103,174,0.335,"metyrapone, morin, eplerenone",0.987162775294828,0.474955192963155,FALSE +"H2009","Pearson.est","DNA alkylating agent",-0.53191,-1.25,0.175,1038,0.622,"streptozotocin, cyclophosphamide, carmustine, TH.302, estramustine, satraplatin, melphalan, mitomycin.c",0.756961951313706,0.206209615309181,FALSE +"H2009","Pearson.est","DNA inhibitor",-0.35097,-0.823,0.718,917,0.941,"metronidazole, mechlorethamine, oxaliplatin, bendamustine, teroxirone, carmustine, pibenzimol, primaquine, melphalan",0.1438755557577,0.0264103765727431,FALSE +"H2009","Pearson.est","DNA methyltransferase inhibitor",-0.74668,-1.76,0.00591,1117,0.18,"disulfiram, fdcyd, decitabine, azacitidine",2.22841251911874,0.744727494896694,TRUE +"H2009","Pearson.est","DNA polymerase inhibitor",-0.40808,-0.947,0.559,970,0.825,"cephalomannine, trifluridine, foscarnet, idoxuridine, adefovir.dipivoxil",0.252588192113577,0.0835460514500749,FALSE +"H2009","Pearson.est","DNA synthesis inhibitor",-0.45041,-1.05,0.402,1154,0.758,"enocitabine, anisomycin, cyclocytidine, mitomycin.c",0.39577394691553,0.120330794367946,FALSE +"H2009","Pearson.est","dopamine receptor antagonist",-0.3234,-0.767,0.777,832,0.953,"piperacetazine, amisulpride, domperidone, raclopride, mesoridazine, paliperidone, sertindole, lurasidone",0.109578981199086,0.0209070993616736,FALSE +"H2009","Pearson.est","estrogen receptor agonist",0.22397,0.647,0.911,42,0.945,"estradiol.cypionate",0.0404816230270017,0.0245681914907371,FALSE +"H2009","Pearson.est","estrogen receptor antagonist",-0.25916,-0.613,0.92,1328,0.984,"clomifene",0.0362121726544447,0.00700490156865849,FALSE +"H2009","Pearson.est","FGFR inhibitor",-0.34316,-0.806,0.715,1263,0.93,"lucitanib, regorafenib",0.145693958198919,0.0315170514460649,FALSE +"H2009","Pearson.est","FLT3 inhibitor",-0.51241,-1.23,0.219,1257,0.593,"tozasertib, pacritinib, KW.2449, sorafenib, ENMD.2076, TG.02",0.659555885159882,0.226945306635737,FALSE +"H2009","Pearson.est","glucocorticoid receptor agonist",-0.15164,-0.354,1,956,0.999,"difluprednate, triamcinolone.acetonide, prednisolone, beclomethasone.dipropionate, methylprednisolone, prednisolone.hemisuccinate, deflazacort",0,0.000434511774017692,FALSE +"H2009","Pearson.est","glutamate receptor antagonist",0.5905,1.73,0.0359,159,0.147,"latrepirdine, CGP.37849, JNJ.16259685, kynurenic.acid, SIB.1757, CPP",1.44490555142168,0.832682665251824,TRUE +"H2009","Pearson.est","glycogen synthase kinase inhibitor",0.2648,0.807,0.741,140,0.893,"CHIR.98014, tideglusib, TWS.119",0.130181792020672,0.0491485411114536,FALSE +"H2009","Pearson.est","growth factor receptor inhibitor",-0.4331,-1.01,0.468,1209,0.767,"GSK1838705A, AZD3463",0.329754146925876,0.115204636051019,FALSE +"H2009","Pearson.est","HCV inhibitor",-0.57836,-1.37,0.104,834,0.46,"daclatasvir, PSI.7976, embelin, mericitabine, Ro.9187, narlaprevir",0.98296666070122,0.337242168318426,FALSE +"H2009","Pearson.est","HDAC inhibitor",-0.6056,-1.42,0.0862,1143,0.585,"vorinostat, pyroxamide, RG2833, chidamide, trichostatin.a, belinostat, givinostat, dacinostat, PCI.24781, resminostat, entinostat, R306465, AR.42, M.344",1.06449273417529,0.23284413391782,FALSE +"H2009","Pearson.est","histamine receptor antagonist",-0.26866,-0.634,0.903,969,0.999,"pheniramine, chloropyramine, cyproheptadine, BF2.649, tiotidine, astemizole, famotidine, terfenadine",0.0443122496864942,0.000434511774017692,FALSE +"H2009","Pearson.est","HMGCR inhibitor",0.7871,2.42,0,313,0.0103,"fluvastatin, pitavastatin, simvastatin, atorvastatin, mevastatin, lovastatin",Inf,1.98716277529483,TRUE +"H2009","Pearson.est","HSP inhibitor",-0.5516,-1.31,0.127,1051,0.553,"PU.H71, XL888, SNX.5422, BIIB021, ganetespib, NVP.AUY922, tanespimycin",0.896196279044043,0.257274868695302,FALSE +"H2009","Pearson.est","JAK inhibitor",-0.44305,-1.05,0.403,634,0.758,"ruxolitinib, AZ960, filgotinib, WHI.P154, lestaurtinib, PRT062070, TG.101348, CEP.33779, atiprimod, baricitinib, AZD1480, LY2784544, AT.9283, tozasertib, pacritinib, TG.101209, TG.02",0.39469495385889,0.120330794367946,FALSE +"H2009","Pearson.est","KIT inhibitor",-0.39907,-0.939,0.545,1152,0.804,"tandutinib, pazopanib, OSI.930, regorafenib, sorafenib",0.263603497723358,0.0947439512515487,FALSE +"H2009","Pearson.est","MDM inhibitor",0.69271,1.92,0.027,97,0.0928,"idasanutlin, AMG.232, CGM097, nutlin.3",1.56863623584101,1.03245202378114,TRUE +"H2009","Pearson.est","MEK inhibitor",-0.42005,-0.985,0.489,1094,0.784,"arctigenin, cobimetinib, AZD8330, MEK162, PD.184352, AS.703026, nobiletin, trametinib",0.31069114087638,0.105683937315562,FALSE +"H2009","Pearson.est","MET inhibitor",-0.29327,-0.697,0.841,875,0.973,"LY2801653, INC.280, NVP.BVU972",0.0752040042020878,0.0118871597316481,FALSE +"H2009","Pearson.est","microtubule inhibitor",-0.40087,-0.956,0.522,947,0.827,"cabazitaxel, vinflunine, cytochalasin.b, D.64131",0.282329496997738,0.0824944904474534,FALSE +"H2009","Pearson.est","mTOR inhibitor",-0.33066,-0.768,0.776,619,0.97,"PF.05212384, OSI.027, everolimus, LY3023414, SB.2343, PF.04691502, WYE.354, NVP.BEZ235, voxtalisib, PP242, XL388, temsirolimus, AZD2014, AZD8055, palomid.529, MLN0128, WYE.125132, ku.0063794, torin.2, GDC.0980, GSK2126458",0.110138278741812,0.0132282657337552,FALSE +"H2009","Pearson.est","NFkB pathway inhibitor",-0.50313,-1.19,0.241,838,0.649,"parthenolide, Ro.106.9920, parthenolide...., tyloxapol, curcumin, EVP4593, bortezomib, betulinic.acid",0.617982957425132,0.187755303199631,FALSE +"H2009","Pearson.est","opioid receptor agonist",0.29907,0.829,0.648,130,0.915,"spiradoline, BW.180C",0.188424994129407,0.0385789059335517,FALSE +"H2009","Pearson.est","p38 MAPK inhibitor",-0.55195,-1.3,0.175,974,0.547,"VX.702, SB.239063, SB.242235, talmapimod",0.756961951313706,0.262012673666569,FALSE +"H2009","Pearson.est","PARP inhibitor",-0.49801,-1.17,0.274,1023,0.626,"PJ.34, talazoparib, niraparib, olaparib",0.562249437179612,0.20342566678957,FALSE +"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.31273,-0.741,0.812,1093,0.954,"crenolanib, tandutinib, pazopanib, CP.673451, trapidil, regorafenib, sorafenib",0.0904439707588247,0.0204516252959049,FALSE +"H2009","Pearson.est","phosphatase inhibitor",-0.43324,-1.01,0.465,1401,0.767,"mycophenolic.acid, mycophenolate.mofetil",0.332547047110046,0.115204636051019,FALSE +"H2009","Pearson.est","phosphodiesterase inhibitor",0.35656,1.01,0.421,192,0.927,"anagrelide, enoximone, papaverine",0.375717904164332,0.0329202658555029,FALSE +"H2009","Pearson.est","PI3K inhibitor",-0.4212,-0.997,0.469,1123,0.777,"CUDC.907, PI3K.IN.2, buparlisib, TG.100713, CH5132799, taselisib, GDC.0980, GSK2126458, alpelisib",0.328827157284917,0.109578981199086,FALSE +"H2009","Pearson.est","PLK inhibitor",-0.59733,-1.41,0.0843,897,0.508,"GSK461364, NMS.1286937, rigosertib, GW.843682X, BI.2536, volasertib",1.07417242537526,0.294136287716081,FALSE +"H2009","Pearson.est","potassium channel blocker",0.30919,0.882,0.588,138,1,"meglitinide, dofetilide",0.230622673923862,0,FALSE +"H2009","Pearson.est","PPAR receptor agonist",-0.5831,-1.35,0.103,1027,0.482,"clofibrate, ciprofibrate, oleoylethanolamide",0.987162775294828,0.31695296176115,FALSE +"H2009","Pearson.est","progesterone receptor agonist",-0.38965,-0.925,0.577,1327,0.797,"dienogest, melengestrol.acetate",0.238824186844269,0.0985416786038876,FALSE +"H2009","Pearson.est","proteasome inhibitor",-0.50993,-1.21,0.242,1303,0.621,"carfilzomib, bortezomib",0.616184634019569,0.20690839982342,FALSE +"H2009","Pearson.est","protein synthesis inhibitor",-0.31963,-0.755,0.801,878,0.952,"brefeldin.a, puromycin, clindamycin.phosphate, tedizolid.phosphate, harringtonine, thiostrepton, bruceantin, anguidine, homoharringtonine",0.0963674839157623,0.0213630516155257,FALSE +"H2009","Pearson.est","protein tyrosine kinase inhibitor",-0.5363,-1.24,0.191,979,0.621,"mubritinib, AV.412, BMS.599626, NVP.TAE226, tyrphostin.A9",0.718966632752272,0.20690839982342,FALSE +"H2009","Pearson.est","RAF inhibitor",-0.64891,-1.54,0.045,1118,0.503,"RAF265, SB.590885, AZ.628, GDC.0879, TAK.632, regorafenib, sorafenib",1.34678748622466,0.298432014944073,FALSE +"H2009","Pearson.est","RET tyrosine kinase inhibitor",-0.6588,-1.55,0.0396,1239,0.784,"vandetanib, regorafenib, sorafenib",1.40230481407449,0.105683937315562,FALSE +"H2009","Pearson.est","retinoid receptor agonist",-0.66612,-1.54,0.043,1272,0.503,"bexarotene, fenretinide, tamibarotene, adarotene",1.36653154442041,0.298432014944073,FALSE +"H2009","Pearson.est","ribonucleotide reductase inhibitor",-0.45565,-1.06,0.372,1208,0.781,"fludarabine, clofarabine",0.429457060118102,0.1073489661227,FALSE +"H2009","Pearson.est","serotonin receptor agonist",-0.36885,-0.872,0.646,1222,0.876,"zolmitriptan",0.189767482004916,0.0574958938319193,FALSE +"H2009","Pearson.est","serotonin receptor antagonist",-0.4334,-1.04,0.428,1180,0.739,"SB.228357, paliperidone, sertindole, lurasidone",0.368556230986828,0.131355561605174,FALSE +"H2009","Pearson.est","sodium channel blocker",-0.34658,-0.817,0.697,927,0.932,"brivaracetam, quinidine, A.803467, lappaconite, triamterene, ajmaline, benzethonium",0.156767221901991,0.0305840876460186,FALSE +"H2009","Pearson.est","src inhibitor",0.30438,0.854,0.578,1010,0.937,"dasatinib, saracatinib, masitinib, PP.2, ZM.306416, TG.100572, KX2.391, PP.1, bosutinib",0.238072161579471,0.0282604091122217,FALSE +"H2009","Pearson.est","sterol demethylase inhibitor",0.73343,1.99,0.0137,190,0.106,"lanoconazole, posaconazole, terconazole",1.86327943284359,0.97469413473523,TRUE +"H2009","Pearson.est","TGF beta receptor inhibitor",0.26422,0.755,0.796,1067,0.92,"SB.525334, adaprev, SB.431542, repsox, LY2109761, D.4476",0.0990869322623309,0.0362121726544447,FALSE +"H2009","Pearson.est","thymidylate synthase inhibitor",-0.6042,-1.43,0.0932,898,0.621,"ftorafur, trifluridine, doxifluridine, carmofur, raltitrexed",1.03058408764602,0.20690839982342,FALSE +"H2009","Pearson.est","topoisomerase inhibitor",-0.49235,-1.15,0.285,788,0.629,"licochalcone.a, nemorubicin, amonafide, daunorubicin, voreloxin, etoposide, camptothecin, TAS.103, amsacrine, SN.38, etoposide.phosphate, doxorubicin, fleroxacin, idarubicin, beta.lapachone, irinotecan, topotecan, rubitecan, genz.644282, exatecan.mesylate",0.54515513999149,0.201349354554731,FALSE +"H2009","Pearson.est","tubulin polymerization inhibitor",-0.39577,-0.941,0.561,874,0.818,"KX2.391, epothilone.d, vindesine, parbendazole, vinorelbine, paclitaxel, fenbendazole, nocodazole, fosbretabulin, albendazole, taltobulin, docetaxel",0.251037138743839,0.087246696328677,FALSE +"H2009","Pearson.est","tyrosine kinase inhibitor",-0.47683,-1.13,0.313,1238,0.656,"UNC2250, vandetanib, BMS.599626, regorafenib, sorafenib, NVP.TAE226, tyrphostin.A9, tivantinib",0.504455662453552,0.18309616062434,FALSE +"H2009","Pearson.est","VEGFR inhibitor",-0.39517,-0.938,0.543,993,0.788,"KI.8751, MK.2461, AEE788, RAF265, pazopanib, golvatinib, vandetanib, lucitanib, XL.647, OSI.930, foretinib, regorafenib, sorafenib, ENMD.2076",0.265200170411153,0.103473782510445,FALSE +"H2009","Pearson.est","vitamin D receptor agonist",-0.5892,-1.38,0.101,884,0.503,"paricalcitol, doxercalciferol, alfacalcidol, ercalcitriol, maxacalcitol, tacalcitol",0.995678626217357,0.298432014944073,FALSE +"HCC4006","Pearson.est","EGFR inhibitor",-0.74345,-1.74,0.0123,1237,0.121,"AEE788, pelitinib, BMS.599626, rociletinib, PD.168393, BMS.690514, icotinib, WZ.4002, PD.153035, CP.724714, neratinib, WZ8040, GW.583340, CNX.2006, dacomitinib, TAK.285, tucatinib, AZD8931, lapatinib, gefitinib, erlotinib, canertinib, poziotinib, CUDC.101, ARRY.334543, afatinib, AST.1306, XL.647, osimertinib",1.9100948885606,0.91721462968355,TRUE +"HCC4006","Pearson.est","Abl kinase inhibitor",-0.62212,-1.49,0.0621,1146,0.451,"metatinib, imatinib, bosutinib, KW.2449, tozasertib, ZM.306416",1.20690839982342,0.345823458122039,FALSE +"HCC4006","Pearson.est","acetylcholine receptor agonist",-0.56819,-1.36,0.119,1280,0.51,"xanomeline, pilocarpine",0.924453038607469,0.292429823902064,FALSE +"HCC4006","Pearson.est","acetylcholine receptor antagonist",0.55555,1.65,0.0305,341,0.248,"methscopolamine, diphemanil, dicycloverine, hyoscyamine",1.51570016065321,0.605548319173784,TRUE +"HCC4006","Pearson.est","adenosine receptor antagonist",-0.44388,-1.04,0.431,1445,0.646,"CGS.15943",0.365522729839268,0.189767482004916,FALSE +"HCC4006","Pearson.est","adrenergic receptor agonist",0.25188,0.774,0.756,817,0.873,"oxymetazoline, xylazine, epinephrine, isoetharine, terbutaline, norepinephrine, clenbuterol, ritodrine, metaraminol, A61603, lidamidine, buphenine, methyldopa, isoxsuprine",0.121478204498793,0.0589857562944303,FALSE +"HCC4006","Pearson.est","adrenergic receptor antagonist",0.17671,0.52,0.987,37,0.977,"imiloxan, atenolol....",0.00568284733036327,0.0101054362812269,FALSE +"HCC4006","Pearson.est","AKT inhibitor",-0.77152,-1.85,0.00592,1223,0.0796,"GSK2110183, CCT128930, MK.2206, AZD5363, GDC.0068, A.674563, triciribine, uprosertib",2.22767829327708,1.09908693226233,TRUE +"HCC4006","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.52524,-1.25,0.206,1038,0.552,"AP26113, CEP.37440, brigatinib, DMH1, alectinib, AZD3463",0.686132779630847,0.258060922270801,FALSE +"HCC4006","Pearson.est","androgen receptor antagonist",0.8142,2.37,0,250,0.0131,"nilutamide, enzalutamide, flutamide, bicalutamide, cyproterone.acetate",Inf,1.88272870434424,TRUE +"HCC4006","Pearson.est","antioxidant",-0.31729,-0.752,0.804,489,0.887,"trolox, taurine, mesna, chlorogenic.acid, rutin",0.0947439512515487,0.0520763801682736,FALSE +"HCC4006","Pearson.est","AP inhibitor",-0.44261,-1.06,0.402,1135,0.642,"tanshinone.i, embelin",0.39577394691553,0.192464971931147,FALSE +"HCC4006","Pearson.est","ATPase inhibitor",0.27771,0.767,0.702,175,0.846,"k.strophanthidin, digitoxigenin, ouabain, digitoxin",0.153662887870195,0.0726296369609765,FALSE +"HCC4006","Pearson.est","Aurora kinase inhibitor",-0.78223,-1.86,0.00116,1119,0.14,"SNS.314, MK.5108, PF.03814735, CYC116, CCT129202, aurora.a.inhibitor.i, ENMD.2076, alisertib, KW.2449, tozasertib, AMG900, CCT137690, MK.8745, TAK.901, barasertib, PHA.680632, danusertib, AT.9283, barasertib.HQPA, GSK1070916, hesperadin, ZM.447439",2.93554201077308,0.853871964321762,TRUE +"HCC4006","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.44049,-1.05,0.416,862,0.644,"tedizolid, tilmicosin, azalomycin.b, valnemulin, radezolid",0.380906669373257,0.191114132640188,FALSE +"HCC4006","Pearson.est","bacterial DNA gyrase inhibitor",0.69256,2.03,0.0112,327,0.073,"sarafloxacin, sparfloxacin, novobiocin, lomefloxacin, nadifloxacin",1.95078197732982,1.13667713987954,TRUE +"HCC4006","Pearson.est","BCL inhibitor",0.27775,0.817,0.65,220,0.881,"HA14.1, navitoclax, oridonin",0.187086643357144,0.0550240915879521,FALSE +"HCC4006","Pearson.est","Bcr.Abl kinase inhibitor",-0.55632,-1.32,0.142,1001,0.504,"bafetinib, metatinib, imatinib, bosutinib, tozasertib",0.847711655616944,0.297569463554475,FALSE +"HCC4006","Pearson.est","benzodiazepine receptor agonist",0.24298,0.694,0.828,286,0.915,"gamma.aminobutyric.acid, eprinomectin, CL.218872, temazepam, CGS.20625, indiplon, bentazepam",0.0819696632151199,0.0385789059335517,FALSE +"HCC4006","Pearson.est","bromodomain inhibitor",-0.61661,-1.44,0.0612,1139,0.429,"I.BET.762, I.BET151, OTX015, JQ1....",1.21324857785444,0.367542707815276,FALSE +"HCC4006","Pearson.est","calcium channel blocker",-0.53905,-1.25,0.199,896,0.552,"fendiline, cinnarazine, SR.33805, tetrandrine, mibefradil, carboxyamidotriazole, penfluridol",0.701146923590293,0.258060922270801,FALSE +"HCC4006","Pearson.est","CC chemokine receptor antagonist",-0.40456,-0.977,0.494,929,0.735,"SB.225002, navarixin, ZK811752, MK.0812",0.306273051076353,0.133712660915805,FALSE +"HCC4006","Pearson.est","CDK inhibitor",-0.66952,-1.6,0.0232,1224,0.25,"ribociclib, BMS.265246, JNJ.7706621, abemaciclib, palbociclib, P276.00, aminopurvalanol.a, indisulam, R547, BMS.387032, alvocidib, PHA.793887, dinaciclib, AT.7519",1.6345120151091,0.602059991327962,FALSE +"HCC4006","Pearson.est","CHK inhibitor",-0.53574,-1.27,0.204,772,0.561,"LY2606368, SCH.900776, CHIR.124, PF.477736, SB.218078, AZD7762, LY2603618",0.690369832574101,0.251037138743839,FALSE +"HCC4006","Pearson.est","cyclooxygenase inhibitor",0.29372,0.88,0.566,103,0.842,"sulfasalazine, AM.404, tepoxalin, naproxen, piroxicam, phenylbutazone",0.247183568811729,0.0746879085003505,FALSE +"HCC4006","Pearson.est","cytochrome P450 inhibitor",0.5521,1.59,0.0809,282,0.256,"morin, itraconazole, eplerenone, metyrapone, clotrimazole",1.09205147838773,0.59176003468815,FALSE +"HCC4006","Pearson.est","DNA alkylating agent",-0.3959,-0.959,0.517,959,0.734,"cyclophosphamide, estramustine, satraplatin, TH.302, mitomycin.c",0.286509456906058,0.134303940083929,FALSE +"HCC4006","Pearson.est","DNA inhibitor",-0.34161,-0.81,0.742,1149,0.9,"valrubicin, teroxirone, primaquine, oxaliplatin",0.129596094720973,0.0457574905606751,FALSE +"HCC4006","Pearson.est","DNA methyltransferase inhibitor",-0.74579,-1.76,0.00364,1404,0.131,"azacitidine, fdcyd, decitabine",2.43889861635094,0.882728704344236,TRUE +"HCC4006","Pearson.est","DNA polymerase inhibitor",-0.49189,-1.17,0.26,1084,0.526,"trifluridine, adefovir.dipivoxil, cephalomannine, cidofovir, idoxuridine",0.585026652029182,0.279014255846261,FALSE +"HCC4006","Pearson.est","DNA synthesis inhibitor",-0.42974,-1.03,0.431,1008,0.648,"floxuridine, azodicarbonamide, anisomycin, enocitabine, cyclocytidine, mitomycin.c",0.365522729839268,0.188424994129407,FALSE +"HCC4006","Pearson.est","dopamine receptor antagonist",-0.25114,-0.598,0.94,833,0.931,"lurasidone, ziprasidone, piperacetazine, mesoridazine, thioproperazine, sertindole, acetophenazine",0.0268721464003014,0.0310503190186574,FALSE +"HCC4006","Pearson.est","estrogen receptor agonist",0.53264,1.56,0.0933,681,0.219,"estradiol, ethinyl.estradiol, erteberel, estradiol.cypionate, levonorgestrel, PPT, estrone, equol",1.0301183562535,0.659555885159882,FALSE +"HCC4006","Pearson.est","estrogen receptor antagonist",-0.54336,-1.29,0.167,1360,0.544,"clomifene",0.777283528852417,0.26440110030182,FALSE +"HCC4006","Pearson.est","FGFR inhibitor",-0.30098,-0.723,0.832,715,0.888,"lenvatinib, nintedanib, AZD4547, PD.173074, regorafenib, lucitanib",0.0798766737092761,0.051587034221399,FALSE +"HCC4006","Pearson.est","FLT3 inhibitor",-0.4707,-1.11,0.331,1253,0.578,"ENMD.2076, pacritinib, KW.2449, sorafenib, tozasertib",0.480172006224281,0.238072161579471,FALSE +"HCC4006","Pearson.est","glucocorticoid receptor agonist",-0.29674,-0.71,0.839,664,0.869,"triamcinolone, betamethasone, dexamethasone.acetate, desonide, fludroxycortide, ciclesonide, triamcinolone.acetonide, halcinonide, fluorometholone, clobetasol.propionate, prednisolone.hemisuccinate, difluprednate, fluticasone.propionate, halobetasol.propionate, deflazacort, flumethasone, flumethasone.pivalate, methylprednisolone",0.0762380391712997,0.0609802235513335,FALSE +"HCC4006","Pearson.est","glutamate receptor antagonist",0.34946,1.03,0.4,96,0.716,"JNJ.16259685, latrepirdine, kynurenic.acid, diazooxonorleucine",0.397940008672038,0.145086977692144,FALSE +"HCC4006","Pearson.est","glycogen synthase kinase inhibitor",0.3222,0.947,0.547,170,0.79,"tideglusib, CHIR.99021, CHIR.98014",0.262012673666569,0.102372908709559,FALSE +"HCC4006","Pearson.est","growth factor receptor inhibitor",-0.55933,-1.33,0.146,806,0.55,"lestaurtinib, GSK1904529A, GW.441756, PHA.848125, GSK1838705A, danusertib, AZD3463",0.835647144215563,0.259637310505756,FALSE +"HCC4006","Pearson.est","HCV inhibitor",-0.46547,-1.11,0.325,785,0.578,"mericitabine, PSI.7976, embelin, narlaprevir",0.488116639021126,0.238072161579471,FALSE +"HCC4006","Pearson.est","HDAC inhibitor",-0.57726,-1.37,0.124,1151,0.525,"entinostat, R306465, ACY.1215, resminostat, M.344, SB.939, trichostatin.a, dacinostat, scriptaid, vorinostat, chidamide, AR.42, PCI.24781, givinostat",0.906578314837765,0.279840696594043,FALSE +"HCC4006","Pearson.est","histamine receptor antagonist",-0.33424,-0.806,0.728,1068,0.887,"pheniramine, terfenadine, ebastine, tiotidine, levocetirizine",0.137868620686963,0.0520763801682736,FALSE +"HCC4006","Pearson.est","HMGCR inhibitor",0.85407,2.48,0,56,0.00749,"pitavastatin, fluvastatin, mevastatin, atorvastatin",Inf,2.12551818230053,TRUE +"HCC4006","Pearson.est","HSP inhibitor",-0.47821,-1.16,0.267,817,0.528,"SNX.5422, BIIB021, SNX.2112, ganetespib, VER.49009, NVP.AUY922, XL888, PU.H71, alvespimycin, tanespimycin",0.573488738635425,0.277366077466188,FALSE +"HCC4006","Pearson.est","JAK inhibitor",-0.4891,-1.17,0.28,1142,0.526,"ruxolitinib, WHI.P154, AZ960, pacritinib, tozasertib, PRT062070, AT.9283",0.552841968657781,0.279014255846261,FALSE +"HCC4006","Pearson.est","KIT inhibitor",-0.36104,-0.861,0.658,1039,0.855,"KI.8751, vatalanib, regorafenib, imatinib, sorafenib, OSI.930",0.181774106386044,0.0680338852718274,FALSE +"HCC4006","Pearson.est","MDM inhibitor",0.49902,1.51,0.0651,104,0.211,"idasanutlin, AMG.232, nutlin.3",1.18641901143181,0.675717544702307,FALSE +"HCC4006","Pearson.est","MEK inhibitor",-0.37452,-0.899,0.607,736,0.806,"U.0126, refametinib, AS.703026, selumetinib, MEK162, Ro.4987655, arctigenin, PD.0325901, TAK.733, cobimetinib, PD.184352, AZD8330, trametinib, nobiletin",0.216811308924742,0.0936649581949093,FALSE +"HCC4006","Pearson.est","MET inhibitor",0.51321,1.56,0.0506,79,0.219,"PF.04217903, PHA.665752",1.2958494831602,0.659555885159882,FALSE +"HCC4006","Pearson.est","microtubule inhibitor",-0.50496,-1.22,0.212,893,0.568,"colchicine, cytochalasin.b, vinflunine, podophyllotoxin, cabazitaxel, D.64131",0.673664139071249,0.245651664288981,FALSE +"HCC4006","Pearson.est","mTOR inhibitor",-0.49359,-1.18,0.26,879,0.544,"temsirolimus, OSI.027, LY303511, WYE.354, WYE.125132, SB.2343, deforolimus, NVP.BEZ235, XL388, LY3023414, PF.04691502, PKI.179, everolimus, GDC.0980, AZD8055, MLN0128, AZD2014, torin.2, PF.05212384, GSK2126458",0.585026652029182,0.26440110030182,FALSE +"HCC4006","Pearson.est","NFkB pathway inhibitor",-0.309,-0.733,0.816,889,0.892,"curcumin, Ro.106.9920, IKK.2.inhibitor.V, bortezomib, EVP4593, betulinic.acid",0.0883098412461389,0.0496351456238769,FALSE +"HCC4006","Pearson.est","opioid receptor agonist",0.39875,1.16,0.253,873,0.57,"BW.180C, cebranopadol, spiradoline, ADL5859, trimebutine, salvinorin.a",0.596879478824182,0.244125144327509,FALSE +"HCC4006","Pearson.est","p38 MAPK inhibitor",-0.39369,-0.963,0.526,925,0.744,"SB.242235, VX.702, SB.239063, talmapimod",0.279014255846261,0.128427064454121,FALSE +"HCC4006","Pearson.est","PARP inhibitor",-0.32834,-0.789,0.756,721,0.874,"AG.14361, E7449, talazoparib, niraparib",0.121478204498793,0.058488567365597,FALSE +"HCC4006","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.32531,-0.773,0.756,940,0.878,"sunitinib, SU014813, KI.8751, trapidil, crenolanib, vatalanib, regorafenib, imatinib, sorafenib",0.121478204498793,0.0565054840938974,FALSE +"HCC4006","Pearson.est","phosphatase inhibitor",0.30622,0.913,0.548,28,0.814,"bis.maltolato.oxovanadium.IV., BVT.948",0.261219441515631,0.0893755951107988,FALSE +"HCC4006","Pearson.est","phosphodiesterase inhibitor",0.53794,1.54,0.105,124,0.211,"anagrelide, GSK256066, enoximone, avanafil",0.978810700930062,0.675717544702307,FALSE +"HCC4006","Pearson.est","PI3K inhibitor",-0.55516,-1.32,0.147,1019,0.504,"SB.2343, YM.201636, NVP.BEZ235, LY3023414, PF.04691502, PI3K.IN.2, CUDC.907, PKI.179, BGT226, buparlisib, CH5132799, GDC.0980, PF.05212384, TG.100713, PIK.75, GSK2126458, alpelisib, taselisib",0.832682665251824,0.297569463554475,FALSE +"HCC4006","Pearson.est","PLK inhibitor",-0.61724,-1.48,0.0568,1236,0.42,"volasertib, GW.843682X, BI.2536, NMS.1286937",1.24565166428898,0.3767507096021,FALSE +"HCC4006","Pearson.est","potassium channel blocker",0.26768,0.799,0.706,1062,0.871,"dofetilide, meglitinide, mepivacaine, ibutilide, oleoylethanolamide, ML133",0.151195298948196,0.0599818449923368,FALSE +"HCC4006","Pearson.est","PPAR receptor agonist",0.55448,1.66,0.0122,649,0.293,"clofibrate, GW.501516, fenofibrate, pterostilbene, oleoylethanolamide, S26948, ciprofibrate",1.91364016932525,0.533132379645891,FALSE +"HCC4006","Pearson.est","progesterone receptor agonist",0.51179,1.49,0.0694,108,0.203,"norethindrone.acetate, norethindrone, norgestrel",1.15864052954514,0.692503962086787,FALSE +"HCC4006","Pearson.est","proteasome inhibitor",0.24722,0.692,0.804,1092,0.881,"MG.132, oprozomib, ixazomib.citrate, ixazomib, ONX.0914, delanzomib, carfilzomib, bortezomib",0.0947439512515487,0.0550240915879521,FALSE +"HCC4006","Pearson.est","protein synthesis inhibitor",-0.506,-1.22,0.21,1168,0.568,"azomycin..2.nitroimidazole., puromycin, homoharringtonine, anguidine, bruceantin, tedizolid.phosphate, thiostrepton",0.677780705266081,0.245651664288981,FALSE +"HCC4006","Pearson.est","protein tyrosine kinase inhibitor",-0.72377,-1.72,0.0073,1174,0.115,"tyrphostin.A9, mubritinib, AV.412, BMS.599626, CP.724714, NVP.TAE226",2.13667713987954,0.939302159646388,TRUE +"HCC4006","Pearson.est","RAF inhibitor",-0.30709,-0.721,0.855,978,0.873,"RAF265, AZ.628, regorafenib, CEP.32496, TAK.632, sorafenib",0.0680338852718274,0.0589857562944303,FALSE +"HCC4006","Pearson.est","RET tyrosine kinase inhibitor",-0.58893,-1.4,0.0865,940,0.489,"sunitinib, cabozantinib, vandetanib, regorafenib, sorafenib",1.06298389253519,0.31069114087638,FALSE +"HCC4006","Pearson.est","retinoid receptor agonist",-0.33284,-0.789,0.757,891,0.874,"fenretinide, tamibarotene, bexarotene, AM.580, CD.437",0.120904120499927,0.058488567365597,FALSE +"HCC4006","Pearson.est","ribonucleotide reductase inhibitor",0.28164,0.823,0.624,1043,0.915,"pentostatin, hydroxyurea, fludarabine, triapine, cladribine, cytarabine, LY2334737, clofarabine, fludarabine.phosphate, gemcitabine",0.204815410317576,0.0385789059335517,FALSE +"HCC4006","Pearson.est","serotonin receptor agonist",0.33789,0.985,0.438,14,0.761,"NAN.190",0.3585258894959,0.118615343229427,FALSE +"HCC4006","Pearson.est","serotonin receptor antagonist",-0.35534,-0.838,0.697,765,0.875,"SB.228357, lurasidone, ziprasidone, aripiprazole, SB.216641, RS.16566, sertindole",0.156767221901991,0.0579919469776868,FALSE +"HCC4006","Pearson.est","sodium channel blocker",-0.26301,-0.62,0.917,1023,0.932,"lappaconite, ajmaline, benzethonium, brivaracetam",0.0376306643299789,0.0305840876460186,FALSE +"HCC4006","Pearson.est","src inhibitor",-0.47056,-1.12,0.32,1264,0.594,"bosutinib, ZM.306416",0.494850021680094,0.226213555018806,FALSE +"HCC4006","Pearson.est","sterol demethylase inhibitor",0.36755,1.07,0.336,918,0.687,"posaconazole, lanoconazole, chlormidazole, terconazole, ketoconazole, sulconazole",0.473660722610156,0.16304326294045,FALSE +"HCC4006","Pearson.est","TGF beta receptor inhibitor",-0.40083,-0.951,0.565,578,0.731,"LY2109761, D.4476, SB.431542, adaprev, repsox, SB.525334",0.247951552180562,0.13608262304214,FALSE +"HCC4006","Pearson.est","thymidylate synthase inhibitor",-0.60835,-1.45,0.0778,1045,0.451,"doxifluridine, trifluridine, carmofur, raltitrexed",1.10902040301031,0.345823458122039,FALSE +"HCC4006","Pearson.est","topoisomerase inhibitor",-0.46263,-1.08,0.377,795,0.62,"amsacrine, idarubicin, doxorubicin, beta.lapachone, teniposide, irinotecan, epirubicin, voreloxin, daunorubicin, valrubicin, etoposide, licochalcone.a, camptothecin, genz.644282, amonafide, TAS.103, SN.38, exatecan.mesylate",0.423658649794207,0.207608310501746,FALSE +"HCC4006","Pearson.est","tubulin polymerization inhibitor",-0.50092,-1.2,0.243,992,0.543,"vinorelbine, vincristine, ABT.751, dolastatin.10, mebendazole, podophyllotoxin, flubendazole, parbendazole, indibulin, paclitaxel, plinabulin, oxibendazole, epothilone.b, nocodazole, fosbretabulin, docetaxel, albendazole",0.614393726401688,0.265200170411153,FALSE +"HCC4006","Pearson.est","tyrosine kinase inhibitor",-0.51397,-1.21,0.221,912,0.566,"tyrphostin.AG.99, sunitinib, cabozantinib, vandetanib, bafetinib, tivantinib, tyrphostin.A9, regorafenib, mubritinib, AV.412, UNC2250, sorafenib, BMS.599626, aminopurvalanol.a, CP.724714, NVP.TAE226",0.655607726314889,0.247183568811729,FALSE +"HCC4006","Pearson.est","VEGFR inhibitor",-0.49355,-1.2,0.223,940,0.543,"sunitinib, PD.173074, cabozantinib, RAF265, vandetanib, SU014813, KI.8751, vatalanib, foretinib, regorafenib, AEE788, ENMD.2076, sorafenib, OSI.930, golvatinib, BMS.690514, lucitanib, ZM.306416, XL.647",0.651695136951839,0.265200170411153,FALSE +"HCC4006","Pearson.est","vitamin D receptor agonist",-0.49591,-1.18,0.25,848,0.544,"paricalcitol, alfacalcidol, ercalcitriol, maxacalcitol, tacalcitol",0.602059991327962,0.26440110030182,FALSE +"HCC2279","Pearson.est","EGFR inhibitor",0.22816,0.527,0.963,723,1,"CUDC.101, tucatinib, dovitinib, TAK.285, AST.1306, GW.583340, WZ.3146, salvianolic.acid.B, rociletinib, tyrphostin.AG.1478, ARRY.334543, AEE788, BIBX.1382, CP.724714, afatinib, CNX.2006, BIBU.1361, lapatinib, WZ.4002, neratinib, OSI.420, osimertinib",0.0163737128754655,0,FALSE +"HCC2279","Pearson.est","Abl kinase inhibitor",0.3736,0.851,0.677,337,0.83,"tozasertib, imatinib, bafetinib, KW.2449",0.169411331314856,0.0809219076239261,FALSE +"HCC2279","Pearson.est","acetylcholine receptor agonist",0.36498,0.845,0.703,389,0.823,"xanomeline, oxiracetam",0.153044674980176,0.0846001647877302,FALSE +"HCC2279","Pearson.est","acetylcholine receptor antagonist",-0.42322,-1.18,0.217,1080,0.391,"hyoscyamine, methscopolamine, dicycloverine, iododexetimide",0.66354026615147,0.407823242604133,FALSE +"HCC2279","Pearson.est","adenosine receptor antagonist",0.39903,0.916,0.587,873,0.757,"CGS.15943, MRS.1220, SCH.58261, PSB.1115, sulmazole, theophylline, istradefylline",0.231361898752386,0.120904120499927,FALSE +"HCC2279","Pearson.est","adrenergic receptor agonist",-0.56204,-1.63,0.0526,1199,0.213,"methyldopa, ritodrine, isoetharine, isoxsuprine, epinephrine, terbutaline, oxymetazoline, xylazine",1.27901425584626,0.671620396561262,FALSE +"HCC2279","Pearson.est","adrenergic receptor antagonist",0.29627,0.688,0.868,676,0.999,"atipamezole, practolol, atenolol......, dihydroergocristine, oxprenolol, carvedilol, dronedarone, vincamine, idazoxan, propranolol, RS.17053",0.0614802748235081,0.000434511774017692,FALSE +"HCC2279","Pearson.est","AKT inhibitor",0.67717,1.55,0.0301,370,0.222,"uprosertib, GDC.0068, A.674563, GSK2110183, triciribine, MK.2206, ONC201, AZD5363",1.52143350440616,0.653647025549361,TRUE +"HCC2279","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.23651,0.557,0.96,517,1,"AZD3463, DMH1, NVP.TAE684, alectinib, crizotinib",0.0177287669604316,0,FALSE +"HCC2279","Pearson.est","androgen receptor antagonist",-0.78583,-2.3,0,1201,0.0261,"enzalutamide, nilutamide, cyproterone.acetate, flutamide, bicalutamide",Inf,1.58335949266172,TRUE +"HCC2279","Pearson.est","antioxidant",-0.73857,-2.06,0.0162,1147,0.0515,"benfotiamine, taurine, rutin, mesna",1.79048498545737,1.28819277095881,TRUE +"HCC2279","Pearson.est","AP inhibitor",-0.48255,-1.32,0.156,1373,0.307,"birinapant, GDC.0152",0.806875401645538,0.512861624522813,FALSE +"HCC2279","Pearson.est","ATPase inhibitor",0.55578,1.27,0.182,129,0.433,"oligomycin.a, evodiamine, digoxin, NMS.873",0.739928612014925,0.363512103646635,FALSE +"HCC2279","Pearson.est","Aurora kinase inhibitor",0.76469,1.78,0.00249,240,0.126,"CCT137690, barasertib.HQPA, PHA.680632, AT.9283, barasertib, SNS.314, hesperadin, danusertib, AMG900, ZM.447439, alisertib, MK.8745, TAK.901, tozasertib, aurora.a.inhibitor.i, ENMD.2076, GSK1070916, PF.03814735",2.60380065290426,0.899629454882437,TRUE +"HCC2279","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.4393,1.01,0.483,215,0.784,"valnemulin, azalomycin.b",0.316052869248488,0.105683937315562,FALSE +"HCC2279","Pearson.est","bacterial DNA gyrase inhibitor",-0.32014,-0.886,0.556,461,0.649,"nadifloxacin, norfloxacin, novobiocin, lomefloxacin, trovafloxacin, sparfloxacin, finafloxacin, sarafloxacin",0.254925208417942,0.187755303199631,FALSE +"HCC2279","Pearson.est","BCL inhibitor",0.56715,1.3,0.151,236,0.409,"TW.37, gossypol, obatoclax",0.821023052706831,0.388276691992658,FALSE +"HCC2279","Pearson.est","Bcr.Abl kinase inhibitor",-0.38612,-1.12,0.309,1447,0.44,"dasatinib",0.510041520575165,0.356547323513813,FALSE +"HCC2279","Pearson.est","benzodiazepine receptor agonist",-0.31433,-0.863,0.59,1311,0.656,"temazepam, gamma.aminobutyric.acid, eprinomectin, CGS.20625",0.229147988357856,0.18309616062434,FALSE +"HCC2279","Pearson.est","bromodomain inhibitor",0.96117,2.22,0,62,0,"OTX015, JQ1...., I.BET151, I.BET.762, PFI.1, bromosporine",Inf,Inf,TRUE +"HCC2279","Pearson.est","calcium channel blocker",0.7162,1.64,0.0134,178,0.161,"carboxyamidotriazole, mibefradil, SR.33805, tetrandrine, penfluridol",1.87289520163519,0.79317412396815,TRUE +"HCC2279","Pearson.est","CC chemokine receptor antagonist",0.51143,1.17,0.281,230,0.51,"SB.225002, ZK811752",0.55129368009492,0.292429823902064,FALSE +"HCC2279","Pearson.est","CDK inhibitor",0.66741,1.55,0.0319,227,0.222,"indisulam, BMS.387032, TG.02, dinaciclib, R547, P276.00, AT.7519, palbociclib, abemaciclib, JNJ.7706621, PHA.793887, arcyriaflavin.a, ribociclib",1.49620931694282,0.653647025549361,TRUE +"HCC2279","Pearson.est","CHK inhibitor",0.19251,0.442,0.996,239,1,"SB.218078",0.00174066157630127,0,FALSE +"HCC2279","Pearson.est","cyclooxygenase inhibitor",0.18898,0.437,0.992,598,0.993,"curcumin, tepoxalin, piroxicam, FR.122047, ketoprofen, tryptanthrin, ramifenazone",0.00348832784582135,0.00305075150461883,FALSE +"HCC2279","Pearson.est","cytochrome P450 inhibitor",-0.76497,-2.26,0,1280,0.0174,"metyrapone, morin, eplerenone, clotrimazole, itraconazole",Inf,1.7594507517174,TRUE +"HCC2279","Pearson.est","DNA alkylating agent",0.53353,1.23,0.217,293,0.459,"mitomycin.c, TH.302, satraplatin, estramustine, melphalan, cyclophosphamide",0.66354026615147,0.338187314462739,FALSE +"HCC2279","Pearson.est","DNA inhibitor",0.48074,1.11,0.334,278,0.618,"oxaliplatin, chlorambucil, valrubicin, pibenzimol, primaquine, teroxirone, melphalan",0.476253533188435,0.209011524911184,FALSE +"HCC2279","Pearson.est","DNA methyltransferase inhibitor",0.65327,1.49,0.0532,406,0.249,"fdcyd, azacitidine, disulfiram, SGI.1027, decitabine",1.27408836770495,0.603800652904264,FALSE +"HCC2279","Pearson.est","DNA polymerase inhibitor",0.42745,0.971,0.527,269,0.743,"trifluridine, idoxuridine, cephalomannine",0.278189384787453,0.129011186239425,FALSE +"HCC2279","Pearson.est","DNA synthesis inhibitor",0.4049,0.933,0.554,348,0.744,"mitomycin.c, cyclocytidine, anisomycin, enocitabine, floxuridine",0.25649023527157,0.128427064454121,FALSE +"HCC2279","Pearson.est","dopamine receptor antagonist",0.20648,0.475,0.994,65,1,"sertindole",0.00261361560268669,0,FALSE +"HCC2279","Pearson.est","estrogen receptor agonist",-0.60855,-1.76,0.0326,1425,0.156,"estradiol.cypionate",1.48678239993206,0.806875401645538,TRUE +"HCC2279","Pearson.est","estrogen receptor antagonist",0.22205,0.512,0.977,681,1,"clomifene, toremifene, fulvestrant",0.0101054362812269,0,FALSE +"HCC2279","Pearson.est","FGFR inhibitor",0.55021,1.25,0.177,497,0.454,"regorafenib, lucitanib, dovitinib, erdafitinib, lenvatinib, PD.173074",0.752026733638193,0.342944147142896,FALSE +"HCC2279","Pearson.est","FLT3 inhibitor",0.62166,1.46,0.069,412,0.242,"sorafenib, pacritinib, TG.02, tozasertib, quizartinib, TG.101348, ENMD.2076, dovitinib, KW.2449, lestaurtinib, sunitinib",1.16115090926274,0.616184634019569,FALSE +"HCC2279","Pearson.est","glucocorticoid receptor agonist",-0.17147,-0.496,0.995,244,0.987,"deflazacort, rimexolone, methylprednisolone, betamethasone, difluprednate, halobetasol.propionate, prednisolone.hemisuccinate, ciclesonide, flumethasone, prednisolone, fludroxycortide, flumethasone.pivalate, fluticasone.propionate, halcinonide, clobetasol.propionate, fluorometholone, beclomethasone.dipropionate, triamcinolone, desonide, triamcinolone.acetonide, hydrocortisone, prednisolone.acetate, dexamethasone.acetate, piretanide, fluocinolone.acetonide",0.00217691925427455,0.00568284733036327,FALSE +"HCC2279","Pearson.est","glutamate receptor antagonist",-0.55341,-1.6,0.0833,1165,0.205,"CGP.37849, tiletamine, MTPG, kynurenic.acid, diazooxonorleucine, JNJ.16259685, SIB.1757, latrepirdine",1.07935499859321,0.688246138944246,FALSE +"HCC2279","Pearson.est","glycogen synthase kinase inhibitor",-0.3433,-0.955,0.494,1204,0.595,"TWS.119, tideglusib, CHIR.98014",0.306273051076353,0.22548303427145,FALSE +"HCC2279","Pearson.est","growth factor receptor inhibitor",0.62593,1.45,0.0783,368,0.242,"danusertib, AZD3463, GSK1838705A, lestaurtinib",1.10623823794206,0.616184634019569,FALSE +"HCC2279","Pearson.est","HCV inhibitor",0.41052,0.944,0.552,597,0.741,"mericitabine, Ro.9187, narlaprevir, embelin",0.258060922270801,0.130181792020672,FALSE +"HCC2279","Pearson.est","HDAC inhibitor",0.6752,1.54,0.0325,189,0.196,"M.344, R306465, givinostat, resminostat, SB.939, scriptaid, PCI.24781, RGFP966, chidamide, dacinostat, AR.42, entinostat, trichostatin.a, vorinostat, belinostat",1.48811663902113,0.707743928643524,TRUE +"HCC2279","Pearson.est","histamine receptor antagonist",-0.27692,-0.823,0.706,396,0.694,"cyproheptadine, levocetirizine, tiotidine, astemizole, ebastine, pheniramine, epinastine, chloropyramine, terfenadine, ICI.162846, famotidine, ranitidine, BF2.649, lafutidine, tecastemizole, nizatidine, cimetidine, zolantidine",0.151195298948196,0.158640529545145,FALSE +"HCC2279","Pearson.est","HMGCR inhibitor",-0.79404,-2.26,0.00549,1145,0.0174,"atorvastatin, mevastatin, simvastatin, lovastatin, pitavastatin, fluvastatin",2.26042765554991,1.7594507517174,TRUE +"HCC2279","Pearson.est","HSP inhibitor",0.59258,1.36,0.113,565,0.368,"NMS.E973, tanespimycin, XL888, alvespimycin, BIIB021, NVP.AUY922, PU.H71, SNX.5422, ganetespib, SNX.2112, VER.49009",0.94692155651658,0.434152181326482,FALSE +"HCC2279","Pearson.est","JAK inhibitor",0.60092,1.38,0.106,426,0.347,"pacritinib, AT.9283, TG.02, tozasertib, TG.101348, AZ960, TG.101209, PRT062070, lestaurtinib, LY2784544",0.97469413473523,0.459670525209126,FALSE +"HCC2279","Pearson.est","KIT inhibitor",0.42677,0.972,0.531,472,0.76,"sorafenib, pazopanib, regorafenib, OSI.930, imatinib, vatalanib, sunitinib, lenvatinib, cediranib, motesanib",0.274905478918531,0.119186407719209,FALSE +"HCC2279","Pearson.est","MDM inhibitor",0.45397,1.04,0.423,595,0.734,"serdemetan, nutlin.3, RITA",0.373659632624958,0.134303940083929,FALSE +"HCC2279","Pearson.est","MEK inhibitor",-0.45252,-1.31,0.194,1067,0.272,"PD.0325901, cobimetinib, AZD8330, selumetinib, PD.184352, Ro.4987655, TAK.733, PD.318088, PD.198306, refametinib, MEK1.2.inhibitor",0.712198270069774,0.565431095965801,FALSE +"HCC2279","Pearson.est","MET inhibitor",-0.47708,-1.38,0.156,1435,0.275,"PF.04217903",0.806875401645538,0.560667306169737,FALSE +"HCC2279","Pearson.est","microtubule inhibitor",0.57984,1.33,0.131,340,0.371,"vinflunine, D.64131, podophyllotoxin, cabazitaxel, vinblastine",0.882728704344236,0.430626090384954,FALSE +"HCC2279","Pearson.est","mTOR inhibitor",0.46034,1.05,0.413,573,0.731,"WYE.125132, torin.2, GSK2126458, PF.05212384, AZD2014, GDC.0980, PKI.179, XL388, AZD8055, PI.103, deforolimus, voxtalisib, MLN0128, everolimus, temsirolimus, WYE.354, PP242, ku.0063794",0.384049948343599,0.13608262304214,FALSE +"HCC2279","Pearson.est","NFkB pathway inhibitor",0.52594,1.24,0.202,254,0.457,"EVP4593, curcumin, parthenolide...., Ro.106.9920, betulinic.acid",0.694648630553376,0.34008379993015,FALSE +"HCC2279","Pearson.est","opioid receptor agonist",-0.52129,-1.46,0.106,1158,0.263,"spiradoline, ADL5859, BW.180C",0.97469413473523,0.580044251510242,FALSE +"HCC2279","Pearson.est","p38 MAPK inhibitor",0.32344,0.756,0.793,690,0.935,"talmapimod, SB.239063, skepinone.l, CMPD.1, SB.242235",0.100726812682396,0.0291883891274822,FALSE +"HCC2279","Pearson.est","PARP inhibitor",0.70994,1.65,0.0183,177,0.179,"niraparib, talazoparib, olaparib, PJ.34",1.73754891026957,0.747146969020107,TRUE +"HCC2279","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.43126,0.987,0.486,472,0.75,"sorafenib, pazopanib, regorafenib, axitinib, imatinib, dovitinib, trapidil, vatalanib, crenolanib, sunitinib, lenvatinib, motesanib",0.313363730737707,0.1249387366083,FALSE +"HCC2279","Pearson.est","phosphatase inhibitor",0.43126,0.995,0.491,391,0.753,"mycophenolate.mofetil, mycophenolic.acid, CID.5458317, GSK2830371",0.308918507877032,0.123205023799299,FALSE +"HCC2279","Pearson.est","phosphodiesterase inhibitor",-0.33308,-0.967,0.436,1149,0.608,"YM.976, EMD.53998, enoximone, GSK256066, anagrelide",0.360513510731414,0.216096420727265,FALSE +"HCC2279","Pearson.est","PI3K inhibitor",0.52239,1.21,0.232,444,0.448,"CUDC.907, taselisib, buparlisib, GSK2126458, PF.05212384, PI3K.IN.2, alpelisib, YM.201636, GDC.0980, BGT226, CH5132799, PIK.75, PKI.179, PI.103, voxtalisib",0.6345120151091,0.348721986001856,FALSE +"HCC2279","Pearson.est","PLK inhibitor",0.75434,1.75,0.00864,361,0.116,"volasertib, GW.843682X, NMS.1286937, BI.2536, rigosertib, GSK461364, HMN.214",2.06348625752111,0.935542010773082,TRUE +"HCC2279","Pearson.est","potassium channel blocker",-0.37897,-1.1,0.281,1184,0.438,"dofetilide, mepivacaine, meglitinide",0.55129368009492,0.3585258894959,FALSE +"HCC2279","Pearson.est","PPAR receptor agonist",0.22876,0.528,0.96,244,1,"ciprofibrate",0.0177287669604316,0,FALSE +"HCC2279","Pearson.est","progesterone receptor agonist",-0.53931,-1.56,0.0503,1156,0.208,"norgestrel, nomegestrol.acetate, danazol, norethindrone.acetate",1.29843201494407,0.681936665037238,FALSE +"HCC2279","Pearson.est","proteasome inhibitor",0.43293,0.998,0.479,736,0.767,"MG.132, carfilzomib, bortezomib, oprozomib, ONX.0914, delanzomib",0.319664486585437,0.115204636051019,FALSE +"HCC2279","Pearson.est","protein synthesis inhibitor",0.5547,1.28,0.167,33,0.432,"anguidine, homoharringtonine, bruceantin, harringtonine",0.777283528852417,0.364516253185088,FALSE +"HCC2279","Pearson.est","protein tyrosine kinase inhibitor",0.57957,1.34,0.12,200,0.37,"NVP.TAE226, tyrphostin.A9, mubritinib",0.920818753952375,0.431798275933005,FALSE +"HCC2279","Pearson.est","RAF inhibitor",0.57877,1.34,0.125,217,0.37,"sorafenib, regorafenib, TAK.632, RAF265, SB.590885",0.903089986991944,0.431798275933005,FALSE +"HCC2279","Pearson.est","RET tyrosine kinase inhibitor",0.66804,1.54,0.0254,49,0.196,"sorafenib, regorafenib",1.59516628338006,0.707743928643524,TRUE +"HCC2279","Pearson.est","retinoid receptor agonist",0.63515,1.46,0.0602,231,0.242,"adarotene, fenretinide, bexarotene",1.22040350874218,0.616184634019569,FALSE +"HCC2279","Pearson.est","ribonucleotide reductase inhibitor",0.52707,1.22,0.216,548,0.461,"clofarabine, cladribine, LY2334737, gemcitabine, pentostatin, fludarabine.phosphate, fludarabine",0.665546248849069,0.336299074610352,FALSE +"HCC2279","Pearson.est","serotonin receptor agonist",0.25867,0.599,0.933,661,1,"aripiprazole, pardoprunox, zolmitriptan",0.0301183562535,0,FALSE +"HCC2279","Pearson.est","serotonin receptor antagonist",0.38468,0.871,0.668,609,0.815,"sertindole, lurasidone, aripiprazole, paliperidone, SB.228357, SB.200646, SB.216641",0.175223537524454,0.0888423912600234,FALSE +"HCC2279","Pearson.est","sodium channel blocker",0.42276,0.969,0.539,386,0.729,"benzethonium, lappaconite, brivaracetam, triamterene, ajmaline",0.268411234813261,0.137272471682025,FALSE +"HCC2279","Pearson.est","src inhibitor",-0.49623,-1.45,0.101,1401,0.247,"saracatinib, dasatinib",0.995678626217357,0.607303046740334,FALSE +"HCC2279","Pearson.est","sterol demethylase inhibitor",-0.33954,-0.935,0.461,1243,0.596,"sulconazole, terconazole, lanoconazole",0.336299074610352,0.224753740259764,FALSE +"HCC2279","Pearson.est","TGF beta receptor inhibitor",-0.46117,-1.31,0.175,665,0.272,"adaprev, D.4476, SB.431542, SB.525334, LY2109761, repsox",0.756961951313706,0.565431095965801,FALSE +"HCC2279","Pearson.est","thymidylate synthase inhibitor",0.62897,1.46,0.0703,405,0.242,"raltitrexed, trifluridine, carmofur, doxifluridine",1.15304467498018,0.616184634019569,FALSE +"HCC2279","Pearson.est","topoisomerase inhibitor",0.69351,1.6,0.025,311,0.196,"topotecan, epirubicin, etoposide.phosphate, idarubicin, doxorubicin, irinotecan, daunorubicin, valrubicin, exatecan.mesylate, genz.644282, TAS.103, amsacrine, beta.lapachone, SN.38, voreloxin, teniposide, rubitecan, nemorubicin, amonafide, etoposide",1.60205999132796,0.707743928643524,TRUE +"HCC2279","Pearson.est","tubulin polymerization inhibitor",0.72947,1.69,0.0145,340,0.159,"albendazole, taltobulin, fosbretabulin, vindesine, vincristine, vinorelbine, combretastatin.A.4, parbendazole, KX2.391, docetaxel, nocodazole, verubulin, indibulin, paclitaxel, ABT.751, podophyllotoxin, CYT.997, mebendazole, dolastatin.10, fenbendazole, BNC105, flubendazole, plinabulin, vinblastine",1.83863199776503,0.798602875679548,TRUE +"HCC2279","Pearson.est","tyrosine kinase inhibitor",0.41738,0.966,0.527,262,0.718,"sorafenib, regorafenib, tivantinib, NVP.TAE226, tyrphostin.A9, UNC2250, mubritinib, bafetinib",0.278189384787453,0.1438755557577,FALSE +"HCC2279","Pearson.est","VEGFR inhibitor",0.52843,1.21,0.227,523,0.448,"sorafenib, pazopanib, regorafenib, golvatinib, OSI.930, RAF265, axitinib, ENMD.2076, lucitanib, foretinib, dovitinib, vatalanib, sunitinib, lenvatinib, TG.100572, cediranib, motesanib, tivozanib, PD.173074, cabozantinib, AEE788",0.643974142806877,0.348721986001856,FALSE +"HCC2279","Pearson.est","vitamin D receptor agonist",0.43234,1,0.457,825,0.784,"maxacalcitol, tacalcitol, doxercalciferol, alfacalcidol, paricalcitol, ercalcitriol, calcitriol",0.34008379993015,0.105683937315562,FALSE +"H520","Pearson.est","EGFR inhibitor",-0.4739,-1.11,0.327,969,0.639,"BMS.599626, pelitinib, PD.168393, rociletinib, BIBU.1361, tyrphostin.AG.1478, BIBX.1382, erlotinib, gefitinib, dacomitinib, canertinib, CUDC.101, osimertinib, AZD8931, CNX.2006, WZ.4002, WZ.3146, lapatinib, afatinib, ARRY.334543, neratinib, poziotinib, tucatinib, CP.724714, AST.1306",0.485452247339714,0.1944991418416,FALSE +"H520","Pearson.est","Abl kinase inhibitor",0.55468,1.51,0.0857,182,0.258,"dasatinib, ponatinib, metatinib, bafetinib",1.0670191780768,0.58838029403677,FALSE +"H520","Pearson.est","acetylcholine receptor agonist",-0.44403,-1.06,0.388,1076,0.698,"pilocarpine, oxiracetam, xanomeline",0.411168274405793,0.156144577376839,FALSE +"H520","Pearson.est","acetylcholine receptor antagonist",0.40135,1.13,0.267,227,0.58,"dicycloverine, methscopolamine, iododexetimide",0.573488738635425,0.236572006437063,FALSE +"H520","Pearson.est","adenosine receptor antagonist",-0.51294,-1.21,0.236,1064,0.631,"SCH.58261, CGS.15943, MRS.1220",0.627087997029893,0.199970640755866,FALSE +"H520","Pearson.est","adrenergic receptor agonist",0.49324,1.42,0.107,98,0.325,"ritodrine, oxymetazoline, clenbuterol, terbutaline",0.97061622231479,0.488116639021126,FALSE +"H520","Pearson.est","adrenergic receptor antagonist",-0.33073,-0.772,0.78,719,0.945,"oxprenolol, atipamezole, vincamine, dronedarone, imiloxan, propranolol, dihydroergocristine, naftidrofuryl, RS.17053, prazosin",0.10790539730952,0.0245681914907371,FALSE +"H520","Pearson.est","AKT inhibitor",-0.5733,-1.35,0.131,991,0.497,"ONC201, GDC.0068, A.674563, AZD5363, AT7867, uprosertib, GSK2110183",0.882728704344236,0.303643611266668,FALSE +"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.34743,0.953,0.467,167,0.766,"GW.788388, CEP.37440, crizotinib, lorlatinib",0.330683119433888,0.115771230367396,FALSE +"H520","Pearson.est","androgen receptor antagonist",0.54109,1.58,0.0821,216,0.335,"bicalutamide, cyproterone.acetate, RU.58841",1.08565684288056,0.474955192963155,FALSE +"H520","Pearson.est","antioxidant",0.53883,1.52,0.0512,671,0.311,"taurine, chlorogenic.acid, benfotiamine, trolox, mesna, rutin",1.29073003902417,0.507239610973163,FALSE +"H520","Pearson.est","AP inhibitor",-0.47909,-1.14,0.303,1417,0.648,"tanshinone.i",0.518557371497695,0.188424994129407,FALSE +"H520","Pearson.est","ATPase inhibitor",-0.46542,-1.1,0.352,1126,0.637,"rabeprazole, evodiamine, NMS.873, oligomycin.a",0.453457336521869,0.19586056766465,FALSE +"H520","Pearson.est","Aurora kinase inhibitor",-0.66809,-1.59,0.0352,1212,0.267,"PF.03814735, CCT137690, AMG900, GSK1070916, alisertib, MK.8745, CYC116, TAK.901, ZM.447439, AT.9283, barasertib.HQPA, SNS.314, danusertib, PHA.680632",1.45345733652187,0.573488738635425,FALSE +"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.24789,-0.577,0.949,1198,0.981,"radezolid, josamycin",0.0227337875727074,0.0083309926200515,FALSE +"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.35553,1.01,0.376,52,0.692,"sparfloxacin, novobiocin",0.424812155072339,0.159893905543242,FALSE +"H520","Pearson.est","BCL inhibitor",0.28472,0.823,0.677,1038,0.918,"HA14.1, navitoclax, oridonin, gossypol, ABT.737, TW.37, obatoclax, venetoclax",0.169411331314856,0.0371573187987575,FALSE +"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.70626,2.04,0.0243,182,0.152,"dasatinib, ponatinib, metatinib, bafetinib",1.61439372640169,0.818156412055227,TRUE +"H520","Pearson.est","benzodiazepine receptor agonist",0.1742,0.481,0.986,122,1,"temazepam, eprinomectin",0.0061230850587888,0,FALSE +"H520","Pearson.est","bromodomain inhibitor",-0.8086,-1.91,0.00127,1166,0.0676,"bromosporine, PFI.1, I.BET.762, JQ1...., I.BET151, OTX015",2.89619627904404,1.17005330405836,TRUE +"H520","Pearson.est","calcium channel blocker",-0.43963,-1.04,0.391,687,0.717,"cinnarazine, SKF.96365, efonidipine.monoethanolate, SR.33805, tetrandrine, carboxyamidotriazole, mibefradil, fendiline",0.407823242604133,0.1444808443322,FALSE +"H520","Pearson.est","CC chemokine receptor antagonist",-0.39619,-0.949,0.521,1152,0.783,"ZK811752, SB.225002",0.283162276700476,0.106238237942057,FALSE +"H520","Pearson.est","CDK inhibitor",-0.53282,-1.25,0.193,899,0.6,"palbociclib, kenpaullone, dinaciclib, TG.02, CR8..R., indirubin, BMS.265246, ribociclib, JNJ.7706621, AT.7519, BMS.387032, indisulam, arcyriaflavin.a, R547, PHA.793887",0.714442690992226,0.221848749616356,FALSE +"H520","Pearson.est","CHK inhibitor",0.55817,1.62,0.0718,231,0.354,"SCH.900776, LY2606368, LY2603618, AZD7762",1.1438755557577,0.450996737974212,FALSE +"H520","Pearson.est","cyclooxygenase inhibitor",-0.3222,-0.777,0.745,929,0.962,"curcumin, FK.3311, piroxicam, tryptanthrin, AM.404, FR.122047, aspirin, amfenac, naproxen",0.127843727251707,0.0168249279621871,FALSE +"H520","Pearson.est","cytochrome P450 inhibitor",0.59016,1.66,0.0605,295,0.375,"itraconazole, eplerenone, clotrimazole, metyrapone",1.21824462534753,0.425968732272281,FALSE +"H520","Pearson.est","DNA alkylating agent",0.17691,0.474,0.99,228,0.99,"cisplatin, carmustine, estramustine, dacarbazine",0.00436480540245009,0.00436480540245009,FALSE +"H520","Pearson.est","DNA inhibitor",-0.29622,-0.702,0.849,927,0.95,"teroxirone, pibenzimol, valrubicin, bendamustine, mechlorethamine, busulfan, primaquine, oxaliplatin",0.0710923097560473,0.0222763947111523,FALSE +"H520","Pearson.est","DNA methyltransferase inhibitor",-0.47213,-1.11,0.363,960,0.639,"disulfiram, azacitidine, SGI.1027, fdcyd",0.440093374963888,0.1944991418416,FALSE +"H520","Pearson.est","DNA polymerase inhibitor",-0.39409,-0.938,0.553,815,0.782,"idoxuridine, famciclovir, cidofovir, trifluridine, cephalomannine",0.257274868695302,0.106793246940152,FALSE +"H520","Pearson.est","DNA synthesis inhibitor",-0.36723,-0.879,0.624,1299,0.841,"artemisinin, mitomycin.c, floxuridine",0.204815410317576,0.0752040042020878,FALSE +"H520","Pearson.est","dopamine receptor antagonist",-0.47507,-1.14,0.289,877,0.648,"domperidone, acetophenazine, lurasidone, isofloxythepin, oxiperomide, sertindole, clebopride, UH.232...., remoxipride, thioproperazine",0.539102157243452,0.188424994129407,FALSE +"H520","Pearson.est","estrogen receptor agonist",0.27235,0.774,0.75,23,0.972,"estradiol",0.1249387366083,0.0123337350737254,FALSE +"H520","Pearson.est","estrogen receptor antagonist",-0.64022,-1.51,0.0562,1136,0.269,"tamoxifen, raloxifene, clomifene",1.25026368443094,0.570247719997592,FALSE +"H520","Pearson.est","FGFR inhibitor",0.55896,1.57,0.0704,312,0.297,"erdafitinib, MK.2461, dovitinib, nintedanib, AZD4547",1.15242734085789,0.527243550682788,FALSE +"H520","Pearson.est","FLT3 inhibitor",0.24133,0.707,0.822,54,0.974,"ponatinib, gilteritinib",0.0851281824599496,0.0114410431213845,FALSE +"H520","Pearson.est","glucocorticoid receptor agonist",-0.62488,-1.47,0.0557,1100,0.283,"desonide, fludroxycortide, triamcinolone, difluprednate, fluticasone.propionate, methylprednisolone, halobetasol.propionate, ciclesonide, dexamethasone.acetate, triamcinolone.acetonide, prednisolone, rimexolone, deflazacort, halcinonide, flumethasone.pivalate, betamethasone, hydrocortisone",1.25414480482627,0.54821356447571,FALSE +"H520","Pearson.est","glutamate receptor antagonist",-0.32414,-0.762,0.785,1400,0.938,"ACDPP, IEM1754",0.105130343254747,0.0277971616209356,FALSE +"H520","Pearson.est","glycogen synthase kinase inhibitor",0.23211,0.652,0.905,1114,0.945,"CHIR.98014, tideglusib, TWS.119, AZD2858, GSK.3.inhibitor.IX, LY2090314, CHIR.99021, kenpaullone, indirubin",0.0433514207947967,0.0245681914907371,FALSE +"H520","Pearson.est","growth factor receptor inhibitor",-0.64264,-1.57,0.0369,1150,0.203,"GSK1904529A, lestaurtinib, GW.441756, danusertib",1.43297363384094,0.692503962086787,TRUE +"H520","Pearson.est","HCV inhibitor",0.26068,0.731,0.829,34,0.972,"Ro.9187",0.0814454694497265,0.0123337350737254,FALSE +"H520","Pearson.est","HDAC inhibitor",-0.41168,-0.99,0.485,937,0.726,"R306465, pyroxamide, PCI.24781, trichostatin.a, M.344, scriptaid, vorinostat, NSC.3852, nexturastat.a, SB.939, RGFP966, ACY.1215",0.314258261397736,0.139063379299906,FALSE +"H520","Pearson.est","histamine receptor antagonist",-0.2545,-0.607,0.93,1026,1,"epinastine, chloropyramine, astemizole, ebastine, terfenadine, levocetirizine",0.0315170514460649,0,FALSE +"H520","Pearson.est","HMGCR inhibitor",0.60423,1.76,0.0372,82,0.344,"lovastatin, pitavastatin",1.4294570601181,0.46344155742847,FALSE +"H520","Pearson.est","HSP inhibitor",-0.42905,-1.02,0.435,1155,0.735,"alvespimycin, KW.2478, XL888, tanespimycin",0.361510743045363,0.133712660915805,FALSE +"H520","Pearson.est","JAK inhibitor",-0.46602,-1.11,0.331,951,0.639,"CEP.33779, TG.02, WHI.P154, pacritinib, AZ960, LY2784544, atiprimod, lestaurtinib, filgotinib, AT.9283",0.480172006224281,0.1944991418416,FALSE +"H520","Pearson.est","KIT inhibitor",0.34408,0.952,0.466,25,0.731,"dasatinib, telatinib",0.33161408331,0.13608262304214,FALSE +"H520","Pearson.est","MDM inhibitor",-0.7337,-1.73,0.0138,1058,0.262,"serdemetan, AMG.232, RITA, idasanutlin, nutlin.3, CGM097",1.86012091359876,0.581698708680255,FALSE +"H520","Pearson.est","MEK inhibitor",-0.18988,-0.443,0.986,572,0.992,"arctigenin, trametinib, selumetinib, MEK1.2.inhibitor, AZD8330, TAK.733, AS.703026, MEK162, U.0126, PD.98059, PD.318088, Ro.4987655, PD.0325901, PD.198306",0.0061230850587888,0.00348832784582135,FALSE +"H520","Pearson.est","MET inhibitor",0.78849,2.27,0.00508,311,0.0551,"LY2801653, PHA.665752, PF.04217903, INC.280, NVP.BVU972, AMG458",2.29413628771608,1.25884840114821,TRUE +"H520","Pearson.est","microtubule inhibitor",-0.49083,-1.18,0.261,1209,0.674,"colchicine, podophyllotoxin, D.64131, cabazitaxel",0.583359492661719,0.17134010346468,FALSE +"H520","Pearson.est","mTOR inhibitor",-0.30897,-0.725,0.827,753,0.965,"PI.103, torin.1, ku.0063794, voxtalisib, torin.2, AZD2014, deforolimus, PF.04691502, PKI.179, WAY.600, XL388, WYE.125132, GSK2126458, LY303511, PF.05212384, AZD8055",0.0824944904474534,0.0154726866562074,FALSE +"H520","Pearson.est","NFkB pathway inhibitor",-0.53228,-1.25,0.205,1282,0.6,"bindarit, parthenolide...., IKK.2.inhibitor.V, EVP4593",0.688246138944246,0.221848749616356,FALSE +"H520","Pearson.est","opioid receptor agonist",0.4362,1.24,0.225,819,0.551,"BW.180C, salvinorin.a, spiradoline, trimebutine, ADL5859, cebranopadol",0.647817481888638,0.258848401148215,FALSE +"H520","Pearson.est","p38 MAPK inhibitor",-0.71449,-1.7,0.0115,1184,0.166,"skepinone.l, CMPD.1, SB.239063, talmapimod",1.93930215964639,0.779891911959945,TRUE +"H520","Pearson.est","PARP inhibitor",-0.37099,-0.884,0.609,1120,0.855,"AG.14361, niraparib, PJ.34",0.215382707367125,0.0680338852718274,FALSE +"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.52052,1.51,0.0989,169,0.258,"dasatinib, ponatinib, telatinib, CP.673451, motesanib, dovitinib",1.00480370840282,0.58838029403677,FALSE +"H520","Pearson.est","phosphatase inhibitor",0.39743,1.12,0.299,66,0.563,"BVT.948, bis.maltolato.oxovanadium.IV.",0.52432881167557,0.249491605148654,FALSE +"H520","Pearson.est","phosphodiesterase inhibitor",0.40934,1.16,0.241,16,0.603,"YM.976, GSK256066",0.617982957425132,0.219682687859849,FALSE +"H520","Pearson.est","PI3K inhibitor",-0.3075,-0.724,0.823,984,0.945,"PF.04691502, alpelisib, PKI.179, YM.201636, AZD6482, CUDC.907, GSK2126458, LY303511, PIK.75, PF.05212384, taselisib",0.0846001647877302,0.0245681914907371,FALSE +"H520","Pearson.est","PLK inhibitor",-0.66025,-1.57,0.0375,1253,0.203,"GW.843682X, NMS.1286937, HMN.214",1.42596873227228,0.692503962086787,TRUE +"H520","Pearson.est","potassium channel blocker",0.32986,0.92,0.528,181,0.759,"mepivacaine, dofetilide",0.277366077466188,0.11975822410452,FALSE +"H520","Pearson.est","PPAR receptor agonist",-0.34944,-0.839,0.668,999,0.887,"oleoylethanolamide, ciprofibrate, GW.501516",0.175223537524454,0.0520763801682736,FALSE +"H520","Pearson.est","progesterone receptor agonist",-0.20882,-0.488,0.971,1082,1,"tanaproget, levonorgestrel",0.0127807700919951,0,FALSE +"H520","Pearson.est","proteasome inhibitor",-0.52142,-1.23,0.217,902,0.617,"ixazomib, ONX.0914, delanzomib, oprozomib, ixazomib.citrate, MG.132",0.66354026615147,0.209714835966758,FALSE +"H520","Pearson.est","protein synthesis inhibitor",-0.54336,-1.29,0.172,956,0.612,"tedizolid.phosphate, thiostrepton, clofoctol, chloramphenicol.palmitate, methacycline, azomycin..2.nitroimidazole., homoharringtonine, anguidine, cycloheximide, harringtonine, puromycin, bruceantin",0.764471553092451,0.213248577854439,FALSE +"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.54195,-1.28,0.174,964,0.599,"PP.121, BMS.599626, NVP.TAE226, AV.412, mubritinib, CP.724714",0.7594507517174,0.222573177610689,FALSE +"H520","Pearson.est","RAF inhibitor",-0.47818,-1.14,0.304,755,0.648,"LGX818, sorafenib, RAF265, TAK.632, vemurafenib, GDC.0879, AZ.628, CEP.32496, PLX.4720",0.517126416391246,0.188424994129407,FALSE +"H520","Pearson.est","RET tyrosine kinase inhibitor",0.38626,1.13,0.26,26,0.58,"vandetanib",0.585026652029182,0.236572006437063,FALSE +"H520","Pearson.est","retinoid receptor agonist",-0.41996,-0.998,0.466,1401,0.733,"bexarotene",0.33161408331,0.134896025358872,FALSE +"H520","Pearson.est","ribonucleotide reductase inhibitor",0.24757,0.696,0.847,1092,0.956,"fludarabine, hydroxyurea, pentostatin, fludarabine.phosphate, triapine, clofarabine, cytarabine, LY2334737, cladribine, gemcitabine",0.0721165896692931,0.0195421077238999,FALSE +"H520","Pearson.est","serotonin receptor agonist",-0.65895,-1.57,0.0357,1447,0.203,"aripiprazole",1.44733178388781,0.692503962086787,TRUE +"H520","Pearson.est","serotonin receptor antagonist",-0.48779,-1.15,0.294,1180,0.715,"SB.228357, sertindole, aripiprazole",0.531652669587843,0.145693958198919,FALSE +"H520","Pearson.est","sodium channel blocker",-0.4294,-0.998,0.464,1034,0.733,"A.803467, benzocaine, brivaracetam, mexiletine, benzethonium",0.333482019445119,0.134896025358872,FALSE +"H520","Pearson.est","src inhibitor",0.39621,1.16,0.25,83,0.603,"dasatinib, PP.1",0.602059991327962,0.219682687859849,FALSE +"H520","Pearson.est","sterol demethylase inhibitor",0.25867,0.739,0.761,1075,0.996,"terconazole, ketoconazole, lanoconazole, sulconazole, posaconazole, chlormidazole",0.118615343229427,0.00174066157630127,FALSE +"H520","Pearson.est","TGF beta receptor inhibitor",-0.68568,-1.62,0.0223,1382,0.256,"D.4476, SB.525334",1.65169513695184,0.59176003468815,FALSE +"H520","Pearson.est","thymidylate synthase inhibitor",-0.62398,-1.48,0.057,1094,0.291,"carmofur, trifluridine, raltitrexed",1.24412514432751,0.536107011014093,FALSE +"H520","Pearson.est","topoisomerase inhibitor",-0.26563,-0.641,0.88,819,0.993,"etoposide.phosphate, licochalcone.a, teniposide, amsacrine, doxorubicin, etoposide, valrubicin, SN.38, amonafide, dexrazoxane, exatecan.mesylate, epirubicin, TAS.103, voreloxin",0.0555173278498314,0.00305075150461883,FALSE +"H520","Pearson.est","tubulin polymerization inhibitor",-0.72364,-1.72,0.00768,1281,0.192,"podophyllotoxin, flubendazole, combretastatin.A.4, mebendazole, albendazole, dolastatin.10, parbendazole, plinabulin, vinorelbine, epothilone.b, KX2.391, CYT.997, indibulin, nocodazole, taltobulin, ABT.751, vincristine",2.11463877996849,0.71669877129645,TRUE +"H520","Pearson.est","tyrosine kinase inhibitor",-0.24902,-0.591,0.922,936,0.992,"tyrphostin.AG.99, PP.121, BMS.599626, NVP.TAE226, apatinib, UNC2250, AV.412, mubritinib, GTP.14564, CP.724714",0.0352690789463706,0.00348832784582135,FALSE +"H520","Pearson.est","VEGFR inhibitor",0.23028,0.656,0.896,212,0.973,"foretinib, telatinib, vandetanib, MK.2461, motesanib, dovitinib, MGCD.265, tivozanib",0.0476919903378748,0.0118871597316481,FALSE +"H520","Pearson.est","vitamin D receptor agonist",0.36711,1.02,0.406,919,0.71,"maxacalcitol, calcitriol, alfacalcidol, tacalcitol, paricalcitol, doxercalciferol, ercalcitriol",0.391473966422806,0.148741651280925,FALSE +"HCC15","Pearson.est","EGFR inhibitor",0.41751,0.978,0.491,661,0.68,"CUDC.101, TAK.285, tucatinib, GW.583340, WZ.4002, BIBU.1361, afatinib, AEE788, XL.647, rociletinib, osimertinib, ARRY.334543, CP.724714, lapatinib, PD.153035, AZD8931, neratinib, WZ8040, OSI.420, dovitinib, AST.1306, BIBX.1382, dacomitinib, BMS.690514, vandetanib, poziotinib, gefitinib",0.308918507877032,0.167491087293764,FALSE +"HCC15","Pearson.est","Abl kinase inhibitor",0.38037,0.88,0.633,420,0.769,"tozasertib, bafetinib, imatinib, KW.2449, ponatinib",0.198596289982645,0.114073660198569,FALSE +"HCC15","Pearson.est","acetylcholine receptor agonist",-0.4466,-1.26,0.184,644,0.515,"pilocarpine, oxiracetam, nefiracetam, xanomeline, nicotine, tremorine",0.735182176990464,0.288192770958809,FALSE +"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.35919,-1,0.406,1088,0.662,"darifenacin, hyoscyamine, iododexetimide, dicycloverine, methscopolamine",0.391473966422806,0.1791420105603,FALSE +"HCC15","Pearson.est","adenosine receptor antagonist",0.54429,1.26,0.185,518,0.509,"CGS.15943, MRS.1220, PSB.1115, SCH.58261, theophylline",0.732828271596986,0.293282217663241,FALSE +"HCC15","Pearson.est","adrenergic receptor agonist",-0.21144,-0.621,0.957,303,1,"ritodrine, metaraminol, buphenine, clenbuterol, isoetharine, midodrine, terbutaline, norepinephrine, lidamidine, isoxsuprine, A61603, oxymetazoline, methyldopa, epinephrine, xylazine",0.0190880622231565,0,FALSE +"HCC15","Pearson.est","adrenergic receptor antagonist",0.32081,0.75,0.774,411,0.873,"atipamezole, oxprenolol, dihydroergocristine, practolol, vincamine, atenolol......",0.111259039317107,0.0589857562944303,FALSE +"HCC15","Pearson.est","AKT inhibitor",0.68003,1.56,0.0267,234,0.227,"uprosertib, GDC.0068, A.674563, AZD5363, MK.2206, GSK2110183, ONC201",1.57348873863542,0.643974142806877,TRUE +"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.4623,1.07,0.39,208,0.636,"DMH1, CEP.37440, AZD3463, crizotinib",0.408935392973501,0.196542884351586,FALSE +"HCC15","Pearson.est","androgen receptor antagonist",-0.77199,-2.18,0,1195,0.0275,"nilutamide, cyproterone.acetate, enzalutamide, flutamide",Inf,1.56066730616974,TRUE +"HCC15","Pearson.est","antioxidant",-0.40499,-1.18,0.198,584,0.465,"chlorogenic.acid, trolox, benfotiamine, taurine, mesna, rutin",0.703334809738469,0.332547047110046,FALSE +"HCC15","Pearson.est","AP inhibitor",-0.84798,-2.26,0,1351,0.0189,"idronoxil, birinapant, LCL.161, GDC.0152",Inf,1.72353819582676,TRUE +"HCC15","Pearson.est","ATPase inhibitor",-0.37367,-1.03,0.401,1403,0.697,"digitoxigenin, digitoxin, ouabain, k.strophanthidin",0.396855627379818,0.156767221901991,FALSE +"HCC15","Pearson.est","Aurora kinase inhibitor",0.69245,1.59,0.0235,395,0.208,"barasertib, tozasertib, CCT137690, ZM.447439, aurora.a.inhibitor.i, barasertib.HQPA, AMG900, hesperadin, SNS.314, MK.8745, CCT129202, PHA.680632, danusertib, ENMD.2076, AT.9283, KW.2449, alisertib, TAK.901, GSK1070916",1.62893213772826,0.681936665037238,TRUE +"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.51891,1.21,0.237,621,0.604,"valnemulin, azalomycin.b, azithromycin, dirithromycin, tedizolid",0.625251653989896,0.218963061378868,FALSE +"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.25871,0.603,0.927,475,0.947,"novobiocin, nadifloxacin",0.0329202658555029,0.0236500209967266,FALSE +"HCC15","Pearson.est","BCL inhibitor",0.60108,1.4,0.0941,436,0.348,"gossypol, TW.37, oridonin, obatoclax, HA14.1",1.02641037657274,0.458420756053419,FALSE +"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",0.39374,0.89,0.643,61,0.77,"tozasertib, bafetinib",0.191789027075778,0.113509274827518,FALSE +"HCC15","Pearson.est","benzodiazepine receptor agonist",0.36692,0.855,0.676,353,0.793,"ivermectin, ZK.93423, zaleplon, piperazine",0.170053304058364,0.100726812682396,FALSE +"HCC15","Pearson.est","bromodomain inhibitor",0.90985,2.12,0.00126,136,0.00169,"I.BET151, JQ1...., OTX015, I.BET.762, bromosporine, PFI.1",2.89962945488244,2.77211329538633,TRUE +"HCC15","Pearson.est","calcium channel blocker",0.51684,1.2,0.215,545,0.602,"carboxyamidotriazole, mibefradil, penfluridol, SR.33805, pranidipine, tetrandrine, fendiline",0.667561540084395,0.220403508742175,FALSE +"HCC15","Pearson.est","CC chemokine receptor antagonist",0.6147,1.43,0.0775,177,0.314,"ZK811752, PF.04136309, SB.225002",1.11069829749369,0.503070351926785,FALSE +"HCC15","Pearson.est","CDK inhibitor",0.63411,1.46,0.0625,345,0.305,"indisulam, TG.02, palbociclib, abemaciclib, BMS.387032, ribociclib, P276.00, JNJ.7706621, arcyriaflavin.a, dinaciclib, AT.7519, R547, alvocidib, kenpaullone, aminopurvalanol.a",1.20411998265592,0.515700160653214,FALSE +"HCC15","Pearson.est","CHK inhibitor",0.28903,0.677,0.879,187,0.901,"SB.218078",0.0560111249262281,0.045275209020937,FALSE +"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.19552,-0.529,0.993,279,1,"curcumin, ketoprofen, aspirin, piroxicam, ramifenazone, tepoxalin, pterostilbene, meloxicam, FR.122047, tryptanthrin, suxibuzone, phenazone, indoprofen, naproxen, phenylbutazone, amfenac, FK.3311, sulfasalazine, acetylsalicylsalicylic.acid, metoxibutropate, AM.404",0.00305075150461883,0,FALSE +"HCC15","Pearson.est","cytochrome P450 inhibitor",-0.53195,-1.54,0.0714,1232,0.349,"itraconazole, clotrimazole, metyrapone, morin, eplerenone",1.14630178822383,0.45717457304082,FALSE +"HCC15","Pearson.est","DNA alkylating agent",0.44755,1.04,0.414,270,0.646,"mitomycin.c, estramustine, melphalan, TH.302, satraplatin",0.382999658879101,0.189767482004916,FALSE +"HCC15","Pearson.est","DNA inhibitor",0.58046,1.34,0.121,406,0.402,"melphalan, oxaliplatin, pibenzimol, primaquine, chlorambucil, valrubicin, metronidazole, teroxirone, mechlorethamine, bendamustine",0.91721462968355,0.39577394691553,FALSE +"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.79751,1.86,0.0049,238,0.0246,"fdcyd, azacitidine, decitabine, SGI.1027",2.30980391997149,1.60906489289662,TRUE +"HCC15","Pearson.est","DNA polymerase inhibitor",0.46033,1.07,0.392,438,0.636,"trifluridine, idoxuridine, adefovir.dipivoxil, cephalomannine, foscarnet",0.406713932979543,0.196542884351586,FALSE +"HCC15","Pearson.est","DNA synthesis inhibitor",0.47997,1.12,0.325,143,0.669,"cyclocytidine, mitomycin.c, anisomycin, artesunate, enocitabine",0.488116639021126,0.174573882232177,FALSE +"HCC15","Pearson.est","dopamine receptor antagonist",0.3083,0.73,0.829,91,0.879,"sertindole, lurasidone",0.0814454694497265,0.0560111249262281,FALSE +"HCC15","Pearson.est","estrogen receptor agonist",-0.30278,-0.859,0.605,436,0.733,"estradiol, equol, estrone, erteberel, PPT, ethinyl.estradiol, levonorgestrel, estradiol.cypionate",0.218244625347531,0.134896025358872,FALSE +"HCC15","Pearson.est","estrogen receptor antagonist",0.47995,1.11,0.33,195,0.648,"clomifene, fulvestrant",0.481486060122112,0.188424994129407,FALSE +"HCC15","Pearson.est","FGFR inhibitor",0.41964,0.981,0.499,530,0.691,"regorafenib, nintedanib, PD.173074, dovitinib, lucitanib",0.30189945437661,0.160521952625802,FALSE +"HCC15","Pearson.est","FLT3 inhibitor",0.58143,1.36,0.112,313,0.409,"sorafenib, tozasertib, pacritinib, TG.02, quizartinib, TG.101348, ENMD.2076, KW.2449",0.950781977329818,0.388276691992658,FALSE +"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.27288,-0.755,0.739,1312,0.87,"fluocinolone.acetonide, piretanide, dexamethasone.acetate, hydrocortisone",0.131355561605174,0.0604807473813815,FALSE +"HCC15","Pearson.est","glutamate receptor antagonist",-0.69175,-1.93,0.00505,1137,0.095,"MTPG, IEM1754, felbamate, diazooxonorleucine, CPP, tiletamine, kynurenic.acid, SIB.1757, latrepirdine, JNJ.16259685",2.29670862188134,1.02227639471115,TRUE +"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.42537,-1.21,0.223,1330,0.552,"CHIR.98014, tideglusib, indirubin",0.651695136951839,0.258060922270801,FALSE +"HCC15","Pearson.est","growth factor receptor inhibitor",0.63201,1.46,0.0539,260,0.305,"GSK1838705A, AZD3463, danusertib",1.26841123481326,0.515700160653214,FALSE +"HCC15","Pearson.est","HCV inhibitor",0.47425,1.11,0.333,617,0.648,"Ro.9187, mericitabine, PSI.7976",0.47755576649368,0.188424994129407,FALSE +"HCC15","Pearson.est","HDAC inhibitor",0.80156,1.87,0,226,0.0297,"R306465, givinostat, M.344, resminostat, scriptaid, dacinostat, AR.42, PCI.24781, chidamide, SB.939, belinostat, trichostatin.a, entinostat, vorinostat, panobinostat, pyroxamide, RG2833, RGFP966",Inf,1.52724355068279,TRUE +"HCC15","Pearson.est","histamine receptor antagonist",-0.18957,-0.525,0.98,1444,0.98,"zolantidine",0.00877392430750515,0.00877392430750515,FALSE +"HCC15","Pearson.est","HMGCR inhibitor",-0.83735,-2.36,0,1233,0.0206,"lovastatin, atorvastatin, mevastatin, pitavastatin, fluvastatin",Inf,1.68613277963085,TRUE +"HCC15","Pearson.est","HSP inhibitor",0.50298,1.16,0.277,505,0.648,"NMS.E973, NVP.AUY922, tanespimycin, SNX.5422, ganetespib, BIIB021, SNX.2112, XL888",0.557520230935551,0.188424994129407,FALSE +"HCC15","Pearson.est","JAK inhibitor",0.44892,1.03,0.45,318,0.648,"tozasertib, pacritinib, TG.02, TG.101348, AT.9283, PRT062070",0.346787486224656,0.188424994129407,FALSE +"HCC15","Pearson.est","KIT inhibitor",0.4637,1.07,0.389,355,0.636,"regorafenib, sorafenib, pazopanib, motesanib, imatinib, KI.8751, telatinib, OSI.930",0.410050398674292,0.196542884351586,FALSE +"HCC15","Pearson.est","MDM inhibitor",-0.30702,-0.878,0.542,1227,0.733,"CGM097, AMG.232, idasanutlin",0.266000713461613,0.134896025358872,FALSE +"HCC15","Pearson.est","MEK inhibitor",0.22585,0.516,0.981,826,0.975,"nobiletin, trametinib, arctigenin, AS.703026, cobimetinib, AZD8330, PD.0325901, TAK.733, U.0126, MEK162, selumetinib, PD.184352, Ro.4987655",0.0083309926200515,0.0109953843014632,FALSE +"HCC15","Pearson.est","MET inhibitor",-0.33681,-0.965,0.485,1393,0.69,"PF.04217903",0.314258261397736,0.161150909262745,FALSE +"HCC15","Pearson.est","microtubule inhibitor",0.43194,1,0.461,182,0.672,"D.64131, vinflunine",0.336299074610352,0.172630726946175,FALSE +"HCC15","Pearson.est","mTOR inhibitor",0.41699,0.965,0.515,738,0.689,"torin.2, WYE.125132, GSK2126458, PF.05212384, GDC.0980, AZD2014, everolimus, MLN0128, XL388, LY303511, NVP.BEZ235, PI.103, PKI.179, ku.0063794, WYE.354, AZD8055, temsirolimus, LY3023414, PP242, palomid.529, PF.04691502",0.288192770958809,0.161780778092374,FALSE +"HCC15","Pearson.est","NFkB pathway inhibitor",0.49384,1.14,0.317,382,0.647,"EVP4593, betulinic.acid, curcumin, bortezomib, Ro.106.9920, parthenolide....",0.498940737782249,0.1890957193313,FALSE +"HCC15","Pearson.est","opioid receptor agonist",-0.55045,-1.53,0.0629,1213,0.304,"ADL5859, spiradoline, cebranopadol, BW.180C",1.20134935455473,0.517126416391246,FALSE +"HCC15","Pearson.est","p38 MAPK inhibitor",0.32999,0.758,0.793,548,0.88,"talmapimod, SB.239063, SB.242235, skepinone.l",0.100726812682396,0.0555173278498314,FALSE +"HCC15","Pearson.est","PARP inhibitor",0.5528,1.28,0.16,380,0.488,"niraparib, talazoparib, olaparib, PJ.34",0.795880017344075,0.311580177997289,FALSE +"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.47233,1.09,0.349,599,0.671,"regorafenib, sorafenib, pazopanib, trapidil, motesanib, axitinib, imatinib, KI.8751, telatinib, nintedanib, ponatinib, vatalanib, dovitinib, sunitinib, masitinib, crenolanib, CP.673451",0.45717457304082,0.173277479831008,FALSE +"HCC15","Pearson.est","phosphatase inhibitor",0.33167,0.765,0.777,295,0.889,"mycophenolic.acid, mycophenolate.mofetil, GSK2830371",0.109578981199086,0.0510982390297863,FALSE +"HCC15","Pearson.est","phosphodiesterase inhibitor",-0.32648,-0.935,0.521,1136,0.705,"enoximone, EMD.53998, GSK256066, anagrelide",0.283162276700476,0.151810883008601,FALSE +"HCC15","Pearson.est","PI3K inhibitor",0.49155,1.14,0.303,484,0.647,"CUDC.907, taselisib, CH5132799, buparlisib, YM.201636, GSK2126458, alpelisib, BGT226, PF.05212384, GDC.0980, PI3K.IN.2, PIK.75, LY303511, NVP.BEZ235, PI.103",0.518557371497695,0.1890957193313,FALSE +"HCC15","Pearson.est","PLK inhibitor",0.8217,1.89,0,235,0.0347,"volasertib, GW.843682X, BI.2536, NMS.1286937, GSK461364, rigosertib",Inf,1.45967052520913,TRUE +"HCC15","Pearson.est","potassium channel blocker",-0.48256,-1.42,0.133,1122,0.387,"dofetilide, ibutilide, mepivacaine, meglitinide",0.876148359032914,0.412289034981089,FALSE +"HCC15","Pearson.est","PPAR receptor agonist",-0.36017,-1,0.402,519,0.662,"oleoylethanolamide, GW.501516, pterostilbene, ciprofibrate, S26948, fenofibrate, clofibrate",0.39577394691553,0.1791420105603,FALSE +"HCC15","Pearson.est","progesterone receptor agonist",-0.42412,-1.19,0.244,1204,0.489,"levonorgestrel, danazol, norethindrone.acetate, norethindrone",0.612610173661271,0.31069114087638,FALSE +"HCC15","Pearson.est","proteasome inhibitor",0.39279,0.902,0.614,626,0.767,"carfilzomib, bortezomib, delanzomib, ONX.0914",0.211831628858832,0.115204636051019,FALSE +"HCC15","Pearson.est","protein synthesis inhibitor",0.46433,1.08,0.359,188,0.672,"anguidine, bruceantin, homoharringtonine, thiostrepton, azomycin..2.nitroimidazole.",0.444905551421681,0.172630726946175,FALSE +"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.58377,1.35,0.107,397,0.405,"NVP.TAE226, tyrphostin.A9, mubritinib, CP.724714",0.97061622231479,0.392544976785331,FALSE +"HCC15","Pearson.est","RAF inhibitor",0.66,1.53,0.0431,298,0.255,"regorafenib, sorafenib, TAK.632, SB.590885, GDC.0879, AZ.628, RAF265",1.36552272983927,0.593459819566045,FALSE +"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.69013,1.59,0.0299,163,0.208,"regorafenib, sorafenib, cabozantinib",1.52432881167557,0.681936665037238,TRUE +"HCC15","Pearson.est","retinoid receptor agonist",0.67601,1.6,0.0272,360,0.276,"fenretinide, adarotene, bexarotene, CD.437, tamibarotene, AM.580",1.5654310959658,0.559090917934782,FALSE +"HCC15","Pearson.est","ribonucleotide reductase inhibitor",0.44563,1.04,0.415,742,0.646,"LY2334737, clofarabine, fludarabine, pentostatin, gemcitabine, fludarabine.phosphate, triapine, cladribine",0.381951903287907,0.189767482004916,FALSE +"HCC15","Pearson.est","serotonin receptor agonist",-0.40391,-1.19,0.227,1208,0.489,"SR.57227A, aripiprazole, NAN.190",0.643974142806877,0.31069114087638,FALSE +"HCC15","Pearson.est","serotonin receptor antagonist",0.39675,0.909,0.604,91,0.771,"sertindole, lurasidone",0.218963061378868,0.112945621949043,FALSE +"HCC15","Pearson.est","sodium channel blocker",0.35678,0.827,0.718,517,0.819,"ajmaline, benzethonium, butamben, triamterene, lappaconite, brivaracetam",0.1438755557577,0.0867160982395816,FALSE +"HCC15","Pearson.est","src inhibitor",-0.50248,-1.41,0.0955,1397,0.349,"saracatinib, dasatinib",1.01999662841625,0.45717457304082,FALSE +"HCC15","Pearson.est","sterol demethylase inhibitor",-0.30715,-0.878,0.567,1338,0.733,"terconazole, lanoconazole",0.246416941107093,0.134896025358872,FALSE +"HCC15","Pearson.est","TGF beta receptor inhibitor",0.31781,0.724,0.825,596,0.87,"LY2109761, adaprev, D.4476",0.0835460514500749,0.0604807473813815,FALSE +"HCC15","Pearson.est","thymidylate synthase inhibitor",0.6286,1.44,0.0626,504,0.32,"raltitrexed, trifluridine, doxifluridine, ftorafur, carmofur",1.20342566678957,0.494850021680094,FALSE +"HCC15","Pearson.est","topoisomerase inhibitor",0.6338,1.48,0.0664,508,0.325,"irinotecan, idarubicin, topotecan, exatecan.mesylate, genz.644282, rubitecan, daunorubicin, doxorubicin, epirubicin, valrubicin, TAS.103, SN.38, amonafide, teniposide, beta.lapachone, amsacrine, camptothecin, etoposide.phosphate, etoposide, nemorubicin, mitoxantrone",1.17783192063198,0.488116639021126,FALSE +"HCC15","Pearson.est","tubulin polymerization inhibitor",0.44039,1.02,0.45,725,0.651,"albendazole, taltobulin, docetaxel, fosbretabulin, parbendazole, vinorelbine, paclitaxel, vindesine, combretastatin.A.4, fenbendazole, indibulin, vincristine, podophyllotoxin, verubulin, BNC105, KX2.391, nocodazole, oxibendazole, flubendazole, vinblastine, dolastatin.10",0.346787486224656,0.186419011431808,FALSE +"HCC15","Pearson.est","tyrosine kinase inhibitor",0.51733,1.19,0.254,262,0.599,"regorafenib, NVP.TAE226, sorafenib, bafetinib, cabozantinib, tyrphostin.A9, hypericin, UNC2250, tivantinib, mubritinib",0.595166283380062,0.222573177610689,FALSE +"HCC15","Pearson.est","VEGFR inhibitor",0.46613,1.06,0.396,574,0.639,"regorafenib, foretinib, sorafenib, golvatinib, pazopanib, cabozantinib, motesanib, axitinib, ENMD.2076, RAF265, KI.8751, AEE788, XL.647, telatinib, OSI.930, nintedanib, PD.173074, vatalanib, dovitinib, lucitanib, sunitinib, tivozanib",0.402304814074488,0.1944991418416,FALSE +"HCC15","Pearson.est","vitamin D receptor agonist",0.55656,1.29,0.164,646,0.49,"maxacalcitol, tacalcitol, alfacalcidol, paricalcitol, calcitriol, ercalcitriol, doxercalciferol",0.785156151952302,0.309803919971486,FALSE +"H460","Pearson.est","EGFR inhibitor",0.16222,0.499,1,234,0.988,"poziotinib, pelitinib, AZD8931, vandetanib, gefitinib, BMS.690514, icotinib, PD.168393, tyrphostin.AG.494, dacomitinib, lapatinib, AEE788, canertinib, salvianolic.acid.B",0,0.00524305541237188,FALSE +"H460","Pearson.est","Abl kinase inhibitor",-0.28599,-0.652,0.897,771,1,"flumatinib, metatinib, ZM.306416, bafetinib, bosutinib, nilotinib, imatinib, tozasertib, KW.2449",0.0472075569559079,0,FALSE +"H460","Pearson.est","acetylcholine receptor agonist",-0.67782,-1.57,0.0321,1049,0.217,"oxiracetam, nefiracetam, xanomeline, pilocarpine",1.49349496759513,0.66354026615147,TRUE +"H460","Pearson.est","acetylcholine receptor antagonist",0.78975,2.41,0,301,0.0114,"hyoscyamine, diphemanil, darifenacin, iododexetimide, dicycloverine",Inf,1.94309514866353,TRUE +"H460","Pearson.est","adenosine receptor antagonist",0.32269,0.925,0.577,983,0.798,"istradefylline, SCH.58261, MRS.1220, CGS.15943, sulmazole, PSB.1115, theophylline",0.238824186844269,0.0979971086492706,FALSE +"H460","Pearson.est","adrenergic receptor agonist",-0.21203,-0.488,0.985,1363,1,"midodrine",0.00656376950238827,0,FALSE +"H460","Pearson.est","adrenergic receptor antagonist",-0.31153,-0.729,0.829,1018,1,"naftidrofuryl, dronedarone, atipamezole, carvedilol, levobunolol, idazoxan, oxprenolol",0.0814454694497265,0,FALSE +"H460","Pearson.est","AKT inhibitor",-0.55866,-1.27,0.166,830,0.611,"AT7867, GDC.0068, palomid.529, MK.2206, CCT128930, AZD5363, ONC201, A.674563, triciribine, uprosertib",0.779891911959945,0.213958789757446,FALSE +"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27634,-0.639,0.908,827,1,"NVP.TAE684, AP26113, AZD3463, alectinib, DMH1",0.0419141514789149,0,FALSE +"H460","Pearson.est","androgen receptor antagonist",0.6276,1.84,0.0214,543,0.165,"nilutamide, bicalutamide, flutamide, enzalutamide, RU.58841, cyproterone.acetate",1.66958622665081,0.782516055786094,TRUE +"H460","Pearson.est","antioxidant",-0.43117,-0.993,0.486,833,0.875,"trolox, benfotiamine, taurine",0.313363730737707,0.0579919469776868,FALSE +"H460","Pearson.est","AP inhibitor",-0.37278,-0.855,0.691,926,1,"embelin, tanshinone.i, LCL.161",0.160521952625802,0,FALSE +"H460","Pearson.est","ATPase inhibitor",-0.29431,-0.677,0.892,1137,1,"digoxin, NMS.873, evodiamine, oligomycin.a",0.0496351456238769,0,FALSE +"H460","Pearson.est","Aurora kinase inhibitor",-0.71116,-1.65,0.0216,1142,0.229,"tozasertib, PHA.680632, barasertib, CYC116, KW.2449, GSK1070916, PF.03814735, danusertib, alisertib, ENMD.2076, AMG900, MK.8745, CCT137690, SNS.314, barasertib.HQPA, AT.9283, hesperadin, ZM.447439",1.66554624884907,0.640164517660112,TRUE +"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.41774,-0.949,0.529,896,0.936,"josamycin, radezolid, azalomycin.b, valnemulin",0.276544327964814,0.0287241512618947,FALSE +"H460","Pearson.est","bacterial DNA gyrase inhibitor",0.30972,0.936,0.514,1002,0.845,"sarafloxacin, sparfloxacin, finafloxacin, novobiocin, trovafloxacin, nadifloxacin, norfloxacin, lomefloxacin",0.289036881004724,0.0731432910503077,FALSE +"H460","Pearson.est","BCL inhibitor",-0.36481,-0.836,0.714,1256,1,"gossypol, TW.37",0.146301788223826,0,FALSE +"H460","Pearson.est","Bcr.Abl kinase inhibitor",0.24909,0.717,0.803,4,0.996,"dasatinib",0.095284454721319,0.00174066157630127,FALSE +"H460","Pearson.est","benzodiazepine receptor agonist",0.21484,0.665,0.931,109,1,"gamma.aminobutyric.acid, eprinomectin, temazepam",0.0310503190186574,0,FALSE +"H460","Pearson.est","bromodomain inhibitor",-0.92649,-2.12,0,1336,0.000904,"bromosporine, I.BET.762, PFI.1, I.BET151, JQ1...., OTX015",Inf,3.04383156952464,TRUE +"H460","Pearson.est","calcium channel blocker",-0.61246,-1.41,0.0777,1085,0.473,"penfluridol, mibefradil, tetrandrine, SR.33805, carboxyamidotriazole",1.10957898119909,0.325138859262188,FALSE +"H460","Pearson.est","CC chemokine receptor antagonist",-0.5472,-1.24,0.185,1010,0.667,"ZK811752, navarixin, PF.04136309, SB.225002",0.732828271596986,0.175874166083451,FALSE +"H460","Pearson.est","CDK inhibitor",-0.69966,-1.63,0.0185,1112,0.154,"P276.00, alvocidib, kenpaullone, aminopurvalanol.a, TG.02, AZD5438, BMS.265246, JNJ.7706621, BMS.387032, PHA.793887, palbociclib, abemaciclib, dinaciclib, ribociclib, AT.7519, indisulam, R547",1.73282827159699,0.812479279163537,TRUE +"H460","Pearson.est","CHK inhibitor",-0.50792,-1.17,0.265,778,0.746,"CHIR.124, LY2603618, LY2606368, AZD7762, PF.477736, SB.218078",0.576754126063192,0.127261172527331,FALSE +"H460","Pearson.est","cyclooxygenase inhibitor",-0.16784,-0.39,0.995,960,0.998,"ramifenazone, phenazone, aspirin, FR.122047, acetylsalicylsalicylic.acid, tryptanthrin",0.00217691925427455,0.000869458712628891,FALSE +"H460","Pearson.est","cytochrome P450 inhibitor",0.5535,1.68,0.0227,120,0.221,"morin, eplerenone, metyrapone",1.64397414280688,0.655607726314889,TRUE +"H460","Pearson.est","DNA alkylating agent",-0.50625,-1.16,0.283,1247,0.743,"estramustine, TH.302, streptozotocin, satraplatin, mitomycin.c",0.54821356447571,0.129011186239425,FALSE +"H460","Pearson.est","DNA inhibitor",-0.35517,-0.821,0.741,946,1,"mechlorethamine, teroxirone, melphalan, valrubicin, pibenzimol, primaquine, oxaliplatin",0.130181792020672,0,FALSE +"H460","Pearson.est","DNA methyltransferase inhibitor",-0.61168,-1.38,0.0894,898,0.477,"disulfiram, SGI.1027, decitabine, azacitidine, fdcyd",1.04866248120408,0.321481620959886,FALSE +"H460","Pearson.est","DNA polymerase inhibitor",-0.48187,-1.12,0.311,1158,0.743,"adefovir.dipivoxil, idoxuridine, cephalomannine, trifluridine",0.507239610973163,0.129011186239425,FALSE +"H460","Pearson.est","DNA synthesis inhibitor",-0.45553,-1.05,0.413,1331,0.829,"anisomycin, cyclocytidine, mitomycin.c",0.384049948343599,0.0814454694497265,FALSE +"H460","Pearson.est","dopamine receptor antagonist",-0.25215,-0.576,0.946,648,1,"thioproperazine, piperacetazine, paliperidone, oxiperomide, raclopride, lurasidone, UH.232...., acetophenazine, sertindole",0.0241088635982073,0,FALSE +"H460","Pearson.est","estrogen receptor agonist",0.41944,1.26,0.176,844,0.456,"ethinyl.estradiol, estradiol.cypionate, levonorgestrel, PPT, estrone, equol, estradiol, erteberel",0.75448733218585,0.341035157335565,FALSE +"H460","Pearson.est","estrogen receptor antagonist",-0.45128,-1.03,0.426,773,0.855,"danazol, raloxifene, toremifene, clomifene",0.370590400897281,0.0680338852718274,FALSE +"H460","Pearson.est","FGFR inhibitor",-0.4501,-1.02,0.443,1248,0.855,"regorafenib, lucitanib",0.35359627377693,0.0680338852718274,FALSE +"H460","Pearson.est","FLT3 inhibitor",-0.49698,-1.14,0.301,1142,0.742,"tozasertib, TG.101348, TG.02, KW.2449, pacritinib, sorafenib, ENMD.2076",0.521433504406157,0.129596094720973,FALSE +"H460","Pearson.est","glucocorticoid receptor agonist",0.28039,0.82,0.684,1049,0.881,"hydrocortisone, triamcinolone.acetonide, piretanide, fluocinolone.acetonide, desonide, prednisolone.acetate, halcinonide, clobetasol.propionate, rimexolone, ciclesonide, flumethasone, betamethasone, beclomethasone.dipropionate, triamcinolone, halobetasol.propionate, dexamethasone.acetate, methylprednisolone, prednisolone.hemisuccinate, difluprednate, fluticasone.propionate, prednisolone, flumethasone.pivalate, fluorometholone, fludroxycortide, deflazacort",0.164943898279884,0.0550240915879521,FALSE +"H460","Pearson.est","glutamate receptor antagonist",0.47851,1.36,0.12,52,0.442,"latrepirdine, SIB.1757, JNJ.16259685, kynurenic.acid, CGP.37849",0.920818753952375,0.354577730650908,FALSE +"H460","Pearson.est","glycogen synthase kinase inhibitor",-0.20858,-0.483,0.983,1119,1,"AZD2858, kenpaullone",0.00744648216786438,0,FALSE +"H460","Pearson.est","growth factor receptor inhibitor",-0.571,-1.32,0.125,870,0.572,"PHA.848125, AZD3463, lestaurtinib, GW.441756, GSK1838705A, danusertib",0.903089986991944,0.242603971206976,FALSE +"H460","Pearson.est","HCV inhibitor",-0.58901,-1.35,0.104,1298,0.521,"mericitabine, narlaprevir",0.98296666070122,0.283162276700476,FALSE +"H460","Pearson.est","HDAC inhibitor",-0.63847,-1.46,0.065,1046,0.376,"RGFP966, RG2833, R306465, belinostat, dacinostat, SB.939, PCI.24781, chidamide, entinostat, NSC.3852, resminostat, M.344, AR.42, givinostat, vorinostat, mocetinostat, scriptaid, trichostatin.a",1.18708664335714,0.424812155072339,FALSE +"H460","Pearson.est","histamine receptor antagonist",-0.26133,-0.6,0.949,991,1,"ebastine, pheniramine, chloropyramine, terfenadine, tiotidine, levocetirizine",0.0227337875727074,0,FALSE +"H460","Pearson.est","HMGCR inhibitor",0.43828,1.31,0.154,816,0.444,"pitavastatin, simvastatin, lovastatin, fluvastatin, atorvastatin, mevastatin",0.812479279163537,0.35261702988538,FALSE +"H460","Pearson.est","HSP inhibitor",-0.45917,-1.06,0.391,1096,0.829,"VER.49009, alvespimycin, XL888, PU.H71, tanespimycin",0.407823242604133,0.0814454694497265,FALSE +"H460","Pearson.est","JAK inhibitor",-0.47959,-1.1,0.349,873,0.772,"filgotinib, CEP.33779, PRT062070, lestaurtinib, baricitinib, tozasertib, TG.101348, TG.02, TG.101209, AZ960, pacritinib, AT.9283",0.45717457304082,0.112382699664264,FALSE +"H460","Pearson.est","KIT inhibitor",-0.43006,-0.991,0.486,1034,0.856,"imatinib, vatalanib, pazopanib, KI.8751, regorafenib, sorafenib, OSI.930",0.313363730737707,0.0675262353228468,FALSE +"H460","Pearson.est","MDM inhibitor",-0.39566,-0.912,0.592,1070,0.998,"RITA, serdemetan",0.22767829327708,0.000869458712628891,FALSE +"H460","Pearson.est","MEK inhibitor",-0.31095,-0.714,0.853,1071,1,"PD.98059, BIX.02188, arctigenin, nobiletin",0.069050968832477,0,FALSE +"H460","Pearson.est","MET inhibitor",0.4836,1.48,0.0735,321,0.356,"PF.04217903, NVP.BVU972, PHA.665752, LY2801653, INC.280",1.1337126609158,0.448550002027125,FALSE +"H460","Pearson.est","microtubule inhibitor",-0.70341,-1.63,0.0181,1280,0.154,"colchicine, vinflunine, podophyllotoxin, cabazitaxel, D.64131",1.74232142513082,0.812479279163537,TRUE +"H460","Pearson.est","mTOR inhibitor",-0.25068,-0.581,0.958,548,1,"LY3023414, ku.0063794, SB.2343, GDC.0980, PI.103, torin.1, WAY.600, voxtalisib, PF.05212384, deforolimus, MLN0128, PKI.179, palomid.529, WYE.354, WYE.125132, GSK2126458, XL388, AZD2014, LY303511, AZD8055, torin.2",0.0186344909214556,0,FALSE +"H460","Pearson.est","NFkB pathway inhibitor",-0.59938,-1.39,0.0986,1251,0.49,"IKK.2.inhibitor.V, bortezomib, parthenolide...., EVP4593, betulinic.acid",1.00612308505879,0.309803919971486,FALSE +"H460","Pearson.est","opioid receptor agonist",0.33388,0.975,0.454,257,0.924,"BW.180C, ADL5859, cebranopadol, spiradoline",0.342944147142896,0.0343280287798933,FALSE +"H460","Pearson.est","p38 MAPK inhibitor",-0.57063,-1.31,0.13,937,0.565,"SB.242235, CMPD.1, VX.702, SB.239063, talmapimod",0.886056647693163,0.247951552180562,FALSE +"H460","Pearson.est","PARP inhibitor",-0.51468,-1.19,0.259,894,0.752,"AZD2461, E7449, PJ.34, olaparib, talazoparib, niraparib",0.586700235918748,0.123782159408358,FALSE +"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.39097,-0.899,0.611,981,1,"SU014813, CP.673451, imatinib, axitinib, vatalanib, pazopanib, crenolanib, KI.8751, trapidil, regorafenib, sorafenib",0.213958789757446,0,FALSE +"H460","Pearson.est","phosphatase inhibitor",-0.26258,-0.614,0.924,958,1,"CID.5458317, GSK2830371, mycophenolate.mofetil, mycophenolic.acid",0.0343280287798933,0,FALSE +"H460","Pearson.est","phosphodiesterase inhibitor",-0.26779,-0.611,0.926,1308,1,"trequinsin",0.0333890133180656,0,FALSE +"H460","Pearson.est","PI3K inhibitor",-0.19127,-0.444,0.991,847,1,"AZD6482, BGT226, TG.100713, taselisib, buparlisib, GSK2126458, YM.201636, CUDC.907, LY303511, PIK.75",0.00392634551472468,0,FALSE +"H460","Pearson.est","PLK inhibitor",-0.84733,-1.96,0,1221,0.00994,"rigosertib, HMN.214, volasertib, GSK461364, NMS.1286937, GW.843682X, BI.2536",Inf,2.00261361560269,TRUE +"H460","Pearson.est","potassium channel blocker",-0.30262,-0.696,0.886,1041,1,"ML133, oleoylethanolamide",0.0525662781129492,0,FALSE +"H460","Pearson.est","PPAR receptor agonist",0.22623,0.663,0.865,1122,0.943,"fenofibrate, pterostilbene, GW.501516, S26948, clofibrate, ciprofibrate, oleoylethanolamide",0.0629838925351858,0.0254883072626717,FALSE +"H460","Pearson.est","progesterone receptor agonist",-0.21538,-0.502,0.981,1040,1,"melengestrol.acetate, dienogest",0.0083309926200515,0,FALSE +"H460","Pearson.est","proteasome inhibitor",-0.47395,-1.09,0.347,711,0.772,"MG.132, carfilzomib, oprozomib, ixazomib.citrate, delanzomib, ixazomib, bortezomib",0.459670525209126,0.112382699664264,FALSE +"H460","Pearson.est","protein synthesis inhibitor",-0.51462,-1.17,0.251,1089,0.746,"cycloheximide, tedizolid.phosphate, puromycin, homoharringtonine, thiostrepton, harringtonine, anguidine, bruceantin",0.600326278518962,0.127261172527331,FALSE +"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.48394,-1.12,0.324,1123,0.743,"mubritinib, tyrphostin.A9, NVP.TAE226",0.489454989793388,0.129011186239425,FALSE +"H460","Pearson.est","RAF inhibitor",-0.55589,-1.28,0.163,1237,0.617,"PLX.4720, regorafenib, TAK.632, RAF265, sorafenib",0.787812395596042,0.209714835966758,FALSE +"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.52481,-1.21,0.22,1248,0.721,"regorafenib, sorafenib",0.657577319177794,0.142064735280571,FALSE +"H460","Pearson.est","retinoid receptor agonist",-0.33156,-0.758,0.796,1364,1,"bexarotene",0.0990869322623309,0,FALSE +"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.50641,-1.14,0.288,969,0.742,"pentostatin, fludarabine, fludarabine.phosphate, cladribine, gemcitabine, clofarabine",0.540607512240769,0.129596094720973,FALSE +"H460","Pearson.est","serotonin receptor agonist",-0.38582,-0.891,0.623,1176,0.994,"zolmitriptan, aripiprazole",0.20551195334083,0.00261361560268669,FALSE +"H460","Pearson.est","serotonin receptor antagonist",-0.43438,-1.01,0.473,934,0.856,"lurasidone, SB.216641, SB.228357, RS.16566, aripiprazole, sertindole",0.325138859262188,0.0675262353228468,FALSE +"H460","Pearson.est","sodium channel blocker",-0.3504,-0.81,0.757,887,1,"triamterene, brivaracetam, A.803467, mexiletine, ajmaline, lappaconite, benzethonium",0.120904120499927,0,FALSE +"H460","Pearson.est","src inhibitor",0.37847,1.14,0.234,23,0.623,"dasatinib, saracatinib",0.630784142589857,0.20551195334083,FALSE +"H460","Pearson.est","sterol demethylase inhibitor",0.28988,0.83,0.662,1030,0.93,"lanoconazole, posaconazole, terconazole, sulconazole, ketoconazole, chlormidazole",0.1791420105603,0.0315170514460649,FALSE +"H460","Pearson.est","TGF beta receptor inhibitor",-0.32206,-0.748,0.796,471,1,"adaprev, SB.431542, LY2109761, D.4476, SB.525334",0.0990869322623309,0,FALSE +"H460","Pearson.est","thymidylate synthase inhibitor",-0.71737,-1.66,0.0115,1057,0.279,"capecitabine, doxifluridine, carmofur, trifluridine, raltitrexed",1.93930215964639,0.554395796726402,FALSE +"H460","Pearson.est","topoisomerase inhibitor",-0.61817,-1.46,0.0564,1078,0.376,"daunorubicin, idarubicin, topotecan, valrubicin, beta.lapachone, rubitecan, amsacrine, teniposide, amonafide, camptothecin, genz.644282, etoposide, SN.38, licochalcone.a, voreloxin, TAS.103, exatecan.mesylate",1.24872089601666,0.424812155072339,FALSE +"H460","Pearson.est","tubulin polymerization inhibitor",-0.71289,-1.63,0.0219,1229,0.154,"indibulin, plinabulin, verubulin, paclitaxel, docetaxel, vinorelbine, dolastatin.10, combretastatin.A.4, vincristine, podophyllotoxin, parbendazole, nocodazole, epothilone.b, fosbretabulin, taltobulin, CYT.997, flubendazole, ABT.751, KX2.391, albendazole",1.65955588515988,0.812479279163537,TRUE +"H460","Pearson.est","tyrosine kinase inhibitor",-0.38504,-0.871,0.657,1080,1,"tyrphostin.AG.99, mubritinib, aminopurvalanol.a, tyrphostin.A9, regorafenib, tivantinib, NVP.TAE226, UNC2250, sorafenib",0.182434630440219,0,FALSE +"H460","Pearson.est","VEGFR inhibitor",-0.37053,-0.848,0.699,931,1,"foretinib, cabozantinib, SU014813, axitinib, vatalanib, pazopanib, golvatinib, KI.8751, regorafenib, RAF265, lucitanib, sorafenib, OSI.930, ENMD.2076",0.155522824254319,0,FALSE +"H460","Pearson.est","vitamin D receptor agonist",0.33657,0.964,0.455,963,0.856,"calcitriol, paricalcitol, maxacalcitol, alfacalcidol, doxercalciferol, tacalcitol, ercalcitriol",0.341988603342888,0.0675262353228468,FALSE +"A549","Pearson.est","EGFR inhibitor",-0.22171,-0.531,0.972,1045,1,"dovitinib, WZ.4002, tyrphostin.AG.1478, CGP.52411, PD.153035, BIBX.1382, WZ8040, CUDC.101, GW.583340, BMS.690514",0.0123337350737254,0,FALSE +"A549","Pearson.est","Abl kinase inhibitor",-0.54434,-1.31,0.145,1284,0.615,"bafetinib, tozasertib, bosutinib",0.838631997765025,0.211124884224583,FALSE +"A549","Pearson.est","acetylcholine receptor agonist",-0.60374,-1.46,0.0856,1253,0.689,"nefiracetam, tremorine, pilocarpine",1.06752623532285,0.161780778092374,FALSE +"A549","Pearson.est","acetylcholine receptor antagonist",-0.65232,-1.59,0.0182,1121,0.923,"darifenacin, methscopolamine, dicycloverine",1.73992861201493,0.0347982989740879,FALSE +"A549","Pearson.est","adenosine receptor antagonist",-0.58887,-1.41,0.111,1088,0.676,"MRS.1220, SCH.58261, PSB.1115, CGS.15943",0.954677021213343,0.170053304058364,FALSE +"A549","Pearson.est","adrenergic receptor agonist",-0.45309,-1.08,0.376,1334,0.767,"isoetharine, lidamidine, clenbuterol, oxymetazoline, buphenine",0.424812155072339,0.115204636051019,FALSE +"A549","Pearson.est","adrenergic receptor antagonist",-0.36477,-0.883,0.61,776,0.85,"pindolol, prazosin, RS.17053, vincamine, atenolol...., carvedilol, idazoxan, dronedarone, naftidrofuryl, levobunolol, atipamezole, practolol",0.214670164989233,0.0705810742857073,FALSE +"A549","Pearson.est","AKT inhibitor",-0.56846,-1.37,0.122,1132,0.655,"AZD5363, A.674563, GSK2110183, CCT128930, GDC.0068, uprosertib, triciribine",0.913640169325252,0.183758700008217,FALSE +"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.15379,0.433,1,1227,0.996,"AP26113, GW.788388, brigatinib, SB.505124, DMH1, alectinib, CEP.37440, NVP.TAE684, AZD3463, lorlatinib, crizotinib",0,0.00174066157630127,FALSE +"A549","Pearson.est","androgen receptor antagonist",-0.61886,-1.51,0.0703,1124,1,"cyproterone.acetate, flutamide, enzalutamide",1.15304467498018,0,FALSE +"A549","Pearson.est","antioxidant",0.21914,0.593,0.935,1132,1,"rutin, mesna, trolox, taurine, chlorogenic.acid, benfotiamine",0.0291883891274822,0,FALSE +"A549","Pearson.est","AP inhibitor",0.68493,1.97,0.0114,166,0.16,"idronoxil, embelin, LCL.161, GDC.0152",1.94309514866353,0.795880017344075,TRUE +"A549","Pearson.est","ATPase inhibitor",0.30904,0.871,0.598,90,0.899,"k.strophanthidin, digitoxin, ouabain",0.223298816011589,0.0462403082667712,FALSE +"A549","Pearson.est","Aurora kinase inhibitor",-0.54511,-1.32,0.162,878,0.634,"danusertib, CYC116, ZM.447439, SNS.314, AMG900, GSK1070916, PF.03814735, AT.9283, PHA.680632, aurora.a.inhibitor.i, barasertib, alisertib, barasertib.HQPA, MLN.8054, tozasertib, MK.8745, CCT129202, CCT137690, hesperadin",0.790484985457369,0.197910742118267,FALSE +"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.29103,-0.717,0.83,1191,0.96,"valnemulin, radezolid",0.0809219076239261,0.0177287669604316,FALSE +"A549","Pearson.est","bacterial DNA gyrase inhibitor",0.34219,0.953,0.485,228,0.927,"lomefloxacin, trovafloxacin",0.314258261397736,0.0329202658555029,FALSE +"A549","Pearson.est","BCL inhibitor",0.33791,0.898,0.522,35,0.891,"obatoclax, venetoclax",0.282329496997738,0.0501222959631252,FALSE +"A549","Pearson.est","Bcr.Abl kinase inhibitor",-0.60892,-1.46,0.0645,1284,0.689,"bafetinib, tozasertib, bosutinib",1.19044028536473,0.161780778092374,FALSE +"A549","Pearson.est","benzodiazepine receptor agonist",-0.52276,-1.27,0.182,1167,0.641,"indiplon, ZK.93423, lorazepam, nefiracetam, temazepam",0.739928612014925,0.193141970481183,FALSE +"A549","Pearson.est","bromodomain inhibitor",-0.43342,-1.05,0.395,683,0.779,"bromosporine, OTX015, I.BET.762, I.BET151, JQ1....",0.40340290437354,0.108462542327436,FALSE +"A549","Pearson.est","calcium channel blocker",-0.50068,-1.2,0.253,949,0.666,"pranidipine, efonidipine.monoethanolate, SR.33805, penfluridol, tetrandrine, cinnarazine",0.596879478824182,0.176525770829699,FALSE +"A549","Pearson.est","CC chemokine receptor antagonist",-0.57928,-1.36,0.119,1258,0.573,"RS.504393, ZK811752, PF.04136309",0.924453038607469,0.24184537803261,FALSE +"A549","Pearson.est","CDK inhibitor",-0.51592,-1.24,0.219,1012,0.638,"aminopurvalanol.a, CR8..R., JNJ.7706621, abemaciclib, ribociclib, BMS.387032, R547, arcyriaflavin.a, dinaciclib, BMS.265246, TG.02, AZD5438",0.659555885159882,0.195179321278838,FALSE +"A549","Pearson.est","CHK inhibitor",-0.57618,-1.39,0.117,951,0.662,"SCH.900776, SB.218078, LY2606368, AZD7762, CHIR.124",0.931814138253838,0.1791420105603,FALSE +"A549","Pearson.est","cyclooxygenase inhibitor",0.22342,0.615,0.903,153,1,"AM.404, acetylsalicylsalicylic.acid, metoxibutropate, amfenac",0.0443122496864942,0,FALSE +"A549","Pearson.est","cytochrome P450 inhibitor",0.36678,1,0.458,84,0.878,"eplerenone, clotrimazole",0.339134521996131,0.0565054840938974,FALSE +"A549","Pearson.est","DNA alkylating agent",-0.33751,-0.819,0.692,715,0.896,"ifosfamide, cyclophosphamide, temozolomide, carboplatin, dianhydrogalactitol, mitomycin.c, carmustine, cisplatin, satraplatin, TH.302",0.159893905543242,0.0476919903378748,FALSE +"A549","Pearson.est","DNA inhibitor",0.23375,0.643,0.878,127,1,"sangivamycin, bendamustine, melphalan",0.0565054840938974,0,FALSE +"A549","Pearson.est","DNA methyltransferase inhibitor",-0.34927,-0.84,0.665,1371,0.883,"decitabine",0.177178354696895,0.0540392964224314,FALSE +"A549","Pearson.est","DNA polymerase inhibitor",-0.2871,-0.694,0.848,1419,0.928,"foscarnet",0.0716041477432862,0.0324520237811379,FALSE +"A549","Pearson.est","DNA synthesis inhibitor",-0.38306,-0.905,0.602,996,0.854,"mitomycin.c, enocitabine, CB.10.277, cisplatin, cyclocytidine, anisomycin, artesunate",0.220403508742175,0.068542129310995,FALSE +"A549","Pearson.est","dopamine receptor antagonist",-0.32359,-0.77,0.73,1082,0.95,"acetophenazine, isofloxythepin, sertindole, mesoridazine, nemonapride, piperacetazine",0.136677139879544,0.0222763947111523,FALSE +"A549","Pearson.est","estrogen receptor agonist",0.38054,1.02,0.425,332,0.965,"levonorgestrel, equol, PPT, erteberel, estradiol.cypionate",0.371611069949688,0.0154726866562074,FALSE +"A549","Pearson.est","estrogen receptor antagonist",0.42006,1.15,0.273,281,0.883,"danazol, toremifene, tamoxifen, raloxifene",0.563837352959244,0.0540392964224314,FALSE +"A549","Pearson.est","FGFR inhibitor",0.38258,1.03,0.375,273,1,"erdafitinib, lucitanib, orantinib, lenvatinib, AZD4547",0.425968732272281,0,FALSE +"A549","Pearson.est","FLT3 inhibitor",-0.56413,-1.36,0.124,1175,0.573,"gilteritinib, quizartinib, midostaurin, sorafenib, pacritinib, TG.02, tozasertib, TG.101348",0.906578314837765,0.24184537803261,FALSE +"A549","Pearson.est","glucocorticoid receptor agonist",0.24596,0.669,0.873,1098,1,"hydrocortisone, betamethasone, piretanide, triamcinolone, triamcinolone.acetonide, prednisolone.hemisuccinate, halcinonide, fluocinolone.acetonide, deflazacort, flumethasone, flumethasone.pivalate, ciclesonide, desonide, fluorometholone, prednisolone, dexamethasone.acetate, rimexolone, fluticasone.propionate, difluprednate, fludroxycortide, halobetasol.propionate, prednisolone.acetate, methylprednisolone, beclomethasone.dipropionate, clobetasol.propionate",0.0589857562944303,0,FALSE +"A549","Pearson.est","glutamate receptor antagonist",0.21245,0.573,0.935,349,1,"felbamate, tiletamine, LY456236, MTPG, diazooxonorleucine, CPP, kynurenic.acid",0.0291883891274822,0,FALSE +"A549","Pearson.est","glycogen synthase kinase inhibitor",0.18226,0.491,0.989,101,1,"tideglusib",0.0048037084028206,0,FALSE +"A549","Pearson.est","growth factor receptor inhibitor",0.39486,1.08,0.344,879,0.981,"GW.441756, GSK1838705A, lestaurtinib, GSK1904529A, AZD3463, PHA.848125, danusertib",0.46344155742847,0.0083309926200515,FALSE +"A549","Pearson.est","HCV inhibitor",0.44735,1.23,0.206,66,0.888,"narlaprevir, embelin",0.686132779630847,0.051587034221399,FALSE +"A549","Pearson.est","HDAC inhibitor",-0.62214,-1.48,0.069,1087,0.915,"chidamide, entinostat, trichostatin.a, mocetinostat, dacinostat, belinostat, romidepsin, vorinostat, R306465, SB.939, RGFP966, M.344, panobinostat, resminostat, AR.42, givinostat, scriptaid",1.16115090926274,0.0385789059335517,FALSE +"A549","Pearson.est","histamine receptor antagonist",0.28724,0.78,0.681,82,1,"zolantidine, ebastine, astemizole",0.166852888087215,0,FALSE +"A549","Pearson.est","HMGCR inhibitor",0.56258,1.53,0.0889,180,0.454,"pitavastatin, atorvastatin, mevastatin, fluvastatin",1.05109823902979,0.342944147142896,FALSE +"A549","Pearson.est","HSP inhibitor",-0.47254,-1.13,0.329,1039,0.771,"VER.49009, NVP.AUY922, alvespimycin, guanidine, tanespimycin",0.482804102050026,0.112945621949043,FALSE +"A549","Pearson.est","JAK inhibitor",-0.47599,-1.13,0.322,1046,0.771,"AZ960, AT.9283, WHI.P154, TG.101209, pacritinib, TG.02, tozasertib, TG.101348",0.492144128304169,0.112945621949043,FALSE +"A549","Pearson.est","KIT inhibitor",-0.44811,-1.07,0.389,1122,0.761,"telatinib, midostaurin, pazopanib, KI.8751, sorafenib",0.410050398674292,0.118615343229427,FALSE +"A549","Pearson.est","MDM inhibitor",-0.47102,-1.12,0.332,783,0.762,"nutlin.3, CGM097, serdemetan, RITA",0.478861916295964,0.1180450286604,FALSE +"A549","Pearson.est","MEK inhibitor",0.3419,0.934,0.498,268,0.912,"TAK.733, cobimetinib, MEK162, Ro.4987655, selumetinib, PD.318088, AZD8330, U.0126",0.302770657240282,0.0400051616715838,FALSE +"A549","Pearson.est","MET inhibitor",-0.50455,-1.21,0.252,1130,0.675,"LY2801653, INC.280",0.598599459218456,0.170696227168975,FALSE +"A549","Pearson.est","microtubule inhibitor",-0.27771,-0.674,0.876,641,0.932,"vinblastine, triclabendazole, cytochalasin.b, secnidazole, colchicine, vinflunine, D.64131",0.0574958938319193,0.0305840876460186,FALSE +"A549","Pearson.est","mTOR inhibitor",-0.52775,-1.26,0.197,1128,0.627,"NVP.BEZ235, AZD8055, torin.2, LY3023414, SB.2343, PP242, temsirolimus, PKI.179, MLN0128, WYE.354, WYE.125132, everolimus",0.705533773838407,0.202732459169284,FALSE +"A549","Pearson.est","NFkB pathway inhibitor",-0.35647,-0.852,0.663,1343,0.883,"EVP4593, betulinic.acid",0.178486471595227,0.0540392964224314,FALSE +"A549","Pearson.est","opioid receptor agonist",0.58519,1.66,0.0602,141,0.346,"ADL5859, BW.180C, cebranopadol",1.22040350874218,0.460923901207223,FALSE +"A549","Pearson.est","p38 MAPK inhibitor",-0.31134,-0.741,0.801,1112,0.97,"TAK.715, SB.242235",0.0963674839157623,0.0132282657337552,FALSE +"A549","Pearson.est","PARP inhibitor",-0.46143,-1.1,0.343,974,0.749,"AG.14361, niraparib, PJ.34, endo.IWR.1",0.464705879957229,0.125518182300534,FALSE +"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.40195,-0.964,0.495,1045,0.835,"dovitinib, axitinib, telatinib, pazopanib, KI.8751, sorafenib, CP.673451, crenolanib",0.305394801066431,0.0783135245163979,FALSE +"A549","Pearson.est","phosphatase inhibitor",-0.30319,-0.731,0.793,1254,0.962,"AS.1949490, mycophenolate.mofetil",0.100726812682396,0.0168249279621871,FALSE +"A549","Pearson.est","phosphodiesterase inhibitor",-0.28597,-0.67,0.882,1300,0.919,"zardaverine, avanafil",0.0545314148681803,0.0366844886138887,FALSE +"A549","Pearson.est","PI3K inhibitor",-0.37422,-0.896,0.59,939,0.848,"AZD6482, GDC.0980, CH5132799, BGT226, TG.100713, YM.201636, buparlisib, NVP.BEZ235, GDC.0941, CUDC.907, LY3023414, PI3K.IN.2, SB.2343, PKI.179",0.229147988357856,0.0716041477432862,FALSE +"A549","Pearson.est","PLK inhibitor",-0.39191,-0.93,0.556,1032,0.853,"volasertib, GW.843682X",0.254925208417942,0.069050968832477,FALSE +"A549","Pearson.est","potassium channel blocker",0.21082,0.571,0.955,1144,1,"mepivacaine, meglitinide, dofetilide, oleoylethanolamide, ibutilide, ML133",0.0199966284162537,0,FALSE +"A549","Pearson.est","PPAR receptor agonist",0.34629,0.927,0.527,949,0.874,"clofibrate, fenofibrate, S26948, oleoylethanolamide, pterostilbene, GW.501516, ciprofibrate",0.278189384787453,0.058488567365597,FALSE +"A549","Pearson.est","progesterone receptor agonist",0.38427,1.01,0.394,45,0.917,"danazol, levonorgestrel",0.404503778174426,0.0376306643299789,FALSE +"A549","Pearson.est","proteasome inhibitor",0.67506,1.81,0.0369,213,0.243,"oprozomib, ONX.0914, ixazomib.citrate, ixazomib",1.43297363384094,0.614393726401688,TRUE +"A549","Pearson.est","protein synthesis inhibitor",-0.40454,-0.966,0.496,1205,0.857,"thiostrepton, mercaptopurine, emetine, chloramphenicol.palmitate, azomycin..2.nitroimidazole., florfenicol",0.304518323509803,0.0670191780768018,FALSE +"A549","Pearson.est","protein tyrosine kinase inhibitor",-0.40576,-0.995,0.459,1115,0.845,"mubritinib, tyrphostin.A9, NVP.TAE226",0.338187314462739,0.0731432910503077,FALSE +"A549","Pearson.est","RAF inhibitor",0.27038,0.744,0.775,116,1,"vemurafenib, AZ.628",0.11069829749369,0,FALSE +"A549","Pearson.est","RET tyrosine kinase inhibitor",-0.45371,-1.11,0.336,829,0.755,"regorafenib, vandetanib, apatinib, sorafenib",0.473660722610156,0.122053048370812,FALSE +"A549","Pearson.est","retinoid receptor agonist",0.48975,1.32,0.149,136,0.783,"adarotene, tamibarotene, LE.135",0.826813731587726,0.106238237942057,FALSE +"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.15465,-0.376,1,1096,1,"LY2334737, cytarabine",0,0,FALSE +"A549","Pearson.est","serotonin receptor agonist",0.83488,2.33,0,13,0.022,"aripiprazole, NAN.190",Inf,1.65757731917779,TRUE +"A549","Pearson.est","serotonin receptor antagonist",0.45206,1.2,0.253,1,0.85,"aripiprazole",0.596879478824182,0.0705810742857073,FALSE +"A549","Pearson.est","sodium channel blocker",-0.53419,-1.27,0.192,1263,0.641,"A.803467, benzocaine, butamben, ajmaline",0.71669877129645,0.193141970481183,FALSE +"A549","Pearson.est","src inhibitor",-0.40016,-0.972,0.493,1374,0.871,"bosutinib",0.30715308072277,0.0599818449923368,FALSE +"A549","Pearson.est","sterol demethylase inhibitor",-0.58229,-1.43,0.097,990,0.695,"sulconazole, posaconazole, chlormidazole, terconazole",1.01322826573376,0.158015195409886,FALSE +"A549","Pearson.est","TGF beta receptor inhibitor",-0.42433,-1.03,0.426,786,0.796,"SB.431542, SB.525334, adaprev",0.370590400897281,0.0990869322623309,FALSE +"A549","Pearson.est","thymidylate synthase inhibitor",-0.28678,-0.701,0.825,905,0.939,"ftorafur, doxifluridine, trifluridine",0.0835460514500749,0.0273344077338891,FALSE +"A549","Pearson.est","topoisomerase inhibitor",-0.38482,-0.932,0.552,828,0.874,"voreloxin, SN.38, daunorubicin, doxorubicin, valrubicin, fleroxacin, amonafide, etoposide, camptothecin, amsacrine, irinotecan, rubitecan, teniposide, exatecan.mesylate, genz.644282, TAS.103, idarubicin",0.258060922270801,0.058488567365597,FALSE +"A549","Pearson.est","tubulin polymerization inhibitor",-0.15251,-0.369,0.999,1338,0.999,"flubendazole, albendazole",0.000434511774017692,0.000434511774017692,FALSE +"A549","Pearson.est","tyrosine kinase inhibitor",-0.38672,-0.927,0.533,1012,0.836,"aminopurvalanol.a, apatinib, mubritinib, tyrphostin.A9, UNC2250, bafetinib, sorafenib, NVP.TAE226, tyrphostin.AG.99, hypericin",0.273272790973428,0.0777937225609836,FALSE +"A549","Pearson.est","VEGFR inhibitor",-0.29677,-0.713,0.822,1221,0.944,"pazopanib, KI.8751, sorafenib, golvatinib, BMS.690514, MGCD.265, foretinib, tivozanib",0.0851281824599496,0.025028005701931,FALSE +"A549","Pearson.est","vitamin D receptor agonist",-0.74254,-1.77,0.00846,1070,0.449,"alfacalcidol, doxercalciferol, maxacalcitol, calcitriol, ercalcitriol, tacalcitol, paricalcitol",2.07262963696098,0.347753658996677,FALSE +"HCC44","Pearson.est","EGFR inhibitor",0.46963,1.29,0.167,272,0.428,"tucatinib, dovitinib, AEE788, poziotinib, AZD8931, dacomitinib, lapatinib, BMS.690514, neratinib, CUDC.101, pelitinib, vandetanib, afatinib, osimertinib, TAK.285, GW.583340, XL.647",0.777283528852417,0.368556230986828,FALSE +"HCC44","Pearson.est","Abl kinase inhibitor",-0.5153,-1.24,0.217,897,0.767,"GZD824, metatinib, dasatinib, flumatinib, KW.2449, ZM.306416, nilotinib, bosutinib",0.66354026615147,0.115204636051019,FALSE +"HCC44","Pearson.est","acetylcholine receptor agonist",-0.63549,-1.56,0.0409,1384,0.353,"tremorine, pilocarpine",1.38827669199266,0.452225294612177,FALSE +"HCC44","Pearson.est","acetylcholine receptor antagonist",-0.2683,-0.668,0.908,1130,0.985,"dicycloverine, methscopolamine",0.0419141514789149,0.00656376950238827,FALSE +"HCC44","Pearson.est","adenosine receptor antagonist",0.40549,1.1,0.315,95,0.517,"CGS.15943, MRS.1220",0.501689446210399,0.286509456906058,FALSE +"HCC44","Pearson.est","adrenergic receptor agonist",-0.41466,-1.01,0.451,874,0.836,"oxymetazoline, norepinephrine, terbutaline, epinephrine, xylazine, clenbuterol, isoetharine, A61603, isoxsuprine, midodrine",0.345823458122039,0.0777937225609836,FALSE +"HCC44","Pearson.est","adrenergic receptor antagonist",0.25514,0.696,0.835,12,0.937,"practolol, atenolol......",0.0783135245163979,0.0282604091122217,FALSE +"HCC44","Pearson.est","AKT inhibitor",0.49673,1.38,0.126,84,0.393,"GDC.0068, uprosertib, GSK2110183, MK.2206",0.899629454882437,0.405607449624573,FALSE +"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.3415,-0.825,0.668,1420,0.977,"AP26113",0.175223537524454,0.0101054362812269,FALSE +"HCC44","Pearson.est","androgen receptor antagonist",-0.63654,-1.58,0.0319,1043,0.361,"enzalutamide, cyproterone.acetate, bicalutamide, flutamide",1.49620931694282,0.442492798094342,FALSE +"HCC44","Pearson.est","antioxidant",-0.6745,-1.64,0.0421,1028,0.298,"rutin, mesna, trolox, benfotiamine, taurine",1.37571790416433,0.525783735923745,FALSE +"HCC44","Pearson.est","AP inhibitor",-0.7244,-1.81,0.0135,1247,0.189,"idronoxil, GDC.0152, LCL.161",1.86966623150499,0.723538195826756,TRUE +"HCC44","Pearson.est","ATPase inhibitor",-0.45006,-1.1,0.355,1253,0.714,"blebbistatin...., digitoxigenin, digitoxin",0.449771646944906,0.146301788223826,FALSE +"HCC44","Pearson.est","Aurora kinase inhibitor",-0.26338,-0.638,0.89,683,0.996,"CCT129202, MK.5108, AMG900, ENMD.2076, alisertib, danusertib, SNS.314, AT.9283, GSK1070916, CCT137690, barasertib.HQPA, ZM.447439, PF.03814735, hesperadin, KW.2449, MK.8745, CYC116",0.0506099933550872,0.00174066157630127,FALSE +"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.21319,0.59,0.924,1141,1,"azithromycin, azalomycin.b, valnemulin, dirithromycin, tilmicosin, tedizolid, radezolid, josamycin",0.0343280287798933,0,FALSE +"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.28852,-0.708,0.827,1018,0.978,"finafloxacin, norfloxacin, lomefloxacin",0.0824944904474534,0.00966114521239857,FALSE +"HCC44","Pearson.est","BCL inhibitor",0.74335,2.02,0.0143,336,0.0575,"HA14.1, TW.37, gossypol, navitoclax, obatoclax, oridonin, ABT.737",1.84466396253494,1.24033215531037,TRUE +"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.48265,-1.17,0.268,897,0.69,"GZD824, metatinib, dasatinib, flumatinib, nilotinib, bosutinib",0.571865205971211,0.161150909262745,FALSE +"HCC44","Pearson.est","benzodiazepine receptor agonist",-0.36798,-0.905,0.578,997,0.903,"nefiracetam, temazepam, indiplon, lorazepam, CGS.20625",0.238072161579471,0.0443122496864942,FALSE +"HCC44","Pearson.est","bromodomain inhibitor",0.78849,2.12,0.00412,311,0.038,"I.BET151, I.BET.762, OTX015, JQ1...., PFI.1, bromosporine",2.38510278396687,1.42021640338319,TRUE +"HCC44","Pearson.est","calcium channel blocker",0.40334,1.11,0.296,435,0.575,"SR.33805, pranidipine, mibefradil, carboxyamidotriazole, fendiline, penfluridol, SKF.96365",0.528708288941061,0.24033215531037,FALSE +"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.40335,-0.978,0.493,1158,0.879,"RS.504393, MK.0812, navarixin",0.30715308072277,0.0560111249262281,FALSE +"HCC44","Pearson.est","CDK inhibitor",-0.26024,-0.637,0.9,1012,0.959,"indirubin, PHA.848125, AZD5438, alvocidib, aminopurvalanol.a, CR8..R., PHA.793887, BMS.265246",0.0457574905606751,0.0181813928293364,FALSE +"HCC44","Pearson.est","CHK inhibitor",-0.72986,-1.79,0.00396,1177,0.153,"PF.477736, CHIR.124, SCH.900776, AZD7762, LY2606368",2.40230481407449,0.815308569182401,TRUE +"HCC44","Pearson.est","cyclooxygenase inhibitor",-0.26619,-0.636,0.883,937,0.942,"tryptanthrin, aspirin, FR.122047, metoxibutropate, phenazone, amfenac, sulfasalazine, acetylsalicylsalicylic.acid, FK.3311",0.0540392964224314,0.0259490972071227,FALSE +"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.5345,-1.3,0.166,1008,0.683,"eplerenone, clotrimazole, metyrapone, itraconazole",0.779891911959945,0.165579296318467,FALSE +"HCC44","Pearson.est","DNA alkylating agent",-0.46407,-1.15,0.29,1408,0.68,"carboplatin, streptozotocin",0.537602002101044,0.167491087293764,FALSE +"HCC44","Pearson.est","DNA inhibitor",0.28408,0.798,0.686,231,0.897,"chlorambucil, metronidazole, melphalan, bendamustine, pibenzimol, carmustine",0.163675884293248,0.0472075569559079,FALSE +"HCC44","Pearson.est","DNA methyltransferase inhibitor",0.41154,1.16,0.3,355,0.533,"azacitidine, disulfiram, fdcyd, SGI.1027",0.522878745280338,0.273272790973428,FALSE +"HCC44","Pearson.est","DNA polymerase inhibitor",-0.49019,-1.21,0.244,846,0.688,"trifluridine, famciclovir, idoxuridine, cephalomannine, foscarnet",0.612610173661271,0.162411561764489,FALSE +"HCC44","Pearson.est","DNA synthesis inhibitor",-0.53086,-1.31,0.169,1329,0.705,"capecitabine, cyclocytidine, altretamine",0.772113295386326,0.151810883008601,FALSE +"HCC44","Pearson.est","dopamine receptor antagonist",-0.53777,-1.34,0.159,1195,0.67,"remoxipride, isofloxythepin, UH.232...., thioproperazine, acetophenazine, piperacetazine, raclopride",0.798602875679548,0.173925197299174,FALSE +"HCC44","Pearson.est","estrogen receptor agonist",-0.33373,-0.809,0.711,1435,0.981,"estradiol.cypionate",0.148130399270234,0.0083309926200515,FALSE +"HCC44","Pearson.est","estrogen receptor antagonist",-0.73878,-1.77,0.0108,1193,0.134,"tamoxifen, danazol, raloxifene",1.96657624451305,0.872895201635192,TRUE +"HCC44","Pearson.est","FGFR inhibitor",0.51394,1.42,0.112,145,0.387,"dovitinib, PD.173074, regorafenib, lenvatinib, erdafitinib",0.950781977329818,0.412289034981089,FALSE +"HCC44","Pearson.est","FLT3 inhibitor",0.28783,0.821,0.668,271,0.901,"dovitinib, sunitinib, quizartinib, TG.02, pacritinib, TG.101348, sorafenib",0.175223537524454,0.045275209020937,FALSE +"HCC44","Pearson.est","glucocorticoid receptor agonist",-0.37827,-0.931,0.569,956,0.9,"flumethasone, triamcinolone, prednisolone.acetate, fludroxycortide, fluticasone.propionate, flumethasone.pivalate, fluocinolone.acetonide, dexamethasone.acetate, fluorometholone, hydrocortisone",0.244887733604929,0.0457574905606751,FALSE +"HCC44","Pearson.est","glutamate receptor antagonist",-0.49883,-1.21,0.246,1168,0.688,"latrepirdine, LY456236, JNJ.16259685, tiletamine, IEM1754, SIB.1757",0.609064892896621,0.162411561764489,FALSE +"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.5602,-1.37,0.127,915,0.632,"CHIR.98014, indirubin, GSK.3.inhibitor.IX, LY2090314, AZD2858, tideglusib, TWS.119",0.896196279044043,0.199282921717615,FALSE +"HCC44","Pearson.est","growth factor receptor inhibitor",-0.46594,-1.13,0.323,763,0.697,"danusertib, lestaurtinib, GW.441756, PHA.848125, GSK1904529A",0.490797477668897,0.156767221901991,FALSE +"HCC44","Pearson.est","HCV inhibitor",-0.28295,-0.677,0.856,809,0.996,"daclatasvir, mericitabine, narlaprevir",0.0675262353228468,0.00174066157630127,FALSE +"HCC44","Pearson.est","HDAC inhibitor",0.24263,0.698,0.849,69,0.976,"tacedinaline, R306465, RGFP966",0.0710923097560473,0.0105501823333082,FALSE +"HCC44","Pearson.est","histamine receptor antagonist",-0.38027,-0.932,0.567,1179,0.925,"levocetirizine, terfenadine, BF2.649, tiotidine, zolantidine, famotidine",0.246416941107093,0.0338582672609674,FALSE +"HCC44","Pearson.est","HMGCR inhibitor",-0.76687,-1.91,0.00135,1142,0.124,"lovastatin, mevastatin, pitavastatin, fluvastatin",2.86966623150499,0.906578314837765,TRUE +"HCC44","Pearson.est","HSP inhibitor",0.17017,0.488,0.987,164,0.986,"NMS.E973, BIIB021",0.00568284733036327,0.0061230850587888,FALSE +"HCC44","Pearson.est","JAK inhibitor",-0.34657,-0.854,0.641,1208,0.948,"AZD1480, filgotinib, CEP.33779, WHI.P154",0.193141970481183,0.0231916626619338,FALSE +"HCC44","Pearson.est","KIT inhibitor",0.39515,1.1,0.322,182,0.517,"motesanib, pazopanib, regorafenib, sunitinib, lenvatinib, masitinib",0.492144128304169,0.286509456906058,FALSE +"HCC44","Pearson.est","MDM inhibitor",-0.28866,-0.71,0.823,1129,0.996,"CGM097",0.0846001647877302,0.00174066157630127,FALSE +"HCC44","Pearson.est","MEK inhibitor",-0.49727,-1.22,0.227,815,0.782,"nobiletin, PD.98059, AZD8330, cobimetinib, BIX.02188, PD.0325901, Ro.4987655, TAK.733, MEK1.2.inhibitor, MEK162, PD.318088, PD.198306, refametinib, PD.184352",0.643974142806877,0.106793246940152,FALSE +"HCC44","Pearson.est","MET inhibitor",-0.45586,-1.1,0.345,831,0.714,"PHA.665752, NVP.BVU972, LY2801653, PF.04217903",0.462180904926726,0.146301788223826,FALSE +"HCC44","Pearson.est","microtubule inhibitor",-0.60213,-1.46,0.0846,1187,0.55,"podophyllotoxin, secnidazole, D.64131, cabazitaxel, colchicine",1.07262963696098,0.259637310505756,FALSE +"HCC44","Pearson.est","mTOR inhibitor",0.46105,1.29,0.173,154,0.428,"PF.05212384, PI.103, GDC.0980, WYE.125132, temsirolimus, GSK2126458, OSI.027, sirolimus, everolimus",0.761953896871205,0.368556230986828,FALSE +"HCC44","Pearson.est","NFkB pathway inhibitor",-0.24019,-0.59,0.931,1048,0.963,"tyloxapol, bindarit, parthenolide, IKK.2.inhibitor.V",0.0310503190186574,0.0163737128754655,FALSE +"HCC44","Pearson.est","opioid receptor agonist",-0.58288,-1.41,0.107,913,0.639,"spiradoline, cebranopadol, ADL5859, BW.180C, trimebutine",0.97061622231479,0.1944991418416,FALSE +"HCC44","Pearson.est","p38 MAPK inhibitor",-0.32432,-0.78,0.758,922,0.981,"talmapimod, VX.702, CMPD.1, TAK.715",0.120330794367946,0.0083309926200515,FALSE +"HCC44","Pearson.est","PARP inhibitor",0.2021,0.576,0.963,358,0.984,"niraparib, talazoparib, olaparib, PJ.34",0.0163737128754655,0.00700490156865849,FALSE +"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.45186,1.28,0.212,182,0.405,"motesanib, dovitinib, pazopanib, regorafenib, linifanib, sunitinib, lenvatinib, masitinib",0.673664139071249,0.392544976785331,FALSE +"HCC44","Pearson.est","phosphatase inhibitor",-0.37252,-0.908,0.557,1133,0.921,"CID.5458317, AS.1949490, bis.maltolato.oxovanadium.IV., BVT.948",0.254144804826271,0.0357403698031511,FALSE +"HCC44","Pearson.est","phosphodiesterase inhibitor",-0.35827,-0.873,0.629,857,0.938,"EMD.53998, zardaverine, GSK256066, trequinsin, anagrelide, papaverine",0.201349354554731,0.0277971616209356,FALSE +"HCC44","Pearson.est","PI3K inhibitor",0.67351,1.87,0.0274,147,0.0857,"taselisib, alpelisib, CH5132799, PI3K.IN.2, PI.828, PF.05212384, PI.103, GDC.0980, GSK2126458, TG100.115, CUDC.907, GDC.0941, buparlisib",1.56224943717961,1.0670191780768,TRUE +"HCC44","Pearson.est","PLK inhibitor",-0.46826,-1.16,0.271,986,0.684,"rigosertib, BI.2536, HMN.214, GSK461364",0.567030709125594,0.164943898279884,FALSE +"HCC44","Pearson.est","potassium channel blocker",-0.44201,-1.07,0.393,1358,0.754,"meglitinide",0.405607449624573,0.122628654130226,FALSE +"HCC44","Pearson.est","PPAR receptor agonist",0.34212,0.964,0.482,955,0.711,"pterostilbene, fenofibrate, S26948, ciprofibrate, oleoylethanolamide, clofibrate, GW.501516",0.31695296176115,0.148130399270234,FALSE +"HCC44","Pearson.est","progesterone receptor agonist",-0.50012,-1.21,0.233,1059,0.688,"norethindrone.acetate, nomegestrol.acetate, norethindrone, danazol, dienogest",0.632644078973981,0.162411561764489,FALSE +"HCC44","Pearson.est","proteasome inhibitor",0.30069,0.859,0.653,205,0.875,"ONX.0914, carfilzomib, oprozomib",0.185086818724926,0.0579919469776868,FALSE +"HCC44","Pearson.est","protein synthesis inhibitor",-0.22448,-0.541,0.964,1344,0.976,"cycloheximide, mercaptopurine",0.0159229660971692,0.0105501823333082,FALSE +"HCC44","Pearson.est","protein tyrosine kinase inhibitor",-0.38774,-0.957,0.506,1307,0.897,"PP.121",0.295849483160201,0.0472075569559079,FALSE +"HCC44","Pearson.est","RAF inhibitor",-0.41693,-1.02,0.441,1170,0.841,"PLX.4720, LGX818, CEP.32496, vemurafenib",0.355561410532161,0.0752040042020878,FALSE +"HCC44","Pearson.est","RET tyrosine kinase inhibitor",0.8022,2.26,0.00356,271,0.0188,"regorafenib, sunitinib, cabozantinib, vandetanib, sorafenib",2.44855000202712,1.72584215073632,TRUE +"HCC44","Pearson.est","retinoid receptor agonist",0.79764,2.26,0,28,0.0188,"adarotene, fenretinide, tamibarotene",Inf,1.72584215073632,TRUE +"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.29565,-0.735,0.78,801,0.984,"triapine, fludarabine, gemcitabine, clofarabine, fludarabine.phosphate, cladribine",0.10790539730952,0.00700490156865849,FALSE +"HCC44","Pearson.est","serotonin receptor agonist",-0.52213,-1.29,0.181,852,0.663,"SR.57227A, pardoprunox, aripiprazole, zolmitriptan",0.742321425130815,0.178486471595227,FALSE +"HCC44","Pearson.est","serotonin receptor antagonist",-0.32414,-0.791,0.744,1145,0.987,"pirenperone, aripiprazole, SB.216641, RS.16566",0.128427064454121,0.00568284733036327,FALSE +"HCC44","Pearson.est","sodium channel blocker",-0.26374,-0.637,0.883,916,0.959,"cibenzoline, benzocaine, lappaconite, oxcarbazepine, A.803467, mexiletine",0.0540392964224314,0.0181813928293364,FALSE +"HCC44","Pearson.est","src inhibitor",-0.47032,-1.18,0.267,832,0.696,"PP.2, TG.100572, PP.1, dasatinib, KX2.391, ZM.306416, bosutinib",0.573488738635425,0.157390760389438,FALSE +"HCC44","Pearson.est","sterol demethylase inhibitor",-0.49216,-1.2,0.241,1074,0.68,"lanoconazole, terconazole",0.617982957425132,0.167491087293764,FALSE +"HCC44","Pearson.est","TGF beta receptor inhibitor",0.24757,0.705,0.781,1091,1,"LY2109761, adaprev, SB.431542, D.4476, repsox, SB.525334",0.1073489661227,0,FALSE +"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.31439,-0.775,0.723,1329,0.967,"capecitabine",0.140861702705469,0.0145735259169983,FALSE +"HCC44","Pearson.est","topoisomerase inhibitor",-0.31153,-0.763,0.776,1257,0.964,"camptothecin, SN.38, etoposide, TAS.103, voreloxin, licochalcone.a",0.110138278741812,0.0159229660971692,FALSE +"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.55697,-1.37,0.127,829,0.632,"combretastatin.A.4, vincristine, oxibendazole, indibulin, vinorelbine, verubulin, BNC105, vinblastine, fenbendazole, albendazole, docetaxel, fosbretabulin, paclitaxel, KX2.391, podophyllotoxin, plinabulin, dolastatin.10, nocodazole, epothilone.d, epothilone.b, ABT.751, CYT.997, flubendazole",0.896196279044043,0.199282921717615,FALSE +"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.20618,-0.5,0.982,1044,0.978,"aminopurvalanol.a, dasatinib, GTP.14564, tyrphostin.AG.99, PP.121, AMG.208",0.00788851221305034,0.00966114521239857,FALSE +"HCC44","Pearson.est","VEGFR inhibitor",0.49863,1.42,0.121,127,0.387,"foretinib, motesanib, dovitinib, AEE788, golvatinib, PD.173074, pazopanib, regorafenib, linifanib, BMS.690514, sunitinib, cabozantinib, lenvatinib",0.91721462968355,0.412289034981089,FALSE +"HCC44","Pearson.est","vitamin D receptor agonist",0.66585,1.87,0.015,290,0.0857,"maxacalcitol, calcitriol, tacalcitol, paricalcitol",1.82390874094432,1.0670191780768,TRUE +"H1703","Pearson.est","EGFR inhibitor",-0.19448,-0.504,0.976,1056,0.998,"lapatinib, BMS.599626, erlotinib, GW.583340, icotinib, rociletinib, TAK.285, BIBX.1382, ARRY.334543, WZ8040, PD.153035, CNX.2006",0.0105501823333082,0.000869458712628891,FALSE +"H1703","Pearson.est","Abl kinase inhibitor",-0.53393,-1.36,0.143,1079,0.653,"bosutinib, GZD824, ponatinib, imatinib, tozasertib, KW.2449, metatinib, ZM.306416",0.844663962534938,0.185086818724926,FALSE +"H1703","Pearson.est","acetylcholine receptor agonist",-0.49601,-1.25,0.209,890,0.622,"xanomeline, nefiracetam, tremorine, pilocarpine",0.679853713888946,0.206209615309181,FALSE +"H1703","Pearson.est","acetylcholine receptor antagonist",0.63669,1.69,0.0353,473,0.324,"diphemanil, hyoscyamine, methscopolamine, darifenacin, iododexetimide",1.45222529461218,0.489454989793388,FALSE +"H1703","Pearson.est","adenosine receptor antagonist",-0.35666,-0.916,0.549,1075,0.718,"theophylline, CGS.15943, istradefylline",0.260427655549908,0.1438755557577,FALSE +"H1703","Pearson.est","adrenergic receptor agonist",0.24471,0.642,0.884,277,0.881,"xylazine, isoetharine, ritodrine, A61603, oxymetazoline",0.0535477349869269,0.0550240915879521,FALSE +"H1703","Pearson.est","adrenergic receptor antagonist",0.45552,1.2,0.248,395,0.523,"atenolol...., propranolol, metoprolol, imiloxan, prazosin, RS.17053, atenolol......, practolol, dihydroergocristine, dronedarone",0.605548319173784,0.281498311132726,FALSE +"H1703","Pearson.est","AKT inhibitor",-0.45353,-1.17,0.285,1021,0.612,"MK.2206, CCT128930, uprosertib, AT7867, A.674563, ONC201, triciribine",0.54515513999149,0.213248577854439,FALSE +"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.50996,-1.3,0.182,999,0.639,"alectinib, AP26113, DMH1, crizotinib, CEP.37440, AZD3463",0.739928612014925,0.1944991418416,FALSE +"H1703","Pearson.est","androgen receptor antagonist",0.69906,1.8,0.0105,122,0.227,"nilutamide, flutamide, enzalutamide",1.97881070093006,0.643974142806877,TRUE +"H1703","Pearson.est","antioxidant",-0.59911,-1.52,0.0772,1147,0.938,"benfotiamine, rutin, chlorogenic.acid",1.11238269966426,0.0277971616209356,FALSE +"H1703","Pearson.est","AP inhibitor",-0.53333,-1.38,0.147,1269,0.739,"idronoxil, LCL.161",0.832682665251824,0.131355561605174,FALSE +"H1703","Pearson.est","ATPase inhibitor",-0.317,-0.804,0.695,967,0.783,"omeprazole, thonzonium, digitoxigenin, rabeprazole, digitoxin, digoxin",0.158015195409886,0.106238237942057,FALSE +"H1703","Pearson.est","Aurora kinase inhibitor",-0.53204,-1.34,0.167,1084,0.596,"TAK.901, AMG900, CCT129202, CYC116, CCT137690, AT.9283, tozasertib, MK.5108, KW.2449, ZM.447439, GSK1070916, hesperadin",0.777283528852417,0.224753740259764,FALSE +"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.31223,0.826,0.653,453,0.768,"tilmicosin, josamycin, azithromycin, dirithromycin",0.185086818724926,0.114638779968488,FALSE +"H1703","Pearson.est","bacterial DNA gyrase inhibitor",0.72485,1.88,0.00223,343,0.402,"sparfloxacin, nadifloxacin, sarafloxacin, lomefloxacin, novobiocin, finafloxacin",2.65169513695184,0.39577394691553,FALSE +"H1703","Pearson.est","BCL inhibitor",0.35381,0.942,0.53,156,0.712,"HA14.1, oridonin",0.275724130399211,0.147520006363144,FALSE +"H1703","Pearson.est","Bcr.Abl kinase inhibitor",-0.44875,-1.13,0.303,1079,0.583,"bosutinib, GZD824, ponatinib, imatinib, tozasertib, metatinib",0.518557371497695,0.234331445240986,FALSE +"H1703","Pearson.est","benzodiazepine receptor agonist",0.40642,1.07,0.334,279,0.641,"gamma.aminobutyric.acid, CL.218872, bentazepam, temazepam",0.476253533188435,0.193141970481183,FALSE +"H1703","Pearson.est","bromodomain inhibitor",0.63731,1.66,0.0436,487,0.302,"I.BET151, I.BET.762, OTX015, bromosporine, JQ1....",1.36051351073141,0.519993057042849,FALSE +"H1703","Pearson.est","calcium channel blocker",-0.55739,-1.41,0.108,1102,0.849,"tetrandrine, mibefradil, penfluridol, carboxyamidotriazole, SR.33805",0.96657624451305,0.0710923097560473,FALSE +"H1703","Pearson.est","CC chemokine receptor antagonist",-0.40228,-1.04,0.413,1396,0.629,"MK.0812, navarixin",0.384049948343599,0.201349354554731,FALSE +"H1703","Pearson.est","CDK inhibitor",-0.53452,-1.35,0.151,1219,0.623,"palbociclib, abemaciclib, indirubin, alvocidib, PHA.848125, NU6027, PHA.793887, dinaciclib, AT.7519",0.821023052706831,0.20551195334083,FALSE +"H1703","Pearson.est","CHK inhibitor",-0.68967,-1.78,0.0277,1329,0.868,"LY2606368, LY2603618, SCH.900776",1.55752023093555,0.0614802748235081,FALSE +"H1703","Pearson.est","cyclooxygenase inhibitor",0.38283,1.01,0.411,209,0.682,"naproxen, piroxicam, metoxibutropate, FR.122047, tepoxalin, suxibuzone",0.386158178123931,0.166215625343521,FALSE +"H1703","Pearson.est","cytochrome P450 inhibitor",0.62909,1.64,0.0585,177,0.275,"morin, PF.4981517",1.23284413391782,0.560667306169737,FALSE +"H1703","Pearson.est","DNA alkylating agent",-0.47959,-1.23,0.23,988,0.562,"ifosfamide, cisplatin, satraplatin, dianhydrogalactitol, streptozotocin, cyclophosphamide, estramustine, carboplatin, mitomycin.c",0.638272163982407,0.250263684430939,FALSE +"H1703","Pearson.est","DNA inhibitor",0.43866,1.15,0.283,320,0.571,"tirapazamine, metronidazole, nimorazole, chlorambucil, bendamustine, nithiamide, busulfan, mechlorethamine, melphalan",0.54821356447571,0.243363891754152,FALSE +"H1703","Pearson.est","DNA methyltransferase inhibitor",-0.53963,-1.39,0.125,985,0.801,"disulfiram, fdcyd, RG108, decitabine",0.903089986991944,0.0963674839157623,FALSE +"H1703","Pearson.est","DNA polymerase inhibitor",0.34251,0.879,0.588,8,0.736,"famciclovir",0.230622673923862,0.133122185662501,FALSE +"H1703","Pearson.est","DNA synthesis inhibitor",-0.3542,-0.898,0.58,1306,0.69,"azodicarbonamide, cyclocytidine, mitomycin.c",0.236572006437063,0.161150909262745,FALSE +"H1703","Pearson.est","dopamine receptor antagonist",0.42686,1.08,0.342,76,0.658,"UH.232...., clebopride, isofloxythepin, remoxipride",0.465973893943865,0.181774106386044,FALSE +"H1703","Pearson.est","estrogen receptor agonist",0.70992,1.84,0.0149,228,0.259,"levonorgestrel, estradiol.cypionate, erteberel, equol",1.82681373158773,0.586700235918748,FALSE +"H1703","Pearson.est","estrogen receptor antagonist",0.29114,0.751,0.787,420,0.826,"tamoxifen, toremifene, clomifene",0.104025267640935,0.0830199526796178,FALSE +"H1703","Pearson.est","FGFR inhibitor",-0.47648,-1.21,0.254,1378,0.57,"AZD4547, lucitanib",0.595166283380062,0.244125144327509,FALSE +"H1703","Pearson.est","FLT3 inhibitor",-0.28884,-0.729,0.772,1055,0.853,"sunitinib, pacritinib, ponatinib, tozasertib, KW.2449, sorafenib",0.112382699664264,0.069050968832477,FALSE +"H1703","Pearson.est","glucocorticoid receptor agonist",0.39257,1.04,0.395,454,0.662,"rimexolone, hydrocortisone, triamcinolone.acetonide, dexamethasone.acetate, piretanide, methylprednisolone, deflazacort, prednisolone, betamethasone, desonide, prednisolone.acetate, clobetasol.propionate, fluocinolone.acetonide",0.40340290437354,0.1791420105603,FALSE +"H1703","Pearson.est","glutamate receptor antagonist",0.24319,0.66,0.889,138,0.89,"diazooxonorleucine, JNJ.16259685, kynurenic.acid",0.0510982390297863,0.0506099933550872,FALSE +"H1703","Pearson.est","glycogen synthase kinase inhibitor",-0.38873,-0.998,0.443,1238,0.64,"TWS.119, indirubin, AZD2858",0.35359627377693,0.193820026016113,FALSE +"H1703","Pearson.est","growth factor receptor inhibitor",-0.49051,-1.24,0.228,1334,0.575,"PHA.848125, AZD3463",0.642065152999546,0.24033215531037,FALSE +"H1703","Pearson.est","HCV inhibitor",0.37486,0.984,0.435,298,0.667,"mericitabine, PSI.7976",0.361510743045363,0.175874166083451,FALSE +"H1703","Pearson.est","HDAC inhibitor",-0.44591,-1.13,0.311,1046,0.583,"resminostat, RG2833, SB.939, M.344, JNJ.26481585, ACY.1215, mocetinostat, entinostat, scriptaid, romidepsin, PCI.24781, panobinostat, trichostatin.a, AR.42, givinostat, dacinostat",0.507239610973163,0.234331445240986,FALSE +"H1703","Pearson.est","histamine receptor antagonist",0.45108,1.2,0.251,250,0.523,"chloropyramine, cimetidine, ranitidine, epinastine, nizatidine, cyproheptadine, terfenadine, ICI.162846",0.600326278518962,0.281498311132726,FALSE +"H1703","Pearson.est","HMGCR inhibitor",0.37795,0.989,0.432,903,0.689,"mevastatin, pitavastatin, atorvastatin, simvastatin, fluvastatin, lovastatin",0.364516253185088,0.161780778092374,FALSE +"H1703","Pearson.est","HSP inhibitor",-0.5752,-1.48,0.0982,1353,0.745,"VER.49009, tanespimycin, alvespimycin, ganetespib, NVP.AUY922",1.00788851221305,0.127843727251707,FALSE +"H1703","Pearson.est","JAK inhibitor",-0.27566,-0.689,0.825,1128,0.886,"pacritinib, AZ960, AT.9283, tozasertib, PRT062070",0.0835460514500749,0.0525662781129492,FALSE +"H1703","Pearson.est","KIT inhibitor",-0.3151,-0.806,0.709,1148,0.798,"regorafenib, vatalanib, telatinib, imatinib, KI.8751, sorafenib",0.149353764816933,0.0979971086492706,FALSE +"H1703","Pearson.est","MDM inhibitor",0.29334,0.749,0.776,1025,0.803,"nutlin.3, AMG.232, idasanutlin, serdemetan, RITA, CGM097",0.110138278741812,0.095284454721319,FALSE +"H1703","Pearson.est","MEK inhibitor",-0.50687,-1.28,0.213,1205,0.641,"selumetinib, arctigenin, MEK162, trametinib, PD.184352, cobimetinib, TAK.733, AZD8330, nobiletin",0.671620396561262,0.193141970481183,FALSE +"H1703","Pearson.est","MET inhibitor",-0.32364,-0.847,0.651,1335,0.755,"LY2801653",0.186419011431808,0.122053048370812,FALSE +"H1703","Pearson.est","microtubule inhibitor",-0.39711,-1.02,0.413,950,0.642,"vinblastine, D.64131, cabazitaxel, vinflunine, podophyllotoxin",0.384049948343599,0.192464971931147,FALSE +"H1703","Pearson.est","mTOR inhibitor",-0.60611,-1.52,0.0914,1062,0.938,"PF.04691502, WAY.600, deforolimus, PF.05212384, LY3023414, AZD8055, NVP.BEZ235, torin.2, everolimus, GDC.0980, WYE.354, temsirolimus, torin.1, OSI.027, PKI.179, GSK2126458, AZD2014, XL388, SB.2343, MLN0128",1.03905380426617,0.0277971616209356,FALSE +"H1703","Pearson.est","NFkB pathway inhibitor",-0.34838,-0.906,0.576,1402,0.696,"Ro.106.9920, bortezomib",0.239577516576788,0.157390760389438,FALSE +"H1703","Pearson.est","opioid receptor agonist",-0.29422,-0.759,0.756,1038,0.83,"trimebutine, salvinorin.a, ADL5859",0.121478204498793,0.0809219076239261,FALSE +"H1703","Pearson.est","p38 MAPK inhibitor",0.45973,1.2,0.278,316,0.523,"TAK.715, SB.242235, CMPD.1",0.555955204081924,0.281498311132726,FALSE +"H1703","Pearson.est","PARP inhibitor",-0.2416,-0.61,0.886,1272,0.95,"E7449",0.0525662781129492,0.0222763947111523,FALSE +"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.41536,-1.04,0.376,1146,0.629,"ponatinib, regorafenib, SU014813, vatalanib, telatinib, imatinib, KI.8751, axitinib, sorafenib, trapidil",0.424812155072339,0.201349354554731,FALSE +"H1703","Pearson.est","phosphatase inhibitor",-0.38598,-1,0.424,958,0.656,"AS.1949490, bis.maltolato.oxovanadium.IV., CID.5458317, mycophenolic.acid, BVT.948",0.372634143407267,0.18309616062434,FALSE +"H1703","Pearson.est","phosphodiesterase inhibitor",0.32783,0.841,0.612,153,0.771,"cilostamide, avanafil, papaverine",0.213248577854439,0.112945621949043,FALSE +"H1703","Pearson.est","PI3K inhibitor",-0.37692,-0.953,0.499,1057,0.676,"PI3K.IN.2, PF.04691502, PF.05212384, LY3023414, NVP.BEZ235, buparlisib, TG.100713, GDC.0980, PIK.75, BGT226, PKI.179, GSK2126458, SB.2343",0.30189945437661,0.170053304058364,FALSE +"H1703","Pearson.est","PLK inhibitor",-0.61196,-1.56,0.0575,1095,1,"BI.2536, volasertib, rigosertib, NMS.1286937, GSK461364",1.24033215531037,0,FALSE +"H1703","Pearson.est","potassium channel blocker",0.52065,1.35,0.165,38,0.429,"oleoylethanolamide, meglitinide",0.782516055786094,0.367542707815276,FALSE +"H1703","Pearson.est","PPAR receptor agonist",0.60299,1.57,0.0761,494,0.285,"oleoylethanolamide, GW.501516, S26948, ciprofibrate, clofibrate",1.11861534322943,0.54515513999149,FALSE +"H1703","Pearson.est","progesterone receptor agonist",0.60922,1.56,0.0697,263,0.264,"levonorgestrel, norethindrone.acetate, nomegestrol.acetate, tanaproget",1.15676722190199,0.578396073130169,FALSE +"H1703","Pearson.est","proteasome inhibitor",-0.48594,-1.26,0.208,1080,0.64,"ixazomib.citrate, ixazomib, carfilzomib, bortezomib",0.681936665037238,0.193820026016113,FALSE +"H1703","Pearson.est","protein synthesis inhibitor",-0.58266,-1.5,0.0836,1135,0.82,"cycloheximide, brefeldin.a, puromycin, florfenicol, anguidine, harringtonine, emetine, mercaptopurine, methacycline, thiostrepton, tedizolid.phosphate, homoharringtonine",1.07779372256098,0.0861861476162833,FALSE +"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.49453,-1.24,0.211,1023,0.575,"PP.121, BMS.599626, NVP.TAE226, tyrphostin.A9, AV.412, mubritinib",0.675717544702307,0.24033215531037,FALSE +"H1703","Pearson.est","RAF inhibitor",-0.45742,-1.16,0.277,1088,0.577,"LGX818, AZ.628, regorafenib, TAK.632, CEP.32496, sorafenib",0.557520230935551,0.238824186844269,FALSE +"H1703","Pearson.est","RET tyrosine kinase inhibitor",-0.42852,-1.09,0.33,1055,0.608,"sunitinib, regorafenib, sorafenib",0.481486060122112,0.216096420727265,FALSE +"H1703","Pearson.est","retinoid receptor agonist",0.56133,1.46,0.106,221,0.352,"adarotene, tamibarotene, adapalene",0.97469413473523,0.453457336521869,FALSE +"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.19767,-0.503,0.975,981,0.978,"clofarabine, gemcitabine, fludarabine, cladribine",0.0109953843014632,0.00966114521239857,FALSE +"H1703","Pearson.est","serotonin receptor agonist",0.62283,1.62,0.0509,144,0.262,"aripiprazole, NAN.190",1.29328221766324,0.581698708680255,FALSE +"H1703","Pearson.est","serotonin receptor antagonist",0.4441,1.23,0.197,51,0.586,"aripiprazole, SB.228357",0.705533773838407,0.232102383981909,FALSE +"H1703","Pearson.est","sodium channel blocker",0.3546,0.909,0.572,158,0.742,"oxcarbazepine, quinidine, benzethonium",0.242603971206976,0.129596094720973,FALSE +"H1703","Pearson.est","src inhibitor",0.30378,0.798,0.686,198,0.784,"dasatinib, PP.2, saracatinib",0.163675884293248,0.105683937315562,FALSE +"H1703","Pearson.est","sterol demethylase inhibitor",-0.53761,-1.36,0.142,1223,0.653,"sulconazole, terconazole, ketoconazole",0.847711655616944,0.185086818724926,FALSE +"H1703","Pearson.est","TGF beta receptor inhibitor",0.55192,1.44,0.0984,246,0.344,"D.4476, LY2109761",1.00700490156866,0.46344155742847,FALSE +"H1703","Pearson.est","thymidylate synthase inhibitor",-0.42487,-1.07,0.381,1217,0.618,"trifluridine, carmofur",0.419075024324381,0.209011524911184,FALSE +"H1703","Pearson.est","topoisomerase inhibitor",-0.45213,-1.16,0.277,1037,0.577,"valrubicin, amsacrine, teniposide, SN.38, camptothecin, daunorubicin, amonafide, nemorubicin, beta.lapachone, TAS.103",0.557520230935551,0.238824186844269,FALSE +"H1703","Pearson.est","tubulin polymerization inhibitor",-0.42507,-1.1,0.357,997,0.613,"BNC105, vindesine, fenbendazole, podophyllotoxin, fosbretabulin, epothilone.d, nocodazole, plinabulin, flubendazole, paclitaxel, epothilone.b, dolastatin.10, albendazole, docetaxel",0.447331783887807,0.212539525481585,FALSE +"H1703","Pearson.est","tyrosine kinase inhibitor",-0.3587,-0.912,0.54,1023,0.705,"PP.121, sunitinib, tyrphostin.AG.99, BMS.599626, NVP.TAE226, tyrphostin.A9, regorafenib, AV.412, AMG.208, sorafenib, mubritinib",0.267606240177031,0.151810883008601,FALSE +"H1703","Pearson.est","VEGFR inhibitor",-0.38476,-0.986,0.458,1105,0.641,"foretinib, tivozanib, regorafenib, SU014813, vatalanib, telatinib, KI.8751, axitinib, sorafenib, lucitanib, ZM.306416",0.339134521996131,0.193141970481183,FALSE +"H1703","Pearson.est","vitamin D receptor agonist",0.34282,0.895,0.531,954,0.737,"doxercalciferol, ercalcitriol, calcitriol, alfacalcidol, tacalcitol, paricalcitol, maxacalcitol",0.274905478918531,0.132532512140949,FALSE +"H1299","Pearson.est","EGFR inhibitor",-0.1354,-0.316,1,1241,1,"CUDC.101, ARRY.334543, BIBU.1361, AST.1306",0,0,FALSE +"H1299","Pearson.est","Abl kinase inhibitor",-0.36687,-0.856,0.675,972,0.925,"ZM.306416, flumatinib, nilotinib, bafetinib, imatinib, tozasertib, KW.2449",0.170696227168975,0.0338582672609674,FALSE +"H1299","Pearson.est","acetylcholine receptor agonist",-0.57095,-1.35,0.106,928,0.526,"oxiracetam, xanomeline, nefiracetam, pilocarpine",0.97469413473523,0.279014255846261,FALSE +"H1299","Pearson.est","acetylcholine receptor antagonist",0.58807,1.69,0.0442,600,0.171,"darifenacin, hyoscyamine, dicycloverine, iododexetimide, methscopolamine, diphemanil",1.35457773065091,0.767003889607846,TRUE +"H1299","Pearson.est","adenosine receptor antagonist",-0.38832,-0.915,0.603,799,0.879,"SCH.58261, istradefylline, MRS.1220, CGS.15943, PSB.1115",0.219682687859849,0.0560111249262281,FALSE +"H1299","Pearson.est","adrenergic receptor agonist",0.28751,0.849,0.615,1036,0.736,"lidamidine, terbutaline, ritodrine, oxymetazoline, xylazine, epinephrine, isoetharine, isoxsuprine, A61603, metaraminol, methyldopa, norepinephrine, buphenine, clenbuterol, midodrine",0.211124884224583,0.133122185662501,FALSE +"H1299","Pearson.est","adrenergic receptor antagonist",-0.20531,-0.488,0.987,861,1,"propranolol, idazoxan, dihydroergocristine, carvedilol, naftidrofuryl, atipamezole, oxprenolol",0.00568284733036327,0,FALSE +"H1299","Pearson.est","AKT inhibitor",-0.4995,-1.18,0.261,856,0.764,"CCT128930, palomid.529, MK.2206, AZD5363, ONC201, triciribine, A.674563, uprosertib",0.583359492661719,0.11690664142431,FALSE +"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.16532,-0.393,0.997,968,1,"CEP.37440, AZD3463, DMH1",0.00130484168834428,0,FALSE +"H1299","Pearson.est","androgen receptor antagonist",0.61026,1.83,0.0373,568,0.139,"RU.58841, bicalutamide, nilutamide, flutamide, cyproterone.acetate, enzalutamide",1.42829116819131,0.856985199745905,TRUE +"H1299","Pearson.est","antioxidant",-0.44115,-1.03,0.436,753,0.836,"chlorogenic.acid, benfotiamine, trolox, taurine",0.360513510731414,0.0777937225609836,FALSE +"H1299","Pearson.est","AP inhibitor",0.45452,1.31,0.13,51,0.468,"birinapant, GDC.0152",0.886056647693163,0.329754146925876,FALSE +"H1299","Pearson.est","ATPase inhibitor",0.28202,0.851,0.586,5,0.795,"k.strophanthidin, ouabain",0.232102383981909,0.0996328713435297,FALSE +"H1299","Pearson.est","Aurora kinase inhibitor",-0.63714,-1.49,0.0409,1048,0.355,"CYC116, PF.03814735, barasertib, PHA.680632, GSK1070916, alisertib, tozasertib, danusertib, MK.8745, AMG900, KW.2449, ENMD.2076, barasertib.HQPA, AT.9283, SNS.314, hesperadin, CCT137690, ZM.447439",1.38827669199266,0.449771646944906,FALSE +"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.44904,-1.06,0.395,749,0.779,"josamycin, tedizolid, radezolid, azalomycin.b, valnemulin",0.40340290437354,0.108462542327436,FALSE +"H1299","Pearson.est","bacterial DNA gyrase inhibitor",0.34918,1.04,0.4,238,0.725,"sparfloxacin, sarafloxacin, trovafloxacin, lomefloxacin, novobiocin",0.397940008672038,0.139661993429006,FALSE +"H1299","Pearson.est","BCL inhibitor",-0.46518,-1.08,0.346,914,0.824,"ABT.737, obatoclax, venetoclax, gossypol, TW.37",0.460923901207223,0.0840727883028842,FALSE +"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.34818,-0.807,0.771,1069,0.94,"flumatinib, nilotinib, bafetinib, imatinib, tozasertib",0.112945621949043,0.0268721464003014,FALSE +"H1299","Pearson.est","benzodiazepine receptor agonist",0.24226,0.693,0.845,160,0.852,"gamma.aminobutyric.acid, eprinomectin, CL.218872, temazepam",0.0731432910503077,0.0695604052332999,FALSE +"H1299","Pearson.est","bromodomain inhibitor",-0.9362,-2.2,0,1350,0,"I.BET.762, bromosporine, JQ1...., PFI.1, I.BET151, OTX015",Inf,Inf,TRUE +"H1299","Pearson.est","calcium channel blocker",-0.43836,-1.02,0.446,852,0.839,"fendiline, penfluridol, mibefradil, tetrandrine, SR.33805, carboxyamidotriazole",0.350665141287858,0.0762380391712997,FALSE +"H1299","Pearson.est","CC chemokine receptor antagonist",-0.47216,-1.12,0.309,782,0.766,"PF.04136309, RS.504393, MK.0812, navarixin, ZK811752, SB.225002",0.510041520575165,0.115771230367396,FALSE +"H1299","Pearson.est","CDK inhibitor",-0.74249,-1.76,0.00558,1218,0.119,"indirubin, BMS.265246, indisulam, arcyriaflavin.a, JNJ.7706621, PHA.793887, alvocidib, BMS.387032, AT.7519, AZD5438, kenpaullone, P276.00, TG.02, ribociclib, abemaciclib, palbociclib, dinaciclib",2.25336580106242,0.924453038607469,TRUE +"H1299","Pearson.est","CHK inhibitor",0.30143,0.912,0.593,125,0.823,"SCH.900776, CHIR.124",0.226945306635737,0.0846001647877302,FALSE +"H1299","Pearson.est","cyclooxygenase inhibitor",-0.19078,-0.454,0.99,979,1,"tryptanthrin, piroxicam, ramifenazone, ketoprofen, FR.122047, aspirin",0.00436480540245009,0,FALSE +"H1299","Pearson.est","cytochrome P450 inhibitor",0.34293,0.948,0.451,184,0.833,"eplerenone, morin, metyrapone",0.345823458122039,0.0793549985932124,FALSE +"H1299","Pearson.est","DNA alkylating agent",-0.47884,-1.13,0.304,1033,0.824,"cyclophosphamide, TH.302, melphalan, estramustine, streptozotocin, mitomycin.c",0.517126416391246,0.0840727883028842,FALSE +"H1299","Pearson.est","DNA inhibitor",-0.42701,-0.994,0.474,1062,0.798,"valrubicin, mechlorethamine, melphalan, teroxirone, pibenzimol, oxaliplatin, primaquine",0.324221658325915,0.0979971086492706,FALSE +"H1299","Pearson.est","DNA methyltransferase inhibitor",-0.51029,-1.2,0.236,958,0.768,"decitabine, SGI.1027, azacitidine, fdcyd",0.627087997029893,0.114638779968488,FALSE +"H1299","Pearson.est","DNA polymerase inhibitor",-0.50446,-1.18,0.247,1162,0.764,"cephalomannine, trifluridine, idoxuridine",0.607303046740334,0.11690664142431,FALSE +"H1299","Pearson.est","DNA synthesis inhibitor",-0.42814,-0.996,0.495,1119,0.834,"floxuridine, anisomycin, cyclocytidine, mitomycin.c",0.305394801066431,0.0788339493622613,FALSE +"H1299","Pearson.est","dopamine receptor antagonist",-0.40914,-0.954,0.549,969,0.851,"oxiperomide, acetophenazine, paliperidone, lurasidone, thioproperazine, UH.232...., raclopride, sertindole",0.260427655549908,0.0700704399154121,FALSE +"H1299","Pearson.est","estrogen receptor agonist",0.29861,0.874,0.647,1018,0.825,"estradiol.cypionate, levonorgestrel, ethinyl.estradiol, equol, PPT, erteberel, estradiol, estrone",0.1890957193313,0.0835460514500749,FALSE +"H1299","Pearson.est","estrogen receptor antagonist",-0.41381,-0.971,0.507,667,0.833,"toremifene, fulvestrant, danazol, raloxifene, clomifene",0.294992040666664,0.0793549985932124,FALSE +"H1299","Pearson.est","FGFR inhibitor",-0.52777,-1.24,0.172,1373,0.713,"lucitanib, regorafenib",0.764471553092451,0.146910470148134,FALSE +"H1299","Pearson.est","FLT3 inhibitor",-0.684,-1.6,0.0168,1279,0.209,"tozasertib, GTP.14564, lestaurtinib, TG.02, KW.2449, ENMD.2076, pacritinib, sorafenib",1.77469071827414,0.679853713888946,TRUE +"H1299","Pearson.est","glucocorticoid receptor agonist",-0.36562,-0.871,0.644,653,0.932,"halcinonide, prednisolone.hemisuccinate, methylprednisolone, difluprednate, dexamethasone.acetate, fluticasone.propionate, ciclesonide, triamcinolone, flumethasone, halobetasol.propionate, betamethasone, fludroxycortide, deflazacort, prednisolone, rimexolone, flumethasone.pivalate",0.191114132640188,0.0305840876460186,FALSE +"H1299","Pearson.est","glutamate receptor antagonist",0.38767,1.18,0.248,31,0.525,"CGP.37849, latrepirdine, JNJ.16259685",0.605548319173784,0.279840696594043,FALSE +"H1299","Pearson.est","glycogen synthase kinase inhibitor",-0.37663,-0.891,0.611,1003,0.91,"AZD2858, GSK.3.inhibitor.IX, indirubin, kenpaullone",0.213958789757446,0.0409586076789064,FALSE +"H1299","Pearson.est","growth factor receptor inhibitor",-0.72519,-1.71,0.00797,1045,0.145,"PHA.848125, GSK1904529A, AZD3463, GW.441756, lestaurtinib, GSK1838705A, danusertib",2.09854167860389,0.838631997765025,TRUE +"H1299","Pearson.est","HCV inhibitor",-0.43708,-1.01,0.457,1109,0.82,"mericitabine, narlaprevir",0.34008379993015,0.0861861476162833,FALSE +"H1299","Pearson.est","HDAC inhibitor",-0.57867,-1.37,0.108,1150,0.548,"AR.42, entinostat, ACY.1215, PCI.24781, R306465, RG2833, givinostat, SB.939, belinostat, scriptaid, resminostat, vorinostat, dacinostat, trichostatin.a, M.344",0.96657624451305,0.261219441515631,FALSE +"H1299","Pearson.est","histamine receptor antagonist",-0.2599,-0.613,0.94,635,1,"chloropyramine, epinastine, ebastine, famotidine, lafutidine, pheniramine, cyproheptadine, BF2.649, astemizole, levocetirizine, terfenadine, tiotidine",0.0268721464003014,0,FALSE +"H1299","Pearson.est","HMGCR inhibitor",0.83548,2.61,0,209,0,"simvastatin, pitavastatin, fluvastatin, atorvastatin, lovastatin",Inf,Inf,TRUE +"H1299","Pearson.est","HSP inhibitor",-0.42578,-0.995,0.492,895,0.816,"NMS.E973, SNX.5422, NVP.AUY922, PU.H71, alvespimycin, XL888, tanespimycin",0.30803489723264,0.0883098412461389,FALSE +"H1299","Pearson.est","JAK inhibitor",-0.45317,-1.06,0.395,905,0.779,"LY2784544, WHI.P154, TG.101348, TG.101209, PRT062070, AZ960, atiprimod, tozasertib, lestaurtinib, TG.02, AT.9283, pacritinib",0.40340290437354,0.108462542327436,FALSE +"H1299","Pearson.est","KIT inhibitor",-0.48019,-1.12,0.306,1208,0.766,"imatinib, KI.8751, pazopanib, regorafenib, OSI.930, sorafenib",0.51427857351842,0.115771230367396,FALSE +"H1299","Pearson.est","MDM inhibitor",-0.54903,-1.29,0.143,843,0.628,"idasanutlin, RITA, CGM097, nutlin.3, serdemetan",0.844663962534938,0.202040356262804,FALSE +"H1299","Pearson.est","MEK inhibitor",-0.48424,-1.12,0.308,825,0.766,"BIX.02188, nobiletin, Ro.4987655, PD.198306, selumetinib, PD.184352, refametinib, cobimetinib, trametinib, PD.318088, AZD8330, arctigenin, PD.98059, TAK.733, PD.0325901, MEK162",0.511449283499556,0.115771230367396,FALSE +"H1299","Pearson.est","MET inhibitor",-0.36365,-0.853,0.685,1227,0.912,"AMG458",0.164309428507574,0.0400051616715838,FALSE +"H1299","Pearson.est","microtubule inhibitor",-0.5908,-1.4,0.0763,1175,0.557,"colchicine, cabazitaxel, vinflunine, podophyllotoxin, D.64131",1.11747546204512,0.254144804826271,FALSE +"H1299","Pearson.est","mTOR inhibitor",-0.29231,-0.683,0.877,1144,1,"WYE.125132, GSK2126458, AZD8055, AZD2014, LY303511, XL388",0.0570004066339595,0,FALSE +"H1299","Pearson.est","NFkB pathway inhibitor",-0.53389,-1.27,0.162,1029,0.658,"tyloxapol, bortezomib, IKK.2.inhibitor.V, Ro.106.9920, betulinic.acid, parthenolide...., EVP4593",0.790484985457369,0.181774106386044,FALSE +"H1299","Pearson.est","opioid receptor agonist",0.28777,0.824,0.654,123,0.721,"BW.180C, spiradoline",0.184422251675733,0.142064735280571,FALSE +"H1299","Pearson.est","p38 MAPK inhibitor",-0.48789,-1.14,0.296,955,0.825,"SB.242235, skepinone.l, SB.239063, talmapimod",0.528708288941061,0.0835460514500749,FALSE +"H1299","Pearson.est","PARP inhibitor",-0.46651,-1.08,0.378,717,0.824,"AZD2461, AG.14361, E7449, PJ.34, olaparib, niraparib, talazoparib",0.422508200162775,0.0840727883028842,FALSE +"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.33325,-0.783,0.78,967,0.944,"SU014813, vatalanib, axitinib, crenolanib, trapidil, imatinib, KI.8751, pazopanib, regorafenib, sorafenib",0.10790539730952,0.025028005701931,FALSE +"H1299","Pearson.est","phosphatase inhibitor",-0.32763,-0.771,0.777,1242,0.945,"GSK2830371, CID.5458317",0.109578981199086,0.0245681914907371,FALSE +"H1299","Pearson.est","phosphodiesterase inhibitor",-0.36128,-0.843,0.712,1063,0.913,"papaverine, trequinsin",0.147520006363144,0.039529222465701,FALSE +"H1299","Pearson.est","PI3K inhibitor",-0.22402,-0.524,0.973,1160,1,"GSK2126458, CUDC.907, LY303511, PIK.75",0.0118871597316481,0,FALSE +"H1299","Pearson.est","PLK inhibitor",-0.7703,-1.8,0.00228,1110,0.117,"NMS.1286937, HMN.214, volasertib, rigosertib, GSK461364, BI.2536, GW.843682X",2.64206515299955,0.931814138253838,TRUE +"H1299","Pearson.est","potassium channel blocker",0.42711,1.26,0.179,84,0.466,"ibutilide, dofetilide, mepivacaine",0.747146969020107,0.33161408331,FALSE +"H1299","Pearson.est","PPAR receptor agonist",-0.26789,-0.619,0.928,930,1,"ciprofibrate, oleoylethanolamide, GW.501516",0.0324520237811379,0,FALSE +"H1299","Pearson.est","progesterone receptor agonist",-0.36785,-0.864,0.682,838,0.928,"danazol, tanaproget, norethindrone, dienogest, melengestrol.acetate",0.166215625343521,0.0324520237811379,FALSE +"H1299","Pearson.est","proteasome inhibitor",-0.3152,-0.739,0.824,540,0.97,"delanzomib, MG.132, carfilzomib, ixazomib.citrate, bortezomib, ixazomib",0.0840727883028842,0.0132282657337552,FALSE +"H1299","Pearson.est","protein synthesis inhibitor",-0.43532,-1.01,0.464,769,0.82,"methacycline, azomycin..2.nitroimidazole., cycloheximide, puromycin, emetine, brefeldin.a, tedizolid.phosphate, mercaptopurine, harringtonine, thiostrepton, homoharringtonine, anguidine, bruceantin",0.333482019445119,0.0861861476162833,FALSE +"H1299","Pearson.est","protein tyrosine kinase inhibitor",-0.56209,-1.32,0.136,1297,0.576,"mubritinib, tyrphostin.A9, NVP.TAE226",0.866461091629782,0.239577516576788,FALSE +"H1299","Pearson.est","RAF inhibitor",-0.67795,-1.6,0.0246,1180,0.209,"SB.590885, AZ.628, GDC.0879, PLX.4720, CEP.32496, regorafenib, RAF265, TAK.632, sorafenib",1.60906489289662,0.679853713888946,TRUE +"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.66807,-1.57,0.029,1398,0.229,"regorafenib, sorafenib",1.53760200210104,0.640164517660112,TRUE +"H1299","Pearson.est","retinoid receptor agonist",-0.21554,-0.509,0.984,600,1,"adapalene, fenretinide, tamibarotene, adarotene, bexarotene",0.00700490156865849,0,FALSE +"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.3336,-0.785,0.776,1037,0.958,"fludarabine, clofarabine, cladribine",0.110138278741812,0.0186344909214556,FALSE +"H1299","Pearson.est","serotonin receptor agonist",-0.68558,-1.6,0.0191,1264,0.209,"zolmitriptan, aripiprazole",1.71896663275227,0.679853713888946,TRUE +"H1299","Pearson.est","serotonin receptor antagonist",-0.52057,-1.21,0.233,1027,0.776,"paliperidone, lurasidone, SB.228357, SB.216641, sertindole, aripiprazole",0.632644078973981,0.110138278741812,FALSE +"H1299","Pearson.est","sodium channel blocker",-0.39093,-0.921,0.578,890,0.885,"brivaracetam, quinidine, A.803467, triamterene, lappaconite, ajmaline, benzethonium",0.238072161579471,0.0530567293021746,FALSE +"H1299","Pearson.est","src inhibitor",0.45082,1.35,0.18,11,0.507,"dasatinib, saracatinib",0.744727494896694,0.294992040666664,FALSE +"H1299","Pearson.est","sterol demethylase inhibitor",-0.40245,-0.942,0.578,1200,0.859,"chlormidazole",0.238072161579471,0.0660068361687577,FALSE +"H1299","Pearson.est","TGF beta receptor inhibitor",-0.29435,-0.681,0.885,1080,1,"SB.525334, D.4476",0.0530567293021746,0,FALSE +"H1299","Pearson.est","thymidylate synthase inhibitor",-0.59114,-1.39,0.0844,1251,0.536,"carmofur, trifluridine, raltitrexed",1.07365755337434,0.27083521030723,FALSE +"H1299","Pearson.est","topoisomerase inhibitor",-0.49371,-1.17,0.265,872,0.762,"rubitecan, dexrazoxane, doxorubicin, irinotecan, teniposide, licochalcone.a, camptothecin, daunorubicin, idarubicin, valrubicin, SN.38, amonafide, etoposide, genz.644282, voreloxin, exatecan.mesylate, beta.lapachone, TAS.103",0.576754126063192,0.1180450286604,FALSE +"H1299","Pearson.est","tubulin polymerization inhibitor",-0.58691,-1.35,0.105,1127,0.526,"vindesine, paclitaxel, dolastatin.10, parbendazole, combretastatin.A.4, docetaxel, ABT.751, plinabulin, vincristine, podophyllotoxin, flubendazole, vinorelbine, KX2.391, CYT.997, albendazole, nocodazole, taltobulin, fosbretabulin",0.978810700930062,0.279014255846261,FALSE +"H1299","Pearson.est","tyrosine kinase inhibitor",-0.4499,-1.06,0.406,1132,0.779,"aminopurvalanol.a, bafetinib, tivantinib, GTP.14564, mubritinib, tyrphostin.A9, UNC2250, NVP.TAE226, regorafenib, sorafenib",0.391473966422806,0.108462542327436,FALSE +"H1299","Pearson.est","VEGFR inhibitor",-0.46131,-1.07,0.364,1268,0.826,"KI.8751, pazopanib, golvatinib, lucitanib, regorafenib, ENMD.2076, RAF265, OSI.930, sorafenib",0.438898616350944,0.0830199526796178,FALSE +"H1299","Pearson.est","vitamin D receptor agonist",-0.34947,-0.814,0.75,845,0.946,"ercalcitriol, doxercalciferol, tacalcitol",0.1249387366083,0.0241088635982073,FALSE diff --git a/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_venn_diagram.pdf b/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_venn_diagram.pdf new file mode 100644 index 0000000000000000000000000000000000000000..e41388488fbf0018b6387a0903540fca20ffb154 GIT binary patch literal 7615 zcmZ{pc{tST`^PQWMX0PXgeZ&|>)7{w-?L9+Fk*%=vJT3=O(a{kWQ{Z=*|H^D){s4f zk}cWS^c$ViIp_O5zwhU-dETG^Sa)AMrsW*>&0F9t7aBqMZA;1LicY@Tv63*hzqS0_9=Ff1TDhi1qEWH8J zztVvwaBq|k8b;Vp{J-`)3-~<_Jvh<@;|dTXoE-qvK)7QFCje@=6NaM(hoPL{XMKBP z2s87b_RCtg(Z}0qGEC1pcu8t?e{rf0RH&&02rz23rdshnBOzAz;{ATF+0cBK<5<3j zWVS}NK90q(KRYAmw4^kL`%X~c_~!QJz?3i7DdgSFcMPjLcXq(iC5<^gSAHH%Z7wa0 zONH#cB+zZuR3VNVXebqId$Qq&J=I^G=1yzfsZ`)2LgwqM|O4yGCN_xzhk~O&0C1$%B%!3BC_L6&^H%R_m}yX$IB{#{dhiuv4F^p z?-mG`+KvdO+siIvzIwJ!+Z#{zoQA>wD) zr}#nXbAtvjvT&^^kzoP&-tXFP#zdkkx5>?ErEI1LwfS*IKEPU4#!VW|U7tB)B50 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+ + + + diff --git a/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_mean_results.csv b/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_mean_results.csv new file mode 100644 index 0000000..202eb0d --- /dev/null +++ b/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_mean_results.csv @@ -0,0 +1,3 @@ +"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"alpha amino acids",0.0387499999999999,1.14799573055322,0.189915440401228,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"CALU3, H520",0.189915440401228 +"acyl carnitines",-0.22335,1.33176603267596,0.00112427633817813,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"H2126, HCC2279, H460",0.00224855267635625 diff --git a/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_results.csv b/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_results.csv new file mode 100644 index 0000000..afb5bf8 --- /dev/null +++ b/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_results.csv @@ -0,0 +1,41 @@ +"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"H358","Input","alpha amino acids",-0.28972,-1.03,0.4,62,0.39,"sarcosine, homocysteine, glycine, citrulline, dimethylglycine, creatinine, betaine, acetylglycine, ornithine, phosphocreatine, creatine",0.397940008672038,0.408935392973501,FALSE +"H358","Input","acyl carnitines",-0.38991,-1.41,0.133,85,0.254,"propionylcarnitine, heptanoylcarnitine, stearoylcarnitine, malonylcarnitine, hexanoylcarnitine, palmitoylcarnitine, myristoylcarnitine",0.876148359032914,0.595166283380062,FALSE +"H1650","Input","alpha amino acids",-0.41638,-1.5,0.0821,173,0.076,"glycine, creatinine, betaine, ornithine, dimethylglycine, creatine, citrulline",1.08565684288056,1.11918640771921,FALSE +"H1650","Input","acyl carnitines",0.36239,1.3,0.167,146,0.173,"hexanoylcarnitine, myristoylcarnitine, heptanoylcarnitine, malonylcarnitine, palmitoylcarnitine, stearoylcarnitine, propionylcarnitine",0.777283528852417,0.761953896871205,FALSE +"HCC95","Input","alpha amino acids",-0.26711,-0.937,0.505,79,0.509,"homocysteine, creatine, glycine, citrulline, creatinine, dimethylglycine, betaine, sarcosine, acetylglycine, ornithine",0.296708621881339,0.293282217663241,FALSE +"HCC95","Input","acyl carnitines",-0.38991,-1.37,0.138,85,0.248,"stearoylcarnitine, propionylcarnitine, palmitoylcarnitine, myristoylcarnitine, malonylcarnitine, heptanoylcarnitine, hexanoylcarnitine",0.860120913598763,0.605548319173784,FALSE +"H3255","Input","alpha amino acids",0.33475,1.14,0.31,115,0.3,"homocysteine, creatine, acetylglycine, sarcosine, glycine, citrulline, dimethylglycine, creatinine, betaine",0.508638306165727,0.522878745280338,FALSE +"H3255","Input","acyl carnitines",-0.35088,-1.26,0.185,179,0.195,"propionylcarnitine, myristoylcarnitine, stearoylcarnitine, palmitoylcarnitine",0.732828271596986,0.709965388637482,FALSE +"H1648","Input","alpha amino acids",0.21893,0.77,0.736,40,0.739,"phosphocreatine, creatine, creatinine, glycine",0.133122185662501,0.131355561605174,FALSE +"H1648","Input","acyl carnitines",0.25529,0.885,0.59,13,1,"palmitoylcarnitine, myristoylcarnitine",0.229147988357856,0,FALSE +"H1975","Input","alpha amino acids",0.30803,1.07,0.368,39,0.365,"homocysteine, creatinine, dimethylglycine, phosphocreatine, ornithine",0.434152181326482,0.437707135543525,FALSE +"H1975","Input","acyl carnitines",-0.41428,-1.44,0.0909,125,0.0932,"heptanoylcarnitine, hexanoylcarnitine, malonylcarnitine, stearoylcarnitine, myristoylcarnitine, palmitoylcarnitine",1.04143611677803,1.03058408764602,FALSE +"HCC78","Input","alpha amino acids",-0.28078,-1,0.435,103,0.891,"phosphocreatine, citrulline, dimethylglycine, creatinine, homocysteine, betaine, creatine, ornithine, acetylglycine",0.361510743045363,0.0501222959631252,FALSE +"HCC78","Input","acyl carnitines",-0.27409,-0.976,0.471,126,0.474,"hexanoylcarnitine, myristoylcarnitine, palmitoylcarnitine, stearoylcarnitine, heptanoylcarnitine",0.326979092871104,0.324221658325915,FALSE +"H2126","Input","alpha amino acids",-0.28519,-1.01,0.415,104,0.417,"betaine, phosphocreatine, homocysteine, sarcosine, creatine, creatinine, dimethylglycine, citrulline, ornithine",0.381951903287907,0.379863945026242,FALSE +"H2126","Input","acyl carnitines",-0.50072,-1.79,0.0204,178,0.0494,"heptanoylcarnitine, myristoylcarnitine, propionylcarnitine, palmitoylcarnitine, stearoylcarnitine",1.6903698325741,1.30627305107635,TRUE +"HCC827","Input","alpha amino acids",0.26472,0.941,0.498,149,0.51,"ornithine, phosphocreatine, sarcosine, dimethylglycine, creatinine, glycine, creatine, homocysteine, betaine, citrulline",0.302770657240282,0.292429823902064,FALSE +"HCC827","Input","acyl carnitines",-0.15596,-0.563,0.929,34,0.945,"malonylcarnitine, heptanoylcarnitine, propionylcarnitine, hexanoylcarnitine, myristoylcarnitine, stearoylcarnitine, palmitoylcarnitine",0.0319842860063582,0.0245681914907371,FALSE +"CALU3","Input","alpha amino acids",-0.44662,-1.61,0.0475,163,0.0506,"sarcosine, creatine, dimethylglycine, betaine, citrulline, creatinine, glycine, phosphocreatine",1.32330639037513,1.2958494831602,TRUE +"CALU3","Input","acyl carnitines",0.34173,1.17,0.256,62,0.263,"palmitoylcarnitine, myristoylcarnitine, hexanoylcarnitine, stearoylcarnitine",0.59176003468815,0.580044251510242,FALSE +"H2009","Input","alpha amino acids",-0.30219,-1.05,0.403,150,0.795,"betaine, ornithine, creatinine, citrulline, sarcosine, dimethylglycine, homocysteine",0.39469495385889,0.0996328713435297,FALSE +"H2009","Input","acyl carnitines",-0.23817,-0.843,0.622,87,0.637,"stearoylcarnitine, palmitoylcarnitine, heptanoylcarnitine, myristoylcarnitine, propionylcarnitine, hexanoylcarnitine",0.206209615309181,0.19586056766465,FALSE +"HCC4006","Input","alpha amino acids",0.24766,0.856,0.594,172,0.592,"sarcosine, glycine, betaine, creatine, acetylglycine, ornithine, phosphocreatine, creatinine, homocysteine, citrulline, dimethylglycine",0.226213555018806,0.22767829327708,FALSE +"HCC4006","Input","acyl carnitines",-0.30744,-1.12,0.282,100,0.3,"stearoylcarnitine, hexanoylcarnitine, propionylcarnitine, malonylcarnitine, palmitoylcarnitine, heptanoylcarnitine",0.549750891680639,0.522878745280338,FALSE +"HCC2279","Input","alpha amino acids",-0.23263,-0.847,0.609,136,0.63,"betaine, creatinine, acetylglycine, glycine, creatine, sarcosine, phosphocreatine",0.215382707367125,0.200659450546418,FALSE +"HCC2279","Input","acyl carnitines",0.55124,1.88,0.0146,75,0.0143,"stearoylcarnitine, palmitoylcarnitine, myristoylcarnitine, propionylcarnitine, malonylcarnitine, hexanoylcarnitine",1.83564714421556,1.84466396253494,TRUE +"H520","Input","alpha amino acids",0.55543,1.96,0.00916,69,0.0145,"homocysteine, phosphocreatine, sarcosine, betaine, creatinine, ornithine, dimethylglycine, creatine, glycine",2.03810452633215,1.83863199776503,TRUE +"H520","Input","acyl carnitines",0.37677,1.34,0.16,115,0.152,"hexanoylcarnitine, malonylcarnitine, myristoylcarnitine, propionylcarnitine, heptanoylcarnitine, palmitoylcarnitine",0.795880017344075,0.818156412055227,FALSE +"HCC15","Input","alpha amino acids",-0.19164,-0.689,0.825,64,0.828,"ornithine, creatinine, dimethylglycine, acetylglycine, sarcosine, betaine, citrulline, glycine, creatine, phosphocreatine",0.0835460514500749,0.0819696632151199,FALSE +"HCC15","Input","acyl carnitines",0.37551,1.32,0.156,112,0.161,"myristoylcarnitine, palmitoylcarnitine, hexanoylcarnitine, stearoylcarnitine, malonylcarnitine, propionylcarnitine",0.806875401645538,0.79317412396815,FALSE +"H460","Input","alpha amino acids",0.33725,1.17,0.255,134,0.271,"homocysteine, phosphocreatine, sarcosine, creatine, dimethylglycine, creatinine, citrulline, ornithine, glycine, betaine",0.593459819566045,0.567030709125594,FALSE +"H460","Input","acyl carnitines",-0.46083,-1.68,0.0486,208,0.0435,"myristoylcarnitine, heptanoylcarnitine, palmitoylcarnitine, stearoylcarnitine",1.31336373073771,1.36151074304536,TRUE +"A549","Input","alpha amino acids",0.14945,0.524,0.976,74,0.977,"ornithine, glycine, citrulline, sarcosine, homocysteine",0.0105501823333082,0.0101054362812269,FALSE +"A549","Input","acyl carnitines",0.42635,1.51,0.0624,39,0.148,"propionylcarnitine, malonylcarnitine, hexanoylcarnitine, stearoylcarnitine",1.20481541031758,0.829738284605043,FALSE +"HCC44","Input","alpha amino acids",0.44653,1.57,0.0694,111,0.0644,"homocysteine, phosphocreatine, creatinine, sarcosine, dimethylglycine, ornithine, creatine, glycine, betaine, citrulline",1.15864052954514,1.19111413264019,FALSE +"HCC44","Input","acyl carnitines",-0.26991,-0.97,0.465,192,0.455,"myristoylcarnitine, stearoylcarnitine, palmitoylcarnitine",0.332547047110046,0.341988603342888,FALSE +"H1703","Input","alpha amino acids",-0.16231,-0.573,0.942,182,0.943,"dimethylglycine, ornithine, betaine, sarcosine",0.0259490972071227,0.0254883072626717,FALSE +"H1703","Input","acyl carnitines",0.32084,1.13,0.302,124,0.296,"propionylcarnitine, hexanoylcarnitine, palmitoylcarnitine, myristoylcarnitine, malonylcarnitine, stearoylcarnitine",0.519993057042849,0.528708288941061,FALSE +"H1299","Input","alpha amino acids",0.29166,1.02,0.425,143,0.425,"homocysteine, sarcosine, citrulline, phosphocreatine, glycine, ornithine, creatinine, dimethylglycine, acetylglycine, betaine",0.371611069949688,0.371611069949688,FALSE +"H1299","Input","acyl carnitines",-0.44634,-1.58,0.0767,200,0.0613,"myristoylcarnitine, stearoylcarnitine, palmitoylcarnitine, heptanoylcarnitine",1.11520463605102,1.21253952548158,FALSE diff --git a/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_venn_diagram.pdf b/Examples/cell_corr/Fig6 - Coldren 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zz?GZuzd;I2A>fCoSvmt#0$hhHx%{c41crEk5f0XtxS)UJLU$$7f4vgs1q0jSa?|nf z;&T7b51pWZ0G|MzE#3c=@d6GB=7$dYKV>|EfVcE-Wjx$M{J@U=N0~71f7cTc`p^D& zc(}O%SLxr{a&z(JaQ`1j C+rk?F literal 0 HcmV?d00001 diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_interactive_network.graph.html b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_interactive_network.graph.html new file mode 100644 index 0000000..defcaa3 --- /dev/null +++ b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_interactive_network.graph.html @@ -0,0 +1,5318 @@ + + + + +visNetwork + + + + + + + +
+
+
+ + + + diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_mean_results.csv b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..ab877c7 --- /dev/null +++ b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"cytochrome P450 inhibitor",0.876666666666667,1.00088672806879,0.0086732059516819,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC95, H460",0.0479917395993065 +"acetylcholine receptor agonist",0.84,0.981875200364542,0.0187649104580172,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1650, H1648",0.0819730298955488 +"p38 MAPK inhibitor",0.838083333333333,0.864376334110147,0.103470892747094,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.265858053738951 +"NFkB pathway inhibitor",0.7805,0.794129082706332,0.317938570821485,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.57367176909094 +"FGFR inhibitor",0.674416666666667,1.21420317742156,0.00447307638995378,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1975, HCC44",0.030938778363847 +"serotonin receptor antagonist",0.651166666666667,1.08345120570864,0.0627786803196693,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.19298631357528 +"RET tyrosine kinase inhibitor",0.644416666666667,1.11701025130262,0.0364862884683016,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.137652815584956 +"benzodiazepine receptor agonist",0.6175,0.685363805182726,0.912639505388095,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101 +"TGF beta receptor inhibitor",0.525916666666667,1.25066109487839,0.00662065423596996,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC15",0.0412925122398183 +"opioid receptor agonist",0.521583333333333,1.0187109910732,0.304889601260715,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.563896132065115 +"HMGCR inhibitor",0.471833333333333,1.68930549652988,8.88527761264178e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"HCC95, H1648, H520, H460, H1703",0.000737478041849268 +"sodium channel blocker",0.466166666666667,0.74089943291716,0.979145061559025,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995101540024098 +"PPAR receptor agonist",0.387333333333333,1.34340221644581,0.00283885002824505,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, H460",0.0214204138494854 +"ALK tyrosine kinase receptor inhibitor",0.38225,1.06331404109981,0.387162880759495,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.642690382060762 +"ATPase inhibitor",0.349083333333333,1.20677183640965,0.0779912864289485,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.231188456200097 +"PARP inhibitor",0.3195,1.13556837991138,0.184433352021348,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.43167357234584 +"glycogen synthase kinase inhibitor",0.303333333333333,0.982268833164354,0.718799968916346,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.956759865623637 +"KIT inhibitor",0.297583333333333,1.14045879590256,0.223209326253665,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.443410599485832 +"proteasome inhibitor",0.296916666666667,1.18114993724016,0.104955152106426,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.265858053738951 +"calcium channel blocker",0.292666666666667,0.914596317640971,0.916338688797989,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101 +"FLT3 inhibitor",0.281,0.964007544293376,0.827608248971204,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101 +"phosphatase inhibitor",0.276833333333333,0.989890153073317,0.726215319690231,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.956759865623637 +"PDGFR tyrosine kinase receptor inhibitor",0.263916666666667,1.01934350159425,0.675381696632086,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.91896198066333 +"RAF inhibitor",0.244916666666667,1.07575406604208,0.479705052937464,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.7239185344329 +"VEGFR inhibitor",0.243,0.897066127085198,0.946713880873679,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995101540024098 +"bacterial 50S ribosomal subunit inhibitor",0.235,0.95884172549251,0.851644962674686,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101 +"DNA polymerase inhibitor",0.229666666666667,1.15197130119976,0.222608692235743,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.443410599485832 +"AKT inhibitor",0.22725,1.15322930976848,0.22437644793259,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.443410599485832 +"protein synthesis inhibitor",0.210083333333333,0.935316714306232,0.90728584620874,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101 +"cyclooxygenase inhibitor",0.193833333333333,0.837323748980083,0.989425338225455,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995101540024098 +"HSP inhibitor",0.17025,1.21147229173282,0.0937937724513926,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.261017984411138 +"dopamine receptor antagonist",0.1645,1.01882994387948,0.767483539159279,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101 +"bromodomain inhibitor",0.163666666666667,1.34796947182408,0.0104162808386764,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.0540344568506337 +"potassium channel blocker",0.1605,1.21880429482789,0.0587742306504205,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H2126",0.187625428614804 +"HCV inhibitor",0.158916666666667,1.11659192988253,0.386980173562551,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.642690382060762 +"histamine receptor antagonist",0.136083333333333,0.979566180263055,0.855720482560209,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101 +"serotonin receptor agonist",0.133,1.71516795419898,2.90588505535249e-05,"H1650, H1975, H1648, H2126, H520, H1299, HCC44, A549, H1703, HCC15",10,4,"H1650, H1975, H2126, HCC44",0.000803961531980855 +"tyrosine kinase inhibitor",0.126833333333333,0.894017676592922,0.97026185028203,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995101540024098 +"bacterial DNA gyrase inhibitor",0.12475,1.29372078798817,0.0407587584228695,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.139569248430214 +"glutamate receptor antagonist",0.115333333333333,0.977015988827328,0.856698747435749,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101 +"microtubule inhibitor",0.113083333333333,1.13815380477918,0.327576205805222,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.578485640039008 +"DNA methyltransferase inhibitor",0.0930833333333334,1.1808025359,0.192432797310796,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.43167357234584 +"progesterone receptor agonist",0.0768333333333334,1.00142224618365,0.794727251766373,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101 +"estrogen receptor antagonist",0.0765,1.51789312715176,0.00181298275223466,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1648, HCC44, H1703",0.0188096960544346 +"phosphodiesterase inhibitor",0.0733333333333333,1.08045851658479,0.526231556470045,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.766267003280943 +"adrenergic receptor agonist",0.0403333333333333,1.11064971430185,0.452472905326071,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.71196056736095 +"sterol demethylase inhibitor",0.0378333333333332,1.42738201762612,0.00222006383011884,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0204739219888738 +"CC chemokine receptor antagonist",0.03075,1.15781056112585,0.30572681858952,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.563896132065115 +"AP inhibitor",0.01375,1.10037845762265,0.454625422531691,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.71196056736095 +"growth factor receptor inhibitor",-0.0294166666666667,1.20072897996731,0.189910624691489,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.43167357234584 +"androgen receptor antagonist",-0.0505833333333333,1.32105209162541,0.0250627317145587,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.104010336615418 +"glucocorticoid receptor agonist",-0.0795,1.10852641744878,0.286352904065215,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1975",0.552727698544485 +"tubulin polymerization inhibitor",-0.0880833333333334,1.35971463973701,0.00696500206454767,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.0412925122398183 +"BCL inhibitor",-0.110916666666667,0.97000397921708,0.876326884665977,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101 +"JAK inhibitor",-0.120583333333333,0.938358378749663,0.922335846036889,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101 +"Aurora kinase inhibitor",-0.12675,1.15973164019644,0.201954317472493,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.441110746058341 +"MEK inhibitor",-0.12775,1.52971085354538,0.000602854834447704,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H520, H1299, HCC44",0.00833949187652658 +"adrenergic receptor antagonist",-0.154666666666667,0.82305300098125,0.995101540024098,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995101540024098 +"adenosine receptor antagonist",-0.161583333333333,1.38589553970337,0.0383476448878849,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, H1299",0.138384979378019 +"Bcr.Abl kinase inhibitor",-0.185333333333333,1.17267994031801,0.216024891854153,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.443410599485832 +"Abl kinase inhibitor",-0.194666666666667,1.05996452199061,0.553529871258227,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.792120333007463 +"antioxidant",-0.205166666666667,1.18668268205059,0.15175071691499,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.37045027952777 +"HDAC inhibitor",-0.2235,1.10553166970796,0.3602338127518,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.622904301216653 +"ribonucleotide reductase inhibitor",-0.230083333333333,1.40655701227781,0.00270008486262209,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1648, H1299, H1703",0.0214204138494854 +"retinoid receptor agonist",-0.246166666666667,1.07782321314206,0.430192750540294,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.700117613624399 +"CDK inhibitor",-0.25725,1.27355387686298,0.0340165253075869,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.134446266691891 +"acetylcholine receptor antagonist",-0.258833333333333,1.41661143920871,0.00087757273138874,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, H460",0.0104055052436093 +"DNA inhibitor",-0.28025,0.875908580223468,0.962925550187264,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995101540024098 +"DNA synthesis inhibitor",-0.287166666666667,1.03828764917254,0.589188937900493,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.828859014334592 +"MET inhibitor",-0.299833333333333,1.2458488039984,0.617762537095821,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC95, H1975",0.854571509649219 +"protein tyrosine kinase inhibitor",-0.322166666666667,1.1781454481386,0.105702599679342,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.265858053738951 +"topoisomerase inhibitor",-0.33525,1.43605198215613,0.000157945690400697,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1648, H1299, H1703",0.00314867287279141 +"PLK inhibitor",-0.3605,1.80454040988532,0.000189679088722374,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,7,"H1650, H1648, H2126, H520, H460, H1299, H1703",0.00314867287279141 +"MDM inhibitor",-0.389583333333333,1.52233704656142,2.74910526086175e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H520, A549",0.000803961531980855 +"src inhibitor",-0.397583333333333,0.927751579047022,0.787468623596433,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101 +"DNA alkylating agent",-0.40425,0.888010557369674,0.825690852330219,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101 +"PI3K inhibitor",-0.44475,0.842401558856366,0.905941820867927,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101 +"EGFR inhibitor",-0.480416666666667,1.22737980032361,0.0127257599189964,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0586798929598168 +"vitamin D receptor agonist",-0.520166666666667,1.25996001620061,0.011320851593563,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0552723930744548 +"estrogen receptor agonist",-0.546416666666667,0.951931095513778,0.46501032655729,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.714738094523242 +"CHK inhibitor",-0.58625,1.14392022329913,0.0420389302500645,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.139569248430214 +"thymidylate synthase inhibitor",-0.607416666666667,0.900989401444408,0.500947081242813,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.742475138270598 +"mTOR inhibitor",-0.6845,0.988909362516468,0.0943438497871585,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1975, A549",0.261017984411138 diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_results.csv b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_results.csv new file mode 100644 index 0000000..022f2b5 --- /dev/null +++ b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_results.csv @@ -0,0 +1,995 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"H1650","Pearson.est","EGFR inhibitor",-0.69499,-1.87,0.0124,1196,0.547,"ARRY.334543, BIBU.1361, AST.1306, WZ.4002, CNX.2006, WZ.3146, TAK.285, gefitinib, GW.583340, XL.647, neratinib, PD.168393, WZ8040, vandetanib, PD.153035, lapatinib, BMS.690514, AZD8931, AEE788, BMS.599626, pelitinib, dacomitinib, canertinib, osimertinib, afatinib, poziotinib, erlotinib, icotinib",1.90657831483776,0.262012673666569,FALSE +"H1650","Pearson.est","Abl kinase inhibitor",0.34763,0.875,0.588,519,0.814,"tozasertib, KW.2449, flumatinib, bafetinib, GZD824, imatinib",0.230622673923862,0.0893755951107988,FALSE +"H1650","Pearson.est","acetylcholine receptor agonist",0.7087,1.73,0.0188,399,0.157,"xanomeline, oxiracetam, nefiracetam, tremorine, pilocarpine",1.72584215073632,0.804100347590766,TRUE +"H1650","Pearson.est","acetylcholine receptor antagonist",-0.6503,-1.74,0.0312,1235,0.401,"iododexetimide, darifenacin",1.50584540598156,0.396855627379818,FALSE +"H1650","Pearson.est","adenosine receptor antagonist",-0.5796,-1.52,0.105,1335,0.454,"MRS.1220, CGS.15943",0.978810700930062,0.342944147142896,FALSE +"H1650","Pearson.est","adrenergic receptor agonist",-0.3338,-0.877,0.579,1109,0.715,"A61603, isoxsuprine, methyldopa, ritodrine, xylazine, isoetharine",0.237321436272564,0.145693958198919,FALSE +"H1650","Pearson.est","adrenergic receptor antagonist",-0.23368,-0.648,0.881,1277,0.924,"metoprolol, prazosin, practolol",0.0550240915879521,0.0343280287798933,FALSE +"H1650","Pearson.est","AKT inhibitor",0.40596,1.02,0.416,100,0.676,"uprosertib, GDC.0068",0.380906669373257,0.170053304058364,FALSE +"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.40275,-1.11,0.313,1301,0.782,"lorlatinib, AZD3463, AP26113",0.504455662453552,0.106793246940152,FALSE +"H1650","Pearson.est","androgen receptor antagonist",-0.60305,-1.6,0.0876,1174,0.467,"bicalutamide, enzalutamide, RU.58841, flutamide",1.05749589383192,0.330683119433888,FALSE +"H1650","Pearson.est","antioxidant",-0.51703,-1.39,0.12,1434,0.558,"rutin",0.920818753952375,0.253365801062421,FALSE +"H1650","Pearson.est","AP inhibitor",-0.38175,-0.988,0.446,1309,0.78,"tanshinone.i, birinapant",0.350665141287858,0.10790539730952,FALSE +"H1650","Pearson.est","ATPase inhibitor",0.55822,1.39,0.114,245,0.522,"k.strophanthidin, evodiamine, ouabain, digitoxin, NMS.873",0.943095148663527,0.282329496997738,FALSE +"H1650","Pearson.est","Aurora kinase inhibitor",0.68046,1.72,0.0185,385,0.126,"PHA.680632, danusertib, AMG900, barasertib, CCT137690, tozasertib, MK.8745, SNS.314, GSK1070916, barasertib.HQPA, MK.5108, KW.2449, alisertib, AT.9283, CCT129202, hesperadin, PF.03814735, ENMD.2076",1.73282827159699,0.899629454882437,TRUE +"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.31141,0.783,0.73,353,0.897,"valnemulin, azithromycin, tilmicosin",0.136677139879544,0.0472075569559079,FALSE +"H1650","Pearson.est","bacterial DNA gyrase inhibitor",-0.40901,-1.05,0.393,1300,0.73,"sarafloxacin, lomefloxacin",0.405607449624573,0.136677139879544,FALSE +"H1650","Pearson.est","BCL inhibitor",0.48413,1.24,0.213,304,0.6,"venetoclax, navitoclax, gossypol",0.671620396561262,0.221848749616356,FALSE +"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.3598,0.892,0.566,519,0.807,"tozasertib, flumatinib, bafetinib, GZD824, imatinib",0.247183568811729,0.0931264652779296,FALSE +"H1650","Pearson.est","benzodiazepine receptor agonist",0.28805,0.73,0.791,150,0.864,"ZK.93423, nefiracetam",0.101823516502323,0.0634862575211067,FALSE +"H1650","Pearson.est","bromodomain inhibitor",0.7214,1.81,0.0146,319,0.136,"I.BET.762, bromosporine, JQ1...., I.BET151, PFI.1",1.83564714421556,0.866461091629782,TRUE +"H1650","Pearson.est","calcium channel blocker",-0.34088,-0.921,0.505,1296,0.744,"SR.33805, tetrandrine, mibefradil",0.296708621881339,0.128427064454121,FALSE +"H1650","Pearson.est","CC chemokine receptor antagonist",-0.36072,-0.93,0.51,1106,0.758,"MK.0812, RS.504393, navarixin, ZK811752",0.292429823902064,0.120330794367946,FALSE +"H1650","Pearson.est","CDK inhibitor",0.56939,1.41,0.121,247,0.523,"indisulam, PHA.793887, JNJ.7706621, alvocidib, PHA.848125, AT.7519, ribociclib, R547, dinaciclib, aminopurvalanol.a, palbociclib, abemaciclib",0.91721462968355,0.281498311132726,FALSE +"H1650","Pearson.est","CHK inhibitor",-0.53348,-1.44,0.115,984,0.532,"LY2603618, LY2606368, SCH.900776, AZD7762, CHIR.124",0.939302159646388,0.274088367704952,FALSE +"H1650","Pearson.est","cyclooxygenase inhibitor",-0.33401,-0.889,0.559,1373,0.72,"metoxibutropate, FR.122047, FK.3311, naproxen",0.252588192113577,0.142667503568732,FALSE +"H1650","Pearson.est","cytochrome P450 inhibitor",-0.40919,-1.12,0.319,1261,0.815,"clotrimazole, metyrapone",0.496209316942819,0.0888423912600234,FALSE +"H1650","Pearson.est","DNA alkylating agent",0.48766,1.23,0.218,376,0.586,"estramustine, carmustine, mitomycin.c, carboplatin, satraplatin, melphalan",0.661543506395395,0.232102383981909,FALSE +"H1650","Pearson.est","DNA inhibitor",0.405,1.03,0.423,424,0.683,"carmustine, oxaliplatin, chlorambucil, carboplatin, pibenzimol, bendamustine, melphalan, mechlorethamine, valrubicin",0.373659632624958,0.165579296318467,FALSE +"H1650","Pearson.est","DNA methyltransferase inhibitor",0.62668,1.61,0.0335,329,0.217,"decitabine, disulfiram, SGI.1027, fdcyd",1.47495519296315,0.66354026615147,TRUE +"H1650","Pearson.est","DNA polymerase inhibitor",-0.30496,-0.823,0.633,1271,0.753,"cidofovir, menadione",0.198596289982645,0.123205023799299,FALSE +"H1650","Pearson.est","DNA synthesis inhibitor",-0.35013,-0.954,0.483,1167,0.745,"enocitabine, artemisinin, CB.10.277, estramustine.phosphate",0.316052869248488,0.127843727251707,FALSE +"H1650","Pearson.est","dopamine receptor antagonist",-0.33122,-0.894,0.545,1284,0.737,"nemonapride, clebopride, piperacetazine, remoxipride",0.263603497723358,0.132532512140949,FALSE +"H1650","Pearson.est","estrogen receptor agonist",-0.4736,-1.23,0.192,1159,0.695,"levonorgestrel, estradiol, estradiol.cypionate",0.71669877129645,0.158015195409886,FALSE +"H1650","Pearson.est","estrogen receptor antagonist",-0.50094,-1.35,0.143,890,0.567,"toremifene, danazol, clomifene, raloxifene, fulvestrant",0.844663962534938,0.246416941107093,FALSE +"H1650","Pearson.est","FGFR inhibitor",0.31472,0.788,0.742,324,0.914,"dovitinib, regorafenib, nintedanib",0.129596094720973,0.0390538042661686,FALSE +"H1650","Pearson.est","FLT3 inhibitor",0.44308,1.11,0.345,439,0.637,"sorafenib, dovitinib, tozasertib, TG.101348, KW.2449, tandutinib, tyrphostin.AG.1296, ENMD.2076, sunitinib",0.462180904926726,0.19586056766465,FALSE +"H1650","Pearson.est","glucocorticoid receptor agonist",0.27445,0.694,0.812,168,0.889,"hydrocortisone, prednisolone.hemisuccinate, fluorometholone, fluticasone.propionate, beclomethasone.dipropionate",0.0904439707588247,0.0510982390297863,FALSE +"H1650","Pearson.est","glutamate receptor antagonist",-0.42851,-1.16,0.241,1371,0.781,"MTPG, SIB.1757, CGP.37849",0.617982957425132,0.1073489661227,FALSE +"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.36414,0.92,0.547,924,0.834,"CHIR.99021, kenpaullone, AZD2858, indirubin, TWS.119, GSK.3.inhibitor.IX, CHIR.98014, tideglusib, LY2090314",0.262012673666569,0.0788339493622613,FALSE +"H1650","Pearson.est","growth factor receptor inhibitor",0.49613,1.27,0.201,210,0.614,"danusertib, PHA.848125, GSK1838705A",0.696803942579511,0.211831628858832,FALSE +"H1650","Pearson.est","HCV inhibitor",-0.36027,-0.976,0.448,1427,0.768,"PSI.7976",0.348721986001856,0.114638779968488,FALSE +"H1650","Pearson.est","HDAC inhibitor",-0.19221,-0.511,0.98,1345,0.976,"mocetinostat, romidepsin, JNJ.26481585",0.00877392430750515,0.0105501823333082,FALSE +"H1650","Pearson.est","histamine receptor antagonist",-0.39816,-1.08,0.36,1084,0.712,"nizatidine, ranitidine, cimetidine, lafutidine, BF2.649, tecastemizole, famotidine, astemizole, chloropyramine",0.443697499232713,0.147520006363144,FALSE +"H1650","Pearson.est","HMGCR inhibitor",-0.58846,-1.59,0.0576,1099,0.407,"lovastatin, simvastatin, fluvastatin, pitavastatin",1.23957751657679,0.39040559077478,FALSE +"H1650","Pearson.est","HSP inhibitor",0.5087,1.28,0.174,432,0.682,"SNX.2112, NVP.AUY922, ganetespib, XL888, tanespimycin, SNX.5422, BIIB021, NMS.E973, PU.H71, alvespimycin",0.7594507517174,0.166215625343521,FALSE +"H1650","Pearson.est","JAK inhibitor",0.30266,0.771,0.717,291,0.892,"AZD1480, tozasertib, TG.101348, AZ960, AT.9283",0.1444808443322,0.0496351456238769,FALSE +"H1650","Pearson.est","KIT inhibitor",0.37336,0.917,0.542,463,0.812,"sorafenib, OSI.930, KI.8751, tandutinib, regorafenib, cediranib, sunitinib, masitinib",0.266000713461613,0.0904439707588247,FALSE +"H1650","Pearson.est","MDM inhibitor",-0.37143,-0.968,0.449,1316,0.75,"serdemetan, RITA",0.347753658996677,0.1249387366083,FALSE +"H1650","Pearson.est","MEK inhibitor",0.44378,1.11,0.339,248,0.637,"PD.0325901, cobimetinib, refametinib, trametinib, Ro.4987655, AS.703026",0.469800301796918,0.19586056766465,FALSE +"H1650","Pearson.est","MET inhibitor",-0.39804,-1.08,0.334,1424,0.712,"PF.04217903",0.476253533188435,0.147520006363144,FALSE +"H1650","Pearson.est","microtubule inhibitor",0.488,1.24,0.219,126,0.6,"vinflunine, D.64131, cabazitaxel, vinblastine",0.659555885159882,0.221848749616356,FALSE +"H1650","Pearson.est","mTOR inhibitor",-0.48457,-1.27,0.201,1165,0.67,"everolimus, temsirolimus, LY3023414, PKI.179, torin.2, PF.05212384, GSK2126458, PI.103, WAY.600, deforolimus, SB.2343, sirolimus",0.696803942579511,0.173925197299174,FALSE +"H1650","Pearson.est","NFkB pathway inhibitor",0.31241,0.77,0.732,420,0.87,"bortezomib, parthenolide, curcumin, parthenolide...., EVP4593, BAY.11.7082",0.135488918941608,0.0604807473813815,FALSE +"H1650","Pearson.est","opioid receptor agonist",0.44695,1.1,0.346,474,0.63,"trimebutine, salvinorin.a, spiradoline, ADL5859",0.460923901207223,0.200659450546418,FALSE +"H1650","Pearson.est","p38 MAPK inhibitor",0.49107,1.22,0.24,91,0.574,"skepinone.l, talmapimod",0.619788758288394,0.241088107602027,FALSE +"H1650","Pearson.est","PARP inhibitor",0.7127,1.81,0.0153,282,0.136,"niraparib, talazoparib, olaparib, PJ.34, endo.IWR.1",1.8153085691824,0.866461091629782,TRUE +"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.4571,1.14,0.316,463,0.633,"sorafenib, axitinib, crenolanib, dovitinib, KI.8751, CP.673451, tandutinib, regorafenib, nintedanib, trapidil, sunitinib, SU014813, masitinib",0.500312917381596,0.198596289982645,FALSE +"H1650","Pearson.est","phosphatase inhibitor",-0.37351,-1,0.423,1244,0.795,"BVT.948, menadione, mycophenolate.mofetil, bis.maltolato.oxovanadium.IV.",0.373659632624958,0.0996328713435297,FALSE +"H1650","Pearson.est","phosphodiesterase inhibitor",-0.27408,-0.725,0.791,1200,0.879,"cilostamide, GSK256066, EMD.53998",0.101823516502323,0.0560111249262281,FALSE +"H1650","Pearson.est","PI3K inhibitor",-0.25728,-0.685,0.826,1195,0.906,"LY3023414, PI3K.IN.2, PKI.179, idelalisib, PF.05212384, GSK2126458, PI.103, SB.2343",0.0830199526796178,0.0428718023231869,FALSE +"H1650","Pearson.est","PLK inhibitor",0.9121,2.33,0,85,0,"GW.843682X, volasertib, NMS.1286937, rigosertib, HMN.214, BI.2536",Inf,Inf,TRUE +"H1650","Pearson.est","potassium channel blocker",-0.30929,-0.836,0.613,1430,0.758,"ibutilide",0.212539525481585,0.120330794367946,FALSE +"H1650","Pearson.est","PPAR receptor agonist",-0.66674,-1.77,0.0224,1291,0.5,"S26948, clofibrate, fenofibrate, GW.501516",1.64975198166584,0.301029995663981,FALSE +"H1650","Pearson.est","progesterone receptor agonist",-0.22784,-0.605,0.899,1159,0.943,"levonorgestrel, norethindrone.acetate",0.0462403082667712,0.0254883072626717,FALSE +"H1650","Pearson.est","proteasome inhibitor",0.51224,1.29,0.191,405,0.714,"bortezomib, ixazomib, carfilzomib, MG.132",0.718966632752272,0.146301788223826,FALSE +"H1650","Pearson.est","protein synthesis inhibitor",0.41741,1.05,0.389,292,0.672,"harringtonine, tedizolid.phosphate, anguidine, cycloheximide, bruceantin, homoharringtonine, puromycin",0.410050398674292,0.172630726946175,FALSE +"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.35833,0.908,0.566,16,0.803,"PP.121",0.247183568811729,0.095284454721319,FALSE +"H1650","Pearson.est","RAF inhibitor",0.46645,1.15,0.273,554,0.644,"sorafenib, SB.590885, dabrafenib, regorafenib, TAK.632, GDC.0879, AZ.628, vemurafenib",0.563837352959244,0.191114132640188,FALSE +"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.42025,1.05,0.393,290,0.672,"sorafenib, cabozantinib, regorafenib",0.405607449624573,0.172630726946175,FALSE +"H1650","Pearson.est","retinoid receptor agonist",0.19188,0.485,0.989,223,1,"tamibarotene",0.0048037084028206,0,FALSE +"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.33652,0.844,0.659,363,0.845,"cytarabine, pentostatin, cladribine, fludarabine",0.18111458540599,0.0731432910503077,FALSE +"H1650","Pearson.est","serotonin receptor agonist",0.73148,1.84,0.00969,93,0.215,"aripiprazole, pardoprunox, zolmitriptan",2.01367622294923,0.667561540084395,TRUE +"H1650","Pearson.est","serotonin receptor antagonist",0.6872,1.72,0.0294,386,0.126,"aripiprazole, SB.200646, paliperidone, lurasidone, pirenperone, SB.216641, ziprasidone, sertindole",1.53165266958784,0.899629454882437,TRUE +"H1650","Pearson.est","sodium channel blocker",0.2338,0.593,0.931,429,0.969,"brivaracetam, mexiletine, benzocaine, mepivacaine",0.0310503190186574,0.0136762229492347,FALSE +"H1650","Pearson.est","src inhibitor",-0.34202,-0.898,0.556,1051,0.757,"bosutinib, PP.2, ZM.306416, dasatinib, saracatinib, PP.1",0.254925208417942,0.120904120499927,FALSE +"H1650","Pearson.est","sterol demethylase inhibitor",0.19198,0.481,0.978,475,0.985,"chlormidazole, lanoconazole",0.00966114521239857,0.00656376950238827,FALSE +"H1650","Pearson.est","TGF beta receptor inhibitor",-0.40915,-1.1,0.337,590,0.755,"SB.431542, LY2109761, repsox, SB.525334, adaprev, D.4476",0.472370099128661,0.122053048370812,FALSE +"H1650","Pearson.est","thymidylate synthase inhibitor",0.48768,1.2,0.263,579,0.579,"carmofur, trifluridine, capecitabine, raltitrexed",0.580044251510242,0.237321436272564,FALSE +"H1650","Pearson.est","topoisomerase inhibitor",0.51288,1.27,0.202,359,0.614,"topotecan, nemorubicin, dexrazoxane, SN.38, daunorubicin, etoposide.phosphate, idarubicin, TAS.103, exatecan.mesylate, amsacrine, rubitecan, genz.644282, amonafide",0.694648630553376,0.211831628858832,FALSE +"H1650","Pearson.est","tubulin polymerization inhibitor",0.7108,1.77,0.0237,321,0.146,"docetaxel, verubulin, vindesine, fosbretabulin, paclitaxel, fenbendazole, KX2.391, epothilone.b, taltobulin, albendazole, BNC105, dolastatin.10, oxibendazole, vinblastine, plinabulin, ABT.751, vincristine, CYT.997, combretastatin.A.4, parbendazole, indibulin",1.6252516539899,0.835647144215563,TRUE +"H1650","Pearson.est","tyrosine kinase inhibitor",0.30262,0.755,0.749,25,0.87,"sorafenib, PP.121, tivantinib",0.125518182300534,0.0604807473813815,FALSE +"H1650","Pearson.est","VEGFR inhibitor",0.29552,0.737,0.771,447,0.875,"sorafenib, OSI.930, axitinib, dovitinib, KI.8751, semaxanib, cabozantinib, regorafenib, nintedanib, cediranib, tivozanib, ENMD.2076, sunitinib, golvatinib, SU014813",0.112945621949043,0.0579919469776868,FALSE +"H1650","Pearson.est","vitamin D receptor agonist",-0.64135,-1.72,0.0354,1225,0.333,"calcitriol, paricalcitol",1.45099673797421,0.47755576649368,FALSE +"HCC95","Pearson.est","EGFR inhibitor",-0.7411,-1.89,0.00798,1158,0.433,"PD.168393, FERb.033, salvianolic.acid.B, brigatinib, ARRY.334543, WZ.4002, pelitinib, BIBX.1382, AEE788, rociletinib, BIBU.1361, BMS.599626, poziotinib, WZ8040, icotinib, WZ.3146, BMS.690514, AZD8931, CNX.2006, erlotinib, dacomitinib, neratinib, osimertinib, canertinib, CUDC.101, afatinib, tucatinib, gefitinib, XL.647, CP.724714, lapatinib",2.09799710864927,0.363512103646635,FALSE +"HCC95","Pearson.est","Abl kinase inhibitor",0.27185,0.672,0.864,102,0.935,"KW.2449, GZD824",0.0634862575211067,0.0291883891274822,FALSE +"HCC95","Pearson.est","acetylcholine receptor agonist",0.63397,1.56,0.0514,395,0.432,"tremorine, xanomeline, nefiracetam, oxiracetam",1.28903688100472,0.364516253185088,FALSE +"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.42401,-1.11,0.322,1327,0.718,"dicycloverine, diphemanil",0.492144128304169,0.1438755557577,FALSE +"HCC95","Pearson.est","adenosine receptor antagonist",-0.49374,-1.28,0.205,1367,0.989,"PSB.1115, CGS.15943",0.688246138944246,0.0048037084028206,FALSE +"HCC95","Pearson.est","adrenergic receptor agonist",0.29311,0.723,0.78,167,0.991,"isoxsuprine, xylazine, ritodrine",0.10790539730952,0.00392634551472468,FALSE +"HCC95","Pearson.est","adrenergic receptor antagonist",-0.26514,-0.705,0.83,1363,0.858,"dihydroergocristine, atenolol......, practolol",0.0809219076239261,0.0665127121512946,FALSE +"HCC95","Pearson.est","AKT inhibitor",-0.37794,-0.982,0.412,1061,0.678,"triciribine, GSK2110183, A.674563, AT7867, GDC.0068, uprosertib",0.385102783966865,0.168770306132937,FALSE +"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.46196,-1.26,0.191,1027,0.925,"SB.505124, alectinib, NVP.TAE684, brigatinib, CEP.37440, AZD3463",0.718966632752272,0.0338582672609674,FALSE +"HCC95","Pearson.est","androgen receptor antagonist",0.42804,1.05,0.386,164,0.789,"flutamide",0.413412695328245,0.10292299679058,FALSE +"HCC95","Pearson.est","antioxidant",0.58078,1.45,0.0847,500,0.496,"benfotiamine, trolox, taurine, mesna, chlorogenic.acid",1.07211658966929,0.304518323509803,FALSE +"HCC95","Pearson.est","AP inhibitor",0.35959,0.859,0.616,24,0.954,"idronoxil",0.210419287835575,0.0204516252959049,FALSE +"HCC95","Pearson.est","ATPase inhibitor",0.27935,0.705,0.801,9,0.991,"k.strophanthidin",0.0963674839157623,0.00392634551472468,FALSE +"HCC95","Pearson.est","Aurora kinase inhibitor",0.2807,0.7,0.821,406,0.972,"KW.2449, ZM.447439, SNS.314, aurora.a.inhibitor.i, MK.5108, AMG900, AT.9283, PF.03814735, CYC116",0.0856568428805592,0.0123337350737254,FALSE +"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.4049,1.01,0.444,344,0.804,"tilmicosin, josamycin, dirithromycin",0.35261702988538,0.0947439512515487,FALSE +"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.5687,1.41,0.109,373,0.484,"nadifloxacin, finafloxacin, norfloxacin, trovafloxacin, sparfloxacin",0.962573502059376,0.315154638355588,FALSE +"HCC95","Pearson.est","BCL inhibitor",-0.27778,-0.729,0.786,1240,0.877,"venetoclax, obatoclax",0.104577453960592,0.0570004066339595,FALSE +"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.32214,-0.834,0.655,1246,0.763,"dasatinib, metatinib, imatinib",0.183758700008217,0.11747546204512,FALSE +"HCC95","Pearson.est","benzodiazepine receptor agonist",0.24587,0.608,0.916,172,0.936,"CGS.20625, indiplon",0.0381045263321496,0.0287241512618947,FALSE +"HCC95","Pearson.est","bromodomain inhibitor",0.5426,1.34,0.152,18,0.545,"PFI.1",0.818156412055227,0.263603497723358,FALSE +"HCC95","Pearson.est","calcium channel blocker",-0.39858,-1.08,0.354,1296,0.623,"mibefradil, tetrandrine, penfluridol",0.450996737974212,0.20551195334083,FALSE +"HCC95","Pearson.est","CC chemokine receptor antagonist",0.46241,1.13,0.32,143,0.687,"MK.0812, UNBS.5162",0.494850021680094,0.16304326294045,FALSE +"HCC95","Pearson.est","CDK inhibitor",-0.47113,-1.23,0.24,1067,0.81,"CR8..R., BMS.265246, aminopurvalanol.a, AZD5438, AT.7519, alvocidib, JNJ.7706621, PHA.793887, ribociclib, palbociclib, dinaciclib, arcyriaflavin.a, BMS.387032",0.619788758288394,0.0915149811213502,FALSE +"HCC95","Pearson.est","CHK inhibitor",-0.62405,-1.61,0.051,1089,0.688,"LY2603618, AZD7762, LY2606368, SCH.900776, PF.477736",1.29242982390206,0.162411561764489,FALSE +"HCC95","Pearson.est","cyclooxygenase inhibitor",0.45775,1.15,0.276,128,0.678,"AM.404, suxibuzone, ketoprofen, metoxibutropate, phenylbutazone, naproxen",0.559090917934782,0.168770306132937,FALSE +"HCC95","Pearson.est","cytochrome P450 inhibitor",0.74196,1.79,0.00984,178,0.188,"eplerenone, cobicistat, metyrapone",2.00700490156866,0.72584215073632,TRUE +"HCC95","Pearson.est","DNA alkylating agent",-0.40951,-1.09,0.334,1356,0.675,"mitomycin.c, dacarbazine",0.476253533188435,0.170696227168975,FALSE +"HCC95","Pearson.est","DNA inhibitor",-0.21899,-0.577,0.93,1443,0.943,"mechlorethamine",0.0315170514460649,0.0254883072626717,FALSE +"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.31133,-0.837,0.636,1093,0.814,"disulfiram, SGI.1027, azacitidine",0.196542884351586,0.0893755951107988,FALSE +"HCC95","Pearson.est","DNA polymerase inhibitor",-0.31115,-0.812,0.633,1379,0.775,"cidofovir",0.198596289982645,0.11069829749369,FALSE +"HCC95","Pearson.est","DNA synthesis inhibitor",0.35427,0.869,0.617,199,0.967,"nelarabine, artesunate, CB.10.277, estramustine.phosphate",0.209714835966758,0.0145735259169983,FALSE +"HCC95","Pearson.est","dopamine receptor antagonist",0.32475,0.806,0.712,253,0.966,"paliperidone, nemonapride, raclopride, clebopride",0.147520006363144,0.0150228735845067,FALSE +"HCC95","Pearson.est","estrogen receptor agonist",-0.41475,-1.11,0.341,1351,0.718,"equol, levonorgestrel",0.467245621007502,0.1438755557577,FALSE +"HCC95","Pearson.est","estrogen receptor antagonist",0.51015,1.26,0.202,261,0.593,"fulvestrant, raloxifene, toremifene, danazol",0.694648630553376,0.226945306635737,FALSE +"HCC95","Pearson.est","FGFR inhibitor",0.34086,0.847,0.633,4,0.919,"MK.2461",0.198596289982645,0.0366844886138887,FALSE +"HCC95","Pearson.est","FLT3 inhibitor",0.32962,0.805,0.685,52,0.94,"KW.2449, gilteritinib",0.164309428507574,0.0268721464003014,FALSE +"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.38943,-1.03,0.386,1087,0.62,"triamcinolone.acetonide, desonide, dexamethasone.acetate, betamethasone, halobetasol.propionate, fluorometholone, ciclesonide, beclomethasone.dipropionate, fluticasone.propionate, methylprednisolone, difluprednate, halcinonide, flumethasone.pivalate, prednisolone.acetate, flumethasone",0.413412695328245,0.207608310501746,FALSE +"HCC95","Pearson.est","glutamate receptor antagonist",0.25273,0.63,0.892,357,0.936,"JNJ.16259685, kynurenic.acid, LY456236, MTPG",0.0496351456238769,0.0287241512618947,FALSE +"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.51858,1.27,0.194,427,0.608,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, TWS.119",0.712198270069774,0.216096420727265,FALSE +"HCC95","Pearson.est","growth factor receptor inhibitor",-0.55716,-1.39,0.159,1203,0.806,"GW.441756, AZD3463",0.798602875679548,0.0936649581949093,FALSE +"HCC95","Pearson.est","HCV inhibitor",0.28362,0.691,0.845,85,0.935,"mericitabine",0.0731432910503077,0.0291883891274822,FALSE +"HCC95","Pearson.est","HDAC inhibitor",0.34106,0.852,0.614,397,0.938,"RGFP966, R306465, entinostat, RG2833, romidepsin, nexturastat.a, panobinostat, AR.42, mocetinostat, belinostat",0.211831628858832,0.0277971616209356,FALSE +"HCC95","Pearson.est","histamine receptor antagonist",0.36832,0.909,0.572,210,0.918,"ICI.162846, BF2.649, famotidine, epinastine, nizatidine",0.242603971206976,0.0371573187987575,FALSE +"HCC95","Pearson.est","HMGCR inhibitor",0.88203,2.18,0,176,0.0055,"mevastatin, lovastatin, pitavastatin, fluvastatin, atorvastatin, simvastatin",Inf,2.25963731050576,TRUE +"HCC95","Pearson.est","HSP inhibitor",0.70327,1.76,0.0118,240,0.177,"SNX.5422, BIIB021, ganetespib, XL888, tanespimycin, KW.2478, SNX.2112, NVP.AUY922",1.92811799269387,0.752026733638193,TRUE +"HCC95","Pearson.est","JAK inhibitor",-0.35474,-0.913,0.536,1162,0.772,"CEP.33779, filgotinib, atiprimod, ruxolitinib, pacritinib",0.27083521030723,0.112382699664264,FALSE +"HCC95","Pearson.est","KIT inhibitor",-0.40636,-1.1,0.32,1180,0.695,"pazopanib, tandutinib, dasatinib, sunitinib, lenvatinib, imatinib",0.494850021680094,0.158015195409886,FALSE +"HCC95","Pearson.est","MDM inhibitor",0.54328,1.34,0.173,348,0.545,"AMG.232, CGM097, serdemetan",0.761953896871205,0.263603497723358,FALSE +"HCC95","Pearson.est","MEK inhibitor",0.30242,0.75,0.748,254,0.979,"arctigenin, PD.184352, refametinib, nobiletin",0.126098402135539,0.00921730819686218,FALSE +"HCC95","Pearson.est","MET inhibitor",0.8132,2,0,237,0.0366,"NVP.BVU972, PHA.665752, AMG458, PF.04217903",Inf,1.43651891460559,TRUE +"HCC95","Pearson.est","microtubule inhibitor",0.37536,0.936,0.531,199,0.928,"cytochalasin.b, secnidazole, estramustine.phosphate",0.274905478918531,0.0324520237811379,FALSE +"HCC95","Pearson.est","mTOR inhibitor",-0.46661,-1.25,0.216,1066,0.846,"sirolimus, everolimus, MLN0128, PI.103, OSI.027, WAY.600, XL388, torin.1, PKI.179, PF.05212384, AZD8055, PP242, ku.0063794, WYE.354, GDC.0980, WYE.125132",0.665546248849069,0.0726296369609765,FALSE +"HCC95","Pearson.est","NFkB pathway inhibitor",0.6393,1.57,0.0575,300,0.489,"BAY.11.7085, parthenolide, BAY.11.7082, tyloxapol",1.24033215531037,0.31069114087638,FALSE +"HCC95","Pearson.est","opioid receptor agonist",0.62423,1.52,0.0657,385,0.457,"cebranopadol, trimebutine, spiradoline, BW.180C",1.18243463044022,0.34008379993015,FALSE +"HCC95","Pearson.est","p38 MAPK inhibitor",0.37627,0.924,0.534,309,0.919,"TAK.715, VX.702",0.272458742971444,0.0366844886138887,FALSE +"HCC95","Pearson.est","PARP inhibitor",0.57243,1.42,0.116,133,0.509,"AG.14361, AZD2461",0.935542010773082,0.293282217663241,FALSE +"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.22836,-0.589,0.928,1180,0.961,"pazopanib, tandutinib, dasatinib, sunitinib, lenvatinib, imatinib",0.0324520237811379,0.0172766123314547,FALSE +"HCC95","Pearson.est","phosphatase inhibitor",0.4852,1.2,0.248,200,0.643,"CID.5458317, BVT.948, bis.maltolato.oxovanadium.IV., GSK2830371",0.605548319173784,0.191789027075778,FALSE +"HCC95","Pearson.est","phosphodiesterase inhibitor",0.44521,1.12,0.312,405,0.675,"GSK256066, avanafil, EMD.53998, YM.976, zardaverine, anagrelide",0.505845405981557,0.170696227168975,FALSE +"HCC95","Pearson.est","PI3K inhibitor",-0.42951,-1.14,0.299,1247,0.815,"PKI.179, alpelisib, PF.05212384, CH5132799, BGT226, PI3K.IN.2, taselisib, GDC.0980, idelalisib",0.52432881167557,0.0888423912600234,FALSE +"HCC95","Pearson.est","PLK inhibitor",-0.34517,-0.897,0.571,1127,0.769,"GW.843682X, volasertib, NMS.1286937",0.243363891754152,0.114073660198569,FALSE +"HCC95","Pearson.est","potassium channel blocker",0.28284,0.695,0.809,235,0.954,"meglitinide, dofetilide",0.0920514783877277,0.0204516252959049,FALSE +"HCC95","Pearson.est","PPAR receptor agonist",0.48148,1.2,0.25,448,0.643,"S26948, ciprofibrate, clofibrate, fenofibrate, pterostilbene",0.602059991327962,0.191789027075778,FALSE +"HCC95","Pearson.est","progesterone receptor agonist",0.53383,1.32,0.175,261,0.545,"norethindrone, tanaproget, dienogest, norgestrel, danazol",0.756961951313706,0.263603497723358,FALSE +"HCC95","Pearson.est","proteasome inhibitor",-0.43393,-1.15,0.288,1294,0.857,"MG.132",0.540607512240769,0.0670191780768018,FALSE +"HCC95","Pearson.est","protein synthesis inhibitor",0.25974,0.649,0.863,287,0.939,"mercaptopurine, clindamycin.phosphate, azomycin..2.nitroimidazole., florfenicol, puromycin",0.0639892042847904,0.0273344077338891,FALSE +"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.61374,-1.59,0.0627,1314,0.56,"NVP.TAE226, BMS.599626, AV.412, CP.724714",1.20273245916928,0.2518119729938,FALSE +"HCC95","Pearson.est","RAF inhibitor",-0.38393,-1.03,0.409,1174,0.62,"TAK.632, GDC.0879, SB.590885, CEP.32496, AZ.628",0.388276691992658,0.207608310501746,FALSE +"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.32061,-0.834,0.626,462,0.763,"sorafenib, apatinib, cabozantinib, vandetanib, regorafenib, sunitinib",0.20342566678957,0.11747546204512,FALSE +"HCC95","Pearson.est","retinoid receptor agonist",-0.42629,-1.13,0.289,1114,0.777,"bexarotene, adarotene, adapalene, tamibarotene, CD.437",0.539102157243452,0.109578981199086,FALSE +"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.48064,1.18,0.269,301,0.652,"clofarabine, hydroxyurea, cytarabine, fludarabine, triapine",0.570247719997592,0.18575240426808,FALSE +"HCC95","Pearson.est","serotonin receptor antagonist",0.58863,1.45,0.104,96,0.496,"tropisetron, lerisetron, paliperidone",0.98296666070122,0.304518323509803,FALSE +"HCC95","Pearson.est","sodium channel blocker",0.1677,0.412,1,506,0.997,"oxcarbazepine, A.803467, mexiletine, mepivacaine, quinidine",0,0.00130484168834428,FALSE +"HCC95","Pearson.est","src inhibitor",-0.46175,-1.19,0.248,1046,0.832,"PP.2, ZM.306416, PP.1, dasatinib, saracatinib",0.605548319173784,0.0798766737092761,FALSE +"HCC95","Pearson.est","sterol demethylase inhibitor",0.40552,1.01,0.438,92,0.804,"sulconazole",0.3585258894959,0.0947439512515487,FALSE +"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.54459,-1.47,0.104,922,0.728,"SB.525334, repsox, LY2109761, adaprev, SB.431542",0.98296666070122,0.137868620686963,FALSE +"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.33159,-0.857,0.608,1320,0.808,"carmofur",0.216096420727265,0.0925886392254138,FALSE +"HCC95","Pearson.est","topoisomerase inhibitor",0.3217,0.78,0.717,518,0.957,"nemorubicin, etoposide, beta.lapachone, camptothecin, doxorubicin, valrubicin, fleroxacin, amonafide, etoposide.phosphate, daunorubicin, rubitecan, exatecan.mesylate, teniposide",0.1444808443322,0.0190880622231565,FALSE +"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.39824,-1.07,0.348,841,0.61,"KX2.391, vincristine, verubulin, combretastatin.A.4, BNC105, flubendazole, epothilone.d, dolastatin.10, epothilone.b, vinorelbine, oxibendazole, mebendazole, parbendazole, ABT.751, fosbretabulin, CYT.997, plinabulin, taltobulin, fenbendazole",0.458420756053419,0.214670164989233,FALSE +"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.40111,-1.08,0.349,1189,0.623,"tyrphostin.A9, dasatinib, sunitinib, NVP.TAE226, BMS.599626, tivantinib, AV.412, CP.724714",0.45717457304082,0.20551195334083,FALSE +"HCC95","Pearson.est","VEGFR inhibitor",-0.27007,-0.705,0.815,990,0.858,"axitinib, MGCD.265, telatinib, motesanib, PD.173074, ENMD.2076, linifanib, ZM.306416, foretinib, pazopanib, SAR131675, sunitinib, AEE788, lucitanib, lenvatinib, BMS.690514, XL.647",0.0888423912600234,0.0665127121512946,FALSE +"HCC95","Pearson.est","vitamin D receptor agonist",-0.66372,-1.74,0.0367,1202,0.54,"doxercalciferol, tacalcitol, maxacalcitol",1.43533393574791,0.267606240177031,FALSE +"H1975","Pearson.est","EGFR inhibitor",0.40412,1.06,0.369,302,0.71,"CUDC.101, neratinib, dovitinib, CP.724714, tucatinib, BMS.599626, ARRY.334543, brigatinib, lapatinib, WZ.4002, AZD8931, BMS.690514, salvianolic.acid.B, AEE788",0.43297363384094,0.148741651280925,FALSE +"H1975","Pearson.est","Abl kinase inhibitor",-0.57883,-1.45,0.0976,1074,0.943,"GZD824, tozasertib, flumatinib, bosutinib, KW.2449",1.01055018233331,0.0254883072626717,FALSE +"H1975","Pearson.est","acetylcholine receptor agonist",0.38301,1.02,0.402,284,0.683,"oxiracetam, xanomeline, pilocarpine",0.39577394691553,0.165579296318467,FALSE +"H1975","Pearson.est","acetylcholine receptor antagonist",-0.35965,-0.899,0.559,1192,0.744,"dicycloverine, iododexetimide",0.252588192113577,0.128427064454121,FALSE +"H1975","Pearson.est","adenosine receptor antagonist",-0.38681,-0.952,0.508,1432,0.697,"theophylline",0.294136287716081,0.156767221901991,FALSE +"H1975","Pearson.est","adrenergic receptor agonist",-0.37747,-0.953,0.483,1334,0.717,"epinephrine, A61603, norepinephrine, terbutaline",0.316052869248488,0.1444808443322,FALSE +"H1975","Pearson.est","adrenergic receptor antagonist",-0.2289,-0.571,0.934,1008,0.964,"naftidrofuryl, vincamine, idazoxan, carvedilol, atenolol...., propranolol, metoprolol",0.0296531237699066,0.0159229660971692,FALSE +"H1975","Pearson.est","AKT inhibitor",0.25261,0.669,0.873,1085,0.857,"A.674563, GDC.0068, GSK2110183, uprosertib, AZD5363, triciribine, AT7867, CCT128930, palomid.529, ONC201, MK.2206",0.0589857562944303,0.0670191780768018,FALSE +"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.3712,0.98,0.445,207,0.67,"crizotinib, brigatinib, SB.505124",0.351639989019068,0.173925197299174,FALSE +"H1975","Pearson.est","androgen receptor antagonist",0.32433,0.84,0.628,319,0.709,"RU.58841, enzalutamide, nilutamide",0.202040356262804,0.149353764816933,FALSE +"H1975","Pearson.est","antioxidant",-0.48918,-1.26,0.2,1075,0.642,"chlorogenic.acid, mesna, benfotiamine",0.698970004336019,0.192464971931147,FALSE +"H1975","Pearson.est","AP inhibitor",-0.34413,-0.857,0.61,1349,0.731,"LCL.161",0.214670164989233,0.13608262304214,FALSE +"H1975","Pearson.est","ATPase inhibitor",0.56797,1.5,0.0943,210,0.558,"k.strophanthidin, digoxin, thonzonium",1.02548830726267,0.253365801062421,FALSE +"H1975","Pearson.est","Aurora kinase inhibitor",-0.50893,-1.26,0.212,1064,0.642,"SNS.314, tozasertib, ZM.447439, AMG900, TAK.901, AT.9283, PF.03814735, MK.8745, MLN.8054, MK.5108, GSK1070916, alisertib, CYC116, KW.2449",0.673664139071249,0.192464971931147,FALSE +"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.26186,0.672,0.831,299,0.877,"radezolid, azithromycin",0.080398976215889,0.0570004066339595,FALSE +"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.56566,-1.45,0.105,1172,0.943,"sarafloxacin, finafloxacin, trovafloxacin, sparfloxacin, novobiocin",0.978810700930062,0.0254883072626717,FALSE +"H1975","Pearson.est","BCL inhibitor",0.38889,1.02,0.415,888,0.683,"venetoclax, navitoclax, obatoclax, HA14.1, TW.37, oridonin, gossypol, ABT.737",0.381951903287907,0.165579296318467,FALSE +"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.53321,-1.35,0.156,946,0.87,"ponatinib, GZD824, tozasertib, flumatinib, bosutinib",0.806875401645538,0.0604807473813815,FALSE +"H1975","Pearson.est","benzodiazepine receptor agonist",0.33446,0.873,0.565,213,0.702,"eprinomectin, ZK.93423, piperazine",0.247951552180562,0.153662887870195,FALSE +"H1975","Pearson.est","bromodomain inhibitor",-0.47248,-1.18,0.294,1114,0.592,"PFI.1, bromosporine, OTX015",0.531652669587843,0.22767829327708,FALSE +"H1975","Pearson.est","calcium channel blocker",0.45927,1.19,0.261,314,0.669,"SKF.96365, efonidipine.monoethanolate, tetrandrine, SR.33805, cinnarazine",0.583359492661719,0.174573882232177,FALSE +"H1975","Pearson.est","CC chemokine receptor antagonist",-0.39557,-1,0.437,1106,0.755,"RS.504393, MK.0812, navarixin",0.359518563029578,0.122053048370812,FALSE +"H1975","Pearson.est","CDK inhibitor",0.53652,1.37,0.132,349,0.672,"R547, AT.7519, BMS.387032, indirubin, NU6027, CR8..R., indisulam, JNJ.7706621, P276.00, BMS.265246, TG.02, dinaciclib, AZD5438, PHA.848125",0.87942606879415,0.172630726946175,FALSE +"H1975","Pearson.est","CHK inhibitor",-0.42876,-1.1,0.338,1115,0.684,"AZD7762, LY2603618, LY2606368",0.471083299722345,0.164943898279884,FALSE +"H1975","Pearson.est","cyclooxygenase inhibitor",-0.43557,-1.09,0.344,1129,0.645,"curcumin, indoprofen, FK.3311, sulfasalazine, piroxicam, acetylsalicylsalicylic.acid, metoxibutropate",0.46344155742847,0.190440285364732,FALSE +"H1975","Pearson.est","cytochrome P450 inhibitor",-0.43563,-1.09,0.355,871,0.645,"itraconazole, eplerenone, clotrimazole, cobicistat",0.449771646944906,0.190440285364732,FALSE +"H1975","Pearson.est","DNA alkylating agent",-0.3039,-0.756,0.726,930,0.821,"melphalan, carboplatin, cisplatin, satraplatin, dianhydrogalactitol, TH.302, streptozotocin, cyclophosphamide",0.139063379299906,0.0856568428805592,FALSE +"H1975","Pearson.est","DNA inhibitor",0.32704,0.838,0.659,304,0.692,"busulfan, mechlorethamine, nimorazole, sangivamycin, bendamustine, metronidazole",0.18111458540599,0.159893905543242,FALSE +"H1975","Pearson.est","DNA methyltransferase inhibitor",-0.37289,-0.953,0.495,1276,0.717,"decitabine, RG108",0.305394801066431,0.1444808443322,FALSE +"H1975","Pearson.est","DNA polymerase inhibitor",-0.34784,-0.873,0.593,1425,0.725,"cephalomannine",0.226945306635737,0.139661993429006,FALSE +"H1975","Pearson.est","DNA synthesis inhibitor",-0.43626,-1.11,0.333,912,0.694,"artesunate, capecitabine, anisomycin, cisplatin, floxuridine, CB.10.277, estramustine.phosphate, altretamine",0.47755576649368,0.158640529545145,FALSE +"H1975","Pearson.est","dopamine receptor antagonist",-0.28285,-0.71,0.823,1263,0.864,"clebopride, UH.232...., isofloxythepin, amisulpride",0.0846001647877302,0.0634862575211067,FALSE +"H1975","Pearson.est","estrogen receptor agonist",-0.54129,-1.36,0.152,1182,0.955,"PPT, estradiol, estradiol.cypionate",0.818156412055227,0.0199966284162537,FALSE +"H1975","Pearson.est","estrogen receptor antagonist",-0.57199,-1.46,0.0968,1227,1,"raloxifene, toremifene, fulvestrant",1.01412464269161,0,FALSE +"H1975","Pearson.est","FGFR inhibitor",0.67314,1.83,0.0179,149,0.212,"erdafitinib, lenvatinib, dovitinib, regorafenib",1.74714696902011,0.673664139071249,TRUE +"H1975","Pearson.est","FLT3 inhibitor",0.35892,0.923,0.524,102,0.665,"sorafenib, TG.101348, dovitinib, ENMD.2076",0.280668713016273,0.177178354696895,FALSE +"H1975","Pearson.est","glucocorticoid receptor agonist",0.71508,1.89,0.00649,255,0.201,"hydrocortisone, dexamethasone.acetate, triamcinolone.acetonide, difluprednate, fludroxycortide, halcinonide, desonide, rimexolone, betamethasone, ciclesonide, deflazacort, prednisolone.hemisuccinate, methylprednisolone, flumethasone, fluocinolone.acetonide",2.18775530319963,0.696803942579511,TRUE +"H1975","Pearson.est","glutamate receptor antagonist",-0.39235,-0.989,0.473,1214,0.75,"JNJ.16259685, MTPG, LY456236, SIB.1757",0.325138859262188,0.1249387366083,FALSE +"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.36494,-0.912,0.571,1180,0.743,"LY2090314, AZD2858, tideglusib",0.243363891754152,0.129011186239425,FALSE +"H1975","Pearson.est","growth factor receptor inhibitor",0.37682,0.983,0.419,905,0.692,"PHA.848125, lestaurtinib, GSK1838705A, danusertib, GW.441756, GSK1904529A, AZD3463",0.377785977033705,0.159893905543242,FALSE +"H1975","Pearson.est","HCV inhibitor",0.43528,1.15,0.294,244,0.657,"narlaprevir, embelin, daclatasvir",0.531652669587843,0.182434630440219,FALSE +"H1975","Pearson.est","HDAC inhibitor",-0.382,-0.974,0.457,1004,0.726,"tacedinaline, givinostat, panobinostat, romidepsin, dacinostat, SB.939, M.344, entinostat, JNJ.26481585, RG2833, mocetinostat",0.34008379993015,0.139063379299906,FALSE +"H1975","Pearson.est","histamine receptor antagonist",-0.47536,-1.21,0.248,1105,0.566,"nizatidine, terfenadine, ebastine, lafutidine, cimetidine, pheniramine, tiotidine, BF2.649, chloropyramine",0.605548319173784,0.247183568811729,FALSE +"H1975","Pearson.est","HMGCR inhibitor",-0.526,-1.31,0.195,1077,0.732,"fluvastatin, mevastatin, simvastatin, pitavastatin",0.709965388637482,0.135488918941608,FALSE +"H1975","Pearson.est","HSP inhibitor",-0.50796,-1.29,0.178,1174,0.724,"VER.49009, ganetespib, BIIB021, NVP.AUY922, SNX.5422",0.749579997691106,0.140261433802853,FALSE +"H1975","Pearson.est","JAK inhibitor",0.44634,1.15,0.269,393,0.657,"AZD1480, TG.101348, AZ960, ruxolitinib, TG.101209, baricitinib, TG.02, lestaurtinib, atiprimod",0.570247719997592,0.182434630440219,FALSE +"H1975","Pearson.est","KIT inhibitor",0.35416,0.903,0.565,219,0.675,"sorafenib, lenvatinib, regorafenib, pazopanib, OSI.930",0.247951552180562,0.170696227168975,FALSE +"H1975","Pearson.est","MDM inhibitor",-0.47526,-1.22,0.247,1347,0.577,"RITA, serdemetan",0.607303046740334,0.238824186844269,FALSE +"H1975","Pearson.est","MEK inhibitor",-0.39755,-0.978,0.485,848,0.744,"AZD8330, PD.318088, Ro.4987655, arctigenin, selumetinib, TAK.733, PD.184352, refametinib, BIX.02188, nobiletin, PD.98059",0.314258261397736,0.128427064454121,FALSE +"H1975","Pearson.est","MET inhibitor",-0.78956,-1.99,0,1394,0.0987,"NVP.BVU972, INC.280, PF.04217903",Inf,1.00568284733036,TRUE +"H1975","Pearson.est","microtubule inhibitor",-0.49154,-1.24,0.224,794,0.571,"podophyllotoxin, cytochalasin.b, colchicine, D.64131, vinblastine, cabazitaxel, estramustine.phosphate",0.649751981665837,0.243363891754152,FALSE +"H1975","Pearson.est","mTOR inhibitor",0.69481,1.78,0.0186,264,0.212,"voxtalisib, AZD8055, AZD2014, PP242, OSI.027, torin.1, XL388, WYE.354, GSK2126458, PF.05212384, LY3023414, MLN0128, WAY.600, torin.2, ku.0063794, sirolimus, deforolimus",1.73048705578208,0.673664139071249,TRUE +"H1975","Pearson.est","NFkB pathway inhibitor",0.36622,0.967,0.444,143,0.666,"tyloxapol, EVP4593, betulinic.acid",0.35261702988538,0.176525770829699,FALSE +"H1975","Pearson.est","opioid receptor agonist",-0.35125,-0.897,0.578,1213,0.726,"cebranopadol, spiradoline",0.238072161579471,0.139063379299906,FALSE +"H1975","Pearson.est","p38 MAPK inhibitor",0.48132,1.25,0.21,138,0.602,"SB.242235, skepinone.l, talmapimod",0.677780705266081,0.220403508742175,FALSE +"H1975","Pearson.est","PARP inhibitor",-0.50183,-1.24,0.23,1112,0.571,"olaparib, talazoparib, E7449, niraparib",0.638272163982407,0.243363891754152,FALSE +"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.36497,0.929,0.528,179,0.68,"sorafenib, lenvatinib, dovitinib, regorafenib, pazopanib, crenolanib",0.277366077466188,0.167491087293764,FALSE +"H1975","Pearson.est","phosphatase inhibitor",-0.21472,-0.543,0.959,1342,0.959,"bis.maltolato.oxovanadium.IV.",0.0181813928293364,0.0181813928293364,FALSE +"H1975","Pearson.est","phosphodiesterase inhibitor",-0.40214,-1.01,0.445,1230,0.766,"zardaverine, EMD.53998, GSK256066, trequinsin",0.351639989019068,0.115771230367396,FALSE +"H1975","Pearson.est","PI3K inhibitor",0.51821,1.34,0.161,195,0.594,"voxtalisib, CH5132799, BGT226, alpelisib, GSK2126458, PF.05212384, LY3023414, PI3K.IN.2, CUDC.907",0.79317412396815,0.226213555018806,FALSE +"H1975","Pearson.est","PLK inhibitor",-0.35149,-0.879,0.604,1196,0.736,"GSK461364, BI.2536",0.218963061378868,0.133122185662501,FALSE +"H1975","Pearson.est","potassium channel blocker",0.32681,0.844,0.638,52,0.724,"ML133",0.195179321278838,0.140261433802853,FALSE +"H1975","Pearson.est","PPAR receptor agonist",-0.30873,-0.785,0.701,935,0.82,"oleoylethanolamide, pterostilbene, S26948, fenofibrate",0.154281982033341,0.0861861476162833,FALSE +"H1975","Pearson.est","progesterone receptor agonist",-0.26309,-0.656,0.876,984,0.907,"nomegestrol.acetate, dienogest, norethindrone.acetate",0.0574958938319193,0.0423927129399047,FALSE +"H1975","Pearson.est","proteasome inhibitor",-0.56693,-1.43,0.104,956,0.855,"ixazomib, carfilzomib, oprozomib, delanzomib, ixazomib.citrate, ONX.0914",0.98296666070122,0.0680338852718274,FALSE +"H1975","Pearson.est","protein synthesis inhibitor",0.43189,1.11,0.298,325,0.693,"clofoctol, bruceantin, tedizolid.phosphate, harringtonine, methacycline, chloramphenicol.palmitate, florfenicol, cycloheximide",0.525783735923745,0.159266765388193,FALSE +"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.41851,1.09,0.336,151,0.691,"mubritinib, CP.724714, BMS.599626",0.473660722610156,0.160521952625802,FALSE +"H1975","Pearson.est","RAF inhibitor",0.52285,1.34,0.153,232,0.594,"sorafenib, regorafenib, RAF265, SB.590885",0.815308569182401,0.226213555018806,FALSE +"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.6027,1.6,0.0662,230,0.44,"sorafenib, regorafenib, apatinib",1.1791420105603,0.356547323513813,FALSE +"H1975","Pearson.est","retinoid receptor agonist",0.37029,0.957,0.476,94,0.657,"adarotene, fenretinide",0.322393047279507,0.182434630440219,FALSE +"H1975","Pearson.est","ribonucleotide reductase inhibitor",-0.52269,-1.32,0.166,1181,0.778,"triapine, LY2334737, hydroxyurea, gemcitabine, cladribine, fludarabine, clofarabine",0.779891911959945,0.109020403010311,FALSE +"H1975","Pearson.est","serotonin receptor agonist",0.79385,2.12,0,190,0.0508,"NAN.190, aripiprazole, zolmitriptan, pardoprunox",Inf,1.29413628771608,TRUE +"H1975","Pearson.est","serotonin receptor antagonist",0.50867,1.37,0.161,113,0.672,"SB.200646, aripiprazole, ziprasidone, sertindole",0.79317412396815,0.172630726946175,FALSE +"H1975","Pearson.est","sodium channel blocker",-0.32072,-0.768,0.731,872,0.824,"butamben, benzethonium, oxcarbazepine, quinidine, mepivacaine, A.803467",0.13608262304214,0.0840727883028842,FALSE +"H1975","Pearson.est","src inhibitor",-0.50484,-1.26,0.211,1204,0.642,"masitinib, PP.2, bosutinib",0.675717544702307,0.192464971931147,FALSE +"H1975","Pearson.est","sterol demethylase inhibitor",0.39343,1,0.416,212,0.689,"posaconazole, sulconazole",0.380906669373257,0.161780778092374,FALSE +"H1975","Pearson.est","TGF beta receptor inhibitor",0.48772,1.29,0.205,146,0.577,"adaprev, SB.525334",0.688246138944246,0.238824186844269,FALSE +"H1975","Pearson.est","thymidylate synthase inhibitor",-0.48943,-1.24,0.237,1163,0.571,"raltitrexed, doxifluridine",0.625251653989896,0.243363891754152,FALSE +"H1975","Pearson.est","topoisomerase inhibitor",-0.60478,-1.53,0.0687,987,1,"epirubicin, camptothecin, idarubicin, etoposide.phosphate, valrubicin, mitoxantrone, amsacrine, TAS.103, amonafide, teniposide, voreloxin, daunorubicin, rubitecan, licochalcone.a, etoposide, irinotecan, genz.644282, exatecan.mesylate",1.16304326294045,0,FALSE +"H1975","Pearson.est","tubulin polymerization inhibitor",-0.54119,-1.34,0.149,1089,0.801,"albendazole, verubulin, fenbendazole, CYT.997, epothilone.b, paclitaxel, vinblastine, combretastatin.A.4, docetaxel, oxibendazole, parbendazole, nocodazole, epothilone.d, fosbretabulin, BNC105",0.826813731587726,0.0963674839157623,FALSE +"H1975","Pearson.est","tyrosine kinase inhibitor",0.29861,0.774,0.747,151,0.765,"sorafenib, mubritinib, CP.724714, regorafenib, BMS.599626",0.126679398184601,0.116338564846382,FALSE +"H1975","Pearson.est","VEGFR inhibitor",0.40632,1.05,0.365,302,0.694,"sorafenib, lenvatinib, dovitinib, ENMD.2076, regorafenib, pazopanib, RAF265, OSI.930, tivozanib, nintedanib, BMS.690514, AEE788",0.437707135543525,0.158640529545145,FALSE +"H1975","Pearson.est","vitamin D receptor agonist",0.48172,1.31,0.153,411,0.59,"maxacalcitol, tacalcitol, paricalcitol, alfacalcidol, ercalcitriol",0.815308569182401,0.229147988357856,FALSE +"H1648","Pearson.est","EGFR inhibitor",-0.72943,-1.96,0.013,1297,0.32,"tucatinib, vandetanib, AST.1306, lapatinib, OSI.420, CP.724714, neratinib, PD.153035, tyrphostin.AG.1478, BIBU.1361, XL.647, BMS.690514, poziotinib, BIBX.1382, osimertinib, AZD8931, afatinib, pelitinib, canertinib, dacomitinib, erlotinib, icotinib, gefitinib, WZ8040",1.88605664769316,0.494850021680094,FALSE +"H1648","Pearson.est","Abl kinase inhibitor",0.24575,0.622,0.912,640,0.963,"flumatinib, GZD824, nilotinib, bafetinib, metatinib, ponatinib, KW.2449, tozasertib",0.0400051616715838,0.0163737128754655,FALSE +"H1648","Pearson.est","acetylcholine receptor agonist",0.73411,1.87,0.0104,207,0.111,"tremorine, xanomeline, oxiracetam, pilocarpine",1.98296666070122,0.954677021213343,TRUE +"H1648","Pearson.est","acetylcholine receptor antagonist",-0.2362,-0.635,0.893,1121,0.972,"darifenacin, dicycloverine",0.0491485411114536,0.0123337350737254,FALSE +"H1648","Pearson.est","adenosine receptor antagonist",-0.41457,-1.11,0.32,1223,0.947,"PSB.1115, MRS.1220, CGS.15943",0.494850021680094,0.0236500209967266,FALSE +"H1648","Pearson.est","adrenergic receptor agonist",-0.55463,-1.54,0.0885,1108,1,"clenbuterol, metaraminol, A61603, oxymetazoline, isoetharine, terbutaline, lidamidine, methyldopa",1.05305672930217,0,FALSE +"H1648","Pearson.est","adrenergic receptor antagonist",-0.24037,-0.647,0.846,1281,0.989,"atenolol......, levobunolol, dronedarone",0.0726296369609765,0.0048037084028206,FALSE +"H1648","Pearson.est","AKT inhibitor",-0.4529,-1.21,0.23,1278,1,"CCT128930, uprosertib, triciribine",0.638272163982407,0,FALSE +"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.26153,-0.694,0.816,1413,0.96,"GW.788388",0.0883098412461389,0.0177287669604316,FALSE +"H1648","Pearson.est","androgen receptor antagonist",-0.55644,-1.52,0.0759,1164,1,"cyproterone.acetate, enzalutamide",1.11975822410452,0,FALSE +"H1648","Pearson.est","antioxidant",0.51334,1.28,0.181,77,0.646,"trolox",0.742321425130815,0.189767482004916,FALSE +"H1648","Pearson.est","AP inhibitor",0.61933,1.57,0.0598,4,0.369,"idronoxil",1.22329881601159,0.43297363384094,FALSE +"H1648","Pearson.est","ATPase inhibitor",0.50714,1.26,0.208,559,0.647,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, digitoxin, blebbistatin...., digoxin, digitoxigenin",0.681936665037238,0.1890957193313,FALSE +"H1648","Pearson.est","Aurora kinase inhibitor",0.3828,0.973,0.464,605,0.726,"AMG900, MK.5108, SNS.314, danusertib, CCT137690, barasertib, AT.9283, PHA.680632, hesperadin, ZM.447439, barasertib.HQPA, KW.2449, CYC116, alisertib, PF.03814735",0.333482019445119,0.139063379299906,FALSE +"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.33047,0.817,0.666,61,0.859,"valnemulin",0.176525770829699,0.0660068361687577,FALSE +"H1648","Pearson.est","bacterial DNA gyrase inhibitor",-0.34545,-0.93,0.515,1107,1,"sarafloxacin, finafloxacin, lomefloxacin, trovafloxacin",0.288192770958809,0,FALSE +"H1648","Pearson.est","BCL inhibitor",-0.26478,-0.711,0.781,1092,0.999,"oridonin, HA14.1, obatoclax, venetoclax",0.1073489661227,0.000434511774017692,FALSE +"H1648","Pearson.est","Bcr.Abl kinase inhibitor",0.30073,0.76,0.754,525,0.903,"flumatinib, GZD824, nilotinib, bafetinib, metatinib, ponatinib",0.122628654130226,0.0443122496864942,FALSE +"H1648","Pearson.est","benzodiazepine receptor agonist",0.28356,0.714,0.81,401,0.924,"ZK.93423, piperazine, indiplon, ivermectin",0.0915149811213502,0.0343280287798933,FALSE +"H1648","Pearson.est","bromodomain inhibitor",0.48759,1.24,0.223,208,0.579,"PFI.1, bromosporine",0.651695136951839,0.237321436272564,FALSE +"H1648","Pearson.est","calcium channel blocker",0.32458,0.807,0.695,7,0.852,"carboxyamidotriazole",0.158015195409886,0.0695604052332999,FALSE +"H1648","Pearson.est","CC chemokine receptor antagonist",0.43639,1.1,0.345,188,0.646,"UNBS.5162, MK.0812",0.462180904926726,0.189767482004916,FALSE +"H1648","Pearson.est","CDK inhibitor",-0.34114,-0.939,0.516,1234,1,"BMS.387032, alvocidib, arcyriaflavin.a, P276.00, AZD5438, TG.02, indirubin",0.287350298372789,0,FALSE +"H1648","Pearson.est","CHK inhibitor",-0.55234,-1.49,0.0797,1142,0.854,"LY2606368, CHIR.124, LY2603618, SCH.900776",1.09854167860389,0.068542129310995,FALSE +"H1648","Pearson.est","cyclooxygenase inhibitor",0.19843,0.504,0.972,534,0.977,"phenazone, sulfasalazine, AM.404, ketoprofen, tepoxalin, suxibuzone, acetylsalicylsalicylic.acid, piroxicam, metoxibutropate, ramifenazone, curcumin",0.0123337350737254,0.0101054362812269,FALSE +"H1648","Pearson.est","cytochrome P450 inhibitor",0.4913,1.24,0.23,178,0.579,"metyrapone, eplerenone",0.638272163982407,0.237321436272564,FALSE +"H1648","Pearson.est","DNA alkylating agent",-0.21508,-0.581,0.927,1104,0.994,"estramustine, ifosfamide, satraplatin, cisplatin, dacarbazine",0.0329202658555029,0.00261361560268669,FALSE +"H1648","Pearson.est","DNA inhibitor",0.37825,0.971,0.464,361,0.706,"teroxirone, valrubicin, tirapazamine, chlorambucil, bendamustine, primaquine, oxaliplatin, metronidazole",0.333482019445119,0.151195298948196,FALSE +"H1648","Pearson.est","DNA methyltransferase inhibitor",-0.3482,-0.924,0.499,1437,0.983,"azacitidine",0.30189945437661,0.00744648216786438,FALSE +"H1648","Pearson.est","DNA polymerase inhibitor",-0.47789,-1.31,0.16,1171,1,"cidofovir, menadione, famciclovir",0.795880017344075,0,FALSE +"H1648","Pearson.est","DNA synthesis inhibitor",0.40811,1.02,0.425,523,0.69,"artesunate, azodicarbonamide, mitomycin.c, anisomycin, nelarabine, CB.10.277, enocitabine, artemisinin",0.371611069949688,0.161150909262745,FALSE +"H1648","Pearson.est","dopamine receptor antagonist",-0.30482,-0.833,0.664,1163,1,"nemonapride, piperacetazine, ziprasidone, domperidone, clebopride, remoxipride, acetophenazine",0.177831920631982,0,FALSE +"H1648","Pearson.est","estrogen receptor agonist",0.49819,1.25,0.22,265,0.629,"ethinyl.estradiol, estrone",0.657577319177794,0.201349354554731,FALSE +"H1648","Pearson.est","estrogen receptor antagonist",0.7023,1.81,0.0162,388,0.134,"raloxifene, toremifene, fulvestrant, danazol",1.79048498545737,0.872895201635192,TRUE +"H1648","Pearson.est","FGFR inhibitor",0.47801,1.2,0.235,259,0.594,"regorafenib, dovitinib, erdafitinib, nintedanib",0.628932137728264,0.226213555018806,FALSE +"H1648","Pearson.est","FLT3 inhibitor",0.41601,1.06,0.374,146,0.694,"sorafenib, TG.101348, tyrphostin.AG.1296, dovitinib",0.42712839779952,0.158640529545145,FALSE +"H1648","Pearson.est","glucocorticoid receptor agonist",0.38477,0.968,0.483,557,0.689,"deflazacort, prednisolone.hemisuccinate, fluticasone.propionate, triamcinolone, beclomethasone.dipropionate, rimexolone, prednisolone, betamethasone, ciclesonide, methylprednisolone, prednisolone.acetate, dexamethasone.acetate",0.316052869248488,0.161780778092374,FALSE +"H1648","Pearson.est","glutamate receptor antagonist",0.24142,0.604,0.901,506,0.959,"tiletamine, MTPG, felbamate, IEM1754, LY456236, ACDPP",0.045275209020937,0.0181813928293364,FALSE +"H1648","Pearson.est","glycogen synthase kinase inhibitor",-0.33983,-0.95,0.492,1196,1,"LY2090314, GSK.3.inhibitor.IX, indirubin",0.30803489723264,0,FALSE +"H1648","Pearson.est","growth factor receptor inhibitor",0.53387,1.35,0.152,399,0.585,"danusertib, PHA.848125, GSK1838705A",0.818156412055227,0.23284413391782,FALSE +"H1648","Pearson.est","HCV inhibitor",0.56934,1.45,0.0998,59,0.421,"narlaprevir, mericitabine",1.00086945871263,0.375717904164332,FALSE +"H1648","Pearson.est","HDAC inhibitor",-0.28383,-0.764,0.715,1002,1,"pyroxamide, nexturastat.a, panobinostat, M.344, PCI.24781, SB.939, vorinostat, R306465, romidepsin, tacedinaline, JNJ.26481585",0.145693958198919,0,FALSE +"H1648","Pearson.est","histamine receptor antagonist",-0.27547,-0.751,0.752,1447,1,"chloropyramine",0.123782159408358,0,FALSE +"H1648","Pearson.est","HMGCR inhibitor",0.75801,1.93,0.00328,299,0.0922,"atorvastatin, pitavastatin, fluvastatin, mevastatin, lovastatin",2.48412615628832,1.03526907894637,TRUE +"H1648","Pearson.est","HSP inhibitor",0.33178,0.839,0.648,444,0.844,"SNX.2112, NVP.AUY922, ganetespib, BIIB021, alvespimycin, tanespimycin",0.188424994129407,0.073657553374345,FALSE +"H1648","Pearson.est","JAK inhibitor",-0.28455,-0.765,0.741,1309,1,"TG.02, atiprimod, pacritinib, CEP.33779",0.130181792020672,0,FALSE +"H1648","Pearson.est","KIT inhibitor",0.4354,1.1,0.329,53,0.646,"sorafenib, regorafenib, masitinib",0.482804102050026,0.189767482004916,FALSE +"H1648","Pearson.est","MDM inhibitor",0.2125,0.533,0.975,179,0.985,"AMG.232",0.0109953843014632,0.00656376950238827,FALSE +"H1648","Pearson.est","MEK inhibitor",-0.46878,-1.27,0.177,989,1,"Ro.4987655, refametinib, PD.184352, PD.0325901, AZD8330, nobiletin, TAK.733, PD.198306, MEK162, AS.703026, cobimetinib, trametinib, selumetinib, BIX.02188",0.752026733638193,0,FALSE +"H1648","Pearson.est","MET inhibitor",0.29442,0.732,0.763,79,0.921,"LY2801653",0.11747546204512,0.0357403698031511,FALSE +"H1648","Pearson.est","microtubule inhibitor",0.51549,1.29,0.186,314,0.671,"D.64131, cabazitaxel, secnidazole, podophyllotoxin",0.730487055782084,0.173277479831008,FALSE +"H1648","Pearson.est","mTOR inhibitor",-0.1587,-0.42,0.995,1138,0.997,"PI.103, temsirolimus, LY3023414, PF.05212384, PP242, GSK2126458, WAY.600",0.00217691925427455,0.00130484168834428,FALSE +"H1648","Pearson.est","NFkB pathway inhibitor",-0.34767,-0.936,0.506,1291,1,"betulinic.acid, bindarit, IKK.2.inhibitor.V",0.295849483160201,0,FALSE +"H1648","Pearson.est","opioid receptor agonist",0.47964,1.2,0.251,707,0.594,"trimebutine, spiradoline, salvinorin.a, ADL5859, cebranopadol",0.600326278518962,0.226213555018806,FALSE +"H1648","Pearson.est","p38 MAPK inhibitor",-0.30726,-0.813,0.637,1009,1,"skepinone.l, TAK.715, SB.239063, CMPD.1",0.19586056766465,0,FALSE +"H1648","Pearson.est","PARP inhibitor",0.44472,1.1,0.342,549,0.646,"AZD2461, olaparib, niraparib, talazoparib, AG.14361",0.465973893943865,0.189767482004916,FALSE +"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.38824,0.98,0.479,295,0.737,"sorafenib, regorafenib, masitinib, dovitinib, axitinib, pazopanib, nintedanib, CP.673451",0.319664486585437,0.132532512140949,FALSE +"H1648","Pearson.est","phosphatase inhibitor",0.26831,0.687,0.851,271,0.915,"CID.5458317, GSK2830371, bis.maltolato.oxovanadium.IV.",0.0700704399154121,0.0385789059335517,FALSE +"H1648","Pearson.est","phosphodiesterase inhibitor",-0.28116,-0.725,0.779,1271,1,"zardaverine, cilostamide",0.108462542327436,0,FALSE +"H1648","Pearson.est","PI3K inhibitor",-0.27111,-0.705,0.797,1138,0.974,"PI.103, CUDC.907, alpelisib, pilaralisib, LY3023414, PF.05212384, TG.100713, GSK2126458, CH5132799, idelalisib",0.0985416786038876,0.0114410431213845,FALSE +"H1648","Pearson.est","PLK inhibitor",0.8279,2.08,0,255,0.0361,"volasertib, BI.2536, NMS.1286937, GSK461364, GW.843682X, HMN.214, rigosertib",Inf,1.44249279809434,TRUE +"H1648","Pearson.est","potassium channel blocker",-0.31171,-0.867,0.612,1270,1,"oleoylethanolamide, ibutilide",0.213248577854439,0,FALSE +"H1648","Pearson.est","PPAR receptor agonist",-0.43439,-1.15,0.286,1270,0.922,"oleoylethanolamide, S26948, clofibrate",0.543633966870957,0.0352690789463706,FALSE +"H1648","Pearson.est","progesterone receptor agonist",0.46203,1.17,0.283,405,0.592,"norethindrone, nomegestrol.acetate, norgestrel, tanaproget, danazol, melengestrol.acetate",0.54821356447571,0.22767829327708,FALSE +"H1648","Pearson.est","proteasome inhibitor",-0.2084,-0.556,0.939,1044,0.983,"carfilzomib, MG.132, ixazomib.citrate",0.0273344077338891,0.00744648216786438,FALSE +"H1648","Pearson.est","protein synthesis inhibitor",0.46945,1.17,0.311,394,0.592,"anguidine, mercaptopurine, harringtonine, puromycin, clofoctol, homoharringtonine, cycloheximide, bruceantin, clindamycin.phosphate, thiostrepton, methacycline",0.507239610973163,0.22767829327708,FALSE +"H1648","Pearson.est","protein tyrosine kinase inhibitor",0.40211,1.03,0.419,423,0.696,"mubritinib, PP.121, AV.412, rheochrysidin, tyrphostin.A9",0.377785977033705,0.157390760389438,FALSE +"H1648","Pearson.est","RAF inhibitor",0.35823,0.904,0.561,34,0.778,"sorafenib, regorafenib",0.251037138743839,0.109020403010311,FALSE +"H1648","Pearson.est","RET tyrosine kinase inhibitor",0.58234,1.45,0.0981,34,0.421,"sorafenib, regorafenib",1.00833099262005,0.375717904164332,FALSE +"H1648","Pearson.est","retinoid receptor agonist",-0.36845,-0.972,0.469,1407,1,"CD.437, adarotene",0.328827157284917,0,FALSE +"H1648","Pearson.est","ribonucleotide reductase inhibitor",0.66947,1.72,0.0185,349,0.203,"cladribine, clofarabine, pentostatin, triapine, fludarabine, fludarabine.phosphate, gemcitabine",1.73282827159699,0.692503962086787,TRUE +"H1648","Pearson.est","serotonin receptor agonist",-0.428,-1.15,0.29,1320,0.922,"ipsapirone, aripiprazole",0.537602002101044,0.0352690789463706,FALSE +"H1648","Pearson.est","serotonin receptor antagonist",0.34858,0.872,0.602,55,0.811,"SB.200646, paliperidone",0.220403508742175,0.090979145788844,FALSE +"H1648","Pearson.est","sodium channel blocker",-0.29003,-0.769,0.729,1344,1,"benzethonium, lappaconite",0.137272471682025,0,FALSE +"H1648","Pearson.est","src inhibitor",-0.33978,-0.909,0.543,1272,0.969,"PP.1, saracatinib, PP.2",0.265200170411153,0.0136762229492347,FALSE +"H1648","Pearson.est","sterol demethylase inhibitor",0.59693,1.53,0.0713,476,0.397,"lanoconazole, chlormidazole, ketoconazole, posaconazole, sulconazole",1.14691047014813,0.401209493236885,FALSE +"H1648","Pearson.est","TGF beta receptor inhibitor",-0.40904,-1.1,0.323,1047,0.899,"SB.431542, D.4476, repsox, LY2109761",0.490797477668897,0.0462403082667712,FALSE +"H1648","Pearson.est","thymidylate synthase inhibitor",-0.42788,-1.16,0.269,617,1,"trifluridine, ftorafur, raltitrexed, capecitabine, carmofur, doxifluridine",0.570247719997592,0,FALSE +"H1648","Pearson.est","topoisomerase inhibitor",0.67872,1.71,0.0327,385,0.183,"mitoxantrone, TAS.103, idarubicin, etoposide.phosphate, voreloxin, amsacrine, amonafide, nemorubicin, valrubicin, teniposide, doxorubicin, daunorubicin, SN.38, topotecan, exatecan.mesylate, epirubicin, dexrazoxane, licochalcone.a, rubitecan",1.48545224733971,0.737548910269571,TRUE +"H1648","Pearson.est","tubulin polymerization inhibitor",0.59107,1.5,0.0746,530,0.409,"epothilone.b, docetaxel, CYT.997, dolastatin.10, mebendazole, verubulin, KX2.391, vindesine, fenbendazole, vincristine, podophyllotoxin, BNC105, taltobulin, paclitaxel, flubendazole, oxibendazole, plinabulin, combretastatin.A.4, vinblastine, ABT.751",1.12726117252733,0.388276691992658,FALSE +"H1648","Pearson.est","tyrosine kinase inhibitor",0.41169,1.03,0.416,477,0.696,"mubritinib, sorafenib, regorafenib, hypericin, PP.121, cabozantinib, tyrphostin.AG.99, AV.412, rheochrysidin, tyrphostin.A9, aminopurvalanol.a, bafetinib",0.380906669373257,0.157390760389438,FALSE +"H1648","Pearson.est","VEGFR inhibitor",0.27383,0.713,0.806,318,0.903,"sorafenib, regorafenib, dovitinib, foretinib, tivozanib, axitinib, pazopanib, nintedanib, TG.100572, golvatinib, cabozantinib",0.0936649581949093,0.0443122496864942,FALSE +"H1648","Pearson.est","vitamin D receptor agonist",-0.45741,-1.22,0.237,1267,1,"maxacalcitol, paricalcitol, calcitriol",0.625251653989896,0,FALSE +"H2126","Pearson.est","EGFR inhibitor",-0.57852,-1.44,0.104,1166,0.516,"XL.647, AEE788, OSI.420, AZD8931, poziotinib, dacomitinib, canertinib, afatinib, tucatinib, pelitinib, osimertinib, PD.168393, tyrphostin.AG.1478, neratinib, BIBX.1382, vandetanib, gefitinib, BMS.599626, AST.1306, BIBU.1361, icotinib, CP.724714, WZ8040, erlotinib, PD.153035",0.98296666070122,0.287350298372789,FALSE +"H2126","Pearson.est","Abl kinase inhibitor",0.3849,1.01,0.431,278,0.751,"ponatinib, GZD824, flumatinib, KW.2449, nilotinib",0.365522729839268,0.124360062995832,FALSE +"H2126","Pearson.est","acetylcholine receptor agonist",0.60669,1.63,0.0694,45,0.333,"tremorine, xanomeline",1.15864052954514,0.47755576649368,FALSE +"H2126","Pearson.est","acetylcholine receptor antagonist",-0.79041,-1.99,0.00337,1326,0.0748,"dicycloverine, darifenacin, diphemanil",2.47237009912866,1.12609840213554,TRUE +"H2126","Pearson.est","adenosine receptor antagonist",-0.70155,-1.78,0.012,1225,0.146,"istradefylline, SCH.58261, MRS.1220, CGS.15943",1.92081875395238,0.835647144215563,TRUE +"H2126","Pearson.est","adrenergic receptor agonist",-0.46486,-1.16,0.27,1102,0.675,"oxymetazoline, xylazine, lidamidine, isoetharine, metaraminol, A61603, isoxsuprine",0.568636235841013,0.170696227168975,FALSE +"H2126","Pearson.est","adrenergic receptor antagonist",-0.30115,-0.756,0.736,1214,0.836,"pindolol, imiloxan, dronedarone",0.133122185662501,0.0777937225609836,FALSE +"H2126","Pearson.est","AKT inhibitor",-0.31139,-0.803,0.721,841,0.843,"CCT128930, AZD5363, GSK2110183, triciribine, A.674563, palomid.529",0.142064735280571,0.0741724253752577,FALSE +"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.37064,0.992,0.436,66,0.756,"DMH1, alectinib",0.360513510731414,0.121478204498793,FALSE +"H2126","Pearson.est","androgen receptor antagonist",-0.64317,-1.59,0.0293,1081,0.332,"flutamide, enzalutamide, RU.58841, cyproterone.acetate",1.53313237964589,0.478861916295964,FALSE +"H2126","Pearson.est","antioxidant",-0.45929,-1.16,0.28,880,0.675,"rutin, mesna, chlorogenic.acid, taurine",0.552841968657781,0.170696227168975,FALSE +"H2126","Pearson.est","AP inhibitor",-0.45001,-1.13,0.318,1287,0.662,"tanshinone.i, birinapant",0.497572880015567,0.1791420105603,FALSE +"H2126","Pearson.est","ATPase inhibitor",0.64458,1.76,0.0276,229,0.302,"k.strophanthidin, ouabain, oligomycin.a, digitoxigenin, omeprazole, evodiamine, NMS.873",1.55909091793478,0.519993057042849,FALSE +"H2126","Pearson.est","Aurora kinase inhibitor",0.30927,0.808,0.655,512,0.968,"CCT137690, KW.2449, CCT129202, AMG900, SNS.314, ENMD.2076, barasertib.HQPA, MK.5108, barasertib, aurora.a.inhibitor.i, danusertib, alisertib, MK.8745, PF.03814735, GSK1070916",0.183758700008217,0.0141246426916063,FALSE +"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.25069,0.667,0.838,1087,0.898,"valnemulin, josamycin, radezolid, tedizolid, tilmicosin, azithromycin, azalomycin.b, dirithromycin",0.0767559813697235,0.0467236633326956,FALSE +"H2126","Pearson.est","bacterial DNA gyrase inhibitor",-0.33767,-0.843,0.629,1305,0.831,"trovafloxacin, lomefloxacin",0.201349354554731,0.080398976215889,FALSE +"H2126","Pearson.est","BCL inhibitor",0.31527,0.828,0.634,147,0.995,"ABT.737, navitoclax",0.197910742118267,0.00217691925427455,FALSE +"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.34585,0.946,0.475,278,0.816,"ponatinib, GZD824, flumatinib, nilotinib",0.323306390375133,0.0883098412461389,FALSE +"H2126","Pearson.est","benzodiazepine receptor agonist",-0.30863,-0.768,0.744,1052,0.868,"eprinomectin, CGS.20625, temazepam, gamma.aminobutyric.acid, lorazepam",0.128427064454121,0.0614802748235081,FALSE +"H2126","Pearson.est","bromodomain inhibitor",0.62248,1.65,0.0514,407,0.349,"PFI.1, I.BET151, bromosporine, I.BET.762",1.28903688100472,0.45717457304082,FALSE +"H2126","Pearson.est","calcium channel blocker",-0.37128,-0.917,0.549,1400,0.846,"SKF.96365, mibefradil",0.260427655549908,0.0726296369609765,FALSE +"H2126","Pearson.est","CC chemokine receptor antagonist",0.64532,1.73,0.0358,220,0.285,"UNBS.5162, ZK811752, SB.225002",1.44611697335613,0.54515513999149,FALSE +"H2126","Pearson.est","CDK inhibitor",-0.43096,-1.1,0.333,1112,0.684,"JNJ.7706621, dinaciclib, alvocidib, TG.02, BMS.387032, CR8..R., arcyriaflavin.a, indirubin",0.47755576649368,0.164943898279884,FALSE +"H2126","Pearson.est","CHK inhibitor",-0.45847,-1.14,0.301,927,0.678,"LY2606368, AZD7762, LY2603618, SCH.900776, CHIR.124",0.521433504406157,0.168770306132937,FALSE +"H2126","Pearson.est","cyclooxygenase inhibitor",-0.42495,-1.06,0.366,1320,0.694,"phenylbutazone, tryptanthrin, FK.3311, FR.122047",0.436518914605589,0.158640529545145,FALSE +"H2126","Pearson.est","cytochrome P450 inhibitor",0.26856,0.705,0.827,1061,0.996,"metyrapone, cobicistat, eplerenone, PF.4981517, clotrimazole, morin, itraconazole",0.0824944904474534,0.00174066157630127,FALSE +"H2126","Pearson.est","DNA alkylating agent",0.27125,0.729,0.787,373,1,"cyclophosphamide, dianhydrogalactitol, carmustine, temozolomide, melphalan, estramustine, mitomycin.c, carboplatin",0.104025267640935,0,FALSE +"H2126","Pearson.est","DNA inhibitor",0.2601,0.697,0.834,316,0.928,"chlorambucil, carmustine, teroxirone, oxaliplatin, valrubicin, melphalan",0.0788339493622613,0.0324520237811379,FALSE +"H2126","Pearson.est","DNA methyltransferase inhibitor",0.38344,1.01,0.432,327,0.751,"decitabine, RG108, disulfiram",0.364516253185088,0.124360062995832,FALSE +"H2126","Pearson.est","DNA polymerase inhibitor",0.18331,0.474,0.984,226,0.989,"trifluridine, adefovir.dipivoxil",0.00700490156865849,0.0048037084028206,FALSE +"H2126","Pearson.est","DNA synthesis inhibitor",-0.40562,-1.03,0.404,1418,0.719,"estramustine.phosphate, altretamine",0.393618634889395,0.143271109617117,FALSE +"H2126","Pearson.est","dopamine receptor antagonist",-0.42764,-1.08,0.369,1070,0.689,"sertindole, domperidone, amisulpride, UH.232...., acetophenazine, nemonapride, clebopride, remoxipride, piperacetazine",0.43297363384094,0.161780778092374,FALSE +"H2126","Pearson.est","estrogen receptor agonist",0.34073,0.907,0.553,88,0.864,"ethinyl.estradiol",0.257274868695302,0.0634862575211067,FALSE +"H2126","Pearson.est","estrogen receptor antagonist",0.25867,0.699,0.816,1075,0.976,"toremifene, raloxifene, tamoxifen, danazol, clomifene, fulvestrant",0.0883098412461389,0.0105501823333082,FALSE +"H2126","Pearson.est","FGFR inhibitor",0.48641,1.3,0.18,207,0.556,"erdafitinib, regorafenib, dovitinib, nintedanib",0.744727494896694,0.254925208417942,FALSE +"H2126","Pearson.est","FLT3 inhibitor",0.40619,1.09,0.333,214,0.692,"sorafenib, tyrphostin.AG.1296, ponatinib, TG.101348, dovitinib, KW.2449",0.47755576649368,0.159893905543242,FALSE +"H2126","Pearson.est","glucocorticoid receptor agonist",-0.23011,-0.572,0.927,1446,0.938,"hydrocortisone",0.0329202658555029,0.0277971616209356,FALSE +"H2126","Pearson.est","glutamate receptor antagonist",-0.34743,-0.873,0.595,1341,0.865,"diazooxonorleucine, latrepirdine, JNJ.16259685",0.22548303427145,0.0629838925351858,FALSE +"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.34627,-0.868,0.598,1042,0.843,"kenpaullone, LY2090314, GSK.3.inhibitor.IX, indirubin",0.223298816011589,0.0741724253752577,FALSE +"H2126","Pearson.est","growth factor receptor inhibitor",0.47933,1.28,0.189,130,0.554,"GSK1838705A, PHA.848125",0.723538195826756,0.25649023527157,FALSE +"H2126","Pearson.est","HCV inhibitor",0.42817,1.14,0.329,69,0.698,"narlaprevir, mericitabine",0.482804102050026,0.156144577376839,FALSE +"H2126","Pearson.est","HDAC inhibitor",-0.61769,-1.54,0.0652,1119,0.375,"R306465, vorinostat, scriptaid, nexturastat.a, entinostat, PCI.24781, pyroxamide, panobinostat, M.344, SB.939, tacedinaline, romidepsin, JNJ.26481585",1.18575240426808,0.425968732272281,FALSE +"H2126","Pearson.est","histamine receptor antagonist",-0.4662,-1.18,0.272,1097,0.771,"astemizole, zolantidine, terfenadine, BF2.649, lafutidine, famotidine, ranitidine, chloropyramine",0.565431095965801,0.112945621949043,FALSE +"H2126","Pearson.est","HMGCR inhibitor",0.65288,1.77,0.0271,361,0.574,"atorvastatin, mevastatin, fluvastatin",1.56703070912559,0.241088107602027,FALSE +"H2126","Pearson.est","HSP inhibitor",0.26607,0.706,0.798,212,1,"SNX.2112, NMS.E973, BIIB021, SNX.5422",0.0979971086492706,0,FALSE +"H2126","Pearson.est","JAK inhibitor",-0.33337,-0.855,0.63,1282,0.839,"TG.02, CEP.33779, pacritinib",0.200659450546418,0.0762380391712997,FALSE +"H2126","Pearson.est","KIT inhibitor",0.42473,1.14,0.27,146,0.698,"sorafenib, regorafenib, masitinib, OSI.930",0.568636235841013,0.156144577376839,FALSE +"H2126","Pearson.est","MDM inhibitor",-0.54854,-1.37,0.131,1423,0.613,"RITA",0.882728704344236,0.212539525481585,FALSE +"H2126","Pearson.est","MEK inhibitor",-0.30026,-0.765,0.739,847,0.848,"refametinib, cobimetinib, MEK162, TAK.733, nobiletin, PD.184352, PD.98059, selumetinib, BIX.02188",0.131355561605174,0.0716041477432862,FALSE +"H2126","Pearson.est","MET inhibitor",-0.3654,-0.911,0.555,1133,0.826,"NVP.BVU972, PF.04217903, INC.280",0.255707016877324,0.0830199526796178,FALSE +"H2126","Pearson.est","microtubule inhibitor",0.29409,0.776,0.708,189,0.996,"cabazitaxel, podophyllotoxin, vinblastine",0.149966742310231,0.00174066157630127,FALSE +"H2126","Pearson.est","mTOR inhibitor",-0.46825,-1.18,0.267,893,0.771,"torin.1, SB.2343, torin.2, ku.0063794, LY303511, PKI.179, WYE.125132, sirolimus, everolimus, deforolimus, WAY.600, AZD8055, PI.103, PF.05212384, GDC.0980, GSK2126458, temsirolimus, LY3023414, palomid.529, PP242",0.573488738635425,0.112945621949043,FALSE +"H2126","Pearson.est","NFkB pathway inhibitor",-0.27417,-0.692,0.851,1106,0.895,"IKK.2.inhibitor.V, bindarit, tyloxapol",0.0700704399154121,0.048176964684088,FALSE +"H2126","Pearson.est","opioid receptor agonist",0.30646,0.81,0.649,222,0.997,"spiradoline, trimebutine",0.187755303199631,0.00130484168834428,FALSE +"H2126","Pearson.est","p38 MAPK inhibitor",0.40443,1.09,0.339,9,0.692,"talmapimod",0.469800301796918,0.159893905543242,FALSE +"H2126","Pearson.est","PARP inhibitor",0.53465,1.44,0.101,340,0.437,"niraparib, olaparib, AZD2461, talazoparib",0.995678626217357,0.359518563029578,FALSE +"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.42315,1.13,0.304,224,0.681,"sorafenib, regorafenib, masitinib, ponatinib, dovitinib, axitinib, nintedanib, linifanib",0.517126416391246,0.166852888087215,FALSE +"H2126","Pearson.est","phosphatase inhibitor",-0.24598,-0.615,0.925,1345,0.953,"mycophenolate.mofetil",0.0338582672609674,0.0209070993616736,FALSE +"H2126","Pearson.est","phosphodiesterase inhibitor",-0.53259,-1.34,0.152,1151,0.569,"zardaverine, EMD.53998, GSK256066, anagrelide, cilostamide",0.818156412055227,0.244887733604929,FALSE +"H2126","Pearson.est","PI3K inhibitor",-0.3827,-0.969,0.487,951,0.778,"taselisib, LY303511, PKI.179, TG100.115, YM.201636, TG.100713, alpelisib, PI.103, PF.05212384, GDC.0980, GSK2126458, AZD6482, PI.828, LY3023414, idelalisib, CUDC.907",0.312471038785366,0.109020403010311,FALSE +"H2126","Pearson.est","PLK inhibitor",0.8043,2.15,0.00248,289,0.0508,"volasertib, NMS.1286937, rigosertib, GW.843682X, BI.2536, GSK461364, HMN.214",2.60554831917378,1.29413628771608,TRUE +"H2126","Pearson.est","potassium channel blocker",-0.78218,-1.96,0.00168,1220,0.0553,"meglitinide, oleoylethanolamide, ibutilide",2.77469071827414,1.2572748686953,TRUE +"H2126","Pearson.est","PPAR receptor agonist",-0.67438,-1.7,0.0357,1309,0.205,"S26948, oleoylethanolamide, GW.501516, clofibrate",1.44733178388781,0.688246138944246,TRUE +"H2126","Pearson.est","progesterone receptor agonist",0.24815,0.669,0.863,359,0.918,"norethindrone, norgestrel, nomegestrol.acetate, melengestrol.acetate",0.0639892042847904,0.0371573187987575,FALSE +"H2126","Pearson.est","proteasome inhibitor",0.46738,1.26,0.2,392,0.551,"delanzomib, MG.132, oprozomib, ixazomib",0.698970004336019,0.258848401148215,FALSE +"H2126","Pearson.est","protein synthesis inhibitor",0.28955,0.772,0.721,400,0.971,"anguidine, mercaptopurine, thiostrepton, clofoctol, harringtonine, puromycin, cycloheximide",0.142064735280571,0.0127807700919951,FALSE +"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.46647,-1.17,0.263,1355,0.743,"BMS.599626, CP.724714",0.580044251510242,0.129011186239425,FALSE +"H2126","Pearson.est","RAF inhibitor",0.42529,1.08,0.358,260,0.678,"sorafenib, regorafenib, SB.590885, RAF265",0.446116973356126,0.168770306132937,FALSE +"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.519,1.34,0.152,43,0.57,"sorafenib, regorafenib",0.818156412055227,0.244125144327509,FALSE +"H2126","Pearson.est","retinoid receptor agonist",0.48369,1.3,0.166,219,0.556,"LE.135, fenretinide, tamibarotene",0.779891911959945,0.254925208417942,FALSE +"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.57459,1.51,0.118,71,0.466,"triapine, cladribine",0.928117992693875,0.33161408331,FALSE +"H2126","Pearson.est","serotonin receptor agonist",-0.69804,-1.78,0.0158,1249,0.146,"ipsapirone, NAN.190, aripiprazole",1.80134291304558,0.835647144215563,TRUE +"H2126","Pearson.est","serotonin receptor antagonist",-0.47324,-1.2,0.252,1447,0.843,"aripiprazole",0.598599459218456,0.0741724253752577,FALSE +"H2126","Pearson.est","sodium channel blocker",-0.24006,-0.6,0.92,1300,0.941,"ajmaline, lappaconite",0.0362121726544447,0.0264103765727431,FALSE +"H2126","Pearson.est","src inhibitor",-0.39296,-0.98,0.488,1210,0.786,"bosutinib, PP.1, PP.2",0.311580177997289,0.104577453960592,FALSE +"H2126","Pearson.est","sterol demethylase inhibitor",0.54109,1.46,0.123,390,0.447,"chlormidazole, sulconazole, lanoconazole, posaconazole",0.910094888560602,0.349692476868064,FALSE +"H2126","Pearson.est","TGF beta receptor inhibitor",-0.33501,-0.841,0.635,888,0.809,"repsox, SB.525334, LY2109761, D.4476",0.197226274708024,0.0920514783877277,FALSE +"H2126","Pearson.est","thymidylate synthase inhibitor",0.24585,0.675,0.841,237,0.933,"trifluridine, capecitabine",0.0752040042020878,0.0301183562535,FALSE +"H2126","Pearson.est","topoisomerase inhibitor",0.65994,1.76,0.0221,299,0.302,"etoposide.phosphate, idarubicin, TAS.103, topotecan, mitoxantrone, doxorubicin, voreloxin, nemorubicin, exatecan.mesylate, amonafide, SN.38, teniposide, daunorubicin, valrubicin, amsacrine",1.65560772631489,0.519993057042849,FALSE +"H2126","Pearson.est","tubulin polymerization inhibitor",0.56795,1.5,0.0879,498,0.429,"verubulin, BNC105, vindesine, podophyllotoxin, docetaxel, taltobulin, dolastatin.10, vinblastine, albendazole, combretastatin.A.4, fenbendazole, vincristine, indibulin, CYT.997, mebendazole, plinabulin, epothilone.b, flubendazole, fosbretabulin, KX2.391, parbendazole, oxibendazole, nocodazole, paclitaxel, ABT.751",1.05601112492623,0.367542707815276,FALSE +"H2126","Pearson.est","tyrosine kinase inhibitor",0.20156,0.533,0.971,103,0.99,"sorafenib, regorafenib, hypericin",0.0127807700919951,0.00436480540245009,FALSE +"H2126","Pearson.est","VEGFR inhibitor",0.25982,0.698,0.822,319,0.952,"sorafenib, regorafenib, tivozanib, OSI.930, dovitinib, axitinib, nintedanib, linifanib, RAF265, ENMD.2076, lenvatinib",0.0851281824599496,0.0213630516155257,FALSE +"H2126","Pearson.est","vitamin D receptor agonist",-0.5325,-1.36,0.154,1059,0.577,"tacalcitol, maxacalcitol, calcitriol, paricalcitol",0.812479279163537,0.238824186844269,FALSE +"H520","Pearson.est","EGFR inhibitor",-0.42616,-1.06,0.406,1035,0.742,"BMS.599626, WZ.4002, TAK.285, salvianolic.acid.B, dovitinib, rociletinib, dacomitinib, AZD8931, brigatinib, ARRY.334543, XL.647, AEE788, gefitinib, lapatinib, CP.724714, GW.583340, tucatinib, neratinib",0.391473966422806,0.129596094720973,FALSE +"H520","Pearson.est","Abl kinase inhibitor",-0.41953,-1.03,0.423,843,0.673,"GZD824, dasatinib, bafetinib, bosutinib, flumatinib, ponatinib, metatinib, imatinib, nilotinib",0.373659632624958,0.171984935776023,FALSE +"H520","Pearson.est","acetylcholine receptor agonist",0.33826,0.907,0.53,184,0.716,"nefiracetam, nicotine",0.275724130399211,0.145086977692144,FALSE +"H520","Pearson.est","acetylcholine receptor antagonist",-0.53551,-1.31,0.147,792,0.663,"darifenacin, dicycloverine, methscopolamine, hyoscyamine, diphemanil",0.832682665251824,0.178486471595227,FALSE +"H520","Pearson.est","adenosine receptor antagonist",0.31159,0.808,0.66,999,0.798,"istradefylline, SCH.58261, MRS.1220, sulmazole, PSB.1115, CGS.15943, theophylline",0.180456064458131,0.0979971086492706,FALSE +"H520","Pearson.est","adrenergic receptor agonist",0.28543,0.748,0.771,409,0.864,"oxymetazoline, isoxsuprine, terbutaline, metaraminol, buphenine, ritodrine, epinephrine, clenbuterol, isoetharine",0.112945621949043,0.0634862575211067,FALSE +"H520","Pearson.est","adrenergic receptor antagonist",-0.39914,-0.98,0.478,1056,0.697,"metoprolol, vincamine, practolol, prazosin, idazoxan, carvedilol, RS.17053, dihydroergocristine",0.320572103387881,0.156767221901991,FALSE +"H520","Pearson.est","AKT inhibitor",0.34423,0.916,0.526,371,0.761,"MK.2206, palomid.529, ONC201, AT7867, GDC.0068",0.279014255846261,0.118615343229427,FALSE +"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.42793,-1.05,0.411,1090,0.683,"AZD3463, crizotinib, AP26113, DMH1, brigatinib, CEP.37440",0.386158178123931,0.165579296318467,FALSE +"H520","Pearson.est","androgen receptor antagonist",0.61091,1.61,0.0494,246,0.277,"RU.58841, nilutamide, enzalutamide",1.30627305107635,0.557520230935551,FALSE +"H520","Pearson.est","antioxidant",0.42352,1.12,0.307,123,0.633,"benfotiamine, mesna",0.512861624522813,0.198596289982645,FALSE +"H520","Pearson.est","AP inhibitor",0.61889,1.63,0.0471,47,0.359,"GDC.0152, birinapant",1.3269790928711,0.444905551421681,FALSE +"H520","Pearson.est","ATPase inhibitor",-0.21142,-0.521,0.978,1062,1,"NMS.873, digitoxin, digoxin, evodiamine",0.00966114521239857,0,FALSE +"H520","Pearson.est","Aurora kinase inhibitor",-0.29897,-0.736,0.771,1034,0.849,"MK.8745, CYC116, barasertib.HQPA, SNS.314, AT.9283, ENMD.2076, CCT137690, danusertib, PHA.680632",0.112945621949043,0.0710923097560473,FALSE +"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.39219,-0.976,0.476,1048,0.684,"josamycin, valnemulin, dirithromycin",0.322393047279507,0.164943898279884,FALSE +"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.76902,2.04,0.00735,32,0.0461,"finafloxacin, novobiocin, trovafloxacin",2.13371266091581,1.33629907461035,TRUE +"H520","Pearson.est","BCL inhibitor",-0.34462,-0.83,0.666,1235,0.77,"navitoclax, ABT.737, obatoclax",0.176525770829699,0.113509274827518,FALSE +"H520","Pearson.est","Bcr.Abl kinase inhibitor",-0.57274,-1.41,0.119,843,0.712,"GZD824, dasatinib, bafetinib, bosutinib, flumatinib, ponatinib, metatinib, imatinib, nilotinib",0.924453038607469,0.147520006363144,FALSE +"H520","Pearson.est","benzodiazepine receptor agonist",0.25879,0.678,0.818,182,0.899,"lorazepam, nefiracetam",0.087246696328677,0.0462403082667712,FALSE +"H520","Pearson.est","bromodomain inhibitor",-0.64632,-1.58,0.0537,932,1,"JQ1...., I.BET151, OTX015, PFI.1, bromosporine, I.BET.762",1.27002571430044,0,FALSE +"H520","Pearson.est","calcium channel blocker",0.34296,0.903,0.551,213,0.696,"efonidipine.monoethanolate, cinnarazine, SR.33805, pranidipine",0.258848401148215,0.157390760389438,FALSE +"H520","Pearson.est","CC chemokine receptor antagonist",-0.44017,-1.09,0.34,1285,0.77,"SB.225002, UNBS.5162",0.468521082957745,0.113509274827518,FALSE +"H520","Pearson.est","CDK inhibitor",-0.46221,-1.13,0.301,1140,0.792,"BMS.265246, CR8..R., alvocidib, aminopurvalanol.a, indisulam, PHA.848125, arcyriaflavin.a, dinaciclib, AT.7519, BMS.387032",0.521433504406157,0.101274818410506,FALSE +"H520","Pearson.est","CHK inhibitor",-0.57109,-1.4,0.115,1353,0.661,"SB.218078, PF.477736",0.939302159646388,0.17979854051436,FALSE +"H520","Pearson.est","cyclooxygenase inhibitor",0.25026,0.66,0.858,270,0.891,"metoxibutropate, pterostilbene, acetylsalicylsalicylic.acid, phenylbutazone, indoprofen, suxibuzone, FR.122047",0.0665127121512946,0.0501222959631252,FALSE +"H520","Pearson.est","cytochrome P450 inhibitor",0.24566,0.635,0.896,1094,0.891,"cobicistat, itraconazole, PF.4981517, clotrimazole, morin, eplerenone, metyrapone",0.0476919903378748,0.0501222959631252,FALSE +"H520","Pearson.est","DNA alkylating agent",-0.45512,-1.14,0.295,965,0.809,"melphalan, dacarbazine, ifosfamide, temozolomide, dianhydrogalactitol, mitomycin.c",0.530177984021837,0.0920514783877277,FALSE +"H520","Pearson.est","DNA inhibitor",-0.36565,-0.905,0.543,965,0.707,"melphalan, pibenzimol, teroxirone, oxaliplatin, valrubicin, primaquine, mechlorethamine, bendamustine",0.265200170411153,0.150580586203101,FALSE +"H520","Pearson.est","DNA methyltransferase inhibitor",-0.41706,-1.05,0.396,1244,0.683,"disulfiram, SGI.1027",0.402304814074488,0.165579296318467,FALSE +"H520","Pearson.est","DNA polymerase inhibitor",0.55435,1.46,0.115,209,0.386,"famciclovir, cephalomannine, adefovir.dipivoxil",0.939302159646388,0.413412695328245,FALSE +"H520","Pearson.est","DNA synthesis inhibitor",0.35383,0.938,0.505,100,0.752,"altretamine, CB.10.277, estramustine.phosphate",0.296708621881339,0.123782159408358,FALSE +"H520","Pearson.est","dopamine receptor antagonist",0.41703,1.09,0.347,302,0.579,"clebopride, acetophenazine, oxiperomide, UH.232...., nemonapride, raclopride, remoxipride, paliperidone",0.459670525209126,0.237321436272564,FALSE +"H520","Pearson.est","estrogen receptor agonist",-0.4285,-1.07,0.357,1268,0.751,"equol, levonorgestrel",0.447331783887807,0.124360062995832,FALSE +"H520","Pearson.est","estrogen receptor antagonist",-0.4091,-1.01,0.425,950,0.687,"clomifene, danazol, toremifene, tamoxifen",0.371611069949688,0.16304326294045,FALSE +"H520","Pearson.est","FGFR inhibitor",-0.59727,-1.47,0.0841,1333,0.859,"erdafitinib, nintedanib, regorafenib, lenvatinib",1.07520400420209,0.0660068361687577,FALSE +"H520","Pearson.est","FLT3 inhibitor",-0.35199,-0.86,0.639,961,0.761,"TG.02, sorafenib, lestaurtinib, ponatinib, tyrphostin.AG.1296, dovitinib, ENMD.2076, TG.101348, quizartinib",0.1944991418416,0.118615343229427,FALSE +"H520","Pearson.est","glucocorticoid receptor agonist",-0.45409,-1.14,0.291,1298,0.809,"methylprednisolone, flumethasone, fluorometholone, triamcinolone.acetonide, halcinonide, fluticasone.propionate, betamethasone, deflazacort",0.536107011014093,0.0920514783877277,FALSE +"H520","Pearson.est","glutamate receptor antagonist",-0.30263,-0.758,0.763,1318,0.837,"LY456236, ACDPP, CGP.37849",0.11747546204512,0.07727454200674,FALSE +"H520","Pearson.est","glycogen synthase kinase inhibitor",0.49472,1.32,0.175,132,0.463,"LY2090314, kenpaullone",0.756961951313706,0.334419008982047,FALSE +"H520","Pearson.est","growth factor receptor inhibitor",-0.55445,-1.38,0.131,1025,0.648,"lestaurtinib, AZD3463, PHA.848125, danusertib",0.882728704344236,0.188424994129407,FALSE +"H520","Pearson.est","HCV inhibitor",-0.58066,-1.43,0.11,1251,0.739,"mericitabine, narlaprevir",0.958607314841775,0.131355561605174,FALSE +"H520","Pearson.est","HDAC inhibitor",0.35065,0.912,0.562,142,0.736,"romidepsin, JNJ.26481585, R306465, RGFP966, tacedinaline",0.250263684430939,0.133122185662501,FALSE +"H520","Pearson.est","histamine receptor antagonist",0.37699,0.977,0.464,259,0.748,"epinastine, ranitidine, famotidine, ICI.162846, terfenadine, BF2.649",0.333482019445119,0.126098402135539,FALSE +"H520","Pearson.est","HMGCR inhibitor",0.79889,2.07,0,296,0.0572,"pitavastatin, fluvastatin, lovastatin, mevastatin, atorvastatin, simvastatin",Inf,1.24260397120698,TRUE +"H520","Pearson.est","HSP inhibitor",0.42213,1.14,0.27,312,0.684,"BIIB021, SNX.5422, KW.2478, PU.H71",0.568636235841013,0.164943898279884,FALSE +"H520","Pearson.est","JAK inhibitor",-0.4924,-1.21,0.243,920,0.823,"AZ960, TG.02, lestaurtinib, TG.101209, atiprimod, AT.9283, CEP.33779, baricitinib, LY2784544, TG.101348",0.614393726401688,0.0846001647877302,FALSE +"H520","Pearson.est","KIT inhibitor",-0.53692,-1.32,0.167,1259,0.693,"masitinib, imatinib, pazopanib, regorafenib, lenvatinib",0.777283528852417,0.159266765388193,FALSE +"H520","Pearson.est","MDM inhibitor",0.67715,1.76,0.0289,44,0.243,"RITA, serdemetan",1.53910215724345,0.614393726401688,TRUE +"H520","Pearson.est","MEK inhibitor",0.78307,2.12,0.00276,114,0.0769,"PD.184352, AZD8330, TAK.733, refametinib, Ro.4987655, PD.318088, cobimetinib, PD.0325901, trametinib, MEK162, AS.703026, selumetinib",2.55909091793478,1.11407366019857,TRUE +"H520","Pearson.est","MET inhibitor",0.26917,0.719,0.806,456,0.877,"AMG458, PF.04217903, INC.280, PHA.665752",0.0936649581949093,0.0570004066339595,FALSE +"H520","Pearson.est","microtubule inhibitor",-0.52306,-1.29,0.178,1096,0.665,"triclabendazole, vinflunine, cabazitaxel, colchicine, D.64131",0.749579997691106,0.177178354696895,FALSE +"H520","Pearson.est","mTOR inhibitor",-0.37906,-0.958,0.474,1051,0.658,"torin.1, AZD2014, PKI.179, deforolimus, PF.05212384, AZD8055, MLN0128, WYE.354, PF.04691502, WYE.125132",0.324221658325915,0.181774106386044,FALSE +"H520","Pearson.est","NFkB pathway inhibitor",0.44344,1.15,0.281,2,0.716,"BAY.11.7085",0.55129368009492,0.145086977692144,FALSE +"H520","Pearson.est","opioid receptor agonist",0.43368,1.13,0.302,300,0.655,"ADL5859, cebranopadol, BW.180C",0.519993057042849,0.183758700008217,FALSE +"H520","Pearson.est","p38 MAPK inhibitor",-0.42114,-1.05,0.396,1446,0.683,"talmapimod",0.402304814074488,0.165579296318467,FALSE +"H520","Pearson.est","PARP inhibitor",-0.21072,-0.511,0.971,779,0.995,"endo.IWR.1, E7449, niraparib, PJ.34",0.0127807700919951,0.00217691925427455,FALSE +"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.39545,-0.971,0.49,1259,0.673,"masitinib, imatinib, pazopanib, nintedanib, regorafenib, lenvatinib, crenolanib",0.309803919971486,0.171984935776023,FALSE +"H520","Pearson.est","phosphatase inhibitor",0.33585,0.88,0.595,99,0.706,"bis.maltolato.oxovanadium.IV., alexidine",0.22548303427145,0.151195298948196,FALSE +"H520","Pearson.est","phosphodiesterase inhibitor",0.54111,1.42,0.119,292,0.364,"papaverine, anagrelide, GSK256066, zardaverine, EMD.53998",0.924453038607469,0.438898616350944,FALSE +"H520","Pearson.est","PI3K inhibitor",-0.31982,-0.792,0.707,984,0.808,"idelalisib, NVP.BEZ235, alpelisib, BGT226, PKI.179, PIK.75, YM.201636, taselisib, PI3K.IN.2, ZSTK.474, PF.05212384, PF.04691502",0.150580586203101,0.0925886392254138,FALSE +"H520","Pearson.est","PLK inhibitor",-0.83067,-2.05,0,1297,0.0322,"HMN.214, GW.843682X, GSK461364, BI.2536, volasertib, NMS.1286937",Inf,1.49214412830417,TRUE +"H520","Pearson.est","potassium channel blocker",0.53756,1.44,0.115,26,0.375,"meglitinide",0.939302159646388,0.425968732272281,FALSE +"H520","Pearson.est","PPAR receptor agonist",0.55589,1.51,0.0735,321,0.359,"S26948, pterostilbene, clofibrate, fenofibrate",1.1337126609158,0.444905551421681,FALSE +"H520","Pearson.est","progesterone receptor agonist",-0.1938,-0.479,0.983,907,0.985,"nomegestrol.acetate, melengestrol.acetate, danazol, levonorgestrel",0.00744648216786438,0.00656376950238827,FALSE +"H520","Pearson.est","proteasome inhibitor",-0.27153,-0.674,0.861,874,0.91,"delanzomib, oprozomib, MG.132, bortezomib, carfilzomib",0.0649968485463452,0.0409586076789064,FALSE +"H520","Pearson.est","protein synthesis inhibitor",-0.50035,-1.2,0.264,1415,0.799,"bruceantin, harringtonine, anguidine, homoharringtonine",0.578396073130169,0.0974532206860086,FALSE +"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.63181,-1.55,0.0456,1193,0.943,"PP.121, mubritinib, tyrphostin.A9, AV.412, CP.724714",1.34103515733556,0.0254883072626717,FALSE +"H520","Pearson.est","RAF inhibitor",-0.38302,-0.935,0.523,972,0.678,"PLX.4720, sorafenib, SB.590885, AZ.628, regorafenib, TAK.632",0.281498311132726,0.168770306132937,FALSE +"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.4226,-1.04,0.399,934,0.678,"cabozantinib, sorafenib, regorafenib",0.399027104313252,0.168770306132937,FALSE +"H520","Pearson.est","retinoid receptor agonist",-0.48036,-1.19,0.262,1204,0.775,"bexarotene, tamibarotene, fenretinide, adarotene",0.581698708680255,0.11069829749369,FALSE +"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.40181,-0.997,0.457,1327,0.688,"LY2334737, pentostatin",0.34008379993015,0.162411561764489,FALSE +"H520","Pearson.est","serotonin receptor agonist",0.60578,1.62,0.0629,1,0.31,"aripiprazole",1.20134935455473,0.508638306165727,FALSE +"H520","Pearson.est","serotonin receptor antagonist",0.43105,1.09,0.311,180,0.579,"aripiprazole, lerisetron, tropisetron",0.507239610973163,0.237321436272564,FALSE +"H520","Pearson.est","sodium channel blocker",0.40666,1.09,0.331,64,0.579,"ajmaline, A.803467",0.480172006224281,0.237321436272564,FALSE +"H520","Pearson.est","src inhibitor",-0.45555,-1.12,0.337,1077,0.776,"PP.1, TG.100572, masitinib, KX2.391, saracatinib",0.472370099128661,0.110138278741812,FALSE +"H520","Pearson.est","sterol demethylase inhibitor",-0.58558,-1.45,0.098,1083,0.789,"ketoconazole, lanoconazole, posaconazole, chlormidazole",1.00877392430751,0.10292299679058,FALSE +"H520","Pearson.est","TGF beta receptor inhibitor",0.3516,0.942,0.512,941,0.779,"D.4476, LY2109761, SB.431542, repsox, adaprev, SB.525334",0.290730039024169,0.108462542327436,FALSE +"H520","Pearson.est","thymidylate synthase inhibitor",-0.43257,-1.07,0.382,1313,0.751,"doxifluridine",0.417936637088291,0.124360062995832,FALSE +"H520","Pearson.est","topoisomerase inhibitor",-0.54462,-1.32,0.178,1137,0.693,"licochalcone.a, valrubicin, etoposide, daunorubicin, etoposide.phosphate, doxorubicin, teniposide, amonafide, idarubicin, nemorubicin, TAS.103, dexrazoxane, exatecan.mesylate, amsacrine, mitoxantrone, SN.38",0.749579997691106,0.159266765388193,FALSE +"H520","Pearson.est","tubulin polymerization inhibitor",-0.59443,-1.48,0.0864,1135,1,"vindesine, vincristine, plinabulin, docetaxel, epothilone.d, epothilone.b, taltobulin, dolastatin.10, paclitaxel, ABT.751, mebendazole, CYT.997, oxibendazole, fenbendazole, KX2.391",1.06348625752111,0,FALSE +"H520","Pearson.est","tyrosine kinase inhibitor",-0.45019,-1.1,0.332,894,0.784,"dasatinib, bafetinib, cabozantinib, sorafenib, tyrphostin.AG.99, BMS.599626, PP.121, mubritinib, tivantinib, tyrphostin.A9, aminopurvalanol.a, AV.412, CP.724714, regorafenib",0.478861916295964,0.105683937315562,FALSE +"H520","Pearson.est","VEGFR inhibitor",-0.33548,-0.836,0.64,1247,0.779,"ENMD.2076, pazopanib, foretinib, XL.647, nintedanib, AEE788, regorafenib, lenvatinib",0.193820026016113,0.108462542327436,FALSE +"H520","Pearson.est","vitamin D receptor agonist",-0.39273,-0.962,0.487,1416,0.669,"doxercalciferol",0.312471038785366,0.174573882232177,FALSE +"H460","Pearson.est","EGFR inhibitor",-0.15743,-0.402,0.998,881,0.997,"osimertinib, brigatinib, WZ8040, tyrphostin.AG.1478, vandetanib, tucatinib, CGP.52411, BMS.599626, PD.168393, BIBU.1361, lapatinib, neratinib, rociletinib, WZ.4002, dovitinib, CP.724714, salvianolic.acid.B",0.000869458712628891,0.00130484168834428,FALSE +"H460","Pearson.est","Abl kinase inhibitor",-0.48144,-1.22,0.226,1269,0.669,"ponatinib, metatinib, nilotinib, imatinib",0.645891560852599,0.174573882232177,FALSE +"H460","Pearson.est","acetylcholine receptor agonist",-0.41258,-1.05,0.376,1353,0.566,"oxiracetam",0.424812155072339,0.247183568811729,FALSE +"H460","Pearson.est","acetylcholine receptor antagonist",0.71905,1.9,0.0168,115,0.192,"iododexetimide, diphemanil, darifenacin",1.77469071827414,0.71669877129645,TRUE +"H460","Pearson.est","adenosine receptor antagonist",0.46854,1.25,0.209,345,0.513,"CGS.15943, MRS.1220, SCH.58261",0.679853713888946,0.289882634888184,FALSE +"H460","Pearson.est","adrenergic receptor agonist",0.55126,1.51,0.078,72,0.328,"ritodrine, isoxsuprine, methyldopa, xylazine",1.10790539730952,0.484126156288321,FALSE +"H460","Pearson.est","adrenergic receptor antagonist",0.42837,1.12,0.295,287,0.617,"prazosin, RS.17053, atenolol...., metoprolol, practolol, atenolol......",0.530177984021837,0.209714835966758,FALSE +"H460","Pearson.est","AKT inhibitor",0.31824,0.841,0.657,183,0.794,"GDC.0068, palomid.529, GSK2110183, triciribine",0.182434630440219,0.100179497572904,FALSE +"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.54912,1.45,0.13,202,0.338,"GW.788388, lorlatinib, NVP.TAE684, SB.505124",0.886056647693163,0.471083299722345,FALSE +"H460","Pearson.est","androgen receptor antagonist",0.36209,0.96,0.468,544,0.738,"nilutamide, enzalutamide, bicalutamide, flutamide",0.329754146925876,0.131943638176958,FALSE +"H460","Pearson.est","antioxidant",-0.41131,-1.05,0.389,1085,0.566,"trolox, chlorogenic.acid, mesna",0.410050398674292,0.247183568811729,FALSE +"H460","Pearson.est","AP inhibitor",0.28153,0.744,0.722,78,0.809,"tanshinone.i",0.141462802430361,0.0920514783877277,FALSE +"H460","Pearson.est","ATPase inhibitor",-0.31124,-0.805,0.693,990,0.769,"omeprazole, NMS.873, ouabain, digitoxigenin, digoxin, digitoxin",0.159266765388193,0.114073660198569,FALSE +"H460","Pearson.est","Aurora kinase inhibitor",-0.5357,-1.4,0.119,1016,0.496,"alisertib, AMG900, KW.2449, GSK1070916, CCT137690, CCT129202, PF.03814735, CYC116, MK.8745, hesperadin, ENMD.2076, MK.5108, PHA.680632",0.924453038607469,0.304518323509803,FALSE +"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.4366,-1.11,0.326,1208,0.586,"tedizolid, azalomycin.b, radezolid, valnemulin",0.486782399932061,0.232102383981909,FALSE +"H460","Pearson.est","bacterial DNA gyrase inhibitor",0.59799,1.62,0.0563,193,0.374,"sparfloxacin, norfloxacin, nadifloxacin, trovafloxacin",1.24949160514865,0.42712839779952,FALSE +"H460","Pearson.est","BCL inhibitor",-0.50509,-1.29,0.181,1145,0.562,"ABT.737, navitoclax, TW.37, venetoclax",0.742321425130815,0.250263684430939,FALSE +"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.56204,-1.43,0.114,1269,0.587,"ponatinib, metatinib, nilotinib, imatinib",0.943095148663527,0.231361898752386,FALSE +"H460","Pearson.est","benzodiazepine receptor agonist",0.5712,1.51,0.0637,220,0.328,"indiplon, gamma.aminobutyric.acid, CL.218872, temazepam, nefiracetam, piperazine",1.19586056766465,0.484126156288321,FALSE +"H460","Pearson.est","bromodomain inhibitor",-0.40614,-1.05,0.383,1121,0.566,"bromosporine, I.BET.762",0.416801226031377,0.247183568811729,FALSE +"H460","Pearson.est","calcium channel blocker",0.29375,0.751,0.757,399,0.825,"SKF.96365, efonidipine.monoethanolate, pranidipine, tetrandrine",0.120904120499927,0.0835460514500749,FALSE +"H460","Pearson.est","CC chemokine receptor antagonist",-0.49699,-1.3,0.163,1195,0.578,"navarixin, RS.504393",0.787812395596042,0.238072161579471,FALSE +"H460","Pearson.est","CDK inhibitor",-0.68197,-1.77,0.0158,1087,0.266,"NU6027, AT.7519, TG.02, PHA.848125, dinaciclib, BMS.387032, AZD5438, aminopurvalanol.a, indirubin, abemaciclib, palbociclib, alvocidib, PHA.793887, BMS.265246, ribociclib",1.80134291304558,0.575118363368933,FALSE +"H460","Pearson.est","CHK inhibitor",-0.42986,-1.13,0.297,973,0.574,"AZD7762, SB.218078, LY2603618, SCH.900776",0.527243550682788,0.241088107602027,FALSE +"H460","Pearson.est","cyclooxygenase inhibitor",0.27113,0.726,0.807,278,0.809,"naproxen, pterostilbene, metoxibutropate, phenylbutazone, FK.3311",0.0931264652779296,0.0920514783877277,FALSE +"H460","Pearson.est","cytochrome P450 inhibitor",0.71109,1.86,0.0147,230,0.165,"itraconazole, morin, metyrapone, eplerenone",1.83268266525182,0.782516055786094,TRUE +"H460","Pearson.est","DNA alkylating agent",-0.43757,-1.13,0.313,986,0.574,"carmustine, melphalan, estramustine, TH.302, dianhydrogalactitol, carboplatin, mitomycin.c",0.504455662453552,0.241088107602027,FALSE +"H460","Pearson.est","DNA inhibitor",-0.4731,-1.18,0.286,1356,0.585,"teroxirone, carboplatin, valrubicin, mechlorethamine",0.543633966870957,0.23284413391782,FALSE +"H460","Pearson.est","DNA methyltransferase inhibitor",-0.46625,-1.19,0.259,1304,0.596,"disulfiram, decitabine",0.586700235918748,0.224753740259764,FALSE +"H460","Pearson.est","DNA polymerase inhibitor",0.46545,1.24,0.212,290,0.493,"famciclovir, cephalomannine, cidofovir, menadione",0.673664139071249,0.30715308072277,FALSE +"H460","Pearson.est","DNA synthesis inhibitor",-0.42548,-1.09,0.347,1213,0.576,"enocitabine, capecitabine, floxuridine, anisomycin, cyclocytidine, mitomycin.c",0.459670525209126,0.239577516576788,FALSE +"H460","Pearson.est","dopamine receptor antagonist",0.28946,0.778,0.732,201,0.84,"clebopride, nemonapride, domperidone, sertindole",0.135488918941608,0.0757207139381184,FALSE +"H460","Pearson.est","estrogen receptor agonist",-0.28956,-0.741,0.777,1132,0.823,"equol, PPT",0.109578981199086,0.0846001647877302,FALSE +"H460","Pearson.est","estrogen receptor antagonist",0.58023,1.56,0.0907,219,0.34,"toremifene, raloxifene, fulvestrant",1.0423927129399,0.468521082957745,FALSE +"H460","Pearson.est","FGFR inhibitor",0.40683,1.1,0.33,196,0.583,"lucitanib, orantinib, erdafitinib",0.481486060122112,0.234331445240986,FALSE +"H460","Pearson.est","FLT3 inhibitor",-0.41817,-1.05,0.381,1040,0.566,"midostaurin, KW.2449, TG.02, sunitinib, quizartinib, pacritinib, ponatinib, dovitinib, ENMD.2076, TG.101348",0.419075024324381,0.247183568811729,FALSE +"H460","Pearson.est","glucocorticoid receptor agonist",0.27046,0.719,0.814,17,0.794,"triamcinolone.acetonide, piretanide",0.0893755951107988,0.100179497572904,FALSE +"H460","Pearson.est","glutamate receptor antagonist",0.41508,1.11,0.317,261,0.6,"JNJ.16259685, kynurenic.acid, MTPG, CGP.37849",0.498940737782249,0.221848749616356,FALSE +"H460","Pearson.est","glycogen synthase kinase inhibitor",0.32811,0.878,0.573,265,0.823,"CHIR.99021, CHIR.98014, GSK.3.inhibitor.IX",0.24184537803261,0.0846001647877302,FALSE +"H460","Pearson.est","growth factor receptor inhibitor",-0.47753,-1.21,0.238,717,0.651,"GW.441756, GSK1838705A, danusertib, lestaurtinib, PHA.848125",0.623423042943488,0.186419011431808,FALSE +"H460","Pearson.est","HCV inhibitor",-0.38894,-0.994,0.464,1236,0.601,"mericitabine, narlaprevir",0.333482019445119,0.22112552799726,FALSE +"H460","Pearson.est","HDAC inhibitor",-0.55081,-1.42,0.109,1004,0.549,"NSC.3852, panobinostat, romidepsin, SB.939, scriptaid, mocetinostat, PCI.24781, JNJ.26481585, AR.42, M.344, resminostat, vorinostat, entinostat, RG2833, dacinostat, trichostatin.a, chidamide, givinostat",0.962573502059376,0.260427655549908,FALSE +"H460","Pearson.est","histamine receptor antagonist",0.3674,0.959,0.46,299,0.708,"famotidine, chloropyramine, epinastine, cimetidine, tecastemizole, lafutidine, ebastine",0.337242168318426,0.149966742310231,FALSE +"H460","Pearson.est","HMGCR inhibitor",0.69079,1.85,0.0189,288,0.133,"lovastatin, atorvastatin, mevastatin, fluvastatin",1.72353819582676,0.876148359032914,TRUE +"H460","Pearson.est","HSP inhibitor",-0.44508,-1.13,0.273,1298,0.574,"NVP.AUY922, PU.H71, VER.49009, ganetespib, tanespimycin",0.563837352959244,0.241088107602027,FALSE +"H460","Pearson.est","JAK inhibitor",-0.53032,-1.38,0.142,1125,0.497,"TG.02, TG.101209, WHI.P154, AZ960, pacritinib, TG.101348, filgotinib",0.847711655616944,0.303643611266668,FALSE +"H460","Pearson.est","KIT inhibitor",-0.31484,-0.809,0.674,1144,0.781,"KI.8751, sunitinib, OSI.930, vatalanib, imatinib",0.17134010346468,0.1073489661227,FALSE +"H460","Pearson.est","MDM inhibitor",-0.6425,-1.64,0.0384,1138,0.458,"RITA, CGM097, nutlin.3, idasanutlin",1.41566877563247,0.339134521996131,FALSE +"H460","Pearson.est","MEK inhibitor",-0.56662,-1.47,0.0841,1139,0.551,"cobimetinib, nobiletin, PD.318088, PD.184352, Ro.4987655, PD.0325901, MEK162, AZD8330, TAK.733, trametinib, selumetinib, AS.703026",1.07520400420209,0.258848401148215,FALSE +"H460","Pearson.est","MET inhibitor",0.36524,0.964,0.467,449,0.766,"AMG458, INC.280, PF.04217903, PHA.665752",0.330683119433888,0.115771230367396,FALSE +"H460","Pearson.est","microtubule inhibitor",-0.32113,-0.809,0.696,1284,0.781,"vinflunine, D.64131",0.157390760389438,0.1073489661227,FALSE +"H460","Pearson.est","mTOR inhibitor",-0.39943,-1,0.436,895,0.61,"XL388, deforolimus, torin.1, WAY.600, voxtalisib, LY3023414, sirolimus, PP242, AZD8055, WYE.354, WYE.125132, LY303511, temsirolimus, ku.0063794, GDC.0980, AZD2014, MLN0128, everolimus, NVP.BEZ235",0.360513510731414,0.214670164989233,FALSE +"H460","Pearson.est","NFkB pathway inhibitor",0.28782,0.773,0.721,221,0.82,"tyloxapol, parthenolide...., bindarit",0.142064735280571,0.0861861476162833,FALSE +"H460","Pearson.est","opioid receptor agonist",-0.4652,-1.19,0.275,1367,0.596,"salvinorin.a",0.560667306169737,0.224753740259764,FALSE +"H460","Pearson.est","p38 MAPK inhibitor",0.42433,1.13,0.31,428,0.638,"TAK.715, SB.239063, CMPD.1",0.508638306165727,0.195179321278838,FALSE +"H460","Pearson.est","PARP inhibitor",-0.40586,-1.03,0.402,1142,0.58,"endo.IWR.1, niraparib, talazoparib, olaparib",0.39577394691553,0.236572006437063,FALSE +"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.4805,-1.19,0.271,1130,0.596,"linifanib, KI.8751, trapidil, sunitinib, vatalanib, ponatinib, crenolanib, dovitinib, axitinib, imatinib",0.567030709125594,0.224753740259764,FALSE +"H460","Pearson.est","phosphatase inhibitor",0.59818,1.57,0.0596,486,0.381,"BVT.948, alexidine, AS.1949490, menadione, mycophenolic.acid, mycophenolate.mofetil, sodium.stibogluconate",1.22475374025976,0.419075024324381,FALSE +"H460","Pearson.est","phosphodiesterase inhibitor",0.31354,0.843,0.623,289,0.821,"enoximone, GSK256066, avanafil",0.20551195334083,0.0856568428805592,FALSE +"H460","Pearson.est","PI3K inhibitor",-0.24252,-0.613,0.907,1301,0.929,"GDC.0980, PIK.75, NVP.BEZ235",0.0423927129399047,0.0319842860063582,FALSE +"H460","Pearson.est","PLK inhibitor",-0.80764,-2.06,0.00187,1163,0.0648,"HMN.214, GSK461364, GW.843682X, BI.2536, rigosertib, NMS.1286937, volasertib",2.7281583934635,1.18842499412941,TRUE +"H460","Pearson.est","potassium channel blocker",0.3973,1.04,0.406,13,0.656,"dofetilide",0.391473966422806,0.18309616062434,FALSE +"H460","Pearson.est","PPAR receptor agonist",0.7643,2.04,0.00239,171,0.117,"pterostilbene, S26948, fenofibrate, GW.501516",2.62160209905186,0.931814138253838,TRUE +"H460","Pearson.est","progesterone receptor agonist",0.48312,1.27,0.197,483,0.517,"norgestrel, norethindrone, norethindrone.acetate, dienogest, nomegestrol.acetate",0.705533773838407,0.286509456906058,FALSE +"H460","Pearson.est","proteasome inhibitor",0.56026,1.47,0.106,342,0.345,"oprozomib, delanzomib, ONX.0914, MG.132",0.97469413473523,0.462180904926726,FALSE +"H460","Pearson.est","protein synthesis inhibitor",-0.26005,-0.654,0.857,1173,0.91,"tedizolid.phosphate, emetine, thiostrepton, homoharringtonine, anguidine",0.0670191780768018,0.0409586076789064,FALSE +"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.59982,-1.5,0.073,1296,0.637,"AV.412, CP.724714, mubritinib",1.13667713987954,0.19586056766465,FALSE +"H460","Pearson.est","RAF inhibitor",-0.33828,-0.868,0.623,1099,0.731,"CEP.32496, TAK.632, vemurafenib, dabrafenib",0.20551195334083,0.13608262304214,FALSE +"H460","Pearson.est","RET tyrosine kinase inhibitor",0.3316,0.857,0.607,76,0.828,"apatinib",0.216811308924742,0.0819696632151199,FALSE +"H460","Pearson.est","retinoid receptor agonist",-0.42137,-1.09,0.341,1050,0.576,"LE.135, CD.437, bexarotene, adarotene",0.467245621007502,0.239577516576788,FALSE +"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.45817,-1.16,0.296,917,0.595,"cladribine, triapine, pentostatin, clofarabine, LY2334737, gemcitabine, fludarabine",0.528708288941061,0.22548303427145,FALSE +"H460","Pearson.est","serotonin receptor antagonist",-0.30265,-0.758,0.746,1374,0.818,"SB.200646, SB.216641",0.127261172527331,0.087246696328677,FALSE +"H460","Pearson.est","sodium channel blocker",0.3101,0.801,0.697,357,0.832,"cibenzoline, benzocaine, benzethonium, oxcarbazepine, ajmaline",0.156767221901991,0.0798766737092761,FALSE +"H460","Pearson.est","src inhibitor",-0.34407,-0.876,0.596,1227,0.738,"TG.100572, KX2.391",0.224753740259764,0.131943638176958,FALSE +"H460","Pearson.est","sterol demethylase inhibitor",-0.69164,-1.8,0.0144,1289,0.322,"lanoconazole, ketoconazole",1.84163750790475,0.492144128304169,FALSE +"H460","Pearson.est","TGF beta receptor inhibitor",0.50725,1.36,0.135,465,0.42,"LY2109761, repsox, SB.525334, D.4476",0.869666231504994,0.3767507096021,FALSE +"H460","Pearson.est","thymidylate synthase inhibitor",-0.58002,-1.47,0.0915,1224,0.551,"capecitabine, trifluridine, carmofur",1.03857890593355,0.258848401148215,FALSE +"H460","Pearson.est","topoisomerase inhibitor",-0.55579,-1.41,0.103,1357,0.52,"voreloxin, licochalcone.a, TAS.103, valrubicin, idarubicin, amsacrine, amonafide, mitoxantrone",0.987162775294828,0.283996656365201,FALSE +"H460","Pearson.est","tubulin polymerization inhibitor",-0.57816,-1.5,0.0692,951,0.637,"podophyllotoxin, plinabulin, vinblastine, vindesine, nocodazole, CYT.997, fenbendazole, BNC105, dolastatin.10, docetaxel, taltobulin, epothilone.d, flubendazole, ABT.751, verubulin, combretastatin.A.4, parbendazole, fosbretabulin, KX2.391, epothilone.b",1.15989390554324,0.19586056766465,FALSE +"H460","Pearson.est","tyrosine kinase inhibitor",-0.36431,-0.926,0.539,919,0.675,"tivantinib, vandetanib, dasatinib, NVP.TAE226, BMS.599626, UNC2250, hypericin, AMG.208, sunitinib, aminopurvalanol.a, AV.412, CP.724714, tyrphostin.AG.99, mubritinib",0.268411234813261,0.170696227168975,FALSE +"H460","Pearson.est","VEGFR inhibitor",-0.3832,-0.968,0.494,1130,0.624,"linifanib, KI.8751, MGCD.265, tivozanib, sunitinib, OSI.930, TG.100572, vatalanib, semaxanib, foretinib, golvatinib, dovitinib, ENMD.2076, axitinib",0.306273051076353,0.204815410317576,FALSE +"H460","Pearson.est","vitamin D receptor agonist",-0.52738,-1.33,0.157,1244,0.557,"ercalcitriol, tacalcitol, doxercalciferol",0.804100347590766,0.254144804826271,FALSE +"H1299","Pearson.est","EGFR inhibitor",0.52411,1.36,0.141,399,0.845,"OSI.420, tyrphostin.AG.1478, erlotinib, BIBX.1382, gefitinib, WZ8040, BIBU.1361, CP.724714, icotinib, AZD8931, osimertinib, canertinib, dacomitinib, PD.153035, pelitinib, AST.1306, poziotinib, tyrphostin.AG.494, BMS.690514, afatinib, lapatinib, neratinib, ARRY.334543, XL.647, CGP.52411",0.85078088734462,0.0731432910503077,FALSE +"H1299","Pearson.est","Abl kinase inhibitor",-0.57572,-1.46,0.103,999,0.305,"metatinib, dasatinib, bafetinib, nilotinib, flumatinib, GZD824, ponatinib",0.987162775294828,0.515700160653214,FALSE +"H1299","Pearson.est","acetylcholine receptor agonist",0.29053,0.737,0.772,75,1,"nefiracetam",0.112382699664264,0,FALSE +"H1299","Pearson.est","acetylcholine receptor antagonist",0.27836,0.711,0.798,427,0.975,"darifenacin, diphemanil, dicycloverine",0.0979971086492706,0.0109953843014632,FALSE +"H1299","Pearson.est","adenosine receptor antagonist",0.84895,2.18,0,44,0.0115,"SCH.58261, CGS.15943, MRS.1220, PSB.1115",Inf,1.93930215964639,TRUE +"H1299","Pearson.est","adrenergic receptor agonist",0.49404,1.29,0.181,341,0.707,"oxymetazoline, lidamidine, metaraminol, methyldopa, clenbuterol, isoxsuprine",0.742321425130815,0.150580586203101,FALSE +"H1299","Pearson.est","adrenergic receptor antagonist",0.35931,0.942,0.512,131,0.878,"levobunolol, atenolol...., imiloxan, dronedarone",0.290730039024169,0.0565054840938974,FALSE +"H1299","Pearson.est","AKT inhibitor",0.49167,1.27,0.198,332,0.695,"CCT128930, uprosertib, GDC.0068, palomid.529, AZD5363",0.703334809738469,0.158015195409886,FALSE +"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.41485,1.07,0.361,91,0.742,"NVP.TAE684, GW.788388",0.442492798094342,0.129596094720973,FALSE +"H1299","Pearson.est","androgen receptor antagonist",0.61489,1.58,0.0698,443,0.391,"enzalutamide, cyproterone.acetate, RU.58841",1.15614457737684,0.407823242604133,FALSE +"H1299","Pearson.est","antioxidant",0.35859,0.913,0.549,511,0.87,"benfotiamine, taurine, chlorogenic.acid, mesna",0.260427655549908,0.0604807473813815,FALSE +"H1299","Pearson.est","AP inhibitor",-0.46966,-1.2,0.247,1430,0.499,"idronoxil",0.607303046740334,0.30189945437661,FALSE +"H1299","Pearson.est","ATPase inhibitor",-0.5271,-1.38,0.13,1107,0.334,"digitoxigenin, thonzonium, ouabain, k.strophanthidin, digoxin, oligomycin.a",0.886056647693163,0.476253533188435,FALSE +"H1299","Pearson.est","Aurora kinase inhibitor",-0.41057,-1.07,0.392,1283,0.527,"MK.5108, CYC116, AMG900, aurora.a.inhibitor.i, CCT137690",0.406713932979543,0.278189384787453,FALSE +"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.45826,-1.18,0.278,1269,0.479,"josamycin, valnemulin",0.555955204081924,0.319664486585437,FALSE +"H1299","Pearson.est","bacterial DNA gyrase inhibitor",0.1778,0.455,0.996,130,1,"finafloxacin",0.00174066157630127,0,FALSE +"H1299","Pearson.est","BCL inhibitor",-0.3412,-0.905,0.54,1299,0.694,"gossypol, ABT.737",0.267606240177031,0.158640529545145,FALSE +"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.6032,-1.57,0.0683,999,0.274,"metatinib, dasatinib, bafetinib, nilotinib, flumatinib, GZD824, ponatinib",1.16557929631847,0.562249437179612,FALSE +"H1299","Pearson.est","benzodiazepine receptor agonist",0.4891,1.24,0.215,241,0.71,"gamma.aminobutyric.acid, nefiracetam, lorazepam, piperazine, eprinomectin",0.667561540084395,0.148741651280925,FALSE +"H1299","Pearson.est","bromodomain inhibitor",-0.32149,-0.844,0.619,970,0.745,"OTX015, bromosporine, PFI.1",0.208309350979882,0.127843727251707,FALSE +"H1299","Pearson.est","calcium channel blocker",-0.31032,-0.819,0.676,1438,0.74,"carboxyamidotriazole",0.170053304058364,0.130768280269024,FALSE +"H1299","Pearson.est","CC chemokine receptor antagonist",-0.44067,-1.16,0.271,1423,0.443,"UNBS.5162",0.567030709125594,0.35359627377693,FALSE +"H1299","Pearson.est","CDK inhibitor",0.43316,1.13,0.311,357,0.727,"indirubin, JNJ.7706621, arcyriaflavin.a, BMS.387032, kenpaullone, alvocidib, AZD5438, P276.00, TG.02",0.507239610973163,0.138465589140962,FALSE +"H1299","Pearson.est","CHK inhibitor",-0.54659,-1.46,0.1,1077,0.305,"LY2606368, AZD7762, PF.477736",1,0.515700160653214,FALSE +"H1299","Pearson.est","cyclooxygenase inhibitor",0.3016,0.776,0.734,262,0.981,"tryptanthrin, FK.3311, phenylbutazone, FR.122047, pterostilbene, amfenac",0.134303940083929,0.0083309926200515,FALSE +"H1299","Pearson.est","cytochrome P450 inhibitor",0.46511,1.21,0.232,213,0.606,"PF.4981517, morin, itraconazole",0.6345120151091,0.217527375833714,FALSE +"H1299","Pearson.est","DNA alkylating agent",0.22143,0.555,0.941,160,1,"dacarbazine, ifosfamide",0.0264103765727431,0,FALSE +"H1299","Pearson.est","DNA inhibitor",-0.296,-0.753,0.768,1145,0.769,"pibenzimol, primaquine, teroxirone, tirapazamine, chlorambucil, valrubicin",0.114638779968488,0.114073660198569,FALSE +"H1299","Pearson.est","DNA methyltransferase inhibitor",0.34063,0.881,0.577,19,0.904,"azacitidine",0.238824186844269,0.0438315695246367,FALSE +"H1299","Pearson.est","DNA polymerase inhibitor",0.47361,1.22,0.237,15,0.622,"famciclovir",0.625251653989896,0.206209615309181,FALSE +"H1299","Pearson.est","DNA synthesis inhibitor",0.28468,0.727,0.778,125,1,"altretamine, estramustine.phosphate",0.109020403010311,0,FALSE +"H1299","Pearson.est","dopamine receptor antagonist",0.40979,1.06,0.365,305,0.73,"acetophenazine, ziprasidone, domperidone, remoxipride, oxiperomide, mesoridazine, nemonapride, sertindole",0.437707135543525,0.136677139879544,FALSE +"H1299","Pearson.est","estrogen receptor agonist",-0.32551,-0.83,0.621,806,0.745,"estradiol.cypionate, equol, estradiol, estrone, levonorgestrel",0.20690839982342,0.127843727251707,FALSE +"H1299","Pearson.est","estrogen receptor antagonist",-0.61653,-1.57,0.0707,1122,0.274,"tamoxifen, raloxifene, toremifene",1.1505805862031,0.562249437179612,FALSE +"H1299","Pearson.est","FGFR inhibitor",-0.56745,-1.49,0.0941,1284,0.318,"nintedanib, lenvatinib, dovitinib, erdafitinib, regorafenib",1.02641037657274,0.497572880015567,FALSE +"H1299","Pearson.est","FLT3 inhibitor",-0.53138,-1.4,0.154,1199,0.33,"midostaurin, TG.101348, tyrphostin.AG.1296, dovitinib, quizartinib, sorafenib, ponatinib",0.812479279163537,0.481486060122112,FALSE +"H1299","Pearson.est","glucocorticoid receptor agonist",0.13267,0.337,0.998,1095,1,"hydrocortisone, flumethasone, dexamethasone.acetate, fludroxycortide, desonide, betamethasone, triamcinolone.acetonide, piretanide, fluocinolone.acetonide, difluprednate, halcinonide, clobetasol.propionate, methylprednisolone, prednisolone.hemisuccinate, ciclesonide, prednisolone, beclomethasone.dipropionate, triamcinolone, rimexolone, fluticasone.propionate, flumethasone.pivalate, fluorometholone, halobetasol.propionate, prednisolone.acetate",0.000869458712628891,0,FALSE +"H1299","Pearson.est","glutamate receptor antagonist",0.42895,1.12,0.321,207,0.71,"diazooxonorleucine, kynurenic.acid, latrepirdine, JNJ.16259685",0.493494967595128,0.148741651280925,FALSE +"H1299","Pearson.est","glycogen synthase kinase inhibitor",0.35816,0.915,0.543,74,0.899,"indirubin, CHIR.99021",0.265200170411153,0.0462403082667712,FALSE +"H1299","Pearson.est","growth factor receptor inhibitor",0.40705,1.03,0.402,105,0.757,"GSK1904529A",0.39577394691553,0.120904120499927,FALSE +"H1299","Pearson.est","HCV inhibitor",-0.40467,-1.05,0.372,1268,0.517,"mericitabine, narlaprevir",0.429457060118102,0.286509456906058,FALSE +"H1299","Pearson.est","HDAC inhibitor",0.50533,1.3,0.18,228,0.823,"tacedinaline, nexturastat.a, romidepsin, JNJ.26481585, pyroxamide, vorinostat, panobinostat, R306465",0.744727494896694,0.0846001647877302,FALSE +"H1299","Pearson.est","histamine receptor antagonist",0.28064,0.713,0.786,444,1,"terfenadine, ranitidine, famotidine, levocetirizine, chloropyramine, astemizole, tecastemizole, pheniramine, epinastine",0.104577453960592,0,FALSE +"H1299","Pearson.est","HMGCR inhibitor",-0.65924,-1.69,0.0243,1047,0.347,"simvastatin, mevastatin, fluvastatin, atorvastatin, pitavastatin",1.61439372640169,0.459670525209126,FALSE +"H1299","Pearson.est","HSP inhibitor",-0.289,-0.738,0.786,908,0.768,"VER.49009, tanespimycin, PU.H71, BIIB021, alvespimycin, NVP.AUY922, SNX.2112, ganetespib",0.104577453960592,0.114638779968488,FALSE +"H1299","Pearson.est","JAK inhibitor",0.25473,0.634,0.877,414,1,"CEP.33779, atiprimod, pacritinib, TG.02, LY2784544, WHI.P154",0.0570004066339595,0,FALSE +"H1299","Pearson.est","KIT inhibitor",-0.6447,-1.63,0.042,1031,0.314,"dasatinib, vatalanib, sunitinib, telatinib, midostaurin, masitinib, lenvatinib, pazopanib, sorafenib, regorafenib",1.3767507096021,0.503070351926785,FALSE +"H1299","Pearson.est","MDM inhibitor",0.63403,1.58,0.0462,388,0.391,"nutlin.3, CGM097, idasanutlin, RITA",1.33535802444387,0.407823242604133,FALSE +"H1299","Pearson.est","MEK inhibitor",0.7328,1.87,0.00388,309,0.217,"selumetinib, AS.703026, PD.0325901, cobimetinib, BIX.02188, MEK162, trametinib, PD.198306, Ro.4987655, refametinib, TAK.733, AZD8330, PD.184352",2.41116827440579,0.66354026615147,TRUE +"H1299","Pearson.est","MET inhibitor",-0.418,-1.06,0.372,1179,0.52,"NVP.BVU972, LY2801653",0.429457060118102,0.283996656365201,FALSE +"H1299","Pearson.est","microtubule inhibitor",-0.48765,-1.25,0.219,1121,0.453,"podophyllotoxin, vinblastine, secnidazole, D.64131, cabazitaxel",0.659555885159882,0.343901797987168,FALSE +"H1299","Pearson.est","mTOR inhibitor",0.17796,0.451,0.994,403,1,"PP242, XL388, palomid.529, torin.2, PI.103, LY303511, WAY.600, PF.05212384, AZD8055, OSI.027",0.00261361560268669,0,FALSE +"H1299","Pearson.est","NFkB pathway inhibitor",0.3885,1,0.425,393,0.787,"bindarit, betulinic.acid, parthenolide...., IKK.2.inhibitor.V, tyloxapol",0.371611069949688,0.104025267640935,FALSE +"H1299","Pearson.est","opioid receptor agonist",0.26491,0.678,0.826,1066,0.996,"salvinorin.a, BW.180C, spiradoline, ADL5859, cebranopadol, trimebutine",0.0830199526796178,0.00174066157630127,FALSE +"H1299","Pearson.est","p38 MAPK inhibitor",0.51996,1.31,0.169,418,0.887,"SB.239063, skepinone.l, TAK.715, SB.242235, CMPD.1",0.772113295386326,0.0520763801682736,FALSE +"H1299","Pearson.est","PARP inhibitor",0.33235,0.84,0.62,268,0.897,"PJ.34, endo.IWR.1",0.207608310501746,0.0472075569559079,FALSE +"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.59954,-1.55,0.0684,1003,0.272,"SU014813, CP.673451, dasatinib, vatalanib, sunitinib, telatinib, linifanib, axitinib, masitinib, crenolanib, nintedanib, lenvatinib, dovitinib, pazopanib, sorafenib, ponatinib, regorafenib",1.16494389827988,0.565431095965801,FALSE +"H1299","Pearson.est","phosphatase inhibitor",-0.39818,-1,0.419,1188,0.568,"GSK2830371, CID.5458317, bis.maltolato.oxovanadium.IV.",0.377785977033705,0.245651664288981,FALSE +"H1299","Pearson.est","phosphodiesterase inhibitor",0.62809,1.63,0.0528,198,0.7,"cilostamide, zardaverine, GSK256066, anagrelide",1.27736607746619,0.154901959985743,FALSE +"H1299","Pearson.est","PI3K inhibitor",0.22054,0.579,0.939,377,1,"CH5132799, pilaralisib, alpelisib, AZD6482, PI.828, idelalisib, PI.103, LY303511, PF.05212384, TG100.115, TG.100713",0.0273344077338891,0,FALSE +"H1299","Pearson.est","PLK inhibitor",-0.8043,-2.12,0,1159,0.0408,"GW.843682X, rigosertib, HMN.214, NMS.1286937, volasertib, GSK461364, BI.2536",Inf,1.38933983691012,TRUE +"H1299","Pearson.est","potassium channel blocker",0.47404,1.23,0.225,261,0.683,"oleoylethanolamide, ibutilide",0.647817481888638,0.165579296318467,FALSE +"H1299","Pearson.est","PPAR receptor agonist",0.47777,1.22,0.264,355,0.622,"S26948, oleoylethanolamide, pterostilbene, clofibrate",0.578396073130169,0.206209615309181,FALSE +"H1299","Pearson.est","progesterone receptor agonist",-0.30979,-0.8,0.716,1026,0.746,"melengestrol.acetate, levonorgestrel, nomegestrol.acetate, norethindrone, norgestrel, tanaproget",0.145086977692144,0.127261172527331,FALSE +"H1299","Pearson.est","proteasome inhibitor",-0.42417,-1.09,0.36,1341,0.521,"delanzomib",0.443697499232713,0.283162276700476,FALSE +"H1299","Pearson.est","protein synthesis inhibitor",-0.32809,-0.856,0.585,1024,0.749,"clofoctol, cycloheximide, homoharringtonine, bruceantin, harringtonine, puromycin, mercaptopurine, anguidine",0.23284413391782,0.125518182300534,FALSE +"H1299","Pearson.est","protein tyrosine kinase inhibitor",-0.44667,-1.16,0.269,1162,0.443,"AV.412, tyrphostin.A9, rheochrysidin, mubritinib",0.570247719997592,0.35359627377693,FALSE +"H1299","Pearson.est","RAF inhibitor",-0.45206,-1.18,0.279,1193,0.479,"PLX.4720, RAF265, TAK.632, sorafenib, regorafenib",0.554395796726402,0.319664486585437,FALSE +"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.61639,-1.6,0.0407,1082,0.31,"sunitinib, cabozantinib, sorafenib, regorafenib",1.39040559077478,0.508638306165727,FALSE +"H1299","Pearson.est","retinoid receptor agonist",-0.28872,-0.753,0.741,1295,0.769,"LE.135, fenretinide",0.130181792020672,0.114073660198569,FALSE +"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.73811,-1.91,0.00849,1319,0.0964,"LY2334737, triapine, pentostatin, gemcitabine, clofarabine, cladribine",2.07109230975605,1.01592296609717,TRUE +"H1299","Pearson.est","serotonin receptor agonist",0.62784,1.61,0.0506,283,0.586,"aripiprazole, ipsapirone, SR.57227A",1.2958494831602,0.232102383981909,FALSE +"H1299","Pearson.est","serotonin receptor antagonist",0.41903,1.07,0.371,310,0.742,"aripiprazole, ziprasidone, SB.228357, sertindole, tropisetron",0.430626090384954,0.129596094720973,FALSE +"H1299","Pearson.est","sodium channel blocker",0.33988,0.872,0.589,460,0.865,"lappaconite, benzethonium, A.803467, triamterene, ajmaline, mexiletine, butamben",0.229884705212898,0.0629838925351858,FALSE +"H1299","Pearson.est","src inhibitor",0.33054,0.872,0.616,220,0.865,"PP.2, PP.1, saracatinib",0.210419287835575,0.0629838925351858,FALSE +"H1299","Pearson.est","sterol demethylase inhibitor",-0.54516,-1.4,0.127,1087,0.33,"sulconazole, ketoconazole, chlormidazole, lanoconazole",0.896196279044043,0.481486060122112,FALSE +"H1299","Pearson.est","TGF beta receptor inhibitor",0.60935,1.58,0.0686,219,0.391,"LY2109761, D.4476",1.16367588429325,0.407823242604133,FALSE +"H1299","Pearson.est","thymidylate synthase inhibitor",0.24364,0.616,0.915,209,1,"carmofur",0.0385789059335517,0,FALSE +"H1299","Pearson.est","topoisomerase inhibitor",-0.73381,-1.93,0.00198,1275,0.117,"epirubicin, etoposide, licochalcone.a, SN.38, nemorubicin, teniposide, amsacrine, voreloxin, exatecan.mesylate, doxorubicin, amonafide, daunorubicin, valrubicin, etoposide.phosphate, idarubicin, TAS.103, mitoxantrone",2.70333480973847,0.931814138253838,TRUE +"H1299","Pearson.est","tubulin polymerization inhibitor",-0.63239,-1.63,0.0483,1073,0.314,"nocodazole, oxibendazole, podophyllotoxin, ABT.751, parbendazole, vincristine, CYT.997, KX2.391, vindesine, verubulin, taltobulin, vinblastine, BNC105, fenbendazole, dolastatin.10, epothilone.b, flubendazole, mebendazole, docetaxel",1.31605286924849,0.503070351926785,FALSE +"H1299","Pearson.est","tyrosine kinase inhibitor",-0.44798,-1.16,0.274,1031,0.443,"dasatinib, bafetinib, sunitinib, tyrphostin.AG.99, AV.412, cabozantinib, hypericin, tyrphostin.A9, rheochrysidin, sorafenib, mubritinib, regorafenib",0.562249437179612,0.35359627377693,FALSE +"H1299","Pearson.est","VEGFR inhibitor",-0.49011,-1.26,0.202,1044,0.465,"vatalanib, MK.2461, sunitinib, telatinib, cabozantinib, linifanib, axitinib, TG.100572, RAF265, nintedanib, lenvatinib, dovitinib, golvatinib, pazopanib, sorafenib, tivozanib, foretinib, regorafenib",0.694648630553376,0.332547047110046,FALSE +"H1299","Pearson.est","vitamin D receptor agonist",0.51264,1.29,0.197,233,0.707,"maxacalcitol, ercalcitriol, calcitriol, paricalcitol",0.705533773838407,0.150580586203101,FALSE +"HCC44","Pearson.est","EGFR inhibitor",0.1722,0.429,0.998,14,0.996,"GW.583340, AEE788",0.000869458712628891,0.00174066157630127,FALSE +"HCC44","Pearson.est","Abl kinase inhibitor",0.32028,0.797,0.688,400,0.904,"flumatinib, ZM.306416, bafetinib, ponatinib, bosutinib, metatinib, GZD824",0.162411561764489,0.0438315695246367,FALSE +"HCC44","Pearson.est","acetylcholine receptor agonist",-0.44067,-1.13,0.31,981,0.54,"oxiracetam, nefiracetam, nicotine",0.508638306165727,0.267606240177031,FALSE +"HCC44","Pearson.est","acetylcholine receptor antagonist",0.66113,1.66,0.0295,287,0.464,"iododexetimide, darifenacin, diphemanil, hyoscyamine",1.53017798402184,0.333482019445119,FALSE +"HCC44","Pearson.est","adenosine receptor antagonist",-0.33137,-0.843,0.629,1395,0.849,"PSB.1115",0.201349354554731,0.0710923097560473,FALSE +"HCC44","Pearson.est","adrenergic receptor agonist",-0.23497,-0.589,0.927,1226,0.953,"metaraminol, clenbuterol, oxymetazoline",0.0329202658555029,0.0209070993616736,FALSE +"HCC44","Pearson.est","adrenergic receptor antagonist",-0.33035,-0.848,0.63,1347,0.873,"atipamezole, levobunolol, dronedarone, imiloxan",0.200659450546418,0.0589857562944303,FALSE +"HCC44","Pearson.est","AKT inhibitor",-0.51981,-1.31,0.185,904,0.525,"palomid.529, MK.2206, AT7867, CCT128930, GDC.0068, ONC201, uprosertib",0.732828271596986,0.279840696594043,FALSE +"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.36815,0.951,0.488,617,0.952,"AP26113, NVP.TAE684, CEP.37440, brigatinib, lorlatinib, AZD3463, GW.788388, SB.505124, DMH1",0.311580177997289,0.0213630516155257,FALSE +"HCC44","Pearson.est","androgen receptor antagonist",-0.47859,-1.2,0.27,1427,0.553,"RU.58841",0.568636235841013,0.257274868695302,FALSE +"HCC44","Pearson.est","antioxidant",-0.46658,-1.21,0.242,1037,0.573,"taurine, chlorogenic.acid, benfotiamine, mesna",0.616184634019569,0.24184537803261,FALSE +"HCC44","Pearson.est","AP inhibitor",0.32324,0.83,0.675,277,0.951,"idronoxil, embelin",0.170696227168975,0.0218194830625861,FALSE +"HCC44","Pearson.est","ATPase inhibitor",-0.42522,-1.11,0.34,1135,0.544,"digoxin, ouabain, thonzonium",0.468521082957745,0.26440110030182,FALSE +"HCC44","Pearson.est","Aurora kinase inhibitor",-0.63083,-1.57,0.0573,1180,0.568,"barasertib, CCT129202, ENMD.2076, hesperadin, tozasertib, alisertib, GSK1070916, MK.8745, KW.2449, PF.03814735, MLN.8054",1.24184537803261,0.245651664288981,FALSE +"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.45877,1.14,0.305,34,1,"josamycin, dirithromycin",0.515700160653214,0,FALSE +"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.47814,-1.21,0.259,1301,0.573,"trovafloxacin, novobiocin, finafloxacin",0.586700235918748,0.24184537803261,FALSE +"HCC44","Pearson.est","BCL inhibitor",-0.37637,-0.939,0.5,1281,0.809,"venetoclax, HA14.1, oridonin",0.301029995663981,0.0920514783877277,FALSE +"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",0.38991,0.987,0.451,400,0.947,"flumatinib, bafetinib, ponatinib, bosutinib, metatinib, GZD824",0.345823458122039,0.0236500209967266,FALSE +"HCC44","Pearson.est","benzodiazepine receptor agonist",-0.26417,-0.69,0.845,1176,0.965,"zaleplon, eprinomectin, lorazepam, CGS.20625, ivermectin",0.0731432910503077,0.0154726866562074,FALSE +"HCC44","Pearson.est","bromodomain inhibitor",-0.3035,-0.762,0.713,1050,0.956,"OTX015, JQ1...., I.BET.762",0.146910470148134,0.0195421077238999,FALSE +"HCC44","Pearson.est","calcium channel blocker",0.31635,0.823,0.657,162,0.909,"carboxyamidotriazole, fendiline",0.182434630440219,0.0414361167780325,FALSE +"HCC44","Pearson.est","CC chemokine receptor antagonist",0.36698,0.932,0.528,141,0.925,"UNBS.5162, MK.0812",0.277366077466188,0.0338582672609674,FALSE +"HCC44","Pearson.est","CDK inhibitor",-0.58614,-1.51,0.0862,1103,0.596,"P276.00, abemaciclib, indisulam, R547, TG.02, BMS.265246, indirubin, JNJ.7706621, alvocidib, palbociclib, PHA.793887, ribociclib, kenpaullone, AZD5438",1.06449273417529,0.224753740259764,FALSE +"HCC44","Pearson.est","CHK inhibitor",0.46693,1.2,0.261,414,1,"PF.477736, LY2606368, SB.218078",0.583359492661719,0,FALSE +"HCC44","Pearson.est","cyclooxygenase inhibitor",0.22839,0.59,0.912,354,1,"AM.404, naproxen, tepoxalin, FK.3311, acetylsalicylsalicylic.acid, metoxibutropate, pterostilbene, phenazone",0.0400051616715838,0,FALSE +"HCC44","Pearson.est","cytochrome P450 inhibitor",0.43107,1.09,0.376,367,1,"metyrapone, clotrimazole, cobicistat, morin",0.424812155072339,0,FALSE +"HCC44","Pearson.est","DNA alkylating agent",0.19426,0.48,0.988,55,1,"dianhydrogalactitol",0.00524305541237188,0,FALSE +"HCC44","Pearson.est","DNA inhibitor",-0.28278,-0.714,0.807,1233,0.997,"carboplatin, carmustine, nimorazole, busulfan",0.0931264652779296,0.00130484168834428,FALSE +"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.4555,-1.17,0.276,1250,0.534,"fdcyd, decitabine, azacitidine",0.559090917934782,0.272458742971444,FALSE +"HCC44","Pearson.est","DNA polymerase inhibitor",-0.52379,-1.34,0.158,950,0.635,"famciclovir, adefovir.dipivoxil, cidofovir, trifluridine, foscarnet",0.801342913045577,0.197226274708024,FALSE +"HCC44","Pearson.est","DNA synthesis inhibitor",0.32856,0.826,0.667,262,0.931,"enocitabine, estramustine.phosphate, nelarabine, azodicarbonamide, artesunate",0.175874166083451,0.0310503190186574,FALSE +"HCC44","Pearson.est","dopamine receptor antagonist",-0.51751,-1.33,0.183,1144,0.538,"UH.232...., domperidone, remoxipride, mesoridazine, oxiperomide, clebopride, ziprasidone, acetophenazine",0.737548910269571,0.269217724333611,FALSE +"HCC44","Pearson.est","estrogen receptor agonist",0.32984,0.838,0.654,196,0.963,"levonorgestrel, estradiol.cypionate",0.184422251675733,0.0163737128754655,FALSE +"HCC44","Pearson.est","estrogen receptor antagonist",0.81727,2.08,0,260,0.0543,"toremifene, raloxifene, fulvestrant, tamoxifen, danazol",Inf,1.26520017041115,TRUE +"HCC44","Pearson.est","FGFR inhibitor",0.71665,1.85,0.0203,288,0.175,"lenvatinib, erdafitinib, regorafenib, AZD4547, dovitinib, orantinib, nintedanib",1.69250396208679,0.756961951313706,TRUE +"HCC44","Pearson.est","FLT3 inhibitor",-0.2571,-0.655,0.875,1175,0.978,"TG.02, ENMD.2076, tozasertib, tandutinib, KW.2449",0.0579919469776868,0.00966114521239857,FALSE +"HCC44","Pearson.est","glucocorticoid receptor agonist",0.31048,0.792,0.69,363,0.889,"deflazacort, clobetasol.propionate, fluorometholone, triamcinolone.acetonide, fluticasone.propionate, halcinonide, betamethasone, flumethasone.pivalate",0.161150909262745,0.0510982390297863,FALSE +"HCC44","Pearson.est","glutamate receptor antagonist",0.36367,0.916,0.55,119,0.927,"LY456236, CGP.37849, MTPG",0.259637310505756,0.0329202658555029,FALSE +"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.45757,-1.19,0.247,1391,0.535,"kenpaullone, LY2090314",0.607303046740334,0.271646217978772,FALSE +"HCC44","Pearson.est","growth factor receptor inhibitor",-0.34629,-0.886,0.572,499,0.839,"AZD3463, GW.441756, danusertib, lestaurtinib, PHA.848125, GSK1838705A, GSK1904529A",0.242603971206976,0.0762380391712997,FALSE +"HCC44","Pearson.est","HCV inhibitor",0.24472,0.617,0.904,442,1,"embelin, PSI.7976, mericitabine",0.0438315695246367,0,FALSE +"HCC44","Pearson.est","HDAC inhibitor",-0.54697,-1.41,0.124,1093,0.56,"AR.42, resminostat, scriptaid, belinostat, pyroxamide, vorinostat, PCI.24781, tacedinaline, trichostatin.a, givinostat, JNJ.26481585, panobinostat, R306465, romidepsin",0.906578314837765,0.2518119729938,FALSE +"HCC44","Pearson.est","histamine receptor antagonist",0.34051,0.872,0.588,350,0.923,"tiotidine, ebastine, chloropyramine, tecastemizole, astemizole, ICI.162846, BF2.649, nizatidine",0.230622673923862,0.0347982989740879,FALSE +"HCC44","Pearson.est","HMGCR inhibitor",0.65861,1.65,0.0378,325,0.392,"lovastatin, mevastatin, pitavastatin",1.42250820016277,0.406713932979543,FALSE +"HCC44","Pearson.est","HSP inhibitor",-0.548,-1.43,0.139,963,0.688,"SNX.2112, VER.49009, KW.2478, tanespimycin, ganetespib, SNX.5422, XL888, NVP.AUY922, BIIB021",0.856985199745905,0.162411561764489,FALSE +"HCC44","Pearson.est","JAK inhibitor",0.19812,0.51,0.99,166,1,"PRT062070, ruxolitinib",0.00436480540245009,0,FALSE +"HCC44","Pearson.est","KIT inhibitor",0.31625,0.8,0.707,167,0.924,"lenvatinib, regorafenib, pazopanib, telatinib",0.150580586203101,0.0343280287798933,FALSE +"HCC44","Pearson.est","MDM inhibitor",-0.67651,-1.73,0.038,1178,0.319,"RITA, CGM097, nutlin.3, idasanutlin",1.42021640338319,0.496209316942819,FALSE +"HCC44","Pearson.est","MEK inhibitor",-0.86064,-2.18,0,1397,0.0112,"PD.318088, selumetinib, PD.184352, MEK162, TAK.733, AS.703026, Ro.4987655, AZD8330, cobimetinib, trametinib, PD.0325901, refametinib",Inf,1.95078197732982,TRUE +"HCC44","Pearson.est","MET inhibitor",0.27659,0.687,0.854,418,1,"INC.280, NVP.BVU972, LY2801653",0.068542129310995,0,FALSE +"HCC44","Pearson.est","microtubule inhibitor",0.37092,0.944,0.508,286,0.933,"estramustine.phosphate, colchicine, cabazitaxel, D.64131, triclabendazole",0.294136287716081,0.0301183562535,FALSE +"HCC44","Pearson.est","mTOR inhibitor",-0.24397,-0.621,0.879,1122,0.984,"NVP.BEZ235, torin.2, GSK2126458, LY303511, voxtalisib, PP242, XL388",0.0560111249262281,0.00700490156865849,FALSE +"HCC44","Pearson.est","NFkB pathway inhibitor",0.35277,0.894,0.573,257,0.94,"tyloxapol, BAY.11.7082, bindarit, EVP4593",0.24184537803261,0.0268721464003014,FALSE +"HCC44","Pearson.est","opioid receptor agonist",-0.49841,-1.27,0.202,873,0.549,"trimebutine, ADL5859, BW.180C, salvinorin.a, cebranopadol",0.694648630553376,0.260427655549908,FALSE +"HCC44","Pearson.est","p38 MAPK inhibitor",0.37812,0.967,0.482,281,0.954,"VX.702, SB.242235, talmapimod",0.31695296176115,0.0204516252959049,FALSE +"HCC44","Pearson.est","PARP inhibitor",-0.45222,-1.16,0.271,1280,0.521,"niraparib, olaparib, talazoparib",0.567030709125594,0.283162276700476,FALSE +"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.34502,0.881,0.572,370,0.935,"lenvatinib, regorafenib, pazopanib, telatinib, dovitinib, orantinib, nintedanib, ponatinib, masitinib",0.242603971206976,0.0291883891274822,FALSE +"HCC44","Pearson.est","phosphatase inhibitor",0.39319,1.01,0.439,423,0.978,"BVT.948, AS.1949490, GSK2830371, CID.5458317, bis.maltolato.oxovanadium.IV.",0.357535479757879,0.00966114521239857,FALSE +"HCC44","Pearson.est","phosphodiesterase inhibitor",-0.23819,-0.613,0.908,1283,0.961,"zardaverine, anagrelide",0.0419141514789149,0.0172766123314547,FALSE +"HCC44","Pearson.est","PI3K inhibitor",-0.28055,-0.705,0.81,1122,0.975,"NVP.BEZ235, pilaralisib, GSK2126458, alpelisib, LY303511, voxtalisib, TG.100713, CUDC.907, CH5132799",0.0915149811213502,0.0109953843014632,FALSE +"HCC44","Pearson.est","PLK inhibitor",0.53324,1.34,0.172,271,1,"GSK461364, BI.2536, NMS.1286937",0.764471553092451,0,FALSE +"HCC44","Pearson.est","potassium channel blocker",-0.5574,-1.42,0.115,1269,0.614,"oleoylethanolamide, ML133, meglitinide",0.939302159646388,0.211831628858832,FALSE +"HCC44","Pearson.est","PPAR receptor agonist",0.45423,1.18,0.242,351,1,"GW.501516, fenofibrate, clofibrate, pterostilbene",0.616184634019569,0,FALSE +"HCC44","Pearson.est","progesterone receptor agonist",0.58997,1.45,0.114,283,0.841,"nomegestrol.acetate, levonorgestrel, norgestrel, danazol, norethindrone.acetate",0.943095148663527,0.0752040042020878,FALSE +"HCC44","Pearson.est","proteasome inhibitor",0.25278,0.638,0.874,1084,1,"delanzomib, oprozomib, ONX.0914, carfilzomib, MG.132, ixazomib, ixazomib.citrate, bortezomib",0.058488567365597,0,FALSE +"HCC44","Pearson.est","protein synthesis inhibitor",0.44154,1.13,0.302,234,0.978,"anguidine, mercaptopurine, clindamycin.phosphate, homoharringtonine, clofoctol, puromycin, bruceantin, harringtonine",0.519993057042849,0.00966114521239857,FALSE +"HCC44","Pearson.est","protein tyrosine kinase inhibitor",0.3819,0.994,0.453,110,0.972,"rheochrysidin, tyrphostin.A9",0.343901797987168,0.0123337350737254,FALSE +"HCC44","Pearson.est","RAF inhibitor",0.25403,0.646,0.885,550,1,"regorafenib, CEP.32496, PLX.4720, LGX818, TAK.632, RAF265, sorafenib, GDC.0879",0.0530567293021746,0,FALSE +"HCC44","Pearson.est","RET tyrosine kinase inhibitor",0.42006,1.07,0.4,522,1,"regorafenib, sorafenib, cabozantinib",0.397940008672038,0,FALSE +"HCC44","Pearson.est","retinoid receptor agonist",0.48596,1.24,0.198,424,1,"fenretinide, AM.580, bexarotene, LE.135",0.703334809738469,0,FALSE +"HCC44","Pearson.est","ribonucleotide reductase inhibitor",0.53393,1.33,0.168,330,0.989,"pentostatin, LY2334737, clofarabine, gemcitabine, hydroxyurea",0.774690718274137,0.0048037084028206,FALSE +"HCC44","Pearson.est","serotonin receptor agonist",-0.778,-1.98,0.00411,1207,0.0582,"ipsapirone, SR.57227A, aripiprazole",2.38615817812393,1.23507701535011,TRUE +"HCC44","Pearson.est","serotonin receptor antagonist",-0.51628,-1.33,0.164,1072,0.538,"RS.16566, tropisetron, lerisetron, pirenperone, ziprasidone, aripiprazole",0.785156151952302,0.269217724333611,FALSE +"HCC44","Pearson.est","sodium channel blocker",0.40412,1.01,0.435,63,0.978,"oxcarbazepine, cibenzoline",0.361510743045363,0.00966114521239857,FALSE +"HCC44","Pearson.est","src inhibitor",0.50585,1.29,0.192,396,1,"ZM.306416, TG.100572, PP.1, saracatinib, masitinib, bosutinib, KX2.391",0.71669877129645,0,FALSE +"HCC44","Pearson.est","sterol demethylase inhibitor",0.72388,1.86,0.0161,313,0.243,"ketoconazole, lanoconazole, posaconazole, terconazole",1.79317412396815,0.614393726401688,TRUE +"HCC44","Pearson.est","TGF beta receptor inhibitor",0.44296,1.15,0.294,447,1,"adaprev, LY2109761, SB.525334",0.531652669587843,0,FALSE +"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.35777,-0.891,0.568,1162,0.865,"carmofur, trifluridine, raltitrexed",0.245651664288981,0.0629838925351858,FALSE +"HCC44","Pearson.est","topoisomerase inhibitor",0.21964,0.572,0.943,212,1,"dexrazoxane, mitoxantrone, licochalcone.a, etoposide",0.0254883072626717,0,FALSE +"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.18012,-0.455,0.988,1157,0.99,"albendazole, BNC105, verubulin, vinblastine, fosbretabulin",0.00524305541237188,0.00436480540245009,FALSE +"HCC44","Pearson.est","tyrosine kinase inhibitor",0.24228,0.625,0.899,134,1,"rheochrysidin, tyrphostin.A9, regorafenib",0.0462403082667712,0,FALSE +"HCC44","Pearson.est","VEGFR inhibitor",0.40815,1.04,0.393,295,0.996,"AEE788, lenvatinib, regorafenib, pazopanib, ZM.306416, telatinib, SAR131675, dovitinib, foretinib, TG.100572, orantinib, nintedanib, cediranib",0.405607449624573,0.00174066157630127,FALSE +"HCC44","Pearson.est","vitamin D receptor agonist",0.41803,1.05,0.383,267,1,"doxercalciferol, maxacalcitol, paricalcitol",0.416801226031377,0,FALSE +"A549","Pearson.est","EGFR inhibitor",-0.18472,-0.499,0.982,1189,1,"CNX.2006, CGP.52411, BIBU.1361, CP.724714, lapatinib, PD.168393, salvianolic.acid.B, WZ8040, WZ.4002",0.00788851221305034,0,FALSE +"A549","Pearson.est","Abl kinase inhibitor",-0.27754,-0.766,0.708,1399,0.865,"nilotinib, KW.2449",0.149966742310231,0.0629838925351858,FALSE +"A549","Pearson.est","acetylcholine receptor agonist",0.35199,0.907,0.544,455,0.896,"nefiracetam, xanomeline, pilocarpine",0.26440110030182,0.0476919903378748,FALSE +"A549","Pearson.est","acetylcholine receptor antagonist",0.73994,1.89,0.0136,381,0.323,"iododexetimide, methscopolamine, diphemanil, darifenacin, hyoscyamine, dicycloverine",1.86646109162978,0.490797477668897,FALSE +"A549","Pearson.est","adenosine receptor antagonist",0.30053,0.758,0.751,264,1,"CGS.15943, MRS.1220",0.124360062995832,0,FALSE +"A549","Pearson.est","adrenergic receptor agonist",0.49291,1.23,0.241,466,0.968,"methyldopa, ritodrine, xylazine, clenbuterol, midodrine, metaraminol, terbutaline, oxymetazoline, A61603",0.617982957425132,0.0141246426916063,FALSE +"A549","Pearson.est","adrenergic receptor antagonist",0.37796,0.956,0.495,354,0.911,"idazoxan, metoprolol, atenolol...., prazosin, oxprenolol, propranolol, RS.17053",0.305394801066431,0.0404816230270017,FALSE +"A549","Pearson.est","AKT inhibitor",-0.32016,-0.864,0.602,1196,0.795,"AZD5363, A.674563, AT7867",0.220403508742175,0.0996328713435297,FALSE +"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.45548,1.17,0.285,440,0.874,"lorlatinib, CEP.37440, GW.788388, NVP.TAE684, DMH1, SB.505124, AP26113",0.54515513999149,0.058488567365597,FALSE +"A549","Pearson.est","androgen receptor antagonist",0.4047,1.01,0.435,487,0.923,"enzalutamide, cyproterone.acetate, bicalutamide, flutamide",0.361510743045363,0.0347982989740879,FALSE +"A549","Pearson.est","antioxidant",-0.46539,-1.24,0.21,1135,0.876,"trolox, mesna, chlorogenic.acid, rutin",0.677780705266081,0.0574958938319193,FALSE +"A549","Pearson.est","AP inhibitor",0.18863,0.473,0.978,1176,1,"tanshinone.i, embelin, LCL.161, GDC.0152, birinapant, idronoxil",0.00966114521239857,0,FALSE +"A549","Pearson.est","ATPase inhibitor",0.40472,1.02,0.415,85,0.938,"k.strophanthidin, evodiamine",0.381951903287907,0.0277971616209356,FALSE +"A549","Pearson.est","Aurora kinase inhibitor",-0.41061,-1.1,0.309,1201,0.689,"MK.5108, MLN.8054, GSK1070916, hesperadin, AMG900, CYC116, KW.2449, PF.03814735",0.510041520575165,0.161780778092374,FALSE +"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.46725,1.21,0.215,158,0.824,"josamycin, azithromycin, tilmicosin, dirithromycin",0.667561540084395,0.0840727883028842,FALSE +"A549","Pearson.est","bacterial DNA gyrase inhibitor",0.48928,1.23,0.221,183,0.968,"norfloxacin, sarafloxacin, sparfloxacin",0.655607726314889,0.0141246426916063,FALSE +"A549","Pearson.est","BCL inhibitor",-0.28603,-0.773,0.724,1238,0.887,"venetoclax, TW.37",0.140261433802853,0.0520763801682736,FALSE +"A549","Pearson.est","Bcr.Abl kinase inhibitor",0.37369,0.956,0.491,318,0.911,"bafetinib, flumatinib, bosutinib, GZD824",0.308918507877032,0.0404816230270017,FALSE +"A549","Pearson.est","benzodiazepine receptor agonist",0.36781,0.954,0.502,77,0.884,"CL.218872, indiplon, gamma.aminobutyric.acid",0.299296282854981,0.0535477349869269,FALSE +"A549","Pearson.est","bromodomain inhibitor",0.4277,1.07,0.383,370,0.991,"I.BET151, JQ1....",0.416801226031377,0.00392634551472468,FALSE +"A549","Pearson.est","calcium channel blocker",0.33841,0.859,0.636,210,0.907,"SKF.96365, fendiline",0.196542884351586,0.0423927129399047,FALSE +"A549","Pearson.est","CC chemokine receptor antagonist",0.37094,0.956,0.504,203,0.911,"SB.225002, PF.04136309",0.297569463554475,0.0404816230270017,FALSE +"A549","Pearson.est","CDK inhibitor",-0.43776,-1.19,0.251,1110,0.737,"palbociclib, ribociclib, PHA.848125, R547, AZD5438, PHA.793887, NU6027, BMS.265246",0.600326278518962,0.132532512140949,FALSE +"A549","Pearson.est","CHK inhibitor",0.30023,0.766,0.751,127,1,"PF.477736",0.124360062995832,0,FALSE +"A549","Pearson.est","cyclooxygenase inhibitor",0.32177,0.809,0.688,100,0.972,"naproxen, pterostilbene, phenylbutazone",0.162411561764489,0.0123337350737254,FALSE +"A549","Pearson.est","cytochrome P450 inhibitor",0.67378,1.73,0.0298,199,0.556,"itraconazole, morin, clotrimazole",1.52578373592374,0.254925208417942,FALSE +"A549","Pearson.est","DNA alkylating agent",-0.44123,-1.22,0.22,1270,0.828,"carmustine, dianhydrogalactitol, cyclophosphamide, carboplatin, mitomycin.c, streptozotocin",0.657577319177794,0.0819696632151199,FALSE +"A549","Pearson.est","DNA inhibitor",-0.37385,-1.01,0.413,1205,0.783,"mechlorethamine, carmustine, nimorazole, teroxirone, carboplatin, valrubicin",0.384049948343599,0.106238237942057,FALSE +"A549","Pearson.est","DNA methyltransferase inhibitor",0.4426,1.12,0.333,6,0.911,"SGI.1027",0.47755576649368,0.0404816230270017,FALSE +"A549","Pearson.est","DNA polymerase inhibitor",0.423,1.06,0.396,618,0.923,"famciclovir, cephalomannine, foscarnet, menadione, trifluridine, cidofovir",0.402304814074488,0.0347982989740879,FALSE +"A549","Pearson.est","DNA synthesis inhibitor",-0.52448,-1.41,0.128,1310,0.68,"enocitabine, cyclocytidine, anisomycin, floxuridine, mitomycin.c",0.892790030352132,0.167491087293764,FALSE +"A549","Pearson.est","dopamine receptor antagonist",0.33172,0.871,0.612,272,0.939,"sertindole, clebopride, nemonapride, domperidone, lurasidone",0.213248577854439,0.0273344077338891,FALSE +"A549","Pearson.est","estrogen receptor agonist",-0.42084,-1.14,0.303,1087,0.714,"ethinyl.estradiol, estradiol, levonorgestrel, PPT",0.518557371497695,0.146301788223826,FALSE +"A549","Pearson.est","estrogen receptor antagonist",0.56015,1.43,0.11,279,1,"toremifene, tamoxifen, fulvestrant",0.958607314841775,0,FALSE +"A549","Pearson.est","FGFR inhibitor",0.53877,1.37,0.136,541,1,"orantinib, erdafitinib, lenvatinib, lucitanib, dovitinib, regorafenib, PD.173074",0.866461091629782,0,FALSE +"A549","Pearson.est","FLT3 inhibitor",0.23949,0.614,0.905,379,0.985,"gilteritinib, tyrphostin.AG.1296, sorafenib, tandutinib, dovitinib",0.0433514207947967,0.00656376950238827,FALSE +"A549","Pearson.est","glucocorticoid receptor agonist",-0.606,-1.65,0.0366,1177,0.547,"triamcinolone, fluticasone.propionate, prednisolone.acetate, flumethasone.pivalate, prednisolone.hemisuccinate, halobetasol.propionate, rimexolone, clobetasol.propionate, dexamethasone.acetate, methylprednisolone, beclomethasone.dipropionate, fludroxycortide, desonide, ciclesonide, prednisolone, fluocinolone.acetonide",1.43651891460559,0.262012673666569,FALSE +"A549","Pearson.est","glutamate receptor antagonist",0.341,0.867,0.6,619,0.919,"kynurenic.acid, JNJ.16259685, felbamate, diazooxonorleucine, IEM1754, LY456236, CPP, CGP.37849, tiletamine, ACDPP",0.221848749616356,0.0366844886138887,FALSE +"A549","Pearson.est","glycogen synthase kinase inhibitor",0.18687,0.477,0.987,485,1,"CHIR.99021, GSK.3.inhibitor.IX, CHIR.98014",0.00568284733036327,0,FALSE +"A549","Pearson.est","growth factor receptor inhibitor",-0.40315,-1.1,0.317,1174,0.689,"PHA.848125, AZD3463",0.498940737782249,0.161780778092374,FALSE +"A549","Pearson.est","HCV inhibitor",-0.33687,-0.884,0.553,1432,0.792,"narlaprevir",0.257274868695302,0.101274818410506,FALSE +"A549","Pearson.est","HDAC inhibitor",-0.34015,-0.945,0.521,1069,0.786,"trichostatin.a, RG2833, PCI.24781, chidamide, mocetinostat, romidepsin, entinostat, JNJ.26481585, givinostat",0.283162276700476,0.104577453960592,FALSE +"A549","Pearson.est","histamine receptor antagonist",0.40639,1.04,0.4,397,0.93,"chloropyramine, famotidine, lafutidine, ebastine, astemizole, tiotidine, epinastine, cyproheptadine",0.397940008672038,0.0315170514460649,FALSE +"A549","Pearson.est","HMGCR inhibitor",-0.2362,-0.648,0.896,1114,0.965,"fluvastatin, pitavastatin",0.0476919903378748,0.0154726866562074,FALSE +"A549","Pearson.est","HSP inhibitor",-0.44121,-1.21,0.238,1146,0.767,"SNX.2112, alvespimycin, BIIB021, NVP.AUY922, PU.H71, VER.49009, ganetespib, tanespimycin",0.623423042943488,0.115204636051019,FALSE +"A549","Pearson.est","JAK inhibitor",-0.31417,-0.838,0.648,1165,0.807,"TG.101209, pacritinib, WHI.P154, filgotinib, AZ960",0.188424994129407,0.0931264652779296,FALSE +"A549","Pearson.est","KIT inhibitor",0.41322,1.06,0.374,282,0.923,"cediranib, lenvatinib, pazopanib, sorafenib, tandutinib",0.42712839779952,0.0347982989740879,FALSE +"A549","Pearson.est","MDM inhibitor",-0.7901,-2.13,0.00233,1438,0.0585,"idasanutlin, RITA",2.63264407897398,1.23284413391782,TRUE +"A549","Pearson.est","MEK inhibitor",-0.51882,-1.35,0.16,1152,0.706,"PD.0325901, PD.198306, MEK162, trametinib, U.0126, nobiletin, TAK.733, AS.703026, Ro.4987655, selumetinib, AZD8330, PD.318088, refametinib, PD.184352",0.795880017344075,0.151195298948196,FALSE +"A549","Pearson.est","MET inhibitor",-0.35853,-0.969,0.451,517,0.822,"AMG458, INC.280, NVP.BVU972, LY2801653, PHA.665752, PF.04217903",0.345823458122039,0.0851281824599496,FALSE +"A549","Pearson.est","microtubule inhibitor",0.18599,0.47,0.986,580,0.987,"colchicine, estramustine.phosphate, triclabendazole, vinflunine",0.0061230850587888,0.00568284733036327,FALSE +"A549","Pearson.est","mTOR inhibitor",-0.73049,-2,0.00796,1223,0.0941,"AZD2014, PI.103, WYE.354, LY3023414, XL388, AZD8055, PP242, temsirolimus, ku.0063794, deforolimus, MLN0128, torin.1, GDC.0980, GSK2126458, sirolimus, everolimus, NVP.BEZ235, SB.2343",2.09908693226233,1.02641037657274,TRUE +"A549","Pearson.est","NFkB pathway inhibitor",0.60624,1.51,0.0748,214,1,"parthenolide...., bindarit, tyloxapol, bortezomib",1.12609840213554,0,FALSE +"A549","Pearson.est","opioid receptor agonist",0.36449,0.907,0.574,461,0.896,"spiradoline, ADL5859, trimebutine",0.241088107602027,0.0476919903378748,FALSE +"A549","Pearson.est","p38 MAPK inhibitor",0.58478,1.5,0.0855,291,1,"TAK.715, SB.239063, SB.242235",1.06803388527183,0,FALSE +"A549","Pearson.est","PARP inhibitor",0.36947,0.933,0.551,339,0.899,"E7449, PJ.34, AG.14361",0.258848401148215,0.0462403082667712,FALSE +"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.24621,0.624,0.903,282,1,"orantinib, lenvatinib, pazopanib, sorafenib, tandutinib",0.0443122496864942,0,FALSE +"A549","Pearson.est","phosphatase inhibitor",0.30736,0.756,0.756,413,0.987,"BVT.948, AS.1949490, alexidine, GSK2830371, CID.5458317",0.121478204498793,0.00568284733036327,FALSE +"A549","Pearson.est","phosphodiesterase inhibitor",0.27832,0.711,0.807,45,0.98,"enoximone",0.0931264652779296,0.00877392430750515,FALSE +"A549","Pearson.est","PI3K inhibitor",-0.5417,-1.49,0.1,1241,0.625,"PI.103, pilaralisib, LY3023414, GDC.0941, taselisib, ZSTK.474, YM.201636, PI3K.IN.2, GDC.0980, GSK2126458, NVP.BEZ235, SB.2343",1,0.204119982655925,FALSE +"A549","Pearson.est","PLK inhibitor",-0.59319,-1.6,0.0588,894,0.508,"GSK461364, NMS.1286937, volasertib, rigosertib, HMN.214",1.23062267392386,0.294136287716081,FALSE +"A549","Pearson.est","potassium channel blocker",0.4789,1.22,0.248,8,0.922,"dofetilide",0.605548319173784,0.0352690789463706,FALSE +"A549","Pearson.est","PPAR receptor agonist",0.38852,0.971,0.481,130,0.981,"pterostilbene, S26948",0.317854923626168,0.0083309926200515,FALSE +"A549","Pearson.est","progesterone receptor agonist",-0.17373,-0.485,0.995,250,0.986,"norethindrone.acetate, nomegestrol.acetate, norethindrone, dienogest, norgestrel, melengestrol.acetate, danazol, tanaproget, levonorgestrel",0.00217691925427455,0.0061230850587888,FALSE +"A549","Pearson.est","proteasome inhibitor",0.55627,1.41,0.118,270,1,"oprozomib, bortezomib, carfilzomib, MG.132",0.928117992693875,0,FALSE +"A549","Pearson.est","protein synthesis inhibitor",-0.25549,-0.687,0.828,1235,0.949,"anguidine, cycloheximide, thiostrepton, mercaptopurine",0.0819696632151199,0.0227337875727074,FALSE +"A549","Pearson.est","protein tyrosine kinase inhibitor",-0.22546,-0.607,0.919,983,0.977,"AV.412, BMS.599626, NVP.TAE226, CP.724714, mubritinib",0.0366844886138887,0.0101054362812269,FALSE +"A549","Pearson.est","RAF inhibitor",0.49439,1.25,0.218,591,1,"GDC.0879, SB.590885, sorafenib, vemurafenib, PLX.4720, regorafenib, RAF265, TAK.632, AZ.628",0.661543506395395,0,FALSE +"A549","Pearson.est","RET tyrosine kinase inhibitor",0.51595,1.31,0.179,468,1,"apatinib, sorafenib, regorafenib",0.747146969020107,0,FALSE +"A549","Pearson.est","retinoid receptor agonist",0.28966,0.729,0.775,345,1,"tamibarotene, adapalene, fenretinide, AM.580",0.11069829749369,0,FALSE +"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.33498,-0.888,0.57,1092,0.82,"triapine, cladribine, gemcitabine, fludarabine, clofarabine",0.244125144327509,0.0861861476162833,FALSE +"A549","Pearson.est","serotonin receptor agonist",-0.43689,-1.18,0.239,630,0.693,"pardoprunox, NAN.190, SR.57227A, zolmitriptan, ipsapirone, aripiprazole",0.621602099051862,0.159266765388193,FALSE +"A549","Pearson.est","serotonin receptor antagonist",0.49588,1.26,0.205,272,1,"lerisetron, sertindole, pirenperone, tropisetron, lurasidone",0.688246138944246,0,FALSE +"A549","Pearson.est","sodium channel blocker",0.4614,1.16,0.277,459,0.851,"cibenzoline, lappaconite, triamterene, benzethonium, oxcarbazepine, quinidine, brivaracetam, mepivacaine, A.803467",0.557520230935551,0.0700704399154121,FALSE +"A549","Pearson.est","src inhibitor",0.22815,0.563,0.951,564,1,"bosutinib, PP.1, saracatinib, ZM.306416",0.0218194830625861,0,FALSE +"A549","Pearson.est","sterol demethylase inhibitor",0.29002,0.723,0.811,254,0.987,"chlormidazole, terconazole",0.090979145788844,0.00568284733036327,FALSE +"A549","Pearson.est","TGF beta receptor inhibitor",0.45853,1.21,0.231,475,0.824,"LY2109761, D.4476, SB.525334, repsox",0.636388020107856,0.0840727883028842,FALSE +"A549","Pearson.est","thymidylate synthase inhibitor",-0.35595,-0.953,0.466,1290,0.81,"raltitrexed, carmofur",0.33161408331,0.0915149811213502,FALSE +"A549","Pearson.est","topoisomerase inhibitor",-0.39816,-1.07,0.349,1392,0.705,"mitoxantrone, idarubicin, voreloxin, valrubicin, amsacrine, TAS.103",0.45717457304082,0.151810883008601,FALSE +"A549","Pearson.est","tubulin polymerization inhibitor",0.24805,0.619,0.898,428,1,"indibulin, vinorelbine, vincristine, vindesine, paclitaxel, nocodazole, ABT.751",0.0467236633326956,0,FALSE +"A549","Pearson.est","tyrosine kinase inhibitor",0.26898,0.696,0.831,287,0.979,"rheochrysidin, tivantinib, bafetinib, apatinib, sorafenib, PP.121",0.080398976215889,0.00921730819686218,FALSE +"A549","Pearson.est","VEGFR inhibitor",0.26694,0.674,0.836,271,0.985,"cediranib, orantinib, lenvatinib, pazopanib, SAR131675, lucitanib, sorafenib",0.0777937225609836,0.00656376950238827,FALSE +"A549","Pearson.est","vitamin D receptor agonist",-0.34369,-0.942,0.492,1018,0.754,"alfacalcidol, doxercalciferol, ercalcitriol, tacalcitol",0.30803489723264,0.122628654130226,FALSE +"H1703","Pearson.est","EGFR inhibitor",0.43554,1.13,0.3,290,0.877,"tyrphostin.AG.1478, OSI.420, BIBX.1382, WZ8040, tyrphostin.AG.494, icotinib, BIBU.1361, erlotinib, gefitinib, PD.153035, CGP.52411, dacomitinib, AZD8931, canertinib, CP.724714, pelitinib",0.522878745280338,0.0570004066339595,FALSE +"H1703","Pearson.est","Abl kinase inhibitor",0.32783,0.834,0.618,11,1,"imatinib",0.209011524911184,0,FALSE +"H1703","Pearson.est","acetylcholine receptor agonist",0.29505,0.749,0.746,115,0.954,"nefiracetam",0.127261172527331,0.0204516252959049,FALSE +"H1703","Pearson.est","acetylcholine receptor antagonist",-0.24619,-0.659,0.842,1353,0.923,"iododexetimide",0.0746879085003505,0.0347982989740879,FALSE +"H1703","Pearson.est","adenosine receptor antagonist",0.64329,1.65,0.0287,189,1,"SCH.58261, CGS.15943, MRS.1220, PSB.1115",1.54211810326601,0,FALSE +"H1703","Pearson.est","adrenergic receptor agonist",0.33315,0.858,0.599,187,0.993,"oxymetazoline, lidamidine, clenbuterol",0.222573177610689,0.00305075150461883,FALSE +"H1703","Pearson.est","adrenergic receptor antagonist",0.28868,0.745,0.761,168,0.897,"dronedarone, levobunolol, imiloxan, atenolol....",0.118615343229427,0.0472075569559079,FALSE +"H1703","Pearson.est","AKT inhibitor",0.6034,1.52,0.0716,204,1,"uprosertib, CCT128930, palomid.529, GDC.0068, triciribine, AZD5363",1.14508697769214,0,FALSE +"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.3049,0.778,0.722,373,0.957,"GW.788388, NVP.TAE684, SB.505124, alectinib",0.141462802430361,0.0190880622231565,FALSE +"H1703","Pearson.est","androgen receptor antagonist",-0.35591,-0.985,0.44,1411,0.896,"flutamide",0.356547323513813,0.0476919903378748,FALSE +"H1703","Pearson.est","antioxidant",0.31943,0.815,0.668,507,0.993,"benfotiamine, mesna, taurine, chlorogenic.acid",0.175223537524454,0.00305075150461883,FALSE +"H1703","Pearson.est","AP inhibitor",-0.35767,-0.949,0.486,1425,0.918,"idronoxil",0.313363730737707,0.0371573187987575,FALSE +"H1703","Pearson.est","ATPase inhibitor",-0.38901,-1.03,0.399,932,0.852,"omeprazole, digoxin, evodiamine, digitoxin, digitoxigenin, k.strophanthidin, oligomycin.a",0.399027104313252,0.0695604052332999,FALSE +"H1703","Pearson.est","Aurora kinase inhibitor",0.22973,0.583,0.932,520,0.967,"MLN.8054, barasertib, GSK1070916, ENMD.2076, tozasertib, MK.8745, barasertib.HQPA, KW.2449, PF.03814735",0.0305840876460186,0.0145735259169983,FALSE +"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.32888,-0.886,0.569,1178,0.898,"valnemulin, azithromycin, josamycin",0.244887733604929,0.0467236633326956,FALSE +"H1703","Pearson.est","bacterial DNA gyrase inhibitor",-0.3204,-0.845,0.616,1206,0.849,"norfloxacin, sparfloxacin, lomefloxacin",0.210419287835575,0.0710923097560473,FALSE +"H1703","Pearson.est","BCL inhibitor",0.3378,0.863,0.606,412,1,"oridonin, venetoclax, obatoclax, HA14.1, navitoclax",0.217527375833714,0,FALSE +"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.39158,0.999,0.444,11,0.986,"imatinib",0.35261702988538,0.0061230850587888,FALSE +"H1703","Pearson.est","benzodiazepine receptor agonist",0.39246,1,0.442,441,1,"nefiracetam, lorazepam, gamma.aminobutyric.acid, ivermectin, piperazine, zaleplon, CGS.20625, eprinomectin",0.354577730650908,0,FALSE +"H1703","Pearson.est","bromodomain inhibitor",-0.42262,-1.19,0.217,1416,0.759,"PFI.1",0.66354026615147,0.11975822410452,FALSE +"H1703","Pearson.est","calcium channel blocker",0.35515,0.906,0.572,388,0.986,"cinnarazine, efonidipine.monoethanolate, SKF.96365, pranidipine, SR.33805",0.242603971206976,0.0061230850587888,FALSE +"H1703","Pearson.est","CC chemokine receptor antagonist",-0.31279,-0.838,0.613,1272,0.792,"MK.0812, UNBS.5162",0.212539525481585,0.101274818410506,FALSE +"H1703","Pearson.est","CDK inhibitor",0.42395,1.06,0.381,469,0.96,"indirubin, AZD5438, TG.02, JNJ.7706621, alvocidib, kenpaullone, P276.00, palbociclib, ribociclib, BMS.387032, PHA.793887, AT.7519, indisulam",0.419075024324381,0.0177287669604316,FALSE +"H1703","Pearson.est","CHK inhibitor",0.23442,0.599,0.917,148,0.973,"SCH.900776",0.0376306643299789,0.0118871597316481,FALSE +"H1703","Pearson.est","cyclooxygenase inhibitor",0.28823,0.748,0.769,300,0.934,"tryptanthrin, FR.122047, amfenac, phenylbutazone, aspirin",0.114073660198569,0.0296531237699066,FALSE +"H1703","Pearson.est","cytochrome P450 inhibitor",0.49241,1.27,0.194,18,1,"PF.4981517, itraconazole",0.712198270069774,0,FALSE +"H1703","Pearson.est","DNA alkylating agent",-0.31615,-0.838,0.653,1143,0.792,"streptozotocin, cyclophosphamide, melphalan, mitomycin.c, dianhydrogalactitol",0.185086818724926,0.101274818410506,FALSE +"H1703","Pearson.est","DNA inhibitor",-0.32689,-0.879,0.599,1217,0.868,"bendamustine, melphalan, valrubicin, chlorambucil, teroxirone",0.222573177610689,0.0614802748235081,FALSE +"H1703","Pearson.est","DNA methyltransferase inhibitor",0.47024,1.22,0.237,4,0.975,"azacitidine",0.625251653989896,0.0109953843014632,FALSE +"H1703","Pearson.est","DNA polymerase inhibitor",0.39207,1.02,0.423,59,1,"famciclovir",0.373659632624958,0,FALSE +"H1703","Pearson.est","DNA synthesis inhibitor",-0.33168,-0.902,0.558,1133,0.967,"nelarabine, artemisinin, enocitabine, azodicarbonamide, mitomycin.c, artesunate",0.253365801062421,0.0145735259169983,FALSE +"H1703","Pearson.est","dopamine receptor antagonist",0.47846,1.23,0.23,340,1,"acetophenazine, mesoridazine, domperidone, ziprasidone, UH.232...., remoxipride, oxiperomide, clebopride",0.638272163982407,0,FALSE +"H1703","Pearson.est","estrogen receptor agonist",-0.32986,-0.891,0.559,475,0.937,"PPT, erteberel, estrone, estradiol, ethinyl.estradiol, equol, estradiol.cypionate, levonorgestrel",0.252588192113577,0.0282604091122217,FALSE +"H1703","Pearson.est","estrogen receptor antagonist",-0.6736,-1.82,0.00978,976,0.21,"danazol, raloxifene, fulvestrant, clomifene, toremifene",2.0096611452124,0.677780705266081,TRUE +"H1703","Pearson.est","FGFR inhibitor",-0.29359,-0.772,0.723,1156,0.833,"nintedanib, dovitinib, regorafenib, erdafitinib",0.140861702705469,0.0793549985932124,FALSE +"H1703","Pearson.est","FLT3 inhibitor",0.30493,0.787,0.685,58,0.965,"sunitinib, TG.02, tandutinib",0.164309428507574,0.0154726866562074,FALSE +"H1703","Pearson.est","glucocorticoid receptor agonist",-0.3922,-1.05,0.381,922,0.87,"ciclesonide, desonide, prednisolone.acetate, halcinonide, beclomethasone.dipropionate, halobetasol.propionate, triamcinolone.acetonide, triamcinolone, betamethasone, prednisolone.hemisuccinate, flumethasone.pivalate, methylprednisolone, fluticasone.propionate, fluorometholone, clobetasol.propionate, deflazacort",0.419075024324381,0.0604807473813815,FALSE +"H1703","Pearson.est","glutamate receptor antagonist",0.39964,0.997,0.449,197,0.915,"diazooxonorleucine, latrepirdine, SIB.1757, kynurenic.acid",0.347753658996677,0.0385789059335517,FALSE +"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.46644,1.2,0.249,338,0.9,"indirubin, CHIR.99021, kenpaullone, GSK.3.inhibitor.IX, LY2090314",0.603800652904264,0.0457574905606751,FALSE +"H1703","Pearson.est","growth factor receptor inhibitor",0.27883,0.695,0.818,317,0.946,"GSK1904529A, lestaurtinib",0.087246696328677,0.0241088635982073,FALSE +"H1703","Pearson.est","HCV inhibitor",0.53353,1.38,0.13,104,1,"PSI.7976, daclatasvir",0.886056647693163,0,FALSE +"H1703","Pearson.est","HDAC inhibitor",0.43262,1.11,0.32,511,0.879,"tacedinaline, vorinostat, romidepsin, R306465, pyroxamide, panobinostat, JNJ.26481585, belinostat, resminostat, ACY.1215, RG2833, RGFP966, nexturastat.a, scriptaid, M.344, SB.939",0.494850021680094,0.0560111249262281,FALSE +"H1703","Pearson.est","histamine receptor antagonist",0.35363,0.922,0.55,361,0.984,"levocetirizine, ranitidine, terfenadine, chloropyramine, epinastine, lafutidine",0.259637310505756,0.00700490156865849,FALSE +"H1703","Pearson.est","HMGCR inhibitor",-0.64677,-1.75,0.032,999,0.226,"simvastatin, fluvastatin, atorvastatin, mevastatin, pitavastatin",1.49485002168009,0.645891560852599,TRUE +"H1703","Pearson.est","HSP inhibitor",0.44262,1.16,0.286,655,0.895,"guanidine, KW.2478, PU.H71, SNX.5422, BIIB021, XL888, tanespimycin, NMS.E973, NVP.AUY922, VER.49009",0.543633966870957,0.048176964684088,FALSE +"H1703","Pearson.est","JAK inhibitor",0.31504,0.798,0.694,437,0.97,"TG.02, atiprimod, pacritinib, CEP.33779, lestaurtinib, tozasertib, filgotinib",0.158640529545145,0.0132282657337552,FALSE +"H1703","Pearson.est","KIT inhibitor",0.51925,1.37,0.149,194,1,"imatinib, sunitinib, tandutinib, OSI.930, KI.8751",0.826813731587726,0,FALSE +"H1703","Pearson.est","MDM inhibitor",0.43827,1.13,0.3,274,0.877,"nutlin.3, CGM097",0.522878745280338,0.0570004066339595,FALSE +"H1703","Pearson.est","MEK inhibitor",0.68565,1.74,0.0204,239,1,"trametinib, PD.0325901, AS.703026, cobimetinib, Ro.4987655, MEK162, refametinib, BIX.02188, selumetinib, TAK.733, AZD8330, PD.184352, PD.198306",1.6903698325741,0,FALSE +"H1703","Pearson.est","MET inhibitor",-0.56503,-1.52,0.0766,1021,0.366,"NVP.BVU972, PHA.665752, LY2801653",1.1157712303674,0.436518914605589,FALSE +"H1703","Pearson.est","microtubule inhibitor",-0.40933,-1.11,0.315,1293,0.8,"cabazitaxel, secnidazole, D.64131",0.501689446210399,0.0969100130080564,FALSE +"H1703","Pearson.est","mTOR inhibitor",-0.14807,-0.406,0.995,970,1,"NVP.BEZ235, PKI.179, MLN0128, torin.1, WYE.125132, everolimus, ku.0063794, PF.04691502, WYE.354, deforolimus, SB.2343",0.00217691925427455,0,FALSE +"H1703","Pearson.est","NFkB pathway inhibitor",0.36507,0.94,0.512,529,0.977,"betulinic.acid, bortezomib, bindarit, IKK.2.inhibitor.V, parthenolide...., curcumin, parthenolide, Ro.106.9920",0.290730039024169,0.0101054362812269,FALSE +"H1703","Pearson.est","opioid receptor agonist",0.52838,1.35,0.149,376,1,"salvinorin.a, BW.180C",0.826813731587726,0,FALSE +"H1703","Pearson.est","p38 MAPK inhibitor",0.31039,0.809,0.698,188,0.976,"CMPD.1, skepinone.l",0.156144577376839,0.0105501823333082,FALSE +"H1703","Pearson.est","PARP inhibitor",0.32701,0.832,0.639,322,0.987,"PJ.34, talazoparib, endo.IWR.1",0.1944991418416,0.00568284733036327,FALSE +"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.3435,0.859,0.626,463,1,"imatinib, sunitinib, tandutinib, KI.8751, SU014813, linifanib, orantinib, motesanib, axitinib, crenolanib",0.20342566678957,0,FALSE +"H1703","Pearson.est","phosphatase inhibitor",-0.31427,-0.863,0.612,1074,0.857,"CID.5458317, AS.1949490, bis.maltolato.oxovanadium.IV., GSK2830371",0.213248577854439,0.0670191780768018,FALSE +"H1703","Pearson.est","phosphodiesterase inhibitor",0.24047,0.629,0.899,613,0.965,"cilostamide, anagrelide, zardaverine, avanafil, GSK256066, papaverine",0.0462403082667712,0.0154726866562074,FALSE +"H1703","Pearson.est","PI3K inhibitor",0.25553,0.667,0.872,345,0.942,"CH5132799, alpelisib, CUDC.907, TG100.115, TG.100713, idelalisib, LY303511, PF.05212384, GSK2126458",0.0594835150674328,0.0259490972071227,FALSE +"H1703","Pearson.est","PLK inhibitor",-0.71167,-1.9,0.0214,1240,0.181,"NMS.1286937, volasertib, BI.2536, GSK461364",1.66958622665081,0.742321425130815,TRUE +"H1703","Pearson.est","potassium channel blocker",0.47435,1.23,0.218,571,1,"oleoylethanolamide, meglitinide, ML133, ibutilide",0.661543506395395,0,FALSE +"H1703","Pearson.est","PPAR receptor agonist",0.4737,1.21,0.261,101,0.938,"oleoylethanolamide, S26948",0.583359492661719,0.0277971616209356,FALSE +"H1703","Pearson.est","progesterone receptor agonist",-0.42577,-1.14,0.303,976,0.802,"danazol, norethindrone, melengestrol.acetate, norgestrel, levonorgestrel, nomegestrol.acetate",0.518557371497695,0.0958256317158365,FALSE +"H1703","Pearson.est","proteasome inhibitor",0.28863,0.745,0.742,598,0.897,"ixazomib.citrate, bortezomib, ixazomib, oprozomib, carfilzomib, MG.132",0.129596094720973,0.0472075569559079,FALSE +"H1703","Pearson.est","protein synthesis inhibitor",0.29715,0.754,0.749,172,0.97,"azomycin..2.nitroimidazole., florfenicol, tedizolid.phosphate, brefeldin.a",0.125518182300534,0.0132282657337552,FALSE +"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.44872,-1.19,0.245,1302,0.759,"rheochrysidin, tyrphostin.A9, mubritinib",0.610833915635468,0.11975822410452,FALSE +"H1703","Pearson.est","RAF inhibitor",-0.27007,-0.738,0.776,1200,0.852,"RAF265, TAK.632, regorafenib, LGX818, PLX.4720",0.110138278741812,0.0695604052332999,FALSE +"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.45922,1.18,0.276,251,0.898,"sunitinib, apatinib",0.559090917934782,0.0467236633326956,FALSE +"H1703","Pearson.est","retinoid receptor agonist",-0.4763,-1.3,0.188,1196,0.68,"adapalene, LE.135, AM.580, bexarotene, fenretinide",0.72584215073632,0.167491087293764,FALSE +"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.6148,-1.7,0.0412,1164,0.234,"hydroxyurea, cladribine, gemcitabine, pentostatin, clofarabine, fludarabine",1.38510278396687,0.630784142589857,TRUE +"H1703","Pearson.est","serotonin receptor agonist",0.5751,1.48,0.0995,74,1,"aripiprazole, ipsapirone",1.00217691925427,0,FALSE +"H1703","Pearson.est","serotonin receptor antagonist",0.49259,1.24,0.23,325,1,"aripiprazole, ziprasidone, SB.228357, tropisetron",0.638272163982407,0,FALSE +"H1703","Pearson.est","sodium channel blocker",0.38374,0.997,0.455,305,0.915,"A.803467, brivaracetam, lappaconite, benzethonium, triamterene, ajmaline",0.341988603342888,0.0385789059335517,FALSE +"H1703","Pearson.est","src inhibitor",0.21982,0.565,0.927,346,0.961,"PP.2, PP.1",0.0329202658555029,0.0172766123314547,FALSE +"H1703","Pearson.est","sterol demethylase inhibitor",-0.60822,-1.62,0.0522,990,0.284,"ketoconazole, sulconazole, chlormidazole, posaconazole, lanoconazole",1.28232949699774,0.546681659952962,FALSE +"H1703","Pearson.est","TGF beta receptor inhibitor",0.54178,1.38,0.149,421,1,"LY2109761, D.4476, SB.431542, repsox",0.826813731587726,0,FALSE +"H1703","Pearson.est","thymidylate synthase inhibitor",-0.2871,-0.779,0.734,414,0.855,"carmofur, raltitrexed, capecitabine, ftorafur, trifluridine, doxifluridine",0.134303940083929,0.0680338852718274,FALSE +"H1703","Pearson.est","topoisomerase inhibitor",-0.69392,-1.9,0.00937,1203,0.181,"daunorubicin, voreloxin, exatecan.mesylate, doxorubicin, teniposide, amonafide, etoposide, nemorubicin, TAS.103, valrubicin, idarubicin, epirubicin, licochalcone.a, etoposide.phosphate, amsacrine, mitoxantrone",2.02826040911222,0.742321425130815,TRUE +"H1703","Pearson.est","tubulin polymerization inhibitor",-0.1455,-0.391,1,895,0.998,"vincristine, KX2.391, podophyllotoxin, BNC105, mebendazole, flubendazole, oxibendazole, dolastatin.10, ABT.751, fenbendazole, epothilone.b, CYT.997",0,0.000869458712628891,FALSE +"H1703","Pearson.est","tyrosine kinase inhibitor",0.1923,0.499,0.973,265,0.978,"sunitinib, tivantinib, UNC2250, apatinib, CP.724714",0.0118871597316481,0.00966114521239857,FALSE +"H1703","Pearson.est","VEGFR inhibitor",0.26496,0.673,0.835,459,0.954,"sunitinib, MGCD.265, PD.173074, semaxanib, OSI.930, KI.8751, SU014813, linifanib, ENMD.2076, orantinib, BMS.690514, motesanib, axitinib, XL.647",0.0783135245163979,0.0204516252959049,FALSE +"H1703","Pearson.est","vitamin D receptor agonist",0.35812,0.942,0.508,136,1,"calcitriol, ercalcitriol",0.294136287716081,0,FALSE +"HCC15","Pearson.est","EGFR inhibitor",-0.24065,-0.623,0.89,1259,1,"CNX.2006, rociletinib, CGP.52411, vandetanib, salvianolic.acid.B, erlotinib, PD.168393, GW.583340",0.0506099933550872,0,FALSE +"HCC15","Pearson.est","Abl kinase inhibitor",-0.465,-1.22,0.233,1251,0.893,"KW.2449, ponatinib, metatinib, dasatinib",0.632644078973981,0.0491485411114536,FALSE +"HCC15","Pearson.est","acetylcholine receptor agonist",0.47098,1.15,0.292,634,0.662,"xanomeline, nefiracetam, pilocarpine, tremorine",0.534617148551582,0.1791420105603,FALSE +"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.34189,-0.924,0.55,493,0.969,"methscopolamine, dicycloverine, iododexetimide, darifenacin, hyoscyamine, diphemanil",0.259637310505756,0.0136762229492347,FALSE +"HCC15","Pearson.est","adenosine receptor antagonist",-0.41729,-1.1,0.313,1438,0.843,"theophylline",0.504455662453552,0.0741724253752577,FALSE +"HCC15","Pearson.est","adrenergic receptor agonist",-0.27624,-0.756,0.747,1298,1,"buphenine, A61603, norepinephrine",0.126679398184601,0,FALSE +"HCC15","Pearson.est","adrenergic receptor antagonist",-0.17521,-0.464,0.992,1082,0.991,"naftidrofuryl, idazoxan, practolol, carvedilol, dihydroergocristine, metoprolol",0.00348832784582135,0.00392634551472468,FALSE +"HCC15","Pearson.est","AKT inhibitor",0.65838,1.66,0.0394,116,0.414,"GDC.0068, uprosertib, AZD5363, GSK2110183",1.40450377817443,0.382999658879101,FALSE +"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.52861,1.31,0.171,177,0.5,"SB.505124, alectinib, DMH1, GW.788388",0.767003889607846,0.301029995663981,FALSE +"HCC15","Pearson.est","androgen receptor antagonist",-0.28333,-0.762,0.723,1266,1,"cyproterone.acetate, enzalutamide",0.140861702705469,0,FALSE +"HCC15","Pearson.est","antioxidant",-0.27216,-0.73,0.781,912,1,"chlorogenic.acid, trolox, mesna, taurine, rutin",0.1073489661227,0,FALSE +"HCC15","Pearson.est","AP inhibitor",-0.31105,-0.817,0.673,1346,0.994,"LCL.161",0.171984935776023,0.00261361560268669,FALSE +"HCC15","Pearson.est","ATPase inhibitor",0.56724,1.4,0.139,302,0.432,"k.strophanthidin, thonzonium, digoxin, evodiamine, omeprazole",0.856985199745905,0.364516253185088,FALSE +"HCC15","Pearson.est","Aurora kinase inhibitor",0.3409,0.831,0.677,408,0.834,"aurora.a.inhibitor.i, barasertib, AMG900, tozasertib, CCT137690, SNS.314, ENMD.2076, danusertib, MK.8745, alisertib, barasertib.HQPA",0.169411331314856,0.0788339493622613,FALSE +"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.27313,0.673,0.871,612,0.916,"tilmicosin, tedizolid, azalomycin.b, dirithromycin",0.0599818449923368,0.0381045263321496,FALSE +"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.4307,1.07,0.374,500,0.723,"norfloxacin, sarafloxacin, lomefloxacin, trovafloxacin",0.42712839779952,0.140861702705469,FALSE +"HCC15","Pearson.est","BCL inhibitor",0.36202,0.895,0.583,382,0.824,"oridonin, gossypol, HA14.1",0.234331445240986,0.0840727883028842,FALSE +"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",-0.43676,-1.17,0.253,1261,0.798,"ponatinib, metatinib, dasatinib",0.596879478824182,0.0979971086492706,FALSE +"HCC15","Pearson.est","benzodiazepine receptor agonist",0.2289,0.561,0.933,53,0.947,"CL.218872",0.0301183562535,0.0236500209967266,FALSE +"HCC15","Pearson.est","bromodomain inhibitor",0.59308,1.46,0.089,158,0.655,"I.BET151, JQ1...., OTX015",1.05060999335509,0.183758700008217,FALSE +"HCC15","Pearson.est","calcium channel blocker",0.4107,1.01,0.428,443,0.777,"SR.33805, SKF.96365, tetrandrine, cinnarazine, mibefradil, efonidipine.monoethanolate",0.368556230986828,0.109578981199086,FALSE +"HCC15","Pearson.est","CC chemokine receptor antagonist",0.34343,0.839,0.644,267,0.845,"SB.225002, PF.04136309",0.191114132640188,0.0731432910503077,FALSE +"HCC15","Pearson.est","CDK inhibitor",0.32768,0.812,0.67,192,0.818,"JNJ.7706621, AZD5438, TG.02, R547",0.173925197299174,0.087246696328677,FALSE +"HCC15","Pearson.est","CHK inhibitor",0.47496,1.17,0.29,226,0.654,"PF.477736, SB.218078",0.537602002101044,0.184422251675733,FALSE +"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.22944,-0.598,0.909,1321,0.974,"suxibuzone, AM.404, indoprofen",0.0414361167780325,0.0114410431213845,FALSE +"HCC15","Pearson.est","cytochrome P450 inhibitor",0.49837,1.2,0.252,602,0.623,"itraconazole, morin, cobicistat, metyrapone",0.598599459218456,0.20551195334083,FALSE +"HCC15","Pearson.est","DNA alkylating agent",-0.40004,-1.09,0.33,1334,0.812,"streptozotocin, carboplatin, mitomycin.c, dianhydrogalactitol",0.481486060122112,0.0904439707588247,FALSE +"HCC15","Pearson.est","DNA inhibitor",-0.34105,-0.881,0.573,1158,0.978,"bendamustine, valrubicin, nimorazole, teroxirone, mechlorethamine, tirapazamine, carboplatin",0.24184537803261,0.00966114521239857,FALSE +"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.57645,1.4,0.117,40,0.432,"azacitidine, SGI.1027",0.931814138253838,0.364516253185088,FALSE +"HCC15","Pearson.est","DNA polymerase inhibitor",0.58985,1.44,0.0911,358,0.618,"trifluridine, cephalomannine, cidofovir, adefovir.dipivoxil",1.040481623027,0.209011524911184,FALSE +"HCC15","Pearson.est","DNA synthesis inhibitor",-0.48544,-1.33,0.164,1125,0.908,"nelarabine, cisplatin, estramustine.phosphate, floxuridine, mitomycin.c",0.785156151952302,0.0419141514789149,FALSE +"HCC15","Pearson.est","dopamine receptor antagonist",0.40429,0.986,0.464,209,0.794,"raclopride, sertindole, clebopride, ziprasidone, mesoridazine",0.333482019445119,0.100179497572904,FALSE +"HCC15","Pearson.est","estrogen receptor agonist",-0.44764,-1.18,0.274,1145,0.918,"PPT, estradiol.cypionate, levonorgestrel, equol",0.562249437179612,0.0371573187987575,FALSE +"HCC15","Pearson.est","estrogen receptor antagonist",-0.2656,-0.711,0.818,383,0.951,"raloxifene, tamoxifen, toremifene, clomifene, fulvestrant, danazol",0.087246696328677,0.0218194830625861,FALSE +"HCC15","Pearson.est","FGFR inhibitor",0.61909,1.54,0.0564,344,0.519,"lucitanib, nintedanib, lenvatinib, erdafitinib, regorafenib",1.24872089601666,0.284832642151542,FALSE +"HCC15","Pearson.est","FLT3 inhibitor",0.39561,0.948,0.511,400,0.809,"sorafenib, TG.02, tozasertib, tyrphostin.AG.1296, ENMD.2076, gilteritinib, tandutinib",0.291579099865287,0.0920514783877277,FALSE +"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.34629,-0.912,0.543,1115,0.953,"desonide, flumethasone, triamcinolone, fluticasone.propionate, methylprednisolone, rimexolone, beclomethasone.dipropionate, deflazacort, betamethasone, fluorometholone, clobetasol.propionate",0.265200170411153,0.0209070993616736,FALSE +"HCC15","Pearson.est","glutamate receptor antagonist",-0.41426,-1.08,0.357,1306,0.787,"CPP, MTPG, LY456236",0.447331783887807,0.104025267640935,FALSE +"HCC15","Pearson.est","glycogen synthase kinase inhibitor",0.22892,0.58,0.937,88,0.957,"CHIR.99021",0.0282604091122217,0.0190880622231565,FALSE +"HCC15","Pearson.est","growth factor receptor inhibitor",-0.36599,-0.995,0.462,1288,0.891,"PHA.848125, GW.441756",0.335358024443874,0.0501222959631252,FALSE +"HCC15","Pearson.est","HCV inhibitor",0.32878,0.813,0.694,434,0.839,"embelin, narlaprevir, daclatasvir",0.158640529545145,0.0762380391712997,FALSE +"HCC15","Pearson.est","HDAC inhibitor",0.28538,0.708,0.829,343,0.897,"RGFP966, R306465, ACY.1215, pyroxamide, belinostat, nexturastat.a, trichostatin.a, vorinostat",0.0814454694497265,0.0472075569559079,FALSE +"HCC15","Pearson.est","histamine receptor antagonist",-0.20203,-0.538,0.976,1319,0.99,"terfenadine, zolantidine",0.0105501823333082,0.00436480540245009,FALSE +"HCC15","Pearson.est","HMGCR inhibitor",0.49251,1.2,0.257,118,0.623,"lovastatin, atorvastatin",0.590066876668705,0.20551195334083,FALSE +"HCC15","Pearson.est","HSP inhibitor",0.38931,0.956,0.511,333,0.823,"NMS.E973, guanidine, KW.2478, SNX.2112, BIIB021",0.291579099865287,0.0846001647877302,FALSE +"HCC15","Pearson.est","JAK inhibitor",0.2626,0.651,0.874,495,0.918,"atiprimod, TG.02, tozasertib, AZD1480, PRT062070, AT.9283, LY2784544",0.058488567365597,0.0371573187987575,FALSE +"HCC15","Pearson.est","KIT inhibitor",0.47071,1.14,0.324,110,0.649,"sorafenib, cediranib, OSI.930, telatinib",0.489454989793388,0.187755303199631,FALSE +"HCC15","Pearson.est","MDM inhibitor",-0.75498,-1.96,0.00777,1329,0.325,"RITA, AMG.232, idasanutlin",2.10957898119909,0.488116639021126,FALSE +"HCC15","Pearson.est","MEK inhibitor",-0.41137,-1.11,0.307,1101,0.878,"trametinib, PD.198306, AS.703026, PD.184352, PD.98059, nobiletin, arctigenin, U.0126, selumetinib",0.512861624522813,0.0565054840938974,FALSE +"HCC15","Pearson.est","MET inhibitor",-0.44758,-1.17,0.266,1151,0.798,"NVP.BVU972, LY2801653, PF.04217903, PHA.665752",0.575118363368933,0.0979971086492706,FALSE +"HCC15","Pearson.est","microtubule inhibitor",0.57105,1.4,0.119,300,0.432,"vinblastine, vinflunine, podophyllotoxin, cabazitaxel, colchicine",0.924453038607469,0.364516253185088,FALSE +"HCC15","Pearson.est","mTOR inhibitor",-0.51208,-1.34,0.175,1093,1,"PF.04691502, LY3023414, ku.0063794, torin.1, AZD2014, WYE.125132, PI.103, sirolimus, temsirolimus, everolimus, deforolimus, MLN0128, NVP.BEZ235, SB.2343, GDC.0980",0.756961951313706,0,FALSE +"HCC15","Pearson.est","NFkB pathway inhibitor",0.58165,1.42,0.104,365,0.528,"parthenolide...., IKK.2.inhibitor.V, bortezomib, betulinic.acid, curcumin, Ro.106.9920",0.98296666070122,0.277366077466188,FALSE +"HCC15","Pearson.est","opioid receptor agonist",0.37624,0.921,0.543,307,0.805,"trimebutine, salvinorin.a",0.265200170411153,0.0942041196321315,FALSE +"HCC15","Pearson.est","p38 MAPK inhibitor",0.70441,1.72,0.0194,375,0.41,"TAK.715, skepinone.l, CMPD.1, SB.239063",1.71219827006977,0.387216143280265,FALSE +"HCC15","Pearson.est","PARP inhibitor",-0.22702,-0.6,0.935,1366,1,"endo.IWR.1",0.0291883891274822,0,FALSE +"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.37938,0.924,0.569,242,0.827,"sorafenib, telatinib, nintedanib, crenolanib, CP.673451, lenvatinib",0.244887733604929,0.0824944904474534,FALSE +"HCC15","Pearson.est","phosphatase inhibitor",0.50959,1.24,0.247,175,0.612,"alexidine, CID.5458317, mycophenolic.acid",0.607303046740334,0.213248577854439,FALSE +"HCC15","Pearson.est","phosphodiesterase inhibitor",-0.40031,-1.06,0.319,1274,0.791,"YM.976, trequinsin",0.496209316942819,0.101823516502323,FALSE +"HCC15","Pearson.est","PI3K inhibitor",-0.30779,-0.824,0.663,1413,1,"NVP.BEZ235, SB.2343, GDC.0980, ZSTK.474",0.178486471595227,0,FALSE +"HCC15","Pearson.est","PLK inhibitor",-0.27457,-0.72,0.762,1219,0.997,"BI.2536, GSK461364",0.1180450286604,0.00130484168834428,FALSE +"HCC15","Pearson.est","potassium channel blocker",-0.25562,-0.69,0.836,1091,0.953,"oleoylethanolamide, meglitinide, ibutilide",0.0777937225609836,0.0209070993616736,FALSE +"HCC15","Pearson.est","PPAR receptor agonist",0.29761,0.722,0.822,340,0.902,"S26948, pterostilbene, GW.501516",0.0851281824599496,0.0447934624580583,FALSE +"HCC15","Pearson.est","progesterone receptor agonist",-0.29643,-0.792,0.707,1132,1,"dienogest, danazol, norethindrone.acetate, nomegestrol.acetate, levonorgestrel",0.150580586203101,0,FALSE +"HCC15","Pearson.est","proteasome inhibitor",0.67121,1.65,0.0258,396,0.33,"MG.132, oprozomib, bortezomib, ixazomib.citrate, ixazomib, carfilzomib, delanzomib",1.58838029403677,0.481486060122112,FALSE +"HCC15","Pearson.est","protein synthesis inhibitor",-0.27266,-0.717,0.799,1247,0.971,"clofoctol, clindamycin.phosphate, anguidine, homoharringtonine, mercaptopurine",0.0974532206860086,0.0127807700919951,FALSE +"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.35029,0.879,0.591,298,0.825,"tyrphostin.A9, PP.121",0.228412519118745,0.0835460514500749,FALSE +"HCC15","Pearson.est","RAF inhibitor",0.54358,1.32,0.154,114,0.515,"sorafenib, SB.590885, RAF265",0.812479279163537,0.288192770958809,FALSE +"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.54837,1.35,0.132,109,0.493,"sorafenib, apatinib",0.87942606879415,0.30715308072277,FALSE +"HCC15","Pearson.est","retinoid receptor agonist",-0.47787,-1.23,0.23,1127,0.963,"adarotene, adapalene, AM.580, bexarotene, LE.135",0.638272163982407,0.0163737128754655,FALSE +"HCC15","Pearson.est","ribonucleotide reductase inhibitor",-0.51085,-1.37,0.146,1190,1,"cladribine, hydroxyurea, gemcitabine, fludarabine, clofarabine",0.835647144215563,0,FALSE +"HCC15","Pearson.est","serotonin receptor agonist",-0.4669,-1.25,0.259,1391,1,"NAN.190, aripiprazole",0.586700235918748,0,FALSE +"HCC15","Pearson.est","serotonin receptor antagonist",0.4239,1.03,0.415,198,0.77,"tropisetron, lerisetron, pirenperone, sertindole, ziprasidone",0.381951903287907,0.113509274827518,FALSE +"HCC15","Pearson.est","sodium channel blocker",0.32297,0.796,0.705,133,0.821,"benzocaine, brivaracetam",0.151810883008601,0.0856568428805592,FALSE +"HCC15","Pearson.est","src inhibitor",-0.31133,-0.828,0.653,448,1,"KX2.391, masitinib, bosutinib, ZM.306416, PP.1, PP.2, saracatinib, TG.100572, dasatinib",0.185086818724926,0,FALSE +"HCC15","Pearson.est","sterol demethylase inhibitor",-0.5067,-1.34,0.158,1277,1,"ketoconazole, lanoconazole, terconazole",0.801342913045577,0,FALSE +"HCC15","Pearson.est","TGF beta receptor inhibitor",0.77391,1.91,0.00303,169,0.161,"SB.525334, LY2109761, repsox, D.4476",2.51855737149769,0.79317412396815,TRUE +"HCC15","Pearson.est","thymidylate synthase inhibitor",-0.50765,-1.36,0.162,1339,1,"raltitrexed, carmofur, doxifluridine",0.790484985457369,0,FALSE +"HCC15","Pearson.est","topoisomerase inhibitor",-0.36632,-0.955,0.476,1351,0.94,"nemorubicin, idarubicin, TAS.103, licochalcone.a, mitoxantrone, amsacrine",0.322393047279507,0.0268721464003014,FALSE +"HCC15","Pearson.est","tubulin polymerization inhibitor",0.58658,1.42,0.114,395,0.528,"vinorelbine, albendazole, vindesine, vinblastine, vincristine, indibulin, plinabulin, taltobulin, BNC105, podophyllotoxin, verubulin, flubendazole, docetaxel, paclitaxel, fenbendazole, mebendazole, parbendazole, fosbretabulin, nocodazole",0.943095148663527,0.277366077466188,FALSE +"HCC15","Pearson.est","tyrosine kinase inhibitor",0.35736,0.876,0.61,344,0.806,"sorafenib, tivantinib, apatinib, UNC2250, tyrphostin.A9, PP.121, 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+
+
+ + + + diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_mean_results.csv b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_mean_results.csv new file mode 100644 index 0000000..0f0a36e --- /dev/null +++ b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_mean_results.csv @@ -0,0 +1,187 @@ +"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"KEGG_HOMOLOGOUS_RECOMBINATION",1.17841666666667,1.02459796624054,1.69270604978669e-07,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1299, HCC44, H1703",7.8710831315081e-06 +"KEGG_DNA_REPLICATION",1.04583333333333,1.50930723622904,9.65595059085032e-10,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,6,"H2126, H460, H1299, HCC44, H1703, HCC15",1.79600680989816e-07 +"KEGG_PHENYLALANINE_METABOLISM",1.03175,1.0895522120244,3.30823591007189e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.000601866189109963 +"KEGG_MISMATCH_REPAIR",1.02908333333333,1.44272503890339,3.27271250262981e-09,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H460, HCC44, A549, H1703",2.02908175163048e-07 +"KEGG_BASE_EXCISION_REPAIR",0.97875,0.910034377472532,0.0022274807226118,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.0165724565762318 +"KEGG_PYRIMIDINE_METABOLISM",0.95825,0.732565370958301,0.0676669686243274,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.209767602735415 +"KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.950333333333333,0.240004671671704,0.703990515716859,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.928588215230605 +"KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.949833333333333,0.647419188826379,0.179726431611031,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.402020815583716 +"KEGG_PROTEASOME",0.916416666666667,1.11351151835765,0.00160602193985387,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, A549",0.013234175660308 +"KEGG_O_GLYCAN_BIOSYNTHESIS",0.874166666666667,1.11231501696673,0.00050770044085861,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.00549278614967061 +"KEGG_SELENOAMINO_ACID_METABOLISM",0.82925,0.959435736158593,0.0233769594882975,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0820398955627046 +"KEGG_RNA_POLYMERASE",0.79125,1.13726059418715,0.00398934765303952,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0224854140444045 +"KEGG_ONE_CARBON_POOL_BY_FOLATE",0.785,1.26987823324629,2.05124549958765e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.000423924069914781 +"KEGG_PURINE_METABOLISM",0.765583333333333,0.775127022826034,0.475897605438069,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.763077194926558 +"KEGG_ETHER_LIPID_METABOLISM",0.749666666666667,0.853712250152594,0.156392207965601,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC15",0.368214565589895 +"KEGG_HISTIDINE_METABOLISM",0.743083333333333,1.12997372924678,0.00205260118811087,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0159076592078593 +"KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.731666666666667,0.928047641149108,0.0997277231660025,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.262854388753961 +"KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.726916666666667,0.865756259876388,0.194742609812029,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.416849153017455 +"KEGG_TYPE_I_DIABETES_MELLITUS",0.72075,0.878264831150812,0.899297334398398,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.999300512449779 +"KEGG_ASTHMA",0.715833333333333,1.11789378527278,0.181557787682968,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, A549",0.402020815583716 +"KEGG_CALCIUM_SIGNALING_PATHWAY",0.7085,0.426377660168669,0.998067068747268,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_OOCYTE_MEIOSIS",0.70125,1.01965048601781,0.0201743308210789,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, HCC15",0.0781755319316807 +"KEGG_TASTE_TRANSDUCTION",0.698166666666667,0.875786693969104,0.227509745426037,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.465343379227885 +"KEGG_VIRAL_MYOCARDITIS",0.678916666666667,0.50100035534978,0.976195227702956,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_TYROSINE_METABOLISM",0.66625,0.938210106823335,0.161335270586965,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.375104504114693 +"KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.659083333333333,1.06095809687911,0.039631626553611,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.129324255069678 +"KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.657333333333333,1.31057304144778,0.000218908690253988,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.00271446775914945 +"KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.643416666666667,1.4040944320958,0.000349743579964154,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1648, H460",0.00406576911708329 +"KEGG_SPLICEOSOME",0.63,1.1901313143744,0.00490790979738636,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H460, HCC44, H1703",0.0260820349232532 +"KEGG_ALLOGRAFT_REJECTION",0.629916666666667,1.08854978241139,0.0613083050690075,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, A549",0.193277029539583 +"KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.622083333333333,1.23359271740078,0.00117797683730166,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0104335091303861 +"KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.614916666666667,1.13991231387916,0.0222912613640232,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.0817110048541387 +"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.614916666666667,0.902022017301667,0.320447232993533,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.584344954282325 +"KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.600583333333333,1.14189320136926,0.00487858307889484,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0260820349232532 +"KEGG_RNA_DEGRADATION",0.599166666666667,1.17748930381811,0.00288087918910435,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.017861450972447 +"KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.597416666666667,1.1660939037763,0.0092123194793993,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.0398486377480993 +"KEGG_BETA_ALANINE_METABOLISM",0.5855,1.14213655448502,0.00919398175340353,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0398486377480993 +"KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.58525,0.868972760845188,0.550513000518132,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.821401533473775 +"KEGG_LINOLEIC_ACID_METABOLISM",0.584666666666667,1.17646846987332,0.00688847961096936,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC15",0.0355904779900083 +"KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.57975,1.0318027581947,0.125141087619991,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.310349897297579 +"KEGG_GLUTATHIONE_METABOLISM",0.578583333333333,1.26367512067226,0.00163648408702733,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC15",0.013234175660308 +"KEGG_AUTOIMMUNE_THYROID_DISEASE",0.578083333333333,1.10723065334056,0.0206262111610574,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.0782954137950342 +"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.567583333333333,1.66617283062567,6.16542804497893e-07,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1648, H460, HCC44",2.29353923273216e-05 +"KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.566,0.608545060705525,0.992102701789679,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.565,1.37543712060104,5.05275875334666e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.00072293317547883 +"KEGG_MAPK_SIGNALING_PATHWAY",0.55,0.695266855243366,0.990183545344897,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_CELL_CYCLE",0.54725,1.20601772375036,0.00737679166078348,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0361074539185718 +"KEGG_ABC_TRANSPORTERS",0.545333333333333,0.934682671803483,0.340266858187058,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.6085541886807 +"KEGG_GLYCEROLIPID_METABOLISM",0.542416666666667,0.90692532100432,0.519422800988407,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.798655854466311 +"KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.53425,0.845615120381715,0.726535117270276,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.932769863334967 +"KEGG_APOPTOSIS",0.531333333333333,0.857080704095789,0.746570598950193,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.939765438870278 +"KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.526,0.910660299902319,0.543721275899292,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.821401533473775 +"KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.525916666666667,0.982801881295914,0.252634710542813,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.494632170115402 +"KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.517,0.748066477357096,0.919293136233065,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_REGULATION_OF_AUTOPHAGY",0.51525,0.962336467807766,0.307795259062343,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.572499181855958 +"KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.508,1.22398930476611,0.00844732992819473,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0383220333327859 +"KEGG_SULFUR_METABOLISM",0.503916666666667,1.43964139842553,0.00323329304440707,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1650, HCC44, HCC15",0.0193997582664424 +"KEGG_PYRUVATE_METABOLISM",0.503,1.1945361214524,0.0170638727671102,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0705306741040557 +"KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.497166666666667,0.719836702862447,0.992993154619186,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_ARACHIDONIC_ACID_METABOLISM",0.494833333333333,1.26928482607213,0.00243682634152823,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC15",0.0167870259083056 +"KEGG_LYSINE_DEGRADATION",0.455666666666667,1.08075834767103,0.102109871023973,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.263783833478597 +"KEGG_ARGININE_AND_PROLINE_METABOLISM",0.450583333333333,1.05908824066513,0.216871461342754,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.458387406929003 +"KEGG_RIBOFLAVIN_METABOLISM",0.438,1.29916819542352,0.00357637473268124,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1299",0.0207876781337097 +"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.4375,1.5241159881894,3.29618288228717e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.000102181669350902 +"KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.42975,1.07053454150039,0.14432287065834,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.348624077174692 +"KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.412916666666667,0.956986696813904,0.552017159592591,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.821401533473775 +"KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.392583333333333,1.07797971462895,0.242776373853048,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.480387292943265 +"KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.392083333333333,1.00736374746016,0.516534340228838,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.798655854466311 +"KEGG_GALACTOSE_METABOLISM",0.382333333333333,1.15621823461689,0.0743950791726998,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.219642614700352 +"KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.369333333333333,0.967518412635066,0.62202506242232,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.88318062298131 +"KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.368,1.27398587119324,0.0959905523004081,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1650, A549",0.262562393056999 +"KEGG_SMALL_CELL_LUNG_CANCER",0.3625,0.865672360863876,0.933870619762417,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.361,0.99768477441069,0.519555690271095,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.798655854466311 +"KEGG_ALZHEIMERS_DISEASE",0.360416666666667,0.927286898658793,0.686561731326467,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.924130465463438 +"KEGG_CITRATE_CYCLE_TCA_CYCLE",0.358,1.33540548830002,0.0335335443815908,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.113404350090471 +"KEGG_FATTY_ACID_METABOLISM",0.355,1.02581205083405,0.387362973771825,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.661004707537243 +"KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.34825,0.742362705396517,0.999300512449779,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.347083333333333,0.934868533133095,0.727159302062205,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.932769863334967 +"KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.341916666666667,0.908748936058733,0.88101399080801,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_NITROGEN_METABOLISM",0.335,1.20457272696399,0.035536345952582,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.118031434771076 +"KEGG_CARDIAC_MUSCLE_CONTRACTION",0.334083333333333,0.942384447542348,0.67917774324564,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.924130465463438 +"KEGG_LONG_TERM_DEPRESSION",0.325916666666667,0.818521556147905,0.990581859975474,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.32,1.82286986520008,2.1106929698738e-09,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"H1648, H460, HCC44, A549, HCC15",1.96294446198263e-07 +"KEGG_OLFACTORY_TRANSDUCTION",0.31525,0.868470245996844,0.964401404432903,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_MTOR_SIGNALING_PATHWAY",0.3115,1.10667228457866,0.185842388347715,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.406666873325588 +"KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.309083333333333,0.793703798464496,0.996749115490075,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_JAK_STAT_SIGNALING_PATHWAY",0.30625,0.843936676319002,0.98661083335621,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.30275,1.02380112814941,0.539363245224781,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.821401533473775 +"KEGG_HUNTINGTONS_DISEASE",0.298583333333333,1.04824966303863,0.349386146149359,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.618912601750292 +"KEGG_INSULIN_SIGNALING_PATHWAY",0.295916666666667,0.958802990317836,0.783512539029393,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.958771922759652 +"KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.292666666666667,1.1016761059514,0.232092287064376,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.465343379227885 +"KEGG_WNT_SIGNALING_PATHWAY",0.291416666666667,0.93719227272775,0.868250406632244,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_BUTANOATE_METABOLISM",0.289333333333333,1.14984373114811,0.100336890330813,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.262854388753961 +"KEGG_PARKINSONS_DISEASE",0.28925,1.11339775829746,0.219980396195696,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.459734311150556 +"KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.286833333333333,1.1508898401856,0.0911817114033164,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.253131318224132 +"KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.284,1.06428191753877,0.399416448291906,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.675376903475405 +"KEGG_RETINOL_METABOLISM",0.283583333333333,1.0130498918283,0.501134746761155,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.789924261843855 +"KEGG_TIGHT_JUNCTION",0.279416666666667,0.856684460668871,0.978503721117808,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_N_GLYCAN_BIOSYNTHESIS",0.279083333333333,1.07077325146859,0.364515100332333,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.633643071605738 +"KEGG_PRIMARY_IMMUNODEFICIENCY",0.27525,1.06285559824807,0.335140683722439,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.6052055065279 +"KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.274333333333333,1.29016181742893,0.0892775011125904,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"A549, HCC15",0.251600230408209 +"KEGG_LEISHMANIA_INFECTION",0.25725,1.07313585728081,0.320255317745033,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.584344954282325 +"KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.253916666666667,1.31526502399073,0.00709531772099448,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.035668353948783 +"KEGG_PRION_DISEASES",0.250583333333333,0.97164129729343,0.792958706376644,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.963989015595136 +"KEGG_OXIDATIVE_PHOSPHORYLATION",0.24325,1.10323269819365,0.174363446184086,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.395507329149268 +"KEGG_LONG_TERM_POTENTIATION",0.243,1.00158537964932,0.666015483885738,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.924130465463438 +"KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.23975,1.00041374395343,0.745563608731219,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.939765438870278 +"KEGG_CELL_ADHESION_MOLECULES_CAMS",0.237083333333333,0.878056889680362,0.976677458215597,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_PATHWAYS_IN_CANCER",0.231666666666667,0.833507303052843,0.99481558419435,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_PEROXISOME",0.221666666666667,1.03962058930024,0.480379407031576,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.763680082973274 +"KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.211583333333333,1.36698017930256,0.00101529519119464,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.00944224527811017 +"KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.20975,0.935412512307708,0.895263647419931,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_SPHINGOLIPID_METABOLISM",0.205416666666667,1.00677337508889,0.67737751260145,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.924130465463438 +"KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.197,0.928697132350673,0.94323304466941,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_TYPE_II_DIABETES_MELLITUS",0.196833333333333,1.11246440869183,0.294953618164136,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.554155282611406 +"KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.195583333333333,0.967637277865602,0.777795656358136,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.95807941776565 +"KEGG_STARCH_AND_SUCROSE_METABOLISM",0.1955,0.914801766902137,0.936057504039486,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.193,1.43012866554027,0.0225532897991842,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, A549",0.0817110048541387 +"KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.191,1.29111720473535,0.0177229605145894,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0716624055589921 +"KEGG_TRYPTOPHAN_METABOLISM",0.188916666666667,1.14059382128412,0.194977829637197,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.416849153017455 +"KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.169916666666667,0.828292049760813,0.996792484249936,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.168333333333333,1.3739067279003,0.00235107954118973,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1299",0.0167870259083056 +"KEGG_NON_HOMOLOGOUS_END_JOINING",0.161833333333333,1.47288472876951,0.000828899422244196,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC44, H1703, HCC15",0.00811448908091687 +"KEGG_PROPANOATE_METABOLISM",0.156666666666667,1.36364707066504,0.00254033960423149,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.016875113085252 +"KEGG_FOLATE_BIOSYNTHESIS",0.155,1.40036034323637,0.000531559949968124,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1648",0.00549278614967061 +"KEGG_VEGF_SIGNALING_PATHWAY",0.153333333333333,1.00617921170168,0.752822851568126,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.939765438870278 +"KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.148666666666667,0.962837221523719,0.915293825739356,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_ENDOCYTOSIS",0.146666666666667,1.01680912067054,0.690613627416225,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.924130465463438 +"KEGG_GNRH_SIGNALING_PATHWAY",0.138916666666667,1.01080566051706,0.759439485033165,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.941704961441125 +"KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.137083333333333,1.00319647838418,0.681588329910571,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.924130465463438 +"KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.129166666666667,1.03823625208886,0.614324427628094,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.878956488760196 +"KEGG_TGF_BETA_SIGNALING_PATHWAY",0.128833333333333,0.94452391406593,0.926832110514637,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_P53_SIGNALING_PATHWAY",0.123,1.03048223486076,0.638724963615894,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.900021539640577 +"KEGG_GAP_JUNCTION",0.115,0.932259425462482,0.945043046567905,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_COLORECTAL_CANCER",0.10775,1.04956667465457,0.60015454373743,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.874900537969625 +"KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.104916666666667,1.27172892039526,0.0281564662340232,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0969833836949688 +"KEGG_PPAR_SIGNALING_PATHWAY",0.100666666666667,0.9703464548419,0.903591358900175,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_ACUTE_MYELOID_LEUKEMIA",0.0939166666666666,1.18172873816543,0.134645570324975,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.329527316847966 +"KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.0928333333333333,1.2215119419156,0.0714238160194078,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.217784094747702 +"KEGG_ERBB_SIGNALING_PATHWAY",0.0920833333333333,1.00924971757452,0.752375663603325,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.939765438870278 +"KEGG_PROTEIN_EXPORT",0.0846666666666667,1.36836414168248,0.00275159868338527,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0176481846589538 +"KEGG_FOCAL_ADHESION",0.0765833333333333,0.889728299521655,0.981798663956214,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_GLIOMA",0.0745833333333333,1.01387111054013,0.71213922581833,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.928588215230605 +"KEGG_NOTCH_SIGNALING_PATHWAY",0.06625,1.15986418679869,0.165237088395876,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.379433314094234 +"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.0652499999999999,1.24421849330851,0.0483770790215612,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.155140287896731 +"KEGG_PROSTATE_CANCER",0.0650833333333333,0.992098827402458,0.83561504777035,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.0495833333333333,1.04463977769924,0.613040633244817,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.878956488760196 +"KEGG_BASAL_CELL_CARCINOMA",0.046,1.05109605131544,0.598023073368012,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.874900537969625 +"KEGG_RENAL_CELL_CARCINOMA",0.0423333333333334,1.12430482224943,0.273796515491987,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.519654611035812 +"KEGG_MELANOGENESIS",0.0418333333333333,0.949206446874376,0.934485076805329,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_MELANOMA",0.038,1.05158296262003,0.602082090645763,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.874900537969625 +"KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.0368333333333334,0.972080602095164,0.868846690864909,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.0355833333333333,1.01756460222286,0.698631085118344,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.928181298800086 +"KEGG_BASAL_TRANSCRIPTION_FACTORS",0.01725,1.30623658757794,0.0079845552802157,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.037128182053003 +"KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.0136666666666667,0.961226142471009,0.930447980678764,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_CHRONIC_MYELOID_LEUKEMIA",0.0135,1.09460607277022,0.446921019061143,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.742208120940827 +"KEGG_VIBRIO_CHOLERAE_INFECTION",0.00625000000000001,1.09782173788909,0.3714205172197,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.639668668545038 +"KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.00383333333333334,0.965722417612218,0.858505892522519,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_LYSOSOME",0.00383333333333332,1.20427457102782,0.0887313049103693,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.251600230408209 +"KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.00149999999999991,1.42894662410653,0.00947614990492257,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, HCC15",0.0400582700526272 +"KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.0261666666666667,1.03044719624172,0.66964869629339,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.924130465463438 +"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.0454166666666666,1.21223943467027,0.113400165358479,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.285032848063203 +"KEGG_PANCREATIC_CANCER",-0.0469166666666666,1.08541717646705,0.467025189737185,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.762967432947268 +"KEGG_DILATED_CARDIOMYOPATHY",-0.0538333333333333,0.913750894374226,0.958308320636934,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779 +"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.0665833333333333,1.22793762488412,0.269941085801347,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.517618989268562 +"KEGG_ENDOMETRIAL_CANCER",-0.07325,1.12364909800816,0.259900637390178,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.50355748494347 +"KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.09375,1.02224726816594,0.713914595580519,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.928588215230605 +"KEGG_THYROID_CANCER",-0.11,1.20126630156378,0.0764071889736128,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.222058392954562 +"KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.12625,1.19455142779052,0.0734459642384711,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.219642614700352 +"KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.1325,1.17375988716912,0.0998239690769561,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.262854388753961 +"KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.141333333333333,1.06289042737531,0.469839139209407,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.762967432947268 +"KEGG_ECM_RECEPTOR_INTERACTION",-0.151583333333333,1.08918154913205,0.471727176284601,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.762967432947268 +"KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.162833333333333,1.3948842137242,0.019146091570016,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1648, HCC44",0.0757696389792124 +"KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.168166666666667,1.08230526976898,0.446526121939017,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.742208120940827 +"KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.208666666666667,1.27680882980922,0.00780760920330105,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.037128182053003 +"KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.214833333333333,1.42326786805662,0.022843936840942,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0817110048541387 +"KEGG_ADHERENS_JUNCTION",-0.220166666666667,1.12923174474212,0.232671689613943,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.465343379227885 +"KEGG_OTHER_GLYCAN_DEGRADATION",-0.250416666666667,1.51114931927706,3.55942369903741e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.000601866189109963 +"KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.287583333333333,1.09291091363913,0.229371436831135,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.465343379227885 +"KEGG_AXON_GUIDANCE",-0.321416666666667,1.05206804639359,0.362417574790632,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.633643071605738 +"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.324916666666667,1.43695558597356,6.4587083490176e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.000858085537798053 +"KEGG_STEROID_BIOSYNTHESIS",-0.343583333333333,1.4671866373396,4.01370354133448e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1299, HCC44",0.000622124048906844 +"KEGG_RIBOSOME",-0.447833333333333,1.43659729495735,0.111402195168252,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1650, H460",0.283846689058835 +"KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.546833333333333,1.4700173056083,1.60584663960682e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.000373359343708586 +"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.579583333333333,1.51624005405317,5.56198202689802e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.00014778980814329 +"KEGG_BLADDER_CANCER",-0.590916666666667,1.02982579800781,0.147445602286902,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.351601051607228 diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_results.csv b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_results.csv new file mode 100644 index 0000000..12f3d9f --- /dev/null +++ b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_results.csv @@ -0,0 +1,2233 @@ +"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"H1650","Input","KEGG_ABC_TRANSPORTERS",0.21787,0.634,0.956,3673,1,"ABCG2, ABCA5, ABCB8, ABCC1, TAP2, ABCA12, ABCB9, ABCB11, ABCC6",0.0195421077238999,0,FALSE +"H1650","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.25175,0.731,0.869,4849,1,"TCF7L1, MAP2K1, AKT2, STAT3, JUP, MTOR, TCF7L2, MAPK3, PIK3R3, RUNX1, AKT3, BAD, RAF1, SOS1, CCNA1, GRB2",0.0609802235513335,0,FALSE +"H1650","Input","KEGG_ADHERENS_JUNCTION",0.41444,1.22,0.174,5643,0.972,"TCF7L1, CDH1, SNAI1, CTNND1, ACTB, CSNK2A2, TJP1, ACTN4, RAC1, BAIAP2, SMAD2, NECTIN4, TGFBR2, PARD3, ERBB2, PTPN1, TCF7L2, AFDN, CTNNA1, NECTIN1, EGFR, PTPRJ, MAPK3, PTPRM, ACP1, EP300, SSX2IP, PTPRF, PTPN6, RHOA, NECTIN2, MET, CDC42, IQGAP1, ACTN1",0.7594507517174,0.0123337350737254,FALSE +"H1650","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.2253,-0.81,0.747,17522,0.896,"IRS2, PCK2, PRKCQ, PRKAG1, PRKAA2, PPARGC1A, RXRB, LEPR, IRS1, NFKBIE, CAMKK1, IKBKB",0.126679398184601,0.0476919903378748,FALSE +"H1650","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.31265,0.925,0.569,2867,0.958,"GLS, ABAT, GOT2, GAD1, GPT2, GFPT1",0.244887733604929,0.0186344909214556,FALSE +"H1650","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.25839,-0.961,0.482,14636,0.904,"FXYD4, KCNJ1, KRAS, PIK3CG, ATP1B2, PIK3R1, IGF1, FXYD2, PIK3CD, PRKCG, HSD11B1, IRS2, SGK1, NR3C2, IRS1, SLC9A3R2, INSR",0.31695296176115,0.0438315695246367,FALSE +"H1650","Input","KEGG_ALLOGRAFT_REJECTION",0.40437,1.17,0.231,2640,1,"CD40, IL12A, IL12B",0.636388020107856,0,FALSE +"H1650","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.34113,0.991,0.468,1909,0.984,"PLA2G12A, ACOX1, PLA2G4B",0.329754146925876,0.00700490156865849,FALSE +"H1650","Input","KEGG_ALZHEIMERS_DISEASE",0.29454,0.861,0.688,4938,0.973,"CHP1, NDUFAB1, UQCRC2, CALM3, PPP3R1, PSENEN, CACNA1D, CYCS, PPP3CA, CYC1, CAPN1, UQCRFS1, NAE1, BID, GAPDH, MME, GNAQ, CASP7, NDUFS6, APP, NDUFB8, COX6B1, ADAM10, EIF2AK3, MAPK3, UQCR10, CASP8, NDUFA8, GRIN2A, SDHA, ITPR2, NDUFB1, BAD, NDUFV2, CALML6, COX6C, SDHB, NDUFB3, NDUFB9, CALM1, COX8A, NDUFB6, NDUFB7",0.162411561764489,0.0118871597316481,FALSE +"H1650","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.29986,-1.15,0.236,16497,0.749,"AARS2, MARS2, TARS2, CARS2, PARS2, FARS2, WARS2",0.627087997029893,0.125518182300534,FALSE +"H1650","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.34794,1.01,0.446,6162,0.999,"NAGK, UGP2, PGM1, GPI, GFPT1, GNE, NANP, GALT, GMPPB, GMPPA, HK2, HK1, PMM2, FPGT, HEXA, NPL, UAP1, UXS1, CYB5R3, GFPT2, PGM2",0.350665141287858,0.000434511774017692,FALSE +"H1650","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.3911,1.13,0.265,5709,1,"CHP1, MAP3K5, PPP3R1, MAPK11, TOMM40, CYCS, PPP3CA, BID, RAC1, MAPK13, DERL1, GRIN2A, BCL2L1, BAD, CASP1, MAP2K3, SOD1, GPX1, RAB5A, NEFH, CCS",0.576754126063192,0,FALSE +"H1650","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.25511,0.744,0.861,3229,1,"IFNA5, HSPA2, NFYC, IFI30, HSPA4, TAP2, HSPA1A, TAPBP, HSPA1B, NFYB",0.0649968485463452,0,FALSE +"H1650","Input","KEGG_APOPTOSIS",0.34533,0.992,0.474,4883,0.994,"CHP1, PPP3R1, TRADD, ENDOD1, CYCS, PPP3CA, NGF, CAPN1, MAP3K14, BID, ENDOG, AKT2, CASP7, MYD88, IL1R1, PRKACG, IL1RAP, PRKAR1B, CASP8, PIK3R3, PRKACA, AKT3, BCL2L1, BAD, CFLAR, DFFA, PRKAR2A, EXOG",0.324221658325915,0.00261361560268669,FALSE +"H1650","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.20615,0.605,0.979,2208,0.998,"PTGES, CYP2E1, CYP4F3, PLA2G12A, PLA2G4B, GPX7",0.00921730819686218,0.000869458712628891,FALSE +"H1650","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.23496,-0.911,0.623,17420,0.808,"ARG2, ALDH1B1, NAGS, GLUD2, ALDH2, PRODH, CPS1, ODC1, GLS2, ACY1, MAOA, AMD1",0.20551195334083,0.0925886392254138,FALSE +"H1650","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.39501,1.16,0.236,2136,1,"TCF7L1, ITGA4, DAG1, CACNA1D, CACNG4, ITGA1, DSC2, SLC8A1, ITGA6, ACTB, ITGB8, DSG2, JUP, PKP2, DSP, ACTN4",0.627087997029893,0,FALSE +"H1650","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.27217,-1.02,0.409,16230,0.845,"MIOX, UGT2B7, ALDH1B1, ALDH2, UGDH",0.388276691992658,0.0731432910503077,FALSE +"H1650","Input","KEGG_ASTHMA",-0.29495,-1.07,0.317,13707,0.771,"IL4, IL13, PRG2, IL10, FCER1G, EPX, RNASE3, IL5, TNF",0.498940737782249,0.112945621949043,FALSE +"H1650","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.31921,0.94,0.561,1349,0.978,"IFNA5, CD40",0.251037138743839,0.00966114521239857,FALSE +"H1650","Input","KEGG_AXON_GUIDANCE",0.37843,1.11,0.298,5824,1,"CHP1, NTN1, SEMA3E, SEMA3D, PAK4, PPP3R1, RHOD, PPP3CA, NTN4, PTK2, SEMA5A, NFAT5, SRGAP2, EFNA5, LIMK2, RAC1, SRGAP1, NFATC1, PLXNA2, ROBO3, PLXNB1, SEMA3F, SEMA4F, EFNA1, RASA1, PAK6, NFATC3, MAPK3, SEMA7A, SLIT3, EPHB3, PLXNB2, ROBO1, EPHA1, GNAI1, SEMA6B, ITGB1, EPHB4, RHOA, EPHA2, ABLIM1, MET, UNC5C, CFL2, PAK2, EFNA2, ROCK1, UNC5B, UNC5A, CDC42, SEMA3C, SEMA4B, CFL1, LIMK1, CDK5, NCK2",0.525783735923745,0,FALSE +"H1650","Input","KEGG_BASAL_CELL_CARCINOMA",0.25186,0.73,0.879,3854,0.993,"TCF7L1, WNT9A, GLI3, WNT7B, WNT7A, WNT6, FZD6, TCF7L2, FZD9, FZD2",0.0560111249262281,0.00305075150461883,FALSE +"H1650","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.33366,-1.19,0.212,18005,0.926,"GTF2F2, STON1, GTF2F1, GTF2H1, TBPL1, GTF2H2",0.673664139071249,0.0333890133180656,FALSE +"H1650","Input","KEGG_BASE_EXCISION_REPAIR",0.27924,0.819,0.754,6434,0.986,"XRCC1, POLE4, POLD1, NEIL3, SMUG1, LIG1, POLE, TDG, POLD2, PARP3, APEX2, MBD4, UNG, POLD3, LIG3",0.122628654130226,0.0061230850587888,FALSE +"H1650","Input","KEGG_BETA_ALANINE_METABOLISM",0.38435,1.1,0.312,6187,1,"ABAT, GAD1, SMS, ECHS1, UPB1, SRM, HADHA, DPYD, ALDH3A2, ALDH9A1",0.505845405981557,0,FALSE +"H1650","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.54217,1.56,0.036,5019,0.883,"ACOT4, SCD5, HACD2, ACAA1, TECR, ACOX1, HACD1, ELOVL6, HADHA, ACOT2, YOD1, ACOT1",1.44369749923271,0.0540392964224314,FALSE +"H1650","Input","KEGG_BLADDER_CANCER",0.29146,0.844,0.718,4165,0.977,"E2F1, CDH1, MAP2K1, TYMP, DAPK2, ERBB2, EGF, DAPK1, EGFR, MAPK3, RAF1, CDKN1A",0.1438755557577,0.0101054362812269,FALSE +"H1650","Input","KEGG_BUTANOATE_METABOLISM",0.32002,0.935,0.559,7337,0.971,"ABAT, ACSM1, GAD1, ECHS1, HADHA, OXCT1, ACSM4, HMGCS1, ALDH3A2, PDHA1, ACAT2, AACS, ALDH9A1, PDHB, OXCT2, ALDH5A1, HADH",0.252588192113577,0.0127807700919951,FALSE +"H1650","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.35091,1.02,0.443,4157,1,"CHP1, PPP3R1, MAP2K1, PPP3CA, VAV3, PLCG2, NFAT5, DAPP1, LILRB3, AKT2, MALT1, RAC1, VAV1, NFATC1, NFKBIB, NFATC3, VAV2, MAPK3, PIK3R3, AKT3, RAF1, SOS1",0.35359627377693,0,FALSE +"H1650","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.31627,0.916,0.597,4692,0.954,"ADORA2A, TNNC1, CHP1, CAMK2G, PLCD1, PLCE1, CALM3, GNAS, PPP3R1, CACNA1D, PPP3CA, P2RX2, PLCG2, SLC8A1, PHKB, RYR1, ADRA1B, SPHK2, PHKG2, GNAQ, P2RX5, OXTR, CAMK2D, PRKACG, HTR6, ADCY1, MYLK2, ERBB2, P2RX4, ADCY7, GNA15, PTK2B, ADRB1, EGFR, ADORA2B, PRKACA, GRIN2A, ITPR2, CALML6, PHKG1, TBXA2R, TRPC1, PLCD3, PTAFR, CALM1",0.224025668870631,0.0204516252959049,FALSE +"H1650","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.31587,0.919,0.596,5320,0.965,"TNNC1, UQCRC2, CACNA1D, CACNG4, CYC1, SLC8A1, TNNI3, UQCRFS1, SLC9A1, TPM2, TPM1, COX6B1, UQCR10, CACNA2D2, COX6C, CACNB1, MYL3, COX8A, TNNT2, CACNG1, ATP1B1",0.224753740259764,0.0154726866562074,FALSE +"H1650","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.30497,0.893,0.642,2668,0.949,"ITGA4, GLG1, CDH3, ITGB2, CDH1, PVR, SDC4, NFASC, SDC1, CD226, ITGA6, CD40, ITGB8, F11R, OCLN, CLDN7, CLDN23, CLDN4, SDC2",0.192464971931147,0.0227337875727074,FALSE +"H1650","Input","KEGG_CELL_CYCLE",0.28974,0.842,0.711,8040,0.964,"E2F1, YWHAZ, PLK1, RBL2, E2F4, RAD21, ORC6, YWHAB, CHEK2, CCNE1, SFN, PKMYT1, ANAPC2, SMAD2, CCND3, ANAPC10, CDC23, CHEK1, SMC1B, RBL1, SKP2, RBX1, ANAPC7, CDKN1A, CCNB1, MAD1L1, CDC25A, CDC25B, EP300, CDKN2D, CCNE2, CCNA1, CDC20, CCNA2, HDAC1, CDC6, MCM5, YWHAE, BUB1, MAD2L2, ZBTB17, CUL1, CDC14A, PRKDC, YWHAQ, ESPL1, CDC45, CDK7, WEE2, TGFB3, CDK2, CDC7, MCM6, GADD45A, ORC3, E2F2, SMAD4, TGFB2, BUB1B, CCNB2, MAD2L1, MCM4, CREBBP, CDC14B, TGFB1, DBF4, GADD45B, ORC1, PTTG1, YWHAG, CCNH, CDKN1B, ABL1, YWHAH",0.148130399270234,0.0159229660971692,FALSE +"H1650","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.328,0.96,0.507,4238,0.973,"CCR3, CCR2, CCL5, CCL28, STAT1, BCAR1, GNG13, MAP2K1, VAV3, STAT2, PRKCD, PTK2, RAP1A, GSK3A, PXN, GRK3, AKT2, STAT3, TIAM1, CXCR1, RAC1, VAV1, CCR1, PRKACG, ADCY1, PARD3, NFKBIB, ADCY7, CXCL16, PTK2B, VAV2, MAPK3, PIK3R3, CCR5, PRKACA, CCL17, AKT3, PRKCZ, CCR4, RAF1, GNG10, SOS1, TIAM2",0.294992040666664,0.0118871597316481,FALSE +"H1650","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.21409,-0.783,0.762,17589,0.915,"SHC3, STAT5B, MYC, CDK4, SHC2, RB1, TP53, CDKN2A, GAB2, HDAC2, MECOM, IKBKB",0.1180450286604,0.0385789059335517,FALSE +"H1650","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.44307,-1.66,0.058,15827,0.35,"PER2, BHLHE41, ARNTL, NPAS2",1.23657200643706,0.455931955649724,FALSE +"H1650","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.44968,1.32,0.0991,6590,1,"PC, MDH1, OGDH, ACO2, IDH3B, SDHA, SUCLG1, MDH2, SDHB, IDH2, IDH3A, PDHA1, IDH1, PDHB, SDHC",1.00392634551472,0,FALSE +"H1650","Input","KEGG_COLORECTAL_CANCER",0.26134,0.765,0.841,3976,0.999,"TCF7L1, MAP2K1, CYCS, AKT2, RAC1, SMAD2, TGFBR2, TCF7L2, MAPK3, PIK3R3, AKT3, BAD, RAF1",0.0752040042020878,0.000434511774017692,FALSE +"H1650","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.34221,-1.3,0.146,13893,0.711,"FGA, SERPIND1, F7, CPB2, FGB, F2, SERPING1, F13A1, C6, F5, C4BPA, C7, CR2, MASP1, C1S, THBD, SERPINF2, C4B, PLG, F10, VWF, F2R, C4A, A2M, KLKB1, SERPINA5, MASP2, C3AR1, BDKRB1, C1R, PROS1, CFH, BDKRB2, C2, SERPINE1, PLAT",0.835647144215563,0.148130399270234,FALSE +"H1650","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.27313,0.789,0.798,4360,0.985,"LDHAL6B, GOT2, SMS, ADI1, TAT, AHCYL2, AHCY, CBS, SRM, DNMT1, DNMT3B, ENOPH1",0.0979971086492706,0.00656376950238827,FALSE +"H1650","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.27248,0.793,0.794,3741,0.986,"CCR3, IFNL1, CCR2, IFNL3, CCL5, CSF1R, IL20RB, IFNA5, CCL28, PDGFB, IFNL2, IL6, IFNB1, BMP7, CD40, IL12A, PDGFA, PDGFC, CXCR1, IL9R, CTF1, CCR1, IL1R1, TGFBR2, TNFRSF25, IL12B, OSMR, IL18, PRLR, EGF, CXCL16, IL1RAP, EGFR, ACVR2A, TNFRSF12A, CCR5, TNFRSF18, CCL17",0.100179497572904,0.0061230850587888,FALSE +"H1650","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.3743,1.09,0.316,3310,1,"CCL5, IFNA5, DDX58, IRF3, POLR3H, IL6, IFNB1, PYCARD, POLR3K, NFKBIB, IL18, ADAR",0.500312917381596,0,FALSE +"H1650","Input","KEGG_DILATED_CARDIOMYOPATHY",0.38677,1.13,0.262,5099,1,"TNNC1, ITGA4, DAG1, GNAS, CACNA1D, CACNG4, ITGA1, SLC8A1, ITGA6, ACTB, TNNI3, ITGB8, TPM2, TPM1, PRKACG, ADCY1, ADCY7, ADRB1, PRKACA, CACNA2D2, ITGAV, LMNA, CACNB1, ITGA3, ITGB1, ITGB4, MYL3, ADCY6, TNNT2, CACNG1",0.581698708680255,0,FALSE +"H1650","Input","KEGG_DNA_REPLICATION",0.35107,1.02,0.398,6811,1,"POLE4, POLD1, DNA2, LIG1, POLE, POLA2, RNASEH2A, POLD2, RPA3, RNASEH2C, RPA1, MCM5, RNASEH1, POLD3, RFC2, MCM6, RFC5",0.400116927926312,0,FALSE +"H1650","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.43449,1.27,0.13,5338,1,"ETV7, MAP2K1, NOTCH3, SPIRE1, EGFR, MAPK3, SOS1, ETS2, GRB2, SPIRE2",0.886056647693163,0,FALSE +"H1650","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.23165,-0.869,0.687,16157,0.874,"GSTM3, GSTO1, ALDH3A1, CYP3A4, UGT2B7, MAOB, GSTT2, GSTM1, CYP3A5, MAOA, GSTM2, GSTZ1, GSTA4, GSTP1",0.16304326294045,0.058488567365597,FALSE +"H1650","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.3639,1.07,0.347,3951,1,"UGT2B17, XDH, CDA, TYMP, TK1, UPP1, CES2, UPB1, UCKL1, NAT2, TK2",0.459670525209126,0,FALSE +"H1650","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.31659,0.929,0.584,4794,0.967,"CHAD, ITGA4, DAG1, SDC4, ITGA1, LAMA5, SDC1, ITGA6, ITGB8, COL5A1, LAMA3, SDC2, HSPG2, LAMB2, LAMB1, LAMC2, LAMB3, ITGAV, TNC, ITGA3, ITGB1, COL11A2, ITGB4",0.233587152887601,0.0145735259169983,FALSE +"H1650","Input","KEGG_ENDOCYTOSIS",0.45307,1.31,0.116,5492,1,"CSF1R, HSPA2, STAMBP, SH3GL2, CBLC, RAB22A, VPS28, VPS4A, EHD2, DNM3, EPN3, AGAP1, FGFR2, SH3GLB2, EHD1, EPN1, AP2S1, ITCH, NEDD4L, CHMP4B, CHMP2A, GRK3, AP2A1, CHMP5, DNAJC6, VPS37B, CXCR1, IQSEC2, CHMP3, RAB11FIP4, HSPA1A, ARAP2, PLD2, VPS4B, PARD3, HSPA1B, ASAP3, ACAP1, PARD6B, ASAP2, VTA1, ARFGAP1, PSD4, EGF, WWP1, CLTB, RAB11A, PIP5K1A, ADRB1, EGFR, CHMP6, RUFY1, TFRC, DAB2, EPN2, CCR5, PRKCI, RAB4A, PRKCZ, IQSEC1, SNF8, EPS15, SH3KBP1, NEDD4, CHMP2B, PLD1, PSD, ASAP1, RAB5C, DNM1, USP8, EHD3, LDLRAP1, CHMP4C, EHD4, SH3GLB1, ARFGAP3, GRK5, MET, RAB11FIP5, STAM2, SH3GL1, ARRB1, CDC42, DNM2, RAB5A",0.935542010773082,0,FALSE +"H1650","Input","KEGG_ENDOMETRIAL_CANCER",0.34995,1.01,0.439,4157,0.999,"TCF7L1, CDH1, MAP2K1, AKT2, ERBB2, TCF7L2, EGF, PTEN, CTNNA1, EGFR, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1",0.357535479757879,0.000434511774017692,FALSE +"H1650","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.37836,1.08,0.324,3705,1,"CCL5, ATP6V0D1, MAPK11, ATP6V1C1, PLCG2, NOD1, MAP3K14, TJP1, CXCR1, F11R, RAC1, MAPK13, ATP6V0A1, ADAM10, ATP6V0C, EGFR, ATP6AP1",0.489454989793388,0,FALSE +"H1650","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.33392,0.973,0.535,4165,0.98,"CAMK2G, GAB1, PAK4, CBLC, MAP2K1, PLCG2, PTK2, TGFA, AKT2, MTOR, CAMK2D, ERBB2, EGF, EGFR, PAK6, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1, CDKN1A",0.271646217978772,0.00877392430750515,FALSE +"H1650","Input","KEGG_ETHER_LIPID_METABOLISM",0.38083,1.11,0.302,6715,1,"PLA2G12A, PAFAH1B3, PLA2G4B, LPCAT2, PAFAH1B1, PLD2, LPCAT1, PLA2G7, PLD1, CHPT1, AGPS, PLA2G10, PLA2G4E, LPCAT4, PAFAH1B2, PLPP1",0.519993057042849,0,FALSE +"H1650","Input","KEGG_FATTY_ACID_METABOLISM",0.23978,0.7,0.902,6379,0.99,"ACAA1, ACOX1, ACSL1, ECHS1, HADHA, ACSL3, CPT1A, ECI1, ALDH3A2, ACAT2, ACADVL, HADHB, CPT1B, ALDH9A1, ACAA2, ACOX3",0.0447934624580583,0.00436480540245009,FALSE +"H1650","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.29266,0.859,0.681,4400,0.961,"MAPK11, MAP2K1, VAV3, PRKCD, PLCG2, PLA2G12A, AKT2, PLA2G4B, RAC1, VAV1, MAPK13, VAV2, MAPK3, PIK3R3, AKT3, RAF1, SOS1, PRKCE, MAP2K3",0.166852888087215,0.0172766123314547,FALSE +"H1650","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.34365,1,0.443,5642,1,"VASP, DNM3, MAP2K1, VAV3, PRKCD, PLCG2, AKT2, PLA2G4B, SPHK2, LIMK2, RAC1, VAV1, PLD2, ASAP3, ASAP2, ARPC3, PIP5K1A, VAV2, MAPK3, PIK3R3, AKT3, ARPC5L, RAF1, PRKCE, PLD1, ASAP1, DNM1, SCIN, CFL2, CDC42, DNM2, PLCG1, CFL1, PLA2G4F, LIMK1",0.35359627377693,0,FALSE +"H1650","Input","KEGG_FOCAL_ADHESION",0.3476,1.02,0.427,5345,1,"CHAD, ITGA4, PAK4, ARHGAP35, PDGFB, MYL9, VASP, BCAR1, MAP2K1, ITGA1, VAV3, LAMA5, PTK2, RAP1A, ITGA6, ACTB, PXN, AKT2, PDGFA, FLNB, PDGFC, ITGB8, RAPGEF1, PDGFD, COL5A1, ACTN4, RAC1, VAV1, LAMA3, MYLK2, ERBB2, CCND3, PPP1CB, EGF, PTEN, EGFR, LAMB2, PAK6, VAV2, MAPK3, PIK3R3, AKT3, ARHGAP5, LAMB1, CAV2, MYL5, LAMC2, BAD, RAF1, LAMB3, SOS1, ITGAV, MYL7, TNC, ITGA3, ITGB1, MYL12B, COL11A2, ITGB4, GRB2, RHOA, CAV1, LAMC1, MET, PAK2, ROCK1, CDC42",0.369572124974976,0,FALSE +"H1650","Input","KEGG_FOLATE_BIOSYNTHESIS",0.59623,1.71,0.00758,771,0.58,"ALPP, SPR",2.12033079436795,0.236572006437063,FALSE +"H1650","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.3083,-1.14,0.321,17725,0.707,"PFKFB1, PFKFB3, GMDS, PFKM, SORD, ALDOC, KHK, MTMR6",0.493494967595128,0.150580586203101,FALSE +"H1650","Input","KEGG_GALACTOSE_METABOLISM",0.34964,1.01,0.445,7455,0.999,"B4GALT1, UGP2, PGM1, B4GALT2, GALT, HK2, HK1, AKR1B1, GLB1, PGM2, PFKP, PFKL, GALK1, MGAM",0.351639989019068,0.000434511774017692,FALSE +"H1650","Input","KEGG_GAP_JUNCTION",0.31075,0.913,0.599,6281,0.943,"PDGFB, GNAS, MAP2K1, TJP1, PDGFA, PDGFC, PDGFD, GNAQ, TUBA4A, PRKACG, ADCY1, ADCY7, TUBB8, EGF, ADRB1, EGFR, MAPK3, PRKACA, ITPR2, RAF1, GUCY1B1, SOS1, GJD2, GNAI1, GUCY1A1, ADCY6, GRB2, TUBB6, GUCY1A2, MAPK7, HRAS, MAP3K2, TUBA8, PRKACB, SRC, TUBB4B",0.222573177610689,0.0254883072626717,FALSE +"H1650","Input","KEGG_GLIOMA",0.37403,1.09,0.325,4849,1,"CAMK2G, E2F1, CALM3, PDGFB, MAP2K1, PLCG2, TGFA, AKT2, PDGFA, MTOR, CAMK2D, EGF, PTEN, EGFR, MAPK3, PIK3R3, AKT3, RAF1, SOS1, CDKN1A, CALML6, CALM1, GRB2",0.488116639021126,0,FALSE +"H1650","Input","KEGG_GLUTATHIONE_METABOLISM",-0.23609,-0.857,0.595,16990,0.826,"PGD, GSTT2, GPX3, GSTM1, GPX2, ODC1, RRM1, GSTM2, GSTZ1, GSTA4, GSTP1",0.22548303427145,0.0830199526796178,FALSE +"H1650","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.22898,-0.865,0.69,16976,0.844,"AGPAT1, DGKI, ALDH1B1, MBOAT1, ALDH2, DGAT2, GPAT4, DGKG, AGPAT3, AKR1A1",0.161150909262745,0.073657553374345,FALSE +"H1650","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.25138,0.73,0.864,3291,0.993,"ACHE, CHKA, LCAT, CDS1, PLA2G12A, PLA2G4B, MBOAT7, LPCAT2, PLD2, DGKE, PLA2G15, DGKA, CHKB, ETNK2, LPCAT1",0.0634862575211067,0.00305075150461883,FALSE +"H1650","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.25031,-0.946,0.5,17033,0.841,"MAOB, AMT, SARDH, CTH, MAOA, SHMT2",0.301029995663981,0.0752040042020878,FALSE +"H1650","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.2593,0.753,0.857,6578,1,"ALDH3B2, PGAM1, PGM1, GAPDH, FBP2, GALM, PGAM4, LDHAL6B, ACSS2, GPI, ALDOA, ACSS1, HK2, HK1, ALDH1A3, ALDH3B1, ALDH3A2, PDHA1, ENO1, PGM2, ALDH9A1, PKM, PFKP, PDHB",0.0670191780768018,0,FALSE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.46894,1.36,0.087,4591,1,"CHST14, XYLT1, CHST7, CHST12, B4GALT7, CHPF, DSE, CHST11, CHST15, CSGALNACT1, CHST3",1.06048074738138,0,FALSE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.39462,1.16,0.22,3145,1,"XYLT1, NDST1, EXT2, HS2ST1, B4GALT7, EXT1",0.657577319177794,0,FALSE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.53584,1.55,0.0326,2510,0.775,"CHST6, B4GALT4, B4GALT1, ST3GAL1, B4GALT2, B3GNT2",1.48678239993206,0.11069829749369,FALSE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.35799,1.05,0.38,764,1,"HPSE, GALNS",0.42021640338319,0,FALSE +"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.34124,0.997,0.432,5398,1,"ST6GALNAC5, ST3GAL1, B4GALNT1, B3GALT4, HEXA, GLB1",0.364516253185088,0,FALSE +"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.46931,1.36,0.0786,1325,1,"FUT9, FUT1, ST3GAL1",1.10457745396059,0,FALSE +"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.62171,1.82,0.0043,2766,0.408,"B3GNT3, B4GALT4, B4GALT1, FUT9, FUT1, FUT3, ST3GAL4, B4GALT2, B3GNT2, ABO",2.36653154442041,0.38933983691012,FALSE +"H1650","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.45711,1.32,0.099,4292,1,"GPAA1, PIGQ, PIGT, PIGO, PIGK, PIGG, PIGX, GPLD1, PIGU, PIGV, PIGN, PIGL",1.00436480540245,0,FALSE +"H1650","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.57196,1.67,0.0131,4273,0.567,"MDH1, MTHFD2, ACO2, PGP, GRHPR, MTHFD1L, MDH2",1.88272870434424,0.246416941107093,FALSE +"H1650","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.33254,0.966,0.517,6405,0.966,"CAMK2G, CALM3, GNAS, CACNA1D, MAPK11, MAP2K1, PRKCD, PLA2G12A, PLA2G4B, GNAQ, PLD2, CAMK2D, PRKACG, ADCY1, MAPK13, ADCY7, PTK2B, EGFR, MAPK3, PRKACA, ITPR2, RAF1, SOS1, CALML6, PLD1, MAP2K3, CALM1, ADCY6, GRB2, CDC42, MMP2, MAPK7, CGA, HRAS, PLA2G10, MAP3K2, PRKACB, SRC, PLA2G4E, HBEGF",0.286509456906058,0.0150228735845067,FALSE +"H1650","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.24724,-0.913,0.524,11132,0.843,"IFNG, FASLG, KIR3DL2, IL2, FAS, CD28, KIR3DL1, KIR2DL3, PRF1, KLRD1, GZMB, CD86, TNF, IL1B, IL1A",0.280668713016273,0.0741724253752577,FALSE +"H1650","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.2994,0.873,0.684,3717,0.972,"BMP5, WNT9A, BMP7, GLI3, WNT7B, WNT7A, WNT6, PRKACG, PRKACA, GAS1",0.164943898279884,0.0123337350737254,FALSE +"H1650","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.27752,0.806,0.782,3762,0.978,"CSF1R, ITGA4, ITGA1, IL6, ANPEP, ITGA6, MME, IL9R, IL1R1, CD14, TFRC, CD59, CD9, CD55",0.106793246940152,0.00966114521239857,FALSE +"H1650","Input","KEGG_HISTIDINE_METABOLISM",-0.35664,-1.32,0.129,15605,0.804,"DDC, HAL, AOC1, AMDHD1, ALDH3A1, MAOB, ACY3, ALDH1B1, ALDH2, HNMT, METTL2B, MAOA",0.889410289700751,0.0947439512515487,FALSE +"H1650","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.49845,1.45,0.0595,6516,1,"POLD1, RAD51, XRCC3, POLD2, RPA3, NBN, RPA1, RAD52, EME1, XRCC2, RAD51C, RAD54B, POLD3, BLM",1.22548303427145,0,FALSE +"H1650","Input","KEGG_HUNTINGTONS_DISEASE",0.21549,0.63,0.954,5129,0.998,"DNAI1, NDUFAB1, UQCRC2, POLR2K, CYCS, CYC1, POLR2I, POLR2C, AP2S1, UQCRFS1, DCTN1, DNAL1, AP2A1, DNAL4, GNAQ, NDUFS6, PPARG, NDUFB8, TAF4, TBPL2, TGM2, COX6B1, HAP1, CLTB, UQCR10, CASP8, NDUFA8, HTT, POLR2A, SDHA, NDUFB1, NDUFV2, COX6C, SDHB, EP300, NDUFB3, NDUFB9, SOD1, COX8A, NDUFB6, HDAC1, NDUFB7, TBP, CREB3, VDAC2",0.0204516252959049,0.000869458712628891,FALSE +"H1650","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.37839,1.1,0.314,2500,1,"TNNC1, ITGA4, DAG1, CACNA1D, CACNG4, ITGA1, IL6, SLC8A1, PRKAA1, ITGA6, PRKAG2, ACTB, TNNI3, ITGB8, TPM2, TPM1",0.503070351926785,0,FALSE +"H1650","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.34387,0.99,0.477,5527,0.974,"PLCD1, PLCE1, PLCG2, PIK3C2B, INPP4B, IMPA2, INPP5A, MINPP1, INPP1, ITPK1, PIP4K2C, INPP5E, PTEN, PIP5K1A, SYNJ1, INPP4A, INPPL1, PLCD3, IPPK, PIK3C2G, ISYNA1, CDIPT, PLCG1",0.321481620959886,0.0114410431213845,FALSE +"H1650","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.28638,0.819,0.752,4861,0.986,"CBLC, CALM3, GYS1, MAP2K1, PRKAA1, PPP1R3C, PRKAG2, PHKB, PPP1R3D, AKT2, RAPGEF1, FBP2, SOCS1, MTOR, PHKG2, SH2B2, PRKACG, PTPN1, PPP1CB, PRKAR1B, MAPK3, FLOT2, PIK3R3, PRKACA, AKT3, PRKCI, PRKCZ, BAD, RAF1, SOS1, CALML6, PHKG1, TSC1, HK2, HK1, PTPRF, CALM1, RPTOR, GRB2, PRKAR2A",0.123782159408358,0.0061230850587888,FALSE +"H1650","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.39617,1.15,0.223,1524,1,"ITGA4, CCL28, IL6, CD40, MAP3K14",0.651695136951839,0,FALSE +"H1650","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.30651,0.894,0.635,6363,0.956,"IFNL1, IFNL3, IL20RB, IFNA5, CBLC, STAT1, IFNL2, STAT4, STAT2, IL6, IFNB1, IL12A, AKT2, STAT3, IL9R, SOCS1, CTF1, IRF9, IL12B, CCND3, OSMR, SPRED2, PRLR, PIAS1, PIK3R3, AKT3, BCL2L1, TYK2, IFNLR1, SOS1, EP300, IL11RA, PTPN6, GRB2, JAK1, STAM2, SPRY3, IL3RA, JAK2, PIM1, IFNE, CLCF1, IL22, CSF3R, PIK3CB, IL4R, STAM, IL15",0.197226274708024,0.0195421077238999,FALSE +"H1650","Input","KEGG_LEISHMANIA_INFECTION",0.36569,1.06,0.351,2960,1,"ITGA4, ITGB2, STAT1, FCGR3B, MAPK11, IL12A, NCF4, MYD88, TAB2, IL12B, NFKBIB, MAPK13",0.454692883534176,0,FALSE +"H1650","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.4217,1.24,0.16,5643,0.99,"ITGA4, ARHGAP35, ITGB2, MYL9, CTNND1, VASP, MAPK11, BCAR1, VAV3, RASSF5, PLCG2, PTK2, RAP1A, ACTB, PXN, F11R, OCLN, ACTN4, RAC1, CLDN7, VAV1, NCF4, CLDN23, CLDN4, MAPK13, AFDN, PTK2B, CTNNA1, VAV2, PIK3R3, ARHGAP5, MYL5, MYL7, GNAI1, CLDN9, ITGB1, MYL12B, RHOA, EZR, CLDN8, ESAM, ROCK1, CDC42, MMP2, PLCG1, CLDN1, ACTN1",0.795880017344075,0.00436480540245009,FALSE +"H1650","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.27111,0.78,0.803,6187,0.991,"ECHS1, HADHA, YOD1, ALDH3A2, ALDH9A1",0.095284454721319,0.00392634551472468,FALSE +"H1650","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.2528,0.726,0.869,1909,0.984,"CYP2E1, PLA2G12A, PLA2G4B",0.0609802235513335,0.00700490156865849,FALSE +"H1650","Input","KEGG_LONG_TERM_DEPRESSION",0.23816,0.699,0.904,4678,0.984,"GNAO1, GNAS, PPP2R1A, MAP2K1, PLA2G12A, RYR1, PLA2G4B, GNAQ, MAPK3, ITPR2, RAF1, GUCY1B1, GNAI1, GUCY1A1, GNA12",0.0438315695246367,0.00700490156865849,FALSE +"H1650","Input","KEGG_LONG_TERM_POTENTIATION",0.38026,1.12,0.286,4692,1,"CHP1, CAMK2G, CALM3, PPP3R1, MAP2K1, PPP3CA, RAP1A, RPS6KA1, GNAQ, CAMK2D, PRKACG, ADCY1, PPP1CB, MAPK3, PRKACA, GRIN2A, ITPR2, RAF1, CALML6, EP300, CALM1",0.543633966870957,0,FALSE +"H1650","Input","KEGG_LYSINE_DEGRADATION",0.33936,0.977,0.496,6687,0.992,"BBOX1, OGDH, PLOD2, KMT5A, KMT5C, SETD2, ECHS1, HADHA, PLOD1, AASDHPPT, AADAT, NSD2, KMT5B, ALDH3A2, SETD1A, ACAT2, ALDH9A1, SETD1B, NSD1, PLOD3, TMLHE, EHMT1",0.304518323509803,0.00348832784582135,FALSE +"H1650","Input","KEGG_LYSOSOME",0.32758,0.951,0.537,5502,0.967,"AP1G1, AP3S1, GGA2, CTSV, ATP6V0D1, GALNS, MFSD8, GM2A, AP4E1, MANBA, LAPTM4A, CTSA, ARSA, AP1M2, GNPTAB, DNASE2, ACP2, CTSH, PPT1, ABCB9, PLA2G15, AP1S1, ATP6V0A1, LAMP3, ATP6V0C, CLTB, CTSZ, GALC, ATP6AP1, AP4M1, PPT2, AP1B1, NAGPA, CTSL, CD68, ATP6V0A4, HEXA, GLB1, PSAP, NAGLU, SLC11A1",0.270025714300444,0.0145735259169983,FALSE +"H1650","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.30049,0.868,0.661,4157,0.975,"CHP1, DUSP14, NTF4, HSPA2, STK3, MAP3K5, HSPB1, PDGFB, PPP3R1, CACNA1D, CACNG4, MAPK11, MAP2K1, PPP3CA, FGFR2, TAOK3, RAP1A, PLA2G12A, NGF, MAP3K14, FGF11, FGF2, MAPK8IP2, JUND, AKT2, PDGFA, FLNB, PLA2G4B, MAPKAPK3, RPS6KA1, RAC1, MAP3K6, MAP3K8, ECSIT, HSPA1A, PPP5C, MAP4K2, IL1R1, TGFBR2, TAB2, PRKACG, RPS6KA4, RASGRP4, HSPA1B, RRAS, CD14, MAPK13, NF1, MAP3K20, TAOK2, EGF, NFKB2, MAPK8IP3, EGFR, STK4, RASA1, MAPK3, DUSP9, PRKACA, AKT3, RAF1, CACNA2D2, MAP4K3, RAPGEF2, SOS1",0.17979854051436,0.0109953843014632,FALSE +"H1650","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.50536,-1.93,0,15732,0.188,"HNF4A, BHLHA15, HNF1A, HHEX, ONECUT1, FOXA3, HNF1B, FOXA2, GCK, HNF4G",Inf,0.72584215073632,TRUE +"H1650","Input","KEGG_MELANOGENESIS",0.35633,1.03,0.402,5327,1,"TCF7L1, CAMK2G, GNAO1, CALM3, GNAS, WNT9A, MAP2K1, WNT7B, GNAQ, WNT7A, MITF, WNT6, CAMK2D, PRKACG, ADCY1, FZD6, TCF7L2, ADCY7, FZD9, MAPK3, PRKACA, FZD2, RAF1, CALML6, EP300, GNAI1, CALM1, FZD1, ADCY6, CREB3, KITLG, WNT9B",0.39577394691553,0,FALSE +"H1650","Input","KEGG_MELANOMA",0.33754,0.968,0.5,4165,0.971,"E2F1, CDH1, PDGFB, MAP2K1, FGF11, FGF2, AKT2, PDGFA, PDGFC, PDGFD, MITF, EGF, PTEN, EGFR, MAPK3, PIK3R3, AKT3, BAD, RAF1, CDKN1A",0.301029995663981,0.0127807700919951,FALSE +"H1650","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.25715,-0.946,0.488,16157,0.841,"GSTM3, GSTO1, ALDH3A1, CYP3A4, UGT2B7, GSTT2, GSTM1, CYP3A5, AKR1C2, AKR1C1, AKR1C3, GSTM2, GSTZ1, GSTA4, GSTP1",0.311580177997289,0.0752040042020878,FALSE +"H1650","Input","KEGG_MISMATCH_REPAIR",0.43736,1.28,0.14,6811,1,"POLD1, EXO1, LIG1, PMS2, POLD2, RPA3, RPA1, POLD3, RFC2, RFC5",0.853871964321762,0,FALSE +"H1650","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.27644,0.809,0.779,7014,0.981,"PRKAA1, AKT2, RPS6KA1, MTOR, ULK2, DDIT4, MAPK3, PIK3R3, RICTOR, AKT3, CAB39, ULK1, TSC1, RPTOR, MLST8, RHEB, TSC2, PIK3CB, EIF4E, VEGFB, BRAF, VEGFC",0.108462542327436,0.0083309926200515,FALSE +"H1650","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.34616,1.01,0.45,3669,0.999,"CHP1, IFNA5, RAET1E, HCST, ITGB2, RAET1G, RAET1L, FCGR3B, PPP3R1, MAP2K1, PPP3CA, VAV3, PLCG2, IFNB1, NFAT5, BID, RAC1, VAV1, NFATC1, PTK2B, ULBP2, NFATC3, VAV2, MAPK3, PIK3R3",0.346787486224656,0.000434511774017692,FALSE +"H1650","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.18027,0.523,0.994,5211,0.997,"GRIN3B, ADORA2A, ADRA2A, OPRK1, MLNR, THRB, CHRM4, P2RY2, P2RX2, S1PR5, TRPV1, LPAR2, ADRA1B, HTR1D, ADRA2B, S1PR1, P2RX5, OXTR, HTR6, PARD3, P2RX4, GABRE, PRLR, S1PR2, ADRB1, P2RY13, F2RL1, ADORA2B, GRIN2A, GALR2, VIPR1, GRM4, S1PR3, GABBR2, TBXA2R, GABRB3, PTAFR, GALR3, CHRNA4, P2RY6, NR3C1, GPR156, GLRB, C5AR1",0.00261361560268669,0.00130484168834428,FALSE +"H1650","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.31006,0.9,0.622,4851,0.958,"NTF4, CAMK2G, GAB1, MAP3K5, CALM3, YWHAZ, MAPK11, MAP2K1, PRKCD, PLCG2, RAP1A, YWHAB, NGF, ZNF274, AKT2, RAPGEF1, RPS6KA1, RAC1, TP73, CAMK2D, SH2B2, RPS6KA4, NFKBIB, ARHGDIB, MAPK13, RIPK2, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1, CALML6, CALM1, SH2B1, GRB2, RHOA",0.206209615309181,0.0186344909214556,FALSE +"H1650","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.31926,-1.17,0.198,18057,0.772,"PNP, NAMPT, NMNAT3, NNT, NADSYN1",0.703334809738469,0.112382699664264,FALSE +"H1650","Input","KEGG_NITROGEN_METABOLISM",-0.42922,-1.65,0.0361,15897,0.276,"CA7, HAL, CA3, CA14, AMT, CA8, GLUD2, CTH, CPS1, CA12, GLS2, CA13",1.44249279809434,0.559090917934782,FALSE +"H1650","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.34318,0.993,0.465,4230,1,"CCL5, MAPK11, IL6, NOD1, TAB3, PYCARD, TAB2, NFKBIB, IL18, MAPK13, RIPK2, MAPK3, CASP8, NLRC4, ERBIN, CARD8, CASP1",0.332547047110046,0,FALSE +"H1650","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.23973,0.692,0.915,5915,0.977,"XRCC4, XRCC6, NHEJ1, PRKDC",0.0385789059335517,0.0101054362812269,FALSE +"H1650","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.33667,0.983,0.49,4157,0.985,"E2F1, MAP2K1, RASSF5, PLCG2, TGFA, AKT2, ERBB2, EGF, RXRA, EGFR, STK4, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1",0.309803919971486,0.00656376950238827,FALSE +"H1650","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.36217,1.05,0.36,5177,1,"DTX4, PSENEN, KAT2B, DTX3L, NOTCH3, JAG2, DTX2, NUMBL, KAT2A, CTBP2, LFNG, EP300, HDAC1, DLL3, MAML2, HES5",0.443697499232713,0,FALSE +"H1650","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.33265,0.968,0.51,4716,0.971,"ERCC4, POLE4, POLD1, RAD23A, GTF2H5, LIG1, POLE, ERCC2, ERCC1, RBX1, POLD2, RPA3, ERCC6, CETN2, RAD23B, RPA1",0.292429823902064,0.0127807700919951,FALSE +"H1650","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.30488,0.894,0.64,5036,0.956,"MGAT5B, MAN1B1, B4GALT1, RPN2, MGAT3, DPM1, STT3A, B4GALT2, STT3B, ALG12, MAN2A1, RFT1, MGAT4A, MOGS, DOLPP1, MGAT1, MGAT2, DDOST",0.193820026016113,0.0195421077238999,FALSE +"H1650","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.17232,-0.643,0.953,10204,1,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR6A2, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, ADCY3, OR5B3, OR10G3, OR10H1, OR1D2, OR52M1, OR2A7, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51E1, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR1N1, OR2C1, OR10G4, PDC, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR5AK2, CLCA1, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR4D5, OR5K2, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, CNGA3, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, CAMK2B, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, OR51E2, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR1B1, OR2L3, OR8D1, OR11H6, OR52N4, OR10V1, CLCA4, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5B21, OR5M11, OR13G1, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR52D1, OR51I1, OR52N2, OR8S1, OR2AT4, OR9A2, OR51Q1, OR13D1, ARRB2, OR8D2, OR2T33, OR1J2, OR2A5, OR52H1, CALM2, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, OR2T8, CALML3, OR4D1, OR8G1, OR4F15, OR52B6, OR2A25, GUCY2D, OR1Q1, OR8A1, CALML5, OR2B2, OR1K1, OR4F3, OR11H4, OR51B4, OR13A1, OR10AD1, OR6B2, OR2K2, OR13H1, OR7D2, OR2A14, OR13J1, OR4F16, OR4F17, OR2W3, PDE1C, OR56B4, OR1L8, OR2AE1, OR2H2, PRKX, OR52W1, GUCA1B, PRKG1, PRKG2",0.0209070993616736,0,FALSE +"H1650","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.29854,0.883,0.645,6661,0.956,"MTHFD2, MTHFS, MTHFR, MTHFD1L, SHMT1, DHFR, ATIC, MTHFD2L",0.190440285364732,0.0195421077238999,FALSE +"H1650","Input","KEGG_OOCYTE_MEIOSIS",0.39828,1.14,0.264,5310,1,"CHP1, CAMK2G, CALM3, YWHAZ, PLK1, PPP2R1A, PPP3R1, MAP2K1, PPP3CA, AURKA, YWHAB, PPP2R5E, CCNE1, PKMYT1, RPS6KA1, ANAPC2, SPDYA, CAMK2D, PRKACG, ADCY1, PPP1CB, ANAPC10, ADCY7, CDC23, SMC1B, SGO1, FBXO5, REC8, MAPK3, PRKACA, ITPR2, RBX1, ANAPC7, CCNB1, CALML6, CCNE2, CALM1, CDC20, ADCY6, YWHAE, BUB1, MAD2L2, PPP2CA",0.578396073130169,0,FALSE +"H1650","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.23116,0.676,0.916,5738,0.985,"MANBA, NEU2, MAN2C1, HEXA, GLB1, FUCA2",0.0381045263321496,0.00656376950238827,FALSE +"H1650","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.25352,0.735,0.88,5038,1,"NDUFAB1, UQCRC2, ATP6V0D1, ATP6V1C1, CYC1, UQCRFS1, LHPP, NDUFS6, NDUFB8, COX17, ATP6V0A1, COX6B1, ATP6V0C, COX15, UQCR10, NDUFA8, ATP6AP1, SDHA, NDUFB1, NDUFV2, ATP5MG, COX6C, SDHB, NDUFB3, NDUFB9, COX8A, NDUFB6, ATP6V1B1, NDUFB7, ATP6V0A4",0.0555173278498314,0,FALSE +"H1650","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.46457,1.35,0.0963,5221,1,"C1GALT1, GALNT7, GALNT3, B4GALT5, ST3GAL1, GALNT6, GALNT2, GALNT14, GALNT12, GALNT10, GCNT4, C1GALT1C1, GALNT9, GALNT13, GCNT1",1.01637371287547,0,FALSE +"H1650","Input","KEGG_P53_SIGNALING_PATHWAY",0.36095,1.04,0.393,4216,1,"TP53AIP1, SIAH1, TP53I3, CYCS, EI24, CHEK2, BID, CCNE1, SFN, PERP, IGFBP3, GTSE1, SERPINB5, TP73, CCND3, CHEK1, SHISA5, PTEN, CASP8, RRM2, CDKN1A, CCNB1",0.405607449624573,0,FALSE +"H1650","Input","KEGG_PANCREATIC_CANCER",0.35285,1.03,0.413,4020,1,"E2F1, STAT1, MAP2K1, TGFA, AKT2, STAT3, RAC1, SMAD2, TGFBR2, ERBB2, EGF, RAD51, RALA, EGFR, MAPK3, RALBP1, PIK3R3, AKT3, BCL2L1, BAD, RAF1, RALB",0.384049948343599,0,FALSE +"H1650","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.19433,0.564,0.972,5637,1,"PPCS, UPB1, PANK4, DPYD, PPCDC",0.0123337350737254,0,FALSE +"H1650","Input","KEGG_PARKINSONS_DISEASE",0.20965,0.61,0.952,4938,1,"NDUFAB1, UQCRC2, PINK1, UBE2G1, CYCS, CYC1, UQCRFS1, UBE2L6, TH, UBA7, NDUFS6, NDUFB8, COX6B1, UQCR10, NDUFA8, UBE2G2, SDHA, NDUFB1, NDUFV2, COX6C, SDHB, NDUFB3, NDUFB9, COX8A, NDUFB6, PARK7, NDUFB7",0.0213630516155257,0,FALSE +"H1650","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.32728,0.951,0.531,6605,0.967,"CDH1, YWHAZ, ACTB, OCLN, TUBA4A, KRT18, CD14, ARPC3, TUBB8, ARPC5L, ITGB1, RHOA, TUBB6, EZR, ROCK1, CDC42, CLDN1, NCK2, YWHAQ, TUBA8, TUBB4B, TUBB3, TUBA1B",0.274905478918531,0.0145735259169983,FALSE +"H1650","Input","KEGG_PATHWAYS_IN_CANCER",0.28172,0.815,0.747,5527,0.986,"CSF1R, TCF7L1, E2F1, CBLC, STAT1, CDH1, PDGFB, WNT9A, MAP2K1, CYCS, TFG, IL6, RASSF5, LAMA5, PLCG2, PTK2, FGFR2, EGLN3, ITGA6, EPAS1, GLI3, TGFA, BID, CCNE1, FGF11, FGF2, TRAF4, WNT7B, AKT2, PDGFA, STAT3, JUP, MTOR, RAC1, DAPK2, SMAD2, WNT7A, EGLN2, LAMA3, MITF, PPARG, TGFBR2, WNT6, ERBB2, CUL2, FZD6, TCF7L2, EGF, PTEN, RAD51, NFKB2, DAPK1, FZD9, CTNNA1, RALA, RXRA, EGFR, STK4, CTBP2, LAMB2, PIAS1, MAPK3, RALBP1, CASP8, PIK3R3, RUNX1, AKT3, LAMB1, BCL2L1, FZD2, LAMC2, BAD, RAF1, SKP2, RBX1, RALB, LAMB3, SOS1, CDKN1A, ITGAV, PLD1, EP300, BMP2, CCNE2, CCNA1, ITGA3, ITGB1, FZD1, GRB2, RHOA, HDAC1, LAMC1, MET, FOS, ELOC, PML, JAK1, KITLG, WNT9B, RALGDS, CDC42, FGF1, APPL1, MMP2, PLCG1",0.126679398184601,0.0061230850587888,FALSE +"H1650","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.31844,0.917,0.603,4890,0.961,"UGT2B17, UGP2, RPEL1, RPE, DHDH, AKR1B1",0.219682687859849,0.0172766123314547,FALSE +"H1650","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.36285,1.06,0.366,3657,1,"PGM1, PGLS, RPEL1, FBP2, GPI, RBKS, RPE, ALDOA, DERA",0.436518914605589,0,FALSE +"H1650","Input","KEGG_PEROXISOME",0.31307,0.911,0.593,5734,0.938,"PXMP4, XDH, ACAA1, ECH1, SLC25A17, NUDT19, ACOX1, PEX10, PEX13, PRDX5, ACOT8, ACSL1, MPV17L, PEX3, MVK, DECR2, ACSL3, PEX14, SOD1, PRDX1, GSTK1, IDH2, ABCD1, IDH1, AGPS",0.226945306635737,0.0277971616209356,FALSE +"H1650","Input","KEGG_PHENYLALANINE_METABOLISM",0.32357,0.931,0.575,5986,0.972,"ALDH3B2, GOT2, TAT, PRDX6, ALDH1A3, ALDH3B1, MIF, GOT1",0.24033215531037,0.0123337350737254,FALSE +"H1650","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.34337,1,0.44,4869,1,"PLCD1, PLCE1, CALM3, CDS1, PLCG2, PIK3C2B, INPP4B, IMPA2, INPP5A, INPP1, ITPK1, DGKE, PIP4K2C, DGKA, INPP5E, PTEN, PIP5K1A, PIK3R3, SYNJ1, ITPR2, INPP4A, CALML6, INPPL1, PLCD3, IPPK, CALM1, PIK3C2G",0.356547323513813,0,FALSE +"H1650","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.45732,1.34,0.0923,3279,1,"EARS2, UGT2B17, BLVRB, HMOX2, FTH1, ALAS1, UROS, HMOX1, ALAS2, COX15",1.03479829897409,0,FALSE +"H1650","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.2677,0.774,0.827,3351,0.993,"SLC27A6, SCD5, ANGPTL4, SLC27A4, ACAA1, ACOX1, PPARG, ACSL1, FABP5, RXRA",0.0824944904474534,0.00305075150461883,FALSE +"H1650","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.37845,1.09,0.323,245,1,"CYP7B1",0.490797477668897,0,FALSE +"H1650","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.24562,-0.945,0.479,15016,0.8,"ZAP70, LCK, CD3D, IL2RG, CD19, RAG1, BTK, TNFRSF13C, IGLL1, CD4, DCLRE1C, JAK3, RFXAP",0.319664486585437,0.0969100130080564,FALSE +"H1650","Input","KEGG_PRION_DISEASES",0.36312,1.07,0.356,3687,1,"CCL5, MAP2K1, IL6, HSPA1A, PRKACG, STIP1, MAPK3, PRKACA",0.448550002027125,0,FALSE +"H1650","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.32122,0.935,0.567,5242,0.971,"PLK1, MAPK11, MAP2K1, AKT2, PKMYT1, RPS6KA1, ANAPC2, SPDYA, PRKACG, ADCY1, ANAPC10, MAPK13, ADCY7, CDC23, MAPK3, PIK3R3, PRKACA, AKT3, RAF1, ANAPC7, CCNB1, CDC25A, CDC25B, GNAI1, CCNA1, ADCY6, CCNA2, BUB1, MAD2L2",0.246416941107093,0.0127807700919951,FALSE +"H1650","Input","KEGG_PROPANOATE_METABOLISM",-0.26429,-1.01,0.352,16336,0.817,"SUCLA2, LDHC, EHHADH, PCCB, ACADM, ALDH1B1, ALDH2, ACSS3, ALDH6A1, PCCA",0.453457336521869,0.0877779434675845,FALSE +"H1650","Input","KEGG_PROSTATE_CANCER",0.289,0.843,0.751,4535,0.971,"TCF7L1, E2F1, PDGFB, MAP2K1, FGFR2, TGFA, CCNE1, AKT2, PDGFA, PDGFC, PDGFD, MTOR, ERBB2, TCF7L2, EGF, PTEN, EGFR, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1, CDKN1A, EP300, CCNE2",0.124360062995832,0.0127807700919951,FALSE +"H1650","Input","KEGG_PROTEASOME",0.29886,0.866,0.695,6227,0.971,"PSMA2, PSMB10, PSMC4, PSMA7, PSMB6, PSMD11, PSMB3, PSMD8, PSMD12, PSMF1, PSMD7, PSMB1, PSMB11, PSMB2, PSMC3, PSMA6, PSMA4, PSMB9, PSMB7",0.158015195409886,0.0127807700919951,FALSE +"H1650","Input","KEGG_PROTEIN_EXPORT",-0.33128,-1.18,0.2,17269,0.839,"SPCS2, SEC62, IMMP2L, OXA1L, SEC63",0.698970004336019,0.0762380391712997,FALSE +"H1650","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.24015,0.702,0.899,2164,0.995,"GLS, MDH1, SLC25A10",0.0462403082667712,0.00217691925427455,FALSE +"H1650","Input","KEGG_PURINE_METABOLISM",0.20608,0.602,0.965,6278,0.993,"POLR2K, XDH, GDA, POLR3H, PAPSS2, POLR2I, POLE4, POLR2C, POLD1, DGUOK, ADK, NME4, NUDT9, ENTPD6, POLR3K, ADCY1, PAPSS1, NPR1, NME3, POLE, ADCY7, ADA, AK2, PDE8A, PDE5A, POLA2, RRM2, POLR2A, POLD2, NME6, GUCY1B1, PDE6G, GUCY1A1, ADCY6, ENTPD2, POLR1A, GUCY1A2, AK4, AK1, POLR2F, NT5C3A, PDE9A, DCK, NT5C2, ENTPD5, ATIC, PNPT1, POLD3, PKM, PAICS",0.0154726866562074,0.00305075150461883,FALSE +"H1650","Input","KEGG_PYRIMIDINE_METABOLISM",0.35272,1.02,0.425,4082,1,"DHODH, POLR2K, CDA, POLR3H, POLR2I, POLE4, POLR2C, POLD1, DTYMK, CMPK2, TYMP, NME4, TK1, ENTPD6, POLR3K, UPP1, CTPS1, NME3, POLE, UPB1, UCKL1, DUT, POLA2, RRM2, POLR2A, TK2, POLD2, NME6",0.371611069949688,0,FALSE +"H1650","Input","KEGG_PYRUVATE_METABOLISM",0.32653,0.947,0.544,6578,0.968,"PC, MDH1, LDHAL6B, ACSS2, GRHPR, ACSS1, MDH2, AKR1B1, ALDH3A2, PDHA1, ACAT2, ALDH9A1, PKM, ME3, PDHB",0.26440110030182,0.0141246426916063,FALSE +"H1650","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.3528,1.03,0.434,5643,1,"PFN4, SSH2, ITGA4, PAK4, ARHGAP35, ITGB2, PDGFB, MYL9, CHRM4, MYH14, BCAR1, MAP2K1, ITGA1, VAV3, PTK2, FGFR2, ITGA6, ACTB, ARHGEF1, FGD3, PXN, FGF11, FGF2, PDGFA, PDGFC, ITGB8, PDGFD, TIAM1, SLC9A1, LIMK2, ACTN4, RAC1, BAIAP2, VAV1, RDX, PFN1, MYLK2, PIP4K2C, RRAS, PPP1CB, CD14, ARPC3, EGF, PIP5K1A, EGFR, CYFIP1, PAK6, VAV2, MAPK3, SSH3, PIK3R3, MYL5, ARPC5L, RAF1, BRK1, SOS1, TIAM2, ITGAV, MYL7, MRAS, GNA12, ITGA3, ITGB1, MYH9, MYL12B, ITGB4, SCIN, NCKAP1, RHOA, CFL2, EZR, PAK2, ROCK1, CDC42, ITGAE, FGF1, IQGAP1, CFL1, LIMK1, ACTN1",0.362510270487489,0,FALSE +"H1650","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.45218,1.3,0.101,3126,1,"IFNA5, GABARAPL2, ATG12, PRKAA1, ATG4B, ULK2, ATG7, ATG4D",0.995678626217357,0,FALSE +"H1650","Input","KEGG_RENAL_CELL_CARCINOMA",0.40227,1.17,0.221,7564,1,"GAB1, PAK4, PDGFB, MAP2K1, EGLN3, RAP1A, EPAS1, TGFA, AKT2, RAPGEF1, RAC1, EGLN2, CUL2, PAK6, MAPK3, PIK3R3, AKT3, RAF1, RBX1, SOS1, EP300, GRB2, MET, PAK2, ELOC, CDC42, SLC2A1, HRAS, PIK3CB, TGFB3, VEGFB, BRAF, CRKL, VEGFC, SOS2, CRK, TGFB2, FLCN, CREBBP, ETS1, TGFB1",0.655607726314889,0,FALSE +"H1650","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.4735,1.38,0.0652,1966,1,"ACE2, ANPEP, MME, CTSA",1.18575240426808,0,FALSE +"H1650","Input","KEGG_RETINOL_METABOLISM",0.17876,0.519,0.989,1040,0.992,"DHRS9, UGT2B17, CYP26B1",0.0048037084028206,0.00348832784582135,FALSE +"H1650","Input","KEGG_RIBOFLAVIN_METABOLISM",0.23988,0.694,0.894,4592,0.982,"MTMR2, ACP2, MTMR1, ACP1, PHPT1",0.0486624812040823,0.00788851221305034,FALSE +"H1650","Input","KEGG_RIBOSOME",-0.68738,-2.62,0,16978,0.00834,"RPL34, RPL4, RPL35A, RPL19, RPL26, RPL39, RPS17, RPL17, RPL37A, RPS7, RPL18A, RPS4Y1, RPS3, RPS29, RPL9, RPL38, RPL7, RPL5, RPS3A, RPLP0, RPL22L1, RPL31, RPL23A, RPS27A, RPS23, RPL27, RPS8, RPS25, RPS4X, RPS27, RPL36A, RPS15, RPS18, RPL3, RPS28, RPS10, RPL10A, RPL21, RPL10, RPL36, RPLP2, RPS12, RPL27A, RPS13, RPL30",Inf,2.07883394936226,TRUE +"H1650","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.38733,1.12,0.272,4825,1,"IFNA5, DDX58, IRF3, IFIH1, TRADD, ISG15, MAPK11, ATG12, IFNB1, IL12A, CYLD, TANK, IL12B, NFKBIB, MAPK13, CASP8, AZI2, DHX58, TKFC, TRIM25, TBK1, TBKBP1",0.565431095965801,0,FALSE +"H1650","Input","KEGG_RNA_DEGRADATION",0.37899,1.09,0.317,4271,1,"PARN, EXOSC6, LSM4, EDC4, DCPS, TENT4A, CNOT3, PATL1, CNOT1, EXOSC1, C1D, SKIV2L, EXOSC4, CNOT8, CNOT4, LSM5, LSM3, PAPOLB, EXOSC3, EXOSC5, EXOSC10",0.498940737782249,0,FALSE +"H1650","Input","KEGG_RNA_POLYMERASE",0.30447,0.886,0.636,1179,0.958,"POLR2K, POLR3H, POLR2I, POLR2C",0.196542884351586,0.0186344909214556,FALSE +"H1650","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.32823,0.954,0.526,5641,0.981,"PAPSS2, PAPSS1, AHCYL2, AHCY, CBS, LCMT1, GGT1, GGT7, MAT2B, MAT2A",0.279014255846261,0.0083309926200515,FALSE +"H1650","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.24963,0.727,0.871,4699,0.99,"E2F1, CYCS, LAMA5, PTK2, ITGA6, CCNE1, TRAF4, AKT2, LAMA3, PTEN, RXRA, LAMB2, PIAS1, PIK3R3, AKT3, LAMB1, BCL2L1, LAMC2, SKP2, LAMB3, ITGAV, CCNE2, ITGA3, ITGB1",0.0599818449923368,0.00436480540245009,FALSE +"H1650","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.18256,0.526,0.991,3492,1,"STX11, YKT6, STX16, VAMP8, VTI1A",0.00392634551472468,0,FALSE +"H1650","Input","KEGG_SPHINGOLIPID_METABOLISM",0.28335,0.814,0.782,4756,0.98,"SPTLC1, SMPD4, SPHK2, ARSA, DEGS1, GALC, NEU2, SMPD3, B4GALT6, SGMS2",0.106793246940152,0.00877392430750515,FALSE +"H1650","Input","KEGG_SPLICEOSOME",0.29423,0.855,0.706,6805,0.962,"SF3B3, DHX38, HSPA2, CTNNBL1, PCBP1, LSM4, PRPF31, AQR, SRSF6, PUF60, TRA2A, SNRNP70, USP39, PHF5A, HSPA1A, U2AF2, SRSF9, SNRPA, HSPA1B, SNRPD3, PRPF40B, PRPF38A, SNRNP27, CHERP, U2SURP, LSM5, LSM3, SMNDC1, SNRPD2, TXNL4A, PPIE, BCAS2, SNRPG, PRPF4, ALYREF, SF3B4, BUD31, PRPF6, ZMAT2, DHX15, LSM6, SRSF4, PRPF38B, PLRG1, SNRPA1, RBM22, DDX46, DDX42, RBM25, HSPA6, HNRNPK, CWC15, PRPF8, SRSF8, SF3B5, PQBP1, WBP11",0.151195298948196,0.0168249279621871,FALSE +"H1650","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.27188,0.798,0.796,6169,0.985,"UGT2B17, GYS1, UGP2, PGM1, AMY1A, GPI, HK2, HK1, AMY1B, UXS1, PYGL, PGM2, AGL",0.0990869322623309,0.00656376950238827,FALSE +"H1650","Input","KEGG_STEROID_BIOSYNTHESIS",0.24322,0.711,0.897,7038,0.993,"DHCR24, SQLE, MSMO1, SOAT1, SC5D, EBP, LIPA",0.0472075569559079,0.00305075150461883,FALSE +"H1650","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.39955,1.16,0.246,1208,1,"SULT2B1, SULT1E1, CYP7B1, SRD5A1, UGT2B17, CYP1B1",0.609064892896621,0,FALSE +"H1650","Input","KEGG_SULFUR_METABOLISM",0.72982,2.13,0,4125,0.058,"SULT2B1, SULT1E1, PAPSS2, SULT1A4, CHST12, PAPSS1, SULT1A3, CHST11, SULT1A2, SUOX",Inf,1.23657200643706,TRUE +"H1650","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.16749,-0.559,1,14929,0.989,"FCGR2C, C7, GRIN2B, CD86, CTSG, C1S, C4B, ACTN2, C4A, FCGR2A, TNF, SNRPD1, C1R, C2",0,0.0048037084028206,FALSE +"H1650","Input","KEGG_TASTE_TRANSDUCTION",0.44181,1.28,0.127,4814,1,"KCNB1, TAS2R1, GNAS, GNG13, TAS2R43, TAS2R20, PRKACG, SCNN1G, TAS2R46, PRKACA, GRM4, TAS2R5, ASIC2, ADCY6",0.896196279044043,0,FALSE +"H1650","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.42673,1.25,0.158,4965,1,"CSAD, GAD1, GGT1, GGT7",0.801342913045577,0,FALSE +"H1650","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.29894,-1.12,0.239,17791,0.698,"IDI1, FDPS, PDSS2",0.621602099051862,0.156144577376839,FALSE +"H1650","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.25714,0.742,0.865,5940,1,"BMP5, PPP2R1A, RBL2, E2F4, BMP7, SMAD2, NOG, ZFYVE16, TGFBR2, SMAD6, GDF6, ACVR2A, MAPK3, RBL1, ID1, RBX1, EP300, BMP2, AMH, SMAD1, RHOA, ID4, BMPR1A, ROCK1, PPP2CA, CUL1, ID3, THBS1, SMURF1",0.0629838925351858,0,FALSE +"H1650","Input","KEGG_THYROID_CANCER",0.38796,1.13,0.27,3590,1,"TCF7L1, CDH1, MAP2K1, TFG, PPARG, TCF7L2, RXRA, MAPK3",0.568636235841013,0,FALSE +"H1650","Input","KEGG_TIGHT_JUNCTION",0.43013,1.24,0.166,6038,0.99,"MYH15, SPTAN1, EPB41L1, MYL9, MYH14, PPP2R1A, SYMPK, CGN, PRKCD, ACTB, CSNK2A2, MYH3, TJP3, TJP1, AKT2, F11R, OCLN, ACTN4, AMOTL1, CLDN7, CLDN23, LLGL2, CLDN4, EXOC3, PARD3, RRAS, PARD6B, MAP3K20, AFDN, PTEN, CTNNA1, YBX3, TJP2, AKT3, PRKCI, CASK, MYL5, PRKCZ, PRKCE, PPP2R2D, MYL7, GNAI1, MRAS, CLDN9, MYH9, MYL12B, RHOA, VAPA, PATJ, PPP2R2C, MPDZ, CLDN8, PPP2CA, CDC42, CLDN1, ACTN1, PRKCH, MYH7B, MAGI1, HRAS",0.779891911959945,0.00436480540245009,FALSE +"H1650","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.40139,1.17,0.222,3889,1,"CCL5, TLR1, IFNA5, TLR6, STAT1, IRF3, MAPK11, MAP2K1, IL6, IFNB1, CD40, IL12A, AKT2, RAC1, MAP3K8, MYD88, TAB2, IL12B, CD14, MAPK13, TLR3, TIRAP, MAPK3, CASP8, PIK3R3, AKT3, TICAM2",0.653647025549361,0,FALSE +"H1650","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.20627,-0.769,0.805,16293,0.908,"IDO1, AOC1, AFMID, EHHADH, MAOB, ALDH1B1, KYNU, ALDH2, TPH1, MAOA, WARS2",0.0942041196321315,0.0419141514789149,FALSE +"H1650","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.19465,-0.728,0.868,15050,0.947,"CACNA1A, SLC2A4, PIK3CG, MAPK8, CACNA1B, PIK3R1, PIK3CD, CACNA1G, TNF, CACNA1C, GCK, IRS2, KCNJ11, IRS1, INSR, IKBKB",0.0614802748235081,0.0236500209967266,FALSE +"H1650","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.21764,0.636,0.945,2786,1,"IL12A, IL12B, GAD1",0.0245681914907371,0,FALSE +"H1650","Input","KEGG_TYROSINE_METABOLISM",-0.16285,-0.6,0.988,18363,1,"FAH, METTL2B, MAOA, GSTZ1",0.00524305541237188,0,FALSE +"H1650","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.31339,0.915,0.573,5345,0.947,"CHP1, PAK4, CBLC, PPP3R1, MAPK11, MAP2K1, PPP3CA, VAV3, NFAT5, MAP3K14, AKT2, MALT1, VAV1, MAP3K8, NFATC1, NFKBIB, MAPK13, PAK6, NFATC3, VAV2, MAPK3, PIK3R3, AKT3, RAF1, SOS1, PTPN6, GRB2, RHOA, FOS, PAK2, CDC42",0.24184537803261,0.0236500209967266,FALSE +"H1650","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.41684,1.22,0.163,5940,0.972,"FBXO2, UBE2D4, SIAH1, FBXW7, UBR5, CBLC, WWP2, UBE2G1, HUWE1, ITCH, NEDD4L, UBE2E2, UBA2, UBE2L6, HERC3, SOCS1, ANAPC2, UBA7, SAE1, UBE2M, CUL2, UBE2E1, UBE2S, ANAPC10, CDC23, MID1, FANCL, WWP1, UBE4B, NHLRC1, PIAS1, HERC1, UBE2C, UBE2G2, UBE2D3, SKP2, RBX1, UBE3B, ANAPC7, UBE3A, NEDD4, KEAP1, FBXW8, UBE2K, CDC20, UBE2R2, UBE2Z, ELOC, PML, TRIP12, BIRC6, FBXO4, UBE2H, BRCA1, CUL1, BIRC2, UBE2B, SMURF1",0.787812395596042,0.0123337350737254,FALSE +"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.43174,1.24,0.163,6890,0.99,"PDHA1, PDHB, BCAT2, IARS2",0.787812395596042,0.00436480540245009,FALSE +"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.28153,0.826,0.756,7002,0.989,"ABAT, ACAA1, BCKDHA, HIBADH, ACAD8, MCEE, AOX1, ECHS1, HADHA, OXCT1, HMGCS1, MCCC2, ALDH3A2, ACAT2, HSD17B10, HADHB, ALDH9A1, ACAA2, BCAT2, MCCC1, OXCT2",0.121478204498793,0.0048037084028206,FALSE +"H1650","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.31606,0.925,0.591,4851,0.958,"ADORA2A, CALM3, MYL9, GNAS, CACNA1D, MAP2K1, PRKCD, PLA2G12A, ARHGEF1, KCNMB4, ADRA1B, PLA2G4B, GNAQ, PRKACG, ADCY1, MYLK2, NPR1, PPP1CB, ADCY7, KCNMA1, MAPK3, ADORA2B, PRKACA, KCNMB3, ITPR2, RAF1, GUCY1B1, PRKCE, CALML6, GUCY1A1, GNA12, CALM1, ADCY6, RHOA",0.228412519118745,0.0186344909214556,FALSE +"H1650","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.33906,0.974,0.502,6295,0.989,"DYNC1LI2, GNAS, DCTN1, DCTN5, DYNLL2, PRKACG, ARHGDIB, RAB11A, PRKACA, DYNC1H1, AQP3, RAB5C, ADCY6, CREB3, RAB5A, DYNLL1, STX4, PRKACB, CREB3L1",0.299296282854981,0.0048037084028206,FALSE +"H1650","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.41642,1.23,0.169,3976,0.999,"CHP1, HSPB1, PPP3R1, MAPK11, MAP2K1, PPP3CA, PLCG2, PTK2, PLA2G12A, NFAT5, PXN, AKT2, PLA2G4B, SPHK2, MAPKAPK3, RAC1, NFATC1, MAPK13, NFATC3, MAPK3, PIK3R3, AKT3, BAD, RAF1",0.772113295386326,0.000434511774017692,FALSE +"H1650","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.42622,1.24,0.169,5632,0.99,"ATP6V0D1, ERO1A, GNAS, ATP6V1C1, PLCG2, ACTB, TJP1, KDELR1, PRKACG, ATP6V0A1, ATP6V0C, PRKACA, TJP2, ATP6AP1, KDELR2, SEC61G, ARF1, ATP6V1B1, ATP6V0A4, PLCG1, ATP6V1E1, SEC61A2",0.772113295386326,0.00436480540245009,FALSE +"H1650","Input","KEGG_VIRAL_MYOCARDITIS",0.50373,1.46,0.0401,2152,1,"MYH15, DAG1, ITGB2, MYH14, CYCS, ACTB, CD40, MYH3, BID, EIF4G1, CXADR, RAC1",1.39685562737982,0,FALSE +"H1650","Input","KEGG_WNT_SIGNALING_PATHWAY",0.2983,0.86,0.693,4006,0.967,"CHP1, TCF7L1, CAMK2G, SIAH1, WNT9A, PPP2R1A, PPP3R1, PPP3CA, NFAT5, CSNK2A2, PPP2R5E, CTNNBIP1, WNT7B, RAC1, SMAD2, WNT7A, NFATC1, WNT6, CAMK2D, VANGL2, PRKACG, CCND3, FZD6, TCF7L2, FZD9, CTBP2, NFATC3, DAAM1, PRKACA, LRP5, FZD2, RBX1",0.159266765388193,0.0145735259169983,FALSE +"HCC95","Input","KEGG_ABC_TRANSPORTERS",0.30702,1.01,0.428,1853,0.783,"ABCG1, ABCC1, ABCA4, ABCB6, ABCA13, TAP2, ABCC5",0.368556230986828,0.106238237942057,FALSE +"HCC95","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.30346,0.985,0.449,4099,0.807,"EIF4EBP1, IKBKB, GRB2, BAD, PIK3CA, JUP, PIK3R2, CEBPA, MYC, LEF1, BRAF, PIK3CB, CCNA1, KRAS, PML, HRAS, MAPK1, PIM1, RUNX1, AKT2",0.347753658996677,0.0931264652779296,FALSE +"HCC95","Input","KEGG_ADHERENS_JUNCTION",0.27962,0.927,0.52,5098,0.866,"NECTIN1, RAC3, YES1, NLK, PTPN6, EGFR, SNAI2, LEF1, CDH1, CSNK2A2, MET, MAP3K7, IGF1R, WASF3, PTPRB, CSNK2A1, TJP1, MAPK1, SRC, PTPN1, SMAD2, TGFBR1, BAIAP2, RAC1, ERBB2",0.283996656365201,0.0624821079826534,FALSE +"HCC95","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.44892,1.5,0.0581,4121,0.501,"ADIPOR1, ACSL6, ADIPOR2, POMC, IKBKB, CAMKK1, RXRA, IRS1, CPT1A, MAPK9, MAPK10, ACSL3, SLC2A4, NFKBIB, PRKAA1, PRKCQ, SLC2A1, ACACB, PRKAG2, MAPK8, TRADD, AKT2, CAMKK2",1.23582386760967,0.300162274132754,FALSE +"HCC95","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.49111,1.62,0.0311,3522,0.454,"GLS2, GLUL, GOT2, ASNS, ALDH4A1, CAD, ASS1, GOT1, ALDH5A1, GPT2, GAD1",1.50723961097316,0.342944147142896,FALSE +"HCC95","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.29786,0.987,0.438,3156,0.812,"ATP1B3, SFN, SCNN1A, PIK3CA, PIK3R2, IRS1, ATP1A1, PIK3CB, KRAS",0.3585258894959,0.0904439707588247,FALSE +"HCC95","Input","KEGG_ALLOGRAFT_REJECTION",0.21337,0.694,0.896,15037,1,"CD40, CD86, IL12A, FAS, IFNG, CD40LG, IL2, CD28, FASLG, IL12B, GZMB, CD80, IL4, PRF1, IL10, TNF, IL5",0.0476919903378748,0,FALSE +"HCC95","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.33598,1.09,0.311,2278,0.708,"FADS2, PLA2G4B, PLA2G4A, PLA2G12A",0.507239610973163,0.149966742310231,FALSE +"HCC95","Input","KEGG_ALZHEIMERS_DISEASE",0.2159,0.709,0.876,4348,1,"CALML3, NDUFB5, NDUFB7, PPP3R2, NOS1, SNCA, GAPDH, NDUFS6, BAD, ATP5MC1, ATP5PD, PLCB1, NDUFA9, COX5A, ITPR3, NDUFV2, ATP2A3, NDUFB10, CAPN1, NAE1, NDUFA4L2, IL1B, BID, UQCRFS1, ADAM17, SDHD, NDUFA2, ATP2A2, SDHA, MAPK1, NDUFS4, NDUFA8, CDK5, PLCB3, CACNA1D, COX7C",0.0574958938319193,0,FALSE +"HCC95","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.39923,-1.49,0.0692,16276,0.356,"PARS2, LARS2, TARS2, FARSA, PSTK, CARS2, YARS2, FARS2",1.15989390554324,0.448550002027125,FALSE +"HCC95","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.33085,-1.27,0.114,16584,0.473,"FPGT, HK2, RENBP, GNE, GMDS, GALE, GMPPA, GALT, PGM1, PMM1, UAP1, NAGK",0.943095148663527,0.325138859262188,FALSE +"HCC95","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.37768,1.23,0.188,2891,0.575,"CAT, NEFL, PPP3R2, CASP1, NOS1, BCL2, NEFM, BAD, MAPK13, DAXX, MAPK12, MAP2K6, BID",0.72584215073632,0.24033215531037,FALSE +"HCC95","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.26382,0.858,0.656,4226,0.895,"CANX, HSP90AB1, HSPA1B, RFXANK, PSME3, TAP2, RFXAP, IFI30, CD8A, KIR2DL3, TAP1, TAPBP, HSPA4, PDIA3",0.18309616062434,0.048176964684088,FALSE +"HCC95","Input","KEGG_APOPTOSIS",0.23221,0.761,0.8,3028,0.985,"IL1A, IL1RAP, PPP3R2, IKBKB, BCL2, NGF, BAD, PIK3CA, PIK3R2, PRKACA, ENDOD1, ENDOG, CAPN1, TNFSF10, IL1B, BID, PIK3CB",0.0969100130080564,0.00656376950238827,FALSE +"HCC95","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.46762,1.56,0.0455,2278,0.467,"CYP4F3, AKR1C3, GPX2, ALOX12B, PTGES2, GPX3, CBR1, EPHX2, CBR3, PLA2G4B, LTC4S, TBXAS1, PLA2G4A, PLA2G12A",1.34198860334289,0.330683119433888,FALSE +"HCC95","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.41436,1.37,0.109,3357,0.508,"GLS2, PYCR2, GLUL, CKMT1B, CKMT1A, NOS1, GOT2, PYCR1, ALDH3A2, ALDH4A1, ASS1, NOS2, GOT1, GAMT, GATM, PYCR3, OAT, CKB, ALDH2",0.962573502059376,0.294136287716081,FALSE +"HCC95","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.18401,0.593,0.978,3704,0.998,"CACNA2D3, CACNG4, JUP, ITGB4, PKP2, ITGA2, LEF1, CACNB1, DSG2, ITGA6, ITGA2B, CDH2, SLC8A1, ATP2A2, GJA1",0.00966114521239857,0.000869458712628891,FALSE +"HCC95","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.43946,-1.56,0.063,18925,0.499,"ALDH9A1, ALDH7A1",1.20065945054642,0.30189945437661,FALSE +"HCC95","Input","KEGG_ASTHMA",0.23332,0.763,0.783,622,0.99,"EPX",0.106238237942057,0.00436480540245009,FALSE +"HCC95","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.23195,-0.838,0.656,8962,0.994,"IFNA4, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, IL2, CD28, FASLG, TPO, GZMB, TSHB, CD80, IFNA13, IL4, CTLA4, PRF1, IL10, IFNA21, CGA, IFNA1, IFNA5, TSHR, IL5",0.18309616062434,0.00261361560268669,FALSE +"HCC95","Input","KEGG_AXON_GUIDANCE",0.22644,0.744,0.834,3156,0.973,"PAK2, SEMA4D, RAC3, PPP3R2, EFNB1, SEMA4A, SEMA3F, NTN1, EFNB3, EPHA1, DPYSL5, EPHB4, SEMA4F, PAK6, NCK1, UNC5B, GNAI1, NFATC1, PAK1, ABLIM1, EPHA8, EPHB3, RHOD, EPHB6, MET, SEMA4B, KRAS",0.0788339493622613,0.0118871597316481,FALSE +"HCC95","Input","KEGG_BASAL_CELL_CARCINOMA",0.55164,1.8,0.0119,2279,0.357,"WNT3A, FZD1, WNT5A, WNT8B, GLI2, FZD10, DVL3, WNT10A, SMO, WNT7B, WNT11, WNT10B, FZD9, WNT9A, AXIN1, PTCH1, WNT7A, WNT16, WNT4, LEF1",1.92445303860747,0.447331783887807,FALSE +"HCC95","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.39984,1.31,0.122,5303,0.537,"STON1, TAF6, TAF11, GTF2H4, GTF2F2, TAF4B, GTF2IRD1, GTF2H3, TAF7, TAF5L, TAF6L, GTF2A2, TAF4, TAF9B, GTF2I, TAF1, GTF2H2, GTF2A1L, TAF5",0.913640169325252,0.270025714300444,FALSE +"HCC95","Input","KEGG_BASE_EXCISION_REPAIR",0.37934,1.25,0.18,2468,0.582,"POLB, UNG, PCNA, FEN1, POLE2, POLD2, POLE3, PARP1, HMGB1, NTHL1",0.744727494896694,0.235077015350112,FALSE +"HCC95","Input","KEGG_BETA_ALANINE_METABOLISM",-0.34586,-1.24,0.169,17649,0.465,"DPYD, ACADM, ALDH9A1, SMS, ALDH7A1",0.772113295386326,0.332547047110046,FALSE +"HCC95","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.36381,1.2,0.182,2850,0.606,"TECR, SCD, FADS2, FADS1, HADHA, ELOVL5, SCD5",0.739928612014925,0.217527375833714,FALSE +"HCC95","Input","KEGG_BLADDER_CANCER",-0.25625,-0.889,0.549,16469,0.922,"MDM2, MMP1, RAF1, DAPK3, TYMP, DAPK1, CDKN2A, RASSF1, ARAF",0.260427655549908,0.0352690789463706,FALSE +"HCC95","Input","KEGG_BUTANOATE_METABOLISM",0.33926,1.12,0.27,3522,0.716,"AKR1B10, HMGCS1, EHHADH, ALDH3A2, BDH1, L2HGDH, HADHA, ACAT2, ALDH5A1, OXCT1, ALDH2, GAD1",0.568636235841013,0.145086977692144,FALSE +"HCC95","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.25356,0.823,0.696,3328,0.93,"SYK, RAC3, PPP3R2, IKBKB, PTPN6, GRB2, PIK3CA, PIK3R2, LYN, NFATC1, IFITM1, MALT1, NFKBIB, PIK3CB, KRAS, FOS, HRAS",0.157390760389438,0.0315170514460649,FALSE +"HCC95","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.23852,0.789,0.763,2808,0.966,"CALML3, VDAC3, ADCY3, PPP3R2, NOS1, CHRNA7, VDAC2, ADRA1A, EGFR, PLCB1, PHKB, ADORA2B, ADCY1, GNAL, CAMK4, GNA15, PRKACA, PTAFR, ADRB2, ATP2B4, ITPR3, ATP2A3, CHRM3, PLCD1, TACR1, NOS2, HTR2C",0.11747546204512,0.0150228735845067,FALSE +"HCC95","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.19759,0.642,0.939,5223,0.995,"TNNI3, CACNA2D3, ATP1B3, CACNG4, COX5A, ATP1A1, CACNB1, UQCRFS1, SLC8A1, ATP2A2, CACNA1D, COX7C, MYL2, TPM4, COX5B, CYC1, UQCRHL, UQCRC1, COX8A",0.0273344077338891,0.00217691925427455,FALSE +"HCC95","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.18793,0.621,0.954,3590,0.989,"CLDN8, CLDN11, NECTIN1, CNTN1, SDC1, CDH3, CNTNAP2, JAM3, CLDN4, CLDN7, CDH1, ITGA6, CLDN1, F11R, CD8A, ICOSLG, CDH2, NEO1, CD40",0.0204516252959049,0.0048037084028206,FALSE +"HCC95","Input","KEGG_CELL_CYCLE",0.33735,1.09,0.323,5745,0.708,"YWHAG, MCM7, ANAPC1, CCNB2, SFN, MCM3, CDC6, SKP2, E2F4, TFDP1, ORC3, MCM4, ANAPC11, PCNA, GADD45G, ORC5, MYC, RB1, CDC23, CCND2, CCND3, CDC45, CUL1, RBL1, BUB1, CDC26, TFDP2, CCNA1, PKMYT1, BUB1B, DBF4, CDC14B, CDC25C, STAG1, CCNA2, TGFB2, CHEK1, PTTG1, MAD2L2, ANAPC7, HDAC1, CDC27, SMAD2, CDKN1B, ATR, PTTG2, CCND1, PRKDC, SKP1, CCNB1, TTK, CREBBP, E2F2, PLK1, BUB3, MAD2L1, ANAPC4, MCM6",0.490797477668897,0.149966742310231,FALSE +"HCC95","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.23257,0.763,0.797,3156,0.99,"GRK7, CXCR2, ADCY3, GRK6, ELMO1, IKBKB, GRB2, GNB2, GNG4, CCL19, CX3CL1, XCL2, PIK3CA, PIK3R2, PLCB1, ADCY1, CCL26, LYN, PRKACA, GNAI1, PAK1, GNB4, NFKBIB, CXCL14, BRAF, GNB5, CXCL16, ARRB2, PIK3CB, KRAS",0.0985416786038876,0.00436480540245009,FALSE +"HCC95","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.20635,0.678,0.916,4942,1,"IKBKB, GRB2, BAD, PIK3CA, PIK3R2, MYC, RB1, BCR, BRAF, CBLC, PIK3CB, KRAS, HRAS, CRKL, TGFB2, MAPK1, RUNX1, AKT2, HDAC1, MECOM, CDKN1B, TGFBR1, SHC1, CCND1",0.0381045263321496,0,FALSE +"HCC95","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.57348,-2.05,0.00722,15139,0.157,"BHLHE41, CRY1, PER1, NR1D1, NPAS2, CLOCK, CRY2",2.14146280243036,0.804100347590766,TRUE +"HCC95","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.35315,-1.29,0.151,17455,0.509,"ACO2, SDHC, PDHB, ACO1, SUCLG1, IDH3G, SUCLG2, PDHA1",0.821023052706831,0.293282217663241,FALSE +"HCC95","Input","KEGG_COLORECTAL_CANCER",0.28377,0.917,0.529,5155,0.862,"RAC3, BCL2, BAD, PIK3CA, PIK3R2, MSH6, AXIN1, MAPK9, MYC, MAPK10, LEF1, BRAF, PIK3CB, KRAS, FOS, TGFB2, BIRC5, MAPK1, MAPK8, AKT2, SMAD2, TGFBR1, CCND1, RAC1, MSH2",0.276544327964814,0.0644927341752872,FALSE +"HCC95","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.1956,-0.717,0.85,11767,1,"C9, C5AR1, C2, SERPINF2, FGB, F2, MASP1, C4BPA, F13A1, CFI, SERPINC1, F7, A2M, FGG, C7, SERPIND1, F10, F5, C3, PLG, CD55, MASP2, SERPINA5, C3AR1, C4BPB, SERPINA1, KLKB1, CD59, PLAUR, SERPING1, F2R, THBD, C4A, C8G, PROS1, C4B, CFB, TFPI",0.0705810742857073,0,FALSE +"HCC95","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.43542,1.44,0.0814,1547,0.498,"APIP, LDHC, GOT2, MAT2B, AHCY, ENOPH1",1.0893755951108,0.302770657240282,FALSE +"HCC95","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.12362,0.407,1,3613,1,"CXCR2, BMP7, FLT4, IL1A, IL1RAP, NGFR, PDGFA, EDAR, CCL19, CX3CL1, EGFR, XCL2, CCL26, IFNLR1, LTB, IL17RA, IL22RA1, TNFSF10, CXCL14, LTBR, IL1B, CXCL16, MET, TNFRSF21, PDGFB, TNFSF18, IL20RB, TNFSF15, IL10RB, CD40, TGFB2",0,0,FALSE +"HCC95","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.18491,-0.67,0.913,18304,0.995,"TBK1, DDX58, POLR3C, RIPK1",0.039529222465701,0.00217691925427455,FALSE +"HCC95","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.18254,-0.647,0.953,14293,0.972,"TNF, IGF1, ADCY5, CACNG7, SGCD, LAMA2, LMNA, SGCA, TNNC1, CACNB2, DES, RYR2, ITGA9, CACNA2D1, ADCY4, ITGA10, ITGB7, ITGB5, CACNA1C, DMD, CACNA2D4, CACNG6, PRKACB, CACNG8, ITGA7, ITGA1, ITGB3, ITGB1, ADCY6, ACTB, TGFB3, TPM2",0.0209070993616736,0.0123337350737254,FALSE +"HCC95","Input","KEGG_DNA_REPLICATION",0.61576,2.01,0.00409,4130,0.709,"RFC4, MCM7, MCM3, RFC2, MCM4, PCNA, RNASEH2B, FEN1, POLE2, POLD2, POLE3, RFC3, RPA3, PRIM1, SSBP1, RPA1, POLA2, RFC5, RNASEH2C, DNA2, PRIM2",2.38827669199266,0.149353764816933,FALSE +"HCC95","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.24456,0.8,0.757,3940,0.952,"GRB2, ETV7, EGFR, KRAS, SPIRE2, MAPK1, NOTCH1",0.120904120499927,0.0213630516155257,FALSE +"HCC95","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.32068,1.04,0.366,2955,0.769,"ADH7, ALDH3A1, UGT2B17, GSTM3, GSTP1, ADH5, GSTA4, GSTA1",0.436518914605589,0.114073660198569,FALSE +"HCC95","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.34161,1.14,0.269,1986,0.691,"GMPS, TPMT, IMPDH1, TK1, UGT2B17, HPRT1, CES1",0.570247719997592,0.160521952625802,FALSE +"HCC95","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.25009,0.813,0.73,3315,0.942,"LAMA1, VWF, CD44, COL4A6, SDC1, ITGB4, LAMC2, ITGA2, SPP1, LAMB3, SV2A, ITGA6, ITGA2B, THBS4, GP1BA, LAMA3",0.136677139879544,0.0259490972071227,FALSE +"HCC95","Input","KEGG_ENDOCYTOSIS",0.25311,0.833,0.7,3027,0.917,"GRK7, TRAF6, CXCR2, FGFR2, GRK6, ACAP2, PRKCI, RAB4A, EPN3, AP2M1, FGFR3, TFRC, MVB12A, GIT1, HSPA1B, SNF8, CHMP6, VPS4B, EGFR, AP2B1, SH3GL3, PIP4K2B, ADRB2, RAB5C, CLTCL1, PLD1, RAB31, RUFY1, RAB11FIP1, ITCH, CHMP1B, CBLC, ARAP3, MET, ARRB2, VPS25",0.154901959985743,0.0376306643299789,FALSE +"HCC95","Input","KEGG_ENDOMETRIAL_CANCER",-0.25355,-0.912,0.571,16363,0.925,"PIK3R3, PIK3R1, SOS1, RAF1, AXIN2, TCF7, TCF7L2, ILK, SOS2, GSK3B, ELK1, ARAF",0.243363891754152,0.0338582672609674,FALSE +"HCC95","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.3968,1.3,0.148,5491,0.543,"CXCR2, ATP6V1C2, PTPRZ1, ATP6V1E2, GIT1, IKBKB, EGFR, JAM3, MAPK13, LYN, MAPK9, PAK1, MAPK10, MAPK12, MET, F11R, ADAM17, HBEGF, ATP6V0A2, TJP1, MAPK8, ATP6V1G2, SRC, MAPK14, MAPK11, ATP6V0C, ATP6V0E2, RAC1, PLCG2, ATP6AP1, CSK, MAP3K14, IKBKG, ADAM10",0.829738284605043,0.265200170411153,FALSE +"HCC95","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.29124,0.948,0.49,4125,0.863,"NRG1, PAK2, NRG4, EIF4EBP1, GRB2, EGFR, BAD, PIK3CA, PIK3R2, PAK6, NCK1, MAPK9, MYC, PAK1, MAPK10, BRAF, CBLC, PIK3CB, KRAS, HBEGF, HRAS, CRKL, NCK2, MAPK1, MAPK8, PAK4, SRC, AKT2, CAMK2G",0.309803919971486,0.0639892042847904,FALSE +"HCC95","Input","KEGG_ETHER_LIPID_METABOLISM",0.30781,1,0.43,3292,0.788,"PLA2G4B, PLD1, PLA2G4A, PLA2G12A, PLPP1, PLPP2, PAFAH1B2, LPCAT2",0.366531544420413,0.103473782510445,FALSE +"HCC95","Input","KEGG_FATTY_ACID_METABOLISM",0.35809,1.18,0.23,3440,0.641,"ADH7, ACSL6, EHHADH, ALDH3A2, ECI1, CPT1A, ACSL3, HADHA, ADH5, ACAT2, ALDH2, HADHB",0.638272163982407,0.193141970481183,FALSE +"HCC95","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.26261,0.842,0.675,4493,0.914,"SYK, RAC3, GRB2, PIK3CA, PIK3R2, PLA2G4B, MAPK13, LYN, MAPK9, PLA2G4A, MAPK10, PLA2G12A, MAPK12, MAP2K6, PIK3CB, KRAS, HRAS, MAPK1, MAPK8, AKT2, MAPK14, MAPK11, VAV2",0.170696227168975,0.0390538042661686,FALSE +"HCC95","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.24326,-0.873,0.575,15255,0.932,"PLCG1, PLPP3, PLA2G4F, AMPH, INPP5D, PIP5K1B, FCGR1A, FCGR2A, PIK3R3, PIK3R1, ARPC3, ARPC4, RAF1, DOCK2, PIP5K1C, PLA2G6, ARF6, CDC42, LAT, PRKCA, ASAP2, CFL2, DNM2, GAB2, PIP5K1A, VASP, DNM1L, MARCKSL1",0.24033215531037,0.0305840876460186,FALSE +"HCC95","Input","KEGG_FOCAL_ADHESION",0.22127,0.727,0.853,4105,0.993,"PDGFD, LAMA1, VWF, PAK2, FLT4, RAC3, COL4A6, CAV1, PDGFA, BCL2, GRB2, CAV2, EGFR, BAD, PIK3CA, PIK3R2, ITGB4, LAMC2, ITGA2, DIAPH1, PAK6, MAPK9, SPP1, LAMB3, PAK1, MAPK10, CCND2, CCND3, BRAF, ITGA6, ITGA2B, MET, PIK3CB, THBS4, PDGFB, MYL12B, LAMA3, HRAS, IGF1R, PPP1CB, CRKL, LAMA5, MAPK1, MAPK8, PAK4, TNC, SRC, AKT2, COL4A1",0.069050968832477,0.00305075150461883,FALSE +"HCC95","Input","KEGG_FOLATE_BIOSYNTHESIS",0.35829,1.17,0.222,4694,0.654,"DHFR, SPR, GGH",0.653647025549361,0.184422251675733,FALSE +"HCC95","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.36988,1.21,0.198,5217,0.609,"AKR1B10, ALDOC, TPI1, SORD, KHK, MPI, AKR1B1, MTMR1, PFKM, HK1, PFKFB2, MTMR2, ALDOA, FBP2",0.703334809738469,0.215382707367125,FALSE +"HCC95","Input","KEGG_GALACTOSE_METABOLISM",0.26782,0.874,0.637,4310,0.885,"GLA, B4GALT2, GANC, AKR1B1, GAA, GCK, PFKM, GALK2, HK1",0.19586056766465,0.0530567293021746,FALSE +"HCC95","Input","KEGG_GAP_JUNCTION",0.25971,0.86,0.652,4826,0.899,"PDGFD, ADCY3, PDGFA, GRB2, EGFR, PLCB1, ADCY1, PRKACA, GNAI1, ITPR3, HTR2C, LPAR1, TUBAL3, KRAS, PDGFB, HRAS, TUBA4A, MAP2K5, GJA1, TJP1, MAPK1, SRC, PLCB3, TUBB, PDGFC, GUCY1B1, ADCY9",0.18575240426808,0.0462403082667712,FALSE +"HCC95","Input","KEGG_GLIOMA",0.22471,0.746,0.82,4125,0.978,"CALML3, PDGFA, GRB2, EGFR, PIK3CA, PIK3R2, RB1, BRAF, PIK3CB, KRAS, PDGFB, HRAS, IGF1R, MAPK1, AKT2, CAMK2G",0.0861861476162833,0.00966114521239857,FALSE +"HCC95","Input","KEGG_GLUTATHIONE_METABOLISM",0.44028,1.44,0.0744,1394,0.498,"GCLC, GCLM, PGD, GPX2, GSR, G6PD, GPX3, GGCT, GSTM3",1.12842706445412,0.302770657240282,FALSE +"HCC95","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.24477,-0.903,0.571,18025,0.916,"AGPAT4, LIPG, GK, MGLL, ALDH9A1, ALDH7A1",0.243363891754152,0.0381045263321496,FALSE +"HCC95","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.41499,1.36,0.114,3494,0.481,"LPCAT3, DGKH, LCLAT1, PTDSS1, PCYT1A, GNPAT, PCYT2, PCYT1B, PLA2G4B, DGKE, PLD1, PLA2G4A, PLA2G12A, ETNK2, PEMT, PLPP1, CDS1, ETNK1, CDIPT, PLPP2, PGS1, CDS2, AGPAT3, LPCAT2, GPD2, DGKA",0.943095148663527,0.317854923626168,FALSE +"HCC95","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.42973,1.4,0.0889,3249,0.502,"GNMT, AOC2, PIPOX, PSAT1, SHMT1, AOC3, GAMT, GATM, PHGDH, GCAT",1.05109823902979,0.299296282854981,FALSE +"HCC95","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.39925,1.34,0.132,4582,0.508,"ADH7, LDHC, ALDH3A1, ALDOC, TPI1, GAPDH, ACSS1, GPI, ALDH3A2, BPGM, ACSS2, ADH5, DLAT, PGAM4, ALDH2, LDHB, ALDH1A3, PGAM1, GCK, PFKM, HK1, PKM, PCK2",0.87942606879415,0.294136287716081,FALSE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.36743,1.2,0.195,5286,0.606,"B4GALT7, XYLT2, CHST14, CHST7, CHST15, B3GAT3, CHPF, CHSY1, CHST3, CHST12, B3GALT6",0.709965388637482,0.217527375833714,FALSE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.47807,1.57,0.0387,3874,0.48,"HS6ST1, B4GALT7, XYLT2, HS6ST2, HS3ST3B1, GLCE, NDST2, B3GAT3, NDST1, HS3ST3A1",1.41228903498109,0.318758762624413,FALSE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.56397,-2.05,0.00383,14254,0.157,"ST3GAL3, CHST4, CHST2, CHST6, B3GNT7, FUT8, B4GALT4, B4GALT3, ST3GAL1",2.41680122603138,0.804100347590766,TRUE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.38633,1.28,0.15,2073,0.544,"HPSE, HGSNAT, HS3ST3B1, HEXB, NAGLU",0.823908740944319,0.26440110030182,FALSE +"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.44391,1.42,0.11,2469,0.479,"SLC33A1, B4GALNT1, B3GALT4, HEXB, ST6GALNAC4",0.958607314841775,0.319664486585437,FALSE +"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.2793,0.915,0.556,1845,0.858,"GLA, FUT1, HEXB",0.254925208417942,0.0665127121512946,FALSE +"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.33183,-1.24,0.169,14254,0.465,"ST3GAL3, B3GALT2, FUT7, FUT9, FUT3, FUT4, B3GALT1, B3GALT5, ST3GAL6, B3GNT3, B4GALT4, B4GALT3",0.772113295386326,0.332547047110046,FALSE +"HCC95","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.56763,1.85,0.0123,788,0.414,"PIGX, PIGS, PIGW, PIGU, PIGV, PIGN",1.9100948885606,0.382999658879101,FALSE +"HCC95","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.32728,-1.14,0.262,17087,0.595,"GLYCTK, ACO2, ACO1, MTHFD2L, HYI",0.581698708680255,0.22548303427145,FALSE +"HCC95","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.28819,0.943,0.523,4347,0.845,"CALML3, ADCY3, GRB2, EGFR, PLA2G4B, MAPK13, PLCB1, ADCY1, MAPK9, PRKACA, PLD1, ITPR3, PLA2G4A, MAPK10, PLA2G12A, MAPK12, MAP2K6, KRAS, HBEGF, HRAS, MMP14, MAPK1, MAPK8, SRC, CAMK2G, PLCB3, MAPK14, CACNA1D, ATF4, MAPK11",0.281498311132726,0.0731432910503077,FALSE +"HCC95","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.32068,1.04,0.382,4253,0.769,"IL1A, IL1B, KIR2DL3, CD86",0.417936637088291,0.114073660198569,FALSE +"HCC95","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.55523,1.83,0.0096,2277,0.366,"WNT3A, BMP7, WNT5A, WNT8B, GLI2, WNT10A, SMO, WNT7B, WNT11, FBXW11, WNT10B, WNT9A, PTCH1, WNT7A, WNT16, PRKACA, WNT4, CSNK1A1",2.01772876696043,0.436518914605589,FALSE +"HCC95","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.19165,0.634,0.963,3166,0.994,"CD44, IL1A, CD1D, TFRC, CD9, ITGA2, ITGA6, IL1B, CD1E, ITGA2B, CD8A, GP1BA",0.0163737128754655,0.00261361560268669,FALSE +"HCC95","Input","KEGG_HISTIDINE_METABOLISM",0.2761,0.892,0.589,1399,0.859,"ALDH3A1, BUD23, METTL2B, ALDH3A2",0.229884705212898,0.0660068361687577,FALSE +"HCC95","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.46057,1.47,0.0726,3916,0.509,"SEM1, RAD51, EME1, POLD2, XRCC3, RPA3, BLM, SSBP1, RPA1, RAD51B, RAD51C, RAD51D, XRCC2",1.13906337929991,0.293282217663241,FALSE +"HCC95","Input","KEGG_HUNTINGTONS_DISEASE",0.20404,0.669,0.928,2542,0.999,"HAP1, VDAC3, POLR2H, NDUFB5, NDUFB7, POLR2J, AP2M1, VDAC2, NRF1, NDUFS6, AP2B1, ATP5MC1, ATP5PD, PLCB1, POLR2G, NDUFA9, SIN3A, COX5A, TAF4B, CLTCL1, NDUFV2, NDUFB10, NDUFA4L2",0.0324520237811379,0.000434511774017692,FALSE +"HCC95","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.21308,-0.777,0.737,14891,0.993,"SGCD, LAMA2, LMNA, SGCA, PRKAB1, TNNC1, CACNB2, DES, RYR2, ITGA9, CACNA2D1, ITGA10, ITGB7, ITGB5, CACNA1C, DMD, CACNA2D4, CACNG6, CACNG8, PRKAA2, ITGA7, ITGA1, ACE, ITGB3, ITGB1, ACTB, TGFB3, TPM2",0.132532512140949,0.00305075150461883,FALSE +"HCC95","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.21705,-0.789,0.735,17006,0.996,"ALDH6A1, PIK3C2A, PIP5K1C, PI4KA, SYNJ1, INPPL1, PIK3C3, PIP4K2A, PIP5K1A, PI4KB",0.133712660915805,0.00174066157630127,FALSE +"HCC95","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.29416,0.954,0.5,4615,0.867,"CALML3, PRKCI, ACACA, EIF4EBP1, IKBKB, GRB2, SREBF1, BAD, PIK3CA, PIK3R2, PHKB, IRS1, MAPK9, PRKACA, SOCS1, MAPK10, FLOT2, SLC2A4, FOXO1, RHEB, BRAF, PRKAA1, CBLC, FASN, PIK3CB, KRAS, EXOC7, HRAS, PHKA1, ACACB, PPP1CB, CRKL, PRKAG2, SH2B2, RPTOR, MAPK1, MAPK8, GCK, AKT2, PYGL, HK1, PRKCZ, PTPN1, PCK2, RAPGEF1",0.301029995663981,0.0619809025237897,FALSE +"HCC95","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.18783,-0.688,0.919,11300,1,"CD80, PIGR, TNFSF13, IL4, AICDA, IL10, CCR9, CCL25, TNFRSF13C, IL6, CXCL12, IL5, CCR10, ITGB7, TNFSF13B, CXCR4, IL15, CCL28",0.0366844886138887,0,FALSE +"HCC95","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.20593,-0.755,0.817,16363,1,"PIK3R3, PIK3R1, CSF2RA, IL3RA, CNTF, SOS1, IL15, IL11RA, STAT1, IL6ST, PIAS3, SPRY4, JAK2, LIF, SPRY2, SPRY3, IL11, STAM, JAK1, SOCS4, CLCF1, TYK2, IRF9, SOS2, STAT2, STAT5A",0.0877779434675845,0,FALSE +"HCC95","Input","KEGG_LEISHMANIA_INFECTION",0.24501,0.806,0.742,4896,0.949,"TRAF6, IL1A, PTPN6, MAPK13, MAPK12, NFKBIB, NOS2, IL1B, MAP3K7, FOS, TGFB2, MAPK1, MAPK14, PTGS2, MAPK11, NCF2, IL12A, ITGB2",0.129596094720973,0.0227337875727074,FALSE +"HCC95","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.2144,-0.828,0.72,13995,0.988,"ESAM, VAV3, VCL, CXCL12, CLDN14, CTNNA2, CLDN2, CDH5, MYL5, ARHGAP5, CLDN15, VCAM1, PRKCG, RAPGEF3, PLCG1, CLDN10, JAM2, CYBB, PIK3R3, PIK3R1, CXCR4, CLDN9, GNAI3, RHOA, MYLPF, ROCK1, AFDN, EZR, TXK, CD99, CDC42, ITGB1, CLDN23, ACTB, PRKCA, BCAR1, RAP1B, RAP1A, MYL9, ICAM1, ROCK2, VASP, CYBA",0.142667503568732,0.00524305541237188,FALSE +"HCC95","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.45478,-1.69,0.0278,18062,0.514,"YOD1, ALDH9A1, ALDH7A1",1.55595520408192,0.289036881004724,FALSE +"HCC95","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.27548,0.896,0.576,2278,0.858,"AKR1B10, PLA2G4B, PLA2G4A, PLA2G12A",0.239577516576788,0.0665127121512946,FALSE +"HCC95","Input","KEGG_LONG_TERM_DEPRESSION",0.22976,0.776,0.798,3896,0.983,"PPP2CA, NOS1, GNA13, PLA2G4B, PLCB1, LYN, GNAI1, ITPR3, PLA2G4A, PLA2G12A, BRAF, KRAS, HRAS, IGF1R, GNAZ, MAPK1, PPP2R1B",0.0979971086492706,0.00744648216786438,FALSE +"HCC95","Input","KEGG_LONG_TERM_POTENTIATION",0.20946,0.692,0.907,4481,1,"CALML3, PPP3R2, PLCB1, ADCY1, CAMK4, PRKACA, ITPR3, RPS6KA1, BRAF, KRAS, HRAS, PPP1CB, MAPK1, CAMK2G, PLCB3, ATF4, CHP1",0.0423927129399047,0,FALSE +"HCC95","Input","KEGG_LYSINE_DEGRADATION",0.2755,0.906,0.55,3357,0.871,"NSD3, EHHADH, PIPOX, ALDH3A2, NSD1, HADHA, EHMT2, NSD2, ACAT2, SETDB2, ALDH2",0.259637310505756,0.0599818449923368,FALSE +"HCC95","Input","KEGG_LYSOSOME",0.21187,0.695,0.908,5662,1,"PSAPL1, AP3M2, SLC11A1, M6PR, ARSG, CTSV, LAMP3, AP3B1, GLA, HGSNAT, AP1S1, HEXB, LIPA, NAGLU, CLTCL1, GM2A, CD68, NAGPA, CTSH, AP3B2, GNPTAB, LAMP1, CLN5, AP3M1, PPT1, ATP6V0A2, AP1S3, NPC1, GAA, DNASE2, AP1M2, ATP6V0C, LAPTM4B, ABCA2, CTSZ, HEXA, NAGA, GGA2, CLTB, ATP6AP1, NPC2, CTSB, CLTC, PPT2, CTSF, LGMN, CTSL",0.0419141514789149,0,FALSE +"HCC95","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.27399,0.896,0.616,3498,0.858,"TRAF6, NTRK2, MAP3K13, MAP4K1, PAK2, NTF4, FGFR2, RAC3, IL1A, CACNA2D3, NF1, HSPB1, PPP3R2, NLK, FGFR3, IKBKB, PDGFA, DUSP14, GRB2, HSPA1B, NGF, CACNG4, EGFR, PLA2G4B, MAPK13, GADD45G, MAPK9, PPM1B, PRKACA, MYC, PAK1, PLA2G4A, FGF1, MAPK10, PLA2G12A, SRF, CACNB1, DAXX, MAPK12, MAP2K6, DUSP9, RPS6KA1, BRAF, FGF12, DUSP3, IL1B, JUND, ARRB2, MAP3K7, RPS6KA5, CACNA1B, KRAS, PDGFB, FOS, HRAS, TAOK1, RPS6KA4, MAP2K5, CRKL",0.210419287835575,0.0665127121512946,FALSE +"HCC95","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26424,0.862,0.639,4735,0.903,"MAFA, ONECUT1, HHEX, MNX1, GCK, FOXA2, HES1",0.1944991418416,0.0443122496864942,FALSE +"HCC95","Input","KEGG_MELANOGENESIS",0.43383,1.42,0.0828,2279,0.479,"CALML3, WNT3A, FZD1, ADCY3, WNT5A, WNT8B, FZD10, DVL3, WNT10A, POMC, WNT7B, EDN1, WNT11, WNT10B, FZD9, PLCB1, WNT9A, ADCY1, WNT7A, WNT16, PRKACA, GNAI1, WNT4, LEF1",1.08196966321512,0.319664486585437,FALSE +"HCC95","Input","KEGG_MELANOMA",0.27659,0.918,0.542,3418,0.869,"PDGFD, PDGFA, EGFR, BAD, PIK3CA, PIK3R2, RB1, FGF1, CDH1, BRAF, FGF12, MET, PIK3CB, KRAS, PDGFB, HRAS, IGF1R",0.266000713461613,0.0609802235513335,FALSE +"HCC95","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.53409,1.74,0.0201,1394,0.354,"ADH7, AKR1C2, ALDH3A1, AKR1C1, DHDH, AKR1C3, CYP2S1, CYP1B1, EPHX1, UGT2B17, GSTM3",1.69680394257951,0.450996737974212,FALSE +"HCC95","Input","KEGG_MISMATCH_REPAIR",0.58449,1.92,0.00833,4009,0.387,"RFC4, RFC2, PMS2, MSH6, PCNA, POLD2, RFC3, RPA3, SSBP1, RPA1, RFC5, EXO1",2.07935499859321,0.412289034981089,FALSE +"HCC95","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.30304,1,0.422,4169,0.788,"EIF4EBP1, DDIT4, PIK3CA, PIK3R2, ULK2, RHEB, RPS6KA1, BRAF, PRKAA1, PIK3CB, EIF4B, RPTOR, MAPK1, AKT2, MLST8",0.374687549038326,0.103473782510445,FALSE +"HCC95","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.1681,0.562,0.99,3348,1,"SYK, RAC3, PPP3R2, ULBP1, MICB, PTPN6, GRB2, PIK3CA, PIK3R2, NFATC1, PAK1, MICA, TNFSF10, BRAF, LCK, BID, PIK3CB, KRAS, KIR2DL3, HRAS, ULBP3",0.00436480540245009,0,FALSE +"HCC95","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.13459,0.44,1,2847,1,"P2RY1, ADRA2C, GABRB3, S1PR5, CHRNA7, CHRNB4, ADRA1A, CHRNA5, SSTR5, VIPR1, LPAR2, ADORA2B, PTAFR, ADRB2, MTNR1A, GRM4, P2RY13, CHRM3, TACR1, P2RY2, LPAR6, PTH2R, HTR2C, NMUR2, F2RL2, LPAR1",0,0,FALSE +"HCC95","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.32583,1.07,0.321,4347,0.736,"CALML3, TRAF6, NTRK2, NTF4, YWHAG, NGFR, TP73, IKBKB, BCL2, GRB2, NGF, BAD, PIK3CA, PIK3R2, MAPK13, IRS1, CAMK4, MAPK9, MAPK10, MAPK12, NFKBIB, RPS6KA1, BRAF, PIK3CB, RPS6KA5, KRAS, HRAS, RPS6KA4, MAP2K5, CRKL, SH2B2, MAPK1, MAPK8, AKT2, CAMK2G, MAPK14, ATF4, MAPK11",0.493494967595128,0.133122185662501,FALSE +"HCC95","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.37484,-1.33,0.142,16890,0.477,"AOX1, NMNAT2, NMNAT1, NT5E, NNT, NNMT, QPRT",0.847711655616944,0.321481620959886,FALSE +"HCC95","Input","KEGG_NITROGEN_METABOLISM",0.38858,1.28,0.161,1305,0.544,"GLS2, GLUL, ASNS",0.79317412396815,0.26440110030182,FALSE +"HCC95","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.33633,1.11,0.291,4347,0.717,"TRAF6, HSP90AB1, CASP1, IKBKB, MAPK13, MAPK9, MAPK10, TRIP6, MAPK12, NFKBIB, IL1B, PYCARD, MAP3K7, MAPK1, MAPK8, SUGT1, IL18, MAPK14, MAPK11",0.536107011014093,0.1444808443322,FALSE +"HCC95","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.40163,-1.43,0.087,16335,0.404,"POLM, RAD50, NHEJ1, DCLRE1C, LIG4",1.06048074738138,0.393618634889395,FALSE +"HCC95","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.20338,-0.744,0.789,14914,1,"MAP2K2, PRKCG, PLCG1, TP53, E2F3, PIK3R3, PIK3R1, SOS1, RAF1, FHIT, PRKCA, CDKN2A, SOS2, RASSF1, ARAF",0.10292299679058,0,FALSE +"HCC95","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.23284,0.759,0.803,4735,0.98,"DLL1, DVL3, JAG2, MAML1, KAT2A, DLL3, JAG1, DVL2, DTX2, ADAM17, NOTCH1, HDAC1, MFNG, NUMBL, LFNG, HES1",0.095284454721319,0.00877392430750515,FALSE +"HCC95","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.42598,1.39,0.117,3688,0.485,"RFC4, RAD23B, RFC2, GTF2H4, PCNA, POLE2, XPA, POLD2, POLE3, RFC3, RPA3, GTF2H3, RPA1, ERCC3, ERCC8, RFC5",0.931814138253838,0.314258261397736,FALSE +"HCC95","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.42909,1.42,0.074,4377,0.479,"ALG3, ALG12, MOGS, DOLPP1, MGAT1, B4GALT2, TUSC3, ALG2, ALG1, ALG14, DPAGT1, GANAB, DPM1, STT3A, RFT1, MGAT4B, ALG5, ALG11, MAN1B1, ALG10B, MGAT2, RPN2",1.13076828026902,0.319664486585437,FALSE +"HCC95","Input","KEGG_OLFACTORY_TRANSDUCTION",0.33325,1.1,0.307,458,0.731,"OR10S1, CALML3, OR11H4, OR8A1, OR8G1, OR1G1, OR10H2, OR8D2, OR6C70, ADCY3, OR8G5",0.512861624522813,0.13608262304214,FALSE +"HCC95","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.30475,1.01,0.418,5546,0.783,"MTFMT, TYMS, SHMT1, DHFR, MTHFD2, SHMT2, MTHFD1L, GART, MTHFD1",0.378823718224965,0.106238237942057,FALSE +"HCC95","Input","KEGG_OOCYTE_MEIOSIS",0.26634,0.875,0.609,4187,0.891,"CALML3, ADCY3, YWHAG, PPP3R2, ANAPC1, PPP2CA, CCNB2, FBXW11, PPP2R5D, ANAPC11, ADCY1, PRKACA, ITPR3, CDC23, MAPK12, CUL1, RPS6KA1, BUB1, CDC26, PKMYT1, CDC25C, IGF1R, PPP1CB, PTTG1, MAD2L2, MAPK1, PPP2R1B, CAMK2G, ANAPC7",0.215382707367125,0.0501222959631252,FALSE +"HCC95","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.34108,-1.21,0.163,13292,0.489,"FUCA2, MAN2C1, NEU4, GLB1, FUCA1, NEU1, GBA, AGA, MAN2B1, MANBA",0.787812395596042,0.31069114087638,FALSE +"HCC95","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.20225,0.661,0.925,6278,1,"ATP6V1C2, ATP6V1E2, NDUFB5, NDUFB7, NDUFS6, ATP5MC1, ATP5PD, NDUFA9, COX5A, NDUFV2, NDUFB10, NDUFA4L2, COX10, COX11, LHPP, UQCRFS1, SDHD, NDUFA2, ATP6V0A2, ATP5MG, SDHA, ATP6V1G2, NDUFS4, NDUFA8, COX7C, ATP6V0C, COX5B, ATP6V0E2, CYC1, UQCRHL, NDUFV1, ATP5PO, UQCRC1, COX8A, ATP6AP1, ATP5F1A, NDUFA10, UQCRQ, PPA1, NDUFB8, ATP12A, ATP5MF, COX15, NDUFB9, NDUFB2, COX7A2L, ATP6V0A1, ATP5MC3",0.0338582672609674,0,FALSE +"HCC95","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.35234,1.15,0.259,2264,0.677,"GCNT1, GALNT11, GALNT18, GALNT13, GALNT14, GALNT12",0.586700235918748,0.169411331314856,FALSE +"HCC95","Input","KEGG_P53_SIGNALING_PATHWAY",0.31099,1.02,0.392,977,0.788,"TP53AIP1, SESN3, SERPINB5, TP73, EI24, CCNB2, SFN",0.406713932979543,0.103473782510445,FALSE +"HCC95","Input","KEGG_PANCREATIC_CANCER",0.28446,0.92,0.523,5488,0.874,"RAC3, IKBKB, RALBP1, RAD51, EGFR, BAD, PIK3CA, PIK3R2, MAPK9, PLD1, RB1, MAPK10, BRAF, PIK3CB, KRAS, TGFB2, MAPK1, MAPK8, AKT2, SMAD2, TGFBR1, TGFA, CCND1, RAC1, ERBB2, VEGFC, IKBKG, E2F2",0.281498311132726,0.058488567365597,FALSE +"HCC95","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.3738,1.24,0.178,3596,0.592,"COASY, PANK2, PPCDC, PANK3, BCAT1, BCAT2",0.749579997691106,0.22767829327708,FALSE +"HCC95","Input","KEGG_PARKINSONS_DISEASE",0.19697,0.653,0.938,2542,0.993,"VDAC3, SNCAIP, NDUFB5, NDUFB7, SNCA, VDAC2, NDUFS6, ATP5MC1, ATP5PD, UCHL1, NDUFA9, COX5A, NDUFV2, NDUFB10, NDUFA4L2",0.0277971616209356,0.00305075150461883,FALSE +"HCC95","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.41106,-1.52,0.0742,16465,0.412,"YWHAQ, ARPC3, CD14, RHOA, ARPC4, TLR4, TUBA1A, ROCK1, EZR, TUBA8, CDC42, ITGB1, ACTB, PRKCA, TUBB2B, TUBB2A, ROCK2, ARHGEF2",1.12959609472097,0.385102783966865,FALSE +"HCC95","Input","KEGG_PATHWAYS_IN_CANCER",0.30119,1.01,0.411,3708,0.783,"TRAF6, WNT3A, LAMA1, FZD1, FGFR2, RAC3, WNT5A, WNT8B, GLI2, COL4A6, FZD10, DVL3, WNT10A, HSP90AB1, SMO, WNT7B, FGFR3, IKBKB, WNT11, PDGFA, BCL2, GRB2, RALBP1, SKP2, RAD51, WNT10B, EGFR, BAD, PIK3CA, JUP, RXRA, PIK3R2, FZD9, LAMC2, WNT9A, MSH6, AXIN1, ITGA2, PTCH1, WNT7A, WNT16, MAPK9, CEBPA, MYC, LAMB3, PLD1, WNT4, RB1, FGF1, MAPK10, LEF1, GSTP1, FOXO1, CDH1, BCR, BRAF, FGF12, ITGA6, NOS2, CBLC, FZD6, BID, ITGA2B, MET, SLC2A1, PIK3CB, CCNA1, DVL2, KRAS, PDGFB, PML, FOS, TRAF4, LAMA3, HRAS, IGF1R, CRKL, ARNT2, TGFB2, BIRC5, LAMA5, EGLN3",0.386158178123931,0.106238237942057,FALSE +"HCC95","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.46084,1.52,0.0518,4360,0.488,"DHDH, DCXR, UGT2B17, AKR1B1, UGDH, RPEL1",1.28567024025477,0.311580177997289,FALSE +"HCC95","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.50449,1.66,0.036,1720,0.42,"ALDOC, PGD, G6PD, TKT, TALDO1, GPI, PGLS, DERA",1.44369749923271,0.3767507096021,FALSE +"HCC95","Input","KEGG_PEROXISOME",0.33945,1.11,0.288,2716,0.717,"CAT, ACSL6, PEX6, EHHADH, GNPAT, PRDX1, SLC27A2, PEX11G, PEX5, PIPOX, PXMP2, EPHX2, PEX2, PAOX, PEX10, ACSL3, CROT, NOS2",0.540607512240769,0.1444808443322,FALSE +"HCC95","Input","KEGG_PHENYLALANINE_METABOLISM",0.44089,1.47,0.0665,2780,0.509,"ALDH3A1, AOC2, GOT2, AOC3, GOT1",1.1771783546969,0.293282217663241,FALSE +"HCC95","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25236,0.833,0.676,3123,0.917,"CALML3, DGKH, PIK3CA, PIK3R2, PLCB1, DGKE, PIP4K2B, IMPA2, ITPR3, IPPK, PLCD1, CDS1, CDIPT, PIK3CB, CDS2",0.170053304058364,0.0376306643299789,FALSE +"HCC95","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.25238,-0.932,0.52,18193,0.94,"CPOX, UROD, HMOX1, PPOX, HCCS",0.283996656365201,0.0268721464003014,FALSE +"HCC95","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.31381,1.04,0.371,3022,0.769,"ACSL6, ME1, SCD, EHHADH, FADS2, OLR1, SLC27A2, PLTP, RXRA, CPT1A, SLC27A5, ACSL3, FABP6, SCD5, SLC27A6",0.430626090384954,0.114073660198569,FALSE +"HCC95","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.42226,-1.53,0.0579,15755,0.463,"CYP46A1, CYP7B1, CYP27A1, ACOX2, HSD3B7, SCP2",1.23732143627256,0.334419008982047,FALSE +"HCC95","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.54243,1.77,0.0173,3590,0.353,"RAG1, RAG2, RFXANK, UNG, ADA, TAP2, RFXAP, LCK, CD8A, TAP1, CD40",1.7619538968712,0.452225294612177,FALSE +"HCC95","Input","KEGG_PRION_DISEASES",-0.19563,-0.691,0.905,15964,1,"NCAM2, CCL5, PRKACB, NCAM1, C8G, HSPA1A, ELK1",0.0433514207947967,0,FALSE +"HCC95","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.35234,1.15,0.244,4415,0.677,"ADCY3, HSP90AB1, ANAPC1, CCNB2, PIK3CA, PIK3R2, MAPK13, ANAPC11, ADCY1, MAPK9, PRKACA, GNAI1, MAPK10, CDC23, MAPK12, RPS6KA1, BRAF, BUB1, PIK3CB, CDC26, CCNA1, PKMYT1, KRAS, CDC25C, IGF1R, CCNA2, MAD2L2, MAPK1, MAPK8, AKT2, ANAPC7, MAPK14, MAPK11, CDC27",0.612610173661271,0.169411331314856,FALSE +"HCC95","Input","KEGG_PROPANOATE_METABOLISM",0.31198,1.03,0.389,3769,0.773,"LDHC, EHHADH, ACACA, ACSS1, ALDH3A2, PCCB, ACSS2, HADHA, ACAT2, ALDH2, ACACB, LDHB",0.410050398674292,0.111820506081675,FALSE +"HCC95","Input","KEGG_PROSTATE_CANCER",0.28298,0.934,0.524,3418,0.858,"PDGFD, FGFR2, HSP90AB1, IKBKB, PDGFA, BCL2, GRB2, EGFR, BAD, PIK3CA, PIK3R2, RB1, LEF1, GSTP1, FOXO1, BRAF, PIK3CB, KRAS, PDGFB, HRAS, IGF1R",0.280668713016273,0.0665127121512946,FALSE +"HCC95","Input","KEGG_PROTEASOME",0.41552,1.36,0.112,5428,0.481,"PSMD11, PSMD2, SEM1, PSME3, PSMC5, PSMD12, PSMD3, PSMC2, PSMA4, PSMB3, PSMD8, PSMF1, PSME4, PSMC1, PSMB9, PSMA7, PSMB6, PSMB8, PSMB10, PSMA2, PSMD7",0.950781977329818,0.317854923626168,FALSE +"HCC95","Input","KEGG_PROTEIN_EXPORT",-0.29128,-1.05,0.384,17904,0.729,"SRPRB, SEC61A2, SEC63, SEC61A1",0.415668775632469,0.137272471682025,FALSE +"HCC95","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.47173,1.53,0.0629,2389,0.499,"GLS2, SLC9A3, ATP1B3, SLC25A10, MDH1, ATP1A1",1.20134935455473,0.30189945437661,FALSE +"HCC95","Input","KEGG_PURINE_METABOLISM",0.23092,0.756,0.794,5795,0.977,"ADCY10, POLR2H, GMPS, ADCY3, IMPDH1, NME2, POLR2J, POLR1D, ADA, ADK, AK7, ADCY1, POLR2G, HPRT1, POLE2, POLD2, POLE3, POLR3G, PRIM1, PAICS, NT5C, POLR1B, POLA2, POLR2D, PDE8B, NT5M, PFAS, ITPA, PRIM2, ENTPD2, PKM, PDE9A, POLR3F, NME3, GUCY1B1, POLR2J2, ADCY9, NME1, ENTPD6, POLR1C, POLR2I, PPAT, POLD1, POLR2C, GART, CANT1, POLD3, POLR3GL, POLR2F, RRM1, AK4",0.100179497572904,0.0101054362812269,FALSE +"HCC95","Input","KEGG_PYRIMIDINE_METABOLISM",0.27634,0.902,0.555,5758,0.862,"POLR2H, TK1, NME2, POLR2J, POLR1D, TXNRD1, TYMS, POLR2G, CAD, POLE2, POLD2, POLE3, POLR3G, DUT, PRIM1, NT5C, POLR1B, POLA2, POLR2D, NT5M, DTYMK, ITPA, PRIM2, DHODH, POLR3F, UPP1, NME3, POLR2J2, NME1, ENTPD6, POLR1C, POLR2I, POLD1, POLR2C, DCTD, CANT1, POLD3, POLR3GL, POLR2F, RRM1",0.255707016877324,0.0644927341752872,FALSE +"HCC95","Input","KEGG_PYRUVATE_METABOLISM",0.33581,1.09,0.314,3776,0.708,"LDHC, ME1, ACACA, ACSS1, ALDH3A2, MDH2, MDH1, ACSS2, DLAT, ACAT2, AKR1B1, ALDH2, ACACB, LDHB, GLO1",0.503070351926785,0.149966742310231,FALSE +"HCC95","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.19717,0.657,0.925,5149,0.997,"PDGFD, PAK2, FGFR2, RAC3, FGFR3, GIT1, FGD3, ENAH, PDGFA, GNA13, PFN2, EGFR, ARPC2, PIK3CA, PIK3R2, ITGB4, ITGA2, PIP4K2B, DIAPH1, PAK6, PAK1, FGF1, CHRM3, BRAF, FGF12, ITGA6, MYH14, ITGA2B, PIK3CB, KRAS, PDGFB, MYL12B, CYFIP1, HRAS, PPP1CB, CRKL, IQGAP2, SSH1, BDKRB2, MAPK1, PAK4, MSN, LIMK1, BDKRB1, MYL2, VAV2, PFN4, ARHGEF4, PDGFC, ITGB8, ITGAE, BAIAP2, ITGB2, FGFR4, ITGA3, SSH3, RAC1, ARHGAP35, MYH10, ITGB6",0.0338582672609674,0.00130484168834428,FALSE +"HCC95","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.35227,-1.28,0.153,16573,0.49,"ATG4C, PRKAA2, ATG4A, ULK3, GABARAP, ATG7, ATG4B, PIK3C3, PIK3R4, ATG3",0.815308569182401,0.309803919971486,FALSE +"HCC95","Input","KEGG_RENAL_CELL_CARCINOMA",0.22785,0.753,0.81,4107,0.975,"PAK2, GRB2, PIK3CA, PIK3R2, PAK6, PAK1, BRAF, MET, SLC2A1, PIK3CB, KRAS, PDGFB, HRAS, CRKL, ARNT2, TGFB2, EGLN3, MAPK1, PAK4, AKT2, ELOC",0.0915149811213502,0.0109953843014632,FALSE +"HCC95","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.34171,1.12,0.275,2098,0.716,"CMA1, NLN, LNPEP",0.560667306169737,0.145086977692144,FALSE +"HCC95","Input","KEGG_RETINOL_METABOLISM",0.42286,1.39,0.0886,197,0.485,"ADH7, RDH16, CYP26A1",1.05256627811295,0.314258261397736,FALSE +"HCC95","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.40067,-1.49,0.0615,14086,0.356,"FLAD1, ACP4, PHPT1, ACP5, ACP2, ACP1",1.21112488422458,0.448550002027125,FALSE +"HCC95","Input","KEGG_RIBOSOME",0.40256,1.33,0.125,4872,0.511,"RPL35A, RPS2, RPL12, RPLP1, RPL38, RPS17, RPL37, RPL13, RPL18A, RPS10, RPL23A, RPL27, RPL26L1, RPL22, RPS21, RPS16, RPL31, RPL22L1, RSL24D1, RPL26, RPL23, RPS18, RPL4, RPL8, RPL17, RPL19, RPS27A, RPL21, RPL7A, RPL10A, RPL3L, RPL35, FAU, RPS24, RPS23, UBA52, RPLP0, RPS3",0.903089986991944,0.291579099865287,FALSE +"HCC95","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.21245,0.69,0.898,4347,1,"TRAF6, IKBKB, MAPK13, MAPK9, MAPK10, NLRX1, MAPK12, NFKBIB, TKFC, MAVS, MAP3K7, ATG5, MAPK8, TRADD, MAPK14, MAPK11",0.0467236633326956,0,FALSE +"HCC95","Input","KEGG_RNA_DEGRADATION",0.31295,1.04,0.376,3669,0.769,"LSM1, LSM4, LSM2, CNOT6, CNOT1, EXOSC8, EDC3, TENT4A, EXOSC2, EXOSC1, CNOT8, WDR61, HSPA9, XRN2, DCP2, LSM6, CNOT9",0.424812155072339,0.114073660198569,FALSE +"HCC95","Input","KEGG_RNA_POLYMERASE",0.41478,1.36,0.103,5730,0.481,"POLR2H, POLR2J, POLR1D, POLR2G, POLR3G, POLR1B, POLR2D, POLR3F, POLR2J2, POLR1C, POLR2I, POLR2C, POLR3GL, POLR2F",0.987162775294828,0.317854923626168,FALSE +"HCC95","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.38287,1.27,0.156,1510,0.553,"BUD23, METTL2B, MAT2B, AHCY",0.806875401645538,0.257274868695302,FALSE +"HCC95","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.33346,1.09,0.316,5488,0.708,"TRAF6, LAMA1, COL4A6, IKBKB, BCL2, SKP2, PIK3CA, RXRA, PIK3R2, LAMC2, ITGA2, MYC, LAMB3, RB1, ITGA6, NOS2, ITGA2B, PIK3CB, TRAF4, LAMA3, LAMA5, AKT2, COL4A1, PTGS2, PTEN, CDKN1B, TRAF3, CCND1, PIAS2, ITGA3, COL4A4, ITGAV, IKBKG, COL4A2, E2F2",0.500312917381596,0.149966742310231,FALSE +"HCC95","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.22491,-0.807,0.726,15588,1,"SNAP29, SNAP25, VTI1B, STX1A, BET1L, STX11, STX7, STX2, STX4, STX1B, VAMP5, SEC22B, STX12",0.139063379299906,0,FALSE +"HCC95","Input","KEGG_SPHINGOLIPID_METABOLISM",0.2859,0.948,0.512,3379,0.863,"SPTLC1, UGT8, GLA, KDSR, PLPP1, ACER3, PLPP2, SMPD4, ASAH2",0.290730039024169,0.0639892042847904,FALSE +"HCC95","Input","KEGG_SPLICEOSOME",0.36969,1.23,0.175,4681,0.575,"THOC3, NCBP2, DHX8, PPIL1, WBP11, LSM4, LSM2, TRA2B, SNRPE, NCBP1, HSPA1B, U2SURP, ZMAT2, CHERP, EFTUD2, DHX16, PRPF19, SF3B6, THOC1, SNRPC, SNRPB, ALYREF, EIF4A3, SART1, MAGOHB, DDX46, SRSF2, CDC5L, SNRPG, USP39, CRNKL1, AQR, CTNNBL1, SRSF8, TXNL4A, SNRNP200, PRPF4, DDX42, HNRNPA3, LSM6, PRPF6, PHF5A, HNRNPK, SRSF3, SNRPA, SRSF1, SNRNP40, HNRNPM, SNU13, SNRPD1, SRSF7, BUD31, SNRPF, HSPA2, SLU7",0.756961951313706,0.24033215531037,FALSE +"HCC95","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.17776,-0.657,0.974,14597,0.985,"HK3, GBE1, PYGM, TREH, UGT2B7, GYS1, HK2, PGM2L1, PGM1, AMY2B",0.0114410431213845,0.00656376950238827,FALSE +"HCC95","Input","KEGG_STEROID_BIOSYNTHESIS",0.59816,1.97,0.0095,4575,0.444,"CYP51A1, FDFT1, DHCR7, LIPA, LSS, SQLE, HSD17B7, NSDHL, TM7SF2, DHCR24, SC5D, CEL",2.02227639471115,0.35261702988538,FALSE +"HCC95","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.45133,1.46,0.0729,1244,0.504,"AKR1C2, AKR1C1, SRD5A1, AKR1C3, HSD17B8, CYP1B1, UGT2B17",1.13727247168203,0.297569463554475,FALSE +"HCC95","Input","KEGG_SULFUR_METABOLISM",-0.36818,-1.34,0.132,16790,0.504,"SULT2B1, CHST11, PAPSS2",0.87942606879415,0.297569463554475,FALSE +"HCC95","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.22706,-0.806,0.71,11300,0.985,"CD80, C6, C9, ACTN2, C2, IL10, FCGR2B, FCGR2C, C7, SSB, C3, CTSG, TNF, GRIN2B, FCGR1A, ELANE, FCGR2A, TRIM21, C4A, C8G, C4B",0.148741651280925,0.00656376950238827,FALSE +"HCC95","Input","KEGG_TASTE_TRANSDUCTION",-0.14525,-0.528,0.996,13138,0.996,"TAS2R1, SCNN1G, TAS2R9, TAS2R40, ASIC2, SCNN1B, PDE1A, TAS2R43, PLCB2, TAS1R3, ADCY4, KCNB1, TAS2R10, CACNA1A, GNG13, PRKACB, GNB1, ADCY6",0.00174066157630127,0.00174066157630127,FALSE +"HCC95","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.27527,-1.01,0.379,13917,0.76,"ADO, CDO1, GGT5, CSAD",0.421360790031928,0.119186407719209,FALSE +"HCC95","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.50713,1.67,0.0358,4441,0.444,"HMGCS1, HMGCR, ACAT2, MVK, IDI1",1.44611697335613,0.35261702988538,FALSE +"HCC95","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.18184,-0.672,0.919,16691,1,"RHOA, ZFYVE9, ROCK1, NOG, INHBA, RBX1, ZFYVE16, ACVR2A, TGFB3, CDKN2B, PPP2R1A, ROCK2, THBS3, E2F5",0.0366844886138887,0,FALSE +"HCC95","Input","KEGG_THYROID_CANCER",-0.27302,-1.03,0.363,17381,0.745,"TFG, PAX8, TCF7, PPARG, TCF7L2, TPR",0.440093374963888,0.127843727251707,FALSE +"HCC95","Input","KEGG_TIGHT_JUNCTION",0.28847,0.943,0.514,4552,0.845,"CLDN8, CLDN11, PPP2R2C, PRKCI, YES1, PPP2CA, EPB41L1, YBX3, JAM3, EXOC4, PRKCH, VAPA, GNAI1, CLDN4, CLDN7, CSNK2A2, MYH14, PRKCQ, CRB3, EXOC3, CLDN1, AMOTL1, F11R, KRAS, MYL12B, TJAP1, HRAS, PATJ, CSNK2A1, LLGL2, TJP1, PPP2R1B, SRC, AKT2, PRKCZ, CLDN16, MYL2, PTEN",0.289036881004724,0.0731432910503077,FALSE +"HCC95","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.20404,0.677,0.912,4347,0.998,"TRAF6, IKBKB, PIK3CA, IRF5, PIK3R2, MAPK13, MAPK9, SPP1, MAPK10, MAPK12, MAP2K6, IL1B, TLR6, PIK3CB, MAP3K7, FOS, CD40, MAPK1, MAPK8, AKT2, CD86, MAPK14, MAPK11",0.0400051616715838,0.000869458712628891,FALSE +"HCC95","Input","KEGG_TRYPTOPHAN_METABOLISM",0.32699,1.08,0.317,1664,0.722,"CAT, EHHADH, CYP1B1, ALDH3A2, AFMID, KYNU",0.498940737782249,0.141462802430361,FALSE +"HCC95","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.3788,1.23,0.18,4419,0.575,"IKBKB, MAFA, PIK3CA, PIK3R2, IRS1, MAPK9, SOCS1, MAPK10, SLC2A4, PIK3CB, CACNA1B, MAPK1, MAPK8, GCK, CACNA1D, HK1, PRKCZ, PKM",0.744727494896694,0.24033215531037,FALSE +"HCC95","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.28898,0.945,0.505,4858,0.86,"IL1A, IL1B, GAD1, CD86, IL12A",0.296708621881339,0.0655015487564323,FALSE +"HCC95","Input","KEGG_TYROSINE_METABOLISM",0.48802,1.6,0.0414,2780,0.455,"ADH7, ALDH3A1, BUD23, AOC2, GOT2, METTL2B, AOC3, ADH5, GOT1",1.3829996588791,0.341988603342888,FALSE +"HCC95","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.29421,0.982,0.441,4493,0.805,"DLG1, PAK2, PPP3R2, IKBKB, PTPN6, GRB2, PIK3CA, PIK3R2, MAPK13, PAK6, NCK1, MAPK9, NFATC1, PAK1, MALT1, MAPK12, NFKBIB, LCK, PRKCQ, CBLC, PIK3CB, MAP3K7, CD8A, KRAS, FOS, HRAS, NCK2, MAPK1, PAK4, AKT2, NFATC3, MAPK14, MAPK11, CHP1, VAV2",0.355561410532161,0.0942041196321315,FALSE +"HCC95","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.27263,0.903,0.59,3547,0.868,"TRAF6, UBA2, KLHL13, ANAPC1, FBXW11, FBXO2, UBE3C, UBE2H, HERC2, SKP2, UBE2S, UBE2D2, ANAPC11, UBE2B, PRPF19, TRIM37, BRCA1, SOCS1, CDC23, CUL1, UBE2O, KEAP1, UBE3A, ITCH, CBLC, UBR5, CDC26, RNF7, PML, FBXO4, UBE2Z, FANCL, ERCC8",0.229147988357856,0.0614802748235081,FALSE +"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.44179,-1.66,0.0391,16289,0.434,"LARS2, PDHB, PDHA1",1.40782324260413,0.362510270487489,FALSE +"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.31015,1.03,0.378,3596,0.773,"HMGCS1, EHHADH, AUH, MCCC1, ALDH3A2, PCCB, MCCC2, HADHA, ACAT2, BCAT1, IVD, OXCT1, ALDH2, HADHB, BCAT2",0.422508200162775,0.111820506081675,FALSE +"HCC95","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.20647,0.679,0.907,2730,1,"CALML3, ADCY3, ADRA1A, GNA13, PLA2G4B, PLCB1, ADORA2B, ADCY1, PRKCH, PRKACA, ITPR3, PLA2G4A, PLA2G12A, KCNMB3, BRAF, PRKCQ",0.0423927129399047,0,FALSE +"HCC95","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.29995,-1.09,0.259,16613,0.673,"PRKACB, RAB11B, RAB5B, STX4, ADCY6, CREB3, CREB3L1, DCTN6, DYNC1I2, DYNC1LI1, RAB5A",0.586700235918748,0.171984935776023,FALSE +"HCC95","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.25659,0.852,0.664,4481,0.901,"RAC3, HSPB1, PPP3R2, BAD, PIK3CA, PIK3R2, PLA2G4B, MAPK13, NFATC1, PLA2G4A, PLA2G12A, MAPK12, PIK3CB, KRAS, HRAS, MAPK1, SRC, AKT2, NFATC3, MAPK14, PTGS2, MAPK11, CHP1",0.177831920631982,0.045275209020937,FALSE +"HCC95","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.25168,-0.922,0.529,17767,0.933,"ACTB, PRKCA, KDELR1, ATP6V0B, SEC61A2, ATP6V1D, ATP6V1A, SEC61A1, ATP6V0D1",0.276544327964814,0.0301183562535,FALSE +"HCC95","Input","KEGG_VIRAL_MYOCARDITIS",0.18653,0.629,0.957,924,0.991,"EIF4G1, RAC3, CAV1",0.0190880622231565,0.00392634551472468,FALSE +"HCC95","Input","KEGG_WNT_SIGNALING_PATHWAY",0.39701,1.29,0.133,2533,0.55,"WNT3A, SENP2, TBL1XR1, FZD1, RAC3, WNT5A, WNT8B, SFRP5, FZD10, DVL3, WNT10A, PPP3R2, WNT7B, NLK, PRICKLE1, PPP2CA, WNT11, FBXW11, WNT10B, PPP2R5D, FZD9, PLCB1, WNT9A, AXIN1, WNT7A, VANGL1, WNT16, MAPK9, PRKACA, MYC, NFATC1, WNT4, MAPK10, CSNK1A1, LEF1, CCND2, CCND3, CSNK2A2, CUL1",0.876148359032914,0.259637310505756,FALSE +"H1975","Input","KEGG_ABC_TRANSPORTERS",0.22788,0.708,0.877,2824,0.957,"ABCA1, ABCB8, ABCG2, ABCB9, ABCB7, ABCA3, ABCA7",0.0570004066339595,0.0190880622231565,FALSE +"H1975","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.27617,0.872,0.638,4088,0.887,"RPS6KB2, MAP2K2, CCNA1, MYC, ARAF, PPARD, PIM2, PIK3R2, CHUK, IKBKG, PIK3CA, RARA, STAT5B, MAPK1, PIK3CB",0.195179321278838,0.0520763801682736,FALSE +"H1975","Input","KEGG_ADHERENS_JUNCTION",0.2968,0.929,0.565,6665,0.86,"SNAI1, RAC2, FER, ACTN1, RAC1, ACTB, INSR, MET, SORBS1, CDH1, PTPN1, WASL, MAPK1, RHOA, SNAI2, VCL, EGFR, IQGAP1, CSNK2A1, SMAD4, EP300, SMAD3, TJP1, PTPN6, PTPRF, ACTG1, PARD3, TGFBR1, TGFBR2, NECTIN4, ERBB2, TCF7, NECTIN1, BAIAP2",0.247951552180562,0.0655015487564323,FALSE +"H1975","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.346,-1.3,0.162,17878,1,"MAPK10, PRKCQ, ADIPOR2, PRKAG1, PPARGC1A, JAK2, AKT3, PCK2, PRKAA2, NFKBIB, ADIPOR1, NFKBIE, PRKAB1, AKT2",0.790484985457369,0,FALSE +"H1975","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.29001,0.903,0.588,3808,0.859,"ASL, GFPT2, GLS, GLUD1, GOT2, ASS1, CPS1, ADSL",0.230622673923862,0.0660068361687577,FALSE +"H1975","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.1833,0.577,0.978,4088,0.975,"ATP1A2, INSR, PRKCA, SFN, PIK3R2, FXYD4, IRS1, PIK3CA, MAPK1, PIK3CB",0.00966114521239857,0.0109953843014632,FALSE +"H1975","Input","KEGG_ALLOGRAFT_REJECTION",0.35646,1.11,0.286,2347,0.682,"IL12B, CD40",0.543633966870957,0.166215625343521,FALSE +"H1975","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.22711,-0.869,0.574,12217,1,"PLA2G4E, PLA2G12B, PLA2G2F, PLA2G5, PLA2G2A, ACOX3, PLA2G1B, PLA2G3, PLA2G10, PLA2G4A, PLA2G4B",0.241088107602027,0,FALSE +"H1975","Input","KEGG_ALZHEIMERS_DISEASE",0.28996,0.906,0.597,5115,0.879,"NDUFV1, COX8C, GRIN2A, UQCR11, NDUFS8, CALM1, UQCR10, NDUFA7, ATP5F1B, GRIN1, NDUFB7, COX6B2, BACE1, GRIN2D, NDUFA6, SDHA, FADD, APH1A, NDUFS2, CASP8, NDUFB2, NDUFS7, NDUFA3, SDHC, UQCRC1, ITPR1, ATP5F1D, PSEN1, NDUFB6, NDUFA8, EIF2AK3, CAPN2, HSD17B10, PPP3CA, GSK3B, NAE1, CYCS, MAPK1, COX7B, NDUFA5, APBB1, NDUFV3, ATP2A3, CDK5, NDUFB10, IDE, TNFRSF1A, ITPR3, NDUFA4, PSEN2, NDUFS6, ATF6",0.224025668870631,0.0560111249262281,FALSE +"H1975","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.56287,1.76,0.0171,2635,0.512,"FARS2, FARSA, TARS2, DARS2, LARS2, IARS2, CARS2, EARS2",1.76700388960785,0.290730039024169,FALSE +"H1975","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.43562,1.34,0.11,5221,0.517,"GCK, GFPT2, GNPDA1, GMPPA, CYB5R3, HK2, RENBP, GMPPB, NANP, GALK1, PGM2, AMDHD2, NANS, UAP1, UGDH, HEXB, HK1, NAGK, PMM1, GNPNAT1, UGP2",0.958607314841775,0.286509456906058,FALSE +"H1975","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.28289,0.872,0.651,3910,0.887,"CCS, GRIN2A, GRIN1, TP53, GRIN2D, RAC1, TOMM40L, GPX1, MAPK12, CAT, PPP3CA, CYCS, MAPK13",0.186419011431808,0.0520763801682736,FALSE +"H1975","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.33851,1.04,0.356,5574,0.78,"HSP90AA1, LGMN, CIITA, KLRC1, IFI30, CD74, HSPA1A, CTSL, HSPA2, NFYA, HSPA1B, HSPA8, KIR2DL1, CTSS, CTSB, TAP2, PSME1, CALR, CREB1, RFXANK, RFX5, PSME2, PSME3",0.448550002027125,0.10790539730952,FALSE +"H1975","Input","KEGG_APOPTOSIS",0.24908,0.782,0.747,4699,0.955,"PRKAR1B, IL1RAP, TP53, ENDOD1, AIFM1, FADD, IRAK1, TRADD, CASP8, CASP10, IL1R1, IRAK4, PRKACA, PIK3R2, XIAP, CHUK, IKBKG, PRKAR2A, PIK3CA, CAPN2, PPP3CA, MYD88, CYCS, PIK3CB, RIPK1, DFFA, TNFRSF1A",0.126679398184601,0.0199966284162537,FALSE +"H1975","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.32602,1.01,0.422,2668,0.797,"CYP2C9, CYP2E1, GPX4, CYP2C8, PLA2G2C, PTGES2, PTGES, GPX3, GPX1",0.374687549038326,0.0985416786038876,FALSE +"H1975","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.4526,1.41,0.0762,3980,0.487,"NOS3, ASL, ALDH9A1, SAT2, SMS, GLS, OAT, GLUD1, MAOB, ALDH1B1, GOT2, P4HA1, P4HA3, ASS1, SRM, NAGS, CPS1, MAOA",1.1180450286604,0.312471038785366,FALSE +"H1975","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.25699,-0.993,0.437,15938,1,"CACNG7, ITGA7, SGCD, ITGA9, ACTN2, CACNA2D3, CACNA2D4, CACNB4, CACNA1C, RYR2, LAMA2, CACNA1D, ITGA4, ATP2A2, SLC8A1, DMD, LEF1, PKP2, CACNA2D1, ITGB8, CDH2",0.359518563029578,0,FALSE +"H1975","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.31672,0.984,0.468,4264,0.816,"ALDH9A1, ALDH1B1, UGDH",0.329754146925876,0.0883098412461389,FALSE +"H1975","Input","KEGG_ASTHMA",0.51364,1.61,0.0256,16,0.345,"RNASE3",1.59176003468815,0.462180904926726,FALSE +"H1975","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.39029,-1.46,0.0807,10027,1,"IFNA4, TSHR, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, IL2, FASLG, TSHB, CD80, IFNA13, CTLA4, IL10, IFNA21, PRF1, TPO, IFNA8, CGA, IFNA1, IFNA5, CD86, GZMB, FAS, TG, IL5",1.09312646527793,0,FALSE +"H1975","Input","KEGG_AXON_GUIDANCE",0.30621,0.948,0.52,5502,0.851,"SEMA5B, LIMK1, PAK6, NGEF, RAC2, ABLIM3, NTN1, EPHB4, PAK2, SEMA4B, EFNA4, RASA1, RAC1, EFNA1, SEMA7A, PAK1, SEMA3A, SEMA3B, MET, GNAI2, ABLIM1, CFL2, ABLIM2, UNC5A, PLXNB3, PPP3CA, GSK3B, NFATC3, NRP1, EPHA1, MAPK1, SRGAP1, RHOA, EPHB2, SEMA6C, EPHA6, CDK5, ROCK2, ABL1, EFNB2, SEMA3C, SEMA6B, RHOD, SEMA3E, ITGB1, ROBO3, SRGAP2, GNAI1, SEMA4C, EFNA5",0.283996656365201,0.0700704399154121,FALSE +"H1975","Input","KEGG_BASAL_CELL_CARCINOMA",-0.21862,-0.823,0.715,15646,1,"WNT2B, FZD5, GLI1, WNT7A, DVL3, WNT8B, FZD7, WNT6, HHIP, WNT10A, AXIN2, WNT4, WNT11, WNT5A, FZD8, FZD1, LEF1, WNT5B, SMO",0.145693958198919,0,FALSE +"H1975","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.26325,-0.991,0.413,17864,1,"TAF13, GTF2F2, GTF2B, STON1, GTF2A2, GTF2H2",0.384049948343599,0,FALSE +"H1975","Input","KEGG_BASE_EXCISION_REPAIR",0.37222,1.16,0.239,4598,0.602,"POLD4, POLD2, NTHL1, SMUG1, APEX2, APEX1, OGG1, MBD4, PARP2, POLE3, POLE2, PCNA, PARP3, POLE4",0.621602099051862,0.220403508742175,FALSE +"H1975","Input","KEGG_BETA_ALANINE_METABOLISM",0.54922,1.69,0.0162,4373,0.269,"AOC2, ALDH9A1, SMS, AOC3, ECHS1, ALDH1B1, HADHA, SRM, EHHADH",1.79048498545737,0.570247719997592,FALSE +"H1975","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.34961,1.09,0.327,4115,0.692,"ELOVL6, HACD1, ACAA1, HADHA, ACOT4, ACOT1, SCD",0.485452247339714,0.159893905543242,FALSE +"H1975","Input","KEGG_BLADDER_CANCER",-0.26046,-0.93,0.559,17226,1,"FGFR3, EGF, E2F2, HRAS, CXCL8, MMP2, MDM2, VEGFC, KRAS, RB1",0.252588192113577,0,FALSE +"H1975","Input","KEGG_BUTANOATE_METABOLISM",0.36894,1.17,0.215,3682,0.599,"ALDH9A1, ECHS1, PDHA1, ACAT1, ALDH1B1, HADHA, L2HGDH, OXCT1, PDHB, ACSM3",0.667561540084395,0.222573177610689,FALSE +"H1975","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.2891,0.904,0.602,4395,0.865,"CD79A, CD19, VAV1, MAP2K2, RAC2, LILRB3, CARD11, RAC1, LYN, PIK3R2, IFITM1, CHUK, IKBKG, PIK3CA, PPP3CA, GSK3B, NFATC3, MAPK1, PIK3CB, VAV2, PLCG2",0.220403508742175,0.0629838925351858,FALSE +"H1975","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.27157,0.848,0.681,2913,0.888,"NOS3, P2RX6, GRIN2A, MYLK2, PTGER1, P2RX5, GNA15, CALM1, GRIN1, CACNA1B, CACNA1A, ADCY7, GNA11, PHKA1, ADORA2B, EDNRA, ADORA2A, HRH1, MYLK, GRIN2D, TBXA2R, SPHK1, PRKCA, F2R, TRPC1, ITPR1, PRKACA, SLC25A5, ATP2B1, ATP2B4",0.166852888087215,0.051587034221399,FALSE +"H1975","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.24677,-0.857,0.597,16714,1,"CACNA2D3, CACNA2D4, ATP1B1, CACNB4, UQCRFS1, CACNA1C, RYR2, CACNA1D, SLC9A1, TPM2, UQCRHL, ATP2A2, TNNC1, SLC8A1, COX7A2, ATP1A3, CYC1, COX6A1, CACNA2D1, COX6B1",0.224025668870631,0,FALSE +"H1975","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.19139,-0.689,0.891,16314,0.943,"NRXN2, CD6, ITGA9, NLGN4X, SDC2, CNTN1, CD4, ESAM, JAM2, CNTNAP2, CDH4, ITGAM, NRXN3, NCAM2, NEGR1, MPZL1, NLGN1, NCAM1, ITGA4, NFASC, NECTIN2, NRCAM, JAM3, CLDN1, ITGB8, CDH2",0.0501222959631252,0.0254883072626717,FALSE +"H1975","Input","KEGG_CELL_CYCLE",0.37701,1.18,0.221,5773,0.609,"SMC1B, YWHAH, CCNA1, ATR, DBF4, MYC, CDC25B, FZR1, CDK7, TP53, CCNB1, CUL1, PLK1, YWHAQ, CDKN1C, RBL1, BUB3, GADD45B, SFN, CDC20, ESPL1, SMC1A, MCM7, TFDP2, STAG2, BUB1, YWHAE, CCNH, TGFB2, CHEK1, GSK3B, ORC5, CDC45, PCNA, MCM2, E2F4, CDKN2B, TGFB3, MCM6, CDC27, ORC2, ABL1, CDC25C, SMAD4, PKMYT1, ANAPC2, MCM5, SMC3, CHEK2, EP300, ORC6, SMAD3, CDK4, ANAPC1, CDKN2A, SKP1, TTK, E2F1, CDC6, YWHAG",0.655607726314889,0.215382707367125,FALSE +"H1975","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.20737,-0.805,0.731,16907,1,"ADCY5, GNG5, XCL1, NFKBIA, CXCL1, SHC2, CSK, CXCL3, ELMO1, GNG2, CXCR4, PIK3CD, HRAS, CXCL8, PRKACB, CCL20, JAK2, ADCY1, PTK2, GNB1, AKT3, PLCB4, PIK3R1, KRAS, ADCY6, GNG4, NFKBIB, PLCB1, CXCL16, AKT2, GSK3A",0.13608262304214,0,FALSE +"H1975","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.20631,0.646,0.93,5841,0.976,"MAP2K2, MYC, ARAF, TP53, MECOM, CRK, SHC3, PIK3R2, CHUK, IKBKG, TGFB2, PIK3CA, BCR, STAT5B, MAPK1, CTBP2, PIK3CB, TGFB3, RUNX1, ABL1, SMAD4, BRAF, CBLC, SMAD3, AKT1, CDK4, CDKN2A, E2F1, TGFBR1",0.0315170514460649,0.0105501823333082,FALSE +"H1975","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.43941,-1.67,0.0333,16670,0.799,"PER2, CRY2, CSNK1D, CRY1",1.47755576649368,0.0974532206860086,FALSE +"H1975","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.47633,1.51,0.0573,3635,0.489,"PC, IDH3G, IDH3B, MDH2, DLD, PDHA1, SDHA, SDHC, OGDH, CS, PDHB, ACO2",1.24184537803261,0.31069114087638,FALSE +"H1975","Input","KEGG_COLORECTAL_CANCER",0.24649,0.775,0.779,5841,0.951,"RAC2, MYC, ARAF, TP53, RAC1, MLH1, PIK3R2, MSH6, APPL1, APC, TGFB2, PIK3CA, GSK3B, CYCS, MAPK1, RHOA, PIK3CB, TGFB3, SMAD4, RALGDS, BRAF, SMAD3, AKT1, AXIN1, FOS, TGFBR1",0.108462542327436,0.0218194830625861,FALSE +"H1975","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.33882,1.06,0.373,2604,0.736,"C4B, C4A, SERPINA5, PROS1, SERPINA1, CFB, F8, C3, SERPINE1, PLAU, F2R, TFPI",0.428291168191312,0.133122185662501,FALSE +"H1975","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.41449,1.3,0.131,3574,0.501,"LDHC, LDHA, SMS, DNMT1, ADI1, AHCY, LDHAL6B, GOT2, MTR, SRM",0.882728704344236,0.300162274132754,FALSE +"H1975","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.20255,0.628,0.953,3472,0.982,"CRLF2, CSF1R, IL12B, EPOR, TNFRSF18, TNFRSF11A, CLCF1, TNFRSF6B, TNFSF9, AMH, IL7R, BMP2, IL11, IL13RA1, IL1RAP, CCL26, IL24, TNFSF12, CD70, OSMR, IL4R, IL15RA, CD40, IL1R1, CX3CL1, CCL28, MET, ACVR1B, IL6R, LIFR, CSF1, KITLG, CTF1, CCR4, TGFB2",0.0209070993616736,0.00788851221305034,FALSE +"H1975","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.27408,0.866,0.645,3898,0.891,"AIM2, MAVS, ADAR, POLR3H, POLR3G, POLR3A, DDX58, POLR3GL, CHUK, IKBKG, POLR1C",0.190440285364732,0.0501222959631252,FALSE +"H1975","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.22818,-0.85,0.605,14422,1,"IGF1, CACNG1, ADRB1, ACTC1, ADCY2, ITGA1, TGFB1, TNNT2, SGCG, CACNA2D2, ADCY4, TNF, CACNG7, ITGA7, SGCD, ITGA9, CACNA2D3, ADCY5, CACNA2D4, CACNB4, CACNA1C, RYR2, LAMA2, CACNA1D, TPM2, ITGA4, ATP2A2, PRKACB, TNNC1, SLC8A1, ADCY1, DMD, CACNA2D1, ADCY6, ITGB8",0.218244625347531,0,FALSE +"H1975","Input","KEGG_DNA_REPLICATION",0.48318,1.49,0.0642,5008,0.424,"POLD4, POLD2, RPA3, RNASEH2A, RNASEH1, PRIM1, SSBP1, RFC2, MCM7, POLE3, RNASEH2C, POLE2, RPA1, PCNA, MCM2, MCM6, POLE4, MCM5",1.19246497193115,0.372634143407267,FALSE +"H1975","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.19145,-0.687,0.802,12053,0.924,"SOS2, MAP2K1, ETV6, NOTCH4, PIWIL4, PIWIL3, PIWIL2, PIWIL1, ETV7, NOTCH3, CPEB1, FMN2, KRAS",0.0958256317158365,0.0343280287798933,FALSE +"H1975","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.40864,1.26,0.173,4256,0.512,"CYP2C9, GSTT2, CYP2E1, ALDH3B1, CYP2C8, GSTZ1, GSTO2, ALDH3B2, GSTK1, MAOB, AOX1, MGST1, MGST3, MAOA, FMO4, GSTP1",0.761953896871205,0.290730039024169,FALSE +"H1975","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.42535,1.32,0.124,3217,0.514,"IMPDH2, CDA, HPRT1, UPP1, IMPDH1, UMPS, TYMP, UCK2, ITPA, TK2",0.906578314837765,0.289036881004724,FALSE +"H1975","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.20917,-0.778,0.756,15893,0.992,"CD36, ITGA7, COL11A1, COL5A3, THBS2, HSPG2, ITGA9, SDC2, VWF, LAMA5, COL4A4, COL3A1, LAMA2, LAMC3, LAMA1, SV2A, COL5A2, ITGA4, LAMA4, ITGB8, COL4A1, COL4A2, LAMB1",0.121478204498793,0.00348832784582135,FALSE +"H1975","Input","KEGG_ENDOCYTOSIS",0.24636,0.771,0.817,5364,0.95,"CSF1R, CHMP2A, RABEP1, EPN1, SMURF1, CHMP3, SH3KBP1, RAB31, LDLR, DNM2, GRK5, PIP5K1C, RAB11B, GRK3, HSPA1A, PLD2, F2R, RBSN, HSPA2, MET, STAM, SH3GL1, AP2M1, EHD2, GRK2, IQSEC1, PDCD6IP, ITCH, AGAP1, HSPA1B, CHMP4C, AP2B1, HSPA8, EPN3, MVB12A, ARF6, ARFGAP3, PSD4, CLTCL1, VPS45, ACAP1, ARRB1, CLTC, RNF41, EGFR, EEA1, ADRB2, STAM2, CHMP2B, CBLC, RAB11FIP2, SNF8, RAB11FIP1, ARFGAP1",0.0877779434675845,0.0222763947111523,FALSE +"H1975","Input","KEGG_ENDOMETRIAL_CANCER",0.24916,0.777,0.786,4970,0.956,"MAP2K2, MYC, ARAF, PTEN, TP53, MLH1, ELK1, PIK3R2, APC, CDH1, PIK3CA, GSK3B, FOXO3, MAPK1, PIK3CB, EGFR, PDPK1, BRAF",0.104577453960592,0.0195421077238999,FALSE +"H1975","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.23816,0.76,0.814,4626,0.961,"ATP6V0D2, NOD1, ATP6V0D1, RAC1, MAP2K4, LYN, PAK1, ATP6V1D, MET, ATP6V1F, ATP6V1E2, MAPK12, CHUK, IKBKG, MAPK13, TCIRG1, F11R, ATP6V0E2, PLCG2, EGFR",0.0893755951107988,0.0172766123314547,FALSE +"H1975","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.24386,0.755,0.818,5113,0.961,"RPS6KB2, MAP2K2, PAK6, MYC, ARAF, PAK2, MAP2K4, CRK, ABL2, PRKCA, ELK1, PAK1, SHC3, MAP2K7, PIK3R2, PIK3CA, GSK3B, STAT5B, MAPK1, PIK3CB, NRG1, PLCG2, EGFR, ABL1, BRAF, CBLC, CAMK2D",0.087246696328677,0.0172766123314547,FALSE +"H1975","Input","KEGG_ETHER_LIPID_METABOLISM",0.29926,0.931,0.543,4032,0.865,"LPCAT1, PLA2G2C, PAFAH1B1, PLPP2, PLD2, AGPS, PLA2G12A, LPCAT2",0.265200170411153,0.0629838925351858,FALSE +"H1975","Input","KEGG_FATTY_ACID_METABOLISM",0.41741,1.3,0.137,4656,0.501,"GCDH, ALDH9A1, ACSL4, ACAA1, ECHS1, ACSL5, ACAT1, ALDH1B1, HADHA, ACADVL, CPT1C, ACADSB, EHHADH, ACAA2",0.863279432843593,0.300162274132754,FALSE +"H1975","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.2102,-0.794,0.771,16759,0.983,"MAPK11, INPP5D, PLA2G10, IL13, PLCG1, PLA2G4A, MAPK10, PIK3CD, HRAS, PLA2G4B, AKT3, PIK3R1, GAB2, KRAS, MAP2K6, AKT2",0.112945621949043,0.00744648216786438,FALSE +"H1975","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.27975,0.862,0.663,4395,0.883,"RPS6KB2, VAV1, LIMK1, RAC2, PLA2G4D, ARPC1A, DNM2, PIP5K1C, RAC1, CRK, LYN, ARPC1B, MYO10, SPHK1, PRKCA, PAK1, PLPP2, PLD2, PIK3R2, CFL2, PIK3CA, WASL, ARF6, MAPK1, PRKCD, PIK3CB, VAV2, PLCG2",0.178486471595227,0.0540392964224314,FALSE +"H1975","Input","KEGG_FOCAL_ADHESION",0.22691,0.696,0.883,5199,0.956,"PPP1CA, VAV1, MYLK2, THBS3, PAK6, RAC2, COL5A1, PTEN, ARHGAP5, ITGA5, ITGA2B, PAK2, LAMB3, PIP5K1C, ITGB3, ACTN1, TNC, MYLK, RAC1, ACTB, CRK, CAV2, PRKCA, FLNA, ELK1, ZYX, PAK1, SHC3, CAV1, DIAPH1, MYL9, MET, VTN, MYL7, PIK3R2, XIAP, LAMA3, PIK3CA, COL1A1, PPP1CB, CAPN2, GSK3B, MAPK1, BCAR1, ITGA3, RHOA, PIK3CB, FN1, VAV2, COL1A2, VCL, EGFR, ROCK2, LAMB2, PDPK1, FLNB, ITGA2, LAMC2, BRAF, DOCK1, LAMC1, ITGB1",0.0540392964224314,0.0195421077238999,FALSE +"H1975","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.3703,-1.36,0.155,12122,1,"ALPI, ALPL, ALPG, QDPR, ALPP, PTS, GGH, GCH1",0.809668301829709,0,FALSE +"H1975","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.44997,1.4,0.0899,7631,0.489,"ALDOA, FBP1, PFKFB4, ALDOC, GMPPA, AKR1B1, HK2, GMPPB, PFKP, HK1, PFKFB3, PMM1, SORD, MTMR2, PFKFB1, MPI, PFKFB2, PFKL, PFKM, PMM2, FBP2, GMDS, MTMR1",1.04624030826677,0.31069114087638,FALSE +"H1975","Input","KEGG_GALACTOSE_METABOLISM",0.4783,1.48,0.0759,6884,0.423,"GCK, AKR1B1, HK2, GALK1, PGM2, PFKP, GLA, HK1, UGP2, GAA, PGM1, B4GALT1, GALE, PFKL",1.11975822410452,0.373659632624958,FALSE +"H1975","Input","KEGG_GAP_JUNCTION",-0.22836,-0.822,0.711,15831,1,"TUBB4A, GNAI3, DRD2, GUCY1B1, HTR2C, PDGFD, ADCY5, PDGFRA, GUCY1A2, PRKG1, PRKG2, GUCY1A1, TUBB1, EGF, CSNK1D, HRAS, PRKACB, MAP2K5, ADCY1, PLCB4, KRAS, ADCY6, LPAR1, PLCB1",0.148130399270234,0,FALSE +"H1975","Input","KEGG_GLIOMA",-0.26745,-0.987,0.382,17036,1,"PDGFRA, CALML6, CAMK2B, SHC2, EGF, PLCG1, E2F2, PIK3CD, HRAS, AKT3, PIK3R1, MDM2, KRAS, RB1, AKT2",0.417936637088291,0,FALSE +"H1975","Input","KEGG_GLUTATHIONE_METABOLISM",0.41165,1.28,0.144,4822,0.494,"GSTT2, GPX4, ANPEP, GSTZ1, GSTO2, SMS, GSTK1, GPX3, GPX1, RRM2, MGST1, SRM, MGST3, GSTP1, G6PD, GGCT, ODC1, GGT7, GSTM2, GSS",0.84163750790475,0.306273051076353,FALSE +"H1975","Input","KEGG_GLYCEROLIPID_METABOLISM",0.40366,1.25,0.169,4681,0.523,"GPAT2, DGKI, LIPG, AWAT2, ALDH9A1, DGKD, AKR1B1, AGK, DGKG, ALDH1B1, PLPP2, GPAT3, MGLL, MBOAT2, GK, AGPAT4, GLA, DGKE, GPAM",0.772113295386326,0.281498311132726,FALSE +"H1975","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33238,1.02,0.41,4681,0.791,"GPAT2, DGKI, LPCAT1, PLA2G2C, MBOAT7, CDS2, PEMT, CRLS1, DGKD, DGKG, CHKA, PLPP2, PLD2, GPAT3, CHAT, PISD, CDIPT, MBOAT2, PLA2G12A, LPCAT2, AGPAT4, PCYT1A, DGKE, GPAM",0.387216143280265,0.101823516502323,FALSE +"H1975","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.47415,1.49,0.0546,3268,0.424,"SARDH, AOC2, SRR, AOC3, DLD, SHMT1, MAOB, GCAT, PSPH, SHMT2",1.26280735729526,0.372634143407267,FALSE +"H1975","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.50151,1.57,0.0412,2784,0.396,"GCK, LDHC, ALDH3B1, ALDOA, PGK1, LDHA, FBP1, ALDH9A1, ALDH3B2, ALDOC, DLD, PDHA1, GALM, PGAM1, LDHAL6B, ALDH1B1, HK2",1.38510278396687,0.402304814074488,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.36869,1.16,0.215,5040,0.602,"CHST15, CHPF2, CHPF, CHST3, DSE, CHST11, CHST12, UST",0.667561540084395,0.220403508742175,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.19621,-0.743,0.816,12537,1,"HS3ST1, HS2ST1, NDST4, HS3ST2, HS6ST1, NDST2, EXTL1, HS3ST5, HS6ST3, NDST3, B3GAT1, B3GAT2, XYLT1",0.0883098412461389,0,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.48123,1.49,0.0552,1059,0.424,"CHST4, CHST6, FUT8, B3GNT7",1.2580609222708,0.372634143407267,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.41649,1.29,0.139,4328,0.498,"IDS, HYAL2, HYAL3, GALNS, HS3ST3B1, HYAL1, NAGLU, HEXB",0.856985199745905,0.302770657240282,FALSE +"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.24119,-0.904,0.568,14944,1,"B3GALT4, ST8SIA5, ST6GALNAC5, ST6GALNAC3, HEXA, ST3GAL5",0.245651664288981,0,FALSE +"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.43308,1.36,0.103,6501,0.503,"FUT2, B3GALNT1, ST3GAL2, GLA, HEXB, A4GALT, NAGA, ST8SIA1, GBGT1, B3GALT5",0.987162775294828,0.298432014944073,FALSE +"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.23892,-0.903,0.569,15377,1,"ST3GAL4, ST3GAL3, B3GALT2, FUT9, B3GALT1, B3GNT2, B4GAT1, B4GALT4, ST3GAL6",0.244887733604929,0,FALSE +"H1975","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.27147,0.849,0.679,6205,0.894,"PIGQ, PIGL, PIGW, DPM2, PIGX, PIGH, PIGA, PIGG, PIGM, PIGB, PIGV, PIGN, PGAP1",0.168130225719498,0.0486624812040823,FALSE +"H1975","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.35487,1.11,0.286,4253,0.682,"MTHFD1, MDH2, CS, ACO2, HYI",0.543633966870957,0.166215625343521,FALSE +"H1975","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.22997,-0.833,0.644,16759,1,"MAPK11, ADCY5, PLA2G10, CACNA1C, CALML6, CAMK2B, CACNA1D, PLA2G4A, MAPK10, HRAS, PRKACB, PLA2G4B, MMP2, GNRH1, ADCY1, PLCB4, KRAS, ADCY6, ATF4, PLCB1, MAP2K6",0.191114132640188,0,FALSE +"H1975","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.26642,-1.01,0.397,14812,1,"KLRD1, CD86, GZMB, FAS, TNF, IL1A, IL1B",0.401209493236885,0,FALSE +"H1975","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.23504,-0.885,0.616,17337,1,"HHIP, WNT10A, WNT4, WNT11, GAS1, CSNK1D, WNT5A, BMP6, BMP7, PRKACB, WNT5B, SMO",0.210419287835575,0,FALSE +"H1975","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.31328,0.964,0.488,3553,0.85,"CSF1R, CD19, EPOR, ANPEP, IL7R, IL11, ITGA5, ITGA2B, ITGB3, IL4R, IL1R1, IL6R, CSF1, KITLG, CD44",0.311580177997289,0.0705810742857073,FALSE +"H1975","Input","KEGG_HISTIDINE_METABOLISM",0.54462,1.71,0.0142,3072,0.334,"FTCD, ALDH3B1, ALDH9A1, ALDH3B2, HEMK1, MAOB, HNMT, METTL6, ALDH1B1, METTL2B",1.84771165561694,0.476253533188435,FALSE +"H1975","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.53981,1.7,0.0212,3919,0.281,"POLD4, POLD2, NBN, RPA3, RAD51B, XRCC2, XRCC3, SSBP1, RAD51D, TOP3B, MRE11, TOP3A, RPA1",1.67366413907125,0.55129368009492,FALSE +"H1975","Input","KEGG_HUNTINGTONS_DISEASE",0.37717,1.17,0.228,3032,0.599,"DNAH2, NDUFV1, CREB3L3, COX8C, DNAH3, UQCR11, NDUFS8, CREB3L1, UQCR10, HIP1, TBPL2, NDUFA7, ATP5F1B, GRIN1, NDUFB7, COX6B2, TP53, RCOR1, POLR2E, DNAH1, PPARG, DNAL1, POLR2J, IFT57, NDUFA6, SDHA, POLR2F, NDUFS2, CASP8, NDUFB2, NDUFS7, TGM2, NDUFA3, SDHC, UQCRC1, GPX1, ITPR1, ATP5F1D, SLC25A5, NDUFB6, AP2M1, NDUFA8, TFAM, POLR2H",0.642065152999546,0.222573177610689,FALSE +"H1975","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.22257,-0.776,0.721,15780,0.968,"TNF, CACNG7, ITGA7, SGCD, ITGA9, CACNA2D3, CACNA2D4, CACNB4, CACNA1C, RYR2, LAMA2, CACNA1D, TPM2, ITGA4, ATP2A2, PRKAG1, TNNC1, SLC8A1, DMD, CACNA2D1, ITGB8, PRKAA2, PRKAB1",0.142064735280571,0.0141246426916063,FALSE +"H1975","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.23056,0.711,0.872,5131,0.961,"PTEN, PIP5K1C, IMPA2, IPMK, PIP4K2C, INPP5J, PIP4K2A, PI4KB, PIK3CA, CDIPT, INPP5K, PIK3C2A, PIK3CB, PLCG2, PIK3C3, PLCE1, SYNJ2",0.0594835150674328,0.0172766123314547,FALSE +"H1975","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.3059,0.962,0.489,4088,0.845,"GCK, PPP1CA, RPS6KB2, MAP2K2, PRKAR1B, CALM1, FBP1, ARAF, PYGL, PHKA1, CRK, INSR, ELK1, PRKAG2, SHC3, PPP1R3B, PRKAB2, PRKAA1, HK2, PPP1R3C, PRKACA, TRIP10, PIK3R2, SORBS1, PYGB, IRS1, PRKAR2A, MKNK2, PIK3CA, PHKB, PPP1CB, GSK3B, TSC1, PTPN1, INPP5K, MAPK1, RHEB, PIK3CB",0.31069114087638,0.0731432910503077,FALSE +"H1975","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.20136,-0.742,0.827,14917,0.983,"TGFB1, CD86, ICOSLG, CCL27, IL5, CXCL12, TNFSF13B, TNFRSF13C, CXCR4, ITGA4",0.0824944904474534,0.00744648216786438,FALSE +"H1975","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.21942,0.682,0.91,4091,0.965,"CRLF2, IL12B, EPOR, TYK2, CLCF1, IL7R, MYC, IL11, IL13RA1, IL24, OSMR, IL4R, IL15RA, PIAS4, STAM, PIAS2, PIAS3, PIK3R2, IL6R, LIFR, JAK3, STAT6, CTF1, PIK3CA, STAT5B, IRF9, PIK3CB, IFNGR1",0.0409586076789064,0.0154726866562074,FALSE +"H1975","Input","KEGG_LEISHMANIA_INFECTION",0.22892,0.719,0.875,4133,0.966,"IL12B, C3, IRAK1, ELK1, ITGB2, IRAK4, MAPK12, TGFB2, TAB1, CYBA, MYD88, MAPK1, MAPK13, IFNGR1, TGFB3",0.0579919469776868,0.0150228735845067,FALSE +"H1975","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.19732,0.605,0.951,5361,0.976,"VAV1, RAC2, ARHGAP5, CLDN9, ACTN1, RAC1, ACTB, CLDN4, PRKCA, ITGB2, MYL9, MSN, MYL7, GNAI2, PIK3R2, ICAM1, MAPK12, CLDN23, CLDN7, PIK3CA, CYBA, MAPK13, BCAR1, RHOA, PIK3CB, F11R, VAV2, PLCG2, SIPA1, VCL, ROCK2, PTK2B, CLDN15, ITGB1, GNAI1, NCF2, CLDN22",0.0218194830625861,0.0105501823333082,FALSE +"H1975","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.6488,2.02,0.00356,4373,0.436,"ALDH9A1, NAA80, ECHS1, ALDH1B1, HADHA, EHHADH",2.44855000202712,0.360513510731414,FALSE +"H1975","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.46749,1.45,0.0795,606,0.462,"CYP2C9, CYP2E1, CYP2C8, PLA2G2C",1.09963287134353,0.335358024443874,FALSE +"H1975","Input","KEGG_LONG_TERM_DEPRESSION",0.23549,0.722,0.837,2875,0.977,"PPP2R1A, MAP2K2, PLA2G2C, GNA12, ARAF, CACNA1A, GNA11, LYN, PRKCA, ITPR1, GNAI2",0.07727454200674,0.0101054362812269,FALSE +"H1975","Input","KEGG_LONG_TERM_POTENTIATION",0.25539,0.802,0.764,2802,0.954,"PPP1CA, GRIN2A, MAP2K2, CALM1, RPS6KA3, GRIN1, ARAF, GRIN2D, RPS6KA2, PRKCA, ITPR1, PRKACA",0.11690664142431,0.0204516252959049,FALSE +"H1975","Input","KEGG_LYSINE_DEGRADATION",0.29949,0.934,0.541,5620,0.867,"GCDH, ALDH9A1, AADAT, SUV39H1, ECHS1, ACAT1, PLOD2, SETMAR, ALDH1B1, HADHA, OGDH, KMT5C, EHHADH, KMT5B, SETD2, PLOD1, ASH1L, PLOD3, DLST",0.266802734893431,0.0619809025237897,FALSE +"H1975","Input","KEGG_LYSOSOME",0.42113,1.32,0.12,4887,0.514,"AP3S1, ACP5, NPC1, ATP6V0D2, LIPA, NAGPA, AP1B1, CTNS, LGMN, GALC, ATP6V0D1, CTSA, ABCB9, AP1S1, IDS, CD68, DNASE2, AP3D1, PSAP, CTSG, SUMF1, CTSF, LAMP2, CTSD, TPP1, GALNS, CTSL, AP1M1, AP1S3, GBA, AP3B1, NPC2, AP4S1, NAPSA, HYAL1, MAN2B1, NAGLU, AGA, CTSS, CLTCL1, GLA, TCIRG1, CTSC, HEXB, CTSB, CLTC, AP1G1, NAGA, NEU1, CTSV, MCOLN1",0.920818753952375,0.289036881004724,FALSE +"H1975","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.22854,0.718,0.863,4176,0.96,"ECSIT, MAP2K2, CACNG8, PLA2G2C, RAC2, MAPKAPK3, MAX, MYC, RPS6KA3, CDC25B, GNA12, CACNA1B, DUSP9, PPM1A, CACNA1A, PAK2, TP53, MECOM, RASA1, HSPB1, RAC1, MAP2K4, CRK, HSPA1A, MAP3K20, RPS6KA2, PRKCA, FLNA, ELK1, PAK1, IL1R1, GADD45B, MAP3K3, MAP2K7, HSPA2, PRKACA, RRAS2, DUSP10, MAP4K4, FGF1, MAPK12, MRAS, CHUK, MAPK8IP2, DUSP2, IKBKG, TGFB2, MKNK2, HSPA1B, HSPA8, PPP3CA, RPS6KA4, TAB1, FGF13, MAPK1, MAPK13, PLA2G12A, DUSP3, TGFB3, MAP3K6",0.0639892042847904,0.0177287669604316,FALSE +"H1975","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.38632,1.21,0.196,11,0.57,"GCK",0.707743928643524,0.244125144327509,FALSE +"H1975","Input","KEGG_MELANOGENESIS",-0.18683,-0.718,0.873,15583,0.974,"NRAS, WNT2B, EDNRB, FZD5, GNAI3, WNT7A, TYRP1, DVL3, WNT8B, FZD7, KIT, ADCY5, WNT6, CALML6, CAMK2B, WNT10A, WNT4, WNT11, WNT5A, HRAS, PRKACB, FZD8, FZD1, ADCY1, LEF1, PLCB4, WNT5B, KRAS, ADCY6, PLCB1",0.0589857562944303,0.0114410431213845,FALSE +"H1975","Input","KEGG_MELANOMA",-0.27622,-1.04,0.362,14247,1,"PIK3R3, FGF19, FGF20, IGF1, CDKN1A, HGF, PIK3CG, FGF18, FGF9, FGF7, FGF21, NRAS, FGF14, CDK6, E2F3, PDGFD, PDGFRA, FGF17, FGF5, EGF, E2F2, PIK3CD, HRAS, FGF12, AKT3, PIK3R1, MDM2, KRAS, FGF2, RB1, AKT2",0.441291429466834,0,FALSE +"H1975","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.41512,1.29,0.135,1829,0.498,"CYP2C9, GSTT2, CYP2E1, ALDH3B1, CYP1B1, CYP2C8, GSTZ1, GSTO2, ALDH3B2, GSTK1",0.869666231504994,0.302770657240282,FALSE +"H1975","Input","KEGG_MISMATCH_REPAIR",0.5466,1.7,0.0243,4075,0.281,"POLD4, POLD2, RPA3, PMS2, MLH1, SSBP1, RFC2, MSH6, EXO1, RPA1, PCNA",1.61439372640169,0.55129368009492,FALSE +"H1975","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.25271,0.786,0.76,4088,0.957,"RPS6KB2, RPS6KA3, CAB39, HIF1A, MLST8, RPS6KA2, PRKAA1, RICTOR, PIK3R2, PIK3CA, STK11, TSC1, MAPK1, RHEB, PIK3CB",0.119186407719209,0.0190880622231565,FALSE +"H1975","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.21448,0.663,0.921,4488,0.976,"VAV1, MAP2K2, RAC2, ARAF, KLRC1, RAC1, ICAM2, PRKCA, PAK1, ITGB2, SHC3, RAET1E, PIK3R2, ULBP3, RAET1L, ICAM1, PIK3CA, PPP3CA, NFATC3, SH3BP2, MAPK1, KIR2DL1, PIK3CB, IFNGR1, VAV2, PLCG2, RAET1G",0.0357403698031511,0.0105501823333082,FALSE +"H1975","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.19263,0.599,0.969,2791,0.972,"GLP2R, P2RX6, GRIN2A, PTGER1, P2RX5, GIPR, GRIN1, CALCR, GABRD, TRPV1, P2RY6, F2RL1, FPR1, P2RY14, ADORA2B, EDNRA, ADORA2A, HRH1, GRIN2D, GABRB3, GRM6, NR3C1, CTSG, TBXA2R, P2RY2, MCHR1, F2R, LPAR2, TSPO",0.0136762229492347,0.0123337350737254,FALSE +"H1975","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.25301,-0.925,0.526,17113,1,"FRS2, NFKBIA, IRAK3, CALML6, NTF3, TRAF6, CAMK2B, SHC2, CSK, PLCG1, NGFR, MAPK10, BCL2, PIK3CD, HRAS, TP73, MAP2K5, CAMK4, AKT3, PIK3R1, KRAS, ATF4, NFKBIB, NFKBIE, SORT1, AKT2, BEX3",0.279014255846261,0,FALSE +"H1975","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.43901,1.37,0.0979,4413,0.498,"NAMPT, NNMT, NT5C2, PNP, NT5M, AOX1, NMRK1, BST1, NT5E, NMNAT1",1.00921730819686,0.302770657240282,FALSE +"H1975","Input","KEGG_NITROGEN_METABOLISM",0.31586,0.989,0.45,2132,0.813,"CA9, GLS, CA12, GLUD1",0.346787486224656,0.0899094544059319,FALSE +"H1975","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.23487,-0.869,0.645,15780,1,"TNF, BIRC2, TNFAIP3, SUGT1, NOD2, TAB2, IKBKB, MAPK11, MAP3K7, IL1B, NFKBIA, TRAF6, NLRP3, CXCL1, NLRC4, MAPK10, CXCL8, BIRC3, HSP90B1, NFKBIB",0.190440285364732,0,FALSE +"H1975","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.34581,1.07,0.335,3926,0.731,"XRCC4, XRCC6, MRE11, NHEJ1",0.474955192963155,0.13608262304214,FALSE +"H1975","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.33082,-1.22,0.202,17577,1,"EGF, PLCG1, E2F2, PIK3CD, HRAS, RARB, FHIT, AKT3, CASP9, PIK3R1, KRAS, RB1, AKT2",0.694648630553376,0,FALSE +"H1975","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.19857,0.624,0.952,6732,0.978,"SNW1, DTX3L, APH1A, DVL2, LFNG, MFNG, PSEN1, NOTCH1, CTBP2, JAG1, PSEN2, DVL1, EP300, NUMB, NOTCH2, RBPJ, DTX3, NCSTN, HES1, KAT2A, MAML1",0.0213630516155257,0.00966114521239857,FALSE +"H1975","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.3761,1.17,0.228,4644,0.599,"ERCC6, POLD4, RAD23A, CETN2, CUL4B, POLD2, RPA3, CDK7, RFC2, POLE3, CCNH, POLE2, RPA1, MNAT1, PCNA, RAD23B, POLE4, ERCC8",0.642065152999546,0.222573177610689,FALSE +"H1975","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.2515,0.799,0.765,5039,0.943,"FUT8, ALG10, MGAT5B, RFT1, MGAT2, MAN1B1, ALG1, ALG10B, DPM2, STT3A, MGAT4B, DAD1, ST6GAL1, ALG2, TUSC3, ALG12",0.116338564846382,0.0254883072626717,FALSE +"H1975","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.23366,-0.855,0.608,9443,1,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, CAMK2A, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, CLCA1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR2AE1, OR5AK2, GUCA1A, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR2A7, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, PDC, OR2T4, OR2T6, OR1L6, OR13C4, ADCY3, OR2T12, OR6V1, CNGA3, OR2B3, OR4A47, OR52B4, CAMK2G, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, OR2A1, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR8B12, OR9A4, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, CALM3, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR1B1, OR2L3, OR8D1, OR51E2, OR11H6, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5B21, OR13A1, OR5M11, OR13G1, OR2L13, OR5K1, OR1M1, OR51B2, OR52D1, OR51I1, OR1J1, OR5P3, OR52N2, OR8S1, OR2AT4, OR9A2, OR51Q1, OR13D1, CALM2, OR8D2, OR2T33, OR1J2, OR2A5, OR52H1, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, CALML5, OR4D1, OR8G1, OR4F15, OR52B6, CALML3, OR2A25, OR2D3, OR1Q1, OR8A1, OR10A6, OR2A2, OR8G5, OR11H4, OR10A4, OR51B4, CLCA2, OR2D2, OR2AG1, OR10A3, OR10A2, OR2A14, OR4F17, OR2W3, OR6A2, OR56B4, OR1L8, OR2L2, PDE1C, CALML6, PRKG1, CAMK2B, GNAL, PRKG2, OR2AG2, PRKACB",0.216096420727265,0,FALSE +"H1975","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.54479,1.74,0.0115,3558,0.327,"FTCD, MTHFD1, SHMT1, SHMT2, MTR",1.93930215964639,0.485452247339714,FALSE +"H1975","Input","KEGG_OOCYTE_MEIOSIS",0.3253,1,0.44,5253,0.814,"SMC1B, PPP2R1A, PPP1CA, PPP2R5E, YWHAH, CALM1, RPS6KA3, ADCY7, CCNB1, CUL1, PLK1, YWHAQ, PPP2R5C, RPS6KA2, CDC20, ITPR1, ESPL1, PRKACA, SMC1A, MAPK12, BUB1, YWHAE, PPP1CB, PPP3CA, SPDYA, MAPK1, SLK, AURKA, CDC27, ITPR3, CDC25C, PKMYT1, ANAPC2, SMC3, CAMK2D, BTRC",0.356547323513813,0.0893755951107988,FALSE +"H1975","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.29778,0.925,0.554,4918,0.852,"GBA, MAN2B1, AGA, HEXB, NEU1, FUCA2, NEU3",0.25649023527157,0.0695604052332999,FALSE +"H1975","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.34869,1.09,0.309,2987,0.692,"NDUFV1, COX8C, ATP6V0D2, UQCR11, NDUFS8, UQCR10, NDUFA7, ATP5F1B, LHPP, NDUFB7, COX6B2, ATP6V0D1, COX10, NDUFA11, NDUFA6, SDHA, NDUFS2, NDUFB2, NDUFS7, NDUFA3, COX15, SDHC, UQCRC1, ATP6V1D, ATP5F1D, ATP6V1F, NDUFB6, NDUFA8, ATP6V1E2",0.510041520575165,0.159893905543242,FALSE +"H1975","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.55449,1.75,0.0126,3554,0.433,"GALNT15, GALNT9, GCNT1, GALNT6, GALNT10, GALNT12, GALNT18, GALNT2, C1GALT1, GALNT11, C1GALT1C1, B4GALT5, GALNT7, ST3GAL2",1.89962945488244,0.363512103646635,FALSE +"H1975","Input","KEGG_P53_SIGNALING_PATHWAY",-0.23845,-0.889,0.558,16247,1,"MDM4, CDK6, CCNG1, RCHY1, APAF1, GADD45G, SESN3, CCND2, COP1, BID, GADD45A, ZMAT3, PIDD1, SESN2, BBC3, TP73, CASP9, CD82, SESN1, MDM2",0.253365801062421,0,FALSE +"H1975","Input","KEGG_PANCREATIC_CANCER",-0.2403,-0.898,0.485,15778,1,"RAD51, VEGFD, CDC42, RAC3, BRCA2, CDK6, E2F3, IKBKB, EGF, E2F2, MAPK10, PIK3CD, ARHGEF6, AKT3, CASP9, PIK3R1, VEGFC, KRAS, RB1, AKT2",0.314258261397736,0,FALSE +"H1975","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.33383,-1.25,0.163,15433,1,"PPCDC, PPCS, VNN2, VNN1, PANK4, PANK3",0.787812395596042,0,FALSE +"H1975","Input","KEGG_PARKINSONS_DISEASE",0.2865,0.904,0.597,2969,0.865,"NDUFV1, COX8C, UQCR11, NDUFS8, UQCR10, NDUFA7, ATP5F1B, NDUFB7, COX6B2, PINK1, UBA7, NDUFA6, SDHA, NDUFS2, NDUFB2, NDUFS7, NDUFA3, SDHC, UQCRC1, ATP5F1D, SLC25A5, NDUFB6, UBE2L3, NDUFA8",0.224025668870631,0.0629838925351858,FALSE +"H1975","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.38604,1.19,0.22,5708,0.597,"TLR5, TUBB3, ARPC1A, LY96, YWHAQ, ACTB, ARPC1B, TUBA4A, PRKCA, TUBB4B, TUBA1B, CDH1, WASL, TUBA1A, TUBA1C, RHOA, NCL, KRT18, ROCK2, ABL1, TUBB6, ITGB1, ARPC5L, ARPC4, CTTN, ACTG1",0.657577319177794,0.224025668870631,FALSE +"H1975","Input","KEGG_PATHWAYS_IN_CANCER",0.19395,0.605,0.96,5225,0.976,"WNT9A, CSF1R, MAP2K2, FZD9, CCNA1, RAC2, EGLN3, MAX, MYC, BMP2, HSP90AA1, RALB, ARAF, PTEN, ITGA2B, LAMB3, TP53, MECOM, PPARD, DAPK3, FZD2, HIF1A, PPARG, TRAF3, EGLN1, RAC1, MLH1, CRK, FADD, NCOA4, RALA, DVL2, CASP8, PRKCA, PIAS4, MET, PIAS2, PIAS3, PIK3R2, TPM3, WNT7B, XIAP, LAMA3, MSH6, MITF, FGF1, APPL1, KITLG, CHUK, IKBKG, CKS1B, APC, TGFB2, CDH1, PIK3CA, EPAS1, RARA, GSK3B, BCR, STAT5B, RXRA, PTCH1, FGF13, CYCS, MAPK1, CTBP2, ITGA3, RHOA, PIK3CB, CDKN2B, TGFB3, FN1, DAPK1, GSTP1, FZD4, ETS1, PLCG2, BMP4, EGFR, RALBP1, RUNX1, ABL1, LAMB2, FH, SMAD4, ITGA2, RALGDS, LAMC2, BRAF, DVL1, CBLC, LAMC1, GLI3, ITGB1, EP300",0.0177287669604316,0.0105501823333082,FALSE +"H1975","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.39142,1.22,0.199,2379,0.569,"RPEL1, XYLB, AKR1B1, DHDH",0.701146923590293,0.244887733604929,FALSE +"H1975","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.48807,1.49,0.044,1867,0.424,"ALDOA, PRPS2, FBP1, RBKS, PGLS, RPEL1, ALDOC, PRPS1",1.35654732351381,0.372634143407267,FALSE +"H1975","Input","KEGG_PEROXISOME",0.25755,0.811,0.75,4950,0.946,"ACOX2, HACL1, ACSL4, PEX11G, PMVK, PEX19, DHRS4, ACAA1, PEX26, GSTK1, ACSL5, PEX11B, PXMP4, PAOX, DECR2, SLC25A17, CAT, PEX3, AGPS, AMACR, FAR1, EHHADH, CROT, CRAT, EPHX2, PEX2",0.1249387366083,0.0241088635982073,FALSE +"H1975","Input","KEGG_PHENYLALANINE_METABOLISM",0.58904,1.84,0.0116,2497,0.654,"ALDH3B1, AOC2, NAA80, ALDH3B2, AOC3, MIF, MAOB, GOT2",1.93554201077308,0.184422251675733,FALSE +"H1975","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.2887,0.9,0.584,5637,0.849,"DGKI, CALM1, CDS2, PTEN, PIP5K1C, DGKD, IMPA2, DGKG, PRKCA, PIP4K2C, INPP5J, PIP4K2A, ITPR1, PIK3R2, PI4KB, PIK3CA, CDIPT, INPP5K, PIK3C2A, PIK3CB, PLCG2, DGKE, PIK3C3, ITPR3, PLCE1, SYNJ2, DGKA, DGKZ, PI4KA",0.233587152887601,0.0710923097560473,FALSE +"H1975","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.44685,1.39,0.0942,5437,0.474,"HMOX1, COX10, HMOX2, UROS, COX15, EARS2, CPOX, ALAD, HCCS, PPOX, HMBS, BLVRA, FTH1, UROD",1.02594909720712,0.324221658325915,FALSE +"H1975","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.30184,0.942,0.524,4836,0.856,"ACOX2, PLTP, ACSL4, SLC27A5, SLC27A4, ANGPTL4, PPARD, ACAA1, PPARG, ACSL5, FABP5, SORBS1, CPT1C, RXRA, NR1H3, GK, SCD, EHHADH, CYP27A1, PDPK1",0.280668713016273,0.0675262353228468,FALSE +"H1975","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45483,1.42,0.0761,995,0.508,"ACOX2, HSD3B7, SLC27A5",1.11861534322943,0.294136287716081,FALSE +"H1975","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.386,1.22,0.201,5218,0.569,"CD79A, CD19, IL7R, CIITA, CD40, JAK3, IKBKG, ADA, TAP2, RFXANK, RFX5, LCK",0.696803942579511,0.244887733604929,FALSE +"H1975","Input","KEGG_PRION_DISEASES",0.23302,0.728,0.831,3888,0.977,"MAP2K2, HSPA1A, ELK1, PRKACA, NOTCH1, PRNP, MAPK1",0.080398976215889,0.0101054362812269,FALSE +"H1975","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.21291,-0.794,0.738,17438,0.983,"CDC16, CPEB1, MAPK10, PIK3CD, PRKACB, ADCY1, ANAPC7, AKT3, ANAPC13, PDE3B, PIK3R1, ANAPC10, KRAS, ADCY6, AKT2",0.131943638176958,0.00744648216786438,FALSE +"H1975","Input","KEGG_PROPANOATE_METABOLISM",0.41945,1.32,0.123,4878,0.514,"LDHC, LDHA, ALDH9A1, ECHS1, ACAT1, LDHAL6B, ALDH1B1, HADHA, PCCB, EHHADH, ACACA, SUCLG1",0.910094888560602,0.289036881004724,FALSE +"H1975","Input","KEGG_PROSTATE_CANCER",-0.281,-1.08,0.277,16569,1,"E2F3, IKBKB, PDGFD, PDGFRA, NFKBIA, AR, FOXO1, EGF, E2F2, BCL2, PIK3CD, HRAS, FGFR2, AKT3, CASP9, LEF1, PIK3R1, MDM2, KRAS, HSP90B1, ATF4, RB1, AKT2",0.557520230935551,0,FALSE +"H1975","Input","KEGG_PROTEASOME",0.40843,1.27,0.157,5843,0.503,"PSMC1, PSMF1, PSMA3, PSMC2, PSMB9, PSMD11, PSMD4, PSMD2, PSMB6, PSMA2, PSMB4, PSMD7, PSMB8, PSMD6, PSMD12, PSMB7, PSMD1, PSME1, PSMC5, SEM1, PSMB5, PSME2, PSME3, PSME4",0.804100347590766,0.298432014944073,FALSE +"H1975","Input","KEGG_PROTEIN_EXPORT",-0.44499,-1.69,0.0282,15662,1,"SPCS3, SEC62, SEC11A, IMMP1L, SEC63, SRP14, SEC11C, IMMP2L, SPCS2",1.54975089168064,0,FALSE +"H1975","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.23675,-0.909,0.474,14779,1,"ATP1B2, MDH1, ATP1A1, FXYD2, SLC38A3, GLS2, CA2, ATP1B1, ATP1A3, PCK2",0.324221658325915,0,FALSE +"H1975","Input","KEGG_PURINE_METABOLISM",0.32959,1.03,0.398,5239,0.785,"POLD4, IMPDH2, NME5, GUCY2D, PRPS2, HPRT1, PDE4A, POLD2, APRT, IMPDH1, ADCY7, AK4, AK7, POLR2E, PDE2A, NME7, PAPSS2, PFAS, ADK, PRPS1, POLR3H, POLR2J, AK1, NT5C2, PNP, POLR2F, GUK1, POLR3G, PRIM1, NT5M, POLR3A, NME2, PDE5A, ITPA, POLR2H, POLR3GL, POLE3, RRM2, POLE2, ENTPD5, ADSL, ADA, POLR1C, NT5E, NME3, NME6, POLR1E, POLE4, PDE6D, POLR1A, PKM, GMPR2, POLR3C, NPR1, NME1, ENTPD6, ENTPD3",0.400116927926312,0.105130343254747,FALSE +"H1975","Input","KEGG_PYRIMIDINE_METABOLISM",0.41103,1.28,0.142,5239,0.494,"POLD4, CDA, NME5, UPP1, POLD2, POLR2E, NME7, POLR3H, POLR2J, NT5C2, PNP, POLR2F, UMPS, UPRT, CMPK2, POLR3G, TYMP, PRIM1, NT5M, UCK2, POLR3A, NME2, ITPA, POLR2H, DHODH, TK2, POLR3GL, POLE3, RRM2, POLE2, ENTPD5, POLR1C, NT5E, NME3, NME6, POLR1E, POLE4, POLR1A, CAD, POLR3C, DTYMK, NME1, ENTPD6, ENTPD3",0.847711655616944,0.306273051076353,FALSE +"H1975","Input","KEGG_PYRUVATE_METABOLISM",0.51518,1.63,0.0254,3486,0.336,"LDHC, PC, LDHD, LDHA, ALDH9A1, MDH2, DLD, AKR1B1, PDHA1, ACAT1, LDHAL6B, ALDH1B1, ME3, HAGHL, PDHB",1.59516628338006,0.473660722610156,FALSE +"H1975","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.27955,0.895,0.614,5366,0.852,"PPP1CA, VAV1, MAP2K2, MYLK2, LIMK1, PAK6, RAC2, GNA12, ARAF, ITGA5, ITGA2B, PAK2, ARPC1A, PIP5K1C, ITGB3, ACTN1, MYLK, RAC1, ACTB, CRK, ARPC1B, PIP4K2C, PAK1, ENAH, ITGB2, F2R, DIAPH1, TMSB4X, DIAPH2, IQGAP3, MYH9, MYL9, SSH3, MSN, PIP4K2A, ITGAE, RRAS2, MYL7, PIK3R2, FGF1, FGD1, MRAS, SSH2, CFL2, APC, TIAM1, PIK3CA, PPP1CB, WASL, FGF13, MAPK1, BCAR1, ITGA3, RHOA, PIK3CB, FN1, MYH10, VAV2, VCL, EGFR, ROCK2, IQGAP1, ITGA2, BRAF, DOCK1, GNA13, ITGB1, ITGAX, TIAM2, ARPC5L, ARPC4",0.211831628858832,0.0695604052332999,FALSE +"H1975","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.22708,0.7,0.88,5419,0.959,"ATG7, ATG12, ATG4A, PIK3R4, PRKAA1, GABARAP, ATG3, PIK3C3, BECN1, ULK2",0.0555173278498314,0.0181813928293364,FALSE +"H1975","Input","KEGG_RENAL_CELL_CARCINOMA",0.26049,0.825,0.715,4320,0.926,"MAP2K2, PAK6, EGLN3, ARAF, PAK2, HIF1A, FLCN, EGLN1, RAC1, CRK, PAK1, MET, PIK3R2, TGFB2, PIK3CA, EPAS1, MAPK1, PIK3CB, TGFB3, ETS1",0.145693958198919,0.0333890133180656,FALSE +"H1975","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.5803,1.82,0.00927,1975,0.487,"ANPEP, THOP1, AGT, CTSA, NLN, CTSG",2.0329202658555,0.312471038785366,FALSE +"H1975","Input","KEGG_RETINOL_METABOLISM",0.30349,0.951,0.511,2503,0.853,"CYP2C9, CYP2C8, AWAT2, RDH11, DHRS4, CYP26B1, RETSAT, DHRS4L2",0.291579099865287,0.069050968832477,FALSE +"H1975","Input","KEGG_RIBOFLAVIN_METABOLISM",0.42251,1.31,0.134,2422,0.521,"ACP5, ACP6, FLAD1",0.872895201635192,0.283162276700476,FALSE +"H1975","Input","KEGG_RIBOSOME",-0.18877,-0.702,0.89,16443,0.949,"RPS20, RPLP0, RPL9, RPL11, RPL6, RPS6, RSL24D1, RPL18, RPS27A, RPS8, RPL4, RPS4Y1, RPL21, RPL13A, RPS11, RPS16, RPS19",0.0506099933550872,0.0227337875727074,FALSE +"H1975","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.36806,1.13,0.269,4513,0.663,"IL12B, MAVS, TRIM25, PIN1, ATG12, CYLD, TRAF3, FADD, ISG15, TRADD, CASP8, CASP10, DDX58, DHX58, RNF125, MAPK12, CHUK, IKBKG, MAPK13, TBKBP1, AZI2, DDX3X, NLRX1, RIPK1",0.570247719997592,0.178486471595227,FALSE +"H1975","Input","KEGG_RNA_DEGRADATION",0.31907,1.01,0.418,7135,0.797,"LSM7, CNOT3, PAPOLA, LSM5, EDC4, CNOT4, HSPD1, MPHOSPH6, CNOT10, CNOT7, ENO1, XRN2, EXOSC7, CNOT6, PARN, EXOSC2, EXOSC3, SKIV2L, TTC37, LSM8, ENO2, EXOSC5, PATL1, LSM3, CNOT1, HSPA9, LSM4, EXOSC1, DCP1A, CNOT6L, ZCCHC7, PAPOLB",0.378823718224965,0.0985416786038876,FALSE +"H1975","Input","KEGG_RNA_POLYMERASE",0.33649,1.06,0.367,4966,0.736,"POLR2E, POLR3H, POLR2J, POLR2F, POLR3G, POLR3A, POLR2H, POLR3GL, POLR1C, POLR1E, POLR1A, POLR3C",0.435333935747911,0.133122185662501,FALSE +"H1975","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.31331,0.975,0.453,4567,0.83,"PAPSS2, HEMK1, AHCY, METTL6, METTL2B, SEPHS1, SCLY, GGT7",0.343901797987168,0.0809219076239261,FALSE +"H1975","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.32651,-1.22,0.182,16569,1,"E2F3, IKBKB, APAF1, PTGS2, PIAS1, LAMA5, COL4A4, NFKBIA, TRAF6, LAMA2, LAMC3, LAMA1, E2F2, BCL2, PIK3CD, RARB, FHIT, PTK2, AKT3, LAMA4, CASP9, BIRC3, PIK3R1, COL4A1, RB1, COL4A2, LAMB1, AKT2",0.739928612014925,0,FALSE +"H1975","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.42031,1.3,0.117,4374,0.501,"VTI1B, STX10, USE1, STX8, VTI1A, VAMP7, YKT6, SNAP47, VAMP8, STX4, SNAP29, STX1A, SNAP23, STX3, STX1B",0.931814138253838,0.300162274132754,FALSE +"H1975","Input","KEGG_SPHINGOLIPID_METABOLISM",0.35951,1.12,0.288,7055,0.678,"SPTLC2, GALC, SGPP1, SPHK1, PLPP2, SGMS2, SGMS1, GBA, GLA, SMPD4, UGCG, NEU1, NEU3, KDSR, PLPP3, B4GALT6, ASAH2, SPTLC1, SGPL1, SMPD1, ARSA",0.540607512240769,0.168770306132937,FALSE +"H1975","Input","KEGG_SPLICEOSOME",0.33022,1.02,0.393,5449,0.791,"PRPF31, SNW1, CTNNBL1, LSM7, RBM8A, ISY1, PQBP1, PRPF8, DHX38, HNRNPM, SNU13, HSPA1A, LSM5, PLRG1, U2AF2, SNRPB, RBM25, SRSF6, NCBP1, HSPA2, SF3B3, EFTUD2, CRNKL1, PRPF4, U2SURP, HSPA1B, HSPA8, BUD31, PPIL1, SLU7, DDX46, PRPF19, SNRPB2, SF3B4, SRSF1, SRSF5, SMNDC1, PRPF3, SF3A2, HNRNPK, XAB2, LSM8, PRPF6, SNRPD3",0.405607449624573,0.101823516502323,FALSE +"H1975","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.38786,1.21,0.2,4362,0.57,"GCK, PGM2L1, PYGL, HK2, PYGB, GBE1, PGM2, UGDH, HK1",0.698970004336019,0.244125144327509,FALSE +"H1975","Input","KEGG_STEROID_BIOSYNTHESIS",0.35022,1.09,0.325,1600,0.692,"LIPA, SOAT1, NSDHL",0.488116639021126,0.159893905543242,FALSE +"H1975","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.29429,0.926,0.566,1748,0.858,"CYP11B1, CYP1B1, HSD17B6, STS",0.247183568811729,0.0665127121512946,FALSE +"H1975","Input","KEGG_SULFUR_METABOLISM",0.30808,0.959,0.502,5223,0.843,"SULT1A4, PAPSS2, CHST11, SUOX, CHST12, SULT2B1, BPNT1",0.299296282854981,0.0741724253752577,FALSE +"H1975","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.37457,1.19,0.218,3754,0.597,"GRIN2A, C4B, C4A, C3, ACTN1, CTSG, CD40, SNRPB, TRIM21, C1R",0.661543506395395,0.224025668870631,FALSE +"H1975","Input","KEGG_TASTE_TRANSDUCTION",-0.1951,-0.719,0.847,12258,0.997,"TAS2R41, TAS2R8, PLCB2, PRKACG, GRM4, TAS1R2, TAS2R20, SCNN1A, ADCY8, TAS2R39, SCNN1G, GNAS, SCNN1B, TAS2R3, TAS2R38, TAS2R1, ASIC2, ADCY4, PDE1A, TAS2R46, TAS2R31, TAS2R10, TAS2R43, PRKACB, GNB1, ADCY6",0.0721165896692931,0.00130484168834428,FALSE +"H1975","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.28783,-1.07,0.3,13732,1,"BAAT, GGT5, GGT6, CDO1",0.522878745280338,0,FALSE +"H1975","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.31798,0.99,0.442,2018,0.82,"PMVK, ACAT1",0.354577730650908,0.0861861476162833,FALSE +"H1975","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28547,0.901,0.618,6241,0.855,"PPP2R1A, RPS6KB2, THBS3, AMH, SMURF1, NOG, MYC, BMP2, CUL1, RBL1, TGFB2, LTBP1, MAPK1, RHOA, E2F4, CDKN2B, TGFB3, BMPR1B, BMP4, ID4, ROCK2, SMAD4, BMPR2, EP300, SMAD3, SKP1, TGFBR1, ACVR2B, THBS1, BMPR1A, PPP2R1B, TGFBR2, ACVR1",0.209011524911184,0.0680338852718274,FALSE +"H1975","Input","KEGG_THYROID_CANCER",0.35496,1.09,0.329,3888,0.692,"MAP2K2, MYC, TP53, PPARG, NCOA4, TPM3, CDH1, RXRA, MAPK1",0.482804102050026,0.159893905543242,FALSE +"H1975","Input","KEGG_TIGHT_JUNCTION",-0.18358,-0.669,0.937,16463,0.923,"EPB41, SYMPK, ACTN2, VAPA, IGSF5, MAGI2, CSNK2B, PARD6B, HCLS1, JAM2, PPP2CA, PPP2R2B, PRKCQ, EPB41L3, HRAS, PPP2R2C, MYL12B, AMOTL1, JAM3, RAB3B, AKT3, PARD6A, CLDN1, KRAS, MPDZ, AKT2",0.0282604091122217,0.0347982989740879,FALSE +"H1975","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.27278,0.862,0.663,4088,0.883,"IL12B, TLR5, MAP2K2, TICAM2, LY96, TRAF3, RAC1, MAP2K4, FADD, IRAK1, IRF5, CASP8, CD40, MAP2K7, IRAK4, PIK3R2, MAPK12, CHUK, IKBKG, PIK3CA, TAB1, MYD88, MAPK1, MAPK13, TICAM1, PIK3CB",0.178486471595227,0.0540392964224314,FALSE +"H1975","Input","KEGG_TRYPTOPHAN_METABOLISM",0.43105,1.34,0.125,4414,0.517,"GCDH, CYP1B1, ALDH9A1, AADAT, ECHS1, ACAT1, MAOB, ALDH1B1, HADHA, AOX1, OGDH, CAT, MAOA, EHHADH, KYNU",0.903089986991944,0.286509456906058,FALSE +"H1975","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29726,0.908,0.581,4362,0.883,"GCK, CACNA1B, CACNA1A, INSR, HK2, PIK3R2, IRS1, PIK3CA, MAPK1, PRKCD, PIK3CB, HK1",0.235823867609669,0.0540392964224314,FALSE +"H1975","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.23394,0.732,0.833,112,0.979,"IL12B",0.0793549985932124,0.00921730819686218,FALSE +"H1975","Input","KEGG_TYROSINE_METABOLISM",0.44898,1.39,0.0809,3072,0.474,"ALDH3B1, GSTZ1, AOC2, NAA80, ALDH3B2, AOC3, MIF, HEMK1, MAOB, METTL6, GOT2, AOX1, METTL2B",1.09205147838773,0.324221658325915,FALSE +"H1975","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.17955,-0.702,0.931,15555,0.949,"FYN, NRAS, PAK3, TNF, CDC42, IL5, PPP3R1, IKBKB, MAPK11, CD4, MAP3K7, NFKBIA, PLCG1, NCK2, PRKCQ, PIK3CD, HRAS, AKT3, PIK3R1, PAK4, KRAS, NFKBIB, NFKBIE, AKT2",0.0310503190186574,0.0227337875727074,FALSE +"H1975","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.25737,0.8,0.74,6465,0.949,"UBA6, KEAP1, CUL4B, SMURF1, FZR1, PPIL2, HUWE1, STUB1, UBE2D1, UBA7, CUL1, FBXO2, UBE2F, BRCA1, UBE2S, UBE2D4, WWP2, PIAS4, TRIM37, CDC20, UBE2M, HERC4, PIAS2, PIAS3, UBE2L3, XIAP, UBE2C, ITCH, UBE2H, NHLRC1, UBE3C, MID1, PRPF19, UBE2E3, UBE2O, UBA1, UBE2Q1, CDC27, ERCC8, UBE2L6, ANAPC2, CBLC, BTRC, CUL7, CDC34, FBXO4, TRIM32, ANAPC1, UBE2K, SKP1, SIAH1, TRIP12, SOCS3, NEDD4L, MGRN1, BIRC6, UBE4A, UBE2I, CDC26, UBE2G1, CDC23",0.130768280269024,0.0227337875727074,FALSE +"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.56066,1.74,0.0163,3486,0.327,"LARS2, IARS2, PDHA1, PDHB",1.78781239559604,0.485452247339714,FALSE +"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.45051,1.41,0.0795,4656,0.487,"ALDH9A1, HIBADH, ACAA1, DLD, ECHS1, ACAT1, ALDH1B1, HADHA, AOX1, IVD, OXCT1, HSD17B10, PCCB, ACADSB, EHHADH, MCCC2, ACAA2",1.09963287134353,0.312471038785366,FALSE +"H1975","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.23538,0.737,0.854,4060,0.98,"PPP1CA, RAMP1, MAP2K2, MYLK2, PLA2G2C, CALM1, GNA12, ARAF, ADCY7, GNA11, ADORA2B, EDNRA, ADORA2A, MYLK, PRKCA, MYL9, ITPR1, PRKACA, PPP1CB, CALD1, MYL6, MAPK1, PRKCD, PLA2G12A, RHOA",0.068542129310995,0.00877392430750515,FALSE +"H1975","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.3188,0.995,0.445,6423,0.817,"CREB3L3, CREB3L1, DYNC1H1, RAB11B, DYNC2H1, DYNLL2, PRKACA, CREB5, STX4, DCTN2, CREB3L2, CREB3L4, NSF, CREB1, DYNC1LI1, DYNC1I2, RAB5C, DCTN1, RAB5B, PRKX, ADCY9",0.351639989019068,0.0877779434675845,FALSE +"H1975","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.23242,0.721,0.862,4088,0.971,"NOS3, MAP2K2, PLA2G2C, RAC2, MAPKAPK3, HSPB1, RAC1, SPHK1, PRKCA, PIK3R2, MAPK12, PIK3CA, PPP3CA, NFATC3, MAPK1, MAPK13, PLA2G12A, PIK3CB",0.0644927341752872,0.0127807700919951,FALSE +"H1975","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.27487,0.854,0.674,6423,0.891,"ATP6V0D2, ERO1A, ATP6V0D1, TJP2, ACTB, PRKCA, ATP6V1D, PRKACA, ATP6V1F, ATP6V1E2, TCIRG1, ATP6V0E2, PLCG2, KDELR3, SEC61G, ARF1, ATP6V1E1, SEC61A1, TJP1, ATP6V0E1, ACTG1, PDIA4, ATP6V1C1, ATP6V1B2, PRKX, KDELR2, ADCY9",0.17134010346468,0.0501222959631252,FALSE +"H1975","Input","KEGG_VIRAL_MYOCARDITIS",0.32969,1.03,0.388,4251,0.785,"MYH15, RAC2, RAC1, ACTB, ABL2, CASP8, CD40, ITGB2, CAV1, MYH9, EIF4G1, ICAM1, CYCS, DAG1, MYH10",0.411168274405793,0.105130343254747,FALSE +"H1975","Input","KEGG_WNT_SIGNALING_PATHWAY",0.20679,0.648,0.939,4060,0.982,"WNT9A, PPP2R1A, PPP2R5E, PRICKLE2, FZD9, RAC2, MYC, DAAM1, TP53, PPARD, FZD2, CUL1, PRICKLE1, TBL1X, RAC1, PPP2R5C, DVL2, PRKCA, RUVBL1, PRKACA, PSEN1, WNT7B, APC, PPP3CA, GSK3B, NFATC3, CTBP2, FOSL1, DKK1, RHOA",0.0273344077338891,0.00788851221305034,FALSE +"H1648","Input","KEGG_ABC_TRANSPORTERS",0.39832,1.22,0.187,4466,0.62,"ABCC5, ABCA12, ABCC2, ABCB9, ABCA7, ABCA13, ABCC3, ABCB6, ABCD1, TAP2, ABCA1, ABCB11, ABCC1, ABCG1",0.728158393463501,0.207608310501746,FALSE +"H1648","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.38703,1.16,0.229,5702,0.672,"IKBKB, PML, JUP, BRAF, PIK3CB, RUNX1, EIF4EBP1, MAP2K1, RPS6KB2, BAD, NFKB1, PIK3CA, MYC, MTOR, IKBKG, PIM1, STAT5A, CEBPA, RELA, RAF1, STAT5B, TCF7, CCND1, MAP2K2",0.640164517660112,0.172630726946175,FALSE +"H1648","Input","KEGG_ADHERENS_JUNCTION",-0.25687,-0.941,0.465,17254,0.798,"FER, RHOA, CTNNA1, SSX2IP, TCF7L1, PTPRM, FYN, WASF3, NECTIN3, TGFBR1, FGFR1, WASF2, CDC42, SMAD2",0.332547047110046,0.0979971086492706,FALSE +"H1648","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.30752,0.92,0.583,5333,1,"NFKBIA, IKBKB, TRADD, NFKBIE, MAPK9, ACSL5, TRAF2, TNFRSF1B, MAPK10, TNF, NFKB1, CAMKK1, STK11, RXRA, MTOR, IKBKG, RELA, IRS1, PRKAB1, CPT1C, CAMKK2, CPT1A, ACSL1",0.234331445240986,0,FALSE +"H1648","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.39667,1.17,0.236,4648,0.672,"IL4I1, NIT2, GLUD1, GAD1, ASL, DDO, ACY3, GLUL, ASS1, CAD, GLS2",0.627087997029893,0.172630726946175,FALSE +"H1648","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.42261,1.27,0.141,5399,0.596,"SCNN1G, SCNN1B, SCNN1A, PIK3CB, SLC9A3R2, SFN, PIK3CA, HSD11B1, HSD11B2, INSR, ATP1B3, IRS1, ATP1A3, ATP1B1",0.85078088734462,0.224753740259764,FALSE +"H1648","Input","KEGG_ALLOGRAFT_REJECTION",0.27671,0.827,0.734,2957,1,"CD40, TNF",0.134303940083929,0,FALSE +"H1648","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.37999,1.14,0.269,5121,0.688,"PLA2G4E, PLA2G4B, PLA2G10, PLA2G12A, PLA2G2F, ACOX1",0.570247719997592,0.162411561764489,FALSE +"H1648","Input","KEGG_ALZHEIMERS_DISEASE",-0.25911,-0.907,0.524,17647,0.826,"UQCRQ, ITPR2, NDUFB3, PLCB4, COX7A2, ATF6, NDUFA8, NDUFA7, NDUFA4, NDUFS4, GNAQ, CALM3, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, APBB1, APAF1, COX6B1, PPP3CB, BACE1, NDUFB2, SDHC, PPP3R1, ATP5MC2, NDUFS5",0.280668713016273,0.0830199526796178,FALSE +"H1648","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.33516,-1.17,0.223,16304,0.632,"VARS2, IARS2, NARS2, SARS2, WARS2, PSTK, RARS2, FARS2",0.651695136951839,0.199282921717615,FALSE +"H1648","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.22266,-0.843,0.757,16450,0.853,"PMM2, NANP, GMPPA, NANS, PMM1, CYB5R3, GNPDA2, GFPT1, UGP2, UAP1",0.120904120499927,0.069050968832477,FALSE +"H1648","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.2113,-0.756,0.819,18004,0.914,"BCL2, ALS2, MAP2K6, MAPK14, APAF1, PPP3CB, PPP3R1",0.0867160982395816,0.0390538042661686,FALSE +"H1648","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.32656,0.981,0.458,5251,0.936,"PSME2, CD74, CTSS, PSME1, CIITA, CANX, IFI30, B2M, TAP2, HSPA1B, HSPA1A, LGMN, TAPBP, PSME3, HSPA4, CTSB, TAP1",0.339134521996131,0.0287241512618947,FALSE +"H1648","Input","KEGG_APOPTOSIS",0.36086,1.09,0.326,4360,0.756,"NFKBIA, IRAK2, BIRC3, IKBKB, IL1A, TRADD, DFFA, CAPN1, PIK3CB, TNFRSF10A, CHP2, TRAF2, IRAK1, MAP3K14, BAD, TNF, MYD88, NFKB1, IL1R1, PRKAR1B, PIK3CA, TNFSF10, TNFRSF10D, TNFRSF10C, CYCS, IKBKG, CFLAR, TNFRSF10B",0.486782399932061,0.121478204498793,FALSE +"H1648","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.54704,1.63,0.0244,4164,0.694,"CYP4F3, PLA2G4E, CYP2E1, GPX2, GGT6, CYP2J2, PTGS1, AKR1C3, LTC4S, GGT1, GPX3, PLA2G4B, PLA2G10, CYP2C18, LTA4H, GGT7, PTGES2, ALOX12B, EPHX2, CBR3, CBR1, PLA2G12A",1.61261017366127,0.158640529545145,FALSE +"H1648","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.33383,1.01,0.427,4888,0.885,"PYCR3, AMD1, CKMT1A, CKMT1B, SAT1, GLUD1, AZIN2, ASL, NOS3, PRODH, GLUL, OAT, MAOA, AOC1, ASS1, GLS2, ALDH3A2, NAGS",0.369572124974976,0.0530567293021746,FALSE +"H1648","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.25143,0.765,0.812,3332,1,"ITGB6, CACNB1, ITGA2, JUP, ITGB4, ITGB8, DSC2, LAMA2, PKP2, CACNA1F, CACNB4, DSP, ITGAV, DSG2",0.0904439707588247,0,FALSE +"H1648","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.32225,-1.14,0.282,18443,0.593,"ALDH1B1, ALDH9A1",0.549750891680639,0.226945306635737,FALSE +"H1648","Input","KEGG_ASTHMA",0.29661,0.882,0.636,2957,1,"CD40, TNF",0.196542884351586,0,FALSE +"H1648","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.24092,0.716,0.869,1371,0.997,"CD40, TSHB",0.0609802235513335,0.00130484168834428,FALSE +"H1648","Input","KEGG_AXON_GUIDANCE",0.26975,0.807,0.761,3063,1,"RND1, PLXNA1, NCK1, MET, SEMA4A, NFATC4, PAK6, SEMA7A, SRGAP3, EPHB3, SEMA4B, EPHA1, PLXNB3, PAK2, RAC2, CHP2, PLXNA2, UNC5A, SEMA3B, EPHA2, PLXNB1, PAK1, ABLIM3, RHOD, EFNA1, LIMK2, PTK2, PLXNB2",0.118615343229427,0,FALSE +"H1648","Input","KEGG_BASAL_CELL_CARCINOMA",0.23492,0.717,0.879,2540,1,"WNT9A, DVL1, DVL3, WNT7A, WNT10A, BMP2, FZD5",0.0560111249262281,0,FALSE +"H1648","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.3335,-1.18,0.196,17073,0.694,"GTF2B, GTF2A1, TAF9, STON1, TAF1, TAF11, TAF9B, TAF12",0.707743928643524,0.158640529545145,FALSE +"H1648","Input","KEGG_BASE_EXCISION_REPAIR",0.4702,1.41,0.0768,5907,0.494,"MUTYH, POLB, NEIL1, MBD4, POLL, PARP3, POLD4, SMUG1, PARP2, POLE2, UNG, POLE, APEX1, OGG1",1.11463877996849,0.306273051076353,FALSE +"H1648","Input","KEGG_BETA_ALANINE_METABOLISM",-0.36707,-1.32,0.156,18214,0.733,"HIBCH, SMS, ACADM, ALDH1B1, ALDH9A1",0.806875401645538,0.134896025358872,FALSE +"H1648","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.32236,-1.19,0.209,17624,0.78,"ELOVL2, FADS2, ACOT7, HACD1",0.679853713888946,0.10790539730952,FALSE +"H1648","Input","KEGG_BLADDER_CANCER",0.45711,1.4,0.0881,1484,0.474,"MMP9, FGFR3, E2F1, CXCL8, MMP1, CDH1, EGF, VEGFC, BRAF",1.05502409158795,0.324221658325915,FALSE +"H1648","Input","KEGG_BUTANOATE_METABOLISM",0.24511,0.735,0.85,2914,1,"AKR1B10, BDH1, L2HGDH, GAD1, AACS",0.0705810742857073,0,FALSE +"H1648","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.39009,1.16,0.248,4804,0.672,"NFKBIA, CARD11, IKBKB, DAPP1, LYN, PLCG2, NFATC4, NFKBIE, PIK3CB, RAC2, PTPN6, CHP2, PIK3AP1, MAP2K1, VAV1, SYK, NFKB1, PIK3CA, BLNK, BCL10, IKBKG, NFATC2, VAV3, RAC1, RELA, NFAT5, CD72",0.605548319173784,0.172630726946175,FALSE +"H1648","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.27697,0.846,0.689,3884,1,"DRD5, HTR7, LTB4R2, VDAC3, GNA15, PTAFR, P2RX5, PLCG2, ADRA1B, ADRB2, CALML6, GRIN2D, RYR3, ADCY4, CHP2, PLCB3, GRIN1, CHRM3, PTK2B, ADORA2A, P2RX6, SLC25A5, NOS3, CACNA1F, SLC25A31, ADCY3, SPHK1, CALML5, ERBB3, PHKG2, P2RX4, ATP2A2, ITPR3",0.161780778092374,0,FALSE +"H1648","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.20876,0.629,0.952,2974,1,"UQCRFS1, COX6B2, CACNB1, TNNI3, COX5A, CYC1, UQCRHL, CACNA1F, CACNB4, UQCRB",0.0213630516155257,0,FALSE +"H1648","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.42651,1.28,0.136,2286,0.604,"CLDN18, CD6, ITGAM, CLDN9, SELL, SELP, CLDN10, CLDN8, NECTIN1, ICOSLG, CDH3, CLDN20, CD40, ITGB2, CDH1, CLDN7, CLDN3, ITGB8, CLDN23, CLDN4, NRCAM, ICAM2, CLDN1, OCLN, SDC1",0.866461091629782,0.218963061378868,FALSE +"H1648","Input","KEGG_CELL_CYCLE",-0.28219,-1.05,0.389,16874,0.712,"MAD2L2, CDC23, CDC25B, CCND2, E2F2, CDKN2D, SMC3, YWHAE, ABL1, ORC3, BUB3, SMC1A, SKP1, SKP2, CCNH, CDKN2B, RBX1, DBF4, CDKN2A, ORC2, CDKN2C, TFDP1, ANAPC13, CDC25C, CDC16, ANAPC10, SMAD2",0.410050398674292,0.147520006363144,FALSE +"H1648","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.41843,1.26,0.156,3342,0.574,"CXCL10, CXCL9, CXCL11, CXCL6, CXCL3, CX3CL1, CCL5, NFKBIA, CCL22, CCR3, CXCL1, CXCL2, CCL20, IKBKB, LYN, CCL28, PF4, CCL17, CXCL8, GRK6, CCL19, FOXO3, CXCL16, BRAF, PIK3CB, GRK7, PPBP, CCL3, RAC2, GRK2, ADCY4, PLCB3, MAP2K1, PTK2B, VAV1, PAK1, CCL26, ADCY6, PRKCZ, TIAM1, PTK2, CSK, ADCY3, NFKB1, CXCR6, STAT2, CCR7, CCL3L3",0.806875401645538,0.241088107602027,FALSE +"H1648","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.33339,1.01,0.424,5756,0.885,"NFKBIA, IKBKB, E2F1, BCR, SMAD3, BRAF, PIK3CB, RUNX1, CBLC, MAP2K1, HDAC2, MECOM, BAD, TGFB3, NFKB1, PIK3CA, MYC, TGFBR2, IKBKG, STAT5A, RELA, TGFB2, CDK6, RAF1, HDAC1, STAT5B, BCL2L1, TGFB1, CCND1, MAP2K2, SHC2",0.372634143407267,0.0530567293021746,FALSE +"H1648","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.47974,1.43,0.0727,3056,0.549,"NR1D1, BHLHE41, BHLHE40, PER1, CSNK1E",1.13846558914096,0.260427655549908,FALSE +"H1648","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.31856,-1.14,0.235,18284,0.593,"MDH1, OGDH, ACO1, SDHC",0.628932137728264,0.226945306635737,FALSE +"H1648","Input","KEGG_COLORECTAL_CANCER",-0.23639,-0.806,0.763,17100,0.864,"AXIN2, RHOA, APC, TCF7L1, BCL2, PIK3R1, AKT3, TGFBR1, MAPK8, SMAD2",0.11747546204512,0.0634862575211067,FALSE +"H1648","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.37195,1.12,0.263,4100,0.719,"C9, CFB, THBD, PROC, C5AR1, PLAU, SERPINF2, VWF, PLAT, C3, F5, F3, F12, FGG, PLAUR, SERPINA5, CFH, SERPINA1",0.580044251510242,0.143271109617117,FALSE +"H1648","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.28336,0.855,0.685,879,1,"AHCY, IL4I1, AMD1, SDS",0.164309428507574,0,FALSE +"H1648","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.51645,1.56,0.0392,3922,0.635,"CXCL10, IFNL1, IFNL3, CRLF2, IFNB1, CXCL9, CXCL11, IFNL2, CXCL6, CXCL3, CX3CL1, CCL5, IL23A, CCL22, IFNGR1, CSF2, CCR3, IL1R2, LTB, CXCL1, TNFSF18, CD27, TNFRSF18, CXCL2, CCL20, CSF3, IL20RA, CCL28, PF4, IL9R, CCL17, MET, CXCL8, IL1A, BMPR1B, IL4R, CD40, CCL19, TNFRSF21, CXCL16, BMP7, EGF, VEGFC, IL15RA, TNFRSF10A, TNFSF13, CSF2RA, PPBP, CCL3, IL6, BMP2, IL18, IL10RB, INHBE, TNFRSF14, TNFRSF1B, IFNLR1, CSF1, IL19, CCL26, PDGFB, AMH, NGFR, TNFSF15, TNF, PDGFA, TGFB3, CXCR6, IL1R1, CCR7, IL20RB, CSF1R, CCL3L3, TNFSF14, LTBR, IL22RA1, IFNAR2, LIF, RELT, TGFBR2, INHBB, TNFSF10, TNFRSF10D",1.40671393297954,0.197226274708024,FALSE +"H1648","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.56446,1.67,0.0213,2184,0.92,"CXCL10, IFNB1, RIPK3, CCL5, NFKBIA, DDX58, IKBKE, IKBKB, IRF7, IL6, IRF3, IL18",1.67162039656126,0.0362121726544447,FALSE +"H1648","Input","KEGG_DILATED_CARDIOMYOPATHY",0.22268,0.666,0.927,3111,1,"ITGB6, CACNB1, TNNI3, ITGA2, ITGB4, ITGB8, ADCY4, LAMA2, ADCY6, CACNA1F, CACNB4, TNF, ITGAV, TGFB3, ADCY3",0.0329202658555029,0,FALSE +"H1648","Input","KEGG_DNA_REPLICATION",0.272,0.83,0.734,5279,1,"RNASEH2C, RNASEH1, RFC4, POLD4, MCM2, RPA4, MCM5, MCM7, POLE2, RFC5, POLA2, POLE",0.134303940083929,0,FALSE +"H1648","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.39202,1.17,0.216,2350,0.672,"ETV6, ETV7, PIWIL4, NOTCH3, MAP2K1",0.665546248849069,0.172630726946175,FALSE +"H1648","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.31734,0.955,0.512,5269,0.965,"ADH7, CYP2E1, ALDH3A1, CYP2D6, ALDH1A3, GSTM1, GSTO2, CYP2C18, GSTT2, GSTK1, ALDH3B2, MGST1, MAOA, ADH1A, GSTP1, MGST2, GSTM3",0.290730039024169,0.0154726866562074,FALSE +"H1648","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.33408,0.999,0.445,4726,0.906,"XDH, UMPS, NAT1, UPP1, HPRT1, GMPS, GUSB, UCKL1, TYMP, CDA, IMPDH1",0.351639989019068,0.0428718023231869,FALSE +"H1648","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.28407,0.858,0.671,3805,1,"ITGB6, LAMC2, CHAD, LAMA3, ITGA2, AGRN, LAMB3, CD47, ITGB4, ITGB8, VWF, SDC1, THBS4, LAMA2, ITGAV, SDC4, LAMA5, THBS1, HMMR",0.173277479831008,0,FALSE +"H1648","Input","KEGG_ENDOCYTOSIS",0.323,0.971,0.485,4228,0.941,"ITCH, SRC, RAB11FIP1, CHMP4B, EPN3, TFRC, MET, FGFR3, CLTB, HGS, GRK6, SMURF1, ARAP1, ACAP3, EGF, ADRB2, ACAP2, ARAP3, RUFY1, GRK7, CHMP6, GRK2, VPS37B, PSD4, CBLC, RAB11FIP4, CHMP4C, IGF1R, IQSEC1, CLTA, ASAP2, ARAP2, VPS37C, PRKCZ, LDLR, CHMP4A, SH3GLB2, GIT1, ARF6, RAB11A, CSF1R, ERBB3, HSPA1B, AP2M1, HSPA1A, RAB22A, FGFR2, WWP1, ACAP1, AGAP2, DNM2",0.314258261397736,0.0264103765727431,FALSE +"H1648","Input","KEGG_ENDOMETRIAL_CANCER",0.18238,0.545,0.986,3622,1,"CDH1, FOXO3, EGF, BRAF, PIK3CB, MAP2K1, BAD, PIK3CA, MYC",0.0061230850587888,0,FALSE +"H1648","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.51814,1.55,0.0421,4862,0.534,"ATP6V0D2, CCL5, SRC, NFKBIA, ATP6V1C2, CXCL1, IKBKB, LYN, MET, CXCL8, PLCG2, ADAM17, MAPK9, TCIRG1, MAPK13, PTPRZ1, ATP6V0E1, HBEGF, TJP1, ATP6V0A2, PAK1, MAPK10, MAP3K14, ATP6V0B, F11R, ATP6V1H, CSK, NFKB1, GIT1, ATP6V0E2, NOD1, ATP6V1C1, ATP6V1A, IKBKG, ADAM10, RAC1, RELA, MAPK12, EGFR",1.37571790416433,0.272458742971444,FALSE +"H1648","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.39761,1.19,0.2,3664,0.688,"SRC, EREG, NCK1, BTC, AREG, PLCG2, PAK6, EGF, BRAF, PIK3CB, MAPK9, PAK2, EIF4EBP1, HBEGF, CBLC, TGFA, MAP2K1, PAK1, MAPK10, RPS6KB2, BAD, PTK2, ERBB3, PIK3CA, MYC, MTOR",0.698970004336019,0.162411561764489,FALSE +"H1648","Input","KEGG_ETHER_LIPID_METABOLISM",0.2868,0.869,0.664,5129,1,"PLA2G4E, LPCAT4, PLA2G4B, PLA2G10, PLPP3, PLPP2, PLA2G12A, AGPS, PLD2, PLA2G2F, LPCAT2, PLD1",0.177831920631982,0,FALSE +"H1648","Input","KEGG_FATTY_ACID_METABOLISM",-0.23858,-0.878,0.562,18120,0.841,"HADH, ACADM, ALDH1B1, ACAA2, ECI2, ALDH9A1",0.250263684430939,0.0752040042020878,FALSE +"H1648","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.31999,0.963,0.492,4757,0.953,"PLA2G4E, CSF2, LYN, PLCG2, PIK3CB, MAPK9, MAPK13, RAC2, PLA2G4B, PLA2G10, MAP2K1, VAV1, MAPK10, SYK, TNF, PIK3CA, PLA2G12A, LAT, PLA2G2F, VAV3, RAC1, PRKCD, MAPK12",0.30803489723264,0.0209070993616736,FALSE +"H1648","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.26203,0.782,0.794,5129,1,"PLA2G4F, PLA2G4E, LYN, PLCG2, PIK3CB, RAC2, PLA2G4B, MAP2K1, VAV1, PAK1, ASAP2, SYK, PLPP3, RPS6KB2, LIMK2, PLPP2, SPHK1, ARF6, PIK3CA, MYO10, DNM2, LAT, PLD2, PLA2G4D, VAV3, RAC1, PRKCD, WASL, RAF1, PLD1",0.100179497572904,0,FALSE +"H1648","Input","KEGG_FOCAL_ADHESION",0.25253,0.777,0.803,3032,1,"SRC, BIRC3, DIAPH1, ITGB6, MET, LAMC2, CHAD, LAMA3, ITGA2, LAMB3, PAK6, EGF, VEGFC, BRAF, PIK3CB, MAPK9, ITGB4, ITGB8, PAK2, RAC2, ARHGAP5, VWF, MAP2K1, VAV1, THBS4, LAMA2, CAV2, PAK1, IGF1R, MAPK10, PDGFB, BAD, ITGAV, PDGFA, PTK2",0.095284454721319,0,FALSE +"H1648","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.48535,-1.71,0.029,12183,0.21,"GGH, ALPI, GCH1, DHFR, ALPG, ALPP, ALPL",1.53760200210104,0.677780705266081,TRUE +"H1648","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.46895,1.41,0.087,5512,0.494,"AKR1B10, MTMR1, PFKL, FBP2, MPI, PFKFB4, ALDOC, GMPPB, PFKFB2, TPI1, KHK, ALDOA, GMDS, HK2, PFKFB3, AKR1B1, PFKP, HK1",1.06048074738138,0.306273051076353,FALSE +"H1648","Input","KEGG_GALACTOSE_METABOLISM",0.39746,1.17,0.235,6475,0.672,"GLA, GALT, PFKL, GANC, GAA, GALE, HK2, AKR1B1, PGM2, PFKP, HK1, B4GALT2, HK3, B4GALT1",0.628932137728264,0.172630726946175,FALSE +"H1648","Input","KEGG_GAP_JUNCTION",-0.2056,-0.74,0.806,14131,0.899,"PRKCB, MAPK1, TUBB6, DRD1, GNAS, TUBB2B, ADCY2, GUCY1B1, ADCY1, TUBB8, PDGFRA, DRD2, KRAS, GUCY1A2, MAPK7, TUBA3D, CDK1, TUBB4A, PRKG1, PDGFD, TUBA1B, PRKACA, PDGFRB, TUBA8, TUBB2A, ADCY9, PRKACB, ITPR2, PLCB4, TUBB3, LPAR1, TUBB, NRAS, GNAQ, GNAI1, TUBA1A",0.0936649581949093,0.0462403082667712,FALSE +"H1648","Input","KEGG_GLIOMA",0.24531,0.743,0.847,3664,1,"E2F1, PLCG2, EGF, BRAF, PIK3CB, CALML6, TGFA, MAP2K1, IGF1R, PDGFB, PDGFA, CALML5, PIK3CA, MTOR",0.0721165896692931,0,FALSE +"H1648","Input","KEGG_GLUTATHIONE_METABOLISM",0.44987,1.35,0.0964,3859,0.553,"G6PD, GPX2, GSS, GGT6, GSR, OPLAH, GGT1, PGD, GPX3, GSTM1, GSTO2, GSTT2, GCLM, GGCT, GGT7, GSTK1, MGST1",1.01592296609717,0.257274868695302,FALSE +"H1648","Input","KEGG_GLYCEROLIPID_METABOLISM",0.36643,1.1,0.292,5958,0.739,"DGAT1, LIPG, GLA, MBOAT2, DGKQ, AGPAT3, DGKA, DGAT2, AKR1A1, PLPP3, GPAT3, PLPP2, DGKG, DGKE, MBOAT1, CEL, DGKH, ALDH3A2, AGPAT2, AKR1B1, AGPAT4, TKFC, GLYCTK, GPAT4",0.534617148551582,0.131355561605174,FALSE +"H1648","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40692,1.23,0.177,4873,0.609,"PLA2G4E, PISD, LPCAT4, LYPLA1, PTDSS1, PCYT1A, CHKB, MBOAT2, PGS1, PLA2G4B, PLA2G10, DGKQ, AGPAT3, DGKA, PLPP3, GPAT3, PLPP2, DGKG, DGKE, MBOAT1, CDS1, PLA2G12A, GPD2, PCYT2, ACHE, DGKH, PLD2, PLA2G2F, LPCAT2, LYPLA2, AGPAT2",0.752026733638193,0.215382707367125,FALSE +"H1648","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.32615,-1.18,0.208,16750,0.694,"CTH, DMGDH, PHGDH, PSPH, GNMT, GLDC, PSAT1, SRR",0.681936665037238,0.158640529545145,FALSE +"H1648","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.3453,1.02,0.4,6874,0.88,"ADH7, ALDH3A1, ALDH1A3, PFKL, FBP2, AKR1A1, ALDOC, PKM, DLAT, ALDH3B2, GPI, TPI1, LDHAL6B, ALDOA, GAPDH, HK2, ALDH3A2, ADH1A, ACSS2, GALM, PGM2, PFKP, LDHB, HK1, ADH6, PGAM1, LDHA, HK3, ALDH2, PCK2, ALDH3B1, FBP1",0.397940008672038,0.0555173278498314,FALSE +"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.36842,1.1,0.307,3293,0.739,"B4GALT7, CHST11, B3GALT6, DSE, XYLT2, CHST15, CSGALNACT1",0.512861624522813,0.131355561605174,FALSE +"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.28866,0.863,0.664,3227,1,"HS3ST1, B4GALT7, HS6ST2, B3GALT6, XYLT2, EXT1",0.177831920631982,0,FALSE +"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.34764,1.05,0.361,3626,0.839,"B3GNT7, CHST6, CHST4, FUT8, B4GALT4",0.442492798094342,0.0762380391712997,FALSE +"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.43688,1.32,0.129,5562,0.572,"HYAL4, IDS, SGSH, GUSB, HGSNAT, HYAL3, HEXA, HYAL1, IDUA, NAGLU, HPSE",0.889410289700751,0.242603971206976,FALSE +"H1648","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.19525,-0.735,0.804,14842,0.886,"ST3GAL2, ST8SIA1, ST8SIA5, B4GALNT1, ST6GALNAC3",0.0947439512515487,0.0525662781129492,FALSE +"H1648","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.53022,1.57,0.0375,2720,0.686,"GLA, FUT2, B3GALT5, FUT1, A4GALT",1.42596873227228,0.163675884293248,FALSE +"H1648","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.49605,1.46,0.0511,3986,0.535,"ABO, B3GNT3, FUT3, FUT2, B3GALT5, B3GNT4, B3GNT5, FUT1, FUT4, B4GALT4, ST3GAL4, GCNT2",1.29157909986529,0.271646217978772,FALSE +"H1648","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.38619,1.17,0.227,4959,0.672,"PIGU, PIGB, PIGZ, PIGX, GPAA1, PIGQ, PIGS, PIGO, PIGL, PIGH, PIGW",0.643974142806877,0.172630726946175,FALSE +"H1648","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.60637,-2.19,0,17388,0.066,"MTHFD2, HYI, MDH1, ACO1, GRHPR",Inf,1.18045606445813,TRUE +"H1648","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.26855,0.808,0.784,5175,1,"MAP3K4, SRC, PLA2G4E, MAPK9, MAPK13, CALML6, ADCY4, PLA2G4B, PLCB3, PLA2G10, HBEGF, MAP2K1, PTK2B, MAPK10, ADCY6, CACNA1F, ADCY3, MMP14, CALML5, MAP3K2, ITPR3, PLA2G12A, LHB, PLD2, PLA2G2F, PRKCD, MAPK12, CAMK2G, EGFR, ADCY7, RAF1, PLD1, MAP3K1",0.105683937315562,0,FALSE +"H1648","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.38487,1.15,0.253,2957,0.673,"IL1A, IL6, TNF",0.596879478824182,0.171984935776023,FALSE +"H1648","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.21478,-0.746,0.855,16454,0.911,"BMP8A, BMP8B, HHIP, BMP6, PRKACA, WNT2B, GAS1, PRKACB, GLI2, SUFU, WNT5A, GLI3, CSNK1G3, RAB23",0.0680338852718274,0.0404816230270017,FALSE +"H1648","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.42186,1.26,0.148,3286,0.574,"ITGAM, CSF2, IL1R2, CSF3, TFRC, IL9R, IL1A, ITGA2, IL4R, CSF2RA, IL6, CD9, CSF1, TNF, IL1R1, CSF1R",0.829738284605043,0.241088107602027,FALSE +"H1648","Input","KEGG_HISTIDINE_METABOLISM",0.42285,1.27,0.133,4814,0.596,"LCMT1, ALDH3A1, ALDH1A3, TRMT11, HNMT, ACY3, ALDH3B2, HEMK1, MAOA, HAL, AOC1, ALDH3A2",0.876148359032914,0.224753740259764,FALSE +"H1648","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.41424,1.26,0.168,3359,0.574,"EME1, RAD51B, RAD51, MUS81, XRCC2, RAD51D, MRE11, RAD54L, POLD4, RAD54B, RPA4",0.774690718274137,0.241088107602027,FALSE +"H1648","Input","KEGG_HUNTINGTONS_DISEASE",-0.21836,-0.77,0.765,17299,0.91,"POLR2G, DCTN2, CLTCL1, CREB3L1, UQCRQ, RCOR1, HIP1, NDUFB3, PLCB4, PPARGC1A, COX7A2, AP2S1, BDNF, NDUFA8, CREB3L2, NDUFA7, NDUFA4, NDUFS4, GNAQ, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, APAF1, COX6B1, NDUFB2, SDHC, DCTN1, ATP5MC2, NDUFS5",0.116338564846382,0.0409586076789064,FALSE +"H1648","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.25701,0.772,0.794,3041,1,"ITGB6, CACNB1, TNNI3, ACE, ITGA2, ITGB4, ITGB8, IL6, LAMA2, CACNA1F, CACNB4, TNF, ITGAV, TGFB3",0.100179497572904,0,FALSE +"H1648","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.27439,0.82,0.742,5554,1,"INPP4A, PLCG2, IPMK, PIK3CB, INPP4B, PLCB3, SYNJ2, PIK3C2B, IPPK, PIK3C2G, PIK3CA, OCRL, TPI1, ISYNA1, INPP5K, PIP4K2C, PLCD3, INPP5E, INPPL1",0.129596094720973,0,FALSE +"H1648","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.21936,0.657,0.936,7068,1,"IKBKB, PYGL, BRAF, PIK3CB, MAPK9, MKNK1, CALML6, FOXO1, EIF4EBP1, FBP2, CBLC, MAP2K1, MAPK10, RPS6KB2, BAD, SH2B2, PRKCZ, CALML5, TRIP10, PTPRF, PRKAR1B, PHKG2, PIK3CA, MTOR, SOCS2, ACACA, INSR, MKNK2, IRS1, HK2, PRKAB1, INPP5K, SOCS1, PPP1R3D, PHKG1, RAF1, EXOC7, HK1, SOCS3, MAP2K2, SHC2, FASN, PHKA1, TSC2, SOS1, PRKCI, HK3, PRKAA1, CRKL, SOS2, GYS1, LIPE, INPP5D, PYGM, PRKAG2, PCK2, FBP1, FLOT2, PHKA2, CALM2",0.0287241512618947,0,FALSE +"H1648","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.51136,1.53,0.0375,4573,0.458,"PIGR, CCL28, ICOSLG, CD40, IL15RA, TNFSF13, IL6, MAP3K14, LTBR, MADCAM1, IL15",1.42596873227228,0.339134521996131,FALSE +"H1648","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.40928,1.23,0.167,4604,0.609,"IFNL1, IFNL3, CRLF2, IFNB1, IFNL2, IL23A, IFNGR1, CSF2, CSF3, IL20RA, IL9R, SPRY3, IRF9, IL4R, PIK3CB, IL15RA, CSF2RA, SPRY1, PTPN6, IL6, CBLC, IL10RB, IFNLR1, IL19, STAT6, TYK2, STAT2, IL20RB, PIK3CA, IL22RA1, MYC, IFNAR2, LIF, SOCS2, CCND3, IFNGR2, PIM1, JAK3, CLCF1, OSMR, STAT5A, IL15, SOCS7",0.777283528852417,0.215382707367125,FALSE +"H1648","Input","KEGG_LEISHMANIA_INFECTION",0.46633,1.42,0.0834,3125,0.546,"ITGAM, NFKBIA, IFNGR1, TLR2, IL1A, NCF4, ITGB2, TAB2, MAPK13, PTPN6, C3, IRAK1, CYBA, TNF, TGFB3, MYD88, NFKB1",1.07883394936226,0.262807357295263,FALSE +"H1648","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.42995,1.28,0.137,3977,0.604,"MMP9, CLDN18, ITGAM, CLDN9, CLDN10, CLDN8, NCF4, CLDN20, PLCG2, ITGB2, CLDN7, CTNND1, PIK3CB, CLDN3, AFDN, MAPK13, CLDN23, RAC2, CLDN4, ARHGAP5, CLDN1, OCLN, PTK2B, VAV1, EZR, RAPGEF3, F11R, CYBA, PTK2, SIPA1, PIK3CA, NOX1, NCF2, RASSF5, TXK, PXN",0.863279432843593,0.218963061378868,FALSE +"H1648","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.5,-1.76,0.0197,18443,0.212,"ALDH1B1, ALDH9A1",1.70553377383841,0.673664139071249,TRUE +"H1648","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.61142,1.85,0.0104,2088,0.461,"AKR1B10, PLA2G4E, CYP2E1, CYP2J2, PLA2G4B, PLA2G10, CYP2C18",1.98296666070122,0.336299074610352,FALSE +"H1648","Input","KEGG_LONG_TERM_DEPRESSION",0.18565,0.558,0.991,2608,1,"PLA2G4E, LYN, BRAF, PLA2G4B, PLCB3, PLA2G10, MAP2K1, IGF1R",0.00392634551472468,0,FALSE +"H1648","Input","KEGG_LONG_TERM_POTENTIATION",-0.27282,-1.01,0.438,16947,0.745,"CALM1, RAP1B, PRKACA, PRKACB, ITPR2, CAMK4, RPS6KA2, PLCB4, RPS6KA1, ATF4, NRAS, GNAQ, CALM3, PPP3CB, PPP3R1",0.3585258894959,0.127843727251707,FALSE +"H1648","Input","KEGG_LYSINE_DEGRADATION",-0.29843,-1.09,0.3,17259,0.675,"SETDB1, EHMT1, HADH, ALDH1B1, AASS, OGDH, ALDH9A1, NSD1",0.522878745280338,0.170696227168975,FALSE +"H1648","Input","KEGG_LYSOSOME",0.42184,1.25,0.179,6147,0.586,"CTSE, ATP6V0D2, AP3M2, GGA2, NAPSA, LAMP3, CTSS, GLA, LAPTM5, IDS, ABCB9, MANBA, CLTB, IGF2R, CD164, CTSH, GGA3, TCIRG1, AP3B2, GM2A, AP1S3, CTSV, ATP6V0A2, SGSH, CLTA, ATP6V0B, GUSB, SLC11A2, CTSA, ATP6V1H, AP4S1, AP1M2, HGSNAT, GAA, ENTPD4, MFSD8, SUMF1, CTSD, LGMN, ACP5, GNPTG, SORT1, HEXA, CTSB, HYAL1, IDUA, M6PR, MAN2B1, ATP6V0C, CTSC, NAGLU, ARSA, ARSG, NPC1, NPC2, AP3D1, PSAP, LAPTM4B, LIPA, GGA1, FUCA1, CLN5, CTSZ",0.747146969020107,0.232102383981909,FALSE +"H1648","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.28446,0.853,0.67,3822,1,"MAP3K4, PLA2G4E, IL1R2, FGF17, IKBKB, DUSP5, CACNB1, DUSP10, NFKB2, FGFR3, DUSP9, NTF4, IL1A, GADD45A, FGF11, FGF13, NFATC4, RELB, RASGRP1, TAB2, EGF, BRAF, MAPK9, MAPK13, MKNK1, MAP3K13, PAK2, RAC2, MAP3K8, RPS6KA4, PLA2G4B, CHP2, PLA2G10, MAP2K1, RASA2, TRAF2, DUSP7, PAK1, MAPK10, MAP3K14, MAPKAPK5, MAPKAPK3, MECOM, CACNA1F, MAPK8IP3, CACNB4, PDGFB, GADD45B, TNF, PDGFA, TGFB3, NFKB1, IL1R1, STK3, MAP3K2, MAP3K5, MAP4K1, HSPA1B, MYC, MAP4K4, TGFBR2, HSPA1A, FGFR2",0.173925197299174,0,FALSE +"H1648","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.43762,1.29,0.131,2498,0.614,"HES1, MNX1, HNF1B, HNF4G, FOXA2",0.882728704344236,0.211831628858832,FALSE +"H1648","Input","KEGG_MELANOGENESIS",0.20532,0.614,0.961,3376,1,"WNT9A, DVL1, DVL3, WNT7A, WNT10A, CALML6, ADCY4, PLCB3, MAP2K1, FZD5, ADCY6, ASIP, ADCY3, CALML5, CREB3, FZD6",0.0172766123314547,0,FALSE +"H1648","Input","KEGG_MELANOMA",0.30215,0.91,0.588,3017,1,"FGF17, MET, E2F1, FGF11, FGF13, CDH1, EGF, BRAF, PIK3CB, MAP2K1, IGF1R, PDGFB, BAD, PDGFA",0.230622673923862,0,FALSE +"H1648","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.43184,1.3,0.133,4142,0.606,"ADH7, CYP2E1, AKR1C2, CYP1A1, ALDH3A1, AKR1C3, ALDH1A3, GSTM1, GSTO2, CYP2C18, AKR1C1, GSTT2, CYP1B1, GSTK1, ALDH3B2, MGST1, CYP2S1",0.876148359032914,0.217527375833714,FALSE +"H1648","Input","KEGG_MISMATCH_REPAIR",-0.19457,-0.731,0.872,19056,0.871,"RPA2",0.0594835150674328,0.0599818449923368,FALSE +"H1648","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.26238,0.79,0.783,4058,1,"ULK1, RICTOR, VEGFC, BRAF, PIK3CB, EIF4EBP1, RPS6KB2, ULK3, STK11, PIK3CA, MTOR, HIF1A",0.106238237942057,0,FALSE +"H1648","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.32157,0.953,0.509,4750,0.959,"IFNB1, IFNGR1, CSF2, PLCG2, ITGB2, NFATC4, BRAF, PIK3CB, SH3BP2, TNFRSF10A, RAC2, ICAM2, PTPN6, CHP2, MAP2K1, PTK2B, VAV1, PAK1, SYK, TNF, LCK, PIK3CA, IFNAR2, TNFSF10, TNFRSF10D, IFNGR2, TNFRSF10C, TNFRSF10B, LAT, NFATC2, CD244, VAV3, RAC1, NFAT5",0.293282217663241,0.0181813928293364,FALSE +"H1648","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.34881,1.04,0.37,2809,0.857,"DRD5, GALR2, NPBWR1, GABRP, S1PR4, HTR7, P2RY6, MC3R, P2RY2, LTB4R2, LTB4R, GABRG2, MTNR1A, PTAFR, P2RX5, C5AR1, GABRE, S1PR5, TSHB, ADRA1B, ADRB2, GRIN2D, SSTR2, GRIN1, VIPR1, CHRM3, ADORA2A, PRSS1, P2RX6, GRIN3B, GIPR, CHRNB1, GABRA3",0.431798275933005,0.0670191780768018,FALSE +"H1648","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.24207,0.733,0.838,4853,1,"NFKBIA, IRAK2, IKBKB, NTF4, PLCG2, FOXO3, BRAF, NFKBIE, PIK3CB, MAPK9, MAPK13, CALML6, RPS6KA4, MAP2K1, IRAK1, PRDM4, MAPK10, BAD, NGFR, SH2B2, CSK, NFKB1, CALML5, PSEN1, MAP3K5, RIPK2, PIK3CA, ZNF274, SORT1, RAC1, RELA, IRS1, PRKCD, MAPK12, IRAK3, CAMK2G, YWHAZ",0.0767559813697235,0,FALSE +"H1648","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.32396,0.971,0.483,4624,0.941,"NADK, NAMPT, NADSYN1, NMNAT3, PNP, NT5C1B, NT5C2, QPRT, NT5E",0.316052869248488,0.0264103765727431,FALSE +"H1648","Input","KEGG_NITROGEN_METABOLISM",0.28304,0.848,0.694,4648,1,"CA13, CA7, GLUD1, GLUL, HAL, GLS2",0.158640529545145,0,FALSE +"H1648","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.48837,1.48,0.0682,3916,0.553,"CCL5, NFKBIA, BIRC3, CXCL1, TNFAIP3, CXCL2, IKBKB, CXCL8, TAB2, MAPK9, MAPK13, IL6, PSTPIP1, IL18, CARD6, MAPK10, NOD2, TNF, NFKB1, NLRP1, TAB3, RIPK2, NOD1, CARD9",1.16621562534352,0.257274868695302,FALSE +"H1648","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.3414,-1.23,0.175,15827,0.808,"XRCC6, XRCC4, NHEJ1, RAD50, XRCC5",0.756961951313706,0.0925886392254138,FALSE +"H1648","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.26511,0.801,0.763,5702,1,"E2F1, PLCG2, FOXO3, EGF, BRAF, PIK3CB, TGFA, MAP2K1, BAD, RXRA, PIK3CA, RASSF5, CDK6, EGFR, RAF1, CCND1, ERBB2, MAP2K2",0.11747546204512,0,FALSE +"H1648","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.51853,1.57,0.0287,2688,0.686,"DVL1, DVL3, DTX4, RFNG, DTX3L, JAG1, ADAM17, DLL1, HES1, HES5, NOTCH3, DTX2, JAG2, KAT2A, HDAC2",1.54211810326601,0.163675884293248,FALSE +"H1648","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.38986,-1.39,0.123,15123,0.636,"RFC1, XPA, GTF2H1, ERCC4, RAD23B, GTF2H4, RPA1, RFC2, ERCC1, RAD23A, ERCC6, ERCC2, ERCC8, CCNH, RBX1, XPC, CUL4A, RPA2",0.910094888560602,0.196542884351586,FALSE +"H1648","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.26447,0.798,0.776,4552,1,"ALG3, MGAT4B, RFT1, RPN2, RPN1, MGAT1, ALG10, ALG10B, FUT8, MAN2A2, MOGS, DPAGT1, MGAT2, TUSC3, ALG8",0.110138278741812,0,FALSE +"H1648","Input","KEGG_OLFACTORY_TRANSDUCTION",0.38106,1.15,0.252,1976,0.673,"OR4C6, OR2J3, OR5M11, OR8S1, OR6B2, OR13D1, OR1J1, OR4D2, OR13H1, OR10AD1, OR2A5, OR4L1, OR2D2, OR11H4, OR10K2, OR2A7, OR4X2, OR1G1, OR10H1, OR8G1, OR2A12, OR8B4, GUCY2D, CALML6, OR8G5, OR6A2, OR10G3, OR8B8, OR4K1",0.598599459218456,0.171984935776023,FALSE +"H1648","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.22828,-0.853,0.612,14026,0.88,"ATIC, DHFR, FTCD, TYMS, MTHFD2, MTR",0.213248577854439,0.0555173278498314,FALSE +"H1648","Input","KEGG_OOCYTE_MEIOSIS",-0.31904,-1.19,0.207,16772,0.78,"CPEB1, MAD2L2, CDC23, CALM1, PRKACA, SMC3, YWHAE, ADCY9, FBXO43, PRKACB, ITPR2, RPS6KA2, RPS6KA1, SMC1A, SKP1, PPP2R1A, RBX1, CALM3, SGO1, ANAPC13, PPP3CB, PPP2R5C, CDC25C, PPP2R5D, CDC16, PPP3R1, ANAPC10",0.684029654543082,0.10790539730952,FALSE +"H1648","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.49486,1.47,0.0576,6273,0.543,"MANBA, ENGASE, MAN2C1, FUCA2, HEXA, MAN2B1, MAN2B2, FUCA1, NEU1",1.23957751657679,0.265200170411153,FALSE +"H1648","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.23704,-0.845,0.626,18279,0.874,"NDUFA8, NDUFA7, NDUFA4, NDUFS4, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, ATP5ME, COX6B1, NDUFB2, ATP6V1E1, SDHC, ATP5MC2, NDUFS5",0.20342566678957,0.058488567365597,FALSE +"H1648","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.51195,1.53,0.0378,3145,0.458,"ST6GALNAC1, GCNT3, B4GALT5, GALNT7, GALNT5, GALNT12, GALNT10, GALNT3, GALNT6, GALNT18, GALNT14",1.42250820016277,0.339134521996131,FALSE +"H1648","Input","KEGG_P53_SIGNALING_PATHWAY",0.24741,0.736,0.854,6303,1,"ATR, GADD45A, SERPINB5, CD82, PERP, TP53I3, GADD45B, PMAIP1, SFN, EI24, RPRM, THBS1, CCND3, CYCS, TNFRSF10B, GADD45G, CDK6, IGFBP3, STEAP3, CCND1, BID, TP73, PIDD1, CHEK1, TSC2, CDKN1A, FAS",0.068542129310995,0,FALSE +"H1648","Input","KEGG_PANCREATIC_CANCER",0.29184,0.89,0.619,5629,1,"IKBKB, E2F1, SMAD3, EGF, VEGFC, BRAF, PIK3CB, MAPK9, RAD51, RAC2, TGFA, MAP2K1, MAPK10, BAD, TGFB3, NFKB1, PIK3CA, RALB, TGFBR2, IKBKG, RALGDS, RAC1, RELA, TGFB2, CDK6, EGFR, BRCA2, RAF1, PLD1, BCL2L1, TGFB1, CCND1, ERBB2",0.208309350979882,0,FALSE +"H1648","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.22684,0.68,0.913,5025,1,"PPCDC, COASY, PANK4, PANK3, PANK2",0.039529222465701,0,FALSE +"H1648","Input","KEGG_PARKINSONS_DISEASE",-0.26648,-0.963,0.477,18279,0.801,"NDUFA8, PINK1, NDUFA7, NDUFA4, NDUFS4, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, APAF1, COX6B1, NDUFB2, SDHC, PARK7, ATP5MC2, NDUFS5",0.321481620959886,0.0963674839157623,FALSE +"H1648","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.31553,-1.14,0.221,16110,0.593,"TUBA3D, ROCK1, YWHAQ, TUBB4A, CD14, ACTB, TUBA1B, ARHGEF2, TUBA8, RHOA, TUBB2A, ABL1, TLR4, TUBB3, FYN, TUBB, ARPC5, TUBA1A, CDC42",0.655607726314889,0.226945306635737,FALSE +"H1648","Input","KEGG_PATHWAYS_IN_CANCER",0.28487,0.85,0.661,3822,1,"MMP9, WNT9A, NFKBIA, DVL1, BIRC3, FGF17, IKBKB, TRAF4, DVL3, NFKB2, MET, FGFR3, E2F1, BCR, CXCL8, LAMC2, SMAD3, LAMA3, WNT7A, ITGA2, PLCG2, FGF11, FGF13, LAMB3, MMP1, PML, CDH1, EGLN3, EGF, VEGFC, WNT10A, JUP, BRAF, PIK3CB, MAPK9, CSF2RA, FOXO1, RUNX1, RAD51, RAC2, TRAF1, IL6, BMP2, CBLC, TGFA, PAX8, MAP2K1, TRAF2, VHL, LAMA2, FZD5, IGF1R, MAPK10, HDAC2, MECOM, PDGFB, BAD, ITGAV, PDGFA, PTK2, TGFB3, NFKB1, CSF1R, FZD6, LAMA5, RXRA, PIK3CA, MYC, MTOR, ELOC, TFG, RALB, TGFBR2, WNT3, FGFR2",0.17979854051436,0,FALSE +"H1648","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.26823,0.805,0.751,2843,1,"UGDH, RPEL1, GUSB",0.124360062995832,0,FALSE +"H1648","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.50757,1.53,0.038,5444,0.458,"G6PD, PGD, TKT, TALDO1, RPEL1, PFKL, FBP2, ALDOC, DERA, GPI, ALDOA, PGM2, PFKP",1.42021640338319,0.339134521996131,FALSE +"H1648","Input","KEGG_PEROXISOME",0.23246,0.7,0.895,5121,1,"XDH, SOD2, ACSL5, PRDX5, PEX2, SLC27A2, PEX5, PRDX1, DDO, ACAA1, MVK, PAOX, ABCD1, GSTK1, EPHX2, PEX3, MLYCD, EHHADH, AGPS, DHRS4, SOD1, PEX7, PEX16, NUDT19, ACOT8, ACOX1",0.048176964684088,0,FALSE +"H1648","Input","KEGG_PHENYLALANINE_METABOLISM",0.55315,1.65,0.0232,4365,0.771,"IL4I1, ALDH3A1, AOC2, ALDH1A3, ALDH3B2, MAOA, AOC3",1.6345120151091,0.112945621949043,FALSE +"H1648","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25378,0.755,0.822,3949,1,"INPP4A, PLCG2, PIK3CB, INPP4B, CALML6, PLCB3, DGKQ, DGKA, SYNJ2, PIK3C2B, CALML5, DGKG, DGKE, IPPK, PIK3C2G, PIK3CA, CDS1, ITPR3, OCRL",0.0851281824599496,0,FALSE +"H1648","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.34428,1.03,0.396,3373,0.875,"CP, EARS2, FTH1, GUSB, ALAS1, HMOX2",0.402304814074488,0.0579919469776868,FALSE +"H1648","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.18465,0.555,0.987,5588,1,"FABP6, MMP1, ACSL5, SLC27A4, ME1, SLC27A2, ACAA1, RXRA, CPT2, UBC, CYP27A1, EHHADH, ANGPTL4, CPT1C, ACOX1, CPT1A, ACSL1, SLC27A1, PPARG",0.00568284733036327,0,FALSE +"H1648","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.28189,0.849,0.718,4036,1,"CH25H, CYP7B1, AKR1D1, CYP27A1",0.1438755557577,0,FALSE +"H1648","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.38015,1.13,0.272,5251,0.703,"CD40, CIITA, ADA, TAP2, LCK, BLNK, IKBKG, JAK3, RAG2, UNG, TAP1",0.565431095965801,0.153044674980176,FALSE +"H1648","Input","KEGG_PRION_DISEASES",0.30397,0.926,0.578,2350,1,"CCL5, C9, IL1A, IL6, MAP2K1",0.238072161579471,0,FALSE +"H1648","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28281,-1.02,0.415,16258,0.753,"CDK1, PDE3A, ARAF, CPEB1, MAD2L2, CDC23, CDC25B, PRKACA, ADCY9, PRKACB, RPS6KA2, RPS6KA1, PDE3B, PIK3R1, AKT3, MAPK14, GNAI1, ANAPC13, CDC25C, CDC16, MAPK8, ANAPC10",0.381951903287907,0.123205023799299,FALSE +"H1648","Input","KEGG_PROPANOATE_METABOLISM",-0.28276,-1.06,0.344,14863,0.718,"ABAT, PCCA, SUCLA2, SUCLG1, ACSS1, LDHC, ACACB, HIBCH, ACADM, ALDH1B1, ALDH9A1",0.46344155742847,0.1438755557577,FALSE +"H1648","Input","KEGG_PROSTATE_CANCER",0.23981,0.722,0.875,5702,1,"NFKBIA, IKBKB, E2F1, EGF, BRAF, PIK3CB, FOXO1, TGFA, MAP2K1, IGF1R, PDGFB, BAD, PDGFA, NFKB1, CREB3, PIK3CA, MTOR, FGFR2, IKBKG, RELA, CREB5, EGFR, GSTP1, RAF1, TCF7, CCND1, ERBB2, MAP2K2",0.0579919469776868,0,FALSE +"H1648","Input","KEGG_PROTEASOME",0.27494,0.827,0.717,3211,1,"PSME4, PSME2, PSMB11, PSME1, PSMD11, PSMF1, PSMA5, PSMD2, PSMB5, PSMB10, PSMA6",0.1444808443322,0,FALSE +"H1648","Input","KEGG_PROTEIN_EXPORT",0.271,0.811,0.745,4969,1,"OXA1L, SRPRA, SEC63, SRP54, SRPRB, SEC11A, SEC62, SRP68, SEC61A1",0.127843727251707,0,FALSE +"H1648","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.16518,0.496,0.995,5399,0.996,"SLC25A10, GLUD1, ATP1B3, GLS2, ATP1A3, ATP1B1",0.00217691925427455,0.00174066157630127,FALSE +"H1648","Input","KEGG_PURINE_METABOLISM",-0.19398,-0.667,0.908,16712,0.932,"POLR2D, NME7, NPR2, RRM2B, PDE1C, PDE7B, POLA1, PDE6B, PDE6G, POLR2G, PAPSS1, ADSL, ADCY9, PDE10A, PDE8B, PDE6D, APRT, PRUNE1, AK5, PDE3B, PDE4B, PRIM2, AK7, ENPP1, PAPSS2, NT5M, DCK, POLR3GL, DGUOK, POLR1E",0.0419141514789149,0.0305840876460186,FALSE +"H1648","Input","KEGG_PYRIMIDINE_METABOLISM",0.21269,0.644,0.951,5377,1,"ENTPD3, POLR2H, UMPS, CMPK2, TXNRD1, POLR1B, PNP, UPP1, NME6, NT5C1B, POLD4, ENTPD4, UCKL1, PNPT1, DUT, NT5C2, TYMP, CDA, POLE2, POLR1C, NT5E, CAD, CMPK1, POLA2, NT5C, POLE, ENTPD5, NME5",0.0218194830625861,0,FALSE +"H1648","Input","KEGG_PYRUVATE_METABOLISM",-0.23207,-0.841,0.705,18284,0.835,"MDH1, ALDH1B1, ALDH9A1, GRHPR",0.151810883008601,0.0783135245163979,FALSE +"H1648","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.25971,0.782,0.794,3219,1,"ITGAM, FGF17, PFN4, DIAPH1, ITGB6, ARHGEF4, FGFR3, TMSB4Y, ITGA2, FGF11, FGF13, ITGB2, PAK6, EGF, BRAF, PIK3CB, BAIAP2, ITGB4, ITGB8, SSH3, MYH14, PAK2, RAC2, CHRM3, SSH1, MAP2K1, VAV1, FGD3, EZR, PAK1, ITGAX, PDGFB, ITGAV, TIAM1, LIMK2, PDGFA, PTK2, CSK, GIT1",0.100179497572904,0,FALSE +"H1648","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.24812,0.74,0.85,1482,1,"ULK1, ATG5, PIK3R4, BECN1",0.0705810742857073,0,FALSE +"H1648","Input","KEGG_RENAL_CELL_CARCINOMA",0.22262,0.671,0.926,5045,1,"MET, PAK6, EGLN3, VEGFC, BRAF, PIK3CB, PAK2, TGFA, MAP2K1, VHL, PAK1, PDGFB, TGFB3, PIK3CA, ELOC, HIF1A, RAC1, TGFB2, ETS1, RAF1",0.0333890133180656,0,FALSE +"H1648","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.25357,0.76,0.826,5920,1,"ACE, CTSA, REN, THOP1, ACE2",0.0830199526796178,0,FALSE +"H1648","Input","KEGG_RETINOL_METABOLISM",0.46555,1.4,0.0891,5135,0.474,"RDH16, ADH7, CYP1A1, DHRS9, DGAT1, RDH10, CYP26A1, CYP2C18, DHRS3, DGAT2, ALDH1A2, CYP26B1, LRAT, DHRS4, BCO1, ADH1A, DHRS4L2, ALDH1A1, RDH11",1.05012229596313,0.324221658325915,FALSE +"H1648","Input","KEGG_RIBOFLAVIN_METABOLISM",0.24282,0.72,0.882,5743,1,"MTMR1, ACP6, ACP4, ACP5, ACP1, FLAD1",0.0545314148681803,0,FALSE +"H1648","Input","KEGG_RIBOSOME",-0.51374,-1.8,0,16296,0.3,"RPL9, RPL26, RPL24, RPS4X, RPL10A, RPL3, RPS24, RPS18, RPS13, RPS15, RPL7A, RPL34, UBA52, RPL21, RPL13A, RPS23, RPL27A, RPL6, RPL29, RPL5, RPL11, RPSA, RPL37A, RPL18, RPL35, RPS19, RPS16, RSL24D1, RPS9, RPS5, RPS11, RPS6, RPS27L, RPS10, RPS15A, RPS27, RPL17",Inf,0.522878745280338,FALSE +"H1648","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.46961,1.41,0.0796,3125,0.494,"CXCL10, IFNB1, NFKBIA, DDX58, IKBKE, IKBKB, CXCL8, ATG5, DDX3Y, TRADD, ISG15, DHX58, IRF7, MAPK9, MAPK13, IRF3, IFIH1, TRAF2, MAPK10, TNF, NFKB1",1.09908693226233,0.306273051076353,FALSE +"H1648","Input","KEGG_RNA_DEGRADATION",-0.35043,-1.31,0.101,17144,0.677,"PAPOLG, DCP2, PAPOLA, EXOSC8, MPHOSPH6, XRN2, LSM3, LSM7, TTC37, LSM2, ENO1, EXOSC3, C1D, ZCCHC7",0.995678626217357,0.169411331314856,FALSE +"H1648","Input","KEGG_RNA_POLYMERASE",-0.25521,-0.926,0.528,14661,0.808,"POLR2C, POLR2L, POLR2J3, POLR2I, POLR2F, POLR2D, POLR2G, POLR3GL, POLR1E",0.277366077466188,0.0925886392254138,FALSE +"H1648","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.45765,1.38,0.104,4199,0.501,"LCMT1, AHCY, GGT6, GGT1, TRMT11, GGT7, AHCYL1, HEMK1, MAT2B",0.98296666070122,0.300162274132754,FALSE +"H1648","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.30031,0.895,0.623,3622,1,"NFKBIA, BIRC3, IKBKB, TRAF4, E2F1, LAMC2, LAMA3, ITGA2, LAMB3, PIK3CB, TRAF1, TRAF2, LAMA2, ITGAV, PTK2, NFKB1, LAMA5, RXRA, PIK3CA, MYC",0.20551195334083,0,FALSE +"H1648","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.25951,-0.905,0.537,17365,0.805,"USE1, STX8, SNAP25, VAMP5, STX2, SEC22B, VAMP3, STX12",0.270025714300444,0.0942041196321315,FALSE +"H1648","Input","KEGG_SPHINGOLIPID_METABOLISM",0.32506,0.982,0.459,3712,0.946,"SMPD2, GLA, SGPP2, ACER3, DEGS2, PLPP3, PLPP2, SPHK1, UGT8, SGMS2",0.338187314462739,0.0241088635982073,FALSE +"H1648","Input","KEGG_SPLICEOSOME",0.24679,0.737,0.853,1835,1,"LSM8, SRSF6, CTNNBL1, PRPF40B, SART1, SRSF5, THOC3, U2SURP, AQR, RBM22, ACIN1, PRPF38B, NCBP2, TCERG1, TRA2B, RBM25, ZMAT2, PRPF38A, SRSF2, ISY1",0.069050968832477,0,FALSE +"H1648","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.20729,0.629,0.963,3831,1,"UGDH, PYGL, GANC, GUSB, UXS1, GAA, GPI",0.0163737128754655,0,FALSE +"H1648","Input","KEGG_STEROID_BIOSYNTHESIS",-0.23238,-0.84,0.646,14250,0.814,"MSMO1, HSD17B7, SOAT1, CYP27B1, LSS, CYP51A1",0.189767482004916,0.0893755951107988,FALSE +"H1648","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.47261,1.43,0.0603,4006,0.549,"AKR1C2, CYP1A1, AKR1C3, HSD17B3, AKR1C1, SRD5A1, CYP7B1, CYP1B1, AKR1D1, SRD5A3, HSD11B1, HSD11B2, HSD17B8, SULT2B1",1.21968268785985,0.260427655549908,FALSE +"H1648","Input","KEGG_SULFUR_METABOLISM",0.4448,1.34,0.0918,4113,0.559,"SULT1A4, SULT1A1, CHST11, SULT1A2, SULT2B1, SUOX",1.03715731879876,0.252588192113577,FALSE +"H1648","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.22043,0.666,0.936,2957,1,"C9, CD40, C3, TNF",0.0287241512618947,0,FALSE +"H1648","Input","KEGG_TASTE_TRANSDUCTION",0.39248,1.18,0.215,5194,0.702,"SCNN1G, SCNN1B, TAS1R3, TAS2R31, SCNN1A, ADCY4, ADCY6, ITPR3, GNB1, TAS2R20, TAS2R4, TAS2R5, GNG3, TAS2R13, TAS2R19, TAS2R10",0.667561540084395,0.153662887870195,FALSE +"H1648","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.63202,1.9,0.00342,3251,0.639,"GGT6, GGT1, GAD1, GGT7",2.46597389394387,0.1944991418416,FALSE +"H1648","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.61874,-2.32,0,17922,0.0687,"HMGCR, IDI1, DHDDS, FDPS, GGPS1, PMVK",Inf,1.16304326294045,TRUE +"H1648","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.28043,-0.965,0.444,16153,0.827,"ROCK1, SMAD5, BMP8A, THBS2, RBL2, BMP8B, NOG, ID4, BMPR1A, CHRD, BMP6, ACVR2A, DCN, RHOA, SMAD9, SKP1, PPP2R1A, CDKN2B, ZFYVE16, RBX1, TFDP1, TGFBR1, BMPR2, LTBP1, SMAD2",0.35261702988538,0.0824944904474534,FALSE +"H1648","Input","KEGG_THYROID_CANCER",0.25693,0.77,0.818,5702,1,"CDH1, BRAF, PAX8, MAP2K1, RXRA, MYC, TFG, TCF7, PPARG, CCND1, CCDC6, MAP2K2",0.087246696328677,0,FALSE +"H1648","Input","KEGG_TIGHT_JUNCTION",0.33873,1.02,0.392,2982,0.88,"CLDN18, SRC, CLDN9, CLDN10, CLDN8, CGN, PRKCH, CLDN20, HCLS1, PPP2R2C, TJP3, CLDN7, CLDN3, AFDN, MYH14, CLDN23, EPB41L1, CRB3, CLDN4, CLDN1, OCLN, TJP1, MYH7B, YBX3, LLGL2, F11R, PPP2R2A, PRKCZ",0.406713932979543,0.0555173278498314,FALSE +"H1648","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.50914,1.55,0.0396,3623,0.534,"CXCL10, IFNB1, CXCL9, CXCL11, CCL5, NFKBIA, IRF5, TLR6, IKBKE, TLR1, TLR2, IKBKB, CXCL8, CD40, TAB2, IRF7, PIK3CB, MAPK9, MAPK13, CCL3, MAP3K8, IL6, TICAM1, IRF3, TLR5, MAP2K1, IRAK1, MAPK10, TNF, MYD88, NFKB1, TLR3, PIK3CA, IFNAR2",1.40230481407449,0.272458742971444,FALSE +"H1648","Input","KEGG_TRYPTOPHAN_METABOLISM",0.3607,1.08,0.338,517,0.772,"KYNU, IL4I1, CYP1A1, IDO1, KMO",0.471083299722345,0.112382699664264,FALSE +"H1648","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29189,0.868,0.659,5887,1,"IKBKB, PIK3CB, MAPK9, MAPK10, TNF, PRKCZ, PKM, PIK3CA, MTOR, SOCS2, INSR, IRS1, HK2, PRKCD, SOCS1, HK1, SOCS3, PRKCE",0.18111458540599,0,FALSE +"H1648","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.25809,0.767,0.826,2957,1,"IL1A, GAD1, TNF",0.0830199526796178,0,FALSE +"H1648","Input","KEGG_TYROSINE_METABOLISM",0.44025,1.33,0.116,4885,0.565,"LCMT1, ADH7, IL4I1, ALDH3A1, AOC2, ALDH1A3, TRMT11, ALDH3B2, HEMK1, MAOA, AOC3, FAH, ADH1A",0.935542010773082,0.247951552180562,FALSE +"H1648","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.3545,1.06,0.378,4757,0.821,"NFKBIA, CSF2, CARD11, IKBKB, NCK1, DLG1, NFATC4, PAK6, RASGRP1, NFKBIE, PIK3CB, MAPK9, MAPK13, PAK2, MAP3K8, PTPN6, CHP2, CBLC, MAP2K1, VAV1, PAK1, MAP3K14, TNF, NFKB1, TEC, LCK, PIK3CA, BCL10, IKBKG, LAT, NFATC2, VAV3, RELA, NFAT5, MAPK12",0.422508200162775,0.0856568428805592,FALSE +"H1648","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.19754,0.594,0.975,6114,1,"ITCH, BIRC3, UBE2J2, SMURF1, UBR5, PML, FBXO2, SYVN1, UBE2G2, UBE3C, CBLC, FBXW11, VHL, ANAPC7, UBE2L6, UBE2Z, UBE2K, ANAPC5, BRCA1, UBE2H, RNF7, BIRC6, HERC2, ANAPC4, ELOC, WWP1, UBA7, UBE2W, UBE2O, FZR1, ANAPC2, UBE4A, DDB1, UBE3B, SOCS1, UBA6, MAP3K1, ANAPC1, CDC34, HERC1, SOCS3, RHOBTB2, KEAP1, UBE3A, KLHL13, PIAS1, UBE2C, UBE2A, XIAP",0.0109953843014632,0,FALSE +"H1648","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.48196,-1.79,0.0242,14636,0.234,"BCAT2, VARS2, IARS2, PDHB",1.61618463401957,0.630784142589857,TRUE +"H1648","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.26043,-0.941,0.511,14302,0.798,"HMGCS2, HADHB, BCAT2, ACADSB, ABAT, OXCT1, PCCA, HMGCL, HSD17B10, BCKDHB, HIBADH, AOX1, HADH, HIBCH, ACADM, ALDH1B1, ACAA2, ALDH9A1",0.291579099865287,0.0979971086492706,FALSE +"H1648","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.17472,0.528,0.994,3255,0.999,"PLA2G4E, KCNMB3, PRKCH, ADRA1B, BRAF, CALML6, ADCY4, PLA2G4B, PLCB3, PLA2G10, MAP2K1, ADORA2A, ADCY6, CACNA1F, ADCY3, CALML5",0.00261361560268669,0.000434511774017692,FALSE +"H1648","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.3318,-1.17,0.268,15891,0.632,"AVPR2, DCTN4, DYNC1LI1, RAB5B, PRKACA, DCTN2, ADCY9, PRKACB, CREB3L1, ARHGDIA, DYNLL1, CREB3L2, DCTN6, DYNC1I2, DCTN1",0.571865205971211,0.199282921717615,FALSE +"H1648","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.31218,0.931,0.553,5910,1,"SRC, PLA2G4E, PLCG2, NFATC4, PIK3CB, MAPK13, RAC2, PLA2G4B, CHP2, PLA2G10, MAP2K1, NOS3, MAPKAPK3, BAD, PTK2, SPHK1, PIK3CA, PXN, PLA2G12A, NFATC2, PLA2G2F, RAC1, NFAT5, MAPK12, RAF1, PTGS2, CHP1, MAPK11, MAP2K2, SHC2, PLA2G6",0.257274868695302,0,FALSE +"H1648","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.36553,1.1,0.306,4492,0.739,"ATP6V0D2, ATP6V1C2, KCNQ1, ERO1A, PLCG2, TCIRG1, ATP6V0E1, TJP1, ATP6V0A2, ATP6V0B, ATP6V1H, ADCY3, ATP6V0E2, SLC12A2, ATP6V1C1, ATP6V1A, TJP2",0.51427857351842,0.131355561605174,FALSE +"H1648","Input","KEGG_VIRAL_MYOCARDITIS",0.20176,0.598,0.968,4621,1,"EIF4G1, CD40, ITGB2, MYH14, RAC2, MYH7B, LAMA2, MYH11, CXADR, CYCS, CAV1, RAC1",0.0141246426916063,0,FALSE +"H1648","Input","KEGG_WNT_SIGNALING_PATHWAY",0.25713,0.774,0.824,4389,1,"MMP7, TBL1Y, WNT9A, DVL1, DVL3, CHD8, CSNK1A1, SENP2, PORCN, TBL1XR1, SMAD3, WNT7A, NKD2, NFATC4, WNT10A, MAPK9, CTNNBIP1, RAC2, CHP2, PLCB3, FBXW11, FZD5, RUVBL1, MAPK10, CSNK1E, FRAT2, SFRP5, FZD6, PSEN1, CSNK1A1L, MYC, WNT3, VANGL1, CCND3, VANGL2, LRP5, WNT7B, NFATC2",0.0840727883028842,0,FALSE +"H2126","Input","KEGG_ABC_TRANSPORTERS",0.36567,1.08,0.328,3789,0.95,"ABCG2, ABCG1, ABCC2, ABCC3, ABCD1, ABCB8, ABCD4, ABCB7, ABCA12, ABCB6",0.484126156288321,0.0222763947111523,FALSE +"H2126","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.22193,-0.792,0.79,15187,0.873,"PIK3CD, MAP2K1, PPARD, CEBPA, EIF4EBP1, CCNA1, LEF1, PIK3R1, RAF1, PIM1, PIM2, TCF7, BAD, HRAS, PML, NRAS, AKT3",0.102372908709559,0.0589857562944303,FALSE +"H2126","Input","KEGG_ADHERENS_JUNCTION",-0.23621,-0.854,0.654,17317,0.825,"SNAI2, VCL, CDC42, RHOA, TCF7, ACTN1, ACTG1, CSNK2B, FER, NECTIN3, ACTB, FYN, WASF1",0.184422251675733,0.0835460514500749,FALSE +"H2126","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.42392,1.24,0.161,4364,0.769,"PRKAB1, IRS2, CPT1B, PRKAG1, TRAF2, STAT3, ADIPOR1, PRKAA2, ACSL1, PPARA, ACSL3, IKBKB, RELA, CAMKK2, RXRA, ACACB, TRADD, AKT1, PRKAB2, IKBKG, PRKAA1, CPT1C, TNFRSF1B, MTOR, TNFRSF1A",0.79317412396815,0.114073660198569,FALSE +"H2126","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.37403,1.09,0.313,4731,0.932,"AGXT, GPT, GLUL, GFPT1, CPS1, ALDH5A1, CAD, GLS2, ALDH4A1",0.504455662453552,0.0305840876460186,FALSE +"H2126","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.30824,0.914,0.592,4356,1,"IRS2, INS, SCNN1A, FXYD4, PIK3R3, ATP1B1, MAPK3, PRKCG, KCNJ1, MAPK1",0.22767829327708,0,FALSE +"H2126","Input","KEGG_ALLOGRAFT_REJECTION",-0.32815,-1.15,0.221,10722,0.638,"CD28, CD40LG, IL2, FASLG, IL12B, CD80, IL4, IL10, PRF1, CD86, TNF, GZMB, FAS, IL12A",0.655607726314889,0.195179321278838,FALSE +"H2126","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.52753,1.57,0.0325,4629,0.481,"PLA2G6, PLA2G12A, PLA2G10, ACOX3, PLA2G2D, PLA2G2C, PLA2G4A, PLA2G4B",1.48811663902113,0.317854923626168,FALSE +"H2126","Input","KEGG_ALZHEIMERS_DISEASE",0.18914,0.553,0.989,4587,1,"CASP9, ATP2A3, UQCR11, GRIN2D, EIF2AK3, GRIN1, CALML6, ITPR1, CACNA1D, NDUFV2, APH1A, NDUFA3, PSEN1, ERN1, APAF1, NDUFV1, IDE, COX6A1, NDUFA10, ATP5MC2, MAPK3, NDUFB1, ADAM10, NDUFA5, PLCB1, SDHA, UQCRHL, PSENEN, BID, MAPK1, TNFRSF1A, COX6A2, CACNA1F, GNAQ, SDHD",0.0048037084028206,0,FALSE +"H2126","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.29099,-1.02,0.375,16444,0.684,"WARS2, FARSB, LARS2, CARS2, RARS2, YARS2, PSTK",0.425968732272281,0.164943898279884,FALSE +"H2126","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.58332,1.71,0.0171,5813,0.723,"NANS, GMPPA, HK2, FPGT, GNPDA2, UGDH, GNPNAT1, GFPT1, GALK2, NANP, GMDS, PGM1, GNE, NPL, GMPPB, PGM3, PMM2, MPI, PGM2, CHIT1, HEXB, UGP2, GALT, GALE",1.76700388960785,0.140861702705469,FALSE +"H2126","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.21727,0.624,0.949,4364,1,"CASP9, GRIN2D, GRIN1, SLC1A2, MAP3K5, CCS, APAF1, BAX, MAPK13, DERL1, TNFRSF1B, BID, TNFRSF1A",0.0227337875727074,0,FALSE +"H2126","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.30656,0.911,0.594,4038,1,"CTSL, HSPA1L, CD4, LGMN, NFYC, TAPBP, IFI30, HSPA1A, CREB1, HSPA1B, HSPA2, KLRC3, PDIA3",0.226213555018806,0,FALSE +"H2126","Input","KEGG_APOPTOSIS",0.25302,0.74,0.865,4364,1,"CASP9, IRAK4, ATM, TRAF2, XIAP, IKBKB, AIFM1, RELA, CSF2RB, TRADD, PIK3R3, APAF1, BAX, AKT1, BIRC3, MYD88, IL1R1, IKBKG, BIRC2, BID, TNFRSF1A",0.0629838925351858,0,FALSE +"H2126","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.43071,1.27,0.156,3980,0.743,"CYP4A22, PTGES, PLA2G6, ALOX15B, PLA2G12A, CYP4F3, CYP2J2, PLA2G10, PTGES2, LTA4H, PTGDS, ALOX5, PLA2G2D, PTGS1, GPX2, EPHX2, ALOX12B, PLA2G2C, LTC4S, PLA2G4A, GPX3",0.806875401645538,0.129011186239425,FALSE +"H2126","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.2584,0.759,0.81,6291,1,"GLUL, SAT1, PYCR1, ALDH18A1, GATM, CKMT1A, CKMT1B, ALDH2, CPS1, ALDH3A2, P4HA3, ARG1, GLS2, AGMAT, MAOA, ALDH4A1, GAMT, ASS1, P4HA2, ASL, PYCR3, ODC1",0.0915149811213502,0,FALSE +"H2126","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.18921,0.545,0.985,4525,1,"CACNB2, CACNG1, CACNA1D, ITGB6, ITGB5, ITGA1, CACNG6, ITGA2B, JUP, DMD, ITGB1, DSP, CACNG8, CACNG4, CACNA1F",0.00656376950238827,0,FALSE +"H2126","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.25981,0.764,0.831,3745,1,"UGDH, ALDH2, ALDH3A2",0.080398976215889,0,FALSE +"H2126","Input","KEGG_ASTHMA",0.25981,0.755,0.819,14150,1,"CD40, EPX, IL5, IL13, IL9, MS4A2, FCER1A, FCER1G, CD40LG, IL3, CCL11, PRG2, IL4, IL10, TNF, RNASE3",0.0867160982395816,0,FALSE +"H2126","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.27766,0.814,0.76,170,1,"CGA",0.119186407719209,0,FALSE +"H2126","Input","KEGG_AXON_GUIDANCE",0.21615,0.635,0.962,3790,1,"FES, RND1, SEMA4C, EFNA1, SRGAP1, EPHA1, SEMA3E, EFNA3, SEMA4B, NTN4, PLXNB2, PLXNA3, SEMA3B, PAK4, PAK6, EPHB6, EFNA4, RHOD, MAPK3, SRGAP3, EFNA5, ARHGEF12, ROCK1, ITGB1, SEMA4G",0.0168249279621871,0,FALSE +"H2126","Input","KEGG_BASAL_CELL_CARCINOMA",0.36601,1.07,0.345,1246,0.967,"WNT3A, FZD10, WNT4, WNT7B, WNT11",0.462180904926726,0.0145735259169983,FALSE +"H2126","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.3626,-1.3,0.134,17299,0.683,"GTF2H1, STON1, TAF9, GTF2E2, GTF2H3, TAF5, TAF7, GTF2B, TBPL1",0.872895201635192,0.165579296318467,FALSE +"H2126","Input","KEGG_BASE_EXCISION_REPAIR",0.27861,0.811,0.755,1281,1,"LIG3, SMUG1, NEIL1, MUTYH",0.122053048370812,0,FALSE +"H2126","Input","KEGG_BETA_ALANINE_METABOLISM",0.28488,0.843,0.696,3745,1,"AOC2, ACADM, AOC3, ALDH2, ALDH3A2",0.157390760389438,0,FALSE +"H2126","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.27539,0.801,0.757,2367,1,"ACOT4, ACOX3, ACOT1, ACOT2",0.120904120499927,0,FALSE +"H2126","Input","KEGG_BLADDER_CANCER",-0.31965,-1.19,0.2,15388,0.66,"MAP2K1, EGF, PGF, RASSF1, CXCL8, THBS1, CDKN1A, MMP1, RAF1, E2F2, E2F3, MMP2, TP53, CDKN2A, VEGFB, HRAS, NRAS, CDK4",0.698970004336019,0.180456064458131,FALSE +"H2126","Input","KEGG_BUTANOATE_METABOLISM",-0.27931,-0.949,0.442,16610,0.677,"PDHB, ACSM3, ALDH1B1, ECHS1, ACAT1, ALDH9A1, BDH2, OXCT1",0.354577730650908,0.169411331314856,FALSE +"H2126","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.23363,0.689,0.885,4005,1,"BLNK, VAV1, IKBKB, RELA, SOS2, CD72, PTPN6, PLCG2, PIK3R3, RASGRP3, AKT1, CD22, VAV2, MAPK3, CD19, IKBKG, SOS1",0.0530567293021746,0,FALSE +"H2126","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.32819,0.968,0.486,3057,1,"BDKRB2, CD38, ATP2A3, BDKRB1, CACNA1I, ADCY4, PHKA1, P2RX4, GRIN2D, RYR1, GRIN1, CALML6, ITPR1, ADRA1D, ATP2B1, SLC8A2, CACNA1D, PTAFR, P2RX2, ERBB2, GNA14, PHKA2, CAMK2G, LTB4R2, PLCG2, TACR3, TRHR, ERBB3, CACNA1A",0.313363730737707,0,FALSE +"H2126","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.27836,0.826,0.724,1492,1,"CACNB2, CACNG1, TNNI3, UQCR11, CACNA1D, SLC9A1",0.140261433802853,0,FALSE +"H2126","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.24197,0.716,0.87,3758,1,"CDH5, ITGB2, ICAM3, CD4, PTPRF, CNTN1, ICOSLG, CDH3, NRXN3, CLDN3, ITGAL, CLDN20, CLDN7, CDH1, CD40, F11R, CD22, CLDN4, PTPRM, OCLN, ITGB1",0.0604807473813815,0,FALSE +"H2126","Input","KEGG_CELL_CYCLE",-0.46269,-1.66,0.0484,16390,0.557,"GSK3B, MAD2L2, TTK, CCNA1, TFDP1, PTTG2, YWHAE, CCNE2, CDC20, MAD1L1, MCM5, CDKN1A, CDC25C, E2F2, MCM3, ANAPC13, TFDP2, E2F3, MCM2, RBL1, PRKDC, SKP1, PKMYT1, CCNH, MCM6, CDKN2B, TP53, CDK6, MAD2L1, CDKN2D, BUB1, CDKN2A, YWHAQ, CDC14A, GADD45A, CCNB2, CDKN1C, CDKN2C, PLK1, HDAC2, CDK1, CCNA2, CDC25A, MCM4, CDC7, ORC3, HDAC1, ORC6, BUB3, PTTG1, CDK4, CCNB1, SMC3, TGFB1",1.31515463835559,0.254144804826271,FALSE +"H2126","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.24171,0.709,0.893,4024,1,"CCL22, ADCY5, CCR7, CCL17, ADCY4, ARRB1, VAV1, JAK3, STAT3, CCR3, ARRB2, IKBKB, RELA, CXCL16, WASL, GRK2, SOS2, ADCY6, PIK3R3, STAT2, AKT1, CXCL3, VAV2, MAPK3, PREX1, STAT5B, CXCL2, PRKCD, ROCK1, IKBKG, CCL28, SOS1, TIAM1",0.0491485411114536,0,FALSE +"H2126","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.32338,-1.12,0.273,16866,0.571,"CDKN1A, PIK3R1, RAF1, E2F2, SHC2, E2F3, TP53, CDK6, CDKN2A, MECOM, BAD, HDAC2, HRAS, NRAS, AKT3, HDAC1, CDK4, TGFB1",0.563837352959244,0.243363891754152,FALSE +"H2126","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.57486,1.69,0.0161,5204,0.612,"CSNK1E, PER2, CSNK1D, NPAS2, CLOCK, CRY1, BHLHE40, BHLHE41",1.79317412396815,0.213248577854439,FALSE +"H2126","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.28756,0.841,0.705,4824,1,"SUCLG2, IDH3G, PC, IDH2, IDH3B, DLAT, SDHA, DLST, ACO2, SDHD, MDH2, PDHA1, IDH1",0.151810883008601,0,FALSE +"H2126","Input","KEGG_COLORECTAL_CANCER",-0.27994,-1.03,0.346,15119,0.689,"RAC1, PIK3CD, MSH6, MAP2K1, MLH1, SMAD3, TGFB3, GSK3B, LEF1, MAPK10, BIRC5, PIK3R1, RAF1, RHOA, TP53, BCL2, JUN, TCF7, BAD, AKT3, TGFB1",0.460923901207223,0.161780778092374,FALSE +"H2126","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.45314,1.33,0.0974,1849,0.789,"FGA, BDKRB2, FGG, FGB, BDKRB1, CD55, C8G, PLG, TFPI",1.01144104312138,0.10292299679058,FALSE +"H2126","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.259,0.758,0.85,1369,1,"LDHC, TAT, CTH, AHCYL1",0.0705810742857073,0,FALSE +"H2126","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.19403,0.579,0.979,4429,1,"CCL22, CCR7, CCL17, INHBB, EPO, TNFSF11, IFNL3, IL9R, TNFRSF18, IL13RA1, TGFBR1, CCR3, BMP7, CXCL16, CSF2RB, GH2, PDGFB, CD40, TNFRSF25, TNFSF13, TNFSF15, CLCF1, EPOR, CXCL3, LTBR, KITLG, VEGFC, CXCL2, OSMR, IL20RA, IL1R1, CCL28, TNFRSF1B, VEGFA, TNFRSF1A, VEGFD, IFNL2, TPO",0.00921730819686218,0,FALSE +"H2126","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.2581,0.764,0.826,4933,1,"RIPK3, IRF3, IKBKB, RELA, ADAR, POLR3F, POLR3GL, TBK1, IKBKG, MAVS, CCL5, NFKBIB",0.0830199526796178,0,FALSE +"H2126","Input","KEGG_DILATED_CARDIOMYOPATHY",0.273,0.806,0.757,2736,1,"ADCY5, CACNB2, CACNG1, TNNI3, ADCY4, CACNA1D, ITGB6, ITGB5, ITGA1, ADCY6, CACNG6, ITGA2B",0.120904120499927,0,FALSE +"H2126","Input","KEGG_DNA_REPLICATION",-0.6495,-2.36,0.0087,16205,0.0748,"POLE3, PCNA, RPA2, POLE, RFC1, MCM5, PRIM1, POLA2, POLA1, MCM3, RPA3, RNASEH2C, RFC5, MCM2, MCM6, RFC4, RFC2, FEN1, MCM4, PRIM2",2.06048074738138,1.12609840213554,TRUE +"H2126","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.43235,1.27,0.142,4847,0.743,"PIWIL2, ETS2, SPIRE2, NOTCH3, SOS2, MAPK3, SOS1, MAPK1, ETV7",0.847711655616944,0.129011186239425,FALSE +"H2126","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.42313,1.25,0.162,3429,0.759,"GSTA3, ALDH3B2, GSTK1, ALDH3B1, CYP2A7, CYP2A6, CYP2D6, GSTM5, GSTZ1, GSTA4, GSTO2, GSTM3, MGST1, FMO5, ALDH1A3",0.790484985457369,0.11975822410452,FALSE +"H2126","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.35672,1.05,0.367,1174,1,"CES1, TYMP, CYP2A7, GUSB, CYP2A6",0.435333935747911,0,FALSE +"H2126","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.24668,-0.852,0.664,14988,0.807,"COL4A4, GP1BB, ITGA7, ITGA9, COL11A1, ITGA11, RELN, COL5A3, COL6A3, THBS2, COL3A1, LAMA4, ITGAV, COL11A2, ITGB3, THBS1, COL1A2, COL4A6, SPP1, ITGA4, LAMA1, ITGB8, LAMA2, COL4A2, COL5A2, THBS4, SV2A, COL5A1, ITGA6, SDC2, FN1, TNC, COL6A2, HMMR, COL4A1",0.177831920631982,0.0931264652779296,FALSE +"H2126","Input","KEGG_ENDOCYTOSIS",0.30523,0.913,0.577,3795,1,"CHMP1B, HSPA1L, ARFGAP3, PLD1, ARRB1, CHMP2A, ARFGAP1, USP8, PLD2, RAB11B, STAM2, ARRB2, CBLC, CHMP5, VPS45, EPN3, PIP5K1B, SMURF1, IQSEC2, VPS36, GRK2, ARAP2, SH3GLB2, AP2A1, TFRC, IGF1R, VPS28, CHMP3, RAB11FIP4, RAB31, ERBB3, HSPA1A, WWP1, PSD4, RAB5B, FGFR3, VPS37C, ASAP2, HSPA1B, CHMP2B, HSPA2, ITCH, CHMP4B",0.238824186844269,0,FALSE +"H2126","Input","KEGG_ENDOMETRIAL_CANCER",-0.21223,-0.747,0.852,15187,0.934,"PIK3CD, FOXO3, MAP2K1, MLH1, EGF, GSK3B, ELK1, LEF1, PIK3R1, RAF1, TP53, TCF7, BAD, HRAS, NRAS, AKT3",0.0695604052332999,0.0296531237699066,FALSE +"H2126","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.19245,0.565,0.98,5904,1,"ATP6V1B1, ATP6V0A4, ATP6AP1, IKBKB, RELA, TCIRG1, PLCG2, MAPK13, F11R, ATP6V0B, ADAM10, IKBKG, ATP6V0E2, ATP6V1G1, MAPK11, CCL5, PAK1, ATP6V1F, ATP6V1E2, IGSF5, NFKBIA, ADAM17, EGFR",0.00877392430750515,0,FALSE +"H2126","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.18735,0.549,0.988,4693,1,"GAB1, CBLC, ERBB2, BTC, CAMK2G, SOS2, PAK4, PAK6, PLCG2, PIK3R3, ERBB3, AKT1, MAP2K7, MAPK3, STAT5B, SOS1, PRKCG, MTOR, MAPK1, NRG4, AREG",0.00524305541237188,0,FALSE +"H2126","Input","KEGG_ETHER_LIPID_METABOLISM",0.49491,1.45,0.0542,4713,0.632,"PLA2G6, PLD1, PAFAH2, PLD2, PLA2G12A, PLA2G10, PLPP3, PLA2G2D, PLA2G2C, PLA2G4A, PAFAH1B2, PLA2G4B, LPCAT1",1.26600071346161,0.199282921717615,FALSE +"H2126","Input","KEGG_FATTY_ACID_METABOLISM",0.3501,1.04,0.373,4233,1,"CYP4A22, CPT1B, ACADM, ACSL1, CPT2, ACSL3, ACOX3, ACADS, ALDH2, ALDH3A2, ACAA1, CPT1C, HADHB",0.428291168191312,0,FALSE +"H2126","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.27487,0.805,0.785,4709,1,"PLA2G6, VAV1, PLA2G12A, PLA2G10, SOS2, PLCG2, PLA2G2D, PIK3R3, MAPK13, AKT1, MAP2K7, PLA2G2C, VAV2, MAPK3, PRKCD, PLA2G4A, SOS1, MAPK1, PLA2G4B, VAV3, MAPK11",0.105130343254747,0,FALSE +"H2126","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.22207,0.657,0.941,4703,1,"PLA2G6, PLD1, VAV1, PLD2, PIP5K1B, PLPP3, WASL, ARPC1A, PLCG2, PIK3R3, AKT1, ARPC1B, VAV2, ASAP2, MAPK3, VASP, PRKCD, PLA2G4A, PRKCG, MYO10, MAPK1, PLA2G4F, WASF3, PLA2G4B, VAV3",0.0264103765727431,0,FALSE +"H2126","Input","KEGG_FOCAL_ADHESION",-0.27255,-0.974,0.403,14988,0.643,"COL4A4, ITGA7, ITGA9, RAC1, PIK3CD, COL11A1, CAV1, ACTN2, ITGA11, MAP2K1, RELN, EGF, COL5A3, SHC4, PGF, COL6A3, PDGFRA, THBS2, MYLK2, PRKCA, COL3A1, LAMA4, MYLPF, CCND2, SHC3, ITGAV, PAK3, MYL5, GSK3B, COL11A2, ITGB3, DOCK1, THBS1, PDGFRB, COL1A2, ELK1, COL4A6, SPP1, ITGA4, MAPK10, LAMA1, ITGB8, PIK3R1, RAF1, LAMA2, COL4A2, SHC2, VCL, FLNC, COL5A2, THBS4, CDC42, PARVA, COL5A1, RHOA, PPP1CC, MYL9, ITGA6, BCL2, JUN, MYLK, FN1, TNC, VEGFB, COL6A2, ACTN1, BAD, ACTG1, COL4A1, HRAS, PDGFC, AKT3, ACTB, FYN, FLNA",0.39469495385889,0.191789027075778,FALSE +"H2126","Input","KEGG_FOLATE_BIOSYNTHESIS",0.37341,1.1,0.313,3757,0.915,"PTS, GCH1, SPR, QDPR",0.504455662453552,0.0385789059335517,FALSE +"H2126","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.33426,0.969,0.483,3315,1,"GMPPA, FBP1, HK2, FPGT, PHPT1, GMDS, PFKFB2, GMPPB",0.316052869248488,0,FALSE +"H2126","Input","KEGG_GALACTOSE_METABOLISM",0.38366,1.13,0.266,5813,0.953,"HK2, B4GALT1, GAA, GALK2, PGM1, B4GALT2, GLA, MGAM, PGM2, GLB1, UGP2, GALT, G6PC2, GALE",0.575118363368933,0.0209070993616736,FALSE +"H2126","Input","KEGG_GAP_JUNCTION",-0.29855,-1.1,0.264,15131,0.588,"TUBA4A, DRD2, GNAI3, PLCB3, MAP2K1, EGF, PDGFRA, MAPK7, GUCY1A2, PRKCA, PRKG1, GUCY1A1, MAP3K2, PDGFRB, TUBB4A, ADCY1, RAF1, PRKACA, GUCY1B1, TUBB4B, TUBA1B, GJA1, TUBB2B, GNAI1, TUBA1A, HRAS, CDK1, NRAS, PDGFC, TUBB, ADCY7, TUBB6, GNAI2, TUBB2A",0.578396073130169,0.230622673923862,FALSE +"H2126","Input","KEGG_GLIOMA",-0.27635,-0.975,0.4,15187,0.685,"PIK3CD, MAP2K1, EGF, SHC4, PDGFRA, PRKCA, SHC3, PDGFRB, CDKN1A, PIK3R1, RAF1, E2F2, SHC2, E2F3, TP53, CDK6, CDKN2A, HRAS, CALM2, NRAS, AKT3, CDK4",0.397940008672038,0.164309428507574,FALSE +"H2126","Input","KEGG_GLUTATHIONE_METABOLISM",0.38098,1.14,0.271,3980,0.964,"GSTA3, GSTK1, TXNDC12, G6PD, GSTM5, GSTZ1, OPLAH, GSTA4, GSTO2, GSTM3, GCLC, MGST1, GPX2, IDH2, GSR, MGST2, GPX3",0.567030709125594,0.0159229660971692,FALSE +"H2126","Input","KEGG_GLYCEROLIPID_METABOLISM",0.26236,0.768,0.819,5940,1,"AKR1A1, DGAT1, PLPP3, TKFC, DGKE, MBOAT1, DGAT2, ALDH2, ALDH3A2, GLA, LCLAT1, GPAT4, DGKQ, AGPAT4, MGLL, GPAT2, PLPP2, AGK",0.0867160982395816,0,FALSE +"H2126","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40279,1.18,0.213,4713,0.94,"PISD, LPGAT1, PLA2G6, PLD1, CHKB, PLD2, PLA2G12A, CDS1, PLA2G10, PLPP3, PEMT, PLA2G2D, CRLS1, DGKE, MBOAT1, PLA2G2C, PLA2G4A, LCLAT1, GPAT4, DGKQ, PTDSS2, PLA2G4B, AGPAT4, LPCAT1",0.671620396561262,0.0268721464003014,FALSE +"H2126","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.395,1.16,0.246,5552,0.963,"AGXT, AOC2, CTH, AOC3, DMGDH, GATM, MAOA, AMT, SRR, GAMT, DLD, GCAT",0.609064892896621,0.0163737128754655,FALSE +"H2126","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.2415,0.708,0.876,5481,1,"ALDH3B2, ALDH3B1, LDHC, AKR1A1, FBP1, HK2, PGM1, GALM, ACSS2, PGAM2, ALDH2, ALDH1A3, ALDH3A2, DLAT, BPGM, PDHA1, PGM2, PGK2, LDHA, DLD, LDHAL6B",0.0574958938319193,0,FALSE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.27556,0.803,0.75,5075,1,"CSGALNACT1, XYLT1, B4GALT7, CHST11, CHST15, CHST12, XYLT2, CHSY1, CHPF",0.1249387366083,0,FALSE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.29535,0.867,0.674,2944,1,"XYLT1, HS6ST1, HS6ST2, HS6ST3, B4GALT7",0.17134010346468,0,FALSE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.50905,1.5,0.0537,2407,0.532,"B3GNT7, B4GALT4, ST3GAL1, B4GALT1, B3GNT2, CHST6",1.27002571430044,0.274088367704952,FALSE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.60147,1.77,0.00804,5672,0.761,"HGSNAT, NAGLU, HYAL1, IDUA, GUSB, HYAL4, GNS, HYAL2, GALNS, IDS, HEXB, GLB1, HPSE",2.09474395125155,0.118615343229427,FALSE +"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.23299,0.683,0.916,5605,1,"ST3GAL1, B3GALT4, SLC33A1, ST6GALNAC4, HEXB, GLB1",0.0381045263321496,0,FALSE +"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.45542,1.34,0.118,5491,0.791,"FUT2, ST3GAL1, NAGA, GBGT1, A4GALT, GLA, HEXB, FUT1",0.928117992693875,0.101823516502323,FALSE +"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.53373,1.56,0.0378,2364,0.423,"B4GALT4, ST3GAL4, FUT2, FUT3, B3GNT3, B4GALT1, ABO, B3GNT2",1.42250820016277,0.373659632624958,FALSE +"H2126","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.54041,1.58,0.031,4759,0.505,"PIGO, PIGT, PIGF, PIGU, DPM2, GPAA1, PIGL, PIGH, PIGZ, PIGV, PIGK, GPLD1, PIGS, PIGB, PIGP",1.50863830616573,0.296708621881339,FALSE +"H2126","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.24867,0.728,0.869,5325,1,"MTHFD2L, AFMID, ACO2, MTHFD2, MDH2, GRHPR",0.0609802235513335,0,FALSE +"H2126","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.35081,1.03,0.399,4746,1,"ADCY5, CGA, MAP3K4, ADCY4, PLA2G6, PLD1, CALML6, ITPR1, CACNA1D, PLD2, PLA2G12A, PLA2G10, CAMK2G, SOS2, ADCY6, ATF4, PLA2G2D, MAPK13, MAP2K7, PLA2G2C, MAPK3, PRKCD, PLA2G4A, SOS1, PLCB1, MAPK1, CACNA1F, GNAQ, PLA2G4B, MAPK11, LHB",0.399027104313252,0,FALSE +"H2126","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.49648,-1.79,0.0368,10721,0.482,"KIR2DL1, CD28, KIR3DL2, IL2, KLRC1, KIR3DL1, KIR2DL3, FASLG, CD80, IL6, PRF1, CD86, TNF, GZMB, IL1A, IL1B, FAS",1.43415218132648,0.31695296176115,FALSE +"H2126","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.37973,1.11,0.298,1742,0.94,"WNT3A, CSNK1E, WNT4, WNT7B, BMP6, WNT11, BMP7, BMP8B",0.525783735923745,0.0268721464003014,FALSE +"H2126","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.32319,0.953,0.52,5962,1,"CD38, CD14, EPO, CD4, IL9R, CD55, ITGA1, TFRC, ITGA2B, EPOR, CD22, KITLG, CD19, IL1R1, GP1BA, TPO, CD37, CD5, IL1R2, IL4R, CD59, DNTT, IL7, FCGR1A, ITGA3",0.283996656365201,0,FALSE +"H2126","Input","KEGG_HISTIDINE_METABOLISM",0.52547,1.56,0.036,636,0.423,"HAL, AMDHD1, ALDH3B2, ALDH3B1, BUD23",1.44369749923271,0.373659632624958,FALSE +"H2126","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.27595,0.801,0.769,7114,1,"RAD52, BLM, POLD4, MRE11, SEM1, XRCC3, NBN, TOP3B, BRCA2, EME1, RAD50, RAD54B, MUS81, XRCC2, POLD3, RAD51D",0.114073660198569,0,FALSE +"H2126","Input","KEGG_HUNTINGTONS_DISEASE",-0.28479,-1.01,0.365,16178,0.633,"NDUFB3, CLTB, DNALI1, DNAH1, SDHC, NDUFA8, COX6B2, UQCRQ, NDUFA2, DCTN4, VDAC2, NDUFB8, ATP5F1C, NDUFA9, NDUFAB1, SDHB, TFAM, POLR2D, AP2S1, COX4I1, TP53, BDNF, AP2M1, UQCRC1, NDUFB5, NDUFA1, CREB5, CLTA, HDAC2, ATP5MC3, ATP5PF, NDUFS3, COX8A, BBC3, ATP5PO, IFT57, HDAC1, NDUFS4, NDUFB6, TBPL1, ATP5F1A, HIP1, POLR2E, GPX1",0.437707135543525,0.198596289982645,FALSE +"H2126","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.28411,0.828,0.718,2736,1,"CACNB2, CACNG1, PRKAB1, TNNI3, PRKAG1, PRKAA2, CACNA1D, ITGB6, ITGB5, ITGA1, CACNG6, ITGA2B",0.1438755557577,0,FALSE +"H2126","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.24748,0.729,0.86,4850,1,"OCRL, ALDH6A1, INPP4A, PIP4K2C, PIP5K1B, ITPK1, PLCG2, PI4KB, INPP5B, INPPL1, INPP5K, IMPA2, PLCB1, PIK3C2A, IPMK",0.0655015487564323,0,FALSE +"H2126","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.35765,1.04,0.377,4207,1,"PRKAB1, IRS2, INS, PHKA1, PPP1R3B, PRKAG1, GYS1, CALML6, FBP1, HK2, PRKAA2, PTPRF, MKNK1, CBLC, PPP1R3D, IKBKB, SOCS2, TSC1, ACACB, PHKA2, SOS2, SREBF1, PPP1R3C, PIK3R3, PYGL, AKT1, RPTOR, FOXO1, FASN, ACACA, MAPK3, SOCS4, MKNK2, PRKAB2, PHKG1, PRKAA1, SOS1, INPP5K, MTOR",0.423658649794207,0,FALSE +"H2126","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.23361,-0.815,0.725,15219,0.869,"MAP3K14, CXCL12, CCL27, IL15, CXCR4, ITGA4, CCR10, MADCAM1, TGFB1",0.139661993429006,0.0609802235513335,FALSE +"H2126","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.27339,0.806,0.747,4429,1,"EPO, SPRY3, IFNL3, JAK1, JAK3, IL9R, IL13RA1, STAT3, PIAS3, STAM2, CBLC, SOCS2, CSF2RB, SOS2, GH2, PTPN6, PIK3R3, SOCS7, STAT2, TYK2, AKT1, CLCF1, EPOR, STAT5B, SOCS4, EP300, OSMR, IL20RA, SOS1, IFNL2, STAT6, TPO",0.126679398184601,0,FALSE +"H2126","Input","KEGG_LEISHMANIA_INFECTION",0.23567,0.691,0.89,3758,1,"NCF4, ITGB2, JAK1, IRAK4, RELA, PTPN6, MAPK13, TAB1, MAPK3, MYD88, ITGB1",0.0506099933550872,0,FALSE +"H2126","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.25033,0.731,0.843,5306,1,"CDH5, NCF4, ITGB2, VAV1, RAPGEF4, RAPGEF3, CLDN3, CTNND1, ITGAL, CLDN20, CLDN7, PLCG2, PIK3R3, TXK, MAPK13, ARHGAP35, F11R, VAV2, CLDN4, VASP, RASSF5, OCLN, ROCK1, ITGB1, SIPA1, PRKCG, CLDN9, VAV3, MAPK11, PXN, CTNNA1, AFDN, CLDN8, CYBB",0.0741724253752577,0,FALSE +"H2126","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.41231,-1.51,0.0544,17832,0.574,"ALDH1B1, ECHS1, ALDH9A1",1.26440110030182,0.241088107602027,FALSE +"H2126","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.45089,1.31,0.13,5251,0.789,"PLA2G6, PLA2G12A, CYP2J2, PLA2G10, PLA2G2D, PLA2G2C, PLA2G4A, CYP3A43, PLA2G4B, ALOX15, CYP3A7",0.886056647693163,0.10292299679058,FALSE +"H2126","Input","KEGG_LONG_TERM_DEPRESSION",0.28697,0.847,0.71,4629,1,"PLA2G6, RYR1, ITPR1, PLA2G12A, PLA2G10, PRKG2, IGF1R, GNAO1, PLA2G2D, CACNA1A, PLA2G2C, MAPK3, PPP2R1B, PLA2G4A, PRKCG, PLCB1, MAPK1, GNAQ, PLA2G4B",0.148741651280925,0,FALSE +"H2126","Input","KEGG_LONG_TERM_POTENTIATION",0.24903,0.729,0.861,4541,1,"GRIN2D, GRIN1, CALML6, ITPR1, RPS6KA2, RPS6KA6, RAPGEF3, CAMK2G, ATF4, MAPK3, EP300, PRKCG, PLCB1, MAPK1, GNAQ",0.0649968485463452,0,FALSE +"H2126","Input","KEGG_LYSINE_DEGRADATION",0.23752,0.691,0.896,3759,1,"SETDB1, SETD7, EHMT1, KMT5B, ASH1L, KMT5C, AASDH, ALDH2, ALDH3A2, AASDHPPT",0.0476919903378748,0,FALSE +"H2126","Input","KEGG_LYSOSOME",0.4666,1.38,0.0874,5816,0.733,"SLC11A1, HGSNAT, PPT1, GM2A, CTSL, NAGLU, ARSA, FUCA1, HYAL1, ATP6V0A4, IDUA, GUSB, SLC11A2, CLN3, ATP6AP1, LGMN, AP3S2, NAGA, CTSA, GGA1, AP4M1, AGA, GAA, GALC, LAMP1, GNPTG, ASAH1, SLC17A5, GNS, TCIRG1, CTSH, DNASE2, CD63, CTSF, LAPTM4A, MFSD8, CTSD, AP1M2, ARSG, AP1G1, ATP6V0B, MAN2B1, CLN5, GALNS, LIPA, LAMP3, GLA, SORT1, AP3M1, NPC1, AP3D1, IDS, GGA3, NAGPA, CD68, ACP2, PSAP, MANBA, HEXB, GBA, CTSC, GLB1, ABCA2, CTSS, LAMP2, AP3B1",1.0584885673656,0.134896025358872,FALSE +"H2126","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.26325,0.778,0.818,4631,1,"CACNB2, CACNG1, CACNA1I, CD14, MAP3K4, HSPA1L, PLA2G6, ARRB1, DUSP16, NR4A1, RPS6KA2, TGFBR1, TRAF2, CACNA1D, FGF12, MAP3K8, PLA2G12A, RPS6KA6, FGF19, DUSP8, ARRB2, MKNK1, IKBKB, RELA, MAPK8IP2, PLA2G10, GADD45B, DUSP4, SOS2, ATF4, MAP3K5, FGF11, PDGFB, CACNG6, PLA2G2D, RASGRP3, MAPK13, AKT1, TAOK1, CACNA1A, RPS6KA5, MAP4K3, HSPA1A, MAP2K7, TAB1, PLA2G2C, FGFR3, MAP3K11, MAPK3, HSPA1B, STK3, MKNK2, HSPA2, TAOK3, IL1R1, IKBKG, PLA2G4A, DUSP1, MAPKAPK2, SOS1, RRAS, PRKCG, MAPK1, TNFRSF1A, CACNG8, NLK, CACNG4, CACNA1F, PLA2G4B, GADD45G",0.087246696328677,0,FALSE +"H2126","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.31047,0.902,0.62,1738,1,"INS, BHLHA15, FOXA3",0.207608310501746,0,FALSE +"H2126","Input","KEGG_MELANOGENESIS",0.32653,0.959,0.507,1246,1,"WNT3A, FZD10, ADCY5, MC1R, ADCY4, WNT4, CREB3L4, CALML6, WNT7B, WNT11",0.294992040666664,0,FALSE +"H2126","Input","KEGG_MELANOMA",-0.3336,-1.17,0.237,15187,0.666,"PIK3CD, FGF18, MAP2K1, EGF, PDGFRA, FGFR1, FGF5, PDGFRB, FGF13, CDKN1A, FGF1, PIK3R1, RAF1, E2F2, FGF22, E2F3, TP53, CDK6, CDKN2A, FGF2, BAD, HRAS, NRAS, PDGFC, AKT3, CDK4",0.625251653989896,0.176525770829699,FALSE +"H2126","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.41418,1.22,0.193,4313,0.815,"GSTA3, ALDH3B2, GSTK1, ALDH3B1, CYP1B1, GSTM5, GSTZ1, GSTA4, GSTO2, GSTM3, MGST1, ALDH1A3, AKR1C2, MGST2, DHDH, CYP2F1, CYP3A43",0.714442690992226,0.0888423912600234,FALSE +"H2126","Input","KEGG_MISMATCH_REPAIR",-0.37099,-1.31,0.158,14311,0.739,"RPA1, POLD2, RFC3, MSH6, MLH1, PCNA, RPA2, RFC1, RPA3, RFC5, RFC4, RFC2",0.801342913045577,0.131355561605174,FALSE +"H2126","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.43345,1.27,0.156,4516,0.743,"INS, CAB39, RPS6KA2, RICTOR, PRKAA2, RPS6KA6, TSC1, PIK3R3, CAB39L, AKT1, RPTOR, MAPK3, VEGFC, PRKAA1, ULK3, VEGFA, MTOR, EIF4B, MAPK1, VEGFD, ULK1",0.806875401645538,0.129011186239425,FALSE +"H2126","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.14128,-0.522,1,12416,0.997,"IFNA13, RAET1G, HCST, CHP2, PLCG1, ICAM1, IFNA21, PPP3CB, IFNGR1, PRKCB, PRF1, NFAT5, IFNA8, PPP3CC, PIK3CG, TNFRSF10C, IFNA1, CD247, TNF, IFNA5, CASP3, IFNB1, GZMB, PPP3R2, LCK, NFATC1, RAC1, PIK3CD, MAP2K1, ULBP1, SHC4, RAET1L, PRKCA, CSF2, SHC3, PPP3R1, ICAM2, PIK3R1, RAF1, TNFRSF10B, NFATC2, SHC2, FAS, ULBP2, ULBP3, HRAS, MICB, NRAS, FYN",0,0.00130484168834428,FALSE +"H2126","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.34377,0.995,0.434,2843,1,"VIPR2, BDKRB2, GHSR, GALR3, P2RY6, CGA, MLNR, BDKRB1, MC1R, SSTR1, F2RL3, P2RX4, GRIN2D, ADORA1, GRIN1, ADRA1D, TRPV1, PTAFR, S1PR4, GABRR2, P2RX2, GABRA3, GABRB3, P2RY2, PLG, GLP2R, DRD4, GH2, LTB4R2, OPRL1, TACR3, LTB4R, TRHR, GRM3",0.362510270487489,0,FALSE +"H2126","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.20862,-0.743,0.857,14936,0.895,"NTRK2, NTRK3, RAC1, IRAK3, PIK3CD, FOXO3, MAPK14, MAP2K1, SHC4, YWHAG, KIDINS220, MAPK7, NTF3, SHC3, GSK3B, NGF, NGFR, RPS6KA4, YWHAE, NFKBIE, CSK, MAPK10, TP73, PIK3R1, RAF1, IRS1, SHC2, CAMK4, CDC42, RHOA, TP53, BDNF, BCL2, JUN, YWHAQ, SH2B3, BAD, HRAS, CALM2, NRAS, AKT3, ARHGDIA, MAP3K3",0.0670191780768018,0.048176964684088,FALSE +"H2126","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.38503,1.13,0.268,2820,0.953,"CD38, NADK, NADSYN1, NT5C2, NMRK1, NAMPT, NMNAT1",0.571865205971211,0.0209070993616736,FALSE +"H2126","Input","KEGG_NITROGEN_METABOLISM",0.42711,1.25,0.148,1139,0.759,"HAL, GLUL, CTH",0.829738284605043,0.11975822410452,FALSE +"H2126","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.25334,0.746,0.86,6235,1,"NOD2, TAB3, XIAP, IKBKB, RELA, MAPK13, BIRC3, TAB1, MAPK3, CXCL2, IKBKG, CARD8, BIRC2, MAPK1, MAPK11, CCL5, NFKBIB, NFKBIA, CASP8, ERBIN, CASP1, MAPK12, NLRP1",0.0655015487564323,0,FALSE +"H2126","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.41668,-1.39,0.093,17589,0.735,"PRKDC, XRCC5, XRCC4, FEN1, NHEJ1",1.03151705144606,0.133712660915805,FALSE +"H2126","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.24966,-0.909,0.511,17114,0.723,"PIK3R1, RAF1, E2F2, E2F3, TP53, CDK6, CDKN2A, BAD, HRAS, NRAS, AKT3, CDK4",0.291579099865287,0.140861702705469,FALSE +"H2126","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.23814,0.704,0.896,4437,1,"NUMB, MAML3, APH1A, RFNG, NOTCH3, PSEN1, DTX1, KAT2A, EP300, DVL1, CTBP1, PSENEN, DTX3",0.0476919903378748,0,FALSE +"H2126","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.32406,-1.14,0.254,16205,0.623,"POLE3, PCNA, RPA2, POLE, RFC1, GTF2H1, RPA3, RFC5, ERCC8, CCNH, GTF2H3, RFC4, RFC2",0.595166283380062,0.20551195334083,FALSE +"H2126","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.57278,1.68,0.0231,4082,0.517,"MGAT4A, DPAGT1, MAN2A2, ST6GAL1, MOGS, RPN2, ALG2, MGAT5B, ALG13, STT3A, MAN1B1, B4GALT1, DPM2, ALG6, ALG8, ALG3, DOLPP1, ALG12, ALG10B, ALG11, RPN1, DDOST, ALG5, B4GALT2, DPM3",1.63638802010786,0.286509456906058,FALSE +"H2126","Input","KEGG_OLFACTORY_TRANSDUCTION",0.26721,0.762,0.815,2307,1,"OR1I1, OR10H2, OR6Q1, OR1F1, OR8B8, OR2A14, OR52B4, GUCA1B, OR6B1, OR10AD1, CALML6, OR52K1, OR2A12, GUCY2D, ARRB2, CNGB1, PRKG2, OR10A3, CAMK2G, OR11H1, OR2A2",0.0888423912600234,0,FALSE +"H2126","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.3714,-1.34,0.115,17549,0.752,"SHMT2, TYMS, MTR, DHFR",0.939302159646388,0.123782159408358,FALSE +"H2126","Input","KEGG_OOCYTE_MEIOSIS",0.22124,0.644,0.945,2630,1,"ADCY5, ADCY4, SMC1B, INS, CALML6, ANAPC2, ITPR1, RPS6KA2, RPS6KA6, SLK, CDC16, CAMK2G, ADCY6, IGF1R, STAG3, ANAPC5",0.0245681914907371,0,FALSE +"H2126","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.65357,1.9,0.00686,5781,0.63,"FUCA1, MAN2C1, AGA, MAN2B2, ENGASE, MAN2B1, MANBA, HEXB, GBA, GLB1, NEU3",2.16367588429325,0.200659450546418,FALSE +"H2126","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.28498,-1.01,0.388,15908,0.633,"COX7C, ATP5MF, NDUFB3, NDUFA11, SDHC, NDUFA8, COX6B2, UQCRQ, NDUFA2, ATP6V1G2, NDUFB8, ATP6V0A2, ATP6V0D1, ATP5F1C, NDUFA9, NDUFAB1, PPA1, SDHB, COX4I1, UQCRC1, NDUFB5, NDUFA1, ATP6V1A, ATP6V0E1, ATP5MC3, ATP5PF, ATP6V1B2, NDUFS3, COX8A, ATP5PO, NDUFS4, NDUFB6, ATP5F1A, ATP6V1H",0.411168274405793,0.198596289982645,FALSE +"H2126","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.44008,1.28,0.127,3870,0.794,"GCNT3, GALNT6, GALNT12, B3GNT6, ST3GAL1, ST6GALNAC1, GALNT3, GALNT14, GALNT4, C1GALT1C1, C1GALT1, GALNT7, GALNT10",0.896196279044043,0.100179497572904,FALSE +"H2126","Input","KEGG_P53_SIGNALING_PATHWAY",-0.35516,-1.26,0.164,15946,0.651,"CCND2, COP1, PMAIP1, RRM2, THBS1, PPM1D, CCNE2, CDKN1A, SESN1, TP73, TNFRSF10B, SERPINE1, FAS, SESN3, TP53, CDK6, STEAP3, CDKN2A, GADD45A, CCNB2, SESN2, CDK1, BBC3, CDK4, CCNG1, CCNB1",0.785156151952302,0.186419011431808,FALSE +"H2126","Input","KEGG_PANCREATIC_CANCER",0.23745,0.701,0.885,4562,1,"CASP9, JAK1, PLD1, TGFBR1, STAT3, IKBKB, RELA, ERBB2, PIK3R3, AKT1, MAPK3, VEGFC, SMAD2, IKBKG, VEGFA, RALBP1, MAPK1, VEGFD, RALB",0.0530567293021746,0,FALSE +"H2126","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.3343,0.984,0.474,5018,1,"PPCS, BCAT2, COASY, PPCDC, ENPP1, PANK2",0.324221658325915,0,FALSE +"H2126","Input","KEGG_PARKINSONS_DISEASE",-0.20922,-0.743,0.887,15759,0.895,"UBE2J2, NDUFB10, COX7C, HTRA2, NDUFB3, SDHC, NDUFA8, COX6B2, UQCRQ, NDUFA2, VDAC2, NDUFB8, ATP5F1C, NDUFA9, NDUFAB1, SDHB, COX4I1, UQCRC1, NDUFB5, NDUFA1, ATP5MC3, ATP5PF, NDUFS3, COX8A, ATP5PO, NDUFS4, NDUFB6, ATP5F1A",0.0520763801682736,0.048176964684088,FALSE +"H2126","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.4175,-1.53,0.0492,16563,0.673,"ARHGEF2, TLR4, TUBB4A, LY96, TUBB4B, ARPC5L, NCL, CDC42, RHOA, TUBA1B, YWHAQ, TUBB2B, TUBA1A, ACTG1, ARPC4, TUBB, ARPC2, TUBB6, ACTB, FYN, TUBB2A",1.30803489723264,0.171984935776023,FALSE +"H2126","Input","KEGG_PATHWAYS_IN_CANCER",0.1848,0.54,0.989,4372,0.997,"WNT3A, FZD10, CASP9, ARNT2, JAK1, WNT4, PLD1, TRAF4, EPAS1, WNT7B, TGFBR1, TRAF2, STAT3, PIAS3, FGF12, WNT11, FGF19, CBLC, XIAP, IKBKB, EGLN2, RELA, ARNT, ERBB2, RXRA, SOS2, IGF1R, FGF11, PDGFB, PLCG2, PIK3R3, CDH1, ITGA2B, BAX, JUP, LAMA3, AKT1, BIRC3, LAMA5, FOXO1, FGFR3, KITLG, MAPK3, STAT5B, VEGFC, RASSF5, EP300, ITGB1, WNT9A, SMAD2, IKBKG, DVL1, CTBP1, SOS1, PRKCG, VEGFA, MTOR, RALBP1, BIRC2, BID, MAPK1, VEGFD",0.0048037084028206,0.00130484168834428,FALSE +"H2126","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.32989,0.976,0.499,6463,1,"GUSB, UGDH, DHDH, CRYL1, UGP2, DCXR, RPEL1",0.30189945437661,0,FALSE +"H2126","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.39083,1.15,0.247,5330,0.949,"G6PD, FBP1, PRPS1, TKTL1, H6PD, PGM1, PRPS1L1, PRPS2, TKT, PGLS, PGM2, PGD, RBKS",0.607303046740334,0.0227337875727074,FALSE +"H2126","Input","KEGG_PEROXISOME",0.39474,1.15,0.245,4935,0.949,"AGXT, PEX11A, GSTK1, ECH1, PEX1, ABCD1, ACSL1, SLC27A2, ACSL3, SCP2, PXMP4, ACOX3, PEX11G, AMACR, PEX12, PEX2, CROT, PEX11B, PEX13, ABCD4, EPHX2, HMGCL, IDH2, ACAA1, PEX7, XDH, PMVK, MPV17, NUDT19, MLYCD, CRAT, IDH1, PEX26, SLC25A17",0.610833915635468,0.0227337875727074,FALSE +"H2126","Input","KEGG_PHENYLALANINE_METABOLISM",0.55039,1.62,0.027,4471,0.454,"ALDH3B2, ALDH3B1, AOC2, TAT, AOC3, ALDH1A3, NAA80, MAOA",1.56863623584101,0.342944147142896,FALSE +"H2126","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.27493,0.81,0.775,4316,1,"OCRL, CALML6, ITPR1, CDS1, INPP4A, PIP4K2C, PIP5K1B, ITPK1, PLCG2, PIK3R3, PI4KB, DGKE, INPP5B, INPPL1, INPP5K, PRKCG, IMPA2, PLCB1, DGKQ",0.11069829749369,0,FALSE +"H2126","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.27303,0.791,0.754,5228,1,"GUSB, HMBS, CP, COX15, BLVRB, ALAD, BLVRA, PPOX",0.122628654130226,0,FALSE +"H2126","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.37557,1.1,0.304,1877,0.915,"PLIN1, CYP4A22, CPT1B, ANGPTL4, ACADM, ACSL1, CPT2, SLC27A2, PPARA, ACSL3, SCP2, ACOX3, RXRA",0.517126416391246,0.0385789059335517,FALSE +"H2126","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.26912,0.792,0.756,2706,1,"SCP2, AMACR, SLC27A5",0.121478204498793,0,FALSE +"H2126","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.40324,1.17,0.215,3895,0.953,"BLNK, CD4, JAK3, CD40, ADA, CD19, IKBKG",0.667561540084395,0.0209070993616736,FALSE +"H2126","Input","KEGG_PRION_DISEASES",-0.36092,-1.26,0.176,15924,0.651,"SOD1, IL1A, NCAM2, IL1B, ELK1, NOTCH1, NCAM1, PRKACA, C5, EGR1, STIP1, FYN",0.75448733218585,0.186419011431808,FALSE +"H2126","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28673,-1.05,0.306,16429,0.667,"MAD2L2, CCNA1, HSP90AA1, MAPK10, ADCY1, CDC25C, PIK3R1, RAF1, PRKACA, ANAPC13, CPEB1, PDE3B, PKMYT1, MAD2L1, BUB1, GNAI1, CCNB2, PLK1, CDK1, CCNA2, CDC25A, HSP90AB1, AKT3, ADCY7, GNAI2, CCNB1",0.51427857351842,0.175874166083451,FALSE +"H2126","Input","KEGG_PROPANOATE_METABOLISM",0.37599,1.11,0.308,5481,0.94,"MCEE, LDHC, ACADM, ALDH6A1, ACACB, SUCLG2, ACSS2, ALDH2, ACACA, ALDH3A2, PCCB, MLYCD, LDHA, LDHAL6B",0.511449283499556,0.0268721464003014,FALSE +"H2126","Input","KEGG_PROSTATE_CANCER",0.22319,0.656,0.929,4356,1,"CASP9, INS, CREB3L4, IKBKB, RELA, ERBB2, CREB3L2, SOS2, ATF4, IGF1R, PDGFB, PIK3R3, AKT1, FOXO1, MAPK3, CREB1, EP300, IKBKG, SOS1, MTOR, SRD5A2, MAPK1",0.0319842860063582,0,FALSE +"H2126","Input","KEGG_PROTEASOME",-0.33383,-1.23,0.178,14960,0.664,"PSMB6, PSMB11, PSMD2, PSMC5, PSMD8, PSMD13, PSMA4, PSMB2, PSMD1, PSMD14, PSMA1, PSMB1, PSMC3, PSMA2, PSMB7, PSMD6",0.749579997691106,0.177831920631982,FALSE +"H2126","Input","KEGG_PROTEIN_EXPORT",0.47612,1.41,0.0757,6187,0.67,"SRPRA, SRP54, SPCS2, IMMP1L, SEC61A1, OXA1L, SEC62, SPCS3, SPCS1, SRP72, HSPA5, SRPRB, SRP68, SEC61B, IMMP2L",1.12090412049993,0.173925197299174,FALSE +"H2126","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.28306,-1.01,0.382,15771,0.633,"PCK2, ATP1A3, SLC38A3, MDH1, CA2, ATP1A1, GLS",0.417936637088291,0.198596289982645,FALSE +"H2126","Input","KEGG_PURINE_METABOLISM",0.27774,0.809,0.745,4157,1,"ADCY5, ENTPD8, PDE4D, ADCY4, CANT1, PRUNE1, PDE8B, PDE4A, GUCY2D, PRPS1, POLR2J2, NT5C2, ENTPD2, ENTPD5, ADCY6, ENTPD6, POLR3F, POLR3GL, NME3, AK7, GMPR2, NUDT9, GDA, PRPS1L1, ADA, POLD4, PDE10A, POLR2J3, PAPSS2, PDE5A, PRPS2, ITPA, ENPP1, XDH, AMPD3, POLR2K",0.127843727251707,0,FALSE +"H2126","Input","KEGG_PYRIMIDINE_METABOLISM",0.18309,0.535,0.997,4292,0.991,"ENTPD8, TYMP, CANT1, CMPK1, POLR2J2, NT5C2, ENTPD5, ENTPD6, POLR3F, POLR3GL, NME3, TXNRD1, POLD4, POLR2J3, ITPA, CAD, POLR2K, CTPS2, CDA",0.00130484168834428,0.00392634551472468,FALSE +"H2126","Input","KEGG_PYRUVATE_METABOLISM",0.28879,0.84,0.706,5481,1,"LDHC, ACACB, LDHD, ACSS2, ALDH2, ACACA, PC, ALDH3A2, HAGH, DLAT, MDH2, PDHA1, ME1, LDHA, GRHPR, DLD, LDHAL6B",0.151195298948196,0,FALSE +"H2126","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.20719,0.606,0.968,4066,1,"BDKRB2, BDKRB1, CD14, ITGB2, INS, VAV1, ARHGEF4, FGF12, FGF19, SLC9A1, ITGB6, SSH3, RDX, PIP4K2C, PIP5K1B, WASL, ITGB5, SOS2, ITGA1, MYH14, PAK4, PAK6, ARPC1A, ITGAL, FGF11, PDGFB, PIK3R3, ITGA2B, ARHGAP35, IQGAP1, ARPC1B, VAV2, FGFR3, ARHGEF1, MAPK3, ARHGEF12, ARHGEF7, ROCK1, ITGB1, FGD3, SOS1, TIAM1, RRAS",0.0141246426916063,0,FALSE +"H2126","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.24372,0.714,0.881,5460,1,"INS, PRKAA2, ATG4C, PRKAA1, ULK3, ULK1, GABARAPL1, ULK2, BECN2",0.0550240915879521,0,FALSE +"H2126","Input","KEGG_RENAL_CELL_CARCINOMA",0.25122,0.743,0.847,4372,1,"ARNT2, GAB1, EPAS1, EGLN2, ARNT, SOS2, PAK4, PAK6, PDGFB, PIK3R3, AKT1, MAPK3, VEGFC, EP300, SOS1, VEGFA, MAPK1, VEGFD",0.0721165896692931,0,FALSE +"H2126","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.32455,0.951,0.511,2328,1,"CTSA, ACE2, NLN",0.291579099865287,0,FALSE +"H2126","Input","KEGG_RETINOL_METABOLISM",0.4369,1.3,0.114,4313,0.788,"CYP4A22, CYP2A7, RDH10, DGAT1, CYP2A6, RDH16, CYP26B1, PNPLA4, DHRS3, ALDH1A2, DGAT2, RDH11, CYP26C1, CYP3A43",0.943095148663527,0.103473782510445,FALSE +"H2126","Input","KEGG_RIBOFLAVIN_METABOLISM",0.55933,1.66,0.021,5192,0.411,"RFK, ACP6, PHPT1, ACP1, FLAD1, ENPP1, ACP2",1.67778070526608,0.386158178123931,FALSE +"H2126","Input","KEGG_RIBOSOME",-0.24649,-0.913,0.633,17221,0.736,"RPS12, RPL29, RPS26, RPL22L1, FAU, RPL24, RPL35, RPL5, RPL15, RPL35A, RPL26L1, RPL32, RPL14, RPSA, RPS20, RPL17",0.198596289982645,0.133122185662501,FALSE +"H2126","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.22133,0.666,0.932,6603,1,"IRF3, TRAF2, NLRX1, DHX58, IKBKB, RELA, TKFC, TRADD, MAPK13, TBK1, IKBKG, MAVS, TRAF3, OTUD5, MAPK11, NFKBIB, FADD, NFKBIA, DDX3X, CASP8, IFIH1, TRIM25, MAPK12, RIPK1, CASP10, TBKBP1",0.0305840876460186,0,FALSE +"H2126","Input","KEGG_RNA_DEGRADATION",-0.3358,-1.15,0.247,17314,0.638,"EXOSC9, EXOSC7, LSM1, CNOT10, PATL1, EXOSC3, HSPD1, DCP2, LSM6, LSM5, LSM3, ENO2, DCP1B",0.607303046740334,0.195179321278838,FALSE +"H2126","Input","KEGG_RNA_POLYMERASE",-0.19769,-0.705,0.855,17487,0.932,"POLR1E, POLR2D, POLR2E",0.0680338852718274,0.0305840876460186,FALSE +"H2126","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.33451,0.976,0.489,3468,1,"BUD23, CTH, AHCYL1, METTL2B, HEMK1, AHCYL2, PAPSS2",0.31069114087638,0,FALSE +"H2126","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.21519,0.631,0.955,3187,1,"CASP9, TRAF4, TRAF2, PIAS3, XIAP, IKBKB, RELA, RXRA, PIK3R3, APAF1, ITGA2B, LAMA3, AKT1, BIRC3, LAMA5",0.0199966284162537,0,FALSE +"H2126","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.33582,0.992,0.45,4565,1,"GOSR2, BET1, BET1L, STX19, GOSR1, STX17, VAMP7, STX16, SNAP23, VAMP8, YKT6, VTI1B, SEC22B, VAMP4, STX1A",0.346787486224656,0,FALSE +"H2126","Input","KEGG_SPHINGOLIPID_METABOLISM",0.28133,0.833,0.709,2479,1,"SGPP1, ARSA, DEGS2, PLPP3, GALC, ASAH1, ENPP7",0.149353764816933,0,FALSE +"H2126","Input","KEGG_SPLICEOSOME",-0.31632,-1.12,0.268,16081,0.571,"PRPF18, SNRPD2, SF3B6, RBMX, CDC5L, SRSF3, MAGOHB, HNRNPU, SF3A2, LSM2, SNRPD1, HSPA8, SRSF1, HSPA6, HNRNPC, HNRNPA1, PPIL1, SYF2, SF3B3, ALYREF, HNRNPM, SRSF10, SNRPB, HNRNPK, U2SURP, PQBP1, HNRNPA1L2, TRA2B, SMNDC1, SF3B5, HNRNPA3, ISY1, SNRPE, SNRPC, U2AF1, LSM6, BCAS2, PRPF19, LSM5, LSM3, TXNL4A",0.571865205971211,0.243363891754152,FALSE +"H2126","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.3691,1.1,0.317,5886,0.915,"GYS1, HK2, GUSB, UGDH, GAA, PGM1, PYGL, ENPP1, MGAM, PGM2, UGP2, G6PC2, PYGB",0.498940737782249,0.0385789059335517,FALSE +"H2126","Input","KEGG_STEROID_BIOSYNTHESIS",0.45101,1.32,0.118,5705,0.788,"MSMO1, CYP27B1, LIPA, NSDHL, DHCR7, DHCR24, SC5D, TM7SF2",0.928117992693875,0.103473782510445,FALSE +"H2126","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38017,1.12,0.29,4720,0.968,"SRD5A3, SULT2B1, CYP1B1, CYP11B1, HSD17B8, SRD5A1, COMT, AKR1C2, SRD5A2, CYP3A43, HSD17B2",0.537602002101044,0.0141246426916063,FALSE +"H2126","Input","KEGG_SULFUR_METABOLISM",0.56845,1.66,0.015,4359,0.411,"SULT2B1, SULT1A3, SUOX, SULT1A4, PAPSS2, CHST11, SULT1A2, CHST12",1.82390874094432,0.386158178123931,FALSE +"H2126","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.31191,-1.12,0.301,11837,0.571,"CTSG, FCGR2B, CD80, C9, IL10, C6, C7, CD86, FCGR2C, TNF, GRIN2A, SNRPD3, GRIN2B, ELANE, ACTN2, FCGR2A, SNRPD1, SSB, C5, C1R, SNRPB, ACTN1",0.521433504406157,0.243363891754152,FALSE +"H2126","Input","KEGG_TASTE_TRANSDUCTION",0.43734,1.28,0.141,3465,0.794,"TAS2R3, TAS1R3, TAS2R4, ADCY4, SCNN1A, TAS2R38, ADCY6, TAS2R10, TAS2R5, TAS2R39, CACNA1A, TAS2R41",0.85078088734462,0.100179497572904,FALSE +"H2126","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.28006,0.83,0.711,1945,1,"CSAD",0.148130399270234,0,FALSE +"H2126","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.31235,0.923,0.559,4183,1,"DHDDS, MVD, PDSS2, PMVK",0.252588192113577,0,FALSE +"H2126","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.22574,0.67,0.92,3917,1,"INHBB, TGFBR1, BMP6, SP1, BMP7, ID1, THBS3, BMP8B, SMURF1, LTBP1, ID3, RBL2, BMP8A, MAPK3, EP300, ROCK1, PPP2R1B, SMAD2, E2F5",0.0362121726544447,0,FALSE +"H2126","Input","KEGG_THYROID_CANCER",-0.32728,-1.21,0.163,17604,0.662,"PAX8, NCOA4, TP53, TCF7, HRAS, NRAS",0.787812395596042,0.1791420105603,FALSE +"H2126","Input","KEGG_TIGHT_JUNCTION",-0.22937,-0.799,0.744,15576,0.882,"CLDN11, CASK, CLDN22, JAM2, PARD3, PRKCA, MYLPF, PPP2R2A, MYL5, RAB3B, CSNK2A2, MYH9, PPP2R2B, MYH15, RRAS2, MRAS, LLGL1, MAGI2, JAM3, CDC42, TJAP1, RHOA, MYL9, GNAI1, ACTN1, ACTG1, HRAS, PARD6G, NRAS, MPDZ, CSNK2B, AKT3, CDK4, GNAI2, PPP2R2D, ACTB, EPB41L2",0.128427064454121,0.0545314148681803,FALSE +"H2126","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.26952,0.801,0.758,3895,1,"LBP, CD14, TIRAP, IRAK4, IRF3, MAP3K8, IKBKB, RELA, PIK3R3, CD40, MAPK13, AKT1, MAP2K7, TAB1, TBK1, MAPK3, TLR3, MYD88, IKBKG",0.120330794367946,0,FALSE +"H2126","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.28315,-0.974,0.418,16065,0.643,"TPH1, WARS2, AOX1, KYNU, OGDHL, CYP1A1, ALDH1B1, ECHS1, ACAT1, ALDH9A1, AADAT",0.378823718224965,0.191789027075778,FALSE +"H2126","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.37967,1.11,0.285,4356,0.94,"IRS2, INS, HK2, CACNA1D, IKBKB, SOCS2, PIK3R3, CACNA1A, MAPK3, SOCS4, PRKCD, MTOR, MAPK1",0.54515513999149,0.0268721464003014,FALSE +"H2126","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.46804,1.35,0.112,1507,0.797,"CPE, INS, ICA1, PTPRN2",0.950781977329818,0.0985416786038876,FALSE +"H2126","Input","KEGG_TYROSINE_METABOLISM",0.48019,1.41,0.0734,2664,0.67,"TH, ALDH3B2, ALDH3B1, BUD23, HGD, AOC2, TAT, GSTZ1, METTL2B, AOC3, COMT, HEMK1",1.13430394008393,0.173925197299174,FALSE +"H2126","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.17101,-0.639,0.97,15187,0.978,"PIK3CD, MAP3K14, MAPK14, MAP2K1, CD8A, MAP3K7, CARD11, CSF2, RASGRP1, PAK3, GSK3B, PPP3R1, NFKBIE, DLG1, PIK3R1, RAF1, NFATC2, CDC42, RHOA, JUN, HRAS, NRAS, BCL10, AKT3, MALT1, CDK4, FYN",0.0132282657337552,0.00966114521239857,FALSE +"H2126","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.22621,0.681,0.918,4294,1,"RHOBTB2, PPIL2, CUL7, ANAPC2, CUL5, PIAS3, CBLC, XIAP, FBXW8, UBOX5, UBE4A, CDC16, UBE2Q1, SMURF1, SYVN1, HERC1, UBE2Q2, FBXO4, UBE2H, NHLRC1, UBE2M, ANAPC5, DET1, UBE2G2, WWP1, BIRC3, MID1, HUWE1, ITCH, ANAPC11, BTRC, DDB2, UBE2G1, BIRC2",0.0371573187987575,0,FALSE +"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.3008,0.881,0.636,2403,1,"BCAT2, VARS2",0.196542884351586,0,FALSE +"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.30329,0.887,0.639,4339,1,"MCEE, ACAD8, ACADM, ALDH6A1, BCAT2, BCKDHA, AUH, OXCT2, ACADS, HMGCL, ALDH2, ALDH3A2, ACAA1, HADHB, PCCB",0.1944991418416,0,FALSE +"H2126","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.28432,0.837,0.722,4652,1,"ADCY5, CYP4A22, ADCY4, PLA2G6, CALML6, ITPR1, ADRA1D, CACNA1D, PLA2G12A, PPP1R14A, PLA2G10, ADCY6, PRKCH, PLA2G2D, PLA2G2C, ARHGEF1, MAPK3, PRKCD, ARHGEF12, ROCK1, PLA2G4A, PRKCG, PLCB1, KCNMB3, MAPK1, CACNA1F, GNAQ, PLA2G4B, NPR2",0.141462802430361,0,FALSE +"H2126","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.25984,0.779,0.8,3924,1,"AQP3, CREB3L4, RAB11B, NSF, CREB3L2, ADCY6, DYNC1LI2, RAB5B, CREB1, DYNC2LI1",0.0969100130080564,0,FALSE +"H2126","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.25173,0.74,0.853,4798,1,"CASP9, PLA2G6, PLA2G12A, PLA2G10, PLCG2, PLA2G2D, PIK3R3, MAPK13, AKT1, PLA2G2C, MAPK3, PLA2G4A, MAPKAPK2, PRKCG, VEGFA, MAPK1, PLA2G4B, MAPK11, PXN",0.069050968832477,0,FALSE +"H2126","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.28025,0.814,0.733,4398,1,"ATP6V1B1, ATP6V0A4, ATP6AP1, KDELR3, PDIA4, ERO1A, TCIRG1, PLCG2, KDELR1, KDELR2, ATP6V0B, ATP6V0E2, PRKCG, SEC61A1, ATP6V1G1, ARF1, TJP2",0.134896025358872,0,FALSE +"H2126","Input","KEGG_VIRAL_MYOCARDITIS",0.22878,0.67,0.923,2655,1,"CASP9, ITGB2, CD55, MYH14, ITGAL, CD40",0.0347982989740879,0,FALSE +"H2126","Input","KEGG_WNT_SIGNALING_PATHWAY",0.2155,0.644,0.958,1426,1,"WNT3A, FZD10, CSNK1E, FRAT1, WNT4, WNT7B, WNT11, LRP5, FRAT2",0.0186344909214556,0,FALSE +"H520","Input","KEGG_ABC_TRANSPORTERS",0.22153,0.619,0.958,3230,1,"ABCC5, ABCB7, ABCA7, ABCA3, ABCC2, ABCD4, ABCC8",0.0186344909214556,0,FALSE +"H520","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.46206,1.31,0.121,3881,0.59,"ZBTB16, EIF4EBP1, TCF7, RUNX1, MAP2K1, MAP2K2, LEF1, TCF7L2, PIK3CA, BRAF, RAF1, MTOR, SOS1, PIK3CB, RPS6KB2, SOS2, PIK3R2, AKT2",0.91721462968355,0.229147988357856,FALSE +"H520","Input","KEGG_ADHERENS_JUNCTION",-0.31888,-1.16,0.198,17653,0.643,"MET, PTPRB, SNAI2, PTPN1, SNAI1, RAC2, VCL, NECTIN2, PTPRM, IQGAP1, PTPRJ, CDC42, ACTB, ERBB2, RHOA, EGFR, INSR, TGFBR2, IGF1R, BAIAP2",0.703334809738469,0.191789027075778,FALSE +"H520","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.26156,0.739,0.86,4366,1,"ADIPOQ, PRKCQ, PCK2, PTPN11, STK11, MAPK9, MTOR, CAMKK2, PRKAG1, NFKBIB, SLC2A1, ADIPOR1, AKT2, PRKAB2, ACACB",0.0655015487564323,0,FALSE +"H520","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.41546,1.17,0.241,3710,0.772,"GPT2, GLUD2, GOT2, ASNS, CAD, GAD1, GLUL, PPAT, ASS1",0.617982957425132,0.112382699664264,FALSE +"H520","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.26264,0.732,0.862,2852,1,"IGF1, KCNJ1, PIK3CA, PDPK1, SCNN1A, PIK3CB",0.0644927341752872,0,FALSE +"H520","Input","KEGG_ALLOGRAFT_REJECTION",-0.31593,-1.1,0.279,17766,0.718,"CD40, IL12A, FAS",0.554395796726402,0.1438755557577,FALSE +"H520","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.30686,0.857,0.7,3580,1,"PLA2G12A, FADS2, PLA2G3",0.154901959985743,0,FALSE +"H520","Input","KEGG_ALZHEIMERS_DISEASE",0.3064,0.851,0.7,5666,1,"NDUFS5, ITPR1, NDUFS7, ADAM10, CASP7, ATP2A1, NDUFB10, COX4I1, UQCR11, SDHB, NDUFA2, NDUFA10, ATP5F1D, NAE1, LPL, NDUFA9, COX7C, ERN1, COX7A2L, NDUFA7, PPP3R1, ATP5F1C, UQCRQ, CALML5, NDUFA4L2, COX5A, NDUFAB1, GSK3B, NDUFC2, ATP5MC3, NDUFB6, APH1A, PSEN2, MME, CDK5R1, PLCB1, NDUFB7, UQCRC2, NDUFS6, NDUFA4, ATP2A2, NDUFS3, NDUFA1, UQCRHL, NDUFB9, CYC1, CALML6, RYR3, NDUFB1, ADAM17, NDUFC1, PSEN1, UQCRB, MAPK1, ATP5F1A, NDUFV1, NDUFB5, CALML3",0.154901959985743,0,FALSE +"H520","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.50499,1.41,0.0727,7188,0.594,"WARS2, RARS2, EARS2, SEPSECS, HARS2, FARSB, MARS2, MTFMT, CARS2, LARS2, IARS2, PARS2, FARSA, TARS2",1.13846558914096,0.226213555018806,FALSE +"H520","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.45499,-1.63,0.0222,16174,1,"GCK, NPL, RENBP, FPGT, UGDH, UAP1, GMPPA, UXS1, CYB5R1, HEXB, CYB5R3, NAGK, GALK1, CMAS, GALE, NANP, PGM1",1.65364702554936,0,FALSE +"H520","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.28112,0.784,0.807,1987,1,"SLC1A2, SOD1, NEFL, DERL1, MAP2K6",0.0931264652779296,0,FALSE +"H520","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.29611,0.83,0.723,1328,1,"IFNA5, NFYC, RFXAP, NFYB, CANX, CREB1",0.140861702705469,0,FALSE +"H520","Input","KEGG_APOPTOSIS",-0.2831,-0.99,0.436,14862,0.747,"BCL2, IRAK4, PPP3R2, TNF, CASP8, PIK3R1, PRKAR2B, PRKAR2A, NFKBIA, TNFRSF10C, IRAK3, AKT3, IKBKB, IL1A, TNFRSF1A, IL1B, NGF, BAX, ENDOD1, BID, BIRC3, TP53, PIK3CD, CASP10, TRADD, TNFRSF10D, CAPN2, FAS, IL1RAP, CAPN1, MAP3K14",0.360513510731414,0.126679398184601,FALSE +"H520","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.17423,-0.633,0.932,13977,0.959,"ALOX15, CYP2C8, PLA2G1B, CYP4A22, CYP4F3, GGT6, GGT7, PTGS1, PTGIS, GGT5, CBR3, PTGDS, ALOX5, PTGES2, PTGS2, CYP2E1, GPX1, PTGES, EPHX2",0.0305840876460186,0.0181813928293364,FALSE +"H520","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.36736,1.04,0.39,3744,0.831,"SMS, GLUD2, ARG2, GOT2, MAOB, PYCR1, CKB, ALDH2, ALDH9A1, PYCR2, SAT1, GLUL, ASS1, ALDH3A2",0.408935392973501,0.080398976215889,FALSE +"H520","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.23383,-0.825,0.667,14536,0.885,"ITGA7, SGCD, ITGA10, TCF7L1, ACTN1, ITGA1, SGCA, ACTN2, CACNG7, DES, ITGA2, ITGB5, CACNA2D4, ITGA2B, ITGA11, CACNA1C, CACNG6, ACTG1, CACNG4, ITGA4, CACNG8, ITGAV, ITGB8, ITGB6, GJA1, ITGB3, CACNA2D1, ITGA5, LMNA, DAG1, ITGB1, ACTB, ITGA3, CACNB3",0.175874166083451,0.0530567293021746,FALSE +"H520","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.55198,1.53,0.0445,4712,0.7,"UGT2A1, MIOX, ALDH2, ALDH9A1, ALDH3A2, ALDH7A1",1.35163998901907,0.154901959985743,FALSE +"H520","Input","KEGG_ASTHMA",0.64109,1.8,0.00449,55,0.886,"EPX",2.34775365899668,0.0525662781129492,FALSE +"H520","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.62081,1.73,0.00783,438,0.351,"CTLA4, IFNA5, PRF1",2.10623823794206,0.454692883534176,FALSE +"H520","Input","KEGG_AXON_GUIDANCE",-0.26297,-0.937,0.462,17072,0.753,"CDK5, EPHB6, SEMA3E, EFNB3, NFATC2, SLIT2, CFL1, NGEF, MET, SEMA4A, EFNB2, EFNB1, EPHA2, NRP1, NFATC1, EFNA3, SEMA7A, RAC2, ABLIM3, ITGB1, NTN4, CDC42, L1CAM, SEMA3A, EFNA1, EPHB2, EFNA5, RHOA, SEMA4B, PLXNB2, SRGAP1, SEMA3C",0.335358024443874,0.123205023799299,FALSE +"H520","Input","KEGG_BASAL_CELL_CARCINOMA",0.39497,1.1,0.314,4056,0.874,"DVL3, AXIN2, TCF7, SHH, APC, FZD1, LEF1, WNT11, TCF7L2, FZD3, PTCH2, AXIN1, CTNNB1, FZD10, GSK3B, BMP4, WNT8B",0.503070351926785,0.058488567365597,FALSE +"H520","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.43897,1.22,0.191,4856,0.666,"GTF2F1, TAF1, GTF2A2, TBP, TAF6L, GTF2A1, GTF2H3, TAF7, TAF2, TAF5, TAF1L, TAF9B, TAF11, GTF2IRD1",0.718966632752272,0.176525770829699,FALSE +"H520","Input","KEGG_BASE_EXCISION_REPAIR",0.33446,0.945,0.542,6120,0.923,"MUTYH, MBD4, POLD3, TDG, LIG3, NEIL1, POLL, NTHL1, POLE, FEN1, POLE4, XRCC1, POLE3, POLD2, OGG1, NEIL3",0.266000713461613,0.0347982989740879,FALSE +"H520","Input","KEGG_BETA_ALANINE_METABOLISM",0.5122,1.43,0.0611,5769,0.655,"SMS, ALDH2, ALDH9A1, CNDP1, HADHA, GAD1, HIBCH, ALDH3A2, ALDH7A1, AOC3, EHHADH, MLYCD, AOC2",1.21395878975745,0.183758700008217,FALSE +"H520","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.26181,0.727,0.862,3576,1,"HACD2, PECR, HADHA, FADS2, HSD17B12, TECR",0.0644927341752872,0,FALSE +"H520","Input","KEGG_BLADDER_CANCER",-0.2505,-0.899,0.586,17931,0.799,"CXCL8, PGF, TYMP, VEGFC, DAPK1, CDKN1A, TP53, ERBB2, EGFR",0.232102383981909,0.0974532206860086,FALSE +"H520","Input","KEGG_BUTANOATE_METABOLISM",0.38102,1.07,0.33,5901,0.91,"OXCT2, ALDH2, PDHA1, ALDH9A1, HADH, HADHA, GAD1, L2HGDH, ALDH3A2, AACS, ALDH7A1, EHHADH, BDH1, ACAT1",0.481486060122112,0.0409586076789064,FALSE +"H520","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.24486,0.679,0.91,4278,1,"SYK, MALT1, NFATC3, MAP2K1, MAP2K2, PIK3CA, RAF1, SOS1, PPP3R1, PIK3CB, NFKBIB, GSK3B, SOS2, PIK3R2, AKT2, RAC3, PTPN6",0.0409586076789064,0,FALSE +"H520","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.28608,0.812,0.765,3460,1,"CACNA1E, CHRM3, HTR2C, SLC8A1, PHKB, ADCY7, ITPR1, SLC25A4, MYLK2, CHRNA7, GNAL, ATP2A1, VDAC2, GNA11, PHKA2, LTB4R2, ADRB1, VDAC1, PHKA1, ERBB4, PPP3R1, SLC25A5, PRKX, CACNA1B, ADCY1, PRKACB, PPID, CALML5",0.116338564846382,0,FALSE +"H520","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.16116,0.449,0.998,5367,0.999,"SLC8A1, CACNA2D3, COX4I1, UQCR11, COX7C, COX7A2L, UQCRQ, COX5A, UQCRC2, ATP2A2, UQCRHL, CYC1, ATP1B3, ATP1B1, UQCRB",0.000869458712628891,0.000434511774017692,FALSE +"H520","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.29701,0.846,0.709,1475,1,"CTLA4, SELE, NRXN3, MADCAM1, CNTN1, NRCAM, NLGN3, CADM1",0.149353764816933,0,FALSE +"H520","Input","KEGG_CELL_CYCLE",0.44489,1.25,0.164,5198,0.688,"RAD21, GADD45G, CDC14A, ORC6, CDC23, FZR1, ORC3, STAG2, ORC2, ESPL1, TGFB2, CDC20, CCNB2, CDK1, CHEK1, MCM2, PLK1, CREBBP, BUB1B, CDKN2D, SMAD4, CDC25C, ATM, RBL1, E2F2, MAD2L1, PKMYT1, TTK, ANAPC7, STAG1, BUB3, SKP2, E2F4, ANAPC1, ORC5, ZBTB17, ORC4, CDKN2A, GSK3B, RBL2, E2F1, CDC27, BUB1, MAD2L2, MCM6, RB1, CCNH, SKP1, ATR, CDK6, SMAD2, ANAPC11, CCNA2, EP300, HDAC2, MCM3, CDC14B",0.785156151952302,0.162411561764489,FALSE +"H520","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.20211,0.561,0.983,4667,1,"CXCL14, CCL27, XCL1, ADCY7, CXCR4, GRK6, PAK1, ELMO1, MAP2K1, GNB1, XCL2, PIK3CA, BRAF, RAF1, SOS1, TIAM1, GNG2, PIK3CB, PRKX, WAS, NFKBIB, ADCY1, PRKACB, GSK3B, GSK3A, SOS2, PIK3R2, AKT2, CXCR2, GRK2, GNG7, PTK2, PLCB1, PRKCZ, GNAI1, CRKL, GNB3",0.00744648216786438,0,FALSE +"H520","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.31649,0.875,0.65,5613,1,"RUNX1, MAP2K1, MAP2K2, CTBP1, PIK3CA, PTPN11, TGFB2, BRAF, RAF1, CBL, SOS1, SMAD4, E2F2, PIK3CB, CDKN2A, SOS2, PIK3R2, AKT2, E2F1, TGFBR1, RB1, CRKL, CDK6, BCL2L1, HDAC2, MAPK1, CTBP2, CRK, MYC, E2F3",0.187086643357144,0,FALSE +"H520","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.22889,-0.768,0.744,17633,0.881,"PER1, BHLHE41",0.128427064454121,0.0550240915879521,FALSE +"H520","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.2508,0.702,0.908,5651,1,"PCK2, PDHA1, SDHB, IDH1, FH, DLAT, DLST, SUCLA2, SUCLG1",0.0419141514789149,0,FALSE +"H520","Input","KEGG_COLORECTAL_CANCER",0.36715,1.01,0.429,4149,0.862,"AXIN2, TCF7, APC, MAP2K1, LEF1, TCF7L2, PIK3CA, TGFB2, BRAF, RAF1, MAPK9, SMAD4, AXIN1, PIK3CB, CTNNB1, BIRC5, GSK3B, APPL1, PIK3R2, AKT2, TGFBR1, RAC3",0.367542707815276,0.0644927341752872,FALSE +"H520","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.3245,-1.17,0.222,15340,0.743,"VWF, A2M, C4A, C3AR1, CD55, C1S, C4BPB, SERPING1, CFB, PROS1, THBD, BDKRB1, CFI, SERPINA1, BDKRB2, CFH, F3, C3, PLAT, SERPINE1, F2R, PLAU, TFPI, CD59, PLAUR",0.653647025549361,0.129011186239425,FALSE +"H520","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.4262,1.18,0.215,5408,0.757,"SMS, GOT2, CBS, MAT2A, MAT2B, APIP, DNMT3B, ADI1, DNMT3A, MTAP, AHCY, DNMT1",0.667561540084395,0.120904120499927,FALSE +"H520","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.24216,-0.863,0.61,16314,0.816,"PDGFC, IL18R1, TNFRSF6B, IL1A, CSF2, CCL5, VEGFB, CXCR6, PDGFRB, TNFRSF11A, PDGFA, LEPR, IFNAR2, IL7, TNFSF15, TNFRSF1A, IL1B, CCL20, CSF2RA, CCL26, CD70, CXCL16, CX3CL1, BMP2, CCR10, IL7R, CCL28, IL6, TNFRSF25, INHBA, IL17RA, CXCL3, MET, IFNGR1, CXCL1, CD40, ACVR2A, TGFB3, CXCL2, CXCL8, CTF1, IL12A, TNFSF12, VEGFC, TNFSF13, TNFSF9, ACVR1, IL18, TNFRSF14, IL6R, TNFRSF10D, PLEKHO2, TGFB1, CSF1, OSMR, LIF, FAS, IL6ST, CLCF1, EGFR, IL1RAP, TGFBR2, IL4R, TNFRSF12A",0.214670164989233,0.0883098412461389,FALSE +"H520","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.27384,-0.973,0.477,15432,0.738,"CXCL10, AIM2, POLR3H, NFKBIA, RIPK3, IKBKB, DDX58, CCL5, IL1B, IL6, CASP1, POLR1C, IRF3, TBK1, IL18, POLR3F, IKBKE",0.321481620959886,0.131943638176958,FALSE +"H520","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.29087,-1.06,0.344,15170,0.721,"ITGA1, TNF, SGCA, TNNC1, CACNG7, DES, ITGA2, ITGB5, CACNA2D4, ITGA2B, ITGA11, ADCY4, CACNA1C, CACNG6, ACTG1, CACNG4, ITGA4, CACNG8, ITGAV, ITGB8, ITGB6, GNAS, ITGB3, TNNI3, CACNA2D1, TGFB3, TPM1, ITGA5, LMNA, ADCY9, DAG1, ITGB1, TGFB1, TPM2, ACTB, ITGA3, CACNB3",0.46344155742847,0.142064735280571,FALSE +"H520","Input","KEGG_DNA_REPLICATION",0.48576,1.35,0.088,6012,0.618,"RFC4, RNASEH1, DNA2, POLA1, POLD3, MCM2, RNASEH2C, MCM6, RNASEH2B, RFC1, POLE, RFC5, RPA4, FEN1, POLE4, PRIM2, MCM3, MCM7, POLE3, POLD2, RNASEH2A, RPA2, RFC3, POLA2",1.05551732784983,0.209011524911184,FALSE +"H520","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.40979,-1.46,0.0619,18696,0.66,"ETV6, EGFR, ETS2, ETS1, SPIRE1",1.20830935097988,0.180456064458131,FALSE +"H520","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.21311,-0.773,0.779,16067,0.891,"GSTM1, GSTM3, GSTT2, FMO4, CYP2E1, AOX1, GSTM4, MAOA, GSTO1, ALDH3B1, GSTK1, MGST3",0.108462542327436,0.0501222959631252,FALSE +"H520","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.26675,0.752,0.836,1088,1,"UCK2, UGT2A1, CES1, GMPS",0.0777937225609836,0,FALSE +"H520","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.43593,-1.56,0.044,15170,0.674,"ITGA1, GP6, RELN, VWF, LAMC3, COL11A1, ITGA2, COL5A1, COL5A3, ITGB5, THBS2, ITGA2B, CD36, COL6A3, ITGA11, COL6A2, SDC3, ITGA4, COL3A1, LAMA1, COL1A2, LAMC2, SDC2, COL5A2, ITGAV, ITGB8, COL4A2, ITGB6, ITGB3, LAMA4, LAMB2, COL6A1, COL1A1, AGRN, LAMA3, ITGA5, TNC, COL4A1, DAG1, LAMA5, ITGB1, LAMB3, SDC4, ITGA3, HSPG2, LAMB1",1.35654732351381,0.17134010346468,FALSE +"H520","Input","KEGG_ENDOCYTOSIS",-0.20867,-0.741,0.824,17598,0.871,"ADRB2, ARFGAP1, VPS37D, LDLRAP1, MET, FGFR2, STAM, PARD6B, ASAP3, CHMP4B, ARAP2, ACAP1, HSPA1B, ARAP3, DAB2, F2R, SMURF1, CDC42, PLD1, EHD1, RAB31, CLTCL1, EHD2, EGFR, ARAP1, ARRB1, IQSEC2, IGF1R, RAB11FIP5",0.0840727883028842,0.0599818449923368,FALSE +"H520","Input","KEGG_ENDOMETRIAL_CANCER",0.48157,1.36,0.0918,3881,0.617,"CTNNA2, AXIN2, TCF7, APC, MAP2K1, MAP2K2, LEF1, TCF7L2, PIK3CA, PDPK1, BRAF, RAF1, CTNNA1, SOS1, AXIN1, PIK3CB, CTNNB1, GSK3B, SOS2, PIK3R2, AKT2",1.03715731879876,0.209714835966758,FALSE +"H520","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.24316,0.675,0.923,3902,1,"PTPRZ1, ATP6V0B, PAK1, ATP6V0A2, ATP6V1E2, ADAM10, PTPN11, MAPK9, GIT1, ATP6V1G2, ATP6V0C, ATP6V1H, F11R, CXCR2",0.0347982989740879,0,FALSE +"H520","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.30689,0.84,0.736,4593,1,"EIF4EBP1, PAK2, PAK1, MAP2K1, MAP2K7, MAP2K2, NRG3, PIK3CA, BRAF, RAF1, MAPK9, MTOR, CBL, SOS1, ERBB4, PIK3CB, RPS6KB2, NCK1, GSK3B, SOS2, PIK3R2, AKT2, PTK2, CAMK2G, MAP2K4, TGFA, CRKL",0.133122185662501,0,FALSE +"H520","Input","KEGG_ETHER_LIPID_METABOLISM",0.31444,0.871,0.661,3580,1,"PLA2G7, CHPT1, PLA2G12A, PAFAH1B2, PAFAH2, PLA2G3",0.17979854051436,0,FALSE +"H520","Input","KEGG_FATTY_ACID_METABOLISM",0.37333,1.05,0.381,6710,0.854,"ECI1, ACAA2, ALDH2, ALDH9A1, HADH, HADHA, ADH5, ALDH3A2, ALDH7A1, CPT1B, ADH6, ACADSB, EHHADH, CPT1A, ACAT1, ECI2, CPT2, GCDH, ACSL5, ECHS1, ADH1C",0.419075024324381,0.068542129310995,FALSE +"H520","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.31452,0.882,0.655,4149,1,"SYK, MAP2K1, MAP2K7, MAP2K2, PIK3CA, PDPK1, MAP2K6, RAF1, MAPK9, FYN, SOS1, PLA2G12A, PIK3CB, PLA2G3, SOS2, PIK3R2, AKT2, RAC3",0.183758700008217,0,FALSE +"H520","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.21642,-0.818,0.785,17280,0.881,"PLCG2, ARPC5, CFL1, VAV3, PLPP1, PRKCA, ARPC1B, VAV2, ASAP3, PLPP3, ARPC2, GSN, RAC2, PIK3CD, CDC42, PLD1, SPHK1, PRKCD, VASP",0.105130343254747,0.0550240915879521,FALSE +"H520","Input","KEGG_FOCAL_ADHESION",-0.34036,-1.16,0.242,15230,0.643,"PIK3R1, ACTN2, RELN, VWF, LAMC3, FLT4, PDGFRA, COL11A1, ITGA2, COL5A1, COL5A3, MYLK, ITGB5, THBS2, ITGA2B, COL6A3, ITGA11, CCND2, PRKCG, AKT3, COL6A2, PDGFC, ACTG1, VEGFB, ITGA4, COL3A1, PDGFRB, PDGFA, LAMA1, BCAR1, COL1A2, LAMC2, RAP1B, COL5A2, ITGAV, ITGB8, COL4A2, ITGB6, ITGB3, LAMA4, CCND3, LAMB2, VAV3, MET, COL6A1, PRKCA, DOCK1, COL1A1, FLNC, RAP1A, PGF, VAV2, LAMA3, VEGFC, SHC1, BIRC3, ITGA5, MYL12A, TNC, ILK, COL4A1, MYL9, RAC2, VCL, LAMA5, FLNA, PIK3CD, ITGB1, MYL12B, PARVA, CDC42, LAMB3, CAPN2, ACTB, ERBB2, CAV2, RHOA, EGFR, CAV1, ITGA3, PXN, FLNB, IGF1R, LAMB1, VASP, ZYX",0.616184634019569,0.191789027075778,FALSE +"H520","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.27945,-1,0.409,15141,0.775,"ALPG, ALPL, ALPP, QDPR, SPR, FPGS",0.388276691992658,0.11069829749369,FALSE +"H520","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.22115,-0.779,0.789,16567,0.901,"FPGT, PFKFB4, MTMR6, PFKL, PHPT1, GMPPA, PFKFB2, PFKP",0.10292299679058,0.045275209020937,FALSE +"H520","Input","KEGG_GALACTOSE_METABOLISM",-0.38693,-1.38,0.0941,17740,0.657,"GLB1, B4GALT1, GALK1, GALE, PFKP, PGM1",1.02641037657274,0.182434630440219,FALSE +"H520","Input","KEGG_GAP_JUNCTION",0.32333,0.898,0.627,3267,0.985,"HTR2C, TUBB2B, MAP2K5, ADCY7, ITPR1, MAP2K1, TUBB2A, MAP2K2, MAP3K2, GNA11, CDK1, RAF1, ADRB1, PRKG2, SOS1, PRKX, ADCY1, PRKACB",0.202732459169284,0.00656376950238827,FALSE +"H520","Input","KEGG_GLIOMA",0.31251,0.865,0.668,6125,1,"IGF1, MAP2K1, MAP2K2, PIK3CA, BRAF, RAF1, MTOR, SOS1, E2F2, PIK3CB, CALML5, CDKN2A, SOS2, PIK3R2, AKT2, E2F1, RB1, CAMK2G, TGFA, CDK6, CALML6, EGF, MAPK1, E2F3, CALML3, CAMK2A, CALM3, PIK3R3",0.175223537524454,0,FALSE +"H520","Input","KEGG_GLUTATHIONE_METABOLISM",0.24475,0.683,0.917,2025,1,"SMS, GPX2, GSTA4, GCLC, TXNDC12, IDH1",0.0376306643299789,0,FALSE +"H520","Input","KEGG_GLYCEROLIPID_METABOLISM",0.40483,1.14,0.268,2416,0.788,"AKR1A1, LIPC, LCLAT1, DGKQ, DGKG, ALDH2, AGPAT4, GK, ALDH9A1, LPL",0.571865205971211,0.103473782510445,FALSE +"H520","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.23019,-0.788,0.7,17148,0.903,"DGKH, LCAT, ACHE, AGPAT3, PISD, GPD2, PLPP1, LYPLA2, PCYT2, PLPP3, MBOAT7, AGPAT2, PLD1, DGKA, GPD1L",0.154901959985743,0.0443122496864942,FALSE +"H520","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.46351,1.29,0.138,2770,0.607,"PIPOX, PSPH, PHGDH, SHMT2, MAOB, CBS, CHDH, PSAT1",0.860120913598763,0.216811308924742,FALSE +"H520","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.22013,0.617,0.952,4876,1,"AKR1A1, PCK2, ALDH3A1, ALDH2, PDHA1, ALDH9A1, HK2, ADH5, ALDH3A2, DLAT, ENO3, ALDOB, ALDH7A1, ADH6",0.0213630516155257,0,FALSE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.23729,-0.813,0.67,16826,0.871,"XYLT1, CHST11, UST, CHST3, CHPF2",0.173925197299174,0.0599818449923368,FALSE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.26186,0.733,0.859,3513,1,"NDST2, B3GAT3, HS6ST1, GLCE, HS2ST1",0.0660068361687577,0,FALSE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.34902,-1.25,0.17,17016,0.7,"B3GNT7, ST3GAL1, B4GAT1, B3GNT2, FUT8, B4GALT1",0.769551078621726,0.154901959985743,FALSE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.28559,-0.993,0.419,12993,0.766,"NAGLU, HEXA, GUSB, HYAL4, SGSH, HYAL2, IDS, HGSNAT, HPSE, GLB1, HEXB, GNS, GALNS",0.377785977033705,0.115771230367396,FALSE +"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.51121,-1.94,0,16108,0.62,"ST3GAL5, ST8SIA1, ST3GAL1, GLB1, HEXB, ST6GALNAC4, ST6GALNAC6",Inf,0.207608310501746,FALSE +"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.30192,-1.11,0.278,16360,0.73,"ST8SIA1, B3GALT5, GBGT1, ST3GAL1, NAGA, HEXB",0.555955204081924,0.136677139879544,FALSE +"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.50207,1.4,0.0684,2431,0.526,"B3GALT2, FUT1, B4GALT2, ST3GAL3, FUT7, FUT4, FUT9",1.16494389827988,0.279014255846261,FALSE +"H520","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.50654,1.41,0.0675,5032,0.594,"PIGM, PIGX, PIGG, PIGQ, PIGH, PIGS, PIGA, PIGP, PIGN, PIGO, PGAP1, PIGV, PIGW",1.17069622716898,0.226213555018806,FALSE +"H520","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.61907,1.74,0.00899,4790,0.436,"HAO2, MTHFD2, PGP, MTHFD1L, AFMID, MTHFD2L, HYI, GRHPR",2.04624030826677,0.360513510731414,FALSE +"H520","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.26844,0.755,0.841,4479,1,"ADCY7, ITPR1, MAP2K1, ATF4, MAP2K7, MAP2K2, MAP3K4, MAP3K2, GNA11, MAP2K6, RAF1, MAPK9, SOS1, PLA2G12A, PRKX, ADCY1, PRKACB, CALML5, PLA2G3, SOS2, PLCB1, CAMK2G, MAP2K4",0.0752040042020878,0,FALSE +"H520","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.26891,0.761,0.821,438,1,"PRF1",0.0856568428805592,0,FALSE +"H520","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.34723,0.973,0.495,5660,0.912,"BMP8A, SHH, CSNK1G3, BMP8B, WNT11, CSNK1G2, PTCH2, BMP7, CSNK1G1, PRKX, PRKACB, GSK3B, BMP4, WNT8B, FBXW11, RAB23, PRKACA, WNT5A, PTCH1, STK36, CSNK1E",0.305394801066431,0.0400051616715838,FALSE +"H520","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.29731,-1.06,0.312,15170,0.721,"ITGA1, TNF, CD1D, CSF1R, ITGA2, ITGAM, FCGR1A, CD55, ITGA2B, CD22, CD36, IL1A, CSF2, ANPEP, ITGA4, IL7, CD9, IL1B, CSF2RA, CD37, IL7R, IL6, ITGB3, ITGA5, IL6R, CD59, CSF1, ITGA3, IL4R",0.505845405981557,0.142064735280571,FALSE +"H520","Input","KEGG_HISTIDINE_METABOLISM",0.43296,1.22,0.188,2218,0.666,"LCMT1, MAOB, ALDH3A1, ALDH2, ALDH9A1, LCMT2, CNDP1",0.72584215073632,0.176525770829699,FALSE +"H520","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.50465,1.41,0.0588,5713,0.594,"POLD3, MUS81, RAD51C, RAD54B, RAD51B, RAD51, EME1, RAD50, BLM, XRCC2, RAD54L, RAD52, MRE11, RPA4, XRCC3, BRCA2, POLD2, RPA2",1.23062267392386,0.226213555018806,FALSE +"H520","Input","KEGG_HUNTINGTONS_DISEASE",0.3802,1.06,0.361,5916,0.88,"UCP1, NDUFS5, SOD1, ITPR1, SLC25A4, POLR2D, AP2B1, NDUFS7, POLR2G, CREB1, NDUFB10, POLR2H, COX4I1, UQCR11, NRF1, SDHB, NDUFA2, SP1, TBP, VDAC2, TFAM, NDUFA10, VDAC1, POLR2C, CREBBP, ATP5F1D, DCTN4, NDUFA9, POLR2E, COX7C, COX7A2L, NDUFA7, SIN3A, SLC25A5, ATP5F1C, UQCRQ, PPID, AP2M1, NDUFA4L2, COX5A, NDUFAB1, NDUFC2, ATP5MC3, NDUFB6, POLR2J, PLCB1, NDUFB7, CREB3L4, UQCRC2, NDUFS6, POLR2K, NDUFA4, NDUFS3, REST, NDUFA1, UQCRHL, NDUFB9, CYC1, EP300, HDAC2, NDUFB1, NDUFC1, UQCRB, ATP5F1A, DNAH1, NDUFV1, NDUFB5, AP2A2, CREB3, DCTN1, POLR2I, HAP1, HIP1, TBPL1",0.442492798094342,0.0555173278498314,FALSE +"H520","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.34828,-1.27,0.144,14536,0.709,"ITGA7, SGCD, ITGA10, TNNT2, ACE, ITGA1, TNF, SGCA, TNNC1, CACNG7, DES, ITGA2, ITGB5, CACNA2D4, ITGA2B, ITGA11, CACNA1C, CACNG6, ACTG1, CACNG4, ITGA4, CACNG8, ITGAV, ITGB8, IL6, ITGB6, ITGB3, TNNI3, CACNA2D1, TGFB3, TPM1, ITGA5, LMNA, DAG1, ITGB1, TGFB1, TPM2, ACTB, ITGA3, CACNB3, PRKAG2",0.84163750790475,0.149353764816933,FALSE +"H520","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.29103,0.818,0.762,5884,1,"PIP4K2B, MIOX, PIK3CA, OCRL, INPPL1, PIK3CB, PIKFYVE, PIK3C3, CDIPT, INPP5J, PLCD4, PIK3C2A, ITPKB, PLCB1, ALDH6A1, IMPA1, PIK3C2B, PI4KB, PIP5K1A, INPP5B, PIP5K1C, INPP5E, IPMK, INPP4A",0.1180450286604,0,FALSE +"H520","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.36694,1.02,0.418,4093,0.844,"EIF4EBP1, PHKB, PPP1R3B, MKNK2, MAP2K1, MAP2K2, SOCS4, SORBS1, PCK2, TSC2, PYGM, PIK3CA, PPP1CC, PDPK1, FLOT2, ACACA, BRAF, PHKA2, EIF4E, RAF1, MAPK9, MTOR, PHKA1, CBL, SOS1, EIF4E2, PIK3CB, PRKX, PRKAG1, HK2, PRKACB, RPS6KB2, PDE3B, CALML5, RPS6, SOCS1, PPP1CB, GSK3B, SOS2, PIK3R2, AKT2, PRKAB2, PHKG2",0.378823718224965,0.073657553374345,FALSE +"H520","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.33611,0.929,0.578,597,0.946,"CCL27, MADCAM1, CXCR4",0.238072161579471,0.0241088635982073,FALSE +"H520","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.20307,-0.712,0.926,16023,0.896,"IL13RA2, CCND2, AKT3, IL15, STAM2, CSF2, JAK3, CBLC, LEPR, IFNAR2, IL7, CSF2RA, SOCS2, STAT4, IL7R, IL6, CCND3, IFNGR1, STAT5A, STAM, CTF1, IL12A, PIAS3, JAK1, SPRY1, STAT5B, CISH, PIK3CD, IL6R, OSMR, LIF, IL6ST, CLCF1, SOCS3, IL4R, STAT6",0.0333890133180656,0.0476919903378748,FALSE +"H520","Input","KEGG_LEISHMANIA_INFECTION",-0.36403,-1.35,0.0816,15651,0.646,"ITGAM, STAT1, NFKBIA, FCGR1A, FOS, FCGR2A, IL1A, ITGA4, TLR4, NCF2, IL1B, PTGS2, ITGB2, IFNGR1, MAPK11, TGFB3, C3, IL12A, JAK1, ITGB1, TGFB1",1.08830984124614,0.189767482004916,FALSE +"H520","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.35323,-1.3,0.155,14879,0.697,"CLDN4, CLDN14, ACTN1, CDH5, VCAM1, CLDN22, PIK3R1, ACTN2, MMP9, CYBB, JAM2, CLDN16, CXCL12, ITGAM, EZR, PRKCG, ESAM, ACTG1, ITGA4, BCAR1, NCF2, THY1, RAPGEF3, RAP1B, CLDN9, ITGB2, PLCG2, RASSF5, SIPA1, VAV3, PRKCA, MAPK11, PTK2B, RAP1A, VAV2, MYL12A, MYL9, RAC2, VCL, CLDN1, ICAM1, PIK3CD, ITGB1, MYL12B, CDC42, ACTB, RHOA, PXN, VASP, CD99",0.809668301829709,0.156767221901991,FALSE +"H520","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.63758,1.78,0.00887,5612,0.512,"ALDH2, ALDH9A1, HADHA, ALDH3A2, ALDH7A1, EHHADH, YOD1, NAA80",2.05207638016827,0.290730039024169,FALSE +"H520","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.16716,0.47,0.998,14427,1,"PLA2G12A, PLA2G3, CYP3A4, PLA2G6, CYP3A7, PLA2G4B, PLA2G4E, CYP2J2, PLA2G10, PLA2G4A, CYP2C9, PLA2G2E, PLA2G2D, PLA2G2A, CYP2C18, PLA2G12B, CYP1A2, CYP3A43, PLA2G5, PLA2G2C, PLA2G2F, CYP3A5, CYP2C19, ALOX15, CYP2C8, PLA2G1B, AKR1B10",0.000869458712628891,0,FALSE +"H520","Input","KEGG_LONG_TERM_DEPRESSION",0.38407,1.09,0.325,2535,0.892,"IGF1, ITPR1, PPP2CA, MAP2K1, MAP2K2, BRAF, GNA11, RAF1, PRKG2, PPP2R1B, PLA2G12A",0.488116639021126,0.0496351456238769,FALSE +"H520","Input","KEGG_LONG_TERM_POTENTIATION",0.34937,0.962,0.511,6008,0.897,"ITPR1, MAP2K1, ATF4, MAP2K2, RPS6KA6, PPP1CC, BRAF, RAF1, CREBBP, PPP3R1, RPS6KA2, PRKX, ADCY1, PRKACB, CALML5, PPP1CB, PLCB1, CAMK2G, PRKACA, CALML6, EP300, MAPK1, CALML3, CAMK2A, CALM3",0.291579099865287,0.0472075569559079,FALSE +"H520","Input","KEGG_LYSINE_DEGRADATION",0.54166,1.49,0.048,6899,0.608,"PIPOX, NSD3, KMT5A, NSD2, DOT1L, NSD1, ALDH2, SETD1A, ALDH9A1, HADH, HADHA, SETDB1, SETD1B, ALDH3A2, SUV39H2, ALDH7A1, DLST, EHHADH, KMT5C, ASH1L, ACAT1, SETDB2, AASDH, GCDH, KMT5B, PLOD3, EHMT2, ECHS1, EHMT1, SUV39H1",1.31875876262441,0.216096420727265,FALSE +"H520","Input","KEGG_LYSOSOME",-0.3038,-1.09,0.315,16611,0.707,"NAGPA, AP3B1, PLA2G15, LAMP1, SUMF1, ACP5, SLC11A1, M6PR, AP1S3, LAPTM4A, CLN5, GM2A, CTSV, NAGA, SMPD1, CTSL, LGMN, GLB1, HEXB, GNS, CTSS, CTSH, TPP1, NEU1, GALNS, FUCA1, NPC2, AP1S1, ABCA2, CTSB, CTSD, CD68, CD63, CLTCL1, CTSA, LIPA, TCIRG1",0.501689446210399,0.150580586203101,FALSE +"H520","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.30889,0.858,0.678,3881,1,"CACNA1E, FGF3, FGF19, FGF4, FGF21, CACNA2D3, MAP2K5, FGF20, TAOK1, GADD45G, PAK2, FGF9, PAK1, MKNK2, MAP2K1, FGFR1, NLK, ATF4, MAP2K7, MAP2K2, MAP3K13, RPS6KA6, ATF2, TGFB2, BRAF, MAP3K4, MAP3K2, DUSP16, MAPKAPK5, MAP2K6, RAF1, MAPK8IP3, MAPK9, IL1R2, ECSIT, SOS1, MAP3K7, FGFR3, PLA2G12A, DUSP14, DUSP6, PPP3R1, MAP4K3, NF1, RPS6KA2, PRKX, CACNA1B, PRKACB, FGF22, FGF13, TAOK2, PLA2G3, MAP4K1, HSPA1L, MAP4K2, SOS2, AKT2",0.168770306132937,0,FALSE +"H520","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.38264,1.06,0.371,445,0.88,"FOXA2, ONECUT1",0.430626090384954,0.0555173278498314,FALSE +"H520","Input","KEGG_MELANOGENESIS",0.36435,1,0.459,6351,0.869,"KITLG, DVL3, TCF7, ADCY7, FZD1, MAP2K1, MAP2K2, LEF1, WNT11, CREB1, TCF7L2, MC1R, RAF1, FZD3, CREBBP, DCT, CTNNB1, PRKX, ADCY1, PRKACB, FZD10, CALML5, GSK3B, WNT8B, PLCB1, CAMK2G, GNAI1, CREB3L4, PRKACA, WNT5A, CALML6, EP300, MAPK1, CALML3, CREB3, CAMK2A, CALM3, FZD8, FZD6, WNT16, WNT2B, DVL1",0.338187314462739,0.0609802235513335,FALSE +"H520","Input","KEGG_MELANOMA",0.48653,1.34,0.101,3954,0.593,"FGF3, FGF19, FGF4, IGF1, FGF21, FGF20, FGF9, MAP2K1, FGFR1, MAP2K2, PIK3CA, BRAF, RAF1, E2F2, PIK3CB, FGF22, FGF13, CDKN2A, PIK3R2, AKT2, E2F1",0.995678626217357,0.226945306635737,FALSE +"H520","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.23149,0.644,0.942,3224,1,"UGT2A1, AKR1C1, AKR1C2, ALDH3A1, GSTA4, AKR1C3, CYP1A1, EPHX1, ADH5",0.0259490972071227,0,FALSE +"H520","Input","KEGG_MISMATCH_REPAIR",0.37097,1.02,0.419,7112,0.844,"RFC4, POLD3, EXO1, RFC1, PMS2, RFC5, RPA4, MSH6, POLD2, RPA2, RFC3, RPA3, MSH2, RFC2",0.377785977033705,0.073657553374345,FALSE +"H520","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.53531,1.49,0.043,3881,0.608,"IGF1, EIF4EBP1, RPS6KA6, TSC2, PIK3CA, PDPK1, BRAF, STK11, MLST8, EIF4E, ULK1, MTOR, DDIT4, EIF4E2, PIK3CB, ULK3, RPS6KA2, VEGFA, RPS6KB2, RPS6, PIK3R2, EIF4B, AKT2",1.36653154442041,0.216096420727265,FALSE +"H520","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.25675,0.715,0.882,2852,1,"IFNA5, SYK, PRF1, PAK1, NFATC3, MAP2K1, ULBP1, MAP2K2, PIK3CA, PTPN11, BRAF, IFNAR1, RAF1, FYN, SOS1, PPP3R1, PIK3CB",0.0545314148681803,0,FALSE +"H520","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.39605,1.11,0.299,2107,0.857,"GPR50, GRM8, GRIK3, GPR83, GRM3, NMUR2, CHRM3, OPRD1, GABRA3, PTH2R, ADRA2C, HTR2C, GABRR2, LPAR6, SCTR, GABRG2, MCHR2, GABRR1, CHRNA7, P2RY11, GALR2, PTGER4, GABRQ, GALR3, LTB4R2, MC1R, LTB4R, P2RY14, ADRB1",0.52432881167557,0.0670191780768018,FALSE +"H520","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.21165,0.591,0.972,5375,1,"MAP2K5, SH2B1, MAP2K1, ATF4, MAP2K7, MAP2K2, RPS6KA6, PIK3CA, PTPN11, PDPK1, BRAF, RAF1, MAPK9, SOS1, PIK3CB, RPS6KA2, RIPK2, NFKBIB, CALML5, GSK3B, SOS2, PIK3R2, AKT2, CAMK2G, PRDM4, IRAK1, CRKL, NTRK2, BEX3, FASLG, CALML6, TP73, PSEN1, MAPK1",0.0123337350737254,0,FALSE +"H520","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.27808,-0.955,0.419,15820,0.732,"NT5M, PNP, BST1, NAMPT, NT5C2, AOX1, ENPP1, QPRT, NMNAT2, NNMT, NT5E",0.377785977033705,0.135488918941608,FALSE +"H520","Input","KEGG_NITROGEN_METABOLISM",0.56754,1.57,0.0294,1340,0.652,"CA6, CA7, GLUD2, CA8, ASNS",1.53165266958784,0.18575240426808,FALSE +"H520","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.29362,-1.02,0.462,16189,0.787,"NLRP3, NOD1, IKBKB, CCL5, IL1B, TNFAIP3, TAB3, IL6, CXCL1, MAPK11, CXCL2, CASP1, CXCL8, BIRC3, CARD6, IL18, NLRP1, TRIP6",0.335358024443874,0.104025267640935,FALSE +"H520","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.46733,1.31,0.116,7316,0.59,"XRCC5, RAD50, POLL, DNTT, MRE11, FEN1, LIG4, DCLRE1C, NHEJ1, XRCC6",0.935542010773082,0.229147988357856,FALSE +"H520","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.26708,0.75,0.838,5613,1,"MAP2K1, MAP2K2, PIK3CA, PDPK1, BRAF, RAF1, SOS1, E2F2, PIK3CB, CDKN2A, SOS2, PIK3R2, AKT2, E2F1, RB1, TGFA, CDK6, EGF, MAPK1, E2F3",0.0767559813697235,0,FALSE +"H520","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.37491,1.05,0.375,5494,0.854,"DVL3, MAML1, MAML2, CTBP1, LFNG, CREBBP, CIR1, RFNG, APH1A, PSEN2, DTX3, MAML3, KAT2A, EP300, HDAC2, ADAM17, PSEN1, SNW1, CTBP2",0.425968732272281,0.068542129310995,FALSE +"H520","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.33699,0.917,0.606,5873,0.956,"RFC4, POLD3, ERCC4, RAD23A, GTF2H3, ERCC3, CUL4B, RFC1, CCNH, POLE, RFC5, RPA4, POLE4, XPC, DDB2, POLE3, POLD2, RPA2, DDB1, RFC3",0.217527375833714,0.0195421077238999,FALSE +"H520","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.38059,1.06,0.37,6489,0.88,"MGAT5, MAN1A1, MAN2A1, B4GALT2, ALG3, RPN1, ST6GAL1, MOGS, ALG9, ALG13, STT3B, MAN2A2, B4GALT3, RPN2, ALG1, GANAB, DOLPP1, ALG10B, MGAT4A, ALG5, ALG12, RFT1, MAN1C1, MGAT4B, STT3A",0.431798275933005,0.0555173278498314,FALSE +"H520","Input","KEGG_OLFACTORY_TRANSDUCTION",0.37001,1.04,0.407,1297,0.831,"OR10S1, OR6T1, OR4D5, OR2B3, OR6B2, OR5M11, OR10AD1, OR11H6, OR8S1, OR10AG1, OR13J1, GNAL, OR1J1",0.39040559077478,0.080398976215889,FALSE +"H520","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.56465,1.58,0.0174,6339,0.736,"MTHFD2, SHMT2, ALDH1L1, GART, MTHFD1L, MTHFD2L, MTHFR, MTFMT, FTCD, DHFR, MTHFS",1.7594507517174,0.133122185662501,FALSE +"H520","Input","KEGG_OOCYTE_MEIOSIS",0.41586,1.15,0.26,5042,0.807,"IGF1, ADCY7, ITPR1, PPP2CA, MAP2K1, CDC23, RPS6KA6, PPP1CC, ESPL1, CDC20, CCNB2, CDK1, PLK1, PPP2R1B, CDC25C, STAG3, PPP3R1, MAD2L1, PKMYT1, RPS6KA2, PRKX, ANAPC7, ADCY1, PRKACB, ANAPC1, PPP2R5E, CALML5, SGO1, PPP1CB, CDC27, BUB1, AR, MAD2L2, CAMK2G, FBXW11, PPP2R5D, SKP1, ANAPC11, PRKACA, CALML6",0.585026652029182,0.0931264652779296,FALSE +"H520","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.46682,-1.59,0.0392,17370,0.794,"MAN2B2, GLB1, HEXB, NEU1, FUCA1",1.40671393297954,0.100179497572904,FALSE +"H520","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.40796,1.15,0.266,5601,0.807,"ATP4A, NDUFS5, ATP6V0B, ATP5ME, ATP6V0A2, ATP6V1E2, NDUFS7, NDUFB10, PPA1, COX4I1, COX11, UQCR11, SDHB, NDUFA2, NDUFA10, ATP5F1D, NDUFA11, NDUFA9, COX7C, COX7A2L, NDUFA7, ATP6V1G2, ATP5F1C, ATP6V0C, UQCRQ, ATP6V1H, NDUFA4L2, COX5A, NDUFAB1, NDUFC2, ATP5MC3, NDUFB6, NDUFB7, UQCRC2, NDUFS6, NDUFA4, NDUFS3, NDUFA1, UQCRHL, NDUFB9, CYC1, ATP6V0E2, ATP6V0A1, NDUFB1, NDUFC1, UQCRB, ATP6V1A, ATP5F1A, NDUFV1, NDUFB5",0.575118363368933,0.0931264652779296,FALSE +"H520","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.38591,1.08,0.338,1096,0.911,"GALNT10, GALNT13, GCNT1, GALNT6",0.471083299722345,0.0404816230270017,FALSE +"H520","Input","KEGG_P53_SIGNALING_PATHWAY",0.29023,0.805,0.765,2571,1,"IGF1, GADD45G, SESN2, SIAH1, RPRM, COP1, TSC2, CCNB2, CDK1, TP53AIP1, CHEK1, CCNG1, ATM",0.116338564846382,0,FALSE +"H520","Input","KEGG_PANCREATIC_CANCER",-0.29123,-0.97,0.422,17729,0.719,"RALBP1, RALGDS, TGFB3, PGF, VEGFC, JAK1, RAC2, TP53, PIK3CD, CDC42, PLD1, TGFB1, ERBB2, EGFR, TGFBR2, RALB",0.374687549038326,0.143271109617117,FALSE +"H520","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.28974,0.807,0.769,6096,1,"PANK3, PPCDC, COASY, PPCS, PANK4, PANK1, PANK2",0.114073660198569,0,FALSE +"H520","Input","KEGG_PARKINSONS_DISEASE",0.40031,1.13,0.279,6850,0.805,"NDUFS5, SLC18A2, SLC25A4, NDUFS7, NDUFB10, COX4I1, UQCR11, SDHB, NDUFA2, VDAC2, NDUFA10, VDAC1, ATP5F1D, NDUFA9, COX7C, COX7A2L, NDUFA7, SLC25A5, ATP5F1C, UQCRQ, PPID, UCHL1, NDUFA4L2, UBE2J2, COX5A, NDUFAB1, NDUFC2, ATP5MC3, NDUFB6, NDUFB7, UQCRC2, PARK7, NDUFS6, NDUFA4, NDUFS3, NDUFA1, UQCRHL, NDUFB9, CYC1, NDUFB1, NDUFC1, UQCRB, ATP5F1A, NDUFV1, NDUFB5, UBE2J1, UBE2L6, PINK1, CASP9, UQCRFS1, COX8A, NDUFS1, NDUFA6, CASP3, COX6A1, SNCA, COX7B, ATP5MC2",0.554395796726402,0.0942041196321315,FALSE +"H520","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.32967,-1.16,0.238,16265,0.643,"TUBB8, ACTG1, TLR4, TUBB4B, TLR5, TUBB, ARPC5, PRKCA, ARPC1B, ARPC2, CLDN1, ITGB1, CDC42, TUBB6, ACTB, RHOA, TUBA4A",0.623423042943488,0.191789027075778,FALSE +"H520","Input","KEGG_PATHWAYS_IN_CANCER",0.28208,0.787,0.797,4222,1,"FGF3, FGF19, FGF4, IGF1, ZBTB16, FGF21, KITLG, CTNNA2, DVL3, AXIN2, TCF7, FGF20, SHH, FGF9, APC, FZD1, RUNX1, MAP2K1, FGFR1, DAPK2, MAP2K2, LEF1, VHL, WNT11, CTBP1, TCF7L2, LAMC1, PIK3CA, TGFB2, BRAF, RAF1, FZD3, PIAS4, MAPK9, CREBBP, PTCH2, MTOR, CTNNA1, EGLN2, CBL, SOS1, SMAD4, FGFR3, XIAP, EGLN1, E2F2, AXIN1, PIK3CB, CTNNB1, RAD51, ELOB, FH, VEGFA, SKP2, FGF22, TRAF4, SLC2A1, FZD10, FGF13, CKS1B, BIRC5, ARNT, ARNT2, CDKN2A, GSK3B, APPL1, SOS2, PIK3R2, AKT2, TPR, BMP4, E2F1, EPAS1, TGFBR1, WNT8B, AR, RAC3, RB1, PTK2",0.0985416786038876,0,FALSE +"H520","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.25667,0.718,0.865,2705,1,"UGT2A1, DCXR",0.0629838925351858,0,FALSE +"H520","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.323,-1.17,0.248,18666,0.743,"DERA, PFKP, PGM1",0.605548319173784,0.129011186239425,FALSE +"H520","Input","KEGG_PEROXISOME",0.35016,0.974,0.482,2893,0.921,"HAO2, PIPOX, PRDX1, SOD1, MPV17L, PEX12, PEX2, IDH1, PECR, SLC27A2, PEX14, PEX5, PEX11G, ABCD4, PEX16",0.31695296176115,0.0357403698031511,FALSE +"H520","Input","KEGG_PHENYLALANINE_METABOLISM",0.50311,1.4,0.075,1326,0.526,"PAH, GOT2, MAOB, ALDH3A1",1.1249387366083,0.279014255846261,FALSE +"H520","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.27782,0.782,0.81,6125,1,"DGKQ, ITPR1, PIP4K2B, DGKG, PIK3CA, OCRL, INPPL1, PIK3CB, PIKFYVE, PIK3C3, CDIPT, CALML5, INPP5J, PLCD4, PIK3C2A, PIK3R2, ITPKB, PLCB1, IMPA1, DGKE, PIK3C2B, PI4KB, CALML6, PIP5K1A, INPP5B, CDS1, PIP5K1C, CALML3, INPP5E, INPP4A, CALM3, PIK3R3",0.0915149811213502,0,FALSE +"H520","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.40398,1.14,0.273,2577,0.788,"UROD, UGT2A1, EARS2, FECH, HMBS",0.563837352959244,0.103473782510445,FALSE +"H520","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.32613,0.902,0.613,3610,0.985,"ADIPOQ, UCP1, SORBS1, PCK2, PDPK1, GK, ME1, LPL, SLC27A2, FADS2, NR1H3, SLC27A5",0.212539525481585,0.00656376950238827,FALSE +"H520","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.27586,-1,0.382,17295,0.775,"ACOX2, CYP39A1, SCP2",0.417936637088291,0.11069829749369,FALSE +"H520","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.19981,0.554,0.981,4361,1,"RFXAP, TNFRSF13C, RAG1, RFX5, IGLL1, CD8A",0.0083309926200515,0,FALSE +"H520","Input","KEGG_PRION_DISEASES",0.35537,1,0.467,5375,0.869,"SOD1, MAP2K1, MAP2K2, LAMC1, FYN, PRKX, PRKACB, NCAM1, STIP1, PRKACA, MAPK1",0.330683119433888,0.0609802235513335,FALSE +"H520","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.43344,1.22,0.181,4986,0.666,"IGF1, ADCY7, MAP2K1, CDC23, FZR1, RPS6KA6, PIK3CA, BRAF, CCNB2, CDK1, RAF1, PLK1, MAPK9, CDC25C, MAD2L1, PKMYT1, PIK3CB, RPS6KA2, PRKX, ANAPC7, ADCY1, PRKACB, ANAPC1, PDE3B, PIK3R2, AKT2, CDC27, BUB1, MAD2L2, GNAI1, ANAPC11, PRKACA, CCNA2",0.742321425130815,0.176525770829699,FALSE +"H520","Input","KEGG_PROPANOATE_METABOLISM",0.44919,1.25,0.152,5901,0.688,"ACSS3, ALDH2, ACACA, ALDH9A1, HADHA, HIBCH, ALDH3A2, ACACB, ALDH6A1, ALDH7A1, PCCB, EHHADH, MLYCD, SUCLA2, SUCLG1, MCEE, ACAT1",0.818156412055227,0.162411561764489,FALSE +"H520","Input","KEGG_PROSTATE_CANCER",0.3433,0.965,0.501,4584,0.911,"IGF1, TCF7, MAP2K1, FGFR1, ATF4, MAP2K2, LEF1, CREB1, TCF7L2, PIK3CA, PDPK1, BRAF, RAF1, CREBBP, MTOR, SOS1, E2F2, PIK3CB, CTNNB1, GSK3B, SOS2, PIK3R2, AKT2, E2F1, AR, RB1, CREB3L4, TGFA",0.300162274132754,0.0404816230270017,FALSE +"H520","Input","KEGG_PROTEASOME",0.28788,0.794,0.796,7640,1,"PSMD7, PSMD2, PSMB11, PSMD11, PSMD14, PSME4, PSMC3, PSME3, PSMD8, PSMA3, PSMA4, PSMD1, PSMC5, PSMB1, PSME2, PSMC6, PSMD3, PSMD6, PSMD4, PSMA2, PSMC2, PSMC1",0.0990869322623309,0,FALSE +"H520","Input","KEGG_PROTEIN_EXPORT",0.46945,1.34,0.11,3508,0.593,"SRPRB, IMMP1L, SRP19, SEC63, SEC61A1, SEC11A, SRP9, SEC62, SEC11C",0.958607314841775,0.226945306635737,FALSE +"H520","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.37818,1.04,0.411,1596,0.831,"GLUD2, PCK2, SLC25A10",0.386158178123931,0.080398976215889,FALSE +"H520","Input","KEGG_PURINE_METABOLISM",0.34935,0.968,0.509,4730,0.915,"PDE8B, ENTPD8, ENTPD3, ENTPD1, PDE6B, ADCY7, PAPSS1, POLR2D, ALLC, GMPS, POLR3A, POLR2G, PDE4D, POLA1, POLD3, PDE5A, POLR2H, GART, NUDT2, PDE7A, POLR2C, POLR2E, RRM1, PRUNE1, PRPS2, ADCY1, NPR2, PDE3B, PPAT, POLR1E, POLR3G, GMPR, NME2, PAICS, NT5C3A, POLR2J, APRT, POLR1D, PDE11A, PRPS1, ADK, POLE, NT5C, POLR2K",0.293282217663241,0.0385789059335517,FALSE +"H520","Input","KEGG_PYRIMIDINE_METABOLISM",0.32743,0.918,0.594,4135,0.965,"ENTPD8, ENTPD3, ENTPD1, UCK2, POLR2D, POLR3A, POLR2G, DUT, POLA1, POLD3, POLR2H, CTPS1, NUDT2, CTPS2, POLR2C, DTYMK, POLR2E, RRM1, CAD, DHODH, UMPS, POLR1E, UCK1, POLR3G, NME2, NT5C3A, POLR2J, POLR1D",0.226213555018806,0.0154726866562074,FALSE +"H520","Input","KEGG_PYRUVATE_METABOLISM",0.37537,1.05,0.362,4790,0.854,"PCK2, ALDH2, PDHA1, ACACA, HAGH, ACYP1, ALDH9A1, ME1, ALDH3A2, DLAT, ACACB, ALDH7A1, GRHPR",0.441291429466834,0.068542129310995,FALSE +"H520","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.2637,0.74,0.859,3904,1,"FGF3, FGF19, FGF4, CHRM3, FGF21, FGF20, PAK2, FGF9, APC, PAK1, PIP4K2B, MAP2K1, FGFR1, MYL5, MAP2K2, MYLK2, PIK3CA, PPP1CC, BRAF, RAF1, IQGAP3, SOS1, FGFR3, CYFIP2, GIT1, TIAM1, PIK3CB, PFN2, PIKFYVE, WAS, FGF22, FGF13, ACTN4, NCKAP1, CYFIP1, PPP1CB, SOS2, PIK3R2, DIAPH1",0.0660068361687577,0,FALSE +"H520","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.47332,1.32,0.109,3806,0.605,"IFNA5, ATG4D, ULK1, GABARAPL2, ATG4B, ULK3, PIK3C3, ATG12, IFNA21",0.962573502059376,0.218244625347531,FALSE +"H520","Input","KEGG_RENAL_CELL_CARCINOMA",0.36288,1.02,0.417,4593,0.844,"PAK2, PAK1, MAP2K1, MAP2K2, VHL, PIK3CA, PTPN11, TGFB2, BRAF, RAF1, CREBBP, EGLN2, SOS1, EGLN1, PIK3CB, ELOB, FH, VEGFA, SLC2A1, ARNT, ARNT2, SOS2, PIK3R2, AKT2, EPAS1, VEGFD, TGFA, CRKL",0.379863945026242,0.073657553374345,FALSE +"H520","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.28008,0.777,0.814,4171,1,"THOP1, CMA1, NLN, MME",0.0893755951107988,0,FALSE +"H520","Input","KEGG_RETINOL_METABOLISM",0.3055,0.853,0.702,4876,1,"UGT2A1, RDH11, CYP1A1, RDH12, ALDH1A1, ADH5, PNPLA4, CYP3A4, DHRS4, DHRS4L2, ALDH1A2, ADH6",0.153662887870195,0,FALSE +"H520","Input","KEGG_RIBOFLAVIN_METABOLISM",0.50449,1.4,0.0801,2284,0.526,"MTMR2, RFK, ACP1, ACP4",1.09636748391576,0.279014255846261,FALSE +"H520","Input","KEGG_RIBOSOME",0.18726,0.524,0.988,5341,1,"RPS8, RPS28, RSL24D1, RPL22, RPL35A, MRPL13, RPLP0, RPL23A, RPS15, RPS6, RPL36, RPS2, RPS24, RPL18A, RPL4, RPS15A, RPL17, RPL26L1, FAU, RPLP1",0.00524305541237188,0,FALSE +"H520","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.20526,-0.743,0.831,17783,0.886,"MAPK11, CXCL8, IL12A, IRF3, TBK1, CASP10, TRADD, TBKBP1, IKBKE",0.080398976215889,0.0525662781129492,FALSE +"H520","Input","KEGG_RNA_DEGRADATION",0.54896,1.52,0.0344,4748,0.647,"CNOT1, EXOSC6, CNOT8, LSM1, CNOT6, DCP2, HSPA9, PAPOLG, EDC4, CNOT9, LSM7, EXOSC3, DCP1A, PARN, LSM3, EXOSC8, HSPD1, DCPS, DDX6, LSM4, XRN1, TENT4A, EDC3, CNOT7, CNOT6L, TTC37, EXOSC1, ENO3, EXOSC5, ZCCHC7",1.46344155742847,0.1890957193313,FALSE +"H520","Input","KEGG_RNA_POLYMERASE",0.41161,1.14,0.242,4730,0.788,"POLR2D, POLR3A, POLR2G, POLR2H, POLR2C, POLR2E, POLR1E, POLR3G, POLR2J, POLR1D, POLR2K",0.616184634019569,0.103473782510445,FALSE +"H520","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.51987,1.46,0.063,2788,0.602,"LCMT1, PAPSS1, CBS, MAT2A, SEPHS2, MAT2B, LCMT2, SEPHS1, SCLY",1.20065945054642,0.220403508742175,FALSE +"H520","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.28067,-0.985,0.383,15230,0.734,"PIK3R1, LAMC3, TRAF3, ITGA2, NFKBIA, ITGA2B, CCNE1, AKT3, IKBKB, MAX, LAMA1, LAMC2, PTGS2, ITGAV, COL4A2, TRAF5, LAMA4, LAMB2, RXRA, LAMA3, BIRC3, PIAS3, COL4A1, TP53, LAMA5, PIK3CD, ITGB1, LAMB3, ITGA3, LAMB1",0.416801226031377,0.134303940083929,FALSE +"H520","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.37511,1.05,0.353,3953,0.854,"GOSR1, STX5, SEC22B, USE1, TSNARE1, VAMP1, STX6, SNAP47, VAMP2, STX10, BNIP1, STX17",0.452225294612177,0.068542129310995,FALSE +"H520","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.3388,-1.21,0.13,17158,0.745,"SPTLC1, SGMS1, PLPP1, SMPD1, GLB1, PLPP3, SGMS2, NEU1, UGCG, SPHK1, SMPD2",0.886056647693163,0.127843727251707,FALSE +"H520","Input","KEGG_SPLICEOSOME",0.46757,1.3,0.135,5966,0.597,"PPIE, TRA2B, CTNNBL1, RBM17, ISY1, XAB2, PPIH, THOC3, SF3A2, LSM7, NCBP2, SNRPA, DHX8, SRSF5, HNRNPA1L2, LSM3, HNRNPM, SLU7, HNRNPU, HNRNPA1, USP39, RBMX, RBM22, SRSF3, SRSF10, SF3B1, THOC1, ZMAT2, DDX5, LSM4, BUD31, SRSF9, DHX38, TXNL4A, PRPF40A, U2SURP, DDX46, HSPA1L, THOC2, SRSF1, SMNDC1, AQR, CDC40, ALYREF, CHERP, SNRPF, SNRNP200, PRPF40B, HNRNPA3, SRSF8, SNRPG, SRSF2, PRPF3, DHX16, SART1, RBM8A, SNW1, MAGOHB, SRSF7, BCAS2, SF3A1, DDX42, SNRPD1, PLRG1, LSM5, HNRNPK, TCERG1, SNRPA1",0.869666231504994,0.224025668870631,FALSE +"H520","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.23507,-0.881,0.562,16846,0.797,"UGDH, GYS1, ENPP1, UXS1, AMY2B, PYGB, PGM1",0.250263684430939,0.0985416786038876,FALSE +"H520","Input","KEGG_STEROID_BIOSYNTHESIS",-0.39516,-1.47,0.0319,16365,0.762,"SQLE, DHCR24, MSMO1, LIPA",1.49620931694282,0.1180450286604,FALSE +"H520","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38192,1.07,0.335,4734,0.91,"UGT2A1, AKR1C1, AKR1C2, SRD5A3, AKR1C3, CYP1A1, HSD17B12, CYP3A4, SRD5A1, HSD11B2, AKR1C4, HSD17B8, SULT1E1",0.474955192963155,0.0409586076789064,FALSE +"H520","Input","KEGG_SULFUR_METABOLISM",0.42826,1.21,0.195,5228,0.679,"PAPSS1, SUOX, SULT1A3, BPNT1, SULT1E1, SULT1A4, SULT1A1",0.709965388637482,0.168130225719498,FALSE +"H520","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.38175,-1.41,0.143,13039,0.67,"IL10, FCGR2B, FCGR2C, GRIN2A, C1R, C6, C4B, C2, GRIN2B, C7, SNRPB, ACTN1, TNF, ACTN2, C4A, FCGR1A, ELANE, C1S, TRIM21, FCGR2A, CD40, C3",0.844663962534938,0.173925197299174,FALSE +"H520","Input","KEGG_TASTE_TRANSDUCTION",0.20059,0.564,0.983,5077,1,"GNB1, SCNN1A, PRKX, CACNA1B, PRKACB, TAS1R3, GNB3, GNG3, PRKACA, TAS2R46, TAS2R14",0.00744648216786438,0,FALSE +"H520","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.53476,1.48,0.0465,2943,0.585,"ADO, CSAD, GAD1",1.33254704711005,0.23284413391782,FALSE +"H520","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.25099,-0.93,0.533,4793,0.748,"GGPS1, ACAT1, ACAT2, PDSS1, MVD, IDI2, FDPS, PMVK, DHDDS, HMGCS1, MVK, HMGCR, HMGCS2, IDI1, PDSS2",0.273272790973428,0.126098402135539,FALSE +"H520","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.3788,1.06,0.356,6086,0.88,"BMP8A, NODAL, INHBE, INHBC, PPP2CA, AMH, BMP8B, ID4, SP1, TGFB2, THBS4, SMAD9, SMAD5, CREBBP, BMP7, SMAD4, PPP2R1B, SMAD1, INHBB, RBL1, ID3, RPS6KB2, E2F4, RBL2, BMP4, TGFBR1, SKP1, SMAD2, SMAD6, EP300, BMPR1A, MAPK1, SMAD7, MYC, BMPR2, ROCK2, CDKN2B, ACVR2B, RPS6KB1",0.448550002027125,0.0555173278498314,FALSE +"H520","Input","KEGG_THYROID_CANCER",0.43985,1.22,0.194,1729,0.666,"TCF7, MAP2K1, MAP2K2, LEF1, TCF7L2, BRAF",0.712198270069774,0.176525770829699,FALSE +"H520","Input","KEGG_TIGHT_JUNCTION",0.23182,0.645,0.935,4500,1,"MYH7B, CTNNA2, PRKCQ, PPP2CA, CSNK2A2, MYL5, RAB3B, MYH11, PPP2R2C, EPB41L3, PATJ, CTNNA1, PPP2R1B, CTNNB1, CRB3, ACTN4, PARD6A, MAGI1, LLGL2, F11R, AKT2, CLDN7, AFDN, PRKCZ, GNAI1, TJAP1, MYH3",0.0291883891274822,0,FALSE +"H520","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.18983,0.539,0.992,4567,1,"IFNA5, MAP2K1, MAP2K7, MAP2K2, PIK3CA, MAP2K6, IFNAR1, MAPK9, MAP3K7, PIK3CB, SPP1, TIRAP, IFNA21, PIK3R2, AKT2, TAB1, MAP2K4, IRAK1",0.00348832784582135,0,FALSE +"H520","Input","KEGG_TRYPTOPHAN_METABOLISM",0.35087,0.982,0.463,2805,0.909,"MAOB, WARS2, ALDH2, ALDH9A1, CYP1A1, HADH, HADHA, AFMID",0.334419008982047,0.0414361167780325,FALSE +"H520","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.43421,1.23,0.174,3844,0.735,"CACNA1E, ADIPOQ, SOCS4, PIK3CA, MAPK9, MTOR, PIK3CB, KCNJ11, CACNA1B, HK2, ABCC8, SOCS1, PIK3R2",0.7594507517174,0.133712660915805,FALSE +"H520","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.30032,0.84,0.737,4971,1,"PRF1, ICA1, HSPD1, GAD1, LTA, CPE, FASLG",0.132532512140949,0,FALSE +"H520","Input","KEGG_TYROSINE_METABOLISM",0.33098,0.929,0.584,3224,0.946,"LCMT1, GOT2, MAOB, DBH, ALDH3A1, LCMT2, DCT, ADH5",0.233587152887601,0.0241088635982073,FALSE +"H520","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.34281,0.959,0.53,4425,0.894,"CTLA4, MALT1, PAK2, PAK1, PRKCQ, NFATC3, MAP2K1, MAP2K7, MAP2K2, PIK3CA, PDPK1, RAF1, MAPK9, FYN, CBL, SOS1, MAP3K7, PPP3R1, PIK3CB, NFKBIB, NCK1, GSK3B, SOS2, PIK3R2, AKT2, PTPN6, CD8A, DLG1",0.275724130399211,0.0486624812040823,FALSE +"H520","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.43433,1.22,0.182,5850,0.666,"UBE2NL, UBE2D2, UBE2QL1, CDC34, KEAP1, UBE2R2, UBE2I, UBE2B, SIAH1, CDC23, FZR1, WWP1, VHL, COP1, CDC20, MGRN1, CUL5, PIAS4, CBL, UBE3A, XIAP, UBE2N, WWP2, CUL3, UBA2, CUL4B, ELOB, ANAPC7, SYVN1, HERC2, HERC1, KLHL9, SKP2, ANAPC1, UBE2Q1, SOCS1, UBE2J2, UBE2A, CDC27, STUB1, FANCL, UBE4B, FBXW11, RNF7, PIAS2, UBE2D3, SKP1, UBE2W, TRIM37, UBE2K, FBXW7, UBR5, ANAPC11, UBE2S, UBE4A, UBE2O, DDB2, PIAS1, BIRC6, MID1, TRIP12, BRCA1, UBE2J1, DDB1, UBE2M, FBXW8",0.739928612014925,0.176525770829699,FALSE +"H520","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.47841,1.33,0.114,7811,0.6,"PDHA1, LARS2, IARS2, BCAT2, BCAT1, VARS2",0.943095148663527,0.221848749616356,FALSE +"H520","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.37206,1.03,0.396,6698,0.85,"OXCT2, ACAA2, ALDH2, ALDH9A1, HADH, HADHA, HIBCH, BCKDHA, ALDH3A2, IVD, ACAD8, ALDH6A1, DBT, MCCC2, MCCC1, ALDH7A1, ACADSB, PCCB, EHHADH, MCEE, ACAT1, BCKDHB, HSD17B10, OXCT1, ECHS1",0.402304814074488,0.0705810742857073,FALSE +"H520","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.24862,0.696,0.9,3711,1,"ADCY7, ITPR1, PRKCQ, MAP2K1, MAP2K2, MYLK2, MYH11, PPP1CC, BRAF, GNA11, RAF1, KCNMA1, PLA2G12A, PRKX, ARHGEF11, KCNMB3, ADCY1, NPR2, PRKACB, CALML5, PLA2G3, PPP1CB",0.0457574905606751,0,FALSE +"H520","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.34212,0.962,0.518,5771,0.897,"DYNC1I1, DYNC1LI2, RAB11B, DCTN5, CREB1, DCTN4, PRKX, VAMP2, PRKACB, RAB11A, CREB3L4, DYNLL2, PRKACA, DYNC1H1, RAB5A, CREB3, DCTN1",0.285670240254767,0.0472075569559079,FALSE +"H520","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.21206,-0.753,0.856,16861,0.889,"SH2D2A, PTGS2, NOS3, NFATC2, PLCG2, PRKCA, MAPK11, NFATC1, RAC2, PIK3CD, CDC42, HSPB1, SPHK1, PXN",0.0675262353228468,0.0510982390297863,FALSE +"H520","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.25291,-0.895,0.566,17236,0.786,"ATP6V1E1, PDIA4, PLCG2, ERO1A, GNAS, ATP6V1B1, PRKCA, ATP6V1G1, ADCY9, ATP6V1F, ACTB, KDELR3, TCIRG1",0.247183568811729,0.104577453960592,FALSE +"H520","Input","KEGG_VIRAL_MYOCARDITIS",0.24931,0.695,0.901,2208,1,"MYH7B, PRF1, MYH11, SGCG, FYN",0.045275209020937,0,FALSE +"H520","Input","KEGG_WNT_SIGNALING_PATHWAY",0.37476,1.04,0.37,6720,0.831,"NKD1, WIF1, DKK2, DVL3, TBL1XR1, AXIN2, TCF7, SENP2, APC, PPP2CA, CSNK2A2, SIAH1, NFATC3, FZD1, NLK, TBL1X, LEF1, WNT11, CTBP1, TCF7L2, FZD3, MAPK9, CREBBP, SMAD4, MAP3K7, LRP6, PPP2R1B, NKD2, PPP3R1, AXIN1, CACYBP, CTNNB1, PRKX, RUVBL1, PRKACB, PPP2R5E, FZD10, GSK3B, WNT8B, RAC3, PLCB1, CAMK2G, FBXW11, PPP2R5D, SKP1, FRAT2, LRP5, SMAD2, CSNK2A1, PRKACA, WNT5A, PPARD, EP300, FRAT1, PSEN1, SFRP5, CTBP2, MYC, CSNK1E, ROCK2, CAMK2A, VANGL1, PPP2R5C, FZD8, FZD6, PPP2R5A, WNT16, WNT2B, DVL1, JUN, NFATC4, DVL2, NFAT5, CHD8, MAPK8, WNT6",0.431798275933005,0.080398976215889,FALSE +"H460","Input","KEGG_ABC_TRANSPORTERS",0.42084,1.57,0.0356,3238,0.189,"ABCC9, ABCB10, ABCC2, ABCA8, ABCG2, ABCB6, ABCB7, TAP2, ABCB1, ABCC3, ABCB8, ABCA2, ABCC1",1.44855000202712,0.723538195826756,TRUE +"H460","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.49963,-1.73,0.0217,16075,0.345,"LEF1, TCF7, SOS1, RARA, RUNX1, RAF1, STAT5A, PIM1, KRAS, PIK3CD, RPS6KB2, PIK3R3, AKT2, NRAS, RELA, BRAF, MAPK3, MAPK1, TCF7L1, SOS2, PPARD, STAT3, PIK3CA",1.66354026615147,0.462180904926726,FALSE +"H460","Input","KEGG_ADHERENS_JUNCTION",-0.51863,-1.79,0.0165,16075,0.512,"LEF1, PTPRF, TCF7, PTPRB, AFDN, CDH1, BAIAP2, RAC1, SORBS1, EP300, MAP3K7, RAC2, MAPK3, INSR, CTNND1, MAPK1, PTPN1, CDC42, NECTIN2, TCF7L1, CREBBP, NLK, SMAD3, WASF2, NECTIN3, TGFBR2, LMO7, CSNK2B, FYN, CSNK2A1",1.78251605578609,0.290730039024169,FALSE +"H460","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.24182,-0.841,0.691,16420,0.832,"MAPK10, PRKAB1, ACSL5, AKT2, RELA, ADIPOR2, NFKBIE, PPARA, CPT1B, MAPK8, STAT3, RXRB",0.160521952625802,0.0798766737092761,FALSE +"H460","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.31223,1.09,0.292,2951,0.433,"CPS1, GOT2, CAD, ADSL, ASS1, PPAT, GOT1",0.534617148551582,0.363512103646635,FALSE +"H460","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.3695,-1.32,0.132,11790,0.374,"FXYD2, SCNN1G, KCNJ1, ATP1B2, PIK3R2, HSD11B1, SCNN1B, PDPK1, PIK3CB, PRKCG, PIK3R1, ATP1A1, NR3C2, NEDD4L, SCNN1A, KRAS, PIK3CD, PIK3R3, MAPK3, INSR, MAPK1, PIK3CA",0.87942606879415,0.42712839779952,FALSE +"H460","Input","KEGG_ALLOGRAFT_REJECTION",0.34225,1.23,0.167,12576,0.33,"CD40, FAS, IL12A, CD86, CD80, PRF1, IFNG, CD40LG, IL2, CD28, GZMB, FASLG, IL5, IL4, IL10, IL12B, TNF",0.777283528852417,0.481486060122112,FALSE +"H460","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.24553,-0.847,0.672,18188,0.83,"PLA2G6, ACOX3",0.172630726946175,0.0809219076239261,FALSE +"H460","Input","KEGG_ALZHEIMERS_DISEASE",0.39065,1.38,0.114,3200,0.265,"CASP7, ATP5F1B, NDUFB10, SNCA, CASP9, NAE1, NDUFS2, ATP5MC1, HSD17B10, UQCRC2, ATP5MC3, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, NDUFB8, COX7C, CALM1, NDUFA5, NDUFA1, PLCB1, COX5A, COX7B, ITPR1, MAPT, IDE, GAPDH, NDUFB3, UQCRQ, NDUFB1, COX5B, CASP8, NDUFS6, SDHC, ATP5F1A, UQCRHL, SDHB, ATP5F1C, TNFRSF1A, NDUFS7, ATF6, NDUFV3, ATP5MC2, ATP5F1D, NDUFS4, NDUFA7, NDUFC1, COX6A1, COX6B1, UQCRH, PSEN2, CYCS, BACE2, SDHD, NDUFS5",0.943095148663527,0.576754126063192,FALSE +"H460","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.6345,2.33,0.00284,1069,0.0574,"IARS2, MARS2, FARSB, EARS2, DARS2, MTFMT, HARS2, LARS2, TARS2",2.54668165995296,1.24108810760203,TRUE +"H460","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.23375,0.849,0.634,4169,0.728,"UGDH, GPI, GALK2, PMM2, GNPDA1, GNPDA2, GNPNAT1, NANS, PGM2, HK1, HK2, NPL, NANP, GALE",0.197910742118267,0.137868620686963,FALSE +"H460","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.28873,-1.01,0.411,16132,0.62,"DERL1, CCS, PPP3CB, APAF1, MAPK13, CASP1, PPP3CA, RAC1, MAPK14, BCL2L1, RAB5A, CAT",0.386158178123931,0.207608310501746,FALSE +"H460","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.35367,1.26,0.174,1789,0.343,"HSP90AA1, CTSL, CANX, IFNA21, HSP90AB1, HSPA5, PSME3, HSPA1A, HSPA8, HSPA1B, TAP2, HSPA4",0.7594507517174,0.464705879957229,FALSE +"H460","Input","KEGG_APOPTOSIS",0.22691,0.806,0.705,1947,0.783,"CASP7, CASP9, AIFM1, NTRK1, IKBKG, ENDOG, TNFRSF10A, IRAK1, TRADD, BCL2, AKT1, PRKX, PRKAR1A, CHUK, CASP8",0.151810883008601,0.106238237942057,FALSE +"H460","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.46452,1.66,0.0483,656,0.173,"HPGDS, PLA2G4A, AKR1C3, GGT1, PTGES2, GPX3",1.31605286924849,0.761953896871205,TRUE +"H460","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.42754,1.53,0.0612,1837,0.201,"CPS1, GOT2, ALDH9A1, ODC1, ALDH18A1, CKB, SRM, LAP3, PYCR2, ALDH3A2, P4HA3, AGMAT, ALDH1B1, PYCR1",1.21324857785444,0.696803942579511,FALSE +"H460","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.26891,-0.941,0.5,11469,0.716,"SGCG, CACNG6, SGCA, CTNNA2, DAG1, SGCD, ITGB8, CACNG7, ITGA11, LAMA2, ITGA9, ACTN4, ITGB7, CACNA2D4, PKP2, CTNNB1, ITGA10, ITGA1, CACNA1D, CACNB4, ITGA4, ITGB1, CACNB3, LEF1, TCF7, ITGB6, ITGB3, ITGB4, ITGAV, ITGA7, ITGA2, CDH2, TCF7L1, DSP, ITGA3",0.301029995663981,0.145086977692144,FALSE +"H460","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.56121,1.97,0.0118,1779,0.102,"UGDH, ALDH9A1, ALDH3A2, ALDH1B1",1.92811799269387,0.991399828238082,TRUE +"H460","Input","KEGG_ASTHMA",-0.30735,-1.06,0.34,7286,0.627,"CD40LG, IL3, CCL11, IL5, IL4, IL10, PRG2, EPX, FCER1G, RNASE3, TNF, IL13",0.468521082957745,0.202732459169284,FALSE +"H460","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.33144,1.2,0.187,11222,0.328,"IFNA21, TPO, CD40, FAS, CD86, CD80, IFNA4, PRF1, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, IL2, CD28, GZMB, TSHR, FASLG, IL5, TSHB, IFNA13, IL4, CTLA4, IL10, CGA, IFNA8, IFNA1, IFNA5",0.728158393463501,0.484126156288321,FALSE +"H460","Input","KEGG_AXON_GUIDANCE",-0.37738,-1.33,0.119,15092,0.384,"PAK4, SEMA6A, SLIT3, SEMA4D, RASA1, EPHB6, PLXNB2, PLXNC1, PLXNA3, CXCR4, ITGB1, CDK5, PLXNA1, SRGAP1, NCK2, SEMA3F, PTK2, SLIT2, EFNB3, RND1, GNAI3, PPP3CB, GSK3B, SEMA4A, KRAS, SEMA3B, PAK6, ABLIM3, PAK2, CFL1, SEMA4B, PPP3CA, RAC1, NRAS, ROCK1, RAC2, EPHA1, MAPK3, SEMA4C, MAPK1, EFNB2, EPHB3, NRP1, CDC42, SRGAP3, SEMA7A, ARHGEF12, SEMA3C, NFAT5, PLXNB1, EPHB2, FYN",0.924453038607469,0.415668775632469,FALSE +"H460","Input","KEGG_BASAL_CELL_CARCINOMA",-0.33368,-1.16,0.235,12943,0.535,"WNT8B, WNT6, WNT16, PTCH1, PTCH2, HHIP, FZD1, WNT7A, WNT5B, CTNNB1, WNT4, AXIN2, APC2, STK36, WNT2B, WNT10A, LEF1, TCF7, FZD2, SUFU, APC, FZD6, GSK3B, WNT9A, BMP4, WNT7B, TCF7L1, DVL3",0.628932137728264,0.271646217978772,FALSE +"H460","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.21663,0.778,0.748,1987,0.82,"GTF2H2, GTF2E2, GTF2A2, TAF9, TAF9B, TAF5",0.126098402135539,0.0861861476162833,FALSE +"H460","Input","KEGG_BASE_EXCISION_REPAIR",0.56649,2.03,0.00612,2985,0.104,"NEIL3, APEX1, POLE3, PARP1, MPG, POLD2, NTHL1, POLE2, PARP2, LIG3, HMGB1, NEIL2, APEX2, LIG1, TDG, PCNA, SMUG1, UNG, POLE, POLD1",2.21324857785444,0.98296666070122,TRUE +"H460","Input","KEGG_BETA_ALANINE_METABOLISM",0.36169,1.32,0.118,1898,0.301,"ALDH9A1, SRM, ECHS1, ALDH3A2, AOC3, ALDH1B1, HADHA",0.928117992693875,0.521433504406157,FALSE +"H460","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29982,1.07,0.308,3570,0.449,"ELOVL6, HADHA, FADS1, ACOT2, SCD, HSD17B12, ACOT1, ACOT4, FADS2, HACD1",0.511449283499556,0.347753658996677,FALSE +"H460","Input","KEGG_BLADDER_CANCER",-0.42156,-1.47,0.0764,16325,0.439,"DAPK2, DAPK3, RAF1, KRAS, CDH1, MMP2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, DAPK1, VEGFA, VEGFB, THBS1",1.11690664142431,0.357535479757879,FALSE +"H460","Input","KEGG_BUTANOATE_METABOLISM",0.40645,1.44,0.106,2010,0.224,"AKR1B10, PDHA1, ALDH9A1, L2HGDH, HADH, ECHS1, ALDH3A2, ALDH1B1, HADHA, ACAT1",0.97469413473523,0.649751981665837,FALSE +"H460","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.4405,-1.53,0.0636,15329,0.396,"DAPP1, RASGRP3, SYK, CD22, SOS1, LILRB3, RAF1, PPP3CB, GSK3B, KRAS, PIK3CD, JUN, PIK3R3, PPP3CA, RAC1, AKT2, NRAS, RELA, CD72, NFKBIE, RAC2, MAPK3, IFITM1, MAPK1, SOS2, NFAT5, BCL10, PIK3CA",1.19654288435159,0.402304814074488,FALSE +"H460","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.20838,0.721,0.842,1786,0.893,"PDE1A, P2RX5, SLC25A6, VDAC1, SLC25A5, ADCY7, PHKA1, VDAC2, TBXA2R, PDE1C, NTSR1, CALM1, PTK2B, PLCB1, P2RX6, PPID, ITPR1, ADCY3, PRKX, PHKB, ATP2B1, BST1",0.0746879085003505,0.0491485411114536,FALSE +"H460","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.25388,0.936,0.495,3067,0.615,"CACNA2D3, UQCRC2, TPM3, COX7C, COX5A, COX7B, UQCRQ, COX5B, CACNB2, UQCRHL, ATP1B3, COX6A1, COX6B1, RYR2, UQCRH",0.305394801066431,0.211124884224583,FALSE +"H460","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.19249,0.697,0.871,734,0.921,"CD226, MPZ, NRCAM, CNTN1",0.0599818449923368,0.0357403698031511,FALSE +"H460","Input","KEGG_CELL_CYCLE",0.26094,0.952,0.448,3732,0.593,"YWHAE, GADD45G, ANAPC1, SMAD2, ANAPC5, MCM6, ANAPC7, E2F4, BUB3, CDC25A, SMC1A, YWHAG, PTTG1, PLK1, ORC1, CDC26, MCM7, CCNB1, MCM4, CCNH, BUB1, PKMYT1, SKP2, BUB1B, CUL1, ORC2, STAG2, CDK1, PCNA, SFN, ORC6, CDK7, E2F2, MYC, CDC45, CDC6, SMC3, ORC5, CDC25B, MAD2L1, CHEK2, CCND3, ESPL1, CDC23, ANAPC2, CCNA2, ORC4, CDC7, ANAPC11, CCNB2",0.348721986001856,0.226945306635737,FALSE +"H460","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.26526,-0.928,0.499,13226,0.733,"ADCY4, WASL, GNG3, VAV3, ROCK2, DOCK2, CXCL12, GRK4, PIK3CB, VAV1, XCL1, PRKCD, PRKCZ, NFKBIA, PIK3R1, CXCR6, ARRB1, GRK3, ADCY5, CCL26, JAK2, PXN, RASGRP2, CCL5, GNB1, GNG7, CX3CL1, CXCR4, CCL2, GNG2, GSK3A, SOS1, GNG4, SHC2, PTK2, TIAM1, RAF1, GNAI3, GNG5, GSK3B, CRKL, KRAS, PIK3CD, CCL28, PIK3R3, GRK5, RAC1, PRKACA, PREX1, AKT2, NRAS, RELA, BRAF, ROCK1, RAC2, MAPK3, MAPK1, CDC42, RAP1A, ADCY6, SOS2, BCAR1, TIAM2, STAT3, STAT2, PIK3CA, FOXO3",0.30189945437661,0.134896025358872,FALSE +"H460","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.50074,-1.74,0.0257,16534,0.396,"SHC2, RUNX1, RAF1, STAT5A, CRKL, KRAS, PIK3CD, PIK3R3, AKT2, NRAS, RELA, BRAF, MAPK3, CBLB, MAPK1, CDKN2A, SMAD3, CBL, MECOM, BCL2L1, GAB2, TGFBR2, SOS2, HDAC1, PIK3CA, CDKN1B",1.59006687666871,0.402304814074488,FALSE +"H460","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.55384,-1.91,0.0166,17307,0.404,"NR1D1, CSNK1E, ARNTL, PER3, CRY2",1.77989191195995,0.393618634889395,FALSE +"H460","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.64971,2.39,0,3190,0.0778,"FH, PDHA1, IDH3A, CS, SUCLG1, DLD, DLAT, MDH2, DLST, IDH1, IDH3B, IDH3G, ACLY, SDHC, SDHB, OGDH, ACO2, PDHB, SDHD",Inf,1.10902040301031,TRUE +"H460","Input","KEGG_COLORECTAL_CANCER",-0.40113,-1.38,0.105,16075,0.414,"LEF1, TCF7, MAPK10, APC, RAF1, GSK3B, KRAS, PIK3CD, JUN, PIK3R3, RAC1, AKT2, BRAF, RAC2, MAPK3, MAPK1, TCF7L1, SMAD3, MAPK8, TGFBR2, PIK3CA",0.978810700930062,0.382999658879101,FALSE +"H460","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.23859,-0.826,0.709,13582,0.842,"SERPINA5, VWF, C3, C3AR1, MASP2, C4BPB, F8, SERPINF2, C2, BDKRB1, C1R, CFI, SERPING1, SERPINE1, C4B, SERPINA1, F2R, BDKRB2, C4A, F3, C5, CFB, CD59",0.149353764816933,0.0746879085003505,FALSE +"H460","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.43015,1.54,0.0862,3562,0.201,"GOT2, AHCY, SRM, AHCYL2, MAT2A, LDHA, ENOPH1, LDHB, DNMT1, GOT1, MTAP, CTH, MTR, SMS, AHCYL1",1.06449273417529,0.696803942579511,FALSE +"H460","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.1737,0.6,0.977,1310,0.997,"TNFRSF8, IL18RAP, CXCL5, OSM, FLT4, IL18R1, CD70, CXCL1, IFNA21, EGF, CSF2RA, PF4V1, TNFSF9, IL22RA1, EDA2R, TNFRSF10A, CXCL8, IL6, CXCL2",0.0101054362812269,0.00130484168834428,FALSE +"H460","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.28,0.978,0.43,3016,0.562,"POLR3K, POLR3G, IFNA21, IKBKG, TREX1, IL6, POLR3B, CHUK, POLR3D, POLR3GL, POLR3A, TBK1, ADAR",0.366531544420413,0.250263684430939,FALSE +"H460","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.19571,-0.68,0.902,10525,0.979,"CACNB1, CACNG8, MYL3, CACNG1, ACTC1, CACNA2D2, ADCY2, TNNI3, IGF1, MYL2, SGCG, CACNG6, SGCA, DAG1, SGCD, ITGB8, CACNG7, ITGA11, TNF, LAMA2, ITGA9, ADCY4, ITGB7, CACNA2D4, ADCY5, TNNT2, ITGA10, ITGA1, TPM4, CACNA1D, CACNB4, ITGA4, ITGB1, CACNB3, TNNC1, ITGB6, ITGB3, ITGB4, ITGAV, ITGA7, PRKACA, ITGA2, TPM1, ITGA3, ADCY6",0.0447934624580583,0.00921730819686218,FALSE +"H460","Input","KEGG_DNA_REPLICATION",0.66538,2.34,0.0115,3867,0.077,"RNASEH1, POLE3, PRIM1, MCM6, RFC2, POLA1, POLD2, RFC5, RPA4, POLE2, SSBP1, MCM7, MCM4, LIG1, PCNA, DNA2, RFC3, RPA2, POLE, POLD1, FEN1, RNASEH2A, RPA1, MCM5",1.93930215964639,1.11350927482752,TRUE +"H460","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.44443,-1.54,0.0586,12777,0.449,"PIWIL2, NOTCH4, ETV7, ETS1, EGFR, SPIRE1, NOTCH2, SOS1, PIWIL4, KRAS, ETS2, MAPK3, MAPK1, SOS2, ETV6",1.23210238398191,0.347753658996677,FALSE +"H460","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.25493,0.902,0.5,2218,0.638,"ALDH3A1, GSTM1, GSTM3, GSTO2, MGST1, ALDH3B1, GSTM4, GSTO1, MGST2",0.301029995663981,0.195179321278838,FALSE +"H460","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.24597,0.903,0.546,2401,0.644,"UCK2, IMPDH1, CES2, HPRT1, IMPDH2, CES1, ITPA",0.262807357295263,0.191114132640188,FALSE +"H460","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.2311,0.831,0.616,255,0.754,"COL4A6, TNXB, LAMC3, LAMA1, SPP1, COL5A2",0.210419287835575,0.122628654130226,FALSE +"H460","Input","KEGG_ENDOCYTOSIS",-0.39122,-1.34,0.12,13552,0.383,"GRK4, MDM2, AP2A1, SMAP2, VPS37C, PLD2, KIT, IL2RG, PDGFRA, USP8, SH3GL3, CSF1R, EGFR, PRKCZ, ARRB1, GRK3, DNM3, ACAP1, STAM, SH3GL1, DNM1, STAM2, ARAP2, CHMP2A, EPN3, AGAP2, VPS36, CHMP3, CBLC, CXCR4, RAB11B, VTA1, CLTCL1, SH3GLB2, VPS4B, AP2A2, SMURF1, RAB11FIP1, RAB11FIP4, PIP5K1C, FGFR2, F2R, NEDD4L, SMAP1, ASAP1, PDCD6IP, RAB11A, DNM1L, ADRB2, PARD6A, AP2M1, CHMP5, TSG101, ARF6, GRK5, CBLB, CDC42, CHMP2B, ARFGAP3, ERBB3, ACAP2, PSD4, CBL, DAB2, PARD6B, CHMP4B, DNM2, ARAP1, ITCH, VPS37B, EHD2, TRAF6, RAB22A, ARFGAP2, RAB5A, PRKCI, SH3GLB1, SMURF2, VPS28, EPS15, RAB5B",0.920818753952375,0.416801226031377,FALSE +"H460","Input","KEGG_ENDOMETRIAL_CANCER",-0.44705,-1.56,0.05,14135,0.452,"EGFR, PIK3R1, CTNNB1, ERBB2, CCND1, AXIN2, APC2, LEF1, TCF7, SOS1, APC, RAF1, GSK3B, KRAS, PIK3CD, CDH1, PIK3R3, AKT2, NRAS, BRAF, MAPK3, MAPK1, TCF7L1, ILK, SOS2, PIK3CA, FOXO3",1.30102999566398,0.344861565188618,FALSE +"H460","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.26959,-0.92,0.513,13744,0.74,"PTPRZ1, IGSF5, EGFR, JAM2, NFKBIA, ATP6V1G2, ADAM10, CCL5, ATP6V1B2, MAPK11, F11R, PLCG1, MAPK10, ATP6V1A, HBEGF, MAPK13, ATP6V1E1, JUN, RAC1, ATP6V1C1, RELA, CDC42, MAPK14, MAPK8, ATP6V1H",0.289882634888184,0.130768280269024,FALSE +"H460","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.39252,-1.36,0.114,16073,0.395,"PLCG1, SOS1, MAPK10, NCK2, SHC2, PTK2, RAF1, BTC, STAT5A, GSK3B, CRKL, KRAS, PIK3CD, PAK6, HBEGF, PAK2, JUN, RPS6KB2, PIK3R3, AKT2, NRAS, BRAF, MAPK3, CBLB, MAPK1, ERBB3, TGFA, CBL, GAB1, MAPK8, SOS2, PIK3CA, CDKN1B",0.943095148663527,0.40340290437354,FALSE +"H460","Input","KEGG_ETHER_LIPID_METABOLISM",0.23702,0.862,0.587,1308,0.71,"PLA2G7, PLA2G4A, CHPT1",0.231361898752386,0.148741651280925,FALSE +"H460","Input","KEGG_FATTY_ACID_METABOLISM",0.30319,1.07,0.301,2664,0.449,"ALDH9A1, HADH, ECHS1, ALDH3A2, ACADSB, ALDH1B1, HADHA, ACAT1, ACAA2, ECI2, ACADS",0.521433504406157,0.347753658996677,FALSE +"H460","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.39513,-1.38,0.104,15701,0.414,"SYK, MAPK11, PLCG1, SOS1, MAPK10, PRKCE, RAF1, KRAS, PIK3CD, MAPK13, PIK3R3, RAC1, AKT2, NRAS, RAC2, MAPK3, MAPK1, MAPK14, PLA2G6, GAB2, MAPK8, SOS2, FYN, PIK3CA",0.98296666070122,0.382999658879101,FALSE +"H460","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.41854,-1.45,0.0894,13117,0.397,"LIMK2, PLA2G4F, WASL, AMPH, FCGR1A, VAV3, DOCK2, ARPC3, LAT, PIK3CB, VAV1, PLD2, SPHK1, PRKCD, PRKCG, PIK3R1, DNM3, SPHK2, DNM1, SYK, VASP, PLCG1, PLPP3, PIP5K1C, PRKCE, RAF1, ASAP1, DNM1L, CRKL, PIK3CD, CFL1, ARF6, RPS6KB2, PIK3R3, RAC1, AKT2, RAC2, MAPK3, MARCKSL1, MAPK1, CDC42, WASF2, PLA2G6, DNM2, GAB2, GSN, MARCKS, PIK3CA",1.04866248120408,0.401209493236885,FALSE +"H460","Input","KEGG_FOCAL_ADHESION",-0.30502,-1.06,0.349,13444,0.627,"VAV3, XIAP, ROCK2, THBS4, PGF, VWF, ACTN4, PIK3CB, VAV1, ITGB7, PDGFRA, PRKCG, COL5A1, LAMB3, THBS2, EGFR, PDGFA, PIK3R1, CTNNB1, ERBB2, CCND2, CCND1, ITGA10, ITGA1, PXN, LAMA3, MYLPF, CHAD, MYLK2, COL1A2, PAK4, PDGFC, ITGA4, RASGRF1, PPP1CA, PDGFD, ITGB1, VASP, COL11A2, SOS1, MYL9, ITGB6, ITGB3, LAMC2, PIP5K1C, MAPK10, COL6A2, SHC2, ITGB4, PTK2, FLNC, RAF1, ITGAV, ITGA7, LAMA4, MYL12A, GSK3B, CRKL, MYL12B, PIK3CD, BIRC3, PAK6, PARVA, PAK2, JUN, PIK3R3, RAC1, PPP1CB, ITGA2, AKT2, BRAF, ROCK1, RAC2, ARHGAP35, MAPK3, BIRC2, MAPK1, CDC42, VEGFA, TNC, PDGFB, ILK, ARHGAP5, MYLK, RAP1A, ITGA3, VEGFB, MAPK8, THBS1, TLN2, SOS2, BCAR1, FYN, PIK3CA",0.45717457304082,0.202732459169284,FALSE +"H460","Input","KEGG_FOLATE_BIOSYNTHESIS",0.39893,1.44,0.081,3512,0.224,"SPR, QDPR, PTS, DHFR",1.09151498112135,0.649751981665837,FALSE +"H460","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.40984,1.47,0.0667,4560,0.233,"AKR1B10, SORD, ALDOA, PFKM, PMM2, PFKP, PHPT1, KHK, AKR1B1, PFKL, ALDOC, HK1, HK2, MTMR2, TPI1, GMPPB, GMDS",1.17587416608345,0.632644078973981,FALSE +"H460","Input","KEGG_GALACTOSE_METABOLISM",0.3813,1.37,0.126,3880,0.267,"GLA, PFKM, GALK2, PFKP, G6PC2, AKR1B1, PFKL, PGM2, HK1, B4GALT2, HK2",0.899629454882437,0.573488738635425,FALSE +"H460","Input","KEGG_GAP_JUNCTION",0.18685,0.666,0.892,2889,0.952,"TUBB4A, EGF, ADCY7, SRC, TUBA1B, PLCB1, TUBB3, ITPR1, TUBA1A, ADCY3, PRKX, TUBA4A, CDK1, TUBAL3, GJA1, PRKCB, TUBB4B, TUBA1C",0.0496351456238769,0.0213630516155257,FALSE +"H460","Input","KEGG_GLIOMA",-0.33716,-1.16,0.228,13607,0.535,"MDM2, PIK3CB, E2F3, PDGFRA, PRKCG, EGFR, PDGFA, PIK3R1, CCND1, CALML6, PLCG1, SOS1, CALM3, SHC2, RAF1, KRAS, PIK3CD, PIK3R3, AKT2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, PDGFB, TGFA, SOS2, PIK3CA",0.642065152999546,0.271646217978772,FALSE +"H460","Input","KEGG_GLUTATHIONE_METABOLISM",0.53525,1.97,0.0151,2592,0.102,"G6PD, GSTM1, PGD, GSR, ODC1, GGT1, GPX3, GCLM, GCLC, GSTM3, GSTO2, RRM2, SRM, LAP3, IDH1, MGST1, GSTM4, GSTO1, MGST2, GGCT, GSTM2",1.82102305270683,0.991399828238082,TRUE +"H460","Input","KEGG_GLYCEROLIPID_METABOLISM",0.27647,0.991,0.401,1938,0.548,"GLA, DGKD, DGKG, ALDH9A1, GPAT3, ALDH3A2, ALDH1B1, AGK",0.396855627379818,0.261219441515631,FALSE +"H460","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.237,-0.828,0.693,17294,0.849,"DGKA, CDS1, ETNK1, LPCAT2, MBOAT2, CDS2, DGKH, PLA2G6, CHKA, ETNK2, CHKB",0.159266765388193,0.0710923097560473,FALSE +"H460","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.22591,-0.785,0.763,13271,0.868,"GCAT, MAOB, PIPOX, DMGDH, SRR, SARDH, GNMT, AMT, GATM, PSPH",0.11747546204512,0.0614802748235081,FALSE +"H460","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.44645,1.62,0.0562,3658,0.184,"ALDH3A1, PDHA1, ALDH9A1, ALDOA, PFKM, PGAM1, DLD, GPI, ENO1, DLAT, ALDH3A2, PGK1, GAPDH, ALDH3B1, ALDH1B1, LDHA, PFKP, G6PC2, PGAM4, LDHB, PDHB, PKM, PFKL, ALDOC, PGM2, HK1",1.25026368443094,0.735182176990464,FALSE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.34649,1.21,0.195,1325,0.334,"CHSY3, CSGALNACT1, XYLT1, CHST15",0.709965388637482,0.476253533188435,FALSE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.34926,1.21,0.209,1267,0.334,"GLCE, HS6ST2, XYLT1, HS3ST3B1, HS3ST3A1",0.679853713888946,0.476253533188435,FALSE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.40258,-1.4,0.0916,15626,0.417,"B3GNT7, CHST2, FUT8, ST3GAL3, B4GALT4, B3GNT2",1.03810452633215,0.379863945026242,FALSE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.26732,0.962,0.462,1267,0.583,"HYAL1, HS3ST3B1, HS3ST3A1",0.335358024443874,0.234331445240986,FALSE +"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.30879,1.12,0.253,965,0.404,"ST6GALNAC4, B4GALNT1, ST3GAL1",0.596879478824182,0.393618634889395,FALSE +"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.33252,1.2,0.196,965,0.328,"GLA, ST3GAL1",0.707743928643524,0.484126156288321,FALSE +"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.41974,-1.45,0.0711,10585,0.397,"FUT5, FUT9, B4GAT1, FUT6, B3GALT2, B4GALT1, FUT4, B3GALT1, B3GNT4, ABO, FUT2, B3GNT5, FUT3, B3GALT5, ST8SIA1, B3GNT3, FUT1, ST3GAL6, ST3GAL3, B4GALT4, B3GNT2",1.14813039927023,0.401209493236885,FALSE +"H460","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.13232,0.468,1,3367,0.999,"PIGF, PIGB, DPM2, PIGH, PIGO, PIGW",0,0.000434511774017692,FALSE +"H460","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.59993,2.17,0.0123,2690,0.0715,"MTHFD2L, CS, MTHFD1, PGP, MDH2, AFMID, MTHFD2, ACO2",1.9100948885606,1.14569395819892,TRUE +"H460","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.31803,-1.1,0.314,14994,0.619,"PLA2G12A, LHB, CACNA1D, GNRH1, MAP3K3, MAPK11, CALML6, GNRHR, SOS1, CALM3, MAPK10, RAF1, MAP3K4, KRAS, ITPR2, HBEGF, MAPK13, MMP2, JUN, PRKACA, MAP3K2, NRAS, MAPK3, MAPK1, CDC42, MAPK14, PLA2G6, MAPK8, ADCY6, SOS2, MAP3K1, MMP14",0.503070351926785,0.208309350979882,FALSE +"H460","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.34229,1.22,0.195,12576,0.335,"IL6, IL1A, FAS, CD86, CD80, PRF1, IFNG, KIR2DL1, KIR3DL2, IL2, CD28, KIR3DL1, KIR2DL3, GZMB, FASLG, KLRC1, KLRD1, IL1B, TNF",0.709965388637482,0.474955192963155,FALSE +"H460","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.30046,-1.04,0.349,12943,0.6,"WNT8B, WNT6, WNT16, PTCH1, PTCH2, HHIP, WNT7A, WNT5B, WNT4, BMP8A, CSNK1G2, FBXW11, STK36, WNT2B, WNT10A, BMP7, CSNK1G1, SUFU, CSNK1A1, GSK3B, RAB23, WNT9A, PRKACA, BMP4, CSNK1E, WNT7B",0.45717457304082,0.221848749616356,FALSE +"H460","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.26207,-0.911,0.564,11009,0.738,"CD19, GP5, CD3D, CD1D, CD33, CD38, CD7, IL11RA, CD36, CD44, THPO, CD34, IL1B, TNF, CD4, ITGAM, CD8A, IL1R2, GP1BA, FCGR1A, KIT, IL3RA, CSF1R, CSF2, ITGA1, ITGA4, CD9, ANPEP, CD22, IL7, IL7R, ITGB3, EPOR, IL11, MME, ITGA2, IL4R, CD59, FLT3LG, ITGA3",0.248720896016658,0.131943638176958,FALSE +"H460","Input","KEGG_HISTIDINE_METABOLISM",0.45304,1.6,0.0786,1779,0.179,"ALDH3A1, BUD23, ALDH9A1, AMDHD1, ALDH3A2, ALDH3B1, ALDH1B1",1.10457745396059,0.747146969020107,FALSE +"H460","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.4106,1.46,0.0941,3688,0.227,"XRCC3, RAD51D, POLD2, RAD51B, RPA4, SSBP1, XRCC2, RAD51C, RPA2, POLD1, EME1, SEM1, RPA1",1.02641037657274,0.643974142806877,FALSE +"H460","Input","KEGG_HUNTINGTONS_DISEASE",0.40269,1.46,0.0839,3200,0.227,"ATP5F1B, NDUFB10, SLC25A6, CASP9, NDUFS2, ATP5MC1, VDAC1, UQCRC2, SLC25A5, ATP5MC3, POLR2C, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, POLR2D, VDAC2, NDUFB8, COX7C, SOD1, NDUFA5, POLR2L, NDUFA1, PLCB1, COX5A, PPID, TFAM, COX7B, POLR2J3, ITPR1, NDUFB3, UQCRQ, POLR2I, NDUFB1, COX5B, CASP8, NDUFS6, BDNF, SDHC, ATP5F1A, CREB1, UQCRHL, AP2B1, SDHB, ATP5F1C, NDUFS7, POLR2A, DNAL1, NDUFV3, ATP5MC2, ATP5F1D, NDUFS4, VDAC3, NDUFA7, NDUFC1, POLR2E, COX6A1, COX6B1, UQCRH, CYCS, SDHD, NDUFS5",1.0762380391713,0.643974142806877,FALSE +"H460","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.20689,-0.709,0.875,10525,0.951,"CACNB1, CACNG8, MYL3, CACNG1, ACTC1, CACNA2D2, TNNI3, IGF1, MYL2, SGCG, CACNG6, SGCA, DAG1, SGCD, ITGB8, CACNG7, ITGA11, TNF, LAMA2, ITGA9, ITGB7, CACNA2D4, TNNT2, ITGA10, ITGA1, TPM4, CACNA1D, CACNB4, ITGA4, ACE, ITGB1, PRKAA1, CACNB3, TNNC1, ITGB6, ITGB3, ITGB4, PRKAB1, ITGAV, ITGA7, ITGA2, TPM1, ITGA3",0.0579919469776868,0.0218194830625861,FALSE +"H460","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.38151,-1.34,0.128,16073,0.383,"PLCG1, PIP5K1C, PIP4K2A, INPP1, PIK3CD, INPPL1, INPP4B, INPP5J, SYNJ2, SYNJ1, ALDH6A1, PIK3C2A, PLCD1, INPP5B, ISYNA1, PIK3CA",0.892790030352132,0.416801226031377,FALSE +"H460","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.28842,-1.02,0.413,15520,0.61,"PPP1CA, INPP5K, CBLC, CALML6, PRKAA1, PTPRF, SOS1, TSC1, CALM3, MAPK10, SHC2, PRKAB1, RAF1, GSK3B, CRKL, SOCS1, KRAS, PIK3CD, LIPE, RPS6KB2, PIK3R3, PPP1CB, PRKACA, SORBS1, AKT2, NRAS, BRAF, MAPK3, CBLB, INSR, MKNK1, MAPK1, PTPN1, CBL, MAPK8, SOS2, PRKCI, PHKG1, PIK3CA",0.384049948343599,0.214670164989233,FALSE +"H460","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.1641,-0.566,0.993,13425,1,"TNFSF13, CXCL12, ITGB7, MADCAM1, ITGA4, CXCR4, CCL28",0.00305075150461883,0,FALSE +"H460","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.30244,-1.04,0.371,13730,0.6,"PIK3CB, IL13, IL2RG, SPRED1, IL3RA, PIK3R1, CLCF1, CCND2, SPRED2, IL20RA, CSF2, CCND1, JAK2, IL20RB, STAM, CISH, STAM2, CBLC, IL23A, PIAS2, IFNAR2, TYK2, JAK1, IL7, IL7R, SPRY2, SOS1, IL10RB, EPOR, STAT5A, PIM1, SOCS5, IL11, SOCS1, PIK3CD, PIK3R3, IL6ST, AKT2, EP300, PIAS1, IFNGR2, CBLB, SPRY1, CREBBP, IFNGR1, IL4R, CBL, BCL2L1, SOS2, STAT3, IRF9, STAT2, PIK3CA",0.430626090384954,0.221848749616356,FALSE +"H460","Input","KEGG_LEISHMANIA_INFECTION",-0.4185,-1.45,0.0759,14672,0.397,"JAK2, NCF2, TLR2, TLR4, ITGA4, MAPK11, ITGB1, IRAK4, ITGB2, JAK1, MAPK13, JUN, RELA, MAP3K7, IFNGR2, MAPK3, MARCKSL1, MAPK1, IFNGR1, MAPK14, TRAF6, TAB2",1.11975822410452,0.401209493236885,FALSE +"H460","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.39162,-1.37,0.0968,12132,0.412,"NCF1, PIK3R2, CLDN14, VAV2, PECAM1, CDH5, CLDN7, VCAM1, CLDN23, CLDN10, CLDN3, ITGAM, MMP9, CYBB, VAV3, ROCK2, CXCL12, ACTN4, PIK3CB, VAV1, PRKCG, JAM2, PIK3R1, CTNNB1, NCF2, PXN, CLDN9, MYLPF, THY1, ITGA4, CXCR4, MAPK11, ITGB1, ITGB2, F11R, VASP, PLCG1, MYL9, ESAM, SIPA1, PTK2, GNAI3, MYL12A, AFDN, MYL12B, PIK3CD, MAPK13, MMP2, PIK3R3, RAC1, RASSF5, ROCK1, RAC2, ARHGAP35, CTNND1, CDC42, ICAM1, MAPK14, ARHGAP5, RAP1A, OCLN, BCAR1, PIK3CA",1.01412464269161,0.385102783966865,FALSE +"H460","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.70752,2.55,0,1898,0.0801,"ALDH9A1, ECHS1, ALDH3A2, ALDH1B1, HADHA",Inf,1.09636748391576,TRUE +"H460","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.31205,1.16,0.235,292,0.362,"AKR1B10, PLA2G4A",0.628932137728264,0.441291429466834,FALSE +"H460","Input","KEGG_LONG_TERM_DEPRESSION",-0.20412,-0.711,0.88,14374,0.96,"GNAO1, CACNA1A, GNAQ, GNA13, PLA2G12A, PPP2CB, RAF1, GNAI3, PPP2R1A, KRAS, ITPR2, NRAS, BRAF, MAPK3, MAPK1, PLA2G6",0.0555173278498314,0.0177287669604316,FALSE +"H460","Input","KEGG_LONG_TERM_POTENTIATION",-0.31608,-1.1,0.298,16365,0.619,"CALM3, RAF1, PPP3CB, KRAS, ITPR2, PPP3CA, PPP1CB, PRKACA, NRAS, BRAF, EP300, MAPK3, RPS6KA2, MAPK1, CREBBP, RAP1A",0.525783735923745,0.208309350979882,FALSE +"H460","Input","KEGG_LYSINE_DEGRADATION",0.34846,1.25,0.169,3207,0.335,"ALDH9A1, SUV39H1, SETD7, AADAT, DLST, HADH, ECHS1, ALDH3A2, ALDH1B1, HADHA, ACAT1, OGDH, PLOD3, KMT5A, ASH1L, TMLHE",0.772113295386326,0.474955192963155,FALSE +"H460","Input","KEGG_LYSOSOME",-0.30037,-1.04,0.354,13756,0.6,"AP1S2, PLA2G15, AP3D1, M6PR, LAMP1, DNASE2, CTSA, MCOLN1, CTSK, LAPTM4A, IDUA, NPC1, ACP5, AP3M2, LAPTM5, LAMP2, LAMP3, GNPTG, CLTCL1, CTSO, HEXA, SUMF1, SCARB2, FUCA1, SMPD1, GLB1, SLC17A5, AP1G1, PSAP, AP3S1, ARSA, ACP2, HGSNAT, ENTPD4, CTSB, CTSS, CTSV, MAN2B1, MANBA, MFSD8, NEU1, ATP6V1H, NPC2, CTSH, CD164, SORT1, TPP1",0.450996737974212,0.221848749616356,FALSE +"H460","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.29299,-1.02,0.392,15225,0.61,"MAP3K11, RASA1, CACNA1D, CACNB4, RASGRP3, RASGRF1, HSPB1, MAP3K3, STK3, MAPK8IP2, FGF1, MAPK11, CACNB3, TAOK1, RRAS, SOS1, DUSP16, FGFR2, MAPK10, GADD45A, NTF4, ATF2, FLNC, RAF1, PTPRR, PPP3CB, MAP3K4, CRKL, MAP3K6, KRAS, PAK2, MAPK13, DUSP8, JUN, PPP3CA, DDIT3, RAC1, PRKACA, FGF11, MAP3K2, AKT2, NRAS, RELA, BRAF, MAP3K7, RAC2, MAPK3, PPM1A, RPS6KA2, MKNK1, MAPK1, CDC42, STMN1, MRAS, MAPKAPK2, NLK, MAPK14, PDGFB, MAPK8IP1, SRF, PLA2G6, MECOM, RAP1A, RASA2, MAPK8, TGFBR2, DUSP10, TRAF6, LAMTOR3, SOS2, MAP4K3, RELB, MAP3K1, PPM1B, TAB2",0.406713932979543,0.214670164989233,FALSE +"H460","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.21355,-0.75,0.822,11298,0.92,"PDX1, HNF1A, HNF4A, MAFA, GCK, FOXA3, HNF1B, NR5A2, FOXA2, HES1",0.0851281824599496,0.0362121726544447,FALSE +"H460","Input","KEGG_MELANOGENESIS",-0.26768,-0.914,0.534,12802,0.742,"CAMK2A, CREB3L2, WNT8B, WNT6, WNT16, ADCY4, FZD1, WNT7A, WNT5B, KIT, PRKCG, CREB3L4, CTNNB1, ADCY5, WNT4, GNAO1, GNAQ, CREB3, WNT2B, WNT10A, CALML6, LEF1, TCF7, CALM3, FZD2, CREB3L1, RAF1, FZD6, GNAI3, GSK3B, KRAS, WNT9A, PRKACA, NRAS, EP300, MAPK3, WNT7B, MAPK1, TCF7L1, CREBBP, ADCY6, DVL3",0.272458742971444,0.129596094720973,FALSE +"H460","Input","KEGG_MELANOMA",-0.27922,-0.96,0.474,11042,0.685,"FGF7, PIK3CG, FGF8, HGF, IGF1, MET, FGF22, AKT3, FGF17, FGF21, MITF, PIK3R2, FGF9, RB1, FGF18, MDM2, PIK3CB, E2F3, PDGFRA, EGFR, PDGFA, PIK3R1, CCND1, FGF5, PDGFC, PDGFD, FGF1, RAF1, KRAS, PIK3CD, CDH1, PIK3R3, FGF11, AKT2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, PDGFB, PIK3CA",0.324221658325915,0.164309428507574,FALSE +"H460","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.43887,1.61,0.0408,2218,0.185,"ALDH3A1, GSTM1, AKR1C2, AKR1C1, EPHX1, AKR1C3, CYP1B1, GSTM3, GSTO2, MGST1, ALDH3B1, GSTM4, GSTO1, MGST2",1.38933983691012,0.732828271596986,TRUE +"H460","Input","KEGG_MISMATCH_REPAIR",0.64874,2.31,0.00573,2985,0.0539,"EXO1, RFC2, POLD2, RFC5, RPA4, SSBP1, LIG1, PCNA, RFC3, RPA2, POLD1",2.24184537803261,1.26841123481326,TRUE +"H460","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.38178,-1.32,0.125,15817,0.374,"PRKAA1, TSC1, HIF1A, CAB39L, PIK3CD, RPS6KB2, PIK3R3, AKT2, CAB39, BRAF, MAPK3, RPS6KA2, MAPK1, VEGFA, VEGFB, RICTOR, PIK3CA",0.903089986991944,0.42712839779952,FALSE +"H460","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.30396,-1.05,0.367,12133,0.636,"PIK3R2, PPP3R2, SH2D1B, VAV2, CHP1, TNF, ULBP2, TNFRSF10D, NFATC2, KLRC3, ULBP1, KLRK1, VAV3, LCK, LAT, PIK3CB, VAV1, KLRC2, PRKCG, PIK3R1, RAET1L, CSF2, ICAM2, HCST, SYK, ITGB2, IFNAR2, PLCG1, SOS1, SHC2, RAF1, PPP3CB, KRAS, PIK3CD, TNFSF10, PIK3R3, PPP3CA, RAC1, NRAS, BRAF, IFNGR2, RAC2, MAPK3, MAPK1, IFNGR1, ICAM1, SH3BP2, SOS2, NFAT5, FYN, PIK3CA",0.435333935747911,0.196542884351586,FALSE +"H460","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.13822,-0.478,0.998,8151,0.999,"NPY2R, GABRG1, TAAR1, GRM6, MC2R, FSHR, CYSLTR2, HTR1E, CRHR2, PRL, GPR83, P2RY10, P2RY4, HTR4, GABRB3, HCRTR1, APLNR, GRM1, P2RX3, TSHB, ADRA1A, HCRTR2, CCKAR, GABRA4, GLP1R, GPR50, CALCR, S1PR4, HTR2B, RXFP1, TRHR, HRH3, NR3C1, CHRNA4, MC5R, DRD5, CHRNB2, CCKBR, FPR2, HTR1F, AVPR1A, FPR3, GABRB2, GRM7, P2RX7, AVPR1B, TACR3, THRA, HTR2A, NPY5R, GRM5, NMUR2, F2, P2RY8, ADCYAP1R1, CGA, CHRNB4, PTGER2, CYSLTR1, GRIA1, GABRG3, UTS2R, NPFFR1, CHRM2, GRM3, GRIN2C, P2RX1, LPAR6, GHSR, GRIN2D, P2RY13, GABRA2, GHRHR, GABRR1, SSTR2, GABRD, F2RL3, CHRNA1, CHRM1, GABRB1, GRIK3, CRHR1, ADORA3, PTGER3, GABRA5, PRSS1, GRIA3, MCHR2, CHRNA9, CHRNA3, CALCRL, MCHR1, PTGER1, GRM2, GRM8, P2RX2, GRIA2, EDNRB, GRID2, DRD1, CTSG, GRM4, HRH2, GRIA4, PRSS2, PTGIR, KISS1R, PLG, LPAR4, AGTR1, OPRD1, GRIN2A, GABRP, GRIN2B, SSTR1, P2RY14, PTH2R, ADRA2B, LPAR3, NPY1R, CNR1, DRD2, NPFFR2, ADRA2A, GABRG2, NPBWR1, TRPV1, FPR1, GRIK5, GRID1, HTR2C, PTGER4, OXTR, GALR3, PRLR, NMBR, GRIK4, GRIN1, GABRQ, HRH1, P2RY6, PTGFR, EDNRA, NPY4R, GRPR, GRIN3B, C3AR1, GPR156, ADRA1B, CHRNA10, CHRNE, GPR35, TACR2, CHRM4, GABRR2, LHB, GRIK2, GIPR, PRSS3, PTAFR, BDKRB1, S1PR1, HTR7, CHRM3, OPRL1, DRD4, GABRA3, P2RY2, GNRHR, ADORA2B, F2R, BDKRB2, VIPR1, P2RX4, ADORA2A, ADRB2, ADORA1, THRB, LPAR1, CHRNB1, P2RY11, F2RL1, S1PR2, LPAR2",0.000869458712628891,0.000434511774017692,FALSE +"H460","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.40897,-1.4,0.0894,15435,0.417,"NGFR, MAP3K3, MAPK11, IRAK4, CALML6, PSEN1, PLCG1, SOS1, CALM3, MAPK10, FRS2, SHC2, NTF4, RAF1, GSK3B, CRKL, KRAS, PIK3CD, MAPK13, JUN, TP73, PIK3R3, RAC1, AKT2, NRAS, RELA, BRAF, NFKBIE, MAPK3, RPS6KA2, MAPK1, CDC42, MAPKAPK2, MAPK14, GAB1, ARHGDIB, RAP1A, MAPK8, TRAF6, YWHAZ, SOS2, MAP3K1, PIK3CA, SORT1, FOXO3",1.04866248120408,0.379863945026242,FALSE +"H460","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.35394,1.24,0.177,1786,0.332,"NAMPT, PNP, NT5M, NT5C, BST1",0.752026733638193,0.478861916295964,FALSE +"H460","Input","KEGG_NITROGEN_METABOLISM",0.29713,1.06,0.332,887,0.458,"CPS1, CA12",0.478861916295964,0.339134521996131,FALSE +"H460","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.30548,-1.08,0.328,16420,0.622,"MAPK10, TAB3, BIRC3, MAPK13, CASP1, RELA, MAP3K7, PYCARD, MAPK3, BIRC2, MAPK1, NLRP1, ERBIN, MAPK14, MAPK8, TRAF6, TAB2",0.484126156288321,0.206209615309181,FALSE +"H460","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.36945,-1.25,0.169,16071,0.424,"MRE11, LIG4, POLM, DCLRE1C",0.772113295386326,0.372634143407267,FALSE +"H460","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.4574,-1.58,0.0432,16073,0.462,"PLCG1, SOS1, FHIT, RAF1, KRAS, PIK3CD, PIK3R3, RASSF5, AKT2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, TGFA, SOS2, RXRB, PIK3CA, FOXO3",1.36451625318509,0.335358024443874,FALSE +"H460","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.4997,-1.72,0.0245,15409,0.311,"MAML2, NOTCH2, DLL1, RBPJ, MFNG, PSEN1, NUMB, KAT2B, DTX3L, DTX4, EP300, JAG1, MAML1, CREBBP, LFNG, RFNG, DVL3, HES1, CIR1, HDAC1, DTX2",1.61083391563547,0.507239610973163,FALSE +"H460","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.39236,1.44,0.0823,3841,0.224,"GTF2H2, POLE3, RFC2, CUL4A, POLD2, RFC5, RPA4, POLE2, CCNH, ERCC8, LIG1, PCNA, RFC3, CDK7, RPA2, POLE, POLD1, XPA, GTF2H3, ERCC3, RAD23B, RPA1, XPC",1.08460016478773,0.649751981665837,FALSE +"H460","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.23208,-0.806,0.746,15016,0.861,"MAN2A2, ALG2, ALG8, MAN1C1, MGAT3, ALG6, ALG11, FUT8, DDOST, MGAT5B, MGAT4A, MAN1A1, MAN1A2",0.127261172527331,0.0649968485463452,FALSE +"H460","Input","KEGG_OLFACTORY_TRANSDUCTION",0.2195,0.764,0.747,11747,0.836,"PDE1C, CALM1, ARRB2, ADCY3, PRKX, OR6A2, OR10AD1, OR10A2, GNAL, CAMK2D, OR1F1, CALM2, OR1L8, OR2AT4, PRKG2, OR2AG1, OR7C1, PRKACB, OR1Q1, OR6C6, OR52J3, OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR52D1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR13J1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, CLCA1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR2AE1, OR5AK2, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2H2, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, CNGA3, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR7D2, OR1B1, OR2L3, OR8D1, OR51E2, OR11H6, PDC, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5B21, OR5M11, OR13G1, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR51I1, OR5P3, OR52N2, OR8S1, OR9A2, OR51Q1, OR13D1, OR8D2, OR2T33, OR1J2, OR2S2, OR2A5, OR52H1, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, OR2T8, CALML3, OR4D1, OR2C1, OR8G1, CALML5, OR4F15, OR52B6, OR2A25, OR2D3, OR10H1, OR8A1, OR2B2, OR1K1, OR56B4, OR2J3, OR10A6, OR2A2, OR1J1, OR8G5, OR4F3, OR11H4, OR10A4, GUCY2D, OR51B4, OR13A1, OR6B2, OR2A12, OR2D2, OR10A3, OR2K2, PRKG1, CNGB1, OR13H1, OR2A14",0.126679398184601,0.0777937225609836,FALSE +"H460","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.50003,1.78,0.0442,3512,0.131,"MTHFD2L, MTFMT, ATIC, MTHFD1, SHMT2, SHMT1, MTHFD2, MTHFS, MTR, DHFR",1.35457773065091,0.882728704344236,TRUE +"H460","Input","KEGG_OOCYTE_MEIOSIS",0.22185,0.796,0.715,2884,0.794,"YWHAE, ADCY7, ANAPC1, ANAPC5, CALM1, AR, ANAPC7, MAPK12, SMC1A, ITPR1, YWHAG, PTTG1, AURKA, ADCY3, PLK1, PRKX, CDC26, CCNB1, BUB1, PKMYT1, CUL1, CDK1, PPP2R5C, PPP2R1B, PPP2CA, PPP1CC, CAMK2D, SLK, SMC3",0.145693958198919,0.100179497572904,FALSE +"H460","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.55136,-1.91,0.0147,15891,0.404,"HEXA, FUCA1, GLB1, MAN2B2, MAN2B1, MANBA, NEU1",1.83268266525182,0.393618634889395,FALSE +"H460","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.46153,1.7,0.0288,3200,0.157,"ATP5F1B, NDUFB10, NDUFS2, ATP5MC1, COX10, UQCRC2, ATP5MC3, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, COX15, ATP5ME, NDUFB8, COX7C, COX11, PPA1, NDUFA5, NDUFA1, COX5A, COX7B, NDUFB3, UQCRQ, NDUFB1, COX5B, NDUFS6, SDHC, ATP5F1A, UQCRHL, SDHB, ATP5F1C, NDUFS7, NDUFV3, ATP6V0D1, ATP5MC2, ATP5F1D, NDUFS4, ATP6V0E2, NDUFA7, NDUFC1, COX6A1, COX6B1, ATP6AP1, UQCRH, PPA2, SDHD, NDUFS5",1.54060751224077,0.804100347590766,TRUE +"H460","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.3466,1.23,0.209,1859,0.33,"GALNT16, GALNT13, GALNT14, ST3GAL1, C1GALT1C1, GALNT18, GALNT11",0.679853713888946,0.481486060122112,FALSE +"H460","Input","KEGG_P53_SIGNALING_PATHWAY",-0.25547,-0.88,0.604,13371,0.772,"ADGRB1, GADD45B, MDM2, CCNE2, DDB2, PMAIP1, CCND2, CCNE1, CCND1, SESN1, RRM2B, BBC3, SERPINE1, ATM, GADD45A, ZMAT3, APAF1, TP73, SESN2, CDKN2A, THBS1, SIAH1, CD82, CCNG2",0.218963061378868,0.112382699664264,FALSE +"H460","Input","KEGG_PANCREATIC_CANCER",-0.44057,-1.53,0.0687,16420,0.396,"MAPK10, RAF1, KRAS, PIK3CD, RALB, PIK3R3, RAC1, AKT2, RELA, BRAF, RAC2, MAPK3, MAPK1, CDKN2A, CDC42, VEGFA, SMAD3, TGFA, RALA, BCL2L1, VEGFB, MAPK8, TGFBR2, STAT3, PIK3CA",1.16304326294045,0.402304814074488,FALSE +"H460","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.38375,-1.34,0.123,10754,0.383,"DPYS, ENPP1, ENPP3, UPB1, VNN2, VNN1, PANK4, PANK3, PPCS, DPYD",0.910094888560602,0.416801226031377,FALSE +"H460","Input","KEGG_PARKINSONS_DISEASE",0.55018,1.96,0.0182,3200,0.0925,"PRKN, ATP5F1B, NDUFB10, SLC25A6, SNCA, CASP9, NDUFS2, ATP5MC1, VDAC1, UQCRC2, SLC25A5, ATP5MC3, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, UCHL1, VDAC2, NDUFB8, COX7C, NDUFA5, NDUFA1, COX5A, PPID, COX7B, NDUFB3, UQCRQ, NDUFB1, COX5B, HTRA2, NDUFS6, SDHC, ATP5F1A, UQCRHL, SDHB, ATP5F1C, NDUFS7, NDUFV3, UBB, ATP5MC2, ATP5F1D, NDUFS4, UBA1, VDAC3, NDUFA7, NDUFC1, COX6A1, COX6B1, PARK7, UQCRH, CYCS, SDHD, NDUFS5",1.73992861201493,1.03385826726097,TRUE +"H460","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.25758,0.934,0.469,4082,0.611,"NCL, ARHGEF2, TUBB4A, HCLS1, TUBA1B, CD14, TUBB3, TUBA1A, ARPC5L, TUBA4A, RHOA, TUBAL3, TUBB4B, TUBA1C, TUBB2B, EZR, TUBB2A, KRT18, ACTG1, ACTB, TUBA3D, TUBB6, ABL1",0.328827157284917,0.213958789757446,FALSE +"H460","Input","KEGG_PATHWAYS_IN_CANCER",-0.29691,-1.04,0.367,16043,0.6,"JAK1, FADD, PLCG1, LEF1, TCF7, SOS1, LAMC2, HIF1A, DAPK2, FGFR2, DAPK3, RARA, FZD2, MAPK10, NCOA4, PTK2, SUFU, RUNX1, ELOC, RBX1, APC, RAF1, ITGAV, FZD6, STAT5A, ARNT2, LAMA4, GSK3B, CRKL, KRAS, PIK3CD, BIRC3, CDH1, MMP2, WNT9A, CUL2, RALB, JUN, PIK3R3, CDKN2B, RAC1, RASSF5, FGF11, ITGA2, AKT2, NRAS, RELA, BRAF, BMP4, EP300, PIAS1, RAC2, MAPK3, BIRC2, CBLB, WNT7B, MAPK1, CDKN2A, CDC42, TCF7L1, CREBBP, DAPK1, VEGFA, EGLN2, SMAD3, PDGFB, TGFA, CBL, MECOM, RALA, FLT3LG, BCL2L1, ITGA3, VEGFB, MAPK8, TGFBR2, TRAF6, SOS2, DVL3, PPARD, HDAC1, STAT3, RXRB, PIK3CA, CDKN1B",0.435333935747911,0.221848749616356,FALSE +"H460","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.35682,1.28,0.138,1865,0.328,"UGDH, RPE, DCXR",0.860120913598763,0.484126156288321,FALSE +"H460","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.5638,2,0.0126,2290,0.108,"G6PD, PGD, TKT, PRPS1, TALDO1, ALDOA, PFKM, PRPS2, GPI, RPE, PFKP, RPIA",1.89962945488244,0.96657624451305,TRUE +"H460","Input","KEGG_PEROXISOME",-0.30624,-1.08,0.312,16111,0.622,"ACOX1, PEX7, XDH, PAOX, ACSL5, IDH2, PRDX5, PEX11G, PEX5, MLYCD, FAR2, ACOX3, ACOT8, PEX2, HMGCL, SCP2, CAT",0.505845405981557,0.206209615309181,FALSE +"H460","Input","KEGG_PHENYLALANINE_METABOLISM",0.56433,1.96,0.0211,1596,0.0925,"ALDH3A1, GOT2, HPD, PRDX6, AOC3, ALDH3B1",1.67571754470231,1.03385826726097,TRUE +"H460","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.31731,-1.09,0.322,15535,0.628,"INPP5K, CALML6, PLCG1, PIP5K1C, CALM3, PIP4K2A, INPP1, PIK3CD, ITPR2, PIK3R3, DGKA, INPPL1, INPP4B, INPP5J, CDS1, SYNJ2, SYNJ1, CDS2, DGKH, PIK3C2A, PLCD1, INPP5B, PIK3CA",0.492144128304169,0.202040356262804,FALSE +"H460","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.52074,1.82,0.0312,1873,0.119,"COX10, EARS2, HCCS, COX15, MMAB, BLVRB, FECH, BLVRA, UROD",1.50584540598156,0.924453038607469,TRUE +"H460","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.23813,-0.825,0.679,15730,0.833,"ACAA1, CYP27A1, ACOX1, ACSL5, SLC27A1, SORBS1, PPARA, CPT1B, ILK, ACOX3, SCP2, PPARD, RXRB",0.168130225719498,0.0793549985932124,FALSE +"H460","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.28596,1.02,0.391,1362,0.514,"SLC27A5, ACOX2, CYP39A1",0.407823242604133,0.289036881004724,FALSE +"H460","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.18797,-0.649,0.94,10646,0.977,"CD79A, ZAP70, CD19, CD3D, IGLL1, JAK3, CD4, CD8A, CIITA, LCK, RFXAP, BLNK, IL2RG, RAG1, IL7R, RFXANK, DCLRE1C",0.0268721464003014,0.0101054362812269,FALSE +"H460","Input","KEGG_PRION_DISEASES",0.30639,1.1,0.291,2117,0.425,"SOD1, HSPA5, IL6, LAMC1, NCAM2, HSPA1A, PRKX, STIP1",0.536107011014093,0.371611069949688,FALSE +"H460","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.27052,0.996,0.414,2295,0.548,"PDE3A, HSP90AA1, PDE3B, HSP90AB1, ADCY7, ANAPC1, ANAPC5, ANAPC7, CDC25A, MAPK12, ARAF, AKT1, ADCY3, PLK1, PRKX, CDC26, CCNB1, BUB1, PKMYT1, CDK1, MAPK9",0.382999658879101,0.261219441515631,FALSE +"H460","Input","KEGG_PROPANOATE_METABOLISM",0.45661,1.65,0.0447,2859,0.172,"ALDH9A1, ACSS3, SUCLG1, MCEE, ECHS1, ALDH3A2, ALDH1B1, HADHA, LDHA, ACAT1, ACACA, HIBCH, LDHB",1.34969247686806,0.764471553092451,TRUE +"H460","Input","KEGG_PROSTATE_CANCER",-0.33808,-1.16,0.258,13607,0.535,"MDM2, PIK3CB, E2F3, PDGFRA, CCNE2, CREB3L4, EGFR, NFKBIA, PDGFA, PIK3R1, CTNNB1, ERBB2, CCNE1, CCND1, CREB3, PDGFC, PDGFD, LEF1, TCF7, SOS1, FGFR2, CREB3L1, RAF1, GSK3B, KRAS, PIK3CD, PIK3R3, AKT2, NRAS, RELA, BRAF, EP300, MAPK3, MAPK1, TCF7L1, CREBBP, PDGFB, TGFA, SOS2, PIK3CA, CDKN1B",0.58838029403677,0.271646217978772,FALSE +"H460","Input","KEGG_PROTEASOME",0.66446,2.45,0.0069,3881,0.0822,"PSMB10, PSMB5, PSMA3, PSMD4, PSMD11, PSMC1, PSME3, PSMD14, PSMB6, PSMD1, PSMA6, PSMA4, PSMC5, PSMB4, POMP, PSMD7, PSMB7, PSMB3, PSMD12, PSMA7, PSMF1, PSMC6, PSMC2, PSMC4, PSMD3, PSMB8, SEM1, PSMB9, PSME2, PSMA1",2.16115090926274,1.08512818245995,TRUE +"H460","Input","KEGG_PROTEIN_EXPORT",0.21314,0.755,0.804,2667,0.842,"HSPA5, OXA1L, SRP68, SRP19, SPCS1, SEC11A",0.0947439512515487,0.0746879085003505,FALSE +"H460","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.23093,-0.801,0.726,8788,0.859,"ATP1A2, ATP1B4, ATP1A4, CA4, MDH1, PCK1, GLS, FXYD2, ATP1B2, SLC38A3, GLUD1, AQP1, GLS2, PCK2, ATP1A1, SLC4A4, GLUD2",0.139063379299906,0.0660068361687577,FALSE +"H460","Input","KEGG_PURINE_METABOLISM",0.50449,1.83,0.0282,3031,0.122,"PDE1A, PDE3A, GDA, PDE10A, PNPT1, PDE7B, PDE4D, POLR3K, NPR1, PFAS, POLR3G, PAPSS2, POLR2C, PDE3B, PRPS1, POLE3, NME1, ADCY7, IMPDH1, PNP, NT5M, POLR2D, ATIC, PRIM1, PDE4B, NT5C, PDE8B, PDE1C, PRPS2, NME2, POLA1, RRM2, POLR2L, NME4, HPRT1, AK2, POLD2, DGUOK, POLR2J3, POLE2, IMPDH2, ADCY3, POLR3B, NME3, GUK1, POLR2I, POLR1B, ADSL, POLR3D, NUDT9, ENTPD6, POLR1E, PAICS, POLR2A, POLR3GL, ITPA, POLR3A, NME5, PPAT, POLR2E, POLE, POLD1, POLR1A, PDE4A",1.54975089168064,0.913640169325252,TRUE +"H460","Input","KEGG_PYRIMIDINE_METABOLISM",0.49961,1.77,0.042,3137,0.129,"UCK2, PNPT1, POLR3K, POLR3G, POLR2C, TXNRD1, DHODH, POLE3, NME1, PNP, NT5M, POLR2D, PRIM1, NT5C, DTYMK, NME2, POLA1, RRM2, CAD, POLR2L, NME4, POLD2, CTPS1, POLR2J3, POLE2, POLR3B, NME3, POLR2I, POLR1B, POLR3D, ENTPD6, POLR1E, POLR2A, POLR3GL, ITPA, POLR3A, NME5, POLR2E, POLE, POLD1, POLR1A, TXNRD2, NT5C3A",1.3767507096021,0.889410289700751,TRUE +"H460","Input","KEGG_PYRUVATE_METABOLISM",0.53128,1.9,0.0132,3525,0.102,"PDHA1, ALDH9A1, ME1, HAGHL, DLD, ACYP1, DLAT, ME2, MDH2, ALDH3A2, ALDH1B1, LDHA, ACAT1, ACACA, LDHB, AKR1B1, PDHB, PKM, LDHD, GRHPR",1.87942606879415,0.991399828238082,TRUE +"H460","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.33182,-1.14,0.276,13444,0.562,"VAV3, ROCK2, ARPC3, IQGAP2, ACTN4, PIK3CB, VAV1, ITGB7, PDGFRA, ITGAX, EGFR, PDGFA, PIK3R1, MYH9, RRAS2, FGF5, CHRM4, ITGA10, ITGA1, PXN, APC2, GNA13, MYLPF, MYLK2, PAK4, PDGFC, BDKRB1, ITGA4, CHRM3, PPP1CA, PDGFD, FGF1, ITGB1, ITGB2, RRAS, SOS1, MYL9, ITGB6, ITGB3, PIP5K1C, FGFR2, PIP4K2A, F2R, BDKRB2, ITGB4, PTK2, TIAM1, APC, SSH2, RAF1, ITGAV, ITGA7, MYL12A, CRKL, MYL12B, KRAS, PIK3CD, PAK6, PAK2, CFL1, BAIAP2, PIK3R3, RAC1, PPP1CB, FGF11, ITGA2, NRAS, BRAF, ROCK1, RAC2, ARHGAP35, MAPK3, ARHGEF7, BRK1, MAPK1, CDC42, MRAS, WASF2, PDGFB, ARHGEF12, MYLK, PFN4, ITGA3, SOS2, BCAR1, GSN, TIAM2, PIK3CA",0.559090917934782,0.250263684430939,FALSE +"H460","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.18999,-0.655,0.93,15784,0.982,"ATG12, PRKAA1, ATG5, GABARAP, GABARAPL2",0.0315170514460649,0.00788851221305034,FALSE +"H460","Input","KEGG_RENAL_CELL_CARCINOMA",-0.5016,-1.75,0.0164,16164,0.473,"SOS1, FLCN, HIF1A, ELOC, RBX1, RAF1, ARNT2, CRKL, KRAS, PIK3CD, PAK6, PAK2, CUL2, JUN, PIK3R3, RAC1, AKT2, NRAS, BRAF, EP300, MAPK3, MAPK1, CDC42, CREBBP, VEGFA, EGLN2, PDGFB, TGFA, GAB1, RAP1A, VEGFB, SOS2, PIK3CA",1.7851561519523,0.325138859262188,FALSE +"H460","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.25803,0.926,0.494,1166,0.609,"NLN, THOP1",0.306273051076353,0.215382707367125,FALSE +"H460","Input","KEGG_RETINOL_METABOLISM",-0.17394,-0.607,0.978,8288,0.996,"ADH1B, RDH8, UGT2B4, ADH4, UGT2B17, CYP1A2, ADH1A, AWAT2, UGT2A3, CYP2C19, UGT2B15, CYP2A7, CYP2C9, CYP26C1, CYP26B1, CYP2B6, CYP2C18, CYP3A4, ADH1C, CYP4A22, CYP2A6, CYP2C8, LRAT, CYP26A1, ADH6, DHRS9, UGT2B7, RDH5, RDH16, BCO1, RETSAT, RDH12, CYP3A5, ALDH1A2, DGAT2, DHRS3, RDH10, CYP1A1, DGAT1",0.00966114521239857,0.00174066157630127,FALSE +"H460","Input","KEGG_RIBOFLAVIN_METABOLISM",0.40671,1.48,0.0846,2443,0.232,"RFK, FLAD1, ACP1, PHPT1",1.07262963696098,0.6345120151091,FALSE +"H460","Input","KEGG_RIBOSOME",0.60489,2.17,0.012,4206,0.0715,"RPS4Y1, RPS4X, RPL31, RPL22L1, RPL36AL, RPS23, RPS26, RPL38, RPL13, RPLP1, RPL23A, RPS2, RPL26L1, RPL3, RPL7A, RPL17, RPLP0, RPS29, RPL36A, RPS9, RPL35, RPS7, RPL27, RPS15A, RPL19, RPL26, RPL9, RPS15, RPS24, RPL14, RPL10, RPS27A, RPL23, RPL13A, RPL39, RPS21, RPS17, RPL4, RPL37A, RPS12, RPS10, RPL6, RPL29, RPL37, RPL36, RPL41, RPS27, RPL10A, RPS25, RPSA, RPL34, RPS27L, RPL12",1.92081875395238,1.14569395819892,TRUE +"H460","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.30382,-1.04,0.368,15508,0.6,"AZI2, MAPK11, ATG12, IFIH1, TKFC, FADD, MAPK10, ATG5, MAPK13, RELA, IRF7, MAP3K7, MAPK14, ISG15, RIPK1, MAPK8, TRAF6, CYLD, MAP3K1",0.434152181326482,0.221848749616356,FALSE +"H460","Input","KEGG_RNA_DEGRADATION",0.3458,1.25,0.162,1464,0.335,"HSPD1, PNPT1, HSPA9, EDC4, EXOSC2, MTREX, EXOSC8, ENO1, WDR61, EXOSC7, EXOSC1, CNOT1, EXOSC9",0.790484985457369,0.474955192963155,FALSE +"H460","Input","KEGG_RNA_POLYMERASE",0.6485,2.33,0.00943,3017,0.0574,"POLR3K, POLR3G, POLR2C, POLR2D, POLR2L, POLR2J3, POLR3B, POLR2I, POLR1B, POLR3D, POLR1E, POLR2A, POLR3GL, POLR3A, POLR2E, POLR1A",2.02548830726267,1.24108810760203,TRUE +"H460","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.55174,1.94,0.0155,1843,0.0941,"SCLY, BUD23, MARS2, PAPSS2, GGT1, AHCY, AHCYL2, MAT2A",1.80966830182971,1.02641037657274,TRUE +"H460","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.27722,-0.968,0.469,15761,0.69,"ITGB1, TRAF1, PIAS2, LAMC2, PTK2, FHIT, ITGAV, LAMA4, PIK3CD, BIRC3, APAF1, PIK3R3, CDKN2B, ITGA2, AKT2, RELA, PIAS1, BIRC2, BCL2L1, ITGA3, TRAF6, RXRB, PIK3CA, CDKN1B",0.328827157284917,0.161150909262745,FALSE +"H460","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.43415,-1.51,0.0556,17822,0.401,"SNAP29, SNAP23, VAMP5, STX7, VAMP3, TSNARE1, BET1, STX3, STX12, STX5",1.25492520841794,0.396855627379818,FALSE +"H460","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.2283,-0.799,0.744,12862,0.852,"DEGS2, ASAH1, SGPP2, GAL3ST1, SPHK1, ACER3, SPHK2, KDSR, SMPD3, CERK, PLPP3, SMPD1, GLB1, SGPL1, ARSA, SPTLC2, UGCG, NEU1",0.128427064454121,0.0695604052332999,FALSE +"H460","Input","KEGG_SPLICEOSOME",0.43261,1.6,0.0467,3540,0.179,"SNRPF, HNRNPU, HNRNPM, SNRPB, PQBP1, HNRNPA3, PRPF4, HNRNPC, SRSF7, USP39, PRPF8, SNRPE, RBM8A, HSPA1A, HSPA8, HSPA1B, SNRPD3, PCBP1, HNRNPA1, ALYREF, SNRNP200, EIF4A3, SNRPG, SNRPA, SRSF1, CCDC12, PPIH, SRSF2, SRSF3, EFTUD2, SF3B4, U2AF2, SNRNP70, DDX46, ZMAT2, PHF5A, SNRPA1, SNRPD1, CTNNBL1, DDX23, LSM8, LSM6, HSPA6, TXNL4A, TCERG1, NCBP1, RBMX, HNRNPK, THOC3, PRPF6, LSM4, LSM7, PRPF40A, SRSF9, SNRPB2",1.33068311943389,0.747146969020107,TRUE +"H460","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.21776,0.816,0.705,2120,0.774,"UGDH, PYGB, GPI, PYGL, GBE1",0.151810883008601,0.111259039317107,FALSE +"H460","Input","KEGG_STEROID_BIOSYNTHESIS",-0.27849,-0.974,0.458,13959,0.688,"SQLE, CEL, MSMO1, SC5D, DHCR24, TM7SF2",0.339134521996131,0.162411561764489,FALSE +"H460","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.2603,0.927,0.523,959,0.615,"AKR1C2, AKR1C1, AKR1C3, CYP1B1",0.281498311132726,0.211124884224583,FALSE +"H460","Input","KEGG_SULFUR_METABOLISM",0.36449,1.3,0.161,1528,0.314,"PAPSS2, SULT1A4, SULT1A1",0.79317412396815,0.503070351926785,FALSE +"H460","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.1358,0.476,1,1409,1,"SNRPB, SSB, SNRPD3",0,0,FALSE +"H460","Input","KEGG_TASTE_TRANSDUCTION",-0.20982,-0.735,0.845,13045,0.934,"TAS2R13, ADCY4, GNG3, TAS2R3, KCNB1, TAS2R20, CACNA1A, TAS2R10, GNB1, TAS2R4, TAS2R46, TAS2R31, SCNN1A, TAS2R14, TAS2R19, PRKACA, TAS2R5, ADCY6",0.0731432910503077,0.0296531237699066,FALSE +"H460","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.37443,-1.3,0.146,12475,0.379,"CDO1, GGT6, GGT5, ADO, CSAD, GGT7, GAD1",0.835647144215563,0.421360790031928,FALSE +"H460","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.33549,1.2,0.203,4809,0.328,"PMVK, PDSS1, ACAT1, FDPS, MVK, IDI1, ACAT2, GGPS1",0.692503962086787,0.484126156288321,FALSE +"H460","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.41502,-1.44,0.0756,15342,0.391,"BMP7, INHBE, INHBA, INHBB, PPP2CB, SMURF1, ID4, SP1, BMPR1B, ACVR1, RBX1, PPP2R1A, ACVR2B, RPS6KB2, CDKN2B, BMP4, EP300, ROCK1, RBL2, MAPK3, MAPK1, ACVR2A, CREBBP, SMAD3, LTBP1, THBS1, TGFBR2, ZFYVE9, SMAD7, BMPR2, SMURF2",1.12147820449879,0.407823242604133,FALSE +"H460","Input","KEGG_THYROID_CANCER",-0.46805,-1.61,0.0334,14209,0.452,"CTNNB1, CCND1, TFG, LEF1, TCF7, NCOA4, KRAS, CDH1, NRAS, BRAF, MAPK3, MAPK1, TCF7L1, RXRB",1.47625353318844,0.344861565188618,FALSE +"H460","Input","KEGG_TIGHT_JUNCTION",-0.29923,-1.03,0.371,13637,0.611,"MYH7B, ACTN4, MAGI3, EXOC4, IGSF5, PRKCD, PRKCG, YES1, PRKCZ, JAM2, PPP2R2A, CTNNB1, MYH9, MAGI2, PRKCQ, RRAS2, PPP2R2B, CLDN9, MYLPF, LLGL1, AMOTL1, TJP3, PPP2CB, EPB41L2, F11R, RRAS, MYL9, CTTN, MYH3, PRKCE, VAPA, GNAI3, MYL12A, PARD6A, AFDN, MYL12B, PPP2R1A, KRAS, CRB3, TJAP1, AKT2, NRAS, CGN, CDC42, MRAS, PARD6B, MAGI1, OCLN, PRKCI, CSNK2B, CSNK2A1",0.430626090384954,0.213958789757446,FALSE +"H460","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.27974,-0.966,0.45,15735,0.683,"MAPK11, IRAK4, TLR5, LY96, IFNAR2, FADD, MAPK10, TICAM2, PIK3CD, MAPK13, JUN, PIK3R3, RAC1, AKT2, RELA, IRF7, MAP3K7, MAPK3, MAPK1, MAPK14, TOLLIP, RIPK1, MAPK8, TRAF6, PIK3CA, TAB2",0.346787486224656,0.165579296318467,FALSE +"H460","Input","KEGG_TRYPTOPHAN_METABOLISM",0.35466,1.32,0.109,2420,0.301,"KYNU, ALDH9A1, TDO2, CYP1B1, AADAT, HADH, ECHS1, ALDH3A2, AFMID, ALDH1B1, HADHA, ACAT1, OGDH",0.962573502059376,0.521433504406157,FALSE +"H460","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.37996,-1.31,0.134,11667,0.376,"ABCC8, CACNA1B, HK3, MAFA, GCK, PIK3R2, CACNA1G, KCNJ11, TNF, SLC2A4, PIK3CB, PRKCD, PRKCZ, PIK3R1, CACNA1A, CACNA1D, MAPK10, PRKCE, SOCS1, PIK3CD, PIK3R3, MAPK3, INSR, MAPK1, MAPK8, PIK3CA",0.872895201635192,0.424812155072339,FALSE +"H460","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.31748,1.17,0.239,1387,0.356,"HSPD1, PTPRN",0.621602099051862,0.448550002027125,FALSE +"H460","Input","KEGG_TYROSINE_METABOLISM",0.34995,1.24,0.183,2003,0.332,"ALDH3A1, GOT2, BUD23, HPD, AOC3, ALDH3B1, FAH",0.737548910269571,0.478861916295964,FALSE +"H460","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.36309,-1.25,0.176,16073,0.424,"PLCG1, SOS1, NCK2, RAF1, PPP3CB, GSK3B, KRAS, PIK3CD, PAK6, PAK2, MAPK13, JUN, PIK3R3, PPP3CA, AKT2, NRAS, RELA, MAP3K7, NFKBIE, MAPK3, CBLB, MAPK1, CDC42, MAPK14, CBL, DLG1, SOS2, NFAT5, BCL10, FYN, PIK3CA",0.75448733218585,0.372634143407267,FALSE +"H460","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.39165,-1.36,0.111,15969,0.395,"PIAS2, SMURF1, FZR1, FBXW8, TRIM37, UBE3B, UBE2B, CDC16, UBE2H, UBE2E3, NEDD4L, ELOC, RBX1, CDC34, HUWE1, UBE2E1, SOCS1, FBXO2, BIRC3, CUL5, CUL2, UBE2J1, TRIM32, PIAS1, BIRC2, CBLB, UBR5, UBE2R2, HERC3, FBXW7, UBA7, CBL, SYVN1, UBOX5, ITCH, RNF7, TRAF6, SIAH1, UBE2Q2, CUL7, MAP3K1, SMURF2, UBE2W",0.954677021213343,0.40340290437354,FALSE +"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.73972,2.66,0,1031,0.0832,"IARS2, PDHA1, LARS2",Inf,1.07987667370928,TRUE +"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.33712,1.25,0.178,3266,0.335,"HSD17B10, ALDH9A1, DLD, MCEE, HADH, ECHS1, ALDH3A2, ACADSB, ALDH1B1, HADHA, ACAT1, ACAA2, MCCC2, ACADS, HIBCH, IVD, OXCT1",0.749579997691106,0.474955192963155,FALSE +"H460","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.26289,-0.903,0.555,13226,0.744,"ADCY4, PRKCH, PLA2G10, ROCK2, EDNRA, ACTG2, PRKCD, PRKCG, ADCY5, NPR2, PPP1R14A, PRKCQ, ADRA1B, GNAQ, GNA13, PLA2G12A, MYLK2, CACNA1D, PPP1CA, KCNMB4, CALML6, RAMP1, ADORA2B, MYL9, CALM3, KCNMA1, PRKCE, RAF1, ADORA2A, ITPR2, PPP1CB, KCNMB3, PRKACA, BRAF, ROCK1, MAPK3, MYL6B, MAPK1, ARHGEF12, PLA2G6, MYLK, ADCY6",0.255707016877324,0.128427064454121,FALSE +"H460","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.30143,-1.06,0.35,16619,0.627,"CREB3L1, RAB11A, PRKACA, DYNLL2, ARHGDIB, ADCY6, RAB5A, RAB5B",0.455931955649724,0.202732459169284,FALSE +"H460","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.34561,-1.19,0.212,16534,0.517,"SHC2, PTK2, RAF1, PPP3CB, KRAS, PIK3CD, MAPK13, PIK3R3, PPP3CA, RAC1, AKT2, NRAS, RAC2, MAPK3, MAPK1, CDC42, MAPKAPK2, VEGFA, MAPK14, PLA2G6, NFAT5, PIK3CA",0.673664139071249,0.286509456906058,FALSE +"H460","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.2502,-0.881,0.62,11911,0.78,"TJP2, ATP6V1G1, CFTR, ATP6V0D2, TJP1, ATP6V1D, ATP6V1C2, KDELR2, KCNQ1, PRKCG, SEC61A2, ATP6V1G2, ERO1A, SEC61A1, ATP6V1B2, KDELR3, KDELR1, PLCG1, ATP6V1A, ATP6V1E1, PRKACA, ATP6V1C1, ATP6V1H, SEC61G",0.207608310501746,0.10790539730952,FALSE +"H460","Input","KEGG_VIRAL_MYOCARDITIS",-0.19476,-0.665,0.917,11242,0.984,"ABL2, SGCG, SGCA, DAG1, SGCD, MYH11, MYH15, LAMA2, EIF4G2, MYH7B, MYH9, CCND1, ITGB2, MYH3, EIF4G3, RAC1, RAC2, ICAM1, FYN",0.0376306643299789,0.00700490156865849,FALSE +"H460","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.36756,-1.27,0.169,16027,0.414,"PSEN1, LEF1, TCF7, FZD2, MAPK10, RBX1, CSNK1A1, APC, FZD6, PPP3CB, GSK3B, PPP2R1A, PRICKLE2, PORCN, WNT9A, JUN, VANGL2, PPP3CA, RAC1, PRKACA, EP300, MAP3K7, LRP6, ROCK1, FRAT1, RAC2, CSNK1E, PPP2R5E, WNT7B, TCF7L1, CREBBP, NLK, SMAD3, CTNNBIP1, MAPK8, SIAH1, NFAT5, CSNK2B, SENP2, DVL3, PPARD, TBL1XR1, CSNK2A1, PPP2R5B, DAAM1",0.772113295386326,0.382999658879101,FALSE +"H1299","Input","KEGG_ABC_TRANSPORTERS",-0.27792,-1,0.436,13038,0.712,"ABCA9, ABCA10, ABCC8, ABCB11, ABCC9, ABCA8, ABCB4, ABCA6, ABCC2, ABCG1, ABCA13, ABCA4, ABCA12, ABCB10, ABCB6, ABCC6, ABCG2, ABCD3, ABCA2, ABCA5, ABCC3, ABCC1",0.360513510731414,0.147520006363144,FALSE +"H1299","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.29126,-1.08,0.322,17481,0.614,"PPARD, IKBKB, STAT3, MAPK3, STAT5A, RARA, JUP, STAT5B, ARAF",0.492144128304169,0.211831628858832,FALSE +"H1299","Input","KEGG_ADHERENS_JUNCTION",-0.36884,-1.33,0.15,15231,0.392,"BAIAP2, LMO7, CREBBP, ACP1, RAC1, TGFBR1, SRC, PTPRB, ERBB2, IGF1R, CTNNA1, NECTIN4, CDH1, NLK, FER, CTNND1, SORBS1, EP300, MAPK3, NECTIN1, PTPN6, SNAI2, RAC2, PTPRM",0.823908740944319,0.406713932979543,FALSE +"H1299","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.1888,-0.687,0.895,17457,0.949,"SLC2A1, ADIPOR1, CPT1C, IKBKB, ACSL5, PPARA, STAT3, RXRA, IRS2",0.048176964684088,0.0227337875727074,FALSE +"H1299","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.41181,-1.5,0.0798,14401,0.277,"GLS2, IL4I1, GLUD2, GLS, GFPT2, ACY3, GPT, DDO, GLUL, CPS1, ABAT, GFPT1, NIT2, ASS1",1.09799710864927,0.557520230935551,FALSE +"H1299","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.25321,0.853,0.641,2526,1,"PIK3CG, SCNN1G, SCNN1B, ATP1A3, PIK3CB, SGK1, PRKCG",0.193141970481183,0,FALSE +"H1299","Input","KEGG_ALLOGRAFT_REJECTION",0.22332,0.759,0.798,14847,1,"CD40, IL12A, IFNG, CD28, CD40LG, IL2, FASLG, IL12B, CD80, PRF1, FAS, IL4, IL10, CD86, GZMB, IL5, TNF",0.0979971086492706,0,FALSE +"H1299","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.42904,-1.57,0.0421,10518,0.298,"PLA2G12B, PLA2G4B, PLA2G5, PLA2G2C, PLA2G2F, PLA2G4E, PLA2G2A, PLA2G3, PLA2G6, PLA2G10, ACOX1, FADS2, PLA2G4A, PLA2G12A",1.37571790416433,0.525783735923745,FALSE +"H1299","Input","KEGG_ALZHEIMERS_DISEASE",-0.19494,-0.689,0.881,14669,0.965,"UQCRQ, NDUFA4, NDUFA4L2, ITPR3, TNF, CYCS, LPL, GRIN2C, CACNA1D, CAPN1, ADAM10, NDUFC2, BID, CDK5R1, NDUFV1, CACNA1C, NDUFB8, ITPR1, ATP2A3, COX6B2, BACE1, IL1B, GNAQ, NDUFS4, GSK3B, LRP1, NDUFB4, PSEN2, ATP5F1C, PLCB2, IDE, CASP8, NDUFA3, NDUFA1, UQCRC2, SNCA, BACE2, APH1A, MAPK3, ATF6, FADD, CASP7, EIF2AK3, PPP3CB",0.0550240915879521,0.0154726866562074,FALSE +"H1299","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.41419,1.44,0.0837,2864,0.572,"VARS2, DARS2, YARS2, RARS2, PSTK, FARSA, AARS2",1.07727454200674,0.242603971206976,FALSE +"H1299","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.37932,-1.4,0.0811,16173,0.34,"GFPT2, GMPPA, HEXA, RENBP, PGM1, GALE, NPL, NANP, HK1, MPI, GFPT1, NAGK, CYB5R1, PMM2",1.09097914578884,0.468521082957745,FALSE +"H1299","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.24191,-0.882,0.564,17291,0.761,"RAB5A, MAPK13, CCS, MAP2K6, CASP1, CAT, PPP3CB, GPX1",0.248720896016658,0.118615343229427,FALSE +"H1299","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.23634,0.798,0.728,1584,1,"HSP90AA1, IFNA13, HSP90AB1, HSPA1L, HSPA8, NFYC, HSPA1A, HSPA1B",0.137868620686963,0,FALSE +"H1299","Input","KEGG_APOPTOSIS",-0.20417,-0.734,0.824,14618,0.971,"EXOG, CASP6, IL1R1, TNF, BAX, CYCS, ENDOD1, IL3RA, CAPN1, BID, IKBKG, IL1A, IL1B, CHUK, PRKACB, NGF, TNFRSF10B, CASP8, IKBKB, TNFSF10, XIAP, FADD, CASP10, CASP7, PPP3CB, MYD88",0.0840727883028842,0.0127807700919951,FALSE +"H1299","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.46892,-1.69,0.0276,11297,0.282,"PLA2G5, CBR1, PLA2G2C, PLA2G2F, ALOX15B, CYP2C19, CYP2C9, CYP2E1, PLA2G4E, CYP2B6, PLA2G2A, CYP4A22, CYP4F2, PLA2G3, CYP2C18, PLA2G6, ALOX15, CYP2J2, GGT6, GGT5, PTGES, PTGIS, PLA2G10, TBXAS1, CYP4F3, ALOX5, GPX2, LTC4S, PTGS1, GPX7, PTGS2, GPX3, GGT1, PLA2G4A, AKR1C3, PLA2G12A, GPX1",1.55909091793478,0.549750891680639,FALSE +"H1299","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.23539,-0.858,0.612,14340,0.796,"AOC1, GLS2, CKMT2, SAT2, CKMT1B, GLUD2, MAOB, GLS, GLUL, AGMAT, PRODH, PYCR2, ALDH18A1, CPS1, P4HA2, ALDH2, P4HA1, ASS1",0.213248577854439,0.0990869322623309,FALSE +"H1299","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.28537,0.99,0.41,1220,1,"CACNG7, CACNB4, CACNG8, CACNG6, ITGA4, ITGA10, SLC8A1, ITGA6, CACNA2D1",0.387216143280265,0,FALSE +"H1299","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.43031,-1.52,0.0684,9337,0.302,"UGT2B10, UGT2B11, UGT2B17, ALDH1B1, UGT2B4, UGDH, ALDH9A1, UGT2A1, UGT2A3, UGT2B15, MIOX, UGT2B7, ALDH2",1.16494389827988,0.519993057042849,FALSE +"H1299","Input","KEGG_ASTHMA",0.2233,0.76,0.804,14847,1,"CD40, EPX, IL13, IL9, MS4A2, FCER1A, CD40LG, IL3, CCL11, IL4, IL10, PRG2, RNASE3, FCER1G, IL5, TNF",0.0947439512515487,0,FALSE +"H1299","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.22689,0.78,0.77,1138,1,"IFNA13, CD40",0.113509274827518,0,FALSE +"H1299","Input","KEGG_AXON_GUIDANCE",-0.40171,-1.48,0.0642,15000,0.281,"EFNB1, ABLIM2, PLXNC1, SRGAP3, CXCL12, UNC5A, SEMA4D, EPHB1, RAC1, FES, EPHA6, SLIT2, NTNG1, EPHB6, NTN4, CXCR4, GSK3B, EFNA5, NFATC2, SEMA3A, EFNA3, SEMA5A, EPHA1, EPHA4, EFNA1, PAK6, NRP1, EPHB2, EPHB3, SEMA7A, UNC5B, SEMA3F, ABLIM3, NCK2, PLXNB2, SEMA3B, L1CAM, LIMK2, MAPK3, RHOD, PLXNB1, RAC2, PLXNA2, PLXNB3, ABLIM1, PLXNA3, EFNA4, PPP3CB",1.19246497193115,0.55129368009492,FALSE +"H1299","Input","KEGG_BASAL_CELL_CARCINOMA",0.17837,0.606,0.974,4094,1,"WNT16, FZD9, APC2, WNT5B, DVL1, PTCH2, GLI1, SMO, WNT9A, STK36, FZD7, SHH, FZD1, DVL2",0.0114410431213845,0,FALSE +"H1299","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.34503,1.17,0.221,1899,0.91,"TBP, GTF2H4, TAF9, TAF9B, TAF6, TBPL1, TAF2, TAF5",0.655607726314889,0.0409586076789064,FALSE +"H1299","Input","KEGG_BASE_EXCISION_REPAIR",0.29973,1.02,0.375,2724,1,"XRCC1, POLE3, POLE2, NEIL2, UNG, POLD1, POLE",0.425968732272281,0,FALSE +"H1299","Input","KEGG_BETA_ALANINE_METABOLISM",0.18782,0.653,0.922,1279,1,"SMS, GAD1",0.0352690789463706,0,FALSE +"H1299","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29646,1.03,0.368,3901,1,"ELOVL2, ACOT7, ACOT2, ELOVL5, ACOX3, SCD",0.434152181326482,0,FALSE +"H1299","Input","KEGG_BLADDER_CANCER",-0.45861,-1.67,0.0495,16909,0.286,"ERBB2, DAPK2, FGFR3, EGF, CDH1, MMP2, CXCL8, MAPK3, VEGFA, VEGFB, DAPK1, ARAF",1.30539480106643,0.543633966870957,FALSE +"H1299","Input","KEGG_BUTANOATE_METABOLISM",-0.37555,-1.39,0.0922,15843,0.342,"HMGCL, OXCT1, HADH, AKR1B10, AACS, HMGCS1, ACSM3, ABAT, ALDH2, BDH1, BDH2",1.03526907894637,0.465973893943865,FALSE +"H1299","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.25418,-0.918,0.549,15494,0.744,"RASGRP3, IKBKG, VAV1, RAC1, BLNK, SOS2, CD81, PLCG2, CHUK, GSK3B, DAPP1, NFATC2, CARD11, SYK, IKBKB, VAV3, MAPK3, PTPN6, IFITM1, RAC2, PPP3CB",0.260427655549908,0.128427064454121,FALSE +"H1299","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.22894,0.792,0.73,2526,1,"PTGER1, NTSR1, CACNA1A, P2RX5, CACNA1B, GRIN2D, PLCD4, ADORA2A, ADRA1B, TBXA2R, SLC8A1, TRPC1, CALM1, MYLK2, PHKA1, F2R, PLCB4, SLC25A31, NOS3, PHKG2, ADORA2B, PRKCG",0.136677139879544,0,FALSE +"H1299","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.41512,1.45,0.0717,2224,0.606,"COX7B2, CACNG7, CACNB4, CACNG8, CACNG6, COX8C, SLC8A1, UQCRFS1, TPM2, CACNA2D1, CYC1, ATP1A3, UQCRB, COX6B1, COX4I1",1.1444808443322,0.217527375833714,FALSE +"H1299","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.2909,-1.05,0.362,13596,0.644,"CLDN14, CD22, ITGA9, ITGB7, CADM3, SELL, VCAM1, CDH5, CDH4, CLDN16, CLDN3, CD34, CLDN2, ITGB2, ESAM, ITGAV, NLGN4X, CD6, SDC3, CNTNAP2, NRXN2, CLDN9, CD8A, MPZ, CD276, F11R, NRXN3, CLDN11, VCAN, PDCD1LG2, SELPLG, NCAM1, MPZL1, CD58, NRCAM, CDH3, ICAM2, CLDN23, CLDN4, CD99, SDC2, CDH1, CLDN7, SDC1, CADM1, L1CAM, ITGB8, NECTIN1, ALCAM, PTPRM",0.441291429466834,0.191114132640188,FALSE +"H1299","Input","KEGG_CELL_CYCLE",0.47877,1.62,0.0444,4683,0.394,"CCNA1, E2F5, PRKDC, MCM7, BUB1, ANAPC4, DBF4, ESPL1, CDC20, CDKN2D, CCNB1, TTK, ANAPC13, MCM4, CDK7, PLK1, ORC3, RAD21, YWHAQ, MAD2L2, PTTG1, CCNB2, TGFB1, CDKN2A, CDC14A, E2F2, YWHAZ, MCM2, CDKN2B, E2F3, CDC25C, CDC25A, CDK6, ANAPC1, CCNA2, HDAC2, CHEK1, SMC1A, SMC1B, ATR, FZR1, MCM6, HDAC1, CDKN2C, ANAPC7, MCM5, ANAPC5, E2F4, GADD45B, CCNE2, TGFB3, ORC1, CCNH, CDC45, YWHAB, CUL1, E2F1, CDC7, PTTG2, CHEK2, MAD1L1, ZBTB17, ORC2",1.35261702988538,0.404503778174426,FALSE +"H1299","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.19879,-0.718,0.855,15596,0.989,"ADCY4, CXCL5, ADCY9, IKBKG, VAV1, RAC1, PRKCD, CXCL16, ADCY5, GRK7, CCL26, SHC3, CCL5, CXCR4, SOS2, CCL20, CHUK, GSK3B, PRKACB, ADCY6, CX3CL1, GRK2, CCL2, ADCY1, GNG2, ARRB1, PLCB2, STAT2, STAT1, IKBKB, VAV3, ADCY7, FOXO3, STAT3, RAP1A, CXCL8, MAPK3, RAC2, PTK2B, STAT5B",0.0680338852718274,0.0048037084028206,FALSE +"H1299","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.25172,0.874,0.607,3777,1,"PIK3CG, MECOM, TGFB1, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, HDAC2, CRK, CTBP1, PTPN11, CBL, AKT2, HDAC1, PIK3CD, NRAS, NFKB1, SHC1, RUNX1",0.216811308924742,0,FALSE +"H1299","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.37612,-1.35,0.113,16225,0.373,"CLOCK, BHLHE40, PER2, NR1D1, CRY2",0.94692155651658,0.428291168191312,FALSE +"H1299","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.38307,-1.4,0.0929,17118,0.34,"IDH3G, SUCLA2, FH, ACLY, MDH1, IDH1, PC, IDH2",1.03198428600636,0.468521082957745,FALSE +"H1299","Input","KEGG_COLORECTAL_CANCER",0.25852,0.879,0.601,5438,1,"PIK3CG, FOS, TGFB1, APC2, AKT1, APPL1, PIK3CB, AKT2, RAC3, PIK3CD, MSH3, BIRC5, MSH6, TGFB3, BAD, MLH1, RHOA, MSH2, MAPK9, PIK3R3, RAF1, MYC, JUN, MAPK10, SMAD4, CASP9",0.22112552799726,0,FALSE +"H1299","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.36445,-1.31,0.128,11642,0.4,"C5, F7, MASP1, FGA, F13A1, C6, PROS1, C4BPA, CR2, SERPIND1, FGG, FGB, F5, C5AR1, SERPING1, PLG, F8, A2M, C3AR1, VWF, SERPINA5, KLKB1, C4BPB, SERPINF2, TFPI, BDKRB1, PROC, CFI, PLAT, THBD, C2, BDKRB2, CD55, CFH, C3, C1S, CFB, F3, C1R, CD46",0.892790030352132,0.397940008672038,FALSE +"H1299","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.29925,1.03,0.388,5315,1,"CDO1, SMS, DNMT1, AHCY, CBS, LDHB, SRM, MTAP, ADI1, DNMT3A, APIP, TRDMT1, AMD1, AHCYL2",0.411168274405793,0,FALSE +"H1299","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.25288,-0.918,0.537,11532,0.744,"OSM, CX3CR1, IL10, IFNW1, CXCL9, CCL24, IL19, PF4, PDGFB, PPBP, IL12RB2, CCR9, IFNA21, CCL3L3, IL18RAP, IL1RAP, CCL25, TNFSF9, TNFSF4, IFNL2, LIF, IFNA8, IFNL3, IL10RB, CCL15, LIFR, IL2RA, CLCF1, IL23A, CCL3, TPO, IL2RB, LEPR, IL17B, IL13RA1, TNFRSF4, CCL22, EGFR, IFNA1, CCR3, IFNA5, CSF3, IFNL1, MET, KIT, IFNB1, CCR1, PRLR, KDR, EDAR, RELT, CXCL11, CCL17, TNFSF18, HGF, CXCL1, CCR7, CRLF2, FLT1, TNFSF14, CXCL3, CNTFR, IL20RA, IL12RB1, TSLP, IL5, TNFSF13B, IFNGR1, CXCL6, CXCL14, IL1R1, TNF, CXCL10, BMPR1A, IL21R, ACVRL1, IL3RA, IL2RG, IL24, IL17RB, IL7R, CXCL12, TNFSF15, PDGFRA, CD27, IL20RB, CXCL5, TNFRSF18, CSF2, CSF2RA, CSF1R, CXCL16, EDA2R, CCL26, IL1A, CCL5, IL1B, CXCR4, NGFR, IL22RA1, IL11, CCL20, TGFBR1, PDGFRB, IL1R2, TNFRSF11B, INHBE, TNFRSF10B, INHBB, CX3CL1, BMP2, IL15, CCL2, IFNLR1, IL6, EGF, INHBA, TNFRSF19, IL15RA, TNFSF10, TNFRSF21, TNFSF13, IL6R, CSF1, CXCL8, TNFSF12, IL18, VEGFA, TNFRSF14, KITLG, FLT3LG, VEGFB, PDGFA, LTBR",0.270025714300444,0.128427064454121,FALSE +"H1299","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.30995,-1.13,0.266,15724,0.578,"IKBKG, AIM2, POLR3B, CCL5, IL1B, CHUK, IL6, IKBKB, PYCARD, POLR1D, CASP1, MAVS, IKBKE, IL18, TREX1",0.575118363368933,0.238072161579471,FALSE +"H1299","Input","KEGG_DILATED_CARDIOMYOPATHY",0.25915,0.878,0.583,1574,1,"CACNG7, CACNB4, CACNG8, CACNG6, ITGA4, ITGA10, SLC8A1, TPM2, ITGA6, CACNA2D1, TGFB1",0.234331445240986,0,FALSE +"H1299","Input","KEGG_DNA_REPLICATION",0.59819,2.04,0.0112,3534,0.162,"MCM7, RFC1, MCM4, POLA1, PRIM1, RPA2, POLE3, POLE2, MCM2, POLD1, POLE, RFC2, RNASEH2A, RNASEH1, PRIM2, RPA1, MCM6, RFC5, MCM5",1.95078197732982,0.790484985457369,TRUE +"H1299","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.2771,-1,0.392,16413,0.712,"SOS2, FMN2, NOTCH1, ETV7, ETS2, MAPK3",0.406713932979543,0.147520006363144,FALSE +"H1299","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.41269,-1.53,0.056,9885,0.317,"UGT2B11, UGT2B17, GSTA3, CYP2A13, FMO2, UGT2B4, ADH7, ADH4, CYP1A2, FMO1, UGT2A1, UGT2A3, GSTM5, CYP2C19, UGT2B15, GSTP1, GSTA2, CYP2A7, GSTM3, FMO3, CYP2C9, CYP2E1, CYP2B6, CYP3A4, GSTA1, MAOA, ADH1C, GSTM4, CYP2C18, CYP2A6, GSTO1, CYP3A7, UGT2B7, GSTM1, MAOB, ALDH3B2, FMO5, MGST3, CYP3A5, MGST1, GSTZ1, ALDH1A3, CYP2D6, ALDH3A1, GSTO2, GSTT2, FMO4, MGST2",1.2518119729938,0.498940737782249,FALSE +"H1299","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.17863,-0.653,0.941,11225,0.96,"UGT2A1, CES5A, UPB1, UGT2A3, UGT2B15, CYP2A7, TYMP, DPYS, CYP3A4, CYP2A6, NAT2, TK2, CES1, CYP3A7, UPP1, UGT2B7, CES2, CYP3A5, CDA, NAT1",0.0264103765727431,0.0177287669604316,FALSE +"H1299","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.38238,-1.37,0.115,14594,0.357,"VTN, THBS2, ITGAV, VWF, CD36, COL5A3, SDC3, ITGA11, HSPG2, COL6A3, THBS1, ITGA1, COL1A2, COL3A1, COL4A4, CHAD, LAMA4, FN1, COL4A6, LAMA1, LAMC1, ITGB6, GP1BB, ITGB4, AGRN, TNC, COL5A2, SDC2, LAMB1, COL5A1, SV2A, LAMA3, SDC1, ITGB8, COL1A1, COL4A1, COL4A2",0.939302159646388,0.447331783887807,FALSE +"H1299","Input","KEGG_ENDOCYTOSIS",-0.22064,-0.805,0.744,15437,0.884,"VPS37C, PDGFRA, MDM2, ERBB3, AGAP2, PIP4K2B, PSD, CSF1R, NEDD4L, TFRC, RAB22A, GRK7, ARAP2, STAM, CXCR4, ARF6, SRC, EPS15, CHMP6, STAMBP, DNM1, GRK2, EPN3, CBLC, RAB5A, CHMP4B, IGF1R, LDLRAP1, ARRB1, ARFGAP2, FGFR3, CHMP2B, RAB11FIP1, ARAP1, EGF, RAB5B, FGFR2, RAB11FIP4, PARD6B, PARD6G, ACAP3, CBLB, TSG101, RAB5C, VPS25, PSD4, TRAF6",0.128427064454121,0.0535477349869269,FALSE +"H1299","Input","KEGG_ENDOMETRIAL_CANCER",-0.24859,-0.918,0.538,16413,0.744,"SOS2, GSK3B, ERBB2, PDPK1, CTNNA1, EGF, CDH1, FOXO3, MAPK3, ARAF",0.269217724333611,0.128427064454121,FALSE +"H1299","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.23971,-0.886,0.609,15427,0.77,"ADAM10, ATP6V0A1, IKBKG, ATP6V1E1, RAC1, ATP6V1A, ATP6V0A4, ATP6V1B2, CCL5, ATP6V1G2, F11R, PLCG2, CHUK, SRC, MAPK13, IKBKB, ATP6V1B1, ATP6AP1, ATP6V0E1, CXCL8",0.215382707367125,0.113509274827518,FALSE +"H1299","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.26719,-0.955,0.475,15648,0.719,"RPS6KB2, ERBB3, CAMK2B, SHC3, SOS2, NRG4, PLCG2, SRC, GSK3B, ERBB2, EREG, CBLC, BTC, PAK6, EGF, AREG, NCK2, GAB1, MAPK3, CBLB, STAT5A, STAT5B, ARAF",0.323306390375133,0.143271109617117,FALSE +"H1299","Input","KEGG_ETHER_LIPID_METABOLISM",-0.192,-0.693,0.903,16979,0.968,"LPCAT2, PLPP3, PLA2G4A, PLA2G12A",0.0443122496864942,0.0141246426916063,FALSE +"H1299","Input","KEGG_FATTY_ACID_METABOLISM",-0.21241,-0.775,0.775,13073,0.941,"ACSL6, CYP4A22, ADH1C, ACSL4, ECHS1, CPT2, CPT1B, EHHADH, ACSL1, ACOX1, ACAA1, HADHB, HADH, CPT1C, ACSL5, ALDH2",0.11069829749369,0.0264103765727431,FALSE +"H1299","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.18973,-0.688,0.936,13586,0.957,"PLA2G3, FCER1G, PLA2G6, GAB2, PRKCA, MAPK8, INPP5D, IL5, TNF, PLA2G10, CSF2, VAV1, RAC1, PRKCD, SOS2, PLCG2, PDPK1, SYK, MAPK13, VAV3, MAP2K6, PLA2G4A, MAPK3, RAC2, PLA2G12A",0.0287241512618947,0.0190880622231565,FALSE +"H1299","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.18159,0.618,0.972,4882,1,"PIK3CG, VASP, ARPC1A, DNM1L, PIKFYVE, ASAP1, AKT1, ARPC1B, PIK3CB, PLPP2, CRK, PRKCG, WASF1, AKT2, PLD2, MYO10, PIK3CD, CFL2, ASAP3, WASF2, PRKCE, ASAP2, GSN, ARPC5L, LIMK1, FCGR3A, WASF3, PIK3R3",0.0123337350737254,0,FALSE +"H1299","Input","KEGG_FOCAL_ADHESION",-0.20704,-0.759,0.803,15701,0.964,"COL6A3, VAV1, RAC1, THBS1, ITGA1, COL1A2, COL3A1, COL4A4, SHC3, SOS2, CHAD, SRC, GSK3B, PDGFRB, LAMA4, FN1, ERBB2, RASGRF1, COL4A6, LAMA1, LAMC1, PDPK1, ITGB6, ITGB4, IGF1R, PAK6, EGF, TNC, COL5A2, VAV3, LAMB1, COL5A1, LAMA3, XIAP, RAP1A, ITGB8, MAPK3, COL1A1, VEGFA, ARHGAP5, RAC2, VEGFB, COL4A1, COL4A2, PDGFA, PPP1CB",0.095284454721319,0.0159229660971692,FALSE +"H1299","Input","KEGG_FOLATE_BIOSYNTHESIS",0.24073,0.83,0.688,4660,1,"GGH, SPR, DHFR, PTS",0.162411561764489,0,FALSE +"H1299","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.55088,-1.96,0.0118,15333,0.279,"FPGT, ALDOA, FBP1, PFKFB3, GMPPA, AKR1B10, PFKFB4, PFKFB2, MTMR6, HK1, MPI, ALDOC, PMM2",1.92811799269387,0.554395796726402,FALSE +"H1299","Input","KEGG_GALACTOSE_METABOLISM",-0.3003,-1.07,0.355,16980,0.624,"PGM1, GALE, GLB1, HK1, B4GALT1",0.449771646944906,0.204815410317576,FALSE +"H1299","Input","KEGG_GAP_JUNCTION",-0.26765,-0.983,0.417,14284,0.718,"PRKCA, GUCY1A1, DRD2, TUBAL3, ITPR3, HTR2C, PDGFRA, ADCY4, ADCY9, TUBA8, ITPR1, ADCY5, LPAR1, TUBA3D, GNAQ, SOS2, SRC, PDGFRB, PRKACB, ADCY6, ADCY1, PLCB2, EGF, ADCY7, GJA1, MAPK3, PDGFA, TUBA4A",0.379863945026242,0.1438755557577,FALSE +"H1299","Input","KEGG_GLIOMA",0.22609,0.768,0.756,3610,1,"PIK3CG, CALM1, MTOR, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, PRKCG, AKT2, PIK3CD, NRAS, SHC1",0.121478204498793,0,FALSE +"H1299","Input","KEGG_GLUTATHIONE_METABOLISM",-0.41264,-1.5,0.0625,16112,0.277,"GGCT, GPX2, GSR, MGST3, MGST1, GSTZ1, GCLC, GPX7, GSTO2, GSTT2, GPX3, GGT1, IDH1, G6PD, IDH2, MGST2, GPX1",1.20411998265592,0.557520230935551,FALSE +"H1299","Input","KEGG_GLYCEROLIPID_METABOLISM",0.21209,0.722,0.849,2239,1,"GPAT2, AGPAT1, GPAT3, DGAT2, DGKE, PLPP2",0.0710923097560473,0,FALSE +"H1299","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.23145,0.782,0.768,2728,1,"GPAT2, PEMT, AGPAT1, LYPLA1, GPAT3, CHPT1, ACHE, DGKE, PLPP2, ETNK1, PTDSS1, LPCAT3",0.114638779968488,0,FALSE +"H1299","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.21311,0.738,0.834,804,1,"GLDC, ALAS1",0.0788339493622613,0,FALSE +"H1299","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.2349,-0.889,0.596,15309,0.791,"PCK2, ALDH3B2, ALDOA, FBP1, ALDH1A3, LDHA, PGM1, ALDH3A1, HK1, ALDH2, ACSS1, ALDOC, AKR1A1",0.224753740259764,0.101823516502323,FALSE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.18115,-0.674,0.94,14570,0.956,"B3GAT1, B3GAT3, CHPF, B4GALT7, XYLT1, CHST15",0.0268721464003014,0.0195421077238999,FALSE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.35545,-1.28,0.164,13971,0.393,"EXTL1, B3GAT1, B3GAT3, B4GALT7, EXT1, GLCE, XYLT1, HS6ST1, HS3ST1, HS6ST2, EXT2",0.785156151952302,0.405607449624573,FALSE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.57759,-2.15,0.00831,15489,0.439,"CHST1, CHST6, ST3GAL3, B3GNT7, B3GNT2, ST3GAL1, B4GALT4, B4GALT1",2.08039897621589,0.357535479757879,FALSE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.41674,-1.51,0.0638,16808,0.3,"HEXA, GLB1, IDUA, IDS, HGSNAT, NAGLU",1.19517932127884,0.522878745280338,FALSE +"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.33653,1.15,0.235,4284,0.842,"ST6GALNAC4, ST6GALNAC6, ST8SIA5, B4GALNT1, ST3GAL2, ST6GALNAC3, ST8SIA1",0.628932137728264,0.0746879085003505,FALSE +"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.52051,-1.91,0.0134,16808,0.235,"HEXA, GBGT1, FUT2, ST3GAL1, FUT1, B3GALNT1",1.87289520163519,0.628932137728264,TRUE +"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.40077,-1.5,0.0572,15219,0.277,"B3GALT5, ST3GAL4, ABO, ST3GAL3, FUT3, B3GNT3, B3GNT2, FUT2, B4GALT4, FUT1, B4GALT1",1.24260397120698,0.557520230935551,FALSE +"H1299","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.27392,-0.98,0.42,14781,0.714,"PIGY, PIGK, PIGM, PIGQ, PIGC, PIGB, PIGV, PIGS",0.3767507096021,0.146301788223826,FALSE +"H1299","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.4312,1.46,0.097,3418,0.649,"MDH2, MTHFD1L, MTHFD2L, MTHFD1, CS, GRHPR",1.01322826573376,0.187755303199631,FALSE +"H1299","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.24188,-0.888,0.586,14832,0.784,"ITPR3, PLA2G10, ATF4, CACNA1D, ADCY4, CACNA1C, ADCY9, ITPR1, PRKCD, CAMK2B, ADCY5, GNAQ, SOS2, SRC, PRKACB, ADCY6, ADCY1, MAPK13, PLCB2, MMP2, ADCY7, MAP2K6, PLA2G4A, MAPK3, PLA2G12A, MAP3K1, PTK2B",0.232102383981909,0.105683937315562,FALSE +"H1299","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.45297,-1.65,0.0582,8677,0.272,"IFNG, CD28, KIR2DL1, KIR3DL2, IL2, KIR3DL1, KIR2DL3, FASLG, CD80, PRF1, FAS, KLRC1, CD86, GZMB, TNF, IL1A, IL1B, IL6",1.23507701535011,0.565431095965801,FALSE +"H1299","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.20398,-0.75,0.821,16658,0.961,"GSK3B, PRKACB, WNT11, GAS1, BMP2, SUFU, GLI2, BMP4, WNT5A, BTRC, WNT7B",0.0856568428805592,0.0172766123314547,FALSE +"H1299","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.24664,-0.922,0.553,13245,0.764,"CD3D, THPO, CD7, CSF3, KIT, CD22, CD33, CD34, IL5, CD1D, IL1R1, TNF, IL3RA, CD36, IL7R, FCGR1A, CSF2, CD14, CSF2RA, CSF1R, TFRC, ITGA1, CD8A, IL1A, IL1B, IL11, IL1R2, GP1BB, IL6, CD55, IL6R, CSF1, KITLG, FLT3LG",0.257274868695302,0.11690664142431,FALSE +"H1299","Input","KEGG_HISTIDINE_METABOLISM",0.27812,0.949,0.491,397,1,"FTCD, BUD23",0.308918507877032,0,FALSE +"H1299","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.6082,2.07,0.00159,3832,0.209,"XRCC3, EME1, RAD54L, RAD51C, RAD54B, RAD52, RPA2, TOP3A, RAD51B, SEM1, POLD1, RAD51, RPA1, NBN, XRCC2",2.79860287567955,0.679853713888946,TRUE +"H1299","Input","KEGG_HUNTINGTONS_DISEASE",0.27481,0.932,0.505,3801,1,"COX7B2, DNAI1, TBP, POLR2D, COX8C, NDUFB9, UQCRFS1, IFT57, TBPL1, POLR2I, POLR2A, NDUFA9, CYC1, PLCB4, TGM2, SLC25A31, SDHB, DLG4, UQCRB, COX6B1, COX4I1, NDUFA7, ATP5MC1, HIP1, HDAC2, ATP5F1B, CLTA, RCOR1, TFAM, DNAL1, POLR2K, COX8A, NDUFS6, NDUFV2, SLC25A6, COX6C, HDAC1, HTT, POLR2J, TAF4B, NDUFB1, POLR2E, CLTC",0.296708621881339,0,FALSE +"H1299","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.30585,1.04,0.336,1574,1,"CACNG7, CACNB4, CACNG8, CACNG6, ITGA4, ITGA10, SLC8A1, TPM2, PRKAG2, ITGA6, CACNA2D1, TGFB1",0.473660722610156,0,FALSE +"H1299","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.26101,0.889,0.574,2189,1,"PIK3CG, ISYNA1, IMPA1, PLCD4, INPP5E, PIKFYVE, PLCB4, PIK3CB",0.241088107602027,0,FALSE +"H1299","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.1952,-0.714,0.877,16279,0.986,"SHC3, EIF4E2, PRKAB2, SOS2, GSK3B, PRKACB, PHKB, GYS1, MKNK1, PPP1R3B, PDPK1, PPP1R3D, CBLC, IKBKB, SOCS4, PHKG1, FLOT2, SORBS1, HK1, MAPK3, FOXO1, CBLB, PPP1CB, IRS2, ARAF",0.0570004066339595,0.0061230850587888,FALSE +"H1299","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.29015,0.985,0.447,1574,0.972,"MAP3K14, ITGA4, MADCAM1, CD40, TGFB1",0.349692476868064,0.0123337350737254,FALSE +"H1299","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.19629,-0.71,0.901,14369,0.982,"CNTFR, IL20RA, IL12RB1, TSLP, IL5, SPRY3, IFNGR1, IL21R, IL3RA, IL2RG, IL24, SOCS1, IL7R, PIAS1, IL20RB, CREBBP, CSF2, CSF2RA, STAT6, STAM, SOS2, IL22RA1, IL11, SOCS5, CISH, IL15, CBLC, STAT4, IFNLR1, IL6, STAT2, STAT1, IL15RA, SOCS4, STAT3, EP300, IL6R, PTPN6, IRF9, CBLB, STAT5A, STAT5B",0.045275209020937,0.00788851221305034,FALSE +"H1299","Input","KEGG_LEISHMANIA_INFECTION",-0.24432,-0.875,0.601,15945,0.767,"FCGR2A, IL1A, IL1B, TAB1, TLR2, TLR4, NCF2, PTGS2, MAPK13, STAT1, C3, MAPK3, PTPN6, TRAF6, MYD88",0.22112552799726,0.115204636051019,FALSE +"H1299","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.19773,0.673,0.903,4294,1,"PIK3CG, ITGAM, ITGA4, VASP, CLDN20, PXN, JAM3, BCAR1, MAPK11, MAPK12, PIK3CB, PTK2, CYBB, PRKCG, CLDN15, EZR, PTPN11, SIPA1, ICAM1, MYL9, PIK3CD, ACTG1, VCL, MYL12A, GNAI2, OCLN, MYL12B, MMP9, AFDN, CYBA",0.0443122496864942,0,FALSE +"H1299","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.47181,-1.71,0.0361,14291,0.336,"ECHS1, EHHADH, YOD1, ALDH2",1.44249279809434,0.473660722610156,FALSE +"H1299","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.49029,-1.76,0.0231,10518,0.396,"PLA2G12B, CYP1A2, PLA2G4B, PLA2G5, PLA2G2C, PLA2G2F, CYP2C19, CYP2C9, CYP2E1, PLA2G4E, CYP3A4, PLA2G2A, PLA2G3, CYP2C18, PLA2G6, ALOX15, CYP2J2, PLA2G10, CYP3A7, CYP3A5, AKR1B10, PLA2G4A, PLA2G12A",1.63638802010786,0.402304814074488,FALSE +"H1299","Input","KEGG_LONG_TERM_DEPRESSION",-0.17187,-0.621,0.97,11611,0.968,"PLA2G2F, GNA12, PPP2CB, GNAI3, PRKG2, GNA13, PRKCB, NOS1, PLA2G4E, GRID2, PLA2G2A, CRHR1, IGF1, PLA2G3, GRIA3, PLCB1, PLA2G6, PRKCA, GUCY1A1, PPP2R1A, ITPR3, PLA2G10, ITPR1, GNAO1, GNAQ, RYR1, IGF1R, PLCB2, PLA2G4A, MAPK3, PLA2G12A, ARAF",0.0132282657337552,0.0141246426916063,FALSE +"H1299","Input","KEGG_LONG_TERM_POTENTIATION",-0.29678,-1.08,0.297,14832,0.614,"ITPR3, ATF4, GRIN2C, CREBBP, CACNA1C, ITPR1, RPS6KA1, CAMK2B, GNAQ, PRKACB, ADCY1, PLCB2, EP300, RAP1A, MAPK3, RPS6KA2, PPP1CB, PPP3CB, ARAF",0.527243550682788,0.211831628858832,FALSE +"H1299","Input","KEGG_LYSINE_DEGRADATION",0.20615,0.702,0.863,3083,1,"EHMT2, NSD2, KMT5A, SETD1A, DLST, ACAT2, EHMT1, DOT1L",0.0639892042847904,0,FALSE +"H1299","Input","KEGG_LYSOSOME",-0.35284,-1.3,0.146,14720,0.393,"AP3S2, SLC11A2, NPC2, GNS, TPP1, PPT1, HYAL1, ATP6V0A1, GM2A, CD63, SMPD1, ATP6V0A4, GBA, GGA2, ACP5, GNPTAB, HEXA, CTSO, CTSH, ACP2, CTSB, ABCA2, GLB1, AGA, IDUA, CLN5, ARSA, ATP6AP1, FUCA1, GNPTG, SCARB2, LIPA, CTSS, LAMP1, IDS, CTSD, ASAH1, LAPTM4A, LAMP2, PSAP, HGSNAT, NAGLU, SUMF1",0.835647144215563,0.405607449624573,FALSE +"H1299","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.20847,0.715,0.87,3714,1,"CACNA1A, CACNG7, CACNB4, MAP3K14, CACNG8, CACNG6, CACNA1B, RELB, FLNC, NFKB2, NR4A1, DAXX, FOS, MEF2C, HSPA1L, HSPA8, FGF5, MAP3K12, CACNA2D1, SRF, STK4, MAP2K3, MAPK8IP2, FGF12, PAK2, HSPA1A, MECOM, TGFB1, MAP3K7, HSPA1B, MAPK11, RASGRP2, AKT1, MAP3K5, MAP2K2, DUSP1, MAPK12, FGF11, CRK, MAPKAPK3, PRKCG, TNFRSF1A, AKT2, RAC3, TRAF2, ECSIT, RRAS, HSPB1, JUND, MAPK7, MAP3K3, FGF1, PPP3R2, NRAS, NFKB1, MAP4K4, RPS6KA4, MAPK8IP1, ARRB2",0.0604807473813815,0,FALSE +"H1299","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.22963,0.784,0.75,208,1,"GCK",0.1249387366083,0,FALSE +"H1299","Input","KEGG_MELANOGENESIS",-0.22376,-0.821,0.722,15411,0.858,"WNT4, WNT7A, ADCY4, CREBBP, ADCY9, GNAO1, CAMK2B, ADCY5, DVL3, GNAQ, GSK3B, PRKACB, WNT11, ADCY6, ADCY1, PLCB2, CREB3L2, MITF, ADCY7, WNT5A, EP300, EDN1, MAPK3, WNT7B, KITLG",0.141462802430361,0.0665127121512946,FALSE +"H1299","Input","KEGG_MELANOMA",0.19777,0.669,0.918,3514,1,"PIK3CG, FGF5, FGF12, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, FGF11, AKT2, PIK3CD, FGF1, NRAS",0.0371573187987575,0,FALSE +"H1299","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.44672,-1.63,0.0492,11789,0.277,"AKR1C4, CYP2C19, UGT2B15, GSTP1, GSTA2, GSTM3, CYP2C9, CYP2E1, CYP1B1, CYP2B6, CYP2F1, CYP3A4, GSTA1, ADH1C, GSTM4, CYP2C18, GSTO1, AKR1C2, CYP3A7, UGT2B7, GSTM1, CYP1A1, ALDH3B2, MGST3, CYP3A5, MGST1, GSTZ1, ALDH1A3, ALDH3A1, AKR1C1, GSTO2, GSTT2, DHDH, EPHX1, CYP2S1, AKR1C3, MGST2",1.30803489723264,0.557520230935551,FALSE +"H1299","Input","KEGG_MISMATCH_REPAIR",0.51204,1.75,0.017,4775,0.462,"RFC1, RPA2, POLD1, RFC2, RPA1, RFC5, MSH3, MSH6, MLH1, POLD2, RFC4, MSH2",1.76955107862173,0.335358024443874,FALSE +"H1299","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.24636,-0.887,0.591,17065,0.777,"PDPK1, MLST8, HIF1A, MAPK3, VEGFA, DDIT4, VEGFB, RPS6KA2",0.228412519118745,0.109578981199086,FALSE +"H1299","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.17933,-0.653,0.945,14477,0.96,"KLRK1, SHC2, LCK, IFNGR1, ITGB2, TNF, KLRC2, RAET1G, BID, CSF2, VAV1, RAC1, SHC3, RAET1L, ULBP2, SOS2, SH3BP2, PLCG2, NFATC2, TNFRSF10B, ICAM2, SYK, VAV3, TNFSF10, MAPK3, PTPN6, RAC2, PTK2B, PPP3CB, ARAF",0.0245681914907371,0.0177287669604316,FALSE +"H1299","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.27024,0.925,0.522,949,1,"PTGER1, GABRA4, NTSR1, MC5R, S1PR1, NPFFR2, P2RX5, NMUR1, CHRNB1, GABRD, F2RL1, GRIN2D, ADORA2A, GABRB3, ADRA1B, TBXA2R, P2RY1, ADRA2C, MC1R",0.282329496997738,0,FALSE +"H1299","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.2068,0.714,0.861,3664,1,"PIK3CG, NFKBIB, CALM1, YWHAQ, ZNF274, SH2B3, IRAK2, MAPK11, AKT1, MAP3K5, MAP2K2, YWHAZ, PRDM4, MAPK12, NFKBIE, PSEN1, PIK3CB, CRK, RAPGEF1, PTPN11, AKT2, IRAK1, PIK3CD, TP73, MAPK7, MAP3K3, NRAS, NFKB1, SHC1, RPS6KA4",0.0649968485463452,0,FALSE +"H1299","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.48124,-1.72,0.0297,16535,0.404,"NT5C1B, NMNAT2, NAMPT, NT5C3A, NNMT, NMRK1, NADSYN1, QPRT, NUDT12, NNT",1.52724355068279,0.393618634889395,FALSE +"H1299","Input","KEGG_NITROGEN_METABOLISM",-0.44836,-1.65,0.0301,14401,0.272,"GLS2, HAL, GLUD2, CA14, GLS, CA8, CTH, GLUL, CA9, AMT, CPS1, CA12",1.52143350440616,0.565431095965801,FALSE +"H1299","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.27656,0.97,0.465,809,0.989,"HSP90AA1, CXCL2, CARD18, CARD8, NFKBIB, NLRP1, HSP90AB1, BIRC3",0.332547047110046,0.0048037084028206,FALSE +"H1299","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.2977,1.02,0.38,3035,1,"PRKDC, XRCC4, XRCC5",0.42021640338319,0,FALSE +"H1299","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.23522,0.814,0.714,3514,1,"PIK3CG, STK4, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, PRKCG, AKT2, PIK3CD, NRAS",0.146301788223826,0,FALSE +"H1299","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.26416,-0.969,0.401,16297,0.717,"CTBP2, DVL3, DTX1, MFNG, NOTCH1, MAML2, PSEN2, LFNG, DTX4, EP300, APH1A, CIR1, DTX3L",0.396855627379818,0.1444808443322,FALSE +"H1299","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.40729,1.38,0.11,3479,0.568,"ERCC1, RFC1, GTF2H4, CDK7, GTF2H5, RPA2, POLE3, ERCC3, POLE2, RAD23A, ERCC2, POLD1, POLE, RFC2, RPA1, RFC5",0.958607314841775,0.245651664288981,FALSE +"H1299","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.2575,-0.939,0.476,14460,0.736,"ST6GAL1, MGAT3, MOGS, MAN2A1, MGAT5, MGAT1, ALG9, ALG5, STT3A, ALG2, MGAT4A, MAN1C1, ALG11, MAN1A2, B4GALT1",0.322393047279507,0.133122185662501,FALSE +"H1299","Input","KEGG_OLFACTORY_TRANSDUCTION",0.20492,0.717,0.869,1072,1,"OR3A2, OR8G1, OR3A1, OR8D2, OR52H1, OR2J2, OR8G5, OR8A1, OR1F1, OR2W3, CALM1",0.0609802235513335,0,FALSE +"H1299","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.50595,1.74,0.0159,4076,0.386,"FTCD, MTHFD1L, TYMS, MTHFD2L, MTHFD1, GART, DHFR, ATIC",1.79860287567955,0.413412695328245,FALSE +"H1299","Input","KEGG_OOCYTE_MEIOSIS",0.33974,1.16,0.243,4362,0.894,"STAG3, FBXO43, BUB1, ANAPC4, ESPL1, CDC20, CCNB1, AURKA, CPEB1, ANAPC13, CALM1, PLK1, YWHAQ, MAD2L2, PTTG1, CCNB2, PPP2R5D, PPP2R5C, YWHAZ, MAPK12, CDC25C, ANAPC1, FBXO5, PPP1CC, SMC1A, SMC1B, SGO1, ITPR2, ANAPC7, PPP3R2, ANAPC5, CALM3, CCNE2, PRKX, PPP2R5E, YWHAB, CUL1, PTTG2",0.614393726401688,0.0486624812040823,FALSE +"H1299","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.46715,-1.69,0.0256,15905,0.282,"MAN2C1, GBA, HEXA, ENGASE, GLB1, AGA, FUCA1",1.59176003468815,0.549750891680639,FALSE +"H1299","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.22936,0.775,0.764,3724,1,"COX7B2, COX8C, NDUFB9, UQCRFS1, ATP5ME, ATP6V1C1, NDUFA9, CYC1, SDHB, UQCRB, COX6B1, COX4I1, NDUFA7, ATP5MC1, ATP6V1D, ATP5F1B, ATP6V0E2, NDUFA11, ATP6V1H, COX8A, NDUFS6, NDUFV2, COX6C, NDUFB1, COX10",0.11690664142431,0,FALSE +"H1299","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.4609,-1.71,0.038,15740,0.336,"ST6GALNAC1, GCNT4, GALNT6, GALNT9, GALNT2, GCNT3, GALNT5, GCNT1, GALNT1, ST3GAL1, GALNT7, GALNT3, GALNT12, B4GALT5",1.42021640338319,0.473660722610156,FALSE +"H1299","Input","KEGG_P53_SIGNALING_PATHWAY",-0.20368,-0.756,0.836,14685,0.959,"PTEN, SESN3, BAX, TSC2, CYCS, MDM2, BID, CCNE1, DDB2, THBS1, TNFRSF10B, SERPINB5, GADD45G, ZMAT3, CASP8, MDM4, SIAH1, CCNG2, SFN, IGFBP3, COP1",0.0777937225609836,0.0181813928293364,FALSE +"H1299","Input","KEGG_PANCREATIC_CANCER",-0.25745,-0.966,0.437,15724,0.713,"IKBKG, RAC1, ARHGEF6, TGFBR1, CHUK, ERBB2, EGF, STAT1, IKBKB, STAT3, MAPK3, VEGFA, RAC2, VEGFB, RALA, ARAF",0.359518563029578,0.146910470148134,FALSE +"H1299","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.41051,-1.48,0.0784,17871,0.281,"PANK2, PANK1, PPCS",1.10568393731556,0.55129368009492,FALSE +"H1299","Input","KEGG_PARKINSONS_DISEASE",0.29047,0.987,0.443,3628,0.996,"COX7B2, COX8C, LRRK2, NDUFB9, UQCRFS1, NDUFA9, CYC1, UCHL1, SLC25A31, SDHB, HTRA2, UQCRB, COX6B1, COX4I1, NDUFA7, ATP5MC1, ATP5F1B, UBE2G1, GPR37, COX8A, UBE2J2, NDUFS6, NDUFV2, SLC25A6, COX6C, PARK7, NDUFB1, UBB",0.35359627377693,0.00174066157630127,FALSE +"H1299","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.20995,0.718,0.848,4841,1,"ARPC1A, TUBB3, YWHAQ, NCL, YWHAZ, ARPC1B, TUBB6, EZR, TUBB4B, TUBA1C, ACTG1, TUBB, OCLN, TUBB4A, TUBA1A, TUBB2B, ARPC5L, ARHGEF2, RHOA, TUBA1B, TUBB2A",0.0716041477432862,0,FALSE +"H1299","Input","KEGG_PATHWAYS_IN_CANCER",-0.27059,-0.979,0.413,16579,0.706,"TGFBR1, PLCG2, CHUK, GSK3B, PDGFRB, LAMA4, BCR, FN1, WNT11, ERBB2, RASSF5, COL4A6, LAMA1, LAMC1, BMP2, PPARG, ELOB, CBLC, PTGS2, IGF1R, CUL2, CTNNA1, DAPK2, SUFU, SLC2A1, PPARD, FGFR3, IL6, FGF13, EGF, STAT1, CASP8, FH, IKBKB, CDH1, LAMB1, MITF, MMP2, FGFR2, HIF1A, GLI2, BMP4, ARNT2, WNT5A, LAMA3, STAT3, XIAP, RXRA, EP300, CXCL8, MAPK3, WNT7B, EGLN3, FADD, VEGFA, FOXO1, RAC2, CBLB, KITLG, TRAF4, FLT3LG, VEGFB, COL4A1, NCOA4, EPAS1, STAT5A, DAPK1, RARA, COL4A2, PDGFA, TRAF6, RALA, JUP, STAT5B, ARAF",0.384049948343599,0.151195298948196,FALSE +"H1299","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.32055,-1.15,0.231,9885,0.56,"UGT2B11, UGT2B17, UGT2B4, UGDH, AKR1B1, UGP2, UGT2A1, UGT2A3, UGT2B15, CRYL1, UGT2B7, DCXR, DHDH",0.636388020107856,0.2518119729938,FALSE +"H1299","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.32056,-1.15,0.242,16980,0.56,"PGM1, H6PD, RBKS, TKT, G6PD, TALDO1, ALDOC",0.616184634019569,0.2518119729938,FALSE +"H1299","Input","KEGG_PEROXISOME",-0.24,-0.883,0.572,14162,0.767,"PEX11B, SLC25A17, PXMP2, SLC27A2, EHHADH, ACSL1, PHYH, ACOX1, ACAA1, PEX11A, FAR1, PEX6, HMGCL, PIPOX, DDO, MVK, MPV17L, PRDX5, ABCD3, ACSL5, SCP2, IDH1, CAT, PEX12, NUDT12, DHRS4, IDH2",0.242603971206976,0.115204636051019,FALSE +"H1299","Input","KEGG_PHENYLALANINE_METABOLISM",-0.4242,-1.54,0.0493,11410,0.319,"TAT, AOC3, PAH, AOC2, DDC, MAOA, IL4I1, PRDX6, MAOB, ALDH3B2, ALDH1A3, ALDH3A1",1.30715308072277,0.496209316942819,FALSE +"H1299","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.1855,0.639,0.96,4331,1,"PIK3CG, IMPA1, PLCD4, INPP5E, CALM1, PIKFYVE, PLCB4, PIK3CB, DGKE, PRKCG, ITPR2, ITPKA, PIK3CD, DGKD, CALM3, INPP5K, SYNJ2, SYNJ1",0.0177287669604316,0,FALSE +"H1299","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.40441,-1.45,0.0595,14919,0.3,"BLVRA, UGT2B7, HMBS, EARS2, HMOX2, COX15, CP, MMAB, UROS, FTH1",1.22548303427145,0.522878745280338,FALSE +"H1299","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.2951,-1.09,0.308,14313,0.615,"CPT2, CPT1B, SLC27A2, EHHADH, FABP3, AQP7, ACSL1, NR1H3, ACOX1, ACAA1, LPL, CD36, PCK2, OLR1, UBC, PLIN1, PDPK1, PPARG, FADS2, CYP27A1, PPARD, CPT1C, FABP6, ACSL5, SCP2, ME1, PPARA, SORBS1, RXRA",0.511449283499556,0.211124884224583,FALSE +"H1299","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.27212,-0.987,0.437,13901,0.719,"CH25H, HSD17B4, CYP7B1, CYP27A1, HSD3B7, SCP2",0.359518563029578,0.143271109617117,FALSE +"H1299","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.16392,0.559,0.986,15984,1,"CD40, TAP2, CD19, UNG, TAP1, RFX5, RFXANK, TNFRSF13C, BTK, JAK3, ADA, ZAP70, RAG2, TNFRSF13B, CD40LG, CD8B, ICOS, CD3E, CD4, AICDA, AIRE, RFXAP, RAG1, DCLRE1C, PTPRC, CD3D, CD79A, CIITA, IGLL1, LCK, IL2RG, IL7R, IKBKG, BLNK, CD8A",0.0061230850587888,0,FALSE +"H1299","Input","KEGG_PRION_DISEASES",-0.31305,-1.15,0.248,16130,0.56,"IL1A, CCL5, IL1B, PRKACB, NOTCH1, NCAM1, LAMC1, IL6, MAPK3",0.605548319173784,0.2518119729938,FALSE +"H1299","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.3711,1.26,0.166,3712,0.694,"PIK3CG, HSP90AA1, CCNA1, BUB1, ANAPC4, CCNB1, CPEB1, HSP90AB1, ANAPC13, PLK1, MAD2L2, CCNB2, MAPK11, AKT1, MAPK12, PIK3CB, CDC25C, CDC25A, ANAPC1, CCNA2, PDE3B, AKT2, FZR1, PIK3CD, ANAPC7, ANAPC5, GNAI2",0.779891911959945,0.158640529545145,FALSE +"H1299","Input","KEGG_PROPANOATE_METABOLISM",-0.46552,-1.7,0.0254,14291,0.319,"ECHS1, EHHADH, ACACA, HIBCH, ACSS3, LDHA, SUCLA2, ABAT, ALDH6A1, ALDH2, PCCA, ACSS1, MCEE",1.59516628338006,0.496209316942819,FALSE +"H1299","Input","KEGG_PROSTATE_CANCER",-0.23597,-0.855,0.634,15482,0.793,"PDGFRA, MDM2, CCNE1, CREBBP, IKBKG, AR, SOS2, CHUK, GSK3B, PDGFRB, ERBB2, PDPK1, IGF1R, EGF, CREB3L2, IKBKB, FGFR2, EP300, MAPK3, FOXO1, PDGFA, ARAF",0.197910742118267,0.100726812682396,FALSE +"H1299","Input","KEGG_PROTEASOME",0.39336,1.34,0.136,2638,0.617,"PSMB1, PSMC4, PSMB7, PSMD8, PSMC1, PSMB6, PSMC5, PSMD7, PSMD4, PSMD14, PSMD1, SEM1",0.866461091629782,0.209714835966758,FALSE +"H1299","Input","KEGG_PROTEIN_EXPORT",-0.55924,-2.02,0.00529,15585,0.282,"SEC61B, SEC62, IMMP1L, SRP9, SRP54, SEC61G, OXA1L, SRP72, SPCS2",2.27654432796481,0.549750891680639,FALSE +"H1299","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.43501,-1.59,0.0545,13639,0.289,"ATP1B2, ATP1A2, FXYD2, GLS2, GLUD2, PCK2, AQP1, GLS, SLC38A3, ATP1A1, SLC4A4, MDH1",1.26360349772336,0.539102157243452,FALSE +"H1299","Input","KEGG_PURINE_METABOLISM",0.28487,0.995,0.424,3713,1,"AK5, POLR2D, NPR2, NME2, APRT, NT5E, AK4, POLR1E, POLA1, PRIM1, POLR3G, NME6, PFAS, PDE6D, PDE4A, PDE4C, POLR2I, POLR2A, POLE3, ENTPD5, AMPD2, POLE2, GMPS, NT5M, IMPDH2, NME1, POLR2K, POLD1, PDE3B, POLE, RRM2, PDE6B, RRM2B, GART, PRIM2, NUDT2, NME4, PNPT1, POLR2J, POLR2E",0.372634143407267,0,FALSE +"H1299","Input","KEGG_PYRIMIDINE_METABOLISM",0.37526,1.29,0.151,4271,0.659,"POLR2D, DHODH, NME2, DTYMK, NT5E, POLR1E, POLA1, PRIM1, POLR3G, TYMS, NME6, POLR2I, POLR2A, DUT, POLE3, ENTPD5, POLE2, CAD, NT5M, NME1, POLR2K, POLD1, POLE, UMPS, RRM2, RRM2B, PRIM2, NUDT2, NME4, PNPT1, POLR2J, POLR2E, TXNRD2, UCK2, POLR3H, POLR1C, CTPS1",0.821023052706831,0.18111458540599,FALSE +"H1299","Input","KEGG_PYRUVATE_METABOLISM",-0.27126,-1.01,0.378,17768,0.712,"HAGH, MDH1, ME1, PC, ALDH2, ACSS1",0.422508200162775,0.147520006363144,FALSE +"H1299","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.16551,0.572,0.992,4043,1,"PIK3CG, ITGAM, PAK4, ITGA4, ITGA10, PXN, PFN1, ARPC1A, FGF5, MYLK2, ITGA6, FGF12, PIKFYVE, PAK2, F2R, BCAR1, APC2, MAP2K2, ARPC1B, PIK3CB, PTK2, TIAM1, FGF11, CRK, EZR, PPP1CC, WASF1, RAC3, RRAS, PPP1R12A, MYH10, MYL9, PIK3CD, FGF1, NRAS, ACTG1, VCL, MYL12A, CFL2, FGD1, FGFR1, ITGA2, MYL12B, WASF2",0.00348832784582135,0,FALSE +"H1299","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.26931,0.924,0.532,4083,1,"IFNA13, PIK3R4, ATG7, ATG12, GABARAPL2, ATG5, ATG4B, ULK3",0.274088367704952,0,FALSE +"H1299","Input","KEGG_RENAL_CELL_CARCINOMA",-0.31509,-1.14,0.252,17178,0.569,"ELOB, CUL2, SLC2A1, PAK6, FH, HIF1A, ARNT2, EP300, RAP1A, GAB1, MAPK3, EGLN3, VEGFA, VEGFB, EPAS1, ARAF",0.598599459218456,0.244887733604929,FALSE +"H1299","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.31974,1.08,0.33,4412,1,"THOP1, MME, ANPEP, ENPEP, NLN",0.481486060122112,0,FALSE +"H1299","Input","KEGG_RETINOL_METABOLISM",-0.28171,-1.01,0.427,11816,0.712,"CYP2C19, UGT2B15, CYP2A7, CYP2C9, RPE65, CYP26C1, CYP2B6, CYP26A1, CYP3A4, CYP4A22, ADH1C, CYP2C18, DHRS3, CYP2A6, PNPLA4, CYP3A7, UGT2B7, CYP1A1, DHRS9, BCO1, RETSAT, RDH12, RDH16, CYP3A5, ALDH1A1, CYP26B1, DHRS4, DHRS4L2",0.369572124974976,0.147520006363144,FALSE +"H1299","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.51304,-1.91,0.0148,13276,0.235,"ENPP3, ACP4, MTMR7, FLAD1, ACP1, ACP5, ACP2, ACP6, MTMR6",1.82973828460504,0.628932137728264,TRUE +"H1299","Input","KEGG_RIBOSOME",0.33746,1.15,0.262,5670,0.842,"RPS20, RPL7, RPL13, RPS12, RPS16, RPL26L1, RPL8, RPL35A, RPL30, RPS4X, RPS10, RPSA, RPS19, RPS28, RPL18A, RPS15, UBA52, RPL9, RPL22, RPL29, RPL17, RPL11, MRPL13, RPL35, RPL14, RPS26, RPL41, RPL6, RPL31, RPL5, RPS21, RPS6, RPL3, RPS23, RPS7, RPLP0, RPS27A, RPL4, RPL38, RPL32, RPL37A, RPS9, RPL34, RPL26, RPS25",0.581698708680255,0.0746879085003505,FALSE +"H1299","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.2561,-0.954,0.461,16349,0.711,"DDX3Y, CYLD, OTUD5, CHUK, MAPK13, CASP8, IKBKB, MAVS, CXCL8, IKBKE, FADD, DHX58, CASP10, MAP3K1, TRAF6",0.336299074610352,0.148130399270234,FALSE +"H1299","Input","KEGG_RNA_DEGRADATION",0.38539,1.33,0.136,5451,0.602,"HSPD1, PAPOLA, SKIV2L, LSM7, EDC4, LSM2, DCP2, EXOSC10, EXOSC3, EXOSC5, EXOSC2, ENO1, CNOT9, CNOT7, PNPT1, EXOSC4, HSPA9, LSM3, CNOT3, LSM6, MTREX, ZCCHC7, MPHOSPH6, DCP1B, LSM4, LSM1, EXOSC7, EXOSC6",0.866461091629782,0.220403508742175,FALSE +"H1299","Input","KEGG_RNA_POLYMERASE",0.40475,1.39,0.106,4238,0.588,"POLR2D, POLR1E, POLR3G, POLR2I, POLR2A, POLR2K, POLR2J, POLR2E, POLR3H, POLR1C",0.97469413473523,0.230622673923862,FALSE +"H1299","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.31319,-1.11,0.264,14276,0.596,"GGT6, GGT5, MAT1A, HEMK1, CTH, LCMT1, GGT1, LCMT2, AHCYL1",0.578396073130169,0.224753740259764,FALSE +"H1299","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.21331,0.732,0.848,3546,1,"PIK3CG, LAMC3, TRAF3, BIRC3, PIAS3, ITGA6, TRAF1, E2F2, AKT1, CDKN2B, PIK3CB, E2F3, PTK2, CDK6, CKS1B, AKT2, TRAF2, PIAS4, PIK3CD, NFKB1",0.0716041477432862,0,FALSE +"H1299","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.35173,-1.3,0.128,15917,0.393,"STX3, STX19, SNAP23, BNIP1, STX17, SEC22B, SNAP47, GOSR2, STX12, GOSR1, VAMP8, VAMP5, BET1L, STX6",0.892790030352132,0.405607449624573,FALSE +"H1299","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.2691,-0.998,0.405,14043,0.705,"NEU4, GLA, KDSR, DEGS2, GAL3ST1, SGPP2, SMPD1, DEGS1, GBA, ACER3, PLPP3, GLB1, SGPL1, ARSA, ASAH1",0.392544976785331,0.151810883008601,FALSE +"H1299","Input","KEGG_SPLICEOSOME",0.49538,1.68,0.03,4233,0.411,"SNRPD2, SF3B5, SNRPC, BUD31, DHX16, DHX38, MAGOHB, HSPA1L, HSPA8, PUF60, WBP11, SNW1, RBM8A, HNRNPA1, SART1, HSPA1A, LSM7, ALYREF, HSPA1B, CTNNBL1, U2SURP, PRPF8, PRPF6, DDX39B, LSM2, XAB2, HNRNPM, RBM22, SNRPF, CDC40, PRPF31, TRA2B, HNRNPU, RBM25, SNRNP200, TCERG1, SF3B4, SRSF9, DHX15, SNRNP40, SYF2, ISY1, SNRPA, SNRPG, SNRPB, PPIL1, HNRNPK, DDX23, SF3A1, SF3A3, SF3A2, PRPF4, TXNL4A, SRSF1, HNRNPA3, CDC5L, LSM3, HSPA2, SNRPA1, U2AF1",1.52287874528034,0.386158178123931,FALSE +"H1299","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.17176,-0.624,0.969,9337,0.975,"UGT2B10, SI, AMY2B, UGT2B11, GBA3, UGT2B17, AMY1C, AMY1A, UGT2B4, UGDH, HK3, GAA, GBE1, UGP2, G6PC2, UGT2A1, UGT2A3, UGT2B15, MGAM, ENPP3, PYGM, TREH, HK2, UXS1, PGM2L1, UGT2B7, AGL, PGM1, GYS1, HK1",0.0136762229492347,0.0109953843014632,FALSE +"H1299","Input","KEGG_STEROID_BIOSYNTHESIS",-0.58004,-2.13,0.00831,15796,0.242,"DHCR7, NSDHL, DHCR24, LIPA, SC5D, MSMO1",2.08039897621589,0.616184634019569,TRUE +"H1299","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.30917,-1.12,0.27,14742,0.587,"AKR1C2, CYP3A7, CYP19A1, SRD5A1, UGT2B7, CYP1A1, CYP7B1, HSD17B2, CYP3A5, HSD11B2, SRD5A3, STS, AKR1C1, HSD17B12, AKR1C3",0.568636235841013,0.231361898752386,FALSE +"H1299","Input","KEGG_SULFUR_METABOLISM",-0.35104,-1.29,0.152,16556,0.388,"SULT1A2, BPNT1, SULT1A1",0.818156412055227,0.411168274405793,FALSE +"H1299","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.26652,-0.955,0.482,11568,0.719,"IL10, C5, FCGR2B, FCGR2C, ACTN2, C6, CD86, CTSG, GRIN2A, SNRPD3, TNF, FCGR1A, ELANE, FCGR2A, C2, SNRPD1, C3, TRIM21, C1S, C1R",0.31695296176115,0.143271109617117,FALSE +"H1299","Input","KEGG_TASTE_TRANSDUCTION",0.46914,1.62,0.0403,2683,0.394,"CACNA1A, SCNN1G, CACNA1B, TAS2R43, TAS2R8, SCNN1B, TAS2R14, TAS2R40, TAS2R46, TAS2R50, TAS2R19, GNB3, TAS2R20, TAS2R10",1.39469495385889,0.404503778174426,FALSE +"H1299","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.40719,1.4,0.088,1279,0.613,"CDO1, GAD1",1.05551732784983,0.212539525481585,FALSE +"H1299","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.34964,-1.25,0.198,16796,0.43,"MVK, HMGCS1, GGPS1",0.703334809738469,0.366531544420413,FALSE +"H1299","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.19662,-0.696,0.886,14662,0.983,"THBS2, CHRD, PPP2R1A, TNF, BMPR1A, RBL2, ACVRL1, CREBBP, RPS6KB2, THBS1, TGFBR1, INHBE, INHBB, BMP2, SMAD7, TFDP1, SKP1, INHBA, SMAD6, LTBP1, FST, BMP4, EP300, MAPK3, SMAD5",0.0525662781129492,0.00744648216786438,FALSE +"H1299","Input","KEGG_THYROID_CANCER",-0.35324,-1.29,0.149,17134,0.388,"PPARG, CDH1, RXRA, MAPK3, NCOA4",0.826813731587726,0.411168274405793,FALSE +"H1299","Input","KEGG_TIGHT_JUNCTION",0.18362,0.635,0.956,4356,1,"MYH15, PARD6A, CSNK2B, CLDN20, PPP2R2C, JAM3, AKT1, YBX3, RAB3B, PRKCG, CLDN15, EPB41L2, MPDZ, SYMPK, AKT2, RRAS, LLGL1, MYH10, MYL9, TJAP1, SPTAN1, MYH3, NRAS, ACTG1, CGN, MYL12A, GNAI2, PRKCZ, OCLN, MYL12B, PRKCE, AFDN, MAGI1",0.0195421077238999,0,FALSE +"H1299","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.29954,-1.09,0.295,16314,0.615,"CCL5, IL1B, TAB1, CHUK, TLR2, LY96, TLR4, TLR1, IRF5, MAPK13, IL6, TLR5, TIRAP, STAT1, CASP8, IKBKB, TOLLIP, TICAM2, MAP2K6, TLR3, CXCL8, MAPK3, IKBKE, FADD, MAP3K8, TRAF6, MYD88",0.530177984021837,0.211124884224583,FALSE +"H1299","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.43404,-1.61,0.0345,12346,0.283,"INMT, GCDH, CYP1B1, WARS2, ACMSD, DDC, MAOA, AANAT, ECHS1, AOC1, AADAT, EHHADH, IL4I1, IDO1, HAAO, KMO, MAOB, CYP1A1, HADH, TDO2, KYNU, CAT, ALDH2",1.46218090492673,0.54821356447571,FALSE +"H1299","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29037,1.01,0.402,403,1,"PIK3CG, CACNA1A, GCK, CACNA1B",0.39577394691553,0,FALSE +"H1299","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.25106,0.852,0.626,1279,1,"HSPD1, GAD1",0.20342566678957,0,FALSE +"H1299","Input","KEGG_TYROSINE_METABOLISM",-0.2501,-0.909,0.553,11110,0.756,"DBH, DCT, TAT, AOC3, COMT, TYR, AOC2, TPO, DDC, MAOA, ADH1C, TH, IL4I1, TYRP1, HEMK1, MAOB, ALDH3B2, HGD, GSTZ1, LCMT1, ALDH1A3, ALDH3A1, LCMT2",0.257274868695302,0.121478204498793,FALSE +"H1299","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.19907,0.686,0.907,2189,1,"PIK3CG, MAP3K14, PAK4, NFKBIB, FOS, PAK2, MAP3K7, MAPK11, AKT1, MAP2K2, MAPK12, NFKBIE, PIK3CB",0.0423927129399047,0,FALSE +"H1299","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.28473,-1.06,0.358,16976,0.634,"CDC16, TRIM32, KLHL9, FBXW8, UBOX5, ELOB, CBLC, CUL2, SKP1, ANAPC10, MGRN1, SIAH1, BTRC, UBE2I, XIAP, UBE2F, UBE2H, MID1, SYVN1, DET1, UBE2A, UBE2L6, CBLB, MAP3K1, UBA7, FBXW7, TRAF6, COP1, UBE2E1",0.446116973356126,0.197910742118267,FALSE +"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.62788,2.16,0.00314,4488,0.266,"VARS2, PDHB, BCAT1, PDHA1",2.50307035192679,0.575118363368933,FALSE +"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.43423,-1.52,0.0706,14291,0.302,"ECHS1, EHHADH, IL4I1, DBT, HIBCH, ACAA1, HADHB, HMGCL, OXCT1, MCCC1, HADH, HMGCS1, ABAT, ALDH6A1, ALDH2, PCCA, MCEE, HIBADH",1.1511952989482,0.519993057042849,FALSE +"H1299","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.19437,-0.708,0.879,14244,0.976,"ADRA1D, EDNRA, PRKCA, MYLK3, GUCY1A1, ITPR3, CALCRL, PLA2G10, MYL6, CACNA1D, PRKCH, ADCY4, ACTG2, CACNA1C, ADCY9, ITPR1, PRKCD, ADCY5, GNAQ, PRKACB, PPP1R12B, ADCY6, ADCY1, RAMP2, PLCB2, RAMP1, ADCY7, PLA2G4A, MAPK3, PLA2G12A, PPP1CB, ARAF",0.0560111249262281,0.0105501823333082,FALSE +"H1299","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.32427,-1.22,0.183,16749,0.468,"PRKACB, ADCY6, ARHGDIB, RAB5A, AQP3, CREB3L2, RAB5B, DYNLL2, DCTN5, DCTN6, RAB5C",0.737548910269571,0.329754146925876,FALSE +"H1299","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.20612,-0.741,0.801,16606,0.968,"PLCG2, SRC, NFATC2, PTGS2, MAPK13, PLA2G4A, MAPK3, VEGFA, RAC2, PLA2G12A, MAPKAPK2, PPP3CB",0.0963674839157623,0.0141246426916063,FALSE +"H1299","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.35939,-1.32,0.134,12681,0.396,"MUC2, CFTR, ATP6V0D1, ATP6V1G3, KCNQ1, PDIA4, ATP6V0D2, PRKCA, ATP6V1C2, ACTB, SLC12A2, ATP6V0A1, SEC61B, ADCY9, ATP6V1E1, ERO1A, ATP6V1A, ATP6V0A4, ATP6V1B2, ATP6V1G2, PLCG2, PRKACB, TJP2, ATP6V1B1, ATP6AP1, SEC61G, ATP6V0E1, KDELR2, ARF1",0.872895201635192,0.402304814074488,FALSE +"H1299","Input","KEGG_VIRAL_MYOCARDITIS",0.14034,0.481,1,3926,0.999,"MYH15, CD40, ICAM1, RAC3, MYH10, MYH3, ACTG1, EIF4G3, EIF4G1",0,0.000434511774017692,FALSE +"H1299","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.19241,-0.695,0.881,14778,0.975,"PPP2R1A, NKD1, FZD4, APC, WNT10A, WNT4, WNT7A, CREBBP, RAC1, CAMK2B, DAAM2, CTBP2, DVL3, MMP7, GSK3B, PRKACB, NFATC2, WNT11, LRP5, FRAT1, PORCN, PPARD, PLCB2, SKP1, NLK, PRICKLE2, WNT5A, VANGL2, SIAH1, BTRC, EP300, WNT7B, FRAT2, TBL1XR1, RAC2, DAAM1, PPP3CB",0.0550240915879521,0.0109953843014632,FALSE +"HCC44","Input","KEGG_ABC_TRANSPORTERS",-0.14437,-0.42,0.999,10995,0.999,"ABCC6, ABCB4, ABCA13, ABCB1, ABCG4, ABCA12, ABCD3, ABCA2, ABCB8, ABCC10, ABCB6, ABCB10, ABCD4, ABCB9",0.000434511774017692,0.000434511774017692,FALSE +"HCC44","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.39866,-1.16,0.22,14933,0.512,"MAPK1, LEF1, EIF4EBP1, PIK3CA, RPS6KB1, PIM1, TCF7L1, GRB2, KRAS, RELA, IKBKB, PML, SOS1, RPS6KB2, HRAS, MAPK3, PIK3R2, BAD",0.657577319177794,0.290730039024169,FALSE +"HCC44","Input","KEGG_ADHERENS_JUNCTION",-0.26087,-0.763,0.863,12186,1,"WASL, TCF7L2, NECTIN1, CSNK2A1, SSX2IP, PARD3, RAC3, CREBBP, RHOA, INSR, IQGAP1, LMO7, ACP1, SORBS1, CDC42, MAPK1, LEF1, WASF2, CTNND1, TCF7L1, WASF3, FARP2, PTPN1, ERBB2, SRC, MAPK3",0.0639892042847904,0,FALSE +"HCC44","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.26187,-0.764,0.84,11172,1,"PRKAB2, PRKAB1, TNFRSF1B, SLC2A4, MTOR, AKT2, PTPN11, PPARA, STK11, PRKCQ, AKT1, ACACB, RXRA, PPARGC1A, MAPK10, CPT1C, NFKBIE, ACSL3, MAPK9, CAMKK1, TRADD, CAMKK2, ADIPOR1, RXRB, RELA, IKBKB, CPT1B, ACSL1, PRKAG1",0.0757207139381184,0,FALSE +"HCC44","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.23418,-0.687,0.925,14681,1,"GPT, GFPT1, CPS1, ABAT, ALDH5A1, GLUL, NIT2, GOT1",0.0338582672609674,0,FALSE +"HCC44","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.27633,-0.811,0.795,8977,1,"PIK3CG, FXYD2, NEDD4L, PIK3R5, IGF1, HSD11B1, SCNN1G, ATP1B2, PIK3CD, KCNJ1, SCNN1A, PRKCA, SCNN1B, PIK3CB, PRKCG, PIK3R3, INSR, NR3C2, PIK3R1, MAPK1, PDPK1, PIK3CA, KRAS, MAPK3, PIK3R2",0.0996328713435297,0,FALSE +"HCC44","Input","KEGG_ALLOGRAFT_REJECTION",0.53632,1.94,0.02,362,0.14,"TNF, IL2, IL12B",1.69897000433602,0.853871964321762,TRUE +"HCC44","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.56047,-1.65,0.0147,17652,0.115,"PLA2G4B, PLA2G6, ACOX1, PLA2G12A",1.83268266525182,0.939302159646388,TRUE +"HCC44","Input","KEGG_ALZHEIMERS_DISEASE",-0.57556,-1.69,0.00741,15313,0.105,"GAPDH, LRP1, NDUFB2, PPP3CB, PPP3CC, PSEN2, UQCRC1, SDHB, APBB1, IDE, NDUFA9, ADAM10, NDUFS4, COX7B, NDUFV2, ATP5PF, GSK3B, NDUFS5, CASP3, NDUFA3, ATP5PB, NDUFB9, SDHD, SDHC, FADD, COX6B1, COX7A2L, UQCRQ, CALM2, UQCRFS1, APH1A, UQCRC2, CYC1, NDUFB7, CHP1, NDUFB1, UQCR11, ATP5PD, UQCRHL, ATP5F1E, NDUFA8, GNAQ, COX5A, NDUFA4, NDUFA10, NDUFS8, NDUFS2, COX7C, HSD17B10, NDUFV1, CDK5, NDUFB8, NDUFB4, NDUFC2, ATP5F1C, MAPK3, CALM3, CAPN1, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, COX6A1, PLCB3, NDUFA2, NDUFS3, APAF1, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, UQCRB, BAD, COX8A, NDUFB3",2.13018179202067,0.978810700930062,TRUE +"HCC44","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.50591,-1.48,0.0371,13716,0.199,"VARS2, EARS2, CARS2, TARS2, DARS2, FARS2, PARS2, IARS2, AARS2, SEPSECS, HARS2, MTFMT, NARS2",1.43062609038495,0.701146923590293,TRUE +"HCC44","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.47665,-1.4,0.0589,14409,0.26,"NPL, CMAS, GNE, GALK1, GPI, GFPT1, UXS1, CYB5R3, GMPPB, CYB5R1, GNPDA1, GALK2, AMDHD2, NAGK, PMM1, UGP2, GMPPA, MPI, GALT, FPGT",1.2298847052129,0.585026652029182,FALSE +"HCC44","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.40414,-1.19,0.183,14202,0.491,"MAPK14, DERL1, ALS2, BCL2L1, BAX, PPP3CB, PPP3CC, DAXX, TOMM40L, CAT, CASP3, MAP2K6, SOD1, CHP1, MAPK11, TP53, APAF1, CCS, BAD",0.737548910269571,0.308918507877032,FALSE +"HCC44","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.29309,1.12,0.208,1630,0.611,"KLRC2, CD74, HSPA6, KLRC3, HSPA1B, HSPA5, HSPA1A, IFNA1, PSME1, TAPBP, TAP2, LGMN",0.681936665037238,0.213958789757446,FALSE +"HCC44","Input","KEGG_APOPTOSIS",-0.27951,-0.821,0.774,14098,1,"PRKACA, PIK3R1, FAS, AIFM1, BCL2L1, PRKAR1A, BAX, PPP3CB, PPP3CC, PRKAR2B, TRADD, PIK3CA, CASP3, IRAK4, FADD, RELA, IKBKB, CHP1, ENDOG, PRKX, CASP6, TP53, PIK3R2, CAPN1, APAF1, BAD",0.111259039317107,0,FALSE +"HCC44","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.17975,-0.523,0.995,17627,1,"PTGES2, PLA2G4B, LTA4H, PLA2G6, PLA2G12A",0.00217691925427455,0,FALSE +"HCC44","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.29107,-0.857,0.708,11735,1,"GLUD1, GLUD2, GOT2, PYCR1, P4HA1, GLS2, ALDH18A1, GATM, ALDH7A1, CKMT1A, CKMT1B, PRODH, NOS3, SAT2, LAP3, CPS1, SMS, PYCR2, OAT, ALDH9A1, GLUL, AZIN2, GOT1, GAMT, PYCR3",0.149966742310231,0,FALSE +"HCC44","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.20439,-0.592,0.973,9327,1,"LAMA2, SGCG, CACNA2D3, ITGA11, SGCB, CTNNA2, CTNNA1, SGCD, SGCA, CACNG7, ITGA10, CACNA1C, CACNB2, ITGA9, ACTN2, CACNA2D2, ITGA6, RYR2, DAG1, CACNG6, TCF7L2, CACNA1D, CACNB4, CACNG8, ITGA4, ITGB6, ITGA2B, SLC8A1, LMNA, CACNG4, LEF1, ITGA7, CACNA2D1, PKP2, DMD, ITGB8, EMD, CDH2, TCF7L1, CACNB3",0.0118871597316481,0,FALSE +"HCC44","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.15866,-0.472,0.999,16830,1,"ALDH9A1",0.000434511774017692,0,FALSE +"HCC44","Input","KEGG_ASTHMA",0.44335,1.77,0,2492,0.191,"TNF, IL13, CD40, PRG2, FCER1A",Inf,0.718966632752272,TRUE +"HCC44","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.33423,1.26,0.15,9163,0.503,"IL2, IFNA1, CD40, IFNA4, IFNA17, IFNA6, IFNA16, CD28, FASLG, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, CD80, IL10, TSHB, IFNA13, IL4, CTLA4, CD86, IFNA21, CGA, PRF1, IFNA8, GZMB, TPO, IFNA5, TSHR",0.823908740944319,0.298432014944073,FALSE +"HCC44","Input","KEGG_AXON_GUIDANCE",-0.3119,-0.918,0.612,11084,0.981,"EPHB1, NRAS, CXCL12, ROBO2, PLXNB1, GNAI2, EPHA3, NTN1, DPYSL5, ABLIM2, SEMA3C, EPHA6, SEMA6D, UNC5A, ARHGEF12, UNC5B, NGEF, ROBO1, FES, SLIT3, SEMA6A, EFNA2, RAC3, RHOA, EPHB4, SLIT2, CXCR4, SEMA3D, NFATC3, SEMA4A, SEMA3E, PLXNB2, EFNB3, PLXNB3, PTK2, SEMA5A, GNAI3, PAK4, EPHA1, ROBO3, CDC42, SEMA6C, MAPK1, RASA1, PAK6, NFATC4, EFNB1, PPP3CB, SEMA4D, PPP3CC, SEMA4C, SRGAP3, SEMA4G, DPYSL2, EPHA4, EPHB3, GSK3B, PAK1, EFNA4, RGS3, KRAS, LIMK2, EFNA3, CHP1, NCK2, SEMA4F, CFL1, CDK5, HRAS, MAPK3, SRGAP2",0.213248577854439,0.0083309926200515,FALSE +"HCC44","Input","KEGG_BASAL_CELL_CARCINOMA",-0.29998,-0.877,0.681,12191,1,"HHIP, FZD8, WNT4, TCF7L2, PTCH1, FZD3, WNT10A, FZD7, AXIN2, WNT10B, GLI1, BMP4, FZD4, LEF1, DVL3, APC, FZD2, GSK3B, AXIN1, STK36, TCF7L1, DVL2, SMO, SUFU, TP53",0.166852888087215,0,FALSE +"HCC44","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.40519,-1.19,0.212,13676,0.491,"TBPL1, GTF2E1, TAF11, TAF2, TAF7, TAF9B, STON1, GTF2E2, GTF2B, TAF6, TAF10, TAF1, TAF6L, TAF5, GTF2A2",0.673664139071249,0.308918507877032,FALSE +"HCC44","Input","KEGG_BASE_EXCISION_REPAIR",-0.57625,-1.69,0.00953,12329,0.105,"NEIL1, XRCC1, APEX1, PARP2, POLD1, POLE, PCNA, LIG3, POLE4, MUTYH, FEN1, PARP3, APEX2, POLD3, SMUG1, POLD4, MPG, NEIL3, UNG, LIG1, POLL, NEIL2, OGG1, NTHL1, POLB",2.02090709936167,0.978810700930062,TRUE +"HCC44","Input","KEGG_BETA_ALANINE_METABOLISM",-0.40672,-1.19,0.187,15448,0.491,"ABAT, SMS, HADHA, EHHADH, ALDH9A1, ECHS1, HIBCH",0.728158393463501,0.308918507877032,FALSE +"HCC44","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.44375,-1.28,0.118,13525,0.367,"HSD17B12, ELOVL2, HACD2, ACOT7, TECR, ACAA1, HADHA, SCD5, ACOX1, PECR",0.928117992693875,0.435333935747911,FALSE +"HCC44","Input","KEGG_BLADDER_CANCER",-0.31503,-0.918,0.598,14933,0.981,"MAPK1, CDK4, DAPK1, MDM2, KRAS, E2F1, E2F2, ERBB2, HRAS, TP53, MAPK3, VEGFB",0.223298816011589,0.0083309926200515,FALSE +"HCC44","Input","KEGG_BUTANOATE_METABOLISM",-0.49672,-1.45,0.041,12914,0.211,"L2HGDH, BDH2, ALDH7A1, AACS, ACAT2, ABAT, ALDH5A1, HADHA, EHHADH, HMGCL, ALDH9A1, HMGCS1, PDHB, ECHS1, ACADS, HADH, PDHA1, ACAT1",1.38721614328026,0.675717544702307,TRUE +"HCC44","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.31521,-0.922,0.61,11376,0.99,"PIK3CB, CD81, BLNK, BCL10, VAV2, MAP2K1, AKT2, INPP5D, PIK3R3, RAC3, SOS2, IFITM1, AKT1, NFATC3, SYK, PIK3AP1, PIK3R1, LILRB3, MAPK1, VAV3, CD72, NFATC4, NFKBIE, PPP3CB, PPP3CC, PLCG2, PIK3CA, GSK3B, GRB2, KRAS, RELA, IKBKB, CHP1, SOS1, HRAS, MAPK3, PIK3R2",0.214670164989233,0.00436480540245009,FALSE +"HCC44","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.19988,-0.582,0.983,12473,1,"F2R, P2RX6, PDE1C, PRKCG, PLCD4, CAMK2B, RYR1, ATP2A1, CACNA1D, CACNA1H, PDGFRB, TBXA2R, CALML6, ADRA1B, TNNC1, CHRM3, PRKACA, CALM1, SLC8A1, CHRNA7, VDAC1, PLCB4, NOS3, GNA11, CAMK4, PHKB, GNAL, ERBB3, PPID, ITPKA, P2RX4, PHKG2, PPP3CB, PPP3CC, PLCG2, CAMK2D, ITPKB, VDAC2, ADCY9, SLC25A4, PHKA2, CAMK2G, CALM2, SLC25A6, CHP1, ERBB2, PLCD1, PLCG1, GNAQ, PRKX, SPHK2, VDAC3, CALM3, PLCB3",0.00744648216786438,0,FALSE +"HCC44","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.44629,-1.3,0.11,13704,0.35,"TNNC1, CACNB4, CACNG8, UQCRH, COX7A2, SLC8A1, TNNI3, CACNG4, CACNA2D1, UQCRC1, COX7B, SLC9A6, TPM3, COX6B1, COX7A2L, UQCRQ, UQCRFS1, UQCRC2, CYC1, UQCR11, UQCRHL, COX5A, COX7C, UQCR10, COX6A1, CACNB3, COX5B, COX6C, UQCRB, COX8A",0.958607314841775,0.455931955649724,FALSE +"HCC44","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.18511,0.738,0.945,1943,0.914,"ITGB2, CD274, PVR, ICAM1, PDCD1LG2, ICAM2, SELPLG, CLDN1, PTPRF, CD58, NEGR1, SDC4, ITGAV, ALCAM, ITGB1, CD40, CLDN4",0.0245681914907371,0.0390538042661686,FALSE +"HCC44","Input","KEGG_CELL_CYCLE",-0.50846,-1.49,0.0341,12645,0.194,"TFDP2, STAG2, DBF4, ANAPC4, ORC5, TGFB3, SKP2, RBL2, CREBBP, PTTG2, CDK7, CDC14B, ANAPC1, ORC6, MAD2L2, RBL1, CDC26, ANAPC10, CHEK2, MCM4, BUB3, HDAC1, PCNA, YWHAQ, WEE1, ZBTB17, MCM2, CDK2, CDC20, CCND3, SMC1A, MCM6, CDC14A, CDK4, YWHAH, ANAPC5, ANAPC7, SKP1, MCM3, YWHAE, GSK3B, CDKN2C, PTTG1, MDM2, CDC45, ORC2, CCNB1, MCM5, YWHAZ, CDKN1B, ANAPC11, FZR1, SMC3, CDC23, ORC3, ORC4, E2F1, TTK, ORC1, CHEK1, E2F2, CDC27, CDC25B, PLK1, CCNA2, YWHAB, BUB1, CCNB2, MAD2L1, CDKN2D, TP53, CDK1, BUB1B, ESPL1, RBX1, CDC25C, RAD21, PKMYT1",1.4672456210075,0.712198270069774,TRUE +"HCC44","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.19876,-0.59,0.973,11825,1,"ADCY5, VAV2, MAP2K1, PREX1, JAK3, PRKCD, AKT2, CXCR6, WASL, GRK7, GRK4, GNG2, GNG13, GNG5, CCL28, PIK3R3, PARD3, SHC3, CCL27, SOS2, RHOA, GNG7, GNB5, SHC2, CXCR4, AKT1, RASGRP2, CCL2, PRKACA, TIAM2, PIK3R1, RAP1A, PTK2, PLCB4, GNAI3, PRKCZ, ADCY6, CDC42, MAPK1, VAV3, CCR10, GRK5, CRKL, PIK3CA, ARRB1, GSK3B, ADCY9, STAT1, GRK2, PAK1, GRB2, KRAS, RELA, STAT2, IKBKB, GNB2, SOS1, GRK6, PRKX, ARRB2, HRAS, CSK, MAPK3, PIK3R2, PLCB3",0.0118871597316481,0,FALSE +"HCC44","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.37997,-1.11,0.29,12387,0.605,"ARAF, PTPN11, PIK3R3, SHC3, SOS2, TGFB3, CBLC, SHC2, AKT1, CTBP2, PIK3R1, HDAC1, CBL, BCR, MAPK1, BCL2L1, CDK4, CRKL, PIK3CA, GAB2, MDM2, CDKN1B, GRB2, KRAS, RELA, E2F1, IKBKB, E2F2, SOS1, CTBP1, HRAS, TP53, MAPK3, PIK3R2, BAD",0.537602002101044,0.218244625347531,FALSE +"HCC44","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.19943,-0.584,0.976,17357,1,"CRY2",0.0105501823333082,0,FALSE +"HCC44","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.52036,-1.55,0.0203,14250,0.153,"DLAT, OGDH, OGDHL, SUCLA2, IDH2, SDHB, FH, SDHD, SDHC, PDHB, IDH1, IDH3A, MDH1, ACO2, PDHA1, SUCLG1",1.69250396208679,0.815308569182401,TRUE +"HCC44","Input","KEGG_COLORECTAL_CANCER",-0.36807,-1.09,0.31,12342,0.635,"TCF7L2, ARAF, PIK3R3, CASP9, RAC3, MLH1, BCL2, TGFB3, RHOA, AXIN2, AKT1, MSH3, PIK3R1, APPL1, MAPK10, RALGDS, MSH6, MAPK1, LEF1, BAX, APC, MAPK9, PIK3CA, GSK3B, AXIN1, CASP3, TCF7L1, KRAS, BIRC5, TP53, MAPK3, PIK3R2, BAD",0.508638306165727,0.197226274708024,FALSE +"HCC44","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.43012,1.62,0.0638,1345,0.285,"THBD, CFB, PLAUR, C3, F3, SERPINE1, BDKRB1, TFPI, PLAU, C1S, CD55, C4A, BDKRB2",1.19517932127884,0.54515513999149,FALSE +"HCC44","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.31599,-0.917,0.606,15274,0.974,"MTR, LDHA, SMS, ADI1, DNMT3B, DNMT3A, ENOPH1, MPST, GOT1, MAT2B",0.217527375833714,0.0114410431213845,FALSE +"HCC44","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.42205,1.48,0.0769,1980,0.309,"OSM, TNFRSF9, TNFSF11, IL24, IL11, CSF3, CXCL5, TNFRSF18, TNFRSF6B, CXCL6, TNF, CXCL8, IL2, IFNE, CSF2, CXCL2, CCL20, VEGFC, CCL5, CXCL3, IL12B, IL6, TGFB2, BMP2, TNFRSF10D, IL1B, IL15RA, TNFRSF25, IL1A, IL13, TNFRSF10A, INHBE, IL6ST, TGFBR1, CSF1, IL20RB, CCL26, CLCF1, IL6R, IL7R, TNFSF14, CD70, OSMR, CXCR3, IFNA1, XCL1, TNFSF9, TGFB1, KITLG, TNFRSF4, CX3CL1, LTB, IFNGR1, TGFBR2, EGFR, PF4V1, IL2RG, VEGFA, RELT, IL22, TNFRSF12A, MET, IL1RAP, CXCL1, CD40, IL7, IL23A",1.11407366019857,0.510041520575165,FALSE +"HCC44","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.22063,0.811,0.698,1635,0.848,"CCL5, IL6, IL1B, RIPK1, AIM2, IFNA1, NFKB1, NFKBIA, IKBKG",0.156144577376839,0.0716041477432862,FALSE +"HCC44","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.16076,-0.463,0.999,9251,1,"MYL2, LAMA2, SGCG, CACNA2D3, ADCY4, ITGA11, IGF1, SGCB, TPM1, SGCD, SGCA, CACNG7, ITGA10, CACNA1C, ADRB1, CACNB2, ITGA9, CACNA2D2, ITGA6, ADCY5, RYR2, DAG1, CACNG6, TNNT2, CACNA1D, TGFB3, TNNC1, CACNB4, CACNG8, ITGA4, ITGB6, PRKACA, ITGA2B, SLC8A1, LMNA, TNNI3, CACNG4, ADCY6, ITGA7, CACNA2D1, DMD, ITGB8, EMD, ADCY9, TPM3, PRKX, CACNB3",0.000434511774017692,0,FALSE +"HCC44","Input","KEGG_DNA_REPLICATION",-0.58861,-1.7,0.00848,13452,0.114,"POLD1, POLA1, POLE, MCM4, RPA3, PCNA, MCM2, RFC4, MCM6, RFC2, POLE4, RPA2, MCM3, FEN1, RNASEH2A, POLD3, MCM5, RPA1, RFC5, POLD4, PRIM2, LIG1, DNA2, RNASEH2C, POLA2",2.07160414774329,0.943095148663527,TRUE +"HCC44","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.36954,-1.06,0.359,11539,0.68,"NOTCH4, MAP2K1, SPIRE2, NOTCH3, SOS2, FMN2, CPEB1, MAPK1, GRB2, KRAS, SOS1, MAPK3",0.444905551421681,0.167491087293764,FALSE +"HCC44","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.19587,-0.573,0.983,5790,1,"UGT2B11, GSTA3, CYP2A7, UGT2B4, CYP2A13, FMO2, ADH1B, ADH7, ADH4, UGT2B17, CYP1A2, FMO1, ADH1A, CYP3A43, UGT2A3, GSTM5, CYP2C19, UGT2B15, CYP2A6, GSTA2, FMO3, CYP2B6, ADH1C, CYP2C9, GSTK1, CYP2C18, CYP2C8, GSTA1, GSTM4, ADH6, MGST2, MAOA, CYP3A5, CYP3A7, CYP3A4, MAOB, UGT2B7, ALDH3B2, CYP2E1, CYP2D6, GSTM1, GSTM2, GSTT2, FMO5, GSTO1, GSTP1, FMO4, GSTA4, ADH5, MGST3",0.00744648216786438,0,FALSE +"HCC44","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.20452,-0.602,0.965,18592,1,"UCK1, TK1",0.0154726866562074,0,FALSE +"HCC44","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.26823,0.972,0.333,1952,0.725,"COL4A6, ITGA2, AGRN, TNXB, LAMC2, LAMB3, ITGA1, ITGA5, HSPG2, COL4A2, COL4A1, COL5A1, LAMB1, COL6A2, LAMA5, SDC4, LAMA3, COL6A1, THBS1, RELN, ITGAV, ITGB1, CD44, ITGA3",0.47755576649368,0.139661993429006,FALSE +"HCC44","Input","KEGG_ENDOCYTOSIS",-0.43834,-1.28,0.116,13127,0.367,"ITCH, CBLC, SH3GL3, CLTB, VPS37B, AP2M1, ACAP1, RAB5A, CXCR4, RAB11FIP5, RAB11FIP3, HSPA1L, CHMP2B, PIP5K1A, AP2A1, EPN3, CBL, RUFY1, PARD6G, CLTC, PDCD6IP, WWP1, DNM3, EEA1, PRKCZ, IQSEC1, RAB4A, MVB12A, CDC42, FGFR2, ERBB3, SH3GLB1, VPS4A, RAB5C, VPS37C, FGFR4, SH3GL1, GRK5, RBSN, PIP4K2B, USP8, PSD, PARD6B, EPN1, ARRB1, RAB11FIP4, CHMP4B, CHMP2A, PARD6A, MDM2, RAB11B, AGAP1, GRK2, STAM2, SH3GLB2, VPS25, STAMBP, IQSEC2, MVB12B, VPS37A, VPS37D, CLTA, PIKFYVE, RNF41, ASAP3, TSG101, SRC, GIT2, SMAP1, CHMP3, GRK6, DNM1L, GIT1, SNF8, CHMP5, ARRB2, HRAS, EPS15, ARFGAP2, PLD2, ARAP1, VPS28, RAB5B, RAB11A",0.935542010773082,0.435333935747911,FALSE +"HCC44","Input","KEGG_ENDOMETRIAL_CANCER",-0.44413,-1.3,0.111,11157,0.35,"NRAS, APC2, EGF, FOXO3, PIK3CB, MAP2K1, AKT2, TCF7L2, ARAF, PIK3R3, CASP9, MLH1, SOS2, AXIN2, AKT1, PIK3R1, MAPK1, PDPK1, LEF1, APC, PIK3CA, ELK1, GSK3B, AXIN1, TCF7L1, GRB2, KRAS, ERBB2, SOS1, ILK, HRAS, TP53, MAPK3, PIK3R2, BAD",0.954677021213343,0.455931955649724,FALSE +"HCC44","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.43152,-1.26,0.142,14005,0.391,"JAM3, MAPK14, ATP6V0D1, MAPK10, ATP6V0B, ATP6V1G1, ATP6V0A1, ATP6V1G2, CDC42, ATP6V1B1, ATP6V0E2, PLCG2, MAPK9, ADAM10, ATP6V1A, ATP6V1H, ATP6V0C, CASP3, ATP6V1B2, PAK1, RELA, ATP6V1E1, IKBKB, ATP6V0E1, ATP6V1E2, MAPK11, SRC, PLCG1, ATP6V1C1, GIT1, CSK, ATP6V1F",0.847711655616944,0.407823242604133,FALSE +"HCC44","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.39089,-1.14,0.246,12707,0.539,"PRKCG, PIK3R3, CAMK2B, SHC3, SOS2, CBLC, SHC2, AKT1, MAP2K7, PIK3R1, PTK2, MAPK10, NRG2, CBL, NRG4, PAK4, MAPK1, ERBB3, PAK6, EIF4EBP1, PLCG2, CRKL, MAPK9, CAMK2D, PIK3CA, ELK1, GSK3B, RPS6KB1, GAB1, PAK1, CDKN1B, CAMK2G, GRB2, KRAS, ERBB2, SOS1, NCK2, SRC, PLCG1, RPS6KB2, HRAS, MAPK3, PIK3R2, BAD",0.609064892896621,0.268411234813261,FALSE +"HCC44","Input","KEGG_ETHER_LIPID_METABOLISM",-0.40118,-1.18,0.214,17652,0.491,"PLA2G4B, PAFAH1B3, PLA2G6, PAFAH2, PLD2, PLA2G12A",0.669586226650809,0.308918507877032,FALSE +"HCC44","Input","KEGG_FATTY_ACID_METABOLISM",-0.53442,-1.56,0.0303,14150,0.163,"ECI1, ACADM, ACAT2, CPT1C, ACAA1, ACSL3, HADHA, EHHADH, GCDH, ALDH9A1, ECHS1, ACADS, CPT1B, ACOX1, ACADSB, HADHB, ACSL1, HADH, ADH5, ACAT1",1.5185573714977,0.787812395596042,TRUE +"HCC44","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.29177,-0.849,0.719,13644,1,"AKT1, SYK, MAP2K7, PIK3R1, MAPK14, MAPK10, MAPK1, VAV3, PDPK1, PLCG2, MAPK9, PIK3CA, GAB2, MAP2K6, GRB2, KRAS, PLA2G4B, SOS1, PLA2G6, MAPK11, PLCG1, HRAS, MAPK3, PIK3R2, PLA2G12A",0.143271109617117,0,FALSE +"HCC44","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.37069,-1.08,0.343,11163,0.647,"ARPC1A, PLA2G4F, FCGR2A, PIK3CB, WAS, DNM2, VAV2, MAP2K1, PRKCD, AKT2, WASL, SCIN, INPP5D, PRKCG, PIK3R3, MARCKSL1, MARCKS, PLPP1, AKT1, SYK, PIP5K1A, PIK3R1, VASP, ARPC4, DNM3, CDC42, MAPK1, VAV3, PLCG2, CRKL, PIP4K2B, PIK3CA, WASF2, GAB2, RPS6KB1, WASF3, PAK1, ARPC5, LIMK2, ARPC2, PIKFYVE, ASAP3, PLA2G4B, PLA2G6, PLCG1, GSN, RPS6KB2, DNM1L, SPHK2, CFL1, MAPK3, PIK3R2, PLD2, ARPC3",0.464705879957229,0.1890957193313,FALSE +"HCC44","Input","KEGG_FOCAL_ADHESION",-0.20819,-0.61,0.969,10402,1,"COL6A3, PAK3, VEGFD, XIAP, RASGRF1, CAV1, MYLK3, MAPK8, ROCK1, ITGA10, LAMC3, PTEN, ARHGAP35, COL11A1, COL5A3, PXN, MYL9, MYLK2, ITGA9, ACTN2, EGF, PIK3CB, FLT4, COL1A1, ITGA6, VAV2, MAP2K1, AKT2, THBS2, COL3A1, CCND2, LAMA1, PRKCG, PIK3R3, RAC3, SHC3, SOS2, BCL2, COL11A2, PDGFRB, RHOA, COL1A2, MYLPF, PGF, PDGFC, SHC2, AKT1, TLN1, ITGA4, SPP1, ITGB6, THBS4, ITGA2B, CHAD, PIK3R1, RAP1A, MYL5, VASP, PTK2, MAPK10, PDGFD, PPP1CC, PAK4, CDC42, PDGFB, LAMA4, MAPK1, VAV3, PDPK1, CCND3, COL5A2, PAK6, ITGA7, FN1, CRKL, MAPK9, ITGB8, THBS3, PIK3CA, ELK1, GSK3B, RAPGEF1, PAK1, GRB2, ERBB2, SOS1, ILK, SRC, TLN2, PPP1CB, HRAS, MAPK3, PIK3R2, VEGFB, PPP1CA, BAD",0.0136762229492347,0,FALSE +"HCC44","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.47339,-1.39,0.0557,14562,0.268,"GGH, QDPR, FPGS, SPR, DHFR",1.25414480482627,0.571865205971211,FALSE +"HCC44","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.48366,-1.41,0.0647,15857,0.261,"PHPT1, GMPPB, MTMR6, TPI1, PFKL, ALDOA, PMM1, KHK, GMPPA, MPI, FPGT",1.1890957193313,0.583359492661719,FALSE +"HCC44","Input","KEGG_GALACTOSE_METABOLISM",-0.44266,-1.3,0.113,11743,0.35,"GCK, PGM1, PGM2, HK1, GALE, PFKM, GALK1, B4GALT2, GAA, GLA, GALK2, PFKL, UGP2, GALT, GANC",0.94692155651658,0.455931955649724,FALSE +"HCC44","Input","KEGG_GAP_JUNCTION",-0.34838,-1.01,0.438,10956,0.806,"DRD2, ADRB1, NRAS, EGF, TUBB8, GNAI2, GUCY1A2, ADCY5, TUBB2A, MAP2K1, PRKG1, PRKCG, GUCY1A1, SOS2, PDGFRB, PDGFC, TUBB4A, TUBA1A, PRKACA, PDGFD, GUCY1B1, PLCB4, GNAI3, TUBB2B, GNA11, ADCY6, PDGFB, MAPK1, MAP3K2, TUBB4B, TUBB, MAPK7, TUBA1B, ADCY9, GRB2, KRAS, SOS1, SRC, MAP2K5, GNAQ, PRKX, HRAS, CDK1, MAPK3, PLCB3",0.3585258894959,0.0936649581949093,FALSE +"HCC44","Input","KEGG_GLIOMA",-0.39728,-1.16,0.243,11127,0.512,"RB1, NRAS, EGF, PIK3CB, MAP2K1, MTOR, AKT2, ARAF, PRKCG, PIK3R3, CAMK2B, SHC3, SOS2, PDGFRB, SHC2, CALML6, AKT1, PIK3R1, CALM1, PDGFB, MAPK1, CDK4, PLCG2, CAMK2D, PIK3CA, MDM2, CAMK2G, GRB2, KRAS, E2F1, CALM2, E2F2, SOS1, PLCG1, HRAS, TP53, MAPK3, PIK3R2, CALM3",0.614393726401688,0.290730039024169,FALSE +"HCC44","Input","KEGG_GLUTATHIONE_METABOLISM",-0.28621,-0.833,0.743,12431,1,"GPX7, GSTM2, GPX2, OPLAH, GPX4, GSTT2, GSTO1, RRM1, LAP3, IDH2, GSTP1, TXNDC12, SMS, RRM2, GSS, IDH1, RRM2B, GSTA4, MGST3",0.129011186239425,0,FALSE +"HCC44","Input","KEGG_GLYCEROLIPID_METABOLISM",0.26218,0.996,0.4,1263,0.704,"GPAT2, AKR1B1, DGKH, GPAT3, PLPP3, DGKG, DGKE, DGAT2, DGKD, GK, DGKI",0.397940008672038,0.152427340857888,FALSE +"HCC44","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.28063,-0.827,0.779,11448,1,"GPD1, PHOSPHO1, AGPAT3, CHKA, PLA2G10, PCYT1A, PCYT1B, LPCAT3, CDS1, PGS1, LCLAT1, PLPP1, LPCAT4, GPD2, PLA2G15, AGPAT2, ACHE, MBOAT1, ETNK1, LYPLA1, PTDSS2, DGKZ, GNPAT, LPGAT1, DGKQ, ETNK2, DGKA, CHKB, PLA2G4B, PLA2G6, PCYT2, CDS2, LYPLA2, PLD2, PLA2G12A, CDIPT",0.108462542327436,0,FALSE +"HCC44","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.28303,-0.83,0.78,10800,1,"MAOA, MAOB, SHMT2, GNMT, SARDH, DLD, PSPH, PIPOX, GCAT, GATM, GLYCTK, SRR, GLDC, AMT, PHGDH, ALAS1, SHMT1, GAMT",0.10790539730952,0,FALSE +"HCC44","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.4332,-1.26,0.144,13390,0.391,"PGK1, ALDH7A1, PFKM, DLAT, BPGM, GALM, PGAM4, GPI, GAPDH, LDHA, AKR1A1, ENO3, TPI1, ALDH9A1, ACSS1, PKM, PDHB, PFKL, ALDOA, ACSS2, PGAM1, PDHA1, ADH5",0.84163750790475,0.407823242604133,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.33629,1.24,0.167,750,0.498,"CSGALNACT1, CHSY1, B3GALT6, CHST11, CHPF2, DSE",0.777283528852417,0.302770657240282,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.25001,-0.735,0.897,11027,1,"NDST3, B3GAT1, GLCE, EXT2, HS3ST3A1, NDST1, XYLT1, HS3ST3B1, EXTL3, B4GALT7, HS6ST1, XYLT2, NDST2, B3GAT3",0.0472075569559079,0,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.29609,-0.875,0.685,13130,1,"B3GNT7, CHST6, B4GALT2, B4GALT3, B4GAT1, B4GALT4",0.164309428507574,0,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.34584,-1.01,0.427,11770,0.806,"IDUA, HYAL1, HS3ST3A1, HYAL2, HS3ST3B1, HEXB, GALNS, HYAL3",0.369572124974976,0.0936649581949093,FALSE +"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.26843,1.03,0.333,13985,0.699,"ST3GAL1, SLC33A1, ST3GAL2, GLB1, ST6GALNAC4, ST3GAL5, HEXA, ST8SIA5, ST6GALNAC6, B4GALNT1, ST6GALNAC5, ST6GALNAC3, ST8SIA1, B3GALT4, HEXB",0.47755576649368,0.155522824254319,FALSE +"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.27799,-0.815,0.778,10376,1,"FUT9, FUT2, FUT1, GBGT1, ST8SIA1, HEXB, GLA, NAGA",0.109020403010311,0,FALSE +"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.21628,-0.636,0.961,9786,1,"B3GNT2, B3GALT2, FUT9, ST3GAL6, FUT2, FUT1, ABO, B3GALT1, FUT3, ST8SIA1, B4GALT2, B3GNT4, B4GALT3, B4GAT1, B4GALT4",0.0172766123314547,0,FALSE +"HCC44","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.53049,-1.55,0.0201,12054,0.153,"PIGB, PIGP, PIGZ, PIGN, PIGT, PIGA, PIGG, PIGK, PIGO, GPLD1, DPM2, PGAP1, PIGM, PIGF, PIGQ, PIGC, PIGV, PIGU, GPAA1",1.69680394257951,0.815308569182401,TRUE +"HCC44","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.4592,-1.34,0.0813,12685,0.321,"AFMID, ACO1, GLYCTK, CS, GRHPR, PGP, MDH1, ACO2",1.08990945440593,0.493494967595128,FALSE +"HCC44","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.40387,-1.18,0.201,13640,0.491,"CALML6, ATF4, MAP2K7, PRKACA, MAPK14, MAPK10, CALM1, PLCB4, GNA11, MAP3K1, ADCY6, CDC42, MAPK1, MAP3K2, MAPK9, CAMK2D, MAP3K3, MAPK7, ELK1, ADCY9, GNRH1, MAP2K6, CAMK2G, GRB2, KRAS, CALM2, PLA2G4B, SOS1, PLA2G6, MAPK11, SRC, GNAQ, PRKX, HRAS, MAPK3, PLD2, CALM3, PLA2G12A, PLCB3",0.696803942579511,0.308918507877032,FALSE +"HCC44","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.6556,2.33,0,565,0.0672,"TNF, IL2, IL6, IL1B, IL1A",Inf,1.17263072694617,TRUE +"HCC44","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.2018,-0.588,0.981,12191,1,"HHIP, WNT4, PTCH1, CSNK1G2, WNT10A, CSNK1G3, GAS1, WNT10B, BMP7, GLI1, PRKACA, BMP4, FBXW11, CSNK1G1, GSK3B, STK36, SMO, PRKX, BTRC, SUFU",0.0083309926200515,0,FALSE +"HCC44","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.41787,1.51,0.0678,1254,0.32,"IL11, CSF3, CD38, TNF, CSF2, ITGA2, IL6, IL1B, IL1A, ITGA1, CSF1, ITGA5, IL6R, IL7R, CD55, KITLG, TFRC",1.16877030613294,0.494850021680094,FALSE +"HCC44","Input","KEGG_HISTIDINE_METABOLISM",-0.28659,-0.834,0.751,10163,1,"AMDHD1, AOC1, MAOA, MAOB, ALDH3B2, ACY3, FTCD, ALDH7A1, LCMT2, ALDH9A1, HEMK1, LCMT1",0.124360062995832,0,FALSE +"HCC44","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.64738,-1.91,0.00106,15780,0.0735,"BRCA2, RAD52, RPA2, MRE11, POLD3, RPA1, POLD4, RAD51C, EME1, BLM, RAD54L, MUS81, RAD51, RAD54B, SEM1",2.97469413473523,1.1337126609158,TRUE +"HCC44","Input","KEGG_HUNTINGTONS_DISEASE",-0.57084,-1.66,0.0148,16086,0.114,"NDUFA9, NDUFS4, COX7B, POLR2E, CREB1, NDUFV2, ATP5PF, VDAC2, NDUFS5, CASP3, SLC25A4, NDUFA3, ATP5PB, POLR2J, NDUFB9, SDHD, SOD1, SDHC, COX6B1, COX7A2L, POLR2F, UQCRQ, CLTA, UQCRFS1, CREB3L4, UQCRC2, CYC1, DCTN2, SLC25A6, NDUFB7, NDUFB1, UQCR11, POLR2K, ATP5PD, UQCRHL, ATP5F1E, NDUFA8, GNAQ, COX5A, DNAL4, NDUFA4, NDUFA10, NDUFS8, CREB3, NDUFS2, COX7C, POLR2G, NDUFV1, NDUFB8, VDAC3, NDUFB4, TP53, NDUFC2, ATP5F1C, DCTN1, POLR2L, SP1, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, COX6A1, PLCB3, NDUFA2, NDUFS3, SIN3A, APAF1, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, UQCRB, COX8A, NDUFB3",1.82973828460504,0.943095148663527,TRUE +"HCC44","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.17222,0.697,0.863,1065,0.915,"CACNA2D4, TNF, ITGA2, IL6, TGFB2, ITGA1, ITGA5, TPM4, TGFB1",0.0639892042847904,0.0385789059335517,FALSE +"HCC44","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.47716,-1.4,0.0596,14947,0.26,"PIP4K2C, INPP5K, ITPKA, PLCG2, INPP4B, PIP4K2B, PI4KB, ITPKB, IPMK, PIK3CA, PI4KA, INPP5E, TPI1, PIKFYVE, INPPL1, INPP4A, PIK3C2B, PLCD1, PLCG1, CDIPT, PLCB3, INPP5B",1.22475374025976,0.585026652029182,FALSE +"HCC44","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.42708,-1.25,0.142,11029,0.405,"PDE3A, RPTOR, NRAS, PRKAB2, FBP2, PRKAB1, PIK3CB, PRKCI, SLC2A4, GCK, MAP2K1, MTOR, SH2B2, AKT2, PRKAR2A, ARAF, INPP5D, PIK3R3, PPP1R3D, HK1, SHC3, SOS2, PDE3B, CBLC, FLOT2, INSR, TRIP10, FASN, SHC2, CALML6, AKT1, ACACB, TSC1, PPARGC1A, PRKACA, PIK3R1, MAPK10, CALM1, SORBS1, CBL, PPP1CC, LIPE, PHKB, PRKCZ, MAPK1, PDPK1, PRKAR1A, INPP5K, EIF4EBP1, EIF4E, PHKG2, PRKAR2B, CRKL, TSC2, MAPK9, PIK3CA, ELK1, FLOT1, GSK3B, RPS6KB1, MKNK1, RAPGEF1, PHKA2, GRB2, GYS1, KRAS, CALM2, PTPN1, IKBKB, EXOC7, SOS1, RPS6KB2, PRKX, PPP1CB, HRAS, PRKAG1, MAPK3, PIK3R2, CALM3, EIF4E2, PPP1CA, BAD",0.847711655616944,0.392544976785331,FALSE +"HCC44","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.26305,1.03,0.393,1065,0.699,"IL2, IL6, IL15RA, MAP3K14, TGFB1",0.405607449624573,0.155522824254319,FALSE +"HCC44","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.30773,1.11,0.383,1020,0.593,"OSM, IL24, IL11, CSF3, IL2, IFNE, CSF2, SPRY2, IL12B, IL6, MYC, IL15RA, IL13, IL6ST, SPRY4, IL20RB, SOCS4, CLCF1, SOCS3, IL6R, SPRED1, IL7R, OSMR, IFNA1",0.416801226031377,0.226945306635737,FALSE +"HCC44","Input","KEGG_LEISHMANIA_INFECTION",0.39455,1.42,0.082,1864,0.343,"NCF2, ITGB2, PTGS2, TNF, C3, IL12B, TGFB2, IL1B, IL1A, FOS, TLR2, CYBA, TGFB1, NFKB1, IFNGR1, NFKBIA, JUN, ITGB1",1.08618614761628,0.464705879957229,FALSE +"HCC44","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.18632,0.784,0.741,1058,0.868,"ITK, NCF2, ITGB2, ICAM1, ARHGAP5, MYL12A, CLDN1, RAC2, CYBA, VCL",0.130181792020672,0.0614802748235081,FALSE +"HCC44","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.59875,-1.76,0.00105,15905,0.0993,"HADHA, EHHADH, ALDH9A1, ECHS1, NAA80",2.97881070093006,1.00305075150462,TRUE +"HCC44","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.28516,-0.838,0.74,17652,1,"PLA2G4B, PLA2G6, PLA2G12A",0.130768280269024,0,FALSE +"HCC44","Input","KEGG_LONG_TERM_DEPRESSION",-0.31732,-0.938,0.581,11495,0.963,"GNAI2, GUCY1A2, PLA2G10, MAP2K1, CACNA1A, ARAF, PRKG1, PRKCG, GUCY1A1, RYR1, GNAO1, GUCY1B1, PPP2CB, PLCB4, GNAI3, GNA11, MAPK1, PPP2R1B, GNAZ, PPP2CA, PPP2R1A, KRAS, PLA2G4B, PLA2G6, GNAQ, HRAS, MAPK3, PLA2G12A, PLCB3",0.235823867609669,0.0163737128754655,FALSE +"HCC44","Input","KEGG_LONG_TERM_POTENTIATION",-0.40745,-1.19,0.192,13640,0.491,"CALML6, ATF4, RPS6KA6, PRKACA, RAP1A, CALM1, PLCB4, PPP1CC, RAPGEF3, CAMK4, MAPK1, PPP3CB, PPP3CC, CAMK2D, RPS6KA1, CAMK2G, KRAS, CALM2, CHP1, GNAQ, PRKX, PPP1CB, HRAS, MAPK3, CALM3, PPP1CA, PLCB3",0.71669877129645,0.308918507877032,FALSE +"HCC44","Input","KEGG_LYSINE_DEGRADATION",-0.50729,-1.47,0.04,11803,0.204,"KMT5B, NSD1, SUV39H2, SETDB1, PIPOX, PLOD1, ALDH7A1, SETDB2, OGDH, SETD1A, ACAT2, OGDHL, AASDHPPT, KMT5A, NSD2, HADHA, EHHADH, GCDH, EHMT1, SETD1B, AADAT, KMT5C, ALDH9A1, NSD3, AASDH, ECHS1, EHMT2, SUV39H1, HADH, ACAT1",1.39794000867204,0.690369832574101,TRUE +"HCC44","Input","KEGG_LYSOSOME",-0.38981,-1.14,0.26,13233,0.539,"SLC11A1, CLTB, AP3B2, GNPTG, ENTPD4, ACP2, PLA2G15, MCOLN1, ABCA2, GGA3, HEXB, AP1M1, ATP6V0D1, ATP6V0B, AP1S1, CLN3, GNPTAB, AP4E1, ATP6V0A1, SORT1, CLTC, AP3S1, AP1S2, AP4B1, NPC2, AP3B1, CTSA, GM2A, SCARB2, GAA, CTSH, GGA2, ATP6V1H, ATP6V0C, GLA, GGA1, AP1M2, GALNS, ARSA, SMPD1, LAPTM4A, AP3M2, CLTA, GALC, AP1B1, ASAH1, SLC17A5, AP3M1, SLC11A2, AP4M1, CTSV, AP3S2, ABCB9, NAGA",0.585026652029182,0.268411234813261,FALSE +"HCC44","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.2661,-0.777,0.832,12927,1,"RAC3, CACNA1D, SOS2, CACNA1H, TGFB3, MAPT, PDGFRB, RASGRF2, FGF1, MAP4K1, RRAS, AKT1, ATF4, CACNB4, CACNG8, DUSP9, RASGRP2, HSPA1L, RAPGEF2, MAP2K7, RPS6KA6, PRKACA, MAPK14, RAP1A, FGF13, MAPK10, FAS, RPS6KA4, FGF12, DDIT3, CACNG4, MAP3K13, MAP3K1, FGF11, LAMTOR3, DUSP3, CDC42, PDGFB, MAPK8IP1, MAPK1, MAP3K2, RASA1, FGFR2, MAP3K6, NFATC4, MAPK8IP2, CACNA2D1, PPP3CB, FGFR4, STMN1, PPP3CC, CRKL, HSPB1, DAXX, MAPK9, MAP3K3, RPS6KA1, DUSP14, MAPK7, MAX, ARRB1, ELK1, CASP3, MAP2K6, STK4, MKNK1, PAK1, GRB2, KRAS, RELA, IKBKB, TAOK2, PLA2G4B, CHP1, CDC25B, SOS1, PLA2G6, MAP3K12, MAPK11, MAP2K5, TAOK3, PRKX, MAP3K11, ATF2, STK3, ARRB2, HRAS, TP53, MAPK3, PLA2G12A, PPM1B, TAB1, CACNB3, MAP4K2",0.0798766737092761,0,FALSE +"HCC44","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26932,1.02,0.348,11955,0.686,"BHLHA15, HHEX, PAX4, NEUROD1, NEUROG3, IAPP, PKLR, INS, FOXA3, HNF4G, SLC2A2, HNF4A, HNF1A, PDX1, ONECUT1, HES1, MAFA, MNX1, HNF1B, GCK, FOXA2, NR5A2",0.458420756053419,0.163675884293248,FALSE +"HCC44","Input","KEGG_MELANOGENESIS",-0.3308,-0.98,0.501,11495,0.882,"GNAI2, WNT7A, KIT, WNT6, ADCY5, MAP2K1, FZD8, WNT4, TCF7L2, FZD3, PRKCG, CAMK2B, WNT10A, FZD7, CREBBP, GNAO1, CALML6, WNT10B, PRKACA, CALM1, PLCB4, GNAI3, FZD4, ADCY6, MAPK1, LEF1, DVL3, FZD2, CAMK2D, CREB1, GSK3B, ADCY9, TCF7L1, CAMK2G, KRAS, DVL2, CALM2, CREB3L4, GNAQ, PRKX, CREB3, HRAS, MAPK3, CALM3, PLCB3",0.300162274132754,0.0545314148681803,FALSE +"HCC44","Input","KEGG_MELANOMA",-0.27923,-0.807,0.783,13205,1,"PDGFRB, FGF1, PDGFC, AKT1, PIK3R1, FGF13, PDGFD, FGF12, FGF11, PDGFB, MAPK1, CDK4, PIK3CA, MDM2, KRAS, E2F1, E2F2, HRAS, TP53, MAPK3, PIK3R2, BAD",0.106238237942057,0,FALSE +"HCC44","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.1842,-0.542,0.989,18060,1,"GSTA4, ADH5, MGST3",0.0048037084028206,0,FALSE +"HCC44","Input","KEGG_MISMATCH_REPAIR",-0.59309,-1.73,0.00316,12953,0.1,"MLH1, POLD1, MSH3, RPA3, PCNA, MSH6, EXO1, RFC4, RFC2, RPA2, POLD3, RPA1, RFC5, POLD4, PMS2, LIG1",2.5003129173816,1,TRUE +"HCC44","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.38148,-1.1,0.29,12016,0.616,"MTOR, AKT2, EIF4B, STK11, PIK3R3, PGF, AKT1, ULK3, TSC1, RPS6KA6, PIK3R1, MAPK1, PDPK1, EIF4EBP1, EIF4E, TSC2, RPS6KA1, PIK3CA, RPS6KB1, ULK1, RPS6KB2, STRADA, MLST8, MAPK3, PIK3R2, VEGFB, EIF4E2",0.537602002101044,0.210419287835575,FALSE +"HCC44","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.21614,0.826,0.691,1373,0.846,"SH2D1B, ITGB2, KLRC2, TNF, CSF2, ICAM1, ICAM2, TNFRSF10D, TNFRSF10A, RAET1E, KLRC3, RAC2, IFNA1, ULBP2, ULBP3, IFNGR1, LAT",0.160521952625802,0.0726296369609765,FALSE +"HCC44","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.17276,0.639,0.978,14215,0.94,"GLP2R, PTGER2, SSTR1, P2RY11, ADRA2B, P2RX5, CHRNA9, ADORA2B, GABRE, HTR7, HRH1, NR3C1, BDKRB1, CHRNA10, GHSR, S1PR3, LHB, F2RL1, BDKRB2, PRSS3, HTR2C, TRPV1, PTGER4, GCGR, GLRB, LHCGR, P2RY13, MC1R, GALR2, PLG, LTB4R, ADRB2, CALCR, GIPR, LEPR, P2RY6, AVPR2, GRIN2D, C3AR1, C5AR1, LTB4R2, LPAR2, PTGDR, P2RY14, GLRA1, GRIN1, P2RX1, TAAR2, CHRNA1, TAAR5, NPBWR2, GPR156, HTR1A, CHRNB3, HTR5A, TAAR6, LPAR1, P2RY1, TAAR8, CSH1, SSTR4, GALR1, CHRM2, HTR1D, SSTR3, FSHB, AGTR2, PRLHR, GABRA6, TAAR9, CHRNA2, MAS1, BRS3, HTR4, ADRB3, GH2, ADORA2A, RXFP2, TACR1, THRB, NTSR2, CNR2, GLRA2, F2RL3, OPRM1, GLRA3, DRD3, CHRNA3, GRM1, LEP, ADRA1A, GZMA, GRIK1, MTNR1B, HTR2B, CCKAR, NPY2R, GABRG1, TAAR1, P2RX3, GRM6, MC2R, FSHR, CYSLTR2, HTR1E, CHRND, GABRA1, PRL, FPR1, P2RY10, P2RX2, GH1, NPY4R, HCRTR1, APLNR, TSHB, HCRTR2, GABRA4, GLP1R, GPR50, GABRB2, FPR3, OPRK1, CHRM5, F2, DRD5, RXFP1, MC3R, CCKBR, FPR2, HTR1F, AVPR1A, CRHR2, S1PR4, GRM7, AVPR1B, TACR3, HRH3, ADCYAP1R1, HTR2A, GABRR2, NPY5R, GRM5, NMUR2, ADRA1D, CGA, CHRNB4, CHRNG, CYSLTR1, VIPR2, GRIA1, HTR6, UTS2R, NPFFR1, GABRA5, GRM3, GRIK3, KISS1R, P2RY8, CRHR1, NMUR1, HTR1B, CHRNA4, GRM2, PTGER3, GHRHR, CHRNA6, GABRR1, PRSS1, CHRNB2, MC5R, P2RY4, F2RL2, NPBWR1, ADORA3, MC4R, MCHR2, AGTR1, MCHR1, PRSS2, GABRB1, OXTR, GABRG3, GRIA2, TRHR, SCTR, GRIK5, P2RY2, EDNRA, EDNRB, TSHR, CHRM1, GRID2, DRD1, CTSG, PTGER1, CNR1, GRM4, GRIN3A, GRIA4, OPRD1, GRIA3, GRM8, TSPO, NTSR1, GRPR, GABRA2, GABRP, PTGIR, LPAR4, GRIN2A, GRIN2B, PTH2R, NPFFR2, HRH2, MLNR, MTNR1A, SSTR2, GPR83, SSTR5, ADRA2A, GABRG2, GNRHR, TACR2, PRLR, NPY1R, GRIK4, DRD2, ADRB1, GABRD, P2RX7, GALR3, NMBR, PTGFR, CHRM4, GABBR2, CALCRL, GRIN2C, GRID1, GRIN3B, GABRQ, PTH1R, PTAFR, GABRB3, GHR, F2R, GRIK2, P2RX6, CHRNE, GPR35, PARD3, HRH4, S1PR1, CHRNA5, TBXA2R, ADRA1B, LPAR3, DRD4, CHRM3, VIPR1, GABRA3, ADRA2C, LPAR6, OPRL1",0.00966114521239857,0.0268721464003014,FALSE +"HCC44","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.44127,-1.32,0.102,12681,0.343,"RIPK2, PIK3R3, CAMK2B, SHC3, SOS2, BCL2, RHOA, NGFR, SHC2, CALML6, AKT1, ATF4, MAP2K7, RPS6KA6, MAGED1, PIK3R1, MAPK14, RAP1A, MAPK10, KIDINS220, CALM1, RPS6KA4, YWHAQ, SORT1, MAP3K1, CAMK4, CDC42, ARHGDIB, MAPK1, PDPK1, TP73, NFKBIE, BAX, YWHAH, PLCG2, CRKL, MAPK9, CAMK2D, MAP3K3, RPS6KA1, MAPK7, PIK3CA, SH2B1, YWHAE, GSK3B, PRDM4, GAB1, IRAK4, RAPGEF1, YWHAZ, ARHGDIA, CAMK2G, GRB2, KRAS, RELA, CALM2, IKBKB, SOS1, MAPK11, PLCG1, MAP2K5, YWHAB, HRAS, TP53, CSK, MAPK3, PIK3R2, CALM3, BAD",0.991399828238082,0.464705879957229,FALSE +"HCC44","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.42565,1.52,0.0755,1602,0.366,"CD38, NAMPT, PNP, NT5E, NADK, NNMT, BST1, AOX1",1.12205304837081,0.436518914605589,FALSE +"HCC44","Input","KEGG_NITROGEN_METABOLISM",-0.21551,-0.624,0.948,9246,1,"CA14, CA7, CA3, CA9, GLUD1, GLUD2, GLS2, CA13, AMT, CPS1, GLUL, CA5B",0.0231916626619338,0,FALSE +"HCC44","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.22184,0.85,0.773,1146,0.824,"TNF, CXCL8, CXCL2, CCL5, IL6, IL1B, TNFAIP3, BIRC3, NFKB1",0.111820506081675,0.0840727883028842,FALSE +"HCC44","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.67389,-1.96,0,14399,0.0698,"RAD50, DCLRE1C, MRE11, FEN1, XRCC6, XRCC4, XRCC5, POLL, NHEJ1",Inf,1.15614457737684,TRUE +"HCC44","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.39943,-1.15,0.24,11127,0.529,"RB1, NRAS, EGF, FOXO3, PIK3CB, MAP2K1, AKT2, ARAF, PRKCG, PIK3R3, CASP9, SOS2, RARB, AKT1, RXRA, PIK3R1, MAPK1, PDPK1, CDK4, PLCG2, PIK3CA, STK4, GRB2, RXRB, KRAS, E2F1, E2F2, ERBB2, SOS1, PLCG1, HRAS, TP53, MAPK3, PIK3R2, BAD",0.619788758288394,0.276544327964814,FALSE +"HCC44","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.37977,-1.11,0.277,12365,0.605,"DTX4, DLL3, ADAM17, NOTCH3, DTX1, CREBBP, DLL1, CTBP2, HDAC1, PSENEN, RBPJ, DTX2, MAML2, DVL3, KAT2B, PSEN2, DVL2, APH1A, RFNG, CTBP1, CIR1",0.557520230935551,0.218244625347531,FALSE +"HCC44","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.56433,-1.63,0.0148,13330,0.118,"CDK7, ERCC1, POLD1, ERCC4, POLE, RAD23B, RPA3, PCNA, CETN2, RFC4, RFC2, POLE4, ERCC5, RPA2, CUL4B, XPA, POLD3, RPA1, ERCC6, RFC5, POLD4, GTF2H5, LIG1, XPC, ERCC3, DDB1, RBX1, DDB2",1.82973828460504,0.928117992693875,TRUE +"HCC44","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.29312,-0.862,0.697,11502,1,"TUSC3, MGAT5, ALG6, MGAT5B, MGAT1, MAN1C1, ALG8, ALG1, MGAT3, DPAGT1, B4GALT2, DPM2, B4GALT3, ALG12, MAN1B1, ALG10B, RPN2, MGAT4A, ALG14, ALG10, DPM1, DPM3",0.156767221901991,0,FALSE +"HCC44","Input","KEGG_OLFACTORY_TRANSDUCTION",0.22342,0.857,0.678,9653,0.839,"OR4F16, OR2K2, OR5B21, OR4F3, OR2B6, OR2A7, OR13H1, OR2A42, OR13A1, CNGA3, OR4F17, OR1N1, OR2A12, CNGB1, OR2A1, OR51M1, OR51I2, OR6C6, OR52J3, OR4C16, OR10AD1, OR51I1, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR51E2, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR51B4, OR2AE1, OR5AK2, CLCA1, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, CALML5, OR2V2, OR56A3, OR10H2, OR52B2, OR1B1, OR2L3, OR8D1, OR11H6, PDC, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5M11, OR13G1, PRKACB, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR52D1, OR5P3, OR52N2, OR8S1, OR2AT4, OR9A2, OR51Q1, OR13D1, OR10H1, OR8D2, OR2T33, OR1J2, OR2S2, OR2A5, OR52H1, CALML3, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, OR2T8, ADCY3, OR4D1, OR2C1, OR8G1, OR4F15, OR52B6, OR2A25, OR2D3, OR1Q1, OR8A1, OR2B2, OR1K1, OR2J3, CLCA2, OR10A6, OR2A2, OR8G5, OR11H4, OR10A4, GUCY2D, OR2L2, OR6B2, OR2D2, PRKG2, OR2AG1, OR10A3, OR10A2, OR7D2, OR2A14, OR13J1",0.168770306132937,0.0762380391712997,FALSE +"HCC44","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.53347,-1.55,0.0264,15010,0.153,"AMT, MTR, MTHFS, SHMT1, MTHFR, MTFMT, DHFR",1.57839607313017,0.815308569182401,TRUE +"HCC44","Input","KEGG_OOCYTE_MEIOSIS",-0.53935,-1.59,0.0157,13899,0.142,"MAD2L2, CDC26, ANAPC10, RPS6KA6, PRKACA, CPEB1, PPP2CB, CALM1, YWHAQ, FBXW11, PPP1CC, ADCY6, MAPK1, CDK2, CDC20, PPP2R1B, SMC1A, PPP3CB, YWHAH, PPP3CC, ANAPC5, ANAPC7, CAMK2D, SKP1, RPS6KA1, STAG3, PPP2R5A, YWHAE, ADCY9, PTTG1, FBXO43, PPP2CA, CCNB1, PPP2R1A, YWHAZ, CAMK2G, ANAPC11, SMC3, CDC23, CALM2, SGO1, CDC27, CHP1, PLK1, PRKX, YWHAB, BUB1, CCNB2, MAD2L1, BTRC, PPP1CB, CDK1, PPP2R5B, MAPK3, ESPL1, RBX1, CALM3, PPP1CA, CDC25C, PKMYT1, PPP2R5D",1.80410034759077,0.847711655616944,TRUE +"HCC44","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.26845,0.964,0.483,13985,0.712,"FUCA2, FUCA1, MANBA, GLB1, MAN2B1, NEU1, MAN2B2, NEU4, NEU2, HEXA, AGA, GBA, MAN2C1, NEU3, ENGASE, HEXB",0.316052869248488,0.147520006363144,FALSE +"HCC44","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.63494,-1.85,0.0021,16086,0.0619,"NDUFA9, NDUFS4, COX7B, ATP6V1A, NDUFV2, ATP5PF, ATP6V1H, ATP6V0C, NDUFS5, NDUFA3, ATP6V1B2, ATP5PB, NDUFB9, SDHD, SDHC, COX6B1, COX7A2L, UQCRQ, UQCRFS1, ATP6V1E1, UQCRC2, ATP6V0E1, CYC1, ATP6V1E2, NDUFB7, NDUFB1, UQCR11, ATP5PD, UQCRHL, ATP5F1E, ATP6V1C1, NDUFA8, COX5A, NDUFA4, NDUFA10, NDUFS8, NDUFS2, COX7C, NDUFV1, ATP5MG, NDUFB8, NDUFB4, NDUFC2, ATP5F1C, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, ATP5ME, COX6A1, NDUFA2, ATP6V1F, NDUFS3, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, COX15, UQCRB, COX8A, NDUFB3",2.67778070526608,1.20830935097988,TRUE +"HCC44","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.2893,1.19,0.235,1723,0.513,"GALNT14, GALNT18, GALNT5, GALNT3, GCNT4, ST3GAL1, ST3GAL2, GALNT6",0.628932137728264,0.289882634888184,FALSE +"HCC44","Input","KEGG_P53_SIGNALING_PATHWAY",-0.45955,-1.34,0.0778,13819,0.321,"PPM1D, CHEK2, SHISA5, FAS, BBC3, CDK2, EI24, CCND3, TP73, CDK4, BAX, TSC2, SESN3, SESN1, MDM2, RRM2, CASP3, CCNB1, RCHY1, GTSE1, PIDD1, CHEK1, TP53I3, COP1, RRM2B, CCNB2, CCNG2, TP53, CDK1, DDB2, APAF1",1.10902040301031,0.493494967595128,FALSE +"HCC44","Input","KEGG_PANCREATIC_CANCER",-0.35801,-1.04,0.377,14157,0.731,"PIK3R1, MAPK10, RALGDS, CDC42, MAPK1, BCL2L1, CDK4, MAPK9, BRCA2, PIK3CA, RALBP1, STAT1, KRAS, RELA, E2F1, IKBKB, E2F2, ERBB2, RALB, TP53, MAPK3, PIK3R2, VEGFB, RAD51, BAD",0.423658649794207,0.13608262304214,FALSE +"HCC44","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.26331,-0.77,0.829,15876,1,"PPCS, COASY, PPCDC",0.0814454694497265,0,FALSE +"HCC44","Input","KEGG_PARKINSONS_DISEASE",-0.62627,-1.85,0.00315,16086,0.0619,"NDUFA9, NDUFS4, COX7B, NDUFV2, ATP5PF, VDAC2, NDUFS5, CASP3, SLC25A4, NDUFA3, ATP5PB, NDUFB9, SDHD, SDHC, COX6B1, COX7A2L, UQCRQ, UQCRFS1, UQCRC2, CYC1, SLC25A6, HTRA2, NDUFB7, NDUFB1, UQCR11, UBE2L3, ATP5PD, UQCRHL, ATP5F1E, NDUFA8, COX5A, NDUFA4, NDUFA10, NDUFS8, NDUFS2, COX7C, UBA1, NDUFV1, NDUFB8, VDAC3, NDUFB4, NDUFC2, ATP5F1C, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, COX6A1, NDUFA2, NDUFS3, APAF1, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, UQCRB, COX8A, NDUFB3",2.5016894462104,1.20830935097988,TRUE +"HCC44","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.32696,-0.954,0.539,13176,0.934,"TLR5, RHOA, TLR4, TUBB4A, CTTN, TUBA1A, YWHAQ, ARPC4, TUBB2B, CDC42, TUBB4B, TUBB, TUBA1B, YWHAZ, ARPC5, ARPC2, NCK2, ARPC3",0.268411234813261,0.0296531237699066,FALSE +"HCC44","Input","KEGG_PATHWAYS_IN_CANCER",-0.24669,-0.727,0.898,12842,1,"WNT10A, TFG, CASP9, RAC3, MLH1, FZD7, SOS2, BCL2, TGFB3, SKP2, CBLC, PDGFRB, CREBBP, RHOA, FGF1, PGF, RARB, CSF2RA, AXIN2, AKT1, CKS1B, WNT10B, DAPK2, RXRA, CCDC6, GLI1, CTBP2, MSH3, ITGA2B, PIK3R1, APPL1, HDAC1, PTK2, FGF13, MAPK10, BMP4, FAS, RALGDS, CBL, FGF12, MSH6, TRAF5, FGF11, FZD4, BCR, CDC42, PDGFB, LAMA4, MAPK1, BCL2L1, CDK2, FGFR2, LEF1, CDK4, BAX, DVL3, APC, FN1, DAPK1, PLCG2, CRKL, FZD2, MAPK9, GSTP1, BRCA2, NCOA4, FH, MAX, PIK3CA, RALBP1, GSK3B, AXIN1, MDM2, CASP3, STAT1, STK36, TPM3, TCF7L1, STK4, PIAS3, CDKN1B, ELOC, FADD, GRB2, RXRB, KRAS, BIRC5, DVL2, RELA, E2F1, SMO, IKBKB, PIAS1, E2F2, PML, ERBB2, SOS1, EGLN2, PLCG1, RALB, ARNT, CTBP1, SUFU, HRAS, TP53, MAPK3, PIK3R2, RBX1, VEGFB, ELOB, RAD51, BAD",0.0467236633326956,0,FALSE +"HCC44","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.39454,-1.16,0.22,14856,0.512,"XYLB, RPEL1, RPE, UGP2, DCXR",0.657577319177794,0.290730039024169,FALSE +"HCC44","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.33773,-0.992,0.47,14924,0.853,"GPI, DERA, RPEL1, PRPS2, PFKL, ALDOA, RPE",0.327902142064283,0.069050968832477,FALSE +"HCC44","Input","KEGG_PEROXISOME",-0.56653,-1.66,0.0139,14879,0.114,"FAR2, AGPS, ACAA1, IDH2, SLC25A17, ACSL3, GNPAT, PEX1, DECR2, EHHADH, PEX16, NUDT12, CAT, ABCD4, AMACR, PEX14, PAOX, SOD1, HMGCL, PEX6, CROT, FAR1, IDH1, PMVK, MPV17, PHYH, ACOX1, PEX26, ACSL1, PXMP4, PECR, PEX13, PEX19, ACOT8, PEX11A, PEX2, PEX11B, MVK, PRDX5",1.8569851997459,0.943095148663527,TRUE +"HCC44","Input","KEGG_PHENYLALANINE_METABOLISM",-0.30137,-0.87,0.694,18020,1,"GOT1, NAA80",0.158640529545145,0,FALSE +"HCC44","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.40758,-1.18,0.211,12578,0.491,"CDS1, INPP5D, PRKCG, PIK3R3, PLCD4, PIK3C2A, PIK3C3, IMPA2, CALML6, PIP5K1A, PIK3R1, CALM1, PLCB4, PIP4K2C, INPP5K, ITPKA, PLCG2, DGKZ, INPP4B, PIP4K2B, PI4KB, ITPKB, PIK3CA, PI4KA, INPP5E, DGKQ, CALM2, DGKA, PIKFYVE, INPPL1, INPP4A, PIK3C2B, PLCD1, PLCG1, CDS2, PIK3R2, CALM3, CDIPT, PLCB3, INPP5B",0.675717544702307,0.308918507877032,FALSE +"HCC44","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.4969,-1.46,0.0439,13076,0.204,"BLVRB, UROS, HCCS, EARS2, BLVRA, CPOX, ALAS1, HMBS, HMOX2, MMAB, PPOX, ALAD, COX15",1.35753547975788,0.690369832574101,TRUE +"HCC44","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.28413,-0.824,0.766,13748,1,"SCP2, RXRA, ACADM, SORBS1, NR1H3, CPT1C, PDPK1, ACAA1, ACSL3, EHHADH, UBC, SCD5, RXRB, SLC27A4, CPT1B, ILK, ACOX1, SLC27A1, ACSL1, DBI",0.115771230367396,0,FALSE +"HCC44","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.30544,-0.892,0.649,11696,1,"CYP7B1, CYP46A1, CYP27A1, HSD17B4, SCP2, AMACR",0.187755303199631,0,FALSE +"HCC44","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.20933,-0.609,0.967,8705,1,"CD79A, PTPRC, CD3D, LCK, ZAP70, BTK, IGLL1, CD19, CD8A, RFXAP, BLNK, JAK3, CD4, TNFRSF13C, RAG1, DCLRE1C, ADA, RFXANK, RFX5, UNG",0.0145735259169983,0,FALSE +"HCC44","Input","KEGG_PRION_DISEASES",0.24129,0.946,0.49,1251,0.724,"CCL5, IL6, IL1B, IL1A, HSPA5, HSPA1A, EGR1",0.309803919971486,0.140261433802853,FALSE +"HCC44","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.46708,-1.36,0.082,13899,0.302,"MAD2L2, CDC26, ANAPC10, RPS6KA6, PRKACA, PIK3R1, MAPK14, CPEB1, MAPK10, GNAI3, ADCY6, MAPK1, CDK2, ANAPC5, ANAPC7, MAPK9, RPS6KA1, PIK3CA, ADCY9, CCNB1, KRAS, ANAPC11, FZR1, CDC23, CDC27, CDC25B, MAPK11, PLK1, CCNA2, PRKX, BUB1, CCNB2, MAD2L1, CDK1, MAPK3, PIK3R2, CDC25C, PKMYT1",1.08618614761628,0.519993057042849,FALSE +"HCC44","Input","KEGG_PROPANOATE_METABOLISM",-0.56638,-1.64,0.0179,13553,0.116,"ALDH7A1, ACACB, ACADM, ACAT2, SUCLA2, LDHA, ABAT, HADHA, EHHADH, ALDH9A1, ACSS1, ECHS1, MCEE, ACSS2, SUCLG1, ACAT1, HIBCH",1.74714696902011,0.935542010773082,TRUE +"HCC44","Input","KEGG_PROSTATE_CANCER",-0.3657,-1.07,0.347,12908,0.668,"CASP9, SOS2, BCL2, PDGFRB, CREBBP, PDGFC, AKT1, ATF4, PIK3R1, PDGFD, PDGFB, MAPK1, CDK2, FGFR2, PDPK1, LEF1, GSTP1, PIK3CA, CREB1, GSK3B, MDM2, TCF7L1, CDKN1B, GRB2, KRAS, RELA, E2F1, CREB3L4, IKBKB, E2F2, ERBB2, SOS1, CREB3, HRAS, TP53, MAPK3, PIK3R2, BAD",0.459670525209126,0.175223537524454,FALSE +"HCC44","Input","KEGG_PROTEASOME",-0.4455,-1.29,0.105,11249,0.362,"PSMD7, PSMD2, PSMD3, PSMC5, PSMB7, PSMA5, PSMB1, PSMD6, PSMF1, PSMB10, PSMB2, PSMA1, PSMB5, PSMA2, PSMB4, PSMC2, PSMB3, PSMA4, PSMD1, PSMD4, PSMD13, PSMB6, PSMD14, PSMC3, SEM1",0.978810700930062,0.441291429466834,FALSE +"HCC44","Input","KEGG_PROTEIN_EXPORT",-0.39777,-1.16,0.233,14823,0.512,"SPCS1, SRP68, SEC61A2, SEC11A, SPCS2, SRP9, IMMP1L, SRP14",0.632644078973981,0.290730039024169,FALSE +"HCC44","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.23545,-0.688,0.91,17617,1,"SLC25A10, MDH1",0.0409586076789064,0,FALSE +"HCC44","Input","KEGG_PURINE_METABOLISM",-0.28405,-0.836,0.76,11825,1,"ADCY5, POLR2C, PDE6B, POLR1B, ITPA, NME1, POLR2A, ADCY10, PDE4C, NUDT5, ENTPD2, AK5, PDE1C, ENTPD8, NME5, PDE8B, POLR3B, GUCY1A1, PDE3B, POLR3GL, NT5C, ENTPD4, POLD1, PDE5A, POLA1, POLR2D, POLE, ENTPD6, PRUNE1, GUCY1B1, POLR2H, NT5M, ADCY6, DCK, RRM1, NPR2, POLE4, PRPS2, ADA, GMPR, POLR2I, PDE9A, POLR2E, POLR3K, ADCY9, RRM2, DGUOK, POLR2J, POLD3, AK1, NME6, PKM, GUK1, POLR2F, POLD4, RRM2B, PRIM2, POLR2K, NUDT2, NUDT9, POLR2G, POLR2L, POLA2, PAPSS1, PDE6D",0.119186407719209,0,FALSE +"HCC44","Input","KEGG_PYRIMIDINE_METABOLISM",-0.36115,-1.06,0.362,13319,0.68,"POLR3GL, NT5C, ENTPD4, POLD1, POLA1, POLR2D, POLE, ENTPD6, POLR2H, NT5M, TXNRD2, DCK, RRM1, POLE4, POLR2I, POLR2E, POLR3K, RRM2, POLR2J, POLD3, NME6, POLR2F, POLD4, RRM2B, PRIM2, POLR2K, NUDT2, DUT, CTPS2, POLR2G, UPRT, UCK1, DTYMK, POLR2L, POLA2, TK1",0.441291429466834,0.167491087293764,FALSE +"HCC44","Input","KEGG_PYRUVATE_METABOLISM",-0.45442,-1.32,0.0979,13327,0.343,"HAGHL, ALDH7A1, ACACB, DLAT, ACAT2, LDHA, GLO1, GRHPR, ALDH9A1, ACYP2, ACSS1, PKM, PDHB, ACSS2, MDH1, HAGH, PDHA1, ACAT1",1.00921730819686,0.464705879957229,FALSE +"HCC44","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.29494,-0.862,0.73,13205,1,"PDGFRB, RHOA, FGD3, FGF1, MYLPF, PDGFC, RRAS, IQGAP2, CHRM3, ITGA4, IQGAP1, PIP5K1A, ITGAE, ITGB6, ITGA2B, TIAM2, PIK3R1, MYL5, PTK2, FGF13, PDGFD, ARPC4, FGF12, PPP1CC, FGF11, PAK4, CDC42, PDGFB, MAPK1, PIP4K2C, MYH14, VAV3, FGFR2, PAK6, ITGA7, APC, FGFR4, FN1, CRKL, SSH2, PFN1, PIP4K2B, NCKAP1, ITGB8, PIK3CA, WASF2, IQGAP3, BRK1, SSH3, FGD1, PAK1, ARPC5, KRAS, CYFIP2, LIMK2, CYFIP1, ARPC2, PIKFYVE, SOS1, ABI2, GSN, CFL1, GIT1, PPP1CB, HRAS, CSK, MAPK3, PIK3R2, ARPC3, PPP1CA",0.136677139879544,0,FALSE +"HCC44","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.3692,-1.08,0.312,11925,0.647,"ATG5, GABARAPL2, PIK3R4, PIK3C3, GABARAPL1, ATG12, ULK3, BECN1, ATG4C, ATG4D, ATG3, GABARAP, ULK1, ATG4B",0.505845405981557,0.1890957193313,FALSE +"HCC44","Input","KEGG_RENAL_CELL_CARCINOMA",-0.40483,-1.19,0.19,11880,0.491,"MAP2K1, CUL2, AKT2, ARNT2, ARAF, PTPN11, PIK3R3, SOS2, TGFB3, CREBBP, PGF, AKT1, PIK3R1, RAP1A, FLCN, PAK4, CDC42, PDGFB, MAPK1, PAK6, CRKL, FH, PIK3CA, GAB1, RAPGEF1, PAK1, ELOC, GRB2, KRAS, SOS1, EGLN2, ARNT, HRAS, MAPK3, PIK3R2, RBX1, VEGFB, ELOB",0.721246399047171,0.308918507877032,FALSE +"HCC44","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.24293,-0.71,0.906,7767,1,"CPA3, MME, AGTR1, CMA1, CTSG, ACE2, NLN, LNPEP, THOP1, CTSA",0.0428718023231869,0,FALSE +"HCC44","Input","KEGG_RETINOL_METABOLISM",-0.21094,-0.626,0.954,17948,1,"RETSAT, ADH5, DGAT1",0.0204516252959049,0,FALSE +"HCC44","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.26854,-0.787,0.836,8605,1,"ACP5, ENPP1, ENPP3, ACP4, MTMR2, ACP2, ACP1, PHPT1, MTMR6",0.0777937225609836,0,FALSE +"HCC44","Input","KEGG_RIBOSOME",-0.26248,-0.764,0.868,15502,1,"RPL8, RPL37A, RPLP2, RPL41, RPL38, RPS2, RPL30, RPS27L, RPS4X, RPS26, MRPL13, RPLP1, FAU",0.0614802748235081,0,FALSE +"HCC44","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.20584,-0.606,0.968,14164,1,"PIN1, MAPK14, MAPK10, MAP3K1, NLRX1, SIKE1, TBKBP1, MAPK9, TRADD, TANK, FADD, RELA, MAVS, IKBKB, MAPK11, OTUD5, TKFC",0.0141246426916063,0,FALSE +"HCC44","Input","KEGG_RNA_DEGRADATION",-0.52036,-1.52,0.0279,15192,0.172,"PAPOLG, XRN1, LSM8, CNOT7, DCP2, MTREX, LSM6, CNOT9, ZCCHC7, ENO3, EDC3, C1D, EXOSC3, LSM1, CNOT6, DDX6, LSM2, WDR61, EXOSC4, LSM3, CNOT6L, LSM4, EXOSC1, PARN, CNOT8",1.5543957967264,0.764471553092451,TRUE +"HCC44","Input","KEGG_RNA_POLYMERASE",-0.44571,-1.31,0.118,11507,0.355,"POLR3D, POLR2C, POLR1B, POLR2A, POLR3B, POLR3GL, POLR2D, POLR2H, POLR2I, POLR2E, POLR3K, POLR2J, POLR2F, POLR2K, POLR2G, POLR2L",0.928117992693875,0.449771646944906,FALSE +"HCC44","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.37925,-1.1,0.285,17182,0.616,"HEMK1, SEPHS2, MAT2B, PAPSS1, LCMT1",0.54515513999149,0.210419287835575,FALSE +"HCC44","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.22876,0.875,0.574,1952,0.83,"PTGS2, COL4A6, FHIT, TRAF1, ITGA2, LAMC2, MYC, CDKN2B, LAMB3, E2F3, TRAF3, COL4A2, COL4A1, BIRC3, NFKB1, LAMB1, LAMA5, NFKBIA, IKBKG, LAMA3, ITGAV, ITGB1, ITGA3",0.241088107602027,0.0809219076239261,FALSE +"HCC44","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.40795,-1.2,0.175,13791,0.509,"VTI1B, VAMP2, STX12, STX3, STX2, VAMP4, BNIP1, STX18, STX17, STX6, STX5, SNAP47, STX4, STX10, TSNARE1, SNAP29, STX7, SNAP23",0.756961951313706,0.293282217663241,FALSE +"HCC44","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.27985,-0.827,0.763,13121,1,"NEU3, CERK, PLPP1, SMPD3, ACER2, SGPL1, ACER3, GLA, ARSA, SMPD1, GALC, SMPD4, ASAH1, SPHK2",0.11747546204512,0,FALSE +"HCC44","Input","KEGG_SPLICEOSOME",-0.50857,-1.52,0.0389,13455,0.172,"HNRNPM, SF3A3, SNRNP40, LSM5, LSM7, MAGOH, HSPA1L, PRPF31, PRPF18, U2AF1, DDX23, PHF5A, SMNDC1, AQR, CRNKL1, DHX8, PRPF8, HNRNPK, SNRPB2, PRPF19, HNRNPU, PPIE, SF3B4, SNRPD2, SNRPF, LSM8, SF3B6, SNRNP200, PLRG1, SNRPE, SRSF3, LSM6, SF3A1, RBM17, PRPF38A, SNRPD1, SNRNP27, SF3B1, PRPF40A, WBP11, LSM2, CCDC12, SNRPC, USP39, PPIH, SNRPA, SYF2, SART1, SLU7, SNRPG, SF3B2, LSM3, CWC15, PRPF40B, SRSF9, LSM4, ZMAT2, XAB2, PUF60, PQBP1, PCBP1, CTNNBL1, THOC3, HNRNPA3, SNRPD3",1.41005039867429,0.764471553092451,TRUE +"HCC44","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.21969,-0.646,0.937,8696,1,"PYGB, PYGM, ENPP1, AMY2B, ENPP3, AGL, MGAM, HK3, TREH, UGT2B7, GCK, PGM1, PGM2, HK1, PGM2L1, GPI, UXS1, GAA, GYS1, UGP2, GANC",0.0282604091122217,0,FALSE +"HCC44","Input","KEGG_STEROID_BIOSYNTHESIS",-0.63231,-1.82,0.00209,15389,0.0676,"TM7SF2, EBP, NSDHL, SQLE, LSS, MSMO1, FDFT1, SC5D, HSD17B7",2.67985371388895,1.17005330405836,TRUE +"HCC44","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.19263,0.734,0.811,1142,0.892,"SRD5A2, CYP1B1, HSD11B2, AKR1C3, AKR1C1",0.090979145788844,0.0496351456238769,FALSE +"HCC44","Input","KEGG_SULFUR_METABOLISM",-0.67475,-1.98,0,17252,0.115,"CHST12, BPNT1, SULT1A3, SUOX, PAPSS1",Inf,0.939302159646388,TRUE +"HCC44","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.17888,-0.518,0.994,16160,1,"SSB, TRIM21, SNRPD1, SNRPD3",0.00261361560268669,0,FALSE +"HCC44","Input","KEGG_TASTE_TRANSDUCTION",0.33855,1.2,0.261,1532,0.53,"TAS2R46, TAS2R14, TAS2R43, TAS2R9, TAS1R3, TAS2R4, ITPR3, TAS2R13, TAS2R10, TAS2R5",0.583359492661719,0.275724130399211,FALSE +"HCC44","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.35056,1.37,0.14,12415,0.373,"GGT1, GAD1, GAD2, BAAT, GGT5, GGT7, ADO, GGT6, CDO1, CSAD",0.853871964321762,0.428291168191312,FALSE +"HCC44","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.63339,-1.86,0.00214,13801,0.0851,"HMGCR, GGPS1, ACAT2, PDSS2, MVD, HMGCS1, IDI1, PMVK, ACAT1, MVK",2.66958622665081,1.07007043991541,TRUE +"HCC44","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.26954,-0.781,0.845,12104,1,"ACVR1C, DCN, ID1, THBS2, ZFYVE16, SMAD9, CHRD, TGFB3, RBL2, CREBBP, RHOA, ID4, ACVR2A, RBL1, BMP7, ID2, THBS4, BMPR1A, BMP4, PPP2CB, SMAD6, MAPK1, PPP2R1B, ACVR1, SKP1, ZFYVE9, THBS3, ACVR2B, PPP2CA, SMAD5, RPS6KB1, PPP2R1A, BMPR2, RPS6KB2, MAPK3, RBX1, SP1",0.0731432910503077,0,FALSE +"HCC44","Input","KEGG_THYROID_CANCER",-0.42694,-1.24,0.133,13926,0.42,"RXRA, CCDC6, MAPK1, LEF1, NCOA4, TPM3, TCF7L1, RXRB, KRAS, HRAS, TP53, MAPK3",0.876148359032914,0.3767507096021,FALSE +"HCC44","Input","KEGG_TIGHT_JUNCTION",-0.30876,-0.911,0.625,11065,0.981,"MYL9, NRAS, ACTN2, CLDN9, MAGI2, PRKCI, CRB3, PATJ, GNAI2, MAP3K20, IGSF5, JAM2, PRKCD, AKT2, CSNK2A1, PRKCG, PARD3, CLDN22, EPB41L3, RHOA, PPP2R2B, EPB41, MYLPF, TJP3, RRAS, PRKCQ, CTTN, AKT1, MYH11, CLDN3, JAM3, MYL5, PPP2CB, LLGL1, PARD6G, SPTAN1, GNAI3, PRKCZ, PPP2R2D, CDC42, MYH14, CASK, PPP2R1B, CDK4, MAGI3, LLGL2, TJAP1, PARD6B, PARD6A, PPP2CA, PPP2R2A, CGN, PPP2R1A, KRAS, MPDZ, EPB41L1, SRC, HRAS",0.204119982655925,0.0083309926200515,FALSE +"HCC44","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.18443,-0.544,0.989,13969,1,"SPP1, MAP2K7, PIK3R1, MAPK14, MAPK10, MAPK1, TICAM1, IRF5, MAPK9, IFNAR1, TLR3, PIK3CA, STAT1, MAP2K6, IRAK4, FADD, RELA, IKBKB, MAPK11, TOLLIP, MAPK3, PIK3R2, TAB1",0.0048037084028206,0,FALSE +"HCC44","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.30515,-0.893,0.654,14333,1,"OGDH, ACAT2, OGDHL, HADHA, EHHADH, GCDH, CAT, AADAT, ALDH9A1, ECHS1, HADH, ACAT1",0.184422251675733,0,FALSE +"HCC44","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.2847,-0.836,0.736,9549,1,"PIK3R5, PIK3CD, HK3, CACNA1B, PDX1, MAPK8, CACNA1C, MAFA, PIK3CB, CACNA1G, SLC2A4, GCK, MTOR, PRKCD, CACNA1A, PIK3R3, HK1, CACNA1D, INSR, KCNJ11, PIK3R1, MAPK10, PRKCZ, MAPK1, MAPK9, PIK3CA, PKM, IKBKB, MAPK3, PIK3R2",0.133122185662501,0,FALSE +"HCC44","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.59358,2.32,0,1735,0.0336,"TNF, IL2, IL12B, IL1B, IL1A, GAD1, CPE, ICA1",Inf,1.47366072261016,TRUE +"HCC44","Input","KEGG_TYROSINE_METABOLISM",-0.32666,-0.959,0.52,17182,0.929,"HEMK1, GOT1, NAA80, ADH5, LCMT1",0.283996656365201,0.0319842860063582,FALSE +"HCC44","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.26296,-0.773,0.843,13042,1,"SOS2, CBLC, RHOA, PRKCQ, AKT1, NFATC3, MAP2K7, PIK3R1, MAPK14, CBL, PAK4, CDC42, MAPK1, VAV3, PDPK1, PAK6, NFATC4, CDK4, NFKBIE, PPP3CB, PPP3CC, MAPK9, PIK3CA, GSK3B, PAK1, GRB2, KRAS, RELA, IKBKB, CHP1, SOS1, NCK2, MAPK11, PLCG1, HRAS, MAPK3, PIK3R2",0.0741724253752577,0,FALSE +"HCC44","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.49681,-1.46,0.0541,13127,0.204,"ITCH, SKP2, CBLC, UBE2B, ANAPC1, UBE2D3, PRKN, FANCL, TRIP12, UBE2Q2, CDC26, ANAPC10, UBE2D2, UBE2N, UBE2Q1, KLHL9, CBL, FBXW11, PRPF19, WWP1, MAP3K1, UBE2Z, MID1, UBE2K, CDC20, SAE1, ANAPC5, UBE2G1, RNF7, ANAPC7, UBE2D1, SKP1, KLHL13, UBE2F, HUWE1, CUL4B, UBE2W, UBA6, HERC3, MDM2, FBXO4, UBR5, PIAS3, CDC34, UBE4B, ELOC, CUL3, ANAPC11, MGRN1, HERC2, FZR1, RCHY1, CDC23, RHOBTB2, UBA3, BRCA1, UBE3B, PIAS1, PPIL2, CDC27, PML, COP1, UBE2L3, STUB1, UBOX5, UBE2I, DDB1, UBE2R2, UBA1, BTRC, CUL7, UBE2C, HERC1, RBX1, ELOB, DDB2",1.26680273489343,0.690369832574101,FALSE +"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.59423,-1.74,0.00624,17102,0.104,"PDHB, IARS2, PDHA1",2.20481541031758,0.98296666070122,TRUE +"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.5125,-1.51,0.0375,12913,0.177,"IVD, BCKDHB, ALDH7A1, DBT, ACADM, ACAT2, ACAA1, ABAT, HADHA, EHHADH, HMGCL, ALDH9A1, HMGCS1, AUH, ECHS1, ACADS, MCEE, ACADSB, HADHB, HSD17B10, HADH, ACAT1, HIBCH",1.42596873227228,0.752026733638193,TRUE +"HCC44","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.31717,-0.939,0.571,11672,0.971,"GUCY1A2, ACTG2, PLA2G10, ADCY5, MAP2K1, PRKCD, ARAF, ARHGEF12, PRKG1, PRKCG, GUCY1A1, CACNA1D, RHOA, RAMP2, PRKCQ, CALML6, ADRA1B, MYH11, KCNMA1, KCNMB4, PRKACA, MYL6B, GUCY1B1, CALM1, PLCB4, PPP1CC, GNA11, KCNMB3, ADCY6, MAPK1, NPR2, ACTA2, ARHGEF11, ADCY9, PPP1R12B, MYL6, CALM2, PLA2G4B, PLA2G6, GNAQ, PRKX, PPP1CB, MAPK3, CALM3, PLA2G12A, PPP1CA, PLCB3",0.243363891754152,0.0127807700919951,FALSE +"HCC44","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.55176,-1.61,0.0158,13038,0.129,"DCTN4, DCTN6, RAB5A, VAMP2, DYNLL2, PRKACA, DYNC1I1, ADCY6, ARHGDIB, RAB5C, CREB1, ADCY9, RAB11B, DCTN5, ARHGDIA, STX4, CREB3L4, DYNLL1, DCTN2, DYNC2LI1, PRKX, CREB3, DCTN1, DYNC1I2, RAB5B, RAB11A",1.80134291304558,0.889410289700751,TRUE +"HCC44","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.32871,-0.96,0.54,13572,0.937,"SHC2, AKT1, NFATC3, PIK3R1, MAPK14, PTK2, NOS3, CDC42, MAPK1, NFATC4, PPP3CB, PPP3CC, PLCG2, HSPB1, PIK3CA, KRAS, PLA2G4B, CHP1, PLA2G6, MAPK11, SRC, PLCG1, SPHK2, HRAS, MAPK3, PIK3R2, PLA2G12A, BAD",0.267606240177031,0.0282604091122217,FALSE +"HCC44","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.47245,-1.38,0.0673,14098,0.277,"PRKACA, ATP6V0D1, ARF1, ATP6V0B, ATP6V1G1, ATP6V0A1, ATP6V1G2, ATP6V1B1, ATP6V0E2, PLCG2, ATP6V1A, ATP6V1H, ATP6V0C, ADCY9, SEC61A2, ATP6V1B2, ATP6V1E1, ATP6V0E1, ATP6V1E2, PLCG1, ATP6V1C1, PRKX, ATP6V1F",1.17198493577602,0.557520230935551,FALSE +"HCC44","Input","KEGG_VIRAL_MYOCARDITIS",0.24298,0.899,0.549,2365,0.807,"ITGB2, ICAM1, RAC2, CD55, ABL2, EIF4G1, CD40, EIF4G3, MYH9, CYCS",0.260427655549908,0.0931264652779296,FALSE +"HCC44","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.32111,-0.937,0.589,10108,0.956,"PPP3R2, PPP3CA, DAAM1, WNT11, WNT2B, PRKCA, CAMK2A, LRP5, PPARD, NKD1, MAPK8, ROCK1, PLCB2, PRICKLE2, FZD5, WNT9A, APC2, CSNK1A1, SIAH1, PPP2R5C, LRP6, WNT7A, CXXC4, WNT6, PPP2R5E, FZD8, WNT4, VANGL2, TCF7L2, CCND2, FZD3, CSNK2A1, FRAT2, DAAM2, PRKCG, CAMK2B, WNT10A, RAC3, FZD7, CREBBP, RHOA, SFRP1, AXIN2, WNT10B, NFATC3, CTBP2, PRKACA, MAPK10, PPP2CB, PLCB4, FBXW11, FZD4, CCND3, LEF1, PPP2R1B, TBL1XR1, NFATC4, DVL3, PPP3CB, APC, PPP3CC, FZD2, MAPK9, CAMK2D, SKP1, PPP2R5A, FRAT1, GSK3B, AXIN1, PPP2CA, TCF7L1, PPP2R1A, CAMK2G, DVL2, CACYBP, CHP1, PRKX, CTNNBIP1, BTRC, CTBP1, TP53, PPP2R5B, RBX1, PLCB3, PPP2R5D",0.229884705212898,0.0195421077238999,FALSE +"A549","Input","KEGG_ABC_TRANSPORTERS",0.2741,0.973,0.471,1809,0.662,"ABCG2, ABCC2, ABCC1, ABCC4, ABCC3, ABCD3, ABCB10",0.326979092871104,0.1791420105603,FALSE +"A549","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.36552,-1.3,0.142,16954,0.76,"BRAF, LEF1, PIK3CA, AKT1, RUNX1, PIK3R3, MAPK3, MTOR, PPARD, PML, PIK3R2",0.847711655616944,0.119186407719209,FALSE +"A549","Input","KEGG_ADHERENS_JUNCTION",0.2964,1.08,0.307,2211,0.546,"PARD3, ACP1, SRC, TGFBR1, TJP1, PTPRJ, IGF1R, ACTG1, ACTN4, PTPRM, VCL, SMAD3, RHOA, SNAI1, SMAD2, NECTIN3, MET, CSNK2A1, FGFR1",0.512861624522813,0.262807357295263,FALSE +"A549","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.20579,0.731,0.83,3746,0.899,"PRKCQ, TRAF2, TNFRSF1A, STAT3, AKT2, CHUK, ACSL3, NFKBIB, ADIPOR2, AKT3, PTPN11, PRKAA2, CAMKK1, CPT1C, ACACB, MAPK9, MAPK8",0.0809219076239261,0.0462403082667712,FALSE +"A549","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.30172,-1.09,0.321,16316,0.654,"GLS2, ABAT, GLUL, GPT, ASS1, IL4I1, ASL, GAD1, GPT2",0.493494967595128,0.184422251675733,FALSE +"A549","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.27822,-0.997,0.413,15843,0.707,"NR3C2, PIK3R1, INSR, PIK3CA, ATP1A1, PIK3R3, MAPK3, PIK3R2",0.384049948343599,0.150580586203101,FALSE +"A549","Input","KEGG_ALLOGRAFT_REJECTION",0.58561,2.1,0.00445,6,0.0918,"IL5",2.35163998901907,1.03715731879876,TRUE +"A549","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.31057,-1.12,0.261,17771,0.725,"PLA2G12A, PLA2G6, PLA2G4B",0.583359492661719,0.139661993429006,FALSE +"A549","Input","KEGG_ALZHEIMERS_DISEASE",0.19008,0.689,0.9,2930,0.925,"GRIN2B, ATP2A2, UQCRFS1, CALM2, TNFRSF1A, PSENEN, COX6B1, IDE, PLCB4, CHP1, NAE1, ATP5F1B, ATP5MC1, PPP3R1, CAPN2, NDUFB10, ADAM17, ATP5F1C, CASP8, GRIN2D, PSEN2, PPP3CA, APAF1, PSEN1, NDUFA9, ADAM10, ATP5MC3, GAPDH, FAS",0.0457574905606751,0.0338582672609674,FALSE +"A549","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.40949,1.49,0.0641,1993,0.326,"EARS2, MTFMT, IARS2, YARS2, FARSB, DARS2, NARS2, SARS2",1.19314197048118,0.486782399932061,FALSE +"A549","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.30292,-1.09,0.301,15267,0.654,"GMPPB, GNPDA1, RENBP, PMM1, GALE, GMPPA, CYB5R1, GALT, UAP1, PGM2, NPL, CYB5R3, GMDS, AMDHD2, HK2",0.521433504406157,0.184422251675733,FALSE +"A549","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.31316,1.13,0.273,3073,0.541,"GRIN2B, TNFRSF1A, TOMM40, CHP1, PPP3R1, MAP2K6, GRIN2D, PPP3CA, APAF1, DERL1, BCL2L1, CYCS",0.563837352959244,0.266802734893431,FALSE +"A549","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.22718,0.814,0.719,1332,0.813,"IFNA13, HSPA2, PSME3, CTSL, HSPA4, HSP90AA1",0.143271109617117,0.0899094544059319,FALSE +"A549","Input","KEGG_APOPTOSIS",0.34892,1.28,0.157,3073,0.439,"MAP3K14, TRAF2, TNFRSF1A, AIFM1, CFLAR, IL1R1, AKT2, TNFRSF10D, CHP1, BIRC3, PRKX, PPP3R1, TNFRSF10A, CHUK, TNFRSF10B, CAPN2, IRAK2, CASP8, AKT3, PPP3CA, APAF1, EXOG, FAS, BCL2L1, TNFRSF10C, CYCS",0.804100347590766,0.357535479757879,FALSE +"A549","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.26509,0.949,0.472,885,0.668,"AKR1C3, GPX2, GGT1, CYP4F3, LTA4H, PLA2G4A",0.326058001365912,0.175223537524454,FALSE +"A549","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.29593,1.1,0.281,793,0.538,"P4HA3, AGMAT, ALDH3A2, AMD1, GLS, ALDH1B1, GOT2",0.55129368009492,0.269217724333611,FALSE +"A549","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.36983,1.33,0.131,1975,0.442,"ATP2A2, SGCD, CACNG7, ITGAV, CACNA2D1, CACNG6, ITGB1, ITGA11, GJA1, ACTG1, ACTN4, ITGB5, SGCA, CDH2, CACNG8",0.882728704344236,0.354577730650908,FALSE +"A549","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.63856,2.32,0,739,0.0861,"UGDH, ALDH3A2, ALDH1B1",Inf,1.06499684854635,TRUE +"A549","Input","KEGG_ASTHMA",0.61896,2.25,0,6,0.0625,"IL5",Inf,1.20411998265592,TRUE +"A549","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.56491,2.05,0.00228,29,0.0873,"IL5, IFNA13",2.64206515299955,1.05898575629443,TRUE +"A549","Input","KEGG_AXON_GUIDANCE",-0.34891,-1.27,0.156,14908,0.796,"RAC3, EPHB1, UNC5A, NFATC1, CXCR4, PLXNC1, NTNG1, SEMA6D, SEMA3F, ABLIM2, EFNB3, SRGAP3, SEMA3D, SEMA6C, EPHB6, EPHA4, EFNA4, PLXNB2, SEMA6A, ARHGEF12, NTN1, EFNA3, SEMA5A, SEMA7A, SLIT2, NCK2, PLXNA2, EFNB1, SEMA3B, UNC5B, LIMK1, SEMA4A, ROBO3, PLXNB3, PAK6, EPHA1, PAK2, PLXNA1, EPHB3, MAPK3, NFATC4, SEMA4C, RAC2, PLXNB1, EFNB2, FYN, SRGAP2, LIMK2, GNAI2, PLXNA3",0.806875401645538,0.0990869322623309,FALSE +"A549","Input","KEGG_BASAL_CELL_CARCINOMA",-0.31089,-1.12,0.284,15378,0.725,"AXIN2, FZD7, AXIN1, DVL2, WNT10A, DVL1, PTCH1, WNT2B, SUFU, STK36, BMP2, LEF1, WNT5A, FZD4, FZD1, GLI3, DVL3",0.546681659952962,0.139661993429006,FALSE +"A549","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.39787,-1.45,0.072,16587,0.797,"STON1, TAF1, TAF13, GTF2B, TAF4, GTF2H2, TAF11, TAF12, TAF6L, GTF2H4, GTF2IRD1",1.14266750356873,0.0985416786038876,FALSE +"A549","Input","KEGG_BASE_EXCISION_REPAIR",0.34063,1.24,0.167,3558,0.457,"NEIL3, TDG, UNG, PCNA, POLE4, LIG3, POLE2, APEX2, POLD4, NEIL2, POLE3, APEX1",0.777283528852417,0.34008379993015,FALSE +"A549","Input","KEGG_BETA_ALANINE_METABOLISM",0.3133,1.14,0.262,3467,0.534,"ALDH3A2, ALDH1B1, HADHA, HIBCH, ALDH2, ECHS1",0.581698708680255,0.272458742971444,FALSE +"A549","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.64676,2.36,0.00217,2949,0.135,"BAAT, ELOVL2, HACD2, HACD1, FADS2, ACOT1, PECR, HADHA, ACOT2, FADS1, YOD1, HSD17B12",2.66354026615147,0.869666231504994,TRUE +"A549","Input","KEGG_BLADDER_CANCER",-0.31765,-1.15,0.238,16340,0.783,"RPS6KA5, MMP1, E2F2, BRAF, RASSF1, MAPK3, CDKN2A, VEGFA, VEGFB",0.623423042943488,0.106238237942057,FALSE +"A549","Input","KEGG_BUTANOATE_METABOLISM",0.24206,0.881,0.588,2903,0.716,"AKR1B10, ALDH3A2, ALDH1B1, HADHA, ACSM3, ALDH2, HMGCS1",0.230622673923862,0.145086977692144,FALSE +"A549","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.26891,-0.951,0.466,14885,0.74,"BLNK, RAC3, VAV2, CD72, NFATC1, JUN, CD22, DAPP1, PIK3R1, BCL10, SYK, PIK3CA, AKT1, PIK3R3, MAPK3, IFITM1, NFATC4, RAC2, FOS, PIK3R2",0.33161408331,0.130768280269024,FALSE +"A549","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2841,1.04,0.374,3051,0.56,"CD38, ATP2A2, CACNA1G, BST1, PHKA1, PLCE1, VDAC1, CALM2, VDAC2, ATP2B1, VDAC3, ADRA1B, GNAL, PLCB4, CHP1, TRPC1, PDE1A, PDE1C, PRKX, PPP3R1, CACNA1H, AGTR1, PLCD3, HRH2, P2RX5, PRKCA, PPID, OXTR, PHKB, GRIN2D, PPP3CA, CAMK2D, HTR2B, SLC25A5, RYR1, ADRA1D",0.42712839779952,0.2518119729938,FALSE +"A549","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.28927,1.07,0.315,1190,0.548,"ATP2A2, UQCRFS1, CACNG7, FXYD2, CACNA2D1, CACNG6, COX6B1, TPM1, TPM2, ATP1B1",0.501689446210399,0.261219441515631,FALSE +"A549","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.2094,0.755,0.82,2687,0.893,"CNTN1, NRCAM, ITGAV, ESAM, ITGAM, CDH4, ITGB1, PVR, PTPRM, CDH2, MPZL1, NEO1, NECTIN3, CLDN1, CLDN2, CADM1, CLDN23, SDC1",0.0861861476162833,0.0491485411114536,FALSE +"A549","Input","KEGG_CELL_CYCLE",0.24874,0.883,0.578,3925,0.72,"YWHAQ, CCND3, ORC4, ORC2, TGFB2, CDC27, ORC5, SMAD3, PCNA, ANAPC5, SMC3, CUL1, MCM6, SMAD2, RBL1, CCNE1, CCNB1, CCNB3, SFN, YWHAG, CDKN1A, CCNB2, SKP1, CDC23, CDC6, PRKDC, CDC26, ORC1, BUB1, PLK1, ANAPC7, SMAD4, STAG2, ANAPC1, CDK1, YWHAB, CDK7, GADD45B, ANAPC11, E2F5, SMC1A, YWHAZ, TTK",0.238072161579471,0.142667503568732,FALSE +"A549","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.18309,-0.678,0.935,14653,0.933,"ADCY4, GNGT1, XCL1, GNB1, VAV2, JAK3, GRK7, BCAR1, CCL5, CXCR4, PRKCD, GNG13, PLCB2, SHC4, PLCB1, SHC3, GNB2, CCL27, GNG7, GNB3, CX3CL1, PIK3R1, RAP1A, PLCB3, SHC2, CCR10, CCL28, BRAF, PIK3CA, AKT1, PRKACA, CRKL, PIK3R3, TIAM2, MAPK3, GRK6, RAC2, GRK4, TIAM1, GRK2, STAT2, GNAI2, FOXO3, PIK3R2",0.0291883891274822,0.0301183562535,FALSE +"A549","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.33335,-1.21,0.181,15325,0.833,"SHC4, GAB2, SHC3, CBLC, CBL, PIK3R1, HDAC1, SHC2, E2F2, TGFB3, BRAF, PIK3CA, AKT1, CDKN1B, CRKL, RUNX1, PIK3R3, MAPK3, CDKN2A, MECOM, CTBP1, BCR, PIK3R2",0.742321425130815,0.0793549985932124,FALSE +"A549","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.54545,-1.94,0.00726,15631,0.372,"CLOCK, CSNK1D, PER1, BHLHE41, CRY2, PER3, NR1D1, CSNK1E",2.13906337929991,0.429457060118102,FALSE +"A549","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29894,1.08,0.279,4429,0.546,"ACLY, IDH3A, DLD, PC, SUCLG1, MDH1, IDH1, IDH3B, SUCLA2, SDHC, ACO1, CS",0.554395796726402,0.262807357295263,FALSE +"A549","Input","KEGG_COLORECTAL_CANCER",-0.26368,-0.951,0.469,14908,0.74,"RAC3, MAPK10, JUN, AXIN2, AXIN1, PIK3R1, BCL2, TGFB3, BRAF, LEF1, PIK3CA, AKT1, PIK3R3, MAPK3, RAC2, RALGDS, FOS, PIK3R2",0.328827157284917,0.130768280269024,FALSE +"A549","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.46565,1.66,0.0226,2571,0.256,"FGA, C5, FGB, FGG, PLG, F2, SERPINE1, PROC, C1S, C4BPA, C4BPB, THBD, F13B, CD59, C5AR1, CFH",1.6458915608526,0.59176003468815,FALSE +"A549","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.30639,1.11,0.283,2736,0.559,"AMD1, GOT2, LDHA, TRDMT1, LDHB, DNMT3B, ADI1, MAT2A, SDS",0.54821356447571,0.252588192113577,FALSE +"A549","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.20573,0.737,0.816,3249,0.908,"IL5, IFNA13, CXCL5, BMPR1B, EDA2R, IL15, TNFRSF1A, TGFBR1, CCL2, CCR7, TGFB2, IL18, CCL26, BMPR1A, IL1R1, TNFRSF10D, IL11, IL13RA1, INHBB, TNFRSF10A, IFNE, CLCF1, TNFRSF10B, PF4, MET, TNFRSF9, FLT4, AMHR2, IL18R1, BMPR2, VEGFD, IL6ST, CSF2RA, TNFSF12, TGFBR2, IFNAR2, TNFSF15, FAS, TNFRSF10C, IL22RA1, TNFSF9, OSMR, EGFR",0.0883098412461389,0.0419141514789149,FALSE +"A549","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.26521,0.949,0.487,2989,0.668,"IFNA13, TBK1, IL18, CHUK, PYCARD, NFKBIB, POLR3K, POLR3G, POLR3F, POLR3D",0.312471038785366,0.175223537524454,FALSE +"A549","Input","KEGG_DILATED_CARDIOMYOPATHY",0.3531,1.29,0.153,1975,0.436,"ATP2A2, SGCD, CACNG7, ITGAV, CACNA2D1, CACNG6, ITGB1, TGFB2, TPM1, ITGA11, TPM2, ACTG1, PRKX, ITGB5, SGCA, TPM4, CACNG8",0.815308569182401,0.360513510731414,FALSE +"A549","Input","KEGG_DNA_REPLICATION",0.43957,1.62,0.0442,4206,0.266,"PRIM1, RNASEH1, RFC5, PCNA, RPA1, POLE4, MCM6, POLE2, POLA1, POLD4, DNA2, RNASEH2B, RFC3, SSBP1, POLE3, FEN1, MCM4",1.35457773065091,0.575118363368933,FALSE +"A549","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.30842,-1.11,0.277,15132,0.682,"SPIRE1, NOTCH2, PIWIL4, NOTCH1, ETV7, NOTCH4, MAPK3",0.557520230935551,0.166215625343521,FALSE +"A549","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.12039,0.435,1,1539,1,"ALDH3A1, MGST1, ALDH3B1",0,0,FALSE +"A549","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.27049,0.992,0.416,2345,0.63,"CES1, UMPS, CDA, UCK2, GMPS, CES5A, HPRT1",0.380906669373257,0.200659450546418,FALSE +"A549","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.20132,0.73,0.867,961,0.892,"VTN, COL4A4, ITGAV, COL5A2, SPP1, ITGB1, COL4A6, ITGA11",0.0619809025237897,0.0496351456238769,FALSE +"A549","Input","KEGG_ENDOCYTOSIS",-0.20255,-0.716,0.866,14554,0.895,"CSF1R, EPS15, KIT, SH3GL3, EHD4, ARFGAP3, IQSEC1, GRK7, CXCR4, CHMP4B, FGFR3, LDLR, ACAP2, ADRB2, EPN3, ARFGAP1, AGAP2, CBLC, PARD6A, CBL, ASAP3, VPS28, RAB11FIP4, RAB11FIP3, HGS, LDLRAP1, RAB5B, AP2A1, FGFR2, SH3GLB2, AP2M1, VPS4A, RAB22A, PSD, RAB11B, ARAP2, VPS37C, ARAP1, GRK6, SH3GL1, VPS37B, MVB12A, SMAP2, GRK4, ACAP3, GRK2, PIP5K1C, DNM2, ARFGAP2",0.0624821079826534,0.048176964684088,FALSE +"A549","Input","KEGG_ENDOMETRIAL_CANCER",-0.34472,-1.25,0.17,15378,0.806,"AXIN2, AXIN1, ELK1, PIK3R1, BRAF, LEF1, PIK3CA, AKT1, PIK3R3, MAPK3, FOXO3, PIK3R2",0.769551078621726,0.0936649581949093,FALSE +"A549","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.23325,0.847,0.644,3746,0.761,"ATP6V1E2, MAP3K14, MAP2K4, SRC, TJP1, CHUK, ATP6V0E1, MET, ADAM17, PTPN11, LYN, ADAM10, EGFR, ATP6V0E2, ATP6V1C1, MAPK9, MAPK8",0.191114132640188,0.118615343229427,FALSE +"A549","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.26041,-0.935,0.516,14851,0.723,"HBEGF, CAMK2B, MAPK10, JUN, RPS6KB2, SHC4, SHC3, CBLC, ELK1, CBL, PIK3R1, SHC2, BRAF, PIK3CA, AKT1, NCK2, GAB1, CDKN1B, CRKL, PAK6, PAK2, PLCG1, PIK3R3, MAPK3, MTOR, MAP2K7, PIK3R2",0.287350298372789,0.140861702705469,FALSE +"A549","Input","KEGG_ETHER_LIPID_METABOLISM",0.25985,0.95,0.49,3570,0.693,"CHPT1, PLA2G4A, PAFAH1B1, PLPP1, PAFAH1B3, AGPS, PLPP2, LPCAT2",0.309803919971486,0.159266765388193,FALSE +"A549","Input","KEGG_FATTY_ACID_METABOLISM",-0.20678,-0.744,0.824,16436,0.897,"ACADVL, ECI1, ACSL5, HADH, GCDH, CPT2",0.0840727883028842,0.0472075569559079,FALSE +"A549","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.25351,-0.908,0.534,14908,0.758,"RAC3, VAV2, MAPK10, PRKCD, GAB2, MAPK12, PIK3R1, SYK, MAPK14, PIK3CA, AKT1, PLA2G12A, LAT, PLCG1, PIK3R3, PLA2G6, MAPK3, PLA2G4B, RAC2, MAPK13, FYN, MAP2K7, PIK3R2",0.272458742971444,0.120330794367946,FALSE +"A549","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.29224,-1.06,0.347,17036,0.624,"MARCKS, PIK3CA, ARPC5L, AKT1, LIMK1, CRKL, LAT, PLCG1, PIK3R3, WASF3, PLA2G6, MAPK3, PLA2G4B, RAC2, PIP5K1C, LIMK2, DNM2, WASF2, PIK3R2",0.459670525209126,0.204815410317576,FALSE +"A549","Input","KEGG_FOCAL_ADHESION",0.23857,0.865,0.566,4730,0.733,"PDGFD, VTN, ROCK2, FLNB, COL4A4, CCND3, ITGAV, COL5A2, SRC, CRK, SPP1, ITGB1, COL4A6, PPP1CC, VAV1, ARHGAP5, ITGA11, AKT2, BIRC3, IGF1R, ACTG1, ACTN4, ITGB5, VCL, CAV1, RHOA, CAPN2, CAV2, RAP1B, PRKCA, HRAS, MET, COL4A1, FLT4, AKT3, COL5A1, ACTB, VEGFD, PPP1R12A, COL4A2, LAMC2, EGFR, COL11A1, PPP1CB, SOS1, PTK2, MAP2K1, ILK, ACTN1, VAV3, FLNA, MAPK9, MAPK8, PXN, ITGB6, LAMC1, DOCK1, ITGA2B, SOS2, FN1, ROCK1, ITGA5, LAMC3, LAMB1, LAMB4, ZYX, VEGFC, LAMA5, ITGA3, PARVA, MYL2, CTNNB1, ARHGAP35, PIK3CB",0.247183568811729,0.134896025358872,FALSE +"A549","Input","KEGG_FOLATE_BIOSYNTHESIS",0.29043,1.07,0.355,179,0.548,"SPR",0.449771646944906,0.261219441515631,FALSE +"A549","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.29031,1.05,0.322,1301,0.551,"AKR1B10, PFKFB3, AKR1B1, PMM2, PFKP",0.492144128304169,0.258848401148215,FALSE +"A549","Input","KEGG_GALACTOSE_METABOLISM",0.29664,1.09,0.299,1897,0.546,"GLA, AKR1B1, B4GALT1, UGP2, PFKP, MGAM, GALK1",0.52432881167557,0.262807357295263,FALSE +"A549","Input","KEGG_GAP_JUNCTION",0.25132,0.929,0.486,4331,0.683,"PDGFD, TUBA4A, SRC, TJP1, PLCB4, GJA1, PRKX, MAP3K2, TUBAL3, PRKCA, HRAS, TUBA1C, TUBA1B, HTR2B, PRKG2, LPAR1, EGFR, SOS1, CDK1, TUBB4A, MAP2K1, TUBB4B, GNAI1, DRD1, TUBB3, KRAS, SOS2, TUBA1A, ADRB1",0.313363730737707,0.165579296318467,FALSE +"A549","Input","KEGG_GLIOMA",-0.28577,-1.02,0.383,15006,0.699,"CAMK2B, SHC4, SHC3, PDGFRB, CALML6, PIK3R1, SHC2, E2F2, BRAF, PIK3CA, AKT1, PLCG1, PIK3R3, MAPK3, CDKN2A, MTOR, PIK3R2",0.416801226031377,0.155522824254319,FALSE +"A549","Input","KEGG_GLUTATHIONE_METABOLISM",0.4543,1.66,0.031,2898,0.256,"PGD, G6PD, GPX2, GSR, GCLM, GCLC, GGT1, MGST1, RRM2B, IDH1, RRM1, MGST2, GPX3",1.50863830616573,0.59176003468815,FALSE +"A549","Input","KEGG_GLYCEROLIPID_METABOLISM",0.34439,1.26,0.153,3410,0.447,"GLA, LCLAT1, DGKG, AKR1B1, ALDH3A2, ALDH1B1, DGKD, GPAT3, AGK, PLPP1, ALDH2, GPAT4, MBOAT2, PLPP2, MGLL",0.815308569182401,0.349692476868064,FALSE +"A549","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.2477,0.906,0.544,2061,0.706,"LCLAT1, CDS2, DGKG, CHPT1, CRLS1, PLA2G4A, DGKD, LPGAT1, GPAT3, GPD1L, ETNK1, GNPAT, PTDSS1, PLPP1",0.26440110030182,0.151195298948196,FALSE +"A549","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.25122,-0.897,0.562,15637,0.769,"SARDH, GNMT, DMGDH, CTH, SHMT2, AMT, GCAT",0.250263684430939,0.114073660198569,FALSE +"A549","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.32423,1.2,0.189,2953,0.461,"ALDH3A1, ENO3, GPI, ALDH3A2, ALDH1B1, LDHA, GALM, PFKP, ALDH3B1, DLD, LDHB, TPI1, PKM, ALDH2, PGAM1, GAPDH, ENO1",0.723538195826756,0.336299074610352,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.30104,-1.07,0.328,15581,0.665,"B3GAT3, CHSY3, CHST14, B3GALT6, CHST12, B4GALT7, UST, CHPF",0.484126156288321,0.177178354696895,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.50018,-1.8,0.0233,12935,0.492,"EXTL1, HS6ST3, EXTL2, HS3ST5, NDST3, HS3ST3B1, EXTL3, B3GAT1, EXT1, HS3ST1, XYLT2, B3GAT3, B3GALT6, HS3ST3A1, HS6ST2, HS6ST1, B4GALT7, NDST2",1.63264407897398,0.30803489723264,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.2953,-1.06,0.346,15219,0.624,"CHST6, B4GAT1, CHST2, B4GALT2, B4GALT3, ST3GAL3",0.460923901207223,0.204815410317576,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.47606,-1.71,0.0197,16275,0.547,"HS3ST3A1, SGSH, HYAL2, IDUA, GUSB",1.70553377383841,0.262012673666569,FALSE +"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.34925,-1.24,0.183,13218,0.79,"ST6GALNAC4, ST8SIA5, ST3GAL1, HEXB, SLC33A1, ST6GALNAC6, ST6GALNAC5, B3GALT4",0.737548910269571,0.102372908709559,FALSE +"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.36646,-1.3,0.159,13444,0.76,"FUT9, ST3GAL1, HEXB, B3GALT5, FUT2, FUT1, B3GALNT1, NAGA",0.798602875679548,0.119186407719209,FALSE +"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.31284,-1.1,0.282,13041,0.667,"FUT7, FUT9, ABO, FUT4, ST3GAL4, B3GALT1, B3GALT5, ST3GAL6, B4GAT1, FUT2, FUT3, FUT1, B4GALT2, B3GNT4, B4GALT3, ST3GAL3",0.549750891680639,0.175874166083451,FALSE +"A549","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.29279,1.05,0.331,4601,0.551,"PIGB, PIGO, PIGF, PIGW, PIGA, PIGN, PIGH, GPLD1, PIGU, PIGC, PIGL, PIGX",0.480172006224281,0.258848401148215,FALSE +"A549","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.30715,1.1,0.276,4623,0.538,"MDH1, MTHFD2, AFMID, MTHFD1, PGP, ACO1, CS, MTHFD2L",0.559090917934782,0.269217724333611,FALSE +"A549","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.27279,-0.984,0.438,14653,0.708,"ADCY4, HBEGF, CACNA1C, CAMK2B, MAPK10, JUN, PRKCD, PLCB2, PLCB1, CALML6, MAPK12, ELK1, GNAS, ITPR3, MAP3K3, PLCB3, MAPK14, LHB, GNA11, PRKACA, MAP3K1, PLA2G12A, ATF4, MAP3K4, PLA2G6, MAPK3, PLA2G4B, MAPK13, MMP14, MAP2K7",0.3585258894959,0.149966742310231,FALSE +"A549","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.2782,-1.01,0.381,8202,0.707,"KIR2DL1, KIR3DL2, IL2, KIR3DL1, KIR2DL3, FASLG, CD80, PRF1, KLRC1, CD86, GZMB, TNF, IL1A, IL6, IL1B",0.419075024324381,0.150580586203101,FALSE +"A549","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.25644,-0.933,0.519,15926,0.715,"CSNK1D, WNT10A, GAS1, BMP7, PTCH1, WNT2B, SUFU, STK36, BMP2, WNT5A, PRKACA, GLI3, CSNK1G2, CSNK1E",0.284832642151542,0.145693958198919,FALSE +"A549","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.25929,0.943,0.498,1152,0.663,"IL5, CD38, ITGAM, IL1R1, IL11",0.302770657240282,0.178486471595227,FALSE +"A549","Input","KEGG_HISTIDINE_METABOLISM",0.4112,1.49,0.0549,2752,0.326,"ALDH3A1, AMDHD1, ALDH3A2, ALDH1B1, ALDH3B1, METTL6, METTL2B, BUD23, ALDH2",1.26042765554991,0.486782399932061,FALSE +"A549","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.33074,1.2,0.219,3298,0.461,"RAD50, RAD51C, NBN, RPA1, RAD54B, BLM, POLD4, RAD51D, SSBP1",0.659555885159882,0.336299074610352,FALSE +"A549","Input","KEGG_HUNTINGTONS_DISEASE",-0.2219,-0.792,0.723,14500,0.856,"TBP, NDUFA1, HDAC2, BBC3, GRIN1, NDUFS8, HTT, DNAH2, ATP5PB, PLCB2, DNALI1, PLCB1, NDUFA2, NDUFV3, UQCRB, NDUFA5, CREB3L1, SDHD, COX8A, COX7C, POLR2J, CREB3L2, UQCR10, SP1, EP300, HDAC1, ATP5PO, PLCB3, PPARGC1A, AP2A1, NDUFA3, DNAH1, NDUFA6, AP2M1, POLR2F, NDUFS6, TAF4, CREBBP, CREB3L4, NDUFC1, UQCRHL, CREB5, NDUFB7, ATP5F1D, UQCR11, NDUFA7, ATP5F1E, NDUFS7, DNAL4, NDUFV1, POLR2H, COX5B",0.140861702705469,0.0675262353228468,FALSE +"A549","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.35307,1.25,0.174,1975,0.452,"ATP2A2, SGCD, CACNG7, ITGAV, CACNA2D1, CACNG6, ITGB1, TGFB2, TPM1, ITGA11, TPM2, ACTG1, ITGB5, SGCA, TPM4, CACNG8",0.7594507517174,0.344861565188618,FALSE +"A549","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.32577,-1.16,0.242,15324,0.787,"PLCB2, PLCB1, INPP5J, PLCB3, ITPKB, PIK3CA, INPP5B, ITPKA, PI4KB, SYNJ1, PLCG1, INPPL1, INPP5E, PI4KA, ALDH6A1, PIP5K1C",0.616184634019569,0.104025267640935,FALSE +"A549","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.26916,-0.95,0.462,15123,0.729,"MAPK10, GYS1, FASN, PYGM, RPS6KB2, SHC4, SHC3, PHKG1, PHKA2, CALML6, CBLC, ELK1, CBL, PIK3R1, MKNK1, PPP1R3D, SHC2, PPARGC1A, INSR, BRAF, PIK3CA, AKT1, FLOT1, TSC1, SORBS1, MKNK2, PRKACA, CRKL, SOCS1, SH2B2, PIK3R3, PTPN1, MAPK3, MTOR, TSC2, PIK3R2, HK2",0.335358024443874,0.137272471682025,FALSE +"A549","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.38221,1.39,0.111,445,0.405,"IL5, MAP3K14, IL15",0.954677021213343,0.392544976785331,FALSE +"A549","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.20203,0.736,0.855,3248,0.9,"IL5, STAT4, IFNA13, CCND3, SOCS5, JAK1, IL15, STAT3, AKT2, IL11, IL13RA1, IFNE, CLCF1, STAT1, AKT3, PTPN11, IL6ST, CSF2RA, PIAS1, IFNAR2, BCL2L1, STAM, SOCS4, STAM2, IL22RA1, OSMR",0.0680338852718274,0.0457574905606751,FALSE +"A549","Input","KEGG_LEISHMANIA_INFECTION",-0.24077,-0.869,0.624,13721,0.806,"TNF, MAPK11, MARCKSL1, TAB2, IL1A, ITGA4, FCGR2A, JUN, IFNGR2, IL1B, MAPK12, ELK1, TLR4, TLR2, MAPK14, ITGB2, TGFB3, MAPK3, MAPK13, TAB1, FOS",0.204815410317576,0.0936649581949093,FALSE +"A549","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.20889,-0.742,0.843,14723,0.888,"ITGA4, SIPA1, JAM2, VAV2, BCAR1, CLDN20, CXCR4, CLDN11, CLDN22, CLDN9, CLDN4, RAPGEF4, MAPK12, MYLPF, PIK3R1, RAP1A, RASSF5, TXK, MAPK14, ITGB2, RAPGEF3, PIK3CA, CLDN7, ICAM1, AFDN, PLCG1, PIK3R3, RAC2, MAPK13, MYL5, GNAI2, PIK3R2",0.0741724253752577,0.051587034221399,FALSE +"A549","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.56669,2.08,0.00654,3467,0.0865,"ALDH3A2, ALDH1B1, HADHA, ALDH2, YOD1, ECHS1",2.18442225167573,1.06298389253519,TRUE +"A549","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.24918,0.912,0.509,885,0.702,"AKR1B10, PLA2G4A",0.293282217663241,0.153662887870195,FALSE +"A549","Input","KEGG_LONG_TERM_DEPRESSION",-0.19783,-0.723,0.851,14941,0.895,"GUCY1B1, PRKG1, PLCB2, PLCB1, GUCY1A1, GNAS, ITPR3, GNAO1, PLCB3, BRAF, GNA11, PLA2G12A, PLA2G6, MAPK3, PLA2G4B, GNAI2",0.0700704399154121,0.048176964684088,FALSE +"A549","Input","KEGG_LONG_TERM_POTENTIATION",0.31951,1.11,0.272,2778,0.559,"GRIN2B, CALM2, RPS6KA3, RPS6KA6, PPP1CC, PLCB4, CHP1, PRKX, PPP3R1, RAP1B, PRKCA, HRAS, GRIN2D, PPP3CA, CAMK2D, PPP1R12A",0.565431095965801,0.252588192113577,FALSE +"A549","Input","KEGG_LYSINE_DEGRADATION",-0.36247,-1.3,0.129,17133,0.76,"KMT5C, OGDHL, KMT5B, SETDB2, PLOD3, OGDH, SETD1B, HADH, DOT1L, AASS, EHMT2, GCDH",0.889410289700751,0.119186407719209,FALSE +"A549","Input","KEGG_LYSOSOME",-0.3232,-1.14,0.235,16365,0.751,"CD164, AP3B2, MANBA, ACP5, ABCB9, TPP1, LAMP3, PPT1, AP4M1, SORT1, MCOLN1, CTSA, NEU1, SGSH, SMPD1, AP3D1, MAN2B1, ATP6V0B, CTSO, ARSG, LAMP1, ATP6V0C, IGF2R, IDUA, AP1B1, PPT2, GUSB, NAGA, GGA1, GNPTG",0.628932137728264,0.124360062995832,FALSE +"A549","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.1989,0.725,0.897,2968,0.882,"CACNA1G, MAP3K14, FLNB, CACNG7, TRAF2, HSPA2, MAP2K4, RPS6KA3, PPM1B, TNFRSF1A, CACNA2D1, CACNG6, TGFBR1, CRK, MAP3K8, TGFB2, FGF2, RPS6KA6, PLA2G4A, IL1R1, ARRB2, AKT2, CHP1, DUSP1, PRKX, BDNF, PPP3R1, CHUK, MAP3K20, CACNA1H, MAP3K2, MAP2K6, NFKB2, RAP1B, CACNG8, PRKCA, TAOK1, HRAS, FGFR1, FGFR4, DUSP5, AKT3, HSPA8, PPP3CA, NF1, PPM1A, GNG12, HSPA1A, TGFBR2, CACNG4, FAS, RASGRP4, RRAS",0.0472075569559079,0.0545314148681803,FALSE +"A549","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.62782,2.24,0.00435,1038,0.0533,"NR5A2, HNF4A, FOXA2, HNF1A, HNF1B, HHEX",2.36151074304536,1.27327279097343,TRUE +"A549","Input","KEGG_MELANOGENESIS",-0.2357,-0.85,0.677,14514,0.822,"WNT6, KIT, ADCY4, CAMK2B, PLCB2, PLCB1, FZD7, CREB3L1, DVL2, CALML6, MC1R, WNT10A, GNAS, CREB3L2, DVL1, EP300, GNAO1, PLCB3, WNT2B, LEF1, WNT5A, FZD4, PRKACA, CREBBP, CREB3L4, FZD1, MAPK3, GNAI2, DVL3",0.169411331314856,0.0851281824599496,FALSE +"A549","Input","KEGG_MELANOMA",-0.23597,-0.83,0.704,15856,0.827,"PDGFRB, FGF22, PDGFC, PIK3R1, FGF12, E2F2, FGF13, BRAF, PIK3CA, AKT1, FGF11, PIK3R3, MAPK3, CDKN2A, PIK3R2",0.152427340857888,0.0824944904474534,FALSE +"A549","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.40668,1.47,0.0775,1756,0.336,"AKR1C2, AKR1C3, ALDH3A1, AKR1C1, MGST1, CYP2S1, ALDH3B1, AKR1C4, EPHX1",1.11069829749369,0.473660722610156,FALSE +"A549","Input","KEGG_MISMATCH_REPAIR",0.62679,2.26,0.00216,3298,0.0807,"MSH6, MLH3, RFC5, PCNA, RPA1, EXO1, MSH2, MSH3, POLD4, MLH1, RFC3, SSBP1",2.66554624884907,1.09312646527793,TRUE +"A549","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.35255,-1.3,0.137,15990,0.76,"MLST8, PIK3R1, STK11, BRAF, PIK3CA, AKT1, TSC1, PIK3R3, MAPK3, MTOR, VEGFA, TSC2, RPS6KA2, VEGFB, PIK3R2",0.863279432843593,0.119186407719209,FALSE +"A549","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.19789,-0.726,0.869,14362,0.903,"KLRK1, ULBP2, ULBP3, RAET1L, RAC3, VAV2, NFATC1, SHC4, SHC3, IFNGR2, ICAM2, PIK3R1, SYK, SHC2, HCST, ITGB2, BRAF, PIK3CA, TNFSF10, ICAM1, IFNAR1, LAT, PLCG1, PIK3R3, MAPK3, NFATC4, RAC2, FYN, SH3BP2, PIK3R2",0.0609802235513335,0.0443122496864942,FALSE +"A549","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.25888,0.946,0.516,427,0.665,"NPY4R, GABRA5, GRIN2B, GLP2R, GABRB3, CHRNA5, HTR1D, PARD3, F2RL2, S1PR3, PLG, P2RY6",0.287350298372789,0.177178354696895,FALSE +"A549","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.29635,-1.06,0.339,15006,0.624,"CAMK2B, MAPK10, RPS6KA1, JUN, PRKCD, SHC4, SHC3, CALML6, MAPK12, NGFR, MAPKAPK2, PIK3R1, RAP1A, RPS6KA5, MAP3K3, ARHGDIB, SHC2, MAPK14, BCL2, CAMK4, SORT1, BRAF, PIK3CA, AKT1, GAB1, CRKL, MAP3K1, ATF4, TP73, PLCG1, SH2B2, PIK3R3, MAPK3, SH2B1, SH2B3, MAPK13, RPS6KA2, MAP2K7, FOXO3, PIK3R2",0.469800301796918,0.204815410317576,FALSE +"A549","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.38506,1.38,0.105,3284,0.405,"CD38, BST1, NAMPT, NT5C2, NNMT, PNP, AOX1, NT5C",0.978810700930062,0.392544976785331,FALSE +"A549","Input","KEGG_NITROGEN_METABOLISM",0.28161,1.06,0.35,3214,0.558,"CA12, CA8, GLS, GLUD2, CPS1, GLUD1",0.455931955649724,0.253365801062421,FALSE +"A549","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.22647,-0.805,0.703,12898,0.867,"MAP3K7, IKBKB, CXCL8, XIAP, MEFV, TRIP6, TNF, MAPK11, PSTPIP1, TAB2, NOD2, TAB3, NLRP3, MAPK10, CCL5, TNFAIP3, IL6, IL1B, MAPK12, CARD9, NLRP1, NAIP, MAPK14, CASP1, MAPK3, MAPK13, TAB1",0.153044674980176,0.0619809025237897,FALSE +"A549","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.38921,1.4,0.0984,2998,0.406,"RAD50, NHEJ1, XRCC5, XRCC4, PRKDC",1.00700490156866,0.391473966422806,FALSE +"A549","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.40776,-1.48,0.0735,16138,0.813,"PIK3R1, RASSF5, E2F2, BRAF, PIK3CA, RASSF1, AKT1, PLCG1, FHIT, PIK3R3, MAPK3, CDKN2A, FOXO3, RXRB, PIK3R2",1.1337126609158,0.0899094544059319,FALSE +"A549","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.39712,-1.41,0.101,16295,0.831,"DVL1, EP300, HDAC1, DLL1, NOTCH1, DTX3L, RBPJ, MAML2, NOTCH4, CREBBP, HES1, MAML1, RFNG, CTBP1, NCSTN, APH1A, DVL3",0.995678626217357,0.080398976215889,FALSE +"A549","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.34276,1.26,0.153,3591,0.447,"DDB2, RFC5, PCNA, CETN2, ERCC8, RPA1, POLE4, ERCC1, ERCC4, POLE2, GTF2H1, POLD4, RFC3, MNAT1, ERCC3, CDK7, POLE3, XPC",0.815308569182401,0.349692476868064,FALSE +"A549","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.26796,-0.946,0.472,12011,0.712,"ALG6, DPM1, ST6GAL1, MGAT5, STT3A, RPN2, ALG14, MAN2A2, DPM3, MGAT4B, MAN1A2, MGAT3, ALG3, ALG11, RPN1, GANAB, ALG12, DPM2, MAN1C1, MAN1B1, MGAT2, DDOST, B4GALT2, MOGS, MAN1A1, B4GALT3, MGAT1",0.326058001365912,0.147520006363144,FALSE +"A549","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.21007,-0.761,0.812,6799,0.89,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, CNGA3, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR5AK2, CLCA1, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, OR4C6, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, OR51E2, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, CAMK2A, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR1B1, OR2L3, OR8D1, OR11H6, PDC, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, CNGA4, OR3A2, OR5P2, OR5B21, OR5M11, OR13G1, OR2L13, OR5K1, OR1M1, OR51B2, OR52D1, OR51I1, OR5P3, OR52N2, OR8S1, OR9A2, OR51Q1, OR13D1, OR8D2, OR2T33, OR2S2, OR2A5, OR52H1, CALML3, OR52A1, OR1C1, OR1F1, OR14I1, OR5C1, OR1J4, OR2B11, CALML5, OR2T8, OR2C1, OR8G1, OR4F15, OR52B6, OR51B4, OR2A25, OR2D3, CAMK2G, OR10H1, OR8A1, OR1K1, OR2J3, OR10A6, OR2A2, OR8G5, OR4F3, OR11H4, OR10A4, GUCY2D, OR13A1, OR2A12, OR2D2, OR2H2, OR2AG1, OR10A3, OR2K2, OR7C1, OR10A2, OR7D2, OR2A14, OR13J1, OR4F16, CLCA2, OR2B6, OR4F17, OR2W3, OR2AG2, OR6A2, OR56B4, OR5K2, OR2A42, OR1L8, OR2AE1, OR10AD1, OR2A1, GUCA1B, OR52W1, OR52I1, CAMK2B, PRKG1, CALML6, OR2L2, OR2A7, PRKACA",0.0904439707588247,0.0506099933550872,FALSE +"A549","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.32718,1.2,0.198,728,0.461,"MTHFS, ATIC, MTFMT",0.703334809738469,0.336299074610352,FALSE +"A549","Input","KEGG_OOCYTE_MEIOSIS",0.3606,1.34,0.12,3914,0.44,"YWHAQ, CALM2, RPS6KA3, RPS6KA6, PPP1CC, CDC27, CHP1, PPP2CB, IGF1R, SGO1, PRKX, PPP3R1, SLK, ANAPC5, SMC3, CUL1, AURKA, CCNE1, CCNB1, PPP3CA, CAMK2D, YWHAG, CCNB2, SKP1, CDC23, CDC26, BUB1, AR, PLK1, ANAPC7, ANAPC1, PPP2R5E, FBXW11, PPP1CB, CDK1, YWHAB, MAP2K1, ANAPC11, FBXO43, SMC1A, YWHAZ, PPP2R1A",0.920818753952375,0.356547323513813,FALSE +"A549","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.55522,-1.99,0.00748,16382,0.59,"MAN2C1, MANBA, MAN2B2, NEU1, MAN2B1, NEU3",2.12609840213554,0.229147988357856,FALSE +"A549","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.26587,-0.946,0.481,15105,0.712,"ATP6V1B1, ATP5PB, LHPP, NDUFA2, NDUFV3, UQCRB, NDUFA5, ATP6AP1, SDHD, COX8A, COX7C, UQCR10, ATP5PO, ATP6V1G2, NDUFA11, NDUFA3, NDUFA6, ATP5MG, NDUFS6, ATP5ME, NDUFC1, ATP6V0B, UQCRHL, ATP6V0C, NDUFB7, ATP5F1D, UQCR11, NDUFA7, ATP5F1E, NDUFS7, NDUFV1, COX5B",0.317854923626168,0.147520006363144,FALSE +"A549","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.4791,1.73,0.0362,3741,0.246,"GCNT3, GALNT13, GALNT10, GALNT14, GALNT1, GALNT18, GALNT4, C1GALT1C1, GALNT16, GALNT2, GALNT7, C1GALT1",1.44129142946683,0.609064892896621,TRUE +"A549","Input","KEGG_P53_SIGNALING_PATHWAY",0.25453,0.9,0.575,3564,0.702,"TP53I3, CCND3, SERPINE1, DDB2, RRM2B, TNFRSF10B, CASP8, CCNE1, CCNB1, CCNB3, APAF1, SFN, CDKN1A, CCNB2, FAS, CYCS, CDK1, IGFBP3, GADD45B, STEAP3",0.24033215531037,0.153662887870195,FALSE +"A549","Input","KEGG_PANCREATIC_CANCER",-0.27333,-0.982,0.449,16063,0.698,"ARHGEF6, PIK3R1, E2F2, RALA, TGFB3, BRAF, PIK3CA, AKT1, PIK3R3, MAPK3, CDKN2A, VEGFA, RAC2, RALGDS, VEGFB, PIK3R2",0.347753658996677,0.156144577376839,FALSE +"A549","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.17439,-0.63,0.979,11352,0.964,"VNN1, DPYS, ENPP3, UPB1, VNN2, PPCS, PANK4",0.00921730819686218,0.0159229660971692,FALSE +"A549","Input","KEGG_PARKINSONS_DISEASE",-0.23122,-0.833,0.656,15433,0.834,"NDUFA2, NDUFV3, UQCRB, NDUFA5, SDHD, COX8A, COX7C, PRKN, UQCR10, SNCA, ATP5PO, NDUFA3, NDUFA6, UBE2J2, UBE2L6, UBE2G2, NDUFS6, NDUFC1, UQCRHL, NDUFB7, ATP5F1D, UQCR11, NDUFA7, ATP5F1E, UBA7, NDUFS7, NDUFV1, COX5B",0.18309616062434,0.0788339493622613,FALSE +"A549","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.38862,1.42,0.0905,2529,0.393,"YWHAQ, ROCK2, TUBA4A, ARPC3, NCL, ITGB1, KRT18, ACTG1, TUBAL3, RHOA, PRKCA, EZR, CLDN1, ARPC4, TUBA1C, TUBA1B, ACTB",1.0433514207948,0.405607449624573,FALSE +"A549","Input","KEGG_PATHWAYS_IN_CANCER",-0.21416,-0.763,0.808,15302,0.899,"LAMA4, IL6, AXIN2, PIAS4, CCNA1, FGFR3, RXRA, FZD7, AXIN1, DVL2, ARNT, RBX1, PDGFRB, CBLC, FGF22, WNT10A, CBL, PIK3R1, LAMA1, SKP2, RASSF5, DVL1, EP300, HDAC1, MMP1, FGF12, PTCH1, WNT2B, PAX8, TRAF4, E2F2, SUFU, STK36, BMP2, FGF13, BCL2, RALA, ELOB, TGFB3, FGFR2, BRAF, LEF1, PIK3CA, RASSF1, AKT1, CCNE2, WNT5A, FGF11, FZD4, CDKN1B, CRKL, CREBBP, CDKN2B, PIAS3, RUNX1, PLCG1, PIK3R3, FZD1, MAPK3, CDKN2A, GLI3, MTOR, FLT3LG, VEGFA, RAC2, RALGDS, MAX, MECOM, CTBP1, VEGFB, FOS, BCR, PPARD, DVL3, PML, RXRB, PIK3R2",0.0925886392254138,0.0462403082667712,FALSE +"A549","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.53474,1.94,0.0143,1276,0.137,"UGDH, AKR1B1, RPE, RPEL1, UGP2",1.84466396253494,0.863279432843593,TRUE +"A549","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.45145,1.64,0.0411,1965,0.259,"PGD, G6PD, TKT, GPI, RPE, RPEL1, RBKS, PFKP, PRPS1, TALDO1",1.38615817812393,0.586700235918748,FALSE +"A549","Input","KEGG_PEROXISOME",-0.27864,-0.985,0.425,15908,0.72,"PAOX, PMVK, PEX3, PEX6, PEX11G, PEX1, PXMP2, PEX11B, PEX19, PEX10, PRDX5, ACSL5, IDH2, FAR2, PEX16, PEX26, ABCD4, PEX7, ACOT8, ABCD1, HMGCL, PEX14",0.371611069949688,0.142667503568732,FALSE +"A549","Input","KEGG_PHENYLALANINE_METABOLISM",0.3522,1.3,0.132,1539,0.446,"ALDH3A1, GOT2, ALDH3B1",0.87942606879415,0.350665141287858,FALSE +"A549","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.3203,-1.18,0.209,15324,0.766,"PLCB2, PLCB1, INPP5J, CALML6, CDS1, PIK3R1, ITPR3, PLCB3, ITPKB, PIK3CA, INPP5B, ITPKA, PI4KB, DGKZ, DGKQ, SYNJ1, PLCG1, INPPL1, PIK3R3, INPP5E, PI4KA, PIP5K1C, PIK3R2",0.679853713888946,0.115771230367396,FALSE +"A549","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.33456,1.23,0.183,2727,0.463,"HMOX1, EARS2, COX15, COX10, BLVRB, HCCS, FECH, FTH1, ALAS1",0.737548910269571,0.334419008982047,FALSE +"A549","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.22384,-0.799,0.749,17311,0.867,"ACSL5, SORBS1, PLTP, SLC27A1, PPARA, PPARD, CPT2, RXRB",0.125518182300534,0.0619809025237897,FALSE +"A549","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45993,1.71,0.0246,3031,0.246,"BAAT, AKR1C4, HSD3B7, SLC27A5, ACOX2",1.60906489289662,0.609064892896621,TRUE +"A549","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.33263,-1.19,0.206,12250,0.811,"CD3D, CD19, IL2RG, IGLL1, LCK, RAG1, BLNK, JAK3, DCLRE1C, CIITA, TAP2, IL7R, TNFRSF13C, RFXAP, RFXANK",0.686132779630847,0.090979145788844,FALSE +"A549","Input","KEGG_PRION_DISEASES",-0.29271,-1.06,0.324,15251,0.624,"CCL5, IL6, IL1B, NCAM2, ELK1, NCAM1, NOTCH1, PRKACA, MAPK3, FYN, EGR1",0.489454989793388,0.204815410317576,FALSE +"A549","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.21174,-0.755,0.796,15123,0.889,"MAPK10, RPS6KA1, CCNA1, ANAPC2, MAPK12, PKMYT1, PIK3R1, MAPK14, BRAF, PIK3CA, AKT1, PRKACA, FZR1, PIK3R3, MAD2L2, MAPK3, MAPK13, RPS6KA2, GNAI2, PIK3R2",0.0990869322623309,0.0510982390297863,FALSE +"A549","Input","KEGG_PROPANOATE_METABOLISM",0.35508,1.29,0.164,3700,0.436,"ALDH3A2, ALDH1B1, LDHA, LDHB, SUCLG1, HADHA, ACACA, HIBCH, ALDH2, ACACB, ECHS1, SUCLA2, ACAT1",0.785156151952302,0.360513510731414,FALSE +"A549","Input","KEGG_PROSTATE_CANCER",-0.2988,-1.07,0.332,15622,0.665,"CREB3L1, PDGFRB, PDGFC, PIK3R1, CREB3L2, EP300, E2F2, BCL2, FGFR2, BRAF, LEF1, PIK3CA, AKT1, CCNE2, CDKN1B, CREBBP, ATF4, CREB3L4, PIK3R3, MAPK3, MTOR, CREB5, PIK3R2",0.478861916295964,0.177178354696895,FALSE +"A549","Input","KEGG_PROTEASOME",0.49313,1.78,0.023,3432,0.219,"PSMA4, PSMC4, PSMB6, PSMD12, PSME3, PSMD8, PSMD1, PSMD11, PSMD14, PSME4, PSMC5, PSMA1, PSMB5, PSMA6, POMP, PSMC6, PSMC1, PSMA3, PSMA2, PSMF1, PSMB3",1.63827216398241,0.659555885159882,TRUE +"A549","Input","KEGG_PROTEIN_EXPORT",0.29925,1.1,0.274,3377,0.538,"SEC11A, OXA1L, SRP68, SEC61A2, SEC62, SEC11C, SRP72",0.562249437179612,0.269217724333611,FALSE +"A549","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.31653,1.14,0.284,3303,0.534,"FXYD2, GLS, ATP1B1, GLUD2, MDH1, GLUD1, ATP1B3",0.546681659952962,0.272458742971444,FALSE +"A549","Input","KEGG_PURINE_METABOLISM",0.36439,1.31,0.146,2835,0.444,"PDE11A, PDE4D, PDE3A, ATIC, PDE10A, PDE8A, NME1, PDE7B, PDE4B, POLR2I, PRIM1, DGUOK, NT5C2, ADA, PDE1A, POLR1E, PDE1C, PRPS1, RRM2B, NME2, PAPSS2, POLE4, POLR2C, GMPS, POLE2, PNP, PKM, NME4, PFAS, HPRT1, POLA1, PNPT1, POLR3K, POLR3G, POLR3F, ADPRM, POLD4, RRM1, PDE6G, PAICS",0.835647144215563,0.35261702988538,FALSE +"A549","Input","KEGG_PYRIMIDINE_METABOLISM",0.38387,1.37,0.113,4771,0.406,"CTPS1, TXNRD1, NME1, UMPS, POLR2I, PRIM1, NT5C2, CDA, POLR1E, RRM2B, NME2, POLE4, POLR2C, UCK2, POLE2, PNP, NME4, POLA1, PNPT1, POLR3K, POLR3G, DTYMK, POLR3F, POLD4, RRM1, CMPK1, POLR3D, NT5C, POLR1B, AK3, POLR2D, UPRT, POLE3, DHODH, TK1, NME7, POLR2L, ITPA, NT5C3A, POLR3H, POLR3C, POLR3B, CTPS2, POLR1D, POLR1A, TXNRD2",0.94692155651658,0.391473966422806,FALSE +"A549","Input","KEGG_PYRUVATE_METABOLISM",0.44128,1.6,0.0474,2894,0.27,"AKR1B1, ME1, ALDH3A2, ALDH1B1, LDHA, DLD, LDHB, PC, ME2, MDH1, PKM, ACACA, ALDH2, ME3",1.32422165832591,0.568636235841013,FALSE +"A549","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.19725,0.728,0.833,4136,0.886,"PDGFD, ROCK2, ITGAV, ITGAM, ARPC3, ITGAE, F2, CRK, ITGB1, FGF2, PPP1CC, GNA13, VAV1, ITGA11, NCKAP1, TMSB4Y, ACTG1, ACTN4, CFL2, ITGB5, VCL, RHOA, CFL1, TMSB4X, HRAS, CYFIP2, EZR, FGFR1, FGFR4, ARPC4, ACTB, RDX, ENAH, PFN1, GNG12, PPP1R12A, RRAS, SSH2, MSN, EGFR, CYFIP1, PPP1CB, SOS1, PTK2, RRAS2, MAP2K1, F2R, ACTN1, VAV3, BRK1, APC, PXN, ITGB6, BDKRB2, DOCK1, ITGA2B, KRAS, PFN4, SOS2, FN1",0.0793549985932124,0.0525662781129492,FALSE +"A549","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.33093,1.22,0.178,3285,0.469,"IFNA13, ULK1, ULK2, PRKAA2, ATG7, ATG4C",0.749579997691106,0.328827157284917,FALSE +"A549","Input","KEGG_RENAL_CELL_CARCINOMA",-0.30778,-1.1,0.283,15797,0.667,"ARNT, RBX1, PIK3R1, RAP1A, EP300, ELOB, TGFB3, BRAF, PIK3CA, AKT1, GAB1, CRKL, CREBBP, PAK6, PAK2, PIK3R3, MAPK3, VEGFA, VEGFB, PIK3R2",0.54821356447571,0.175874166083451,FALSE +"A549","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.23516,0.869,0.616,1808,0.733,"NLN, AGTR1",0.210419287835575,0.134896025358872,FALSE +"A549","Input","KEGG_RETINOL_METABOLISM",0.29618,1.1,0.289,3817,0.538,"ALDH1A1, CYP26A1, BCO1, CYP26B1, DHRS3, DHRS4, CYP2C9, DHRS4L2, RDH11, RDH5, PNPLA4",0.539102157243452,0.269217724333611,FALSE +"A549","Input","KEGG_RIBOFLAVIN_METABOLISM",0.43987,1.58,0.0672,409,0.277,"RFK, ACP1",1.17263072694617,0.557520230935551,FALSE +"A549","Input","KEGG_RIBOSOME",-0.31709,-1.11,0.276,16409,0.682,"RPS23, RPL9, RPL38, RPS21, RPL28, RPS25, RPS8, RPL18A, RPS15, RPS10, RPL3, RPL22, RPS18, RPL13, RPS28, RPS12, RPL35A, RPL37, RPL36, FAU",0.559090917934782,0.166215625343521,FALSE +"A549","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.2012,0.752,0.82,2264,0.89,"IFNA13, TBK1, DDX3Y, TRAF2, DDX3X, CHUK, IFNE, NFKBIB, CASP8",0.0861861476162833,0.0506099933550872,FALSE +"A549","Input","KEGG_RNA_DEGRADATION",0.27831,1.03,0.371,3655,0.571,"PARN, ENO3, HSPD1, XRN2, EXOSC5, PAPOLA, HSPA9, WDR61, LSM5, PNPT1, CNOT7, C1D, PAPOLG, EXOSC1, ENO1, MPHOSPH6, CNOT9, CNOT1, LSM1, EXOSC3",0.430626090384954,0.243363891754152,FALSE +"A549","Input","KEGG_RNA_POLYMERASE",0.32365,1.18,0.229,4747,0.484,"POLR2I, POLR1E, POLR2C, POLR3K, POLR3G, POLR3F, POLR3D, POLR1B, POLR2D, POLR2L, POLR3H, POLR3C, POLR3B, POLR1D, POLR1A",0.640164517660112,0.315154638355588,FALSE +"A549","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.25081,0.9,0.551,4652,0.702,"GGT1, METTL6, PAPSS2, METTL2B, MAT2A, BUD23, SEPHS1, AHCYL1, AHCY, MARS2, MAT2B",0.258848401148215,0.153662887870195,FALSE +"A549","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.23175,0.844,0.65,3074,0.759,"RARB, COL4A4, ITGAV, TRAF2, ITGB1, COL4A6, AKT2, BIRC3, CHUK, CKS1B, COL4A1, CCNE1, AKT3, APAF1, PTGS2, TRAF3, PIAS1, COL4A2, BCL2L1, CYCS, LAMC2",0.187086643357144,0.11975822410452,FALSE +"A549","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.45204,-1.62,0.0289,16460,0.632,"VAMP4, STX10, STX16, STX12, SEC22B, STX5, VAMP5, TSNARE1, VAMP2, STX3, SNAP29, USE1, SNAP23",1.53910215724345,0.199282921717615,FALSE +"A549","Input","KEGG_SPHINGOLIPID_METABOLISM",0.33046,1.21,0.179,3275,0.475,"GLA, GAL3ST1, SGMS1, DEGS1, ASAH2, GALC, PLPP1, ACER3, SPTLC2, SGPP1, SPTLC1, PLPP2",0.747146969020107,0.323306390375133,FALSE +"A549","Input","KEGG_SPLICEOSOME",-0.30687,-1.12,0.266,17451,0.725,"DHX16, PRPF6, SNU13, TRA2B, LSM4, PRPF38B, SRSF4, CCDC12, PPIH, SYF2, SF3A1, HNRNPA1L2, SNRPD1, LSM7, MAGOH, SNRPD3, LSM6, CWC15, SRSF5, NCBP2, DDX39B, CHERP, XAB2, PRPF38A, SF3A2",0.575118363368933,0.139661993429006,FALSE +"A549","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.25014,0.897,0.531,1700,0.699,"UGDH, PGM2L1, GPI, UGP2, MGAM",0.274905478918531,0.155522824254319,FALSE +"A549","Input","KEGG_STEROID_BIOSYNTHESIS",-0.44337,-1.58,0.0479,15767,0.631,"CEL, SC5D, CYP27B1, TM7SF2, DHCR24, LSS",1.31966448658544,0.199970640755866,FALSE +"A549","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.42547,1.54,0.0629,1711,0.292,"AKR1C2, AKR1C3, SULT2B1, AKR1C1, SRD5A2, HSD17B6, AKR1C4",1.20134935455473,0.534617148551582,FALSE +"A549","Input","KEGG_SULFUR_METABOLISM",0.36038,1.31,0.147,2967,0.444,"SULT2B1, CHST11, PAPSS2, SULT1A4",0.832682665251824,0.35261702988538,FALSE +"A549","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.43534,1.56,0.0379,1426,0.283,"GRIN2B, C5, SNRPB, SSB, C1S, ACTN4",1.42136079003193,0.54821356447571,FALSE +"A549","Input","KEGG_TASTE_TRANSDUCTION",0.24979,0.912,0.536,1430,0.702,"TAS2R50, TAS2R9, PDE1A, ASIC2, TAS2R14, PRKX",0.27083521030723,0.153662887870195,FALSE +"A549","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.53176,1.91,0.0128,374,0.142,"BAAT, GGT1",1.89279003035213,0.847711655616944,TRUE +"A549","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.32003,-1.14,0.263,15900,0.751,"DHDDS, PMVK, FDPS, MVD",0.580044251510242,0.124360062995832,FALSE +"A549","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28987,1.05,0.334,3397,0.551,"BMPR1B, ROCK2, TGFBR1, TGFB2, BMPR1A, BMP6, PPP2CB, INHBB, SMAD3, RHOA, CUL1, SMAD2, RBL1, SMAD6, LTBP1, SMAD7, RPS6KB1, AMHR2, ZFYVE16, BMPR2, SKP1, TGFBR2, ID3, SMAD4, ID2",0.476253533188435,0.258848401148215,FALSE +"A549","Input","KEGG_THYROID_CANCER",-0.30502,-1.11,0.27,16623,0.682,"PAX8, BRAF, LEF1, MAPK3, RXRB",0.568636235841013,0.166215625343521,FALSE +"A549","Input","KEGG_TIGHT_JUNCTION",0.20647,0.76,0.787,2568,0.903,"PRKCQ, PARD3, PPP2R2C, SRC, TJP1, AKT2, PPP2CB, ACTG1, ACTN4, PPP2R2A, MAP3K20, RAB3B, RHOA, PRKCA, HRAS, CSNK2A1, MPDZ, CLDN1, CLDN2, AKT3, ACTB, CLDN23",0.104025267640935,0.0443122496864942,FALSE +"A549","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.23446,-0.845,0.644,15123,0.821,"MAPK10, JUN, CCL5, IL6, IL1B, TLR5, MAPK12, TLR4, PIK3R1, TLR2, MAPK14, TIRAP, LY96, PIK3CA, AKT1, TLR3, TOLLIP, IFNAR1, PIK3R3, MAPK3, IRF7, MAPK13, TICAM1, TAB1, FOS, MAP2K7, PIK3R2",0.191114132640188,0.0856568428805592,FALSE +"A549","Input","KEGG_TRYPTOPHAN_METABOLISM",0.25942,0.956,0.48,3700,0.689,"KYNU, ALDH3A2, ALDH1B1, IDO2, HADHA, ALDH2, AFMID, AADAT, TDO2, AOX1, ECHS1, ACAT1",0.318758762624413,0.161780778092374,FALSE +"A549","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.3654,-1.33,0.136,12793,0.929,"MAFA, CACNA1B, PDX1, IKBKB, CACNA1A, GCK, TNF, SLC2A4, HK1, CACNA1C, MAPK10, PRKCD, KCNJ11, PIK3R1, INSR, PIK3CA, SOCS1, PIK3R3, MAPK3, MTOR, PIK3R2, HK2",0.866461091629782,0.0319842860063582,FALSE +"A549","Input","KEGG_TYPE_I_DIABETES_MELLITUS",-0.2424,-0.862,0.609,11839,0.808,"PTPRN2, IL12A, CD86, GZMB, TNF, IL1A, IL1B, CPE, ICA1, GAD1",0.215382707367125,0.0925886392254138,FALSE +"A549","Input","KEGG_TYROSINE_METABOLISM",0.27577,1.02,0.419,1856,0.582,"HGD, ALDH3A1, GOT2, ALDH3B1, METTL6, METTL2B",0.377785977033705,0.235077015350112,FALSE +"A549","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.21793,-0.793,0.763,15885,0.866,"CBLC, MAPK12, CBL, PIK3R1, BCL10, MAPK14, PIK3CA, AKT1, NCK2, PAK6, LAT, PAK2, PLCG1, PIK3R3, MAPK3, NFATC4, DLG1, MAPK13, FYN, FOS, MAP2K7, PIK3R2",0.11747546204512,0.0624821079826534,FALSE +"A549","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.26016,0.949,0.479,3348,0.668,"NEDD4, UBA2, CUL3, UBE2G1, HERC4, UBE2A, BIRC6, CDC27, UBE2Q2, UBE2S, DDB2, BIRC3, MID1, BRCA1, ANAPC5, ERCC8, WWP1, CUL1, FANCL, UBE2D1, SAE1, TRIM32, UBE2E1, CUL2, KLHL9, UBE2N, SKP1, CDC23, PIAS1, UBE2D2, CDC26, TRIM37, UBE2M, ANAPC7, ANAPC1, FBXW11, ELOC",0.319664486585437,0.175223537524454,FALSE +"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.33611,-1.2,0.195,18726,0.821,"VARS2",0.709965388637482,0.0856568428805592,FALSE +"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.38891,-1.39,0.108,18177,0.808,"PCCB, BCKDHB, ACAD8, HADH, MCCC1, ALDH6A1, IVD, OXCT1, HMGCL",0.96657624451305,0.0925886392254138,FALSE +"A549","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.19282,0.683,0.905,2257,0.923,"PPP1R14A, PRKCQ, ROCK2, CALM2, PPP1CC, ADRA1B, GNA13, PLA2G4A, PLCB4, PRKX, RHOA, AGTR1, PRKCA, CALD1",0.0433514207947967,0.0347982989740879,FALSE +"A549","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.27591,-1,0.404,15622,0.714,"CREB3L1, GNAS, CREB3L2, ARHGDIB, RAB5B, DYNC1I1, PRKACA, CREB3L4, RAB11B, VAMP2, CREB5, DYNLL2",0.393618634889395,0.146301788223826,FALSE +"A549","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.33062,-1.18,0.238,15995,0.766,"MAPK12, MAPKAPK2, PIK3R1, SHC2, MAPK14, PIK3CA, AKT1, PLA2G12A, MAPKAPK3, PLCG1, PIK3R3, PLA2G6, MAPK3, NFATC4, PLA2G4B, VEGFA, RAC2, MAPK13, PIK3R2",0.623423042943488,0.115771230367396,FALSE +"A549","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.21946,0.81,0.715,2529,0.812,"ATP6V1E2, TJP1, KDELR1, ACTG1, PRKX, ATP6V0E1, PRKCA, SLC12A2, SEC61A2, ACTB",0.145693958198919,0.0904439707588247,FALSE +"A549","Input","KEGG_VIRAL_MYOCARDITIS",0.20678,0.756,0.832,2529,0.901,"SGCD, EIF4G2, ACTG1, SGCA, CAV1, CASP8, ACTB",0.0798766737092761,0.045275209020937,FALSE +"A549","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.24656,-0.871,0.637,14908,0.815,"RAC3, CAMK2B, MAPK10, NFATC1, CCND2, JUN, PLCB2, PLCB1, DAAM2, AXIN2, CHD8, LRP5, FZD7, AXIN1, DVL2, RBX1, WNT10A, PPP2R5D, DVL1, EP300, PLCB3, SENP2, WNT2B, LEF1, WNT5A, FZD4, PRKACA, PRICKLE1, CREBBP, FRAT2, PORCN, PPP2R5B, FZD1, FRAT1, NFATC4, RAC2, CSNK2B, CTBP1, TBL1XR1, CSNK1E, PPARD, CTNNBIP1, DVL3",0.19586056766465,0.0888423912600234,FALSE +"H1703","Input","KEGG_ABC_TRANSPORTERS",-0.3575,-1.27,0.163,14274,0.559,"ABCB11, ABCC2, ABCA8, ABCC9, ABCA6, CFTR, ABCA4, ABCB4, ABCB9, ABCA13, ABCA12, ABCD3, ABCB1, ABCA10, ABCA1, ABCC1, ABCG2, ABCC6, ABCG1, ABCD4, ABCC3, ABCA5, ABCB6",0.787812395596042,0.252588192113577,FALSE +"H1703","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.38364,1.22,0.189,3007,0.567,"EIF4EBP1, STAT3, GRB2, FLT3, MTOR, CHUK, MAPK1, NFKB1, IKBKG, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, RPS6KB1",0.723538195826756,0.246416941107093,FALSE +"H1703","Input","KEGG_ADHERENS_JUNCTION",0.29159,0.946,0.533,3288,0.743,"RAC1, SMAD2, VCL, FGFR1, WASF1, MAP3K7, TGFBR2, EP300, MAPK1, CSNK2B, CTNNA1, SMAD4, AFDN, YES1, IQGAP1, WASF2, NLK, SSX2IP, NECTIN2, RHOA",0.273272790973428,0.129011186239425,FALSE +"H1703","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.39435,1.26,0.172,3697,0.579,"STAT3, ADIPOR2, MAPK9, SOCS3, PRKAG2, PRKAA1, NFKBIE, STK11, MAPK8, MTOR, PTPN11, TNFRSF1A, CHUK, NFKB1, IKBKG, AKT1, PCK2, LEPR, CPT1A, CAMKK2, AKT3, NFKBIB",0.764471553092451,0.237321436272564,FALSE +"H1703","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.25462,0.82,0.735,3341,0.829,"ADSL, CAD, ASNS, GOT1, NIT2, GLUD1, ASL",0.133712660915805,0.0814454694497265,FALSE +"H1703","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.17903,0.581,0.98,3422,1,"SGK1, NEDD4L, MAPK1, KRAS, ATP1A3, PRKCA",0.00877392430750515,0,FALSE +"H1703","Input","KEGG_ALLOGRAFT_REJECTION",0.24222,0.775,0.803,14486,0.884,"CD40, IL12B, IL5, IL12A, IFNG, CD28, CD40LG, IL2, FASLG, CD80, IL4, IL10, PRF1, TNF, FAS, CD86, GZMB",0.095284454721319,0.0535477349869269,FALSE +"H1703","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.47522,-1.78,0.0291,12060,0.363,"PLA2G2A, PLA2G5, PLA2G2C, PLA2G2F, PLA2G4B, PLA2G4E, PLA2G6, PLA2G3, ACOX1, PLA2G10, FADS2, PLA2G4A",1.53610701101409,0.440093374963888,FALSE +"H1703","Input","KEGG_ALZHEIMERS_DISEASE",0.27885,0.897,0.587,4485,0.777,"GRIN2B, NDUFS6, ITPR2, SDHA, APH1A, NDUFA9, ATP2A1, GAPDH, NDUFA1, ATP5F1A, COX7A2L, IDE, TNFRSF1A, PLCB3, CALML6, PLCB4, MAPK1, NDUFS4, NDUFA3, PPP3R2, CYCS, BID, CYC1, PPP3CB, ATP5F1D, SDHB, NAE1, NDUFS3, ADAM17, CALM3, NDUFA6, NDUFA10, NDUFB8, ATP2A3, ATP5F1C, UQCRHL, UQCRFS1, NDUFC1, PSEN2, BAD, LRP1",0.231361898752386,0.109578981199086,FALSE +"H1703","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.48167,1.56,0.0385,3842,0.429,"YARS2, RARS2, IARS2, HARS2, TARS2, FARSA, AARS2, FARS2",1.4145392704915,0.367542707815276,FALSE +"H1703","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.23372,-0.86,0.606,16354,0.742,"GCK, NPL, GFPT2, RENBP, GFPT1, MPI, GALE, UGDH, HK2, NAGK",0.217527375833714,0.129596094720973,FALSE +"H1703","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.34517,1.11,0.298,2986,0.598,"GRIN2B, MAPK11, NEFH, MAPK12, RAC1, DAXX, TNFRSF1A, PPP3R2, CYCS, BID, PPP3CB, MAPK14",0.525783735923745,0.223298816011589,FALSE +"H1703","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.45574,1.46,0.0663,3014,0.392,"NFYB, HSPA4, KLRC2, KLRC4, HSPA1L, HSP90AB1, TAP2, RFX5, KLRC3, TAP1, PSME3, NFYC, HSPA1A, TAPBP, RFXANK",1.17848647159523,0.406713932979543,FALSE +"H1703","Input","KEGG_APOPTOSIS",0.34432,1.12,0.268,5095,0.586,"MAP3K14, AIFM1, BIRC3, PRKAR2A, BIRC2, TNFRSF1A, DFFA, CHUK, PRKAR2B, NFKB1, IKBKG, AKT1, XIAP, PPP3R2, CYCS, RIPK1, IRAK1, BID, PPP3CB, PRKACA, AKT3, BAX, MYD88, TRAF2, NFKBIA, BAD, ATM, PIK3CB, IRAK2, PRKAR1B, IKBKB, EXOG, TRADD",0.571865205971211,0.232102383981909,FALSE +"H1703","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.44904,-1.59,0.0563,15113,0.378,"PTGIS, GGT6, CYP2J2, GGT5, PLA2G10, CYP4F3, ALOX5, PTGS1, GPX2, PTGS2, LTC4S, GPX3, GPX7, AKR1C3, PLA2G4A, TBXAS1, PTGES, EPHX2, GGT7, CBR3, GPX1",1.24949160514865,0.422508200162775,FALSE +"H1703","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.33675,-1.18,0.211,17949,0.53,"AGMAT, CPS1, CKMT1A, MAOA, CKMT1B, NAGS, ALDH2, ARG2, ASS1, SAT2",0.675717544702307,0.275724130399211,FALSE +"H1703","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.31601,-1.16,0.244,16215,0.546,"DSC2, CACNA1C, ITGA11, TCF7L2, CACNA2D3, CACNG6, RYR2, SLC8A1, CACNA1D, ITGB3, LEF1, ITGA7, ITGB6, DSG2, ITGA1, GJA1, ITGB4, ACTN4, ITGB8, ITGA2",0.612610173661271,0.262807357295263,FALSE +"H1703","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.23666,-0.86,0.658,18008,0.742,"UGDH, ALDH2",0.181774106386044,0.129596094720973,FALSE +"H1703","Input","KEGG_ASTHMA",0.2476,0.801,0.758,14383,0.848,"CD40, IL13, IL5, IL9, MS4A2, EPX, FCER1A, FCER1G, CD40LG, IL3, CCL11, IL4, IL10, TNF, PRG2, RNASE3",0.120330794367946,0.0716041477432862,FALSE +"H1703","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.28368,-1.06,0.332,9594,0.647,"IFNA4, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD28, CD40LG, IL2, TPO, FASLG, TSHB, CD80, IFNA13, IL4, CTLA4, IL10, IFNA21, TG, PRF1, TSHR, CGA, FAS, IFNA5, CD86, GZMB",0.478861916295964,0.1890957193313,FALSE +"H1703","Input","KEGG_AXON_GUIDANCE",-0.25682,-0.946,0.462,15670,0.703,"EPHA7, CXCL12, SEMA3G, ABLIM1, EPHB6, ROBO2, EPHA1, EPHA3, PLXNC1, EPHA5, PAK3, EPHA6, FES, SEMA6D, NTNG1, FYN, PLXNB1, SEMA4F, SEMA4A, ABLIM2, RND1, NFATC2, SLIT2, SEMA5A, SEMA7A, EPHB2, EFNB3, PAK6, HRAS, EPHA4, EPHB3, PLXNA2, SEMA3B, RAC2, NFATC4, NRP1, PLXNB3, ABLIM3, NTN4, EFNB2, PLXNA3, RGS3",0.335358024443874,0.153044674980176,FALSE +"H1703","Input","KEGG_BASAL_CELL_CARCINOMA",-0.225,-0.82,0.695,15333,0.802,"HHIP, PTCH1, WNT7B, TP53, WNT7A, SHH, WNT10A, TCF7L2, WNT11, WNT3, LEF1, FZD9, FZD4, FZD8, BMP2, WNT5A, FZD7, BMP4, GLI3, FZD3",0.158015195409886,0.0958256317158365,FALSE +"H1703","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.48489,1.56,0.0392,3630,0.429,"TAF9, TBP, GTF2H2, TAF9B, TAF1, TAF5, TAF4B, TAF6, TAF7, TAF2, TAF11, TBPL1, GTF2A1L, TAF5L, TAF1L, GTF2A2",1.40671393297954,0.367542707815276,FALSE +"H1703","Input","KEGG_BASE_EXCISION_REPAIR",0.51093,1.65,0.0291,7134,0.414,"OGG1, POLD2, POLD1, UNG, PARP1, NEIL2, POLL, POLE, LIG1, POLE2, MPG, MBD4, LIG3, NEIL3, NTHL1, PARP4, POLD3, TDG, NEIL1, POLE3, MUTYH, APEX2, FEN1, PARP3, HMGB1, POLB",1.53610701101409,0.382999658879101,FALSE +"H1703","Input","KEGG_BETA_ALANINE_METABOLISM",0.46985,1.52,0.0423,3228,0.413,"AOC2, AOC3, SMS, ALDH3A2, DPYS, HADHA, SRM, ALDH9A1",1.37365963262496,0.384049948343599,FALSE +"H1703","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.2599,-0.935,0.495,16509,0.695,"PECR, FADS2, HSD17B12, ACOT4, TECR, ELOVL6",0.305394801066431,0.158015195409886,FALSE +"H1703","Input","KEGG_BLADDER_CANCER",0.28469,0.931,0.542,2591,0.734,"VEGFD, E2F2, MAPK1, E2F3, E2F1, CDKN2A, KRAS, RAF1, NRAS, MAP2K2",0.266000713461613,0.134303940083929,FALSE +"H1703","Input","KEGG_BUTANOATE_METABOLISM",-0.3172,-1.18,0.213,17676,0.53,"ABAT, ACSM3, ALDH2, BDH2, BDH1, ACADS",0.671620396561262,0.275724130399211,FALSE +"H1703","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.36606,1.18,0.227,2705,0.568,"LILRB3, MALT1, NFATC1, RAC1, NFKBIE, GRB2, CHUK, MAPK1, NFKB1, IKBKG, AKT1, KRAS, PPP3R2, SOS1, RAF1, NRAS, MAP2K2, PPP3CB",0.643974142806877,0.245651664288981,FALSE +"H1703","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.25934,0.833,0.705,2936,0.828,"PDGFRA, TBXA2R, CACNA1A, GNAL, ITPR2, ATP2A1, PHKA1, CACNA1G, ADORA2A, VDAC2, HRH1, PPID, PLCE1, TRHR, PLCB3, CALML6, PLCB4, ADCY3, CACNA1H, VDAC1, SLC25A5, PPP3R2, CACNA1B, PPP3CB, PLCD4, PRKACA, PHKA2",0.151810883008601,0.0819696632151199,FALSE +"H1703","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.17124,0.555,0.984,6539,1,"CACNB1, SLC9A6, COX7A2L, TPM2, TPM3, CYC1, ATP1A3, CACNB4, CACNA2D1, UQCRHL, UQCRFS1, TNNC1, COX7C, UQCRC1, TPM1, UQCR11, COX6C, UQCRB, ATP1B3, UQCRC2, CACNB3, CACNG4, UQCR10, COX7B",0.00700490156865849,0,FALSE +"H1703","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.27553,-1.02,0.399,14211,0.609,"ITGAL, CD86, PECAM1, CDH15, ITGB2, CLDN10, CLDN2, CADM3, NRXN2, CLDN9, CLDN14, CD34, CLDN16, CDH5, NCAM2, VCAM1, SELL, JAM2, NLGN4X, CD6, CNTNAP2, MPZ, CD22, CLDN22, CD4, PDCD1LG2, CNTN1, NLGN1, CLDN11, SDC2, NRXN3, ICAM2, GLG1, NCAM1, CDH1, CLDN3, VCAN, CDH3, NRCAM, CD274, CLDN23, CADM1, NECTIN3, CLDN7, CLDN4, ICAM3, ITGB8, ICAM1, F11R",0.399027104313252,0.215382707367125,FALSE +"H1703","Input","KEGG_CELL_CYCLE",0.47154,1.5,0.0663,6373,0.401,"CCNB3, CCND2, SMAD2, MCM5, CHEK2, MAD2L2, ORC3, YWHAH, E2F2, MCM3, ESPL1, EP300, E2F3, ORC5, E2F1, CDKN2A, CDC25B, CDC45, HDAC2, YWHAE, CDC25A, SMAD4, CDC20, CCNB1, PRKDC, E2F5, SMC1B, CDC27, TTK, PTTG2, ANAPC1, ANAPC7, CCNA2, ANAPC4, CHEK1, FZR1, PKMYT1, RAD21, STAG2, CDC23, CDC6, MCM2, YWHAQ, RB1, TGFB1, PLK1, BUB1B, BUB1, ATM, CREBBP, CCNE2, SMC3, SMAD3, SMC1A, GADD45B, STAG1, CDKN1B, MAD2L1, CDK2, CCND3, TFDP1, MAD1L1, RBX1, YWHAG, MCM6, TFDP2, ATR, E2F4, CDC16, ABL1, MCM7, CDC7, CDK7, CDK1, ORC1, YWHAB, CDKN2C, YWHAZ, CDKN2B, PTTG1",1.17848647159523,0.396855627379818,FALSE +"H1703","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.26517,0.851,0.648,2894,0.807,"RAC1, CCR10, STAT3, SHC1, GRK3, ROCK1, GRK6, GNG13, GRB2, CCL28, CRKL, CCL2, PLCB3, XCL1, CHUK, PLCB4, ADCY3, CSK, MAPK1, CRK, NFKB1, IKBKG, AKT1, KRAS, SOS1, RAF1, CCL5, NRAS, GNB5, GNB2, ARRB2, GNB4, PRKACA",0.188424994129407,0.0931264652779296,FALSE +"H1703","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.37914,1.22,0.186,2591,0.567,"SHC1, GRB2, E2F2, CRKL, CBL, PTPN11, TGFBR2, CHUK, MAPK1, CRK, E2F3, NFKB1, E2F1, IKBKG, CDKN2A, AKT1, KRAS, HDAC2, SOS1, RAF1, CTBP1, NRAS, SMAD4, MAP2K2",0.730487055782084,0.246416941107093,FALSE +"H1703","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.36992,1.21,0.192,3869,0.538,"CLOCK, CRY1, PER3, CSNK1D, PER1, CSNK1E",0.71669877129645,0.269217724333611,FALSE +"H1703","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.33418,1.07,0.337,4539,0.613,"PDHA1, SDHA, ACO2, PCK2, SDHB, OGDH, ACLY, IDH3B, IDH3G, SUCLA2, IDH3A",0.472370099128661,0.212539525481585,FALSE +"H1703","Input","KEGG_COLORECTAL_CANCER",0.4612,1.49,0.063,5062,0.396,"APC2, RAC1, SMAD2, MAPK9, APC, MAPK8, TGFBR2, MAPK1, MSH6, AKT1, KRAS, MSH2, RAF1, SMAD4, CYCS, MLH1, RHOA, FOS, AKT3, BAX, TGFB1, MSH3, BAD, SMAD3, CTNNB1, PIK3CB, AXIN1, BIRC5, APPL1, AXIN2",1.20065945054642,0.402304814074488,FALSE +"H1703","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.33426,-1.2,0.231,14193,0.558,"C5, MASP1, C4A, SERPIND1, F10, VWF, KLKB1, PROC, A2M, PLAUR, SERPINA5, C4BPB, C1R, CFI, BDKRB1, SERPING1, SERPINA1, THBD, C2, CFB, CD46, C3, BDKRB2, CFH, CD55, PLAU, CD59, PLAT, F3",0.636388020107856,0.253365801062421,FALSE +"H1703","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.26228,0.863,0.655,2883,0.807,"SMS, GOT1, CBS, DNMT1, AHCY, LDHB, SRM, MPST",0.183758700008217,0.0931264652779296,FALSE +"H1703","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.20201,0.64,0.943,1765,0.988,"PDGFRA, VEGFD, FLT4, PDGFC, GHR, PDGFB, CCR10, IL17RA, TNFSF12, LIFR, BMPR1A, OSMR, IL13RA1, CCL28, FLT3, CCL2, TNFRSF1A, TGFBR2, XCL1, IFNAR2, IFNGR2, IL6ST",0.0254883072626717,0.00524305541237188,FALSE +"H1703","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.26593,0.857,0.644,4584,0.811,"POLR3C, POLR3G, CHUK, NFKB1, IKBKG, POLR1C, CCL5, RIPK1, POLR3H, POLR3GL, NFKBIB, POLR3A, POLR3K, NFKBIA, IKBKE, IRF3, IL18",0.191114132640188,0.090979145788844,FALSE +"H1703","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.22761,-0.847,0.685,15983,0.759,"ADCY4, TNNT2, CACNA1C, ITGA11, CACNA2D3, CACNG6, RYR2, SLC8A1, TNNI3, ADCY9, CACNA1D, ITGB3, TGFB3, ADCY7, ITGA7, ITGB6, ITGA1, ITGB4, TGFB2, ITGB8, ITGA2",0.164309428507574,0.11975822410452,FALSE +"H1703","Input","KEGG_DNA_REPLICATION",0.61996,2.01,0.00251,4068,0.141,"MCM5, RNASEH1, RPA1, POLA1, MCM3, POLD2, DNA2, RFC4, POLD1, PRIM2, RFC2, POLE, RNASEH2B, RFC1, LIG1, RNASEH2A, MCM2, POLE2",2.60032627851896,0.85078088734462,TRUE +"H1703","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.43423,1.41,0.0891,5357,0.468,"SPIRE1, ETS1, CPEB1, GRB2, MAPK1, KRAS, SOS1, NOTCH2, SPIRE2, EGFR, NOTCH3, ETV6, FMN2",1.05012229596313,0.329754146925876,FALSE +"H1703","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.25836,-0.942,0.516,14488,0.695,"CYP3A7, ADH1C, CYP2A6, GSTA1, GSTM2, UGT2B7, MAOB, CYP3A5, ALDH3B2, GSTM1, ALDH3A1, ALDH1A3, FMO4, AOX1, GSTT2, ALDH3B1, MAOA, MGST1, MGST2",0.287350298372789,0.158015195409886,FALSE +"H1703","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.19701,0.64,0.951,4066,0.988,"DPYS, HPRT1, UCK2, UPP2, IMPDH2, UMPS, GMPS, UPP1, CYP3A43",0.0218194830625861,0.00524305541237188,FALSE +"H1703","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.43845,-1.64,0.0619,14804,0.501,"CHAD, COL4A1, VWF, RELN, ITGA10, VTN, THBS2, CD36, COL11A1, THBS4, ITGA11, COL4A4, COL3A1, COL6A3, COL4A6, COL4A2, LAMA1, SDC2, HSPG2, COL1A2, ITGB3, SPP1, ITGA7, ITGB6, COL5A1, ITGA1, LAMA4, SV2A, ITGB4, LAMA3, LAMC2, COL6A1, COL1A1, THBS1, FN1, TNC, ITGB8, ITGA2, LAMB3, LAMB1, CD44",1.20830935097988,0.300162274132754,FALSE +"H1703","Input","KEGG_ENDOCYTOSIS",0.3005,0.978,0.459,4613,0.705,"PDGFRA, VTA1, GIT1, NEDD4, HSPA1L, PLD2, SMAP1, GRK3, PIP4K2B, GRK6, DNM1L, EPN2, NEDD4L, RAB31, PIP5K1A, SMURF2, CBL, RUFY1, SNF8, AP2B1, PDCD6IP, RAB4A, VPS4B, RAB5C, RAB11FIP2, ARRB2, STAM2, HSPA1A, RAB11B, ARFGAP3, RABEP1, IQSEC1, ACAP2, CLTB, AP2A1, ASAP1, SH3KBP1, RAB11FIP3, PARD6A, RBSN, CLTC, PRKCI, VPS36, RAB11A, RET, EPN1, CHMP3, SH3GLB2, CLTCL1, VPS45, PSD, CHMP4A, MVB12B, SH3GLB1, HSPA8, RAB11FIP1, CHMP6, CLTA, EGFR, HGS, FGFR3, HSPA1B",0.338187314462739,0.151810883008601,FALSE +"H1703","Input","KEGG_ENDOMETRIAL_CANCER",0.36401,1.17,0.209,5062,0.568,"APC2, APC, GRB2, MAPK1, AKT1, KRAS, SOS1, RAF1, CTNNA1, NRAS, MAP2K2, PTEN, MLH1, AKT3, BAD, EGFR, CTNNB1, PIK3CB, AXIN1, AXIN2",0.679853713888946,0.245651664288981,FALSE +"H1703","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.37919,1.21,0.2,2474,0.538,"MAPK11, ATP6V1E2, MAPK12, GIT1, RAC1, MAP3K14, MAPK9, MAPK8, ATP6V1C1, PTPN11, CHUK, CSK, HBEGF, NFKB1, IKBKG, CCL5, JAM3",0.698970004336019,0.269217724333611,FALSE +"H1703","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.31112,0.987,0.447,2591,0.702,"NRG2, EIF4EBP1, SHC1, PAK2, MAPK9, GRB2, CRKL, MAPK8, CBL, MTOR, MAPK1, CRK, HBEGF, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2",0.349692476868064,0.153662887870195,FALSE +"H1703","Input","KEGG_ETHER_LIPID_METABOLISM",0.27546,0.896,0.588,2722,0.77,"PLD2, PAFAH1B1, PAFAH1B3, CHPT1, LPCAT1, LPCAT4",0.230622673923862,0.113509274827518,FALSE +"H1703","Input","KEGG_FATTY_ACID_METABOLISM",0.23773,0.757,0.808,3816,0.906,"ALDH3A2, ECI1, HADHA, ADH5, ACAA2, CPT1A, ACADVL, ALDH9A1, ACAT1, HADHB, ACAT2",0.0925886392254138,0.0428718023231869,FALSE +"H1703","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.3071,0.982,0.451,3676,0.705,"MAPK11, MAPK12, RAC1, MAPK9, GRB2, MAPK8, MAPK1, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, MAPK14, PRKCA, AKT3, MAP2K3",0.345823458122039,0.151810883008601,FALSE +"H1703","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.21447,0.694,0.891,3567,0.978,"RAC1, PLD2, PIP4K2B, DNM1L, PIP5K1A, WASF1, CRKL, MAPK1, CRK, ARPC1B, VASP, AKT1, RAF1, RPS6KB1, WASF2, ASAP1, ARPC5, PRKCA, AKT3",0.0501222959631252,0.00966114521239857,FALSE +"H1703","Input","KEGG_FOCAL_ADHESION",0.25566,0.823,0.707,2361,0.831,"PDGFRA, LAMC3, VEGFD, FLT4, PDGFC, CCND2, PDGFB, RAC1, SHC1, PAK2, MAPK9, COL5A2, MYL12B, VCL, ROCK1, BIRC3, GRB2, CRKL, MAPK8, BIRC2, TLN1, MAPK1, CRK, LAMB2, RAPGEF1, VASP, AKT1, XIAP, SOS1, RAF1, CAV2",0.150580586203101,0.080398976215889,FALSE +"H1703","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.40759,-1.54,0.0553,15242,0.366,"ALPG, PTS, ALPP, QDPR",1.2572748686953,0.436518914605589,FALSE +"H1703","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.22928,-0.807,0.709,16156,0.814,"FBP1, AKR1B10, PFKFB4, MTMR7, MPI, HK2, ALDOC",0.149353764816933,0.0893755951107988,FALSE +"H1703","Input","KEGG_GALACTOSE_METABOLISM",-0.24419,-0.896,0.539,16354,0.72,"GCK, GLB1, B4GALT1, GALE, HK2, GAA",0.268411234813261,0.142667503568732,FALSE +"H1703","Input","KEGG_GAP_JUNCTION",0.32643,1.04,0.356,3882,0.653,"PDGFRA, PDGFC, PDGFB, ITPR2, TUBB3, GRB2, PLCB3, PLCB4, ADCY3, MAPK1, TUBB4A, KRAS, SOS1, RAF1, NRAS, MAP2K2, PRKACA, TUBB6, CSNK1D, PRKCA, TUBB, GNA11, TUBB2B, TUBB2A, GNAI2",0.448550002027125,0.185086818724926,FALSE +"H1703","Input","KEGG_GLIOMA",0.38173,1.23,0.171,3587,0.62,"PDGFRA, PDGFB, SHC1, GRB2, E2F2, MTOR, CALML6, MAPK1, E2F3, E2F1, CDKN2A, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, PTEN, PRKCA, AKT3, CALM3",0.767003889607846,0.207608310501746,FALSE +"H1703","Input","KEGG_GLUTATHIONE_METABOLISM",-0.30408,-1.07,0.355,16922,0.648,"GPX2, ANPEP, GPX3, GPX7, GSTT2, RRM1, GGT7, MGST1, MGST2, GPX1",0.449771646944906,0.188424994129407,FALSE +"H1703","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.27729,-1.04,0.364,18253,0.634,"DGKG, LIPG, GK, ALDH2, DGKA, PLPP3, MGLL",0.438898616350944,0.197910742118267,FALSE +"H1703","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.27262,0.888,0.608,4530,0.778,"PLD2, PEMT, GNPAT, AGPAT1, LPCAT3, LCLAT1, LPGAT1, CHPT1, DGKZ, ETNK1, LPCAT1, LPCAT4, ETNK2, PTDSS1, MBOAT2, DGKH, ACHE, PCYT1A, PGS1, GPAT3, DGKQ, AGPAT4",0.216096420727265,0.109020403010311,FALSE +"H1703","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.38859,1.26,0.168,4438,0.579,"AOC2, AOC3, CBS, PSAT1, GCAT, PHGDH, PSPH, SRR, AMT, ALAS1",0.774690718274137,0.237321436272564,FALSE +"H1703","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.27207,-0.982,0.437,16071,0.675,"LDHC, ALDH3B2, FBP1, GCK, AKR1A1, ALDH3A1, LDHAL6B, ALDH1A3, LDHA, ALDH3B1, HK2, ACSS1, ALDOC, ALDH2, GALM, ACSS2, ENO2",0.359518563029578,0.170696227168975,FALSE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.28899,0.944,0.514,2370,0.739,"CHST7, CHST13, CSGALNACT2, CHST3, B3GAT1",0.289036881004724,0.131355561605174,FALSE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.36305,-1.36,0.123,14466,0.565,"EXTL1, HS6ST3, HS6ST1, HS3ST5, NDST3, GLCE, EXT1, HS3ST3B1, HS3ST1, B3GALT6, EXTL3, EXTL2, EXT2",0.910094888560602,0.247951552180562,FALSE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.55485,-2.02,0.0206,17207,0.256,"B3GNT7, B4GALT1, CHST6, B4GALT3, ST3GAL1, B4GAT1, B4GALT4",1.68613277963085,0.59176003468815,FALSE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.35272,-1.31,0.115,14399,0.544,"HYAL1, GNS, HEXA, GLB1, HGSNAT, HS3ST3B1, HPSE, NAGLU",0.939302159646388,0.26440110030182,FALSE +"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.36302,-1.32,0.116,15441,0.56,"HEXA, SLC33A1, ST6GALNAC3, GLB1, ST8SIA1, ST6GALNAC5, ST3GAL1, ST3GAL5",0.935542010773082,0.2518119729938,FALSE +"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.44206,-1.61,0.0435,16571,0.403,"FUT2, ST8SIA1, B3GALT5, GBGT1, ST3GAL1, FUT1, B3GALNT1",1.36151074304536,0.39469495385889,FALSE +"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.55655,-2.07,0.0104,14036,0.415,"FUT9, B3GALT2, FUT7, ST3GAL6, B3GALT1, ABO, FUT2, FUT3, ST8SIA1, B3GALT5, B4GALT1, B4GALT3, B3GNT3, FUT1, B4GAT1, B4GALT4, B3GNT5",1.98296666070122,0.381951903287907,FALSE +"H1703","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.28154,-1.04,0.341,17741,0.634,"PIGM, PGAP1, PIGP, PIGH",0.467245621007502,0.197910742118267,FALSE +"H1703","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.47917,1.54,0.045,4607,0.435,"MTHFD1L, ACO2, MTHFD2, PGP, MTHFD1, GRHPR",1.34678748622466,0.361510743045363,FALSE +"H1703","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.34007,1.08,0.335,3676,0.628,"MAPK11, MAPK12, ITPR2, PLD2, MAPK9, GRB2, GNRH2, MAPK8, PLCB3, CALML6, PLCB4, ADCY3, MAPK1, HBEGF, MAP3K4, KRAS, SOS1, RAF1, NRAS, MAP2K2, PRKACA, MAPK14, ATF4, PRKCA, CALM3, GNA11, MAP2K3",0.474955192963155,0.202040356262804,FALSE +"H1703","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.50601,-1.84,0.00505,9878,0.373,"KLRD1, IFNG, KIR2DL1, CD28, KIR3DL2, IL2, KIR3DL1, KIR2DL3, FASLG, CD80, PRF1, TNF, FAS, CD86, GZMB, IL1A, IL6, IL1B",2.29670862188134,0.428291168191312,FALSE +"H1703","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.33871,1.09,0.315,4313,0.614,"GLI1, BTRC, WNT5B, BMP6, RAB23, FBXW11, PTCH2, CSNK1A1, WNT6, PRKACA, BMP7, CSNK1D, CSNK1G3, ZIC2, CSNK1E, STK36, BMP8A, WNT2B",0.501689446210399,0.211831628858832,FALSE +"H1703","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.35053,-1.28,0.152,15494,0.572,"KIT, CSF1R, CD36, FCGR1A, KITLG, CSF2, CD22, CD4, IL1A, IL6, IL1B, IL1R2, ANPEP, CD14, CSF2RA, ITGB3, IL11, ITGA1, IL6R, CD55, CD59, ITGA2, FLT3LG, CD44",0.818156412055227,0.242603971206976,FALSE +"H1703","Input","KEGG_HISTIDINE_METABOLISM",-0.2891,-1.08,0.276,14856,0.648,"ACY3, AOC1, DDC, HEMK1, MAOB, ALDH3B2, ALDH3A1, ALDH1A3, LCMT2, ALDH3B1, MAOA, HNMT, ALDH2",0.559090917934782,0.188424994129407,FALSE +"H1703","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.58066,1.86,0.00719,6162,0.21,"RPA1, RAD52, POLD2, RAD50, POLD1, RAD51, MUS81, MRE11, RAD54L, XRCC3, RAD51D, BRCA2, NBN, XRCC2, RAD54B, BLM, TOP3B, SEM1, EME1, RAD51C, POLD3",2.14327110961712,0.677780705266081,TRUE +"H1703","Input","KEGG_HUNTINGTONS_DISEASE",0.32908,1.07,0.332,4251,0.613,"GRIN2B, NDUFS6, SDHA, NDUFA9, TBP, DLG4, TFAM, NDUFA1, ATP5F1A, VDAC2, TAF4B, COX7A2L, PPID, HIP1, POLR2J, PLCB3, EP300, AP2B1, PLCB4, TBPL1, NDUFS4, VDAC1, NDUFA3, POLR2E, SLC25A5, HDAC2, CYCS, SIN3A, CYC1, ATP5F1D, POLR2H, SDHB, POLR2F, TGM2, CLTB, AP2A1, POLR2B, NDUFS3, POLR2J2, SP1, NDUFA6, BAX, SOD2, NDUFA10, CLTC, NDUFB8, ATP5F1C, UQCRHL, CLTCL1, UQCRFS1, NDUFC1, DCTN1, POLR2A",0.478861916295964,0.212539525481585,FALSE +"H1703","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.24638,-0.872,0.643,16198,0.76,"TNNT2, CACNA1C, ITGA11, CACNA2D3, CACNG6, RYR2, PRKAB1, SLC8A1, TNNI3, IL6, CACNA1D, ITGB3, ACE, TGFB3, ITGA7, ITGB6, ITGA1, ITGB4, TGFB2, ITGB8, ITGA2",0.191789027075778,0.119186407719209,FALSE +"H1703","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.36842,1.19,0.227,4909,0.558,"OCRL, PIP4K2B, IMPA1, PIP5K1A, INPP5B, TPI1, PLCE1, PI4KB, PLCB3, PLCB4, INPP4B, PLCD4, PTEN, PIK3C3, INPP5J, ISYNA1, INPPL1, PLCG2, INPP5E, PIK3CB, IPMK",0.643974142806877,0.253365801062421,FALSE +"H1703","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.34774,1.12,0.275,5499,0.586,"EIF4EBP1, SHC1, MAPK9, SOCS3, PRKAG2, PRKAA1, PHKA1, GRB2, PRKAR2A, CRKL, MAPK8, CBL, MTOR, FLOT1, CALML6, MAPK1, CRK, PRKAR2B, HK3, RAPGEF1, AKT1, KRAS, SOS1, RAF1, NRAS, RHOQ, ACACA, MAP2K2, PCK2, PRKACA, SOCS2, PHKA2, RPS6KB1, FLOT2, MKNK2, TRIP10, AKT3, CALM3, PRKCI, SREBF1, PPP1CC, BAD, EXOC7, FASN, PIK3CB, G6PC2, PRKAR1B, PDE3B, IKBKB, PYGL, RPTOR, TSC2, CALM1, ACACB, SH2B2, PRKAR1A, PRKCZ",0.560667306169737,0.232102383981909,FALSE +"H1703","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.29937,0.954,0.521,2595,0.734,"CCR10, MAP3K14, CCL28, CD40, MADCAM1",0.283162276700476,0.134303940083929,FALSE +"H1703","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.28043,0.902,0.587,2964,0.774,"CCND2, GHR, STAT3, PIAS3, LIFR, SOCS3, OSMR, IL13RA1, GRB2, CBL, PTPN11, EP300, IFNAR2, IFNGR2, IL6ST, SOCS7, PIAS2, LIF, TYK2, AKT1, SOS1, STAM2, SPRY3, SPRY4, IFNW1, SOCS2, LEPR",0.231361898752386,0.111259039317107,FALSE +"H1703","Input","KEGG_LEISHMANIA_INFECTION",0.29456,0.942,0.51,4257,0.735,"MAPK11, MAPK12, ITGAM, MAP3K7, IFNGR2, MAPK1, NFKB1, TAB1, IRAK1, MAPK14, JAK1, FOS, NFKBIB, TAB2, TGFB1, MYD88, NFKBIA",0.292429823902064,0.133712660915805,FALSE +"H1703","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.19966,0.64,0.938,4070,0.988,"MAPK11, MAPK12, RAC1, ITGAM, MYL12B, VCL, ROCK1, THY1, PTPN11, VASP, OCLN, CTNNA1, JAM3, AFDN, CLDN15, MAPK14, MYL12A, RHOA, PRKCA, PXN, MSN, GNAI2, BCAR1, SIPA1",0.0277971616209356,0.00524305541237188,FALSE +"H1703","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.39056,1.25,0.168,4604,0.586,"ALDH3A2, HADHA, ALDH9A1, ALDH1B1",0.774690718274137,0.232102383981909,FALSE +"H1703","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.27636,-1.03,0.353,11712,0.621,"CYP1A2, PLA2G2A, PLA2G5, PLA2G2C, CYP2E1, PLA2G2F, PLA2G4B, ALOX15, PLA2G4E, PLA2G6, CYP3A7, PLA2G3, CYP2J2, PLA2G10, CYP3A5, AKR1B10, PLA2G4A",0.452225294612177,0.20690839982342,FALSE +"H1703","Input","KEGG_LONG_TERM_DEPRESSION",0.28316,0.912,0.567,2591,0.769,"CACNA1A, ITPR2, PPP2CA, GNA13, PLCB3, PLCB4, MAPK1, GNAZ, KRAS, RAF1, NRAS, MAP2K2",0.246416941107093,0.114073660198569,FALSE +"H1703","Input","KEGG_LONG_TERM_POTENTIATION",0.35671,1.16,0.23,3587,0.58,"GRIN2B, ITPR2, RPS6KA6, PLCB3, EP300, CALML6, PLCB4, MAPK1, KRAS, PPP3R2, RAF1, NRAS, MAP2K2, PPP3CB, PRKACA, ATF4, PRKCA, CALM3",0.638272163982407,0.236572006437063,FALSE +"H1703","Input","KEGG_LYSINE_DEGRADATION",0.3071,0.998,0.437,4958,0.687,"NSD3, ALDH3A2, HADHA, SETD2, NSD2, NSD1, TMLHE, SETDB2, ALDH9A1, OGDH, ACAT1, ACAT2, EHMT2, ALDH1B1, KMT5A, DOT1L",0.359518563029578,0.16304326294045,FALSE +"H1703","Input","KEGG_LYSOSOME",-0.28575,-1.1,0.312,15828,0.627,"ATP6V0B, ATP6V0D1, GBA, SCARB2, ATP6V0A4, ABCB9, SORT1, LAPTM5, ACP5, GLB1, PLA2G15, HGSNAT, SLC11A2, CTSC, CTSB, CTSS, ATP6V1H, NEU1, AP1S3, NAGLU, CTSD, NPC2, CD63, GAA, FUCA1, ENTPD4, AP1M2, TPP1, MANBA, AP3S2, SMPD1, CTSH, ASAH1, CTSZ",0.505845405981557,0.202732459169284,FALSE +"H1703","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.39106,1.27,0.158,3426,0.59,"PDGFRA, MAPK11, CACNA1A, FGF17, MAP3K20, PDGFB, NFKB2, MAPK12, RAC1, MEF2C, MAP3K14, RPS6KA6, MAPK8IP2, PAK2, CACNB1, HSPA1L, MAPK9, RELB, SRF, FGF2, FGF5, CACNA1G, FGFR1, MAP3K12, PPM1B, MAP3K7, DAXX, GRB2, ELK4, HSPB1, CRKL, MAPK8, TNFRSF1A, TGFBR2, FGF12, DUSP16, CHUK, CACNA1H, MAPK1, CRK, RPS6KA4, NFKB1, IKBKG, MAP3K4, CDC25B, TAB1, MAP4K2, AKT1, TAOK1, KRAS, FGF8, PPP3R2, SOS1, RAF1, NRAS, STK3, CACNA1B, ARRB2, MAP2K2, RRAS, HSPA1A, PPP3CB, MRAS, MAPK8IP1, PRKACA, NF1, MAPK14, NLK, MKNK2, ATF4, MAP3K6, FOS, PRKCA, CACNB4",0.801342913045577,0.229147988357856,FALSE +"H1703","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.37293,-1.39,0.0978,14279,0.543,"NR5A2, HNF4A, ONECUT1, FOXA3, HNF1B, BHLHA15, GCK, HNF4G, FOXA2, PAX6, HES1",1.0096611452124,0.265200170411153,FALSE +"H1703","Input","KEGG_MELANOGENESIS",-0.20407,-0.76,0.839,15276,0.86,"EDNRB, CAMK2B, CAMK2A, KIT, TYRP1, WNT7B, WNT7A, ADCY4, KITLG, WNT10A, TCF7L2, WNT11, WNT3, ADCY9, CREB3L4, LEF1, ADCY7, FZD9, MITF, FZD4, CREB3L1, FZD8, PLCB2, WNT5A, FZD7, EDN1, HRAS, PLCB1, CREB3L2, FZD3",0.0762380391712997,0.0655015487564323,FALSE +"H1703","Input","KEGG_MELANOMA",0.42035,1.35,0.106,2759,0.514,"PDGFRA, FGF17, PDGFC, PDGFB, FGF2, FGF5, FGFR1, E2F2, FGF12, MAPK1, E2F3, E2F1, CDKN2A, AKT1, KRAS, FGF8, RAF1, NRAS, MAP2K2, PTEN",0.97469413473523,0.289036881004724,FALSE +"H1703","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.31784,-1.19,0.243,14488,0.554,"CYP3A7, ADH1C, GSTA1, DHDH, GSTM2, UGT2B7, CYP3A5, ALDH3B2, AKR1C1, GSTM1, ALDH3A1, ALDH1A3, AKR1C2, CYP1B1, GSTT2, AKR1C3, ALDH3B1, CYP1A1, CYP2S1, MGST1, MGST2",0.614393726401688,0.25649023527157,FALSE +"H1703","Input","KEGG_MISMATCH_REPAIR",0.66301,2.13,0.00513,4127,0.179,"PMS2, RPA1, POLD2, MSH6, RFC4, POLD1, MSH2, RFC2, EXO1, MLH1, RFC1, LIG1, MSH3",2.28988263488818,0.747146969020107,TRUE +"H1703","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.39377,1.27,0.146,3567,0.59,"VEGFD, EIF4EBP1, RPS6KA6, PRKAA1, STK11, ULK2, MTOR, MAPK1, AKT1, ULK1, RPS6KB1, MLST8, RICTOR, AKT3",0.835647144215563,0.229147988357856,FALSE +"H1703","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.28633,0.911,0.572,2705,0.763,"KLRK1, NFATC1, RAC1, KLRC2, SHC1, KLRC3, MICA, GRB2, PTPN11, IFNAR2, IFNGR2, MAPK1, MICB, KRAS, PPP3R2, SOS1, RAF1, NRAS, MAP2K2, BID, PPP3CB",0.242603971206976,0.11747546204512,FALSE +"H1703","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.26553,0.863,0.644,1739,0.807,"GRIN2B, GRIN3B, S1PR1, GABRD, TBXA2R, CHRM4, GHR, C5AR1, AVPR2, P2RY4, GABRQ, S1PR5, GHSR, MC5R, ADORA2A, HRH1, LPAR2, GABRR2, TRHR, TRPV1, PTGER4, CRHR2, GRM6, GABBR1, CHRNA5",0.191114132640188,0.0931264652779296,FALSE +"H1703","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.35215,1.13,0.275,5783,0.604,"MAPK11, MAPK12, RAC1, SHC1, RPS6KA6, MAPK9, NFKBIE, YWHAH, GRB2, CRKL, MAPK8, PTPN11, CALML6, CSK, MAPK1, CRK, RPS6KA4, NFKB1, RAPGEF1, AKT1, KRAS, YWHAE, SOS1, RAF1, NRAS, IRAK1, MAP2K2, MAPK14, RHOA, ATF4, AKT3, CALM3, BAX, NFKBIB, YWHAQ, RIPK2, NFKBIA, PLCG2, BAD, CAMK2G, MAPK7, PIK3CB, IRAK2, IKBKB, ZNF274, YWHAG, CALM1, SH2B2, NTF4, CDC42, KIDINS220, ABL1, BEX3",0.560667306169737,0.218963061378868,FALSE +"H1703","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.23279,-0.869,0.596,14031,0.751,"QPRT, ENPP3, ENPP1, BST1, NMNAT2, AOX1, NMNAT3, NNT",0.224753740259764,0.124360062995832,FALSE +"H1703","Input","KEGG_NITROGEN_METABOLISM",-0.27506,-1.02,0.386,17266,0.609,"CA9, GLS2, CA12, CPS1, CTH",0.413412695328245,0.215382707367125,FALSE +"H1703","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.41774,1.33,0.11,3992,0.541,"NLRC4, MAPK11, MAPK12, MAPK9, HSP90AB1, ERBIN, BIRC3, MAP3K7, MAPK8, CCL2, BIRC2, CHUK, MAPK1, NFKB1, IKBKG, TAB1, XIAP, CCL5, MAPK14, SUGT1, NFKBIB, NAIP, TAB2, RIPK2",0.958607314841775,0.266802734893431,FALSE +"H1703","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.62191,2.03,0.00362,4017,0.182,"XRCC6, RAD50, PRKDC, MRE11, POLL, XRCC4, LIG4",2.44129142946683,0.739928612014925,TRUE +"H1703","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.31299,1,0.443,4830,0.691,"GRB2, E2F2, MAPK1, E2F3, E2F1, CDKN2A, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, PRKCA, AKT3, RB1, PLCG2, BAD, EGFR, PIK3CB",0.35359627377693,0.160521952625802,FALSE +"H1703","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.31269,1.01,0.406,4661,0.677,"APH1A, NUMBL, EP300, KAT2A, HDAC2, CTBP1, KAT2B, NOTCH2, DVL1, DVL2, MAML1, JAG2, ADAM17, NCOR2, CTBP2, DLL3, PSEN2, DVL3, CREBBP, NOTCH3, MFNG",0.391473966422806,0.169411331314856,FALSE +"H1703","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.43379,1.4,0.0916,6239,0.449,"GTF2H5, RPA1, GTF2H2, CUL4A, POLD2, RFC4, POLD1, RFC2, POLE, CUL4B, RFC1, LIG1, POLE2, ERCC2, ERCC8, CETN2, RBX1, RAD23A, CDK7, POLD3, ERCC1",1.03810452633215,0.347753658996677,FALSE +"H1703","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.26286,-0.949,0.459,17042,0.714,"ALG9, RPN2, B4GALT1, B4GALT3, MAN1C1, ALG10B, MAN1B1, MOGS, MAN1A1, DOLPP1",0.338187314462739,0.146301788223826,FALSE +"H1703","Input","KEGG_OLFACTORY_TRANSDUCTION",0.23183,0.742,0.817,700,0.921,"OR4A47, OR2V2, OR4S1, GNAL, OR2H2, OR2A5, GRK3, OR4F16",0.0877779434675845,0.0357403698031511,FALSE +"H1703","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.53985,1.74,0.0215,2373,0.292,"FTCD, MTHFD1L, ATIC, TYMS, GART, MTHFD2",1.66756154008439,0.534617148551582,FALSE +"H1703","Input","KEGG_OOCYTE_MEIOSIS",0.4335,1.4,0.0889,4685,0.449,"PPP2R5A, MAPK12, ITPR2, BTRC, RPS6KA6, PPP2CA, CPEB1, MAD2L2, YWHAH, ESPL1, FBXW11, FBXO43, CALML6, PPP2R5D, ADCY3, MAPK1, SLK, SGO1, PPP3R2, YWHAE, CDC20, CCNB1, PPP3CB, PRKACA, SMC1B, CDC27, PTTG2, PPP2R5E, ANAPC1, ANAPC7, ANAPC4, PKMYT1, CDC23, CALM3, YWHAQ, FBXO5, PLK1, PPP1CC, BUB1, CCNE2, SMC3, CAMK2G, SMC1A",1.05109823902979,0.347753658996677,FALSE +"H1703","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.4118,-1.55,0.0508,15441,0.388,"HEXA, GBA, GLB1, NEU1, FUCA1, MANBA",1.29413628771608,0.411168274405793,FALSE +"H1703","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.21251,0.684,0.924,4989,0.972,"ATP6V1E2, NDUFS6, SDHA, NDUFA9, NDUFA1, ATP5F1A, COX7A2L, ATP6V1C1, NDUFS4, COX15, NDUFA3, CYC1, COX10, ATP5F1D, SDHB, COX11, NDUFS3, NDUFA6, NDUFA10, NDUFB8, ATP5F1C, UQCRHL, UQCRFS1, NDUFC1, TCIRG1, ATP6V0A1, COX7C, ATP5PD, UQCRC1",0.0343280287798933,0.0123337350737254,FALSE +"H1703","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.33721,1.09,0.317,301,0.614,"GALNT8, GALNT13",0.498940737782249,0.211831628858832,FALSE +"H1703","Input","KEGG_P53_SIGNALING_PATHWAY",0.34936,1.14,0.257,5416,0.604,"CCNB3, ADGRB1, CCND2, CHEK2, SHISA5, TP53I3, EI24, CDKN2A, SERPINE1, CYCS, GTSE1, CCNB1, BID, PTEN, SESN2, RRM2, COP1, CHEK1, RRM2B, BAX, SIAH1, IGFBP3, ATM, CCNE2, STEAP3, GADD45B, CDK2, CCND3, TSC2, ATR",0.590066876668705,0.218963061378868,FALSE +"H1703","Input","KEGG_PANCREATIC_CANCER",0.4332,1.39,0.0847,2400,0.449,"VEGFD, RAC1, SMAD2, STAT3, MAPK9, RALBP1, E2F2, MAPK8, TGFBR2, CHUK, MAPK1, E2F3, NFKB1, E2F1, RAD51, IKBKG, CDKN2A, AKT1, KRAS, RAF1, SMAD4",1.07211658966929,0.347753658996677,FALSE +"H1703","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.18878,-0.714,0.905,14406,0.888,"ENPP3, VNN1, ENPP1, VNN2, DPYD, BCAT1",0.0433514207947967,0.051587034221399,FALSE +"H1703","Input","KEGG_PARKINSONS_DISEASE",0.2881,0.931,0.537,5778,0.734,"NDUFS6, UBE2G1, SDHA, NDUFA9, NDUFA1, ATP5F1A, VDAC2, COX7A2L, PPID, UBE2J1, UCHL1, NDUFS4, VDAC1, NDUFA3, SLC25A5, CYCS, CYC1, ATP5F1D, SDHB, NDUFS3, NDUFA6, NDUFA10, NDUFB8, ATP5F1C, UBE2J2, UBE2L3, UQCRHL, UQCRFS1, NDUFC1, UBE2G2, COX7C, ATP5PD, UQCRC1, UBB, UQCR11, NDUFV3, COX6C, VDAC3, UQCRB, ATP5MC1, NDUFAB1",0.270025714300444,0.134303940083929,FALSE +"H1703","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.25677,0.825,0.685,6351,0.835,"ROCK1, TUBB3, ARPC1B, TUBB4A, OCLN, NCL, TUBB6, RHOA, ARPC5, PRKCA, TUBB, TUBB2B, YWHAQ, TUBB2A, ARPC1A, CTNNB1, ROCK2, ACTB, CDC42, CLDN1, ABL1, TUBA1A, ITGB1, ARPC5L, YWHAZ",0.164309428507574,0.0783135245163979,FALSE +"H1703","Input","KEGG_PATHWAYS_IN_CANCER",0.29938,0.977,0.465,4615,0.698,"PDGFRA, LAMC3, FGF17, VEGFD, APC2, GLI1, PDGFB, NFKB2, RAC1, SMAD2, STAT3, WNT5B, PIAS3, ARNT, MAPK9, HSP90AB1, ETS1, RALBP1, FGF2, FGF5, FGFR1, BIRC3, TRAF3, APC, GRB2, FLT3, E2F2, CRKL, MAPK8, CBL, MTOR, EGLN1, BIRC2, PTCH2, TGFBR2, EP300, FGF12, VHL, CHUK, MAPK1, CRK, MSH6, E2F3, NFKB1, CCDC6, LAMB2, E2F1, RAD51, IKBKG, PIAS2, CDKN2A, TPM3, AKT1, XIAP, KRAS, FGF8, HDAC2, SOS1, MSH2, RAF1, CTNNA1, CTBP1, NRAS, SMAD4, CYCS, MAP2K2, BID, DVL1, PTEN, DVL2, WNT6, MLH1, RHOA, BRCA2, JAK1, FOS, PRKCA, AKT3, BAX, TRAF1, TRAF5, RB1, LAMA5, TGFB1, CTBP2, RET, STK36, MSH3, DAPK3, TRAF2, NFKBIA, WNT2B, DVL3, PLCG2, ELOC, BAD, CUL2, CREBBP, CCNE2, EGFR, SMAD3, CTNNB1, FGFR3, EGLN2",0.332547047110046,0.156144577376839,FALSE +"H1703","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.19084,-0.677,0.868,11600,0.92,"UGT2B4, UGT2B17, UGT2A3, UGT2A1, UGT2B15, UGP2, DHDH, UGT2B7, DCXR, UGDH",0.0614802748235081,0.0362121726544447,FALSE +"H1703","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.27662,-1.03,0.361,17989,0.621,"H6PD, ALDOC, TALDO1",0.442492798094342,0.20690839982342,FALSE +"H1703","Input","KEGG_PEROXISOME",0.21494,0.691,0.886,4109,0.973,"PEX5, PEX16, HACL1, SLC25A17, DECR2, GNPAT, PEX26, AMACR, MPV17, PHYH, PEX6, PEX3, PXMP2, ABCD2, SOD2, PXMP4, AGPS, CRAT",0.0525662781129492,0.0118871597316481,FALSE +"H1703","Input","KEGG_PHENYLALANINE_METABOLISM",0.37676,1.21,0.202,1522,0.538,"AOC2, AOC3, GOT1",0.694648630553376,0.269217724333611,FALSE +"H1703","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.34267,1.12,0.286,4486,0.586,"OCRL, ITPR2, PIP4K2B, IMPA1, PIP5K1A, INPP5B, PLCE1, PI4KB, PLCB3, CALML6, PLCB4, DGKZ, INPP4B, PLCD4, PTEN, PIK3C3, INPP5J, PRKCA, CALM3, INPPL1, DGKH, PLCG2, INPP5E, DGKQ",0.543633966870957,0.232102383981909,FALSE +"H1703","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.3162,1.03,0.411,3089,0.649,"HMOX1, FECH, COX15, COX10, FTH1",0.386158178123931,0.187755303199631,FALSE +"H1703","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.3797,-1.34,0.147,13054,0.559,"CYP8B1, CYP7A1, PCK1, APOA1, CPT1B, FABP1, ACSL1, HMGCS2, RXRG, ACSL6, FABP4, CYP4A22, DBI, APOA2, SLC27A6, ACSL3, FABP7, AQP7, EHHADH, ACOX1, LPL, PPARA, OLR1, SORBS1, ACADL, CD36, CYP27A1, FABP3, FADS2, SCP2, ILK, ACOX2, FABP6, ACSL5, CPT1C, SLC27A2, CPT2, GK, PLTP, ME1",0.832682665251824,0.252588192113577,FALSE +"H1703","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.32686,-1.21,0.194,16280,0.562,"CYP7B1, CYP27A1, SCP2, CYP39A1, ACOX2",0.712198270069774,0.250263684430939,FALSE +"H1703","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.37858,1.22,0.2,3722,0.567,"TAP2, RFX5, TAP1, IKBKG, ADA, UNG, CD40, RFXANK, RFXAP",0.698970004336019,0.246416941107093,FALSE +"H1703","Input","KEGG_PRION_DISEASES",0.1923,0.619,0.975,3665,0.994,"MAPK1, CCL5, MAP2K2, HSPA1A, PRKACA, BAX",0.0109953843014632,0.00261361560268669,FALSE +"H1703","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.45689,1.5,0.0456,3567,0.401,"CCNB3, MAPK11, MAPK12, RPS6KA6, MAPK9, HSP90AB1, CPEB1, MAD2L2, MAPK8, ADCY3, MAPK1, CDC25B, AKT1, KRAS, RAF1, CDC25A, CCNB1, PRKACA, CDC27, MAPK14, ANAPC1, ANAPC7, CCNA2, ANAPC4, FZR1, PKMYT1, CDC23, AKT3",1.34103515733556,0.396855627379818,FALSE +"H1703","Input","KEGG_PROPANOATE_METABOLISM",-0.39651,-1.4,0.103,16714,0.569,"HIBCH, LDHAL6B, ACSS3, LDHA, ABAT, ACSS1, MLYCD, ALDH2, MCEE, ACSS2, ALDH6A1",0.987162775294828,0.244887733604929,FALSE +"H1703","Input","KEGG_PROSTATE_CANCER",0.3573,1.15,0.249,2759,0.592,"PDGFRA, PDGFC, PDGFB, HSP90AB1, SRD5A2, FGFR1, GRB2, E2F2, MTOR, EP300, CHUK, MAPK1, E2F3, NFKB1, E2F1, IKBKG, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, PTEN",0.603800652904264,0.22767829327708,FALSE +"H1703","Input","KEGG_PROTEASOME",0.38944,1.27,0.162,5852,0.59,"PSMD4, PSMB4, PSMB9, PSME3, PSMC5, PSMD12, PSMF1, PSMD1, PSMA2, PSMD14, PSMD3, PSMB10, PSMD11, PSMD2, PSMA5, PSMB8, PSMA4, PSMC2, PSMB1, SEM1, PSME2",0.790484985457369,0.229147988357856,FALSE +"H1703","Input","KEGG_PROTEIN_EXPORT",0.37758,1.21,0.187,3938,0.538,"SEC63, SRP19, SRP9, SRP72, SEC61A2, SEC11C, SRP68, SRPRB",0.728158393463501,0.269217724333611,FALSE +"H1703","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.14865,0.485,0.997,4853,0.998,"PCK2, ATP1A3, GLUD1, SLC25A10, SLC9A3",0.00130484168834428,0.000869458712628891,FALSE +"H1703","Input","KEGG_PURINE_METABOLISM",0.36229,1.17,0.251,4293,0.568,"PDE4A, NT5C2, POLR3C, PFAS, ADSL, POLR3G, ADK, PRPS1, PDE6C, POLA1, ATIC, HPRT1, NME4, NME2, ENTPD8, POLR1E, POLD2, POLR2J, GART, ADCY3, POLD1, NME1, POLR1C, ADA, POLR2E, NUDT5, PRUNE1, PRIM2, AMPD2, NME6, POLR3H, IMPDH2, GUK1, POLR2H, POLR2F, RRM2, PDE9A, GMPS, POLE, ENTPD1, POLR2B, POLR2J2, DCK, POLR3GL, RRM2B, PDE10A, PAICS, POLR3A, POLR3K, POLE2, PAPSS2, NUDT2, POLR2A, NME3",0.600326278518962,0.245651664288981,FALSE +"H1703","Input","KEGG_PYRIMIDINE_METABOLISM",0.50444,1.62,0.0286,4293,0.423,"NT5C2, TXNRD1, POLR3C, POLR3G, CAD, POLA1, CTPS1, DPYS, NME4, NME2, TYMS, ENTPD8, POLR1E, POLD2, POLR2J, UCK2, POLD1, NME1, POLR1C, UPP2, POLR2E, PRIM2, NME6, POLR3H, UMPS, POLR2H, POLR2F, RRM2, DCTD, DUT, POLE, UPRT, ENTPD1, POLR2B, POLR2J2, DCK, POLR3GL, RRM2B, POLR3A, UPP1, POLR3K, POLE2, NUDT2, POLR2A, NME3",1.54363396687096,0.373659632624958,FALSE +"H1703","Input","KEGG_PYRUVATE_METABOLISM",-0.27456,-1.05,0.35,18483,0.649,"ACSS1, ALDH2, ACSS2, ME1, PC",0.455931955649724,0.187755303199631,FALSE +"H1703","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.34257,1.1,0.308,3352,0.611,"PDGFRA, FGF17, APC2, PDGFC, CHRM4, PDGFB, GIT1, RAC1, ITGAM, PFN1, PAK2, PFN4, ENAH, MYL12B, PIP4K2B, VCL, ROCK1, FGF2, FGF5, SSH1, FGFR1, PIP5K1A, WASF1, APC, GNA13, CRKL, FGF12, TMSB4Y, CSK, MAPK1, CRK, CYFIP1, ARPC1B, KRAS, FGF8, SOS1, RAF1, NRAS, MYH9, MAP2K2, RRAS, MRAS, FGD1, DIAPH3, IQGAP1, WASF2, MYL12A, DOCK1, RHOA, ARPC5",0.511449283499556,0.213958789757446,FALSE +"H1703","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.45818,1.47,0.0627,3091,0.413,"ATG5, ATG7, PRKAA1, ULK2, ULK1, GABARAPL1, BECN1, PIK3C3",1.20273245916928,0.384049948343599,FALSE +"H1703","Input","KEGG_RENAL_CELL_CARCINOMA",0.39768,1.29,0.148,2591,0.598,"VEGFD, PDGFB, RAC1, ARNT, PAK2, ETS1, GRB2, CRKL, EGLN1, PTPN11, EP300, VHL, MAPK1, CRK, RAPGEF1, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2",0.829738284605043,0.223298816011589,FALSE +"H1703","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.32245,1.04,0.365,1261,0.653,"NLN, LNPEP",0.437707135543525,0.185086818724926,FALSE +"H1703","Input","KEGG_RETINOL_METABOLISM",-0.22451,-0.797,0.668,11025,0.82,"UGT2B11, CYP4A11, DHRS4L2, ADH6, CYP2A13, ADH1B, RDH8, UGT2B4, ADH7, UGT2B17, CYP1A2, ADH1A, UGT2A3, AWAT2, UGT2A1, UGT2B15, CYP2A7, RDH10, CYP2B6, RPE65, CYP4A22, CYP3A7, ADH1C, CYP2A6, RDH16, RDH5, UGT2B7, RETSAT, DHRS9, CYP3A5, BCO1, LRAT, ALDH1A2, CYP1A1, CYP26B1, RDH11, DHRS3",0.175223537524454,0.0861861476162833,FALSE +"H1703","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.20606,-0.721,0.827,3935,0.908,"MTMR1, ACP6, MTMR6, RFK, ACP1, FLAD1, ACP2, ACP4, PHPT1, MTMR2, TYR, ENPP3, ENPP1, ACP5, MTMR7",0.0824944904474534,0.0419141514789149,FALSE +"H1703","Input","KEGG_RIBOSOME",-0.25121,-0.929,0.527,15661,0.678,"RPS8, RPL10A, RPL18, RPL7A, RPL35, RPL31, RPS3, RPL37A, RPL24, RPS15A, RPL29, RPS21, RPS6, RPS19, RPS27, RPS11, RPL13A, RPS9, RPLP2, RPS13, RPL27A",0.278189384787453,0.168770306132937,FALSE +"H1703","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.38127,1.22,0.186,4518,0.567,"MAPK11, MAPK12, ATG5, DDX3Y, MAPK9, MAP3K7, TRAF3, MAPK8, CHUK, TBKBP1, AZI2, NFKB1, IKBKG, RIPK1, IFNW1, MAPK14, TRIM25, DHX58, NFKBIB, TRAF2, NFKBIA, IKBKE, SIKE1, ATG12, IRF3",0.730487055782084,0.246416941107093,FALSE +"H1703","Input","KEGG_RNA_DEGRADATION",0.48273,1.53,0.0479,6697,0.424,"LSM1, EXOSC1, TENT4A, MTREX, HSPA9, EXOSC7, EXOSC3, DCP1B, CNOT10, LSM4, EDC4, ENO1, LSM2, EXOSC10, DCP2, EXOSC2, LSM6, EXOSC8, ZCCHC7, PAPOLB, LSM5, LSM3, PAPOLA, XRN1, SKIV2L, LSM7, EXOSC6, TTC37, EXOSC4, PARN, CNOT8, EXOSC9, CNOT9, XRN2, ENO3, CNOT1, PATL1, CNOT6",1.31966448658544,0.372634143407267,FALSE +"H1703","Input","KEGG_RNA_POLYMERASE",0.53681,1.75,0.0124,4251,0.325,"POLR3C, POLR3G, POLR1E, POLR2J, POLR1C, POLR2E, POLR3H, POLR2H, POLR2F, POLR2B, POLR2J2, POLR3GL, POLR3A, POLR3K, POLR2A",1.90657831483776,0.488116639021126,FALSE +"H1703","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.2498,0.806,0.735,4494,0.846,"SEPHS1, CBS, BUD23, AHCY, PAPSS2, METTL6, SCLY",0.133712660915805,0.0726296369609765,FALSE +"H1703","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.26392,0.855,0.657,6164,0.807,"LAMC3, PIAS3, BIRC3, TRAF3, E2F2, BIRC2, CHUK, E2F3, NFKB1, LAMB2, E2F1, IKBKG, PIAS2, AKT1, XIAP, CYCS, PTEN, AKT3, TRAF1, TRAF5, RB1, LAMA5, TRAF2, NFKBIA, CCNE2, PIK3CB, CDKN1B, IKBKB, CDK2, PIAS4, PIAS1, ITGAV, ITGA3, RELA, CKS1B, TRAF4, ITGB1",0.182434630440219,0.0931264652779296,FALSE +"H1703","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.3296,1.07,0.327,4551,0.613,"VAMP7, VAMP1, STX10, SNAP29, STX6, STX4, STX8, SNAP47, STX2, STX11, VTI1B, YKT6, GOSR2, VAMP2, STX1B, STX7",0.485452247339714,0.212539525481585,FALSE +"H1703","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.20482,-0.768,0.789,18902,0.859,"PLPP3, SMPD1, ASAH1",0.10292299679058,0.0660068361687577,FALSE +"H1703","Input","KEGG_SPLICEOSOME",0.58676,1.91,0.0123,4883,0.196,"MAGOHB, WBP11, SF3B4, TXNL4A, HSPA1L, PLRG1, RBM8A, PRPF8, THOC1, SNU13, RBM22, SNRPC, RBM17, SNRPD1, DHX16, HNRNPU, PRPF3, U2SURP, EFTUD2, DDX39B, ZMAT2, BUD31, SF3B5, ALYREF, PHF5A, SRSF1, HNRNPM, DDX46, PPIH, SF3A1, SNRPD3, LSM4, SRSF7, DDX42, CDC5L, SRSF3, CDC40, CCDC12, PPIL1, HSPA1A, SNRNP40, TCERG1, HNRNPA3, RBM25, LSM2, PUF60, THOC2, PRPF18, SMNDC1, LSM6, U2AF2, PRPF31, SNRPE, SRSF9, LSM5, TRA2A, NCBP1, DHX38, SART1, PRPF40A, PRPF40B, HSPA8, LSM3, U2AF1, SRSF2, HSPA1B, EIF4A3, SRSF4, AQR, SNRNP70, PRPF4, PQBP1",1.9100948885606,0.707743928643524,TRUE +"H1703","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.33823,-1.25,0.158,11025,0.537,"UGT2B11, AMY1C, AMY1A, PGM2, GBE1, UGT2B4, UGT2B17, MGAM, UGT2A3, UGT2A1, AMY2B, UGT2B15, PYGB, UXS1, PYGM, GYS1, TREH, UGP2, GANC, ENPP3, ENPP1, AGL, UGT2B7, GCK, UGDH, HK2, PGM2L1, GAA",0.801342913045577,0.270025714300444,FALSE +"H1703","Input","KEGG_STEROID_BIOSYNTHESIS",0.34437,1.13,0.274,1535,0.604,"SOAT1, CYP27B1, NSDHL",0.562249437179612,0.218963061378868,FALSE +"H1703","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.31975,-1.23,0.175,15701,0.548,"CYP19A1, UGT2B7, CYP11A1, CYP3A5, AKR1C1, CYP7B1, HSD17B2, HSD11B2, HSD17B7, AKR1C2, STS, CYP1B1, HSD17B12, AKR1C3, CYP1A1, HSD17B8",0.756961951313706,0.261219441515631,FALSE +"H1703","Input","KEGG_SULFUR_METABOLISM",-0.25162,-0.912,0.518,16233,0.701,"BPNT1, SULT1A2, SULT1A4, SULT1A1",0.285670240254767,0.154281982033341,FALSE +"H1703","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.33097,1.06,0.345,2327,0.626,"GRIN2B, ELANE, SNRPD1, CD40, SNRPD3",0.462180904926726,0.20342566678957,FALSE +"H1703","Input","KEGG_TASTE_TRANSDUCTION",0.49432,1.59,0.0418,1140,0.443,"TAS2R9, TAS2R7, TAS2R10, CACNA1A, TAS2R8, GNG13, TAS2R13",1.37882371822496,0.35359627377693,FALSE +"H1703","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.45807,-1.61,0.0406,15251,0.403,"GGT6, GGT5, CDO1, GGT7",1.39147396642281,0.39469495385889,FALSE +"H1703","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.34401,1.12,0.293,4402,0.586,"PDSS2, ACAT1, ACAT2, GGPS1, HMGCS1",0.533132379645891,0.232102383981909,FALSE +"H1703","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28573,0.934,0.541,5434,0.744,"SMAD2, NOG, BMPR1A, PPP2CA, ROCK1, BMP6, SMURF2, TGFBR2, EP300, MAPK1, SMAD4, SMAD1, CHRD, ZFYVE16, E2F5, BMP7, RPS6KB1, RHOA, SP1, ID3, TGFB1, BMP8A, CREBBP, SMAD3, SMURF1, SMAD5, ID1, ROCK2, BMPR2, TFDP1, RBX1, E2F4",0.266802734893431,0.128427064454121,FALSE +"H1703","Input","KEGG_THYROID_CANCER",0.2996,0.962,0.493,2591,0.724,"MAPK1, CCDC6, TPM3, KRAS, NRAS, MAP2K2",0.30715308072277,0.140261433802853,FALSE +"H1703","Input","KEGG_TIGHT_JUNCTION",0.26716,0.847,0.671,4727,0.807,"MYH2, MAP3K20, PPP2R2C, EXOC3, MYL12B, PPP2CA, VAPA, TJAP1, YBX3, AKT1, KRAS, OCLN, CSNK2B, CTNNA1, NRAS, MYH3, JAM3, MYH9, RRAS, AFDN, MRAS, PTEN, CLDN15, YES1, RAB3B, MYL12A, RHOA, EPB41L2, PRKCA, PARD6A, AKT3, PRKCI, GNAI2, MYH1, LLGL1, MYH10, SYMPK, PRKCQ, CTNNB1, CGN",0.173277479831008,0.0931264652779296,FALSE +"H1703","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.31496,1.03,0.383,4518,0.649,"MAPK11, MAPK12, RAC1, MAPK9, MAP3K7, TRAF3, MAPK8, IFNAR2, CHUK, MAPK1, NFKB1, IKBKG, TAB1, CD40, AKT1, CCL5, RIPK1, IRAK1, MAP2K2, MAPK14, TICAM1, FOS, AKT3, MAP2K3, TAB2, MYD88, CTSK, NFKBIA, IKBKE, IRF5, IRF3",0.416801226031377,0.187755303199631,FALSE +"H1703","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.29761,-1.13,0.233,14864,0.584,"EHHADH, AADAT, AOC1, AFMID, IDO1, DDC, IL4I1, KMO, MAOB, OGDHL, AOX1, CYP1B1, CYP1A1, MAOA, ALDH2, CAT",0.632644078973981,0.233587152887601,FALSE +"H1703","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.36991,1.22,0.19,3347,0.567,"CACNA1A, MAPK9, SOCS3, CACNA1G, MAPK8, MTOR, MAPK1, HK3, CACNA1B, SOCS2, MAFA",0.721246399047171,0.246416941107093,FALSE +"H1703","Input","KEGG_TYPE_I_DIABETES_MELLITUS",-0.25506,-0.929,0.508,14053,0.678,"TNF, FAS, CD86, CPE, GZMB, IL1A, PTPRN2, IL1B",0.294136287716081,0.168770306132937,FALSE +"H1703","Input","KEGG_TYROSINE_METABOLISM",0.27013,0.875,0.624,1909,0.798,"AOC2, AOC3, GOT1, BUD23, ADH5",0.204815410317576,0.0979971086492706,FALSE +"H1703","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.37218,1.19,0.21,3697,0.558,"MALT1, MAPK11, MAPK12, NFATC1, MAP3K14, PAK2, MAPK9, NFKBIE, MAP3K7, GRB2, CBL, CHUK, MAPK1, NFKB1, IKBKG, AKT1, KRAS, PPP3R2, SOS1, RAF1, NRAS, MAP2K2, PPP3CB, MAPK14, RHOA, FOS, AKT3, NFKBIB",0.677780705266081,0.253365801062421,FALSE +"H1703","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.39987,1.29,0.145,5645,0.598,"HERC4, UBE2G1, BTRC, NEDD4, TRIM37, PIAS3, FBXO2, SOCS3, UBE2K, NEDD4L, UBE2D2, BIRC3, SMURF2, TRIP12, UBE2A, CUL4A, CBL, FBXW11, BIRC2, CDC34, VHL, UBE2J1, PIAS2, BRCA1, XIAP, CDC20, BIRC6, UBE2R2, UBA2, CDC27, UBE2D1, COP1, UBE2Z, ANAPC1, NHLRC1, CUL4B, ANAPC7, ANAPC4, FZR1, PPIL2, CDC23, UBE2E1, UBE2E2, SIAH1, UBE2S, UBE2J2, UBE2L3, UBE2Q1, CUL7, ELOC, CUL2, UBE2B, UBE2G2, SMURF1, ERCC8, UBE2M, UBE4B, UBR5, ELOB, RBX1, PIAS4, FBXW7, UBE2D4, PIAS1, CDC16, ITCH, UBE2D3, CUL3",0.838631997765025,0.223298816011589,FALSE +"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.45454,1.46,0.0647,4778,0.392,"PDHA1, IARS2, BCAT2, VARS2",1.1890957193313,0.406713932979543,FALSE +"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.33547,-1.26,0.16,17618,0.548,"AOX1, ABAT, DBT, BCAT1, ALDH2, MCEE, ACADS, ALDH6A1",0.795880017344075,0.261219441515631,FALSE +"H1703","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.1626,0.524,0.998,3616,1,"ITPR2, KCNMA1, ROCK1, ADORA2A, GNA13, PLCB3, CALML6, PLCB4, ADCY3, MAPK1, RAF1, MAP2K2, PRKACA, RHOA, PRKCA, CALM3, GNA11",0.000869458712628891,0,FALSE +"H1703","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.27399,-0.98,0.444,17000,0.663,"RAB5B, ADCY9, CREB3L4, CREB3L1, DYNC1I1, AQP3, CREB5, ARHGDIB, CREB3L2, DCTN6",0.35261702988538,0.178486471595227,FALSE +"H1703","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.33163,1.07,0.329,4409,0.613,"MAPK11, MAPK12, NFATC1, RAC1, HSPB1, MAPK1, AKT1, KRAS, PPP3R2, RAF1, NRAS, MAP2K2, PPP3CB, MAPK14, PRKCA, AKT3, PXN, NFAT5, PLCG2, BAD",0.482804102050026,0.212539525481585,FALSE +"H1703","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.19574,-0.715,0.888,15082,0.902,"ATP6V0D2, CFTR, ATP6V1C2, ATP6V1G1, ATP6V1F, PDIA4, ATP6V0B, ATP6V0D1, PLCG1, ATP6V0A4, SEC61B, ADCY9, ATP6V1H, ATP6V1A, ATP6V1B2, TJP2",0.051587034221399,0.0447934624580583,FALSE +"H1703","Input","KEGG_VIRAL_MYOCARDITIS",0.31847,1.01,0.429,2602,0.677,"MYH2, RAC1, CXADR, DAG1, CD40, CYCS, MYH3, MYH9, EIF4G1, BID",0.367542707815276,0.169411331314856,FALSE +"H1703","Input","KEGG_WNT_SIGNALING_PATHWAY",0.31753,1.03,0.389,3422,0.649,"APC2, CCND2, PPP2R5A, NFATC1, RAC1, SMAD2, BTRC, WNT5B, MAPK9, PPP2CA, ROCK1, NKD2, RUVBL1, MAP3K7, APC, MAPK8, FBXW11, PLCB3, EP300, PPP2R5D, PLCB4, CACYBP, CSNK1A1, PPP3R2, LRP6, CSNK2B, CTBP1, VANGL1, SMAD4, DVL1, PPP3CB, DVL2, WNT6, PRKACA, PPP2R5E, NLK, RHOA, PRKCA",0.410050398674292,0.187755303199631,FALSE +"HCC15","Input","KEGG_ABC_TRANSPORTERS",0.44979,1.42,0.0792,2887,0.378,"ABCG2, ABCC2, ABCG1, ABCB10, ABCC1, ABCC3, ABCB6, ABCA3, ABCD1, ABCC6, ABCA7",1.10127481841051,0.422508200162775,FALSE +"HCC15","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.28805,0.911,0.582,5403,0.925,"KIT, CHUK, PPARD, AKT1, ARAF, IKBKG, MAP2K1, MTOR, RELA, LEF1, JUP, HRAS, AKT2, NRAS, PML, SOS1, PIK3R1, SOS2, PIM1, TCF7, TCF7L2",0.235077015350112,0.0338582672609674,FALSE +"HCC15","Input","KEGG_ADHERENS_JUNCTION",-0.23557,-0.906,0.552,18295,1,"PTPRF, CTNNB1, CSNK2A1, SNAI2, WASF3, TGFBR1, ACTN1, NECTIN3, EP300, INSR, FYN",0.258060922270801,0,FALSE +"HCC15","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.45547,1.42,0.0835,4975,0.378,"PRKAB1, TNFRSF1B, POMC, CHUK, PRKAA2, SLC2A1, MAPK8, TRAF2, PPARA, ADIPOR1, PRKCQ, AKT1, G6PC2, IKBKG, NFKBIA, IRS1, TNFRSF1A, MTOR, RELA, CPT1A, LEPR, MAPK9, AKT2, NFKBIB, ADIPOR2, RXRA, PRKAA1, ACACB",1.0783135245164,0.422508200162775,FALSE +"HCC15","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.21768,-0.8,0.716,17925,0.992,"IL4I1, GFPT2, ABAT, GLUL",0.145086977692144,0.00348832784582135,FALSE +"HCC15","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.21922,0.692,0.918,1535,0.999,"PDPK1, INS, ATP1B1, SGK1, FXYD4",0.0371573187987575,0.000434511774017692,FALSE +"HCC15","Input","KEGG_ALLOGRAFT_REJECTION",-0.21117,-0.796,0.766,4032,0.968,"FAS, CD40, IL10, GZMB, IL5, IFNG, FASLG, PRF1, CD40LG, IL2, CD28, CD80, IL4, CD86, TNF, IL12B, IL12A",0.115771230367396,0.0141246426916063,FALSE +"HCC15","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.68384,2.17,0,1,0.115,"PLA2G1B",Inf,0.939302159646388,TRUE +"HCC15","Input","KEGG_ALZHEIMERS_DISEASE",0.24113,0.765,0.809,4667,1,"NDUFS3, IDE, ITPR1, CASP9, CALM3, CHP1, APAF1, CALM1, CASP7, ATP5F1B, CAPN1, NDUFA9, NAE1, ATP2A2, NDUFV3, CASP8, COX5A, ITPR3, TNFRSF1A, NDUFB10, ATP5PO, NDUFA2, PPP3R1, COX7A2, NDUFB1, GAPDH, ATP5F1C, NDUFS1, PSEN2, BID, NDUFAB1, CAPN2, ATP5MC3, ATP5F1D, ADAM17, COX8A, FAS, ATF6, NCSTN, CALML6, ATP5MC2, CYC1, COX4I1, SDHD",0.0920514783877277,0,FALSE +"HCC15","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.49543,1.57,0.0308,3522,0.321,"IARS2, EARS2, PSTK, FARSB, SEPSECS, RARS2, MTFMT, SARS2, YARS2",1.51144928349956,0.493494967595128,FALSE +"HCC15","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.34327,1.08,0.328,5776,0.716,"GNPNAT1, UGDH, PGM3, GNPDA2, PMM2, GALK2, GPI, GFPT1, GALE, FPGT, HK3, NANS, GMDS, HK1, HEXB, PGM2, UXS1, PGM1, CMAS, HEXA",0.484126156288321,0.145086977692144,FALSE +"HCC15","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.41376,1.29,0.144,3725,0.428,"TNFRSF1B, TOMM40, CASP9, CHP1, APAF1, SOD1, MAPK14, BCL2L1, MAP2K6, MAPK13, TNFRSF1A, MAP3K5, PPP3R1, BID",0.84163750790475,0.368556230986828,FALSE +"HCC15","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.18466,0.588,0.974,6720,1,"NFYC, PSME2, B2M, CTSL, KLRC3, HSP90AA1, LGMN, HSP90AB1, KLRC2, PSME1, HSPA2, HSPA1A, HSPA8, PDIA3, CANX, IFI30, NFYA, HSPA5, HSPA4",0.0114410431213845,0,FALSE +"HCC15","Input","KEGG_APOPTOSIS",0.43088,1.35,0.108,4034,0.376,"CHUK, IL3RA, CASP9, IRAK3, CHP1, APAF1, IRAK4, TRAF2, IRAK2, CASP7, ATM, AKT1, BCL2L1, CAPN1, IKBKG, NFKBIA, TNFRSF10A, MAP3K14, CASP8, CASP10, PRKACB, TNFRSF1A, RELA, PPP3R1, RIPK1, BID, CAPN2, AKT2, ENDOD1, FAS, PRKAR2A",0.96657624451305,0.424812155072339,FALSE +"HCC15","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.53006,1.69,0.0151,1901,0.245,"PLA2G1B, LTA4H, CYP4F3, GGT5, PTGES, AKR1C3, PLA2G4A, GPX4, CBR1, GGT1",1.82102305270683,0.610833915635468,TRUE +"HCC15","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.31591,0.994,0.44,4880,0.85,"CPS1, AZIN2, SAT1, ALDH9A1, SRM, GLUD1, GAMT, ALDH3A2, ARG2, ALDH2, GOT2, MAOA, ODC1, AGMAT, CKB, OAT, ALDH18A1, ALDH7A1, ALDH4A1",0.356547323513813,0.0705810742857073,FALSE +"HCC15","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.22285,-0.826,0.667,15744,1,"CACNA1C, ACTN2, CACNA2D2, LAMA2, CACNA2D3, ITGA7, RYR2, CACNB4, CACNA1D, CACNG4, ITGA4, SLC8A1, ITGB3, DMD, CACNA2D1, CTNNB1, ACTN1, ITGB8, CACNB1, CACNB3",0.175874166083451,0,FALSE +"HCC15","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.41692,1.32,0.126,3177,0.402,"UGDH, ALDH9A1, ALDH3A2, ALDH2",0.899629454882437,0.39577394691553,FALSE +"HCC15","Input","KEGG_ASTHMA",-0.18282,-0.671,0.924,3491,0.95,"IL13, CD40, FCER1A, IL10, IL5, IL9, MS4A2, CD40LG, IL3, FCER1G, CCL11, IL4, PRG2, RNASE3, TNF, EPX",0.0343280287798933,0.0222763947111523,FALSE +"HCC15","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.25945,0.805,0.763,14161,1,"FAS, CD40, IL10, GZMB, TPO, IL5, CTLA4, IFNA4, IFNA17, IFNA6, IFNA16, FASLG, IFNA10, IFNA2, IFNA7, PRF1, IFNA14, CD40LG, IL2, CD28, TSHB, IFNA1, CD80, IFNA13, IL4, CGA, IFNA21, TG, IFNA8, IFNA5, TSHR, CD86",0.11747546204512,0,FALSE +"HCC15","Input","KEGG_AXON_GUIDANCE",-0.33687,-1.22,0.168,15481,0.905,"EPHA7, FES, UNC5A, EPHA6, PAK3, SEMA3G, EFNA4, ROBO2, CXCL12, DPYSL5, EPHA3, EPHA4, EPHA5, DPYSL2, PAK2, EPHB2, EPHA1, SEMA6D, NTNG1, EPHB1, SRGAP1, PLXNC1, CXCR4, SEMA3D, SEMA3E, NFATC2, SEMA5A, SEMA6C, SLIT2, SEMA6A, SEMA4A, NTN1, EFNB3, PLXNB2, EFNB1, PLXNA2, UNC5B, EFNA3, PLXNB3, SEMA3A, SRGAP3, LIMK2, NFATC1, SEMA7A, L1CAM, ROBO1, FYN, ROBO3, PLXNB1, GSK3B",0.774690718274137,0.0433514207947967,FALSE +"HCC15","Input","KEGG_BASAL_CELL_CARCINOMA",-0.18834,-0.671,0.892,15472,0.95,"WNT2B, WNT7A, PTCH2, APC2, HHIP, GLI1, DVL2, WNT10A, WNT10B, WNT5A, DVL3, FZD8, WNT7B, CTNNB1, GSK3B",0.0496351456238769,0.0222763947111523,FALSE +"HCC15","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.46988,1.47,0.0573,2124,0.36,"TAF1L, GTF2H1, GTF2A1, TAF12, TAF9, TBPL1, GTF2H3, TBP, GTF2IRD1",1.24184537803261,0.443697499232713,FALSE +"HCC15","Input","KEGG_BASE_EXCISION_REPAIR",0.35265,1.1,0.28,6586,0.715,"POLE2, TDG, POLE3, PARP4, POLD3, OGG1, LIG1, FEN1, POLD1, UNG, NEIL1, POLL, POLE4, LIG3, NEIL3, APEX2, NTHL1",0.552841968657781,0.145693958198919,FALSE +"HCC15","Input","KEGG_BETA_ALANINE_METABOLISM",0.3441,1.08,0.31,4736,0.716,"HADHA, ALDH9A1, HIBCH, SRM, ALDH3A2, ALDH2, ECHS1, GAD1, ALDH7A1",0.508638306165727,0.145086977692144,FALSE +"HCC15","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29902,0.946,0.534,4664,0.88,"HADHA, HACD1, ACOT7, ACOX1, PECR, YOD1, FADS1",0.272458742971444,0.0555173278498314,FALSE +"HCC15","Input","KEGG_BLADDER_CANCER",-0.30586,-1.15,0.25,15843,0.84,"RAF1, MMP9, VEGFA, ERBB2, FGFR3, CDKN1A, DAPK2, MMP1, MAP2K2, VEGFB, PGF, MMP2, CDKN2A, DAPK3, DAPK1, RB1",0.602059991327962,0.0757207139381184,FALSE +"HCC15","Input","KEGG_BUTANOATE_METABOLISM",0.35252,1.09,0.309,4736,0.72,"HADHA, ALDH9A1, ALDH3A2, ACAT1, AACS, ALDH2, ACADS, ALDH5A1, L2HGDH, ECHS1, GAD1, ACSM4, ALDH7A1",0.510041520575165,0.142667503568732,FALSE +"HCC15","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.2376,0.743,0.844,4450,1,"NFAT5, CHUK, SYK, IFITM1, CHP1, LYN, AKT1, NFATC3, IKBKG, NFKBIA, MAP2K1, RELA, CD22, PPP3R1, HRAS, AKT2, NRAS, PTPN6, NFKBIB, SOS1",0.073657553374345,0,FALSE +"HCC15","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.16516,0.519,0.99,3531,1,"NTSR1, ITPR1, GNAL, CALM3, VDAC2, CHP1, ADCY9, ADCY7, CALM1, GNA15, P2RX5, MYLK2, PLCD4, PHKB, ATP2A2, PHKA1, PRKACB, ITPR3, PTK2B, PPP3R1, VDAC1, ITPKA, ITPKB",0.00436480540245009,0,FALSE +"HCC15","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.36529,-1.31,0.14,14113,1,"COX7B2, ATP1B2, MYL2, TPM4, ATP1A2, UQCR11, FXYD2, TNNC1, UQCRHL, COX8C, CACNG7, CACNA1C, TNNT2, CACNA2D2, CACNA2D3, RYR2, CACNB4, COX6B2, UQCRC1, CACNA1D, CACNG4, COX5B, UQCR10, COX6C, SLC8A1, TPM1, ATP1A3, COX7C, UQCRB, CACNA2D1, TPM2, CACNB1, CACNB3",0.853871964321762,0,FALSE +"HCC15","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.25305,-0.942,0.485,15177,1,"VCAM1, CDH4, CLDN10, ITGA9, CDH3, CLDN16, NLGN4X, CNTNAP2, CLDN11, JAM2, NCAM2, NLGN3, CNTN1, ITGAM, NRXN2, JAM3, CD8A, CLDN22, SELL, PDCD1LG2, CADM1, NCAM1, NRXN3, NFASC, NLGN1, NECTIN1, ITGA4, NRCAM, ICOSLG, SDC2, PTPRF, NEO1, NECTIN3, ITGB8, L1CAM, SDC1",0.314258261397736,0,FALSE +"HCC15","Input","KEGG_CELL_CYCLE",0.455,1.45,0.0643,5635,0.352,"PTTG1, CCND3, CDC25C, CDC23, ORC1, TTK, PLK1, BUB3, ANAPC4, SMAD2, BUB1, CCNB1, ORC4, ORC3, PTTG2, CCNB2, MCM6, ANAPC5, PRKDC, CHEK1, SKP1, CDC6, ATM, E2F3, ABL1, MCM3, CDC7, SMC3, YWHAQ, CDK1, BUB1B, MCM4, HDAC1, CDC45, CDC20, SMC1A, ORC2, YWHAG, E2F2, CDC25B, ANAPC7, ESPL1, ORC6, E2F4, SFN, CDC27, CCNE2, CDK2, TGFB1, CDC14A, DBF4, CDC14B, CDK6, YWHAZ, CCNH, CDKN2C, CUL1, CCNA2, ANAPC2, RBL1, MCM7, WEE2, MAD2L2, CDK7, CDKN1C, ORC5, HDAC2, STAG2, CDKN1B, WEE1, RAD21",1.19178902707578,0.453457336521869,FALSE +"HCC15","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.20526,0.654,0.924,5017,1,"CCL5, CHUK, SHC1, ROCK2, SHC3, GNG11, GNB5, ADCY9, ADCY7, WASL, ARRB1, GSK3A, LYN, AKT1, IKBKG, NFKBIA, CCL28, MAP2K1, CDC42, CCL22, PRKACB, PTK2B, CXCL5, CCL2, RELA, HRAS, GNAI1, PXN, CXCL8, GNB1, GRK5, AKT2, GNAI3, NRAS, NFKBIB, SOS1, CCL14, PIK3R1, STAT2, GNG10, SOS2, RAP1B",0.0343280287798933,0,FALSE +"HCC15","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.26224,0.822,0.726,5826,1,"CHUK, SHC1, SHC3, E2F3, ABL1, AKT1, ARAF, HDAC1, BCL2L1, CTBP2, IKBKG, NFKBIA, MAP2K1, CBL, E2F2, RELA, HRAS, AKT2, NRAS, TGFB1, TGFBR2, SOS1, CDK6, PIK3R1, SOS2, HDAC2, CRK, CDKN1B, MAPK3, TGFB2",0.139063379299906,0,FALSE +"HCC15","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.33336,1.04,0.374,6488,0.783,"NPAS2, CSNK1E, ARNTL, PER2, NR1D1, PER1, CRY2",0.42712839779952,0.106238237942057,FALSE +"HCC15","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.2438,0.763,0.815,1292,1,"PC, DLAT, IDH3A",0.0888423912600234,0,FALSE +"HCC15","Input","KEGG_COLORECTAL_CANCER",0.22631,0.714,0.877,5403,0.988,"CASP9, SMAD2, AXIN2, MAPK8, MSH2, AKT1, ARAF, APC, MAP2K1, MSH3, MSH6, APPL1, LEF1, MAPK9, AKT2, TGFB1, TGFBR2, PIK3R1, BIRC5, TCF7, TCF7L2",0.0570004066339595,0.00524305541237188,FALSE +"HCC15","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.3153,0.992,0.455,3883,0.845,"THBD, SERPIND1, C3AR1, CFH, CD46, TFPI, PLAUR, MASP2, F13A1, C5, PLAU, SERPINC1, CD59, CFD",0.341988603342888,0.0731432910503077,FALSE +"HCC15","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.46262,1.45,0.0708,3195,0.352,"BHMT, ADI1, MAT2A, MAT2B, TRDMT1, LDHA, SRM, AHCYL2, AHCYL1, APIP, GOT2",1.14996674231023,0.453457336521869,FALSE +"HCC15","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.17804,0.561,0.981,672,1,"TNFSF15, TNFRSF1B, CSF2RA, CCL5, EGF, TNFSF8, KIT, FLT4, CNTF, IL3RA, IFNGR1",0.0083309926200515,0,FALSE +"HCC15","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.34791,1.1,0.317,4369,0.715,"CCL5, CHUK, TBK1, IKBKG, POLR3K, NFKBIA, POLR3A, RELA, ZBP1, RIPK1, RIPK3, ADAR, POLR3B, POLR1C, NFKBIB, IL18",0.498940737782249,0.145693958198919,FALSE +"HCC15","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.22816,-0.869,0.601,14773,1,"SGCD, TNF, TNNC1, DES, CACNG7, ITGA9, ADCY1, CACNA1C, TNNT2, CACNA2D2, LAMA2, CACNA2D3, ADCY5, ITGA7, RYR2, CACNB4, CACNA1D, CACNG4, ITGA4, SLC8A1, ITGB3, TPM1, DMD, CACNA2D1, ITGB8, GNAS, TPM2, CACNB1, CACNB3",0.22112552799726,0,FALSE +"HCC15","Input","KEGG_DNA_REPLICATION",0.60201,1.9,0.00238,4243,0.207,"DNA2, MCM6, POLE2, RFC5, POLE3, MCM3, MCM4, POLA1, RFC2, PRIM1, POLA2, PRIM2, POLD3, RFC1, RPA2, RNASEH1, RPA1, LIG1, FEN1, POLD1",2.62342304294349,0.684029654543082,TRUE +"HCC15","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.15222,-0.578,0.971,16707,0.985,"ETV7, FMN2, NOTCH4, CPEB1",0.0127807700919951,0.00656376950238827,FALSE +"HCC15","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.15554,0.49,0.996,3621,0.997,"ALDH3A1, ALDH3B1, GSTM2, GSTM4, GSTM3, CYP3A5, MAOA, MGST1",0.00174066157630127,0.00130484168834428,FALSE +"HCC15","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.30544,-1.2,0.191,17562,0.865,"ITPA, XDH, UMPS, GMPS, NAT1, IMPDH2, UCKL1",0.718966632752272,0.0629838925351858,FALSE +"HCC15","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.2005,-0.752,0.839,15298,0.966,"COL11A1, LAMC1, ITGA9, RELN, COL5A3, COL6A1, LAMA2, COL6A3, THBS2, ITGA7, CHAD, COL1A2, COL4A2, FN1, THBS4, ITGA4, LAMA4, ITGB3, COL6A2, SV2A, SDC2, THBS3, LAMB1, ITGB8, SDC1, CD47",0.0762380391712997,0.0150228735845067,FALSE +"HCC15","Input","KEGG_ENDOCYTOSIS",0.27333,0.866,0.683,4500,0.971,"DNM3, EGF, STAM, AP2S1, KIT, IQSEC2, RAB11FIP2, RAB11A, USP8, ARRB1, STAM2, SH3KBP1, SMAP1, AP2A2, VTA1, SMURF2, SMAP2, NEDD4, TSG101, GIT2, ASAP1, CBL, PIKFYVE, EEA1, CDC42, STAMBP, RUFY1, ACAP3, CHMP4C, VPS4A, ARAP2, ASAP2, CHMP4A, SH3GLB2, LDLRAP1, VPS37A, WWP1, DNAJC6, SH3GLB1, HRAS, CLTCL1, GRK5, CHMP1B, DNM1L, AP2B1, DNM1, ARFGAP2, RAB31, IGF1R, CLTB, RAB11FIP3",0.165579296318467,0.0127807700919951,FALSE +"HCC15","Input","KEGG_ENDOMETRIAL_CANCER",0.29474,0.946,0.515,5551,0.88,"EGF, PDPK1, CASP9, AXIN2, AKT1, CTNNA1, ARAF, APC, MAP2K1, LEF1, HRAS, AKT2, ILK, NRAS, SOS1, PIK3R1, ELK1, SOS2, TCF7, PTEN, TCF7L2, CDH1",0.288192770958809,0.0555173278498314,FALSE +"HCC15","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.44259,1.39,0.0896,4447,0.396,"CCL5, ATP6V0A4, CHUK, MAPK8, TJP1, LYN, MAPK14, ATP6V0E1, ATP6V1E1, ATP6V1C1, ATP6V0A1, ATP6V1H, IKBKG, ATP6V0B, NFKBIA, TCIRG1, ATP6V0D1, CDC42, MAP3K14, ATP6V0C, MAPK13, MAP2K4, RELA, ATP6V1A, ATP6V0E2, CXCL8, MAPK9, ADAM17, HBEGF, ATP6V1G1, ATP6V0A2",1.04769199033787,0.402304814074488,FALSE +"HCC15","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.19345,-0.747,0.784,17973,0.946,"SHC2, MAPK10, EIF4EBP1, PIK3CD, MAP2K7, AKT3, PLCG1, PIK3R2, JUN, GSK3B, GAB1",0.105683937315562,0.0241088635982073,FALSE +"HCC15","Input","KEGG_ETHER_LIPID_METABOLISM",0.60914,1.93,0.00354,2363,0.227,"PLA2G1B, PAFAH2, PAFAH1B2, PAFAH1B3, PLA2G4A, PLPP3, CHPT1",2.45099673797421,0.643974142806877,TRUE +"HCC15","Input","KEGG_FATTY_ACID_METABOLISM",0.35784,1.12,0.294,3417,0.695,"HADHA, ECI1, HADHB, ACADSB, ALDH9A1, ALDH3A2, ACOX1, ACAT1, ALDH2, CPT1A, ACADS",0.531652669587843,0.158015195409886,FALSE +"HCC15","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.34356,1.07,0.334,3845,0.722,"PLA2G1B, SYK, PDPK1, MAPK8, LYN, MAPK14, AKT1, PLA2G4A, PRKCE, MAP2K1, MAP2K6, MAPK13, MAP2K4, IL13, HRAS, MAPK9, AKT2",0.476253533188435,0.141462802430361,FALSE +"HCC15","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.26261,0.832,0.72,4238,1,"DNM3, SYK, CFL2, ARPC2, WASL, ARPC5L, LYN, AKT1, PLA2G4A, WASF2, PLPP3, PRKCE, ARPC3, ASAP1, MAP2K1, PIKFYVE, CDC42, ASAP2, CFL1, MYO10, DNM1L, AKT2, LIMK1, DNM1, ARPC4",0.142667503568732,0,FALSE +"HCC15","Input","KEGG_FOCAL_ADHESION",0.18106,0.574,0.988,5638,1,"COL4A6, ITGA10, EGF, CCND3, FLT4, PDPK1, FLNB, SHC1, ROCK2, ITGA1, SHC3, COL3A1, MAPK8, DIAPH1, COL5A2, MYLK2, AKT1, ITGB5, MAP2K1, PARVA, CDC42, ARHGAP35, ITGB7, PPP1CC, COL4A4, ITGB4, ACTN4, ITGA2, HRAS, ARHGAP5, LAMB3, PXN, CAPN2, MAPK9, AKT2, ILK, PPP1CA, IGF1R, PPP1CB, SOS1, XIAP, ITGA6, ITGB1, PIK3R1, ELK1, SOS2, RAP1B, PTEN, BIRC2, LAMA1, RAPGEF1, PAK1, PRKCA, ITGA11, CRK, VCL, BIRC3, LAMB2, BCAR1",0.00524305541237188,0,FALSE +"HCC15","Input","KEGG_FOLATE_BIOSYNTHESIS",0.49637,1.54,0.0457,4914,0.336,"PTS, SPR, DHFR, GCH1, GGH, FPGS",1.34008379993015,0.473660722610156,FALSE +"HCC15","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.27561,0.879,0.642,6028,0.968,"PFKP, PMM2, MTMR2, ALDOA, FPGT, SORD, HK3, GMDS, HK1, KHK, MTMR7, MTMR6, PHPT1",0.192464971931147,0.0141246426916063,FALSE +"HCC15","Input","KEGG_GALACTOSE_METABOLISM",0.35175,1.11,0.296,3599,0.711,"GLA, PFKP, B4GALT1, G6PC2, GALK2, GALE, HK3",0.528708288941061,0.148130399270234,FALSE +"HCC15","Input","KEGG_GAP_JUNCTION",0.23255,0.729,0.843,5227,1,"TUBAL3, EGF, ITPR1, ADCY9, ADCY7, MAP3K2, TJP1, CDK1, LPAR1, MAP2K1, PRKACB, ITPR3, TUBB3, HRAS, GNAI1, GNAI3, NRAS, SOS1, TUBB2A, SOS2, TUBA1C, TUBB, TUBA4A, TUBA1B",0.0741724253752577,0,FALSE +"HCC15","Input","KEGG_GLIOMA",0.23961,0.755,0.823,4999,1,"EGF, SHC1, SHC3, CALM3, CALM1, E2F3, AKT1, ARAF, TGFA, MAP2K1, E2F2, MTOR, HRAS, AKT2, NRAS, IGF1R, SOS1, CALML6, CDK6, PIK3R1, CALM2, SOS2",0.0846001647877302,0,FALSE +"HCC15","Input","KEGG_GLUTATHIONE_METABOLISM",0.5227,1.68,0.0151,4965,0.22,"GCLC, PGD, GSR, GCLM, G6PD, GGT5, RRM1, TXNDC12, GPX4, SRM, GGT1, GSTM2, GSTM4, GSS, GSTM3, RRM2, ODC1, GPX7, MGST1, GPX3, MGST2, GSTO1, GSTK1, RRM2B",1.82102305270683,0.657577319177794,TRUE +"HCC15","Input","KEGG_GLYCEROLIPID_METABOLISM",0.35194,1.09,0.312,3355,0.72,"GLA, AGPAT3, DGKG, AKR1A1, ALDH9A1, PLPP3, GPAT3, ALDH3A2, DGKD, MBOAT1, ALDH2, TKFC",0.505845405981557,0.142667503568732,FALSE +"HCC15","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.43918,1.37,0.0898,2870,0.36,"PLA2G1B, AGPAT3, PTDSS2, DGKG, PTDSS1, GPD2, LYPLA2, MBOAT7, PLA2G4A, ETNK1, PLPP3, GPAT3, LYPLA1, CHPT1, DGKD, GNPAT, MBOAT1",1.0467236633327,0.443697499232713,FALSE +"HCC15","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.25618,0.812,0.734,3612,1,"BHMT, DMGDH, GAMT, SHMT1, MAOA, DLD",0.134303940083929,0,FALSE +"HCC15","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.39976,1.26,0.175,4179,0.468,"ALDH3A1, ENO3, ENO1, PFKP, DLAT, AKR1A1, ALDH3B1, ALDH9A1, G6PC2, LDHA, ALDH3A2, GPI, PGAM1, GALM, PKM, ALDOA, ALDH2, GAPDH, HK3, DLD, ACSS2, LDHAL6B",0.756961951313706,0.329754146925876,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.29443,0.919,0.559,4809,0.924,"CHST15, CSGALNACT1, B3GAT3, DSE, CSGALNACT2, B3GAT2, CHST7",0.252588192113577,0.0343280287798933,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.27858,-1.03,0.359,15306,0.932,"HS3ST5, NDST3, B3GAT1, HS3ST3B1, B4GALT7, HS3ST1, HS3ST3A1, NDST1, XYLT1, HS6ST2, XYLT2, EXT1",0.444905551421681,0.0305840876460186,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.45621,-1.74,0.0288,17191,1,"B3GNT7, CHST2, FUT8, ST3GAL1, B3GNT2, B4GALT4, B4GALT2",1.54060751224077,0,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.44304,1.4,0.0805,6089,0.391,"HYAL1, GUSB, GALNS, GNS, ARSB, HGSNAT, NAGLU, HEXB, SGSH, HEXA, HYAL3",1.09420411963213,0.407823242604133,FALSE +"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.27762,-1.06,0.333,14743,0.907,"GLB1, B3GALT4, ST6GALNAC6, ST8SIA1, ST6GALNAC5, ST3GAL1, SLC33A1",0.47755576649368,0.0423927129399047,FALSE +"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.3276,1.02,0.426,71,0.818,"GLA",0.370590400897281,0.087246696328677,FALSE +"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.32609,-1.24,0.152,16056,0.956,"B3GALT1, ABO, B3GALT5, FUT3, ST8SIA1, B3GNT2, ST3GAL6, B4GALT4, B4GALT2",0.818156412055227,0.0195421077238999,FALSE +"HCC15","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.3429,1.08,0.327,2640,0.716,"PIGN, PIGB, DPM2, PGAP1, PIGP, PIGU",0.485452247339714,0.145086977692144,FALSE +"HCC15","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.27868,0.873,0.66,2851,0.963,"PGP, CS",0.180456064458131,0.0163737128754655,FALSE +"HCC15","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.33809,1.07,0.323,3080,0.722,"PLA2G1B, ITPR1, CALM3, ADCY9, ADCY7, CALM1, MAPK8, MAP3K2, MAPK14, PLA2G4A, MAP2K1, CDC42, MAP2K6, PRKACB, MAPK13, ITPR3, PTK2B, MAP2K4",0.490797477668897,0.141462802430361,FALSE +"HCC15","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.23138,-0.866,0.65,9778,1,"IFNG, FASLG, PRF1, KIR2DL1, KIR3DL2, IL2, KLRD1, CD28, KIR3DL1, KIR2DL3, CD80, KLRC1, CD86, IL6, TNF, IL1B",0.187086643357144,0,FALSE +"HCC15","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.19735,0.616,0.956,2636,1,"BTRC, CSNK1E, BMP4, CSNK1G1, GLI2, CSNK1G2, WNT3, PRKACB",0.0195421077238999,0,FALSE +"HCC15","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.2343,0.736,0.846,675,1,"CD14, CSF2RA, KIT, IL3RA, ITGA1",0.0726296369609765,0,FALSE +"HCC15","Input","KEGG_HISTIDINE_METABOLISM",0.4684,1.46,0.0617,5111,0.361,"AMDHD1, ALDH3A1, TRMT11, ALDH3B1, ALDH9A1, HAL, ALDH3A2, METTL2B, ALDH2, MAOA, BUD23, ALDH7A1, HDC, LCMT2, LCMT1",1.20971483596676,0.442492798094342,FALSE +"HCC15","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.43939,1.37,0.0995,5951,0.36,"XRCC3, RAD51, BLM, MRE11, RAD54B, POLD3, RPA2, MUS81, RAD54L, RPA1, NBN, XRCC2, POLD1, RAD50, RAD51D, RPA3, RPA4, TOP3A, EME1, RAD52",1.00217691925427,0.443697499232713,FALSE +"HCC15","Input","KEGG_HUNTINGTONS_DISEASE",0.26277,0.824,0.711,4667,1,"NDUFS3, RCOR1, AP2S1, POLR2J2, ITPR1, BDNF, CASP9, VDAC2, APAF1, SOD1, TGM2, ATP5F1B, AP2A2, POLR2E, TBPL1, HDAC1, DCTN4, TBP, SP1, NDUFA9, POLR2D, POLR2A, NDUFV3, CASP8, POLR2C, CREB3L2, COX5A, NDUFB10, ATP5PO, POLR2L, NDUFA2, VDAC1, COX7A2, NDUFB1, ATP5F1C, CLTCL1, NDUFS1, NDUFAB1, POLR2G, ATP5MC3, DNAH1, TFAM, ATP5F1D, COX8A, SIN3A, AP2B1, CLTB, ATP5MC2, CYC1, COX4I1, SDHD",0.148130399270234,0,FALSE +"HCC15","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.21991,-0.841,0.669,14165,1,"MYL2, SGCG, TPM4, PRKAG1, IGF1, IL6, SGCD, TNF, TNNC1, DES, CACNG7, PRKAG2, ITGA9, CACNA1C, ACE, TNNT2, CACNA2D2, LAMA2, CACNA2D3, ITGA7, RYR2, CACNB4, CACNA1D, CACNG4, ITGA4, SLC8A1, ITGB3, TPM1, DMD, CACNA2D1, ITGB8, TPM2, CACNB1, CACNB3",0.174573882232177,0,FALSE +"HCC15","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.23102,-0.863,0.62,17903,0.986,"PIP5K1C, PIK3C3, PLCE1, PIK3CD, ALDH6A1, INPP5J, PLCG1, PLCB1, INPP4B",0.207608310501746,0.0061230850587888,FALSE +"HCC15","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.2936,0.913,0.572,4999,0.93,"PRKAB1, PDE3A, PPP1R3C, PRKAA2, PDPK1, MKNK2, SHC1, INS, SHC3, CALM3, CALM1, MAPK8, MKNK1, AKT1, ARAF, G6PC2, PHKB, MAP2K1, CBL, PHKA1, PRKACB, PPP1CC, IRS1, MTOR, SORBS1, ACACA, HRAS, HK3, MAPK9, AKT2, PRKAR2A, SOCS4, PPP1CA, NRAS, PPP1CB, SOS1, PHKG2, CALML6, HK1, TSC1, PIK3R1, PRKAA1, CALM2, ELK1, ACACB, SOS2",0.242603971206976,0.0315170514460649,FALSE +"HCC15","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.19757,-0.725,0.89,17241,0.956,"CXCR4, ITGA4, CCR10, ICOSLG, IL15",0.0506099933550872,0.0195421077238999,FALSE +"HCC15","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.17092,0.532,0.998,5338,1,"CSF2RA, CCND3, STAM, CNTF, IL3RA, IFNGR1, STAM2, AKT1, SPRED2, BCL2L1, SPRED1, IL10RB, CBL, IL22RA1, SPRY4, PIAS1, IFNLR1, LEPR, IL13, AKT2, SOCS4, PTPN6, IL13RA1, IFNAR1, SPRY1, SOS1, PIK3R1, STAT2, OSMR, SOS2, PIM1, MPL, IFNAR2, IL4R, IL20RA",0.000869458712628891,0,FALSE +"HCC15","Input","KEGG_LEISHMANIA_INFECTION",0.18164,0.573,0.986,6037,1,"IFNGR1, IRAK4, MAPK14, NFKBIA, MAPK13, PTGS2, RELA, MAP3K7, TGFB1, PTPN6, NFKBIB, ITGB2, ITGB1, ELK1, TAB2, TRAF6, CYBA, MAPK3, TGFB2, IL10",0.0061230850587888,0,FALSE +"HCC15","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.20078,0.634,0.954,5638,1,"CLDN2, TXK, ROCK2, RASSF5, MAPK14, CTNNA1, SIPA1, CD99, CDC42, ARHGAP35, MAPK13, PTK2B, CLDN4, ACTN4, ARHGAP5, CTNND1, GNAI1, PXN, CLDN23, MSN, GNAI3, NOX1, ITGB2, ITGB1, PIK3R1, CLDN3, ESAM, CLDN20, RAP1B, EZR, PRKCA, ICAM1, CYBA, VCL, BCAR1",0.0204516252959049,0,FALSE +"HCC15","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.57214,1.81,0.00941,4736,0.243,"HADHA, ALDH9A1, ALDH3A2, ALDH2, ECHS1, YOD1, ALDH7A1",2.02641037657274,0.614393726401688,TRUE +"HCC15","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.59268,1.87,0.00595,1,0.2,"PLA2G1B",2.22548303427145,0.698970004336019,TRUE +"HCC15","Input","KEGG_LONG_TERM_DEPRESSION",0.41246,1.3,0.139,1786,0.419,"PLA2G1B, PPP2R1B, ITPR1, GNA13, PPP2R1A, LYN, ARAF, PLA2G4A",0.856985199745905,0.377785977033705,FALSE +"HCC15","Input","KEGG_LONG_TERM_POTENTIATION",0.22951,0.721,0.856,6597,1,"ITPR1, CALM3, CHP1, CALM1, ARAF, MAP2K1, PRKACB, PPP1CC, ITPR3, PPP3R1, HRAS, RPS6KA1, PPP1CA, NRAS, PPP1CB, CALML6, CALM2, RAP1B, PPP3CB, PRKCA, MAPK3, RAP1A, PPP1R12A, RPS6KA3, PLCB3, PPP3CC, GRIN1",0.0675262353228468,0,FALSE +"HCC15","Input","KEGG_LYSINE_DEGRADATION",0.43876,1.38,0.104,4736,0.382,"HADHA, KMT5A, SUV39H1, AASDHPPT, ALDH9A1, EHMT1, ALDH3A2, SETD1B, ACAT1, ALDH2, SETD1A, TMLHE, PLOD1, ECHS1, SUV39H2, SETD7, EHMT2, ASH1L, NSD1, ALDH7A1",0.98296666070122,0.417936637088291,FALSE +"HCC15","Input","KEGG_LYSOSOME",0.40725,1.26,0.163,5776,0.468,"GLA, HYAL1, ATP6V0A4, AP1S3, AP4E1, AP3M1, AP3B1, AP4B1, FUCA1, ARSG, SLC11A2, CLN3, ACP2, CD164, SLC17A5, GUSB, ATP6V0A1, SORT1, SLC11A1, ATP6V1H, ATP6V0B, GALNS, TCIRG1, ATP6V0D1, AP1G1, ATP6V0C, MFSD8, GNS, NAGPA, ARSB, CTSL, CTSF, CLTCL1, HGSNAT, AP3S1, GM2A, GNPTAB, LGMN, GNPTG, ATP6V0A2, CLTB, PPT1, NAGLU, PPT2, SMPD1, HEXB, ABCA2, PLA2G15, IGF2R, CTSV, TPP1, SGSH, GBA, M6PR, HEXA",0.787812395596042,0.329754146925876,FALSE +"HCC15","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.23077,0.716,0.848,3405,1,"PLA2G1B, FGF9, FGF19, CD14, EGF, PPP5C, CHUK, FLNB, BDNF, RPS6KA5, MKNK2, CHP1, MEF2C, MAPK8, MAP3K2, MKNK1, TRAF2, ARRB1, DUSP4, MAPK14, AKT1, PLA2G4A, MAP4K3, MAP3K8, IKBKG, NR4A1, MAP2K1, CDC42, MAP3K14, MAP2K6, PRKACB, MAPK13, ATF2, TAOK2, MAPKAPK5, TNFRSF1A, MAP2K4, STK3, CDC25B, RELA, MAP3K5, PPP3R1",0.0716041477432862,0,FALSE +"HCC15","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.24869,-0.882,0.537,13942,1,"ONECUT1, HNF4A, HNF1A, BHLHA15, FOXA2, PDX1, GCK, HNF1B, NR5A2, HNF4G",0.270025714300444,0,FALSE +"HCC15","Input","KEGG_MELANOGENESIS",0.16347,0.522,0.995,5572,1,"POMC, KIT, CALM3, ADCY9, ADCY7, CALM1, FZD3, MAP2K1, WNT3, PRKACB, CREB3L2, LEF1, HRAS, DVL1, GNAI1, GNAI3, MC1R, NRAS, CALML6, FZD9, FZD6, EDN1, CALM2, TCF7, TCF7L2, PRKCA, FZD1",0.00217691925427455,0,FALSE +"HCC15","Input","KEGG_MELANOMA",-0.24001,-0.892,0.576,16661,1,"FGF11, PIK3CA, CDKN1A, FGF2, FGF22, FGF1, PDGFRB, MAP2K2, PDGFD, FGF13, FGF12, MITF, PIK3CD, CDKN2A, AKT3, PDGFC, PIK3R2, RB1",0.239577516576788,0,FALSE +"HCC15","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.36037,1.13,0.282,3651,0.702,"ALDH3A1, CYP2S1, EPHX1, AKR1C2, AKR1C1, AKR1C3, ALDH3B1, GSTM2, GSTM4, GSTM3, CYP3A5, MGST1, CYP1B1",0.549750891680639,0.153662887870195,FALSE +"HCC15","Input","KEGG_MISMATCH_REPAIR",0.55307,1.75,0.0151,5582,0.303,"MSH2, RFC5, RFC2, MSH3, POLD3, RFC1, MSH6, RPA2, RPA1, LIG1, POLD1, EXO1, RPA3, RPA4",1.82102305270683,0.518557371497695,FALSE +"HCC15","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.29786,0.93,0.553,1866,0.915,"MLST8, PRKAA2, PDPK1, CAB39, INS, AKT1, EIF4B, ULK3, RICTOR",0.257274868695302,0.0385789059335517,FALSE +"HCC15","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.32687,1.02,0.425,4493,0.818,"RAET1G, RAET1E, SH2D1B, NFAT5, ULBP3, SYK, SHC1, IFNGR1, SHC3, CHP1, ARAF, ICAM2, NFATC3, MAP2K1, TNFRSF10A, MICB, PTK2B, MICA, KLRC3, PPP3R1, HRAS, BID, FAS, KLRC2, NRAS, PTPN6, IFNAR1, SOS1, ITGB2",0.371611069949688,0.087246696328677,FALSE +"HCC15","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.2196,-0.81,0.667,11147,1,"OPRK1, GRIN2A, HTR2B, NPY2R, GABRG1, TAAR1, GRM6, MC2R, FSHR, CYSLTR2, HTR1E, CHRND, GABRA1, PRL, P2RY10, HTR4, GH1, GRM1, P2RX3, HTR1F, TSHB, ADRA1A, HCRTR2, GABRA4, NMUR1, GPR50, F2, CHRNG, RXFP1, MC5R, DRD5, MCHR1, GCGR, CHRM1, MC3R, HTR6, AVPR1A, CYSLTR1, GABRB2, GRIN3A, CALCR, GRM7, P2RX4, AVPR1B, TACR3, HRH3, ADCYAP1R1, HTR2A, GABRR2, GRIA1, CGA, NPY5R, GRM5, NMUR2, THRB, P2RY8, UTS2R, LHB, NPFFR1, CHRNB1, GRM3, NPY4R, HTR1B, GHSR, CHRNA4, PRSS2, P2RY13, GHRHR, GABRR1, GRIK3, CHRM2, F2RL3, GRIA4, CHRNA1, P2RX2, P2RX1, GABRD, PTGER3, GABRA5, PRSS1, MC4R, MCHR2, GRIA2, TACR2, CHRNA3, ADRA2C, GABRB1, P2RX6, GABRG3, TRHR, SCTR, CRHR1, CHRNB2, TSHR, PLG, GRID2, OPRD1, GRIA3, DRD1, CTSG, GRM2, GRM4, LPAR4, GRIN2C, TBXA2R, GABRA2, GABRG2, ADRA2A, GABRP, PTGIR, PTGER4, ADRA1D, NPBWR1, GRIN2B, CHRNA9, AGTR1, SSTR2, GRIN2D, CHRNB4, GRIK5, P2RY14, MLNR, MTNR1A, PTH2R, ADRA2B, GRM8, EDNRB, SSTR1, NPFFR2, NPY1R, CNR1, DRD2, PTAFR, DRD4, CHRNE, PTGER1, S1PR3, HTR2C, GALR3, GRID1, PRLR, NMBR, GABBR2, GRIK4, GPR83, GRPR, AVPR2, S1PR5, GPR35, GABRQ, PTGFR, PTGER2, PTH1R, OXTR, VIPR1, GHR, LPAR2, P2RX7, CHRM4, PRSS3, P2RY1, LPAR3, HRH4, GRIK2, BDKRB1, ADORA1, ADRA1B, BDKRB2, GABRA3, OPRL1, ADORA2A, ADORA2B, GLRB, S1PR2, GABBR1",0.175874166083451,0,FALSE +"HCC15","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.23263,0.737,0.86,5017,1,"PDPK1, BDNF, RPS6KA5, SHC1, SHC3, CALM3, IRAK3, IRAK4, CALM1, MAPK8, IRAK2, ABL1, MAPK14, PRDM4, AKT1, YWHAQ, SORT1, NFKBIA, KIDINS220, MAP2K1, CDC42, YWHAG, MAPK13, IRS1, RELA, MAP3K5, HRAS, MAPK9, AKT2, RPS6KA1, NRAS, NFKBIB, SOS1, CALML6, YWHAZ, ZNF274, PIK3R1, CALM2, SOS2, RAP1B",0.0655015487564323,0,FALSE +"HCC15","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.46767,1.48,0.0657,3025,0.358,"NMNAT1, NAMPT, NNMT, NADK, NT5C2, NT5M, NT5E, NMRK1, NNT",1.18243463044022,0.446116973356126,FALSE +"HCC15","Input","KEGG_NITROGEN_METABOLISM",0.28502,0.907,0.584,1956,0.926,"CA12, CPS1, HAL, GLUD1",0.233587152887601,0.0333890133180656,FALSE +"HCC15","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.31908,1,0.457,5819,0.854,"CCL5, CHUK, MAPK8, MAPK14, IKBKG, NFKBIA, CASP8, MAPK13, CCL2, RELA, MAP3K7, CXCL8, HSP90AA1, MAPK9, HSP90AB1, NFKBIB, IL18, XIAP, PYCARD, NOD1, ERBIN, TAB2, TAB3, BIRC2, CARD6, TRAF6, BIRC3, SUGT1, MAPK3",0.34008379993015,0.068542129310995,FALSE +"HCC15","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.53642,1.68,0.0211,4654,0.22,"XRCC5, NHEJ1, PRKDC, XRCC4, MRE11, DCLRE1C, FEN1, RAD50",1.67571754470231,0.657577319177794,TRUE +"HCC15","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.22852,0.717,0.875,4999,1,"EGF, PDPK1, CASP9, RASSF5, E2F3, AKT1, ARAF, TGFA, MAP2K1, E2F2, HRAS, AKT2, NRAS, SOS1, CDK6, PIK3R1, RXRA, SOS2",0.0579919469776868,0,FALSE +"HCC15","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.20514,-0.763,0.76,16674,0.974,"DTX1, DLL1, DVL2, SNW1, CTBP1, DVL3, APH1A, MFNG, NOTCH4, DTX4, EP300",0.119186407719209,0.0114410431213845,FALSE +"HCC15","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.54037,1.7,0.021,5582,0.28,"XPA, GTF2H1, ERCC3, POLE2, RFC5, POLE3, GTF2H3, RFC2, DDB2, DDB1, CUL4B, ERCC8, POLD3, RFC1, ERCC4, RPA2, RPA1, ERCC6, LIG1, POLD1, CCNH, GTF2H5, CDK7, RPA3, RPA4",1.67778070526608,0.552841968657781,FALSE +"HCC15","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.38251,1.2,0.196,5764,0.547,"ALG9, MGAT5, MGAT5B, DPAGT1, GANAB, ALG1, B4GALT1, DPM2, STT3A, ALG6, ALG13, MAN2A2, ALG8, DPM3, DOLPP1, ALG2, ALG10, TUSC3, MAN1A1, RFT1, MGAT4B, STT3B, DDOST, MGAT2",0.707743928643524,0.262012673666569,FALSE +"HCC15","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.28237,-1.09,0.329,8964,0.949,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR2AT4, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR2A42, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, ARRB2, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR51E2, OR9Q2, OR6C68, OR6C74, OR10C1, CLCA1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, CNGA3, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR5AK2, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, GUCA1C, OR2T33, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, OR56A3, OR10H2, OR10AD1, OR52B2, OR51M1, OR1B1, OR2L3, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5B21, OR5M11, OR8G5, OR13G1, GUCA1B, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR52D1, OR51I1, OR5P3, OR52N2, OR8S1, OR9A2, OR51Q1, CALML3, OR13D1, OR8D2, OR1J2, OR2S2, OR2A5, OR52H1, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, ADCY3, OR2T8, OR2C1, OR8G1, OR4F15, OR52B6, OR2A25, OR2D3, OR1Q1, OR10H1, PRKACA, OR8A1, CALML5, OR2B2, OR1K1, OR2J3, OR10A6, OR2A2, OR4F3, OR10A4, GUCY2D, OR51B4, CAMK2A, OR13A1, OR6B2, OR2A12, OR2D2, OR2AG1, OR10A3, OR2K2, OR7C1, OR13H1, OR10A2, OR2A14, OR13J1, OR4F16, CLCA2, OR2H2, OR4F17, CNGB1, OR2W3, OR6A2, OR56B4, OR5K2, OR1L8, OR2AE1, OR1J1, OR2L2, CNGA4, CAMK2B, PDE1C, PRKG1, OR2AG2, PRKG2, GRK3",0.482804102050026,0.0227337875727074,FALSE +"HCC15","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.47145,1.49,0.0557,3375,0.356,"ATIC, MTHFS, MTFMT, SHMT1, GART, DHFR",1.25414480482627,0.448550002027125,FALSE +"HCC15","Input","KEGG_OOCYTE_MEIOSIS",0.53585,1.69,0.0175,5147,0.245,"PPP2R1B, PTTG1, CDC25C, SLK, CDC23, ITPR1, INS, PLK1, CALM3, CHP1, ANAPC4, PPP2R5C, BUB1, CCNB1, BTRC, ADCY9, ADCY7, CALM1, PPP2R1A, PTTG2, CCNB2, ANAPC5, PPP2R5D, SKP1, SMC3, YWHAQ, CDK1, CDC20, FBXO5, MAP2K1, SMC1A, YWHAG, PRKACB, PPP1CC, PPP2R5A, ITPR3, PPP3R1, SGO1, ANAPC7, ESPL1, REC8, RPS6KA1, CDC27, PPP1CA, CCNE2, CDK2, IGF1R, PPP1CB, CALML6, YWHAZ, CUL1, ANAPC2, PPP2CB, CALM2, FBXW11, MAD2L2, PPP3CB",1.75696195131371,0.610833915635468,TRUE +"HCC15","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.32405,1,0.433,2279,0.854,"FUCA1, FUCA2, MAN2C1",0.363512103646635,0.068542129310995,FALSE +"HCC15","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.24662,0.775,0.781,4667,1,"NDUFS3, ATP6V0A4, ATP5F1B, ATP6V0E1, ATP6V1E1, ATP6V1C1, ATP6V0A1, ATP6V1H, NDUFA9, ATP6V0B, ATP5MG, TCIRG1, ATP6V0D1, NDUFV3, PPA1, ATP6V0C, COX5A, NDUFB10, ATP5PO, COX15, NDUFA2, ATP6V1A, COX7A2, NDUFB1, ATP6V0E2, ATP5F1C, NDUFS1, NDUFAB1, ATP5MC3, ATP5F1D, COX8A, ATP6V1G1, ATP6V0A2, ATP5MC2, CYC1, COX4I1, SDHD",0.1073489661227,0,FALSE +"HCC15","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.30754,-1.18,0.229,14442,0.833,"GALNT3, GALNTL6, ST6GALNAC1, GALNT15, GALNT9, GALNT13, GCNT4, GCNT1, GALNT16, GALNT14, ST3GAL1, GALNT18, GALNT7",0.640164517660112,0.0793549985932124,FALSE +"HCC15","Input","KEGG_P53_SIGNALING_PATHWAY",0.30407,0.96,0.515,4224,0.871,"CCND3, CASP9, APAF1, CCNB1, CCNB2, PMAIP1, CHEK1, EI24, ATM, CDK1, DDB2, CASP8, RRM2, SERPINB5, PIDD1, CCNG1, BID, SFN, COP1, FAS, CCNE2, CDK2",0.288192770958809,0.0599818449923368,FALSE +"HCC15","Input","KEGG_PANCREATIC_CANCER",0.28222,0.892,0.618,4555,0.955,"EGF, CHUK, CASP9, SMAD2, MAPK8, E2F3, AKT1, ARAF, TGFA, RAD51, BCL2L1, IKBKG, MAP2K1, CDC42, E2F2, RELA, MAPK9, AKT2, RALB, TGFB1, TGFBR2, CDK6",0.209011524911184,0.0199966284162537,FALSE +"HCC15","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.24745,0.784,0.795,2722,1,"BCAT1, PPCDC, COASY",0.0996328713435297,0,FALSE +"HCC15","Input","KEGG_PARKINSONS_DISEASE",0.21586,0.685,0.894,4757,0.999,"NDUFS3, CASP9, VDAC2, APAF1, SLC18A2, ATP5F1B, PARK7, UCHL1, NDUFA9, UBE2J1, NDUFV3, COX5A, NDUFB10, UBE2G2, ATP5PO, NDUFA2, VDAC1, COX7A2, NDUFB1, ATP5F1C, NDUFS1, NDUFAB1, UBA1, ATP5MC3, ATP5F1D, COX8A, ATP5MC2, CYC1, COX4I1, SDHD, UBE2J2",0.0486624812040823,0.000434511774017692,FALSE +"HCC15","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.43743,1.38,0.0931,5551,0.382,"TUBAL3, CD14, ROCK2, ARPC2, WASL, ARPC5L, KRT18, ABL1, YWHAQ, LY96, ARPC3, CDC42, NCL, TUBB3, ARPC4, ARPC1A, TUBB2A, YWHAZ, ITGB1, TUBA1C, TUBB, TUBA4A, CTTN, TUBA1B, EZR, PRKCA, CDH1",1.03105031901866,0.417936637088291,FALSE +"HCC15","Input","KEGG_PATHWAYS_IN_CANCER",0.2259,0.705,0.887,5626,0.991,"FGF9, COL4A6, FGF19, CSF2RA, EGF, KIT, CHUK, CASP9, EGLN1, RASSF5, SMAD2, SLC2A1, AXIN2, BMP4, PPARD, MAPK8, TRAF2, MSH2, TPR, E2F3, ABL1, CKS1B, AKT1, CTNNA1, ARAF, TGFA, CUL2, FZD3, RAD51, NCOA4, HDAC1, BCL2L1, GLI2, EGLN3, CTBP2, IKBKG, APC, NFKBIA, MAP2K1, CBL, CDC42, CASP8, WNT3, MSH3, E2F2, MSH6, PIAS1, COL4A4, PTGS2, MTOR, RELA, SUFU, APPL1, LEF1, JUP, ITGA2, HRAS, DVL1, LAMB3, CXCL8, BID, HSP90AA1, MAPK9, AKT2, RALB, FAS, HSP90AB1, CCNE2, NRAS, CDK2, TGFB1, PML, IGF1R, TGFBR2, ELOC, SOS1, XIAP, CDK6, TPM3, ITGA6, ITGB1, FZD9, VHL, FGF3, FZD6, PIK3R1, CCDC6, RXRA, SOS2, BIRC5, ELOB, TCF7, PTEN, BIRC2, LAMA1, TCF7L2, TRAF6, TRAF3, PRKCA, CDH1, FZD1, HDAC2, CRK, BIRC3, CDKN1B, LAMB2",0.0520763801682736,0.00392634551472468,FALSE +"HCC15","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.48286,1.52,0.0425,3070,0.353,"UGDH, RPEL1, GUSB, DCXR, RPE",1.37161106994969,0.452225294612177,FALSE +"HCC15","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.53817,1.7,0.0224,3070,0.28,"PGD, TALDO1, G6PD, PFKP, RBKS, RPEL1, H6PD, GPI, TKT, ALDOA, RPE",1.64975198166584,0.552841968657781,FALSE +"HCC15","Input","KEGG_PEROXISOME",0.28942,0.921,0.572,6744,0.929,"PRDX1, SCP2, SLC27A2, MPV17L, NUDT19, SOD1, DECR2, ABCD1, ACOX1, GNPAT, PEX6, PEX1, DHRS4, PECR, MPV17, PEX13, PEX14, PEX7, CRAT, GSTK1, FAR1, CROT, PEX16, PHYH, EPHX2, PEX3, ABCD3, ACSL3, SOD2, PEX11B, IDH1, PMVK, AGPS, ECI2, ACSL1",0.242603971206976,0.0319842860063582,FALSE +"HCC15","Input","KEGG_PHENYLALANINE_METABOLISM",0.45266,1.41,0.0855,3387,0.384,"ALDH3A1, PAH, PRDX6, ALDH3B1, GOT2, MAOA",1.06803388527183,0.415668775632469,FALSE +"HCC15","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.22546,0.714,0.872,5224,0.988,"ITPR1, SYNJ1, CALM3, DGKG, CALM1, IPPK, PLCD4, IMPA1, PIKFYVE, DGKD, PIK3C2A, INPP5A, ITPK1, ITPR3, ITPKA, ITPKB, PLCD3, IMPA2, CALML6, PIK3R1, CALM2, DGKA, CDIPT, INPP1, PTEN",0.0594835150674328,0.00524305541237188,FALSE +"HCC15","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.39101,1.24,0.176,1990,0.499,"HMBS, EARS2, BLVRA, UROS, GUSB, BLVRB",0.75448733218585,0.30189945437661,FALSE +"HCC15","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.2493,0.773,0.805,1391,1,"SCP2, SLC27A2, PDPK1, ME1, PPARD, PPARA, CYP27A1",0.0942041196321315,0,FALSE +"HCC15","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.64526,2.03,0,1700,0.17,"CYP39A1, SCP2, CYP27A1, HSD3B7",Inf,0.769551078621726,TRUE +"HCC15","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.25478,-0.927,0.535,11935,1,"CD79A, CD8B, TAP2, AICDA, AIRE, RFXAP, BTK, CD3D, IL2RG, CIITA, IGLL1, LCK, RAG1, BLNK, CD8A, JAK3, RFX5, IL7R, RFXANK",0.271646217978772,0,FALSE +"HCC15","Input","KEGG_PRION_DISEASES",0.24516,0.779,0.784,3165,1,"CCL5, STIP1, SOD1, MAP2K1, PRKACB, C5",0.105683937315562,0,FALSE +"HCC15","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.42902,1.36,0.103,4818,0.368,"PDE3A, CDC25C, CDC23, INS, PLK1, ANAPC4, BUB1, CCNB1, ADCY9, ADCY7, MAPK8, CCNB2, ANAPC5, MAPK14, AKT1, ARAF, CDK1, MAP2K1, PRKACB, MAPK13, CDC25B, ANAPC7, GNAI1, HSP90AA1, MAPK9, AKT2, RPS6KA1, CDC27, GNAI3, HSP90AB1, CDK2, IGF1R, CCNA2, PIK3R1, ANAPC2",0.987162775294828,0.434152181326482,FALSE +"HCC15","Input","KEGG_PROPANOATE_METABOLISM",0.32908,1.04,0.41,5284,0.783,"HADHA, ALDH9A1, LDHA, HIBCH, MCEE, ALDH3A2, ACAT1, ALDH2, ACACA, ECHS1, ACSS2, LDHAL6B, ALDH7A1, ACACB, LDHB",0.387216143280265,0.106238237942057,FALSE +"HCC15","Input","KEGG_PROSTATE_CANCER",0.23815,0.746,0.841,4450,1,"EGF, CHUK, PDPK1, INS, CASP9, E2F3, AKT1, ARAF, TGFA, IKBKG, NFKBIA, MAP2K1, CREB3L2, E2F2, MTOR, RELA, LEF1, HRAS, HSP90AA1, AKT2, HSP90AB1, CCNE2, NRAS, CDK2, IGF1R, SOS1",0.0752040042020878,0,FALSE +"HCC15","Input","KEGG_PROTEASOME",0.48553,1.56,0.0378,4892,0.319,"PSMC6, PSMA6, PSMA1, PSMC1, PSMA4, PSMC3, PSMB1, PSMA5, PSMB2, PSME2, PSMD1, PSMD14, PSMD8, PSMD13, PSMC2, PSMD4, PSMB7, PSME1, PSMD12, PSME4, PSMA2, PSMD7",1.42250820016277,0.496209316942819,FALSE +"HCC15","Input","KEGG_PROTEIN_EXPORT",0.4637,1.49,0.0644,5209,0.356,"SRP54, SEC11A, SEC63, SRP9, SRPRA, SRP72, SRP19, SRP68, SEC61A2, SRP14, SPCS2, SEC61B",1.19111413264019,0.448550002027125,FALSE +"HCC15","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.20006,-0.709,0.84,11762,0.954,"ATP1B4, ATP1A4, SLC9A3, ATP1B3, PCK1, GLS, GLS2, ATP1B2, PCK2, ATP1A2, FXYD2, SLC4A4, AQP1, ATP1A3, CA2",0.0757207139381184,0.0204516252959049,FALSE +"HCC15","Input","KEGG_PURINE_METABOLISM",0.39136,1.22,0.199,4668,0.532,"PDE7B, PDE8B, PDE4D, PDE3A, PDE8A, PDE10A, ADCY10, PDE4B, POLR2J2, PDE2A, ENTPD8, RRM1, ADCY9, ADCY7, POLE2, POLE3, ATIC, ADK, POLR2E, PDE9A, POLA1, PRIM1, POLR3K, POLR2D, NT5C2, POLR2A, NT5M, POLR1A, NT5E, NUDT5, RRM2, POLA2, PRIM2, POLR2C, POLD3, POLR3A, PKM, POLR2L, GART, NME3, PDE6D, PDE7A, AMPD3, POLR2G, AK2, NT5C3A, POLR3B, POLR1C, POLR1B, POLD1, GMPR2, APRT, GUK1, PRPS1, ADA",0.701146923590293,0.274088367704952,FALSE +"HCC15","Input","KEGG_PYRIMIDINE_METABOLISM",0.38203,1.21,0.175,4243,0.544,"POLR2J2, CTPS1, ENTPD8, TXNRD1, DTYMK, RRM1, POLE2, POLE3, CMPK1, DHODH, POLR2E, POLA1, CDA, PRIM1, POLR3K, POLR2D, NT5C2, DUT, POLR2A, NT5M, POLR1A, NT5E, RRM2, POLA2, PRIM2, POLR2C, POLD3, POLR3A, POLR2L, CAD, NME3, POLR2G, UCK2, NT5C3A, POLR3B, POLR1C, POLR1B, POLD1",0.756961951313706,0.26440110030182,FALSE +"HCC15","Input","KEGG_PYRUVATE_METABOLISM",0.38381,1.2,0.207,5284,0.547,"PC, ME1, DLAT, ME3, ALDH9A1, LDHA, ALDH3A2, ACAT1, GLO1, PKM, ALDH2, ACACA, DLD, ACSS2, LDHAL6B, ALDH7A1, ACACB, LDHB",0.684029654543082,0.262012673666569,FALSE +"HCC15","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.27296,0.858,0.681,5845,0.981,"FGF9, FGF19, CD14, ITGA10, EGF, CFL2, INS, ROCK2, ITGA1, GNA13, IQGAP2, IQGAP1, ARPC2, DIAPH1, WASL, ARPC5L, ARHGEF4, MYLK2, ARAF, ITGB5, NCKAP1, WASF2, APC, ARPC3, MAP2K1, ARHGEF12, PIKFYVE, BRK1, CDC42, ARHGAP35, ITGB7, PPP1CC, CYFIP1, CFL1, ITGB4, IQGAP3, ACTN4, FGD1, ITGA2, HRAS, PXN, MSN, LIMK1, PPP1CA, ARHGEF1, NRAS, ARPC4, PPP1CB, SSH1, SOS1, ARPC1A, ITGB2, ITGA6, ITGB1, MYH10, RDX, FGF3, PIK3R1, DIAPH2, SOS2, F2R, RRAS2, EZR, PAK1, ITGA11, PFN4, RRAS, CRK, VCL, BCAR1, ITGAE, MAPK3, MYLPF, PIP4K2C",0.166852888087215,0.0083309926200515,FALSE +"HCC15","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.25687,0.81,0.743,4928,1,"PRKAA2, INS, ULK3, ATG4A, ATG12, GABARAPL2, ATG4C, ULK2, ATG5, PRKAA1",0.129011186239425,0,FALSE +"HCC15","Input","KEGG_RENAL_CELL_CARCINOMA",-0.21133,-0.784,0.709,17066,0.962,"RBX1, FLCN, MAP2K2, VEGFB, ARNT2, PGF, PIK3CD, AKT3, EP300, PIK3R2, JUN, GAB1",0.149353764816933,0.0168249279621871,FALSE +"HCC15","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.34697,-1.29,0.187,13968,1,"CMA1, AGT, CTSG, AGTR1, ACE, ENPEP, MME, ANPEP, CTSA",0.728158393463501,0,FALSE +"HCC15","Input","KEGG_RETINOL_METABOLISM",-0.28828,-1.07,0.352,10894,0.941,"UGT2B11, CYP4A11, CYP2A13, ADH1B, RDH8, ADH7, ADH4, UGT2B17, CYP1A2, ADH1A, AWAT2, CYP3A43, UGT2A1, UGT2A3, UGT2B15, CYP2A7, DGAT2, RPE65, CYP2C18, CYP2B6, CYP2C9, CYP4A22, ADH1C, CYP2A6, CYP2C8, DHRS3, RDH16, CYP26A1, BCO1, CYP3A4, ADH6, DHRS9, UGT2B7, ADH5, LRAT, RDH12, CYP26B1, RDH10, ALDH1A2, RDH11",0.453457336521869,0.0264103765727431,FALSE +"HCC15","Input","KEGG_RIBOFLAVIN_METABOLISM",0.41116,1.32,0.11,6028,0.402,"RFK, ACP2, MTMR2, ACP1, FLAD1, MTMR7, MTMR6, PHPT1",0.958607314841775,0.39577394691553,FALSE +"HCC15","Input","KEGG_RIBOSOME",-0.45847,-1.71,0.0314,16686,0.571,"RPL27, RPL17, RPL19, RPL28, RPL36A, RPS3A, RPL29, RPLP2, RPL24, RPS6, RPL32, RPL23, RPL21, UBA52, RPL23A, RPSA, RPL37, RPL3, RPL15, RPL18A, RPS28, RPL22L1, RPS19, RPL35A, RPL38, RPL36, RPS21",1.50307035192679,0.243363891754152,FALSE +"HCC15","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.41719,1.31,0.131,3809,0.41,"CHUK, TBK1, MAPK8, TRAF2, DDX3X, MAPK14, NLRX1, IKBKG, NFKBIA, TANK, CASP8, CASP10, MAPK13, ISG15, CYLD, IFIH1, ATG12, RELA, TKFC, RIPK1, MAP3K7, CXCL8, MAPK9",0.882728704344236,0.387216143280265,FALSE +"HCC15","Input","KEGG_RNA_DEGRADATION",0.43595,1.37,0.102,4776,0.36,"ENO3, CNOT8, CNOT9, EXOSC10, ENO1, TTC37, WDR61, PAPOLA, DDX6, HSPD1, EXOSC2, DCPS, LSM2, HSPA9, CNOT1, PARN, EDC4, EXOSC6, CNOT4, MTREX, LSM8, CNOT6, DCP2, C1D, PATL1, PAPOLG, LSM5, SKIV2L",0.991399828238082,0.443697499232713,FALSE +"HCC15","Input","KEGG_RNA_POLYMERASE",0.42722,1.34,0.0967,4194,0.384,"POLR2J2, POLR2E, POLR3K, POLR2D, POLR2A, POLR1A, POLR2C, POLR3A, POLR2L, POLR2G, POLR3B, POLR1C, POLR1B",1.014573525917,0.415668775632469,FALSE +"HCC15","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.47285,1.5,0.0439,5704,0.37,"TRMT11, GGT5, MAT2A, MAT2B, GGT1, SEPHS1, AHCYL2, AHCYL1, METTL2B, BUD23, LCMT2, LCMT1, CTH, SEPHS2",1.35753547975788,0.431798275933005,FALSE +"HCC15","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.27675,0.874,0.63,5626,0.97,"COL4A6, CHUK, CASP9, APAF1, TRAF2, E2F3, CKS1B, AKT1, BCL2L1, IKBKG, NFKBIA, E2F2, PIAS1, COL4A4, PTGS2, RELA, ITGA2, LAMB3, AKT2, CCNE2, CDK2, XIAP, CDK6, ITGA6, ITGB1, PIK3R1, RXRA, PTEN, BIRC2, LAMA1, TRAF6, TRAF3, BIRC3, CDKN1B, LAMB2",0.200659450546418,0.0132282657337552,FALSE +"HCC15","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.25956,0.814,0.729,4869,1,"VAMP1, GOSR1, VTI1A, STX12, VAMP8, VAMP2, VAMP7, VAMP3, STX17, BNIP1, STX7, STX1A, STX4",0.137272471682025,0,FALSE +"HCC15","Input","KEGG_SPHINGOLIPID_METABOLISM",0.36999,1.16,0.242,4954,0.634,"GLA, SGMS1, ACER3, SPTLC1, PLPP3, SMPD4, ASAH2, SGPL1, CERK, DEGS1, SMPD1, SMPD3",0.616184634019569,0.197910742118267,FALSE +"HCC15","Input","KEGG_SPLICEOSOME",0.31462,0.988,0.463,5523,0.845,"SRSF10, DHX15, PRPF4, SNRNP200, PPIL1, RBM22, DDX5, RBM17, AQR, SNRPA1, DDX23, TCERG1, CDC40, THOC2, SF3B1, SMNDC1, PRPF40A, SNRPC, SRSF4, LSM2, SF3B3, SF3B5, THOC3, PPIE, MAGOHB, PRPF38A, PRPF3, PRPF18, SNRNP40, ACIN1, PRPF8, SLU7, NCBP1, CDC5L, PQBP1, LSM8, SF3B2, DDX46, U2AF1, PCBP1, HNRNPK, SNRNP27, HNRNPU, WBP11, USP39, PRPF19, U2AF2, HSPA2, LSM5, BCAS2, DHX38, SF3A3, DDX39B, BUD31, DHX16, HSPA1A, HSPA8, TRA2A, PRPF31, SRSF1, SRSF8, SNRPA",0.334419008982047,0.0731432910503077,FALSE +"HCC15","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.30853,0.954,0.512,5410,0.878,"UGDH, PGM2L1, AGL, GUSB, G6PC2, GPI, HK3, GBE1, HK1, PGM2, UXS1, PGM1",0.290730039024169,0.0565054840938974,FALSE +"HCC15","Input","KEGG_STEROID_BIOSYNTHESIS",-0.39613,-1.53,0.0654,16101,0.758,"CEL, SQLE, DHCR7, DHCR24, FDFT1, MSMO1",1.18442225167573,0.120330794367946,FALSE +"HCC15","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.24083,0.763,0.82,925,1,"AKR1C2, AKR1C1, AKR1C3",0.0861861476162833,0,FALSE +"HCC15","Input","KEGG_SULFUR_METABOLISM",0.52829,1.66,0.0297,6347,0.229,"SULT1A4, BPNT1, SULT1A1, SULT1A2, SULT1A3, SUOX, SULT2B1, PAPSS2",1.52724355068279,0.640164517660112,TRUE +"HCC15","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.32317,-1.28,0.169,13383,0.976,"C8G, FCGR2C, C7, C4A, C3, CD86, CTSG, ELANE, GRIN2B, TNF, ACTN2, FCGR2A, FCGR1A, SNRPB, C2, C1S, C1R, ACTN1, SNRPD3, SNRPD1",0.772113295386326,0.0105501823333082,FALSE +"HCC15","Input","KEGG_TASTE_TRANSDUCTION",0.23334,0.734,0.874,5286,1,"TAS2R20, TAS2R10, TAS1R3, TAS2R4, PRKACB, ITPR3, GNB1, TAS2R14, TAS2R5, TAS2R9, TAS2R13, TAS2R46, SCNN1A",0.058488567365597,0,FALSE +"HCC15","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.51342,1.63,0.0344,2030,0.251,"GGT5, GGT1, CSAD",1.46344155742847,0.600326278518962,FALSE +"HCC15","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.23986,0.763,0.817,3708,1,"PDSS2, ACAT1, IDI1",0.0877779434675845,0,FALSE +"HCC15","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.23666,0.743,0.842,5880,1,"PPP2R1B, ROCK2, SMAD2, BMP4, PPP2R1A, ZFYVE16, SKP1, BMPR1A, SMURF2, ID1, SP1, SMAD5, ID3, ZFYVE9, E2F4, ID2, TGFB1, TGFBR2, ACVR2A, SMAD6, BMPR2, CUL1, BMP8B, RBL1, PPP2CB, BMP6, SMAD7, BMP8A, MAPK3, TGFB2, ID4",0.0746879085003505,0,FALSE +"HCC15","Input","KEGG_THYROID_CANCER",0.32015,0.998,0.442,6141,0.849,"TPR, NCOA4, MAP2K1, LEF1, HRAS, NRAS, TPM3, CCDC6, RXRA, TCF7, TCF7L2, CDH1, MAPK3, 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+
+
+ + + + diff --git a/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_mean_results.csv b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..3458a47 --- /dev/null +++ b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"FGFR inhibitor",0.9162,0.857992940363897,0.030069198759245,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0959901345006666 +"ATPase inhibitor",0.6208,1.49135232016353,9.36310504510649e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H1299",3.88568859371919e-05 +"protein tyrosine kinase inhibitor",0.6128,0.905785783568215,0.42975713550261,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.699408671504247 +"glucocorticoid receptor agonist",0.609533333333333,1.18125840082677,0.0110787610049687,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0656812259580285 +"BCL inhibitor",0.606933333333333,0.83404483150031,0.621374511146836,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.904808498687498 +"calcium channel blocker",0.578066666666667,0.818715672490122,0.759004011802418,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"phosphatase inhibitor",0.575333333333333,0.768837124369996,0.911205326823615,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"progesterone receptor agonist",0.468066666666667,1.14279872410216,0.0656755076850518,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.175840875414816 +"cytochrome P450 inhibitor",0.3726,1.1258243836661,0.175618004518897,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.364407359376711 +"adenosine receptor antagonist",0.369466666666667,1.33455952426616,0.0157155933418918,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0726524699065228 +"src inhibitor",0.363466666666667,0.968520290123523,0.705556812894415,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.993713284596769 +"VEGFR inhibitor",0.338333333333333,0.697819733851359,0.999744184750522,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"serotonin receptor agonist",0.337866666666667,1.42384478822391,0.00245631728942153,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H2126",0.0169895279184989 +"PDGFR tyrosine kinase receptor inhibitor",0.3112,0.846028469632418,0.973925640038297,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"benzodiazepine receptor agonist",0.2956,0.80964011405421,0.989336976160413,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"TGF beta receptor inhibitor",0.2604,1.61097946249213,0.000159628756937528,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H2126, A549, HCC44, H460",0.00220819780430246 +"PPAR receptor agonist",0.259066666666667,1.25642534123411,0.0188884801347523,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, HCC44",0.0825128342728654 +"acetylcholine receptor agonist",0.2202,1.14915895953768,0.196324898565245,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.370340149566257 +"acetylcholine receptor antagonist",0.1542,1.34633222391164,0.094513955260518,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1975, HCC44",0.237716917776454 +"AP inhibitor",0.141,1.20999232583163,0.0911569327526555,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.2364382943272 +"FLT3 inhibitor",0.138866666666667,0.842242658168117,0.995129043207907,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"bromodomain inhibitor",0.1164,1.16407368446209,0.172228930458212,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.364407359376711 +"serotonin receptor antagonist",0.0993333333333334,1.07367191494999,0.573000690991427,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.849268881290866 +"adrenergic receptor antagonist",0.0945333333333333,0.837393052162199,0.997817061564008,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"adrenergic receptor agonist",0.0914666666666667,0.932426394388523,0.950570534799359,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"NFkB pathway inhibitor",0.0823999999999999,0.964384022502003,0.910804602844587,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"androgen receptor antagonist",0.0693333333333334,1.08415573911992,0.492402594028351,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.771121043478361 +"EGFR inhibitor",0.0512,1.28838870576502,0.0293665661422513,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.0959901345006666 +"KIT inhibitor",0.0461333333333334,0.930295334570592,0.950204433007134,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"DNA polymerase inhibitor",0.0448,1.10806705573264,0.422451367009864,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.699408671504247 +"tyrosine kinase inhibitor",0.00293333333333331,0.770198347984527,0.999934762693921,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"Abl kinase inhibitor",-0.00859999999999997,1.00071415927398,0.706374503508547,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.993713284596769 +"protein synthesis inhibitor",-0.0173333333333333,1.00338118854392,0.785356710220923,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"RAF inhibitor",-0.0584666666666667,1.31988662211498,0.0121810065390786,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0674015695162348 +"glutamate receptor antagonist",-0.0634000000000001,1.1067608336299,0.464871545786783,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.742006505775058 +"phosphodiesterase inhibitor",-0.0666,1.13532882587255,0.291083692199713,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.5140414138846 +"estrogen receptor antagonist",-0.0826666666666667,1.16114264330238,0.189565326907583,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.370340149566257 +"bacterial 50S ribosomal subunit inhibitor",-0.119266666666667,0.978222912564752,0.884785409782261,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"microtubule inhibitor",-0.126933333333333,0.99976643462837,0.787673271358329,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"sodium channel blocker",-0.133533333333333,0.736048607349374,0.999978508673811,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"growth factor receptor inhibitor",-0.1378,1.30802567689957,0.0091688665224188,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H460, H520",0.05853968625852 +"retinoid receptor agonist",-0.141133333333333,1.27462290595335,0.0291443526088252,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0959901345006666 +"sterol demethylase inhibitor",-0.146,1.37631033668179,0.00159271892090739,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2126, H520",0.0120177882213921 +"CHK inhibitor",-0.154066666666667,1.28560777548246,0.0208896057538746,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.0825636798843614 +"HCV inhibitor",-0.156066666666667,1.50097275442421,4.50015508622314e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC827, H1650, H1975, H1703",9.33782180391301e-05 +"AKT inhibitor",-0.162266666666667,1.10037769273403,0.422168329981753,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.699408671504247 +"histamine receptor antagonist",-0.193666666666667,1.27742920780464,0.0206568243558195,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0825636798843614 +"proteasome inhibitor",-0.213666666666667,1.37313659016068,0.000231270238480103,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.00274220425626408 +"Bcr.Abl kinase inhibitor",-0.223266666666667,0.990674839740688,0.750415427964132,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.999978508673811 +"JAK inhibitor",-0.229266666666667,0.814583282304224,0.997966326380623,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"tubulin polymerization inhibitor",-0.2384,1.15621734239595,0.156532623304893,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.341900203534372 +"potassium channel blocker",-0.252666666666667,1.23499037975817,0.0300316428609227,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.0959901345006666 +"PI3K inhibitor",-0.263733333333333,0.846565115769659,0.989487270475967,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"RET tyrosine kinase inhibitor",-0.2872,1.12565709064274,0.210363880439205,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.388004490587868 +"antioxidant",-0.296066666666667,1.36460546190709,0.00102822113293202,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1975, HCC44",0.00853423540333575 +"PLK inhibitor",-0.311933333333333,1.70990569776175,9.6191803046972e-10,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1650, H2126, HCC15, HCC44, H520",7.98391965289868e-08 +"ALK tyrosine kinase receptor inhibitor",-0.319066666666667,0.967549442565869,0.787528701789879,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"vitamin D receptor agonist",-0.326266666666667,1.23341630480239,0.0456398561504446,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC15",0.135289573588818 +"estrogen receptor agonist",-0.3272,0.857796612590321,0.96406610591418,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"HSP inhibitor",-0.327866666666667,1.12482727986292,0.125041034601526,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.280497455998019 +"glycogen synthase kinase inhibitor",-0.334466666666667,1.12353967866018,0.189849146947467,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.370340149566257 +"CDK inhibitor",-0.344066666666667,0.91582760906396,0.889024121628442,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"dopamine receptor antagonist",-0.352333333333333,0.856170182237376,0.947355559890469,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"p38 MAPK inhibitor",-0.3578,1.2308087468931,0.0157559573291254,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.0726524699065228 +"DNA inhibitor",-0.369466666666667,1.09348472238767,0.192163009166042,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.370340149566257 +"thymidylate synthase inhibitor",-0.376666666666667,1.49168493737148,1.67848050448913e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H520",4.64379606241994e-05 +"DNA alkylating agent",-0.394733333333333,1.00873403451106,0.507557488038412,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.780134657540523 +"mTOR inhibitor",-0.395333333333333,0.995020004584737,0.526227088623088,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.794124515558478 +"opioid receptor agonist",-0.398133333333333,1.06978681899491,0.220978230126144,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.398721589140651 +"ribonucleotide reductase inhibitor",-0.398266666666667,1.05213731224091,0.342529437351386,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.592290485420106 +"Aurora kinase inhibitor",-0.465533333333333,1.07604964480977,0.113999952027774,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.270342743380149 +"CC chemokine receptor antagonist",-0.469066666666667,1.13130673285786,0.0579335420765324,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.160282799745073 +"DNA synthesis inhibitor",-0.472866666666667,0.768688481084751,0.98134677846643,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"DNA methyltransferase inhibitor",-0.486133333333333,1.31521605322725,5.59832282417323e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H3255",0.000929321588812755 +"HDAC inhibitor",-0.4922,1.0863880653668,0.118991435765717,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.274341365793182 +"cyclooxygenase inhibitor",-0.503133333333333,0.757398259708539,0.971837038853256,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811 +"PARP inhibitor",-0.551266666666667,1.16695026621083,0.0150758992112059,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.0726524699065228 +"bacterial DNA gyrase inhibitor",-0.6374,0.994741876066349,0.112998314978189,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.270342743380149 +"topoisomerase inhibitor",-0.645133333333333,1.1862686317469,0.0248656103112547,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.0938111661742792 +"MDM inhibitor",-0.6568,1.31819184599858,0.000910684996862495,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC15, H460",0.00839853941550968 +"HMGCR inhibitor",-0.758533333333333,1.05680433833506,0.0550640123102416,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H1975",0.157597000750002 +"MEK inhibitor",-0.835733333333333,1.07522459226411,0.0330433550493935,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1975, HCC15",0.101577721077765 +"MET inhibitor",-0.849733333333333,1.08040855147265,0.00053522755950158,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.00555298592982889 diff --git a/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_results.csv b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_results.csv new file mode 100644 index 0000000..97a7568 --- /dev/null +++ b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_results.csv @@ -0,0 +1,1246 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"HCC827","Pearson.est","EGFR inhibitor",-0.35603,-0.909,0.584,1008,0.942,"vandetanib, canertinib, OSI.420, BMS.599626, BIBX.1382, AEE788, afatinib, tyrphostin.AG.1478, lapatinib, osimertinib, pelitinib, PD.168393, WZ8040, PD.153035, TAK.285, erlotinib, icotinib, BIBU.1361",0.233587152887601,0.0259490972071227,FALSE +"HCC827","Pearson.est","Abl kinase inhibitor",-0.26555,-0.659,0.873,991,0.92,"imatinib, KW.2449, bosutinib, tozasertib, bafetinib, metatinib",0.0589857562944303,0.0362121726544447,FALSE +"HCC827","Pearson.est","acetylcholine receptor agonist",-0.29525,-0.742,0.766,1266,0.894,"tremorine",0.115771230367396,0.0486624812040823,FALSE +"HCC827","Pearson.est","acetylcholine receptor antagonist",0.40178,1.05,0.386,200,1,"methscopolamine, hyoscyamine",0.413412695328245,0,FALSE +"HCC827","Pearson.est","adenosine receptor antagonist",-0.38674,-0.949,0.523,860,0.916,"MRS.1220, sulmazole, CGS.15943",0.281498311132726,0.0381045263321496,FALSE +"HCC827","Pearson.est","adrenergic receptor agonist",-0.34545,-0.86,0.602,1077,0.812,"oxymetazoline, metaraminol, buphenine, terbutaline, epinephrine, isoxsuprine",0.220403508742175,0.0904439707588247,FALSE +"HCC827","Pearson.est","adrenergic receptor antagonist",0.32003,0.876,0.563,123,1,"atipamezole, dihydroergocristine, atenolol......, metoprolol",0.249491605148654,0,FALSE +"HCC827","Pearson.est","AKT inhibitor",-0.47425,-1.17,0.277,1041,0.697,"GDC.0068, AZD5363, CCT128930, uprosertib, palomid.529, triciribine",0.557520230935551,0.156767221901991,FALSE +"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.49651,-1.23,0.244,980,0.631,"alectinib, NVP.TAE684, AZD3463, lorlatinib, CEP.37440, GW.788388",0.612610173661271,0.199970640755866,FALSE +"HCC827","Pearson.est","androgen receptor antagonist",0.25589,0.684,0.856,1079,1,"RU.58841, enzalutamide, nilutamide, flutamide, bicalutamide, cyproterone.acetate",0.0675262353228468,0,FALSE +"HCC827","Pearson.est","antioxidant",0.42014,1.16,0.286,22,1,"trolox",0.543633966870957,0,FALSE +"HCC827","Pearson.est","AP inhibitor",-0.48231,-1.24,0.212,1326,0.681,"LCL.161, embelin",0.673664139071249,0.166852888087215,FALSE +"HCC827","Pearson.est","ATPase inhibitor",0.67635,1.87,0.0199,283,0.534,"k.strophanthidin, oligomycin.a, evodiamine, digoxin, blebbistatin...., NMS.873, digitoxin",1.70114692359029,0.272458742971444,FALSE +"HCC827","Pearson.est","Aurora kinase inhibitor",-0.23431,-0.578,0.938,940,0.975,"MK.8745, AMG900, hesperadin, KW.2449, alisertib, tozasertib, ZM.447439, PF.03814735, MLN.8054",0.0277971616209356,0.0109953843014632,FALSE +"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.35155,0.937,0.513,105,1,"josamycin, radezolid",0.289882634888184,0,FALSE +"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",-0.34028,-0.851,0.621,1395,0.788,"novobiocin",0.20690839982342,0.103473782510445,FALSE +"HCC827","Pearson.est","BCL inhibitor",0.42712,1.17,0.245,364,1,"TW.37, ABT.737, gossypol, obatoclax, venetoclax",0.610833915635468,0,FALSE +"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",-0.28335,-0.702,0.842,991,0.907,"imatinib, bosutinib, tozasertib, bafetinib, metatinib",0.0746879085003505,0.0423927129399047,FALSE +"HCC827","Pearson.est","benzodiazepine receptor agonist",-0.18815,-0.475,0.989,270,1,"temazepam, gamma.aminobutyric.acid, bentazepam, eprinomectin, CL.218872, lorazepam, nefiracetam, ivermectin, ZK.93423, piperazine, indiplon, zaleplon, CGS.20625",0.0048037084028206,0,FALSE +"HCC827","Pearson.est","bromodomain inhibitor",-0.35445,-0.867,0.632,1171,0.843,"JQ1....",0.199282921717615,0.0741724253752577,FALSE +"HCC827","Pearson.est","calcium channel blocker",0.46778,1.3,0.169,74,1,"carboxyamidotriazole, efonidipine.monoethanolate",0.772113295386326,0,FALSE +"HCC827","Pearson.est","CC chemokine receptor antagonist",-0.34913,-0.879,0.59,1442,0.866,"navarixin",0.229147988357856,0.0624821079826534,FALSE +"HCC827","Pearson.est","CDK inhibitor",-0.38755,-0.972,0.487,1224,0.899,"kenpaullone, PHA.793887, arcyriaflavin.a, alvocidib, AZD5438",0.312471038785366,0.0462403082667712,FALSE +"HCC827","Pearson.est","CHK inhibitor",-0.65198,-1.64,0.0435,1146,0.584,"SCH.900776, LY2606368, LY2603618",1.36151074304536,0.233587152887601,FALSE +"HCC827","Pearson.est","cyclooxygenase inhibitor",-0.39783,-0.989,0.471,952,0.894,"ketoprofen, suxibuzone, acetylsalicylsalicylic.acid, FR.122047, meloxicam, AM.404, ramifenazone, aspirin, curcumin, indoprofen, amfenac, FK.3311",0.326979092871104,0.0486624812040823,FALSE +"HCC827","Pearson.est","cytochrome P450 inhibitor",-0.30142,-0.757,0.764,1302,0.894,"cobicistat",0.11690664142431,0.0486624812040823,FALSE +"HCC827","Pearson.est","DNA alkylating agent",-0.43531,-1.09,0.35,929,0.709,"ifosfamide, estramustine, satraplatin, dianhydrogalactitol, melphalan, streptozotocin, TH.302, dacarbazine",0.455931955649724,0.149353764816933,FALSE +"HCC827","Pearson.est","DNA inhibitor",-0.28137,-0.708,0.807,1287,0.92,"melphalan, nithiamide, busulfan",0.0931264652779296,0.0362121726544447,FALSE +"HCC827","Pearson.est","DNA methyltransferase inhibitor",-0.6256,-1.54,0.0501,1273,0.349,"fdcyd, decitabine, azacitidine",1.30016227413275,0.45717457304082,FALSE +"HCC827","Pearson.est","DNA polymerase inhibitor",0.28047,0.755,0.74,47,1,"menadione",0.130768280269024,0,FALSE +"HCC827","Pearson.est","DNA synthesis inhibitor",-0.36941,-0.933,0.519,1301,0.921,"anisomycin, floxuridine, altretamine",0.284832642151542,0.0357403698031511,FALSE +"HCC827","Pearson.est","dopamine receptor antagonist",-0.34568,-0.878,0.602,1204,0.844,"oxiperomide, acetophenazine, amisulpride, isofloxythepin",0.220403508742175,0.073657553374345,FALSE +"HCC827","Pearson.est","estrogen receptor agonist",0.25796,0.702,0.808,199,1,"erteberel, estrone",0.0925886392254138,0,FALSE +"HCC827","Pearson.est","estrogen receptor antagonist",-0.42994,-1.09,0.375,1411,0.709,"raloxifene",0.425968732272281,0.149353764816933,FALSE +"HCC827","Pearson.est","FGFR inhibitor",0.41475,1.14,0.277,260,0.989,"erdafitinib, dovitinib, lenvatinib, nintedanib",0.557520230935551,0.0048037084028206,FALSE +"HCC827","Pearson.est","FLT3 inhibitor",0.27451,0.756,0.738,201,1,"GTP.14564, ponatinib, ENMD.2076, dovitinib, TG.101348",0.131943638176958,0,FALSE +"HCC827","Pearson.est","glucocorticoid receptor agonist",0.66188,1.74,0.0274,328,0.542,"hydrocortisone, triamcinolone, beclomethasone.dipropionate, halcinonide, dexamethasone.acetate, triamcinolone.acetonide, desonide, betamethasone, deflazacort, flumethasone.pivalate, clobetasol.propionate, ciclesonide, fluocinolone.acetonide, methylprednisolone, rimexolone, piretanide, prednisolone.hemisuccinate, fluticasone.propionate",1.56224943717961,0.266000713461613,FALSE +"HCC827","Pearson.est","glutamate receptor antagonist",-0.36112,-0.884,0.608,910,0.88,"IEM1754, ACDPP, LY456236, latrepirdine, MTPG, SIB.1757, diazooxonorleucine",0.216096420727265,0.0555173278498314,FALSE +"HCC827","Pearson.est","glycogen synthase kinase inhibitor",-0.64259,-1.58,0.0549,1224,0.416,"kenpaullone, LY2090314, GSK.3.inhibitor.IX, AZD2858",1.26042765554991,0.380906669373257,FALSE +"HCC827","Pearson.est","growth factor receptor inhibitor",0.25399,0.706,0.819,1082,1,"PHA.848125, GSK1904529A, lestaurtinib, danusertib, GSK1838705A, GW.441756, AZD3463",0.0867160982395816,0,FALSE +"HCC827","Pearson.est","HCV inhibitor",-0.72311,-1.81,0.00598,1149,0.248,"PSI.7976, daclatasvir, Ro.9187, embelin",2.22329881601159,0.605548319173784,TRUE +"HCC827","Pearson.est","HDAC inhibitor",-0.56356,-1.42,0.117,1104,0.467,"givinostat, vorinostat, nexturastat.a, entinostat, M.344, dacinostat, R306465, romidepsin, panobinostat, PCI.24781, SB.939, tacedinaline, JNJ.26481585",0.931814138253838,0.330683119433888,FALSE +"HCC827","Pearson.est","histamine receptor antagonist",-0.54969,-1.37,0.13,1076,0.498,"cyproheptadine, ICI.162846, pheniramine, terfenadine, levocetirizine, tiotidine, ranitidine, tecastemizole, zolantidine, chloropyramine",0.886056647693163,0.302770657240282,FALSE +"HCC827","Pearson.est","HMGCR inhibitor",-0.48065,-1.22,0.227,1237,0.62,"mevastatin, simvastatin",0.643974142806877,0.207608310501746,FALSE +"HCC827","Pearson.est","HSP inhibitor",-0.65283,-1.63,0.0388,1108,0.464,"alvespimycin, tanespimycin, SNX.5422, BIIB021, SNX.2112, XL888, NVP.AUY922, VER.49009, PU.H71",1.41116827440579,0.333482019445119,FALSE +"HCC827","Pearson.est","JAK inhibitor",0.25639,0.695,0.834,203,1,"AT.9283, filgotinib, TG.101209, TG.101348, AZ960",0.0788339493622613,0,FALSE +"HCC827","Pearson.est","KIT inhibitor",-0.17949,-0.452,0.991,919,0.992,"KI.8751, imatinib, vatalanib, sunitinib, tandutinib, telatinib",0.00392634551472468,0.00348832784582135,FALSE +"HCC827","Pearson.est","MDM inhibitor",-0.34106,-0.862,0.581,1124,0.83,"serdemetan, RITA",0.235823867609669,0.0809219076239261,FALSE +"HCC827","Pearson.est","MEK inhibitor",-0.54892,-1.37,0.144,1050,0.498,"arctigenin, AS.703026, AZD8330, PD.184352, cobimetinib, MEK162, trametinib, Ro.4987655, TAK.733, BIX.02188, nobiletin",0.84163750790475,0.302770657240282,FALSE +"HCC827","Pearson.est","MET inhibitor",-0.60793,-1.46,0.0763,1045,0.427,"LY2801653, PF.04217903, AMG458, INC.280",1.11747546204512,0.369572124974976,FALSE +"HCC827","Pearson.est","microtubule inhibitor",-0.35709,-0.9,0.549,1200,0.93,"cabazitaxel, podophyllotoxin",0.260427655549908,0.0315170514460649,FALSE +"HCC827","Pearson.est","mTOR inhibitor",0.18114,0.492,0.975,286,1,"voxtalisib, torin.1, XL388, PF.04691502, OSI.027, WYE.125132, WYE.354, AZD2014",0.0109953843014632,0,FALSE +"HCC827","Pearson.est","NFkB pathway inhibitor",0.35786,0.961,0.471,49,1,"EVP4593, tyloxapol",0.326979092871104,0,FALSE +"HCC827","Pearson.est","opioid receptor agonist",-0.35867,-0.896,0.579,1389,0.909,"salvinorin.a",0.237321436272564,0.0414361167780325,FALSE +"HCC827","Pearson.est","p38 MAPK inhibitor",-0.64396,-1.6,0.044,1268,0.446,"TAK.715, VX.702, CMPD.1",1.35654732351381,0.350665141287858,FALSE +"HCC827","Pearson.est","PARP inhibitor",-0.58796,-1.48,0.0863,897,0.428,"E7449, AZD2461, talazoparib, olaparib, PJ.34, niraparib",1.06398920428479,0.368556230986828,FALSE +"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.19394,0.529,0.963,375,1,"dasatinib, ponatinib, dovitinib, lenvatinib, axitinib, nintedanib, motesanib, masitinib, linifanib, pazopanib",0.0163737128754655,0,FALSE +"HCC827","Pearson.est","phosphatase inhibitor",0.38189,1.02,0.395,47,1,"GSK2830371, menadione",0.40340290437354,0,FALSE +"HCC827","Pearson.est","phosphodiesterase inhibitor",-0.51667,-1.32,0.165,1037,0.572,"cilostamide, papaverine, EMD.53998, GSK256066, zardaverine, YM.976",0.782516055786094,0.242603971206976,FALSE +"HCC827","Pearson.est","PI3K inhibitor",0.20965,0.562,0.936,241,1,"voxtalisib, buparlisib, ZSTK.474, PF.04691502, PI.828, GDC.0941, idelalisib",0.0287241512618947,0,FALSE +"HCC827","Pearson.est","PLK inhibitor",0.30049,0.811,0.644,1015,1,"volasertib, NMS.1286937, GW.843682X, rigosertib, HMN.214, GSK461364, BI.2536",0.191114132640188,0,FALSE +"HCC827","Pearson.est","potassium channel blocker",-0.52176,-1.29,0.18,1175,0.602,"oleoylethanolamide, meglitinide",0.744727494896694,0.220403508742175,FALSE +"HCC827","Pearson.est","PPAR receptor agonist",0.18876,0.503,0.984,1176,1,"clofibrate, fenofibrate, pterostilbene, S26948, ciprofibrate, GW.501516, oleoylethanolamide",0.00700490156865849,0,FALSE +"HCC827","Pearson.est","progesterone receptor agonist",0.54686,1.49,0.103,26,0.976,"norethindrone, tanaproget",0.987162775294828,0.0105501823333082,FALSE +"HCC827","Pearson.est","proteasome inhibitor",-0.72327,-1.82,0.00633,1170,0.47,"carfilzomib, bortezomib, ONX.0914, delanzomib, ixazomib, ixazomib.citrate",2.19859628998264,0.327902142064283,FALSE +"HCC827","Pearson.est","protein synthesis inhibitor",0.2476,0.652,0.865,191,1,"clofoctol, clindamycin.phosphate, harringtonine, florfenicol",0.0629838925351858,0,FALSE +"HCC827","Pearson.est","protein tyrosine kinase inhibitor",0.36425,0.973,0.472,114,1,"mubritinib, PP.121",0.326058001365912,0,FALSE +"HCC827","Pearson.est","RAF inhibitor",-0.61835,-1.54,0.0602,1296,0.349,"LGX818, GDC.0879, CEP.32496, vemurafenib, dabrafenib",1.22040350874218,0.45717457304082,FALSE +"HCC827","Pearson.est","RET tyrosine kinase inhibitor",-0.46037,-1.15,0.298,1008,0.709,"vandetanib, sunitinib, apatinib",0.525783735923745,0.149353764816933,FALSE +"HCC827","Pearson.est","retinoid receptor agonist",-0.341,-0.858,0.612,1215,0.796,"tamibarotene, AM.580, CD.437",0.213248577854439,0.0990869322623309,FALSE +"HCC827","Pearson.est","ribonucleotide reductase inhibitor",-0.45848,-1.13,0.328,1211,0.688,"gemcitabine, fludarabine.phosphate, clofarabine, fludarabine",0.484126156288321,0.162411561764489,FALSE +"HCC827","Pearson.est","serotonin receptor agonist",0.4792,1.29,0.179,179,0.946,"NAN.190, zolmitriptan, aripiprazole",0.747146969020107,0.0241088635982073,FALSE +"HCC827","Pearson.est","serotonin receptor antagonist",0.29723,0.812,0.637,179,1,"pirenperone, SB.200646, aripiprazole",0.19586056766465,0,FALSE +"HCC827","Pearson.est","sodium channel blocker",0.24279,0.693,0.839,90,1,"cibenzoline, oxcarbazepine",0.0762380391712997,0,FALSE +"HCC827","Pearson.est","src inhibitor",-0.26735,-0.669,0.871,1032,0.927,"bosutinib, PP.2, saracatinib, KX2.391",0.0599818449923368,0.0329202658555029,FALSE +"HCC827","Pearson.est","sterol demethylase inhibitor",0.47349,1.29,0.195,197,0.946,"posaconazole, sulconazole, chlormidazole, terconazole",0.709965388637482,0.0241088635982073,FALSE +"HCC827","Pearson.est","TGF beta receptor inhibitor",-0.4683,-1.14,0.3,1191,0.697,"repsox, D.4476, LY2109761",0.522878745280338,0.156767221901991,FALSE +"HCC827","Pearson.est","thymidylate synthase inhibitor",-0.61796,-1.57,0.0651,1250,0.38,"carmofur, raltitrexed, doxifluridine",1.18641901143181,0.42021640338319,FALSE +"HCC827","Pearson.est","topoisomerase inhibitor",-0.49626,-1.23,0.239,1183,0.631,"amsacrine, etoposide, nemorubicin, rubitecan, SN.38, irinotecan, licochalcone.a, camptothecin, exatecan.mesylate, genz.644282",0.621602099051862,0.199970640755866,FALSE +"HCC827","Pearson.est","tubulin polymerization inhibitor",-0.35576,-0.885,0.613,1089,0.904,"epothilone.d, fosbretabulin, KX2.391, plinabulin, taltobulin, mebendazole, podophyllotoxin, combretastatin.A.4",0.212539525481585,0.0438315695246367,FALSE +"HCC827","Pearson.est","tyrosine kinase inhibitor",0.22136,0.599,0.932,133,1,"mubritinib, GTP.14564, PP.121, dasatinib",0.0305840876460186,0,FALSE +"HCC827","Pearson.est","VEGFR inhibitor",0.12888,0.343,1,375,1,"SAR131675, ENMD.2076, dovitinib, lenvatinib, axitinib, ZM.306416, nintedanib, semaxanib, motesanib, linifanib, cediranib, pazopanib",0,0,FALSE +"HCC827","Pearson.est","vitamin D receptor agonist",-0.34162,-0.844,0.627,1029,0.781,"maxacalcitol, calcitriol, ercalcitriol",0.202732459169284,0.1073489661227,FALSE +"HCC95","Pearson.est","EGFR inhibitor",-0.20296,-0.494,0.974,754,1,"afatinib, gefitinib, vandetanib, dacomitinib, osimertinib, PD.153035, neratinib, brigatinib, tucatinib, tyrphostin.AG.494, GW.583340, BIBU.1361, erlotinib, lapatinib, OSI.420, WZ8040, TAK.285, CP.724714, AEE788, BIBX.1382, tyrphostin.AG.1478, BMS.599626",0.0114410431213845,0,FALSE +"HCC95","Pearson.est","Abl kinase inhibitor",-0.27828,-0.684,0.838,1301,0.987,"imatinib, tozasertib",0.0767559813697235,0.00568284733036327,FALSE +"HCC95","Pearson.est","acetylcholine receptor agonist",0.49968,1.37,0.144,5,0.47,"xanomeline",0.84163750790475,0.327902142064283,FALSE +"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.52214,-1.27,0.203,1096,0.722,"hyoscyamine, darifenacin, diphemanil",0.692503962086787,0.141462802430361,FALSE +"HCC95","Pearson.est","adenosine receptor antagonist",0.4387,1.21,0.228,55,0.668,"MRS.1220",0.642065152999546,0.175223537524454,FALSE +"HCC95","Pearson.est","adrenergic receptor agonist",-0.39216,-0.956,0.509,1162,0.826,"clenbuterol, methyldopa, buphenine, terbutaline, metaraminol, epinephrine",0.293282217663241,0.0830199526796178,FALSE +"HCC95","Pearson.est","adrenergic receptor antagonist",-0.27303,-0.677,0.844,1091,0.978,"levobunolol, imiloxan, dihydroergocristine, dronedarone, propranolol, vincamine",0.073657553374345,0.00966114521239857,FALSE +"HCC95","Pearson.est","AKT inhibitor",-0.47681,-1.19,0.269,1342,0.827,"ONC201, triciribine, uprosertib",0.570247719997592,0.0824944904474534,FALSE +"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.45458,-1.12,0.327,773,0.739,"SB.505124, DMH1, lorlatinib, brigatinib, AZD3463, CEP.37440, crizotinib, GW.788388",0.485452247339714,0.131355561605174,FALSE +"HCC95","Pearson.est","androgen receptor antagonist",-0.59334,-1.47,0.082,1140,0.826,"enzalutamide, cyproterone.acetate, bicalutamide",1.08618614761628,0.0830199526796178,FALSE +"HCC95","Pearson.est","antioxidant",0.38781,1.04,0.4,202,0.763,"trolox, benfotiamine",0.397940008672038,0.11747546204512,FALSE +"HCC95","Pearson.est","AP inhibitor",0.3667,1.02,0.415,2,0.731,"idronoxil",0.381951903287907,0.13608262304214,FALSE +"HCC95","Pearson.est","ATPase inhibitor",0.69862,1.91,0.0199,213,0.293,"k.strophanthidin, blebbistatin...., NMS.873, evodiamine, digitoxigenin, ouabain",1.70114692359029,0.533132379645891,FALSE +"HCC95","Pearson.est","Aurora kinase inhibitor",-0.28191,-0.676,0.842,1219,0.962,"barasertib, hesperadin, MLN.8054, PF.03814735, tozasertib",0.0746879085003505,0.0168249279621871,FALSE +"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.42666,-1.04,0.418,964,0.79,"dirithromycin, valnemulin, tedizolid, azalomycin.b, azithromycin",0.378823718224965,0.102372908709559,FALSE +"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",-0.43578,-1.08,0.377,1361,0.806,"lomefloxacin, novobiocin",0.423658649794207,0.0936649581949093,FALSE +"HCC95","Pearson.est","BCL inhibitor",0.29661,0.834,0.67,217,0.912,"ABT.737, gossypol, TW.37",0.173925197299174,0.0400051616715838,FALSE +"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.34726,-0.849,0.635,1301,0.871,"imatinib, tozasertib",0.197226274708024,0.0599818449923368,FALSE +"HCC95","Pearson.est","benzodiazepine receptor agonist",-0.30379,-0.748,0.762,940,0.94,"CL.218872, lorazepam, bentazepam, ivermectin, eprinomectin, zaleplon",0.1180450286604,0.0268721464003014,FALSE +"HCC95","Pearson.est","bromodomain inhibitor",0.53235,1.45,0.116,267,0.423,"PFI.1, OTX015, bromosporine",0.935542010773082,0.373659632624958,FALSE +"HCC95","Pearson.est","calcium channel blocker",-0.26099,-0.637,0.882,1419,0.985,"penfluridol",0.0545314148681803,0.00656376950238827,FALSE +"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.54634,-1.34,0.159,994,0.832,"MK.0812, ZK811752, RS.504393, PF.04136309, navarixin",0.798602875679548,0.0798766737092761,FALSE +"HCC95","Pearson.est","CDK inhibitor",-0.35431,-0.871,0.606,1063,0.869,"BMS.265246, JNJ.7706621, BMS.387032, indisulam, R547, alvocidib, AZD5438, PHA.793887",0.217527375833714,0.0609802235513335,FALSE +"HCC95","Pearson.est","CHK inhibitor",-0.58405,-1.43,0.0891,918,0.757,"PF.477736, LY2606368, SB.218078, LY2603618, CHIR.124, SCH.900776",1.05012229596313,0.120904120499927,FALSE +"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.46292,-1.15,0.28,1113,0.752,"phenazone, acetylsalicylsalicylic.acid, indoprofen, ramifenazone, FK.3311, curcumin, aspirin, amfenac, meloxicam",0.552841968657781,0.123782159408358,FALSE +"HCC95","Pearson.est","cytochrome P450 inhibitor",0.39374,1.11,0.292,247,0.781,"morin, eplerenone, metyrapone, itraconazole",0.534617148551582,0.1073489661227,FALSE +"HCC95","Pearson.est","DNA alkylating agent",-0.51026,-1.25,0.204,1157,0.739,"carboplatin, dianhydrogalactitol, melphalan, cyclophosphamide, mitomycin.c, dacarbazine",0.690369832574101,0.131355561605174,FALSE +"HCC95","Pearson.est","DNA inhibitor",-0.62402,-1.54,0.052,1157,0.845,"carboplatin, valrubicin, melphalan, tirapazamine, sangivamycin, nimorazole, busulfan, nithiamide",1.2839966563652,0.0731432910503077,FALSE +"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.51536,-1.27,0.193,1313,0.722,"fdcyd, azacitidine",0.714442690992226,0.141462802430361,FALSE +"HCC95","Pearson.est","DNA polymerase inhibitor",-0.35947,-0.878,0.611,1065,0.875,"idoxuridine, famciclovir, trifluridine, foscarnet",0.213958789757446,0.0579919469776868,FALSE +"HCC95","Pearson.est","DNA synthesis inhibitor",-0.38385,-0.939,0.553,1109,0.84,"CB.10.277, cyclocytidine, enocitabine, mitomycin.c, floxuridine, altretamine",0.257274868695302,0.0757207139381184,FALSE +"HCC95","Pearson.est","dopamine receptor antagonist",-0.54394,-1.3,0.171,1266,0.833,"domperidone, isofloxythepin, lurasidone, amisulpride, oxiperomide",0.767003889607846,0.0793549985932124,FALSE +"HCC95","Pearson.est","estrogen receptor agonist",-0.46089,-1.15,0.29,1341,0.752,"equol, PPT",0.537602002101044,0.123782159408358,FALSE +"HCC95","Pearson.est","estrogen receptor antagonist",-0.23461,-0.57,0.944,734,1,"tamoxifen, danazol, clomifene, raloxifene",0.025028005701931,0,FALSE +"HCC95","Pearson.est","FGFR inhibitor",0.2886,0.826,0.638,1033,0.866,"erdafitinib, PD.173074, orantinib, nintedanib, MK.2461, dovitinib, regorafenib, AZD4547, lenvatinib, lucitanib",0.195179321278838,0.0624821079826534,FALSE +"HCC95","Pearson.est","FLT3 inhibitor",-0.41208,-1.02,0.418,1283,0.785,"sunitinib, tozasertib, pacritinib, tandutinib",0.378823718224965,0.105130343254747,FALSE +"HCC95","Pearson.est","glucocorticoid receptor agonist",0.58663,1.63,0.0502,234,0.532,"deflazacort, prednisolone.hemisuccinate, flumethasone.pivalate, triamcinolone.acetonide, beclomethasone.dipropionate, triamcinolone, dexamethasone.acetate, desonide, ciclesonide, betamethasone, fluocinolone.acetonide, rimexolone, halcinonide, piretanide",1.29929628285498,0.274088367704952,FALSE +"HCC95","Pearson.est","glutamate receptor antagonist",-0.41429,-0.999,0.463,1128,0.784,"SIB.1757, tiletamine, latrepirdine, CPP, diazooxonorleucine",0.334419008982047,0.105683937315562,FALSE +"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.20222,0.563,0.95,1157,1,"indirubin, TWS.119, CHIR.99021, GSK.3.inhibitor.IX, LY2090314, kenpaullone, tideglusib, CHIR.98014, AZD2858",0.0222763947111523,0,FALSE +"HCC95","Pearson.est","growth factor receptor inhibitor",-0.33695,-0.824,0.676,1015,0.875,"AZD3463, GW.441756, GSK1838705A",0.170053304058364,0.0579919469776868,FALSE +"HCC95","Pearson.est","HCV inhibitor",-0.59201,-1.44,0.0858,1150,0.823,"PSI.7976, embelin, Ro.9187, daclatasvir",1.06651271215129,0.0846001647877302,FALSE +"HCC95","Pearson.est","HDAC inhibitor",-0.24604,-0.611,0.913,1018,0.993,"chidamide, romidepsin, M.344, dacinostat, tacedinaline, SB.939, JNJ.26481585, vorinostat",0.039529222465701,0.00305075150461883,FALSE +"HCC95","Pearson.est","histamine receptor antagonist",-0.3985,-0.98,0.483,1012,0.8,"tecastemizole, nizatidine, astemizole, levocetirizine, tiotidine, terfenadine, chloropyramine, zolantidine",0.316052869248488,0.0969100130080564,FALSE +"HCC95","Pearson.est","HMGCR inhibitor",0.25312,0.699,0.836,1083,0.969,"lovastatin, pitavastatin, atorvastatin, fluvastatin, simvastatin, mevastatin",0.0777937225609836,0.0136762229492347,FALSE +"HCC95","Pearson.est","HSP inhibitor",-0.21365,-0.522,0.963,768,1,"SNX.2112, tanespimycin, BIIB021, NVP.AUY922, guanidine, PU.H71, VER.49009",0.0163737128754655,0,FALSE +"HCC95","Pearson.est","JAK inhibitor",-0.41458,-1.04,0.429,1378,0.79,"atiprimod, LY2784544, tozasertib, pacritinib",0.367542707815276,0.102372908709559,FALSE +"HCC95","Pearson.est","KIT inhibitor",-0.34217,-0.842,0.652,1283,0.865,"sunitinib, imatinib, tandutinib",0.18575240426808,0.0629838925351858,FALSE +"HCC95","Pearson.est","MDM inhibitor",-0.32242,-0.79,0.715,685,0.894,"RITA, CGM097, idasanutlin, nutlin.3",0.145693958198919,0.0486624812040823,FALSE +"HCC95","Pearson.est","MEK inhibitor",-0.56398,-1.4,0.104,1085,0.777,"TAK.733, arctigenin, PD.198306, Ro.4987655, nobiletin, AS.703026, BIX.02188, cobimetinib, MEK162, PD.98059, trametinib, PD.0325901",0.98296666070122,0.109578981199086,FALSE +"HCC95","Pearson.est","MET inhibitor",-0.65095,-1.58,0.0374,976,1,"LY2801653, NVP.BVU972, INC.280, PF.04217903, AMG458",1.42712839779952,0,FALSE +"HCC95","Pearson.est","microtubule inhibitor",0.2427,0.69,0.814,1099,0.927,"cytochalasin.b, estramustine.phosphate, cabazitaxel, vinblastine, colchicine, podophyllotoxin, secnidazole, triclabendazole, D.64131, vinflunine",0.0893755951107988,0.0329202658555029,FALSE +"HCC95","Pearson.est","mTOR inhibitor",-0.42542,-1.04,0.439,1118,0.79,"NVP.BEZ235, GSK2126458, AZD8055, PP242, LY303511, GDC.0980, ku.0063794, sirolimus, PI.103",0.357535479757879,0.102372908709559,FALSE +"HCC95","Pearson.est","NFkB pathway inhibitor",-0.34895,-0.853,0.66,1199,0.883,"parthenolide...., betulinic.acid, curcumin, bortezomib",0.180456064458131,0.0540392964224314,FALSE +"HCC95","Pearson.est","opioid receptor agonist",-0.42807,-1.05,0.405,1194,0.847,"BW.180C, salvinorin.a",0.392544976785331,0.0721165896692931,FALSE +"HCC95","Pearson.est","p38 MAPK inhibitor",-0.6211,-1.5,0.0658,895,0.845,"CMPD.1, SB.239063, talmapimod, skepinone.l, SB.242235, VX.702, TAK.715",1.18177410638604,0.0731432910503077,FALSE +"HCC95","Pearson.est","PARP inhibitor",-0.4096,-1,0.476,1207,0.803,"PJ.34, olaparib, niraparib",0.322393047279507,0.095284454721319,FALSE +"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.37793,-0.921,0.557,1283,0.835,"sunitinib, imatinib, trapidil, tandutinib",0.254144804826271,0.0783135245163979,FALSE +"HCC95","Pearson.est","phosphatase inhibitor",0.56844,1.59,0.0802,156,0.418,"GSK2830371, menadione, CID.5458317, bis.maltolato.oxovanadium.IV.",1.09582563171584,0.378823718224965,FALSE +"HCC95","Pearson.est","phosphodiesterase inhibitor",0.27929,0.79,0.692,9,0.876,"avanafil",0.159893905543242,0.0574958938319193,FALSE +"HCC95","Pearson.est","PI3K inhibitor",-0.38503,-0.931,0.545,1118,0.836,"NVP.BEZ235, GSK2126458, pilaralisib, alpelisib, taselisib, LY303511, GDC.0980, PI.103, TG.100713, CH5132799",0.263603497723358,0.0777937225609836,FALSE +"HCC95","Pearson.est","PLK inhibitor",-0.46842,-1.16,0.304,921,0.793,"NMS.1286937, GW.843682X, GSK461364, BI.2536",0.517126416391246,0.100726812682396,FALSE +"HCC95","Pearson.est","potassium channel blocker",-0.54978,-1.36,0.148,1202,0.837,"meglitinide, oleoylethanolamide",0.829738284605043,0.07727454200674,FALSE +"HCC95","Pearson.est","PPAR receptor agonist",0.30971,0.864,0.591,143,0.92,"pterostilbene, fenofibrate",0.228412519118745,0.0362121726544447,FALSE +"HCC95","Pearson.est","progesterone receptor agonist",0.52377,1.45,0.109,68,0.423,"norethindrone, tanaproget",0.962573502059376,0.373659632624958,FALSE +"HCC95","Pearson.est","proteasome inhibitor",-0.63877,-1.57,0.0576,946,0.942,"ixazomib.citrate, MG.132, ONX.0914, delanzomib, ixazomib, carfilzomib, bortezomib",1.23957751657679,0.0259490972071227,FALSE +"HCC95","Pearson.est","protein synthesis inhibitor",0.19637,0.537,0.974,1167,0.968,"clindamycin.phosphate, methacycline, clofoctol, azomycin..2.nitroimidazole., chloramphenicol.palmitate, cycloheximide, harringtonine, anguidine, florfenicol, emetine, tedizolid.phosphate, mercaptopurine, thiostrepton, bruceantin, puromycin, brefeldin.a, homoharringtonine",0.0114410431213845,0.0141246426916063,FALSE +"HCC95","Pearson.est","protein tyrosine kinase inhibitor",0.39364,1.09,0.345,52,0.734,"PP.121, mubritinib",0.462180904926726,0.134303940083929,FALSE +"HCC95","Pearson.est","RAF inhibitor",-0.47975,-1.18,0.255,1101,0.812,"LGX818, SB.590885, CEP.32496, vemurafenib, dabrafenib, AZ.628",0.593459819566045,0.0904439707588247,FALSE +"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.51892,-1.27,0.188,1283,0.722,"sunitinib, apatinib",0.72584215073632,0.141462802430361,FALSE +"HCC95","Pearson.est","retinoid receptor agonist",-0.33142,-0.816,0.697,986,0.871,"adapalene, bexarotene, tamibarotene, AM.580, CD.437",0.156767221901991,0.0599818449923368,FALSE +"HCC95","Pearson.est","ribonucleotide reductase inhibitor",-0.45344,-1.12,0.33,887,0.739,"cladribine, LY2334737, clofarabine, fludarabine, fludarabine.phosphate",0.481486060122112,0.131355561605174,FALSE +"HCC95","Pearson.est","serotonin receptor agonist",-0.5081,-1.24,0.202,1090,0.726,"zolmitriptan, aripiprazole",0.694648630553376,0.139063379299906,FALSE +"HCC95","Pearson.est","serotonin receptor antagonist",-0.47447,-1.17,0.296,1264,0.803,"SB.216641, lurasidone, aripiprazole, RS.16566",0.528708288941061,0.095284454721319,FALSE +"HCC95","Pearson.est","sodium channel blocker",-0.35591,-0.881,0.588,1138,0.89,"triamterene, brivaracetam, butamben, lappaconite, ajmaline",0.230622673923862,0.0506099933550872,FALSE +"HCC95","Pearson.est","src inhibitor",0.32758,0.877,0.559,122,0.967,"ZM.306416, TG.100572, masitinib",0.252588192113577,0.0145735259169983,FALSE +"HCC95","Pearson.est","sterol demethylase inhibitor",-0.4165,-1.02,0.434,1235,0.785,"ketoconazole, lanoconazole",0.362510270487489,0.105130343254747,FALSE +"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.53143,-1.28,0.194,1176,0.84,"repsox, D.4476, LY2109761",0.712198270069774,0.0757207139381184,FALSE +"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.75859,-1.83,0.00577,1211,0.38,"trifluridine, raltitrexed, carmofur, doxifluridine",2.23882418684427,0.42021640338319,FALSE +"HCC95","Pearson.est","topoisomerase inhibitor",-0.46406,-1.12,0.313,825,0.739,"TAS.103, teniposide, dexrazoxane, beta.lapachone, etoposide, camptothecin, rubitecan, idarubicin, amonafide, valrubicin, SN.38, topotecan, amsacrine, irinotecan, licochalcone.a, genz.644282, exatecan.mesylate",0.504455662453552,0.131355561605174,FALSE +"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.14709,-0.358,1,588,1,"albendazole, vincristine, vinorelbine, flubendazole, docetaxel, taltobulin, ABT.751, BNC105, plinabulin, paclitaxel, fosbretabulin, podophyllotoxin, indibulin, combretastatin.A.4, epothilone.b, KX2.391, oxibendazole, mebendazole",0,0,FALSE +"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.2927,-0.715,0.809,1404,0.967,"apatinib, AMG.208, BMS.599626",0.0920514783877277,0.0145735259169983,FALSE +"HCC95","Pearson.est","VEGFR inhibitor",-0.14312,-0.348,0.999,858,0.999,"cabozantinib, vatalanib, ENMD.2076, linifanib, lenvatinib, lucitanib, OSI.930, golvatinib, foretinib, tivozanib, MGCD.265, AEE788, sunitinib",0.000434511774017692,0.000434511774017692,FALSE +"HCC95","Pearson.est","vitamin D receptor agonist",-0.53272,-1.31,0.154,1397,0.865,"maxacalcitol, ercalcitriol",0.812479279163537,0.0629838925351858,FALSE +"H1650","Pearson.est","EGFR inhibitor",-0.4296,-1.09,0.358,1059,0.931,"ARRY.334543, CNX.2006, gefitinib, tyrphostin.AG.494, WZ.4002, canertinib, OSI.420, afatinib, TAK.285, BMS.599626, osimertinib, PD.153035, BIBX.1382, icotinib, tyrphostin.AG.1478, rociletinib, pelitinib, vandetanib, erlotinib, PD.168393, BIBU.1361, WZ8040",0.446116973356126,0.0310503190186574,FALSE +"H1650","Pearson.est","Abl kinase inhibitor",0.31755,0.87,0.576,992,0.891,"GZD824, KW.2449, ponatinib, imatinib, bafetinib, tozasertib, dasatinib, metatinib, flumatinib, bosutinib, ZM.306416, nilotinib",0.239577516576788,0.0501222959631252,FALSE +"H1650","Pearson.est","acetylcholine receptor agonist",0.5632,1.5,0.0845,58,0.525,"xanomeline",1.07314329105031,0.279840696594043,FALSE +"H1650","Pearson.est","acetylcholine receptor antagonist",-0.38766,-0.949,0.526,1001,0.893,"darifenacin, iododexetimide, diphemanil",0.279014255846261,0.0491485411114536,FALSE +"H1650","Pearson.est","adenosine receptor antagonist",-0.32628,-0.801,0.704,1217,0.889,"sulmazole, istradefylline",0.152427340857888,0.0510982390297863,FALSE +"H1650","Pearson.est","adrenergic receptor agonist",-0.38321,-0.941,0.527,1040,0.877,"methyldopa, xylazine, isoxsuprine, oxymetazoline, epinephrine, isoetharine",0.278189384787453,0.0570004066339595,FALSE +"H1650","Pearson.est","adrenergic receptor antagonist",0.37604,1.01,0.425,189,0.881,"atenolol......, dihydroergocristine, idazoxan, naftidrofuryl",0.371611069949688,0.0550240915879521,FALSE +"H1650","Pearson.est","AKT inhibitor",-0.34247,-0.844,0.667,908,0.892,"MK.2206, triciribine, GSK2110183, palomid.529, AZD5363, CCT128930, AT7867",0.175874166083451,0.0496351456238769,FALSE +"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.23664,0.644,0.891,326,0.934,"DMH1, SB.505124, brigatinib, CEP.37440, crizotinib",0.0501222959631252,0.0296531237699066,FALSE +"H1650","Pearson.est","androgen receptor antagonist",-0.26332,-0.662,0.865,1261,0.989,"RU.58841",0.0629838925351858,0.0048037084028206,FALSE +"H1650","Pearson.est","antioxidant",-0.40221,-0.977,0.489,1063,0.868,"benfotiamine, mesna, rutin",0.31069114087638,0.0614802748235081,FALSE +"H1650","Pearson.est","AP inhibitor",-0.63364,-1.58,0.0425,1330,0.458,"embelin, tanshinone.i, GDC.0152",1.37161106994969,0.339134521996131,FALSE +"H1650","Pearson.est","ATPase inhibitor",0.6778,1.85,0.0213,31,0.328,"k.strophanthidin, evodiamine, NMS.873, digoxin",1.67162039656126,0.484126156288321,FALSE +"H1650","Pearson.est","Aurora kinase inhibitor",0.31919,0.848,0.595,395,0.832,"CCT137690, CCT129202, PHA.680632, danusertib, barasertib.HQPA, aurora.a.inhibitor.i, AMG900, barasertib, KW.2449, SNS.314, PF.03814735",0.22548303427145,0.0798766737092761,FALSE +"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.26042,0.687,0.83,1073,0.936,"josamycin, azalomycin.b, azithromycin, valnemulin, dirithromycin, tilmicosin, tedizolid, radezolid",0.0809219076239261,0.0287241512618947,FALSE +"H1650","Pearson.est","bacterial DNA gyrase inhibitor",-0.26726,-0.658,0.879,881,0.97,"sarafloxacin, trovafloxacin, novobiocin, finafloxacin",0.0560111249262281,0.0132282657337552,FALSE +"H1650","Pearson.est","BCL inhibitor",0.51987,1.41,0.0912,337,0.481,"venetoclax, gossypol, TW.37, oridonin",1.04000516167158,0.317854923626168,FALSE +"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.31711,0.874,0.61,992,0.922,"GZD824, ponatinib, imatinib, bafetinib, tozasertib, dasatinib, metatinib, flumatinib, bosutinib, nilotinib",0.214670164989233,0.0352690789463706,FALSE +"H1650","Pearson.est","benzodiazepine receptor agonist",-0.18794,-0.463,0.99,1041,0.988,"zaleplon, CGS.20625, lorazepam",0.00436480540245009,0.00524305541237188,FALSE +"H1650","Pearson.est","bromodomain inhibitor",0.43823,1.17,0.256,167,0.801,"I.BET.762, PFI.1",0.59176003468815,0.0963674839157623,FALSE +"H1650","Pearson.est","calcium channel blocker",0.26762,0.722,0.78,136,0.982,"carboxyamidotriazole, SKF.96365",0.10790539730952,0.00788851221305034,FALSE +"H1650","Pearson.est","CC chemokine receptor antagonist",-0.43071,-1.06,0.385,1203,0.909,"MK.0812, RS.504393, navarixin",0.414539270491499,0.0414361167780325,FALSE +"H1650","Pearson.est","CDK inhibitor",0.45584,1.2,0.252,276,0.798,"PHA.848125, dinaciclib, indisulam, abemaciclib, AT.7519, BMS.387032, JNJ.7706621, alvocidib",0.598599459218456,0.0979971086492706,FALSE +"H1650","Pearson.est","CHK inhibitor",-0.41457,-1.04,0.409,939,0.834,"LY2606368, CHIR.124, SCH.900776, AZD7762",0.388276691992658,0.0788339493622613,FALSE +"H1650","Pearson.est","cyclooxygenase inhibitor",-0.41549,-1.06,0.408,912,0.909,"AM.404, suxibuzone, meloxicam, ketoprofen, piroxicam, amfenac, acetylsalicylsalicylic.acid, curcumin, tryptanthrin, indoprofen, FR.122047, pterostilbene, metoxibutropate, naproxen",0.38933983691012,0.0414361167780325,FALSE +"H1650","Pearson.est","cytochrome P450 inhibitor",-0.43393,-1.1,0.336,1243,0.957,"cobicistat, itraconazole",0.473660722610156,0.0190880622231565,FALSE +"H1650","Pearson.est","DNA alkylating agent",0.34742,0.956,0.483,223,0.913,"carmustine, estramustine, satraplatin, mitomycin.c",0.316052869248488,0.039529222465701,FALSE +"H1650","Pearson.est","DNA inhibitor",0.32268,0.887,0.593,359,0.934,"carmustine, mechlorethamine, sangivamycin, chlorambucil, bendamustine, pibenzimol, teroxirone, carboplatin",0.226945306635737,0.0296531237699066,FALSE +"H1650","Pearson.est","DNA methyltransferase inhibitor",-0.36309,-0.92,0.562,1245,0.888,"RG108, azacitidine",0.250263684430939,0.051587034221399,FALSE +"H1650","Pearson.est","DNA polymerase inhibitor",-0.48076,-1.22,0.241,1163,0.794,"adefovir.dipivoxil, cephalomannine, cidofovir",0.617982957425132,0.100179497572904,FALSE +"H1650","Pearson.est","DNA synthesis inhibitor",-0.3177,-0.801,0.71,1375,0.889,"estramustine.phosphate, CB.10.277",0.148741651280925,0.0510982390297863,FALSE +"H1650","Pearson.est","dopamine receptor antagonist",-0.54953,-1.37,0.143,993,0.578,"UH.232...., clebopride, domperidone, ziprasidone, amisulpride, raclopride, mesoridazine, acetophenazine, nemonapride, oxiperomide, remoxipride",0.844663962534938,0.238072161579471,FALSE +"H1650","Pearson.est","estrogen receptor agonist",-0.22929,-0.571,0.946,885,1,"ethinyl.estradiol, estrone, estradiol, PPT",0.0241088635982073,0,FALSE +"H1650","Pearson.est","estrogen receptor antagonist",-0.47148,-1.18,0.248,1141,0.846,"raloxifene, fulvestrant",0.605548319173784,0.0726296369609765,FALSE +"H1650","Pearson.est","FGFR inhibitor",0.56166,1.54,0.0829,100,0.537,"dovitinib, nintedanib, regorafenib, erdafitinib, lenvatinib",1.08144546944973,0.270025714300444,FALSE +"H1650","Pearson.est","FLT3 inhibitor",0.28322,0.744,0.738,419,0.981,"dovitinib, tyrphostin.AG.1296, sorafenib, TG.101348, KW.2449, ponatinib, gilteritinib",0.131943638176958,0.0083309926200515,FALSE +"H1650","Pearson.est","glucocorticoid receptor agonist",-0.28658,-0.724,0.793,1003,0.957,"triamcinolone, piretanide, clobetasol.propionate, triamcinolone.acetonide, rimexolone, difluprednate, flumethasone.pivalate, dexamethasone.acetate, fludroxycortide, prednisolone.acetate",0.100726812682396,0.0190880622231565,FALSE +"H1650","Pearson.est","glutamate receptor antagonist",-0.35394,-0.877,0.61,1084,0.885,"CPP, ACDPP, MTPG, latrepirdine, SIB.1757",0.214670164989233,0.0530567293021746,FALSE +"H1650","Pearson.est","glycogen synthase kinase inhibitor",-0.53927,-1.32,0.181,1312,0.65,"kenpaullone, LY2090314",0.742321425130815,0.187086643357144,FALSE +"H1650","Pearson.est","growth factor receptor inhibitor",0.68522,1.8,0.0225,196,0.294,"PHA.848125, GSK1838705A, danusertib",1.64781748188864,0.531652669587843,FALSE +"H1650","Pearson.est","HCV inhibitor",-0.75819,-1.9,0.0116,1257,0.103,"Ro.9187, PSI.7976, narlaprevir, embelin",1.93554201077308,0.987162775294828,TRUE +"H1650","Pearson.est","HDAC inhibitor",-0.51695,-1.29,0.193,1160,0.675,"SB.939, nexturastat.a, mocetinostat, ACY.1215, tacedinaline, RGFP966, romidepsin, entinostat, JNJ.26481585, RG2833",0.714442690992226,0.170696227168975,FALSE +"H1650","Pearson.est","histamine receptor antagonist",-0.57126,-1.41,0.107,1105,0.538,"levocetirizine, ranitidine, cimetidine, famotidine, BF2.649, tiotidine, lafutidine, ICI.162846, tecastemizole, chloropyramine",0.97061622231479,0.269217724333611,FALSE +"H1650","Pearson.est","HMGCR inhibitor",-0.81207,-2.04,0,1171,0.0314,"lovastatin, mevastatin, atorvastatin, fluvastatin, pitavastatin, simvastatin",Inf,1.50307035192679,TRUE +"H1650","Pearson.est","HSP inhibitor",-0.39689,-1,0.442,804,0.886,"alvespimycin, SNX.2112, PU.H71, BIIB021, NVP.AUY922, XL888, KW.2478, VER.49009, guanidine",0.354577730650908,0.0525662781129492,FALSE +"H1650","Pearson.est","JAK inhibitor",-0.3407,-0.85,0.647,1128,0.908,"LY2784544, PRT062070, pacritinib, atiprimod",0.1890957193313,0.0419141514789149,FALSE +"H1650","Pearson.est","KIT inhibitor",-0.31773,-0.788,0.715,1333,0.886,"vatalanib, midostaurin, telatinib",0.145693958198919,0.0525662781129492,FALSE +"H1650","Pearson.est","MDM inhibitor",-0.65951,-1.66,0.0323,1317,0.349,"CGM097, RITA",1.4907974776689,0.45717457304082,FALSE +"H1650","Pearson.est","MEK inhibitor",-0.58635,-1.45,0.0864,1026,0.559,"refametinib, PD.0325901, PD.198306, BIX.02188, MEK162, U.0126, PD.318088, Ro.4987655, AZD8330, PD.184352, TAK.733",1.06348625752111,0.252588192113577,FALSE +"H1650","Pearson.est","MET inhibitor",-0.29779,-0.723,0.807,1179,0.935,"PF.04217903",0.0931264652779296,0.0291883891274822,FALSE +"H1650","Pearson.est","microtubule inhibitor",0.39967,1.08,0.359,207,0.895,"D.64131, vinblastine, vinflunine, cytochalasin.b",0.444905551421681,0.048176964684088,FALSE +"H1650","Pearson.est","mTOR inhibitor",-0.22222,-0.56,0.95,1264,0.989,"deforolimus, torin.2, PF.05212384, sirolimus",0.0222763947111523,0.0048037084028206,FALSE +"H1650","Pearson.est","NFkB pathway inhibitor",-0.43579,-1.05,0.382,1144,0.849,"Ro.106.9920, bortezomib, curcumin, parthenolide...., BAY.11.7085",0.417936637088291,0.0710923097560473,FALSE +"H1650","Pearson.est","opioid receptor agonist",-0.35756,-0.881,0.592,1295,0.936,"ADL5859",0.22767829327708,0.0287241512618947,FALSE +"H1650","Pearson.est","p38 MAPK inhibitor",0.34647,0.923,0.514,5,0.896,"talmapimod",0.289036881004724,0.0476919903378748,FALSE +"H1650","Pearson.est","PARP inhibitor",-0.3212,-0.806,0.699,1227,0.931,"AZD2461, E7449",0.155522824254319,0.0310503190186574,FALSE +"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.3191,0.855,0.608,117,0.884,"dovitinib, nintedanib, regorafenib, lenvatinib, pazopanib",0.216096420727265,0.0535477349869269,FALSE +"H1650","Pearson.est","phosphatase inhibitor",0.32165,0.853,0.604,318,0.854,"sodium.stibogluconate, GSK2830371, AS.1949490, mycophenolic.acid, CID.5458317",0.218963061378868,0.068542129310995,FALSE +"H1650","Pearson.est","phosphodiesterase inhibitor",-0.42356,-1.05,0.393,1369,0.849,"GSK256066, papaverine",0.405607449624573,0.0710923097560473,FALSE +"H1650","Pearson.est","PI3K inhibitor",0.21643,0.58,0.925,78,0.94,"idelalisib, buparlisib, alpelisib",0.0338582672609674,0.0268721464003014,FALSE +"H1650","Pearson.est","PLK inhibitor",0.77241,2.1,0.00279,261,0.108,"volasertib, NMS.1286937, GW.843682X, BI.2536, HMN.214, rigosertib",2.5543957967264,0.96657624451305,TRUE +"H1650","Pearson.est","potassium channel blocker",-0.59317,-1.52,0.0595,1114,0.536,"mepivacaine, oleoylethanolamide, meglitinide",1.22548303427145,0.27083521030723,FALSE +"H1650","Pearson.est","PPAR receptor agonist",-0.73323,-1.85,0.0111,1188,0.112,"fenofibrate, S26948, oleoylethanolamide, GW.501516, pterostilbene",1.95467702121334,0.950781977329818,TRUE +"H1650","Pearson.est","progesterone receptor agonist",-0.22562,-0.559,0.946,1125,0.968,"melengestrol.acetate, norgestrel",0.0241088635982073,0.0141246426916063,FALSE +"H1650","Pearson.est","proteasome inhibitor",-0.58154,-1.46,0.0997,956,0.613,"carfilzomib, delanzomib, ixazomib, bortezomib, oprozomib, ixazomib.citrate, ONX.0914",1.00130484168834,0.212539525481585,FALSE +"H1650","Pearson.est","protein synthesis inhibitor",0.54499,1.47,0.0885,320,0.437,"clofoctol, harringtonine, homoharringtonine, tedizolid.phosphate, anguidine, bruceantin, thiostrepton, puromycin, chloramphenicol.palmitate",1.05305672930217,0.359518563029578,FALSE +"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.4011,1.06,0.4,265,0.825,"PP.121, mubritinib, CP.724714, tyrphostin.A9",0.397940008672038,0.0835460514500749,FALSE +"H1650","Pearson.est","RAF inhibitor",0.39571,1.07,0.357,52,0.858,"SB.590885, regorafenib",0.447331783887807,0.0665127121512946,FALSE +"H1650","Pearson.est","RET tyrosine kinase inhibitor",-0.39502,-0.999,0.459,1294,0.853,"apatinib, vandetanib",0.338187314462739,0.069050968832477,FALSE +"H1650","Pearson.est","retinoid receptor agonist",0.61039,1.7,0.0397,286,0.356,"adarotene, fenretinide, adapalene, tamibarotene",1.40120949323689,0.448550002027125,FALSE +"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.36092,0.97,0.478,342,0.927,"pentostatin, cytarabine, hydroxyurea, cladribine",0.320572103387881,0.0329202658555029,FALSE +"H1650","Pearson.est","serotonin receptor agonist",0.41019,1.09,0.346,98,0.936,"zolmitriptan, pardoprunox",0.460923901207223,0.0287241512618947,FALSE +"H1650","Pearson.est","serotonin receptor antagonist",0.24963,0.661,0.869,65,0.942,"SB.200646, pirenperone",0.0609802235513335,0.0259490972071227,FALSE +"H1650","Pearson.est","sodium channel blocker",-0.35429,-0.878,0.586,1114,0.912,"mepivacaine, mexiletine, A.803467, quinidine",0.232102383981909,0.0400051616715838,FALSE +"H1650","Pearson.est","src inhibitor",0.26129,0.693,0.779,1072,0.958,"masitinib, KX2.391, saracatinib, TG.100572, dasatinib, PP.1, bosutinib, ZM.306416, PP.2",0.108462542327436,0.0186344909214556,FALSE +"H1650","Pearson.est","sterol demethylase inhibitor",0.26418,0.716,0.824,348,0.957,"chlormidazole, sulconazole, posaconazole",0.0840727883028842,0.0190880622231565,FALSE +"H1650","Pearson.est","TGF beta receptor inhibitor",-0.451,-1.11,0.339,739,0.988,"LY2109761, SB.525334, repsox, SB.431542, D.4476",0.469800301796918,0.00524305541237188,FALSE +"H1650","Pearson.est","thymidylate synthase inhibitor",0.50597,1.36,0.14,563,0.515,"ftorafur, carmofur, raltitrexed, doxifluridine, capecitabine",0.853871964321762,0.288192770958809,FALSE +"H1650","Pearson.est","topoisomerase inhibitor",-0.22785,-0.567,0.945,1039,1,"licochalcone.a, idarubicin, TAS.103, rubitecan, fleroxacin, teniposide, voreloxin, beta.lapachone, etoposide, camptothecin",0.0245681914907371,0,FALSE +"H1650","Pearson.est","tubulin polymerization inhibitor",0.56765,1.48,0.101,388,0.482,"vindesine, oxibendazole, fenbendazole, vinblastine, docetaxel, paclitaxel, verubulin, vinorelbine, ABT.751, fosbretabulin, BNC105, taltobulin, nocodazole, vincristine, dolastatin.10, epothilone.b, KX2.391, parbendazole",0.995678626217357,0.31695296176115,FALSE +"H1650","Pearson.est","tyrosine kinase inhibitor",0.34914,0.945,0.495,62,0.891,"PP.121, tivantinib, regorafenib, mubritinib",0.305394801066431,0.0501222959631252,FALSE +"H1650","Pearson.est","VEGFR inhibitor",0.2377,0.632,0.891,117,0.919,"dovitinib, nintedanib, regorafenib, SAR131675, lenvatinib, pazopanib",0.0501222959631252,0.0366844886138887,FALSE +"H1650","Pearson.est","vitamin D receptor agonist",-0.57285,-1.42,0.115,1006,0.574,"maxacalcitol, tacalcitol, calcitriol, paricalcitol, ercalcitriol",0.939302159646388,0.241088107602027,FALSE +"H1975","Pearson.est","EGFR inhibitor",0.38057,0.946,0.499,454,0.89,"neratinib, tucatinib, AEE788, CP.724714, lapatinib, GW.583340, dacomitinib, PD.153035, OSI.420, dovitinib, CUDC.101, afatinib, osimertinib, BMS.599626, TAK.285, canertinib, FERb.033, AZD8931",0.30189945437661,0.0506099933550872,FALSE +"H1975","Pearson.est","Abl kinase inhibitor",-0.72949,-1.96,0.00512,1349,0.0621,"flumatinib, GZD824, KW.2449, ponatinib, dasatinib",2.29073003902417,1.20690839982342,TRUE +"H1975","Pearson.est","acetylcholine receptor agonist",0.37242,0.937,0.527,301,0.88,"pilocarpine, tremorine, oxiracetam",0.278189384787453,0.0555173278498314,FALSE +"H1975","Pearson.est","acetylcholine receptor antagonist",0.69158,1.74,0.0169,333,0.216,"diphemanil, hyoscyamine, darifenacin, dicycloverine",1.77211329538633,0.665546248849069,TRUE +"H1975","Pearson.est","adenosine receptor antagonist",0.28586,0.715,0.794,270,0.922,"CGS.15943, PSB.1115",0.100179497572904,0.0352690789463706,FALSE +"H1975","Pearson.est","adrenergic receptor agonist",0.34629,0.879,0.596,68,0.868,"lidamidine, methyldopa",0.224753740259764,0.0614802748235081,FALSE +"H1975","Pearson.est","adrenergic receptor antagonist",0.37463,0.946,0.516,321,0.89,"RS.17053, prazosin, idazoxan, vincamine, carvedilol, levobunolol",0.287350298372789,0.0506099933550872,FALSE +"H1975","Pearson.est","AKT inhibitor",0.29526,0.744,0.775,166,0.901,"uprosertib, A.674563, triciribine",0.11069829749369,0.045275209020937,FALSE +"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.17783,-0.485,0.981,1098,0.984,"alectinib, brigatinib, lorlatinib, AP26113",0.0083309926200515,0.00700490156865849,FALSE +"H1975","Pearson.est","androgen receptor antagonist",0.57701,1.44,0.123,330,0.515,"cyproterone.acetate, enzalutamide, flutamide",0.910094888560602,0.288192770958809,FALSE +"H1975","Pearson.est","antioxidant",-0.76375,-2.05,0.00763,1378,0.112,"trolox, mesna, benfotiamine",2.11747546204512,0.950781977329818,TRUE +"H1975","Pearson.est","AP inhibitor",0.30287,0.778,0.722,387,0.888,"LCL.161, tanshinone.i",0.141462802430361,0.051587034221399,FALSE +"H1975","Pearson.est","ATPase inhibitor",-0.21223,-0.557,0.931,994,0.988,"rabeprazole, blebbistatin...., ouabain, k.strophanthidin, oligomycin.a",0.0310503190186574,0.00524305541237188,FALSE +"H1975","Pearson.est","Aurora kinase inhibitor",-0.58866,-1.59,0.0547,1229,0.305,"hesperadin, MK.8745, AMG900, barasertib, barasertib.HQPA, alisertib, KW.2449, SNS.314, GSK1070916, CYC116, AT.9283",1.26201267366657,0.515700160653214,FALSE +"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.52928,1.33,0.164,186,0.674,"azithromycin, azalomycin.b, dirithromycin",0.785156151952302,0.17134010346468,FALSE +"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.50608,-1.37,0.127,1376,0.377,"novobiocin, finafloxacin",0.896196279044043,0.423658649794207,FALSE +"H1975","Pearson.est","BCL inhibitor",-0.27361,-0.711,0.78,394,1,"obatoclax, HA14.1, oridonin, navitoclax, ABT.737, venetoclax, TW.37, gossypol",0.10790539730952,0,FALSE +"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.72181,-1.98,0.00964,1349,0.0711,"flumatinib, GZD824, ponatinib, dasatinib",2.01592296609717,1.14813039927023,TRUE +"H1975","Pearson.est","benzodiazepine receptor agonist",0.16954,0.42,0.998,206,0.995,"indiplon, zaleplon",0.000869458712628891,0.00217691925427455,FALSE +"H1975","Pearson.est","bromodomain inhibitor",0.35113,0.857,0.596,110,0.84,"JQ1....",0.224753740259764,0.0757207139381184,FALSE +"H1975","Pearson.est","calcium channel blocker",0.49553,1.24,0.225,359,0.711,"tetrandrine, fendiline, SKF.96365, cinnarazine",0.647817481888638,0.148130399270234,FALSE +"H1975","Pearson.est","CC chemokine receptor antagonist",0.50613,1.3,0.187,529,0.612,"PF.04136309, navarixin, RS.504393, ZK811752, MK.0812, SB.225002",0.728158393463501,0.213248577854439,FALSE +"H1975","Pearson.est","CDK inhibitor",0.39333,0.996,0.461,382,0.939,"BMS.387032, arcyriaflavin.a, JNJ.7706621, PHA.793887, AZD5438, dinaciclib, kenpaullone, CR8..R., BMS.265246, alvocidib",0.336299074610352,0.0273344077338891,FALSE +"H1975","Pearson.est","CHK inhibitor",0.66618,1.71,0.0312,105,0.218,"PF.477736, SB.218078, CHIR.124",1.50584540598156,0.661543506395395,TRUE +"H1975","Pearson.est","cyclooxygenase inhibitor",-0.25851,-0.67,0.831,1289,1,"sulfasalazine, ketoprofen, tepoxalin, metoxibutropate",0.080398976215889,0,FALSE +"H1975","Pearson.est","cytochrome P450 inhibitor",-0.5981,-1.58,0.0773,1206,0.273,"cobicistat, eplerenone, itraconazole",1.11182050608168,0.563837352959244,FALSE +"H1975","Pearson.est","DNA alkylating agent",0.43343,1.1,0.337,223,0.769,"dacarbazine, mitomycin.c, melphalan, ifosfamide, estramustine",0.472370099128661,0.114073660198569,FALSE +"H1975","Pearson.est","DNA inhibitor",0.3239,0.836,0.654,322,0.814,"melphalan, busulfan, metronidazole, primaquine, bendamustine",0.184422251675733,0.0893755951107988,FALSE +"H1975","Pearson.est","DNA methyltransferase inhibitor",0.6647,1.65,0.0351,184,0.272,"SGI.1027, azacitidine, fdcyd, disulfiram",1.45469288353418,0.565431095965801,FALSE +"H1975","Pearson.est","DNA polymerase inhibitor",0.23236,0.583,0.939,160,0.987,"trifluridine",0.0273344077338891,0.00568284733036327,FALSE +"H1975","Pearson.est","DNA synthesis inhibitor",0.33846,0.857,0.614,531,0.84,"mitomycin.c, enocitabine, floxuridine, capecitabine, nelarabine, cyclocytidine, anisomycin",0.211831628858832,0.0757207139381184,FALSE +"H1975","Pearson.est","dopamine receptor antagonist",0.25591,0.659,0.881,29,0.953,"sertindole, piperacetazine",0.0550240915879521,0.0209070993616736,FALSE +"H1975","Pearson.est","estrogen receptor agonist",-0.42284,-1.16,0.25,1089,0.613,"ethinyl.estradiol, estradiol, PPT, estrone",0.602059991327962,0.212539525481585,FALSE +"H1975","Pearson.est","estrogen receptor antagonist",0.65091,1.64,0.0248,312,0.252,"danazol, raloxifene, toremifene, clomifene",1.60554831917378,0.598599459218456,FALSE +"H1975","Pearson.est","FGFR inhibitor",0.51648,1.31,0.165,139,0.674,"regorafenib, lucitanib, lenvatinib",0.782516055786094,0.17134010346468,FALSE +"H1975","Pearson.est","FLT3 inhibitor",-0.28322,-0.766,0.729,1369,0.965,"KW.2449, ponatinib, midostaurin",0.137272471682025,0.0154726866562074,FALSE +"H1975","Pearson.est","glucocorticoid receptor agonist",-0.47209,-1.25,0.219,1177,0.508,"fluocinolone.acetonide, hydrocortisone, prednisolone.acetate, dexamethasone.acetate, desonide, prednisolone, beclomethasone.dipropionate, prednisolone.hemisuccinate, fluticasone.propionate, piretanide, triamcinolone",0.659555885159882,0.294136287716081,FALSE +"H1975","Pearson.est","glutamate receptor antagonist",0.41307,1.05,0.378,310,0.851,"CGP.37849, IEM1754, diazooxonorleucine, MTPG, CPP, ACDPP",0.422508200162775,0.0700704399154121,FALSE +"H1975","Pearson.est","glycogen synthase kinase inhibitor",0.24891,0.617,0.909,49,0.978,"AZD2858",0.0414361167780325,0.00966114521239857,FALSE +"H1975","Pearson.est","growth factor receptor inhibitor",0.39212,0.989,0.453,32,0.921,"GW.441756",0.343901797987168,0.0357403698031511,FALSE +"H1975","Pearson.est","HCV inhibitor",0.7096,1.76,0.017,98,0.235,"PSI.7976, daclatasvir",1.76955107862173,0.628932137728264,TRUE +"H1975","Pearson.est","HDAC inhibitor",-0.23229,-0.612,0.92,1419,0.978,"RG2833, mocetinostat",0.0362121726544447,0.00966114521239857,FALSE +"H1975","Pearson.est","histamine receptor antagonist",0.3871,0.966,0.497,218,0.938,"zolantidine, cyproheptadine, tecastemizole, astemizole, chloropyramine, nizatidine",0.303643611266668,0.0277971616209356,FALSE +"H1975","Pearson.est","HMGCR inhibitor",-0.74732,-1.98,0.0068,1216,0.0711,"lovastatin, atorvastatin, simvastatin, fluvastatin, pitavastatin",2.16749108729376,1.14813039927023,TRUE +"H1975","Pearson.est","HSP inhibitor",0.22138,0.569,0.952,345,0.978,"NMS.E973, SNX.2112, XL888",0.0213630516155257,0.00966114521239857,FALSE +"H1975","Pearson.est","JAK inhibitor",0.36894,0.927,0.561,217,0.874,"LY2784544, pacritinib, baricitinib, TG.101348, CEP.33779, AZD1480",0.251037138743839,0.058488567365597,FALSE +"H1975","Pearson.est","KIT inhibitor",-0.35427,-0.952,0.473,1413,0.832,"midostaurin, dasatinib, KI.8751",0.325138859262188,0.0798766737092761,FALSE +"H1975","Pearson.est","MDM inhibitor",-0.52533,-1.43,0.117,1162,0.335,"idasanutlin, AMG.232, serdemetan, RITA",0.931814138253838,0.474955192963155,FALSE +"H1975","Pearson.est","MEK inhibitor",-0.69387,-1.9,0.0211,1150,0.0777,"U.0126, MEK162, PD.198306, PD.98059, AS.703026, cobimetinib, trametinib, Ro.4987655, TAK.733, selumetinib, PD.318088, AZD8330, refametinib, PD.184352",1.67571754470231,1.10957898119909,TRUE +"H1975","Pearson.est","MET inhibitor",0.27174,0.677,0.84,326,0.951,"AMG458, INC.280",0.0757207139381184,0.0218194830625861,FALSE +"H1975","Pearson.est","microtubule inhibitor",0.44102,1.11,0.329,475,0.816,"colchicine, D.64131, podophyllotoxin, triclabendazole, vinflunine, cabazitaxel",0.482804102050026,0.0883098412461389,FALSE +"H1975","Pearson.est","mTOR inhibitor",-0.53595,-1.44,0.105,1082,0.405,"ku.0063794, AZD2014, GSK2126458, GDC.0980, deforolimus, WYE.354, OSI.027, PKI.179, everolimus, MLN0128, LY3023414, temsirolimus, torin.1, NVP.BEZ235, PF.04691502, SB.2343",0.978810700930062,0.392544976785331,FALSE +"H1975","Pearson.est","NFkB pathway inhibitor",-0.29111,-0.774,0.692,1218,0.997,"EVP4593, BAY.11.7085, BAY.11.7082",0.159893905543242,0.00130484168834428,FALSE +"H1975","Pearson.est","opioid receptor agonist",0.38996,0.957,0.483,21,0.926,"salvinorin.a",0.316052869248488,0.0333890133180656,FALSE +"H1975","Pearson.est","p38 MAPK inhibitor",0.51409,1.3,0.173,357,0.612,"talmapimod, SB.242235, SB.239063, TAK.715",0.761953896871205,0.213248577854439,FALSE +"H1975","Pearson.est","PARP inhibitor",0.44778,1.1,0.351,22,0.769,"PJ.34",0.454692883534176,0.114073660198569,FALSE +"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.3734,-1.02,0.391,1299,0.739,"linifanib, SU014813, axitinib, ponatinib, dasatinib, KI.8751",0.407823242604133,0.131355561605174,FALSE +"H1975","Pearson.est","phosphatase inhibitor",0.29643,0.75,0.754,261,0.912,"AS.1949490, mycophenolic.acid",0.122628654130226,0.0400051616715838,FALSE +"H1975","Pearson.est","phosphodiesterase inhibitor",0.35024,0.864,0.636,360,0.871,"cilostamide, YM.976, enoximone",0.196542884351586,0.0599818449923368,FALSE +"H1975","Pearson.est","PI3K inhibitor",-0.41706,-1.09,0.345,1099,0.651,"PI.828, BGT226, GSK2126458, GDC.0980, PI3K.IN.2, PKI.179, LY3023414, ZSTK.474, GDC.0941, buparlisib, NVP.BEZ235, PF.04691502, SB.2343",0.462180904926726,0.186419011431808,FALSE +"H1975","Pearson.est","PLK inhibitor",0.68434,1.79,0.0198,324,0.737,"BI.2536, NMS.1286937, GSK461364, GW.843682X, volasertib",1.70333480973847,0.132532512140949,FALSE +"H1975","Pearson.est","potassium channel blocker",0.47016,1.18,0.272,266,0.815,"dofetilide, oleoylethanolamide, ML133",0.565431095965801,0.0888423912600234,FALSE +"H1975","Pearson.est","PPAR receptor agonist",-0.3077,-0.844,0.612,1371,1,"fenofibrate",0.213248577854439,0,FALSE +"H1975","Pearson.est","progesterone receptor agonist",-0.41986,-1.13,0.314,1199,0.623,"norgestrel, norethindrone, tanaproget",0.503070351926785,0.20551195334083,FALSE +"H1975","Pearson.est","proteasome inhibitor",0.45128,1.16,0.3,576,0.818,"MG.132, ixazomib, delanzomib, carfilzomib, bortezomib",0.522878745280338,0.087246696328677,FALSE +"H1975","Pearson.est","protein synthesis inhibitor",0.45415,1.13,0.335,433,0.808,"bruceantin, homoharringtonine, harringtonine, puromycin, chloramphenicol.palmitate, clofoctol, thiostrepton, emetine, tedizolid.phosphate, anguidine",0.474955192963155,0.0925886392254138,FALSE +"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.3357,0.842,0.644,435,0.844,"CP.724714, tyrphostin.A9, AV.412, BMS.599626, rheochrysidin",0.191114132640188,0.073657553374345,FALSE +"H1975","Pearson.est","RAF inhibitor",0.57967,1.48,0.0923,446,0.471,"regorafenib, CEP.32496, SB.590885, AZ.628, GDC.0879, vemurafenib, LGX818, RAF265, dabrafenib",1.03479829897409,0.326979092871104,FALSE +"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.35314,0.897,0.571,262,0.882,"regorafenib, apatinib",0.243363891754152,0.0545314148681803,FALSE +"H1975","Pearson.est","retinoid receptor agonist",0.61628,1.52,0.0563,193,0.43,"adarotene, AM.580, tamibarotene, CD.437",1.24949160514865,0.366531544420413,FALSE +"H1975","Pearson.est","ribonucleotide reductase inhibitor",0.22685,0.568,0.947,480,0.96,"fludarabine.phosphate, gemcitabine, fludarabine",0.0236500209967266,0.0177287669604316,FALSE +"H1975","Pearson.est","serotonin receptor agonist",-0.52871,-1.43,0.13,1447,0.335,"aripiprazole",0.886056647693163,0.474955192963155,FALSE +"H1975","Pearson.est","serotonin receptor antagonist",-0.29287,-0.777,0.71,1447,1,"aripiprazole",0.148741651280925,0,FALSE +"H1975","Pearson.est","sodium channel blocker",-0.24513,-0.656,0.868,913,1,"quinidine, cibenzoline, butamben, benzocaine, A.803467, oxcarbazepine, benzethonium, mexiletine, mepivacaine",0.0614802748235081,0,FALSE +"H1975","Pearson.est","src inhibitor",0.34355,0.883,0.566,268,0.885,"KX2.391, TG.100572, saracatinib",0.247183568811729,0.0530567293021746,FALSE +"H1975","Pearson.est","sterol demethylase inhibitor",0.35615,0.914,0.543,403,0.874,"ketoconazole, lanoconazole, posaconazole",0.265200170411153,0.058488567365597,FALSE +"H1975","Pearson.est","TGF beta receptor inhibitor",0.71786,1.78,0.0168,127,0.398,"LY2109761, repsox, SB.525334",1.77469071827414,0.400116927926312,FALSE +"H1975","Pearson.est","thymidylate synthase inhibitor",0.69834,1.77,0.0151,441,0.292,"ftorafur, doxifluridine, trifluridine, raltitrexed, carmofur, capecitabine",1.82102305270683,0.534617148551582,FALSE +"H1975","Pearson.est","topoisomerase inhibitor",0.33144,0.836,0.643,282,0.814,"dexrazoxane, SN.38, exatecan.mesylate, genz.644282, topotecan, camptothecin, nemorubicin",0.191789027075778,0.0893755951107988,FALSE +"H1975","Pearson.est","tubulin polymerization inhibitor",0.5305,1.37,0.141,567,0.629,"vinorelbine, vincristine, KX2.391, combretastatin.A.4, CYT.997, taltobulin, podophyllotoxin, plinabulin, dolastatin.10, indibulin, oxibendazole, albendazole, ABT.751, epothilone.d, vindesine, flubendazole, nocodazole, mebendazole",0.85078088734462,0.201349354554731,FALSE +"H1975","Pearson.est","tyrosine kinase inhibitor",-0.29572,-0.794,0.682,1345,1,"cabozantinib, aminopurvalanol.a, UNC2250, dasatinib, NVP.TAE226",0.166215625343521,0,FALSE +"H1975","Pearson.est","VEGFR inhibitor",-0.24199,-0.649,0.892,1299,0.976,"linifanib, semaxanib, SU014813, SAR131675, cabozantinib, axitinib, KI.8751",0.0496351456238769,0.0105501823333082,FALSE +"H1975","Pearson.est","vitamin D receptor agonist",0.44857,1.14,0.29,48,0.822,"maxacalcitol",0.537602002101044,0.0851281824599496,FALSE +"H2009","Pearson.est","EGFR inhibitor",-0.37127,-0.92,0.587,993,0.879,"vandetanib, tyrphostin.AG.494, rociletinib, OSI.420, AEE788, osimertinib, TAK.285, pelitinib, WZ8040, canertinib, PD.153035, afatinib, erlotinib, gefitinib, icotinib, BIBX.1382, tyrphostin.AG.1478, BIBU.1361",0.231361898752386,0.0560111249262281,FALSE +"H2009","Pearson.est","Abl kinase inhibitor",-0.16481,-0.404,0.993,1174,0.997,"bafetinib, bosutinib",0.00305075150461883,0.00130484168834428,FALSE +"H2009","Pearson.est","acetylcholine receptor agonist",-0.26812,-0.661,0.863,1325,1,"tremorine",0.0639892042847904,0,FALSE +"H2009","Pearson.est","acetylcholine receptor antagonist",-0.48225,-1.2,0.256,1245,0.853,"dicycloverine, diphemanil",0.59176003468815,0.069050968832477,FALSE +"H2009","Pearson.est","adenosine receptor antagonist",-0.45512,-1.12,0.331,1068,0.846,"SCH.58261, sulmazole, CGS.15943",0.480172006224281,0.0726296369609765,FALSE +"H2009","Pearson.est","adrenergic receptor agonist",-0.27803,-0.684,0.837,714,1,"terbutaline, xylazine, A61603, norepinephrine, oxymetazoline, clenbuterol, metaraminol, isoxsuprine, buphenine, epinephrine",0.07727454200674,0,FALSE +"H2009","Pearson.est","adrenergic receptor antagonist",-0.31521,-0.762,0.771,1217,0.969,"carvedilol, pindolol, levobunolol, propranolol, vincamine",0.112945621949043,0.0136762229492347,FALSE +"H2009","Pearson.est","AKT inhibitor",-0.36963,-0.915,0.57,1060,0.867,"CCT128930, ONC201, uprosertib, triciribine, palomid.529",0.244125144327509,0.0619809025237897,FALSE +"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.4418,-1.05,0.394,713,0.899,"CEP.37440, DMH1, alectinib, crizotinib, NVP.TAE684, lorlatinib, AZD3463, GW.788388",0.404503778174426,0.0462403082667712,FALSE +"H2009","Pearson.est","androgen receptor antagonist",-0.39053,-0.957,0.51,911,0.848,"cyproterone.acetate, flutamide, nilutamide, bicalutamide",0.292429823902064,0.0716041477432862,FALSE +"H2009","Pearson.est","antioxidant",0.40334,1.12,0.304,15,0.902,"trolox",0.517126416391246,0.0447934624580583,FALSE +"H2009","Pearson.est","AP inhibitor",0.27871,0.781,0.725,34,0.836,"idronoxil",0.139661993429006,0.0777937225609836,FALSE +"H2009","Pearson.est","ATPase inhibitor",0.71293,2.05,0.0121,212,0.181,"k.strophanthidin, oligomycin.a, evodiamine, omeprazole, NMS.873, digoxin",1.91721462968355,0.742321425130815,TRUE +"H2009","Pearson.est","Aurora kinase inhibitor",-0.2359,-0.574,0.939,869,1,"MK.8745, KW.2449, tozasertib, ZM.447439, GSK1070916, hesperadin, MK.5108, PF.03814735, MLN.8054",0.0273344077338891,0,FALSE +"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.36617,-0.891,0.603,815,0.797,"dirithromycin, tedizolid, azalomycin.b, azithromycin",0.219682687859849,0.0985416786038876,FALSE +"H2009","Pearson.est","bacterial DNA gyrase inhibitor",-0.3696,-0.894,0.601,1237,0.809,"trovafloxacin, novobiocin",0.22112552799726,0.0920514783877277,FALSE +"H2009","Pearson.est","BCL inhibitor",0.33323,0.952,0.471,356,1,"ABT.737, gossypol, TW.37, venetoclax, obatoclax",0.326979092871104,0,FALSE +"H2009","Pearson.est","Bcr.Abl kinase inhibitor",-0.22682,-0.551,0.942,1174,1,"bafetinib, bosutinib",0.0259490972071227,0,FALSE +"H2009","Pearson.est","benzodiazepine receptor agonist",-0.22798,-0.557,0.951,987,1,"CGS.20625, ZK.93423, indiplon, zaleplon",0.0218194830625861,0,FALSE +"H2009","Pearson.est","bromodomain inhibitor",-0.25327,-0.625,0.895,1252,1,"JQ1....",0.048176964684088,0,FALSE +"H2009","Pearson.est","calcium channel blocker",0.31395,0.898,0.507,106,0.834,"efonidipine.monoethanolate, carboxyamidotriazole",0.294992040666664,0.0788339493622613,FALSE +"H2009","Pearson.est","CC chemokine receptor antagonist",-0.42633,-1.05,0.416,1132,0.899,"MK.0812, PF.04136309, navarixin",0.380906669373257,0.0462403082667712,FALSE +"H2009","Pearson.est","CDK inhibitor",-0.40046,-0.978,0.478,1153,0.924,"JNJ.7706621, arcyriaflavin.a, BMS.387032, kenpaullone, PHA.793887, AZD5438, alvocidib",0.320572103387881,0.0343280287798933,FALSE +"H2009","Pearson.est","CHK inhibitor",-0.52406,-1.26,0.197,965,1,"SB.218078, SCH.900776, LY2606368, LY2603618",0.705533773838407,0,FALSE +"H2009","Pearson.est","cyclooxygenase inhibitor",-0.4912,-1.2,0.256,1154,0.853,"meloxicam, FR.122047, amfenac, indoprofen, curcumin, ramifenazone, aspirin, FK.3311",0.59176003468815,0.069050968832477,FALSE +"H2009","Pearson.est","cytochrome P450 inhibitor",-0.46809,-1.15,0.306,1085,0.875,"cobicistat, clotrimazole, PF.4981517",0.51427857351842,0.0579919469776868,FALSE +"H2009","Pearson.est","DNA alkylating agent",-0.51487,-1.25,0.191,929,0.977,"ifosfamide, mitomycin.c, satraplatin, TH.302, carboplatin, cyclophosphamide, streptozotocin, melphalan, dacarbazine",0.718966632752272,0.0101054362812269,FALSE +"H2009","Pearson.est","DNA inhibitor",-0.41378,-1.02,0.426,915,0.881,"nimorazole, primaquine, valrubicin, carboplatin, busulfan, tirapazamine, sangivamycin, bendamustine, nithiamide, melphalan",0.370590400897281,0.0550240915879521,FALSE +"H2009","Pearson.est","DNA methyltransferase inhibitor",-0.70589,-1.72,0.00657,1098,0.288,"fdcyd, SGI.1027, decitabine, azacitidine",2.18243463044022,0.540607512240769,FALSE +"H2009","Pearson.est","DNA polymerase inhibitor",0.30707,0.853,0.622,222,0.813,"menadione, cidofovir, adefovir.dipivoxil",0.206209615309181,0.0899094544059319,FALSE +"H2009","Pearson.est","DNA synthesis inhibitor",-0.47395,-1.13,0.314,848,0.893,"enocitabine, nelarabine, mitomycin.c, estramustine.phosphate, cyclocytidine, CB.10.277, anisomycin, floxuridine, altretamine",0.503070351926785,0.0491485411114536,FALSE +"H2009","Pearson.est","dopamine receptor antagonist",-0.37011,-0.896,0.604,970,0.824,"oxiperomide, acetophenazine, amisulpride, sertindole, ziprasidone, piperacetazine, isofloxythepin",0.218963061378868,0.0840727883028842,FALSE +"H2009","Pearson.est","estrogen receptor agonist",-0.30786,-0.749,0.804,1075,0.968,"PPT, estradiol.cypionate, ethinyl.estradiol",0.0947439512515487,0.0141246426916063,FALSE +"H2009","Pearson.est","estrogen receptor antagonist",-0.36732,-0.896,0.589,945,0.824,"fulvestrant, clomifene, raloxifene, toremifene",0.229884705212898,0.0840727883028842,FALSE +"H2009","Pearson.est","FGFR inhibitor",0.44323,1.32,0.147,306,0.665,"erdafitinib, lenvatinib, dovitinib, PD.173074, nintedanib",0.832682665251824,0.177178354696895,FALSE +"H2009","Pearson.est","FLT3 inhibitor",0.3675,1.02,0.412,166,0.936,"ponatinib, TG.101348, sorafenib, GTP.14564, dovitinib, ENMD.2076",0.385102783966865,0.0287241512618947,FALSE +"H2009","Pearson.est","glucocorticoid receptor agonist",0.59498,1.72,0.0338,232,0.254,"dexamethasone.acetate, triamcinolone.acetonide, triamcinolone, halcinonide, hydrocortisone, desonide, beclomethasone.dipropionate, fluticasone.propionate, deflazacort, flumethasone.pivalate, piretanide, betamethasone, fluocinolone.acetonide, rimexolone, prednisolone.hemisuccinate",1.47108329972235,0.595166283380062,FALSE +"H2009","Pearson.est","glutamate receptor antagonist",-0.45547,-1.11,0.357,850,0.837,"MTPG, JNJ.16259685, tiletamine, SIB.1757, latrepirdine, ACDPP, diazooxonorleucine",0.447331783887807,0.07727454200674,FALSE +"H2009","Pearson.est","glycogen synthase kinase inhibitor",-0.49901,-1.22,0.243,881,0.891,"CHIR.99021, LY2090314, tideglusib, GSK.3.inhibitor.IX, kenpaullone, AZD2858",0.614393726401688,0.0501222959631252,FALSE +"H2009","Pearson.est","growth factor receptor inhibitor",-0.39474,-0.965,0.506,885,0.876,"GSK1904529A, GSK1838705A, AZD3463, GW.441756",0.295849483160201,0.0574958938319193,FALSE +"H2009","Pearson.est","HCV inhibitor",-0.61912,-1.51,0.0638,1268,0.525,"narlaprevir, PSI.7976, daclatasvir",1.19517932127884,0.279840696594043,FALSE +"H2009","Pearson.est","HDAC inhibitor",-0.48424,-1.17,0.284,955,0.857,"dacinostat, givinostat, entinostat, nexturastat.a, chidamide, M.344, romidepsin, AR.42, R306465, PCI.24781, tacedinaline, panobinostat, vorinostat, SB.939, JNJ.26481585",0.546681659952962,0.0670191780768018,FALSE +"H2009","Pearson.est","histamine receptor antagonist",-0.55278,-1.35,0.133,937,0.829,"tiotidine, ranitidine, cimetidine, levocetirizine, ICI.162846, lafutidine, cyproheptadine, famotidine, nizatidine, pheniramine, terfenadine, tecastemizole, chloropyramine, zolantidine",0.876148359032914,0.0814454694497265,FALSE +"H2009","Pearson.est","HMGCR inhibitor",-0.40327,-0.988,0.488,1002,0.928,"simvastatin, mevastatin",0.311580177997289,0.0324520237811379,FALSE +"H2009","Pearson.est","HSP inhibitor",-0.59206,-1.46,0.0642,1150,0.606,"VER.49009, XL888, tanespimycin, BIIB021, NVP.AUY922, SNX.2112, PU.H71, SNX.5422",1.19246497193115,0.217527375833714,FALSE +"H2009","Pearson.est","JAK inhibitor",-0.39726,-0.974,0.495,1267,0.906,"pacritinib, atiprimod, CEP.33779, WHI.P154, LY2784544",0.305394801066431,0.0428718023231869,FALSE +"H2009","Pearson.est","KIT inhibitor",0.27305,0.772,0.714,247,0.806,"lenvatinib, sorafenib, dasatinib, pazopanib, motesanib",0.146301788223826,0.0936649581949093,FALSE +"H2009","Pearson.est","MDM inhibitor",-0.41922,-1.03,0.432,844,0.887,"RITA, nutlin.3, serdemetan",0.364516253185088,0.0520763801682736,FALSE +"H2009","Pearson.est","MEK inhibitor",-0.36429,-0.901,0.575,745,0.873,"U.0126, PD.0325901, MEK162, AS.703026, cobimetinib, arctigenin, trametinib, PD.98059, Ro.4987655, TAK.733, PD.198306, BIX.02188, nobiletin",0.24033215531037,0.0589857562944303,FALSE +"H2009","Pearson.est","MET inhibitor",-0.7088,-1.72,0.0121,1101,0.288,"LY2801653, PF.04217903, AMG458, NVP.BVU972, INC.280",1.91721462968355,0.540607512240769,FALSE +"H2009","Pearson.est","microtubule inhibitor",-0.39681,-0.964,0.512,991,0.855,"estramustine.phosphate, D.64131, cabazitaxel, podophyllotoxin",0.290730039024169,0.0680338852718274,FALSE +"H2009","Pearson.est","mTOR inhibitor",0.33091,0.936,0.514,199,0.883,"OSI.027, torin.1, voxtalisib, PF.04691502, WYE.354, XL388, WYE.125132, SB.2343, AZD2014, everolimus",0.289036881004724,0.0540392964224314,FALSE +"H2009","Pearson.est","NFkB pathway inhibitor",0.31078,0.878,0.618,23,0.818,"EVP4593, tyloxapol",0.209011524911184,0.087246696328677,FALSE +"H2009","Pearson.est","opioid receptor agonist",-0.39491,-0.969,0.495,1428,0.892,"salvinorin.a",0.305394801066431,0.0496351456238769,FALSE +"H2009","Pearson.est","p38 MAPK inhibitor",-0.70047,-1.71,0.0161,1343,0.231,"VX.702, TAK.715, CMPD.1",1.79317412396815,0.636388020107856,TRUE +"H2009","Pearson.est","PARP inhibitor",-0.55775,-1.38,0.124,1105,0.805,"talazoparib, olaparib, PJ.34, niraparib",0.906578314837765,0.0942041196321315,FALSE +"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.38357,1.11,0.285,195,0.815,"lenvatinib, axitinib, ponatinib, linifanib, sorafenib, dasatinib, SU014813, dovitinib, pazopanib",0.54515513999149,0.0888423912600234,FALSE +"H2009","Pearson.est","phosphatase inhibitor",0.33476,0.95,0.504,162,0.93,"GSK2830371, menadione, CID.5458317",0.297569463554475,0.0315170514460649,FALSE +"H2009","Pearson.est","phosphodiesterase inhibitor",-0.45725,-1.12,0.32,1218,0.846,"cilostamide, zardaverine, YM.976, EMD.53998",0.494850021680094,0.0726296369609765,FALSE +"H2009","Pearson.est","PI3K inhibitor",0.2959,0.841,0.65,184,0.785,"ZSTK.474, voxtalisib, PF.04691502, GDC.0941, PI3K.IN.2, buparlisib, SB.2343, idelalisib",0.187086643357144,0.105130343254747,FALSE +"H2009","Pearson.est","PLK inhibitor",-0.49398,-1.22,0.216,827,0.891,"GW.843682X, GSK461364, HMN.214, BI.2536",0.665546248849069,0.0501222959631252,FALSE +"H2009","Pearson.est","potassium channel blocker",-0.50472,-1.25,0.205,1178,0.977,"oleoylethanolamide, meglitinide",0.688246138944246,0.0101054362812269,FALSE +"H2009","Pearson.est","PPAR receptor agonist",-0.19407,-0.466,0.991,910,1,"GW.501516, ciprofibrate, oleoylethanolamide",0.00392634551472468,0,FALSE +"H2009","Pearson.est","progesterone receptor agonist",0.50753,1.4,0.15,152,0.639,"norethindrone, tanaproget, levonorgestrel",0.823908740944319,0.1944991418416,FALSE +"H2009","Pearson.est","proteasome inhibitor",-0.65176,-1.62,0.0241,948,0.3,"MG.132, ONX.0914, carfilzomib, bortezomib, delanzomib, ixazomib.citrate, ixazomib",1.61798295742513,0.522878745280338,FALSE +"H2009","Pearson.est","protein synthesis inhibitor",-0.23863,-0.58,0.942,998,1,"mercaptopurine, thiostrepton, brefeldin.a, puromycin, homoharringtonine, emetine",0.0259490972071227,0,FALSE +"H2009","Pearson.est","protein tyrosine kinase inhibitor",0.4203,1.22,0.201,44,0.771,"mubritinib, PP.121",0.696803942579511,0.112945621949043,FALSE +"H2009","Pearson.est","RAF inhibitor",-0.50506,-1.24,0.216,1273,0.942,"vemurafenib, GDC.0879, dabrafenib, LGX818, CEP.32496",0.665546248849069,0.0259490972071227,FALSE +"H2009","Pearson.est","RET tyrosine kinase inhibitor",-0.23608,-0.574,0.949,858,1,"cabozantinib, vandetanib, apatinib",0.0227337875727074,0,FALSE +"H2009","Pearson.est","retinoid receptor agonist",-0.42075,-1.04,0.409,1194,0.892,"tamibarotene, AM.580, CD.437",0.388276691992658,0.0496351456238769,FALSE +"H2009","Pearson.est","ribonucleotide reductase inhibitor",-0.43952,-1.06,0.386,1152,0.94,"gemcitabine, fludarabine.phosphate, clofarabine, fludarabine",0.413412695328245,0.0268721464003014,FALSE +"H2009","Pearson.est","serotonin receptor agonist",0.68981,1.98,0.0202,65,0.131,"aripiprazole, zolmitriptan",1.69464863055338,0.882728704344236,TRUE +"H2009","Pearson.est","serotonin receptor antagonist",0.32412,0.926,0.528,2,0.839,"aripiprazole",0.277366077466188,0.0762380391712997,FALSE +"H2009","Pearson.est","sodium channel blocker",-0.21328,-0.517,0.978,953,1,"lappaconite, mexiletine, butamben, ajmaline, triamterene",0.00966114521239857,0,FALSE +"H2009","Pearson.est","src inhibitor",-0.36605,-0.898,0.605,1107,0.858,"saracatinib, KX2.391, bosutinib",0.218244625347531,0.0665127121512946,FALSE +"H2009","Pearson.est","sterol demethylase inhibitor",-0.37498,-0.932,0.563,1244,0.878,"ketoconazole, lanoconazole",0.249491605148654,0.0565054840938974,FALSE +"H2009","Pearson.est","TGF beta receptor inhibitor",-0.67055,-1.63,0.0267,1380,0.336,"D.4476, LY2109761",1.57348873863542,0.473660722610156,FALSE +"H2009","Pearson.est","thymidylate synthase inhibitor",-0.72644,-1.79,0.00941,1262,0.454,"carmofur, raltitrexed, doxifluridine",2.02641037657274,0.342944147142896,FALSE +"H2009","Pearson.est","topoisomerase inhibitor",-0.49982,-1.19,0.25,960,0.838,"TAS.103, teniposide, valrubicin, amonafide, etoposide, amsacrine, topotecan, nemorubicin, irinotecan, rubitecan, licochalcone.a, camptothecin, SN.38, genz.644282, exatecan.mesylate",0.602059991327962,0.0767559813697235,FALSE +"H2009","Pearson.est","tubulin polymerization inhibitor",-0.32717,-0.81,0.707,668,0.914,"albendazole, ABT.751, flubendazole, docetaxel, BNC105, vincristine, indibulin, dolastatin.10, oxibendazole, vinorelbine, CYT.997, plinabulin, epothilone.b, mebendazole, fosbretabulin, epothilone.d, KX2.391, podophyllotoxin, taltobulin, combretastatin.A.4",0.150580586203101,0.0390538042661686,FALSE +"H2009","Pearson.est","tyrosine kinase inhibitor",0.2191,0.629,0.911,149,0.901,"mubritinib, PP.121, sorafenib, GTP.14564, dasatinib",0.0404816230270017,0.045275209020937,FALSE +"H2009","Pearson.est","VEGFR inhibitor",0.26266,0.752,0.786,278,0.795,"lenvatinib, axitinib, linifanib, semaxanib, sorafenib, SU014813, dovitinib, ENMD.2076, pazopanib, motesanib, ZM.306416, PD.173074",0.104577453960592,0.0996328713435297,FALSE +"H2009","Pearson.est","vitamin D receptor agonist",-0.28173,-0.684,0.857,1416,1,"ercalcitriol",0.0670191780768018,0,FALSE +"H2126","Pearson.est","EGFR inhibitor",-0.47556,-1.23,0.22,1178,0.541,"neratinib, CGP.52411, rociletinib, poziotinib, CNX.2006, vandetanib, BIBX.1382, BMS.599626, GW.583340, tucatinib, BIBU.1361, dacomitinib, pelitinib, PD.168393, PD.153035, AST.1306, OSI.420, CP.724714, WZ8040",0.657577319177794,0.266802734893431,FALSE +"H2126","Pearson.est","Abl kinase inhibitor",0.35603,0.921,0.554,308,0.845,"GZD824, ponatinib, bafetinib, nilotinib, KW.2449, dasatinib",0.25649023527157,0.0731432910503077,FALSE +"H2126","Pearson.est","acetylcholine receptor agonist",-0.3372,-0.885,0.587,1416,0.826,"oxiracetam",0.231361898752386,0.0830199526796178,FALSE +"H2126","Pearson.est","acetylcholine receptor antagonist",-0.49974,-1.28,0.191,904,0.653,"methscopolamine, darifenacin, dicycloverine, diphemanil",0.718966632752272,0.185086818724926,FALSE +"H2126","Pearson.est","adenosine receptor antagonist",-0.65258,-1.67,0.0342,1358,0.392,"MRS.1220, CGS.15943, istradefylline",1.46597389394386,0.406713932979543,FALSE +"H2126","Pearson.est","adrenergic receptor agonist",0.3856,1.01,0.435,194,0.759,"epinephrine, terbutaline, norepinephrine, clenbuterol, buphenine",0.361510743045363,0.11975822410452,FALSE +"H2126","Pearson.est","adrenergic receptor antagonist",-0.24192,-0.636,0.889,1061,0.957,"prazosin, atenolol...., RS.17053, pindolol, imiloxan, dronedarone",0.0510982390297863,0.0190880622231565,FALSE +"H2126","Pearson.est","AKT inhibitor",-0.44046,-1.13,0.334,1343,0.615,"CCT128930, A.674563, AT7867",0.476253533188435,0.211124884224583,FALSE +"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.58118,1.53,0.0851,349,0.414,"brigatinib, DMH1, alectinib, CEP.37440, crizotinib, SB.505124, lorlatinib",1.07007043991541,0.382999658879101,FALSE +"H2126","Pearson.est","androgen receptor antagonist",-0.56449,-1.42,0.122,814,0.679,"bicalutamide, flutamide, nilutamide, enzalutamide, cyproterone.acetate, RU.58841",0.913640169325252,0.168130225719498,FALSE +"H2126","Pearson.est","antioxidant",-0.4806,-1.25,0.202,937,0.662,"trolox, taurine, benfotiamine",0.694648630553376,0.1791420105603,FALSE +"H2126","Pearson.est","AP inhibitor",-0.58038,-1.48,0.1,1103,0.628,"LCL.161, embelin, tanshinone.i",1,0.202040356262804,FALSE +"H2126","Pearson.est","ATPase inhibitor",0.47184,1.22,0.233,376,0.775,"digitoxigenin, oligomycin.a, digitoxin, rabeprazole, ouabain, NMS.873, k.strophanthidin",0.632644078973981,0.11069829749369,FALSE +"H2126","Pearson.est","Aurora kinase inhibitor",0.48744,1.31,0.166,394,0.753,"CCT137690, AMG900, barasertib, MK.8745, KW.2449, danusertib, GSK1070916, PF.03814735, barasertib.HQPA, ENMD.2076, SNS.314, MK.5108",0.779891911959945,0.123205023799299,FALSE +"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.29619,0.78,0.709,291,0.832,"azithromycin, tedizolid, josamycin",0.149353764816933,0.0798766737092761,FALSE +"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.36265,0.947,0.494,253,0.826,"finafloxacin, lomefloxacin, sparfloxacin",0.306273051076353,0.0830199526796178,FALSE +"H2126","Pearson.est","BCL inhibitor",0.2686,0.692,0.815,68,0.889,"oridonin",0.0888423912600234,0.0510982390297863,FALSE +"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.42072,1.08,0.343,308,0.796,"GZD824, ponatinib, bafetinib, nilotinib, dasatinib",0.464705879957229,0.0990869322623309,FALSE +"H2126","Pearson.est","benzodiazepine receptor agonist",0.35236,0.905,0.56,145,0.79,"bentazepam, piperazine, ZK.93423",0.2518119729938,0.102372908709559,FALSE +"H2126","Pearson.est","bromodomain inhibitor",-0.4382,-1.13,0.317,1033,0.615,"I.BET.762, bromosporine",0.498940737782249,0.211124884224583,FALSE +"H2126","Pearson.est","calcium channel blocker",-0.40838,-1.07,0.373,1126,0.636,"SKF.96365, tetrandrine, SR.33805, cinnarazine, mibefradil",0.428291168191312,0.196542884351586,FALSE +"H2126","Pearson.est","CC chemokine receptor antagonist",0.78507,2.07,0.00209,35,0.0792,"UNBS.5162, ZK811752",2.67985371388895,1.10127481841051,TRUE +"H2126","Pearson.est","CDK inhibitor",-0.43267,-1.1,0.345,1259,0.609,"ribociclib, dinaciclib, CR8..R., arcyriaflavin.a, AT.7519, TG.02, indirubin",0.462180904926726,0.215382707367125,FALSE +"H2126","Pearson.est","CHK inhibitor",-0.40365,-1.05,0.412,1213,0.593,"AZD7762, CHIR.124",0.385102783966865,0.226945306635737,FALSE +"H2126","Pearson.est","cyclooxygenase inhibitor",-0.28339,-0.713,0.816,1281,0.914,"FR.122047, phenylbutazone, naproxen, tryptanthrin",0.0883098412461389,0.0390538042661686,FALSE +"H2126","Pearson.est","cytochrome P450 inhibitor",0.37618,0.984,0.465,195,0.78,"eplerenone, clotrimazole, PF.4981517",0.332547047110046,0.10790539730952,FALSE +"H2126","Pearson.est","DNA alkylating agent",0.32096,0.847,0.596,516,0.816,"dianhydrogalactitol, carmustine, carboplatin, melphalan, mitomycin.c, cyclophosphamide, temozolomide, estramustine, TH.302",0.224753740259764,0.0883098412461389,FALSE +"H2126","Pearson.est","DNA inhibitor",0.41373,1.07,0.349,292,0.776,"teroxirone, chlorambucil, carmustine, mechlorethamine, carboplatin, tirapazamine, melphalan",0.45717457304082,0.110138278741812,FALSE +"H2126","Pearson.est","DNA methyltransferase inhibitor",0.34514,0.911,0.554,252,0.835,"SGI.1027, decitabine",0.25649023527157,0.0783135245163979,FALSE +"H2126","Pearson.est","DNA polymerase inhibitor",-0.33698,-0.871,0.566,1106,0.821,"famciclovir, adefovir.dipivoxil, cidofovir",0.247183568811729,0.0856568428805592,FALSE +"H2126","Pearson.est","DNA synthesis inhibitor",-0.22905,-0.592,0.92,1091,0.925,"cisplatin, estramustine.phosphate, anisomycin, altretamine",0.0362121726544447,0.0338582672609674,FALSE +"H2126","Pearson.est","dopamine receptor antagonist",-0.40883,-1.06,0.377,978,0.601,"mesoridazine, amisulpride, UH.232...., oxiperomide, clebopride, acetophenazine, piperacetazine, nemonapride, remoxipride",0.423658649794207,0.22112552799726,FALSE +"H2126","Pearson.est","estrogen receptor agonist",0.27025,0.712,0.807,51,0.886,"estradiol.cypionate",0.0931264652779296,0.0525662781129492,FALSE +"H2126","Pearson.est","estrogen receptor antagonist",-0.33018,-0.856,0.608,1384,0.82,"tamoxifen",0.216096420727265,0.0861861476162833,FALSE +"H2126","Pearson.est","FGFR inhibitor",0.4432,1.14,0.299,91,0.801,"erdafitinib, dovitinib, regorafenib",0.52432881167557,0.0963674839157623,FALSE +"H2126","Pearson.est","FLT3 inhibitor",0.34316,0.891,0.555,337,0.789,"dovitinib, tyrphostin.AG.1296, ponatinib, sorafenib, KW.2449, gilteritinib, tandutinib, ENMD.2076",0.255707016877324,0.10292299679058,FALSE +"H2126","Pearson.est","glucocorticoid receptor agonist",0.33695,0.88,0.599,448,0.784,"fluticasone.propionate, prednisolone, ciclesonide, prednisolone.hemisuccinate, flumethasone.pivalate, triamcinolone, fluocinolone.acetonide, halobetasol.propionate, desonide, triamcinolone.acetonide, clobetasol.propionate, prednisolone.acetate, betamethasone, fludroxycortide",0.222573177610689,0.105683937315562,FALSE +"H2126","Pearson.est","glutamate receptor antagonist",-0.30166,-0.774,0.716,1345,0.903,"latrepirdine, CPP",0.145086977692144,0.0443122496864942,FALSE +"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.5144,-1.29,0.207,1048,0.69,"AZD2858, CHIR.98014, kenpaullone, GSK.3.inhibitor.IX, LY2090314, indirubin",0.684029654543082,0.161150909262745,FALSE +"H2126","Pearson.est","growth factor receptor inhibitor",0.60365,1.62,0.0587,75,0.367,"PHA.848125, GSK1838705A",1.23136189875239,0.435333935747911,FALSE +"H2126","Pearson.est","HCV inhibitor",0.41658,1.08,0.337,235,0.796,"narlaprevir, mericitabine, daclatasvir",0.472370099128661,0.0990869322623309,FALSE +"H2126","Pearson.est","HDAC inhibitor",-0.63079,-1.61,0.0609,1000,0.425,"RGFP966, AR.42, givinostat, dacinostat, resminostat, panobinostat, R306465, vorinostat, tacedinaline, PCI.24781, ACY.1215, RG2833, M.344, entinostat, mocetinostat, scriptaid, SB.939, romidepsin, JNJ.26481585",1.21538270736712,0.371611069949688,FALSE +"H2126","Pearson.est","histamine receptor antagonist",-0.45156,-1.16,0.29,1087,0.626,"tiotidine, astemizole, levocetirizine, famotidine, ranitidine, epinastine, BF2.649, tecastemizole, chloropyramine",0.537602002101044,0.20342566678957,FALSE +"H2126","Pearson.est","HMGCR inhibitor",-0.28918,-0.747,0.756,417,0.892,"pitavastatin, atorvastatin, fluvastatin, lovastatin, simvastatin, mevastatin",0.121478204498793,0.0496351456238769,FALSE +"H2126","Pearson.est","HSP inhibitor",-0.40478,-1.06,0.388,1246,0.601,"alvespimycin, XL888, tanespimycin, VER.49009, KW.2478",0.411168274405793,0.22112552799726,FALSE +"H2126","Pearson.est","JAK inhibitor",-0.28887,-0.751,0.766,1394,0.913,"TG.02, pacritinib",0.115771230367396,0.039529222465701,FALSE +"H2126","Pearson.est","KIT inhibitor",0.30687,0.795,0.66,308,0.831,"regorafenib, OSI.930, masitinib, sorafenib, tandutinib, dasatinib",0.180456064458131,0.080398976215889,FALSE +"H2126","Pearson.est","MDM inhibitor",-0.54331,-1.41,0.123,1184,0.617,"idasanutlin, AMG.232, CGM097, RITA",0.910094888560602,0.209714835966758,FALSE +"H2126","Pearson.est","MEK inhibitor",-0.30072,-0.786,0.687,1339,0.912,"nobiletin, selumetinib, BIX.02188",0.16304326294045,0.0400051616715838,FALSE +"H2126","Pearson.est","MET inhibitor",0.4964,1.28,0.214,74,0.756,"LY2801653",0.669586226650809,0.121478204498793,FALSE +"H2126","Pearson.est","microtubule inhibitor",-0.36566,-0.911,0.553,1188,0.808,"cytochalasin.b, triclabendazole, colchicine, estramustine.phosphate",0.257274868695302,0.0925886392254138,FALSE +"H2126","Pearson.est","mTOR inhibitor",0.42238,1.09,0.343,262,0.866,"ku.0063794, PP242, AZD2014, SB.2343, PI.103, MLN0128, WYE.125132, OSI.027",0.464705879957229,0.0624821079826534,FALSE +"H2126","Pearson.est","NFkB pathway inhibitor",-0.43049,-1.12,0.305,1260,0.603,"IKK.2.inhibitor.V, tyloxapol, Ro.106.9920, parthenolide",0.515700160653214,0.219682687859849,FALSE +"H2126","Pearson.est","opioid receptor agonist",0.34591,0.909,0.541,132,0.81,"BW.180C, spiradoline",0.266802734893431,0.0915149811213502,FALSE +"H2126","Pearson.est","p38 MAPK inhibitor",0.45605,1.17,0.261,462,0.783,"talmapimod, CMPD.1, SB.239063, skepinone.l",0.583359492661719,0.106238237942057,FALSE +"H2126","Pearson.est","PARP inhibitor",0.39439,1.02,0.413,367,0.771,"olaparib, AZD2461, talazoparib, PJ.34, niraparib",0.384049948343599,0.112945621949043,FALSE +"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.30403,0.81,0.683,308,0.831,"dovitinib, regorafenib, ponatinib, masitinib, sorafenib, tandutinib, dasatinib",0.165579296318467,0.080398976215889,FALSE +"H2126","Pearson.est","phosphatase inhibitor",0.22685,0.574,0.944,265,0.964,"sodium.stibogluconate, alexidine",0.025028005701931,0.0159229660971692,FALSE +"H2126","Pearson.est","phosphodiesterase inhibitor",-0.25485,-0.664,0.85,1211,0.951,"avanafil, anagrelide",0.0705810742857073,0.0218194830625861,FALSE +"H2126","Pearson.est","PI3K inhibitor",0.25288,0.667,0.853,452,0.898,"buparlisib, SB.2343, PI.103, GDC.0941, CH5132799, PI3K.IN.2, ZSTK.474, BGT226, GDC.0980, NVP.BEZ235, PF.04691502",0.069050968832477,0.0467236633326956,FALSE +"H2126","Pearson.est","PLK inhibitor",0.79048,2.05,0,229,0.0482,"GW.843682X, HMN.214, NMS.1286937, volasertib, GSK461364, BI.2536",Inf,1.31695296176115,TRUE +"H2126","Pearson.est","potassium channel blocker",-0.71752,-1.8,0.0135,1047,0.242,"dofetilide, oleoylethanolamide, ibutilide, ML133, mepivacaine",1.86966623150499,0.616184634019569,TRUE +"H2126","Pearson.est","PPAR receptor agonist",-0.47535,-1.23,0.228,1028,0.541,"pterostilbene, oleoylethanolamide, clofibrate, S26948, GW.501516",0.642065152999546,0.266802734893431,FALSE +"H2126","Pearson.est","progesterone receptor agonist",0.31772,0.831,0.643,469,0.82,"nomegestrol.acetate, melengestrol.acetate, norgestrel, tanaproget",0.191789027075778,0.0861861476162833,FALSE +"H2126","Pearson.est","proteasome inhibitor",0.68121,1.79,0.0178,60,0.202,"MG.132, delanzomib",1.74957999769111,0.694648630553376,TRUE +"H2126","Pearson.est","protein synthesis inhibitor",0.40305,1.04,0.41,438,0.804,"clofoctol, cycloheximide, mercaptopurine, thiostrepton, chloramphenicol.palmitate, puromycin, methacycline, clindamycin.phosphate",0.387216143280265,0.0947439512515487,FALSE +"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.51192,-1.29,0.194,1095,0.69,"rheochrysidin, BMS.599626, AV.412, CP.724714",0.712198270069774,0.161150909262745,FALSE +"H2126","Pearson.est","RAF inhibitor",0.47008,1.22,0.216,320,0.775,"RAF265, SB.590885, regorafenib, sorafenib, PLX.4720, vemurafenib",0.665546248849069,0.11069829749369,FALSE +"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.45018,1.18,0.277,168,0.815,"regorafenib, sorafenib",0.557520230935551,0.0888423912600234,FALSE +"H2126","Pearson.est","retinoid receptor agonist",0.5962,1.54,0.0743,287,0.454,"adapalene, tamibarotene, LE.135",1.12901118623942,0.342944147142896,FALSE +"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.50627,1.35,0.157,368,0.73,"hydroxyurea, cladribine, triapine, cytarabine, fludarabine.phosphate",0.804100347590766,0.136677139879544,FALSE +"H2126","Pearson.est","serotonin receptor agonist",-0.77708,-1.98,0,1447,0.167,"aripiprazole",Inf,0.777283528852417,TRUE +"H2126","Pearson.est","serotonin receptor antagonist",-0.46938,-1.23,0.234,1447,0.541,"aripiprazole",0.630784142589857,0.266802734893431,FALSE +"H2126","Pearson.est","sodium channel blocker",0.28374,0.745,0.774,69,0.86,"brivaracetam, benzocaine",0.111259039317107,0.0655015487564323,FALSE +"H2126","Pearson.est","src inhibitor",-0.47521,-1.24,0.225,1237,0.636,"TG.100572, bosutinib, PP.2, ZM.306416",0.647817481888638,0.196542884351586,FALSE +"H2126","Pearson.est","sterol demethylase inhibitor",0.73677,1.9,0.0168,110,0.126,"chlormidazole, lanoconazole, sulconazole",1.77469071827414,0.899629454882437,TRUE +"H2126","Pearson.est","TGF beta receptor inhibitor",-0.73176,-1.89,0.013,1393,0.175,"SB.431542, SB.525334, repsox",1.88605664769316,0.756961951313706,TRUE +"H2126","Pearson.est","thymidylate synthase inhibitor",-0.23857,-0.611,0.908,1134,0.932,"carmofur, doxifluridine",0.0419141514789149,0.0305840876460186,FALSE +"H2126","Pearson.est","topoisomerase inhibitor",0.65679,1.72,0.0352,416,0.259,"mitoxantrone, topotecan, amsacrine, etoposide.phosphate, doxorubicin, exatecan.mesylate, idarubicin, TAS.103, genz.644282, dexrazoxane, etoposide, voreloxin, epirubicin, nemorubicin, SN.38, rubitecan, beta.lapachone, daunorubicin, amonafide, valrubicin, irinotecan",1.45345733652187,0.586700235918748,FALSE +"H2126","Pearson.est","tubulin polymerization inhibitor",0.40124,1.03,0.406,449,0.787,"BNC105, mebendazole, taltobulin, verubulin, vinblastine, fenbendazole, oxibendazole, albendazole, flubendazole, indibulin, podophyllotoxin, paclitaxel",0.391473966422806,0.104025267640935,FALSE +"H2126","Pearson.est","tyrosine kinase inhibitor",-0.25222,-0.627,0.842,1222,0.941,"AMG.208, vandetanib, BMS.599626, GTP.14564, AV.412, CP.724714",0.0746879085003505,0.0264103765727431,FALSE +"H2126","Pearson.est","VEGFR inhibitor",0.21048,0.538,0.954,217,0.963,"RAF265, dovitinib, regorafenib, OSI.930, tivozanib, sorafenib, foretinib",0.0204516252959049,0.0163737128754655,FALSE +"H2126","Pearson.est","vitamin D receptor agonist",-0.5224,-1.33,0.179,1158,0.734,"alfacalcidol, tacalcitol, paricalcitol",0.747146969020107,0.134303940083929,FALSE +"H3255","Pearson.est","EGFR inhibitor",-0.56906,-1.42,0.117,1044,0.726,"rociletinib, CUDC.101, GW.583340, BMS.599626, BIBX.1382, XL.647, BMS.690514, CP.724714, vandetanib, TAK.285, tucatinib, neratinib, lapatinib, tyrphostin.AG.1478, AEE788, OSI.420, PD.153035, gefitinib, PD.168393, WZ8040, canertinib, icotinib, afatinib, pelitinib, BIBU.1361, osimertinib, erlotinib",0.931814138253838,0.139063379299906,FALSE +"H3255","Pearson.est","Abl kinase inhibitor",0.29335,0.769,0.755,225,0.881,"GZD824, dasatinib, ponatinib, flumatinib",0.122053048370812,0.0550240915879521,FALSE +"H3255","Pearson.est","acetylcholine receptor agonist",0.43467,1.18,0.239,138,0.915,"nicotine, xanomeline",0.621602099051862,0.0385789059335517,FALSE +"H3255","Pearson.est","acetylcholine receptor antagonist",-0.32041,-0.79,0.708,1400,0.898,"diphemanil",0.149966742310231,0.0467236633326956,FALSE +"H3255","Pearson.est","adenosine receptor antagonist",-0.40494,-0.986,0.471,849,1,"sulmazole, PSB.1115, SCH.58261, MRS.1220, CGS.15943",0.326979092871104,0,FALSE +"H3255","Pearson.est","adrenergic receptor agonist",-0.17542,-0.434,0.997,878,0.994,"A61603, clenbuterol, methyldopa, oxymetazoline, isoxsuprine, epinephrine",0.00130484168834428,0.00261361560268669,FALSE +"H3255","Pearson.est","adrenergic receptor antagonist",-0.338,-0.833,0.681,1191,0.966,"pindolol, vincamine, RS.17053, carvedilol, levobunolol, dronedarone",0.166852888087215,0.0150228735845067,FALSE +"H3255","Pearson.est","AKT inhibitor",-0.40233,-0.981,0.476,1169,0.99,"CCT128930, uprosertib, triciribine, palomid.529",0.322393047279507,0.00436480540245009,FALSE +"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.39296,-0.966,0.499,984,0.922,"GW.788388, CEP.37440, NVP.TAE684, AZD3463",0.30189945437661,0.0352690789463706,FALSE +"H3255","Pearson.est","androgen receptor antagonist",0.29768,0.778,0.716,251,0.945,"RU.58841, enzalutamide",0.145086977692144,0.0245681914907371,FALSE +"H3255","Pearson.est","antioxidant",0.47181,1.24,0.21,13,1,"trolox",0.677780705266081,0,FALSE +"H3255","Pearson.est","AP inhibitor",-0.44779,-1.1,0.365,948,0.814,"embelin, birinapant, tanshinone.i, GDC.0152, LCL.161",0.437707135543525,0.0893755951107988,FALSE +"H3255","Pearson.est","ATPase inhibitor",0.63185,1.7,0.034,406,0.58,"k.strophanthidin, oligomycin.a, evodiamine, digoxin, NMS.873, digitoxigenin, rabeprazole, omeprazole, blebbistatin....",1.46852108295774,0.236572006437063,FALSE +"H3255","Pearson.est","Aurora kinase inhibitor",0.41787,1.11,0.348,345,0.909,"AT.9283, CYC116, barasertib.HQPA, SNS.314, barasertib, TAK.901, ENMD.2076, CCT129202, aurora.a.inhibitor.i, AMG900",0.458420756053419,0.0414361167780325,FALSE +"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34904,-0.876,0.61,1323,0.964,"azalomycin.b, azithromycin",0.214670164989233,0.0159229660971692,FALSE +"H3255","Pearson.est","bacterial DNA gyrase inhibitor",-0.24822,-0.605,0.909,888,0.991,"sparfloxacin, sarafloxacin, novobiocin, trovafloxacin",0.0414361167780325,0.00392634551472468,FALSE +"H3255","Pearson.est","BCL inhibitor",0.33892,0.903,0.563,381,0.937,"ABT.737, gossypol, TW.37, venetoclax, obatoclax",0.249491605148654,0.0282604091122217,FALSE +"H3255","Pearson.est","Bcr.Abl kinase inhibitor",0.31182,0.824,0.686,225,0.948,"GZD824, dasatinib, ponatinib, flumatinib",0.163675884293248,0.0231916626619338,FALSE +"H3255","Pearson.est","benzodiazepine receptor agonist",-0.37427,-0.903,0.581,935,0.937,"indiplon, bentazepam, CGS.20625, ZK.93423, zaleplon",0.235823867609669,0.0282604091122217,FALSE +"H3255","Pearson.est","bromodomain inhibitor",-0.23578,-0.579,0.944,340,0.974,"OTX015, PFI.1, I.BET.762, I.BET151, bromosporine, JQ1....",0.025028005701931,0.0114410431213845,FALSE +"H3255","Pearson.est","calcium channel blocker",0.24409,0.666,0.886,1097,1,"efonidipine.monoethanolate, carboxyamidotriazole, SR.33805, pranidipine, mibefradil, cinnarazine, SKF.96365, penfluridol, tetrandrine, fendiline",0.0525662781129492,0,FALSE +"H3255","Pearson.est","CC chemokine receptor antagonist",-0.29789,-0.742,0.809,1422,0.951,"navarixin",0.0920514783877277,0.0218194830625861,FALSE +"H3255","Pearson.est","CDK inhibitor",-0.34387,-0.833,0.66,975,0.966,"BMS.265246, CR8..R., JNJ.7706621, PHA.793887, BMS.387032, AZD5438, kenpaullone, alvocidib, arcyriaflavin.a",0.180456064458131,0.0150228735845067,FALSE +"H3255","Pearson.est","CHK inhibitor",-0.51598,-1.28,0.203,955,0.648,"CHIR.124, SCH.900776, LY2606368, LY2603618",0.692503962086787,0.188424994129407,FALSE +"H3255","Pearson.est","cyclooxygenase inhibitor",-0.33583,-0.821,0.666,1140,0.913,"FR.122047, suxibuzone, indoprofen, ramifenazone, AM.404, FK.3311",0.176525770829699,0.039529222465701,FALSE +"H3255","Pearson.est","cytochrome P450 inhibitor",0.45553,1.2,0.241,298,1,"metyrapone, itraconazole, morin, eplerenone",0.617982957425132,0,FALSE +"H3255","Pearson.est","DNA alkylating agent",-0.38283,-0.949,0.542,1224,0.928,"mitomycin.c, ifosfamide, melphalan, dacarbazine",0.266000713461613,0.0324520237811379,FALSE +"H3255","Pearson.est","DNA inhibitor",-0.23839,-0.595,0.934,940,0.98,"valrubicin, sangivamycin, busulfan, nithiamide, bendamustine, primaquine, melphalan",0.0296531237699066,0.00877392430750515,FALSE +"H3255","Pearson.est","DNA methyltransferase inhibitor",-0.77542,-1.88,0.00159,1159,0.243,"decitabine, SGI.1027, fdcyd, azacitidine",2.79860287567955,0.614393726401688,TRUE +"H3255","Pearson.est","DNA polymerase inhibitor",0.32569,0.872,0.56,979,0.948,"famciclovir, foscarnet, adefovir.dipivoxil, cidofovir, menadione, idoxuridine, trifluridine, cephalomannine",0.2518119729938,0.0231916626619338,FALSE +"H3255","Pearson.est","DNA synthesis inhibitor",-0.33305,-0.826,0.665,1056,0.928,"capecitabine, enocitabine, anisomycin, mitomycin.c, altretamine, floxuridine",0.177178354696895,0.0324520237811379,FALSE +"H3255","Pearson.est","dopamine receptor antagonist",0.24038,0.651,0.872,255,0.944,"thioproperazine, remoxipride, domperidone, raclopride, nemonapride, clebopride",0.0594835150674328,0.025028005701931,FALSE +"H3255","Pearson.est","estrogen receptor agonist",0.42912,1.16,0.269,430,0.865,"estrone, erteberel, levonorgestrel, estradiol.cypionate, ethinyl.estradiol",0.570247719997592,0.0629838925351858,FALSE +"H3255","Pearson.est","estrogen receptor antagonist",0.38288,1.04,0.371,81,0.79,"tamoxifen",0.430626090384954,0.102372908709559,FALSE +"H3255","Pearson.est","FGFR inhibitor",0.31277,0.835,0.664,203,0.974,"erdafitinib, nintedanib, lenvatinib",0.177831920631982,0.0114410431213845,FALSE +"H3255","Pearson.est","FLT3 inhibitor",0.23836,0.663,0.87,310,0.966,"tyrphostin.AG.1296, ponatinib, GTP.14564, ENMD.2076, TG.101348",0.0604807473813815,0.0150228735845067,FALSE +"H3255","Pearson.est","glucocorticoid receptor agonist",0.58493,1.59,0.0665,105,0.611,"hydrocortisone, dexamethasone.acetate, triamcinolone, beclomethasone.dipropionate, fluticasone.propionate, piretanide, desonide, halcinonide",1.1771783546969,0.213958789757446,FALSE +"H3255","Pearson.est","glutamate receptor antagonist",-0.46282,-1.15,0.286,1277,0.734,"MTPG, diazooxonorleucine, ACDPP",0.543633966870957,0.134303940083929,FALSE +"H3255","Pearson.est","glycogen synthase kinase inhibitor",-0.51666,-1.29,0.182,1148,0.666,"GSK.3.inhibitor.IX, LY2090314, kenpaullone, AZD2858",0.739928612014925,0.176525770829699,FALSE +"H3255","Pearson.est","growth factor receptor inhibitor",-0.39087,-0.972,0.482,1031,0.941,"GSK1838705A, AZD3463, GW.441756",0.31695296176115,0.0264103765727431,FALSE +"H3255","Pearson.est","HCV inhibitor",-0.6267,-1.55,0.0466,916,0.738,"narlaprevir, embelin, Ro.9187, PSI.7976, daclatasvir",1.33161408331,0.131943638176958,FALSE +"H3255","Pearson.est","HDAC inhibitor",-0.58413,-1.45,0.0806,1081,0.996,"pyroxamide, M.344, AR.42, givinostat, nexturastat.a, entinostat, vorinostat, romidepsin, chidamide, tacedinaline, R306465, PCI.24781, panobinostat, JNJ.26481585, SB.939",1.09366495819491,0.00174066157630127,FALSE +"H3255","Pearson.est","histamine receptor antagonist",-0.57888,-1.42,0.122,1073,0.726,"nizatidine, astemizole, terfenadine, levocetirizine, ranitidine, tecastemizole, chloropyramine, cyproheptadine, zolantidine",0.913640169325252,0.139063379299906,FALSE +"H3255","Pearson.est","HMGCR inhibitor",-0.2555,-0.626,0.889,1036,0.991,"simvastatin, mevastatin",0.0510982390297863,0.00392634551472468,FALSE +"H3255","Pearson.est","HSP inhibitor",-0.53476,-1.33,0.147,1011,0.609,"BIIB021, VER.49009, SNX.2112, NVP.AUY922, PU.H71, tanespimycin, alvespimycin, XL888, SNX.5422",0.832682665251824,0.215382707367125,FALSE +"H3255","Pearson.est","JAK inhibitor",-0.22583,-0.556,0.954,1274,0.97,"pacritinib, atiprimod, LY2784544",0.0204516252959049,0.0132282657337552,FALSE +"H3255","Pearson.est","KIT inhibitor",-0.29455,-0.717,0.814,905,0.922,"imatinib, vatalanib, regorafenib, motesanib, OSI.930, telatinib, tandutinib",0.0893755951107988,0.0352690789463706,FALSE +"H3255","Pearson.est","MDM inhibitor",0.23743,0.626,0.912,86,0.905,"AMG.232",0.0400051616715838,0.0433514207947967,FALSE +"H3255","Pearson.est","MEK inhibitor",0.29586,0.804,0.673,122,0.942,"PD.318088, refametinib, MEK1.2.inhibitor",0.171984935776023,0.0259490972071227,FALSE +"H3255","Pearson.est","MET inhibitor",-0.48433,-1.2,0.248,980,0.688,"NVP.BVU972, AMG458, INC.280",0.605548319173784,0.162411561764489,FALSE +"H3255","Pearson.est","microtubule inhibitor",-0.33254,-0.811,0.666,933,0.907,"estramustine.phosphate, vinflunine, cabazitaxel, D.64131, podophyllotoxin",0.176525770829699,0.0423927129399047,FALSE +"H3255","Pearson.est","mTOR inhibitor",0.38209,1,0.439,193,0.826,"torin.1, OSI.027, SB.2343, WYE.354, WYE.125132, PF.04691502, PKI.179, voxtalisib, AZD2014",0.357535479757879,0.0830199526796178,FALSE +"H3255","Pearson.est","NFkB pathway inhibitor",0.41192,1.1,0.312,54,0.853,"EVP4593, tyloxapol",0.505845405981557,0.069050968832477,FALSE +"H3255","Pearson.est","opioid receptor agonist",-0.39348,-0.98,0.478,1395,0.956,"salvinorin.a",0.320572103387881,0.0195421077238999,FALSE +"H3255","Pearson.est","p38 MAPK inhibitor",-0.49154,-1.2,0.262,1078,0.688,"SB.239063, VX.702, TAK.715, CMPD.1",0.581698708680255,0.162411561764489,FALSE +"H3255","Pearson.est","PARP inhibitor",-0.56588,-1.38,0.13,925,0.578,"AZD2461, E7449, olaparib, PJ.34, talazoparib, niraparib",0.886056647693163,0.238072161579471,FALSE +"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.24029,0.627,0.894,212,0.937,"nintedanib, linifanib, axitinib, lenvatinib, dasatinib, ponatinib",0.0486624812040823,0.0282604091122217,FALSE +"H3255","Pearson.est","phosphatase inhibitor",-0.30434,-0.734,0.8,1015,0.92,"mycophenolic.acid, mycophenolate.mofetil, sodium.stibogluconate, AS.1949490",0.0969100130080564,0.0362121726544447,FALSE +"H3255","Pearson.est","phosphodiesterase inhibitor",-0.58397,-1.44,0.11,1099,0.873,"GSK256066, trequinsin, EMD.53998, YM.976, papaverine, zardaverine, cilostamide",0.958607314841775,0.0589857562944303,FALSE +"H3255","Pearson.est","PI3K inhibitor",0.36945,0.979,0.466,191,0.82,"GDC.0941, SB.2343, buparlisib, PF.04691502, ZSTK.474, PKI.179, voxtalisib",0.33161408331,0.0861861476162833,FALSE +"H3255","Pearson.est","PLK inhibitor",-0.56134,-1.4,0.105,1018,0.635,"HMN.214, GSK461364, BI.2536",0.978810700930062,0.197226274708024,FALSE +"H3255","Pearson.est","potassium channel blocker",-0.34691,-0.85,0.644,1120,0.988,"meglitinide, oleoylethanolamide",0.191114132640188,0.00524305541237188,FALSE +"H3255","Pearson.est","PPAR receptor agonist",0.44148,1.18,0.277,38,0.915,"fenofibrate, clofibrate",0.557520230935551,0.0385789059335517,FALSE +"H3255","Pearson.est","progesterone receptor agonist",0.61949,1.7,0.0309,125,0.58,"tanaproget, norethindrone, nomegestrol.acetate",1.51004152057517,0.236572006437063,FALSE +"H3255","Pearson.est","proteasome inhibitor",-0.68074,-1.65,0.0258,1026,0.823,"ONX.0914, MG.132, delanzomib, carfilzomib, ixazomib, bortezomib, ixazomib.citrate",1.58838029403677,0.0846001647877302,FALSE +"H3255","Pearson.est","protein synthesis inhibitor",-0.32834,-0.81,0.694,1165,0.887,"puromycin, brefeldin.a, azomycin..2.nitroimidazole., homoharringtonine, emetine",0.158640529545145,0.0520763801682736,FALSE +"H3255","Pearson.est","protein tyrosine kinase inhibitor",0.29208,0.775,0.721,119,0.909,"mubritinib, PP.121",0.142064735280571,0.0414361167780325,FALSE +"H3255","Pearson.est","RAF inhibitor",-0.5613,-1.39,0.13,1068,0.605,"RAF265, SB.590885, vemurafenib, LGX818, dabrafenib, GDC.0879, CEP.32496",0.886056647693163,0.218244625347531,FALSE +"H3255","Pearson.est","RET tyrosine kinase inhibitor",-0.48579,-1.2,0.249,1223,0.688,"vandetanib, apatinib",0.603800652904264,0.162411561764489,FALSE +"H3255","Pearson.est","retinoid receptor agonist",-0.55544,-1.36,0.153,1240,0.582,"tamibarotene, adarotene, AM.580, CD.437",0.815308569182401,0.235077015350112,FALSE +"H3255","Pearson.est","ribonucleotide reductase inhibitor",-0.495,-1.22,0.238,1142,0.757,"fludarabine.phosphate, gemcitabine, clofarabine, fludarabine",0.623423042943488,0.120904120499927,FALSE +"H3255","Pearson.est","serotonin receptor agonist",0.40237,1.06,0.371,379,0.872,"zolmitriptan, aripiprazole, NAN.190, SR.57227A",0.430626090384954,0.0594835150674328,FALSE +"H3255","Pearson.est","serotonin receptor antagonist",-0.32922,-0.828,0.663,1048,0.949,"RS.16566, sertindole, ziprasidone, SB.228357",0.178486471595227,0.0227337875727074,FALSE +"H3255","Pearson.est","sodium channel blocker",0.39238,1.05,0.377,66,0.827,"oxcarbazepine, benzethonium, cibenzoline",0.423658649794207,0.0824944904474534,FALSE +"H3255","Pearson.est","src inhibitor",-0.36674,-0.907,0.577,1112,0.958,"TG.100572, KX2.391, saracatinib",0.238824186844269,0.0186344909214556,FALSE +"H3255","Pearson.est","sterol demethylase inhibitor",0.56571,1.53,0.0803,114,0.585,"sulconazole, posaconazole, terconazole",1.09528445472132,0.23284413391782,FALSE +"H3255","Pearson.est","TGF beta receptor inhibitor",-0.38004,-0.943,0.529,1040,0.911,"repsox, D.4476, LY2109761",0.276544327964814,0.0404816230270017,FALSE +"H3255","Pearson.est","thymidylate synthase inhibitor",-0.64127,-1.61,0.0563,1288,0.702,"carmofur, raltitrexed, doxifluridine",1.24949160514865,0.153662887870195,FALSE +"H3255","Pearson.est","topoisomerase inhibitor",-0.57679,-1.41,0.113,1262,0.676,"nemorubicin, topotecan, licochalcone.a, rubitecan, SN.38, irinotecan, camptothecin, genz.644282, exatecan.mesylate",0.94692155651658,0.170053304058364,FALSE +"H3255","Pearson.est","tubulin polymerization inhibitor",-0.47778,-1.19,0.265,874,0.678,"epothilone.b, ABT.751, indibulin, albendazole, flubendazole, CYT.997, vinorelbine, vincristine, dolastatin.10, plinabulin, parbendazole, mebendazole, KX2.391, fosbretabulin, podophyllotoxin, taltobulin, combretastatin.A.4",0.576754126063192,0.168770306132937,FALSE +"H3255","Pearson.est","tyrosine kinase inhibitor",-0.30688,-0.74,0.778,1070,0.932,"hypericin, BMS.599626, CP.724714, AV.412, tyrphostin.A9, vandetanib, apatinib, tivantinib, bafetinib, AMG.208",0.109020403010311,0.0305840876460186,FALSE +"H3255","Pearson.est","VEGFR inhibitor",-0.27547,-0.671,0.849,952,0.96,"vatalanib, regorafenib, motesanib, foretinib, OSI.930, RAF265, telatinib, TG.100572, golvatinib, XL.647, BMS.690514, MGCD.265, vandetanib, lucitanib, orantinib, AEE788",0.0710923097560473,0.0177287669604316,FALSE +"H3255","Pearson.est","vitamin D receptor agonist",-0.43686,-1.07,0.397,1195,0.847,"maxacalcitol, calcitriol, ercalcitriol",0.401209493236885,0.0721165896692931,FALSE +"H358","Pearson.est","EGFR inhibitor",-0.58942,-1.48,0.0893,1173,0.631,"PD.168393, AEE788, OSI.420, ARRY.334543, BMS.690514, vandetanib, tucatinib, GW.583340, BIBU.1361, rociletinib, PD.153035, TAK.285, erlotinib, lapatinib, dacomitinib, canertinib, neratinib, tyrphostin.AG.1478, WZ8040, icotinib, gefitinib, osimertinib, pelitinib, afatinib",1.04914854111145,0.199970640755866,FALSE +"H358","Pearson.est","Abl kinase inhibitor",0.20667,0.569,0.932,361,1,"ponatinib, flumatinib, GZD824, ZM.306416, dasatinib",0.0305840876460186,0,FALSE +"H358","Pearson.est","acetylcholine receptor agonist",0.56734,1.54,0.0642,306,0.589,"xanomeline, nefiracetam",1.19246497193115,0.229884705212898,FALSE +"H358","Pearson.est","acetylcholine receptor antagonist",-0.43031,-1.07,0.371,1398,0.71,"dicycloverine",0.430626090384954,0.148741651280925,FALSE +"H358","Pearson.est","adenosine receptor antagonist",-0.52306,-1.3,0.202,1072,0.557,"sulmazole, theophylline, CGS.15943",0.694648630553376,0.254144804826271,FALSE +"H358","Pearson.est","adrenergic receptor agonist",-0.49634,-1.24,0.219,971,0.619,"methyldopa, epinephrine, midodrine, norepinephrine, oxymetazoline, metaraminol, clenbuterol, terbutaline, A61603, isoxsuprine",0.659555885159882,0.208309350979882,FALSE +"H358","Pearson.est","adrenergic receptor antagonist",-0.37035,-0.935,0.528,1305,0.849,"pindolol, vincamine, levobunolol, dronedarone",0.277366077466188,0.0710923097560473,FALSE +"H358","Pearson.est","AKT inhibitor",-0.47511,-1.21,0.229,1158,0.565,"CCT128930, palomid.529, ONC201, triciribine, uprosertib",0.640164517660112,0.247951552180562,FALSE +"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.29784,0.803,0.691,1020,1,"alectinib, brigatinib, DMH1, SB.505124, lorlatinib, AZD3463, NVP.TAE684, AP26113, GW.788388, CEP.37440, crizotinib",0.160521952625802,0,FALSE +"H358","Pearson.est","androgen receptor antagonist",-0.26608,-0.666,0.866,752,0.989,"enzalutamide, nilutamide, flutamide, bicalutamide, cyproterone.acetate",0.0624821079826534,0.0048037084028206,FALSE +"H358","Pearson.est","antioxidant",0.52226,1.41,0.118,10,0.629,"trolox",0.928117992693875,0.201349354554731,FALSE +"H358","Pearson.est","AP inhibitor",-0.41149,-1.03,0.425,931,0.738,"GDC.0152, tanshinone.i, LCL.161, embelin",0.371611069949688,0.131943638176958,FALSE +"H358","Pearson.est","ATPase inhibitor",0.64878,1.71,0.0362,106,0.389,"k.strophanthidin, oligomycin.a, NMS.873, blebbistatin....",1.44129142946683,0.410050398674292,FALSE +"H358","Pearson.est","Aurora kinase inhibitor",0.24466,0.645,0.856,481,1,"CYC116, CCT129202, AT.9283, barasertib.HQPA, PHA.680632, ENMD.2076, CCT137690, TAK.901, danusertib, SNS.314, GSK1070916, KW.2449, AMG900",0.0675262353228468,0,FALSE +"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.29415,0.783,0.719,24,1,"radezolid",0.143271109617117,0,FALSE +"H358","Pearson.est","bacterial DNA gyrase inhibitor",-0.34281,-0.881,0.602,1224,0.813,"trovafloxacin, lomefloxacin, sparfloxacin",0.220403508742175,0.0899094544059319,FALSE +"H358","Pearson.est","BCL inhibitor",0.22292,0.611,0.929,1127,1,"gossypol, ABT.737, TW.37, venetoclax, HA14.1, oridonin, navitoclax, obatoclax",0.0319842860063582,0,FALSE +"H358","Pearson.est","Bcr.Abl kinase inhibitor",0.18727,0.496,0.979,250,0.982,"ponatinib, flumatinib, GZD824",0.00921730819686218,0.00788851221305034,FALSE +"H358","Pearson.est","benzodiazepine receptor agonist",-0.21344,-0.53,0.958,765,1,"CL.218872, ZK.93423, temazepam, CGS.20625, indiplon, zaleplon",0.0186344909214556,0,FALSE +"H358","Pearson.est","bromodomain inhibitor",-0.65405,-1.63,0.0321,1172,0.39,"bromosporine, I.BET151, JQ1...., I.BET.762",1.49349496759513,0.408935392973501,FALSE +"H358","Pearson.est","calcium channel blocker",0.29852,0.814,0.677,178,1,"efonidipine.monoethanolate, carboxyamidotriazole, pranidipine",0.169411331314856,0,FALSE +"H358","Pearson.est","CC chemokine receptor antagonist",-0.33579,-0.854,0.624,1133,0.837,"PF.04136309, MK.0812, navarixin",0.204815410317576,0.07727454200674,FALSE +"H358","Pearson.est","CDK inhibitor",-0.38739,-0.954,0.502,962,0.865,"BMS.265246, TG.02, JNJ.7706621, AZD5438, dinaciclib, P276.00, BMS.387032, kenpaullone, PHA.793887, arcyriaflavin.a, alvocidib, CR8..R.",0.299296282854981,0.0629838925351858,FALSE +"H358","Pearson.est","CHK inhibitor",-0.54615,-1.38,0.137,787,0.58,"AZD7762, SB.218078, PF.477736, CHIR.124, LY2603618, SCH.900776, LY2606368",0.863279432843593,0.236572006437063,FALSE +"H358","Pearson.est","cyclooxygenase inhibitor",-0.20124,-0.514,0.981,963,1,"tryptanthrin, curcumin, amfenac, AM.404, meloxicam, indoprofen, ramifenazone, FK.3311",0.0083309926200515,0,FALSE +"H358","Pearson.est","cytochrome P450 inhibitor",0.19084,0.522,0.981,434,1,"eplerenone, morin, PF.4981517, metyrapone",0.0083309926200515,0,FALSE +"H358","Pearson.est","DNA alkylating agent",-0.54772,-1.38,0.135,1096,0.58,"dianhydrogalactitol, mitomycin.c, ifosfamide, estramustine, cisplatin, satraplatin, melphalan, dacarbazine",0.869666231504994,0.236572006437063,FALSE +"H358","Pearson.est","DNA inhibitor",0.32091,0.874,0.582,163,1,"carboplatin, oxaliplatin, mechlorethamine, metronidazole, teroxirone",0.235077015350112,0,FALSE +"H358","Pearson.est","DNA methyltransferase inhibitor",-0.71586,-1.82,0.00479,1425,0.507,"fdcyd, azacitidine",2.31966448658544,0.294992040666664,FALSE +"H358","Pearson.est","DNA polymerase inhibitor",-0.58173,-1.45,0.0963,917,0.566,"cephalomannine, adefovir.dipivoxil, trifluridine, cidofovir",1.01637371287547,0.247183568811729,FALSE +"H358","Pearson.est","DNA synthesis inhibitor",-0.32684,-0.796,0.689,1065,0.912,"anisomycin, mitomycin.c, floxuridine, altretamine, cisplatin",0.161780778092374,0.0400051616715838,FALSE +"H358","Pearson.est","dopamine receptor antagonist",-0.23506,-0.595,0.931,916,1,"mesoridazine, nemonapride, piperacetazine, ziprasidone, amisulpride, sertindole, acetophenazine, isofloxythepin",0.0310503190186574,0,FALSE +"H358","Pearson.est","estrogen receptor agonist",-0.35591,-0.894,0.569,1199,0.835,"equol, estradiol, PPT",0.244887733604929,0.0783135245163979,FALSE +"H358","Pearson.est","estrogen receptor antagonist",-0.29569,-0.741,0.784,1020,0.953,"toremifene, raloxifene",0.105683937315562,0.0209070993616736,FALSE +"H358","Pearson.est","FGFR inhibitor",0.43707,1.19,0.254,112,0.687,"AZD4547, nintedanib, erdafitinib",0.595166283380062,0.16304326294045,FALSE +"H358","Pearson.est","FLT3 inhibitor",-0.18557,-0.468,0.978,1281,0.987,"tandutinib, pacritinib",0.00966114521239857,0.00568284733036327,FALSE +"H358","Pearson.est","glucocorticoid receptor agonist",0.67554,1.84,0.0265,162,0.303,"dexamethasone.acetate, hydrocortisone, desonide, beclomethasone.dipropionate, rimexolone, triamcinolone.acetonide, halcinonide, flumethasone.pivalate, fluticasone.propionate, triamcinolone, ciclesonide, deflazacort, fluocinolone.acetonide, betamethasone, clobetasol.propionate",1.57675412606319,0.518557371497695,FALSE +"H358","Pearson.est","glutamate receptor antagonist",-0.46099,-1.17,0.284,1343,0.589,"ACDPP, LY456236, diazooxonorleucine",0.546681659952962,0.229884705212898,FALSE +"H358","Pearson.est","glycogen synthase kinase inhibitor",-0.54895,-1.37,0.136,1270,0.558,"kenpaullone, GSK.3.inhibitor.IX, AZD2858",0.866461091629782,0.253365801062421,FALSE +"H358","Pearson.est","growth factor receptor inhibitor",0.42493,1.17,0.282,424,0.671,"PHA.848125, GSK1904529A, lestaurtinib, danusertib",0.549750891680639,0.173277479831008,FALSE +"H358","Pearson.est","HCV inhibitor",-0.58478,-1.46,0.101,1193,0.608,"daclatasvir, PSI.7976, Ro.9187, embelin",0.995678626217357,0.216096420727265,FALSE +"H358","Pearson.est","HDAC inhibitor",-0.47671,-1.2,0.246,1028,0.558,"dacinostat, trichostatin.a, givinostat, romidepsin, M.344, entinostat, tacedinaline, R306465, vorinostat, PCI.24781, panobinostat, SB.939, JNJ.26481585",0.609064892896621,0.253365801062421,FALSE +"H358","Pearson.est","histamine receptor antagonist",-0.54955,-1.38,0.126,964,0.58,"cimetidine, lafutidine, nizatidine, astemizole, cyproheptadine, terfenadine, tecastemizole, tiotidine, levocetirizine, zolantidine, chloropyramine",0.899629454882437,0.236572006437063,FALSE +"H358","Pearson.est","HMGCR inhibitor",0.26008,0.715,0.792,207,1,"lovastatin, pitavastatin",0.101274818410506,0,FALSE +"H358","Pearson.est","HSP inhibitor",-0.45862,-1.15,0.294,828,0.579,"SNX.5422, SNX.2112, ganetespib, tanespimycin, PU.H71, KW.2478, guanidine, XL888, BIIB021, alvespimycin, NVP.AUY922, VER.49009",0.531652669587843,0.237321436272564,FALSE +"H358","Pearson.est","JAK inhibitor",-0.37185,-0.92,0.565,1391,0.807,"pacritinib, LY2784544, atiprimod",0.247951552180562,0.0931264652779296,FALSE +"H358","Pearson.est","KIT inhibitor",-0.30976,-0.765,0.74,1203,0.939,"imatinib, tandutinib, telatinib",0.130768280269024,0.0273344077338891,FALSE +"H358","Pearson.est","MDM inhibitor",0.69494,1.91,0.011,417,0.4,"AMG.232, idasanutlin, nutlin.3, RITA, serdemetan",1.95860731484178,0.397940008672038,FALSE +"H358","Pearson.est","MEK inhibitor",-0.37332,-0.923,0.526,1440,0.848,"nobiletin, BIX.02188",0.279014255846261,0.0716041477432862,FALSE +"H358","Pearson.est","MET inhibitor",-0.69648,-1.74,0.0162,1110,0.46,"NVP.BVU972, LY2801653, AMG458, INC.280",1.79048498545737,0.337242168318426,FALSE +"H358","Pearson.est","microtubule inhibitor",0.30598,0.841,0.615,1008,1,"vinblastine, cytochalasin.b, estramustine.phosphate, secnidazole, vinflunine, colchicine, D.64131, cabazitaxel, podophyllotoxin, triclabendazole",0.211124884224583,0,FALSE +"H358","Pearson.est","mTOR inhibitor",0.33804,0.928,0.484,341,1,"SB.2343, torin.1, PF.04691502, AZD2014, PKI.179, WYE.125132, MLN0128, XL388, OSI.027, deforolimus, WYE.354, voxtalisib",0.315154638355588,0,FALSE +"H358","Pearson.est","NFkB pathway inhibitor",-0.27633,-0.685,0.83,910,0.988,"bindarit, parthenolide, parthenolide...., curcumin, IKK.2.inhibitor.V, Ro.106.9920, bortezomib",0.0809219076239261,0.00524305541237188,FALSE +"H358","Pearson.est","opioid receptor agonist",-0.68891,-1.71,0.0238,1439,0.384,"salvinorin.a",1.62342304294349,0.415668775632469,FALSE +"H358","Pearson.est","p38 MAPK inhibitor",-0.54581,-1.36,0.146,847,0.541,"skepinone.l, SB.239063, VX.702, CMPD.1, TAK.715",0.835647144215563,0.266802734893431,FALSE +"H358","Pearson.est","PARP inhibitor",-0.5201,-1.29,0.189,1042,0.546,"talazoparib, olaparib, PJ.34, niraparib",0.723538195826756,0.262807357295263,FALSE +"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.21037,-0.526,0.967,1203,1,"imatinib, tandutinib, telatinib, trapidil",0.0145735259169983,0,FALSE +"H358","Pearson.est","phosphatase inhibitor",0.3071,0.837,0.638,85,1,"GSK2830371, bis.maltolato.oxovanadium.IV.",0.195179321278838,0,FALSE +"H358","Pearson.est","phosphodiesterase inhibitor",-0.45876,-1.15,0.292,1226,0.579,"zardaverine, YM.976, cilostamide",0.534617148551582,0.237321436272564,FALSE +"H358","Pearson.est","PI3K inhibitor",0.22834,0.625,0.892,188,1,"ZSTK.474, SB.2343, GDC.0941, idelalisib, PF.04691502, PI.828",0.0496351456238769,0,FALSE +"H358","Pearson.est","PLK inhibitor",0.44627,1.19,0.262,437,0.687,"NMS.1286937, volasertib, HMN.214, rigosertib",0.581698708680255,0.16304326294045,FALSE +"H358","Pearson.est","potassium channel blocker",-0.3801,-0.951,0.506,990,0.843,"meglitinide, oleoylethanolamide, dofetilide",0.295849483160201,0.0741724253752577,FALSE +"H358","Pearson.est","PPAR receptor agonist",0.44704,1.2,0.244,114,0.813,"fenofibrate, pterostilbene",0.612610173661271,0.0899094544059319,FALSE +"H358","Pearson.est","progesterone receptor agonist",0.50468,1.37,0.146,36,0.617,"tanaproget, norethindrone",0.835647144215563,0.209714835966758,FALSE +"H358","Pearson.est","proteasome inhibitor",-0.6937,-1.7,0.0203,1115,0.312,"ONX.0914, ixazomib, ixazomib.citrate, bortezomib, carfilzomib",1.69250396208679,0.505845405981557,FALSE +"H358","Pearson.est","protein synthesis inhibitor",0.21367,0.575,0.929,119,1,"clindamycin.phosphate, clofoctol",0.0319842860063582,0,FALSE +"H358","Pearson.est","protein tyrosine kinase inhibitor",0.37864,1.01,0.424,97,0.958,"mubritinib, PP.121",0.372634143407267,0.0186344909214556,FALSE +"H358","Pearson.est","RAF inhibitor",-0.52378,-1.34,0.139,965,0.546,"SB.590885, AZ.628, CEP.32496, GDC.0879, vemurafenib, dabrafenib",0.856985199745905,0.262807357295263,FALSE +"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.48529,-1.22,0.227,1214,0.572,"apatinib, vandetanib",0.643974142806877,0.242603971206976,FALSE +"H358","Pearson.est","retinoid receptor agonist",-0.48555,-1.23,0.215,1328,0.579,"AM.580, tamibarotene, CD.437",0.667561540084395,0.237321436272564,FALSE +"H358","Pearson.est","ribonucleotide reductase inhibitor",0.25586,0.678,0.83,197,1,"cytarabine, pentostatin, hydroxyurea",0.0809219076239261,0,FALSE +"H358","Pearson.est","serotonin receptor agonist",0.50283,1.42,0.118,280,0.729,"aripiprazole, NAN.190",0.928117992693875,0.137272471682025,FALSE +"H358","Pearson.est","serotonin receptor antagonist",-0.36624,-0.921,0.546,1102,0.828,"ziprasidone, lerisetron, SB.228357, sertindole, RS.16566",0.262807357295263,0.0819696632151199,FALSE +"H358","Pearson.est","sodium channel blocker",0.29604,0.791,0.685,135,1,"oxcarbazepine, benzethonium, A.803467, cibenzoline",0.164309428507574,0,FALSE +"H358","Pearson.est","src inhibitor",-0.35065,-0.884,0.61,1302,0.83,"PP.2, saracatinib",0.214670164989233,0.0809219076239261,FALSE +"H358","Pearson.est","sterol demethylase inhibitor",0.45751,1.29,0.201,360,0.696,"sulconazole, posaconazole, chlormidazole, terconazole",0.696803942579511,0.157390760389438,FALSE +"H358","Pearson.est","TGF beta receptor inhibitor",-0.53326,-1.33,0.173,1240,0.532,"D.4476, repsox, LY2109761",0.761953896871205,0.274088367704952,FALSE +"H358","Pearson.est","thymidylate synthase inhibitor",-0.62616,-1.57,0.0686,1046,0.459,"trifluridine, raltitrexed, carmofur, doxifluridine",1.16367588429325,0.338187314462739,FALSE +"H358","Pearson.est","topoisomerase inhibitor",-0.41908,-1.06,0.377,1251,0.705,"SN.38, camptothecin, irinotecan, licochalcone.a, genz.644282, exatecan.mesylate",0.423658649794207,0.151810883008601,FALSE +"H358","Pearson.est","tubulin polymerization inhibitor",-0.20919,-0.53,0.974,704,1,"parbendazole, vincristine, docetaxel, nocodazole, flubendazole, albendazole, indibulin, plinabulin, oxibendazole, epothilone.b, taltobulin, vinorelbine, podophyllotoxin, KX2.391, paclitaxel, fosbretabulin, epothilone.d, combretastatin.A.4",0.0114410431213845,0,FALSE +"H358","Pearson.est","tyrosine kinase inhibitor",-0.27884,-0.692,0.818,1058,1,"rheochrysidin, BMS.599626, CP.724714, tyrphostin.A9, apatinib, vandetanib, AV.412, tivantinib, AMG.208",0.087246696328677,0,FALSE +"H358","Pearson.est","VEGFR inhibitor",-0.20129,-0.496,0.988,1157,0.998,"lucitanib, AEE788, BMS.690514, vandetanib, golvatinib, telatinib, MGCD.265",0.00524305541237188,0.000869458712628891,FALSE +"H358","Pearson.est","vitamin D receptor agonist",-0.48833,-1.23,0.227,1230,0.579,"maxacalcitol, ercalcitriol, calcitriol",0.643974142806877,0.237321436272564,FALSE +"A549","Pearson.est","EGFR inhibitor",0.72123,1.83,0.0139,328,0.365,"pelitinib, tucatinib, dacomitinib, osimertinib, afatinib, CP.724714, AZD8931, canertinib, WZ8040, OSI.420, poziotinib, neratinib, erlotinib, icotinib, vandetanib, gefitinib, ARRY.334543, BMS.599626, BMS.690514, AEE788, AST.1306, rociletinib, PD.168393, CUDC.101, CNX.2006, PD.153035, XL.647, GW.583340, BIBU.1361, salvianolic.acid.B, lapatinib",1.8569851997459,0.437707135543525,FALSE +"A549","Pearson.est","Abl kinase inhibitor",0.33981,0.878,0.605,198,0.894,"ZM.306416, imatinib, flumatinib",0.218244625347531,0.0486624812040823,FALSE +"A549","Pearson.est","acetylcholine receptor agonist",0.35494,0.931,0.515,71,0.904,"oxiracetam",0.288192770958809,0.0438315695246367,FALSE +"A549","Pearson.est","acetylcholine receptor antagonist",0.59753,1.55,0.078,451,0.388,"dicycloverine, darifenacin, diphemanil, hyoscyamine",1.10790539730952,0.411168274405793,FALSE +"A549","Pearson.est","adenosine receptor antagonist",0.68202,1.76,0.0199,455,0.389,"CGS.15943, MRS.1220, SCH.58261, PSB.1115, istradefylline, sulmazole",1.70114692359029,0.410050398674292,FALSE +"A549","Pearson.est","adrenergic receptor agonist",0.35495,0.925,0.512,226,0.885,"oxymetazoline, methyldopa, A61603, isoetharine",0.290730039024169,0.0530567293021746,FALSE +"A549","Pearson.est","adrenergic receptor antagonist",0.299,0.777,0.682,240,0.926,"atenolol...., RS.17053, dronedarone, pindolol, prazosin",0.166215625343521,0.0333890133180656,FALSE +"A549","Pearson.est","AKT inhibitor",0.41432,1.06,0.366,368,0.797,"CCT128930, uprosertib, palomid.529, GSK2110183, A.674563",0.436518914605589,0.0985416786038876,FALSE +"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.28314,-0.715,0.8,1081,1,"AZD3463, alectinib, lorlatinib, crizotinib",0.0969100130080564,0,FALSE +"A549","Pearson.est","androgen receptor antagonist",0.62025,1.57,0.0554,514,0.533,"cyproterone.acetate, nilutamide, flutamide, bicalutamide",1.25649023527157,0.273272790973428,FALSE +"A549","Pearson.est","antioxidant",-0.47403,-1.22,0.22,1062,0.54,"rutin, trolox, chlorogenic.acid, mesna",0.657577319177794,0.267606240177031,FALSE +"A549","Pearson.est","AP inhibitor",0.65323,1.65,0.0335,232,0.545,"embelin, tanshinone.i, LCL.161",1.47495519296315,0.263603497723358,FALSE +"A549","Pearson.est","ATPase inhibitor",-0.37192,-0.944,0.519,1258,0.864,"rabeprazole, digitoxigenin, oligomycin.a",0.284832642151542,0.0634862575211067,FALSE +"A549","Pearson.est","Aurora kinase inhibitor",-0.6688,-1.74,0.0245,1129,0.388,"SNS.314, barasertib, KW.2449, MLN.8054, alisertib, tozasertib, CCT137690, danusertib, AT.9283, TAK.901, PF.03814735, hesperadin, MK.8745, MK.5108, GSK1070916, AMG900",1.61083391563547,0.411168274405793,FALSE +"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.26181,0.686,0.831,1071,0.927,"tilmicosin, dirithromycin, josamycin, valnemulin, azalomycin.b, azithromycin, radezolid, tedizolid",0.080398976215889,0.0329202658555029,FALSE +"A549","Pearson.est","bacterial DNA gyrase inhibitor",-0.61641,-1.57,0.074,1306,0.302,"lomefloxacin, novobiocin, finafloxacin",1.13076828026902,0.519993057042849,FALSE +"A549","Pearson.est","BCL inhibitor",0.49789,1.31,0.188,272,0.613,"ABT.737, navitoclax, obatoclax",0.72584215073632,0.212539525481585,FALSE +"A549","Pearson.est","Bcr.Abl kinase inhibitor",-0.27889,-0.693,0.828,1270,1,"tozasertib, GZD824",0.0819696632151199,0,FALSE +"A549","Pearson.est","benzodiazepine receptor agonist",0.26481,0.672,0.849,564,0.925,"temazepam, piperazine, indiplon, CL.218872, gamma.aminobutyric.acid, ZK.93423, eprinomectin, CGS.20625",0.0710923097560473,0.0338582672609674,FALSE +"A549","Pearson.est","bromodomain inhibitor",-0.33645,-0.848,0.638,1354,0.887,"OTX015",0.195179321278838,0.0520763801682736,FALSE +"A549","Pearson.est","calcium channel blocker",0.28824,0.737,0.783,394,0.919,"SKF.96365, mibefradil, tetrandrine, efonidipine.monoethanolate, fendiline",0.106238237942057,0.0366844886138887,FALSE +"A549","Pearson.est","CC chemokine receptor antagonist",-0.50501,-1.26,0.201,1351,0.511,"UNBS.5162, ZK811752",0.696803942579511,0.291579099865287,FALSE +"A549","Pearson.est","CDK inhibitor",0.32859,0.839,0.631,69,0.891,"CR8..R., BMS.387032, TG.02, AT.7519, indirubin",0.199970640755866,0.0501222959631252,FALSE +"A549","Pearson.est","CHK inhibitor",0.48472,1.27,0.171,88,0.656,"PF.477736",0.767003889607846,0.18309616062434,FALSE +"A549","Pearson.est","cyclooxygenase inhibitor",-0.21706,-0.546,0.956,1005,0.986,"phenazone, meloxicam, amfenac, aspirin, metoxibutropate, suxibuzone, tepoxalin, curcumin, acetylsalicylsalicylic.acid",0.0195421077238999,0.0061230850587888,FALSE +"A549","Pearson.est","cytochrome P450 inhibitor",0.40507,1.02,0.421,196,0.813,"morin, itraconazole",0.375717904164332,0.0899094544059319,FALSE +"A549","Pearson.est","DNA alkylating agent",-0.31491,-0.793,0.701,1167,0.915,"TH.302, mitomycin.c, satraplatin, cyclophosphamide, carboplatin",0.154281982033341,0.0385789059335517,FALSE +"A549","Pearson.est","DNA inhibitor",-0.56682,-1.44,0.0987,1092,0.415,"oxaliplatin, nimorazole, chlorambucil, sangivamycin, tirapazamine, metronidazole, valrubicin, teroxirone, carboplatin",1.00568284733036,0.381951903287907,FALSE +"A549","Pearson.est","DNA methyltransferase inhibitor",-0.31782,-0.813,0.678,1255,0.916,"decitabine, disulfiram",0.168770306132937,0.0381045263321496,FALSE +"A549","Pearson.est","DNA polymerase inhibitor",0.26221,0.67,0.841,381,0.907,"menadione, famciclovir, adefovir.dipivoxil, cidofovir",0.0752040042020878,0.0423927129399047,FALSE +"A549","Pearson.est","DNA synthesis inhibitor",-0.40422,-1.03,0.412,1014,0.773,"nelarabine, CB.10.277, azodicarbonamide, altretamine, artemisinin, mitomycin.c, cyclocytidine, floxuridine, artesunate",0.385102783966865,0.111820506081675,FALSE +"A549","Pearson.est","dopamine receptor antagonist",-0.22396,-0.567,0.946,1114,1,"oxiperomide, amisulpride, raclopride, domperidone, thioproperazine",0.0241088635982073,0,FALSE +"A549","Pearson.est","estrogen receptor agonist",-0.23853,-0.591,0.926,1050,1,"levonorgestrel, estradiol.cypionate, estrone",0.0333890133180656,0,FALSE +"A549","Pearson.est","estrogen receptor antagonist",0.34222,0.902,0.549,66,0.903,"tamoxifen",0.260427655549908,0.0443122496864942,FALSE +"A549","Pearson.est","FGFR inhibitor",0.60415,1.58,0.063,276,0.612,"orantinib, PD.173074, erdafitinib, lenvatinib, lucitanib",1.20065945054642,0.213248577854439,FALSE +"A549","Pearson.est","FLT3 inhibitor",0.17547,0.458,0.992,301,0.991,"TG.02, pacritinib, tandutinib, TG.101348",0.00348832784582135,0.00392634551472468,FALSE +"A549","Pearson.est","glucocorticoid receptor agonist",-0.25454,-0.647,0.867,1017,1,"prednisolone.hemisuccinate, halobetasol.propionate, beclomethasone.dipropionate, fluocinolone.acetonide, ciclesonide, dexamethasone.acetate, desonide, triamcinolone, prednisolone, fluticasone.propionate",0.0619809025237897,0,FALSE +"A549","Pearson.est","glutamate receptor antagonist",0.57282,1.46,0.107,475,0.514,"LY456236, CPP, MTPG, kynurenic.acid, JNJ.16259685, diazooxonorleucine, ACDPP, felbamate, latrepirdine, IEM1754",0.97061622231479,0.289036881004724,FALSE +"A549","Pearson.est","glycogen synthase kinase inhibitor",0.23578,0.594,0.919,69,0.943,"indirubin",0.0366844886138887,0.0254883072626717,FALSE +"A549","Pearson.est","growth factor receptor inhibitor",-0.51857,-1.3,0.195,1081,0.481,"AZD3463, lestaurtinib, danusertib, PHA.848125",0.709965388637482,0.317854923626168,FALSE +"A549","Pearson.est","HCV inhibitor",0.44975,1.17,0.261,57,0.667,"embelin",0.583359492661719,0.175874166083451,FALSE +"A549","Pearson.est","HDAC inhibitor",0.27616,0.737,0.797,458,0.919,"pyroxamide, nexturastat.a, SB.939, vorinostat, R306465, M.344, panobinostat, JNJ.26481585, belinostat",0.0985416786038876,0.0366844886138887,FALSE +"A549","Pearson.est","histamine receptor antagonist",0.56549,1.44,0.093,416,0.495,"chloropyramine, tecastemizole, ICI.162846, tiotidine, epinastine, cimetidine, astemizole, cyproheptadine, levocetirizine, nizatidine, BF2.649, terfenadine",1.03151705144606,0.305394801066431,FALSE +"A549","Pearson.est","HMGCR inhibitor",-0.68557,-1.72,0.0291,1174,0.299,"fluvastatin, pitavastatin, simvastatin",1.53610701101409,0.52432881167557,FALSE +"A549","Pearson.est","HSP inhibitor",0.27416,0.703,0.794,302,0.926,"alvespimycin, XL888, KW.2478, guanidine, tanespimycin, VER.49009",0.100179497572904,0.0333890133180656,FALSE +"A549","Pearson.est","JAK inhibitor",0.27623,0.724,0.775,301,0.917,"TG.02, LY2784544, AZD1480, pacritinib, atiprimod, TG.101348",0.11069829749369,0.0376306643299789,FALSE +"A549","Pearson.est","KIT inhibitor",0.43561,1.15,0.271,281,0.674,"imatinib, cediranib, motesanib, pazopanib, lenvatinib, tandutinib",0.567030709125594,0.17134010346468,FALSE +"A549","Pearson.est","MDM inhibitor",-0.60744,-1.6,0.0625,958,0.301,"AMG.232, RITA, nutlin.3, serdemetan, idasanutlin",1.20411998265592,0.521433504406157,FALSE +"A549","Pearson.est","MEK inhibitor",-0.56026,-1.42,0.112,1228,0.401,"PD.198306, MEK162, trametinib, AZD8330, PD.184352, PD.318088, PD.0325901, PD.98059, Ro.4987655, refametinib",0.950781977329818,0.396855627379818,FALSE +"A549","Pearson.est","MET inhibitor",-0.37787,-0.96,0.48,905,0.874,"NVP.BVU972, LY2801653, PHA.665752, PF.04217903",0.318758762624413,0.058488567365597,FALSE +"A549","Pearson.est","microtubule inhibitor",-0.42796,-1.09,0.354,1122,0.694,"vinflunine, cabazitaxel, D.64131, secnidazole, vinblastine",0.450996737974212,0.158640529545145,FALSE +"A549","Pearson.est","mTOR inhibitor",-0.58952,-1.5,0.0827,1084,0.364,"sirolimus, PI.103, voxtalisib, WYE.125132, AZD2014, XL388, GDC.0980, OSI.027, NVP.BEZ235, PF.04691502, MLN0128, PKI.179, LY303511, GSK2126458, torin.1, ku.0063794, PP242, SB.2343",1.08249449044745,0.438898616350944,FALSE +"A549","Pearson.est","NFkB pathway inhibitor",0.37134,0.96,0.499,365,0.909,"parthenolide, Ro.106.9920, tyloxapol, bortezomib, bindarit, IKK.2.inhibitor.V",0.30189945437661,0.0414361167780325,FALSE +"A549","Pearson.est","opioid receptor agonist",-0.33856,-0.864,0.617,1177,0.895,"spiradoline, BW.180C",0.209714835966758,0.048176964684088,FALSE +"A549","Pearson.est","p38 MAPK inhibitor",0.23144,0.598,0.907,453,0.96,"SB.242235, TAK.715, skepinone.l, SB.239063",0.0423927129399047,0.0177287669604316,FALSE +"A549","Pearson.est","PARP inhibitor",-0.36373,-0.935,0.521,986,0.801,"AZD2461, AG.14361, niraparib, talazoparib, olaparib",0.283162276700476,0.0963674839157623,FALSE +"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.38589,1.04,0.398,313,0.806,"orantinib, imatinib, motesanib, pazopanib, lenvatinib, tandutinib, linifanib",0.400116927926312,0.0936649581949093,FALSE +"A549","Pearson.est","phosphatase inhibitor",0.30618,0.78,0.707,194,0.946,"BVT.948, menadione, mycophenolate.mofetil",0.150580586203101,0.0241088635982073,FALSE +"A549","Pearson.est","phosphodiesterase inhibitor",0.368,0.939,0.513,399,0.919,"cilostamide, anagrelide, avanafil, enoximone",0.289882634888184,0.0366844886138887,FALSE +"A549","Pearson.est","PI3K inhibitor",-0.55838,-1.41,0.133,1052,0.381,"PI3K.IN.2, PIK.75, PI.103, voxtalisib, CH5132799, GDC.0980, NVP.BEZ235, PF.04691502, ZSTK.474, PKI.179, LY303511, GSK2126458, buparlisib, GDC.0941, YM.201636, SB.2343",0.876148359032914,0.419075024324381,FALSE +"A549","Pearson.est","PLK inhibitor",-0.71681,-1.83,0.0133,1131,0.419,"rigosertib, volasertib, GSK461364, NMS.1286937, HMN.214, GW.843682X",1.87614835903291,0.377785977033705,FALSE +"A549","Pearson.est","potassium channel blocker",0.34231,0.865,0.608,417,0.892,"dofetilide, oleoylethanolamide, mepivacaine",0.216096420727265,0.0496351456238769,FALSE +"A549","Pearson.est","PPAR receptor agonist",0.45959,1.2,0.251,308,0.644,"S26948, GW.501516, oleoylethanolamide",0.600326278518962,0.191114132640188,FALSE +"A549","Pearson.est","progesterone receptor agonist",-0.21404,-0.533,0.959,1000,0.964,"nomegestrol.acetate, levonorgestrel, norethindrone, tanaproget",0.0181813928293364,0.0159229660971692,FALSE +"A549","Pearson.est","proteasome inhibitor",0.30516,0.768,0.732,442,0.918,"carfilzomib, bortezomib, ixazomib.citrate, oprozomib",0.135488918941608,0.0371573187987575,FALSE +"A549","Pearson.est","protein synthesis inhibitor",-0.36886,-0.937,0.522,1079,0.835,"anguidine, thiostrepton, methacycline, chloramphenicol.palmitate, harringtonine, mercaptopurine, cycloheximide",0.282329496997738,0.0783135245163979,FALSE +"A549","Pearson.est","protein tyrosine kinase inhibitor",0.54388,1.39,0.149,341,0.546,"CP.724714, BMS.599626, AV.412, rheochrysidin",0.826813731587726,0.262807357295263,FALSE +"A549","Pearson.est","RAF inhibitor",0.53018,1.34,0.161,93,0.599,"dabrafenib, GDC.0879, CEP.32496",0.79317412396815,0.222573177610689,FALSE +"A549","Pearson.est","RET tyrosine kinase inhibitor",0.32054,0.819,0.657,74,0.902,"vandetanib",0.182434630440219,0.0447934624580583,FALSE +"A549","Pearson.est","retinoid receptor agonist",0.46293,1.22,0.226,298,0.637,"adarotene, tamibarotene, fenretinide, CD.437",0.645891560852599,0.19586056766465,FALSE +"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.52984,-1.35,0.164,1012,0.433,"triapine, gemcitabine, fludarabine.phosphate, clofarabine, cladribine, fludarabine, hydroxyurea",0.785156151952302,0.363512103646635,FALSE +"A549","Pearson.est","serotonin receptor agonist",0.6162,1.56,0.0735,1,0.417,"aripiprazole",1.1337126609158,0.379863945026242,FALSE +"A549","Pearson.est","serotonin receptor antagonist",0.60926,1.56,0.0655,117,0.417,"aripiprazole, lurasidone, lerisetron",1.18375870000822,0.379863945026242,FALSE +"A549","Pearson.est","sodium channel blocker",-0.24901,-0.63,0.908,1260,1,"oxcarbazepine, butamben, benzocaine",0.0419141514789149,0,FALSE +"A549","Pearson.est","src inhibitor",0.49786,1.26,0.209,364,0.634,"ZM.306416, saracatinib, PP.1, TG.100572, PP.2",0.679853713888946,0.197910742118267,FALSE +"A549","Pearson.est","sterol demethylase inhibitor",-0.68318,-1.7,0.0238,1375,0.255,"chlormidazole, lanoconazole",1.62342304294349,0.593459819566045,FALSE +"A549","Pearson.est","TGF beta receptor inhibitor",0.77207,1.99,0.00213,177,0.205,"SB.431542, LY2109761, repsox, D.4476",2.67162039656126,0.688246138944246,TRUE +"A549","Pearson.est","thymidylate synthase inhibitor",0.4285,1.08,0.341,133,0.789,"doxifluridine, capecitabine",0.467245621007502,0.10292299679058,FALSE +"A549","Pearson.est","topoisomerase inhibitor",-0.64381,-1.6,0.064,1135,0.301,"genz.644282, topotecan, nemorubicin, teniposide, rubitecan, SN.38, etoposide, amonafide, valrubicin, idarubicin, TAS.103, epirubicin, doxorubicin, voreloxin, mitoxantrone, amsacrine",1.19382002601611,0.521433504406157,FALSE +"A549","Pearson.est","tubulin polymerization inhibitor",-0.45473,-1.15,0.294,1093,0.62,"KX2.391, taltobulin, fenbendazole, epothilone.b, oxibendazole, vinblastine, mebendazole, verubulin, BNC105",0.531652669587843,0.207608310501746,FALSE +"A549","Pearson.est","tyrosine kinase inhibitor",0.34235,0.882,0.581,231,0.914,"CP.724714, vandetanib, hypericin, BMS.599626, tivantinib, AV.412",0.235823867609669,0.0390538042661686,FALSE +"A549","Pearson.est","VEGFR inhibitor",0.47334,1.23,0.251,277,0.655,"orantinib, ZM.306416, golvatinib, cediranib, PD.173074, vandetanib, motesanib, BMS.690514, AEE788, pazopanib, lenvatinib, XL.647, lucitanib, TG.100572",0.600326278518962,0.183758700008217,FALSE +"A549","Pearson.est","vitamin D receptor agonist",0.3308,0.847,0.626,386,0.902,"paricalcitol, tacalcitol, alfacalcidol",0.20342566678957,0.0447934624580583,FALSE +"HCC15","Pearson.est","EGFR inhibitor",-0.36413,-0.96,0.472,1143,0.919,"GW.583340, salvianolic.acid.B, pelitinib, BIBU.1361, PD.153035, XL.647, tyrphostin.AG.1478, icotinib, gefitinib, CNX.2006, BIBX.1382, OSI.420, erlotinib, vandetanib, rociletinib, PD.168393, WZ8040, CGP.52411",0.326058001365912,0.0366844886138887,FALSE +"HCC15","Pearson.est","Abl kinase inhibitor",-0.24164,-0.642,0.872,347,0.98,"flumatinib, bafetinib, nilotinib, imatinib, metatinib, KW.2449, GZD824, tozasertib, ZM.306416, ponatinib, bosutinib, dasatinib",0.0594835150674328,0.00877392430750515,FALSE +"HCC15","Pearson.est","acetylcholine receptor agonist",0.62991,1.57,0.0553,143,0.677,"xanomeline, oxiracetam, tremorine",1.2572748686953,0.169411331314856,FALSE +"HCC15","Pearson.est","acetylcholine receptor antagonist",0.45068,1.14,0.301,762,0.723,"hyoscyamine, dicycloverine, iododexetimide, diphemanil, darifenacin",0.521433504406157,0.140861702705469,FALSE +"HCC15","Pearson.est","adenosine receptor antagonist",0.25125,0.643,0.885,473,0.918,"MRS.1220, PSB.1115, sulmazole",0.0530567293021746,0.0371573187987575,FALSE +"HCC15","Pearson.est","adrenergic receptor agonist",0.19407,0.495,0.975,286,0.998,"ritodrine, lidamidine, clenbuterol",0.0109953843014632,0.000869458712628891,FALSE +"HCC15","Pearson.est","adrenergic receptor antagonist",-0.20058,-0.546,0.968,1224,1,"pindolol, levobunolol, metoprolol, imiloxan",0.0141246426916063,0,FALSE +"HCC15","Pearson.est","AKT inhibitor",-0.33437,-0.902,0.554,1105,0.944,"triciribine, GSK2110183, CCT128930, AT7867",0.25649023527157,0.025028005701931,FALSE +"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.3834,-1.04,0.408,1239,0.992,"GW.788388, alectinib, AP26113, lorlatinib",0.38933983691012,0.00348832784582135,FALSE +"HCC15","Pearson.est","androgen receptor antagonist",0.51074,1.25,0.221,611,0.69,"cyproterone.acetate, nilutamide, bicalutamide, enzalutamide, flutamide",0.655607726314889,0.161150909262745,FALSE +"HCC15","Pearson.est","antioxidant",-0.57358,-1.57,0.0568,1281,0.544,"rutin, benfotiamine, mesna",1.24565166428898,0.26440110030182,FALSE +"HCC15","Pearson.est","AP inhibitor",-0.40923,-1.12,0.314,1418,0.854,"embelin",0.503070351926785,0.068542129310995,FALSE +"HCC15","Pearson.est","ATPase inhibitor",0.55867,1.39,0.124,224,0.803,"k.strophanthidin, evodiamine, NMS.873, digoxin, digitoxin",0.906578314837765,0.095284454721319,FALSE +"HCC15","Pearson.est","Aurora kinase inhibitor",-0.36737,-1.01,0.392,1108,0.922,"MK.8745, PF.03814735, AT.9283, CCT129202, barasertib.HQPA, TAK.901, GSK1070916, hesperadin, MLN.8054, CYC116",0.406713932979543,0.0352690789463706,FALSE +"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.36783,0.917,0.542,618,0.848,"dirithromycin, josamycin, azithromycin, tedizolid, tilmicosin, azalomycin.b",0.266000713461613,0.0716041477432862,FALSE +"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.3331,0.837,0.672,155,0.852,"norfloxacin, sarafloxacin",0.172630726946175,0.0695604052332999,FALSE +"HCC15","Pearson.est","BCL inhibitor",0.56175,1.39,0.108,578,0.803,"TW.37, oridonin, HA14.1, venetoclax, ABT.737, gossypol",0.96657624451305,0.095284454721319,FALSE +"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",-0.24131,-0.656,0.868,347,1,"flumatinib, bafetinib, nilotinib, imatinib, metatinib, GZD824, tozasertib, ponatinib, bosutinib, dasatinib",0.0614802748235081,0,FALSE +"HCC15","Pearson.est","benzodiazepine receptor agonist",0.43467,1.09,0.364,389,0.711,"temazepam, ZK.93423, indiplon, bentazepam, piperazine",0.438898616350944,0.148130399270234,FALSE +"HCC15","Pearson.est","bromodomain inhibitor",0.54202,1.35,0.152,591,0.694,"PFI.1, JQ1...., bromosporine, I.BET151",0.818156412055227,0.158640529545145,FALSE +"HCC15","Pearson.est","calcium channel blocker",0.51064,1.29,0.174,409,0.686,"fendiline, carboxyamidotriazole, tetrandrine, pranidipine, SKF.96365, efonidipine.monoethanolate",0.7594507517174,0.163675884293248,FALSE +"HCC15","Pearson.est","CC chemokine receptor antagonist",0.31104,0.774,0.704,580,0.868,"UNBS.5162, SB.225002, ZK811752, PF.04136309, MK.0812",0.152427340857888,0.0614802748235081,FALSE +"HCC15","Pearson.est","CDK inhibitor",-0.1715,-0.451,0.992,1176,0.992,"R547, aminopurvalanol.a, NU6027, palbociclib, ribociclib",0.00348832784582135,0.00348832784582135,FALSE +"HCC15","Pearson.est","CHK inhibitor",0.4669,1.16,0.274,533,0.749,"PF.477736, LY2606368, SB.218078, CHIR.124, LY2603618",0.562249437179612,0.125518182300534,FALSE +"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.35169,-0.941,0.532,1115,0.908,"curcumin, acetylsalicylsalicylic.acid, meloxicam, indoprofen, tryptanthrin, amfenac, pterostilbene",0.274088367704952,0.0419141514789149,FALSE +"HCC15","Pearson.est","cytochrome P450 inhibitor",0.41495,1.03,0.432,716,0.752,"itraconazole, eplerenone, morin, metyrapone, PF.4981517",0.364516253185088,0.123782159408358,FALSE +"HCC15","Pearson.est","DNA alkylating agent",-0.29573,-0.827,0.673,1288,0.916,"streptozotocin, cyclophosphamide, TH.302, dianhydrogalactitol",0.171984935776023,0.0381045263321496,FALSE +"HCC15","Pearson.est","DNA inhibitor",0.30675,0.777,0.716,487,0.883,"mechlorethamine, valrubicin, teroxirone, metronidazole, sangivamycin, primaquine, melphalan, bendamustine",0.145086977692144,0.0540392964224314,FALSE +"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.4311,1.08,0.387,298,0.704,"SGI.1027, decitabine",0.412289034981089,0.152427340857888,FALSE +"HCC15","Pearson.est","DNA polymerase inhibitor",0.43599,1.1,0.343,346,0.719,"trifluridine, idoxuridine, menadione",0.464705879957229,0.143271109617117,FALSE +"HCC15","Pearson.est","DNA synthesis inhibitor",0.28756,0.712,0.834,403,0.858,"azodicarbonamide, artesunate, floxuridine, mitomycin.c, enocitabine",0.0788339493622613,0.0665127121512946,FALSE +"HCC15","Pearson.est","dopamine receptor antagonist",-0.47472,-1.28,0.182,1277,0.586,"clebopride, amisulpride, remoxipride, acetophenazine, oxiperomide",0.739928612014925,0.232102383981909,FALSE +"HCC15","Pearson.est","estrogen receptor agonist",-0.29412,-0.806,0.683,1415,0.916,"PPT",0.165579296318467,0.0381045263321496,FALSE +"HCC15","Pearson.est","estrogen receptor antagonist",-0.28641,-0.78,0.709,413,0.924,"danazol, clomifene, toremifene, tamoxifen, raloxifene, fulvestrant",0.149353764816933,0.0343280287798933,FALSE +"HCC15","Pearson.est","FGFR inhibitor",0.5912,1.48,0.0759,433,0.843,"regorafenib, dovitinib, erdafitinib, nintedanib, lenvatinib, AZD4547",1.11975822410452,0.0741724253752577,FALSE +"HCC15","Pearson.est","FLT3 inhibitor",0.39599,0.987,0.47,448,0.812,"dovitinib, sorafenib, GTP.14564, quizartinib, tandutinib, ENMD.2076, TG.101348",0.327902142064283,0.0904439707588247,FALSE +"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.19901,-0.543,0.972,1230,0.994,"hydrocortisone, dexamethasone.acetate, fluorometholone, fluticasone.propionate, prednisolone.acetate",0.0123337350737254,0.00261361560268669,FALSE +"HCC15","Pearson.est","glutamate receptor antagonist",-0.29938,-0.829,0.635,1313,0.956,"CPP, latrepirdine, SIB.1757",0.197226274708024,0.0195421077238999,FALSE +"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.28214,-0.762,0.726,406,0.915,"AZD2858, tideglusib, kenpaullone, GSK.3.inhibitor.IX, CHIR.99021, TWS.119, CHIR.98014, indirubin, LY2090314",0.139063379299906,0.0385789059335517,FALSE +"HCC15","Pearson.est","growth factor receptor inhibitor",0.30353,0.773,0.732,335,0.85,"GSK1838705A, PHA.848125",0.135488918941608,0.0705810742857073,FALSE +"HCC15","Pearson.est","HCV inhibitor",-0.47363,-1.28,0.191,1391,0.586,"Ro.9187, embelin",0.718966632752272,0.232102383981909,FALSE +"HCC15","Pearson.est","HDAC inhibitor",-0.35815,-0.994,0.422,1206,0.896,"chidamide, entinostat, romidepsin, tacedinaline, RG2833, mocetinostat, JNJ.26481585",0.374687549038326,0.0476919903378748,FALSE +"HCC15","Pearson.est","histamine receptor antagonist",-0.32487,-0.864,0.596,1300,0.977,"epinastine, levocetirizine, tiotidine, pheniramine",0.224753740259764,0.0101054362812269,FALSE +"HCC15","Pearson.est","HMGCR inhibitor",-0.53583,-1.47,0.0941,1193,0.445,"lovastatin, simvastatin",1.02641037657274,0.351639989019068,FALSE +"HCC15","Pearson.est","HSP inhibitor",0.54419,1.36,0.123,535,0.813,"SNX.2112, KW.2478, NMS.E973, SNX.5422, ganetespib, XL888, BIIB021, NVP.AUY922, PU.H71, guanidine",0.910094888560602,0.0899094544059319,FALSE +"HCC15","Pearson.est","JAK inhibitor",0.28935,0.723,0.809,191,0.88,"baricitinib, CEP.33779, AZD1480",0.0920514783877277,0.0555173278498314,FALSE +"HCC15","Pearson.est","KIT inhibitor",0.43859,1.1,0.342,376,0.719,"regorafenib, OSI.930, sorafenib, masitinib, pazopanib, tandutinib, lenvatinib, cediranib",0.465973893943865,0.143271109617117,FALSE +"HCC15","Pearson.est","MDM inhibitor",-0.81327,-2.26,0,1311,0.00618,"CGM097, idasanutlin, AMG.232, RITA",Inf,2.20901152491118,TRUE +"HCC15","Pearson.est","MEK inhibitor",-0.8304,-2.31,0,1305,0.00618,"PD.98059, U.0126, PD.198306, PD.0325901, PD.318088, MEK162, PD.184352, trametinib, TAK.733, AS.703026, cobimetinib, AZD8330, selumetinib, refametinib, Ro.4987655",Inf,2.20901152491118,TRUE +"HCC15","Pearson.est","MET inhibitor",-0.55433,-1.54,0.0981,1218,0.403,"INC.280, PHA.665752, PF.04217903",1.00833099262005,0.39469495385889,FALSE +"HCC15","Pearson.est","microtubule inhibitor",0.66901,1.66,0.0297,292,0.523,"colchicine, vinblastine, D.64131, vinflunine, podophyllotoxin, cabazitaxel",1.52724355068279,0.281498311132726,FALSE +"HCC15","Pearson.est","mTOR inhibitor",-0.47917,-1.33,0.175,1043,0.628,"torin.1, MLN0128, GSK2126458, LY3023414, temsirolimus, OSI.027, AZD8055, PF.04691502, NVP.BEZ235, SB.2343, GDC.0980, XL388, PF.05212384, sirolimus, WYE.354",0.756961951313706,0.202040356262804,FALSE +"HCC15","Pearson.est","NFkB pathway inhibitor",0.28784,0.722,0.795,203,0.863,"EVP4593, IKK.2.inhibitor.V, tyloxapol",0.0996328713435297,0.0639892042847904,FALSE +"HCC15","Pearson.est","opioid receptor agonist",0.29931,0.771,0.732,438,0.835,"cebranopadol, trimebutine, spiradoline, salvinorin.a",0.135488918941608,0.0783135245163979,FALSE +"HCC15","Pearson.est","p38 MAPK inhibitor",-0.24636,-0.679,0.868,355,1,"talmapimod, SB.242235, SB.239063, TAK.715, VX.702, skepinone.l, CMPD.1",0.0614802748235081,0,FALSE +"HCC15","Pearson.est","PARP inhibitor",-0.3662,-1.01,0.406,1243,0.922,"E7449, endo.IWR.1",0.391473966422806,0.0352690789463706,FALSE +"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.36222,0.901,0.568,345,0.854,"regorafenib, dovitinib, sorafenib, masitinib, pazopanib, nintedanib, tandutinib, lenvatinib, crenolanib",0.245651664288981,0.068542129310995,FALSE +"HCC15","Pearson.est","phosphatase inhibitor",0.52997,1.33,0.17,346,0.691,"CID.5458317, AS.1949490, GSK2830371, sodium.stibogluconate, menadione",0.769551078621726,0.160521952625802,FALSE +"HCC15","Pearson.est","phosphodiesterase inhibitor",0.35281,0.876,0.619,478,0.853,"avanafil, enoximone, cilostamide, EMD.53998",0.208309350979882,0.069050968832477,FALSE +"HCC15","Pearson.est","PI3K inhibitor",-0.30464,-0.836,0.66,1067,0.988,"GSK2126458, ZSTK.474, pilaralisib, LY3023414, alpelisib, PF.04691502, GDC.0941, CH5132799, NVP.BEZ235, SB.2343, GDC.0980, PF.05212384",0.180456064458131,0.00524305541237188,FALSE +"HCC15","Pearson.est","PLK inhibitor",0.78001,2,0.0016,324,0.0944,"volasertib, BI.2536, NMS.1286937, GW.843682X, HMN.214, rigosertib, GSK461364",2.79588001734407,1.02502800570193,TRUE +"HCC15","Pearson.est","potassium channel blocker",0.40497,1.05,0.382,230,0.738,"ML133, dofetilide",0.417936637088291,0.131943638176958,FALSE +"HCC15","Pearson.est","PPAR receptor agonist",-0.57239,-1.56,0.0669,1223,0.451,"GW.501516, clofibrate, fenofibrate, pterostilbene",1.17457388223218,0.345823458122039,FALSE +"HCC15","Pearson.est","progesterone receptor agonist",0.3415,0.87,0.62,558,0.84,"danazol, norethindrone, norethindrone.acetate, melengestrol.acetate",0.207608310501746,0.0757207139381184,FALSE +"HCC15","Pearson.est","proteasome inhibitor",0.38092,0.951,0.507,86,0.832,"MG.132",0.294992040666664,0.0798766737092761,FALSE +"HCC15","Pearson.est","protein synthesis inhibitor",0.52398,1.32,0.159,536,0.663,"puromycin, clofoctol, thiostrepton, homoharringtonine, harringtonine, bruceantin, methacycline, anguidine, chloramphenicol.palmitate, emetine, cycloheximide, tedizolid.phosphate",0.798602875679548,0.178486471595227,FALSE +"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.49482,1.24,0.201,201,0.673,"tyrphostin.A9, PP.121, mubritinib",0.696803942579511,0.171984935776023,FALSE +"HCC15","Pearson.est","RAF inhibitor",0.58151,1.46,0.0912,194,0.776,"regorafenib, SB.590885, RAF265, sorafenib, TAK.632",1.04000516167158,0.110138278741812,FALSE +"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.50405,1.28,0.184,118,0.664,"regorafenib, sorafenib",0.735182176990464,0.177831920631982,FALSE +"HCC15","Pearson.est","retinoid receptor agonist",0.47364,1.21,0.25,4,0.669,"adarotene",0.602059991327962,0.174573882232177,FALSE +"HCC15","Pearson.est","ribonucleotide reductase inhibitor",0.32445,0.823,0.677,519,0.833,"fludarabine.phosphate, triapine, LY2334737, cladribine, hydroxyurea, gemcitabine",0.169411331314856,0.0793549985932124,FALSE +"HCC15","Pearson.est","serotonin receptor agonist",0.45896,1.13,0.323,152,0.713,"pardoprunox, zolmitriptan",0.490797477668897,0.146910470148134,FALSE +"HCC15","Pearson.est","serotonin receptor antagonist",0.38837,0.979,0.482,453,0.801,"SB.200646, lerisetron, pirenperone, sertindole, tropisetron, lurasidone",0.31695296176115,0.0963674839157623,FALSE +"HCC15","Pearson.est","sodium channel blocker",0.19282,0.481,0.979,540,0.983,"brivaracetam, triamterene, benzethonium, A.803467, quinidine, ajmaline",0.00921730819686218,0.00744648216786438,FALSE +"HCC15","Pearson.est","src inhibitor",0.33909,0.84,0.645,232,0.868,"KX2.391, masitinib, TG.100572",0.190440285364732,0.0614802748235081,FALSE +"HCC15","Pearson.est","sterol demethylase inhibitor",0.35434,0.884,0.601,45,0.862,"chlormidazole",0.22112552799726,0.0644927341752872,FALSE +"HCC15","Pearson.est","TGF beta receptor inhibitor",0.32934,0.829,0.644,151,0.844,"LY2109761",0.191114132640188,0.073657553374345,FALSE +"HCC15","Pearson.est","thymidylate synthase inhibitor",0.52616,1.35,0.139,274,0.694,"trifluridine, raltitrexed, ftorafur",0.856985199745905,0.158640529545145,FALSE +"HCC15","Pearson.est","topoisomerase inhibitor",0.48646,1.22,0.231,225,0.68,"dexrazoxane, exatecan.mesylate, daunorubicin, epirubicin, topotecan, mitoxantrone, etoposide.phosphate, valrubicin, doxorubicin, SN.38",0.636388020107856,0.167491087293764,FALSE +"HCC15","Pearson.est","tubulin polymerization inhibitor",0.71873,1.8,0.0161,291,0.284,"vinorelbine, vindesine, taltobulin, vincristine, vinblastine, parbendazole, dolastatin.10, CYT.997, verubulin, BNC105, paclitaxel, KX2.391, fenbendazole, docetaxel, flubendazole, albendazole, oxibendazole, nocodazole, podophyllotoxin, fosbretabulin, ABT.751",1.79317412396815,0.546681659952962,FALSE +"HCC15","Pearson.est","tyrosine kinase inhibitor",0.44622,1.14,0.312,201,0.723,"tivantinib, regorafenib, tyrphostin.A9, hypericin, sorafenib, GTP.14564, PP.121, mubritinib",0.505845405981557,0.140861702705469,FALSE +"HCC15","Pearson.est","VEGFR inhibitor",0.37023,0.929,0.541,430,0.85,"regorafenib, RAF265, OSI.930, dovitinib, sorafenib, tivozanib, pazopanib, TG.100572, nintedanib, lenvatinib, cediranib, ENMD.2076, linifanib",0.266802734893431,0.0705810742857073,FALSE +"HCC15","Pearson.est","vitamin D receptor agonist",-0.70642,-2.01,0.014,1131,0.0721,"tacalcitol, calcitriol, paricalcitol, maxacalcitol, ercalcitriol, doxercalciferol",1.85387196432176,1.14206473528057,TRUE +"HCC44","Pearson.est","EGFR inhibitor",0.64323,1.82,0.0456,217,0.178,"tucatinib, CP.724714, AZD8931, GW.583340, dacomitinib, CNX.2006, canertinib, AEE788, poziotinib, neratinib, pelitinib, afatinib, ARRY.334543, BIBX.1382, BMS.690514, WZ8040, osimertinib, gefitinib, salvianolic.acid.B, PD.153035, OSI.420, vandetanib",1.34103515733556,0.749579997691106,TRUE +"HCC44","Pearson.est","Abl kinase inhibitor",-0.58323,-1.45,0.0879,1419,0.405,"tozasertib, KW.2449, GZD824",1.05601112492623,0.392544976785331,FALSE +"HCC44","Pearson.est","acetylcholine receptor agonist",-0.40719,-0.993,0.47,1175,0.935,"tremorine, nicotine",0.327902142064283,0.0291883891274822,FALSE +"HCC44","Pearson.est","acetylcholine receptor antagonist",0.85345,2.46,0,175,0.000534,"diphemanil, dicycloverine, iododexetimide, darifenacin",Inf,3.27245874297144,TRUE +"HCC44","Pearson.est","adenosine receptor antagonist",0.58032,1.6,0.0602,108,0.34,"CGS.15943, istradefylline, MRS.1220",1.22040350874218,0.468521082957745,FALSE +"HCC44","Pearson.est","adrenergic receptor agonist",-0.31782,-0.779,0.728,1038,0.982,"terbutaline, clenbuterol, norepinephrine, metaraminol, buphenine, epinephrine",0.137868620686963,0.00788851221305034,FALSE +"HCC44","Pearson.est","adrenergic receptor antagonist",0.35319,0.983,0.447,136,0.802,"RS.17053, prazosin, atenolol......, atenolol....",0.349692476868064,0.0958256317158365,FALSE +"HCC44","Pearson.est","AKT inhibitor",-0.31028,-0.749,0.781,1118,0.962,"ONC201, triciribine, GDC.0068",0.1073489661227,0.0168249279621871,FALSE +"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27038,-0.677,0.844,1304,0.956,"alectinib, crizotinib",0.073657553374345,0.0195421077238999,FALSE +"HCC44","Pearson.est","androgen receptor antagonist",-0.37646,-0.928,0.552,758,0.96,"flutamide, bicalutamide",0.258060922270801,0.0177287669604316,FALSE +"HCC44","Pearson.est","antioxidant",-0.73348,-1.8,0.0087,1294,0.122,"chlorogenic.acid, mesna",2.06048074738138,0.913640169325252,TRUE +"HCC44","Pearson.est","AP inhibitor",0.34876,0.977,0.47,219,0.719,"embelin, tanshinone.i",0.327902142064283,0.143271109617117,FALSE +"HCC44","Pearson.est","ATPase inhibitor",0.34749,0.943,0.471,74,0.742,"k.strophanthidin, blebbistatin....",0.326979092871104,0.129596094720973,FALSE +"HCC44","Pearson.est","Aurora kinase inhibitor",-0.74241,-1.82,0.0118,1270,0.137,"MLN.8054, danusertib, AT.9283, GSK1070916, barasertib, CCT137690, MK.8745, alisertib, SNS.314, tozasertib, MK.5108, KW.2449, AMG900, PF.03814735, hesperadin",1.92811799269387,0.863279432843593,TRUE +"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.33871,-0.828,0.67,1046,0.991,"josamycin, tedizolid",0.173925197299174,0.00392634551472468,FALSE +"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.73557,-1.86,0.00999,1348,0.138,"lomefloxacin, finafloxacin, novobiocin",2.00043451177402,0.860120913598763,TRUE +"HCC44","Pearson.est","BCL inhibitor",0.20903,0.579,0.954,1147,0.944,"ABT.737, obatoclax, gossypol, navitoclax, venetoclax, HA14.1, oridonin, TW.37",0.0204516252959049,0.025028005701931,FALSE +"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.55903,-1.39,0.116,1419,0.437,"tozasertib, GZD824",0.935542010773082,0.359518563029578,FALSE +"HCC44","Pearson.est","benzodiazepine receptor agonist",0.38778,1.1,0.295,126,0.783,"indiplon, temazepam, nefiracetam",0.530177984021837,0.106238237942057,FALSE +"HCC44","Pearson.est","bromodomain inhibitor",-0.60991,-1.51,0.0717,897,0.325,"bromosporine, PFI.1, JQ1...., OTX015, I.BET.762",1.1444808443322,0.488116639021126,FALSE +"HCC44","Pearson.est","calcium channel blocker",0.46806,1.3,0.152,401,0.576,"tetrandrine, fendiline, efonidipine.monoethanolate, mibefradil, SR.33805, SKF.96365, pranidipine",0.818156412055227,0.239577516576788,FALSE +"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.53902,-1.33,0.16,865,0.504,"MK.0812, RS.504393, navarixin, SB.225002, ZK811752, UNBS.5162",0.795880017344075,0.297569463554475,FALSE +"HCC44","Pearson.est","CDK inhibitor",-0.39735,-0.973,0.495,1122,0.95,"aminopurvalanol.a, palbociclib, indisulam, alvocidib, BMS.265246, PHA.848125, PHA.793887, abemaciclib, AZD5438, R547",0.305394801066431,0.0222763947111523,FALSE +"HCC44","Pearson.est","CHK inhibitor",0.30743,0.831,0.64,1005,0.723,"PF.477736, CHIR.124, AZD7762, SCH.900776, LY2603618, SB.218078, LY2606368",0.193820026016113,0.140861702705469,FALSE +"HCC44","Pearson.est","cyclooxygenase inhibitor",-0.26235,-0.648,0.879,959,0.932,"piroxicam, phenazone, indoprofen, ketoprofen, acetylsalicylsalicylic.acid, sulfasalazine, curcumin, meloxicam, ramifenazone, aspirin, suxibuzone",0.0560111249262281,0.0305840876460186,FALSE +"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.38228,-0.95,0.533,1110,0.972,"eplerenone, PF.4981517, cobicistat, clotrimazole",0.273272790973428,0.0123337350737254,FALSE +"HCC44","Pearson.est","DNA alkylating agent",-0.43285,-1.07,0.377,925,0.786,"satraplatin, dianhydrogalactitol, melphalan, mitomycin.c, carmustine, cyclophosphamide, TH.302, carboplatin",0.423658649794207,0.104577453960592,FALSE +"HCC44","Pearson.est","DNA inhibitor",-0.5732,-1.41,0.106,974,0.425,"sangivamycin, metronidazole, melphalan, nimorazole, carmustine, tirapazamine, chlorambucil, teroxirone, valrubicin, carboplatin",0.97469413473523,0.371611069949688,FALSE +"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.51204,-1.25,0.217,1221,0.59,"fdcyd, decitabine",0.66354026615147,0.229147988357856,FALSE +"HCC44","Pearson.est","DNA polymerase inhibitor",-0.31294,-0.773,0.752,1155,0.969,"idoxuridine, foscarnet, trifluridine",0.123782159408358,0.0136762229492347,FALSE +"HCC44","Pearson.est","DNA synthesis inhibitor",-0.37408,-0.921,0.555,1140,0.945,"mitomycin.c, CB.10.277, cyclocytidine, floxuridine",0.255707016877324,0.0245681914907371,FALSE +"HCC44","Pearson.est","dopamine receptor antagonist",-0.21005,-0.515,0.973,887,0.99,"ziprasidone, piperacetazine, domperidone, acetophenazine, UH.232...., isofloxythepin, oxiperomide, thioproperazine",0.0118871597316481,0.00436480540245009,FALSE +"HCC44","Pearson.est","estrogen receptor agonist",-0.45378,-1.14,0.301,916,0.719,"ethinyl.estradiol, PPT, estrone, estradiol, estradiol.cypionate",0.521433504406157,0.143271109617117,FALSE +"HCC44","Pearson.est","estrogen receptor antagonist",0.52762,1.51,0.0962,35,0.387,"tamoxifen",1.01682492796219,0.412289034981089,FALSE +"HCC44","Pearson.est","FGFR inhibitor",0.52348,1.45,0.108,90,0.405,"orantinib, lenvatinib, PD.173074",0.96657624451305,0.392544976785331,FALSE +"HCC44","Pearson.est","FLT3 inhibitor",-0.31902,-0.794,0.707,1138,1,"ENMD.2076, tandutinib, gilteritinib, tozasertib, KW.2449",0.150580586203101,0,FALSE +"HCC44","Pearson.est","glucocorticoid receptor agonist",0.36885,1.04,0.388,329,0.854,"triamcinolone.acetonide, hydrocortisone, deflazacort, flumethasone.pivalate, dexamethasone.acetate, piretanide, halcinonide, betamethasone, rimexolone, prednisolone.hemisuccinate",0.411168274405793,0.068542129310995,FALSE +"HCC44","Pearson.est","glutamate receptor antagonist",0.36542,1.02,0.396,325,0.834,"CGP.37849, MTPG, LY456236, CPP, kynurenic.acid",0.402304814074488,0.0788339493622613,FALSE +"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.3363,-0.819,0.684,909,0.984,"LY2090314, kenpaullone, CHIR.99021, tideglusib",0.164943898279884,0.00700490156865849,FALSE +"HCC44","Pearson.est","growth factor receptor inhibitor",-0.6127,-1.52,0.0725,1256,0.339,"PHA.848125, danusertib, GSK1838705A",1.13966199342901,0.469800301796918,FALSE +"HCC44","Pearson.est","HCV inhibitor",0.42602,1.18,0.249,144,0.748,"PSI.7976, embelin",0.603800652904264,0.126098402135539,FALSE +"HCC44","Pearson.est","HDAC inhibitor",-0.2267,-0.558,0.955,715,0.987,"M.344, mocetinostat, resminostat, romidepsin, tacedinaline, PCI.24781, RG2833, panobinostat, chidamide, AR.42, dacinostat, NSC.3852, entinostat, R306465, givinostat, trichostatin.a",0.0199966284162537,0.00568284733036327,FALSE +"HCC44","Pearson.est","histamine receptor antagonist",0.29831,0.832,0.63,335,0.753,"tecastemizole, chloropyramine, epinastine, ebastine, levocetirizine, famotidine, astemizole",0.200659450546418,0.123205023799299,FALSE +"HCC44","Pearson.est","HMGCR inhibitor",-0.36093,-0.874,0.603,976,0.984,"pitavastatin, fluvastatin, simvastatin",0.219682687859849,0.00700490156865849,FALSE +"HCC44","Pearson.est","HSP inhibitor",-0.45021,-1.12,0.326,1311,0.733,"SNX.2112, ganetespib, NVP.AUY922, BIIB021",0.486782399932061,0.134896025358872,FALSE +"HCC44","Pearson.est","JAK inhibitor",-0.28813,-0.706,0.811,1223,0.939,"baricitinib, AT.9283, tozasertib, WHI.P154",0.090979145788844,0.0273344077338891,FALSE +"HCC44","Pearson.est","KIT inhibitor",0.24595,0.678,0.857,190,0.918,"cediranib, lenvatinib, telatinib, motesanib",0.0670191780768018,0.0371573187987575,FALSE +"HCC44","Pearson.est","MDM inhibitor",-0.5871,-1.44,0.0937,1015,0.395,"serdemetan, CGM097, nutlin.3, idasanutlin",1.02826040911222,0.40340290437354,FALSE +"HCC44","Pearson.est","MEK inhibitor",-0.65731,-1.62,0.0386,1171,0.265,"PD.318088, PD.184352, PD.198306, MEK162, AS.703026, AZD8330, TAK.733, PD.98059, PD.0325901, cobimetinib, trametinib, Ro.4987655, refametinib",1.41341269532825,0.576754126063192,FALSE +"HCC44","Pearson.est","MET inhibitor",-0.66182,-1.6,0.0328,1306,0.263,"PHA.665752, LY2801653, PF.04217903",1.48412615628832,0.580044251510242,FALSE +"HCC44","Pearson.est","microtubule inhibitor",-0.3644,-0.903,0.601,952,0.954,"cytochalasin.b, cabazitaxel, secnidazole, vinflunine, D.64131, vinblastine",0.22112552799726,0.0204516252959049,FALSE +"HCC44","Pearson.est","mTOR inhibitor",-0.29421,-0.719,0.822,982,0.962,"GDC.0980, LY3023414, PI.103, AZD2014, GSK2126458, MLN0128, PP242, LY303511, ku.0063794, NVP.BEZ235",0.0851281824599496,0.0168249279621871,FALSE +"HCC44","Pearson.est","NFkB pathway inhibitor",0.35527,0.997,0.462,317,0.825,"tyloxapol, parthenolide, IKK.2.inhibitor.V, parthenolide...., bindarit",0.335358024443874,0.0835460514500749,FALSE +"HCC44","Pearson.est","opioid receptor agonist",-0.71455,-1.77,0.0115,1161,0.127,"trimebutine, spiradoline, BW.180C",1.93930215964639,0.896196279044043,TRUE +"HCC44","Pearson.est","p38 MAPK inhibitor",-0.47101,-1.18,0.274,1085,0.657,"talmapimod, VX.702, CMPD.1",0.562249437179612,0.182434630440219,FALSE +"HCC44","Pearson.est","PARP inhibitor",-0.5632,-1.38,0.126,1319,0.428,"niraparib, talazoparib, olaparib",0.899629454882437,0.368556230986828,FALSE +"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.23321,0.649,0.901,190,0.915,"orantinib, lenvatinib, telatinib, motesanib",0.045275209020937,0.0385789059335517,FALSE +"HCC44","Pearson.est","phosphatase inhibitor",0.33348,0.933,0.497,314,0.72,"mycophenolate.mofetil, menadione, GSK2830371, BVT.948",0.303643611266668,0.142667503568732,FALSE +"HCC44","Pearson.est","phosphodiesterase inhibitor",-0.15848,-0.395,0.996,1309,0.997,"EMD.53998",0.00174066157630127,0.00130484168834428,FALSE +"HCC44","Pearson.est","PI3K inhibitor",-0.355,-0.861,0.644,972,0.983,"CH5132799, GDC.0980, LY3023414, buparlisib, alpelisib, PI.103, PIK.75, GDC.0941, TG.100713, GSK2126458, LY303511, NVP.BEZ235",0.191114132640188,0.00744648216786438,FALSE +"HCC44","Pearson.est","PLK inhibitor",-0.70694,-1.76,0.0114,1226,0.114,"HMN.214, GSK461364, BI.2536, volasertib, GW.843682X",1.94309514866353,0.943095148663527,TRUE +"HCC44","Pearson.est","potassium channel blocker",-0.34117,-0.844,0.655,1336,0.988,"meglitinide",0.183758700008217,0.00524305541237188,FALSE +"HCC44","Pearson.est","PPAR receptor agonist",0.67702,1.9,0.0127,105,0.16,"S26948, GW.501516, pterostilbene",1.89619627904404,0.795880017344075,TRUE +"HCC44","Pearson.est","progesterone receptor agonist",0.31302,0.863,0.577,266,0.734,"norethindrone.acetate, levonorgestrel, norgestrel, norethindrone",0.238824186844269,0.134303940083929,FALSE +"HCC44","Pearson.est","proteasome inhibitor",-0.2669,-0.654,0.887,1072,0.944,"bortezomib, ixazomib",0.0520763801682736,0.025028005701931,FALSE +"HCC44","Pearson.est","protein synthesis inhibitor",-0.29408,-0.724,0.766,1370,0.976,"cycloheximide, mercaptopurine",0.115771230367396,0.0105501823333082,FALSE +"HCC44","Pearson.est","protein tyrosine kinase inhibitor",0.35373,0.977,0.442,324,0.719,"CP.724714, PP.121, AV.412, rheochrysidin",0.354577730650908,0.143271109617117,FALSE +"HCC44","Pearson.est","RAF inhibitor",-0.28573,-0.714,0.81,924,0.948,"SB.590885, vemurafenib, dabrafenib, RAF265, LGX818",0.0915149811213502,0.0231916626619338,FALSE +"HCC44","Pearson.est","RET tyrosine kinase inhibitor",-0.5007,-1.25,0.234,1375,0.59,"cabozantinib",0.630784142589857,0.229147988357856,FALSE +"HCC44","Pearson.est","retinoid receptor agonist",-0.4342,-1.07,0.382,1190,0.786,"tamibarotene, AM.580, adapalene",0.417936637088291,0.104577453960592,FALSE +"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.53561,-1.31,0.168,1225,0.517,"triapine, hydroxyurea, fludarabine, fludarabine.phosphate, clofarabine",0.774690718274137,0.286509456906058,FALSE +"HCC44","Pearson.est","serotonin receptor agonist",-0.31635,-0.78,0.753,1328,1,"SR.57227A",0.123205023799299,0,FALSE +"HCC44","Pearson.est","serotonin receptor antagonist",-0.37937,-0.943,0.552,1141,0.957,"SB.216641, pirenperone, RS.16566, SB.200646",0.258060922270801,0.0190880622231565,FALSE +"HCC44","Pearson.est","sodium channel blocker",-0.26716,-0.667,0.864,1083,0.948,"benzocaine, ajmaline, butamben",0.0634862575211067,0.0231916626619338,FALSE +"HCC44","Pearson.est","src inhibitor",0.31506,0.863,0.614,336,0.734,"ZM.306416, saracatinib, PP.1, TG.100572",0.211831628858832,0.134303940083929,FALSE +"HCC44","Pearson.est","sterol demethylase inhibitor",-0.62775,-1.56,0.0442,1342,0.299,"lanoconazole, chlormidazole",1.35457773065091,0.52432881167557,FALSE +"HCC44","Pearson.est","TGF beta receptor inhibitor",0.90858,2.48,0,119,0,"SB.431542, SB.525334, repsox, LY2109761, adaprev",Inf,Inf,TRUE +"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.49448,-1.21,0.258,1197,0.62,"ftorafur, trifluridine, raltitrexed",0.58838029403677,0.207608310501746,FALSE +"HCC44","Pearson.est","topoisomerase inhibitor",-0.79345,-1.95,0,1276,0.101,"irinotecan, doxorubicin, camptothecin, teniposide, nemorubicin, amonafide, topotecan, valrubicin, SN.38, etoposide, mitoxantrone, TAS.103, exatecan.mesylate, rubitecan, idarubicin, genz.644282, voreloxin, amsacrine",Inf,0.995678626217357,TRUE +"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.49754,-1.24,0.212,1186,0.582,"mebendazole, oxibendazole, paclitaxel, fosbretabulin, docetaxel, vinblastine, verubulin, fenbendazole, BNC105, epothilone.b",0.673664139071249,0.235077015350112,FALSE +"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.31221,-0.759,0.779,1044,0.968,"dasatinib, tyrphostin.AG.99, aminopurvalanol.a, UNC2250, bafetinib, NVP.TAE226, cabozantinib, AMG.208",0.108462542327436,0.0141246426916063,FALSE +"HCC44","Pearson.est","VEGFR inhibitor",0.31684,0.877,0.537,217,0.78,"orantinib, cediranib, AEE788, lenvatinib, ZM.306416, PD.173074, BMS.690514, semaxanib, telatinib, motesanib, vandetanib",0.270025714300444,0.10790539730952,FALSE +"HCC44","Pearson.est","vitamin D receptor agonist",0.41248,1.14,0.297,299,0.76,"paricalcitol, maxacalcitol, alfacalcidol, tacalcitol",0.527243550682788,0.119186407719209,FALSE +"H1299","Pearson.est","EGFR inhibitor",0.68763,1.72,0.026,223,0.534,"erlotinib, WZ8040, osimertinib, OSI.420, pelitinib, PD.168393, BIBU.1361, canertinib, icotinib, CP.724714, afatinib, BMS.690514, dacomitinib, gefitinib, rociletinib, vandetanib, XL.647, AZD8931, ARRY.334543, tyrphostin.AG.1478, BIBX.1382, AEE788, PD.153035, poziotinib, CNX.2006",1.58502665202918,0.272458742971444,FALSE +"H1299","Pearson.est","Abl kinase inhibitor",0.18657,0.46,0.993,524,0.991,"ZM.306416, imatinib, bosutinib, metatinib, KW.2449",0.00305075150461883,0.00392634551472468,FALSE +"H1299","Pearson.est","acetylcholine receptor agonist",-0.41687,-1.09,0.33,1333,0.73,"nicotine, xanomeline",0.481486060122112,0.136677139879544,FALSE +"H1299","Pearson.est","acetylcholine receptor antagonist",-0.26832,-0.697,0.824,1079,0.898,"iododexetimide, methscopolamine, hyoscyamine",0.0840727883028842,0.0467236633326956,FALSE +"H1299","Pearson.est","adenosine receptor antagonist",0.84642,2.09,0,166,0.0301,"CGS.15943, MRS.1220, SCH.58261, PSB.1115",Inf,1.52143350440616,TRUE +"H1299","Pearson.est","adrenergic receptor agonist",0.37973,0.957,0.484,215,0.815,"oxymetazoline, A61603, isoetharine",0.315154638355588,0.0888423912600234,FALSE +"H1299","Pearson.est","adrenergic receptor antagonist",0.23303,0.575,0.961,121,1,"atenolol...., RS.17053, dronedarone",0.0172766123314547,0,FALSE +"H1299","Pearson.est","AKT inhibitor",0.5506,1.37,0.141,461,0.535,"CCT128930, palomid.529, GSK2110183, AZD5363, A.674563, uprosertib",0.85078088734462,0.271646217978772,FALSE +"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.40573,1.01,0.434,385,0.8,"NVP.TAE684, GW.788388, SB.505124, AZD3463, alectinib, AP26113",0.362510270487489,0.0969100130080564,FALSE +"H1299","Pearson.est","androgen receptor antagonist",-0.32639,-0.856,0.605,1022,0.906,"nilutamide, RU.58841, enzalutamide",0.218244625347531,0.0428718023231869,FALSE +"H1299","Pearson.est","antioxidant",0.2349,0.576,0.931,350,1,"benfotiamine, taurine",0.0310503190186574,0,FALSE +"H1299","Pearson.est","AP inhibitor",0.38154,0.925,0.545,480,0.849,"embelin, birinapant, LCL.161, tanshinone.i",0.263603497723358,0.0710923097560473,FALSE +"H1299","Pearson.est","ATPase inhibitor",-0.76663,-1.99,0.0049,1312,0.189,"rabeprazole, digitoxigenin, evodiamine, thonzonium, digoxin, oligomycin.a, k.strophanthidin",2.30980391997149,0.723538195826756,TRUE +"H1299","Pearson.est","Aurora kinase inhibitor",-0.51823,-1.34,0.167,1078,0.831,"hesperadin, tozasertib, GSK1070916, barasertib, ENMD.2076, SNS.314, CCT137690, TAK.901, MK.5108, AT.9283, AMG900, aurora.a.inhibitor.i",0.777283528852417,0.080398976215889,FALSE +"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.40693,-1.07,0.332,1171,0.73,"valnemulin, josamycin",0.478861916295964,0.136677139879544,FALSE +"H1299","Pearson.est","bacterial DNA gyrase inhibitor",-0.4439,-1.19,0.215,1121,0.626,"nadifloxacin, norfloxacin, lomefloxacin",0.667561540084395,0.20342566678957,FALSE +"H1299","Pearson.est","BCL inhibitor",-0.35184,-0.906,0.558,940,0.919,"obatoclax, venetoclax, TW.37, ABT.737, gossypol",0.253365801062421,0.0366844886138887,FALSE +"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.28902,-0.761,0.749,1086,0.883,"tozasertib, ponatinib, GZD824",0.125518182300534,0.0540392964224314,FALSE +"H1299","Pearson.est","benzodiazepine receptor agonist",0.49785,1.23,0.243,348,0.528,"lorazepam, nefiracetam, gamma.aminobutyric.acid, CGS.20625, piperazine, zaleplon",0.614393726401688,0.277366077466188,FALSE +"H1299","Pearson.est","bromodomain inhibitor",0.53208,1.35,0.159,467,0.532,"JQ1...., I.BET151",0.798602875679548,0.274088367704952,FALSE +"H1299","Pearson.est","calcium channel blocker",0.24787,0.618,0.918,568,1,"cinnarazine, SR.33805, fendiline, pranidipine, mibefradil, efonidipine.monoethanolate",0.0371573187987575,0,FALSE +"H1299","Pearson.est","CC chemokine receptor antagonist",-0.48089,-1.28,0.18,1345,0.787,"ZK811752, SB.225002, UNBS.5162",0.744727494896694,0.104025267640935,FALSE +"H1299","Pearson.est","CDK inhibitor",0.22838,0.562,0.942,177,1,"arcyriaflavin.a, indirubin, BMS.387032",0.0259490972071227,0,FALSE +"H1299","Pearson.est","CHK inhibitor",0.27134,0.681,0.849,1057,1,"LY2603618, CHIR.124, AZD7762, SCH.900776, SB.218078, LY2606368, PF.477736",0.0710923097560473,0,FALSE +"H1299","Pearson.est","cyclooxygenase inhibitor",0.36488,0.909,0.531,430,0.85,"tryptanthrin, FR.122047, indoprofen, phenylbutazone, FK.3311, pterostilbene, suxibuzone, ramifenazone, AM.404, metoxibutropate, ketoprofen, meloxicam",0.274905478918531,0.0705810742857073,FALSE +"H1299","Pearson.est","cytochrome P450 inhibitor",0.51842,1.33,0.172,238,0.464,"morin, PF.4981517, itraconazole",0.764471553092451,0.333482019445119,FALSE +"H1299","Pearson.est","DNA alkylating agent",0.2981,0.733,0.777,226,1,"ifosfamide, streptozotocin, dacarbazine, TH.302",0.109578981199086,0,FALSE +"H1299","Pearson.est","DNA inhibitor",-0.48524,-1.25,0.228,1137,0.709,"valrubicin, tirapazamine, mechlorethamine, chlorambucil, carboplatin, carmustine, sangivamycin, metronidazole",0.642065152999546,0.149353764816933,FALSE +"H1299","Pearson.est","DNA methyltransferase inhibitor",0.53699,1.33,0.163,410,0.464,"azacitidine, RG108, SGI.1027, fdcyd",0.787812395596042,0.333482019445119,FALSE +"H1299","Pearson.est","DNA polymerase inhibitor",-0.51409,-1.34,0.155,1363,0.831,"trifluridine, foscarnet",0.809668301829709,0.080398976215889,FALSE +"H1299","Pearson.est","DNA synthesis inhibitor",0.20596,0.525,0.966,593,1,"estramustine.phosphate, capecitabine, floxuridine, altretamine, enocitabine, artemisinin, cisplatin",0.0150228735845067,0,FALSE +"H1299","Pearson.est","dopamine receptor antagonist",-0.22816,-0.584,0.938,1252,0.936,"clebopride, domperidone, thioproperazine",0.0277971616209356,0.0287241512618947,FALSE +"H1299","Pearson.est","estrogen receptor agonist",-0.39932,-1.02,0.408,1047,0.793,"ethinyl.estradiol, equol, estrone, levonorgestrel",0.38933983691012,0.100726812682396,FALSE +"H1299","Pearson.est","estrogen receptor antagonist",-0.3835,-1.01,0.433,1387,0.773,"toremifene",0.363512103646635,0.111820506081675,FALSE +"H1299","Pearson.est","FGFR inhibitor",0.39361,0.981,0.452,19,0.797,"PD.173074, orantinib",0.344861565188618,0.0985416786038876,FALSE +"H1299","Pearson.est","FLT3 inhibitor",-0.31966,-0.821,0.652,1086,0.939,"tozasertib, TG.101348, ponatinib, ENMD.2076, sorafenib, dovitinib, tyrphostin.AG.1296",0.18575240426808,0.0273344077338891,FALSE +"H1299","Pearson.est","glucocorticoid receptor agonist",0.40959,1.02,0.452,491,0.812,"betamethasone, rimexolone, flumethasone, fludroxycortide, clobetasol.propionate, triamcinolone.acetonide, prednisolone.hemisuccinate, prednisolone.acetate, flumethasone.pivalate, deflazacort, fluocinolone.acetonide, halcinonide, ciclesonide, methylprednisolone",0.344861565188618,0.0904439707588247,FALSE +"H1299","Pearson.est","glutamate receptor antagonist",0.4723,1.15,0.312,583,0.615,"latrepirdine, MTPG, SIB.1757, kynurenic.acid, CPP, LY456236, ACDPP, JNJ.16259685, diazooxonorleucine, felbamate",0.505845405981557,0.211124884224583,FALSE +"H1299","Pearson.est","glycogen synthase kinase inhibitor",0.56549,1.38,0.125,302,0.56,"LY2090314, indirubin, GSK.3.inhibitor.IX, CHIR.99021, kenpaullone",0.903089986991944,0.2518119729938,FALSE +"H1299","Pearson.est","growth factor receptor inhibitor",0.36105,0.893,0.585,436,0.826,"GSK1904529A, AZD3463, GSK1838705A, GW.441756",0.23284413391782,0.0830199526796178,FALSE +"H1299","Pearson.est","HCV inhibitor",0.53087,1.33,0.173,411,0.464,"Ro.9187, embelin, daclatasvir, PSI.7976",0.761953896871205,0.333482019445119,FALSE +"H1299","Pearson.est","HDAC inhibitor",0.63048,1.54,0.065,464,0.431,"nexturastat.a, JNJ.26481585, tacedinaline, romidepsin, R306465, SB.939, panobinostat, pyroxamide, RG2833, entinostat, PCI.24781, M.344, vorinostat, resminostat, RGFP966, chidamide",1.18708664335714,0.365522729839268,FALSE +"H1299","Pearson.est","histamine receptor antagonist",0.56096,1.39,0.127,454,0.592,"terfenadine, levocetirizine, tecastemizole, astemizole, zolantidine, epinastine, cyproheptadine, ICI.162846, ebastine, ranitidine, tiotidine, BF2.649, pheniramine",0.896196279044043,0.22767829327708,FALSE +"H1299","Pearson.est","HMGCR inhibitor",-0.49338,-1.29,0.207,1060,0.858,"fluvastatin, atorvastatin, lovastatin",0.684029654543082,0.0665127121512946,FALSE +"H1299","Pearson.est","HSP inhibitor",0.3278,0.802,0.674,383,0.911,"alvespimycin, tanespimycin, SNX.5422, VER.49009, XL888",0.17134010346468,0.0404816230270017,FALSE +"H1299","Pearson.est","JAK inhibitor",0.19503,0.497,0.977,412,1,"pacritinib, LY2784544, atiprimod, TG.02, PRT062070",0.0101054362812269,0,FALSE +"H1299","Pearson.est","KIT inhibitor",-0.31933,-0.819,0.653,1228,0.908,"regorafenib, pazopanib, sorafenib, lenvatinib",0.185086818724926,0.0419141514789149,FALSE +"H1299","Pearson.est","MDM inhibitor",0.67602,1.68,0.0385,333,0.462,"CGM097, RITA, serdemetan, nutlin.3",1.4145392704915,0.335358024443874,FALSE +"H1299","Pearson.est","MEK inhibitor",0.34066,0.851,0.623,153,0.85,"nobiletin, BIX.02188, arctigenin",0.20551195334083,0.0705810742857073,FALSE +"H1299","Pearson.est","MET inhibitor",-0.60713,-1.62,0.0573,1430,0.506,"LY2801653",1.24184537803261,0.295849483160201,FALSE +"H1299","Pearson.est","microtubule inhibitor",-0.37948,-0.998,0.443,1089,0.761,"cabazitaxel, D.64131, vinflunine, vinblastine, secnidazole",0.35359627377693,0.118615343229427,FALSE +"H1299","Pearson.est","mTOR inhibitor",-0.28756,-0.73,0.797,1143,0.878,"torin.1, voxtalisib, MLN0128, AZD2014, OSI.027, PKI.179, SB.2343, ku.0063794, PF.04691502",0.0985416786038876,0.0565054840938974,FALSE +"H1299","Pearson.est","NFkB pathway inhibitor",-0.26027,-0.685,0.821,1427,0.887,"EVP4593",0.0856568428805592,0.0520763801682736,FALSE +"H1299","Pearson.est","opioid receptor agonist",-0.31462,-0.805,0.679,1382,0.899,"trimebutine",0.168130225719498,0.0462403082667712,FALSE +"H1299","Pearson.est","p38 MAPK inhibitor",0.43498,1.07,0.362,465,0.741,"SB.239063, SB.242235, VX.702, skepinone.l",0.441291429466834,0.130181792020672,FALSE +"H1299","Pearson.est","PARP inhibitor",0.58629,1.46,0.111,570,0.547,"endo.IWR.1, PJ.34, AG.14361, E7449, AZD2461, niraparib, talazoparib",0.954677021213343,0.262012673666569,FALSE +"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30355,-0.789,0.707,1228,0.867,"regorafenib, pazopanib, sorafenib, lenvatinib, linifanib, dovitinib, nintedanib",0.150580586203101,0.0619809025237897,FALSE +"H1299","Pearson.est","phosphatase inhibitor",-0.33363,-0.865,0.632,1225,0.926,"GSK2830371, bis.maltolato.oxovanadium.IV., alexidine",0.199282921717615,0.0333890133180656,FALSE +"H1299","Pearson.est","phosphodiesterase inhibitor",0.66011,1.64,0.0452,340,0.357,"GSK256066, papaverine, cilostamide, zardaverine, YM.976, anagrelide, trequinsin",1.34486156518862,0.447331783887807,FALSE +"H1299","Pearson.est","PI3K inhibitor",-0.30552,-0.79,0.709,1290,0.895,"PKI.179, SB.2343, PF.04691502, buparlisib, GDC.0941",0.149353764816933,0.048176964684088,FALSE +"H1299","Pearson.est","PLK inhibitor",-0.69674,-1.83,0.0147,1004,0.304,"GSK461364, BI.2536, HMN.214, rigosertib, NMS.1286937, volasertib, GW.843682X",1.83268266525182,0.517126416391246,FALSE +"H1299","Pearson.est","potassium channel blocker",0.52291,1.31,0.18,99,0.422,"oleoylethanolamide",0.744727494896694,0.374687549038326,FALSE +"H1299","Pearson.est","PPAR receptor agonist",0.51912,1.31,0.174,291,0.422,"S26948, oleoylethanolamide, ciprofibrate, pterostilbene",0.7594507517174,0.374687549038326,FALSE +"H1299","Pearson.est","progesterone receptor agonist",-0.46786,-1.19,0.231,1262,0.626,"norethindrone, levonorgestrel, tanaproget, nomegestrol.acetate",0.636388020107856,0.20342566678957,FALSE +"H1299","Pearson.est","proteasome inhibitor",-0.22566,-0.587,0.926,1210,0.96,"delanzomib, MG.132",0.0333890133180656,0.0177287669604316,FALSE +"H1299","Pearson.est","protein synthesis inhibitor",-0.41597,-1.1,0.329,1216,0.754,"bruceantin, mercaptopurine, anguidine, harringtonine, cycloheximide, chloramphenicol.palmitate, clofoctol",0.482804102050026,0.122628654130226,FALSE +"H1299","Pearson.est","protein tyrosine kinase inhibitor",0.35673,0.906,0.545,181,0.828,"CP.724714, NVP.TAE226",0.263603497723358,0.0819696632151199,FALSE +"H1299","Pearson.est","RAF inhibitor",0.35669,0.892,0.591,301,0.803,"GDC.0879, CEP.32496, LGX818, dabrafenib",0.228412519118745,0.095284454721319,FALSE +"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.34836,-0.887,0.558,1211,0.919,"cabozantinib, regorafenib, sorafenib",0.253365801062421,0.0366844886138887,FALSE +"H1299","Pearson.est","retinoid receptor agonist",-0.48439,-1.26,0.204,1425,0.755,"adapalene, fenretinide",0.690369832574101,0.122053048370812,FALSE +"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.44675,-1.2,0.236,1003,0.7,"fludarabine.phosphate, cladribine, triapine, hydroxyurea, pentostatin",0.627087997029893,0.154901959985743,FALSE +"H1299","Pearson.est","serotonin receptor agonist",0.66616,1.65,0.0298,26,0.417,"ipsapirone, aripiprazole",1.52578373592374,0.379863945026242,FALSE +"H1299","Pearson.est","serotonin receptor antagonist",0.52829,1.32,0.154,96,0.454,"aripiprazole, SB.228357, ziprasidone",0.812479279163537,0.342944147142896,FALSE +"H1299","Pearson.est","sodium channel blocker",-0.29217,-0.759,0.74,1305,0.859,"oxcarbazepine, cibenzoline, benzocaine",0.130768280269024,0.0660068361687577,FALSE +"H1299","Pearson.est","src inhibitor",0.63064,1.55,0.0568,222,0.479,"saracatinib, PP.2, ZM.306416, PP.1",1.24565166428898,0.319664486585437,FALSE +"H1299","Pearson.est","sterol demethylase inhibitor",-0.67554,-1.71,0.0201,1231,0.437,"lanoconazole, posaconazole, sulconazole, chlormidazole",1.69680394257951,0.359518563029578,FALSE +"H1299","Pearson.est","TGF beta receptor inhibitor",0.57581,1.42,0.122,216,0.577,"LY2109761, D.4476, repsox",0.913640169325252,0.238824186844269,FALSE +"H1299","Pearson.est","thymidylate synthase inhibitor",0.39961,0.991,0.451,330,0.807,"doxifluridine, capecitabine, carmofur, raltitrexed",0.345823458122039,0.0931264652779296,FALSE +"H1299","Pearson.est","topoisomerase inhibitor",-0.54145,-1.41,0.135,1265,0.922,"amsacrine, idarubicin, TAS.103, voreloxin, topotecan, SN.38, epirubicin, dexrazoxane, etoposide.phosphate, doxorubicin, mitoxantrone",0.869666231504994,0.0352690789463706,FALSE +"H1299","Pearson.est","tubulin polymerization inhibitor",-0.46268,-1.22,0.233,1154,0.714,"epothilone.b, verubulin, mebendazole, docetaxel, oxibendazole, vinblastine, BNC105, paclitaxel, vindesine, fenbendazole",0.632644078973981,0.146301788223826,FALSE +"H1299","Pearson.est","tyrosine kinase inhibitor",0.23223,0.594,0.921,261,1,"CP.724714, vandetanib, NVP.TAE226, apatinib",0.0357403698031511,0,FALSE +"H1299","Pearson.est","VEGFR inhibitor",0.29058,0.728,0.811,204,0.98,"PD.173074, orantinib, BMS.690514, vandetanib, XL.647, ZM.306416, AEE788, vatalanib",0.090979145788844,0.00877392430750515,FALSE +"H1299","Pearson.est","vitamin D receptor agonist",0.48464,1.19,0.264,423,0.572,"maxacalcitol, ercalcitriol, tacalcitol, calcitriol",0.578396073130169,0.242603971206976,FALSE +"H1703","Pearson.est","EGFR inhibitor",0.38864,0.955,0.503,353,0.884,"WZ8040, erlotinib, BIBU.1361, icotinib, TAK.285, pelitinib, tyrphostin.AG.1478, osimertinib, BMS.599626, OSI.420, canertinib, afatinib, PD.168393, vandetanib, gefitinib, rociletinib, lapatinib, PD.153035, BIBX.1382",0.298432014944073,0.0535477349869269,FALSE +"H1703","Pearson.est","Abl kinase inhibitor",0.35697,0.9,0.58,568,0.884,"imatinib, bafetinib, tozasertib, metatinib, KW.2449, bosutinib",0.236572006437063,0.0535477349869269,FALSE +"H1703","Pearson.est","acetylcholine receptor agonist",-0.53837,-1.37,0.157,1222,0.61,"nicotine, xanomeline",0.804100347590766,0.214670164989233,FALSE +"H1703","Pearson.est","acetylcholine receptor antagonist",-0.30375,-0.805,0.68,1393,1,"methscopolamine",0.167491087293764,0,FALSE +"H1703","Pearson.est","adenosine receptor antagonist",0.55072,1.39,0.112,502,0.397,"CGS.15943, sulmazole, SCH.58261, MRS.1220",0.950781977329818,0.401209493236885,FALSE +"H1703","Pearson.est","adrenergic receptor agonist",0.30805,0.768,0.753,552,1,"oxymetazoline, epinephrine, isoxsuprine, clenbuterol, terbutaline, methyldopa, A61603, norepinephrine",0.123205023799299,0,FALSE +"H1703","Pearson.est","adrenergic receptor antagonist",0.25876,0.647,0.875,179,0.992,"levobunolol, dronedarone, RS.17053, vincamine",0.0579919469776868,0.00348832784582135,FALSE +"H1703","Pearson.est","AKT inhibitor",0.64625,1.59,0.0469,107,0.52,"palomid.529, triciribine, uprosertib, CCT128930",1.32882715728492,0.283996656365201,FALSE +"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.30936,0.76,0.77,529,0.994,"NVP.TAE684, GW.788388, CEP.37440, AZD3463",0.113509274827518,0.00261361560268669,FALSE +"H1703","Pearson.est","androgen receptor antagonist",0.23735,0.585,0.931,355,0.952,"bicalutamide, cyproterone.acetate",0.0310503190186574,0.0213630516155257,FALSE +"H1703","Pearson.est","antioxidant",-0.63063,-1.65,0.0446,1421,0.481,"trolox",1.35066514128786,0.317854923626168,FALSE +"H1703","Pearson.est","AP inhibitor",0.54543,1.35,0.146,189,0.44,"embelin, LCL.161, GDC.0152",0.835647144215563,0.356547323513813,FALSE +"H1703","Pearson.est","ATPase inhibitor",-0.72755,-1.88,0.00959,1087,0.381,"omeprazole, digitoxin, digitoxigenin, blebbistatin...., NMS.873, evodiamine, digoxin, oligomycin.a, k.strophanthidin",2.01818139282934,0.419075024324381,FALSE +"H1703","Pearson.est","Aurora kinase inhibitor",-0.3022,-0.785,0.716,977,0.923,"alisertib, AMG900, barasertib, danusertib, CCT137690, SNS.314, CYC116, CCT129202, TAK.901, PHA.680632, aurora.a.inhibitor.i, AT.9283",0.145086977692144,0.0347982989740879,FALSE +"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.4503,-1.15,0.281,1424,0.857,"josamycin",0.55129368009492,0.0670191780768018,FALSE +"H1703","Pearson.est","bacterial DNA gyrase inhibitor",-0.35986,-0.926,0.518,1158,1,"norfloxacin, lomefloxacin, nadifloxacin",0.285670240254767,0,FALSE +"H1703","Pearson.est","BCL inhibitor",-0.44314,-1.14,0.298,1118,0.733,"obatoclax, ABT.737, TW.37, gossypol",0.525783735923745,0.134896025358872,FALSE +"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.48373,1.2,0.254,398,0.558,"imatinib, bafetinib, tozasertib, metatinib",0.595166283380062,0.253365801062421,FALSE +"H1703","Pearson.est","benzodiazepine receptor agonist",0.24082,0.596,0.913,650,0.963,"zaleplon, piperazine, ivermectin, CGS.20625, lorazepam, eprinomectin, nefiracetam, indiplon",0.039529222465701,0.0163737128754655,FALSE +"H1703","Pearson.est","bromodomain inhibitor",0.25937,0.644,0.883,651,0.975,"JQ1...., I.BET.762, bromosporine, OTX015",0.0540392964224314,0.0109953843014632,FALSE +"H1703","Pearson.est","calcium channel blocker",-0.41244,-1.05,0.383,1191,0.876,"mibefradil, efonidipine.monoethanolate, carboxyamidotriazole",0.416801226031377,0.0574958938319193,FALSE +"H1703","Pearson.est","CC chemokine receptor antagonist",0.37659,0.935,0.544,211,0.87,"navarixin, RS.504393",0.26440110030182,0.0604807473813815,FALSE +"H1703","Pearson.est","CDK inhibitor",0.2913,0.729,0.799,386,0.972,"alvocidib, AZD5438, arcyriaflavin.a, kenpaullone, BMS.387032, PHA.793887, TG.02",0.0974532206860086,0.0123337350737254,FALSE +"H1703","Pearson.est","CHK inhibitor",0.56965,1.44,0.116,240,0.393,"LY2603618, SCH.900776, LY2606368",0.935542010773082,0.405607449624573,FALSE +"H1703","Pearson.est","cyclooxygenase inhibitor",0.44743,1.14,0.306,320,0.62,"indoprofen, amfenac, FK.3311, tryptanthrin, metoxibutropate, curcumin, meloxicam, FR.122047, acetylsalicylsalicylic.acid, ramifenazone, AM.404",0.51427857351842,0.207608310501746,FALSE +"H1703","Pearson.est","cytochrome P450 inhibitor",0.41795,1.03,0.395,48,0.805,"itraconazole",0.40340290437354,0.0942041196321315,FALSE +"H1703","Pearson.est","DNA alkylating agent",0.47643,1.17,0.259,475,0.589,"dacarbazine, TH.302, dianhydrogalactitol, streptozotocin, ifosfamide, estramustine, cisplatin, melphalan",0.586700235918748,0.229884705212898,FALSE +"H1703","Pearson.est","DNA inhibitor",0.34829,0.857,0.611,17,0.919,"busulfan, nithiamide",0.213958789757446,0.0366844886138887,FALSE +"H1703","Pearson.est","DNA methyltransferase inhibitor",0.51707,1.29,0.19,368,0.493,"azacitidine, fdcyd, decitabine, SGI.1027",0.721246399047171,0.30715308072277,FALSE +"H1703","Pearson.est","DNA polymerase inhibitor",-0.30347,-0.789,0.689,437,0.957,"famciclovir, cephalomannine, cidofovir, idoxuridine, trifluridine, adefovir.dipivoxil, foscarnet, menadione",0.161780778092374,0.0190880622231565,FALSE +"H1703","Pearson.est","DNA synthesis inhibitor",0.33706,0.834,0.657,442,0.938,"altretamine, floxuridine, anisomycin, estramustine.phosphate, capecitabine, enocitabine, cisplatin",0.182434630440219,0.0277971616209356,FALSE +"H1703","Pearson.est","dopamine receptor antagonist",0.24535,0.608,0.918,435,0.971,"isofloxythepin, ziprasidone, acetophenazine, mesoridazine, oxiperomide, amisulpride, paliperidone",0.0371573187987575,0.0127807700919951,FALSE +"H1703","Pearson.est","estrogen receptor agonist",-0.33787,-0.88,0.601,1196,1,"estrone, levonorgestrel, erteberel",0.22112552799726,0,FALSE +"H1703","Pearson.est","estrogen receptor antagonist",0.30386,0.751,0.767,591,0.984,"raloxifene, toremifene, fulvestrant",0.115204636051019,0.00700490156865849,FALSE +"H1703","Pearson.est","FGFR inhibitor",-0.30946,-0.799,0.68,1376,0.984,"nintedanib, erdafitinib",0.167491087293764,0.00700490156865849,FALSE +"H1703","Pearson.est","FLT3 inhibitor",0.38237,0.951,0.496,92,0.864,"tandutinib, sunitinib, pacritinib",0.304518323509803,0.0634862575211067,FALSE +"H1703","Pearson.est","glucocorticoid receptor agonist",-0.54845,-1.46,0.114,1102,0.617,"prednisolone.hemisuccinate, methylprednisolone, betamethasone, deflazacort, flumethasone.pivalate, fluocinolone.acetonide, triamcinolone, fluticasone.propionate, clobetasol.propionate, halcinonide, triamcinolone.acetonide, desonide, dexamethasone.acetate, beclomethasone.dipropionate, hydrocortisone",0.943095148663527,0.209714835966758,FALSE +"H1703","Pearson.est","glutamate receptor antagonist",0.58621,1.46,0.104,111,0.388,"diazooxonorleucine, SIB.1757, latrepirdine, MTPG",0.98296666070122,0.411168274405793,FALSE +"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.52064,1.28,0.202,289,0.487,"AZD2858, GSK.3.inhibitor.IX, LY2090314, kenpaullone",0.694648630553376,0.312471038785366,FALSE +"H1703","Pearson.est","growth factor receptor inhibitor",-0.24705,-0.657,0.882,356,1,"GW.441756, GSK1838705A, lestaurtinib, AZD3463, GSK1904529A, danusertib, PHA.848125",0.0545314148681803,0,FALSE +"H1703","Pearson.est","HCV inhibitor",0.75696,1.93,0.00348,187,0.183,"embelin, PSI.7976, Ro.9187, daclatasvir",2.45842075605342,0.737548910269571,TRUE +"H1703","Pearson.est","HDAC inhibitor",0.60355,1.48,0.0889,307,0.417,"JNJ.26481585, tacedinaline, SB.939, M.344, vorinostat, panobinostat, R306465, romidepsin, RG2833, PCI.24781, nexturastat.a, ACY.1215, dacinostat",1.05109823902979,0.379863945026242,FALSE +"H1703","Pearson.est","histamine receptor antagonist",0.59234,1.52,0.0892,310,0.538,"chloropyramine, levocetirizine, terfenadine, zolantidine, tecastemizole, tiotidine, ICI.162846, ranitidine, cimetidine",1.04963514562388,0.269217724333611,FALSE +"H1703","Pearson.est","HMGCR inhibitor",-0.31216,-0.816,0.647,1201,1,"lovastatin, atorvastatin",0.1890957193313,0,FALSE +"H1703","Pearson.est","HSP inhibitor",0.60819,1.54,0.0607,360,0.571,"VER.49009, XL888, alvespimycin, guanidine, tanespimycin, SNX.5422, SNX.2112, PU.H71, BIIB021, NVP.AUY922",1.21681130892474,0.243363891754152,FALSE +"H1703","Pearson.est","JAK inhibitor",0.26534,0.657,0.859,161,1,"atiprimod, pacritinib, LY2784544",0.0660068361687577,0,FALSE +"H1703","Pearson.est","KIT inhibitor",0.59317,1.49,0.0859,459,0.484,"tandutinib, imatinib, sunitinib, telatinib, regorafenib, KI.8751, vatalanib, motesanib, OSI.930",1.06600683616876,0.315154638355588,FALSE +"H1703","Pearson.est","MDM inhibitor",-0.24682,-0.637,0.882,1305,1,"AMG.232",0.0545314148681803,0,FALSE +"H1703","Pearson.est","MEK inhibitor",0.30054,0.739,0.775,160,0.98,"BIX.02188, nobiletin, arctigenin",0.11069829749369,0.00877392430750515,FALSE +"H1703","Pearson.est","MET inhibitor",0.57091,1.42,0.103,226,0.398,"AMG458, INC.280",0.987162775294828,0.400116927926312,FALSE +"H1703","Pearson.est","microtubule inhibitor",-0.23305,-0.607,0.916,1077,1,"triclabendazole, vinblastine, secnidazole, cytochalasin.b",0.0381045263321496,0,FALSE +"H1703","Pearson.est","mTOR inhibitor",-0.20278,-0.527,0.977,1170,1,"voxtalisib, WYE.354, WYE.125132, XL388, OSI.027, torin.1, PF.04691502, SB.2343",0.0101054362812269,0,FALSE +"H1703","Pearson.est","NFkB pathway inhibitor",-0.44003,-1.14,0.306,1428,0.733,"tyloxapol, EVP4593",0.51427857351842,0.134896025358872,FALSE +"H1703","Pearson.est","opioid receptor agonist",0.32424,0.806,0.714,42,0.964,"salvinorin.a",0.146301788223826,0.0159229660971692,FALSE +"H1703","Pearson.est","p38 MAPK inhibitor",0.49636,1.22,0.246,615,0.547,"CMPD.1, TAK.715, skepinone.l, VX.702, SB.242235, SB.239063",0.609064892896621,0.262012673666569,FALSE +"H1703","Pearson.est","PARP inhibitor",0.58946,1.46,0.106,507,0.388,"PJ.34, niraparib, olaparib, talazoparib, endo.IWR.1, E7449",0.97469413473523,0.411168274405793,FALSE +"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.50652,1.26,0.196,415,0.498,"tandutinib, trapidil, imatinib, sunitinib, telatinib, orantinib, regorafenib, KI.8751, vatalanib, motesanib",0.707743928643524,0.302770657240282,FALSE +"H1703","Pearson.est","phosphatase inhibitor",-0.34728,-0.882,0.583,1298,1,"menadione, bis.maltolato.oxovanadium.IV., GSK2830371",0.234331445240986,0,FALSE +"H1703","Pearson.est","phosphodiesterase inhibitor",0.28274,0.711,0.805,491,0.976,"papaverine, YM.976, GSK256066, EMD.53998, trequinsin, cilostamide",0.0942041196321315,0.0105501823333082,FALSE +"H1703","Pearson.est","PI3K inhibitor",-0.20933,-0.556,0.959,1122,1,"AZD6482, GDC.0941, voxtalisib, PI.828, ZSTK.474, buparlisib, PF.04691502, SB.2343",0.0181813928293364,0,FALSE +"H1703","Pearson.est","PLK inhibitor",-0.64979,-1.66,0.0354,1174,0.69,"GW.843682X, volasertib, NMS.1286937",1.45099673797421,0.161150909262745,FALSE +"H1703","Pearson.est","potassium channel blocker",0.67074,1.68,0.026,199,0.376,"oleoylethanolamide, meglitinide",1.58502665202918,0.424812155072339,FALSE +"H1703","Pearson.est","PPAR receptor agonist",-0.3356,-0.875,0.588,1251,0.978,"fenofibrate, clofibrate",0.230622673923862,0.00966114521239857,FALSE +"H1703","Pearson.est","progesterone receptor agonist",-0.65251,-1.64,0.0404,1168,0.375,"nomegestrol.acetate, levonorgestrel, tanaproget, norethindrone",1.3936186348894,0.425968732272281,FALSE +"H1703","Pearson.est","proteasome inhibitor",0.69926,1.75,0.0189,343,0.303,"ixazomib.citrate, bortezomib, ixazomib, carfilzomib, ONX.0914, delanzomib",1.72353819582676,0.518557371497695,FALSE +"H1703","Pearson.est","protein synthesis inhibitor",-0.18251,-0.459,0.991,1025,0.992,"methacycline, bruceantin, cycloheximide, anguidine, clindamycin.phosphate, florfenicol, clofoctol, harringtonine",0.00392634551472468,0.00348832784582135,FALSE +"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.48176,-1.27,0.176,1400,0.74,"PP.121, mubritinib",0.75448733218585,0.130768280269024,FALSE +"H1703","Pearson.est","RAF inhibitor",0.60322,1.48,0.0938,157,0.417,"CEP.32496, dabrafenib, vemurafenib, AZ.628, GDC.0879",1.02779716162094,0.379863945026242,FALSE +"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.71558,1.81,0.0155,297,0.278,"apatinib, sunitinib, vandetanib, regorafenib",1.80966830182971,0.555955204081924,FALSE +"H1703","Pearson.est","retinoid receptor agonist",-0.45289,-1.21,0.225,1340,0.789,"adapalene, adarotene, fenretinide",0.647817481888638,0.10292299679058,FALSE +"H1703","Pearson.est","ribonucleotide reductase inhibitor",0.22045,0.547,0.961,454,0.959,"clofarabine, fludarabine.phosphate, gemcitabine, fludarabine, cladribine",0.0172766123314547,0.0181813928293364,FALSE +"H1703","Pearson.est","serotonin receptor agonist",-0.5439,-1.38,0.156,1256,0.685,"aripiprazole, zolmitriptan, NAN.190",0.806875401645538,0.164309428507574,FALSE +"H1703","Pearson.est","serotonin receptor antagonist",0.36039,0.911,0.539,170,0.89,"SB.228357, RS.16566, ziprasidone",0.268411234813261,0.0506099933550872,FALSE +"H1703","Pearson.est","sodium channel blocker",-0.30377,-0.78,0.697,1208,0.892,"oxcarbazepine, benzethonium, cibenzoline",0.156767221901991,0.0496351456238769,FALSE +"H1703","Pearson.est","src inhibitor",0.41338,1.02,0.412,296,0.798,"saracatinib, KX2.391, PP.2",0.385102783966865,0.0979971086492706,FALSE +"H1703","Pearson.est","sterol demethylase inhibitor",-0.37418,-0.983,0.445,1188,0.968,"chlormidazole, sulconazole, posaconazole",0.351639989019068,0.0141246426916063,FALSE +"H1703","Pearson.est","TGF beta receptor inhibitor",0.56756,1.4,0.122,182,0.405,"LY2109761, D.4476, repsox",0.913640169325252,0.392544976785331,FALSE +"H1703","Pearson.est","thymidylate synthase inhibitor",0.60845,1.5,0.0646,163,0.518,"doxifluridine, carmofur, raltitrexed",1.18976748200492,0.285670240254767,FALSE +"H1703","Pearson.est","topoisomerase inhibitor",0.35768,0.894,0.597,29,0.871,"licochalcone.a, exatecan.mesylate, genz.644282",0.224025668870631,0.0599818449923368,FALSE +"H1703","Pearson.est","tubulin polymerization inhibitor",0.256,0.637,0.894,347,0.962,"combretastatin.A.4, fosbretabulin, KX2.391, taltobulin, podophyllotoxin, mebendazole",0.0486624812040823,0.0168249279621871,FALSE +"H1703","Pearson.est","tyrosine kinase inhibitor",0.26618,0.68,0.838,431,0.995,"apatinib, sunitinib, BMS.599626, tivantinib, vandetanib, rheochrysidin, regorafenib, bafetinib, AV.412, CP.724714",0.0767559813697235,0.00217691925427455,FALSE +"H1703","Pearson.est","VEGFR inhibitor",0.38717,0.957,0.503,415,0.91,"MGCD.265, sunitinib, golvatinib, lucitanib, tivozanib, telatinib, orantinib, vandetanib, regorafenib, PD.173074, KI.8751, foretinib, vatalanib, motesanib",0.298432014944073,0.0409586076789064,FALSE +"H1703","Pearson.est","vitamin D receptor agonist",0.52833,1.31,0.176,290,0.485,"ercalcitriol, maxacalcitol, calcitriol, tacalcitol",0.75448733218585,0.314258261397736,FALSE +"H460","Pearson.est","EGFR inhibitor",0.45216,1.23,0.235,338,0.652,"AZD8931, dacomitinib, poziotinib, CGP.52411, CNX.2006, canertinib, tucatinib, AST.1306, afatinib, CP.724714, pelitinib, BMS.690514, salvianolic.acid.B, GW.583340, WZ.3146, WZ8040, ARRY.334543, rociletinib",0.628932137728264,0.18575240426808,FALSE +"H460","Pearson.est","Abl kinase inhibitor",-0.35853,-0.907,0.564,1296,0.792,"GZD824, bafetinib, KW.2449",0.248720896016658,0.101274818410506,FALSE +"H460","Pearson.est","acetylcholine receptor agonist",-0.31971,-0.796,0.718,1309,0.844,"tremorine",0.1438755557577,0.073657553374345,FALSE +"H460","Pearson.est","acetylcholine receptor antagonist",0.61147,1.66,0.0599,353,0.586,"methscopolamine, iododexetimide, dicycloverine, hyoscyamine",1.22257317761069,0.232102383981909,FALSE +"H460","Pearson.est","adenosine receptor antagonist",0.51036,1.42,0.122,433,0.607,"istradefylline, CGS.15943, theophylline, MRS.1220",0.913640169325252,0.216811308924742,FALSE +"H460","Pearson.est","adrenergic receptor agonist",0.34769,0.932,0.517,289,0.803,"ritodrine, xylazine, isoetharine, A61603, lidamidine, methyldopa",0.286509456906058,0.095284454721319,FALSE +"H460","Pearson.est","adrenergic receptor antagonist",0.34201,0.902,0.52,161,0.827,"RS.17053, atenolol...., atenolol......, prazosin, atipamezole",0.283996656365201,0.0824944904474534,FALSE +"H460","Pearson.est","AKT inhibitor",0.2885,0.773,0.715,273,0.868,"AT7867, GSK2110183, A.674563, MK.2206",0.145693958198919,0.0614802748235081,FALSE +"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.48337,-1.21,0.25,918,0.693,"GW.788388, brigatinib, CEP.37440, lorlatinib, AZD3463, crizotinib, alectinib",0.602059991327962,0.159266765388193,FALSE +"H460","Pearson.est","androgen receptor antagonist",0.2871,0.772,0.71,1034,0.841,"flutamide, cyproterone.acetate, RU.58841, nilutamide, enzalutamide, bicalutamide",0.148741651280925,0.0752040042020878,FALSE +"H460","Pearson.est","antioxidant",-0.58298,-1.48,0.0938,1281,0.504,"mesna, chlorogenic.acid",1.02779716162094,0.297569463554475,FALSE +"H460","Pearson.est","AP inhibitor",0.34813,0.934,0.505,946,0.924,"embelin, tanshinone.i, idronoxil, LCL.161, GDC.0152, birinapant",0.296708621881339,0.0343280287798933,FALSE +"H460","Pearson.est","ATPase inhibitor",0.4938,1.31,0.185,243,0.612,"k.strophanthidin, omeprazole, evodiamine, oligomycin.a, blebbistatin....",0.732828271596986,0.213248577854439,FALSE +"H460","Pearson.est","Aurora kinase inhibitor",-0.5177,-1.3,0.164,1078,0.788,"tozasertib, AMG900, danusertib, CCT137690, GSK1070916, MK.8745, MLN.8054, MK.5108, KW.2449, hesperadin, PF.03814735",0.785156151952302,0.103473782510445,FALSE +"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34419,-0.864,0.642,1351,0.777,"azalomycin.b, azithromycin",0.192464971931147,0.109578981199086,FALSE +"H460","Pearson.est","bacterial DNA gyrase inhibitor",-0.43582,-1.12,0.323,1362,0.708,"finafloxacin, novobiocin",0.490797477668897,0.149966742310231,FALSE +"H460","Pearson.est","BCL inhibitor",0.34983,0.94,0.508,99,0.963,"ABT.737, obatoclax",0.294136287716081,0.0163737128754655,FALSE +"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.36758,-0.928,0.536,1296,0.83,"GZD824, bafetinib",0.27083521030723,0.0809219076239261,FALSE +"H460","Pearson.est","benzodiazepine receptor agonist",0.28456,0.757,0.725,244,0.837,"temazepam, indiplon, CL.218872",0.139661993429006,0.07727454200674,FALSE +"H460","Pearson.est","bromodomain inhibitor",0.52422,1.42,0.109,348,0.607,"I.BET151, I.BET.762, bromosporine",0.962573502059376,0.216811308924742,FALSE +"H460","Pearson.est","calcium channel blocker",0.43034,1.15,0.299,240,0.703,"mibefradil, efonidipine.monoethanolate, tetrandrine, SKF.96365",0.52432881167557,0.153044674980176,FALSE +"H460","Pearson.est","CC chemokine receptor antagonist",-0.47775,-1.23,0.212,1045,0.731,"ZK811752, RS.504393, UNBS.5162, navarixin",0.673664139071249,0.13608262304214,FALSE +"H460","Pearson.est","CDK inhibitor",-0.36064,-0.915,0.544,998,0.827,"PHA.793887, JNJ.7706621, palbociclib, ribociclib, BMS.265246, abemaciclib, kenpaullone, PHA.848125, alvocidib, NU6027, AZD5438",0.26440110030182,0.0824944904474534,FALSE +"H460","Pearson.est","CHK inhibitor",-0.4908,-1.23,0.23,1176,0.731,"SCH.900776, LY2603618, LY2606368",0.638272163982407,0.13608262304214,FALSE +"H460","Pearson.est","cyclooxygenase inhibitor",-0.37715,-0.972,0.485,1072,0.802,"meloxicam, amfenac, phenazone, aspirin, curcumin, FR.122047, ramifenazone, indoprofen, suxibuzone, acetylsalicylsalicylic.acid",0.314258261397736,0.0958256317158365,FALSE +"H460","Pearson.est","cytochrome P450 inhibitor",0.40179,1.08,0.354,285,0.8,"metyrapone, itraconazole, morin",0.450996737974212,0.0969100130080564,FALSE +"H460","Pearson.est","DNA alkylating agent",-0.38599,-0.968,0.481,972,0.782,"satraplatin, dacarbazine, dianhydrogalactitol, melphalan, mitomycin.c, carboplatin, TH.302",0.317854923626168,0.106793246940152,FALSE +"H460","Pearson.est","DNA inhibitor",-0.53292,-1.35,0.145,1034,0.717,"tirapazamine, nithiamide, melphalan, sangivamycin, carboplatin, valrubicin, teroxirone",0.838631997765025,0.1444808443322,FALSE +"H460","Pearson.est","DNA methyltransferase inhibitor",-0.48792,-1.25,0.231,1039,0.792,"disulfiram, fdcyd, azacitidine, decitabine",0.636388020107856,0.101274818410506,FALSE +"H460","Pearson.est","DNA polymerase inhibitor",0.63593,1.71,0.041,129,0.702,"cidofovir, menadione, adefovir.dipivoxil, famciclovir",1.38721614328026,0.153662887870195,FALSE +"H460","Pearson.est","DNA synthesis inhibitor",-0.47728,-1.2,0.246,1101,0.677,"CB.10.277, anisomycin, mitomycin.c, altretamine, cyclocytidine, floxuridine",0.609064892896621,0.169411331314856,FALSE +"H460","Pearson.est","dopamine receptor antagonist",0.31068,0.832,0.622,297,0.798,"nemonapride, remoxipride, lurasidone, mesoridazine, clebopride, raclopride",0.206209615309181,0.0979971086492706,FALSE +"H460","Pearson.est","estrogen receptor agonist",0.27222,0.756,0.725,1056,0.812,"erteberel, ethinyl.estradiol, equol, PPT, estrone, estradiol.cypionate, levonorgestrel, estradiol",0.139661993429006,0.0904439707588247,FALSE +"H460","Pearson.est","estrogen receptor antagonist",0.58263,1.59,0.0576,5,0.582,"tamoxifen",1.23957751657679,0.235077015350112,FALSE +"H460","Pearson.est","FGFR inhibitor",0.41466,1.15,0.279,224,0.703,"orantinib, erdafitinib, lenvatinib, nintedanib",0.554395796726402,0.153044674980176,FALSE +"H460","Pearson.est","FLT3 inhibitor",0.21229,0.592,0.949,208,0.928,"GTP.14564, TG.02, TG.101348, sorafenib",0.0227337875727074,0.0324520237811379,FALSE +"H460","Pearson.est","glucocorticoid receptor agonist",0.49779,1.33,0.16,395,0.716,"hydrocortisone, piretanide, triamcinolone, halcinonide, triamcinolone.acetonide, difluprednate, deflazacort, betamethasone, dexamethasone.acetate, prednisolone.hemisuccinate, flumethasone.pivalate",0.795880017344075,0.145086977692144,FALSE +"H460","Pearson.est","glutamate receptor antagonist",-0.20201,-0.508,0.97,1234,0.996,"diazooxonorleucine, SIB.1757",0.0132282657337552,0.00174066157630127,FALSE +"H460","Pearson.est","glycogen synthase kinase inhibitor",-0.41954,-1.03,0.418,1158,0.835,"tideglusib, LY2090314, kenpaullone",0.378823718224965,0.0783135245163979,FALSE +"H460","Pearson.est","growth factor receptor inhibitor",-0.78134,-1.92,0.00322,1147,0.185,"danusertib, AZD3463, lestaurtinib, GSK1838705A, PHA.848125, GW.441756",2.49214412830417,0.732828271596986,TRUE +"H460","Pearson.est","HCV inhibitor",-0.35267,-0.911,0.534,1343,0.809,"daclatasvir",0.272458742971444,0.0920514783877277,FALSE +"H460","Pearson.est","HDAC inhibitor",-0.41361,-1.06,0.376,1050,0.801,"JNJ.26481585, dacinostat, romidepsin, PCI.24781, entinostat, panobinostat, AR.42, givinostat, R306465, tacedinaline, chidamide",0.424812155072339,0.0963674839157623,FALSE +"H460","Pearson.est","histamine receptor antagonist",-0.26424,-0.659,0.87,1082,0.965,"cyproheptadine, levocetirizine, astemizole, pheniramine, ranitidine, terfenadine, zolantidine",0.0604807473813815,0.0154726866562074,FALSE +"H460","Pearson.est","HMGCR inhibitor",-0.30154,-0.751,0.768,907,0.889,"simvastatin, fluvastatin, mevastatin, pitavastatin",0.114638779968488,0.0510982390297863,FALSE +"H460","Pearson.est","HSP inhibitor",-0.50524,-1.29,0.182,1202,0.748,"NVP.AUY922, ganetespib, PU.H71, SNX.2112, SNX.5422, BIIB021",0.739928612014925,0.126098402135539,FALSE +"H460","Pearson.est","JAK inhibitor",-0.21675,-0.545,0.96,1059,1,"ruxolitinib, tozasertib, baricitinib, lestaurtinib, WHI.P154",0.0177287669604316,0,FALSE +"H460","Pearson.est","KIT inhibitor",0.33211,0.886,0.54,247,0.789,"cediranib, lenvatinib, telatinib, sorafenib, motesanib",0.267606240177031,0.10292299679058,FALSE +"H460","Pearson.est","MDM inhibitor",-0.74864,-1.91,0.00479,1265,0.104,"CGM097, serdemetan, idasanutlin, nutlin.3",2.31966448658544,0.98296666070122,TRUE +"H460","Pearson.est","MEK inhibitor",-0.59967,-1.56,0.0628,1091,0.393,"arctigenin, nobiletin, PD.198306, AZD8330, refametinib, TAK.733, cobimetinib, MEK162, PD.184352, PD.0325901, Ro.4987655, AS.703026, PD.98059, trametinib",1.2020403562628,0.405607449624573,FALSE +"H460","Pearson.est","MET inhibitor",-0.44207,-1.14,0.31,736,0.735,"LY2801653, NVP.BVU972, INC.280, PHA.665752, PF.04217903",0.508638306165727,0.133712660915805,FALSE +"H460","Pearson.est","microtubule inhibitor",0.2736,0.755,0.743,239,0.789,"triclabendazole, colchicine, cytochalasin.b",0.129011186239425,0.10292299679058,FALSE +"H460","Pearson.est","mTOR inhibitor",-0.46411,-1.16,0.298,1189,0.731,"GDC.0980, MLN0128, AZD2014, PI.103, sirolimus, NVP.BEZ235, ku.0063794, LY303511, PP242",0.525783735923745,0.13608262304214,FALSE +"H460","Pearson.est","NFkB pathway inhibitor",0.38233,1.02,0.392,227,0.887,"tyloxapol, parthenolide, IKK.2.inhibitor.V",0.406713932979543,0.0520763801682736,FALSE +"H460","Pearson.est","opioid receptor agonist",-0.40185,-1.02,0.419,967,0.824,"salvinorin.a, spiradoline, BW.180C",0.377785977033705,0.0840727883028842,FALSE +"H460","Pearson.est","p38 MAPK inhibitor",-0.29351,-0.749,0.768,1098,0.871,"VX.702, CMPD.1",0.114638779968488,0.0599818449923368,FALSE +"H460","Pearson.est","PARP inhibitor",-0.71983,-1.82,0.00835,1384,0.161,"niraparib, talazoparib, olaparib",2.0783135245164,0.79317412396815,TRUE +"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.35308,0.932,0.509,247,0.803,"linifanib, orantinib, lenvatinib, telatinib, sorafenib, nintedanib, motesanib",0.293282217663241,0.095284454721319,FALSE +"H460","Pearson.est","phosphatase inhibitor",0.30559,0.849,0.599,214,0.797,"GSK2830371, menadione, BVT.948",0.222573177610689,0.0985416786038876,FALSE +"H460","Pearson.est","phosphodiesterase inhibitor",-0.48668,-1.21,0.236,1143,0.693,"zardaverine, EMD.53998, papaverine, GSK256066, YM.976, trequinsin",0.627087997029893,0.159266765388193,FALSE +"H460","Pearson.est","PI3K inhibitor",-0.34873,-0.867,0.616,1182,0.793,"alpelisib, GDC.0980, TG.100713, PI.103, PIK.75, NVP.BEZ235, LY303511",0.210419287835575,0.100726812682396,FALSE +"H460","Pearson.est","PLK inhibitor",-0.6662,-1.67,0.0268,960,0.287,"rigosertib, volasertib, GW.843682X, NMS.1286937, BI.2536, HMN.214, GSK461364",1.57186520597121,0.542118103266008,FALSE +"H460","Pearson.est","potassium channel blocker",-0.35215,-0.889,0.567,1285,0.779,"oleoylethanolamide, meglitinide",0.246416941107093,0.108462542327436,FALSE +"H460","Pearson.est","PPAR receptor agonist",0.5819,1.58,0.0575,143,0.481,"GW.501516, fenofibrate, pterostilbene, S26948",1.24033215531037,0.317854923626168,FALSE +"H460","Pearson.est","progesterone receptor agonist",0.48323,1.32,0.182,515,0.658,"norgestrel, melengestrol.acetate, norethindrone, nomegestrol.acetate, tanaproget, danazol",0.739928612014925,0.181774106386044,FALSE +"H460","Pearson.est","proteasome inhibitor",0.21806,0.607,0.923,1134,0.943,"carfilzomib, oprozomib, ONX.0914, ixazomib.citrate, bortezomib, MG.132, ixazomib, delanzomib",0.0347982989740879,0.0254883072626717,FALSE +"H460","Pearson.est","protein synthesis inhibitor",-0.36099,-0.904,0.593,1040,0.775,"chloramphenicol.palmitate, emetine, homoharringtonine, mercaptopurine, cycloheximide, thiostrepton, brefeldin.a",0.226945306635737,0.11069829749369,FALSE +"H460","Pearson.est","protein tyrosine kinase inhibitor",0.365,0.996,0.441,534,0.888,"CP.724714, rheochrysidin, PP.121, BMS.599626, AV.412",0.355561410532161,0.051587034221399,FALSE +"H460","Pearson.est","RAF inhibitor",-0.34129,-0.855,0.636,1079,0.771,"CEP.32496, regorafenib, RAF265, vemurafenib, SB.590885, LGX818",0.196542884351586,0.112945621949043,FALSE +"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.23976,-0.614,0.909,1058,0.99,"cabozantinib, regorafenib",0.0414361167780325,0.00436480540245009,FALSE +"H460","Pearson.est","retinoid receptor agonist",0.31573,0.857,0.591,12,0.813,"fenretinide",0.228412519118745,0.0899094544059319,FALSE +"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.56398,-1.43,0.0953,1141,0.564,"gemcitabine, cladribine, clofarabine, hydroxyurea, fludarabine.phosphate, fludarabine",1.02090709936167,0.248720896016658,FALSE +"H460","Pearson.est","serotonin receptor agonist",-0.37849,-0.972,0.492,1447,0.802,"aripiprazole",0.30803489723264,0.0958256317158365,FALSE +"H460","Pearson.est","serotonin receptor antagonist",-0.40208,-1.01,0.437,1066,0.814,"SB.216641, RS.16566, SB.228357, ziprasidone, SB.200646, aripiprazole",0.359518563029578,0.0893755951107988,FALSE +"H460","Pearson.est","sodium channel blocker",-0.2157,-0.539,0.949,1063,1,"ajmaline, butamben, brivaracetam, mexiletine",0.0227337875727074,0,FALSE +"H460","Pearson.est","src inhibitor",0.45249,1.23,0.239,109,0.652,"ZM.306416, PP.1",0.621602099051862,0.18575240426808,FALSE +"H460","Pearson.est","sterol demethylase inhibitor",-0.38757,-0.979,0.478,1268,0.849,"ketoconazole, lanoconazole",0.320572103387881,0.0710923097560473,FALSE +"H460","Pearson.est","TGF beta receptor inhibitor",0.83628,2.3,0,156,0.011,"SB.431542, adaprev, SB.525334, repsox",Inf,1.95860731484178,TRUE +"H460","Pearson.est","thymidylate synthase inhibitor",-0.6704,-1.71,0.0217,1352,0.272,"carmofur, raltitrexed",1.66354026615147,0.565431095965801,FALSE +"H460","Pearson.est","topoisomerase inhibitor",-0.64183,-1.61,0.0473,1307,0.348,"voreloxin, topotecan, nemorubicin, irinotecan, SN.38, TAS.103, camptothecin, amonafide, valrubicin, rubitecan, exatecan.mesylate, mitoxantrone, genz.644282, amsacrine",1.32513885926219,0.458420756053419,FALSE +"H460","Pearson.est","tubulin polymerization inhibitor",-0.45879,-1.13,0.33,1014,0.721,"oxibendazole, ABT.751, vinblastine, podophyllotoxin, epothilone.b, fosbretabulin, verubulin, KX2.391, combretastatin.A.4, taltobulin, mebendazole, BNC105",0.481486060122112,0.142064735280571,FALSE +"H460","Pearson.est","tyrosine kinase inhibitor",-0.17593,-0.438,0.99,1341,0.993,"bafetinib, AMG.208",0.00436480540245009,0.00305075150461883,FALSE +"H460","Pearson.est","VEGFR inhibitor",0.35008,0.933,0.497,254,0.881,"cediranib, ZM.306416, linifanib, orantinib, lenvatinib, telatinib, sorafenib, nintedanib, motesanib, BMS.690514",0.303643611266668,0.0550240915879521,FALSE +"H460","Pearson.est","vitamin D receptor agonist",0.33922,0.887,0.583,87,0.821,"alfacalcidol, paricalcitol",0.234331445240986,0.0856568428805592,FALSE +"H520","Pearson.est","EGFR inhibitor",0.2953,0.77,0.716,446,0.928,"WZ.3146, vandetanib, WZ8040, pelitinib, CNX.2006, icotinib, AST.1306, rociletinib, canertinib, CGP.52411, BMS.690514, afatinib, BIBU.1361, erlotinib, tyrphostin.AG.494, PD.168393, BIBX.1382, osimertinib, poziotinib, OSI.420, dacomitinib",0.145086977692144,0.0324520237811379,FALSE +"H520","Pearson.est","Abl kinase inhibitor",0.46455,1.21,0.245,122,0.752,"flumatinib, KW.2449, ZM.306416",0.610833915635468,0.123782159408358,FALSE +"H520","Pearson.est","acetylcholine receptor agonist",0.30794,0.812,0.667,334,0.938,"nefiracetam, xanomeline",0.175874166083451,0.0277971616209356,FALSE +"H520","Pearson.est","acetylcholine receptor antagonist",0.29304,0.774,0.716,383,0.948,"iododexetimide, dicycloverine, methscopolamine",0.145086977692144,0.0231916626619338,FALSE +"H520","Pearson.est","adenosine receptor antagonist",0.60499,1.54,0.0795,412,0.564,"theophylline, MRS.1220, sulmazole, istradefylline, CGS.15943",1.09963287134353,0.248720896016658,FALSE +"H520","Pearson.est","adrenergic receptor agonist",0.50026,1.3,0.187,288,0.774,"oxymetazoline, A61603, terbutaline, norepinephrine, clenbuterol, buphenine, midodrine, isoetharine",0.728158393463501,0.111259039317107,FALSE +"H520","Pearson.est","adrenergic receptor antagonist",-0.34977,-0.909,0.56,1323,0.748,"naftidrofuryl, prazosin, idazoxan, vincamine",0.2518119729938,0.126098402135539,FALSE +"H520","Pearson.est","AKT inhibitor",0.44477,1.12,0.332,186,0.862,"AT7867, palomid.529, CCT128930, MK.2206",0.478861916295964,0.0644927341752872,FALSE +"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.39327,-1.04,0.394,1252,0.559,"AZD3463, CEP.37440, crizotinib",0.404503778174426,0.252588192113577,FALSE +"H520","Pearson.est","androgen receptor antagonist",0.35,0.92,0.509,319,0.939,"bicalutamide, RU.58841",0.293282217663241,0.0273344077338891,FALSE +"H520","Pearson.est","antioxidant",0.38898,1.01,0.415,23,0.894,"benfotiamine",0.381951903287907,0.0486624812040823,FALSE +"H520","Pearson.est","AP inhibitor",0.47856,1.25,0.235,63,0.832,"birinapant",0.628932137728264,0.0798766737092761,FALSE +"H520","Pearson.est","ATPase inhibitor",-0.49169,-1.27,0.193,1298,0.435,"omeprazole, digitoxigenin, NMS.873, rabeprazole, digoxin",0.714442690992226,0.361510743045363,FALSE +"H520","Pearson.est","Aurora kinase inhibitor",0.20248,0.517,0.976,436,0.971,"KW.2449, ZM.447439, CYC116, hesperadin, MLN.8054, alisertib, GSK1070916, SNS.314, AT.9283",0.0105501823333082,0.0127807700919951,FALSE +"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.46229,-1.19,0.265,1090,0.501,"radezolid, tedizolid, dirithromycin, azithromycin, azalomycin.b",0.576754126063192,0.300162274132754,FALSE +"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.63495,1.66,0.0333,302,0.461,"trovafloxacin, novobiocin, sparfloxacin, finafloxacin",1.47755576649368,0.336299074610352,FALSE +"H520","Pearson.est","BCL inhibitor",0.41446,1.07,0.351,554,0.884,"ABT.737, TW.37, HA14.1, gossypol, oridonin",0.454692883534176,0.0535477349869269,FALSE +"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.27323,0.687,0.838,282,0.932,"flumatinib, dasatinib",0.0767559813697235,0.0305840876460186,FALSE +"H520","Pearson.est","benzodiazepine receptor agonist",0.5143,1.34,0.165,344,0.743,"lorazepam, temazepam, CGS.20625, gamma.aminobutyric.acid, nefiracetam, indiplon",0.782516055786094,0.129011186239425,FALSE +"H520","Pearson.est","bromodomain inhibitor",0.26976,0.694,0.829,1059,0.97,"bromosporine, PFI.1, I.BET151, OTX015, I.BET.762, JQ1....",0.0814454694497265,0.0132282657337552,FALSE +"H520","Pearson.est","calcium channel blocker",0.27305,0.693,0.825,231,0.947,"efonidipine.monoethanolate, mibefradil",0.0835460514500749,0.0236500209967266,FALSE +"H520","Pearson.est","CC chemokine receptor antagonist",-0.41589,-1.09,0.321,1055,0.51,"PF.04136309, SB.225002, UNBS.5162, navarixin, ZK811752",0.493494967595128,0.292429823902064,FALSE +"H520","Pearson.est","CDK inhibitor",-0.54512,-1.44,0.118,1069,0.371,"indisulam, PHA.793887, dinaciclib, alvocidib, ribociclib, JNJ.7706621, NU6027, abemaciclib, arcyriaflavin.a, AZD5438, BMS.387032, BMS.265246, PHA.848125",0.928117992693875,0.430626090384954,FALSE +"H520","Pearson.est","CHK inhibitor",0.35428,0.907,0.558,44,0.932,"AZD7762",0.253365801062421,0.0305840876460186,FALSE +"H520","Pearson.est","cyclooxygenase inhibitor",0.25017,0.628,0.918,394,0.934,"metoxibutropate, ketoprofen, piroxicam, indoprofen, tryptanthrin, FR.122047, phenylbutazone",0.0371573187987575,0.0296531237699066,FALSE +"H520","Pearson.est","cytochrome P450 inhibitor",0.7039,1.82,0.0198,298,0.638,"itraconazole, cobicistat, eplerenone, morin",1.70333480973847,0.195179321278838,FALSE +"H520","Pearson.est","DNA alkylating agent",-0.43882,-1.15,0.275,1109,0.539,"temozolomide, satraplatin, cyclophosphamide, melphalan, dacarbazine, mitomycin.c",0.560667306169737,0.268411234813261,FALSE +"H520","Pearson.est","DNA inhibitor",-0.59322,-1.53,0.0596,1221,0.348,"busulfan, melphalan, nimorazole, bendamustine, teroxirone, sangivamycin, metronidazole",1.22475374025976,0.458420756053419,FALSE +"H520","Pearson.est","DNA methyltransferase inhibitor",-0.42454,-1.09,0.369,1094,0.51,"disulfiram, SGI.1027, azacitidine, fdcyd, decitabine",0.43297363384094,0.292429823902064,FALSE +"H520","Pearson.est","DNA polymerase inhibitor",0.56362,1.45,0.108,342,0.556,"cephalomannine, menadione, cidofovir, famciclovir",0.96657624451305,0.254925208417942,FALSE +"H520","Pearson.est","DNA synthesis inhibitor",-0.33903,-0.853,0.628,1133,0.762,"altretamine, cyclocytidine, floxuridine, nelarabine, enocitabine, mitomycin.c",0.202040356262804,0.1180450286604,FALSE +"H520","Pearson.est","dopamine receptor antagonist",0.40137,1.01,0.418,257,0.894,"nemonapride, UH.232...., acetophenazine, clebopride, raclopride, lurasidone",0.378823718224965,0.0486624812040823,FALSE +"H520","Pearson.est","estrogen receptor agonist",0.28055,0.723,0.793,39,0.978,"PPT",0.100726812682396,0.00966114521239857,FALSE +"H520","Pearson.est","estrogen receptor antagonist",-0.59167,-1.55,0.07,1011,0.364,"tamoxifen, toremifene, raloxifene",1.15490195998574,0.438898616350944,FALSE +"H520","Pearson.est","FGFR inhibitor",-0.52363,-1.4,0.12,1311,0.396,"nintedanib, dovitinib, lenvatinib, regorafenib",0.920818753952375,0.402304814074488,FALSE +"H520","Pearson.est","FLT3 inhibitor",-0.43227,-1.11,0.317,1218,0.549,"sorafenib, ENMD.2076, lestaurtinib, pacritinib, tyrphostin.AG.1296, dovitinib, TG.101348",0.498940737782249,0.260427655549908,FALSE +"H520","Pearson.est","glucocorticoid receptor agonist",0.37651,0.977,0.478,474,0.926,"piretanide, hydrocortisone, deflazacort, prednisolone.hemisuccinate, flumethasone.pivalate, clobetasol.propionate, triamcinolone, fludroxycortide, prednisolone, fluocinolone.acetonide, rimexolone, methylprednisolone",0.320572103387881,0.0333890133180656,FALSE +"H520","Pearson.est","glutamate receptor antagonist",0.47641,1.21,0.266,232,0.752,"latrepirdine, JNJ.16259685, SIB.1757, LY456236, kynurenic.acid",0.575118363368933,0.123782159408358,FALSE +"H520","Pearson.est","glycogen synthase kinase inhibitor",0.46229,1.23,0.222,535,0.819,"LY2090314, indirubin, CHIR.99021, CHIR.98014, GSK.3.inhibitor.IX",0.653647025549361,0.0867160982395816,FALSE +"H520","Pearson.est","growth factor receptor inhibitor",-0.71483,-1.86,0.019,1252,0.218,"AZD3463, lestaurtinib, GW.441756, danusertib, PHA.848125",1.72124639904717,0.661543506395395,TRUE +"H520","Pearson.est","HCV inhibitor",0.41397,1.07,0.364,83,0.884,"Ro.9187",0.438898616350944,0.0535477349869269,FALSE +"H520","Pearson.est","HDAC inhibitor",0.31492,0.835,0.642,289,0.985,"romidepsin, RG2833, RGFP966, pyroxamide, nexturastat.a, mocetinostat, belinostat, JNJ.26481585",0.192464971931147,0.00656376950238827,FALSE +"H520","Pearson.est","histamine receptor antagonist",0.6157,1.54,0.0606,242,0.564,"chloropyramine, BF2.649, epinastine, ICI.162846, famotidine, terfenadine, lafutidine, pheniramine, tiotidine",1.21752737583371,0.248720896016658,FALSE +"H520","Pearson.est","HMGCR inhibitor",0.64774,1.73,0.0233,230,0.609,"pitavastatin, atorvastatin, fluvastatin",1.63264407897398,0.215382707367125,FALSE +"H520","Pearson.est","HSP inhibitor",0.2583,0.67,0.834,573,0.93,"KW.2478, VER.49009, alvespimycin, guanidine, SNX.5422, ganetespib, BIIB021, NVP.AUY922",0.0788339493622613,0.0315170514460649,FALSE +"H520","Pearson.est","JAK inhibitor",-0.50653,-1.32,0.179,1290,0.392,"lestaurtinib, pacritinib, LY2784544, baricitinib, TG.101348",0.747146969020107,0.406713932979543,FALSE +"H520","Pearson.est","KIT inhibitor",-0.32437,-0.844,0.65,1214,0.752,"OSI.930, sorafenib, pazopanib, lenvatinib, regorafenib",0.187086643357144,0.123782159408358,FALSE +"H520","Pearson.est","MDM inhibitor",0.37674,0.961,0.471,198,0.886,"RITA, serdemetan",0.326979092871104,0.0525662781129492,FALSE +"H520","Pearson.est","MEK inhibitor",0.27973,0.71,0.818,453,0.972,"PD.184352, U.0126, TAK.733, BIX.02188, refametinib, arctigenin, PD.98059, AZD8330",0.087246696328677,0.0123337350737254,FALSE +"H520","Pearson.est","MET inhibitor",-0.31873,-0.84,0.629,851,0.734,"NVP.BVU972, PF.04217903, PHA.665752, INC.280",0.201349354554731,0.134303940083929,FALSE +"H520","Pearson.est","microtubule inhibitor",-0.33497,-0.856,0.628,1004,0.783,"cabazitaxel, vinblastine, secnidazole, podophyllotoxin, D.64131, vinflunine",0.202040356262804,0.106238237942057,FALSE +"H520","Pearson.est","mTOR inhibitor",-0.52148,-1.37,0.124,1114,0.379,"WAY.600, voxtalisib, sirolimus, GSK2126458, OSI.027, XL388, WYE.125132, NVP.BEZ235, WYE.354, PP242, AZD8055, ku.0063794, MLN0128, AZD2014",0.906578314837765,0.421360790031928,FALSE +"H520","Pearson.est","NFkB pathway inhibitor",0.35054,0.905,0.563,238,0.903,"BAY.11.7085, tyloxapol, IKK.2.inhibitor.V",0.249491605148654,0.0443122496864942,FALSE +"H520","Pearson.est","opioid receptor agonist",0.5862,1.53,0.0857,10,0.441,"cebranopadol",1.0670191780768,0.355561410532161,FALSE +"H520","Pearson.est","p38 MAPK inhibitor",-0.6469,-1.67,0.0377,1447,0.289,"talmapimod",1.42365864979421,0.539102157243452,FALSE +"H520","Pearson.est","PARP inhibitor",-0.31794,-0.828,0.631,1143,0.728,"olaparib, niraparib, PJ.34",0.199970640755866,0.137868620686963,FALSE +"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30233,-0.789,0.699,1218,0.764,"sorafenib, crenolanib, pazopanib, nintedanib, dovitinib, lenvatinib, regorafenib",0.155522824254319,0.11690664142431,FALSE +"H520","Pearson.est","phosphatase inhibitor",0.25385,0.645,0.889,351,0.938,"menadione, mycophenolate.mofetil, CID.5458317",0.0510982390297863,0.0277971616209356,FALSE +"H520","Pearson.est","phosphodiesterase inhibitor",0.6023,1.53,0.0694,455,0.441,"papaverine, anagrelide, avanafil, GSK256066, YM.976, EMD.53998, enoximone",1.15864052954514,0.355561410532161,FALSE +"H520","Pearson.est","PI3K inhibitor",-0.33652,-0.869,0.609,992,0.789,"GDC.0941, PKI.179, PF.04691502, PIK.75, voxtalisib, GSK2126458, CUDC.907, alpelisib, YM.201636, NVP.BEZ235, PI3K.IN.2, idelalisib, CH5132799",0.215382707367125,0.10292299679058,FALSE +"H520","Pearson.est","PLK inhibitor",-0.79685,-2.09,0.0021,1232,0.0474,"GSK461364, HMN.214, volasertib, BI.2536, GW.843682X, NMS.1286937",2.67778070526608,1.32422165832591,TRUE +"H520","Pearson.est","potassium channel blocker",0.33669,0.879,0.605,482,0.925,"meglitinide, ibutilide, dofetilide, mepivacaine",0.218244625347531,0.0338582672609674,FALSE +"H520","Pearson.est","PPAR receptor agonist",0.38481,0.974,0.449,312,0.894,"S26948, fenofibrate",0.347753658996677,0.0486624812040823,FALSE +"H520","Pearson.est","progesterone receptor agonist",0.29853,0.779,0.722,281,0.968,"norgestrel, tanaproget, norethindrone",0.141462802430361,0.0141246426916063,FALSE +"H520","Pearson.est","proteasome inhibitor",0.31928,0.83,0.645,456,0.933,"ixazomib.citrate, ONX.0914, oprozomib",0.190440285364732,0.0301183562535,FALSE +"H520","Pearson.est","protein synthesis inhibitor",-0.56844,-1.47,0.0933,1217,0.361,"emetine, anguidine, tedizolid.phosphate, clofoctol, bruceantin, harringtonine, homoharringtonine, chloramphenicol.palmitate",1.0301183562535,0.442492798094342,FALSE +"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.28035,-0.727,0.766,1087,0.829,"BMS.599626, tyrphostin.A9, mubritinib",0.115771230367396,0.0814454694497265,FALSE +"H520","Pearson.est","RAF inhibitor",-0.59037,-1.56,0.0748,1156,0.407,"vemurafenib, sorafenib, SB.590885, RAF265, LGX818, AZ.628, regorafenib",1.12609840213554,0.39040559077478,FALSE +"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.43547,-1.13,0.325,1218,0.543,"sorafenib, regorafenib",0.488116639021126,0.265200170411153,FALSE +"H520","Pearson.est","retinoid receptor agonist",-0.50666,-1.32,0.159,1075,0.392,"bexarotene, adapalene, tamibarotene, adarotene, AM.580",0.798602875679548,0.406713932979543,FALSE +"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.41694,-1.09,0.362,1206,0.51,"hydroxyurea, fludarabine.phosphate, pentostatin",0.441291429466834,0.292429823902064,FALSE +"H520","Pearson.est","serotonin receptor agonist",0.64501,1.67,0.0379,1,0.582,"aripiprazole",1.42136079003193,0.235077015350112,FALSE +"H520","Pearson.est","serotonin receptor antagonist",0.46331,1.2,0.259,257,0.726,"aripiprazole, lerisetron, RS.16566, tropisetron, lurasidone",0.586700235918748,0.139063379299906,FALSE +"H520","Pearson.est","sodium channel blocker",0.21041,0.544,0.967,482,0.978,"quinidine, A.803467, lappaconite, ajmaline, benzethonium, mepivacaine",0.0145735259169983,0.00966114521239857,FALSE +"H520","Pearson.est","src inhibitor",0.32471,0.834,0.642,122,0.955,"PP.2, ZM.306416",0.192464971931147,0.0199966284162537,FALSE +"H520","Pearson.est","sterol demethylase inhibitor",-0.70024,-1.83,0.0162,1280,0.18,"sulconazole, chlormidazole, ketoconazole, lanoconazole",1.79048498545737,0.744727494896694,TRUE +"H520","Pearson.est","TGF beta receptor inhibitor",0.40364,1.03,0.402,239,0.934,"D.4476",0.39577394691553,0.0296531237699066,FALSE +"H520","Pearson.est","thymidylate synthase inhibitor",-0.69561,-1.8,0.0164,1108,0.17,"raltitrexed, carmofur, trifluridine, ftorafur",1.7851561519523,0.769551078621726,TRUE +"H520","Pearson.est","topoisomerase inhibitor",-0.45572,-1.2,0.228,1184,0.511,"camptothecin, genz.644282, amsacrine, nemorubicin, etoposide.phosphate, topotecan, mitoxantrone, dexrazoxane, SN.38",0.642065152999546,0.291579099865287,FALSE +"H520","Pearson.est","tubulin polymerization inhibitor",-0.53243,-1.38,0.143,917,0.393,"paclitaxel, vincristine, dolastatin.10, epothilone.b, docetaxel, vindesine, vinblastine, combretastatin.A.4, oxibendazole, CYT.997, verubulin, fenbendazole, ABT.751, podophyllotoxin, plinabulin, BNC105, taltobulin, KX2.391, mebendazole",0.844663962534938,0.405607449624573,FALSE +"H520","Pearson.est","tyrosine kinase inhibitor",-0.25292,-0.66,0.871,1087,0.863,"BMS.599626, tyrphostin.AG.99, bafetinib, tyrphostin.A9, sorafenib, mubritinib, tivantinib, regorafenib",0.0599818449923368,0.0639892042847904,FALSE +"H520","Pearson.est","VEGFR inhibitor",-0.25801,-0.68,0.86,1214,0.865,"OSI.930, sorafenib, ENMD.2076, RAF265, pazopanib, nintedanib, foretinib, dovitinib, lenvatinib, regorafenib",0.0655015487564323,0.0629838925351858,FALSE +"H520","Pearson.est","vitamin D receptor agonist",-0.58542,-1.51,0.08,1227,0.337,"calcitriol, maxacalcitol, doxercalciferol",1.09691001300806,0.472370099128661,FALSE diff --git a/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_venn_diagram.pdf b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_venn_diagram.pdf new file mode 100644 index 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b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/GSEA/GSEA_interactive_network.graph.html @@ -0,0 +1,5318 @@ + + + + +visNetwork + + + + + + + +
+
+
+ + + + diff --git a/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/GSEA/GSEA_mean_results.csv b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/GSEA/GSEA_mean_results.csv new file mode 100644 index 0000000..27d2044 --- /dev/null +++ b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/GSEA/GSEA_mean_results.csv @@ -0,0 +1,182 @@ +"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.671066666666667,1.25372128747448,0.000426182074797522,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.00213091037398761 +"KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.595533333333333,1.1644635715744,0.10538060181695,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1650",0.2107612036339 +"KEGG_O_GLYCAN_BIOSYNTHESIS",0.593666666666667,1.73656523330505,1.30448296897215e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,6,"H1650, H2009, H2126, H3255, H1299, H1703",3.35438477735696e-06 +"KEGG_SPLICEOSOME",0.544866666666667,1.10170166214858,0.0702248665386982,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.151223108390862 +"KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.527933333333333,1.51368700608182,1.78300678980218e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1650, H2009, H1703",1.88788954214348e-05 +"KEGG_ETHER_LIPID_METABOLISM",0.510133333333333,1.36421159160398,0.00022153062354379,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H1650, H2009, HCC15, H1299",0.00141196252453187 +"KEGG_SPHINGOLIPID_METABOLISM",0.499066666666667,1.20477096025206,0.0191483360923705,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H460",0.0485450774172773 +"KEGG_VIRAL_MYOCARDITIS",0.476933333333333,1.1351842812429,0.0484473424986856,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.112490195578313 +"KEGG_MISMATCH_REPAIR",0.4562,1.31209849368973,0.00312392037222046,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H358",0.0114756258571364 +"KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.445933333333333,1.12665722171302,0.0772475532879669,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1650",0.162256925794493 +"KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.4268,1.75512535978813,3.90704348207531e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,6,"HCC95, H2009, HCC15, H1299, H460, H520",6.7064447155462e-06 +"KEGG_CELL_ADHESION_MOLECULES_CAMS",0.4218,1.3733701093088,0.000761213320407723,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.00351329224803564 +"KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.4216,1.11629942219818,0.100978242437355,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.206546404985499 +"KEGG_ABC_TRANSPORTERS",0.404933333333333,1.42574313788918,0.00168316203119409,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H2126, H358, HCC15, H460",0.00673264812477634 +"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.388285714285714,1.69462895546586,1.47530814022101e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,5,"H1650, H2009, H2126, H358, HCC15",7.19281879832146e-07 +"KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.3882,0.920117554601429,0.7572091187989,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.885049619375338 +"KEGG_HOMOLOGOUS_RECOMBINATION",0.3702,1.16894343013558,0.0683533960586392,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.150511677944397 +"KEGG_PROTEASOME",0.363533333333333,0.98287594527973,0.609425235874158,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.761781544842697 +"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.3628,1.27145216189993,0.020464111084835,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, H358, HCC15",0.0511602777120874 +"KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.357666666666667,1.25015819951298,0.0128034339470889,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0349184562193333 +"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.347538461538462,1.52767861014594,0.0124461230963727,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, HCC44, H1703, H460, H520",13,4,"H2009, H2126, HCC15, H460",0.0349184562193333 +"KEGG_SELENOAMINO_ACID_METABOLISM",0.345,1.15678427424601,0.104142599652175,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.210625482442601 +"KEGG_CARDIAC_MUSCLE_CONTRACTION",0.3406,1.11980143648008,0.158927184909564,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.28323656716556 +"KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.3348,1.23347807902231,0.0228762241976909,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC15, H520",0.0549029380744581 +"KEGG_OTHER_GLYCAN_DEGRADATION",0.315666666666667,1.37681888354832,0.0011544930492352,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.00506850606981308 +"KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.314666666666667,1.42311407366615,0.000416775295504676,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.00213091037398761 +"KEGG_CITRATE_CYCLE_TCA_CYCLE",0.313133333333333,1.01377299985652,0.458354837744466,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.625029324197 +"KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.29,1.73812542700462,5.38240751787206e-07,"HCC827, HCC95, H1650, H1975, H2009, H3255, H358, H1299, H1703, H460, H520",11,3,"H358, H1299, H520",8.07361127680809e-06 +"KEGG_DILATED_CARDIOMYOPATHY",0.28,1.40528817583543,0.000506445531726697,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.00246378907326501 +"KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.274466666666667,1.35546043134884,0.00376030931188481,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.0135371135227853 +"KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.271,1.16437003200382,0.100937533549697,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.206546404985499 +"KEGG_PYRIMIDINE_METABOLISM",0.267666666666667,0.767341576638524,0.999504660123495,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.266066666666667,1.03914143590251,0.50616180580069,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.660211051044379 +"KEGG_ARACHIDONIC_ACID_METABOLISM",0.266,1.55640060946495,1.72156426113164e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1299, H1703",1.88788954214348e-05 +"KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.252733333333333,1.0967609758262,0.295335665109728,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.443003497664592 +"KEGG_FATTY_ACID_METABOLISM",0.236266666666667,1.1716406364378,0.118053474997529,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.223680268416371 +"KEGG_PROTEIN_EXPORT",0.233333333333333,1.0715536561905,0.468287274777629,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2126, H520",0.631330518007783 +"KEGG_PARKINSONS_DISEASE",0.2306,0.954130778697104,0.800212157429862,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.917440690046976 +"KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.227533333333333,1.16543228440086,0.137038529084978,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.249160961972687 +"KEGG_RNA_DEGRADATION",0.2268,0.862700842040358,0.972144204552248,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.225,1.17462516817676,0.142172924522516,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.255911264140528 +"KEGG_HUNTINGTONS_DISEASE",0.219866666666667,0.758205293219895,0.999211940353133,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.214333333333333,1.6541561796477,0.00245314496198085,"H1975, H2009, H2126, H3255, A549, H1703",6,2,"H2009, H2126",0.0091992936074282 +"KEGG_RIBOSOME",0.207133333333333,1.44952587650813,0.00022748285117458,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC15",0.00141196252453187 +"KEGG_RIBOFLAVIN_METABOLISM",0.205333333333333,1.55470652566727,6.36883715403337e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",5.1910931146388e-05 +"KEGG_DNA_REPLICATION",0.2044,1.34259284329135,0.00568311834312175,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.0196723327261907 +"KEGG_BASAL_TRANSCRIPTION_FACTORS",0.1936,1.16100029531189,0.172053004027568,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.297784045432329 +"KEGG_TASTE_TRANSDUCTION",0.171066666666667,1.44532134176189,0.000311366612587233,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, H1650, H1299, H460",0.00175143719580319 +"KEGG_ADHERENS_JUNCTION",0.1706,1.0273442739135,0.594536006222527,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.753637190986302 +"KEGG_TRYPTOPHAN_METABOLISM",0.169933333333333,1.36502336278629,0.00402253595459586,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H358, H1299, H520",0.014197185722103 +"KEGG_N_GLYCAN_BIOSYNTHESIS",0.149333333333333,1.08579810453395,0.408726180857809,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.565928558110812 +"KEGG_TIGHT_JUNCTION",0.1442,1.12278678805398,0.26004746309588,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.400073020147507 +"KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.141066666666667,1.43737173175143,0.000546682107846546,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.00258954682664153 +"KEGG_PURINE_METABOLISM",0.140333333333333,0.844700425904835,0.994520213682643,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_FOCAL_ADHESION",0.1352,1.14599384191813,0.184094398342539,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.306823997237565 +"KEGG_LYSOSOME",0.1334,1.23926837863544,0.048745751417269,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H3255",0.112490195578313 +"KEGG_ARGININE_AND_PROLINE_METABOLISM",0.132666666666667,1.15887899446384,0.18244461202891,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.306823997237565 +"KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.128066666666667,1.41091887316977,0.00156311584519203,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.00639456482124013 +"KEGG_GLYCEROLIPID_METABOLISM",0.1274,1.14553068176158,0.209877187255361,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.340341384738422 +"KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.1268,1.55134937577397,0.000325400486602347,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H1703",0.00177491174510371 +"KEGG_RNA_POLYMERASE",0.104066666666667,1.33016220636361,0.0121868800871744,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.0348196573919267 +"KEGG_CALCIUM_SIGNALING_PATHWAY",0.100533333333333,0.991397416829012,0.790022324675496,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.911564220779419 +"KEGG_ECM_RECEPTOR_INTERACTION",0.0853333333333332,1.61384132104857,1.20191109327206e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H2009, H1299, H1703, H460",1.54531426277836e-05 +"KEGG_BASAL_CELL_CARCINOMA",0.079,1.46966215748479,0.000245546677109744,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.00147328006265847 +"KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.0714000000000001,1.69878384229929,1.71994518615006e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"HCC95, H358, HCC15, H1299, H520",3.86987666883764e-06 +"KEGG_NOTCH_SIGNALING_PATHWAY",0.0688666666666667,1.1185900478898,0.309422039085118,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.452812740124564 +"KEGG_OXIDATIVE_PHOSPHORYLATION",0.0652,0.948735865695581,0.845887167877184,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.951623063861832 +"KEGG_PEROXISOME",0.0530666666666666,1.22113650030656,0.0705707839157357,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC15",0.151223108390862 +"KEGG_LONG_TERM_POTENTIATION",0.0485333333333333,0.918778759834929,0.95239959631585,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_NON_HOMOLOGOUS_END_JOINING",0.0358666666666667,1.33999013144909,0.00685695274264554,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0224409362486581 +"KEGG_LEISHMANIA_INFECTION",0.0221333333333334,1.30260754240247,0.0147954449774412,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0391644131755798 +"KEGG_BETA_ALANINE_METABOLISM",0.000733333333333401,1.32176021526851,0.00998730871744822,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, H358, H1299",0.0294707470350931 +"KEGG_GNRH_SIGNALING_PATHWAY",-0.00473333333333329,0.930174904187891,0.956338012963406,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.00646666666666668,0.857701818538243,0.995692009323155,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.00813333333333336,1.32298897882607,0.0064295596276342,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H2009, H358, H1299",0.0214710294257406 +"KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.0186,1.28254572739421,0.0180458086585579,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2126, H1299",0.0464035079791488 +"KEGG_PHENYLALANINE_METABOLISM",-0.019,1.59507299429928,6.63306342426068e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, HCC15, H1299, H520",5.1910931146388e-05 +"KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.0240000000000001,1.18978623530208,0.115004526323932,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.222589405788256 +"KEGG_GAP_JUNCTION",-0.0400666666666666,0.999390347495245,0.768552374418437,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.892512434808508 +"KEGG_APOPTOSIS",-0.0443333333333333,0.960622987341821,0.903804460103794,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.998066274961245 +"KEGG_LONG_TERM_DEPRESSION",-0.0611333333333334,0.914045627703459,0.970529640015843,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_BASE_EXCISION_REPAIR",-0.0684666666666666,1.13212530014928,0.307863235285446,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.452812740124564 +"KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.0713333333333334,1.69679052780185,2.14645829478055e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"HCC95, H358, HCC15, H1299, H520",2.14645829478055e-05 +"KEGG_LYSINE_DEGRADATION",-0.0741333333333333,1.08975671378436,0.486454890935122,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.639137812907459 +"KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.0758666666666667,0.897194346414474,0.980707634624924,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.0759333333333333,0.97243093523886,0.858707730805452,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.960045910217275 +"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.0765333333333333,1.16611068248667,0.223961608027633,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H520",0.353623591622579 +"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.0912666666666667,1.3454995071755,0.00812248060042913,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1703, H520",0.0247804492894448 +"KEGG_PYRUVATE_METABOLISM",-0.0932666666666667,1.0501283232244,0.599400430742815,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC15",0.754490052683264 +"KEGG_SMALL_CELL_LUNG_CANCER",-0.0990666666666667,1.16124615740817,0.180272984935311,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.30649421315758 +"KEGG_ALZHEIMERS_DISEASE",-0.0995333333333334,0.843619655893296,0.996041425215107,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_PRIMARY_IMMUNODEFICIENCY",-0.109,1.47902801093923,0.000208876564249226,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.00139251042832817 +"KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.116533333333333,1.13235714120506,0.23924678852022,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.374473234205562 +"KEGG_HISTIDINE_METABOLISM",-0.116866666666667,1.38316515214028,0.00189511352797835,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC15, H1299, H520",0.00741566163121962 +"KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.1172,1.40260860032808,0.0009363483501256,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, H358, HCC15",0.0042135675755652 +"KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.123733333333333,1.42138320291321,0.000403536004808347,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.00213091037398761 +"KEGG_OOCYTE_MEIOSIS",-0.133533333333333,1.00423537840394,0.704540767861799,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.84008352030222 +"KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.134866666666667,1.23720034563449,0.0551572381005017,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.124103785726129 +"KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.1436,1.15758441839647,0.191255446117642,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.315834681662162 +"KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.1442,1.09261712023406,0.318078952500197,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.458033691600284 +"KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.144533333333333,1.07241655464034,0.48540261925761,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.639137812907459 +"KEGG_PANCREATIC_CANCER",-0.146666666666667,0.934790248945617,0.924617650695373,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_GLUTATHIONE_METABOLISM",-0.158866666666667,1.31317814408223,0.0101778052018162,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0295484667149502 +"KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.1628,1.21792699757768,0.0685664310635586,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.150511677944397 +"KEGG_PATHWAYS_IN_CANCER",-0.180066666666667,0.90808680096962,0.957106780963963,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_ENDOCYTOSIS",-0.1846,1.00630787677387,0.729025288211259,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.861108689845029 +"KEGG_MAPK_SIGNALING_PATHWAY",-0.187066666666667,0.921563304287624,0.934570451523719,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_TYROSINE_METABOLISM",-0.192,1.50827811001249,5.65978375031642e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.000407504430022782 +"KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.192133333333333,1.04184663435834,0.518489098477848,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.671424731841818 +"KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.196933333333333,0.960552628636741,0.83185108990271,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.94744276237978 +"KEGG_OLFACTORY_TRANSDUCTION",-0.198733333333333,1.18631268262309,0.11012697044799,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.217734061607094 +"KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.199666666666667,1.10651387356009,0.317362301632942,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.458033691600284 +"KEGG_RENAL_CELL_CARCINOMA",-0.219733333333333,0.900459602224384,0.94635264703455,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.2246,1.67563181260937,4.42095301296459e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1650, H2126, H1299, H1703, H520",3.97885771166813e-05 +"KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.229733333333333,1.44143195006447,0.000267302268531937,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H358",0.00155207768824996 +"KEGG_BLADDER_CANCER",-0.2308,1.19553575557452,0.0775227534351468,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.162256925794493 +"KEGG_WNT_SIGNALING_PATHWAY",-0.232,0.886887253262781,0.967840805462783,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_PROPANOATE_METABOLISM",-0.236733333333333,1.24271255535546,0.0146935009650931,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H1299",0.0391644131755798 +"KEGG_CELL_CYCLE",-0.2402,0.908414490039809,0.939769760564196,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_ENDOMETRIAL_CANCER",-0.2454,1.09995167426314,0.245450588127686,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.380871602267099 +"KEGG_P53_SIGNALING_PATHWAY",-0.245933333333333,1.07180731654973,0.377073203335263,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.534434461420058 +"KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.252,1.12798188941895,0.221805649577764,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.353318733840686 +"KEGG_RETINOL_METABOLISM",-0.2554,1.44856489573055,0.000130277909206758,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.000901923986816018 +"KEGG_VIBRIO_CHOLERAE_INFECTION",-0.255733333333333,1.10063679403378,0.272683022649791,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.413373291151073 +"KEGG_VEGF_SIGNALING_PATHWAY",-0.2568,1.15866457613927,0.130985801712934,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.242409808081716 +"KEGG_AXON_GUIDANCE",-0.257666666666667,1.13278529466511,0.180491036637241,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.30649421315758 +"KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.267333333333333,1.05991580977431,0.405071546074489,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.565216110801613 +"KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.28,1.87513047165105,3.18385886523285e-10,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"HCC95, H358, HCC44, H1299, H1703",5.73094595741913e-08 +"KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.286666666666667,1.5820360600309,8.78931768647305e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC15, H1299, H520",1.21698244889627e-05 +"KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.299066666666667,1.29070769439907,0.00644130882772217,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H358",0.0214710294257406 +"KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.304466666666667,1.0126025074506,0.574692748461573,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.733650317184986 +"KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.337133333333333,1.34641231567805,0.00194327654864967,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.00744233571823277 +"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.337733333333333,1.36035181723945,0.00125522888097129,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H358",0.00526757774994115 +"KEGG_MELANOGENESIS",-0.3606,1.01565347015041,0.479263347284429,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.639017796379239 +"KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.367066666666667,1.59104078544592,4.09838288172268e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H358",6.7064447155462e-06 +"KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.374533333333333,0.909342059377208,0.836907773435473,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.94744276237978 +"KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.377066666666667,1.22405482292412,0.0300099902625001,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.071076292726974 +"KEGG_BUTANOATE_METABOLISM",-0.377266666666667,1.25245264904316,0.0126448660771294,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0349184562193333 +"KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.3778,1.27906105070422,0.00953831726644881,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0286149517993464 +"KEGG_SULFUR_METABOLISM",-0.381428571428571,2.06189180176793,1.17983138427951e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,7,"HCC95, H1650, H2126, H358, HCC15, HCC44, H1299",8.84873538209632e-05 +"KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.384533333333333,1.12226192936196,0.111286298154737,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.217734061607094 +"KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.386933333333333,1.07367383093661,0.217682213026563,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.34984641379269 +"KEGG_THYROID_CANCER",-0.391533333333333,1.25893463274461,0.00802769018660458,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0247804492894448 +"KEGG_INSULIN_SIGNALING_PATHWAY",-0.395666666666667,0.874851878619352,0.88238111571935,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.980423461910389 +"KEGG_TYPE_II_DIABETES_MELLITUS",-0.400133333333333,1.23535610057914,0.0167035201414305,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0435744003689491 +"KEGG_MELANOMA",-0.413466666666667,1.08474077658257,0.168905974345538,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.295175489147542 +"KEGG_ERBB_SIGNALING_PATHWAY",-0.4184,0.910869741353991,0.731942386368275,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.861108689845029 +"KEGG_MTOR_SIGNALING_PATHWAY",-0.424733333333333,1.09238346659735,0.131978673288934,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.242409808081716 +"KEGG_COLORECTAL_CANCER",-0.433533333333333,0.772008777398905,0.983006312437232,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495 +"KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.4388,0.920364151533822,0.704736730920196,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.84008352030222 +"KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.451466666666667,0.921761114595833,0.702468913866307,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.84008352030222 +"KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.457533333333333,0.922972748914124,0.660327274567269,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.808564009674207 +"KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.462266666666667,0.970501451140938,0.469990496739128,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.631330518007783 +"KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.49,1.21759452551801,0.00738525001672431,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0233218421580768 +"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.495,1.78343553505371,2.27077817176701e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,6,"H1650, H2009, H2126, H1299, H1703, H520",8.17480141836125e-07 +"KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.496,1.97662085388169,0.00125836579581927,"H1975, H3255, H358, A549, H1299",5,2,"H1975, H1299",0.00526757774994115 +"KEGG_PROSTATE_CANCER",-0.5206,0.902667934514127,0.614827059755361,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.763233591420448 +"KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.526333333333333,0.983546474075662,0.273285675816543,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.413373291151073 +"KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.5286,0.894814489952287,0.622747961979733,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.767771459975013 +"KEGG_GLIOMA",-0.538066666666667,0.952737594413868,0.389356790454249,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.547532986576288 +"KEGG_GALACTOSE_METABOLISM",-0.541,1.02375631866182,0.163081745998481,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.287791316467907 +"KEGG_PRION_DISEASES",-0.547,1.18303984958846,0.0207580110402963,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H460",0.0511841368116894 +"KEGG_ACUTE_MYELOID_LEUKEMIA",-0.549133333333333,0.912179874700995,0.54362039262065,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.698940504797978 +"KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.5544,0.85538001579916,0.691663425614035,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.84008352030222 +"KEGG_REGULATION_OF_AUTOPHAGY",-0.570733333333333,1.22561252713354,0.00725414015872706,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, H358",0.0233168790816227 +"KEGG_PPAR_SIGNALING_PATHWAY",-0.5758,1.12656780913154,0.0222274511862465,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0540667731557348 +"KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.5894,0.991905223007003,0.199551796192625,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.326539302860658 +"KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.6172,0.923371632349928,0.306708127863984,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.452812740124564 +"KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.646866666666667,0.895843725742599,0.346648937356579,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.495212767652256 +"KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.655533333333333,1.01025003034374,0.117222225311158,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.223680268416371 +"KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.6778,0.827376162507547,0.429927334736064,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.59073984925566 +"KEGG_NITROGEN_METABOLISM",-0.682,1.37821416540184,6.34573847655268e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, HCC44",5.1910931146388e-05 +"KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.717866666666667,0.933048220057453,0.121665004380268,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.228121883213003 +"KEGG_STEROID_BIOSYNTHESIS",-0.731333333333333,1.57573958447938,9.04268113610231e-10,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H2009, H2126, H3255, H1299, H1703",8.13841302249208e-08 +"KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.824571428571429,1.50016864253455,9.62880005554781e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,4,"HCC95, H358, HCC15, H1299",2.88864001666434e-06 +"KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.8725,1.52090956637497,1.59394812683833e-06,"HCC827, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",12,3,"H1975, H358, H520",1.88788954214348e-05 +"KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.992266666666667,1.21141590514492,2.42902792930391e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H1299",2.30118435407739e-05 +"KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-1.0094,1.28993841491976,4.08662823976643e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H2126, H358, A549, HCC44",6.7064447155462e-06 +"KEGG_LINOLEIC_ACID_METABOLISM",-1.0175,1.60813297543041,0.0521757312240981,"H1975, H3255, H358, H1299",4,1,"H1299",0.118881412915667 +"KEGG_FOLATE_BIOSYNTHESIS",-1.05066666666667,1.4263162676062,1.59840417740477e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"HCC95, H1650, H358, H1299, H1703",7.19281879832146e-07 +"KEGG_TYPE_I_DIABETES_MELLITUS",-1.74,NA,NA,"HCC15",1,0,"",NA diff --git a/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/GSEA/GSEA_results.csv b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/GSEA/GSEA_results.csv new file mode 100644 index 0000000..3228315 --- /dev/null +++ b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/GSEA/GSEA_results.csv @@ -0,0 +1,2659 @@ +"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"HCC827","Input","KEGG_ABC_TRANSPORTERS",0.54049,1.52,0.0709,1185,0.401,"ABCA12, ABCC3, ABCC2, ABCA3, ABCG2, ABCB7, ABCD3, TAP2",1.14935376481693,0.396855627379818,FALSE +"HCC827","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.39562,-1.23,0.188,5858,0.594,"RELA, BRAF, STAT5A, BAD, SOS1, CCND1, IKBKG, RPS6KB2, MAP2K1, MTOR, AKT1, CHUK, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, RPS6KB1, TCF7L1, AKT2, MAPK1, PIK3CB",0.72584215073632,0.226213555018806,FALSE +"HCC827","Input","KEGG_ADHERENS_JUNCTION",0.43356,1.23,0.187,1419,0.615,"EGFR, CDH1, CTNNB1, CTNND1, RAC2, TGFBR2, CTNNA1, CTNNA2, MET, LMO7, TJP1, PTPRF, PTPRJ, AFDN, RAC3, PARD3, SRC, NECTIN4",0.728158393463501,0.211124884224583,FALSE +"HCC827","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.38221,-1.13,0.294,5467,0.63,"STAT3, PTPN11, PRKAA1, PRKAG1, RELA, RXRG, ACACB, ADIPOR2, PRKCQ, IKBKG, ACSL1, MTOR, STK11, MAPK8, AKT1, NFKBIB, CHUK, AKT3, IKBKB, MAPK9, IRS2, AKT2, CPT1A",0.531652669587843,0.200659450546418,FALSE +"HCC827","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.30791,-0.902,0.524,6277,0.771,"ASS1, ADSL, ASL, CAD, PPAT, CPS1, NIT2, GLUD2",0.280668713016273,0.112945621949043,FALSE +"HCC827","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.26484,-0.779,0.693,7350,0.829,"MAPK3, IRS2, MAPK1, PIK3CB, ATP1B3",0.159266765388193,0.0814454694497265,FALSE +"HCC827","Input","KEGG_ALZHEIMERS_DISEASE",-0.24201,-0.73,0.779,6859,0.856,"NDUFS5, NDUFB3, NAE1, NDUFA6, ITPR2, NDUFA9, CASP3, NDUFB4, CAPN1, NDUFV3, MAPK3, NDUFS7, NDUFA2, IDE, GSK3B, NDUFB7, CASP9, MAPK1, ITPR1, ATP2A1, PSEN2, ATP2A3, MAPT, SNCA, MME, BID",0.108462542327436,0.0675262353228468,FALSE +"HCC827","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.3628,1.03,0.386,1945,0.687,"PARS2, MARS2, TARS2, AARS2, YARS2, WARS2, FARS2",0.413412695328245,0.16304326294045,FALSE +"HCC827","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.39724,-1.2,0.254,7420,0.615,"UAP1, GALK1, NPL, GNPDA2, HK3, PGM3, GCK, GNE",0.595166283380062,0.211124884224583,FALSE +"HCC827","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.59984,-1.84,0.0285,7111,0.433,"CASP3, ALS2, MAPK14, BCL2L1, BAX, SOD1, CASP9, NEFL, NEFM, PRPH, PRPH2, NEFH, BID",1.54515513999149,0.363512103646635,FALSE +"HCC827","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.48545,1.37,0.126,1185,0.493,"CTSS, B2M, IFI30, LGMN, TAPBP, CREB1, PSME2, TAP2",0.899629454882437,0.30715308072277,FALSE +"HCC827","Input","KEGG_APOPTOSIS",-0.27932,-0.855,0.603,5858,0.765,"RELA, ATM, PRKACB, BIRC2, BAD, RIPK1, APAF1, IKBKG, IRAK4, PRKAR2B, PRKAR1A, DFFB, AKT1, CHUK, CASP3, XIAP, CAPN1, TNFRSF10D, BCL2L1, AKT3, BAX, IKBKB, AKT2, CASP9, PIK3CB, BID",0.219682687859849,0.116338564846382,FALSE +"HCC827","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.62342,1.76,0.0292,1027,0.762,"PTGS2, PTGES, GGT7, EPHX2, ALOX5, GGT1, GPX6, GPX7, PLA2G12A",1.53461714855158,0.1180450286604,FALSE +"HCC827","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34364,0.991,0.426,796,0.753,"PRODH, PRODH2, OAT, GATM, AGMAT, ALDH1B1, LAP3",0.370590400897281,0.123205023799299,FALSE +"HCC827","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.60072,1.71,0.0381,545,0.472,"ITGB6, ITGA1, DSC2, ITGA3, ITGA2, ITGA5, DSG2, CTNNB1, ITGB1, CTNNA1, GJA1, CTNNA2, ITGAV",1.41907502432438,0.326058001365912,FALSE +"HCC827","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.52864,1.47,0.0989,786,0.429,"UGDH, ALDH1B1",1.00480370840282,0.367542707815276,FALSE +"HCC827","Input","KEGG_AXON_GUIDANCE",0.4022,1.13,0.288,1664,0.658,"EPHB2, SEMA4B, ITGB1, RAC2, NRP1, EPHA1, EFNA5, EFNB2, MET, CFL2, SEMA3A, CXCR4, EFNA1, PLXNB3, PLXNB2, RAC3, PLXNB1, GNAI1, GNAI3, ROBO1, SLIT1, SLIT3, GNAI2, KRAS, NRAS, NTN4",0.540607512240769,0.181774106386044,FALSE +"HCC827","Input","KEGG_BASAL_CELL_CARCINOMA",0.42377,1.22,0.196,338,0.614,"CTNNB1, TP53",0.707743928643524,0.211831628858832,FALSE +"HCC827","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.24193,-0.735,0.787,4917,0.868,"TAF6, GTF2A1, TAF6L, TAF1, GTF2F1, TAF10, GTF2H2, TAF12, GTF2H4, GTF2H1, GTF2F2, GTF2IRD1, TAF2, TBPL1",0.104025267640935,0.0614802748235081,FALSE +"HCC827","Input","KEGG_BASE_EXCISION_REPAIR",-0.37347,-1.09,0.304,6755,0.621,"MUTYH, LIG3, NTHL1, PARP1, FEN1, HMGB1, MPG",0.517126416391246,0.20690839982342,FALSE +"HCC827","Input","KEGG_BETA_ALANINE_METABOLISM",-0.29755,-0.899,0.535,6702,0.766,"ALDH7A1, ALDH2, SRM, EHHADH",0.271646217978772,0.115771230367396,FALSE +"HCC827","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.2539,0.723,0.799,2400,0.972,"ACOX3, SCD5, PECR, ACAA1, FADS1, ELOVL6, ACOT2, HADHA, ACOX1",0.0974532206860086,0.0123337350737254,FALSE +"HCC827","Input","KEGG_BLADDER_CANCER",0.4753,1.35,0.135,338,0.503,"CDKN2A, EGFR, CDH1, CDK4, TP53",0.869666231504994,0.298432014944073,FALSE +"HCC827","Input","KEGG_BUTANOATE_METABOLISM",0.36724,1.04,0.37,786,0.682,"ACSM3, ACADS, HMGCL, BDH2, ALDH1B1",0.431798275933005,0.166215625343521,FALSE +"HCC827","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.286,-0.869,0.612,6577,0.759,"MAP2K1, BLNK, NFAT5, AKT1, SYK, NFKBIB, CHUK, CD22, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, GSK3B, AKT2, MAPK1, PIK3CB, CD81, PLCG2",0.213248577854439,0.11975822410452,FALSE +"HCC827","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.23319,0.669,0.878,615,0.969,"TNNC1, EGFR, PLCB4, P2RX4, CAMK2D, ERBB3",0.0565054840938974,0.0136762229492347,FALSE +"HCC827","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.45321,1.29,0.157,2323,0.544,"TNNC1, COX6A1, COX7A2, COX7C, COX5B, COX5A, UQCRH, COX6B1, COX6C, COX7A2L, ATP2A2, COX4I1, SLC9A6, UQCRFS1, COX7B, UQCRB, ATP1B1, UQCRC2, UQCRC1",0.804100347590766,0.26440110030182,FALSE +"HCC827","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.39319,1.15,0.272,592,0.636,"ITGB2, CDH1, CDH15, CDH3, OCLN, CLDN6, CD274, CLDN3, CLDN4, ICAM1, ALCAM, ITGB1, F11R, SDC1, ITGAV, CD276, CNTN1",0.565431095965801,0.196542884351586,FALSE +"HCC827","Input","KEGG_CELL_CYCLE",0.25369,0.726,0.808,926,0.981,"CDKN2A, FZR1, CDK4, TP53, ZBTB17, TFDP2, TGFB2, E2F3, CDC20, CCNA2, CCNB1",0.0925886392254138,0.0083309926200515,FALSE +"HCC827","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.29394,0.84,0.639,1649,0.862,"CXCL5, CX3CL1, PLCB4, RAC2, LYN, GNG12, STAT1, GNG4, ARRB1, CXCR4, GNB3, GNAI1, PIK3R3, STAT2, GNAI3, GNB2, PARD3, PRKCB, RAP1A, GNAI2, KRAS, NRAS, ADCY9",0.1944991418416,0.0644927341752872,FALSE +"HCC827","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.26282,0.746,0.776,704,0.974,"CDKN2A, CDK4, TGFBR2, TP53, TGFB2, E2F3",0.110138278741812,0.0114410431213845,FALSE +"HCC827","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.36444,1.04,0.369,2236,0.682,"DLST, DLAT, SUCLG2, SDHC, OGDHL, PDHB, PDHA1, OGDH, SUCLG1, CS, MDH2, SDHA, SDHB",0.43297363384094,0.166215625343521,FALSE +"HCC827","Input","KEGG_COLORECTAL_CANCER",-0.25449,-0.758,0.752,6269,0.848,"MSH2, CCND1, APPL1, MAP2K1, SMAD4, MAPK8, AKT1, MSH6, SMAD2, CASP3, MAPK3, RAF1, AKT3, BAX, GSK3B, MAPK9, TCF7L1, AKT2, CASP9, MAPK1, PIK3CB",0.123782159408358,0.0716041477432862,FALSE +"HCC827","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.59971,1.71,0.0294,706,0.472,"CFB, SERPINA1, CFI, MBL2, SERPINC1, PROS1, PLAU, TFPI, SERPINF2, F3, F8",1.53165266958784,0.326058001365912,FALSE +"HCC827","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.27524,-0.815,0.658,7177,0.792,"SRM, MAT1A, AHCY, SDS, APIP",0.181774106386044,0.101274818410506,FALSE +"HCC827","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.52324,1.49,0.0855,993,0.423,"CXCL5, EGFR, CX3CL1, TGFBR2, TNFRSF10B, IL6ST, IL10RB, OSMR, MET, TNFRSF10A, LTBR, IL18, TGFB2, CXCR4, TNFRSF21, IL1RAP",1.06803388527183,0.373659632624958,FALSE +"HCC827","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.25404,-0.762,0.729,5858,0.85,"RELA, POLR3A, POLR3B, IRF3, RIPK1, POLR3D, IKBKG, NFKBIB, CHUK, TREX1, POLR3C, IKBKB, PYCARD",0.137272471682025,0.0705810742857073,FALSE +"HCC827","Input","KEGG_DILATED_CARDIOMYOPATHY",0.51379,1.45,0.0924,660,0.436,"ITGB6, TNNC1, ITGA1, ITGA3, ITGA2, ITGA5, ITGB1, ITGAV, TGFB2",1.03432802877989,0.360513510731414,FALSE +"HCC827","Input","KEGG_DNA_REPLICATION",-0.22458,-0.659,0.883,5811,0.942,"POLA2, MCM7, MCM2, PRIM1, RNASEH2A, PRIM2, RNASEH1, FEN1, RNASEH2C, RNASEH2B",0.0540392964224314,0.0259490972071227,FALSE +"HCC827","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.5855,1.71,0.0304,412,0.472,"EGFR, ETS2, ETS1, ETV6",1.51712641639125,0.326058001365912,FALSE +"HCC827","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.35448,-1.07,0.32,7065,0.631,"MGST2, GSTM2, GSTO1, GSTA4, ALDH3A1, GSTT2, GSTM4, MAOA, GSTM3, MAOB",0.494850021680094,0.199970640755866,FALSE +"HCC827","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.32803,-0.966,0.449,6831,0.69,"UMPS, GMPS, IMPDH1, CES1, CES2, TPMT, UCK2",0.347753658996677,0.161150909262745,FALSE +"HCC827","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.58515,1.67,0.0377,1235,0.302,"ITGB6, TNC, ITGA1, LAMB3, ITGA3, ITGA2, LAMC2, ITGA5, ITGB1, CD47, SDC1, ITGAV, LAMB1, ITGA6, SDC4, LAMA5, COL5A1, AGRN",1.42365864979421,0.519993057042849,FALSE +"HCC827","Input","KEGG_ENDOCYTOSIS",0.22512,0.644,0.907,1759,0.96,"EGFR, RAB11FIP1, RAB31, EPN3, EPN2, MET, ERBB3, RAB11A, ACAP1, ARRB1, CXCR4, RAB11B, EHD1, RAB11FIP5, STAM2, PLD2, PARD3, RAB5B, PSD, SRC, LDLR, CHMP2B, EHD4, PLD1, EHD3, CLTA, AGAP1, RAB22A, RUFY1, RAB5A",0.0423927129399047,0.0177287669604316,FALSE +"HCC827","Input","KEGG_ENDOMETRIAL_CANCER",0.38834,1.12,0.29,425,0.644,"EGFR, CDH1, CTNNB1, TP53, CTNNA1, CTNNA2",0.537602002101044,0.191114132640188,FALSE +"HCC827","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.26233,0.751,0.792,810,0.98,"EGFR, LYN, F11R, JUN, MET, TCIRG1, TJP1, ADAM17",0.101274818410506,0.00877392430750515,FALSE +"HCC827","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.28031,-0.831,0.617,5895,0.783,"BRAF, PAK3, STAT5A, NCK2, PTK2, CRK, BAD, CAMK2G, SOS1, NCK1, RPS6KB2, HBEGF, MAP2K1, MTOR, MAPK8, CBL, AKT1, SHC1, PLCG1, ABL2, MAPK3, RAF1, MAP2K2, AKT3, GSK3B, MAPK9, RPS6KB1, AKT2, MAPK1, CRKL, PIK3CB, PLCG2",0.209714835966758,0.106238237942057,FALSE +"HCC827","Input","KEGG_ETHER_LIPID_METABOLISM",0.58793,1.7,0.0258,1722,0.37,"LPCAT1, PLPP2, PLPP1, PAFAH2, PLA2G12A, PLD2, LPCAT4, PLD1, PLPP3, AGPS",1.58838029403677,0.431798275933005,FALSE +"HCC827","Input","KEGG_FATTY_ACID_METABOLISM",0.30824,0.894,0.552,1362,0.823,"ACADS, ACSL4, CPT2, ACADVL, ALDH1B1, ACOX3, ACAA1, ACADM",0.258060922270801,0.0846001647877302,FALSE +"HCC827","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.34275,-1.02,0.393,6577,0.66,"MAP2K1, MAPK8, AKT1, SYK, PLCG1, PRKCD, MAPK14, MAPK3, RAF1, MAP2K2, AKT3, MAPK9, AKT2, MAPK1, PIK3CB, PLCG2",0.405607449624573,0.180456064458131,FALSE +"HCC827","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.2418,0.692,0.85,552,0.978,"MARCKS, PLPP2, RAC2, LYN, MARCKSL1, AMPH, PLPP1, CFL2",0.0705810742857073,0.00966114521239857,FALSE +"HCC827","Input","KEGG_FOCAL_ADHESION",0.33014,0.941,0.498,545,0.815,"ITGB6, TNC, EGFR, ITGA1, LAMB3, ITGA3, ITGA2, LAMC2, ITGA5, CTNNB1, ITGB1, RAC2, JUN, MET, ITGAV",0.302770657240282,0.0888423912600234,FALSE +"HCC827","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.61361,-1.81,0.031,6548,0.42,"ALPI, ALPP, GGH, DHFR",1.50863830616573,0.3767507096021,FALSE +"HCC827","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.49287,-1.41,0.122,6011,0.416,"GMDS, ALDOA, PMM1, PFKFB4, ALDOC, PMM2, PFKL, PFKM, PFKFB3, MTMR6, PFKP, MTMR2, AKR1B1, HK3",0.913640169325252,0.380906669373257,FALSE +"HCC827","Input","KEGG_GALACTOSE_METABOLISM",-0.40012,-1.21,0.227,7624,0.614,"GALK1, PFKP, AKR1B1, HK3, GCK",0.643974142806877,0.211831628858832,FALSE +"HCC827","Input","KEGG_GAP_JUNCTION",-0.29238,-0.872,0.554,6779,0.763,"CDK1, ADCY5, ADCY6, ITPR2, CSNK1D, TUBA1B, TUBB1, TUBA3C, TUBB, MAPK3, RAF1, TUBB2A, MAP2K2, TUBB6, TUBAL3, MAPK1, ITPR1, TUBB2B",0.25649023527157,0.11747546204512,FALSE +"HCC827","Input","KEGG_GLIOMA",0.31413,0.893,0.542,704,0.811,"CDKN2A, EGFR, CDK4, TP53, CAMK2D, E2F3",0.266000713461613,0.090979145788844,FALSE +"HCC827","Input","KEGG_GLUTATHIONE_METABOLISM",-0.37778,-1.13,0.279,6961,0.63,"GGCT, MGST2, GSTM2, SRM, PGD, GSTO1, GSTA4, IDH2, RRM2B, GCLM, ANPEP, RRM2, RRM1, GSTT2, GSTM4, GSTM3",0.554395796726402,0.200659450546418,FALSE +"HCC827","Input","KEGG_GLYCEROLIPID_METABOLISM",0.38497,1.11,0.317,1248,0.648,"LPL, PLPP2, MGLL, PLPP1, ALDH1B1, GLA, GPAT3, MBOAT2, MBOAT1",0.498940737782249,0.188424994129407,FALSE +"HCC827","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33079,0.935,0.501,1567,0.812,"LPCAT1, PEMT, PLPP2, PLPP1, GPD2, GPAT3, PLA2G12A, CDS1, PLD2, LPCAT4, MBOAT2, MBOAT1, PISD, PLD1, PLPP3",0.300162274132754,0.0904439707588247,FALSE +"HCC827","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.33729,-0.995,0.398,7312,0.693,"PHGDH, SDS, GCAT, MAOA, MAOB",0.400116927926312,0.159266765388193,FALSE +"HCC827","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.27023,-0.815,0.678,6478,0.792,"ALDOC, BPGM, GPI, PFKL, ALDH7A1, ALDH2, PKLR, PFKM, PKM, PFKP, ACSS2, HK3, ALDH3A1, ACSS1, GCK",0.168770306132937,0.101274818410506,FALSE +"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.6485,-1.93,0.0252,7319,0.892,"CHST14, CHPF, CHST12",1.59859945921846,0.0496351456238769,FALSE +"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.31616,-0.967,0.458,5041,0.699,"HS3ST1, EXT1, B3GALT6, EXTL2, EXT2, GLCE",0.339134521996131,0.155522824254319,FALSE +"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.40808,-1.24,0.201,6954,0.595,"B3GNT2, B4GAT1, B4GALT4, ST3GAL1",0.696803942579511,0.22548303427145,FALSE +"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.63815,1.78,0.0317,1502,1,"GNS, HPSE, IDS, HEXB, SGSH, HEXA",1.49894073778225,0,FALSE +"HCC827","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.3095,-0.916,0.487,7834,0.766,"ST3GAL1",0.312471038785366,0.115771230367396,FALSE +"HCC827","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.59506,1.69,0.0325,1502,0.307,"B3GALT5, GLA, HEXB, HEXA",1.48811663902113,0.512861624522813,FALSE +"HCC827","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.44013,-1.28,0.191,6954,0.561,"B3GNT2, B4GAT1, B4GALT4, FUT3, ST3GAL4",0.718966632752272,0.251037138743839,FALSE +"HCC827","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.64256,-1.94,0.0179,7997,1,"PGAP1, PIGM, PIGX",1.74714696902011,0,FALSE +"HCC827","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.25109,-0.747,0.755,2075,0.857,"CS, MDH2, MTHFD1L, MTHFD1, ACO2, MTHFD2, ACO1, PGP, MDH1, GRHPR",0.122053048370812,0.0670191780768018,FALSE +"HCC827","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.22789,0.658,0.901,1649,0.957,"EGFR, PLCB4, JUN, CAMK2D, GNAQ, PLA2G12A, PLD2, MAP2K4, PRKCB, ITPR3, SRC, PLD1, KRAS, NRAS, ADCY9",0.045275209020937,0.0190880622231565,FALSE +"HCC827","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.24669,0.698,0.865,929,0.997,"CSNK1G1, LRP2",0.0629838925351858,0.00130484168834428,FALSE +"HCC827","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.42532,1.21,0.197,201,0.613,"ITGA1, ITGA3, ITGA2, ITGA5",0.705533773838407,0.212539525481585,FALSE +"HCC827","Input","KEGG_HISTIDINE_METABOLISM",-0.49187,-1.49,0.0806,7840,0.383,"METTL2B, ALDH3A1, BUD23, LCMT1, MAOA, MAOB",1.09366495819491,0.416801226031377,FALSE +"HCC827","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.20486,-0.607,0.948,6866,0.976,"BLM, TOP3B, MUS81",0.0231916626619338,0.0105501823333082,FALSE +"HCC827","Input","KEGG_HUNTINGTONS_DISEASE",0.23112,0.658,0.901,2330,0.957,"PLCB4, SOD2, COX6A1, TP53, COX7A2, CREB1, COX7C, ATP5PF, COX5B, COX5A, GNAQ, UQCRH, COX6B1, NDUFB1, DLG4, COX6C, COX7A2L, ATP5MC2, RCOR1, COX4I1, HTT, NDUFB10, CLTA, SDHC, POLR2D, SLC25A5, SLC25A31, UQCRFS1, CREB5, GPX1, CASP8, POLR2K, COX7B, TFAM, POLR2L, UQCRB, AP2B1, SDHA, SDHB, TAF4, UQCRC2, UQCRC1, CLTB",0.045275209020937,0.0190880622231565,FALSE +"HCC827","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.53826,1.54,0.0722,660,0.43,"ITGB6, TNNC1, ITGA1, ITGA3, ITGA2, ITGA5, ITGB1, ACE, ITGAV, TGFB2",1.14146280243036,0.366531544420413,FALSE +"HCC827","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.37439,-1.09,0.323,7479,0.621,"CDIPT, PLCD3, PIP5K1A, OCRL, IMPA2, ITPKB, PIK3CB, ITPK1, PLCG2, ITPKA",0.490797477668897,0.20690839982342,FALSE +"HCC827","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.39484,-1.17,0.279,5975,0.602,"TSC1, ACACB, PRKACB, EIF4E2, CRK, PHKG2, BAD, ACACA, INPP5D, PRKCI, SOS1, RPS6KB2, MAP2K1, PRKAR2B, MTOR, MAPK8, PRKAR1A, PHKB, CBL, AKT1, SHC1, PKLR, GYS1, RPTOR, MAPK3, RAF1, PPP1R3D, MAP2K2, AKT3, IKBKB, GSK3B, MAPK9, RPS6KB1, IRS2, AKT2, MAPK1, CRKL, PIK3CB, HK3, SORBS1, GCK",0.554395796726402,0.220403508742175,FALSE +"HCC827","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.5027,-1.53,0.0963,8256,0.387,"CD40",1.01637371287547,0.412289034981089,FALSE +"HCC827","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.25171,0.732,0.828,1605,0.985,"IRF9, IL6ST, STAT1, IL10RB, OSMR, STAM2, PIK3R3, STAT2, JAK1, IFNGR1, SPRY1, IL13RA1",0.0819696632151199,0.00656376950238827,FALSE +"HCC827","Input","KEGG_LEISHMANIA_INFECTION",0.59025,1.69,0.0353,1357,0.307,"PTGS2, ITGB2, ITGB1, MARCKSL1, JUN, STAT1, CYBA, TGFB2, NCF2, JAK1, PRKCB, IFNGR1",1.45222529461218,0.512861624522813,FALSE +"HCC827","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.37798,1.07,0.367,434,0.682,"ITGB2, OCLN, CLDN6, CLDN3, CLDN4, ICAM1, CTNNB1, CTNND1, ITGB1, RAC2, F11R, CTNNA1, CTNNA2, CYBA",0.435333935747911,0.166215625343521,FALSE +"HCC827","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.46478,-1.37,0.139,6702,0.453,"ALDH7A1, ALDH2, EHHADH",0.856985199745905,0.343901797987168,FALSE +"HCC827","Input","KEGG_LONG_TERM_DEPRESSION",0.28927,0.807,0.674,1585,0.915,"PLCB4, LYN, GNAQ, PLA2G12A, GNAI1, GNAI3, PRKCB, ITPR3, GNAI2, KRAS, NRAS",0.17134010346468,0.0385789059335517,FALSE +"HCC827","Input","KEGG_LONG_TERM_POTENTIATION",-0.17933,-0.545,0.987,6899,0.992,"RPS6KA1, ITPR2, MAPK3, RAF1, MAP2K2, MAPK1, ITPR1, CAMK4",0.00568284733036327,0.00348832784582135,FALSE +"HCC827","Input","KEGG_LYSINE_DEGRADATION",0.2399,0.683,0.857,2365,0.977,"TMLHE, PLOD2, DLST, PIPOX, ALDH1B1, SETDB1, EHMT1, SETD2, EHMT2, SETD1B, GCDH, OGDHL, OGDH, SETD1A, ECHS1, HADH, HADHA",0.0670191780768018,0.0101054362812269,FALSE +"HCC827","Input","KEGG_LYSOSOME",0.53598,1.53,0.0749,1582,0.415,"GNS, CTSS, NAPSA, CTSK, CTSO, CTSH, CTSC, AP1M2, IDS, NPC2, FUCA1, LGMN, GAA, AGA, SUMF1, CTSV, AP1B1, TCIRG1, AP1S1, GLA, AP1S3, GALC, PSAP, HEXB, CLN5, IGF2R, LAMP2, GGA3, CD63, ASAH1, SCARB2, M6PR, SGSH, HEXA, AP1G1, LAMP1",1.12551818230053,0.381951903287907,FALSE +"HCC827","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.26069,-0.793,0.702,7088,0.814,"RPS6KA5, CASP3, RELB, NFKB2, MAPK14, MAPKAPK2, MAPK3, RASA1, CD14, TAOK2, RAF1, FLNA, MAP3K11, PPP5C, MAP2K2, AKT3, IKBKB, MAPK9, STK4, AKT2, NLK, MAPK1, CRKL, HSPA2, HSPA1L, STMN1, FGFR1, MAPT, FLNB",0.153662887870195,0.0893755951107988,FALSE +"HCC827","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.63536,-1.9,0.0285,6310,0.504,"IAPP, PKLR, MNX1, GCK",1.54515513999149,0.297569463554475,FALSE +"HCC827","Input","KEGG_MELANOGENESIS",0.23385,0.671,0.872,1649,0.979,"CTNNB1, PLCB4, CAMK2D, CREB1, GNAQ, GNAI1, GNAI3, ASIP, PRKCB, GNAI2, KRAS, NRAS, ADCY9",0.0594835150674328,0.00921730819686218,FALSE +"HCC827","Input","KEGG_MELANOMA",0.40989,1.17,0.237,704,0.674,"CDKN2A, EGFR, CDH1, CDK4, TP53, MET, E2F3",0.625251653989896,0.17134010346468,FALSE +"HCC827","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.35663,-1.05,0.407,7065,0.63,"MGST2, GSTM2, GSTO1, GSTA4, AKR1C3, AKR1C1, ALDH3A1, GSTT2, GSTM4, GSTM3",0.39040559077478,0.200659450546418,FALSE +"HCC827","Input","KEGG_MISMATCH_REPAIR",-0.18696,-0.55,0.977,1543,1,"POLD4, SSBP1, RFC1, POLD3, RFC4, LIG1, RFC5, POLD2, POLD1, RFC2, MSH3, RFC3, RPA2, RPA1, PCNA, PMS2, RPA3, MLH3, MLH1, MSH2, MSH6",0.0101054362812269,0,FALSE +"HCC827","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.4814,-1.45,0.0955,5510,0.414,"PRKAA1, RHEB, MLST8, TSC2, RPS6, BRAF, TSC1, EIF4E2, RPS6KB2, MTOR, STK11, AKT1, RPS6KA1, RICTOR, RPTOR, MAPK3, AKT3, RPS6KB1, AKT2, MAPK1, PIK3CB",1.01999662841625,0.382999658879101,FALSE +"HCC827","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.27935,-0.878,0.58,7315,0.773,"TNFRSF10D, MAPK3, IFNAR1, RAF1, MAP2K2, MAPK1, PIK3CB, PRF1, ZAP70, BID, PLCG2",0.236572006437063,0.111820506081675,FALSE +"HCC827","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.31793,0.898,0.571,538,0.829,"P2RX4, CHRNE",0.243363891754152,0.0814454694497265,FALSE +"HCC827","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.38899,-1.15,0.262,6253,0.624,"MAP3K3, CAMK2G, SOS1, MAGED1, IRAK4, MAP2K1, MAP3K5, MAPK8, AKT1, SHC1, PLCG1, NFKBIB, RPS6KA1, PRKCD, RPS6KA5, ARHGDIA, MAPK14, MAPKAPK2, MAPK3, RAF1, MAP2K2, AKT3, BAX, IKBKB, GSK3B, MAPK9, IRS2, AKT2, MAPK1, CRKL, PIK3CB, CSK, CAMK4, NGFR, PLCG2",0.581698708680255,0.204815410317576,FALSE +"HCC827","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.32533,-0.981,0.443,8169,0.685,"NMNAT3, QPRT",0.35359627377693,0.164309428507574,FALSE +"HCC827","Input","KEGG_NITROGEN_METABOLISM",-0.58679,-1.75,0.0427,7138,0.407,"CPS1, CA12, CA1, CA8, GLUD2, CA2",1.36957212497498,0.39040559077478,FALSE +"HCC827","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.38359,-1.19,0.235,5818,0.616,"MAP3K7, RELA, BIRC2, TAB1, IKBKG, MAPK8, SUGT1, NFKBIB, CHUK, HSP90AB1, XIAP, MAPK14, MAPK3, IKBKB, TAB3, MAPK9, MAPK1, PYCARD",0.628932137728264,0.210419287835575,FALSE +"HCC827","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.50889,-1.52,0.0782,6148,0.38,"LIG4, PRKDC, NHEJ1, XRCC6, XRCC5, FEN1",1.10679324694015,0.42021640338319,FALSE +"HCC827","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.29756,0.854,0.606,338,0.862,"CDKN2A, EGFR, CDK4, TP53",0.217527375833714,0.0644927341752872,FALSE +"HCC827","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.45648,1.34,0.129,1537,0.499,"DLL3, DTX3L, RBPJ, NUMB, ADAM17, MAML3, NCSTN, DTX2, NOTCH2, NOTCH3",0.889410289700751,0.30189945437661,FALSE +"HCC827","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.29662,-0.893,0.537,5133,0.766,"PCNA, ERCC2, RAD23B, GTF2H5, RPA3, GTF2H2, CUL4B, GTF2H4, CETN2, CDK7, GTF2H1, ERCC1, ERCC6, CCNH, ERCC4, RAD23A, CUL4A, DDB2, XPC, XPA",0.270025714300444,0.115771230367396,FALSE +"HCC827","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.24031,0.693,0.843,2078,0.99,"ST6GAL1, FUT8, DOLPP1, MAN1A2, B4GALT1, RPN2, DPM1, ALG6, STT3A, ALG13, MAN2A1",0.0741724253752577,0.00436480540245009,FALSE +"HCC827","Input","KEGG_OLFACTORY_TRANSDUCTION",0.4055,1.15,0.265,2497,0.636,"CAMK2D, PDC, CAMK2B, PRKACA, CNGB1",0.576754126063192,0.196542884351586,FALSE +"HCC827","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.42156,-1.27,0.184,7990,0.56,"DHFR, TYMS",0.735182176990464,0.2518119729938,FALSE +"HCC827","Input","KEGG_OOCYTE_MEIOSIS",-0.36914,-1.11,0.304,5763,0.654,"SMC3, CDC26, SKP1, SMC1A, MAD2L1, ANAPC4, PRKACB, CCNB2, YWHAZ, PLK1, CAMK2G, PPP2R5C, PPP2R1B, ANAPC1, MAP2K1, PPP2R5A, SMC1B, CDC27, CDK1, ADCY5, PPP2CB, RPS6KA1, PPP2R5D, ADCY6, ITPR2, ANAPC7, PKMYT1, CUL1, MAPK3, CDC23, CDC16, ANAPC5, MAPK1, STAG3, ITPR1, CDK2, MAD2L2",0.517126416391246,0.184422251675733,FALSE +"HCC827","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.60295,1.7,0.0541,1907,0.37,"FUCA1, AGA, FUCA2, MAN2B2, HEXB, HEXA, MANBA, GBA",1.26680273489343,0.431798275933005,FALSE +"HCC827","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.22541,0.628,0.918,2323,0.964,"COX6A1, PPA2, COX7A2, COX11, COX17, TCIRG1, COX7C, ATP5PF, COX5B, COX5A, UQCRH, COX6B1, NDUFB1, COX6C, LHPP, COX7A2L, ATP5MC2, COX4I1, NDUFB10, SDHC, UQCRFS1, COX7B, UQCRB, SDHA, SDHB, ATP6V1C1, ATP6AP1, UQCRC2, UQCRC1",0.0371573187987575,0.0159229660971692,FALSE +"HCC827","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.62067,1.78,0.0267,1051,1,"GALNT4, GALNT8, GALNT13, GALNT7, GALNT5, GALNT3, GALNT6, GALNT15, GALNT2, C1GALT1C1",1.57348873863542,0,FALSE +"HCC827","Input","KEGG_P53_SIGNALING_PATHWAY",0.26742,0.775,0.733,559,0.949,"CDKN2A, CDK4, TP53, TNFRSF10B, RCHY1",0.134896025358872,0.0227337875727074,FALSE +"HCC827","Input","KEGG_PANCREATIC_CANCER",0.37719,1.07,0.33,751,0.682,"CDKN2A, EGFR, CDK4, RAC2, TGFBR2, TP53, STAT1, TGFB2, E2F3, RALB",0.481486060122112,0.166215625343521,FALSE +"HCC827","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.5803,-1.73,0.0461,6522,0.303,"PPCDC, COASY, ENPP1, PANK4, PANK1",1.33629907461035,0.518557371497695,FALSE +"HCC827","Input","KEGG_PARKINSONS_DISEASE",0.175,0.484,0.995,1852,0.995,"UBE2L6, UBA7, COX6A1, COX7A2, COX7C, ATP5PF, COX5B, COX5A, UQCRH, COX6B1, NDUFB1, COX6C, HTRA2, COX7A2L, ATP5MC2, COX4I1, NDUFB10, SDHC, SLC25A5, SLC25A31, UQCRFS1",0.00217691925427455,0.00217691925427455,FALSE +"HCC827","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.3019,-0.913,0.489,6006,0.76,"NCK2, ARPC4, YWHAZ, ROCK2, ARPC1B, EZR, NCK1, ACTB, ARPC3, ARPC2, ROCK1, ARPC5, TUBA1B, TUBB1, TUBA3C, TUBB, ACTG1, CD14, TUBB2A, TUBB6, WAS, TUBAL3, ARHGEF2, HCLS1, TUBB2B",0.31069114087638,0.119186407719209,FALSE +"HCC827","Input","KEGG_PATHWAYS_IN_CANCER",0.33588,0.947,0.467,751,0.818,"PTGS2, CDKN2A, EGFR, PML, CDH1, CDK4, LAMB3, ITGA3, ITGA2, ETS1, LAMC2, CTNNB1, ITGB1, RAC2, TGFBR2, TP53, CTNNA1, JUN, CTNNA2, STAT1, MET, ITGAV, TGFB2, E2F3, LAMB1, RALB",0.330683119433888,0.087246696328677,FALSE +"HCC827","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.50903,-1.54,0.0618,7333,0.392,"CRYL1, DCXR, AKR1B1",1.20901152491118,0.406713932979543,FALSE +"HCC827","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.56712,-1.68,0.0672,6180,0.337,"ALDOA, PGM2, ALDOC, PGLS, GPI, PFKL, PRPS1, PRPS1L1, PRPS2, PFKM, PGD, PFKP, TALDO1",1.17263072694617,0.472370099128661,FALSE +"HCC827","Input","KEGG_PEROXISOME",0.39293,1.12,0.303,1309,0.644,"SOD2, ACSL4, ACOT8, SCP2, HMGCL, DHRS4, NUDT12, EPHX2, PIPOX, PEX13, SLC27A2, ACOX3, PAOX, HACL1, PECR, ABCD3, ACAA1, PEX3, ECH1",0.518557371497695,0.191114132640188,FALSE +"HCC827","Input","KEGG_PHENYLALANINE_METABOLISM",-0.5462,-1.61,0.0517,7974,0.374,"ALDH3A1, MAOA, MAOB",1.28650945690606,0.42712839779952,FALSE +"HCC827","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.36504,-1.05,0.37,6827,0.63,"SYNJ1, PLCG1, INPP5A, ITPR2, PIP5K1C, DGKH, CDIPT, PLCD3, PIP5K1A, OCRL, IMPA2, ITPKB, ITPR1, DGKQ, PIK3CB, ITPK1, PLCG2, ITPKA",0.431798275933005,0.200659450546418,FALSE +"HCC827","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.36031,1.04,0.381,1755,0.682,"CP, ALAD, HMOX2, FTH1, ALAS1, HCCS",0.419075024324381,0.166215625343521,FALSE +"HCC827","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.33219,-0.986,0.424,7762,0.699,"ME1, FABP7, FADS2, SORBS1, GK, CPT1A, CYP27A1, EHHADH",0.372634143407267,0.155522824254319,FALSE +"HCC827","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.60303,-1.73,0.0325,7800,0.303,"AKR1D1, CYP27A1",1.48811663902113,0.518557371497695,FALSE +"HCC827","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.54231,-1.58,0.064,6426,0.388,"IKBKG, RFX5, JAK3, BLNK, ZAP70, CD40",1.19382002601611,0.411168274405793,FALSE +"HCC827","Input","KEGG_PRION_DISEASES",-0.59536,-1.74,0.0467,7092,0.345,"NOTCH1, MAPK3, MAP2K2, BAX, SOD1, MAPK1, C9, NCAM1",1.33068311943389,0.462180904926726,FALSE +"HCC827","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.35668,-1.07,0.333,6539,0.631,"ANAPC1, MAP2K1, MAPK8, AKT1, CDC27, CDK1, ADCY5, RPS6KA1, ADCY6, ANAPC7, HSP90AB1, PKMYT1, MAPK14, MAPK3, CDC23, RAF1, AKT3, MAPK9, CDC16, ANAPC5, AKT2, MAPK1, CDK2, PIK3CB, MAD2L2",0.47755576649368,0.199970640755866,FALSE +"HCC827","Input","KEGG_PROPANOATE_METABOLISM",-0.36247,-1.09,0.318,7705,0.621,"ACAT2, ACSS2, ACSS1, ACSS3, EHHADH",0.497572880015567,0.20690839982342,FALSE +"HCC827","Input","KEGG_PROSTATE_CANCER",-0.26497,-0.797,0.671,6273,0.817,"SOS1, CCND1, IKBKG, MAP2K1, MTOR, AKT1, CHUK, RB1, HSP90AB1, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, GSK3B, TCF7L1, AKT2, CASP9, MAPK1, CDK2, PIK3CB, FGFR1",0.173277479831008,0.0877779434675845,FALSE +"HCC827","Input","KEGG_PROTEASOME",0.36334,1.04,0.382,474,0.682,"PSMB10, PSMB9, PSMB8",0.417936637088291,0.166215625343521,FALSE +"HCC827","Input","KEGG_PROTEIN_EXPORT",0.19957,0.553,0.972,1782,0.991,"OXA1L, SRPRA, HSPA5, SRPRB",0.0123337350737254,0.00392634551472468,FALSE +"HCC827","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.59592,-1.78,0.0529,7909,0.409,"ATP1B3, GLUD2, CA2",1.27654432796481,0.388276691992658,FALSE +"HCC827","Input","KEGG_PURINE_METABOLISM",-0.35688,-1.09,0.297,6266,0.621,"PRIM1, NT5C2, POLR3D, ADSL, PAPSS1, NT5C, AMPD3, PRIM2, PRPS1, PRPS1L1, ADCY5, PKLR, AMPD2, POLR3C, PRPS2, ADCY6, PAICS, NME7, GMPS, PPAT, ENPP1, DCK, AK5, IMPDH1, ENTPD4, NT5C3A, PKM, ENTPD8, GMPR, NUDT2, PDE4D, PDE8A, NME4, RRM2B, RRM2, NUDT5, RRM1, POLR2F",0.527243550682788,0.20690839982342,FALSE +"HCC827","Input","KEGG_PYRIMIDINE_METABOLISM",-0.23456,-0.675,0.858,6831,0.93,"UMPS, POLR3C, NME7, DCK, CTPS2, ENTPD4, NT5C3A, ENTPD8, NUDT2, DUT, NME4, RRM2B, RRM2, UCK2, RRM1, TYMS, POLR2F",0.0665127121512946,0.0315170514460649,FALSE +"HCC827","Input","KEGG_PYRUVATE_METABOLISM",-0.36411,-1.09,0.309,6232,0.621,"ACACA, MDH1, GRHPR, PC, ALDH7A1, ALDH2, PKLR, GLO1, PKM, ACYP2, HAGH, ACAT2, ACSS2, ME1, AKR1B1, ACSS1",0.510041520575165,0.20690839982342,FALSE +"HCC827","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.32198,0.928,0.498,552,0.781,"ITGB6, PIP4K2C, ITGB2, EGFR, ITGA1, ITGA3, ITGA2, ITGA5, ITGB1, RAC2, GNG12, ITGAV, CFL2",0.302770657240282,0.1073489661227,FALSE +"HCC827","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.24024,-0.732,0.802,5510,0.863,"PRKAA1, ATG3, ATG7, ATG4B",0.0958256317158365,0.0639892042847904,FALSE +"HCC827","Input","KEGG_RENAL_CELL_CARCINOMA",-0.21373,-0.635,0.9,7197,0.96,"EGLN1, MAPK3, RAF1, MAP2K2, AKT3, AKT2, MAPK1, CRKL, PIK3CB",0.0457574905606751,0.0177287669604316,FALSE +"HCC827","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.40697,-1.17,0.272,7860,0.602,"ANPEP, MME",0.565431095965801,0.220403508742175,FALSE +"HCC827","Input","KEGG_RETINOL_METABOLISM",0.54332,1.56,0.0595,1049,0.43,"RDH10, DHRS3, DHRS4, PNPLA4, RDH11",1.22548303427145,0.366531544420413,FALSE +"HCC827","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.43527,-1.28,0.172,6704,0.561,"ACP2, ENPP1, MTMR6, TYR, MTMR2",0.764471553092451,0.251037138743839,FALSE +"HCC827","Input","KEGG_RIBOSOME",-0.5251,-1.57,0.0573,5682,0.377,"RPS25, RPL21, RPL34, RPL32, RPS28, RPL5, RPL36, RPS2, RPL28, RPS7, RPS8, RPS6, RPL17, RPL7, RPL10, RPL15, RPL6, RPL26, RPL35A, RPL3, RPL23A, RPL10A, RPL12, RPL19, RPLP0, RPL13A, RPS10, UBA52, RPL4, RPS26, RPS17, RPL30, RPS15, RPL7A, RPS11, RPS3A, RPL31, RPS24, RPL18A, RPS19, RPL9, RPS15A, RPS13, RPS9, RPS5, RPS16, RPS3, RPL14, RPS4X, RPS27L, RPL22, RPL8, RPL27A, RPS20, RPL35, RPS18, RPL26L1",1.24184537803261,0.423658649794207,FALSE +"HCC827","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.39221,-1.17,0.243,8272,0.602,"DDX3Y",0.614393726401688,0.220403508742175,FALSE +"HCC827","Input","KEGG_RNA_DEGRADATION",-0.14669,-0.447,0.997,1866,0.998,"HSPD1, LSM6, LSM2, LSM3, LSM8, HSPA9, XRN2, CNOT2, LSM7, PATL1, EXOSC5, DCP1B, ENO1, DCP1A, EXOSC1, DCP2, EDC3, LSM4, EXOSC2, TTC37, MTREX, SKIV2L, WDR61, EXOSC4, CNOT3, EXOSC3, EDC4, EXOSC7, ENO3, EXOSC8, CNOT7, DIS3, PAPOLG, CNOT10, ENO2, MPHOSPH6, EXOSC9, C1D, PAPOLA, EXOSC6, ZCCHC7, EXOSC10, CNOT4, CNOT1, PARN, XRN1, DCPS, CNOT9, DDX6, LSM1",0.00130484168834428,0.000869458712628891,FALSE +"HCC827","Input","KEGG_RNA_POLYMERASE",-0.30648,-0.892,0.541,8204,0.757,"POLR2F",0.266802734893431,0.120904120499927,FALSE +"HCC827","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.33493,-1.02,0.35,7042,0.66,"SEPHS2, MAT1A, AHCY, SEPHS1, METTL2B, BUD23, LCMT1",0.455931955649724,0.180456064458131,FALSE +"HCC827","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.43864,1.25,0.192,1123,0.599,"PTGS2, CDK4, LAMB3, ITGA3, ITGA2, LAMC2, ITGB1, TP53, ITGAV, E2F3, LAMB1, ITGA6, MAX, LAMA5, PIK3R3",0.71669877129645,0.222573177610689,FALSE +"HCC827","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.41152,1.16,0.255,2182,0.674,"STX17, VAMP8, STX18, STX3, STX6, BNIP1, STX8, STX12, GOSR1, VTI1B, SEC22B, SNAP47, STX7",0.593459819566045,0.17134010346468,FALSE +"HCC827","Input","KEGG_SPHINGOLIPID_METABOLISM",0.49217,1.41,0.11,2056,0.474,"PLPP2, PLPP1, UGT8, GLA, GALC, ASAH1, PLPP3, SPHK2, GBA, SMPD1, SPTLC1",0.958607314841775,0.324221658325915,FALSE +"HCC827","Input","KEGG_SPLICEOSOME",0.27832,0.778,0.706,3534,0.958,"HNRNPA1, SRSF7, SNRNP27, ACIN1, HNRNPM, SF3B5, PRPF40A, NCBP2, ZMAT2, HNRNPU, SART1, PRPF19, PRPF4, WBP11, SRSF5, TRA2A, SNRNP40, DHX38, CWC15, LSM6, SRSF6, LSM2, LSM3, U2AF2, CDC5L, U2AF1, SNRPF, SNRPG, SNRNP70, HNRNPA3, SRSF10, LSM8, BCAS2, SNRPB, RBM25, PRPF31, PRPF38B, SF3B6, SF3A1, PRPF38A, HSPA6, SRSF9, HNRNPC, SNRPC, TRA2B, SF3B2, SF3B3, HNRNPK, LSM7, PQBP1, DDX5, SNW1, SNRPA, TCERG1, DDX23, PUF60, SLU7, XAB2, PLRG1, EFTUD2, SRSF3, SF3A2, DDX39B, SNU13, SRSF1, SNRPD3, TXNL4A, RBM8A, PPIL1, PPIH, PHF5A, SF3A3",0.151195298948196,0.0186344909214556,FALSE +"HCC827","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.33452,0.949,0.481,846,0.83,"PGM2L1, GAA, UGDH, UXS1, PYGL",0.317854923626168,0.0809219076239261,FALSE +"HCC827","Input","KEGG_STEROID_BIOSYNTHESIS",-0.36869,-1.06,0.337,6533,0.637,"CYP51A1, LSS, CEL, LIPA, MSMO1, SOAT2, SQLE",0.472370099128661,0.19586056766465,FALSE +"HCC827","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.46991,-1.41,0.111,6750,0.416,"SRD5A1, CYP21A2, COMT, HSD17B2, SULT2B1, AKR1C3, AKR1D1, AKR1C1",0.954677021213343,0.380906669373257,FALSE +"HCC827","Input","KEGG_SULFUR_METABOLISM",-0.55821,-1.66,0.0366,7685,0.337,"SULT2B1, SULT1A1, CHST12",1.43651891460559,0.472370099128661,FALSE +"HCC827","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.51444,-1.5,0.0823,6007,0.386,"ACTN4, ACTN1, ACTN2, C4A, C9, CD40",1.08460016478773,0.413412695328245,FALSE +"HCC827","Input","KEGG_TASTE_TRANSDUCTION",0.48765,1.4,0.115,2777,0.468,"SCNN1A, GNB3, ITPR3, GNB1, PRKACA, KCNB1, CACNA1A",0.939302159646388,0.329754146925876,FALSE +"HCC827","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.64977,-1.92,0.0216,6772,0.617,"GGPS1, MVK, ACAT2, PMVK, HMGCS1, FDPS, IDI1",1.66554624884907,0.209714835966758,FALSE +"HCC827","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.31245,-0.93,0.486,6369,0.748,"PPP2R1B, RPS6KB2, SMAD1, SMAD4, ROCK1, SMAD5, PPP2CB, SMAD2, SMAD9, CUL1, MAPK3, INHBE, RPS6KB1, THBS2, MAPK1, ID1",0.313363730737707,0.126098402135539,FALSE +"HCC827","Input","KEGG_THYROID_CANCER",0.40571,1.15,0.262,338,0.636,"CDH1, CTNNB1, TP53",0.581698708680255,0.196542884351586,FALSE +"HCC827","Input","KEGG_TIGHT_JUNCTION",0.45473,1.31,0.153,1351,0.53,"CDK4, OCLN, EPB41L1, CLDN6, RAB3B, CLDN3, CLDN4, CTNNB1, CGN, F11R, TJP2, CTNNA1, CTNNA2, TJP3, TJP1, MPDZ, AFDN, PATJ, LLGL1, GNAI1, GNAI3, CASK, EXOC4, CLDN1, PARD3, PRKCB, SRC",0.815308569182401,0.275724130399211,FALSE +"HCC827","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.32552,-0.981,0.43,6198,0.685,"TAB1, IRF3, RIPK1, IKBKG, IRAK4, TRAF3, MAP2K1, MAPK8, AKT1, CHUK, MAPK14, MAPK3, IFNAR1, CD14, MAP2K2, AKT3, IKBKB, MAPK9, AKT2, MAPK1, PIK3CB, LBP, CD40",0.366531544420413,0.164309428507574,FALSE +"HCC827","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.47167,-1.44,0.116,7705,0.411,"ACAT2, AADAT, MAOA, MAOB, EHHADH",0.935542010773082,0.386158178123931,FALSE +"HCC827","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.63282,-1.87,0.0323,6598,0.464,"MTOR, MAPK8, PKLR, PRKCD, MAPK3, PKM, IKBKB, MAPK9, IRS2, MAPK1, PIK3CB, HK3, GCK",1.4907974776689,0.333482019445119,FALSE +"HCC827","Input","KEGG_TYROSINE_METABOLISM",-0.59036,-1.74,0.035,7770,0.345,"TYR, METTL2B, DCT, ALDH3A1, BUD23, LCMT1, MAOA, MAOB",1.45593195564972,0.462180904926726,FALSE +"HCC827","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.29288,-0.846,0.578,6273,0.773,"SOS1, NCK1, PRKCQ, IKBKG, MAP2K1, NFAT5, CBL, AKT1, PLCG1, NFKBIB, CHUK, MAPK14, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, GSK3B, MAPK9, AKT2, MAPK1, PIK3CB, ZAP70",0.238072161579471,0.111820506081675,FALSE +"HCC827","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.30347,-0.875,0.565,6766,0.768,"CDC27, FANCL, CUL7, HUWE1, UBE2F, UBE2E1, CDC34, CUL4A, ANAPC7, SAE1, MID1, DDB2, CUL1, UBE2Q1, PIAS1, PPIL2, XIAP, UBA1, UBE2E3, UBE2G2, CDC23, PIAS4, UBE2S, UBE2B, FBXW7, UBE3A, HERC1, PIAS2, RNF7, CDC16, UBE2L3, ANAPC5, UBA2, UBE2M, HERC4, FBXO2",0.247951552180562,0.114638779968488,FALSE +"HCC827","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.29309,0.849,0.638,2807,0.858,"PDHB, PDHA1, IARS2",0.195179321278838,0.0665127121512946,FALSE +"HCC827","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.37663,1.1,0.321,1450,0.652,"ACADS, IVD, HMGCL, ACAD8, DBT, ALDH1B1, MCCC1, AUH, ACAA1, HIBCH, HIBADH, MCCC2, ACADM, ALDH6A1",0.493494967595128,0.18575240426808,FALSE +"HCC827","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.29063,-0.86,0.595,6004,0.766,"ACTA2, PRKACB, PLCB1, ROCK2, MYH11, PRKCQ, MAP2K1, ROCK1, ADCY5, ADCY6, ITPR2, PRKCD, MAPK3, RAF1, MAP2K2, MAPK1, ITPR1, ARHGEF1, ARHGEF11, KCNMA1",0.22548303427145,0.115771230367396,FALSE +"HCC827","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.33272,0.934,0.499,2090,0.798,"ARHGDIB, RAB11A, CREB1, RAB11B, DYNC1LI2, RAB5B, DYNLL2, ADCY9, RAB5A, CREB5, RAB5C",0.30189945437661,0.0979971086492706,FALSE +"HCC827","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.28054,-0.844,0.64,7259,0.767,"MAPK14, MAPKAPK2, MAPK3, RAF1, MAP2K2, AKT3, AKT2, CASP9, MAPK1, PIK3CB, PLCG2",0.193820026016113,0.115204636051019,FALSE +"HCC827","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.20452,0.581,0.965,1059,0.989,"ERO1A, TJP2, TCIRG1, TJP1, SLC12A2, PDIA4",0.0154726866562074,0.0048037084028206,FALSE +"HCC827","Input","KEGG_VIRAL_MYOCARDITIS",0.32775,0.932,0.525,255,0.787,"ITGB2, CXADR, ICAM1, RAC2",0.279840696594043,0.104025267640935,FALSE +"HCC827","Input","KEGG_WNT_SIGNALING_PATHWAY",0.31177,0.892,0.579,678,0.799,"CTNNB1, LRP5, PLCB4, RAC2, TP53, JUN, CAMK2D, DAAM1, DAAM2, CHD8",0.237321436272564,0.0974532206860086,FALSE +"HCC95","Input","KEGG_ABC_TRANSPORTERS",0.39284,1.15,0.261,1732,0.639,"ABCC5, ABCC8, ABCC3, ABCC1, ABCC4, TAP1, ABCB10, TAP2, ABCB6, ABCC2",0.583359492661719,0.1944991418416,FALSE +"HCC95","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.28754,0.816,0.635,1460,0.809,"PML, IKBKB, KRAS, NRAS, RARA, HRAS, BAD, MYC, EIF4EBP1, STAT3",0.197226274708024,0.0920514783877277,FALSE +"HCC95","Input","KEGG_ADHERENS_JUNCTION",0.34188,0.996,0.424,1106,0.734,"NECTIN1, EGFR, YES1, IGF1R, PTPN6, RAC2, SMAD3, RAC3, SRC, CTNND1, ACTN4, MET",0.372634143407267,0.134303940083929,FALSE +"HCC95","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.29338,0.861,0.594,822,0.806,"SLC2A1, RXRA, IKBKB, IRS1, PCK2",0.226213555018806,0.0936649581949093,FALSE +"HCC95","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.32401,-0.965,0.446,7877,0.831,"CPS1, GPT, GLS, GLS2, GLUD2",0.350665141287858,0.080398976215889,FALSE +"HCC95","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.28782,0.844,0.607,1227,0.815,"ATP1B3, IRS1, KRAS, ATP1A3, ATP1B1, ATP1A1, ATP1A4, SFN",0.216811308924742,0.0888423912600234,FALSE +"HCC95","Input","KEGG_ALZHEIMERS_DISEASE",-0.32101,-0.935,0.493,6408,0.823,"FADD, COX7A2, COX4I1, NDUFS2, UQCRQ, NDUFA3, LPL, GSK3B, NDUFAB1, APH1A, NCSTN, CASP3, COX5A, NDUFB4, PPP3CC, MME, MAPK1, NDUFB7, COX6C, NDUFA2, EIF2AK3, MAPK3, COX7C, CAPN2, HSD17B10, CYCS, CALM2, PPP3R1, PPP3R2, PSEN2, COX7B, APOE, PSEN1, BACE2, ATP5MC2",0.30715308072277,0.0846001647877302,FALSE +"HCC95","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.34247,-1.02,0.39,5695,0.786,"PARS2, FARSB, TARS2, AARS2, LARS2, FARS2, YARS2, FARSA, EARS2, MARS2, CARS2",0.408935392973501,0.104577453960592,FALSE +"HCC95","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.40248,-1.19,0.234,6876,0.656,"UGP2, GMPPB, GALK1, CYB5R3, GALK2, GNPNAT1, PMM2, GMDS, AMDHD2, RENBP, NAGK, GALT, GNE, GCK, PGM1, UAP1",0.630784142589857,0.18309616062434,FALSE +"HCC95","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.32409,-0.967,0.462,7912,0.843,"NEFL, RAB5A, TOMM40L, MAP3K5, CYCS, PPP3R1, PPP3R2, NEFH, PRPH, PRPH2",0.335358024443874,0.0741724253752577,FALSE +"HCC95","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.38863,1.15,0.262,2128,0.639,"CTSB, TAPBP, B2M, NFYB, HSPA5, NFYA, TAP1, PSME1, TAP2, PSME2, HSPA1A, CANX, CTSL, NFYC, HSPA6, PSME3",0.581698708680255,0.1944991418416,FALSE +"HCC95","Input","KEGG_APOPTOSIS",-0.30823,-0.907,0.547,7082,0.827,"CASP3, AKT3, PPP3CC, IRAK4, CASP6, PRKACA, PRKAR2B, AIFM1, AKT1, EXOG, MYD88, CAPN2, PIK3CB, CYCS, PPP3R1, PPP3R2, PRKACB, RIPK1",0.262012673666569,0.0824944904474534,FALSE +"HCC95","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.43307,1.28,0.163,1264,0.621,"AKR1C3, CYP4F3, CBR1, EPHX2, GPX2, PTGS2, ALOX5, CBR3, PTGES2",0.787812395596042,0.20690839982342,FALSE +"HCC95","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34959,1.02,0.39,1592,0.732,"CKMT1A, CKMT2, ODC1, ASS1, PYCR2, SAT2, GATM, PYCR1, ARG1, P4HA2, OTC, ALDH4A1, GOT2, ALDH2, MAOA, GLUL, SAT1, PRODH, PRODH2, ALDH3A2",0.408935392973501,0.135488918941608,FALSE +"HCC95","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.31875,0.941,0.462,622,0.777,"ITGB4, GJA1, ITGA2, ITGA6, ITGA5, ITGA3, CDH2, ITGB8",0.335358024443874,0.109578981199086,FALSE +"HCC95","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.69405,-2.08,0.00741,8524,0.203,"ALDH9A1, ALDH7A1",2.13018179202067,0.692503962086787,TRUE +"HCC95","Input","KEGG_AXON_GUIDANCE",0.36922,1.08,0.349,1256,0.69,"EFNA5, EFNB1, UNC5B, SEMA4D, SEMA4B, SEMA5B, PLXNB2, EFNB2, EPHA2, ROBO2, RAC2, NTN4, EFNB3, PLXNA2, EPHB3, KRAS, NRAS, RAC3, SEMA3C, NCK1, HRAS, MET, EPHA6, SLIT1, SLIT3, NTN1",0.45717457304082,0.161150909262745,FALSE +"HCC95","Input","KEGG_BASAL_CELL_CARCINOMA",0.50903,1.5,0.0707,1596,0.339,"FZD1, WNT5A, FZD6, FZD2, DVL3, TP53",1.1505805862031,0.469800301796918,FALSE +"HCC95","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.50586,1.5,0.0938,2318,0.339,"TAF7, TAF1, GTF2A2, TAF2, GTF2F2, GTF2B, GTF2H1, GTF2H4, GTF2H3, TAF9, TAF6, TBPL1",1.02779716162094,0.469800301796918,FALSE +"HCC95","Input","KEGG_BASE_EXCISION_REPAIR",0.51717,1.54,0.0795,3256,0.369,"POLB, PARP2, POLD3, APEX1, POLD4, POLE, POLD1, LIG3, TDG, POLE4, POLD2, HMGB1, PARP1, XRCC1, POLE3, FEN1, MPG, MBD4, PCNA",1.09963287134353,0.43297363384094,FALSE +"HCC95","Input","KEGG_BETA_ALANINE_METABOLISM",-0.6157,-1.84,0.019,8121,0.225,"SRM, SMS, ALDH9A1, ALDH7A1",1.72124639904717,0.647817481888638,TRUE +"HCC95","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.54086,-1.61,0.0384,7833,0.27,"ACOT7, ACOT2, PECR, ACOX3, YOD1, ACAA1, ACOT1, ACOT4",1.41566877563247,0.568636235841013,FALSE +"HCC95","Input","KEGG_BLADDER_CANCER",0.43275,1.27,0.197,1129,0.591,"EGFR, KRAS, NRAS, THBS1, RPS6KA5, RB1, HRAS, MYC",0.705533773838407,0.228412519118745,FALSE +"HCC95","Input","KEGG_BUTANOATE_METABOLISM",-0.33985,-0.993,0.429,7232,0.798,"AACS, PDHA1, PDHB, BDH2, ACAT1, ALDH9A1, ALDH7A1",0.367542707815276,0.0979971086492706,FALSE +"HCC95","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.25152,-0.729,0.832,6772,0.926,"NFKBIB, GSK3B, AKT2, NFAT5, AKT3, CD81, PPP3CC, MAPK1, PIK3AP1, MAPK3, SOS1, AKT1, INPP5D, PIK3CB, PPP3R1, PPP3R2, PRKCB, NFATC2",0.0798766737092761,0.0333890133180656,FALSE +"HCC95","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.29773,-0.875,0.606,8274,0.856,"MYLK, CALM2, PPP3R1, ERBB3, PPP3R2, PRKACB, PRKCB, SPHK2, CACNA1A, BST1, PDE1C",0.217527375833714,0.0675262353228468,FALSE +"HCC95","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.27473,-0.808,0.693,6417,0.883,"COX7A2, COX4I1, CACNB2, UQCRQ, TPM4, TPM1, SLC8A1, COX5A, COX6C, MYL3, SLC9A6, CACNA2D1, COX7C, TPM3, TPM2, COX7B",0.159266765388193,0.0540392964224314,FALSE +"HCC95","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.50287,1.48,0.0884,444,0.347,"NECTIN1, CLDN11, SDC1, JAM3, CDH4, CNTN1, CLDN6, CD40, ITGA6, CD274, CLDN1, CNTNAP1, CDH2, ALCAM, CDH15, CDH3",1.05354773498693,0.459670525209126,FALSE +"HCC95","Input","KEGG_CELL_CYCLE",0.2799,0.839,0.648,2343,0.8,"TGFB2, CDC23, SMAD3, ANAPC4, CDC16, ANAPC7, ANAPC5, RBL1, CDC26, RB1, ORC3, CDC27, MYC, SFN, TFDP2, CDKN1B, CDK7, ANAPC1, ATM, SMC1B, TP53, BUB3, CCNB1, BUB1B, ORC4, MAD1L1, YWHAG, MCM5, MCM4, MCM3, RAD21, RBX1, CUL1, PRKDC, FZR1, SMC3, MCM6",0.188424994129407,0.0969100130080564,FALSE +"HCC95","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.22284,-0.659,0.913,6849,0.995,"GSK3B, AKT2, GNB1, GSK3A, CXCL14, AKT3, ROCK1, ROCK2, RAP1A, MAPK1, PRKACA, GRK2, CCL13, GNG7, RAP1B, MAPK3, ARRB2, ADCY5, SOS1, AKT1, STAT2, CCL15, TIAM1, CSK, PIK3CB, PRKACB, ARRB1, ADCY6, PRKCB",0.039529222465701,0.00217691925427455,FALSE +"HCC95","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.19649,0.585,0.968,1405,0.976,"IKBKB, TGFB2, SMAD3, KRAS, NRAS, RB1, HRAS, BAD, GAB2, MYC, BCL2L1, CDKN1B",0.0141246426916063,0.0105501823333082,FALSE +"HCC95","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.20983,-0.614,0.95,5925,1,"ACO1, DLD, IDH1, IDH3G, MDH1, CS, SUCLG1, PDHA1, PDHB, SUCLG2, IDH2",0.0222763947111523,0,FALSE +"HCC95","Input","KEGG_COLORECTAL_CANCER",-0.20102,-0.581,0.965,6480,0.987,"CCND1, PIK3R1, BAX, CTNNB1, GSK3B, AKT2, CASP3, APPL1, AKT3, MAPK1, MAPK3, AKT1, TGFB3, PIK3CB, CYCS, SMAD2",0.0154726866562074,0.00568284733036327,FALSE +"HCC95","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.56546,1.68,0.0307,795,0.295,"C9, PLAU, PLAT, F3, C3, VWF, CFH, MBL2",1.51286162452281,0.530177984021837,FALSE +"HCC95","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.29591,-0.893,0.564,7600,0.83,"DNMT1, MTR, LDHA, SRM, SMS, ADI1, AMD1",0.248720896016658,0.0809219076239261,FALSE +"HCC95","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.55509,1.66,0.0421,611,0.292,"EGFR, NGFR, IFNGR1, IL1RAP, CD40, IL1R2, LTBR, ACVR1, TGFB2, IL18, PLEKHO2, CXCL6",1.37571790416433,0.534617148551582,FALSE +"HCC95","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.35365,1.03,0.402,905,0.762,"ZBP1, CASP1, IKBKB, IL18, MAVS",0.39577394691553,0.1180450286604,FALSE +"HCC95","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.3576,-1.04,0.362,7283,0.811,"SGCD, DMD, PRKACA, MYL3, ITGB1, ACTG1, ADCY5, CACNA2D1, TPM3, TGFB3, TPM2, ITGA1, ITGA7, PRKACB, ADCY6, ITGA4, ITGB5, DES, ITGB3",0.441291429466834,0.090979145788844,FALSE +"HCC95","Input","KEGG_DNA_REPLICATION",0.42673,1.22,0.215,2505,0.622,"RFC2, SSBP1, POLD3, RFC4, RFC5, POLD4, RNASEH2A, POLE, POLD1, RPA3, MCM5, RPA2, MCM4, MCM3, POLE4, POLD2, MCM6, RPA1",0.667561540084395,0.206209615309181,FALSE +"HCC95","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.38939,1.16,0.231,1183,0.658,"EGFR, KRAS, ETV6",0.636388020107856,0.181774106386044,FALSE +"HCC95","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.59062,1.72,0.0324,162,0.302,"ADH4, ADH7, ALDH3A1, GSTM3",1.48945498979339,0.519993057042849,FALSE +"HCC95","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.34528,1.01,0.388,2331,0.721,"CES1, CES2, GMPS, TPMT, IMPDH1, NAT2, NAT1, XDH, IMPDH2, HPRT1, UCKL1, GUSB",0.411168274405793,0.142064735280571,FALSE +"HCC95","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.40015,1.18,0.228,741,0.658,"CD44, SDC1, ITGB4, LAMA1, ITGA2, ITGA6, LAMB3, TNC, ITGA5, ITGA3, LAMC2, VWF, ITGB8, LAMA5, THBS1",0.642065152999546,0.181774106386044,FALSE +"HCC95","Input","KEGG_ENDOCYTOSIS",-0.2701,-0.786,0.724,7143,0.891,"RABEP1, SH3GLB1, DNM1L, ASAP1, CBLB, VPS4A, EHD1, NEDD4L, CHMP2B, GRK2, PLD1, STAM, VPS37A, DNM2, MVB12B, PIP4K2B, RAB5B, SMAP2, ARRB2, SH3GL1, RAB5A, HSPA1L, RAB11B, ASAP2, RAB11FIP5, HSPA2, IQSEC1, PARD6B, ACAP1, DAB2, ERBB3, WWP1, PARD6G, ITCH, ARRB1, DNAJC6, SH3KBP1",0.140261433802853,0.0501222959631252,FALSE +"HCC95","Input","KEGG_ENDOMETRIAL_CANCER",0.27796,0.814,0.666,1596,0.801,"EGFR, KRAS, NRAS, HRAS, BAD, MYC, MLH1, FOXO3, TP53",0.176525770829699,0.0963674839157623,FALSE +"HCC95","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.39358,1.14,0.262,1106,0.623,"EGFR, PTPRZ1, JAM3, IKBKB, LYN, ADAM17, JUN, MAPK12, SRC, F11R, MET",0.581698708680255,0.20551195334083,FALSE +"HCC95","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.2687,0.809,0.693,1129,0.799,"NRG1, EGFR, JUN, KRAS, NRAS, NCK1, SRC, HRAS, BAD, MYC",0.159266765388193,0.0974532206860086,FALSE +"HCC95","Input","KEGG_ETHER_LIPID_METABOLISM",-0.4131,-1.21,0.215,7460,0.703,"PLD1, AGPS, PAFAH1B3, PAFAH2, PLA2G12A",0.667561540084395,0.153044674980176,FALSE +"HCC95","Input","KEGG_FATTY_ACID_METABOLISM",0.32621,0.954,0.477,4,0.763,"ADH4, ADH7",0.321481620959886,0.11747546204512,FALSE +"HCC95","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.22993,-0.672,0.887,6376,0.99,"VAV2, MAP2K2, PIK3R1, MAP2K3, MAP2K4, AKT2, AKT3, PRKCE, MAPK14, MAPK1, PRKCA, PLCG1, MAPK3, SOS1, MAP2K7, AKT1, INPP5D, PIK3CB, PLA2G12A, PRKCB",0.0520763801682736,0.00436480540245009,FALSE +"HCC95","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.45128,-1.33,0.142,7113,0.568,"ARPC3, AKT3, DNM1L, PRKCE, ASAP1, MAPK1, PRKCA, PLD1, WASF2, DNM2, PIP4K2B, PLCG1, MAPK3, GSN, AKT1, MARCKS, PRKCG, VASP, INPP5D, ASAP2, PIK3CB, SCIN, PRKCB, SPHK2, CFL2, PTPRC, AMPH, MARCKSL1",0.847711655616944,0.245651664288981,FALSE +"HCC95","Input","KEGG_FOCAL_ADHESION",0.30851,0.904,0.532,823,0.798,"EGFR, CAV1, CAV2, ITGB4, LAMA1, ITGA2, ITGA6, LAMB3, VAV1, TNC, ITGA5, ITGA3, IGF1R, LAMC2, RAC2, VWF, JUN, ITGB8, LAMA5, RAC3, THBS1, SRC",0.274088367704952,0.0979971086492706,FALSE +"HCC95","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.6915,-2.04,0.00938,6964,0.189,"GGH, PTS, ALPI, ALPP, ALPL",2.02779716162094,0.723538195826756,TRUE +"HCC95","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.31105,0.916,0.534,267,0.802,"AKR1B10, ALDOC, AKR1B1",0.272458742971444,0.0958256317158365,FALSE +"HCC95","Input","KEGG_GALACTOSE_METABOLISM",-0.3265,-0.956,0.472,6547,0.821,"HK2, GALE, GLB1, UGP2, GALK1, PFKL, GALK2, PFKP, GALT, GCK, PGM1",0.326058001365912,0.0856568428805592,FALSE +"HCC95","Input","KEGG_GAP_JUNCTION",0.24179,0.72,0.813,1246,0.885,"EGFR, GJA1, KRAS, NRAS, SRC, PLCB4, ADCY3, ADCY8, HRAS, MAP3K2, TUBA4A",0.0899094544059319,0.0530567293021746,FALSE +"HCC95","Input","KEGG_GLIOMA",-0.26594,-0.78,0.718,7341,0.879,"MAPK1, PRKCA, PLCG1, MAPK3, SOS1, AKT1, PRKCG, CDK6, PIK3CB, CALM2, PRKCB, CDKN2A",0.1438755557577,0.0560111249262281,FALSE +"HCC95","Input","KEGG_GLUTATHIONE_METABOLISM",0.34949,1.02,0.374,897,0.732,"GCLC, GCLM, GSTM3, ODC1, PGD, GPX2, GSS, GSTP1, GSR, G6PD",0.42712839779952,0.135488918941608,FALSE +"HCC95","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.54756,-1.61,0.0575,8387,0.27,"CEL, GK, ALDH9A1, ALDH7A1, MGLL",1.24033215531037,0.568636235841013,FALSE +"HCC95","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33046,0.974,0.439,1358,0.751,"LPCAT3, PCYT1B, PCYT1A, PLPP1, DGKA, LCLAT1, DGKZ, LPCAT2, CDIPT, PISD",0.357535479757879,0.124360062995832,FALSE +"HCC95","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.40043,1.16,0.272,1202,0.658,"PIPOX, GATM, PHGDH, PSAT1, MAOA, PSPH",0.565431095965801,0.181774106386044,FALSE +"HCC95","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.36729,1.09,0.326,175,0.706,"ADH4, ADH7, ALDH3A1, ALDOC",0.486782399932061,0.151195298948196,FALSE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.41301,1.19,0.24,1065,0.66,"XYLT2, CHST14, B4GALT7",0.619788758288394,0.180456064458131,FALSE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.57653,1.72,0.0309,1478,0.302,"HS6ST2, XYLT2, B4GALT7, EXTL2",1.51004152057517,0.519993057042849,FALSE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.55906,-1.64,0.0441,6606,0.288,"FUT8, B4GALT3, B4GAT1, B4GALT4, ST3GAL2",1.35556141053216,0.540607512240769,FALSE +"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.27533,0.821,0.653,3109,0.811,"IDS, HPSE, HEXB, ARSB, GUSB, SGSH, HEXA",0.185086818724926,0.090979145788844,FALSE +"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.26283,-0.769,0.746,8275,0.878,"ST3GAL2",0.127261172527331,0.0565054840938974,FALSE +"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.41618,1.27,0.172,1786,0.591,"GLA, FUT1, HEXB",0.764471553092451,0.228412519118745,FALSE +"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.59234,-1.74,0.0364,8249,0.259,"B4GALT4, GCNT2, ST3GAL6, ST3GAL4, B3GNT3",1.43889861635094,0.586700235918748,FALSE +"HCC95","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.29889,0.877,0.586,6214,0.842,"PIGB, PIGS, PIGX, PGAP1, PIGU, PIGT, PIGO, PIGG, GPAA1, PIGK, PIGW, PIGA",0.232102383981909,0.0746879085003505,FALSE +"HCC95","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.55036,-1.62,0.0549,6527,0.292,"MDH1, CS, PGP, HYI",1.26042765554991,0.534617148551582,FALSE +"HCC95","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.27382,0.802,0.674,1177,0.79,"EGFR, MMP14, JUN, MAPK12, KRAS, NRAS, SRC, PLCB4, ADCY3, ADCY8, ATF4, HRAS, MAP3K2, CALML3",0.17134010346468,0.102372908709559,FALSE +"HCC95","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.29688,-0.867,0.569,6745,0.861,"WNT11, GSK3B, PRKACA, CSNK1G2, SHH, CSNK1D, PRKACB",0.244887733604929,0.0649968485463452,FALSE +"HCC95","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.52269,1.55,0.0887,442,0.379,"CD44, ITGA2, ITGA6, IL1R2, ITGA5, ITGA3, CD9",1.05207638016827,0.421360790031928,FALSE +"HCC95","Input","KEGG_HISTIDINE_METABOLISM",-0.34838,-1.02,0.39,8524,0.786,"ALDH9A1, ALDH7A1",0.408935392973501,0.104577453960592,FALSE +"HCC95","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.62976,1.83,0.0197,2505,0.239,"TOP3B, RAD54L, SSBP1, POLD3, BLM, POLD4, POLD1, RPA3, RPA2, MUS81, RAD51, POLD2, RPA1",1.70553377383841,0.621602099051862,TRUE +"HCC95","Input","KEGG_HUNTINGTONS_DISEASE",-0.21332,-0.62,0.928,5918,1,"NDUFB1, AP2A2, SLC25A31, NDUFA8, DCTN4, NDUFB8, DCTN1, COX5B, NDUFS7, CLTB, CREB5, CLTA, COX7A2, COX4I1, NDUFS2, UQCRQ, HTT, POLR2H, DCTN2, NDUFA3, BAX, SLC25A6, NDUFAB1, CASP3, TBP, GPX1, COX5A, NDUFB4, HDAC2, NDUFB7, COX6C, NDUFA2, COX7C, SLC25A4, CYCS, COX7B, TGM2, ATP5MC2",0.0324520237811379,0,FALSE +"HCC95","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.34948,-1.04,0.389,7768,0.811,"ITGB1, ACTG1, CACNA2D1, TPM3, TGFB3, TPM2, ITGA1, ITGA7, ITGA4, ITGB5, DES, ITGB3, ACE",0.410050398674292,0.090979145788844,FALSE +"HCC95","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.42159,-1.22,0.206,6918,0.705,"PIP4K2C, PI4KA, INPP1, OCRL, INPPL1, PIP4K2A, PIP4K2B, PLCG1, PIK3C2B, ITPKB, SYNJ1, INPP4B, PIK3CB, PI4KB",0.686132779630847,0.151810883008601,FALSE +"HCC95","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.18628,-0.55,0.988,6195,0.981,"PYGB, MAP2K1, RPS6KB1, EIF4E, RPS6, MAP2K2, PRKAR1A, PIK3R1, HK2, RHEB, PPP1R3D, TRIP10, GSK3B, AKT2, AKT3, FBP1, CBLB, MAPK1, PRKACA, GYS1, PRKAR2B, MAPK3, SOS1, AKT1, INPP5D, SORBS1, PIK3CB, CALM2, PDE3A, GCK, PRKACB",0.00524305541237188,0.0083309926200515,FALSE +"HCC95","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.26382,-0.76,0.78,6243,0.883,"STAT1, OSM, PTPN11, EPO, CCND1, PIK3R1, STAT5B, PIM1, STAM2, SPRY2, AKT2, IL13RA2, AKT3, CBLB, STAM, SOS1, AKT1, STAT2, PIK3CB, SPRY1, SPRY4",0.10790539730952,0.0540392964224314,FALSE +"HCC95","Input","KEGG_LEISHMANIA_INFECTION",-0.33228,-0.962,0.478,7269,0.822,"MAPK14, IRAK4, MAPK1, ITGB2, MAPK3, ITGB1, MYD88, TGFB3, PRKCB, ITGA4, CYBA, MARCKSL1",0.320572103387881,0.0851281824599496,FALSE +"HCC95","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.3173,0.961,0.445,966,0.764,"THY1, CLDN11, JAM3, CLDN6, CLDN1, VAV1, RAC2, MAPK12, CTNND1, F11R, OCLN",0.351639989019068,0.11690664142431,FALSE +"HCC95","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.74901,-2.14,0.00385,8438,0.218,"YOD1, ALDH9A1, ALDH7A1",2.4145392704915,0.661543506395395,TRUE +"HCC95","Input","KEGG_LONG_TERM_DEPRESSION",-0.28569,-0.838,0.645,7341,0.845,"MAPK1, PRKCA, PRKG1, MAPK3, PPP2CB, PRKCG, PLA2G12A, PRKCB, CACNA1A",0.190440285364732,0.0731432910503077,FALSE +"HCC95","Input","KEGG_LONG_TERM_POTENTIATION",-0.31122,-0.905,0.528,7247,0.818,"RAP1A, PPP3CC, MAPK1, PRKACA, PRKCA, RAP1B, MAPK3, PRKCG, CALM2, PPP3R1, RPS6KA3, PPP3R2, PRKACB, PRKCB",0.277366077466188,0.087246696328677,FALSE +"HCC95","Input","KEGG_LYSINE_DEGRADATION",-0.35242,-1.03,0.39,7895,0.817,"ACAT1, DOT1L, GCDH, ALDH9A1, ALDH7A1",0.408935392973501,0.0877779434675845,FALSE +"HCC95","Input","KEGG_LYSOSOME",-0.33836,-0.998,0.427,6094,0.804,"GGA2, SLC11A2, AP1G1, NAGPA, PLA2G15, AP3M1, PSAPL1, AP3M2, CLTB, CLTA, ARSA, ATP6AP1, FUCA1, GLB1, AP1B1, SMPD1, DNASE2, CTSC, CTSF, CLN3, AP3S1, ACP5, AP1M2, ATP6V0A2, LGMN, GGA3, AP3D1, AGA, ATP6V1H, ATP6V0A1, TCIRG1, CTSK, CTSO, AP3S2, PPT2, IGF2R, SCARB2, NAPSA, GNS, GGA1, ASAH1, MANBA, ATP6V0D1, LIPA, AP1S2, SORT1, CD63, SLC17A5, MCOLN1",0.369572124974976,0.0947439512515487,FALSE +"HCC95","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.21082,-0.61,0.944,7247,1,"RAP1A, PPP3CC, MAPK14, MAPK1, PRKACA, PRKCA, PPP5C, CD14, RAP1B, MAPK3, ARRB2, CACNA2D1, SOS1, MAP2K7, AKT1, PRKCG, RASA2, MOS, HSPA1L, MAPKAPK2, TGFB3, MAP3K5, HSPA2, PPP3R1, MAP4K4, RPS6KA3, PPP3R2, PLA2G12A, STMN1, PRKACB, ARRB1, PRKCB, NFATC2, CACNA1A",0.025028005701931,0,FALSE +"HCC95","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.60038,-1.78,0.0227,8205,0.24,"FOXA2, GCK, HNF1A, HNF4A",1.64397414280688,0.619788758288394,TRUE +"HCC95","Input","KEGG_MELANOGENESIS",-0.29709,-0.863,0.619,7341,0.856,"MAPK1, PRKACA, PRKCA, MAPK3, ADCY5, PRKCG, TYR, CALM2, PRKACB, TYRP1, DCT, ADCY6, PRKCB, MITF",0.208309350979882,0.0675262353228468,FALSE +"HCC95","Input","KEGG_MELANOMA",0.34645,1.02,0.371,1106,0.732,"EGFR, IGF1R, FGF13, FGF2, KRAS, NRAS, RB1, HRAS, BAD, MET",0.430626090384954,0.135488918941608,FALSE +"HCC95","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.73845,2.19,0,162,0.139,"ADH4, ADH7, AKR1C2, AKR1C1, AKR1C3, CYP2S1, ALDH3A1, GSTM3",Inf,0.856985199745905,TRUE +"HCC95","Input","KEGG_MISMATCH_REPAIR",0.64059,1.91,0.0207,2505,0.265,"MSH3, RFC2, SSBP1, POLD3, MLH1, RFC4, RFC5, POLD4, MSH2, PMS2, POLD1, RPA3, RPA2, POLD2, MSH6, RPA1",1.68402965454308,0.576754126063192,FALSE +"HCC95","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.44542,-1.26,0.197,6130,0.641,"RPS6KA2, RPS6KB1, EIF4E, RPS6, PIK3R1, RHEB, RPS6KA6, AKT2, AKT3, MAPK1, MAPK3, AKT1, PIK3CB, RPS6KA3, ULK3",0.705533773838407,0.193141970481183,FALSE +"HCC95","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.29347,0.864,0.608,873,0.813,"IFNGR1, MICA, VAV1, RAET1L, ULBP2, PTPN6, RAC2, KRAS, NRAS, RAC3, LAT, TNFRSF10A",0.216096420727265,0.0899094544059319,FALSE +"HCC95","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.40838,1.22,0.216,2491,0.622,"GRIN1, NR3C1, PRSS3, F2RL1, HRH1, P2RX4, LTB4R2, CGA, CTSG, F2",0.665546248849069,0.206209615309181,FALSE +"HCC95","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.20035,-0.579,0.956,6414,0.978,"PTPN11, MAP2K2, PIK3R1, FRS2, RPS6KA6, CAMK2D, BAX, NFKBIB, YWHAQ, GSK3B, AKT2, AKT3, RIPK2, ARHGDIA, RAP1A, MAPK14, IRAK4, ARHGDIB, MAPK1, PLCG1, RAP1B, MAPK3, SOS1, MAP2K7, AKT1, CSK, MAPKAPK2, MAP3K5, PIK3CB, CALM2, RPS6KA3, SORT1, MAGED1, PSEN1",0.0195421077238999,0.00966114521239857,FALSE +"HCC95","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.62232,-1.85,0.0192,8340,0.244,"ENPP1, NT5E, NNMT, NNT, QPRT, BST1",1.71669877129645,0.612610173661271,TRUE +"HCC95","Input","KEGG_NITROGEN_METABOLISM",-0.67522,-1.93,0.0152,7877,0.268,"CPS1, CA2, GLS, GLS2, CA14, CA8, GLUD2",1.81815641205523,0.571865205971211,FALSE +"HCC95","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.38109,1.14,0.268,684,0.623,"TRAF6, CASP1, IKBKB, IL18, TRIP6, MAPK12",0.571865205971211,0.20551195334083,FALSE +"HCC95","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.50282,1.5,0.0752,3006,0.339,"XRCC4, POLM, PRKDC, XRCC5, LIG4, FEN1",1.12378215940836,0.469800301796918,FALSE +"HCC95","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.31675,-0.92,0.53,7718,0.827,"PLCG1, MAPK3, SOS1, AKT1, PRKCG, CDK6, PIK3CB, PRKCB, CDKN2A, RASSF5, FHIT",0.275724130399211,0.0824944904474534,FALSE +"HCC95","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.2818,-0.83,0.645,6983,0.85,"APH1A, NCSTN, LFNG, HDAC2, CIR1, DTX3L, NOTCH2, CTBP2, PSEN2, PSEN1",0.190440285364732,0.0705810742857073,FALSE +"HCC95","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.58293,1.71,0.0438,2715,0.286,"XPA, DDB2, ERCC5, ERCC8, RAD23B, RFC2, POLD3, RFC4, CUL4A, RFC5, ERCC1, CDK7, GTF2H1, MNAT1, POLD4, POLE, GTF2H4, ERCC4, ERCC3, POLD1, RPA3, GTF2H3, RPA2, GTF2H5, DDB1, POLE4, RBX1, POLD2, XPC, CCNH, RPA1, ERCC2, GTF2H2",1.3585258894959,0.543633966870957,FALSE +"HCC95","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.29047,0.871,0.574,1414,0.826,"ALG13, ALG12, ST6GAL1, MAN2A1, ALG2, MGAT1, MGAT4B, B4GALT1, MAN1A1",0.241088107602027,0.0830199526796178,FALSE +"HCC95","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.58963,-1.7,0.0386,7045,0.262,"PDC, PRKACA, PRKG1, ARRB2, CALM2, PRKACB, PDE1C",1.41341269532825,0.581698708680255,FALSE +"HCC95","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.38196,-1.12,0.284,6210,0.705,"ATIC, MTHFS, GART, MTHFR, MTR, TYMS",0.546681659952962,0.151810883008601,FALSE +"HCC95","Input","KEGG_OOCYTE_MEIOSIS",-0.19859,-0.581,0.969,6621,0.987,"CCNB2, PPP2R5B, RPS6KA6, CAMK2D, YWHAQ, MAD2L1, PPP2R5A, PLK1, PPP3CC, MAPK1, PRKACA, MAPK3, PPP2CB, ADCY5, MOS, SGO1, CALM2, PPP3R1, CDK2, RPS6KA3, PPP3R2, PRKACB, ADCY6",0.0136762229492347,0.00568284733036327,FALSE +"HCC95","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.20024,-0.582,0.967,6439,1,"FUCA1, GLB1, FUCA2, AGA, MANBA",0.0145735259169983,0,FALSE +"HCC95","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.43404,-1.3,0.169,6417,0.582,"COX7A2, ATP6AP1, COX4I1, NDUFS2, UQCRQ, NDUFA3, NDUFAB1, ATP6V1B1, PPA1, COX5A, ATP6V0A2, NDUFB4, ATP6V1F, ATP6V1H, PPA2, NDUFB7, ATP6V1B2, ATP6V1A, ATP6V1C2, COX6C, ATP6V0A1, TCIRG1, NDUFA2, ATP6V1C1, ATP6V1D, ATP6V1E1, COX7C, ATP6V1G1, ATP6V0D1, COX7B, ATP5MC2, COX17",0.772113295386326,0.235077015350112,FALSE +"HCC95","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.46048,-1.35,0.134,7735,0.554,"GALNT6, B4GALT5, ST3GAL2, C1GALT1C1, C1GALT1, GALNT16, GALNT17",0.872895201635192,0.25649023527157,FALSE +"HCC95","Input","KEGG_P53_SIGNALING_PATHWAY",-0.31951,-0.938,0.507,7931,0.847,"CD82, RCHY1, CDK6, CYCS, CDK2, COP1, RRM2, CDKN2A, TP53I3",0.294992040666664,0.0721165896692931,FALSE +"HCC95","Input","KEGG_PANCREATIC_CANCER",0.24554,0.717,0.808,1105,0.878,"EGFR, IKBKB, TGFB2, RAC2, SMAD3, KRAS, RAC3, RB1, BAD",0.0925886392254138,0.0565054840938974,FALSE +"HCC95","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.42371,1.25,0.195,320,0.608,"BCAT2, BCAT1",0.709965388637482,0.216096420727265,FALSE +"HCC95","Input","KEGG_PARKINSONS_DISEASE",-0.2927,-0.843,0.611,6229,0.872,"COX5B, NDUFS7, PARK7, COX7A2, COX4I1, NDUFS2, UQCRQ, NDUFA3, SLC25A6, UBE2G2, NDUFAB1, UBE2G1, UBE2L6, UBE2L3, CASP3, COX5A, NDUFB4, NDUFB7, COX6C, NDUFA2, UBA1, COX7C, UBE2J1, SLC25A4, CYCS, COX7B, SLC18A1, ATP5MC2",0.213958789757446,0.0594835150674328,FALSE +"HCC95","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.34548,-1.02,0.383,5571,0.786,"EZR, NCK2, FYN, ARPC4, TUBB1, ACTB, WASL, TUBA1B, ARPC5, TUBB3, NCL, TUBA1C, TUBB, TUBB2A, CTNNB1, YWHAQ, TUBA3C, ARPC3, ROCK1, ROCK2, ARHGEF2, TUBB6, PRKCA, HCLS1, CD14, ITGB1, ACTG1, TUBB2B",0.416801226031377,0.104577453960592,FALSE +"HCC95","Input","KEGG_PATHWAYS_IN_CANCER",0.29121,0.865,0.578,1460,0.825,"EGFR, SLC2A1, FZD1, TRAF6, LAMA1, WNT5A, RXRA, ITGA2, ITGA6, AR, LAMB3, PML, IKBKB, ITGA3, IGF1R, FZD6, LAMC2, TGFB2, RAC2, JUN, GSTP1, FGF13, FGF2, SMAD3, LAMA5, KRAS, NRAS, RAC3, RB1, RARA, HRAS, MSH3, BAD, MET, PTGS2, MYC, MLH1, FZD2, BCL2L1, DVL3, CDKN1B, FH, STAT3",0.238072161579471,0.0835460514500749,FALSE +"HCC95","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.30188,0.904,0.547,771,0.798,"AKR1B1, UGDH",0.262012673666569,0.0979971086492706,FALSE +"HCC95","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.26871,-0.78,0.733,7036,0.879,"RPE, FBP1, PFKL, DERA, PFKP, RBKS, RPIA, PGM1",0.134896025358872,0.0560111249262281,FALSE +"HCC95","Input","KEGG_PEROXISOME",-0.38494,-1.14,0.267,7196,0.721,"PEX26, PEX11A, ECI2, AMACR, ABCD4, PEX16, AGPS, ABCD3, HSD17B4, ACSL6, PEX6, SCP2, PEX12, PEX1, ABCD1, DECR2, PECR, IDH2, PEX19, ACOX3, ACOT8, ACAA1, ACSL1, HACL1, ACSL5, FAR2",0.573488738635425,0.142064735280571,FALSE +"HCC95","Input","KEGG_PHENYLALANINE_METABOLISM",0.64089,1.89,0.0277,1060,0.244,"ALDH3A1, GOT2, MAOA",1.55752023093555,0.612610173661271,TRUE +"HCC95","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.41044,-1.19,0.24,6918,0.656,"PIP4K2C, PI4KA, INPP1, PRKCA, OCRL, INPPL1, PIP4K2A, PIP4K2B, PLCG1, PIK3C2B, ITPKB, PRKCG, SYNJ1, INPP4B, INPP5D, PIK3CB, CALM2, PI4KB, PRKCB",0.619788758288394,0.18309616062434,FALSE +"HCC95","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.3439,-0.998,0.434,7114,0.804,"EARS2, UROD, CPOX, PPOX, HMOX1, HCCS, UROS",0.362510270487489,0.0947439512515487,FALSE +"HCC95","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.37255,-1.09,0.309,7286,0.752,"ACADM, GK2, SLC27A4, FABP6, FABP5, ILK, DBI, ACSL6, FABP3, SCP2, SORBS1, FABP4, ACOX3, GK, ACAA1, ACSL1, CYP27A1, ACSL5",0.510041520575165,0.123782159408358,FALSE +"HCC95","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.46461,1.4,0.103,37,0.438,"AKR1D1",0.987162775294828,0.3585258894959,FALSE +"HCC95","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.31845,0.934,0.512,1341,0.777,"CD40, TAP1, TAP2",0.290730039024169,0.109578981199086,FALSE +"HCC95","Input","KEGG_PRION_DISEASES",0.33232,0.976,0.442,563,0.762,"C9, PRNP",0.354577730650908,0.1180450286604,FALSE +"HCC95","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.21599,-0.627,0.937,6530,1,"PIK3R1, CCNB2, RPS6KA6, AKT2, MAD2L1, PLK1, AKT3, MAPK14, MAPK1, PRKACA, MAPK3, ADCY5, AKT1, MOS, PIK3CB, CDK2, PDE3A, RPS6KA3, PRKACB, ADCY6",0.0282604091122217,0,FALSE +"HCC95","Input","KEGG_PROPANOATE_METABOLISM",-0.46237,-1.31,0.181,7870,0.585,"LDHA, ACAT1, SUCLG2, ACSS3, ALDH9A1, ALDH7A1",0.742321425130815,0.23284413391782,FALSE +"HCC95","Input","KEGG_PROSTATE_CANCER",0.37258,1.08,0.312,1105,0.69,"EGFR, AR, IKBKB, IGF1R, GSTP1, KRAS, NRAS, RB1, ATF4, HRAS, BAD",0.505845405981557,0.161150909262745,FALSE +"HCC95","Input","KEGG_PROTEASOME",0.52184,1.53,0.0689,3172,0.359,"PSMB9, PSMB8, PSMB10, PSME1, PSMB4, PSME2, PSME4, POMP, PSMB3, PSMB7, PSMA4, PSME3, PSMA8, PSMC2, PSMA2, PSMF1, PSMB2, PSMA6, PSMB5, PSMA1, PSMD12, PSMD4, PSMC4, PSMA7, PSMB1, PSMC3, PSMC5, PSMC1",1.16178077809237,0.444905551421681,FALSE +"HCC95","Input","KEGG_PROTEIN_EXPORT",-0.28253,-0.842,0.622,7078,0.849,"SPCS2, SEC11A, IMMP1L, SEC11C",0.206209615309181,0.0710923097560473,FALSE +"HCC95","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.39349,-1.17,0.231,7991,0.677,"CA2, GLS, GLS2, GLUD2",0.636388020107856,0.169411331314856,FALSE +"HCC95","Input","KEGG_PURINE_METABOLISM",-0.36054,-1.08,0.308,7213,0.756,"AK2, AMPD2, APRT, NPR1, POLA2, GDA, PDE4D, POLA1, ADCY5, GMPR, PRUNE1, AK1, ENPP1, PDE3A, NPR2, PAPSS2, RRM2, NT5E, ADCY6, NME4, FHIT, PDE4A, PDE1C",0.511449283499556,0.121478204498793,FALSE +"HCC95","Input","KEGG_PYRIMIDINE_METABOLISM",-0.27985,-0.802,0.69,7477,0.883,"POLA2, TYMP, CMPK1, CTPS1, UMPS, POLA1, TYMS, CTPS2, RRM2, NT5E, NME4, TK1, TK2",0.161150909262745,0.0540392964224314,FALSE +"HCC95","Input","KEGG_PYRUVATE_METABOLISM",-0.40539,-1.19,0.238,7239,0.656,"PDHA1, ACYP2, PDHB, HAGH, LDHA, ACAT1, ME3, ACYP1, ALDH9A1, ALDH7A1",0.623423042943488,0.18309616062434,FALSE +"HCC95","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.23428,0.692,0.843,733,0.904,"EGFR, ITGB4, PFN2, ITGA2, IQGAP2, ITGA6, VAV1, ITGA5, ITGA3, RAC2, GNA13, ITGB8, FGF13, FGF2, KRAS, NRAS, RAC3",0.0741724253752577,0.0438315695246367,FALSE +"HCC95","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.62807,-1.82,0.0378,6893,0.22,"ATG4C, ATG4A, GABARAPL1, ATG4B, ATG3, ULK3, GABARAPL2",1.42250820016277,0.657577319177794,TRUE +"HCC95","Input","KEGG_RENAL_CELL_CARCINOMA",0.20618,0.614,0.944,1106,0.967,"SLC2A1, TGFB2, JUN, KRAS, NRAS, HRAS, MET",0.025028005701931,0.0145735259169983,FALSE +"HCC95","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.55799,-1.64,0.0375,7272,0.288,"MME, ANPEP, CPA3, ACE",1.42596873227228,0.540607512240769,FALSE +"HCC95","Input","KEGG_RETINOL_METABOLISM",0.71108,2.08,0.00416,314,0.178,"ADH4, ADH7, DHRS3",2.38090666937326,0.749579997691106,TRUE +"HCC95","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.65588,-1.88,0.018,6852,0.28,"ACP1, ACP5, PHPT1, TYR, MTMR6, ENPP1",1.74472749489669,0.552841968657781,FALSE +"HCC95","Input","KEGG_RIBOSOME",0.2264,0.66,0.902,3922,0.933,"RPL22L1, RPL37, RPL29, RPL26L1, RPL32, RPL4, RPS27A, RPL37A, RPL14, RPL27, RPL24, RSL24D1, RPSA, RPL34, RPS12, RPS16, RPL36A, RPL36AL, RPL35A, RPL27A, RPL7A, RPL35, RPL13A, RPS3A, RPL10A, FAU, RPS8, RPS11, RPS15A, UBA52, RPS3, RPL21, RPL19, RPL36, RPL23, RPL23A, RPLP0, RPS26, RPL30",0.0447934624580583,0.0301183562535,FALSE +"HCC95","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.27389,-0.79,0.723,5873,0.895,"ATG12, MAPK8, TKFC, TBK1, FADD, MAP3K7, PIN1, DHX58, NFKBIB, IRF3, CYLD, OTUD5, MAPK14, TRAF3, DDX58, ISG15, RIPK1, DDX3Y",0.140861702705469,0.048176964684088,FALSE +"HCC95","Input","KEGG_RNA_DEGRADATION",0.2515,0.754,0.745,3336,0.851,"PAPOLG, EXOSC1, LSM4, DIS3, EXOSC3, EXOSC8, EXOSC6, EXOSC9, PARN, EXOSC4, LSM6, EXOSC5, C1D, HSPA9, SKIV2L, PNPT1, CNOT6, XRN2, EXOSC2, LSM3, MTREX, EDC3, EXOSC7, LSM8, XRN1, ZCCHC7, LSM7, LSM2, TTC37",0.127843727251707,0.0700704399154121,FALSE +"HCC95","Input","KEGG_RNA_POLYMERASE",0.24366,0.725,0.834,6706,0.888,"POLR3G, POLR1E, POLR1B, POLR1A, POLR2G, POLR2K, POLR1C, POLR1D, POLR2J, POLR2L, POLR2E, POLR2I, POLR2A, POLR2D, POLR2C, POLR3C, POLR2B, POLR2F, POLR3H, POLR3F, POLR3K, POLR3A, POLR3D, POLR2H, POLR3B, POLR3GL",0.0788339493622613,0.051587034221399,FALSE +"HCC95","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.25909,0.764,0.734,1348,0.845,"BUD23, SCLY, MAT1A, METTL2B, MAT2B",0.134303940083929,0.0731432910503077,FALSE +"HCC95","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.30067,0.871,0.577,431,0.826,"TRAF6, LAMA1, RXRA, ITGA2, ITGA6, LAMB3, IKBKB, ITGA3, LAMC2",0.238824186844269,0.0830199526796178,FALSE +"HCC95","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.48851,-1.45,0.0839,6947,0.432,"STX18, STX6, VTI1B, VTI1A, SNAP47, SEC22B, SNAP29, VAMP7, VAMP4, STX12, YKT6, STX7, STX3",1.0762380391713,0.364516253185088,FALSE +"HCC95","Input","KEGG_SPHINGOLIPID_METABOLISM",0.33855,1.01,0.396,1337,0.721,"PLPP1, KDSR, GLA, GALC, NEU3, SGPL1, UGT8",0.402304814074488,0.142064735280571,FALSE +"HCC95","Input","KEGG_SPLICEOSOME",0.27153,0.806,0.711,3431,0.794,"DHX8, NCBP1, DHX38, CRNKL1, SLU7, LSM4, DDX42, EFTUD2, SNU13, HSPA1A, TXNL4A, LSM6, PRPF6, PRPF38A, PRPF19, AQR, SNRPB, HSPA6, PPIE, ZMAT2, BCAS2, PPIL1, DDX46, PRPF18, THOC3, ISY1, CCDC12, SF3A2, SNRPD3, EIF4A3, SNRPF, NCBP2, SNRNP200, LSM3, PRPF8, TCERG1, HNRNPK, SF3B5, PLRG1, DDX39B, USP39, SNRPG, SNRPD1, SNRPD2, PRPF40B, LSM8, SF3B6, SF3A1, SNW1, HNRNPA3, ALYREF, SNRNP70, DDX23, SMNDC1, THOC2, LSM7, LSM2, CDC5L, SF3B1, TRA2B, SF3A3, DDX5, SNRNP40, HNRNPC, SNRPC",0.148130399270234,0.100179497572904,FALSE +"HCC95","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.29046,-0.842,0.629,7465,0.849,"GYS1, GBE1, ENPP1, GCK, PGM1",0.201349354554731,0.0710923097560473,FALSE +"HCC95","Input","KEGG_STEROID_BIOSYNTHESIS",-0.38885,-1.13,0.285,7136,0.702,"HSD17B7, CYP51A1, SOAT1, TM7SF2, CEL, LIPA",0.54515513999149,0.153662887870195,FALSE +"HCC95","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.79115,2.32,0,37,0.111,"AKR1C2, AKR1C1, AKR1C3, AKR1D1",Inf,0.954677021213343,TRUE +"HCC95","Input","KEGG_SULFUR_METABOLISM",-0.75757,-2.24,0.00377,8250,0.229,"CHST11, PAPSS2, SULT1A3, SULT1A1",2.42365864979421,0.640164517660112,TRUE +"HCC95","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.68017,2.01,0.011,224,0.199,"C9, C3, CD40",1.95860731484178,0.701146923590293,TRUE +"HCC95","Input","KEGG_TASTE_TRANSDUCTION",-0.6437,-1.85,0.0264,8551,0.244,"PRKACB, ADCY6, CACNA1A",1.57839607313017,0.612610173661271,TRUE +"HCC95","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.54274,-1.59,0.0586,7115,0.276,"IDI1, HMGCR, MVD, FDPS, ACAT1",1.23210238398191,0.559090917934782,FALSE +"HCC95","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.30931,-0.91,0.536,7152,0.835,"ROCK1, ROCK2, SMAD5, MAPK1, MAPK3, PPP2CB, TGFB3, ZFYVE9, INHBE, SMAD2",0.27083521030723,0.0783135245163979,FALSE +"HCC95","Input","KEGG_THYROID_CANCER",0.28918,0.854,0.617,1129,0.807,"RXRA, KRAS, NRAS, HRAS, MYC",0.209714835966758,0.0931264652779296,FALSE +"HCC95","Input","KEGG_TIGHT_JUNCTION",0.28629,0.831,0.619,1088,0.804,"CLDN11, JAM3, MYH4, CLDN6, CLDN1, YES1, EPB41L1, YBX3, KRAS, NRAS, PATJ, SRC, F11R, OCLN, HRAS, ACTN4",0.208309350979882,0.0947439512515487,FALSE +"HCC95","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.29647,-0.861,0.607,6156,0.847,"TLR9, MAP2K1, STAT1, TBK1, FADD, MAP3K7, MAP2K2, PIK3R1, MAP2K3, MAP2K4, AKT2, IRF3, AKT3, MAPK14, IRAK4, MAPK1, TRAF3, TOLLIP, CD14, CTSK, MAPK3, MAP2K7, AKT1, MYD88, PIK3CB, RIPK1",0.216811308924742,0.0721165896692931,FALSE +"HCC95","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.38548,-1.13,0.274,7805,0.702,"KMO, ACAT1, GCDH, ALDH9A1, ALDH7A1",0.562249437179612,0.153662887870195,FALSE +"HCC95","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.28783,0.842,0.603,498,0.806,"PDX1, ABCC8, IKBKB, IRS1",0.219682687859849,0.0936649581949093,FALSE +"HCC95","Input","KEGG_TYROSINE_METABOLISM",0.54225,1.63,0.0553,1060,0.301,"ADH4, ADH7, ALDH3A1, BUD23, GOT2, METTL2B, MAOA",1.2572748686953,0.521433504406157,FALSE +"HCC95","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.26284,-0.779,0.741,6772,0.87,"NFKBIB, GSK3B, AKT2, NFAT5, AKT3, PPP3CC, MAPK14, CBLB, MAPK1, PLCG1, MAPK3, SOS1, MAP2K7, AKT1, PIK3CB, PPP3R1, PPP3R2, NFATC2, PTPRC, GRAP2",0.130181792020672,0.0604807473813815,FALSE +"HCC95","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.18932,0.555,0.975,1462,0.98,"TRAF6, PML, UBE2H, DDB2, CDC23, ANAPC4, CDC16, ANAPC7, FBXO4, NEDD4, ANAPC5, CDC26, ERCC8, CDC27, CUL4A, UBE2Z, FBXO2, UBE3C, FBXW11, ANAPC1",0.0109953843014632,0.00877392430750515,FALSE +"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.61955,1.86,0.0339,320,0.24,"BCAT2, BCAT1",1.46980030179692,0.619788758288394,TRUE +"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.31255,-0.927,0.499,7895,0.826,"ACAT1, ACAA2, HSD17B10, ALDH9A1, ACAA1, ALDH7A1",0.30189945437661,0.0830199526796178,FALSE +"HCC95","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.48012,-1.38,0.153,7096,0.522,"ARHGEF1, ROCK1, ROCK2, PRKCE, MAPK1, PRKACA, PRKCA, NPR1, PRKG1, MAPK3, ADCY5, PRKCG, PPP1R12B, ARHGEF11, KCNMA1, MYLK, CALM2, CALD1, NPR2, PLA2G12A, PRKACB, ADCY6, PRKCB",0.815308569182401,0.282329496997738,FALSE +"HCC95","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.40177,-1.2,0.231,5979,0.701,"RAB5C, DCTN4, DCTN1, NSF, CREB5, RAB11A, DCTN2, ARHGDIA, ARHGDIB, PRKACA, RAB5B, DYNC1LI1, RAB5A, RAB11B, PRKACB, ADCY6",0.636388020107856,0.154281982033341,FALSE +"HCC95","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.32187,-0.937,0.514,6854,0.834,"AKT2, NFAT5, MAPKAPK3, AKT3, PPP3CC, MAPK14, MAPK1, PRKCA, PLCG1, MAPK3, AKT1, PRKCG, MAPKAPK2, PIK3CB, PPP3R1, PPP3R2, PLA2G12A, PRKCB, NFATC2, SPHK2",0.289036881004724,0.0788339493622613,FALSE +"HCC95","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.58265,-1.71,0.0353,7120,0.271,"ATP6V0A2, ATP6V1F, ATP6V1H, PRKACA, PRKCA, ATP6V1B2, ATP6V1A, ATP6V1C2, ATP6V0A1, TCIRG1, ATP6V1C1, ATP6V1D, PLCG1, KDELR3, ATP6V1E1, ACTG1, ATP6V1G1, PRKCG, TJP2, ATP6V0D1, PRKACB, PRKCB",1.45222529461218,0.567030709125594,FALSE +"HCC95","Input","KEGG_VIRAL_MYOCARDITIS",0.36306,1.06,0.35,733,0.716,"CAV1, MYH4, CD40, RAC2, RAC3",0.455931955649724,0.145086977692144,FALSE +"HCC95","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.24695,-0.712,0.835,6641,0.942,"PPP2R5B, CAMK2D, CTNNB1, DAAM2, WNT11, CXXC4, GSK3B, NFAT5, PPP2R5A, ROCK1, ROCK2, PPP3CC, CACYBP, PRKACA, PRKCA, DAAM1, PPP2CB, CTBP2, PRKCG, VANGL2, NKD1, NKD2, FOSL1, PPP3R1, PPP3R2, PRKACB, PRKCB, NFATC2, PSEN1, SMAD2",0.0783135245163979,0.0259490972071227,FALSE +"H1650","Input","KEGG_ABC_TRANSPORTERS",-0.42713,-1.35,0.139,7453,0.451,"ABCC10, ABCC2, ABCD4, ABCA10, ABCB1, ABCA3, ABCC5, ABCB6, ABCC4, ABCB4",0.856985199745905,0.345823458122039,FALSE +"H1650","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.18586,-0.575,0.971,7475,0.985,"STAT5A, STAT5B, PIM1, IKBKB, EIF4EBP1, MYC",0.0127807700919951,0.00656376950238827,FALSE +"H1650","Input","KEGG_ADHERENS_JUNCTION",0.37331,1.15,0.26,2728,0.466,"ERBB2, CTNNA1, CTNNB1, NECTIN1, TGFBR2, CTNND1, CTNNA2, EGFR, PTPRM, SMAD3, PTPRJ, PTPRF, MAPK3, MAP3K7, NECTIN2, CDH1, BAIAP2, ACTN4, PTPN1, CREBBP, EP300, ACTG1, SRC, CDC42, SMAD2, RAC1, NECTIN4, FYN, ACTN1, CSNK2A1, CSNK2A2, VCL, ACTB, RHOA, PTPN6",0.585026652029182,0.33161408331,FALSE +"H1650","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.44472,1.36,0.138,2213,0.358,"CD36, PRKCQ, RXRA, SLC2A1, ACSL1, TRADD, ACSL5, ACSL6, STAT3, AKT2, AKT3, PRKAA1, MTOR, CHUK, ACACB, CPT1A, NFKB1",0.860120913598763,0.446116973356126,FALSE +"H1650","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.49748,1.5,0.0606,1055,0.344,"ABAT, GLUL, ASS1, GLS, GLS2, GPT2",1.21752737583371,0.46344155742847,FALSE +"H1650","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.32604,1,0.398,1661,0.61,"ATP1B3, SFN, ATP1B1, MAPK3, ATP1A3, PIK3R3, ATP1A1, ATP1A4, PRKCA",0.400116927926312,0.214670164989233,FALSE +"H1650","Input","KEGG_ALZHEIMERS_DISEASE",0.19217,0.584,0.977,1731,0.991,"NDUFA2, PPP3R2, MME, PPP3R1, CAPN2, PPP3CA, CAPN1, PPP3CB, CYC1, UQCR10, SDHD, ITPR2, FAS, GAPDH, CASP7, MAPK3, ATP2A2, EIF2AK3, SDHC, CYCS, GNAQ, COX6A1, CASP8",0.0101054362812269,0.00392634551472468,FALSE +"H1650","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.45506,-1.4,0.111,6631,0.439,"MARS2, MTFMT, PARS2, HARS2, AARS2, NARS2, CARS2, TARS2, WARS2",0.954677021213343,0.357535479757879,FALSE +"H1650","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.24495,0.76,0.79,1750,0.856,"PGM1, MPI, NAGK, GNE, UGP2, UAP1, CYB5R3, GMPPB, GMPPA, HEXA, HK1",0.102372908709559,0.0675262353228468,FALSE +"H1650","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.30793,-0.953,0.493,8445,0.694,"NEFH, NEFM, PRPH, PRPH2, NEFL, TP53",0.30715308072277,0.158640529545145,FALSE +"H1650","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.60892,1.87,0.018,1015,0.205,"CD74, HSPA2, HSPA1L, TAPBP, CTSL, B2M, TAP1, HSPA6, TAP2",1.74472749489669,0.688246138944246,TRUE +"H1650","Input","KEGG_APOPTOSIS",0.39026,1.2,0.204,1731,0.435,"PPP3R2, ENDOD1, PPP3R1, PRKACB, CAPN2, PPP3CA, CAPN1, PPP3CB, PRKAR1B, TRADD, ENDOG, PRKAR1A, FAS, MYD88, CASP7, AKT2, AKT3, PIK3R3, CYCS, PRKACA, CASP8",0.690369832574101,0.361510743045363,FALSE +"H1650","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.45723,1.41,0.111,485,0.348,"PTGES, GGT1, CYP4F3, GPX6, GPX7",0.954677021213343,0.458420756053419,FALSE +"H1650","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.29352,0.881,0.575,1107,0.72,"GLUL, ALDH7A1, GATM, P4HA1, PYCR3, ASS1, AOC1, DAO, GLS, GLS2, OAT, P4HA2",0.24033215531037,0.142667503568732,FALSE +"H1650","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.46079,1.43,0.106,1475,0.354,"ITGA4, ITGA6, ITGA3, ITGB4, ITGA1, ITGB1, ITGA2, ITGA5, SLC8A1, CTNNA1, CTNNB1, ITGB5, DSC2, CTNNA2, DSG2, DAG1, ITGAV, ITGB8, PKP2, ACTN4, ATP2A2, LMNA",0.97469413473523,0.450996737974212,FALSE +"H1650","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.57795,-1.8,0.0182,8393,0.32,"UGDH, ALDH2, ALDH1B1",1.73992861201493,0.494850021680094,FALSE +"H1650","Input","KEGG_AXON_GUIDANCE",0.25901,0.789,0.744,1221,0.837,"ITGB1, PPP3R2, EPHB2, NFAT5, PPP3R1, SEMA3C, EFNA5, PPP3CA, PPP3CB, EPHB4, NTN4, SEMA4B, PTK2, SRGAP2, SRGAP3, RASA1, LIMK2, CFL2, MAPK3",0.128427064454121,0.07727454200674,FALSE +"H1650","Input","KEGG_BASAL_CELL_CARCINOMA",0.44841,1.35,0.162,763,0.362,"FZD2, FZD1, CTNNB1, APC",0.790484985457369,0.441291429466834,FALSE +"H1650","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.57937,-1.81,0.026,6190,0.383,"TAF12, GTF2E1, TAF7, TAF10, TAF9, GTF2E2, GTF2IRD1, GTF2H3, GTF2H4, GTF2H2, GTF2H1, GTF2F2, GTF2F1, TAF9B",1.58502665202918,0.416801226031377,FALSE +"H1650","Input","KEGG_BASE_EXCISION_REPAIR",-0.49377,-1.52,0.102,7094,0.341,"MBD4, POLE3, APEX1, MPG, FEN1, PARP1, PARP2, HMGB1, POLB",0.991399828238082,0.467245621007502,FALSE +"H1650","Input","KEGG_BETA_ALANINE_METABOLISM",0.43588,1.33,0.146,330,0.372,"ABAT, ALDH7A1",0.835647144215563,0.429457060118102,FALSE +"H1650","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.76918,2.35,0,966,0.0462,"ACOT4, SCD5, ACOT1, ACOX3, FADS2, SCD, ACOT2, ACAA1, TECR, ACOX1",Inf,1.33535802444387,TRUE +"H1650","Input","KEGG_BLADDER_CANCER",-0.35229,-1.07,0.343,8588,0.58,"E2F3, RB1, TP53, MYC",0.464705879957229,0.236572006437063,FALSE +"H1650","Input","KEGG_BUTANOATE_METABOLISM",0.31998,0.971,0.459,2397,0.647,"ABAT, ALDH7A1, ALDH3A2, OXCT1, AKR1B10, ACAT2, AACS, HMGCS1, ALDH5A1, EHHADH",0.338187314462739,0.1890957193313,FALSE +"H1650","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.31122,0.971,0.475,1393,0.647,"PPP3R2, NFAT5, MALT1, PPP3R1, PPP3CA, PPP3CB, VAV2, MAPK3, AKT2, AKT3, PIK3R3, SOS1",0.323306390375133,0.1890957193313,FALSE +"H1650","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.47802,1.46,0.0847,1687,0.327,"GNA15, CAMK2G, ERBB4, BST1, PPP3R2, CAMK2B, ERBB2, PTK2B, PPP3R1, PRKACB, SLC8A1, PPP3CA, PPP3CB, PLCD1, PHKB, PHKA1, CAMK2D, EGFR, ATP2B1, TACR1, ITPR2, GNAS, ATP2B2, ATP2B4, ADCY3, ADCY8, P2RX4, SPHK2, VDAC2, ATP2A2, TNNC1, PRKACA, PRKCA, GNAQ",1.07211658966929,0.485452247339714,FALSE +"H1650","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.5211,1.58,0.0716,2768,0.329,"TPM2, SLC8A1, CYC1, UQCR10, TPM1, SLC9A6, SLC9A1, ATP1B3, ATP1B1, ATP1A3, ATP2A2, ATP1A1, ATP1A4, TNNC1, COX6A1, UQCRC2, UQCRFS1, CACNA2D2, UQCRC1, UQCRQ, COX6B1, COX7A2, COX7A2L, COX4I1, UQCRH, TPM4",1.14508697769214,0.482804102050026,FALSE +"H1650","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.50982,1.53,0.0765,1325,0.348,"ITGA4, CD40, SDC1, CLDN6, SDC4, ITGA6, ITGB2, CD99, GLG1, ITGB1, CLDN4, CD274, CDH15, CDH3, F11R, SDC2, NECTIN1, OCLN, PVR, SDC3, ITGAV, PTPRM, CD276, PTPRF, ITGB8, NECTIN2, CDH1",1.11633856484638,0.458420756053419,FALSE +"H1650","Input","KEGG_CELL_CYCLE",-0.3834,-1.2,0.217,6889,0.49,"ORC4, MCM5, CDK7, ORC5, MCM2, MCM4, CDK6, STAG1, ORC3, MCM6, MCM7, CDKN2C, TGFB2, ORC1, TGFB3, MCM3, ORC2, HDAC2, ATM, ORC6, TFDP1, CDC20, ABL1, E2F3, RB1, TP53, MYC, CDKN1B",0.66354026615147,0.309803919971486,FALSE +"H1650","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.35263,1.06,0.348,1817,0.54,"STAT1, STAT2, PTK2B, PRKACB, ADCY6, TIAM1, ADCY5, PRKCD, PRKCZ, CCL15, VAV2, PTK2, ADCY3, ADCY8, GNG10, STAT3, TIAM2, MAPK3, ARRB1, AKT2, AKT3, PIK3R3, SOS1, PXN, CXCL6, GNG12, LYN, PRKACA, CXCR4, GNG5, ROCK1, RAP1A",0.458420756053419,0.267606240177031,FALSE +"H1650","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.41892,-1.3,0.158,7475,0.449,"STAT5A, CTBP1, TGFB2, STAT5B, TGFB3, TGFBR1, HDAC2, IKBKB, ABL1, E2F3, RB1, GAB2, TP53, MYC, CDKN1B",0.801342913045577,0.347753658996677,FALSE +"H1650","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.34031,1.06,0.332,2573,0.54,"SDHD, ACLY, OGDHL, PC, SDHC, OGDH, ACO2, SUCLG2, SDHB, IDH1, MDH1, DLD, SDHA, IDH2",0.478861916295964,0.267606240177031,FALSE +"H1650","Input","KEGG_COLORECTAL_CANCER",-0.21185,-0.654,0.885,7444,0.931,"MAPK8, TGFB2, TGFB3, TGFBR1, JUN, TP53, MYC",0.0530567293021746,0.0310503190186574,FALSE +"H1650","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.36354,1.12,0.282,973,0.491,"SERPINA1, PLAU, CD59, F8, CD55, PROC, C3, MBL2, PLAUR",0.549750891680639,0.308918507877032,FALSE +"H1650","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.53674,-1.68,0.0463,7781,0.282,"MPST, APIP, AMD1, CTH, MTAP",1.33441900898205,0.549750891680639,FALSE +"H1650","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.428,1.32,0.162,1738,0.361,"CD40, IFNGR1, IL18, TGFBR2, CCL15, KITLG, EGFR, LTBR, FAS, TNFRSF12A, HGF, CXCL6, FLT3, CXCR4, EPO",0.790484985457369,0.442492798094342,FALSE +"H1650","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.40082,1.25,0.185,640,0.407,"DDX58, CASP1, IL18, IRF3, ZBP1",0.732828271596986,0.39040559077478,FALSE +"H1650","Input","KEGG_DILATED_CARDIOMYOPATHY",0.48962,1.46,0.0892,1200,0.327,"ITGA4, ITGA6, ITGA3, ITGB4, TPM2, ITGA1, ITGB1, ITGA2, ITGA5, PRKACB, ADCY6, SLC8A1, ITGB5, ADCY5, TPM1, DAG1, GNAS, ITGAV, ADCY3, ADCY8, ITGB8",1.04963514562388,0.485452247339714,FALSE +"H1650","Input","KEGG_DNA_REPLICATION",-0.53658,-1.65,0.0369,5305,0.283,"SSBP1, POLD3, RFC2, RFC3, RFC5, RPA3, POLD2, RPA2, RPA1, RNASEH1, DNA2, PRIM1, RFC1, POLA1, MCM5, RFC4, MCM2, MCM4, POLE3, MCM6, PRIM2, MCM7, POLA2, FEN1, MCM3, RNASEH2A, RNASEH2C, RNASEH2B",1.43297363384094,0.54821356447571,FALSE +"H1650","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.48056,1.46,0.0809,2564,0.327,"EGFR, NOTCH3, MAPK3, SOS1, NOTCH2, SPIRE1",1.09205147838773,0.485452247339714,FALSE +"H1650","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.588,-1.85,0.0136,7630,0.437,"ADH4, ADH7, GSTZ1, FMO3, ALDH3A1, GSTM4, ADH1C, GSTM3, MAOA, GSTM2, GSTM1, GSTP1",1.86646109162978,0.359518563029578,FALSE +"H1650","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.37646,1.14,0.269,1024,0.474,"CDA, TYMP, TK1, TK2, CES1, CES2",0.570247719997592,0.324221658325915,FALSE +"H1650","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.52697,1.57,0.0639,1250,0.326,"ITGA4, SDC1, SDC4, ITGA6, ITGA3, ITGB4, CD36, ITGA1, ITGB1, LAMA5, ITGA2, ITGA5, SDC2, ITGB5, LAMA3, LAMA4, DAG1, SDC3, ITGAV, LAMB1, ITGB8, COL5A1",1.1944991418416,0.486782399932061,FALSE +"H1650","Input","KEGG_ENDOCYTOSIS",0.52654,1.65,0.0466,2260,0.308,"DNM3, HSPA2, TRAF6, EHD2, HSPA1L, EPN3, ERBB4, ASAP3, DAB2, EHD1, RAB31, PLD2, ASAP2, DNAJC6, PRKCZ, RAB11FIP5, RAB11A, EHD3, LDLRAP1, EGFR, HSPA6, AP2A1, PRKCI, SH3GLB2, PARD6B, ITCH, WWP1, PARD6G, RAB22A, AP2B1, TFRC, PSD, AP2S1, AP2M1, IQSEC1, ARRB1, PIKFYVE, VPS4A, EPN1, DNM1, VPS4B, ASAP1, RAB11B, NEDD4, PDCD6IP, HSPA1A, CHMP5, VPS45, CXCR4, SH3KBP1, RAB11FIP2, USP8, CBLB, EHD4, CLTC, SRC, ARF6, RBSN, CDC42, CHMP2A, EPN2, DNM2, RAB5B, RAB5C, ARFGAP1, ARFGAP3, VPS37B, STAMBP, RUFY1, EPS15, RAB4A",1.33161408331,0.511449283499556,FALSE +"H1650","Input","KEGG_ENDOMETRIAL_CANCER",0.38149,1.17,0.237,1393,0.457,"ERBB2, CTNNA1, CTNNB1, CTNNA2, APC, EGFR, MAPK3, AKT2, CDH1, AKT3, PIK3R3, SOS1",0.625251653989896,0.34008379993015,FALSE +"H1650","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.27897,-0.85,0.588,6538,0.729,"ATP6V1B2, ATP6V0A2, PAK1, ATP6V1A, ATP6V1D, ATP6V1F, GIT1, MAPK8, ATP6V1G1, ATP6V1H, ATP6V1B1, IKBKB, JUN, JAM3",0.230622673923862,0.137272471682025,FALSE +"H1650","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.22638,0.683,0.866,1393,0.919,"CAMK2G, ERBB4, CAMK2B, ERBB2, CAMK2D, PTK2, EGFR, GAB1, MAPK3, AKT2, AKT3, PIK3R3, SOS1",0.0624821079826534,0.0366844886138887,FALSE +"H1650","Input","KEGG_ETHER_LIPID_METABOLISM",0.63829,1.97,0.00904,1323,0.147,"PLPP3, PLD2, LPCAT2, LPCAT4, PAFAH2, PLPP1, LPCAT1",2.04383156952464,0.832682665251824,TRUE +"H1650","Input","KEGG_FATTY_ACID_METABOLISM",0.28502,0.894,0.558,1307,0.718,"ACOX3, ALDH7A1, ACSL1, ACSL5, ACAA1, ACOX1, ACSL6, ALDH3A2",0.253365801062421,0.1438755557577,FALSE +"H1650","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.2185,0.69,0.873,2710,0.925,"PRKCD, VAV2, MAPK12, MAPK3, AKT2, AKT3, PIK3R3, SOS1, PRKCE, MAPK14, LYN, PRKCA, MAPK13, PLCG2, RAC1, FYN, HRAS, AKT1, MAP2K6, PLA2G12A, PIK3CB",0.0589857562944303,0.0338582672609674,FALSE +"H1650","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.3819,1.17,0.246,1661,0.457,"PLPP3, DNM3, ASAP3, PLD2, ASAP2, PRKCD, AMPH, VAV2, LIMK2, VASP, CFL2, PLPP1, MAPK3, GSN, PIKFYVE, AKT2, DNM1, AKT3, PIK3R3, SPHK2, ASAP1, PRKCE, LYN, ARPC1B, PRKCA",0.609064892896621,0.34008379993015,FALSE +"H1650","Input","KEGG_FOCAL_ADHESION",0.38179,1.19,0.238,1958,0.442,"ITGA4, ITGA6, ITGA3, ITGB4, CAV2, CAV1, ITGA1, ITGB1, ARHGAP35, ERBB2, LAMA5, ITGA2, ITGA5, CAPN2, CTNNB1, ITGB5, FLNC, LAMA3, LAMA4, VAV2, PTK2, EGFR, ITGAV, LAMB1, VASP, ITGB8, MAPK3, COL5A1, AKT2, ACTN4, AKT3, PIK3R3, HGF, SOS1, PXN, MYL9, TNC, PRKCA, ROCK1, RAP1A, MYL12A, ACTG1, SRC, FLT4, CDC42",0.623423042943488,0.354577730650908,FALSE +"H1650","Input","KEGG_FOLATE_BIOSYNTHESIS",0.70452,2.2,0.00185,12,0.0797,"ALPI, ALPP",2.73282827159699,1.09854167860389,TRUE +"H1650","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.25161,0.779,0.74,2497,0.839,"MPI, PFKFB4, AKR1B1, PFKP, PFKFB2, GMPPB, MTMR1, GMPPA, AKR1B10, HK1, PFKL, PMM2, ALDOA, PHPT1, HK2",0.130768280269024,0.0762380391712997,FALSE +"H1650","Input","KEGG_GALACTOSE_METABOLISM",0.42858,1.28,0.162,998,0.396,"PGM1, B4GALT1, UGP2, GLB1, AKR1B1, PFKP",0.790484985457369,0.402304814074488,FALSE +"H1650","Input","KEGG_GAP_JUNCTION",0.3026,0.938,0.478,2086,0.664,"PRKACB, ADCY6, ADCY5, TUBA4A, EGFR, ITPR2, GNAS, ADCY3, ADCY8, MAPK3, SOS1, PRKACA, PRKCA, GNAQ, CDK1, SRC, MAPK7, GNA11",0.320572103387881,0.177831920631982,FALSE +"H1650","Input","KEGG_GLIOMA",-0.27733,-0.862,0.568,8588,0.722,"E2F3, CALM2, RB1, CALML3, TP53",0.245651664288981,0.141462802430361,FALSE +"H1650","Input","KEGG_GLUTATHIONE_METABOLISM",-0.31026,-0.945,0.464,7811,0.674,"GPX4, GSTZ1, GCLC, GPX3, GSTM4, GSTM3, GPX2, GSTM2, GSTM1, GSTP1",0.333482019445119,0.17134010346468,FALSE +"H1650","Input","KEGG_GLYCEROLIPID_METABOLISM",0.42595,1.32,0.136,1307,0.361,"PLPP3, MGLL, DGKA, CEL, ALDH7A1, MBOAT2, AKR1B1, AGPAT4, PLPP1, ALDH3A2",0.866461091629782,0.442492798094342,FALSE +"H1650","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40271,1.21,0.203,1709,0.435,"PLPP3, PEMT, DGKA, MBOAT7, PLD2, LPCAT2, LPCAT3, LPCAT4, MBOAT2, PLA2G15, AGPAT4, PISD, PLPP1, LPCAT1, DGKB, CDS1, AGPAT2",0.692503962086787,0.361510743045363,FALSE +"H1650","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.2957,-0.899,0.549,6701,0.705,"GLDC, CHDH, GAMT, SHMT2, PSPH, PIPOX, MAOA, CTH",0.260427655549908,0.151810883008601,FALSE +"H1650","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.263,-0.806,0.683,7561,0.793,"PGK2, ADH4, ADH7, FBP2, ENO2, PCK2, FBP1, GCK, ALDH3A1, ALDOC, ADH1C, ALDH2, ALDH1B1",0.165579296318467,0.100726812682396,FALSE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.61807,1.85,0.0237,2827,0.207,"B3GALT6, CHST14, CHSY1, XYLT2, B3GAT3, B4GALT7",1.6252516539899,0.684029654543082,TRUE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.3413,-1.07,0.318,8794,0.58,"HS6ST2",0.497572880015567,0.236572006437063,FALSE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66224,1.99,0.0131,1356,0.149,"B4GALT1, ST3GAL2, B4GALT4",1.88272870434424,0.826813731587726,TRUE +"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.53564,1.65,0.0482,1663,0.308,"GALNS, ARSB, GLB1, HPSE, NAGLU, HEXA",1.31695296176115,0.511449283499556,FALSE +"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.56792,1.73,0.0368,1663,0.272,"ST3GAL2, GLB1, HEXA",1.43415218132648,0.565431095965801,FALSE +"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.69372,2.12,0.00358,2389,0.0933,"ST3GAL2, HEXA, FUT1, NAGA",2.44611697335613,1.0301183562535,TRUE +"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.56773,1.79,0.0267,1356,0.244,"B3GNT3, B4GALT1, ST3GAL4, FUT3, B4GALT4",1.57348873863542,0.612610173661271,TRUE +"H1650","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.56312,1.73,0.0377,1311,0.272,"GPAA1, PIGT, PIGW, PIGS, PIGU, PIGK",1.42365864979421,0.565431095965801,FALSE +"H1650","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.37042,1.15,0.266,2268,0.466,"MTHFD2, GRHPR, ACO2, MDH1",0.575118363368933,0.33161408331,FALSE +"H1650","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.40632,1.23,0.191,2086,0.421,"CAMK2G, CAMK2B, PTK2B, PRKACB, ADCY6, PLD2, ADCY5, PRKCD, CAMK2D, MMP2, EGFR, ITPR2, GNAS, MAPK12, ADCY3, ADCY8, MAPK3, SOS1, MAPK14, PRKACA, PRKCA, GNAQ, MAPK13, SRC, CDC42, MAPK7, GNA11",0.718966632752272,0.375717904164332,FALSE +"H1650","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.24094,-0.734,0.771,8187,0.904,"SHH, FBXW11",0.112945621949043,0.0438315695246367,FALSE +"H1650","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.702,2.18,0.00373,853,0.0746,"ITGA4, ANPEP, ITGA6, ITGA3, CD36, CD9, ITGA1, CD14, ITGA2, MME, ITGA5, CD59, CD55, KITLG",2.42829116819131,1.12726117252733,TRUE +"H1650","Input","KEGG_HISTIDINE_METABOLISM",-0.51952,-1.59,0.0778,8386,0.319,"ALDH3A1, ALDH2, HNMT, ALDH1B1, MAOA, DDC",1.10902040301031,0.496209316942819,FALSE +"H1650","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.39924,-1.28,0.167,5027,0.457,"TOP3A, MRE11, SSBP1, POLD3, RPA3, POLD2, RPA2, RPA1, TOP3B, RAD51, MUS81, BLM",0.777283528852417,0.34008379993015,FALSE +"H1650","Input","KEGG_HUNTINGTONS_DISEASE",0.13224,0.41,1,1932,1,"TGM2, NDUFA2, DNAH2, CYC1, UQCR10, SDHD, AP2A1, AP2B1, AP2S1, AP2M1, VDAC2, CREBBP, SDHC, EP300, CYCS, GNAQ, COX6A1, CASP8, UQCRC2, CLTC, UQCRFS1",0,0,FALSE +"H1650","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.45307,1.4,0.123,731,0.343,"ITGA4, ITGA6, ITGA3, ITGB4, TPM2, ITGA1, ITGB1, ITGA2, ITGA5, SLC8A1, ITGB5, ACE, TPM1, DAG1",0.910094888560602,0.464705879957229,FALSE +"H1650","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.25755,0.783,0.708,3028,0.84,"INPP4B, MINPP1, PLCD1, IMPA2, ITPK1, PI4KA, PIKFYVE, PIK3C2B, ISYNA1, INPP5K, PLCG2, INPP4A, PIK3C3, INPP1, INPPL1, PIP4K2C, PIK3CB, INPP5A, PIK3CA, PIK3CD, SYNJ1, PLCD3",0.149966742310231,0.0757207139381184,FALSE +"H1650","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.25849,0.799,0.704,1790,0.836,"PRKACB, PRKCZ, PRKAR1B, PHKB, PHKA1, PPP1R3D, PRKAR1A, PRKCI, FASN, GYS1, PTPRF, PKLR, MAPK3, AKT2, AKT3, PIK3R3, PTPN1, SOS1, PRKAA1, PPP1R3A, EXOC7, TRIP10, MTOR, ACACA, PRKACA, INPP5K, HK1, CBLB",0.152427340857888,0.0777937225609836,FALSE +"H1650","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.27213,0.816,0.692,1790,0.811,"IFNGR1, STAT1, STAT2, IRF9, STAT3, AKT2, AKT3, PIK3R3, SOS1, CREBBP, EP300, EPO, CBLB",0.159893905543242,0.090979145788844,FALSE +"H1650","Input","KEGG_LEISHMANIA_INFECTION",0.49823,1.53,0.0774,1829,0.348,"ITGA4, TRAF6, IFNGR1, STAT1, ITGB2, ITGB1, C3, MYD88, MAPK12, MAPK3, MAP3K7, MAPK14, CR1, CYBA, MAPK13",1.11125903931711,0.458420756053419,FALSE +"H1650","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.36077,1.12,0.276,1958,0.491,"ITGA4, CLDN6, ITGB2, CD99, ITGB1, CLDN4, ARHGAP35, PTK2B, F11R, CTNNA1, CTNNB1, OCLN, CTNND1, MMP2, CTNNA2, VAV2, PTK2, MAPK12, VASP, EZR, ACTN4, PIK3R3, PXN, MYL9, MAPK14, PRKCA, CXCR4, CYBA, ROCK1, RAP1A, MAPK13, MYL12A, ACTG1, MSN, CDC42",0.559090917934782,0.308918507877032,FALSE +"H1650","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.4291,-1.31,0.169,8635,0.483,"ALDH2, ALDH1B1",0.772113295386326,0.316052869248488,FALSE +"H1650","Input","KEGG_LONG_TERM_DEPRESSION",0.22147,0.69,0.889,2091,0.925,"GNAO1, ITPR2, GNAS, MAPK3, LYN, PRKCA, GNAQ, CACNA1A, GNA11, GNA12",0.0510982390297863,0.0338582672609674,FALSE +"H1650","Input","KEGG_LONG_TERM_POTENTIATION",0.41177,1.26,0.184,1817,0.4,"CAMK2G, PPP3R2, CAMK2B, PPP3R1, PRKACB, PPP3CA, PPP3CB, CAMK2D, ITPR2, ADCY8, MAPK3, CREBBP, EP300, RPS6KA1, PRKACA, PRKCA, GNAQ, RAP1A",0.735182176990464,0.397940008672038,FALSE +"H1650","Input","KEGG_LYSINE_DEGRADATION",-0.36126,-1.1,0.302,7926,0.588,"KMT5A, NSD2, SETMAR, KMT5C, PIPOX, SETDB2, NSD3, AASS, ALDH2, ALDH1B1",0.519993057042849,0.230622673923862,FALSE +"H1650","Input","KEGG_LYSOSOME",0.48056,1.47,0.0766,1219,0.371,"GALC, AP1M2, CTSH, AP1S1, LIPA, GM2A, CTSL, CTSZ, AP1G1, CTSK, CTSO, GALNS, CTSV, ARSB, GGA2, LAMP3, PLA2G15, TCIRG1, GLB1, CTSA, ARSA, MANBA, AP1B1, NAPSA, CTSF, AP1S3",1.1157712303674,0.430626090384954,FALSE +"H1650","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.33128,1.01,0.421,1661,0.599,"HSPA2, TRAF6, HSPA1L, HSPB1, CD14, PPP3R2, MAP3K5, TAOK3, PPP3R1, PRKACB, RRAS, PPP3CA, PPP3CB, TGFBR2, FLNC, MAP3K20, FGF13, FGF2, EGFR, MAPKAPK3, HSPA6, NFKB2, CDC25B, FAS, RASA1, MAPK12, MAPK8IP3, MAPK3, STK3, MAP3K7, ARRB1, AKT2, AKT3, SOS1, GNG12, HSPA1A, RPS6KA1, MAPK14, PRKACA, PRKCA",0.375717904164332,0.222573177610689,FALSE +"H1650","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.48931,-1.54,0.0846,6087,0.345,"HNF1A, HNF4A, PDX1, HES1, GCK, FOXA2",1.07262963696098,0.462180904926726,FALSE +"H1650","Input","KEGG_MELANOGENESIS",0.44204,1.34,0.142,1687,0.367,"CAMK2G, GNAO1, CAMK2B, FZD2, PRKACB, ADCY6, FZD1, CTNNB1, ADCY5, CAMK2D, KITLG, GNAS, ADCY3, ADCY8, MAPK3, CREBBP, EP300, PRKACA, PRKCA, GNAQ",0.847711655616944,0.435333935747911,FALSE +"H1650","Input","KEGG_MELANOMA",0.23353,0.714,0.815,1392,0.915,"FGF13, FGF2, EGFR, MAPK3, AKT2, CDH1, AKT3, PIK3R3, HGF",0.0888423912600234,0.0385789059335517,FALSE +"H1650","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.54792,-1.69,0.0562,7630,0.351,"ADH4, ADH7, GSTZ1, ALDH3A1, GSTM4, ADH1C, AKR1C2, AKR1C1, GSTM3, AKR1C3, GSTM2, GSTM1, GSTP1",1.25026368443094,0.454692883534176,FALSE +"H1650","Input","KEGG_MISMATCH_REPAIR",-0.40526,-1.26,0.191,5305,0.444,"SSBP1, POLD3, RFC2, RFC3, RFC5, RPA3, POLD2, RPA2, RPA1, MSH2, RFC1, MSH6, RFC4",0.718966632752272,0.35261702988538,FALSE +"H1650","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.30813,0.938,0.486,3004,0.664,"MAPK3, AKT2, AKT3, PIK3R3, PRKAA1, CAB39, RICTOR, RPS6KA1, MTOR, RPTOR, TSC2, AKT1, RPS6KA3, RHEB, PIK3CB, PIK3CA, RPS6KA6, PIK3CD, RPS6KA2, PDPK1",0.313363730737707,0.177831920631982,FALSE +"H1650","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.4509,1.41,0.104,1393,0.348,"IFNGR1, ITGB2, RAET1L, ULBP2, PPP3R2, NFAT5, PTK2B, PPP3R1, PPP3CA, PPP3CB, VAV2, FAS, MAPK3, PIK3R3, SOS1",0.98296666070122,0.458420756053419,FALSE +"H1650","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.34133,-1.07,0.349,7011,0.58,"PARD3, P2RY11, GRIN1, CHRM3, CGA, LTB4R2, F2",0.45717457304082,0.236572006437063,FALSE +"H1650","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.21656,0.675,0.869,2954,0.921,"TRAF6, CAMK2G, CAMK2B, MAP3K5, ARHGDIB, PRKCD, CAMK2D, SH2B1, YWHAZ, GAB1, MAPK12, MAPK3, AKT2, AKT3, PIK3R3, SOS1, RPS6KA1, MAPK14, YWHAB, RAP1A, MAPK13, CDC42, MAPK7, PLCG2, NFKB1, RAC1, YWHAE, HRAS, MAPKAPK2, MAP3K3, AKT1, RPS6KA3, RIPK2, PIK3CB, RHOA, BCL2, RPS6KA4, IRS1, PIK3CA, RPS6KA6, MAGED1, PIK3CD, RPS6KA2",0.0609802235513335,0.0357403698031511,FALSE +"H1650","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.44745,1.38,0.127,205,0.351,"NNMT, QPRT, BST1",0.896196279044043,0.454692883534176,FALSE +"H1650","Input","KEGG_NITROGEN_METABOLISM",-0.4414,-1.38,0.115,7821,0.438,"GLUD2, CPS1, CA14, CA1, ASNS, CTH, CA8",0.939302159646388,0.3585258894959,FALSE +"H1650","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.37018,1.15,0.275,1987,0.466,"TRAF6, CASP1, IL18, NAIP, MAPK12, MAPK3, MAP3K7, MAPK14, CASP8, CASP5, MAPK13, CHUK, PYCARD",0.560667306169737,0.33161408331,FALSE +"H1650","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.46852,-1.47,0.102,4762,0.374,"NHEJ1, MRE11, PRKDC, XRCC4, POLM, FEN1",0.991399828238082,0.42712839779952,FALSE +"H1650","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.30704,-0.936,0.483,8588,0.673,"E2F3, RB1, FOXO3, FHIT, TP53",0.316052869248488,0.171984935776023,FALSE +"H1650","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.22704,-0.713,0.848,7053,0.901,"HES1, SNW1, LFNG, KAT2A, CTBP1, DLL3, HDAC2, JAG1",0.0716041477432862,0.045275209020937,FALSE +"H1650","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.42132,-1.27,0.195,5584,0.45,"RFC3, RFC5, RPA3, POLD2, XPC, RPA2, RPA1, CCNH, ERCC8, RFC1, CDK7, RFC4, POLE3, ERCC6, ERCC3, GTF2H5, CUL4A, GTF2H3, GTF2H4, GTF2H2, GTF2H1, MNAT1, ERCC5",0.709965388637482,0.346787486224656,FALSE +"H1650","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.33445,1.03,0.379,2219,0.571,"B4GALT1, MAN2A2, MAN1B1, MAN2A1, TUSC3, STT3B, ALG2, MGAT1, DPM1, GANAB, MAN1A2, RFT1, DDOST",0.421360790031928,0.243363891754152,FALSE +"H1650","Input","KEGG_OLFACTORY_TRANSDUCTION",0.36076,1.11,0.31,668,0.493,"CAMK2G, CAMK2B, PRKACB, CAMK2D",0.508638306165727,0.30715308072277,FALSE +"H1650","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.22552,-0.709,0.827,5223,0.89,"TYMS, ATIC, MTHFD1L, MTR, MTFMT, SHMT2",0.0824944904474534,0.0506099933550872,FALSE +"H1650","Input","KEGG_OOCYTE_MEIOSIS",0.41873,1.29,0.161,1812,0.391,"CAMK2G, PPP3R2, CAMK2B, PPP3R1, PRKACB, ADCY6, PPP3CA, PPP3CB, ADCY5, CAMK2D, AR, ITPR2, PPP2R5E, YWHAZ, MAPK12, ADCY3, ADCY8, PLK1, MAPK3, SKP1, RPS6KA1, PRKACA, PPP2R5A, CDK1, YWHAB",0.79317412396815,0.407823242604133,FALSE +"H1650","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.35693,1.1,0.302,1663,0.502,"GLB1, MANBA, MAN2B2, HEXA",0.519993057042849,0.299296282854981,FALSE +"H1650","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.13403,0.408,1,2760,1,"NDUFA2, CYC1, UQCR10, LHPP, TCIRG1, SDHD, COX15, SDHC, COX6A1, ATP12A, ATP6V1C2, UQCRC2, UQCRFS1, SDHB, ATP6V1C1, UQCRC1, NDUFA3, UQCRQ, SDHA, COX17, COX6B1, COX7A2, COX7A2L, COX4I1, NDUFA4, UQCRH",0,0,FALSE +"H1650","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.81624,2.49,0,683,0.0158,"GALNT6, C1GALT1, C1GALT1C1, GALNT14, GALNT15, GALNT10, GALNT13, GALNT7, GALNT3, GALNT12, GALNT2, ST3GAL2, B4GALT5",Inf,1.80134291304558,TRUE +"H1650","Input","KEGG_P53_SIGNALING_PATHWAY",0.44078,1.38,0.11,1793,0.351,"TP53I3, SERPINB5, CD82, EI24, RRM2, DDB2, FAS, RRM2B, SFN, IGFBP3, CYCS, CHEK2, CASP8, CDK1",0.958607314841775,0.454692883534176,FALSE +"H1650","Input","KEGG_PANCREATIC_CANCER",0.2311,0.702,0.842,2235,0.925,"STAT1, ERBB2, TGFBR2, EGFR, SMAD3, RALA, STAT3, MAPK3, AKT2, AKT3, PIK3R3, RALB, CDC42, JAK1, CHUK, SMAD2, NFKB1, RAC1",0.0746879085003505,0.0338582672609674,FALSE +"H1650","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.3653,1.11,0.278,1470,0.493,"PPCS, BCAT2, PANK4",0.555955204081924,0.30715308072277,FALSE +"H1650","Input","KEGG_PARKINSONS_DISEASE",0.19018,0.582,0.965,837,0.984,"UBE2L6, UBA7, NDUFA2, CYC1, UQCR10, SDHD",0.0154726866562074,0.00700490156865849,FALSE +"H1650","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.31159,0.944,0.475,1958,0.667,"ITGB1, CD14, CTNNB1, OCLN, TUBA4A, YWHAZ, CDH1, EZR, ARPC1B, PRKCA, ROCK1, ACTG1, CDC42",0.323306390375133,0.175874166083451,FALSE +"H1650","Input","KEGG_PATHWAYS_IN_CANCER",0.27649,0.857,0.619,1661,0.749,"TRAF6, ITGA6, STAT1, ITGA3, ITGB1, ERBB2, LAMA5, ITGA2, FZD2, RXRA, FZD1, CTNNA1, CTNNB1, SLC2A1, TGFBR2, MMP2, LAMA3, LAMA4, CTNNA2, APC, FGF13, FGF2, KITLG, AR, PTK2, EGFR, NFKB2, ITGAV, FAS, LAMB1, SMAD3, RARA, RALA, STAT3, MAPK3, AKT2, CDH1, AKT3, PIK3R3, HGF, SOS1, DAPK1, CKS1B, CREBBP, FLT3, EP300, MTOR, CYCS, PRKCA",0.208309350979882,0.125518182300534,FALSE +"H1650","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.42783,-1.3,0.169,8393,0.449,"UGDH, CRYL1",0.772113295386326,0.347753658996677,FALSE +"H1650","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.27629,0.839,0.642,998,0.775,"PGM1, RBKS, H6PD, PFKP",0.192464971931147,0.11069829749369,FALSE +"H1650","Input","KEGG_PEROXISOME",0.48695,1.5,0.0926,2573,0.344,"PXMP4, ACOX3, SLC25A17, DECR2, MVK, ECH1, ACSL1, ACSL5, ACOT8, ACAA1, ABCD1, CROT, DAO, AMACR, ACOX1, GSTK1, HACL1, ACSL6, PEX13, HSD17B4, ABCD3, CAT, CRAT, PXMP2, PEX3, PEX14, PEX11A, AGPS, SCP2, ECI2, IDH1, PRDX1, EHHADH, ACSL3, PRDX5, NUDT19, PEX26, IDH2",1.03338901331807,0.46344155742847,FALSE +"H1650","Input","KEGG_PHENYLALANINE_METABOLISM",-0.59458,-1.86,0.0211,8386,0.632,"ALDH3A1, MAOA, DDC",1.67571754470231,0.199282921717615,FALSE +"H1650","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25482,0.776,0.712,1672,0.837,"INPP4B, DGKA, PLCD1, IMPA2, ITPR2, ITPK1, PI4KA, PIKFYVE, PIK3R3, PIK3C2B, DGKB, CDS1, PRKCA, INPP5K",0.147520006363144,0.07727454200674,FALSE +"H1650","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.53052,1.63,0.055,1730,0.314,"CP, EARS2, FTH1, BLVRB, COX15, HCCS, HMOX1, UROS, FECH",1.25963731050576,0.503070351926785,FALSE +"H1650","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.39589,1.21,0.21,1093,0.435,"SCD5, CD36, SLC27A6, ACOX3, FADS2, SCD, RXRA, ACSL1, ACSL5, SLC27A4, ACAA1, ACOX1, ACSL6",0.677780705266081,0.361510743045363,FALSE +"H1650","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.41756,1.27,0.15,1109,0.394,"CYP7B1, AMACR, HSD17B4",0.823908740944319,0.404503778174426,FALSE +"H1650","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.52972,1.62,0.0496,1156,0.309,"CD40, TAP1, TAP2, ADA",1.3045183235098,0.510041520575165,FALSE +"H1650","Input","KEGG_PRION_DISEASES",-0.32333,-0.994,0.373,8618,0.657,"C9, NCAM1",0.428291168191312,0.182434630440219,FALSE +"H1650","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.40222,1.2,0.221,1829,0.435,"PRKACB, ADCY6, ADCY5, CDC25B, MAPK12, ADCY3, ADCY8, PLK1, MAPK3, AKT2, FZR1, AKT3, PIK3R3, RPS6KA1, MAPK14, PRKACA, CDK1, MAPK13",0.655607726314889,0.361510743045363,FALSE +"H1650","Input","KEGG_PROPANOATE_METABOLISM",-0.28258,-0.865,0.577,8180,0.751,"ACSS3, PCCB, ALDH6A1, PCCA, ALDH2, ALDH1B1",0.238824186844269,0.124360062995832,FALSE +"H1650","Input","KEGG_PROSTATE_CANCER",-0.31824,-0.979,0.438,8368,0.666,"IKBKB, E2F3, RB1, TP53, GSTP1, CDKN1B",0.3585258894959,0.176525770829699,FALSE +"H1650","Input","KEGG_PROTEASOME",0.31048,0.958,0.464,263,0.656,"PSMB10, PSMB9",0.333482019445119,0.18309616062434,FALSE +"H1650","Input","KEGG_PROTEIN_EXPORT",-0.16757,-0.51,0.994,1481,0.991,"SEC62, SRP19, SRP54, SRPRA, SRP68, SRP72, SPCS1, HSPA5, SPCS3, SRPRB, SPCS2, SEC11A, OXA1L, IMMP1L, SEC61B, SRP14, SEC61A1, SRP9, SEC63, SEC11C",0.00261361560268669,0.00392634551472468,FALSE +"H1650","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.43619,1.32,0.157,2268,0.361,"GLS, GLS2, ATP1B3, ATP1B1, ATP1A3, ATP1A1, ATP1A4, CA2, MDH1",0.804100347590766,0.442492798094342,FALSE +"H1650","Input","KEGG_PURINE_METABOLISM",-0.22859,-0.72,0.812,5972,0.909,"APRT, POLR3F, GMPS, POLR1B, POLR1A, POLR2I, PRPS1, PRPS1L1, POLR3H, POLR3G, POLR2D, POLR1E, NME2, PDE6D, GUK1, POLR3C, ITPA, PRIM1, POLR2C, POLR2H, NUDT2, POLA1, POLR2L, PNP, PFAS, AK2, POLR2E, NME7, POLE3, AK1, NT5C, PRIM2, NUDT5, NME1, AK5, POLA2, GMPR2, PDE3A, PDE4A, PDE1C, POLR1C, POLR1D, GMPR, XDH, IMPDH1, NPR2, FHIT",0.0904439707588247,0.0414361167780325,FALSE +"H1650","Input","KEGG_PYRIMIDINE_METABOLISM",0.19702,0.615,0.944,1078,0.976,"CDA, CMPK2, NME3, TYMP, RRM2, NME4, TK1, TK2, DHODH, RRM2B",0.025028005701931,0.0105501823333082,FALSE +"H1650","Input","KEGG_PYRUVATE_METABOLISM",0.23467,0.731,0.816,2433,0.897,"ALDH7A1, ACSS2, AKR1B1, ME3, PKLR, ALDH3A2, PC, ACACA, GRHPR, ACAT2, ACSS1, ACACB, MDH1, DLD, ME2",0.0883098412461389,0.0472075569559079,FALSE +"H1650","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.40176,1.23,0.2,1645,0.421,"ITGA4, ITGA6, ITGA3, ITGB4, ITGB2, ITGA1, ITGB1, CD14, MYH14, ARHGAP35, ITGA2, ITGA5, RDX, RRAS, TIAM1, ITGB5, FGD3, APC, FGF13, FGF2, VAV2, PTK2, EGFR, SLC9A1, ITGAV, LIMK2, CFL2, MYH9, ITGB8, TIAM2, MAPK3, GSN, PIKFYVE, BAIAP2, EZR, ACTN4, PIK3R3, SOS1, PXN, GNG12, MYL9, ARPC1B, CYFIP2, NCKAP1",0.698970004336019,0.375717904164332,FALSE +"H1650","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.28536,0.888,0.6,2369,0.715,"GABARAPL2, GABARAPL1, PRKAA1, PIK3R4, ATG4B, ATG4A, PIK3C3",0.221848749616356,0.145693958198919,FALSE +"H1650","Input","KEGG_RENAL_CELL_CARCINOMA",0.22774,0.688,0.824,3477,0.92,"SLC2A1, GAB1, MAPK3, AKT2, AKT3, PIK3R3, HGF, SOS1, CREBBP, EP300, RAP1A, CDC42, RAC1, HRAS, PAK5, PAK6, AKT1, CUL2, PAK4, PIK3CB, PIK3CA, PIK3CD, ELOB, CRKL, PIK3R2, RBX1, MAPK1, MAP2K1, FLCN, PAK2, KRAS, NRAS",0.0840727883028842,0.0362121726544447,FALSE +"H1650","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.6738,2.06,0.00538,843,0.117,"CPA3, ANPEP, MME, ACE, CTSA",2.26921772433361,0.931814138253838,TRUE +"H1650","Input","KEGG_RETINOL_METABOLISM",-0.33223,-1.04,0.367,7630,0.614,"ADH4, ADH7, ADH1C, ALDH1A1, ALDH1A2",0.435333935747911,0.211831628858832,FALSE +"H1650","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.32563,-1.02,0.391,5705,0.63,"ACP1, FLAD1, TYR, MTMR6, ACP5, RFK",0.407823242604133,0.200659450546418,FALSE +"H1650","Input","KEGG_RIBOSOME",-0.37685,-1.16,0.242,4360,0.531,"RPS2, RPS19, RPL3, RPL23, RPL21, RPS17, RPL7A, RPL9, RPS9, RPSA, RPL17, MRPL13, RPL13, RPL6, RPS13, RPLP2, RPS5, RPS7, RPL31, RPL4, RPL32, RPL19, RPL22, RPL27A, RPS29, RPS27A, RPL29, RPLP1, RPS25, RPS28, UBA52, RPS27L, RPS20, FAU, RPS11, RPS12, RPS10, RPL24, RSL24D1, RPL36A, RPL36AL, RPS21, RPS6, RPS23, RPL38, RPL37, RPL22L1",0.616184634019569,0.274905478918531,FALSE +"H1650","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.46886,1.46,0.103,2213,0.327,"TRAF6, DDX58, ISG15, PIN1, IRF3, TRADD, CYLD, MAPK12, TRIM25, MAP3K7, MAPK14, CASP8, TKFC, MAPK13, CASP10, CHUK, TBK1, NFKB1",0.987162775294828,0.485452247339714,FALSE +"H1650","Input","KEGG_RNA_DEGRADATION",-0.28274,-0.862,0.567,5355,0.722,"EXOSC6, XRN2, DCP2, EXOSC9, EXOSC10, EXOSC5, LSM6, DIS3, LSM8, EDC3, EXOSC8, EXOSC1, MPHOSPH6, EXOSC4, LSM1, PAPOLG, HSPD1, LSM2, DDX6, CNOT2, LSM7, ENO2, LSM4, DCP1B",0.246416941107093,0.141462802430361,FALSE +"H1650","Input","KEGG_RNA_POLYMERASE",-0.53795,-1.68,0.0591,5344,0.282,"POLR3D, POLR2G, POLR3K, POLR3GL, POLR2J, POLR3F, POLR1B, POLR1A, POLR2I, POLR3H, POLR3G, POLR2D, POLR1E, POLR3C, POLR2C, POLR2H, POLR2L, POLR2E, POLR1C, POLR1D",1.22841251911874,0.549750891680639,FALSE +"H1650","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.36514,1.09,0.321,123,0.512,"GGT1, PAPSS2",0.493494967595128,0.290730039024169,FALSE +"H1650","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.29059,-0.912,0.519,8190,0.7,"FN1, LAMA1, IKBKB, E2F3, RB1, PTGS2, FHIT, TP53, MYC, ITGA2B, CDKN1B",0.284832642151542,0.154901959985743,FALSE +"H1650","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.28169,0.86,0.608,2752,0.751,"VAMP8, BET1L, YKT6, STX16, VAMP3, STX4, GOSR1, STX8, VAMP2, SNAP47, VAMP4, STX10",0.216096420727265,0.124360062995832,FALSE +"H1650","Input","KEGG_SPHINGOLIPID_METABOLISM",0.54486,1.66,0.0532,1396,0.336,"PLPP3, GALC, SPTLC2, GLB1, ARSA, DEGS1, SPTLC1, PLPP1, SPHK2",1.27408836770495,0.473660722610156,FALSE +"H1650","Input","KEGG_SPLICEOSOME",-0.39623,-1.22,0.194,5458,0.48,"DHX15, PRPF31, SRSF10, ALYREF, EFTUD2, SRSF5, PRPF4, PHF5A, HNRNPK, SF3B6, EIF4A3, U2AF2, TRA2A, LSM6, RBMX, NCBP1, PLRG1, SRSF4, SF3B4, SMNDC1, HSPA8, U2SURP, CDC5L, LSM8, SNRPG, MAGOHB, DHX16, RBM25, SF3A1, PPIH, U2AF1, CHERP, PRPF19, ISY1, RBM22, SF3A2, SF3B3, PRPF18, SF3B2, RBM8A, SYF2, ZMAT2, HNRNPC, SNRPC, BCAS2, CRNKL1, NCBP2, PRPF40A, SRSF1, TCERG1, PPIE, TRA2B, PPIL1, SNW1, SRSF3, CDC40, BUD31, LSM2, SLU7, TXNL4A, LSM7, SNRNP40, DDX5, RBM17, SRSF2, SNRNP27, HNRNPM, SRSF8, HNRNPU, SART1, WBP11, PQBP1, HNRNPA3, CCDC12, ACIN1, HNRNPA1, CWC15, LSM4, SNU13",0.712198270069774,0.318758762624413,FALSE +"H1650","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.31163,0.957,0.448,1077,0.651,"PGM1, SI, UGP2, GYS1",0.348721986001856,0.186419011431808,FALSE +"H1650","Input","KEGG_STEROID_BIOSYNTHESIS",0.47462,1.5,0.0598,759,0.344,"CEL, LIPA, DHCR24, SQLE, MSMO1",1.22329881601159,0.46344155742847,FALSE +"H1650","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.55675,-1.76,0.037,8521,0.314,"HSD11B2, AKR1D1, AKR1C2, AKR1C1, AKR1C3, HSD17B8",1.431798275933,0.503070351926785,FALSE +"H1650","Input","KEGG_SULFUR_METABOLISM",0.89874,2.82,0,196,0.00126,"SULT1A3, SULT2B1, PAPSS2, SULT1A1",Inf,2.89962945488244,TRUE +"H1650","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.47555,1.46,0.0859,1378,0.327,"CD40, C3, TRIM21, ACTN4",1.06600683616876,0.485452247339714,FALSE +"H1650","Input","KEGG_TASTE_TRANSDUCTION",0.70438,2.24,0.00186,2081,0.0775,"PRKACB, ADCY6, GNAS, ADCY8, PRKACA, CACNA1A",2.73048705578208,1.11069829749369,TRUE +"H1650","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.34493,1.05,0.362,2017,0.551,"MVK, MVD, HMGCR, ACAT2, HMGCS1",0.441291429466834,0.258848401148215,FALSE +"H1650","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.21329,-0.654,0.889,6297,0.931,"SP1, INHBE, AMH, RPS6KB2, SMURF2, ACVR1, CHRD, TGFB2, TGFB3, TGFBR1, TFDP1, SMAD5, MYC",0.0510982390297863,0.0310503190186574,FALSE +"H1650","Input","KEGG_THYROID_CANCER",-0.319,-0.95,0.484,8756,0.682,"TP53, MYC",0.315154638355588,0.166215625343521,FALSE +"H1650","Input","KEGG_TIGHT_JUNCTION",0.41238,1.27,0.179,1993,0.394,"CLDN6, EPB41L1, MYH14, MYH7B, CLDN4, MYH4, PRKCQ, RRAS, F11R, CTNNA1, CTNNB1, OCLN, PRKCD, PRKCZ, MAP3K20, CTNNA2, TJP3, PRKCI, PARD6B, LLGL2, PARD6G, MYH11, CGN, MYH9, CASK, AKT2, VAPA, ACTN4, AKT3, MYH3, PRKCE, TJP2, MAGI3, EXOC3, MYL9, PRKCA, AMOTL1, MYL12A, ACTG1, SRC, CDC42, EXOC4",0.747146969020107,0.404503778174426,FALSE +"H1650","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.45925,1.41,0.11,2235,0.348,"CD40, TRAF6, STAT1, CD14, CTSK, IRF3, MYD88, TICAM2, MAPK12, TLR9, MAPK3, MAP3K7, AKT2, AKT3, PIK3R3, MAPK14, CASP8, MAPK13, CHUK, TBK1, NFKB1, RAC1",0.958607314841775,0.458420756053419,FALSE +"H1650","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.34755,-1.1,0.282,8197,0.588,"HAAO, WARS2, ALDH2, ALDH1B1, MAOA, DDC",0.549750891680639,0.230622673923862,FALSE +"H1650","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29609,0.911,0.516,1750,0.693,"PRKCD, PRKCZ, ABCC8, PKLR, MAPK3, PIK3R3, PRKCE, MTOR, HK1",0.287350298372789,0.159266765388193,FALSE +"H1650","Input","KEGG_TYROSINE_METABOLISM",-0.61024,-1.88,0.0234,7263,1,"BUD23, METTL2B, ADH4, ADH7, TYRP1, GSTZ1, FAH, ALDH3A1, DCT, ADH1C, MAOA, DDC",1.63078414258986,0,FALSE +"H1650","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.3151,0.967,0.464,2728,0.647,"PPP3R2, NFAT5, PRKCQ, MALT1, PPP3R1, PPP3CA, PPP3CB, VAV2, MAPK12, MAPK3, MAP3K7, AKT2, AKT3, PIK3R3, SOS1, MAPK14, CBLB, MAPK13, CDC42, CHUK, NFKB1, FYN, HRAS, PAK5, PAK6, AKT1, CHP1, PAK4, PIK3CB, BCL10, RHOA, PTPN6",0.333482019445119,0.1890957193313,FALSE +"H1650","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.30281,0.925,0.501,1790,0.682,"UBE2L6, TRAF6, UBA7, FBXO2, KEAP1, WWP2, FBXO4, UBE3B, DDB2, HERC4, ITCH, WWP1, HUWE1, FZR1, SYVN1, NEDD4, MID1, SKP1, TRIM32, SKP2, CBLB",0.300162274132754,0.166215625343521,FALSE +"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.33149,1.04,0.357,5924,0.561,"BCAT2, IARS2, LARS2, BCAT1, PDHB, PDHA1, VARS2",0.447331783887807,0.251037138743839,FALSE +"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.30165,0.918,0.543,2929,0.688,"ABAT, ALDH7A1, ACAA1, HIBADH, ALDH3A2, BCAT2, OXCT1, ACAT2, HMGCS1, AUH, ACAD8, DLD, EHHADH, BCKDHB, MCCC2, HADH, HADHA, HADHB, ALDH9A1, ACADSB, MCCC1, MCEE",0.265200170411153,0.162411561764489,FALSE +"H1650","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.34902,1.06,0.359,1760,0.54,"KCNMA1, PRKCQ, PRKACB, ADCY6, ADCY5, PRKCD, ITPR2, GNAS, MYL6, MYH11, ADCY3, ADCY8, MAPK3, PRKCE, MYL9, PRKACA, PRKCA, PPP1R12B, GNAQ, ROCK1",0.444905551421681,0.267606240177031,FALSE +"H1650","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.50687,1.59,0.0444,2693,0.33,"PRKACB, ARHGDIB, ADCY6, RAB11A, GNAS, DYNC1LI2, ADCY3, RAB11B, DYNC1I2, DYNC1H1, PRKACA, STX4, RAB5B, RAB5C, DYNC2H1, DCTN1, RAB5A, VAMP2, DCTN4, DCTN6, DYNLL2",1.35261702988538,0.481486060122112,FALSE +"H1650","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.44319,1.37,0.125,2710,0.354,"HSPB1, PPP3R2, NFAT5, PPP3R1, PPP3CA, PPP3CB, PTK2, MAPKAPK3, MAPK12, MAPK3, AKT2, AKT3, PIK3R3, SPHK2, PXN, MAPK14, PRKCA, MAPK13, SRC, CDC42, SH2D2A, PLCG2, RAC1, HRAS, MAPKAPK2, AKT1, PLA2G12A, CHP1, PIK3CB",0.903089986991944,0.450996737974212,FALSE +"H1650","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.25989,0.798,0.709,2193,0.829,"PRKACB, ERO1A, KDELR3, TCIRG1, GNAS, ADCY3, TJP2, PRKACA, PRKCA, ATP6V1C2, ACTG1, PLCG2, ATP6V1C1",0.149353764816933,0.0814454694497265,FALSE +"H1650","Input","KEGG_VIRAL_MYOCARDITIS",0.46071,1.4,0.116,1185,0.343,"CD40, ITGB2, CAV1, MYH14, MYH7B, MYH4, CD55, DAG1, CXADR, MYH11, MYH9",0.935542010773082,0.464705879957229,FALSE +"H1650","Input","KEGG_WNT_SIGNALING_PATHWAY",0.28828,0.893,0.574,1803,0.713,"CAMK2G, PPP3R2, CAMK2B, NFAT5, FZD2, PPP3R1, PRKACB, FZD1, PPP3CA, CTNNB1, PPP3CB, CAMK2D, APC, PPP2R5E, SMAD3, MAP3K7, PORCN, CREBBP, SKP1, EP300, PRKACA, PRKCA, PPP2R5A, ROCK1, VANGL1",0.241088107602027,0.146910470148134,FALSE +"H1975","Input","KEGG_ABC_TRANSPORTERS",0.3515,1.06,0.354,1220,0.606,"ABCG2, ABCA3, TAP1, ABCB8, ABCA1",0.450996737974212,0.217527375833714,FALSE +"H1975","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.36108,1.1,0.307,2283,0.617,"MYC, AKT1, ARAF, MAP2K2, RAF1, PIK3R2, STAT5A, RPS6KB2, PIK3CA, IKBKG, MAPK1, CHUK, IKBKB, RUNX1, TCF7L1, NFKB1, BRAF",0.512861624522813,0.209714835966758,FALSE +"H1975","Input","KEGG_ADHERENS_JUNCTION",0.18147,0.552,0.983,2134,1,"RAC2, SORBS1, WASF1, ACTN3, FER, VCL, ACTN1, MAP3K7, FYN, MAPK1, SMAD4, TGFBR1, TCF7L1",0.00744648216786438,0,FALSE +"H1975","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.31622,-0.959,0.449,8785,0.678,"PCK2, RXRB, PRKAB1, ACSL6, CPT1A, SLC2A1, ADIPOR2, ADIPOR1, PRKAA2",0.347753658996677,0.168770306132937,FALSE +"H1975","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.39596,1.17,0.252,1268,0.583,"GFPT2, ADSL, ASL, ASNS, ASS1, CPS1",0.598599459218456,0.234331445240986,FALSE +"H1975","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.25709,0.774,0.747,2963,0.836,"PRKCA, PRKCB, PIK3R2, NR3C2, PIK3CA, MAPK1, IRS1, PDPK1, IRS2, SFN, NEDD4L, INSR",0.126679398184601,0.0777937225609836,FALSE +"H1975","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.62443,-1.95,0.0135,8351,0.24,"PLA2G12A, ACOX3, PLA2G2D, ACOX1, PLA2G4A, PLA2G2A",1.86966623150499,0.619788758288394,TRUE +"H1975","Input","KEGG_ALZHEIMERS_DISEASE",-0.22158,-0.686,0.876,7249,0.908,"APOE, UQCRQ, COX7A2, ATP5PO, NDUFA4, COX6B1, ADAM10, COX5B, BID, ATP5F1D, UQCRFS1, BAD, UQCRC2, COX5A, ATP5PF, NCSTN, COX7A2L, UQCRC1, NDUFA5, ATP5F1E, PLCB2, APP, CYC1, ATP5PD, ATP2A2, UQCRB, CASP7, PLCB4, SNCA, BACE2, MME, PLCB1",0.0574958938319193,0.0419141514789149,FALSE +"H1975","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.20376,0.619,0.928,7903,0.985,"LARS2, FARS2, HARS2, FARSB, FARSA, SEPSECS, CARS2, RARS2, TARS2, DARS2, MTFMT, YARS2, NARS2, VARS2, MARS2, PARS2, IARS2, EARS2, SARS2, WARS2, AARS2",0.0324520237811379,0.00656376950238827,FALSE +"H1975","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.42705,1.31,0.149,2528,0.629,"GFPT2, RENBP, UAP1, AMDHD2, GMPPA, UGDH, GMPPB, HK2, GNPDA1, GPI, NAGK, GNE, PGM2, CYB5R3, HK3, PGM3",0.826813731587726,0.201349354554731,FALSE +"H1975","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.48166,1.45,0.0884,505,0.698,"NEFH, PRPH, PRPH2, TP53, NEFM, CCS",1.05354773498693,0.156144577376839,FALSE +"H1975","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.15472,0.47,0.998,2208,0.997,"CD74, TAP1, LGMN, CTSB, CTSL, HSPA2",0.000869458712628891,0.00130484168834428,FALSE +"H1975","Input","KEGG_APOPTOSIS",0.47654,1.46,0.0996,2233,0.828,"TP53, IL1RAP, PRKACA, PRKAR1B, AKT1, CASP8, ENDOG, TRADD, PIK3R2, IRAK4, IRAK1, MYD88, TNFRSF10D, CAPN2, PIK3CA, IKBKG, PPP3CA, XIAP, CHUK, IKBKB, PRKAR1A, PPP3CB, IRAK2, PRKACB, PRKAR2A, FADD, ENDOD1, NFKB1",1.0017406615763,0.0819696632151199,FALSE +"H1975","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.40931,-1.27,0.191,8863,0.438,"PLA2G2D, TBXAS1, ALOX5, CYP2J2, CYP4F3, AKR1C3, PLA2G4A, PTGS2, PLA2G2A",0.718966632752272,0.3585258894959,FALSE +"H1975","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34722,1.05,0.387,1902,0.59,"NOS3, MAOB, ASL, ARG1, ASS1, GATM, CPS1, CKB, MAOA, SMS, OAT, GLS, GLS2",0.412289034981089,0.229147988357856,FALSE +"H1975","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.32182,-1,0.428,9580,0.669,"ITGA1, CACNA2D1, ITGB8, PKP2, CDH2, SGCD",0.368556230986828,0.174573882232177,FALSE +"H1975","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.32282,-0.978,0.458,7529,0.677,"ALDH7A1, ALDH3A2, ALDH2",0.339134521996131,0.169411331314856,FALSE +"H1975","Input","KEGG_AXON_GUIDANCE",0.42478,1.28,0.161,1781,0.613,"RAC2, ABLIM3, SEMA3B, PAK5, PAK6, SRGAP1, DPYSL2, LIMK1, RGS3, EPHB2, SEMA7A, RASA1, PLXNA3, GNAI2, EPHB4, ABLIM1, NRP1, ROBO1, SRGAP2, SRGAP3, SEMA4C, PAK1, FYN, PPP3CA, MAPK1",0.79317412396815,0.212539525481585,FALSE +"H1975","Input","KEGG_BASAL_CELL_CARCINOMA",0.41379,1.23,0.208,919,0.571,"FZD2, TP53, WNT5B, DVL1, DVL2",0.681936665037238,0.243363891754152,FALSE +"H1975","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.18977,0.572,0.972,8043,1,"STON1, TAF11, GTF2E2, GTF2IRD1, GTF2E1, TAF1, TAF7, GTF2F1, TAF4, GTF2H3, GTF2A2, GTF2H4, TAF6L, GTF2H2, TAF2, TAF6, TBPL1, GTF2F2, TBP, TAF5, TAF5L, GTF2A1, TAF9, TAF9B, TAF10, GTF2B, GTF2I, TAF12, GTF2H1",0.0123337350737254,0,FALSE +"H1975","Input","KEGG_BASE_EXCISION_REPAIR",-0.43785,-1.36,0.135,6637,0.434,"POLB, PCNA, PARP1, PARP2, MBD4, POLE3, MPG, XRCC1, LIG1, UNG, TDG, FEN1, POLD1, HMGB1, POLD3, MUTYH, POLE, POLD2, APEX2, POLE2",0.869666231504994,0.362510270487489,FALSE +"H1975","Input","KEGG_BETA_ALANINE_METABOLISM",-0.2739,-0.827,0.657,7467,0.822,"ACADM, ALDH7A1, HADHA, ABAT, ALDH3A2, HIBCH, ALDH2",0.182434630440219,0.0851281824599496,FALSE +"H1975","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.24323,0.738,0.792,1537,0.881,"ACOT4, HACD2, HACD1, ACAA1",0.101274818410506,0.0550240915879521,FALSE +"H1975","Input","KEGG_BLADDER_CANCER",0.33074,1.01,0.386,2283,0.598,"TP53, MYC, THBS1, ARAF, TYMP, MAP2K2, RAF1, CDKN1A, MAPK1, VEGFA, DAPK3, CDK4, BRAF",0.413412695328245,0.223298816011589,FALSE +"H1975","Input","KEGG_BUTANOATE_METABOLISM",-0.49108,-1.54,0.0706,7529,0.348,"ALDH7A1, HADH, HADHA, ACADS, OXCT1, ABAT, ALDH3A2, HMGCS1, L2HGDH, ACAT2, ALDH2, BDH1, ALDH5A1",1.1511952989482,0.458420756053419,FALSE +"H1975","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.37051,1.11,0.276,1904,0.609,"RAC2, CD79A, CARD11, CD81, VAV2, VAV1, AKT1, MALT1, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, PIK3CA, IKBKG, LYN, PPP3CA, MAPK1, CHUK, IKBKB, PPP3CB",0.559090917934782,0.215382707367125,FALSE +"H1975","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.40289,1.2,0.221,2506,0.575,"NOS3, TNNC1, MYLK, PRKACA, PRKCA, CACNA1A, F2R, ITPR1, GNA15, ADCY7, PHKA1, PRKCB, PLCG2, GNA11, PHKB, CACNA1F, PTK2B, ATP2B1, PPP3CA, PPP3CB, ATP2A3, PRKACB, PHKG2, ITPR3, ATP2B2, ATP2B4, PLCD1, PHKA2, GNAS, CAMK2G, GRIN1",0.655607726314889,0.24033215531037,FALSE +"H1975","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.31443,0.932,0.497,257,0.629,"MYH7, TNNC1, TPM4",0.303643611266668,0.201349354554731,FALSE +"H1975","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.327,0.984,0.417,1763,0.615,"VCAN, ICAM2, CD274, SDC4, ICAM1, CD40, CNTNAP1, CLDN4, CADM1, MPZ, CDH15, CDH3, PVR, CLDN16, CLDN6, SPN, CD276, CLDN3, SDC1, ALCAM",0.379863945026242,0.211124884224583,FALSE +"H1975","Input","KEGG_CELL_CYCLE",-0.37917,-1.15,0.278,7661,0.51,"ATR, ORC4, ANAPC7, ORC1, CDC25C, ORC2, CDC25B, CDC45, MCM2, MCM7, CDC26, RB1, RAD21, MCM4, MCM6, MCM3, ESPL1, DBF4, STAG1, TFDP2, PLK1, ORC3, ZBTB17, CDC7, E2F3, MAD2L1, TFDP1, MDM2, BUB1B, MAD2L2, CHEK1, TTK, BUB1, PTTG1, ORC6, TGFB1, CCNB2, WEE1, CDC20, SKP2, CCNA2, CDC14B",0.555955204081924,0.292429823902064,FALSE +"H1975","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.28638,0.86,0.611,2283,0.702,"RAC2, PRKACA, GNG10, VAV2, VAV1, AKT1, ADCY7, PRKCB, RAF1, PIK3R2, GNAI2, BCAR1, PRKCD, GNB4, PTK2B, GRK2, PIK3CA, IKBKG, PAK1, STAT2, LYN, GNG5, HCK, MAPK1, CHUK, IKBKB, FOXO3, PRKACB, ARRB1, NFKB1, CRK, BRAF",0.213958789757446,0.153662887870195,FALSE +"H1975","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.35431,1.09,0.315,2845,0.616,"TP53, MYC, AKT1, ARAF, MAP2K2, RAF1, PIK3R2, CDKN1B, STAT5A, BCR, CDKN1A, PIK3CA, IKBKG, MAPK1, CHUK, IKBKB, SMAD4, TGFBR1, CDK4, RUNX1, NFKB1, CRK, BRAF, CRKL, TGFB2, CBL, SOS2, CCND1",0.501689446210399,0.210419287835575,FALSE +"H1975","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.26691,-0.814,0.676,6745,0.814,"CLOCK, CSNK1E, BHLHE40",0.170053304058364,0.0893755951107988,FALSE +"H1975","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.34781,-1.09,0.327,6653,0.543,"MDH2, OGDH, OGDHL, IDH3G, SDHB, DLST, IDH3B, IDH3A, PCK2, DLAT, IDH2",0.485452247339714,0.265200170411153,FALSE +"H1975","Input","KEGG_COLORECTAL_CANCER",0.32619,0.981,0.423,2283,0.606,"RAC2, TP53, MYC, AKT1, ARAF, RAF1, PIK3R2, MAPK10, MAPK8, PIK3CA, APPL1, MAPK1, APC, SMAD4, TGFBR1, TCF7L1, BRAF",0.373659632624958,0.217527375833714,FALSE +"H1975","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.38026,1.13,0.305,868,0.601,"SERPINE1, PROS1, C4A, PLAU, F2R, TFPI, A2M, C3",0.515700160653214,0.22112552799726,FALSE +"H1975","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.38729,1.15,0.277,2745,0.586,"TAT, LDHA, CTH, SMS, LDHB, SDS, MPST, SRM, MTR, AHCY",0.557520230935551,0.232102383981909,FALSE +"H1975","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.31713,-0.955,0.473,8918,0.67,"IL1R1, TNFSF13B, LIF, TGFB1, IL6, TNFRSF21, INHBA, CXCR4, TNFRSF11B, CX3CL1, CXCL5, NGFR",0.325138859262188,0.173925197299174,FALSE +"H1975","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.25405,-0.783,0.743,9336,0.858,"TREX1, IL6, ZBP1",0.129011186239425,0.0665127121512946,FALSE +"H1975","Input","KEGG_DILATED_CARDIOMYOPATHY",0.40717,1.21,0.215,257,0.581,"MYH7, TNNC1, ITGB3, DES, PRKACA, ITGA5, TPM4",0.667561540084395,0.235823867609669,FALSE +"H1975","Input","KEGG_DNA_REPLICATION",-0.61634,-1.91,0.0182,7089,0.229,"RPA3, POLE3, MCM5, RNASEH2B, LIG1, RFC3, PRIM1, POLA1, MCM2, FEN1, POLD1, MCM7, POLD3, POLA2, RFC4, MCM4, MCM6, MCM3, POLE, POLD2, RNASEH2C, PRIM2, POLE2",1.73992861201493,0.640164517660112,TRUE +"H1975","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.15728,0.477,1,2797,1,"ETS1, MAPK1, SPIRE1, SOS2",0,0,FALSE +"H1975","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.47746,1.47,0.0871,895,0.866,"ALDH3B1, MAOB, GSTP1, GSTA5, GSTM2, CYP3A4, GSTZ1",1.05998184499234,0.0624821079826534,FALSE +"H1975","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.48953,1.51,0.0784,1671,0.905,"UPP1, CDA, IMPDH1, CYP3A4, TYMP, UCKL1, DPYD, IMPDH2",1.10568393731556,0.0433514207947967,FALSE +"H1975","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.41838,1.25,0.2,580,0.56,"FN1, COL5A1, TNC, ITGB3, COL1A2, ITGA5, THBS2, CD44, SDC4, COL6A1, THBS1, COL1A1",0.698970004336019,0.2518119729938,FALSE +"H1975","Input","KEGG_ENDOCYTOSIS",0.31138,0.939,0.494,3371,0.637,"EHD2, SH3KBP1, ASAP3, F2R, EPN1, CHMP2A, RAB31, ITCH, IQSEC2, SH3GL1, RABEP1, EHD4, PSD3, DNM2, SMURF1, ASAP2, PLD2, STAM, ARFGAP1, ARFGAP3, IQSEC1, RBSN, GRK2, RAB11FIP5, PDCD6IP, GIT2, RAB5B, DNM1, CHMP3, ACAP2, DNAJC6, VPS37A, DNM1L, VPS4A, SH3GLB1, HSPA2, ARRB1, EEA1, AGAP1, PSD4, CHMP2B, PSD, RAB5A, SMURF2, CBL, ASAP1, RAB11FIP1, RAB11FIP2, WWP1, TSG101, PLD1, NEDD4L, STAM2, RAB22A, VPS4B, RAB5C, RNF41, GIT1, TRAF6, VPS25, ARF6, EPN3, EHD3",0.306273051076353,0.19586056766465,FALSE +"H1975","Input","KEGG_ENDOMETRIAL_CANCER",0.41013,1.25,0.202,2283,0.56,"TP53, MYC, PTEN, AKT1, ARAF, MAP2K2, RAF1, PIK3R2, PIK3CA, ILK, MAPK1, FOXO3, APC, TCF7L1, PDPK1, BRAF",0.694648630553376,0.2518119729938,FALSE +"H1975","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.35618,1.06,0.336,3667,0.606,"PLCG2, MAPK10, MAPK8, MAP2K4, IKBKG, PAK1, LYN, CHUK, IKBKB, ATP6V1C1, NFKB1, ATP6V1G1, ATP6V1D, ATP6V1E1, ATP6V1B2, TCIRG1, MAPK14, ATP6V1B1, MAPK9, GIT1, ATP6V1H, PLCG1, RELA, CASP3, ATP6V1F, TJP1, ADAM17, ATP6V1A",0.473660722610156,0.217527375833714,FALSE +"H1975","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.41338,1.26,0.179,2804,0.584,"PAK5, PAK6, PRKCA, MYC, AKT1, ARAF, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, CDKN1B, STAT5A, MAPK10, RPS6KB2, MAPK8, CDKN1A, MAP2K4, PIK3CA, PAK1, MAPK1, CRK, BRAF, ABL2, PAK3, CRKL, CAMK2G, AREG, CBL, CAMK2D, SOS2, PAK2",0.747146969020107,0.233587152887601,FALSE +"H1975","Input","KEGG_ETHER_LIPID_METABOLISM",-0.30959,-0.943,0.471,8863,0.676,"PLA2G2D, PAFAH1B3, PLA2G4A, PLA2G2A",0.326979092871104,0.170053304058364,FALSE +"H1975","Input","KEGG_FATTY_ACID_METABOLISM",-0.31974,-0.988,0.44,7467,0.675,"ACADM, ALDH7A1, HADH, HADHA, ACADS, ECI1, ALDH3A2, ACAT2, ACOX3, ACSL6, CPT1A, ACOX1, ALDH2, ACADL, ADH1C",0.356547323513813,0.170696227168975,FALSE +"H1975","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.36516,1.09,0.315,1781,0.616,"RAC2, PLA2G6, PRKCA, VAV2, VAV1, AKT1, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, MAPK10, PRKCD, MAPK8, MAP2K4, PIK3CA, FYN, LYN, MAPK1",0.501689446210399,0.210419287835575,FALSE +"H1975","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.42379,1.27,0.165,2241,0.58,"RAC2, PLA2G6, PRKCA, ASAP3, LIMK1, WASF1, VAV2, VAV1, AKT1, PLPP2, MYO10, DNM2, PRKCB, PLCG2, RAF1, PIK3R2, ASAP2, PLD2, PLPP1, PRKCD, RPS6KB2, PIK3CA, PAK1, DNM1, LYN, HCK, MAPK1, DNM1L, MARCKS, ARPC4, ARPC5L, CRK, ARPC1A",0.782516055786094,0.236572006437063,FALSE +"H1975","Input","KEGG_FOCAL_ADHESION",0.44046,1.31,0.152,1658,0.629,"FN1, COL5A1, TNC, ITGB3, RAC2, CAV2, MYLK, CAV1, PAK5, PAK6, PRKCA, COL1A2, ITGA5, THBS2, FLNA, MYL9, COL6A1, THBS1, ZYX, PARVA, VAV2, VAV1, PTEN, AKT1, COL1A1, TLN2, FLNC, ACTN3, MYL12A, PRKCB, RAF1, PIK3R2, ARHGAP5, BCAR1, MAPK10, TLN1, MAPK8, VCL, CAPN2, ACTN1, PIK3CA, ITGA3, PAK1, ILK, FYN",0.818156412055227,0.201349354554731,FALSE +"H1975","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.35669,-1.1,0.296,7275,0.56,"ALPI, ALPP, ALPL, GGH, DHFR",0.528708288941061,0.2518119729938,FALSE +"H1975","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.52992,1.6,0.0531,2937,0.931,"AKR1B1, ALDOB, ALDOC, FBP2, FBP1, PFKFB4, MTMR1, GMPPA, MTMR6, GMPPB, HK2, PFKP, SORD, HK3, PFKM, PHPT1, ALDOA",1.27490547891853,0.0310503190186574,FALSE +"H1975","Input","KEGG_GALACTOSE_METABOLISM",0.31091,0.939,0.499,3748,0.637,"AKR1B1, HK2, B4GALT1, PFKP, PGM2, MGAM, HK3, PFKM, GAA, GLB1, GALK1, PFKL, UGP2, GALE",0.30189945437661,0.19586056766465,FALSE +"H1975","Input","KEGG_GAP_JUNCTION",0.35606,1.08,0.333,1189,0.614,"TUBA4A, PRKACA, PRKCA, GJA1, TUBB6, ITPR1, ADCY7, PRKCB, MAP2K2, RAF1, GNA11, GNAI2, TUBA3C",0.47755576649368,0.211831628858832,FALSE +"H1975","Input","KEGG_GLIOMA",0.39706,1.2,0.231,1471,0.575,"TP53, PRKCA, PTEN, AKT1, ARAF, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, CDKN1A, PIK3CA",0.636388020107856,0.24033215531037,FALSE +"H1975","Input","KEGG_GLUTATHIONE_METABOLISM",0.43351,1.28,0.162,1882,0.613,"ANPEP, GSTP1, GSTA5, GGT1, GSTM2, GPX4, GSS, GSTZ1, SMS, GGT7, RRM1, GPX3, G6PD",0.790484985457369,0.212539525481585,FALSE +"H1975","Input","KEGG_GLYCEROLIPID_METABOLISM",0.34322,1.03,0.348,1674,0.602,"AKR1B1, AGPAT4, MGLL, PLPP2, DGKA, PLPP1, CEL, DGKB, GPAT3, DGKQ, GPAM",0.458420756053419,0.220403508742175,FALSE +"H1975","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.31557,0.935,0.505,1674,0.638,"PLA2G6, AGPAT4, PLPP2, DGKA, PTDSS1, LPCAT1, MBOAT7, PLD2, PLPP1, DGKB, CHKB, GPAT3, CDS2, DGKQ, CHKA, GPAM",0.296708621881339,0.195179321278838,FALSE +"H1975","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.57847,1.72,0.029,1465,1,"SARDH, MAOB, SHMT1, SRR, CTH, GATM, MAOA, PSAT1",1.53760200210104,0,FALSE +"H1975","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.32299,0.998,0.436,2937,0.612,"ALDH3B1, ALDOB, LDHA, ALDOC, GALM, PGK2, FBP2, ACSS1, FBP1, PGAM1, PGAM4, PGK1, PKM, LDHB, HK2, GPI, PFKP, PGM2, HK3, ALDH9A1, PFKM, ENO2, PKLR, ALDH1B1, ALDOA",0.360513510731414,0.213248577854439,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.42066,-1.25,0.204,8932,0.433,"CHSY3, XYLT1",0.690369832574101,0.363512103646635,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.46541,-1.4,0.113,7497,0.426,"HS2ST1, GLCE, EXTL2, XYLT1",0.94692155651658,0.370590400897281,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.3595,-1.11,0.292,9017,0.56,"B4GAT1, B4GALT4, B3GNT2",0.534617148551582,0.2518119729938,FALSE +"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.23143,-0.702,0.847,7944,0.917,"HPSE, ARSB, GUSB, HEXA",0.0721165896692931,0.0376306643299789,FALSE +"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.28895,0.871,0.583,4039,0.696,"B4GALNT1, ST3GAL2, GLB1, HEXB, SLC33A1, ST3GAL1",0.234331445240986,0.157390760389438,FALSE +"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.3233,0.986,0.428,526,0.618,"B3GALT5",0.368556230986828,0.209011524911184,FALSE +"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.42236,-1.28,0.175,7885,0.441,"B4GALT3, B3GNT3, B4GAT1, ST3GAL4, B4GALT4, B3GNT2",0.756961951313706,0.355561410532161,FALSE +"H1975","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.14942,-0.448,1,6278,0.998,"PIGU, PIGS, PIGX, PIGT, GPAA1, PIGK, PIGO",0,0.000869458712628891,FALSE +"H1975","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.309,0.943,0.482,2512,0.644,"MTHFD1, HYI, PGP",0.31695296176115,0.191114132640188,FALSE +"H1975","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.25085,0.761,0.768,1424,0.851,"PLA2G6, PRKACA, PRKCA, ITPR1, ADCY7, PRKCB, MAP2K2, MMP14, RAF1, GNA11, PLD2, MAPK10, PRKCD, MAPK8, CACNA1F, MAP2K4, PTK2B",0.114638779968488,0.0700704399154121,FALSE +"H1975","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.36442,1.12,0.308,1117,0.599,"PRKACA, WNT5B, FBXW11",0.511449283499556,0.222573177610689,FALSE +"H1975","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.4457,1.34,0.137,286,0.685,"ANPEP, ITGB3, ITGA5, CD44, CSF1",0.863279432843593,0.164309428507574,FALSE +"H1975","Input","KEGG_HISTIDINE_METABOLISM",0.38017,1.16,0.261,1308,0.59,"ALDH3B1, MAOB, HNMT, TRMT11, MAOA",0.583359492661719,0.229147988357856,FALSE +"H1975","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.5707,-1.76,0.0292,7933,0.296,"BRCA2, POLD1, POLD3, EME1, RAD52, POLD2, MUS81, RAD54B, MRE11, BLM, RAD51",1.53461714855158,0.528708288941061,FALSE +"H1975","Input","KEGG_HUNTINGTONS_DISEASE",-0.15189,-0.462,1,6482,1,"TBP, POLR2J, SOD1, BBC3, SIN3A, COX7B, CASP9, ATP5PB, ATP5F1C, UQCRH, VDAC1, NDUFB10, POLR2G, ATP5F1B, CREB1, SDHB, SP1, UQCRQ, HDAC2, COX7A2, ATP5PO, NDUFA4, POLR2D, COX6B1, RCOR1, SLC25A5, GRM5, COX5B, VDAC3, POLR2K, ATP5F1D, POLR2E, POLR2L, UQCRFS1, UQCRC2, POLR2C, COX5A, ATP5PF, COX7A2L, UQCRC1, NDUFA5, ATP5F1E, PLCB2, CYC1, ATP5PD, SLC25A4, POLR2I, SOD2, UQCRB, REST, POLR2F, PLCB4, PLCB1",0,0,FALSE +"H1975","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.3829,1.17,0.237,468,0.583,"MYH7, TNNC1, ITGB3, DES, ITGA5, PRKAB2, TPM4, ACE",0.625251653989896,0.234331445240986,FALSE +"H1975","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.23182,-0.692,0.841,8770,0.916,"ITPK1, ISYNA1, INPP1, PLCB4, INPP5B, PLCB1, ITPKA",0.0752040042020878,0.0381045263321496,FALSE +"H1975","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.39026,1.15,0.253,2488,0.586,"PYGL, PYGB, PRKACA, PRKAB2, SORBS1, PRKAR1B, AKT1, ARAF, PHKA1, PRKAG2, TRIP10, MAP2K2, FBP2, EIF4E2, RAF1, FBP1, PIK3R2, PHKB, MAPK10, RPS6KB2, MAPK8, RHEB, PIK3CA, ACACA, TSC1, TSC2, EXOC7, ACACB, MAPK1, IRS1, IKBKB, HK2, PRKAR1A, PRKACB, RAPGEF1, PRKAR2A, PDPK1, PHKG2, CRK, BRAF, PHKA2, IRS2, HK3, CRKL",0.596879478824182,0.232102383981909,FALSE +"H1975","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.63372,-1.95,0.0127,9030,0.24,"TNFSF13B, TGFB1, IL6, CXCR4",1.89619627904404,0.619788758288394,TRUE +"H1975","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.20607,0.627,0.951,1618,0.987,"MYC, STAT6, AKT1, OSMR, TYK2, PIK3R2, STAT5A, STAM, PIK3CA, LIFR, STAT2",0.0218194830625861,0.00568284733036327,FALSE +"H1975","Input","KEGG_LEISHMANIA_INFECTION",-0.23201,-0.717,0.823,8989,0.91,"TLR2, TGFB1, PTGS2, FOS",0.0846001647877302,0.0409586076789064,FALSE +"H1975","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.39867,1.18,0.229,1471,0.588,"RAC2, PRKCA, MSN, MYL9, ICAM1, VAV2, VAV1, CYBA, CLDN4, ACTN3, MYL12A, PRKCB, PLCG2, PIK3R2, ARHGAP5, GNAI2, BCAR1, CLDN16, CLDN6, VCL, ACTN1, PTK2B, PIK3CA",0.640164517660112,0.230622673923862,FALSE +"H1975","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.40122,-1.25,0.191,7529,0.433,"ALDH7A1, HADHA, ALDH3A2, YOD1, ALDH2",0.718966632752272,0.363512103646635,FALSE +"H1975","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.51809,-1.61,0.0467,8351,0.328,"PLA2G12A, PLA2G2D, CYP2J2, PLA2G4A, PLA2G2A",1.33068311943389,0.484126156288321,FALSE +"H1975","Input","KEGG_LONG_TERM_DEPRESSION",0.35499,1.07,0.321,1076,0.624,"PLA2G6, PRKCA, CACNA1A, ITPR1, ARAF, GNA13, PRKCB, MAP2K2, RAF1, GNA11, GNA12, GNAI2",0.493494967595128,0.204815410317576,FALSE +"H1975","Input","KEGG_LONG_TERM_POTENTIATION",0.42164,1.25,0.181,932,0.56,"PRKACA, PRKCA, RPS6KA6, ITPR1, RPS6KA3, RPS6KA2, ARAF, PRKCB, MAP2K2, RAF1",0.742321425130815,0.2518119729938,FALSE +"H1975","Input","KEGG_LYSINE_DEGRADATION",-0.48523,-1.47,0.0952,7368,0.381,"SETD1A, DLST, ASH1L, ALDH7A1, HADH, HADHA, SETD1B, DOT1L, EHMT1, ALDH3A2, EHMT2, ACAT2, SETDB2, NSD3, SUV39H2, SETDB1, AADAT, NSD1, KMT5A, ALDH2, SUV39H1, NSD2, AASS, BBOX1, TMLHE",1.02136305161553,0.419075024324381,FALSE +"H1975","Input","KEGG_LYSOSOME",0.32882,0.983,0.446,2438,0.609,"ACP5, GALC, AP3S1, CTSF, AP3D1, AP3M2, AP1M2, IGF2R, AP3B1, IDS, LIPA, AP1S2, AP3M1, CTSA, AP1M1, LGMN, AP1S3, CTSB, LAMP2, CD63, NPC2, NAGPA, CTSL, AP1S1, AP1B1, AP4E1, SMPD1, LAMP3, AP1G1, GALNS, GGA1, AP4B1",0.350665141287858,0.215382707367125,FALSE +"H1975","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.29461,0.868,0.582,2237,0.695,"RAC2, TP53, PLA2G6, PRKACA, PRKCA, MOS, CACNA1A, FLNA, RPS6KA6, RAPGEF2, RPS6KA3, MYC, HSPB1, RPS6KA2, AKT1, RASA1, PPM1B, FLNC, RRAS2, PTPN7, PRKCB, MAP2K2, DUSP9, RAF1, MAPT, GNA12, MAPKAPK3, TAB1, MAPK10, MAPK8, CACNA1F, MAP2K4, CD14, MAP3K7, IKBKG, MAP4K3, PAK1, MAPK7, PPP3CA, PPM1A, MAPK1, MAP3K5, CHUK, IKBKB, MAP3K4, PPP3CB, TAB2, PRKACB, TGFBR1, MAPK8IP3, HSPA2, ARRB1, NFKB1, CRK, TAOK3",0.235077015350112,0.158015195409886,FALSE +"H1975","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.72945,-2.22,0.00935,8319,0.258,"HES1, PDX1, HNF1A, HNF4A, PAX6",2.02918838912748,0.58838029403677,FALSE +"H1975","Input","KEGG_MELANOGENESIS",0.34859,1.05,0.346,1076,0.59,"FZD2, PRKACA, PRKCA, MITF, WNT5B, ADCY7, DVL1, PRKCB, MAP2K2, DVL2, RAF1, GNAI2",0.460923901207223,0.229147988357856,FALSE +"H1975","Input","KEGG_MELANOMA",-0.33141,-1.04,0.33,9908,0.613,"FGF13, FGF2",0.481486060122112,0.212539525481585,FALSE +"H1975","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.38893,1.19,0.237,895,0.581,"ALDH3B1, GSTP1, GSTA5, CYP1B1, GSTM2, CYP3A4, GSTZ1",0.625251653989896,0.235823867609669,FALSE +"H1975","Input","KEGG_MISMATCH_REPAIR",-0.37846,-1.15,0.266,6634,0.51,"RFC2, PCNA, MSH3, RPA3, MSH6, MSH2, LIG1, RFC3, POLD1, POLD3, RFC4, POLD2, EXO1",0.575118363368933,0.292429823902064,FALSE +"H1975","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.45627,1.39,0.116,2440,0.688,"RPS6KA6, RPS6KA3, RPS6KA2, AKT1, CAB39, EIF4E2, PIK3R2, RICTOR, STRADA, RPS6KB2, RHEB, PIK3CA, TSC1, TSC2, MAPK1, EIF4B, VEGFA, PDPK1, BRAF, ULK1",0.935542010773082,0.162411561764489,FALSE +"H1975","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.52797,1.63,0.0455,1904,0.974,"ICAM2, RAC2, PRKCA, ICAM1, MICA, VAV2, VAV1, ARAF, ULBP1, RAET1L, ULBP2, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, PRF1, TNFRSF10D, PTK2B, PIK3CA, PAK1, FYN, PPP3CA, MAPK1, ULBP3, PPP3CB",1.34198860334289,0.0114410431213845,FALSE +"H1975","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.4103,1.24,0.204,818,0.565,"F2R, F2RL1, NR3C1",0.690369832574101,0.247951552180562,FALSE +"H1975","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.34476,1.04,0.366,2495,0.601,"TP53, RPS6KA6, RPS6KA3, RPS6KA2, RIPK2, AKT1, MAP2K2, PLCG2, RAF1, PIK3R2, YWHAH, IRAK4, MAPK10, PRKCD, IRAK1, MAPK8, PIK3CA, MAPK7, MAGED1, MAPK1, IRS1, MAP3K5, IKBKB, FOXO3, IRAK2, RAPGEF1, PDPK1, NFKB1, CRK, BRAF, IRS2, CRKL, CAMK2G",0.436518914605589,0.22112552799726,FALSE +"H1975","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.4539,1.39,0.112,1122,0.688,"NNMT, NAMPT, ENPP1, NT5C2, NT5E",0.950781977329818,0.162411561764489,FALSE +"H1975","Input","KEGG_NITROGEN_METABOLISM",0.34057,1.02,0.384,1268,0.588,"CA12, CA9, ASNS, CTH, CPS1",0.415668775632469,0.230622673923862,FALSE +"H1975","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.49777,1.47,0.0869,2233,0.866,"TRIP6, RIPK2, CASP8, PYDC1, TAB1, MAPK10, MAPK8, ERBIN, TAB3, MAP3K7, IKBKG, XIAP, MAPK1, CHUK, IKBKB, TAB2, NFKB1",1.06098022355133,0.0624821079826534,FALSE +"H1975","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.45163,-1.39,0.122,8146,0.416,"FEN1, LIG4, MRE11",0.913640169325252,0.380906669373257,FALSE +"H1975","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.30867,0.934,0.494,949,0.633,"TP53, PRKCA, AKT1, ARAF, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2",0.306273051076353,0.198596289982645,FALSE +"H1975","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.22824,0.686,0.88,1347,0.944,"DVL1, DVL2, DTX3L, JAG1",0.0555173278498314,0.025028005701931,FALSE +"H1975","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.37218,-1.16,0.258,7879,0.529,"LIG1, RFC3, GTF2H1, POLD1, CUL4A, POLD3, RFC4, POLE, POLD2, ERCC1, POLE2, GTF2H5, DDB2",0.58838029403677,0.276544327964814,FALSE +"H1975","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.25682,-0.78,0.724,7008,0.847,"DPAGT1, GANAB, ALG9, MOGS, MAN1A2, B4GALT3, ALG8, MAN2A2, ALG6, MGAT5, ALG5, ALG13, ALG14, MGAT4A",0.140261433802853,0.0721165896692931,FALSE +"H1975","Input","KEGG_OLFACTORY_TRANSDUCTION",0.35894,1.06,0.367,2730,0.606,"PRKACA, PRKACB, CAMK2G, CAMK2D",0.435333935747911,0.217527375833714,FALSE +"H1975","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.44693,-1.34,0.147,9163,0.418,"DHFR, TYMS, ALDH1L1",0.832682665251824,0.378823718224965,FALSE +"H1975","Input","KEGG_OOCYTE_MEIOSIS",0.22653,0.688,0.858,1904,0.95,"PRKACA, MOS, RPS6KA6, ITPR1, RPS6KA3, SMC1B, RPS6KA2, AR, ADCY7, YWHAH, FBXW11, PPP2R5E, PPP2R5B, SLK, PPP3CA, MAPK1, PPP2CB, PPP3CB",0.0665127121512946,0.0222763947111523,FALSE +"H1975","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.43007,-1.32,0.162,7313,0.425,"GBA, MAN2B2, MANBA, HEXA, FUCA1",0.790484985457369,0.371611069949688,FALSE +"H1975","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.17496,-0.547,0.979,6631,1,"COX7B, ATP5ME, ATP5PB, ATP5F1C, UQCRH, ATP5MG, NDUFB10, ATP5F1B, COX11, SDHB, UQCRQ, COX7A2, ATP5PO, NDUFA4, COX6B1, COX5B, ATP5F1D, UQCRFS1, UQCRC2, ATP12A, COX5A, ATP5PF, COX7A2L, UQCRC1, NDUFA5, ATP5F1E, CYC1, ATP5PD, UQCRB, PPA2",0.00921730819686218,0,FALSE +"H1975","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.2724,0.805,0.699,1894,0.794,"GALNT12, GALNT6, GALNT13, GALNT7, GALNT10, GALNT16, GALNT17",0.155522824254319,0.100179497572904,FALSE +"H1975","Input","KEGG_P53_SIGNALING_PATHWAY",0.32705,0.961,0.476,586,0.619,"SERPINE1, TP53, STEAP3, THBS1, TP53I3, PTEN, CASP8",0.322393047279507,0.208309350979882,FALSE +"H1975","Input","KEGG_PANCREATIC_CANCER",0.34523,1.03,0.378,2364,0.602,"RAC2, TP53, AKT1, RALB, ARAF, RAF1, PIK3R2, MAPK10, MAPK8, PIK3CA, RALA, IKBKG, MAPK1, CHUK, IKBKB, VEGFA, SMAD4, TGFBR1, CDK4, NFKB1, BRAF, RALBP1",0.422508200162775,0.220403508742175,FALSE +"H1975","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.35781,1.08,0.332,2175,0.614,"ENPP1, PANK2, DPYD, PANK1",0.478861916295964,0.211831628858832,FALSE +"H1975","Input","KEGG_PARKINSONS_DISEASE",-0.27786,-0.871,0.561,6631,0.75,"COX7B, CASP9, ATP5PB, ATP5F1C, UQCRH, VDAC1, NDUFB10, UBE2J1, ATP5F1B, SDHB, UQCRQ, COX7A2, ATP5PO, NDUFA4, COX6B1, SLC25A5, COX5B, VDAC3, ATP5F1D, UQCRFS1, UQCRC2, COX5A, HTRA2, ATP5PF, COX7A2L, PARK7, UQCRC1, NDUFA5, ATP5F1E, CYC1, ATP5PD, SLC25A4, UBE2J2, UQCRB, UBE2G2, UCHL1, SNCA",0.251037138743839,0.1249387366083,FALSE +"H1975","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.34842,1.05,0.363,3542,0.59,"LY96, TUBA4A, PRKCA, TUBB6, TUBA3C, CD14, FYN, ARHGEF2, ARPC4, ARPC5L, CTTN, TUBB4B, ARPC1A, ARPC2, TUBA1C, TUBB3, TUBB1, CTNNB1, CDH1, ROCK2, ARPC3, ARPC1B, YWHAQ, ABL1, ARPC5, TUBA1B",0.440093374963888,0.229147988357856,FALSE +"H1975","Input","KEGG_PATHWAYS_IN_CANCER",-0.31115,-0.959,0.449,9314,0.678,"TGFB1, AXIN2, LAMA5, IL6, SLC2A1, COL4A1, RET, WNT10A, RASSF5, TGFA, RAD51, MMP1, FZD1, SKP2, CEBPA, PML, BIRC5, FGFR2, PTGS2, FOS, LAMB4, LAMB1, MMP2, COL4A2, FGF13, FGF2",0.347753658996677,0.168770306132937,FALSE +"H1975","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.44533,1.34,0.139,2209,0.685,"AKR1B1, XYLB, UGDH, CRYL1",0.856985199745905,0.164309428507574,FALSE +"H1975","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.55606,1.7,0.0274,2962,0.881,"ALDOB, RBKS, ALDOC, FBP2, FBP1, PGLS, PRPS1, PRPS1L1, GPI, G6PD, PFKP, PGM2, PFKM, PRPS2, ALDOA, DERA",1.56224943717961,0.0550240915879521,FALSE +"H1975","Input","KEGG_PEROXISOME",-0.29213,-0.916,0.521,8264,0.711,"PEX11A, PRDX5, ACOX3, PHYH, SOD2, ABCD3, PEX2, ACSL6, ACOX1, PEX14, HSD17B4, SLC27A2, IDH2, NUDT19, ECH1",0.283162276700476,0.148130399270234,FALSE +"H1975","Input","KEGG_PHENYLALANINE_METABOLISM",0.60139,1.82,0.0251,375,0.894,"ALDH3B1, MAOB, TAT, MIF",1.60032627851896,0.0486624812040823,FALSE +"H1975","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.3277,0.994,0.451,2600,0.612,"PRKCA, ITPR1, IMPA2, PIP4K2A, PTEN, PIP4K2C, DGKA, SYNJ2, PRKCB, PLCG2, PIK3R2, PI4KA, DGKB, CDS2, PIK3CA, DGKQ, INPP4A, INPP5E, INPP5A, ITPR3, PLCD1, CDIPT, PI4KB, PIK3C3, INPPL1, INPP5K",0.345823458122039,0.213248577854439,FALSE +"H1975","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.25598,-0.776,0.727,7977,0.839,"UROS, FECH, GUSB, MMAB, BLVRB, CP",0.138465589140962,0.0762380391712997,FALSE +"H1975","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.33577,1.02,0.39,574,0.588,"CYP27A1, ANGPTL4, PLTP, ACSL4, SORBS1, ME1, PPARG",0.408935392973501,0.230622673923862,FALSE +"H1975","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.46509,1.39,0.115,24,0.688,"CYP27A1",0.939302159646388,0.162411561764489,FALSE +"H1975","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.44325,1.33,0.135,653,0.654,"CD79A, CD40, ADA, TAP1",0.869666231504994,0.184422251675733,FALSE +"H1975","Input","KEGG_PRION_DISEASES",-0.28228,-0.875,0.568,9350,0.758,"IL6, NCAM1, C9",0.245651664288981,0.120330794367946,FALSE +"H1975","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.29922,0.916,0.508,1471,0.643,"PRKACA, MOS, RPS6KA6, RPS6KA3, RPS6KA2, AKT1, ARAF, ADCY7, RAF1, PIK3R2, GNAI2, MAPK10, MAPK8, PIK3CA",0.294136287716081,0.191789027075778,FALSE +"H1975","Input","KEGG_PROPANOATE_METABOLISM",-0.27114,-0.825,0.666,7467,0.809,"ACADM, ALDH6A1, ALDH7A1, HADHA, ABAT, ALDH3A2, ACAT2, HIBCH, ACSS3, ALDH2, MCEE",0.176525770829699,0.0920514783877277,FALSE +"H1975","Input","KEGG_PROSTATE_CANCER",0.30764,0.922,0.508,2391,0.639,"GSTP1, TP53, PTEN, AKT1, ARAF, AR, MAP2K2, RAF1, PIK3R2, CDKN1B, CREB5, CDKN1A, PIK3CA, IKBKG, MAPK1, CHUK, IKBKB, TCF7L1, PDPK1, NFKB1, BRAF, CCNE1",0.294136287716081,0.1944991418416,FALSE +"H1975","Input","KEGG_PROTEASOME",0.33695,1.02,0.373,3414,0.588,"PSMB9, PSMB10, PSMF1, SEM1, PSMB8, PSME4, PSMB4, PSMD14, PSMD11, PSMD3, PSMD7, PSMD6, PSMD12, PSMD13",0.428291168191312,0.230622673923862,FALSE +"H1975","Input","KEGG_PROTEIN_EXPORT",-0.54391,-1.69,0.0451,7537,0.302,"HSPA5, SEC61A2, SRPRA, SPCS3, SEC11A, SPCS2, SRPRB, IMMP2L, SRP14, SPCS1, SRP9",1.34582345812204,0.519993057042849,FALSE +"H1975","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.58648,-1.8,0.0242,7805,0.3,"ATP1A4, ATP1A1, ATP1A3, PCK2, SLC4A4, ATP1B1, CA2, GLUD2",1.61618463401957,0.522878745280338,FALSE +"H1975","Input","KEGG_PURINE_METABOLISM",0.26498,0.785,0.732,1198,0.824,"PDE5A, PDE4A, PDE4D, PAPSS2, ADSL, NME7, PFAS, ENPP1, AMPD3, ADA, ENTPD3, NT5C2, IMPDH1, AMPD1, ADCY7, ADK, NT5E, NME4, GMPR",0.135488918941608,0.0840727883028842,FALSE +"H1975","Input","KEGG_PYRIMIDINE_METABOLISM",0.21891,0.673,0.9,1128,0.952,"UPP1, CDA, NME7, ENTPD3, NT5C2, TYMP, NT5E, NME4",0.0457574905606751,0.0213630516155257,FALSE +"H1975","Input","KEGG_PYRUVATE_METABOLISM",0.29567,0.906,0.539,1756,0.654,"AKR1B1, ME1, LDHA, HAGHL, ACSS1, ACACA, PKM, LDHB, ACACB",0.268411234813261,0.184422251675733,FALSE +"H1975","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.36929,1.12,0.274,1675,0.599,"FN1, ITGB3, RAC2, MYLK, PAK5, PAK6, ITGA5, MOS, MSN, MYL9, DIAPH2, MYH9, LIMK1, F2R, WASF1, VAV2, PIP4K2A, VAV1, ARAF, ENAH, PIP4K2C, ACTN3, GNA13, RRAS2, MYL12A, MYH10, MAP2K2, RAF1, PIK3R2, GNA12, SSH3, BCAR1, VCL, ACTN1, CD14, PIK3CA, ITGA3, PAK1, ARHGEF4, SSH2",0.562249437179612,0.222573177610689,FALSE +"H1975","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.38118,-1.16,0.268,9894,0.529,"PRKAA2",0.571865205971211,0.276544327964814,FALSE +"H1975","Input","KEGG_RENAL_CELL_CARCINOMA",0.33092,0.98,0.437,3029,0.6,"PAK5, PAK6, AKT1, ARAF, ETS1, MAP2K2, RAF1, PIK3R2, FLCN, PIK3CA, PAK1, MAPK1, VEGFA, RAPGEF1, CRK, BRAF, PAK3, CRKL, TGFB2, SOS2, PAK2, VHL, EGLN1",0.359518563029578,0.221848749616356,FALSE +"H1975","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.67973,2.04,0.00546,518,0.433,"ANPEP, CPA3, ACE, THOP1",2.26280735729526,0.363512103646635,FALSE +"H1975","Input","KEGG_RETINOL_METABOLISM",-0.65655,-2.01,0.0137,8808,0.368,"DHRS3, RDH10, DGAT1, ADH1C, DHRS9, ALDH1A1",1.86327943284359,0.434152181326482,FALSE +"H1975","Input","KEGG_RIBOFLAVIN_METABOLISM",0.69332,2.06,0.00852,1404,0.768,"ACP5, ENPP1, MTMR1, MTMR6",2.0695604052333,0.114638779968488,FALSE +"H1975","Input","KEGG_RIBOSOME",0.42905,1.31,0.146,4061,0.629,"RPS25, RPL37, RPL22L1, RPL29, RPS10, FAU, RPS7, RPS15, RPL27, RPS16, RPS26, RPS15A, RPL4, RPL37A, RPL21, RPS24, RPS8, RPL24, RSL24D1, RPL28, RPS9, RPL35A, RPS13, RPL14, UBA52, RPL35, RPL30, RPS21, RPL10, RPL36, RPS11, RPS5, RPS19, RPL8, RPL9, RPL3, RPL32, RPS3A, RPS3, RPL18A, RPL6, RPS18, RPL31, RPL26, RPS2, RPS20, RPS4X, RPL13A, RPL12, RPL5, RPL22, RPS23, RPL34, RPS28, RPL18, RPL15, RPLP0, RPL17, RPL11, RPL36A, RPL36AL, RPL23A, RPS27L, RPL7A, RPL7, RPL10A",0.835647144215563,0.201349354554731,FALSE +"H1975","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.48878,1.45,0.1,3047,0.698,"TBKBP1, CASP8, DHX58, TRADD, DDX58, IFIH1, MAPK10, ISG15, MAPK8, TRIM25, IRF7, MAVS, MAP3K7, IKBKG, OTUD5, ATG12, CHUK, IKBKB, FADD, NFKB1, RIPK1, TRAF3, MAPK14, CASP10, MAPK9, ATG5",1,0.156144577376839,FALSE +"H1975","Input","KEGG_RNA_DEGRADATION",0.1707,0.514,0.996,7870,1,"EDC3, TTC37, PATL1, SKIV2L, PAPOLA, EDC4, CNOT4, XRN1, ZCCHC7, C1D, ENO2, DCP1A, MPHOSPH6, CNOT1, DCP1B, CNOT7, DDX6, ENO1, CNOT9, CNOT3, PARN, CNOT10, EXOSC7, EXOSC10, CNOT2, XRN2, MTREX, LSM1, DIS3, CNOT6L, HSPD1, HSPA9, LSM7, EXOSC3, CNOT6, WDR61, EXOSC2, CNOT8, EXOSC4, TENT4A, PAPOLG, LSM2, LSM6, LSM4, EXOSC1, EXOSC9, EXOSC5, EXOSC6, DCPS, ENO3, EXOSC8, LSM8, DCP2, LSM3",0.00174066157630127,0,FALSE +"H1975","Input","KEGG_RNA_POLYMERASE",-0.51817,-1.58,0.0733,5450,0.333,"POLR1A, POLR2H, POLR3G, POLR3H, POLR3C, POLR3GL, POLR2B, POLR1B, POLR3K, POLR2J, POLR3F, POLR2G, POLR2D, POLR1C, POLR1D, POLR2K, POLR2E, POLR2L, POLR2C, POLR1E, POLR2I, POLR2F",1.13489602535887,0.47755576649368,FALSE +"H1975","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.50335,1.55,0.0632,1497,0.98,"GGT1, PAPSS2, CTH, TRMT11, SCLY, GGT7",1.19928292171761,0.00877392430750515,FALSE +"H1975","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.35355,-1.09,0.29,8221,0.543,"PIK3R1, COL4A6, RB1, CKS1B, TRAF4, PIAS1, ITGA6, RXRB, E2F3, BCL2L1, LAMA5, COL4A1, SKP2, PTGS2, FHIT, LAMB4, LAMB1, COL4A2",0.537602002101044,0.265200170411153,FALSE +"H1975","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.30308,0.892,0.549,2934,0.666,"STX2, STX8, STX10, YKT6, VTI1B, SNAP29, STX3, BET1, VTI1A, STX4, VAMP7, STX12, USE1",0.260427655549908,0.176525770829699,FALSE +"H1975","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.28537,-0.892,0.531,9899,0.74,"SMPD3",0.274905478918531,0.130768280269024,FALSE +"H1975","Input","KEGG_SPLICEOSOME",-0.48324,-1.45,0.107,5796,0.383,"SRSF6, CDC5L, SNRPD3, PPIL1, SRSF5, BUD31, SNRPE, PCBP1, SF3B1, PRPF8, EIF4A3, RBMX, DDX46, U2SURP, CRNKL1, LSM7, EFTUD2, HNRNPK, DDX5, RBM17, SRSF10, PRPF6, SRSF8, XAB2, SNRPB, CDC40, SF3A2, SNRNP200, HSPA8, SF3A1, SRSF2, LSM2, U2AF1, LSM6, DHX8, SNRNP70, SART1, LSM4, DDX42, TCERG1, DDX39B, SRSF7, TXNL4A, ACIN1, SRSF1, AQR, ALYREF, PQBP1, ISY1, DHX15, TRA2B, CCDC12, USP39, PRPF19, U2AF2, SF3B3, SF3B5, PRPF40B, SNRPG, SF3B4, WBP11, SF3B2, LSM8, MAGOHB, LSM3, PPIH, ZMAT2, PHF5A, SF3A3, BCAS2, HNRNPA1, SNRNP40, PRPF18, PRPF38A, THOC3, RBM8A, PPIE, SNU13, CWC15, HNRNPC, SNRPC, SNRNP27, SYF2, DDX23, HSPA1L, PUF60, SLU7, SNRPF, TRA2A, SRSF3, HNRNPA3, SRSF4, PRPF38B, SRSF9",0.97061622231479,0.416801226031377,FALSE +"H1975","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.50195,1.51,0.0617,2472,0.905,"PGM2L1, PYGL, PYGB, ENPP1, GBE1, UGDH, HK2, GPI, PGM2, MGAM, HK3",1.20971483596676,0.0433514207947967,FALSE +"H1975","Input","KEGG_STEROID_BIOSYNTHESIS",-0.55301,-1.71,0.0458,8363,0.315,"SQLE, SOAT2, CYP27B1, DHCR24, MSMO1, FDFT1, HSD17B7, DHCR7, CYP51A1, TM7SF2",1.33913452199613,0.501689446210399,FALSE +"H1975","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.44592,-1.35,0.126,9071,0.426,"HSD17B7, AKR1D1, AKR1C3, AKR1C1, HSD11B2, HSD17B2",0.899629454882437,0.370590400897281,FALSE +"H1975","Input","KEGG_SULFUR_METABOLISM",-0.47961,-1.47,0.0816,9330,0.381,"SUOX, SULT1A1",1.08830984124614,0.419075024324381,FALSE +"H1975","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.4798,1.43,0.114,1782,0.704,"C4A, CD40, ACTN3, C3, ACTN1, C1R, TRIM21",0.943095148663527,0.152427340857888,FALSE +"H1975","Input","KEGG_TASTE_TRANSDUCTION",0.42289,1.3,0.154,209,0.63,"PRKACA, CACNA1A",0.812479279163537,0.200659450546418,FALSE +"H1975","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.54759,-1.68,0.0622,7326,0.283,"PDSS1, MVK, HMGCS1, ACAT2, IDI1, DHDDS, HMGCR",1.20620961530918,0.54821356447571,FALSE +"H1975","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.30038,0.903,0.552,2687,0.653,"THBS2, MYC, AMH, THBS1, SMURF1, RPS6KB2, RBL2, ZFYVE16, E2F4, MAPK1, PPP2CB, SMAD4, TGFBR1, ACVR1, E2F5, SMAD1, SMURF2, TGFB2",0.258060922270801,0.185086818724926,FALSE +"H1975","Input","KEGG_THYROID_CANCER",0.42462,1.27,0.177,3100,0.58,"TP53, MYC, PPARG, MAP2K2, NCOA4, MAPK1, TCF7L1, BRAF, RXRG, PAX8, TPM3, CCND1, CTNNB1, CDH1, TFG",0.752026733638193,0.236572006437063,FALSE +"H1975","Input","KEGG_TIGHT_JUNCTION",0.32384,0.979,0.446,1251,0.595,"MYH7, PRKCA, MYH11, MYL9, MYH9, PTEN, AKT1, PRKCH, LLGL1, CLDN4, ACTN3, RRAS2, MYL12A, MYH10, EPB41L2, PRKCB, GNAI2, CASK, PRKCD, CLDN16, CLDN6, EPB41L1, TJP2",0.350665141287858,0.22548303427145,FALSE +"H1975","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.3736,1.13,0.268,2278,0.601,"LY96, IRF5, CD40, AKT1, CASP8, MAP2K2, PIK3R2, IRAK4, TAB1, MAPK10, IRAK1, MYD88, MAPK8, IRF7, MAP2K4, CD14, PIK3CA, MAP3K7, IKBKG, TOLLIP, MAPK1, CHUK, IKBKB, TAB2, FADD, NFKB1, LBP",0.571865205971211,0.22112552799726,FALSE +"H1975","Input","KEGG_TRYPTOPHAN_METABOLISM",0.40515,1.21,0.217,1308,0.581,"MAOB, CYP1B1, KYNU, GCDH, EHHADH, MAOA",0.66354026615147,0.235823867609669,FALSE +"H1975","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.45913,1.38,0.112,2992,0.68,"CACNA1A, PIK3R2, MAPK10, PRKCD, MAPK8, PIK3CA, PKM, MAPK1, IRS1, IKBKB, HK2, IRS2, HK3, ABCC8, PKLR, MTOR, INSR, MAPK9",0.950781977329818,0.167491087293764,FALSE +"H1975","Input","KEGG_TYROSINE_METABOLISM",0.45094,1.35,0.135,1308,0.722,"ALDH3B1, MAOB, TAT, MIF, GSTZ1, TRMT11, MAOA",0.869666231504994,0.141462802430361,FALSE +"H1975","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.35193,1.05,0.359,3051,0.59,"PAK5, PAK6, CARD11, VAV2, VAV1, AKT1, MALT1, MAP2K2, RAF1, PIK3R2, PIK3CA, MAP3K7, IKBKG, PAK1, FYN, PPP3CA, MAPK1, CHUK, IKBKB, PPP3CB, CDK4, PDPK1, NFKB1, PAK3, NFATC3, CBL, SOS2, PAK2, MAPK14, BCL10, MAPK9, NFAT5",0.444905551421681,0.229147988357856,FALSE +"H1975","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.21391,0.648,0.891,1755,0.974,"UBA7, ITCH, UBE2O, CUL4B, UBE3C, HUWE1, UBA6, CUL7, KEAP1, MGRN1, SMURF1, FBXW11, HERC1, UBE2M, HERC4, WWP2, STUB1, UBA1, ERCC8, BIRC6, FBXW8, XIAP",0.0501222959631252,0.0114410431213845,FALSE +"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.25119,-0.756,0.752,8873,0.859,"BCAT1",0.123782159408358,0.0660068361687577,FALSE +"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.42544,-1.3,0.152,7467,0.433,"ACADM, ALDH6A1, ALDH7A1, HADH, HADHA, ACADS, OXCT1, ABAT, ALDH3A2, HMGCS1, ACAT2, HIBCH, BCAT1, ALDH2, DBT, AUH, MCEE",0.818156412055227,0.363512103646635,FALSE +"H1975","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.43447,1.28,0.168,1381,0.613,"CALD1, MYLK, PLA2G6, PRKACA, PRKCA, MYH11, MYL9, ITPR1, PRKCH, ARAF, ADCY7, GNA13, MYL6, PRKCB, MAP2K2, RAF1, GNA11, GNA12, PRKCD, MYL6B, CACNA1F",0.774690718274137,0.212539525481585,FALSE +"H1975","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.41656,1.27,0.167,2604,0.58,"PRKACA, DYNC1I2, DYNC1H1, DYNC1LI2, DCTN1, DYNC1LI1, DYNC2LI1, CREB5, DCTN2, RAB5B, DCTN4, DCTN5, DYNC2H1, PRKACB, GNAS, STX4, RAB5A",0.777283528852417,0.236572006437063,FALSE +"H1975","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.43332,1.33,0.156,1074,0.654,"NOS3, RAC2, PLA2G6, PRKCA, HSPB1, AKT1, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, MAPKAPK3",0.806875401645538,0.184422251675733,FALSE +"H1975","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.34744,1.06,0.358,2785,0.606,"PRKACA, PRKCA, KDELR1, PRKCB, PLCG2, TJP2, PRKACB, ATP6V1C1, ATP6V1G1, GNAS, ATP6V1D, ATP6V1E1, ATP6V1B2, TCIRG1",0.446116973356126,0.217527375833714,FALSE +"H1975","Input","KEGG_VIRAL_MYOCARDITIS",0.47521,1.45,0.0847,825,0.698,"MYH7, RAC2, CAV1, MYH11, MYH9, ICAM1, CD40, CASP8, MYH10",1.07211658966929,0.156144577376839,FALSE +"H1975","Input","KEGG_WNT_SIGNALING_PATHWAY",0.32988,1.02,0.395,2201,0.588,"RAC2, FZD2, TP53, PRKACA, PRKCA, PRICKLE1, MYC, WNT5B, DVL1, PRKCB, DVL2, FBXW11, MAPK10, PPP2R5E, MAPK8, DAAM1, MAP3K7, PPP2R5B, PPP3CA, PPP2CB, PPP3CB, APC, SMAD4, PRKACB, TCF7L1, PPP2R5C",0.40340290437354,0.230622673923862,FALSE +"H2009","Input","KEGG_ABC_TRANSPORTERS",0.32322,1.08,0.3,1760,0.502,"ABCG2, ABCD1, ABCC1, ABCA1, ABCC3",0.522878745280338,0.299296282854981,FALSE +"H2009","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.46475,-1.51,0.0702,7134,0.356,"RPS6KB1, MTOR, PIK3CB, MAP2K2, IKBKG, STAT5A, NFKB1, SOS1, RPS6KB2, PIK3R2, MAPK1, ARAF, RELA, AKT1, BRAF, MAPK3, PIK3CA, PIK3R1, AKT2, CEBPA, IKBKB, EIF4EBP1, RAF1, CCND1",1.15366288787019,0.448550002027125,FALSE +"H2009","Input","KEGG_ADHERENS_JUNCTION",0.26174,0.872,0.59,1714,0.673,"RAC2, CTNNB1, CDH1, CTNND1, CTNNA1, CTNNA2, LMO7, NECTIN4, TJP1, NECTIN1, ACTN4, BAIAP2, MET, AFDN, SSX2IP, ERBB2, IGF1R, SORBS1, PTPRJ, YES1, NECTIN2",0.229147988357856,0.171984935776023,FALSE +"H2009","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.49211,-1.55,0.0782,6982,0.355,"ACSL5, MAPK10, ACACB, MTOR, NFKBIB, IKBKG, PRKCQ, NFKB1, STK11, PRKAG2, TRAF2, PRKAB2, CPT1A, PCK2, MAPK8, PRKAB1, NFKBIE, RELA, AKT1, CAMKK2, PTPN11, PRKAA1, AKT2, PRKAG1, IKBKB",1.10679324694015,0.449771646944906,FALSE +"H2009","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.41557,-1.33,0.132,8405,0.351,"CAD, ADSL, ASL, NIT2, ASNS, CPS1, ASS1",0.87942606879415,0.454692883534176,FALSE +"H2009","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.24436,-0.792,0.713,6160,0.808,"IRS2, INSR, PRKCA, HSD11B2, PRKCB, PIK3CB, PIK3R2, MAPK1, NEDD4L, MAPK3, PIK3CA, PIK3R1",0.146910470148134,0.0925886392254138,FALSE +"H2009","Input","KEGG_ALZHEIMERS_DISEASE",-0.1856,-0.595,0.958,6977,0.975,"CDK5, ATP5PB, CAPN2, NDUFAB1, CASP9, COX6C, CASP8, CASP3, MAPK1, BACE2, ATP2A3, APAF1, IDE, FADD, GAPDH, APBB1, MAPK3, MME, CAPN1, GSK3B, PLCB4, CASP7, PLCB2",0.0186344909214556,0.0109953843014632,FALSE +"H2009","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.23689,-0.777,0.722,5956,0.827,"NARS2, FARS2, SARS2, EARS2, WARS2, MTFMT, FARSB, VARS2, FARSA, SEPSECS",0.141462802430361,0.0824944904474534,FALSE +"H2009","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.6384,-2.06,0.0102,6681,0.349,"NANS, GFPT2, GMPPA, UGP2, GCK, CYB5R1, GNE, HK3, NAGK, GALE, PGM2, GALK1, PGM1, GFPT1, GALK2, PMM2, GMDS, MPI, PGM3, PMM1, GNPDA2, GMPPB, GALT, UAP1, FPGT, GNPNAT1, GNPDA1, GPI, AMDHD2",1.99139982823808,0.45717457304082,FALSE +"H2009","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.25587,-0.838,0.603,7014,0.766,"CCS, CASP9, MAPK14, MAPK12, CASP1, CASP3, NEFM, PRPH, PRPH2, APAF1, BAX, SOD1, MAP2K3",0.219682687859849,0.115771230367396,FALSE +"H2009","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.2992,0.967,0.473,2758,0.554,"CTSS, CTSL, CD74, RFXAP, RFXANK, CTSB, CALR, HSPA5, CREB1, RFX5, TAPBP, PSME3, NFYB, HSPA1L, IFI30, PDIA3",0.325138859262188,0.25649023527157,FALSE +"H2009","Input","KEGG_APOPTOSIS",-0.33497,-1.08,0.331,7026,0.471,"CAPN2, IRAK4, PIK3CB, CASP9, CASP6, IKBKG, NFKB1, BIRC2, CASP8, CASP3, TRAF2, PIK3R2, APAF1, IL1A, MYD88, RIPK1, BAX, RELA, AKT1, FADD, DFFB, PIK3CA, CAPN1, PIK3R1, AKT2, CASP7, IKBKB",0.480172006224281,0.326979092871104,FALSE +"H2009","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.31385,1.03,0.365,356,0.526,"GPX1, PLA2G12A, GGT5",0.437707135543525,0.279014255846261,FALSE +"H2009","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.25409,0.852,0.626,575,0.698,"GLUD2, GATM, ARG1, ALDH1B1, OAT, MAOA, PYCR1",0.20342566678957,0.156144577376839,FALSE +"H2009","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.7275,2.42,0,765,0.14,"ITGB6, ITGB4, ITGA2B, DSC2, GJA1, ITGA6, DSG2, PKP2, ITGA3, CTNNB1, LMNA, ITGA4, ITGB8, CTNNA1, CTNNA2, ITGA5, ITGA2, ITGAV, ACTN4",Inf,0.853871964321762,TRUE +"H2009","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.56676,1.79,0.0212,2597,0.19,"ALDH1B1, ALDH2, UGDH, ALDH7A1, ALDH3A2",1.67366413907125,0.721246399047171,TRUE +"H2009","Input","KEGG_AXON_GUIDANCE",0.23453,0.778,0.732,1058,0.77,"RAC2, SEMA4B, EFNB2, EPHA1, SEMA4D, EPHA2, HRAS, ROBO1, EPHB2, KRAS, NRAS, MET, PLXNB2, SEMA7A",0.135488918941608,0.113509274827518,FALSE +"H2009","Input","KEGG_BASAL_CELL_CARCINOMA",0.32696,1.05,0.354,2067,0.527,"TP53, CTNNB1, FZD6, DVL1, WNT5B, FZD7, APC",0.450996737974212,0.278189384787453,FALSE +"H2009","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.15908,0.518,0.99,6214,1,"TAF12, GTF2H1, TAF4, TAF11, TAF5, GTF2I, GTF2B, GTF2H2, TAF5L, TAF6, TAF9, TAF10, GTF2F2, TAF1, GTF2H3, TAF2, GTF2E2, GTF2H4, GTF2F1, TAF7, TAF6L, GTF2E1, GTF2A2, TAF9B, TBP, GTF2A1",0.00436480540245009,0,FALSE +"H2009","Input","KEGG_BASE_EXCISION_REPAIR",-0.25731,-0.836,0.637,5421,0.761,"POLE4, UNG, PARP1, POLE2, POLL, MUTYH, POLE, FEN1, PARP4, MPG, NTHL1, NEIL2, SMUG1, HMGB1, APEX1",0.19586056766465,0.118615343229427,FALSE +"H2009","Input","KEGG_BETA_ALANINE_METABOLISM",0.40571,1.33,0.145,2236,0.341,"ACADM, ALDH1B1, ECHS1, HADHA, ALDH2, SMS, ALDH7A1",0.838631997765025,0.467245621007502,FALSE +"H2009","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.46174,1.5,0.0995,1789,0.246,"FADS2, ACAA1, ACOX1, PECR, HADHA, ELOVL6, ELOVL5, FADS1",1.00217691925427,0.609064892896621,FALSE +"H2009","Input","KEGG_BLADDER_CANCER",0.33547,1.1,0.31,1410,0.495,"TP53, MMP1, CDH1, VEGFA, CDKN2A, HRAS, KRAS, NRAS, CXCL8, ERBB2, VEGFC, MYC",0.508638306165727,0.305394801066431,FALSE +"H2009","Input","KEGG_BUTANOATE_METABOLISM",0.44758,1.46,0.0853,2315,0.267,"ALDH1B1, OXCT1, ACAT1, ECHS1, HADH, HADHA, PDHA1, PDHB, ALDH2, ALDH7A1, HMGCL",1.06905096883248,0.573488738635425,FALSE +"H2009","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.34974,-1.11,0.314,6569,0.468,"BTK, BCL10, VAV3, PPP3CC, PTPN6, PIK3AP1, MAP2K1, PRKCB, PIK3CB, NFKBIB, PLCG2, MAP2K2, IKBKG, NFKB1, SOS1, NFATC2, PIK3R2, MAPK1, VAV2, NFKBIE, RELA, AKT1, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, MALT1, IKBKB, RAF1",0.503070351926785,0.329754146925876,FALSE +"H2009","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.19421,-0.628,0.934,7972,0.964,"PHKG2, ATP2A3, PHKB, SLC8A1, PDGFRA, PDGFRB, PPID, P2RX4, PLCG1, PLCB4, PLCB2",0.0296531237699066,0.0159229660971692,FALSE +"H2009","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.34627,1.16,0.241,1871,0.443,"TNNC1, ATP1A2, SLC9A6, ATP1B1, SLC9A1, UQCRH, CACNA2D1, UQCRB, UQCRFS1",0.617982957425132,0.35359627377693,FALSE +"H2009","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.57772,1.89,0.022,843,0.197,"CDH15, CDH3, CNTN1, ITGB2, CD274, CLDN7, ITGA6, F11R, SDC4, ALCAM, CDH1, ITGA4, ITGB8, NLGN2, CD276, ITGAV, CD58, CD99, NECTIN1, ICAM2, PVR, ICAM1",1.65757731917779,0.705533773838407,TRUE +"H2009","Input","KEGG_CELL_CYCLE",-0.22933,-0.736,0.786,7610,0.853,"CCND3, TFDP2, CDK1, ABL1, YWHAQ, YWHAG, BUB1B, CDKN1A, SMAD2, TGFB3, ORC6, CDK6, GSK3B, PTTG1, CDKN1B, CDKN2C, CCND1, RB1",0.104577453960592,0.069050968832477,FALSE +"H2009","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.4488,-1.41,0.121,7050,0.359,"PRKCB, ROCK1, PXN, PIK3CB, NFKBIB, PTK2B, IKBKG, CRKL, NFKB1, SOS1, GNAI1, PTK2, PIK3R2, MAPK1, VAV2, GSK3A, CRK, ROCK2, FOXO3, PRKCZ, ADCY5, RELA, PREX1, AKT1, BRAF, GRK2, MAPK3, ADCY6, PIK3CA, CCL13, CCL20, GSK3B, PIK3R1, AKT2, PLCB4, STAT2, IKBKB, ELMO1, CSK, PLCB2, RAF1, CXCR4, WAS",0.91721462968355,0.444905551421681,FALSE +"H2009","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.44086,-1.4,0.116,7329,0.362,"MAP2K2, IKBKG, CRKL, STAT5A, NFKB1, SOS1, ABL1, PIK3R2, MAPK1, CRK, ARAF, CDKN1A, RELA, CBL, AKT1, BRAF, TGFB3, MAPK3, PTPN11, PIK3CA, CDK6, PIK3R1, AKT2, CBLB, IKBKB, CDKN1B, GAB2, RAF1, CCND1, RB1",0.935542010773082,0.441291429466834,FALSE +"H2009","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.65024,2.16,0.00714,1274,0.173,"BHLHE41, BHLHE40, CLOCK",2.14630178822383,0.761953896871205,TRUE +"H2009","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.30027,0.987,0.407,3184,0.532,"SDHA, SDHB, IDH3A, PDHA1, PDHB, SUCLG2, SUCLG1, DLST, MDH2, ACO2, IDH3G, FH, PC, DLD, IDH3B, SDHD",0.39040559077478,0.274088367704952,FALSE +"H2009","Input","KEGG_COLORECTAL_CANCER",-0.29448,-0.948,0.471,6980,0.615,"MAP2K1, APPL1, MAPK10, PIK3CB, CASP9, CASP3, PIK3R2, MAPK1, MAPK8, ARAF, SMAD2, BAX, AKT1, BRAF, TGFB3, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, RAF1, CCND1",0.326979092871104,0.211124884224583,FALSE +"H2009","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.56122,1.83,0.0287,587,0.18,"PLAT, F3, SERPINA1, PLAU, THBD, MBL2, CFI, PLAUR, TFPI, CD55, PROS1",1.54211810326601,0.744727494896694,TRUE +"H2009","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.42514,-1.35,0.14,6006,0.353,"AHCYL1, AHCYL2, LDHB, TAT, MPST, MAT2A, CTH, ADI1, MTR, MAT1A, ENOPH1, SDS, LDHA, AHCY, CDO1, CBS, SRM",0.853871964321762,0.452225294612177,FALSE +"H2009","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.28406,0.91,0.564,2322,0.619,"LIFR, OSMR, TNFRSF1A, VEGFA, TNFSF9, IL13RA1, EPO, IL1R1, LTBR, MET, IL1RAP, TGFB2, CXCL8, VEGFC, TNFRSF10B, PDGFC, TNFRSF12A, TNFRSF10A, ACVR1, TNFSF13B, IL10RB, IL25, CD40",0.248720896016658,0.208309350979882,FALSE +"H2009","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.38272,-1.22,0.222,7218,0.41,"NFKBIB, IKBKG, NFKB1, CASP1, IRF3, IL18, DDX58, RIPK1, TBK1, RELA, PYCARD, IKBKB",0.653647025549361,0.387216143280265,FALSE +"H2009","Input","KEGG_DILATED_CARDIOMYOPATHY",0.53846,1.76,0.0502,1330,0.196,"ITGB6, TNNC1, ITGB4, ITGA2B, ITGA6, ITGA3, LMNA, ITGA4, ITGB8, ITGA5, ITGA2, ITGAV, TTN, SGCB, TGFB2, CACNA2D1, DAG1",1.29929628285498,0.707743928643524,FALSE +"H2009","Input","KEGG_DNA_REPLICATION",0.30351,1,0.389,3899,0.541,"POLA2, MCM3, POLD4, RFC4, SSBP1, RFC1, RFC2, RNASEH2A, RPA3, MCM4, RFC3, RFC5, MCM7, POLD3, MCM2, POLE3, POLA1, PRIM2, RPA2, PCNA, MCM6, POLD2, MCM5, RPA1, LIG1",0.410050398674292,0.266802734893431,FALSE +"H2009","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.3217,1.06,0.346,866,0.522,"NOTCH3, ETV6, KRAS",0.460923901207223,0.282329496997738,FALSE +"H2009","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.43435,-1.41,0.107,8535,0.359,"ALDH3A1, GSTZ1, GSTO1, GSTP1, GSTM3, ADH5",0.97061622231479,0.444905551421681,FALSE +"H2009","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.42153,-1.33,0.14,6255,0.351,"GUSB, UCK2, UCK1, TK1, TK2, IMPDH1, GMPS, UPP1, NAT1, DPYD, XDH, HPRT1, IMPDH2, UMPS, TPMT, ITPA",0.853871964321762,0.454692883534176,FALSE +"H2009","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.64879,2.14,0.00481,772,0.142,"ITGB6, LAMC2, COL6A1, TNC, ITGB4, ITGA2B, LAMB3, ITGA6, ITGA3, SDC4, ITGA4, ITGB8, LAMA3, LAMA4, ITGA5, ITGA2, LAMB1, ITGAV, COL6A6, CD47",2.31785492362617,0.847711655616944,TRUE +"H2009","Input","KEGG_ENDOCYTOSIS",-0.37891,-1.21,0.236,6772,0.415,"EHD4, SMAP2, VPS37C, SH3GLB2, PARD6G, CLTC, SH3GLB1, PARD6B, CHMP6, F2R, VPS36, RABEP1, ASAP1, DNM3, VPS4A, EHD2, MVB12A, PDCD6IP, ASAP2, VTA1, DNM2, SH3GL1, USP8, CHMP4A, CHMP4B, VPS28, LDLRAP1, PRKCZ, NEDD4L, VPS37A, VPS4B, ACAP2, PDGFRA, TSG101, NEDD4, CBL, SNF8, PRKCI, ARFGAP2, EHD1, SMAP1, GRK2, FGFR2, CHMP5, IQSEC1, EHD3, TRAF6, CHMP2A, VPS25, ARAP2, CBLB, ARAP1, ACAP3, CXCR4, ARFGAP1, ARFGAP3",0.627087997029893,0.381951903287907,FALSE +"H2009","Input","KEGG_ENDOMETRIAL_CANCER",-0.30712,-1,0.399,7206,0.573,"PIK3CB, CASP9, MAP2K2, SOS1, PTEN, PIK3R2, MAPK1, FOXO3, ARAF, AKT1, BRAF, ILK, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, RAF1, CCND1",0.399027104313252,0.24184537803261,FALSE +"H2009","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.35331,-1.12,0.293,7031,0.467,"MAPK10, ATP6V1E1, ATP6V1G1, PLCG2, IKBKG, NFKB1, MAPK14, MAPK12, CASP3, ATP6V1H, MAPK8, MAP2K4, ATP6V1B2, ATP6V1B1, ATP6V1A, ATP6V1C1, RELA, PTPN11, JAM3, PLCG1, IKBKB, CSK",0.533132379645891,0.330683119433888,FALSE +"H2009","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.41731,-1.33,0.129,6980,0.351,"MAP2K1, PAK3, MAPK10, PRKCB, RPS6KB1, MTOR, CAMK2B, PIK3CB, PAK2, PLCG2, MAP2K2, NCK1, CRKL, STAT5A, SOS1, RPS6KB2, MAP2K7, PTK2, ABL1, PIK3R2, MAPK1, MAPK8, MAP2K4, CRK, ARAF, CDKN1A, CBL, AKT1, BRAF, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, PLCG1, CBLB, CDKN1B, EIF4EBP1, RAF1",0.889410289700751,0.454692883534176,FALSE +"H2009","Input","KEGG_ETHER_LIPID_METABOLISM",0.58448,1.94,0.0169,795,0.219,"LPCAT1, PLPP2, PLA2G12A, CHPT1, PLPP3, LPCAT2, AGPS",1.77211329538633,0.659555885159882,TRUE +"H2009","Input","KEGG_FATTY_ACID_METABOLISM",0.49933,1.66,0.0542,1776,0.207,"ACADM, ALDH1B1, ACAA1, ACOX1, ACADVL, CPT2, ACAT1, ECHS1, HADHB, HADH, HADHA, ACSL4, ACADSB, ECI2, ACSL3, ALDH2",1.26600071346161,0.684029654543082,FALSE +"H2009","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.34406,-1.1,0.318,6980,0.449,"MAP2K1, MAPK10, PRKCB, PIK3CB, PLCG2, MAP2K2, MAPK14, MAPK12, SOS1, MAP2K7, PIK3R2, MAPK1, VAV2, MAPK8, MAP2K4, AKT1, MAPK3, PIK3CA, PIK3R1, AKT2, PLCG1, MAP2K3, GAB2, RAF1",0.497572880015567,0.347753658996677,FALSE +"H2009","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.33471,-1.1,0.301,6267,0.449,"ARPC2, PRKCA, PAK1, ARPC4, DNM1L, PIP4K2B, ARPC1A, VAV3, CFL1, WASL, MAP2K1, PRKCB, RPS6KB1, PIK3CB, PLCG2, AMPH, CRKL, ASAP1, LIMK2, DNM3, RPS6KB2, ASAP2, DNM2, PIK3R2, MAPK1, VAV2, CRK, AKT1, MAPK3, PIK3CA, PIK3R1, AKT2, PLCG1, GAB2, RAF1, WAS",0.521433504406157,0.347753658996677,FALSE +"H2009","Input","KEGG_FOCAL_ADHESION",0.33848,1.13,0.265,765,0.474,"ITGB6, LAMC2, RAC2, COL6A1, TNC, ITGB4, ITGA2B, LAMB3, ITGA6, ITGA3, CAV2, CTNNB1, VEGFA, ITGA4, ITGB8, LAMA3, LAMA4, PIK3R3, ITGA5, FLNB, ITGA2, HRAS, LAMB1, ITGAV, COL6A6, JUN, ACTN4",0.576754126063192,0.324221658325915,FALSE +"H2009","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.54975,-1.79,0.0322,5955,0.414,"QDPR, PTS, SPR, DHFR",1.49214412830417,0.382999658879101,FALSE +"H2009","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.52604,-1.71,0.0414,7189,0.372,"HK3, TPI1, ALDOA, SORD, KHK, PMM2, GMDS, MPI, PMM1, PHPT1, PFKFB3, GMPPB, PFKP, MTMR2, MTMR6, FPGT, PFKM, PFKL",1.3829996588791,0.429457060118102,FALSE +"H2009","Input","KEGG_GALACTOSE_METABOLISM",-0.48625,-1.53,0.0747,6911,0.348,"UGP2, GCK, HK3, GALE, PGM2, GALK1, PGM1, GALK2, PFKP, GALT, PFKM, PFKL",1.1266793981846,0.458420756053419,FALSE +"H2009","Input","KEGG_GAP_JUNCTION",-0.45665,-1.49,0.0799,7537,0.366,"SOS1, GNAI1, CDK1, TUBB4B, MAPK1, MAPK7, ADCY5, PDGFRA, PDGFRB, TUBA1C, TUBB1, TUBB3, MAP2K5, MAPK3, TUBB, TUBB6, ADCY6, TUBA3C, TUBA1B, TUBB2A, TUBAL3, PLCB4, PLCB2, RAF1, TUBB2B",1.09745322068601,0.436518914605589,FALSE +"H2009","Input","KEGG_GLIOMA",-0.39128,-1.25,0.205,6980,0.409,"MAP2K1, PRKCB, MTOR, CAMK2B, PIK3CB, PLCG2, MAP2K2, SOS1, PTEN, PIK3R2, MAPK1, ARAF, CDKN1A, PDGFRA, PDGFRB, AKT1, BRAF, MAPK3, PIK3CA, CDK6, PIK3R1, AKT2, PLCG1, RAF1, CCND1, RB1",0.688246138944246,0.388276691992658,FALSE +"H2009","Input","KEGG_GLUTATHIONE_METABOLISM",-0.44793,-1.45,0.0938,8007,0.373,"RRM2B, GCLC, OPLAH, PGD, GGCT, GSTZ1, GSTO1, GSTP1, RRM2, GSTM3, SRM, LAP3, RRM1",1.02779716162094,0.428291168191312,FALSE +"H2009","Input","KEGG_GLYCEROLIPID_METABOLISM",0.30294,0.961,0.457,483,0.553,"ALDH1B1, PLPP2, DGKE, PLPP3, GPAT3, GLA",0.34008379993015,0.257274868695302,FALSE +"H2009","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.32367,1.1,0.275,380,0.495,"PEMT, LPCAT1, PLPP2, DGKE, PLA2G12A, CHPT1, PLPP3, GPAT3",0.560667306169737,0.305394801066431,FALSE +"H2009","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.36317,1.2,0.215,713,0.423,"PIPOX, GATM, MAOA, BHMT",0.667561540084395,0.373659632624958,FALSE +"H2009","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.44311,-1.39,0.12,6930,0.344,"GCK, BPGM, PKM, HK3, TPI1, PGM2, ALDOA, PGM1, ENO1, LDHA, PCK2, PGAM1, PGAM4, ENO3, PKLR, ACSS2, PGK1, GAPDH, ALDH3A1, PFKP, GPI, PFKM, AKR1A1, ADH5, PFKL",0.920818753952375,0.46344155742847,FALSE +"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.3152,1.04,0.309,2826,0.532,"CHST11, CHST3, CHST12, XYLT2, DSE, CHST7",0.510041520575165,0.274088367704952,FALSE +"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.4217,1.4,0.116,2292,0.3,"HS6ST1, EXTL2, HS6ST2, XYLT2",0.935542010773082,0.522878745280338,FALSE +"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.40924,1.36,0.13,455,0.319,"B4GALT3, B4GALT1",0.886056647693163,0.496209316942819,FALSE +"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.25099,-0.799,0.681,8293,0.804,"HGSNAT, HYAL1",0.166852888087215,0.0947439512515487,FALSE +"H2009","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.77325,-2.51,0,8777,0.0853,"ST3GAL2, B4GALNT1",Inf,1.06905096883248,TRUE +"H2009","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.5863,1.94,0.0185,483,0.219,"B3GALNT1, GLA",1.73282827159699,0.659555885159882,TRUE +"H2009","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.67762,2.27,0.00455,944,0.154,"B3GNT3, B4GALT3, B4GALT1, ST3GAL4",2.34198860334289,0.812479279163537,TRUE +"H2009","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.51447,-1.66,0.0385,5557,0.334,"PIGT, PIGK, GPAA1, PIGO, PIGH, PIGM, PIGQ, PIGU",1.4145392704915,0.476253533188435,FALSE +"H2009","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.36586,-1.18,0.229,6932,0.434,"PGP, GRHPR, MDH1, HYI, ACO1, MTHFD1",0.640164517660112,0.362510270487489,FALSE +"H2009","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.37235,-1.18,0.227,5995,0.434,"ITPR2, CDC42, PRKCD, GNAS, PRKACA, PRKCA, MAP3K3, MAPK9, MAP3K2, ATF4, PLCB3, MAP2K1, MAPK10, PRKCB, CAMK2B, PTK2B, MAP2K2, MAPK14, MAPK12, SOS1, MAP2K7, MAPK1, MAPK8, MAP2K4, MAPK7, MAP3K4, ADCY5, MAPK3, ADCY6, PLCB4, MAP2K3, PLCB2, RAF1",0.643974142806877,0.362510270487489,FALSE +"H2009","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.4298,-1.36,0.144,8848,0.351,"GSK3B, GLI3",0.84163750790475,0.454692883534176,FALSE +"H2009","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.56575,1.86,0.0248,819,0.197,"ITGA2B, ITGA6, ITGA3, ITGA4, CD55, ITGA5, ITGA2, EPO, IL1R1",1.60554831917378,0.705533773838407,TRUE +"H2009","Input","KEGG_HISTIDINE_METABOLISM",0.24155,0.797,0.683,473,0.749,"ALDH1B1, HNMT, MAOA",0.165579296318467,0.125518182300534,FALSE +"H2009","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.35613,1.18,0.244,3718,0.427,"EME1, RAD51, POLD4, SSBP1, MUS81, RPA3, TOP3A, NBN, POLD3, BRCA2, RAD54L, RPA2, TOP3B, POLD2",0.612610173661271,0.369572124974976,FALSE +"H2009","Input","KEGG_HUNTINGTONS_DISEASE",0.16114,0.537,0.991,2692,1,"TP53, GPX1, SDHA, RCOR1, POLR2D, NDUFA8, POLR2L, UQCRH, SDHB, POLR2I, SIN3A, POLR2K, CREB5, NDUFS6, POLR2G, UQCRB, CREB1, POLR2J, CLTA, UQCRFS1, NDUFA7, POLR2C, NDUFB1, NDUFA2, NDUFV2, POLR2F, TAF4, UQCRC1, DLG4, VDAC1, POLR2E, NDUFS8, IFT57, NDUFS4, NDUFS5, EP300, HIP1, CLTB, NDUFV3, NDUFB10, NDUFB8, VDAC2, GNAQ, AP2A1",0.00392634551472468,0,FALSE +"H2009","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.48698,1.6,0.0656,1330,0.225,"ITGB6, TNNC1, ITGB4, ITGA2B, ITGA6, ITGA3, LMNA, ITGA4, ITGB8, ITGA5, ITGA2, ITGAV, TTN, SGCB, TGFB2, CACNA2D1, DAG1",1.18309616062434,0.647817481888638,FALSE +"H2009","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.51927,-1.65,0.0543,6581,0.326,"PIP4K2B, PI4KB, CDIPT, INPP4A, PLCB3, IMPA2, PIK3CB, MINPP1, TPI1, PLCG2, INPP5B, PTEN, SYNJ1, PIK3C2B, OCRL, PIK3CA, IMPA1, ITPK1, ISYNA1, INPPL1, PIK3C3, PLCG1, PLCB4, INPP1, PLCB2",1.26520017041115,0.486782399932061,FALSE +"H2009","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.42533,-1.36,0.128,6930,0.351,"GCK, MAP2K1, MAPK10, PHKA1, TSC1, ACACB, RPS6KB1, RPS6, MTOR, HK3, RAPGEF1, PIK3CB, MAP2K2, CRKL, MKNK2, SOS1, RPS6KB2, PRKAG2, PRKAB2, PIK3R2, MAPK1, PCK2, MAPK8, CRK, PHKG2, PRKAB1, ARAF, PRKCZ, PHKB, MKNK1, GYS1, PKLR, CBL, AKT1, BRAF, PRKCI, MAPK3, PPP1R3D, PRKAA1, PIK3CA, TSC2, GSK3B, PIK3R1, AKT2, PRKAG1, SOCS2, CBLB, IKBKB, FOXO1, EIF4EBP1, RAF1",0.892790030352132,0.454692883534176,FALSE +"H2009","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.38142,-1.25,0.183,8592,0.409,"ICOSLG, CXCR4",0.737548910269571,0.388276691992658,FALSE +"H2009","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.34591,-1.11,0.282,8325,0.468,"CBL, AKT1, PTPN11, PIK3CA, PIK3R1, STAT6, AKT2, SOCS2, CBLB, STAT2, PIAS4, CCND1, SPRY4",0.549750891680639,0.329754146925876,FALSE +"H2009","Input","KEGG_LEISHMANIA_INFECTION",-0.30183,-0.978,0.445,6703,0.587,"STAT1, PTPN6, MAP3K7, PRKCB, IRAK4, C3, NFKBIB, NFKB1, MAPK14, MAPK12, MAPK1, IL1A, MYD88, RELA, TGFB3, MAPK3, TAB2, TRAF6",0.351639989019068,0.231361898752386,FALSE +"H2009","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.29643,0.995,0.369,958,0.529,"ITGB2, RAC2, CLDN7, F11R, CTNNB1, SIPA1, CTNND1, ITGA4, CTNNA1, CTNNA2, PIK3R3, CD99, ACTN4, ICAM1, PIK3CD",0.43297363384094,0.276544327964814,FALSE +"H2009","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.37952,1.26,0.18,2597,0.374,"ALDH1B1, ECHS1, HADHA, ALDH2, ALDH7A1, ALDH3A2",0.744727494896694,0.42712839779952,FALSE +"H2009","Input","KEGG_LONG_TERM_DEPRESSION",-0.27573,-0.881,0.577,6833,0.704,"PLCB3, PPP2CA, MAP2K1, PRKCB, GUCY1A1, MAP2K2, GNAI1, PPP2R1B, MAPK1, GNA12, ARAF, BRAF, MAPK3, PPP2CB, PLCB4, GNA13, PLCB2, RAF1",0.238824186844269,0.152427340857888,FALSE +"H2009","Input","KEGG_LONG_TERM_POTENTIATION",-0.29808,-0.951,0.467,6292,0.617,"PRKACA, PRKCA, ATF4, PPP3CC, PLCB3, MAP2K1, PRKCB, CAMK2B, MAP2K2, MAPK1, ARAF, BRAF, MAPK3, PLCB4, PLCB2, RAF1",0.330683119433888,0.209714835966758,FALSE +"H2009","Input","KEGG_LYSINE_DEGRADATION",0.4429,1.45,0.0945,2236,0.265,"PIPOX, ALDH1B1, NSD2, ACAT1, ECHS1, DOT1L, PLOD2, EHMT1, HADH, HADHA, ASH1L, ALDH2, SETD2, AASS, DLST, SUV39H1, ALDH7A1",1.02456819149074,0.576754126063192,FALSE +"H2009","Input","KEGG_LYSOSOME",-0.20063,-0.631,0.933,7680,0.971,"SMPD1, ATP6V1H, AP3M2, CLN3, MANBA, GALC, AP3B1, AP1M1, HGSNAT, HYAL1, AP3M1, AP3S2, AP4E1, AP4M1, AP3S1, AP3D1, CTSG, CLN5",0.0301183562535,0.0127807700919951,FALSE +"H2009","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.3404,-1.1,0.302,7329,0.449,"MAP2K2, IKBKG, CRKL, NFKB1, HSPB1, MAPK14, MAPK12, MKNK2, SOS1, MAP2K7, CASP3, MAP4K2, TRAF2, RAPGEF2, NFATC2, MAP3K20, MAPK1, MAPK8, GNA12, MAP2K4, CRK, MAPK7, MAP3K4, IL1A, MKNK1, PDGFRA, MAPKAPK2, RELA, PDGFRB, RASA2, AKT1, BRAF, TGFB3, MAP2K5, MAPK3, FGFR2, PPM1A, DUSP3, MEF2C, NLK, NFKB2, TAB2, STK4, TRAF6, AKT2, STMN1, IKBKB, PPP5C, MAP2K3, FGFR1, RAF1",0.519993057042849,0.347753658996677,FALSE +"H2009","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.44743,-1.44,0.101,6930,0.371,"GCK, IAPP, PKLR, MNX1",0.995678626217357,0.430626090384954,FALSE +"H2009","Input","KEGG_MELANOGENESIS",-0.25611,-0.816,0.657,6744,0.78,"MITF, PLCB3, MAP2K1, PRKCB, CAMK2B, DCT, MAP2K2, DVL3, GNAI1, MAPK1, ADCY5, MAPK3, ADCY6, GSK3B, PLCB4, PLCB2, RAF1",0.182434630440219,0.10790539730952,FALSE +"H2009","Input","KEGG_MELANOMA",-0.3888,-1.23,0.207,7715,0.404,"PTEN, PIK3R2, MAPK1, ARAF, CDKN1A, PDGFRA, PDGFRB, AKT1, BRAF, MAPK3, PIK3CA, CDK6, PIK3R1, AKT2, FGFR1, RAF1, CCND1, RB1",0.684029654543082,0.393618634889395,FALSE +"H2009","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.52225,-1.69,0.0436,7659,0.37,"AKR1C1, AKR1C3, GSTT2, ALDH3A1, GSTZ1, GSTO1, GSTP1, GSTM3, ADH5",1.36051351073141,0.431798275933005,FALSE +"H2009","Input","KEGG_MISMATCH_REPAIR",0.55276,1.84,0.0209,3899,0.191,"POLD4, RFC4, SSBP1, RFC1, RFC2, MSH6, RPA3, MSH2, RFC3, MLH1, RFC5, PMS2, POLD3, RPA2, PCNA, POLD2, RPA1, LIG1",1.67985371388895,0.718966632752272,TRUE +"H2009","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.53238,-1.73,0.0325,7054,0.379,"TSC1, RPS6KB1, RPS6, MTOR, PIK3CB, RPS6KB2, STK11, PIK3R2, MAPK1, EIF4B, AKT1, BRAF, MAPK3, PRKAA1, PIK3CA, CAB39L, TSC2, STRADA, PIK3R1, AKT2, EIF4EBP1",1.48811663902113,0.421360790031928,FALSE +"H2009","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.35859,1.18,0.231,958,0.427,"ITGB2, RAC2, RAET1L, ULBP2, ULBP3, MICA, MICB, PIK3R3, HRAS, ICAM2, ICAM1, KRAS, NRAS, PIK3CD",0.636388020107856,0.369572124974976,FALSE +"H2009","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.41258,-1.32,0.152,5764,0.348,"HTR2B, NR3C1, F2, PLG, TACR1, CHRNE, PRSS1, F2R, HCRTR1, TSPO, P2RX4, CTSG",0.818156412055227,0.458420756053419,FALSE +"H2009","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.4355,-1.39,0.138,6980,0.344,"MAP2K1, YWHAE, MAPK10, IRAK4, CAMK2B, RAPGEF1, PIK3CB, NFKBIB, PLCG2, MAP2K2, CRKL, NFKB1, YWHAB, MAPK14, MAPK12, SOS1, MAP2K7, RIPK2, ABL1, PIK3R2, MAPK1, YWHAQ, MAPK8, YWHAG, ARHGDIA, CRK, MAPK7, FOXO3, NFKBIE, MAPKAPK2, BAX, RELA, AKT1, BRAF, NGFR, MAP2K5, MAPK3, PTPN11, PIK3CA, TRAF6, GSK3B, PIK3R1, AKT2, PLCG1, IKBKB, CSK, RAF1",0.860120913598763,0.46344155742847,FALSE +"H2009","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.34527,-1.1,0.315,6958,0.449,"NT5C3A, NT5C2, NADSYN1, NT5C, PNP, NAMPT, NNMT, NMRK1",0.501689446210399,0.347753658996677,FALSE +"H2009","Input","KEGG_NITROGEN_METABOLISM",-0.45186,-1.42,0.102,8377,0.371,"CA1, CA12, CA9, ASNS, CPS1, CA8",0.991399828238082,0.430626090384954,FALSE +"H2009","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.56179,-1.78,0.0241,6749,0.381,"MAP3K7, SUGT1, MAPK10, NFKBIB, IKBKG, TRIP6, NFKB1, MAPK14, BIRC2, MAPK12, CASP8, CASP1, RIPK2, MAPK1, MAPK8, HSP90AB1, CARD6, IL18, HSP90AA1, RELA, PYCARD, MAPK3, CCL13, TAB2, TRAF6, IKBKB",1.61798295742513,0.419075024324381,FALSE +"H2009","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.257,-0.831,0.64,8909,0.762,"NHEJ1",0.193820026016113,0.1180450286604,FALSE +"H2009","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.34885,-1.12,0.265,6980,0.467,"MAP2K1, PRKCB, PIK3CB, CASP9, PLCG2, MAP2K2, SOS1, PIK3R2, MAPK1, FOXO3, ARAF, AKT1, BRAF, MAPK3, PIK3CA, CDK6, STK4, PIK3R1, AKT2, PLCG1, RAF1, CCND1, RB1",0.576754126063192,0.330683119433888,FALSE +"H2009","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.38446,1.26,0.183,2904,0.374,"NOTCH3, DTX2, HES1, CTBP1, JAG1, DVL1, CTBP2, RBPJ, DTX3L, NUMB, EP300, NCOR2, SNW1, CREBBP",0.737548910269571,0.42712839779952,FALSE +"H2009","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.26599,0.849,0.637,3545,0.693,"ERCC5, ERCC8, GTF2H5, MNAT1, POLD4, RFC4, GTF2H1, RFC1, RFC2, RPA3, RFC3, RFC5, RBX1, RAD23B, POLD3, POLE3, CUL4A, GTF2H2, RPA2, PCNA",0.19586056766465,0.159266765388193,FALSE +"H2009","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.24801,0.814,0.66,2528,0.732,"B4GALT3, B4GALT1, TUSC3, ALG2, ALG10, ALG10B, MAN2A1, FUT8, MGAT2, MAN1A1, MOGS, MAN2A2",0.180456064458131,0.135488918941608,FALSE +"H2009","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.42598,-1.37,0.13,6177,0.358,"PRKG1, PRKACA, ARRB2, CAMK2B, CLCA2",0.886056647693163,0.446116973356126,FALSE +"H2009","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.51467,-1.62,0.0626,8150,0.342,"TYMS, DHFR, ATIC, GART, MTHFD1, MTHFR",1.20342566678957,0.465973893943865,FALSE +"H2009","Input","KEGG_OOCYTE_MEIOSIS",-0.35419,-1.12,0.312,5425,0.467,"CCNB2, ANAPC4, PRKACB, ANAPC7, PKMYT1, PPP3CB, CDK2, MOS, PPP1CA, CDC25C, CDC23, RPS6KA1, FBXW11, ITPR2, YWHAH, ESPL1, CUL1, PRKACA, YWHAZ, PPP2R1A, MAD2L1, CCNB1, PPP3CC, PPP2CA, MAP2K1, YWHAE, PPP2R5C, CAMK2B, YWHAB, MAPK12, PPP2R1B, CDK1, FBXO5, MAPK1, PPP2R5B, YWHAQ, YWHAG, ADCY5, PPP2R5E, MAPK3, ADCY6, PPP2CB, STAG3, PPP2R5A, PPP2R5D, PTTG1",0.505845405981557,0.330683119433888,FALSE +"H2009","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.26005,0.826,0.654,301,0.722,"NEU1",0.184422251675733,0.141462802430361,FALSE +"H2009","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.087514,-0.285,1,5656,1,"ATP6V1G2, NDUFA6, NDUFC2, ATP6V0A1, NDUFB5, NDUFA9, COX7A2, ATP5F1A, NDUFA4, ATP6V0C, NDUFS7, ATP5F1C, ATP6V1C2, ATP6V1D, ATP5PB, ATP6V1E1, ATP6V1G1, NDUFAB1, ATP5MG, COX6C, ATP6V1H, ATP6V1B2, LHPP, ATP6V1B1, ATP6V1A, ATP6V1C1, PPA1",0,0,FALSE +"H2009","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.52575,1.71,0.0382,373,0.215,"GALNT3, GALNT6, GALNT12, GALNT13, GALNT15, GALNT7",1.41793663708829,0.667561540084395,TRUE +"H2009","Input","KEGG_P53_SIGNALING_PATHWAY",-0.36936,-1.2,0.207,7610,0.421,"CCND3, CASP8, CASP3, CDK1, PTEN, RRM2B, SIAH1, CDKN1A, APAF1, BAX, SESN2, DDB2, CDK6, TSC2, SERPINE1, RRM2, CCND1",0.684029654543082,0.375717904164332,FALSE +"H2009","Input","KEGG_PANCREATIC_CANCER",-0.27715,-0.88,0.577,7828,0.697,"PIK3R2, MAPK1, MAPK8, ARAF, SMAD2, RELA, AKT1, BRAF, TGFB3, MAPK3, PIK3CA, CDK6, PIK3R1, AKT2, IKBKB, RAF1, CCND1, RB1",0.238824186844269,0.156767221901991,FALSE +"H2009","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.62371,-1.96,0.0207,7354,0.33,"PPCDC, PANK2, PANK4, DPYD, PPCS",1.68402965454308,0.481486060122112,FALSE +"H2009","Input","KEGG_PARKINSONS_DISEASE",0.13281,0.435,1,3435,1,"SDHA, UBE2J1, UBE2G2, NDUFA8, UQCRH, SDHB, HTRA2, NDUFS6, UBE2J2, UQCRB, UQCRFS1, NDUFA7, NDUFB1, NDUFA2, NDUFV2, UQCRC1, VDAC1, NDUFS8, NDUFS4, NDUFS5, NDUFV3, LRRK2, NDUFB10, NDUFB8, VDAC2, NDUFA5, NDUFS1, UQCRC2, NDUFA3, NDUFV1, NDUFA10, NDUFB9, SDHD, COX5A, SLC25A5, COX7A2L, NDUFS3, SNCA, SLC25A4",0,0,FALSE +"H2009","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.50904,-1.67,0.0425,7773,0.368,"TUBB4B, ABL1, YWHAQ, ROCK2, TUBA1C, TUBB1, TUBB3, TUBB, TUBB6, TUBA3C, TUBA1B, TUBB2A, TUBAL3, TUBB2B, CLDN1, WAS",1.37161106994969,0.434152181326482,FALSE +"H2009","Input","KEGG_PATHWAYS_IN_CANCER",-0.22836,-0.731,0.8,7329,0.852,"MAP2K2, IKBKG, DVL3, CRKL, STAT5A, NFKB1, BIRC2, HGF, SOS1, PTK2, CASP8, CASP3, TRAF2, PTEN, ABL1, PIK3R2, PIAS2, MAPK1, MAPK8, CRK, HSP90AB1, EGLN1, ARAF, CDKN1A, CUL2, SMAD2, PDGFRA, HSP90AA1, BAX, RELA, PDGFRB, CBL, AKT1, BRAF, FADD, TGFB3, MAPK3, FGFR2, PIK3CA, NFKB2, TFG, CDK6, STK4, TRAF6, GSK3B, PIK3R1, GSTP1, DAPK1, AKT2, PLCG1, CEBPA, CBLB, IKBKB, CDKN1B, FOXO1, PIAS4, FGFR1, COL4A1, RAF1, CCND1, RB1, GLI3",0.0969100130080564,0.0695604052332999,FALSE +"H2009","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.48909,-1.59,0.0612,5337,0.359,"AKR1B1, UGT2B11, UGT2B4, DCXR, GUSB, UGP2, RPE, XYLB, CRYL1",1.21324857785444,0.444905551421681,FALSE +"H2009","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.57749,-1.89,0.0158,7160,0.318,"PRPS2, PGM2, ALDOA, RBKS, PGM1, PRPS1, PRPS1L1, RPE, PGLS, DERA, TALDO1, PGD, PFKP, GPI, PFKM, PFKL",1.80134291304558,0.497572880015567,FALSE +"H2009","Input","KEGG_PEROXISOME",0.30176,1.01,0.395,2320,0.536,"PIPOX, ACAA1, SLC25A17, ACOX1, PEX2, AGPS, PECR, PEX6, ABCD1, PEX26, ACSL4, PEX1, PEX13, ECI2, SCP2, ACSL3, FAR1, CROT, GSTK1, HSD17B4, HACL1, HMGCL, ACOT8",0.40340290437354,0.27083521030723,FALSE +"H2009","Input","KEGG_PHENYLALANINE_METABOLISM",-0.33871,-1.1,0.301,6402,0.449,"TAT, MAOB, DDC, MIF, PRDX6, NAA80, ALDH3A1",0.521433504406157,0.347753658996677,FALSE +"H2009","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.44934,-1.46,0.0919,6581,0.374,"PIP4K2B, PI4KB, CDIPT, INPP4A, PLCB3, IMPA2, PRKCB, DGKZ, PIK3CB, DGKA, PLCG2, INPP5B, PTEN, PIK3R2, DGKB, SYNJ1, PIK3C2B, OCRL, PIK3CA, IMPA1, ITPK1, PIK3R1, INPPL1, PIK3C3, PLCG1, PLCB4, INPP1, DGKH, PLCB2",1.03668448861389,0.42712839779952,FALSE +"H2009","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.29433,-0.925,0.494,7805,0.638,"BLVRB, CP, HMBS, UROD, BLVRA, UROS",0.306273051076353,0.195179321278838,FALSE +"H2009","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.36098,1.2,0.209,1984,0.423,"FADS2, CYP27A1, ACADM, MMP1, ACAA1, APOA1, ACOX1, CPT2, ACSL4, SORBS1, SLC27A4, SCP2, ACSL3, FABP2, RXRA, APOC3",0.679853713888946,0.373659632624958,FALSE +"H2009","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45448,1.51,0.0913,2446,0.248,"CYP27A1, SCP2, HSD17B4, AMACR",1.0395292224657,0.605548319173784,FALSE +"H2009","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.17553,0.583,0.962,933,1,"RFXAP, RFXANK",0.0168249279621871,0,FALSE +"H2009","Input","KEGG_PRION_DISEASES",-0.48858,-1.57,0.0628,6110,0.364,"PRNP, PRKACA, STIP1, NCAM2, MAP2K1, MAP2K2, C9, MAPK1, IL1A, BAX, MAPK3, SOD1, NCAM1",1.2020403562628,0.438898616350944,FALSE +"H2009","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.30465,-0.984,0.432,7495,0.592,"MAPK14, MAPK12, GNAI1, CDK1, PIK3R2, MAPK1, MAPK8, HSP90AB1, ARAF, ADCY5, HSP90AA1, AKT1, BRAF, MAPK3, ADCY6, PIK3CA, PIK3R1, AKT2, RAF1",0.364516253185088,0.22767829327708,FALSE +"H2009","Input","KEGG_PROPANOATE_METABOLISM",0.42598,1.37,0.142,2236,0.32,"ACADM, ALDH1B1, ACSS3, MCEE, ACAT1, ECHS1, HADHA, PCCB, SUCLG2, ALDH2, PCCA, SUCLG1, ALDH7A1",0.847711655616944,0.494850021680094,FALSE +"H2009","Input","KEGG_PROSTATE_CANCER",-0.41227,-1.32,0.151,7178,0.348,"MTOR, PIK3CB, CASP9, MAP2K2, IKBKG, NFKB1, SOS1, PTEN, PIK3R2, MAPK1, HSP90AB1, ARAF, CDKN1A, PDGFRA, HSP90AA1, RELA, PDGFRB, AKT1, BRAF, MAPK3, FGFR2, PIK3CA, GSK3B, PIK3R1, GSTP1, AKT2, IKBKB, CDKN1B, FOXO1, FGFR1, RAF1, CCND1, RB1",0.821023052706831,0.458420756053419,FALSE +"H2009","Input","KEGG_PROTEASOME",-0.20163,-0.661,0.898,2341,0.945,"PSMD4, PSME3, PSMB10, PSMB6, PSMC5, PSMB7, PSMC6, PSMC3, PSMC4, PSMA1, PSMC2, PSMD14, PSMA4, PSMB9, PSMB2, PSMB3, PSMB4, PSMC1, PSMA3, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB5, PSMA2, PSME4, PSMD2, PSMD11, PSMD6, PSMD7, PSMD13, PSMD1, PSMD8, SEM1, PSMD12, PSMD3, POMP, PSME1, PSME2, PSMF1",0.0467236633326956,0.0245681914907371,FALSE +"H2009","Input","KEGG_PROTEIN_EXPORT",-0.23798,-0.755,0.751,5254,0.856,"SEC63, SRP68, SRPRB, SPCS1, OXA1L, SRP14, SEC61B, SEC61A1, SRP19, SRP54, SEC11C",0.124360062995832,0.0675262353228468,FALSE +"H2009","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.39199,1.29,0.169,1189,0.374,"GLUD2, ATP1A2, ATP1B1, GLS, GLS2",0.772113295386326,0.42712839779952,FALSE +"H2009","Input","KEGG_PURINE_METABOLISM",-0.29485,-0.941,0.47,6958,0.619,"NT5C3A, GMPS, PKM, PRPS2, NUDT9, GUCY1A1, NT5C2, DCK, GMPR2, PDE5A, PDE2A, NT5C, PAICS, PNP, PRPS1, PRPS1L1, PDE8A, XDH, RRM2B, HPRT1, IMPDH2, ADCY5, PKLR, NME3, ADSL, ADCY6, ATIC, NME1, APRT, NUDT5, GART, ADA, AMPD2, ITPA, RRM2, PFAS, RRM1, NUDT2",0.327902142064283,0.208309350979882,FALSE +"H2009","Input","KEGG_PYRIMIDINE_METABOLISM",-0.23517,-0.749,0.755,7236,0.84,"NT5C2, DCK, UPP1, NT5C, DPYD, PNP, DUT, CTPS2, RRM2B, TYMS, DCTD, NME3, CAD, UPRT, NME1, UMPS, CTPS1, ITPA, RRM2, RRM1, NUDT2",0.122053048370812,0.0757207139381184,FALSE +"H2009","Input","KEGG_PYRUVATE_METABOLISM",-0.22973,-0.75,0.759,6465,0.847,"HAGHL, ACSS1, ACACA, GRHPR, PKM, HAGH, ACACB, ACAT2, ACYP1, LDHA, PCK2, MDH1, PKLR, ACSS2",0.11975822410452,0.0721165896692931,FALSE +"H2009","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.23404,-0.751,0.784,6428,0.854,"ARPC4, ACTG1, ARHGEF6, GIT1, IQGAP1, PIP4K2B, ARPC1A, ITGA1, VAV3, MSN, CFL1, WASL, SSH1, DIAPH1, MAP2K1, ARHGEF7, PAK3, MYH14, ROCK1, PXN, PIK3CB, CYFIP2, F2R, PAK2, MAP2K2, CRKL, LIMK2, IQGAP3, MYH10, SOS1, PTK2, ARHGEF1, MYH9, CYFIP1, PIK3R2, MAPK1, VAV2, GNA12, CRK, ROCK2, ARAF, PDGFRA, ITGB3, PFN1, PDGFRB, BRAF, MAPK3, DIAPH3, FGFR2, VCL, PIK3CA, SSH3, ARHGAP35, PIK3R1, DOCK1, GNA13, CSK, FGFR1, RAF1, WAS",0.105683937315562,0.068542129310995,FALSE +"H2009","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.62889,-2.03,0.00888,8159,0.302,"ATG7, ATG4B, PRKAA1, PIK3R4, PIK3C3, ATG3",2.0515870342214,0.519993057042849,FALSE +"H2009","Input","KEGG_RENAL_CELL_CARCINOMA",-0.3157,-1.01,0.391,6980,0.565,"MAP2K1, PAK3, RAPGEF1, PIK3CB, PAK2, MAP2K2, CRKL, HGF, SOS1, PIK3R2, MAPK1, CRK, EGLN1, FLCN, ARAF, CUL2, AKT1, BRAF, TGFB3, MAPK3, PTPN11, PIK3CA, PIK3R1, AKT2, RAF1",0.407823242604133,0.247951552180562,FALSE +"H2009","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.58364,-1.91,0.0187,8618,0.338,"MME, ACE, CTSG, ACE2",1.7281583934635,0.471083299722345,FALSE +"H2009","Input","KEGG_RETINOL_METABOLISM",-0.38306,-1.24,0.201,9074,0.414,"ADH5, ALDH1A1",0.696803942579511,0.382999658879101,FALSE +"H2009","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.35905,-1.14,0.268,6823,0.474,"ACP2, RFK, ACP1, PHPT1, MTMR2, MTMR6",0.571865205971211,0.324221658325915,FALSE +"H2009","Input","KEGG_RIBOSOME",-0.6532,-2.09,0.00708,6319,0.451,"RPL35, RPLP0, RPS4Y1, RPL23, RPL22L1, RPS15A, RPL23A, RPL36, RPL24, RSL24D1, RPL22, RPS7, RPL3, RPS19, RPL17, RPS8, RPL10, RPL15, RPS6, RPS15, RPL5, RPS4X, RPL7, RPS20, RPL30, RPS17, RPL31, RPS3, RPS24, RPS3A, RPL18A, RPL9, RPL27A, RPS25, RPS26, RPL35A, RPS5, RPL10A, RPL27, RPS13, RPL8, RPL4, RPL37A, RPL18, RPL21, RPL26, RPS2, RPL32, RPL29, RPS16, RPL6, RPL7A, RPL13A, RPL14, RPL28, RPS9, RPL37, RPS10, RPS18, RPL34, UBA52, RPL19, RPS11, FAU, RPS27L, RPS23, RPL36A, RPL36AL, RPL38, RPL26L1",2.14996674231023,0.345823458122039,FALSE +"H2009","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.55481,-1.75,0.0371,6379,0.385,"ATG5, MAPK9, MAVS, TRAF3, MAP3K7, TRIM25, MAPK10, NFKBIB, DHX58, IKBKG, TBKBP1, NFKB1, MAPK14, MAPK12, CASP8, TANK, TRAF2, IRF3, MAPK8, DDX58, RIPK1, TBK1, RELA, FADD, PIN1, DDX3Y, TRAF6, CYLD, IKBKB, TKFC",1.43062609038495,0.414539270491499,FALSE +"H2009","Input","KEGG_RNA_DEGRADATION",-0.17392,-0.56,0.976,6984,0.986,"CNOT4, CNOT6L, XRN1, CNOT7, XRN2, DCP2, DIS3, ENO1, PATL1, LSM1, ENO3, TTC37, SKIV2L, DCP1B",0.0105501823333082,0.0061230850587888,FALSE +"H2009","Input","KEGG_RNA_POLYMERASE",0.4584,1.51,0.0953,3369,0.248,"POLR2D, POLR2L, POLR1E, POLR2I, POLR2K, POLR2G, POLR3K, POLR2J, POLR2C, POLR2F, POLR2E, POLR3H, POLR3F, POLR3D, POLR1C, POLR1D, POLR2A, POLR2H",1.02090709936167,0.605548319173784,FALSE +"H2009","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.38989,-1.25,0.202,5400,0.409,"MAT2B, GGT1, TRMT11, SEPHS2, AHCYL1, AHCYL2, PAPSS2, MAT2A, BUD23, METTL2B, CTH, SCLY, MAT1A, LCMT1, AHCY, CBS, LCMT2",0.694648630553376,0.388276691992658,FALSE +"H2009","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.31011,1.02,0.372,586,0.531,"LAMC2, TP53, ITGA2B, LAMB3, ITGA6, ITGA3, LAMA3, LAMA4, PIK3R3, ITGA2, LAMB1, ITGAV",0.429457060118102,0.274905478918531,FALSE +"H2009","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.29441,0.958,0.432,2020,0.548,"VAMP8, GOSR1, STX17, VAMP4, STX10, STX6, GOSR2, STX12",0.364516253185088,0.261219441515631,FALSE +"H2009","Input","KEGG_SPHINGOLIPID_METABOLISM",0.48509,1.67,0.044,483,0.214,"PLPP2, NEU1, UGT8, PLPP3, GLA",1.35654732351381,0.669586226650809,TRUE +"H2009","Input","KEGG_SPLICEOSOME",0.5245,1.68,0.0628,2839,0.219,"ISY1, PHF5A, HNRNPA3, SNRNP70, SRSF1, SNRPB, PRPF4, PRPF40B, SF3B4, HNRNPC, SNRPC, U2AF1, PPIE, SNRPG, U2AF2, SRSF9, NCBP2, SNRPD3, TRA2A, SF3B5, SNRPF, DHX8, TCERG1, PUF60, THOC3, SRSF10, RBM25, SRSF3, SF3B2, PRPF40A, SRSF7, LSM8, SRSF8, PRPF3, DDX5, LSM4, SF3B6, RBMX, TRA2B, LSM6, SNRPA1, SNRPA, HNRNPA1, SRSF4, SF3A1, HNRNPK, DDX23, SF3B1, SRSF5, BCAS2, U2SURP, DDX46, SRSF6, LSM7, DHX38, PPIH, ALYREF, DDX42, PRPF19, ZMAT2, RBM17, RBM8A, SNRNP40, PQBP1, SNRPB2, THOC1, LSM2, HSPA1L, SF3A3, SRSF2, PRPF38A, SNW1, SF3B3",1.2020403562628,0.659555885159882,FALSE +"H2009","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.389,-1.23,0.215,5667,0.404,"UGT2B11, UGT2B4, PYGB, GUSB, AGL, PYGL, UGP2, GCK, HK3, PGM2, PGM1, GYS1, GBE1, GPI",0.667561540084395,0.393618634889395,FALSE +"H2009","Input","KEGG_STEROID_BIOSYNTHESIS",0.4863,1.62,0.0394,1862,0.223,"MSMO1, SOAT1, FDFT1, HSD17B7, SQLE, CYP27B1, DHCR24, NSDHL",1.40450377817443,0.651695136951839,TRUE +"H2009","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.34609,-1.12,0.288,7659,0.467,"AKR1C1, AKR1C3, AKR1D1, CYP21A2",0.540607512240769,0.330683119433888,FALSE +"H2009","Input","KEGG_SULFUR_METABOLISM",0.47416,1.56,0.0818,2177,0.232,"CHST11, SULT1A3, CHST12, PAPSS1",1.08724669632868,0.6345120151091,FALSE +"H2009","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.27638,-0.887,0.583,7154,0.7,"C3, C9, C4A, TRIM21, CTSG",0.234331445240986,0.154901959985743,FALSE +"H2009","Input","KEGG_TASTE_TRANSDUCTION",-0.3025,-0.954,0.462,8567,0.619,"ADCY6, PLCB2",0.335358024443874,0.208309350979882,FALSE +"H2009","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.47856,-1.55,0.0698,6679,0.355,"FDPS, PMVK, MVK, ACAT2, IDI1, MVD, GGPS1",1.15614457737684,0.449771646944906,FALSE +"H2009","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.32172,-1.04,0.375,6779,0.524,"ZFYVE16, BMPR2, PPP2CA, ROCK1, RPS6KB1, ID3, AMH, RPS6KB2, PPP2R1B, MAPK1, ROCK2, SMAD2, SMAD5, SMAD9, SMAD1, TGFB3, MAPK3, PPP2CB",0.425968732272281,0.280668713016273,FALSE +"H2009","Input","KEGG_THYROID_CANCER",0.38556,1.27,0.183,1410,0.385,"TP53, CTNNB1, CDH1, HRAS, KRAS, NRAS, NCOA4, TPR, MYC",0.737548910269571,0.414539270491499,FALSE +"H2009","Input","KEGG_TIGHT_JUNCTION",0.30393,0.995,0.407,1297,0.529,"CLDN7, CGN, F11R, CTNNB1, AMOTL1, CTNNA1, TJP3, CTNNA2, CASK, MYH2, MPDZ, PATJ, HRAS, TJP1, VAPA, SPTAN1, ACTN4, KRAS, NRAS, LLGL2, TJP2, AFDN, RAB3B, ASH1L",0.39040559077478,0.276544327964814,FALSE +"H2009","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.48209,-1.54,0.0848,6703,0.351,"STAT1, TRAF3, MAP3K7, SPP1, MAP2K1, MAPK10, IRAK4, PIK3CB, MAP2K2, IKBKG, NFKB1, MAPK14, MAPK12, MAP2K7, CASP8, IRF3, PIK3R2, MAPK1, MAPK8, MAP2K4, MYD88, RIPK1, TBK1, RELA, AKT1, FADD, MAPK3, PIK3CA, TAB2, TRAF6, PIK3R1, AKT2, IKBKB, MAP2K3",1.07160414774329,0.454692883534176,FALSE +"H2009","Input","KEGG_TRYPTOPHAN_METABOLISM",0.32458,1.09,0.293,1258,0.498,"ALDH1B1, MAOA, ACAT1, ECHS1, HADH, HADHA",0.533132379645891,0.302770657240282,FALSE +"H2009","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.44209,-1.39,0.116,6930,0.344,"GCK, PKM, MAPK10, MTOR, HK3, PIK3CB, PIK3R2, MAPK1, MAPK8, PRKCZ, PKLR, MAPK3, PIK3CA, PIK3R1, SOCS2, IKBKB",0.935542010773082,0.46344155742847,FALSE +"H2009","Input","KEGG_TYROSINE_METABOLISM",-0.52439,-1.66,0.0368,6402,0.334,"TAT, MAOB, FAH, BUD23, METTL2B, DDC, DCT, MIF, PNMT, LCMT1, NAA80, ALDH3A1, GSTZ1, ADH5, LCMT2",1.43415218132648,0.476253533188435,FALSE +"H2009","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.43728,-1.42,0.125,6633,0.371,"BCL10, VAV3, PPP3CC, PTPN6, MAP3K7, NCK2, MAP2K1, PAK3, PIK3CB, NFKBIB, PAK2, MAP2K2, NCK1, IKBKG, PRKCQ, NFKB1, MAPK14, MAPK12, SOS1, MAP2K7, NFATC2, PIK3R2, MAPK1, VAV2, NFKBIE, RELA, CBL, AKT1, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, PLCG1, MALT1, CBLB, IKBKB, RAF1",0.903089986991944,0.430626090384954,FALSE +"H2009","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.3559,-1.13,0.291,7777,0.482,"UBE2O, PIAS2, UBE2M, CDC34, UBE2L3, SIAH1, FBXW8, CUL2, BIRC6, NEDD4L, CUL7, UBE2R2, UBE2G1, NEDD4, CBL, HERC1, UBE2D2, UBE2N, DDB2, UBE3C, UBE2E1, UBE2D4, UBA1, TRAF6, UBE2NL, HERC4, UBE3B, CBLB, UBE3A, PIAS4",0.536107011014093,0.31695296176115,FALSE +"H2009","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.48592,1.56,0.078,1659,0.232,"PDHA1, PDHB, BCAT2",1.10790539730952,0.6345120151091,FALSE +"H2009","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.58129,1.91,0.0111,2597,0.21,"ACADM, ALDH1B1, OXCT1, ACAA1, DBT, MCEE, ACAT1, ECHS1, HADHB, HADH, HADHA, MCCC2, PCCB, ACADSB, BCAT2, ALDH2, PCCA, AUH, ALDH7A1, BCKDHA, HMGCL, BCKDHB, ALDH3A2",1.95467702121334,0.677780705266081,TRUE +"H2009","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.46886,-1.48,0.0945,5982,0.364,"ARHGEF11, ITPR2, PRKCD, PRKG1, MYL6, ARHGEF12, GNAS, PRKACA, PRKCA, PLCB3, MAP2K1, PRKCB, ROCK1, GUCY1A1, MAP2K2, PRKCQ, ARHGEF1, MAPK1, GNA12, ROCK2, ARAF, MYH11, ADCY5, BRAF, KCNMA1, MAPK3, ADCY6, CALD1, PLCB4, GNA13, PLCB2, RAF1",1.02456819149074,0.438898616350944,FALSE +"H2009","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.35698,-1.15,0.267,7018,0.468,"DYNC2LI1, DCTN4, DCTN5, DCTN6, ARHGDIA, DCTN2, DYNC1LI2, DCTN1, DYNC1I2, ADCY6, DYNC1LI1, DYNC1H1",0.573488738635425,0.329754146925876,FALSE +"H2009","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.30473,-0.98,0.433,6980,0.591,"MAP2K1, PRKCB, PXN, PIK3CB, CASP9, PLCG2, MAP2K2, HSPB1, MAPK14, MAPK12, PTK2, NFATC2, PIK3R2, MAPK1, MAPKAPK2, AKT1, MAPK3, PIK3CA, PIK3R1, AKT2, PLCG1, RAF1",0.363512103646635,0.228412519118745,FALSE +"H2009","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.37068,-1.23,0.184,6251,0.404,"GNAS, ATP6V0C, PRKACA, PRKCA, ACTG1, SEC61B, ATP6V1C2, ATP6V1D, SEC61A1, SLC12A2, PRKCB, ATP6V1E1, ATP6V1G1, PLCG2, ATP6V1H, ATP6V1B2, ATP6V1B1, ATP6V1A, ATP6V1C1, PLCG1",0.735182176990464,0.393618634889395,FALSE +"H2009","Input","KEGG_VIRAL_MYOCARDITIS",0.30864,1.03,0.346,425,0.526,"ITGB2, RAC2, CD55, MYH2",0.460923901207223,0.279014255846261,FALSE +"H2009","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.18723,-0.605,0.949,6125,0.976,"WNT5A, DVL2, SMAD4, CUL1, PRKACA, PRKCA, NFAT5, CSNK2A1, CSNK2A2, MAPK9, PPP2R1A, PPP3CC, MAP3K7, PLCB3, PPP2CA, MAPK10, PRKCB, CACYBP, ROCK1, PPP2R5C, CAMK2B, DVL3, PPP2R1B, CCND3, NFATC2, PPP2R5B, MAPK8, ROCK2, SIAH1, SMAD2, PPP2R5E, PPP2CB, NLK, PPP2R5A, GSK3B, PPP2R5D, PLCB4, PLCB2, CCND1",0.0227337875727074,0.0105501823333082,FALSE +"H2126","Input","KEGG_ABC_TRANSPORTERS",0.59912,1.72,0.0387,1103,0.206,"ABCG2, ABCB6, ABCD1, ABCC3, ABCC2, ABCB8",1.41228903498109,0.686132779630847,TRUE +"H2126","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.22995,-0.706,0.837,7987,0.999,"TCF7L2, MYC, CCND1, PIK3R3, PML",0.07727454200674,0.000434511774017692,FALSE +"H2126","Input","KEGG_ADHERENS_JUNCTION",0.25036,0.728,0.789,1346,1,"NECTIN4, LMO7, PTPRM, CDH1, RAC2, WASL, CTNNA1, PTPRF, TGFBR1, IQGAP1, CTNNA2, RAC3",0.10292299679058,0,FALSE +"H2126","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.51611,1.49,0.0841,2311,0.331,"PRKAB2, PRKAB1, PRKAG1, ACSL1, PRKAA1, ADIPOR1, PRKAG2, ACSL3, IRS2, NFKBIB, PRKAA2, CPT1A, IKBKG, SLC2A1, IKBKB, TRAF2, ACSL5, ACACB, ACSL6, AKT1, RELA, MTOR, CHUK, RXRG, RXRA",1.07520400420209,0.480172006224281,FALSE +"H2126","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.32409,-0.98,0.424,8469,0.823,"GFPT2, GLS, GLS2, DDO",0.372634143407267,0.0846001647877302,FALSE +"H2126","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.20958,-0.64,0.936,7781,1,"PRKCB, IRS1, PIK3R3",0.0287241512618947,0,FALSE +"H2126","Input","KEGG_ALZHEIMERS_DISEASE",0.25428,0.75,0.796,2827,1,"ATP2A3, ITPR1, CASP9, NDUFA2, BID, UQCRH, EIF2AK3, CACNA1F, CAPN2, CYC1, CDK5, PSEN2, UQCR10, IDE, SNCA, CHP1, NDUFB1, NDUFAB1, ATP2A2, NDUFA9, MAPK3, UQCRQ, NDUFC2, ATP5MC2, NDUFB7, CYCS, NDUFV2, NDUFS6, UQCRB, NDUFA5, NDUFB6, PSEN1, CASP7, FAS, NDUFA7, NDUFC1, CASP3, NDUFS4",0.0990869322623309,0,FALSE +"H2126","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.21908,0.637,0.93,1725,1,"TARS2, NARS2, SEPSECS, VARS2, PARS2",0.0315170514460649,0,FALSE +"H2126","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.51946,1.49,0.0913,2147,0.331,"GNPNAT1, FPGT, GFPT1, GNPDA2, GALK2, NANS, PMM2, GNE, UGDH, PGM3, UXS1, GMDS, HK1, PGM2, PGM1, PMM1, MPI, GMPPA, GALE, CYB5R3, AMDHD2, NAGK, CYB5R1",1.0395292224657,0.480172006224281,FALSE +"H2126","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.32373,-1.02,0.372,7922,0.784,"NEFH, PRPH, PRPH2, GRIN1, BCL2L1, MAP2K6, TOMM40L, CASP1, TP53, GPX1",0.429457060118102,0.105683937315562,FALSE +"H2126","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.24207,-0.73,0.779,7492,1,"RFXANK, HSPA4, RFX5, CD74, TAP1, CTSS, CTSB",0.108462542327436,0,FALSE +"H2126","Input","KEGG_APOPTOSIS",0.22094,0.645,0.904,2238,1,"CASP9, MYD88, BID, CAPN2, BIRC2, BAX, AIFM1, IKBKG, XIAP, CHP1, IKBKB, TRAF2, AKT1, IRAK4, RELA, ENDOG, CYCS, CHUK",0.0438315695246367,0,FALSE +"H2126","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.5093,1.48,0.0915,812,0.314,"PTGES, PLA2G12A, PLA2G4A, GPX2, LTA4H",1.03857890593355,0.503070351926785,FALSE +"H2126","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.33614,0.979,0.439,989,0.723,"AGMAT, GLUL, CKMT1A, PYCR1, CKMT2, GAMT, CPS1, GATM, OAT, ODC1, SRM, ALDH18A1",0.357535479757879,0.140861702705469,FALSE +"H2126","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.53299,-1.63,0.0472,7855,0.655,"LAMA2, TCF7L2, ITGB8, CACNA2D2, ITGA2B, ITGA2, DSC2, ITGA6, ACTN1, LMNA, ITGA10, ITGB4, ACTG1, SGCB, CDH2, ITGB3, GJA1, CACNA2D1",1.32605800136591,0.183758700008217,FALSE +"H2126","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.37229,-1.13,0.26,7617,0.707,"ALDH1B1, ALDH9A1",0.585026652029182,0.150580586203101,FALSE +"H2126","Input","KEGG_AXON_GUIDANCE",-0.42414,-1.29,0.175,7255,0.661,"ROBO1, EFNA5, ABLIM1, SEMA4B, PAK3, SRGAP2, SRGAP3, EPHA7, DPYSL5, PLXNA1, ABLIM2, CXCR4, CFL2, GNAI1, EPHB3, PLXNA2, ABLIM3, PAK2, EPHB2, NFAT5, EPHA2, EPHA6, EPHA5, SEMA3A, DPYSL2, EFNB1, EPHA4, PLXNB3, NFATC2, EFNB2, SEMA5A",0.756961951313706,0.17979854051436,FALSE +"H2126","Input","KEGG_BASAL_CELL_CARCINOMA",-0.6756,-2.11,0.012,7503,0.364,"WNT5A, SUFU, FZD1, TCF7L2, GLI2, GLI3, FZD7, TP53",1.92081875395238,0.438898616350944,FALSE +"H2126","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.54803,-1.68,0.0535,5616,0.749,"GTF2F1, GTF2E1, GTF2E2, GTF2IRD1, TAF5, TAF4, GTF2F2, TAF9, TAF6L, GTF2I, GTF2A1, TAF7, GTF2H2, TAF5L, GTF2H1, GTF2B, GTF2A2",1.27164621797877,0.125518182300534,FALSE +"H2126","Input","KEGG_BASE_EXCISION_REPAIR",-0.16099,-0.484,0.994,6400,1,"POLD3, MBD4, POLL, POLE3, POLD2, LIG1, FEN1, POLD1, POLE, POLE2",0.00261361560268669,0,FALSE +"H2126","Input","KEGG_BETA_ALANINE_METABOLISM",0.31702,0.903,0.534,900,0.815,"ACADM, SRM",0.272458742971444,0.0888423912600234,FALSE +"H2126","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.35363,1.02,0.409,2304,0.693,"ACOX3, HACD1, ELOVL5, ACAA1, ACOT2, SCD, FADS2, ACOT1, TECR",0.388276691992658,0.159266765388193,FALSE +"H2126","Input","KEGG_BLADDER_CANCER",-0.40679,-1.25,0.194,7877,0.687,"DAPK1, MMP1, MYC, CCND1, CDKN2A, TP53, THBS1",0.712198270069774,0.16304326294045,FALSE +"H2126","Input","KEGG_BUTANOATE_METABOLISM",-0.52691,-1.59,0.0714,7606,0.549,"ALDH5A1, ALDH1B1, BDH1, ALDH9A1, BDH2, HMGCS2, ACSM3, OXCT1",1.14630178822383,0.260427655549908,FALSE +"H2126","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.24858,-0.751,0.77,7781,1,"PRKCB, CARD11, BTK, LYN, NFAT5, JUN, PIK3R3, NFATC2, CD79A",0.113509274827518,0,FALSE +"H2126","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2744,0.79,0.72,2265,0.985,"ATP2A3, ITPR1, CACNA1A, CD38, PHKA1, ATP2B1, SLC25A5, CACNA1F, VDAC2, LTB4R2, P2RX4, GNA11, PHKB, CHP1, ERBB3, ATP2A2, PHKG2, HRH1, SLC25A31, PHKA2, TACR1, SLC25A6, PPID, SPHK2",0.142667503568732,0.00656376950238827,FALSE +"H2126","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.2875,-0.879,0.544,7402,0.933,"COX6B1, COX7C, TPM2, CACNA2D2, COX6A1, COX7A2, CACNA2D1",0.26440110030182,0.0301183562535,FALSE +"H2126","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.31486,0.91,0.523,449,0.814,"CLDN3, CDH5, CLDN7, PTPRM, CD40, ITGB2, CDH1",0.281498311132726,0.0893755951107988,FALSE +"H2126","Input","KEGG_CELL_CYCLE",-0.29725,-0.915,0.491,6666,0.931,"SMC1A, PRKDC, WEE1, CDK4, CREBBP, SMAD4, E2F3, PLK1, RBL1, MCM2, RAD21, SMC1B, CCNA2, MAD2L1, SMC3, HDAC1, MCM7, MCM6, SMAD3, MCM3, CDKN2D, ORC6, MAD1L1, CDC25C, MCM4, MYC, ATR, PTTG1, CCND1, TGFB2, CDKN2A, TP53, CDK6, CDKN2C",0.308918507877032,0.0310503190186574,FALSE +"H2126","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.17888,-0.539,0.986,7139,1,"PLCB2, PLCB3, PREX1, VAV1, ELMO1, GRK6, CXCR4, PRKCB, GNB4, GNAI1, CXCL5, LYN, ADCY3, ADCY8, WAS, GNG7, CCL5, PIK3R3, GNG4",0.0061230850587888,0,FALSE +"H2126","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.37521,-1.19,0.231,6791,0.608,"CDK4, NFKB1, SMAD4, E2F3, CTBP2, RUNX1, HDAC1, BAD, SMAD3, TGFBR2, BCL2L1, MYC, CCND1, TGFB2, MECOM, CDKN2A, GAB2, TP53, CDK6, PIK3R3",0.636388020107856,0.216096420727265,FALSE +"H2126","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.67963,1.95,0.00905,862,0.197,"BHLHE41, PER2, CSNK1E",2.0433514207948,0.705533773838407,TRUE +"H2126","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.26045,0.748,0.775,2193,1,"ACLY, IDH2, DLAT, MDH2, IDH1, SUCLG2, DLST, DLD",0.11069829749369,0,FALSE +"H2126","Input","KEGG_COLORECTAL_CANCER",-0.26635,-0.823,0.627,7455,1,"BAD, APPL1, SMAD3, TCF7L2, TGFBR2, MYC, CCND1, TGFB2, JUN, TP53, PIK3R3",0.202732459169284,0,FALSE +"H2126","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.47122,1.38,0.122,256,0.368,"FGA, FGG, TFPI, FGB, MASP1, PLAUR",0.913640169325252,0.434152181326482,FALSE +"H2126","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.28799,0.842,0.648,2023,0.905,"CTH, ENOPH1, LDHA, SRM, ADI1, GOT1, AHCYL1, TAT",0.188424994129407,0.0433514207947967,FALSE +"H2126","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.38952,-1.19,0.207,7335,0.608,"IL1RAP, BMPR2, TNFRSF10A, CXCR4, PLEKHO2, TNFRSF21, ACVR2A, CXCL5, CD70, TGFBR2, IFNAR1, TNFRSF10D, IL6ST, TGFB2, TNFRSF10B, CCL5, INHBA, NGFR",0.684029654543082,0.216096420727265,FALSE +"H2126","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.2747,-0.822,0.635,8380,0.99,"ZBP1, TREX1, CASP1, CCL5",0.197226274708024,0.00436480540245009,FALSE +"H2126","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.47591,-1.46,0.102,7835,0.532,"TPM2, LAMA2, ITGB8, CACNA2D2, ADCY3, ADCY8, ITGA2B, ITGA2, TGFB2, ITGA6, LMNA, ITGA10, ITGB4, ACTG1, SGCB, ITGB3, CACNA2D1",0.991399828238082,0.274088367704952,FALSE +"H2126","Input","KEGG_DNA_REPLICATION",-0.41424,-1.29,0.164,6307,0.661,"POLA2, POLD3, RPA3, POLE3, POLD2, POLA1, MCM2, LIG1, FEN1, PRIM2, MCM7, POLD1, MCM6, POLE, MCM3, POLE2, MCM4",0.785156151952302,0.17979854051436,FALSE +"H2126","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.23097,-0.723,0.811,7978,1,"NOTCH2, NOTCH1",0.090979145788844,0,FALSE +"H2126","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.46523,1.38,0.115,487,0.368,"ALDH3B1, GSTM3, GSTK1, MGST2, MGST1, ALDH1A3, GSTZ1",0.939302159646388,0.434152181326482,FALSE +"H2126","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.31743,0.922,0.54,929,0.802,"CDA, CES1, CES2, TYMP, TPMT",0.267606240177031,0.0958256317158365,FALSE +"H2126","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.55437,-1.71,0.0514,7522,0.813,"ITGA3, COL5A1, COL5A2, LAMB3, SPP1, COL1A1, LAMC2, LAMA2, COL4A2, CD47, COL6A1, LAMB2, LAMC1, ITGB8, HMMR, COL1A2, ITGA2B, FN1, ITGA2, ITGA6, ITGA10, ITGB4, THBS1, ITGB3, THBS2, COL6A2, COL4A1",1.28903688100472,0.0899094544059319,FALSE +"H2126","Input","KEGG_ENDOCYTOSIS",0.30537,0.894,0.592,2973,0.821,"ARRB1, CHMP2A, ARFGAP1, ARFGAP3, USP8, DAB2, CHMP2B, HSPA2, PIKFYVE, RAB31, ARRB2, PSD, RAB11FIP4, SMURF1, ACAP1, VPS37C, CHMP5, RAB11A, ASAP2, STAM2, CHMP4A, CHMP4B, CHMP1B, PIP5K1C, VPS25, PLD2, ERBB3, VPS45, EHD1, AP2A1, SNF8, RAB22A, NEDD4, PLD1, CHMP4C, CLTC, RAB11B, HSPA1L, SH3GL1, CDC42, ITCH, AP2M1, SMAP1, HSPA6, CHMP3, HSPA1A, RAB5B, DNAJC6, VPS37A, CBL, STAMBP, EGFR, VPS36",0.22767829327708,0.0856568428805592,FALSE +"H2126","Input","KEGG_ENDOMETRIAL_CANCER",-0.20567,-0.622,0.941,7987,1,"TCF7L2, MYC, CCND1, TP53, PIK3R3",0.0264103765727431,0,FALSE +"H2126","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.22622,-0.687,0.816,8136,1,"LYN, ATP6V1B2, JUN, CCL5, HBEGF, PTPRZ1",0.0883098412461389,0,FALSE +"H2126","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.25997,-0.818,0.681,6992,0.983,"NCK1, PAK1, CAMK2D, PAK3, PLCG2, BAD, PRKCB, CAMK2B, MYC, PAK2, JUN, HBEGF, NRG1, PIK3R3, CAMK2G",0.166852888087215,0.00744648216786438,FALSE +"H2126","Input","KEGG_ETHER_LIPID_METABOLISM",0.50907,1.48,0.0887,2183,0.314,"PLA2G12A, PLA2G4A, PAFAH2, PLPP3, PLD2, PLD1, PAFAH1B3, PLA2G7",1.05207638016827,0.503070351926785,FALSE +"H2126","Input","KEGG_FATTY_ACID_METABOLISM",-0.27864,-0.855,0.581,7617,0.96,"ALDH1B1, ADH4, ADH7, ACADSB, ADH1C, ALDH9A1, ACAA2, GCDH, ECI1, ACSL4",0.235823867609669,0.0177287669604316,FALSE +"H2126","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.2122,0.609,0.949,2447,1,"PLA2G12A, PLA2G4A, RAC2, PRKCD, VAV2, RAC3, MAPK13, RAC1, AKT1, MAPK3, GRB2, PDPK1, MAPK12, SOS1",0.0227337875727074,0,FALSE +"H2126","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.22441,-0.69,0.865,8136,1,"LYN, ARPC1A, PTPRC, SCIN, WAS, ASAP3, PLPP1, GAB2, WASF1, PIK3R3",0.0629838925351858,0,FALSE +"H2126","Input","KEGG_FOCAL_ADHESION",-0.35199,-1.08,0.286,7522,0.738,"ITGA3, COL5A1, COL5A2, LAMB3, SPP1, COL1A1, PRKCB, LAMC2, LAMA2, COL4A2, COL6A1, LAMB2, LAMC1, ITGB8, COL1A2, PAK2, ITGA2B, CCND1, FLNA, FN1, ITGA2, ITGA6, JUN, ACTN1, CAV1, FLNC, ITGA10, ITGB4, THBS1, PIK3R3, ACTG1, MYLK, ITGB3, THBS2, COL6A2, COL4A1",0.543633966870957,0.131943638176958,FALSE +"H2126","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.51847,-1.61,0.0682,8658,0.564,"ALPI, ALPP, ALPG",1.16621562534352,0.248720896016658,FALSE +"H2126","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.5654,1.62,0.0592,1756,0.249,"FBP1, ALDOB, PHPT1, FPGT, FBP2, PFKFB4, PMM2, GMDS, HK1, AKR1B1, PMM1, MPI, GMPPA, SORD",1.22767829327708,0.603800652904264,FALSE +"H2126","Input","KEGG_GALACTOSE_METABOLISM",0.33023,0.959,0.466,2577,0.75,"GALK2, B4GALT1, HK1, PGM2, AKR1B1, PGM1, GALE, PFKP, HK2, GALK1",0.33161408331,0.1249387366083,FALSE +"H2126","Input","KEGG_GAP_JUNCTION",-0.22428,-0.68,0.861,7005,1,"GNAS, PLCB2, PLCB3, CSNK1D, TUBA4A, PRKCB, GNAI1, ITPR3, TUBB4A, ADCY3, ADCY8, GJA1",0.0649968485463452,0,FALSE +"H2126","Input","KEGG_GLIOMA",-0.38925,-1.19,0.224,8123,0.608,"CAMK2B, CCND1, CDKN2A, TP53, CDK6, PIK3R3, CAMK2G",0.649751981665837,0.216096420727265,FALSE +"H2126","Input","KEGG_GLUTATHIONE_METABOLISM",0.50785,1.47,0.101,1457,0.311,"GSTM3, GSTK1, MGST2, MGST1, G6PD, TXNDC12, GPX2, GSTZ1, RRM2, IDH2, ODC1, SRM, MGST3, IDH1, RRM1",0.995678626217357,0.507239610973163,FALSE +"H2126","Input","KEGG_GLYCEROLIPID_METABOLISM",0.28383,0.818,0.666,1849,0.942,"GK2, AKR1A1, DGAT1, AKR1B1, PLPP3, DGKE, AGK, GPAT4, MGLL",0.176525770829699,0.0259490972071227,FALSE +"H2126","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40749,1.16,0.26,2154,0.561,"LPGAT1, PLA2G12A, PEMT, PLA2G4A, CDS1, MBOAT7, PTDSS2, PISD, PLPP3, DGKE, LYPLA2, PLD2, GPAT4, LPCAT3, PLD1, PTDSS1, GPAM",0.585026652029182,0.251037138743839,FALSE +"H2126","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.37929,1.09,0.302,675,0.607,"CTH, GAMT, GATM, GLDC, GCAT",0.519993057042849,0.216811308924742,FALSE +"H2126","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.36834,1.06,0.348,1343,0.625,"FBP1, ALDOB, ALDH3B1, ALDH1A3, FBP2, GALM, AKR1A1, ACSS2, LDHA, DLAT, HK1, PGK1, BPGM, PGM2, PGM1",0.458420756053419,0.204119982655925,FALSE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.34847,1.01,0.43,1989,0.7,"B3GAT3, CHPF2, CHST12, B4GALT7",0.366531544420413,0.154901959985743,FALSE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.3983,1.14,0.269,1989,0.568,"HS6ST2, B3GAT3, EXT1, B4GALT7",0.570247719997592,0.245651664288981,FALSE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.70892,2.05,0.00916,652,0.141,"ST3GAL2, ST3GAL1, B4GALT4, B4GALT1",2.03810452633215,0.85078088734462,TRUE +"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.69667,-2.15,0.00888,8038,0.575,"GLB1, ARSB, HEXB, HEXA, SGSH, HPSE",2.0515870342214,0.24033215531037,FALSE +"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.5861,1.68,0.0346,101,0.224,"ST3GAL2, ST3GAL1",1.46092390120722,0.649751981665837,TRUE +"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.59275,1.72,0.042,101,0.206,"ST3GAL2, ST3GAL1",1.3767507096021,0.686132779630847,TRUE +"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.7532,2.2,0.00614,652,0.0668,"B3GNT3, ST3GAL4, B4GALT4, B4GALT1",2.21183162885883,1.17522353752445,TRUE +"H2126","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.81012,2.35,0.00156,1328,0.0643,"PIGO, PIGU, PIGA, PIGK, PIGT, GPAA1, PIGS",2.80687540164554,1.19178902707578,TRUE +"H2126","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.29087,0.842,0.65,1256,0.905,"MDH2, PGP",0.187086643357144,0.0433514207947967,FALSE +"H2126","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.25041,0.717,0.83,266,1,"ITPR1, ADCY5, PLA2G12A, PLA2G4A",0.0809219076239261,0,FALSE +"H2126","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.52487,-1.63,0.0696,7343,0.655,"CSNK1D, WNT5A, SUFU, RAB23, GLI2, GLI3",1.15739076038944,0.183758700008217,FALSE +"H2126","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.50948,-1.55,0.0856,8329,0.525,"ITGA2B, ITGA2, ITGA6, CD33, ITGB3, CD7",1.06752623532285,0.279840696594043,FALSE +"H2126","Input","KEGG_HISTIDINE_METABOLISM",0.45345,1.33,0.157,478,0.411,"ALDH3B1, BUD23, ALDH1A3, METTL2B",0.804100347590766,0.386158178123931,FALSE +"H2126","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.22331,0.644,0.92,1620,1,"MUS81, SSBP1, RAD51, BLM",0.0362121726544447,0,FALSE +"H2126","Input","KEGG_HUNTINGTONS_DISEASE",-0.14886,-0.46,0.997,7136,0.998,"NDUFB9, PLCB2, PLCB3, POLR2L, BBC3, COX6B1, POLR2E, HDAC1, POLR2G, ATP5F1B, ATP5F1E, COX7C, ATP5PD, POLR2F, ATP5F1A, DLG4, ATP5PO, GRIN1, COX6A1, TP53, NDUFA4, COX7A2, GPX1, HIP1",0.00130484168834428,0.000869458712628891,FALSE +"H2126","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.40467,-1.21,0.222,7835,0.669,"TPM2, LAMA2, ITGB8, CACNA2D2, ITGA2B, ITGA2, TGFB2, ITGA6, LMNA, ITGA10, ITGB4, ACTG1, SGCB, ITGB3, ACE, CACNA2D1",0.653647025549361,0.174573882232177,FALSE +"H2126","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.21722,0.622,0.945,1643,1,"OCRL, INPP4B, PIKFYVE, PIP4K2C, PI4KB, PIP5K1C, ITPK1, IMPA2, ALDH6A1",0.0245681914907371,0,FALSE +"H2126","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.37326,1.06,0.348,2333,0.625,"FBP1, PRKAB2, MKNK1, FBP2, PRKAB1, PRKAG1, PHKA1, PRKAA1, GYS1, PRKAG2, PYGL, RHEB, IRS2, PTPRF, HK1, PRKAA2, PYGM, RPS6KB2, SREBF1, PPP1R3D, PHKB, IKBKB, ACACB, AKT1, PHKG2, MTOR, MAPK3, PHKA2, GRB2, SHC1, ACACA, ARAF, HK2, PDPK1",0.458420756053419,0.204119982655925,FALSE +"H2126","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.42663,1.23,0.19,978,0.51,"CD40, LTBR",0.721246399047171,0.292429823902064,FALSE +"H2126","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.42385,-1.3,0.157,8043,0.702,"IRF9, IFNAR1, BCL2L1, MYC, IL6ST, CCND1, PIAS2, SPRED1, SPRY4, PIK3R3, SPRY1",0.804100347590766,0.153662887870195,FALSE +"H2126","Input","KEGG_LEISHMANIA_INFECTION",-0.23821,-0.73,0.844,8390,1,"TGFB2, JUN, C3, CYBA",0.073657553374345,0,FALSE +"H2126","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.22884,0.673,0.886,1784,1,"CLDN3, CDH5, CLDN7, ITGB2, RAC2, CTNNA1, PXN, VAV2, VASP, CTNNA2, ROCK1, OCLN, F11R, CTNND1, MAPK13, RAC1",0.0525662781129492,0,FALSE +"H2126","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.52114,-1.58,0.0629,7617,0.519,"ALDH1B1, ALDH9A1",1.20134935455473,0.284832642151542,FALSE +"H2126","Input","KEGG_LONG_TERM_DEPRESSION",0.40839,1.18,0.227,266,0.539,"ITPR1, PLA2G12A, CACNA1A, PLA2G4A",0.643974142806877,0.268411234813261,FALSE +"H2126","Input","KEGG_LONG_TERM_POTENTIATION",-0.24765,-0.766,0.761,7139,1,"PLCB2, PLCB3, CAMK2D, PRKCB, ITPR3, GRIN1, CAMK2B, ADCY8, CAMK2G",0.118615343229427,0,FALSE +"H2126","Input","KEGG_LYSINE_DEGRADATION",-0.39531,-1.2,0.252,6028,0.647,"PLOD3, NSD1, NSD2, TMLHE, ACAT1, SETD1A, EHMT2, SUV39H1, SETDB2, SETDB1, NSD3, SETD2, ALDH1B1, ALDH9A1, GCDH, SETMAR, AASS, PLOD2",0.598599459218456,0.1890957193313,FALSE +"H2126","Input","KEGG_LYSOSOME",-0.28115,-0.887,0.528,7818,0.93,"AP3S1, CTSZ, MFSD8, IGF2R, GLB1, CTSV, PLA2G15, NPC2, CTSF, ARSB, SMPD1, SUMF1, PPT2, AP1S2, MANBA, HEXB, HEXA, CTSS, CTSB, SGSH, CTSK, CTSO",0.277366077466188,0.0315170514460649,FALSE +"H2126","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.23147,-0.712,0.805,7646,1,"DAXX, RPS6KA4, MAPKAPK3, PRKCB, SRF, RRAS2, TGFBR2, CACNA2D2, MYC, FGF13, FGF2, NTRK2, PAK2, MAP2K6, JUND, FLNA, TGFB2, FGFR2, DUSP16, JUN, MECOM, FLNC, TP53, NFATC2, CACNA2D1",0.0942041196321315,0,FALSE +"H2126","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.402,1.18,0.232,1039,0.539,"IAPP, PDX1",0.6345120151091,0.268411234813261,FALSE +"H2126","Input","KEGG_MELANOGENESIS",-0.40343,-1.24,0.196,6863,0.681,"ASIP, CREBBP, GNAS, DCT, PLCB2, PLCB3, CAMK2D, WNT5A, PRKCB, FZD1, GNAI1, TCF7L2, MITF, CAMK2B, ADCY3, ADCY8, FZD7, CAMK2G",0.707743928643524,0.166852888087215,FALSE +"H2126","Input","KEGG_MELANOMA",-0.43512,-1.34,0.176,8000,0.658,"MITF, FGF13, FGF2, CCND1, CDKN2A, TP53, CDK6, PIK3R3",0.75448733218585,0.181774106386044,FALSE +"H2126","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.49098,1.43,0.0986,487,0.344,"ALDH3B1, GSTM3, GSTK1, MGST2, CYP1B1, MGST1, ALDH1A3, GSTZ1",1.00612308505879,0.46344155742847,FALSE +"H2126","Input","KEGG_MISMATCH_REPAIR",0.15748,0.461,0.997,7463,1,"SSBP1, RFC1, MSH3, PCNA, POLD4, MLH3, RFC5, MSH6, RFC3, MSH2, RFC2, RPA1, RPA2, PMS2, RFC4, MLH1, POLD3, RPA3, POLD2, LIG1, POLD1",0.00130484168834428,0,FALSE +"H2126","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.41873,1.21,0.23,2504,0.529,"CAB39L, PRKAA1, CAB39, RHEB, PRKAA2, RPS6KB2, EIF4B, AKT1, MTOR, MAPK3, RICTOR, PDPK1, MLST8",0.638272163982407,0.276544327964814,FALSE +"H2126","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.29637,-0.907,0.504,7327,0.933,"VAV1, PLCG2, TNFRSF10A, PRKCB, IFNAR1, TNFRSF10D, ULBP1, NFAT5, TNFRSF10B, PIK3R3, RAET1L, ULBP2, NFATC2",0.297569463554475,0.0301183562535,FALSE +"H2126","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.40933,1.19,0.238,2607,0.551,"PRSS3, LTB4R2, P2RX4, HRH1, TSPO, P2RY11, TACR1, HCRTR1, MAS1",0.623423042943488,0.258848401148215,FALSE +"H2126","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.16712,-0.517,0.991,7214,1,"TRAF6, CAMK2D, PLCG2, BAD, KIDINS220, RPS6KA4, IRS1, CAMK2B, NTRK2, JUN, TP53, PIK3R3, NGFR, CAMK2G",0.00392634551472468,0,FALSE +"H2126","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.40558,-1.23,0.221,8093,0.676,"PNP, NNT, NT5E, BST1, NMNAT3, NUDT12",0.655607726314889,0.170053304058364,FALSE +"H2126","Input","KEGG_NITROGEN_METABOLISM",-0.48123,-1.51,0.0693,8739,0.551,"CA2, GLS, GLS2, CA12",1.15926676538819,0.258848401148215,FALSE +"H2126","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.20752,0.598,0.947,2371,0.989,"CCL13, TAB3, NFKBIB, BIRC2, IKBKG, XIAP, IKBKB, MAPK13, RELA, MAPK3, CHUK, MAPK12, SUGT1",0.0236500209967266,0.0048037084028206,FALSE +"H2126","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.38277,-1.2,0.209,6694,0.647,"POLL, PRKDC, FEN1, NHEJ1",0.679853713888946,0.1890957193313,FALSE +"H2126","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.26276,-0.812,0.677,8344,0.981,"CCND1, CDKN2A, TP53, CDK6, PIK3R3",0.169411331314856,0.0083309926200515,FALSE +"H2126","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.47003,-1.46,0.105,6681,0.532,"SNW1, NCOR2, NUMBL, RBPJ, CREBBP, JAG1, JAG2, CTBP2, DLL3, MAML1, HDAC1, NOTCH2, DTX3L, MAML2, NOTCH1",0.978810700930062,0.274088367704952,FALSE +"H2126","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.19128,-0.596,0.959,6021,1,"RFC4, ERCC2, ERCC6, POLD3, RPA3, POLE3, POLD2, XPC, GTF2H2, LIG1, POLD1, GTF2H1, POLE, POLE2",0.0181813928293364,0,FALSE +"H2126","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.60494,1.74,0.0262,2635,0.237,"MGAT4A, ST6GAL1, ALG5, ALG8, DPAGT1, ALG9, DPM3, ALG13, ALG3, ALG6, B4GALT1, DOLPP1, DPM1, MAN1B1, MOGS, MAN1A1, STT3B, RPN2, ALG1, MAN2A1, ALG2, ALG14, STT3A, B4GALT3, MGAT1, RFT1, DAD1, DDOST, MAN2A2, ALG11",1.58169870868025,0.625251653989896,TRUE +"H2126","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.46831,-1.45,0.0917,6939,0.519,"CNGB1, CAMK2D, CAMK2B, ADCY3, CAMK2G",1.03763066432998,0.284832642151542,FALSE +"H2126","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.34213,-1.1,0.272,6014,0.714,"MTHFD1, MTHFS, GART, SHMT2, MTHFD1L, ALDH1L1",0.565431095965801,0.146301788223826,FALSE +"H2126","Input","KEGG_OOCYTE_MEIOSIS",0.15329,0.447,1,123,0.999,"ITPR1, ADCY5",0,0.000434511774017692,FALSE +"H2126","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.5262,-1.61,0.0506,6833,0.564,"MAN2B2, GBA, FUCA2, MAN2B1, GLB1, MANBA, HEXB, HEXA",1.2958494831602,0.248720896016658,FALSE +"H2126","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.1508,-0.477,1,7354,1,"ATP6V1H, COX6B1, ATP6V1A, ATP5MG, ATP5F1B, ATP5F1E, COX7C, ATP5PD, ATP5ME, ATP5F1A, ATP5PO, COX6A1, ATP6V1B2, NDUFA4, COX7A2",0,0,FALSE +"H2126","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.67285,1.93,0.0128,106,0.155,"GCNT3, GALNT6, ST3GAL2, ST3GAL1, GALNT3",1.89279003035213,0.809668301829709,TRUE +"H2126","Input","KEGG_P53_SIGNALING_PATHWAY",-0.33435,-1.04,0.351,8005,0.757,"COP1, ATR, CCND1, TNFRSF10B, CDKN2A, TP53, CDK6, THBS1, STEAP3, SERPINE1",0.454692883534176,0.120904120499927,FALSE +"H2126","Input","KEGG_PANCREATIC_CANCER",-0.22021,-0.706,0.856,8046,0.999,"TGFBR2, BCL2L1, CCND1, TGFB2, CDKN2A, TP53, CDK6, PIK3R3",0.0675262353228468,0.000434511774017692,FALSE +"H2126","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.45499,1.32,0.139,536,0.412,"ENPP1, PPCDC, PPCS",0.856985199745905,0.385102783966865,FALSE +"H2126","Input","KEGG_PARKINSONS_DISEASE",0.24269,0.705,0.824,2827,1,"CASP9, NDUFA2, UQCRH, SLC25A5, CYC1, VDAC2, UBA7, UBE2L3, UQCR10, SNCA, UBE2J1, NDUFB1, NDUFAB1, SLC18A1, NDUFA9, UQCRQ, SLC25A31, NDUFC2, ATP5MC2, NDUFB7, SLC25A6, CYCS, PPID, UBE2G2, PARK7, NDUFV2, NDUFS6, UCHL1, UBE2G1, UQCRB, NDUFA5, NDUFB6, NDUFA7, NDUFC1, CASP3, NDUFS4",0.0840727883028842,0,FALSE +"H2126","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.23423,-0.715,0.824,8023,1,"TUBB4A, ARHGEF2, ARPC1A, HCLS1, WAS, ACTG1",0.0840727883028842,0,FALSE +"H2126","Input","KEGG_PATHWAYS_IN_CANCER",-0.29321,-0.893,0.568,7429,0.932,"HDAC1, PLCG2, BAD, APPL1, WNT5A, ITGA3, SUFU, SMAD3, LAMB3, PRKCB, LAMC2, FZD1, LAMA2, DAPK1, COL4A2, TPR, TCF7L2, LAMB2, MITF, LAMC1, TGFBR2, MMP1, FOXO1, BCL2L1, MYC, FGF13, FGF2, ITGA2B, CCND1, FN1, ITGA2, FH, TGFB2, FGFR2, ITGA6, JUN, GLI2, GLI3, PIAS2, FZD7, MECOM, CDKN2A, GSTP1, TP53, CDK6, PIK3R3, PML, COL4A1",0.245651664288981,0.0305840876460186,FALSE +"H2126","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.46733,1.37,0.118,1831,0.369,"UGDH, AKR1B1, DCXR",0.928117992693875,0.43297363384094,FALSE +"H2126","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.62853,1.79,0.0192,1343,0.229,"FBP1, ALDOB, G6PD, FBP2, PRPS1, PRPS1L1, PRPS2, PGM2, RBKS, PGM1",1.71669877129645,0.640164517660112,TRUE +"H2126","Input","KEGG_PEROXISOME",0.47747,1.39,0.125,1757,0.384,"GSTK1, ACOX3, ABCD1, PXMP4, SCP2, PRDX1, ACSL1, ACAA1, ACSL3, IDH2, ECH1, SLC27A2, PEX1, SLC25A17, MPV17, PEX26, PMVK, PEX13, MVK, CAT, CRAT, IDH1, PEX16, AMACR, ACSL5, ACSL6, XDH",0.903089986991944,0.415668775632469,FALSE +"H2126","Input","KEGG_PHENYLALANINE_METABOLISM",0.39329,1.13,0.291,1031,0.573,"ALDH3B1, ALDH1A3, MIF",0.536107011014093,0.24184537803261,FALSE +"H2126","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25005,0.72,0.829,1584,1,"ITPR1, OCRL, CDS1, INPP4B, PIKFYVE, PIP4K2C, PI4KB, PIP5K1C, DGKE, ITPK1, IMPA2",0.0814454694497265,0,FALSE +"H2126","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.27965,-0.855,0.607,7910,0.96,"ALAS1, FECH, FTH1",0.216811308924742,0.0177287669604316,FALSE +"H2126","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.44366,1.28,0.172,872,0.443,"FABP6, FABP3, ACADM, ACOX3, OLR1, SCP2, GK2, ACSL1, ACAA1, ACSL3, SLC27A2, FABP5",0.764471553092451,0.35359627377693,FALSE +"H2126","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.37483,-1.11,0.283,7144,0.71,"RFXAP, RFXANK, RFX5, BTK, TAP1, PTPRC, CD79A",0.54821356447571,0.148741651280925,FALSE +"H2126","Input","KEGG_PRION_DISEASES",-0.32574,-1.01,0.394,8022,0.788,"LAMC1, NOTCH1, CCL5",0.404503778174426,0.103473782510445,FALSE +"H2126","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.19384,0.568,0.973,2436,0.995,"ADCY5, FZR1, PKMYT1, ANAPC11, CDC25B, CDC26, MAPK13, AKT1, MAPK3, CDC23, ANAPC4, GNAI3, ARAF, MAPK12, CDC16, ANAPC5",0.0118871597316481,0.00217691925427455,FALSE +"H2126","Input","KEGG_PROPANOATE_METABOLISM",-0.23567,-0.725,0.818,8092,1,"LDHB, ALDH9A1, ACSS3, ACSS1",0.087246696328677,0,FALSE +"H2126","Input","KEGG_PROSTATE_CANCER",-0.24166,-0.747,0.795,7987,1,"TCF7L2, FOXO1, CCND1, FGFR2, GSTP1, TP53, PIK3R3",0.0996328713435297,0,FALSE +"H2126","Input","KEGG_PROTEASOME",-0.17793,-0.562,0.979,2238,1,"PSMA5, PSMF1, PSMB7, POMP, PSMB6, PSMB2, PSMD12, PSMA1, PSMD2, PSMC6, PSMA6, PSMA3, PSMB1, PSMA7, PSMC3, PSMB5, PSMA2, PSMA8, PSMB10, PSMB4, PSMC4, PSMD3, PSMC1, PSME2, PSMD13, PSMD11, PSME1, PSMA4, PSMD4, PSMC2, PSMC5, PSMD6, PSMD1, PSME3, PSMD8, PSMD7, PSMB8, SEM1, PSMD14, PSMB3, PSMB9",0.00921730819686218,0,FALSE +"H2126","Input","KEGG_PROTEIN_EXPORT",0.66921,1.93,0.0155,2359,0.155,"SRPRB, SRPRA, SEC62, SRP19, SRP54, SEC11C, SRP68, SRP72, SPCS2, SEC61B, SEC61A1, SPCS3, OXA1L",1.80966830182971,0.809668301829709,TRUE +"H2126","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.66755,-2,0.00576,8416,0.428,"PCK2, CA2, GLS, GLS2",2.23957751657679,0.368556230986828,FALSE +"H2126","Input","KEGG_PURINE_METABOLISM",0.33619,0.992,0.419,1077,0.724,"PDE4D, ADCY5, PAPSS2, CANT1, FHIT, ENPP1, NME3, RRM2, PRPS1, PRPS1L1, NT5C2, PDE5A, NME1, ADA, NUDT5, GDA, PRPS2, AK1",0.377785977033705,0.140261433802853,FALSE +"H2126","Input","KEGG_PYRIMIDINE_METABOLISM",0.22053,0.641,0.921,1150,1,"CANT1, CMPK1, CDA, NME3, RRM2, TYMP, TXNRD2, NT5C2, NME1, TXNRD1, CTPS1",0.0357403698031511,0,FALSE +"H2126","Input","KEGG_PYRUVATE_METABOLISM",-0.29274,-0.901,0.532,8021,0.929,"PKM, LDHB, ME3, ALDH9A1, PCK2, ACSS1",0.274088367704952,0.0319842860063582,FALSE +"H2126","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.23371,-0.707,0.861,7257,1,"IQGAP2, ABI2, VAV1, ARHGEF7, PAK3, MOS, MSN, ITGA3, CFL2, ENAH, FGD1, RRAS2, ITGB8, FGF13, FGF2, ARPC1A, PAK2, ITGA2B, SCIN, FN1, ITGA2, WAS, FGFR2, ITGA6, ACTN1, ITGA10, ITGB4, WASF1, PIK3R3, ACTG1, MYLK, ITGB3",0.0649968485463452,0,FALSE +"H2126","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.39457,1.15,0.271,1098,0.565,"PRKAA1, PRKAA2, ATG4C",0.567030709125594,0.247951552180562,FALSE +"H2126","Input","KEGG_RENAL_CELL_CARCINOMA",-0.26041,-0.789,0.712,8261,1,"PAK2, FH, TGFB2, JUN, FLCN, PIK3R3",0.147520006363144,0,FALSE +"H2126","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.61812,-1.89,0.0197,7585,0.515,"LNPEP, ANPEP, ACE",1.70553377383841,0.288192770958809,FALSE +"H2126","Input","KEGG_RETINOL_METABOLISM",-0.40012,-1.25,0.181,7759,0.687,"ADH4, ADH7, ADH1C, DHRS9, ALDH1A2, CYP3A7",0.742321425130815,0.16304326294045,FALSE +"H2126","Input","KEGG_RIBOFLAVIN_METABOLISM",0.57825,1.66,0.0398,876,0.226,"PHPT1, ENPP1, RFK, ACP6",1.40011692792631,0.645891560852599,TRUE +"H2126","Input","KEGG_RIBOSOME",0.37424,1.09,0.313,3841,0.607,"RPL37, RPL35, RPL7A, RPL14, RPL18, RPS29, RPL38, RPL29, RPL18A, RPL22, RPL13A, RPS9, RPL36, RPL34, RPL7, RPL10A, RPS5, RPS16, RPL26, RPL23A, RPLP2, RPL30, RPS11, RPL37A, RPS15, RPS18, RPS3, RPL10, RPL15, RPS27A, RPL3, RPL28, RPL6, RPL17, RPL27, RPL35A, RPS13, RPS2, RPS12, UBA52, RPL9, RPS27L, RPS3A, RPS10, RPL19, RPS4X, RPS15A, RPS24, RPS8, RPS17, FAU, RPS25",0.504455662453552,0.216811308924742,FALSE +"H2126","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.16254,-0.516,0.995,7873,1,"DDX58, AZI2, CYLD, ISG15",0.00217691925427455,0,FALSE +"H2126","Input","KEGG_RNA_DEGRADATION",-0.30221,-0.936,0.494,5684,0.895,"TENT4A, PARN, C1D, LSM3, LSM7, EXOSC1, EXOSC7, EXOSC5, EXOSC8, EXOSC4, EXOSC3, HSPD1, PNPT1, LSM8, DCPS, LSM2, EXOSC2, DCP2, LSM6, MPHOSPH6, ENO2, DCP1B",0.306273051076353,0.048176964684088,FALSE +"H2126","Input","KEGG_RNA_POLYMERASE",-0.24479,-0.752,0.783,2161,1,"POLR3K, POLR3B, POLR3C, POLR3F, POLR2I, POLR3GL, POLR3A, POLR3H, POLR3D, POLR2C, POLR2B, POLR1C, POLR1D, POLR1A, POLR1B, POLR2H, POLR2J, POLR3G, POLR1E, POLR2K, POLR2D, POLR2A, POLR2L, POLR2E, POLR2G, POLR2F",0.106238237942057,0,FALSE +"H2126","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.4481,1.28,0.189,478,0.443,"PAPSS2, BUD23, CTH, METTL2B",0.723538195826756,0.35359627377693,FALSE +"H2126","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.3302,-1,0.414,7663,0.793,"LAMB3, LAMC2, LAMA2, COL4A2, LAMB2, LAMC1, BCL2L1, MYC, ITGA2B, CCND1, FN1, ITGA2, ITGA6, PIAS2, TP53, CDK6, PIK3R3, COL4A1",0.382999658879101,0.100726812682396,FALSE +"H2126","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.36545,1.07,0.337,2249,0.632,"STX16, SEC22B, YKT6, VAMP7, BNIP1, BET1L, STX18, SNAP47, VAMP3, VTI1B, SNAP23, GOSR1, SNAP29",0.472370099128661,0.199282921717615,FALSE +"H2126","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.3853,-1.21,0.213,8038,0.669,"GLB1, KDSR, SMPD1, PLPP1, UGT8",0.671620396561262,0.174573882232177,FALSE +"H2126","Input","KEGG_SPLICEOSOME",-0.36522,-1.12,0.288,5534,0.709,"RBM8A, SF3B5, SNRPD1, SNRPD2, HNRNPU, ACIN1, SNRPG, PQBP1, SRSF5, SRSF6, PRPF18, LSM3, LSM7, SRSF10, WBP11, PPIL1, RBMX, HNRNPC, SNRPC, SF3B6, SRSF1, MAGOHB, ALYREF, SRSF7, TCERG1, SNRNP27, PRPF31, RBM25, SF3B3, ISY1, SF3A3, U2AF2, SRSF3, ZMAT2, CTNNBL1, SNRPB, DDX39B, SRSF2, EFTUD2, SNRPF, BUD31, SRSF8, CWC15, LSM8, SNW1, PLRG1, PRPF38A, DDX42, LSM2, SMNDC1, HNRNPA1, SYF2, TRA2B, SNU13, BCAS2, RBM17, EIF4A3, PRPF40A, RBM22, SLU7, SNRNP40, CDC5L, SRSF4, HNRNPA3, U2SURP, CDC40, HNRNPM, LSM6, PRPF19, TRA2A, HNRNPK, TXNL4A",0.540607512240769,0.149353764816933,FALSE +"H2126","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.60943,1.75,0.0237,1343,0.248,"ENPP1, GYS1, PYGL, UGDH, UXS1, HK1, PYGM, PGM2, PGM2L1, PGM1",1.6252516539899,0.605548319173784,TRUE +"H2126","Input","KEGG_STEROID_BIOSYNTHESIS",0.62732,1.8,0.0226,831,0.247,"MSMO1, DHCR24, SC5D, NSDHL, FDFT1, DHCR7",1.6458915608526,0.607303046740334,TRUE +"H2126","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.55637,1.59,0.059,521,0.266,"SULT2B1, SRD5A3, CYP1B1, COMT, CYP21A2",1.22914798835786,0.575118363368933,FALSE +"H2126","Input","KEGG_SULFUR_METABOLISM",0.78472,2.27,0,216,0.0628,"SULT2B1, SULT1A3, PAPSS2",Inf,1.2020403562628,TRUE +"H2126","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.49155,-1.49,0.105,7521,0.549,"SSB, TRIM21, C1S, ACTN1, C3, C1R",0.978810700930062,0.260427655549908,FALSE +"H2126","Input","KEGG_TASTE_TRANSDUCTION",0.32059,0.93,0.507,209,0.799,"CACNA1A",0.294992040666664,0.0974532206860086,FALSE +"H2126","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.59573,1.73,0.0322,1468,0.228,"IDI1, PDSS2, FDPS, MVD, PMVK, MVK, HMGCR",1.49214412830417,0.642065152999546,TRUE +"H2126","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.2805,-0.841,0.594,6878,0.977,"CREBBP, SMAD4, SMAD1, RBL1, BMPR2, SMAD3, ACVR2A, TGFBR2, MYC, TGFB2, INHBA, FST, THBS1, THBS2",0.226213555018806,0.0101054362812269,FALSE +"H2126","Input","KEGG_THYROID_CANCER",-0.35137,-1.05,0.364,7959,0.77,"TPR, TCF7L2, MYC, CCND1, TP53",0.438898616350944,0.113509274827518,FALSE +"H2126","Input","KEGG_TIGHT_JUNCTION",0.26989,0.789,0.705,1863,0.971,"CLDN3, MYH3, CLDN7, EPB41L3, EPB41L1, TJP3, RAB13, CGN, CTNNA1, LLGL2, PRKCD, AMOTL1, CTNNA2, VAPA, OCLN, F11R, PATJ, EXOC4, AKT1, CTTN",0.151810883008601,0.0127807700919951,FALSE +"H2126","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.18618,-0.579,0.971,7601,1,"TOLLIP, TLR3, SPP1, IFNAR1, MAP2K6, JUN, CCL5, PIK3R3, CTSK",0.0127807700919951,0,FALSE +"H2126","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.44076,-1.34,0.152,7325,0.658,"CYP1A1, WARS2, ALDH1B1, ALDH9A1, GCDH, KYNU, MAOB",0.818156412055227,0.181774106386044,FALSE +"H2126","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.26787,0.774,0.769,1039,0.986,"CACNA1A, IRS2, PRKCD, HK1, PDX1",0.114073660198569,0.0061230850587888,FALSE +"H2126","Input","KEGG_TYROSINE_METABOLISM",0.53264,1.54,0.0843,487,0.304,"HGD, ALDH3B1, COMT, BUD23, ALDH1A3, METTL2B, GSTZ1",1.07417242537526,0.517126416391246,FALSE +"H2126","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.17534,-0.539,0.994,8256,1,"PTPRC, PAK2, NFAT5, JUN, PIK3R3, NFATC2",0.00261361560268669,0,FALSE +"H2126","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.23048,0.666,0.903,3037,1,"FZR1, ANAPC11, SYVN1, MID1, UBE2Q1, BIRC2, PIAS3, HERC1, UBE4A, SMURF1, UBE2M, UBA7, RNF7, UBE2L3, XIAP, RCHY1, BRCA1, PPIL2, UBE2NL, CUL4A, CDC26, CUL4B, UBE2J1, UBE3C, MGRN1, UBE2N, NEDD4, CDC23, ANAPC4, CUL2, UBE2G2, UBE2A, CDC16, STUB1, ANAPC5, HERC4, ELOC, ITCH, UBE2G1, UBE2F, BIRC6, CUL1, TRIP12, TRIM37, ELOB, CBL, CUL7, UBE2Z, CUL3, HERC2, UBE2C, UBE2D2",0.0443122496864942,0,FALSE +"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.34285,-1.06,0.301,6260,0.765,"PDHA1, PDHB, LARS2, BCAT1",0.521433504406157,0.116338564846382,FALSE +"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.34823,-1.04,0.346,7932,0.757,"ACADSB, ALDH9A1, ACAA2, HMGCS2, BCAT1, OXCT1, IVD",0.460923901207223,0.120904120499927,FALSE +"H2126","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.33844,0.98,0.445,1500,0.735,"ITPR1, ADCY5, PLA2G12A, PLA2G4A, CACNA1F, PRKCD, MYL6, GNA11, ROCK1",0.351639989019068,0.133712660915805,FALSE +"H2126","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.20693,0.608,0.941,2718,0.993,"AQP3, ARHGDIB, RAB11A, NSF, RAB11B, DCTN5, DYNC1LI2, DYNC1H1, RAB5B",0.0264103765727431,0.00305075150461883,FALSE +"H2126","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.23268,0.677,0.897,2337,1,"PLA2G12A, CASP9, PLA2G4A, RAC2, PXN, RAC3, CHP1, MAPK13, RAC1, AKT1, MAPK3, HSPB1, SPHK2, MAPK12",0.0472075569559079,0,FALSE +"H2126","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.24131,0.699,0.854,1995,1,"KDELR3, TCIRG1, PDIA4, ERO1A, KDELR1, SEC61B, ATP6V0A1, ATP6V0D1, ATP6V1B1, ATP6V0C",0.068542129310995,0,FALSE +"H2126","Input","KEGG_VIRAL_MYOCARDITIS",0.38191,1.11,0.287,528,0.596,"MYH3, CASP9, CD40, ITGB2, RAC2, BID",0.542118103266008,0.224753740259764,FALSE +"H2126","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.30079,-0.941,0.465,6878,0.902,"CREBBP, SMAD4, CACYBP, SIAH1, CTBP2, PLCB2, PLCB3, CAMK2D, WNT5A, TBL1X, TBL1XR1, LRP6, SMAD3, PRKCB, FZD1, TCF7L2, CAMK2B, MYC, FOSL1, NFAT5, CCND1, JUN, FZD7, TP53, NFATC2, CAMK2G",0.332547047110046,0.0447934624580583,FALSE +"H3255","Input","KEGG_ABC_TRANSPORTERS",-0.34284,-1.05,0.344,9404,0.805,"ABCA1, ABCB4, ABCD1, ABCG2",0.46344155742847,0.0942041196321315,FALSE +"H3255","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.22699,0.695,0.876,2513,0.937,"CEBPA, CCND1, RUNX1, BAD, TCF7L1, STAT3, RARA, IKBKG, HRAS, AKT1, TCF7L2, PIK3R3, IKBKB",0.0574958938319193,0.0282604091122217,FALSE +"H3255","Input","KEGG_ADHERENS_JUNCTION",0.2297,0.714,0.813,957,0.936,"EGFR, LMO7, FGFR1, NECTIN4, EP300, AFDN, ERBB2, CTNNB1",0.0899094544059319,0.0287241512618947,FALSE +"H3255","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.18008,-0.539,0.992,7785,1,"JAK2, CPT1C, PTPN11, ACACB, TRAF2, CAMKK2, SLC2A1, MAPK8, MAPK10, PRKCQ, IRS2",0.00348832784582135,0,FALSE +"H3255","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.32832,-0.987,0.42,9035,0.824,"ABAT, NIT2, GFPT2, GLUD2",0.3767507096021,0.0840727883028842,FALSE +"H3255","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.31997,-0.965,0.461,8484,0.845,"PIK3CB, SFN, ATP1B3, IRS2",0.336299074610352,0.0731432910503077,FALSE +"H3255","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.45433,1.36,0.125,71,0.649,"FADS2, PLA2G4A",0.903089986991944,0.187755303199631,FALSE +"H3255","Input","KEGG_ALZHEIMERS_DISEASE",-0.15801,-0.477,0.998,6846,1,"GSK3B, NDUFA9, CASP3, PLCB3, ATP5F1A, NDUFS2, NDUFB7, UQCR10, UQCRQ, MAPK3, CASP9, CHP1, ATP5F1C, GNAQ, GRIN1, NAE1, PLCB2, ATF6, ATP5F1E, CAPN1, ATP5PB, CASP7, PPP3CC, CYC1, PLCB4, NDUFA2, MAPT, LPL, IDE, LRP1, PSEN2, FADD, CACNA1F, SNCA",0.000869458712628891,0,FALSE +"H3255","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.47743,-1.46,0.102,8698,0.67,"LARS2, DARS2, WARS2, SEPSECS, CARS2",0.991399828238082,0.173925197299174,FALSE +"H3255","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.29991,-0.894,0.561,8555,0.861,"GNPDA1, GPI, FPGT, PGM2, GNE, UAP1, GFPT2, PGM1, GALK2",0.251037138743839,0.0649968485463452,FALSE +"H3255","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.40337,-1.19,0.238,9454,0.736,"MAP2K6, NEFL, PRPH, PRPH2, NEFH, TP53",0.623423042943488,0.133122185662501,FALSE +"H3255","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.25406,-0.748,0.742,8500,0.906,"RFX5, CTSL, HSP90AB1, RFXAP, HSPA2, NFYA, CD74",0.129596094720973,0.0428718023231869,FALSE +"H3255","Input","KEGG_APOPTOSIS",-0.29435,-0.876,0.594,7123,0.806,"BAX, EXOG, CASP9, RELA, CHP1, CHUK, TNFRSF10C, DFFB, IRAK1, XIAP, CAPN1, DFFA, TRAF2, IRAK3, CASP7, PIK3CB, PPP3CC, ATM, IRAK2, IRAK4, BIRC2, TNFRSF10B, TNFRSF10D, FADD, TP53",0.226213555018806,0.0936649581949093,FALSE +"H3255","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.40376,1.25,0.194,279,0.536,"GGT5, PTGS2, PLA2G4A, GGT1",0.712198270069774,0.27083521030723,FALSE +"H3255","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.40906,1.26,0.171,1416,0.541,"ARG2, PRODH, PRODH2, ODC1, ALDH2, PYCR1, GLUL, GAMT, ALDH3A2, GLS, GLS2, OAT, MAOA, PYCR2, CKB, ALDH4A1",0.767003889607846,0.266802734893431,FALSE +"H3255","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.58775,-1.75,0.0362,8939,0.688,"SLC8A1, CACNA2D1, ITGB3, LEF1, ITGB1, CDH2, CACNA1F, ITGA5, ITGB8, ITGA6, DES, DSC2, DSG2",1.44129142946683,0.162411561764489,FALSE +"H3255","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.3471,1.07,0.329,1816,0.67,"ALDH2, ALDH3A2, UGDH",0.482804102050026,0.173925197299174,FALSE +"H3255","Input","KEGG_AXON_GUIDANCE",-0.28258,-0.846,0.62,8086,0.837,"PAK2, SRGAP2, SRGAP3, PAK3, SEMA5A, FYN, EPHB6, SRGAP1, NCK1, EFNA5, GNAI2, PPP3CC, RAC2, EFNB2, NCK2, CXCR4, RASA1, NFATC1, ABLIM3, SEMA7A, ITGB1, NFAT5, L1CAM, SEMA3F, EFNB1, ROBO1",0.207608310501746,0.07727454200674,FALSE +"H3255","Input","KEGG_BASAL_CELL_CARCINOMA",-0.62416,-1.89,0.00938,9283,1,"LEF1, FZD7, WNT10A, WNT7A, GLI2, TP53",2.02779716162094,0,FALSE +"H3255","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.12719,-0.396,1,7915,1,"TBPL1, GTF2F2, GTF2F1, GTF2B",0,0,FALSE +"H3255","Input","KEGG_BASE_EXCISION_REPAIR",0.24011,0.746,0.794,2064,0.938,"LIG3, POLE2, POLE4, XRCC1, POLE, POLE3, POLB, POLD4",0.100179497572904,0.0277971616209356,FALSE +"H3255","Input","KEGG_BETA_ALANINE_METABOLISM",-0.29132,-0.903,0.574,8443,0.853,"SRM, ABAT, ALDH1B1, ALDH7A1",0.241088107602027,0.069050968832477,FALSE +"H3255","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.42747,1.3,0.16,1479,0.565,"FADS2, ACAA1, ACOT2, PECR, HSD17B12, SCD5, ACOX1",0.795880017344075,0.247951552180562,FALSE +"H3255","Input","KEGG_BLADDER_CANCER",-0.29424,-0.889,0.562,8246,0.823,"TYMP, RASSF1, MMP1, MAP2K1, RAF1, ARAF, CDKN2A, TP53",0.250263684430939,0.0846001647877302,FALSE +"H3255","Input","KEGG_BUTANOATE_METABOLISM",0.3346,1.02,0.376,1824,0.742,"OXCT1, ALDH2, HMGCS1, ALDH3A2, ALDH5A1, ACAT2, BDH2, EHHADH",0.424812155072339,0.129596094720973,FALSE +"H3255","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.4408,-1.36,0.117,8461,0.741,"SOS1, PIK3CB, PPP3CC, RAC2, BCL10, INPP5D, MAP2K1, RAF1, NFATC1, CARD11, MALT1, BLNK, NFAT5, CD79A, PLCG2, CD79B",0.931814138253838,0.130181792020672,FALSE +"H3255","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.23461,-0.696,0.836,8456,0.944,"F2R, CD38, PPP3CC, PHKA1, PLCB4, ATP2B2, ATP2B4, PHKB, SLC8A1, BST1, PHKG2, TRPC1, MYLK, PDE1C, CACNA1F, PLCD3, PLCG2",0.0777937225609836,0.025028005701931,FALSE +"H3255","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.32017,-0.962,0.463,8541,0.823,"CYC1, ATP1B3, SLC8A1, CACNA2D1, CACNA1F, TPM2",0.334419008982047,0.0846001647877302,FALSE +"H3255","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.30421,0.953,0.476,1197,0.783,"ICAM1, SDC2, CLDN3, VCAN, CADM1, SDC1, CDH15, CDH3, OCLN, CLDN4, SDC3",0.322393047279507,0.106238237942057,FALSE +"H3255","Input","KEGG_CELL_CYCLE",-0.25617,-0.768,0.77,8299,0.878,"ESPL1, CDK2, YWHAQ, CDC26, PLK1, ATM, CHEK1, SMC1B, SFN, CDK1, CDKN2C, YWHAZ, TFDP1, TFDP2, TGFB2, CDKN2A, ORC3, TP53",0.113509274827518,0.0565054840938974,FALSE +"H3255","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.29396,-0.891,0.566,8412,0.855,"GNAI2, CXCL5, SOS1, PIK3CB, GRK6, RAC2, BCAR1, CCR4, CXCR4, PLCB4, SHC4, MAP2K1, CSK, RAF1, ELMO1, DOCK2, WAS, CCR10, CCR9, RASGRP2",0.247183568811729,0.0680338852718274,FALSE +"H3255","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.29429,-0.889,0.55,7990,0.823,"PTPN11, SHC1, CBLB, SOS1, PIK3CB, STAT5A, SHC4, MAP2K1, RAF1, ARAF, TGFB2, CDKN2A, CBL, TP53",0.259637310505756,0.0846001647877302,FALSE +"H3255","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.26201,0.8,0.7,2625,0.924,"CRY1, CLOCK, PER1, ARNTL",0.154901959985743,0.0343280287798933,FALSE +"H3255","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.40662,1.29,0.147,2829,0.556,"DLST, ACO1, MDH2, SDHA, OGDHL, OGDH, IDH2, IDH1, SUCLG2, PCK2, DLD, SUCLG1",0.832682665251824,0.254925208417942,FALSE +"H3255","Input","KEGG_COLORECTAL_CANCER",-0.42461,-1.27,0.184,8484,0.672,"PIK3CB, RAC2, APPL1, MAP2K1, RAF1, ARAF, MAPK8, LEF1, MAPK10, TGFB2, TP53, BIRC5",0.735182176990464,0.172630726946175,FALSE +"H3255","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.31916,0.986,0.417,1039,0.745,"PLAT, THBD, TFPI, PLAUR, CD55, C4A, F9, CFI, F8",0.379863945026242,0.127843727251707,FALSE +"H3255","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.35588,-1.08,0.32,6843,0.828,"ADI1, MAT1A, MAT2B, TAT, APIP, GOT2, MAT2A, AHCY, AHCYL1, SDS, SRM, MTAP",0.494850021680094,0.0819696632151199,FALSE +"H3255","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.27157,0.826,0.67,1302,0.9,"LIFR, EGFR, OSMR, CSF1, TGFB1, CCL28, TNFRSF21, IL1R1, IFNGR1, IL25, VEGFA, LTBR, TNFRSF19, TNFRSF1A, IL1RAP",0.173925197299174,0.0457574905606751,FALSE +"H3255","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.42134,-1.29,0.172,8691,0.705,"POLR3A, POLR3B, IL6, TBK1, ZBP1, IL18, PYCARD, TREX1",0.764471553092451,0.151810883008601,FALSE +"H3255","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.47347,-1.46,0.0977,8939,0.67,"SLC8A1, CACNA2D1, ITGB3, ITGB1, TGFB2, CACNA1F, ITGA5, TPM2, ITGB8, ITGA6, DES",1.01010543628123,0.173925197299174,FALSE +"H3255","Input","KEGG_DNA_REPLICATION",0.39988,1.21,0.205,3839,0.528,"SSBP1, POLE2, POLE4, RPA3, POLE, POLE3, POLD4, RFC3, LIG1, MCM4, MCM3, RFC1, MCM6, POLA2, PCNA, MCM7, PRIM1",0.688246138944246,0.277366077466188,FALSE +"H3255","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.34053,-1.03,0.383,8461,0.802,"SOS1, NOTCH2, MAP2K1, ETS1, NOTCH1",0.416801226031377,0.0958256317158365,FALSE +"H3255","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.48669,-1.48,0.0912,8919,0.724,"ALDH3B1, GSTM3, GSTM2, ALDH1A3, GSTM1, GSTO1, ALDH3A1, GSTM4, GSTP1",1.04000516167158,0.140261433802853,FALSE +"H3255","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.3388,-1.01,0.408,7770,0.816,"UMPS, CES1, CES2, TYMP, GMPS, HPRT1, IMPDH2, UCK2, CDA",0.38933983691012,0.0883098412461389,FALSE +"H3255","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.43397,-1.29,0.177,8767,0.705,"COL5A2, COL6A2, HSPG2, COL3A1, ITGB3, COL6A1, VTN, COL5A1, ITGB1, LAMA3, LAMA4, ITGA5, COL4A1, ITGB8, COL1A2, COL4A6, ITGA6, COL4A2",0.752026733638193,0.151810883008601,FALSE +"H3255","Input","KEGG_ENDOCYTOSIS",-0.26473,-0.808,0.685,7952,0.822,"STAM, DNM2, RAB11A, PIP4K2B, CHMP2A, PSD, EHD2, CBLB, WWP1, VTA1, F2R, EHD1, PDCD6IP, GRK6, IGF1R, SH3GLB1, EHD3, ASAP1, CHMP2B, CXCR4, DNM1L, EHD4, ARAP2, VPS4B, SH3GLB2, SNF8, GIT2, ASAP2, HSPA2, VPS36, RAB11FIP2, PIP5K1A, ACAP2, CBL, DNM1, DAB2",0.164309428507574,0.0851281824599496,FALSE +"H3255","Input","KEGG_ENDOMETRIAL_CANCER",-0.27938,-0.843,0.632,8461,0.813,"SOS1, PIK3CB, ILK, MAP2K1, RAF1, ELK1, ARAF, LEF1, TP53",0.199282921717615,0.0899094544059319,FALSE +"H3255","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.19706,-0.598,0.953,8738,1,"HBEGF, CSK, MAPK8, MAP2K4, MAPK10, PLCG2",0.0209070993616736,0,FALSE +"H3255","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.29974,-0.925,0.504,8052,0.855,"SHC1, PAK2, PAK3, ABL2, CBLB, NCK1, SOS1, PIK3CB, NCK2, HBEGF, MAP2K7, STAT5A, SHC4, MAP2K1, RAF1, ELK1, ARAF, MAPK8, MAP2K4, MAPK10, CBL, PLCG2",0.297569463554475,0.0680338852718274,FALSE +"H3255","Input","KEGG_ETHER_LIPID_METABOLISM",0.39645,1.18,0.239,1097,0.529,"PLA2G4A, LPCAT2, PLPP1, PLA2G12A, PLPP2, PLD1, PAFAH2",0.621602099051862,0.276544327964814,FALSE +"H3255","Input","KEGG_FATTY_ACID_METABOLISM",0.35348,1.09,0.307,2499,0.647,"ALDH2, ACSL5, ECI2, ACAA1, GCDH, ALDH3A2, ACAT2, ACOX1, ACSL1, ACADSB, EHHADH, ACSL4, ACADVL, ECHS1, ACOX3",0.512861624522813,0.1890957193313,FALSE +"H3255","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.33913,-1.02,0.384,8221,0.808,"FYN, PLA2G2D, SOS1, PIK3CB, LAT, RAC2, MAP2K7, INPP5D, MAP2K1, RAF1, MAPK8, MAP2K4, MAPK10, MAP2K6, PLCG2, PLA2G6",0.415668775632469,0.0925886392254138,FALSE +"H3255","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.30258,-0.921,0.517,8331,0.851,"VASP, PIK3CB, LAT, RAC2, ASAP1, DNM1L, INPP5D, MAP2K1, RAF1, DOCK2, WAS, ASAP2, PIP5K1A, DNM1, PLCG2, PLA2G6",0.286509456906058,0.0700704399154121,FALSE +"H3255","Input","KEGG_FOCAL_ADHESION",-0.41381,-1.26,0.176,7690,0.67,"RAC3, RAP1B, LAMB4, ZYX, FLNB, ITGA3, RAPGEF1, XIAP, SHC1, PAK2, COL6A3, PAK3, FYN, COL1A1, VASP, HGF, SOS1, PIK3CB, FLNA, ILK, IGF1R, RAC2, DIAPH1, VCL, BCAR1, COL5A2, DOCK1, COL6A2, SHC4, MAP2K1, RAF1, ELK1, COL3A1, BIRC2, ITGB3, MAPK8, COL6A1, VTN, MYLK, COL5A1, FLNC, MAPK10, ITGB1, LAMA3, LAMA4, CAV1, ITGA5, COL4A1, ITGB8, PARVB, COL1A2, COL4A6, ITGA6, CAV2, COL4A2",0.75448733218585,0.173925197299174,FALSE +"H3255","Input","KEGG_FOLATE_BIOSYNTHESIS",0.39984,1.24,0.194,2958,0.514,"GGH, ALPI, ALPP, ALPG, DHFR",0.712198270069774,0.289036881004724,FALSE +"H3255","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.2781,0.853,0.609,173,0.889,"FBP1, FBP2",0.215382707367125,0.0510982390297863,FALSE +"H3255","Input","KEGG_GALACTOSE_METABOLISM",-0.35333,-1.07,0.326,8632,0.814,"PGM2, PGM1, GALK2, PFKP",0.486782399932061,0.0893755951107988,FALSE +"H3255","Input","KEGG_GAP_JUNCTION",0.19907,0.605,0.952,1186,0.968,"EGFR, GUCY1A1, GJA1, PLCB1, ITPR1, MAPK7, ITPR3",0.0213630516155257,0.0141246426916063,FALSE +"H3255","Input","KEGG_GLIOMA",-0.38066,-1.18,0.23,8461,0.736,"SOS1, PIK3CB, IGF1R, SHC4, MAP2K1, RAF1, ARAF, CDKN2A, PLCG2, TP53",0.638272163982407,0.133122185662501,FALSE +"H3255","Input","KEGG_GLUTATHIONE_METABOLISM",0.34208,1.04,0.341,423,0.717,"GGT5, GSTA5, ODC1, GGT1, GCLC, MGST1",0.467245621007502,0.1444808443322,FALSE +"H3255","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.23401,-0.707,0.836,8741,0.946,"DGKD, LPL, ALDH1B1, ALDH7A1, GK2, AGPAT4",0.0777937225609836,0.0241088635982073,FALSE +"H3255","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.27066,0.816,0.672,2117,0.906,"PLA2G4A, LPCAT2, PEMT, GPD1L, PLPP1, PLA2G12A, PLPP2, PLD1, CHKB, LPGAT1, MBOAT1, LPCAT1, LYPLA2, LPCAT3, PLA2G15, GPD2, PLPP3, CDS1",0.172630726946175,0.0428718023231869,FALSE +"H3255","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.29789,0.912,0.514,1288,0.859,"PSPH, GCAT, GAMT, MAOA, CTH",0.289036881004724,0.0660068361687577,FALSE +"H3255","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.32917,-0.983,0.425,8556,0.818,"GPI, PGM2, PGK1, ALDH3B1, PKM, ALDH1B1, PGAM1, PGAM4, ALDH1A3, PKLR, PGM1, ALDH7A1, PFKP, ALDH3A1",0.371611069949688,0.087246696328677,FALSE +"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.34442,-1.05,0.364,8563,0.805,"CSGALNACT1, CHST13, CHST7, XYLT1, CHST3",0.438898616350944,0.0942041196321315,FALSE +"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.28566,0.902,0.529,2422,0.829,"HS6ST2, XYLT2, EXT2, GLCE, NDST1, B4GALT7",0.276544327964814,0.0814454694497265,FALSE +"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.4081,1.26,0.174,2980,0.541,"FUT8, B3GNT2, B4GALT3, B4GALT1, B4GAT1",0.7594507517174,0.266802734893431,FALSE +"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.58563,1.77,0.0236,1870,0.277,"SGSH, GUSB, GNS, HEXB, HEXA, NAGLU, HGSNAT",1.62708799702989,0.557520230935551,FALSE +"H3255","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.43302,-1.31,0.155,9836,0.756,"B4GALNT1",0.809668301829709,0.121478204498793,FALSE +"H3255","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.38661,1.2,0.223,1666,0.511,"FUT1, HEXB, HEXA, NAGA",0.651695136951839,0.291579099865287,FALSE +"H3255","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.41006,-1.21,0.222,9621,0.736,"ABO, B3GALT5",0.653647025549361,0.133122185662501,FALSE +"H3255","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.5379,1.65,0.0518,2265,0.321,"PIGA, PIGH, PIGS, PIGO, PIGT, PIGK, GPAA1",1.28567024025477,0.493494967595128,FALSE +"H3255","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.43088,1.33,0.128,3361,0.597,"ACO1, MDH2, MTHFD1L, GRHPR, MTHFD1, CS",0.892790030352132,0.224025668870631,FALSE +"H3255","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.2673,-0.817,0.68,7175,0.814,"MAP2K2, MAPK3, PLA2G2A, MMP2, MAP3K3, ADCY3, ADCY8, PTK2B, GNAQ, ADCY9, SRC, PLCB2, MAP2K3, MAP3K2, PLA2G2D, SOS1, HBEGF, MAP2K7, PLCB4, MAP2K1, RAF1, ELK1, MAPK8, MAP2K4, MAPK10, MAP2K6, CACNA1F, MMP14, PLA2G6",0.167491087293764,0.0893755951107988,FALSE +"H3255","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.57521,-1.73,0.0296,9204,0.532,"CSNK1E, WNT10A, WNT7A, GLI2",1.52870828894106,0.274088367704952,FALSE +"H3255","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.33087,-0.991,0.413,8470,0.83,"CD38, CD59, CD14, IL6, ITGB3, ITGA5, ANPEP, ITGA6, CD33",0.384049948343599,0.0809219076239261,FALSE +"H3255","Input","KEGG_HISTIDINE_METABOLISM",-0.38446,-1.17,0.255,8384,0.718,"LCMT1, MAOB, ALDH3B1, ALDH1B1, ALDH1A3, ALDH7A1, LCMT2, ALDH3A1",0.593459819566045,0.1438755557577,FALSE +"H3255","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.23296,-0.7,0.854,8074,0.947,"RAD54B, BRCA2, RAD51, TOP3B, RAD52",0.068542129310995,0.0236500209967266,FALSE +"H3255","Input","KEGG_HUNTINGTONS_DISEASE",-0.1595,-0.484,0.996,6266,1,"COX7B, NDUFA10, NDUFB3, GPX1, NDUFS1, SDHD, ATP5PO, NDUFA7, COX7C, NDUFB2, NDUFC2, DNAL4, SLC25A4, NDUFA9, CASP3, PLCB3, ATP5F1A, DNAL1, NDUFS2, NDUFB7, BAX, UQCR10, UQCRQ, CASP9, SLC25A5, ATP5F1C, GNAQ, GRM5, GRIN1, PLCB2, HTT, DCTN2, TBPL1, ATP5F1E, SP1, ATP5PB, SOD1, PPARG, CYC1, DCTN4, DCTN1, PLCB4, NDUFA2, CREB5, TGM2, TP53",0.00174066157630127,0,FALSE +"H3255","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.52789,-1.6,0.0641,8939,0.766,"SLC8A1, IL6, CACNA2D1, ITGB3, ITGB1, TGFB2, CACNA1F, ITGA5, TPM2, ITGB8, ITGA6, DES, ACE",1.19314197048118,0.115771230367396,FALSE +"H3255","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.29939,-0.916,0.535,8484,0.849,"PIK3CB, INPP1, PIK3C3, ITPK1, PLCB4, INPPL1, IMPA1, PIP5K1A, PLCD3, PLCG2",0.271646217978772,0.0710923097560473,FALSE +"H3255","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.28823,-0.866,0.588,7895,0.806,"EIF4EBP1, RAPGEF1, SHC1, PHKA2, FOXO1, CBLB, ACACB, RPS6, SOS1, PIK3CB, PHKA1, PHKB, SHC4, INPP5D, MAP2K1, RAF1, ELK1, PHKG2, ARAF, MAPK8, PKLR, MAPK10, MKNK1, CBL, SOCS4, IRS2",0.230622673923862,0.0936649581949093,FALSE +"H3255","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.50237,-1.49,0.0765,8733,0.759,"CXCR4, IL6, CCR10, CCR9, CD40",1.11633856484638,0.11975822410452,FALSE +"H3255","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.29048,0.869,0.6,1009,0.888,"LIFR, OSMR, CCND1, SPRY2, STAM2, EP300, IFNGR1, STAT2, PIAS3",0.221848749616356,0.051587034221399,FALSE +"H3255","Input","KEGG_LEISHMANIA_INFECTION",0.3775,1.15,0.262,787,0.567,"PTGS2, MYD88, MAPK12, TGFB1, TLR2, MAPK13, IFNGR1",0.581698708680255,0.246416941107093,FALSE +"H3255","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.23998,0.743,0.809,1123,0.929,"ICAM1, CLDN3, MAPK12, MAPK13, VAV1, AFDN, ARHGAP35, CTNNB1, OCLN, CLDN4",0.0920514783877277,0.0319842860063582,FALSE +"H3255","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.32649,1,0.42,1824,0.749,"ALDH2, ALDH3A2, EHHADH",0.3767507096021,0.125518182300534,FALSE +"H3255","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.38646,-1.17,0.23,9884,0.718,"PLA2G6",0.638272163982407,0.1438755557577,FALSE +"H3255","Input","KEGG_LONG_TERM_DEPRESSION",0.2406,0.747,0.784,1186,0.952,"PLA2G4A, GUCY1A1, GNAO1, PLCB1, ITPR1, PLA2G12A, ITPR3",0.105683937315562,0.0213630516155257,FALSE +"H3255","Input","KEGG_LONG_TERM_POTENTIATION",0.16611,0.515,0.988,1186,0.993,"EP300, PLCB1, ITPR1, ATF4, PPP3R1, ITPR3",0.00524305541237188,0.00305075150461883,FALSE +"H3255","Input","KEGG_LYSINE_DEGRADATION",0.274,0.85,0.616,1537,0.879,"ALDH2, AASS, DLST, GCDH, ALDH3A2, OGDHL, ACAT2, NSD3, OGDH, SETMAR",0.210419287835575,0.0560111249262281,FALSE +"H3255","Input","KEGG_LYSOSOME",0.59532,1.83,0.0235,1669,0.244,"CTSE, NPC2, NAPSA, LGMN, SGSH, CTSH, LAMP3, CTSC, FUCA1, GALC, PSAP, CTSZ, GUSB, CD63, NEU1, MANBA, ASAH1, GNS, ACP2, GNPTG, ARSA, SCARB2, SMPD1, MFSD8, CLN3, AGA, CLTA, ACP5, MAN2B1, CTSS, NAGPA, HEXB, SORT1, DNASE2, GM2A, HEXA, CTSA, GNPTAB, M6PR, SLC11A2, NAGA, MCOLN1",1.62893213772826,0.612610173661271,TRUE +"H3255","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.33904,-1.04,0.376,8461,0.811,"SOS1, ATF2, PPP3CC, FLNA, RAC2, STMN1, MAP2K7, NLK, CD14, RASA1, MAP2K1, MAPT, ELK4, RAF1, CACNA2D1, ELK1, DUSP4, DUSP1, MAPK8, PTPN7, MAP2K4, MAP4K4, NFKB2, FLNC, MAPK10, RELB, TGFB2, MAP2K6, HSPA2, CACNA1F, MKNK1, STK4, MOS, FGF13, FGF2, PLA2G6, RASGRP2, TP53",0.424812155072339,0.090979145788844,FALSE +"H3255","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.2755,-0.843,0.631,9338,0.813,"PKLR",0.199970640755866,0.0899094544059319,FALSE +"H3255","Input","KEGG_MELANOGENESIS",-0.22541,-0.66,0.891,6728,0.984,"PRKCB, GNAI3, GSK3B, PLCB3, MAP2K2, MAPK3, ADCY3, ADCY8, GNAQ, ADCY9, PLCB2, DCT, FZD2, GNAI2, PLCB4, MAP2K1, RAF1, LEF1, FZD7, WNT10A, WNT7A",0.0501222959631252,0.00700490156865849,FALSE +"H3255","Input","KEGG_MELANOMA",-0.42238,-1.3,0.148,8460,0.744,"HGF, PIK3CB, IGF1R, MAP2K1, RAF1, ARAF, CDKN2A, FGF13, FGF2, TP53",0.829738284605043,0.128427064454121,FALSE +"H3255","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.42542,-1.28,0.185,8919,0.675,"ALDH3B1, GSTM3, GSTM2, ALDH1A3, GSTM1, GSTO1, ALDH3A1, GSTM4, GSTP1",0.732828271596986,0.170696227168975,FALSE +"H3255","Input","KEGG_MISMATCH_REPAIR",0.39045,1.21,0.204,3752,0.528,"SSBP1, RPA3, POLD4, RFC3, LIG1, RFC1, EXO1, MSH3, PCNA, PMS2",0.690369832574101,0.277366077466188,FALSE +"H3255","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.14959,-0.442,0.998,6026,1,"EIF4E2, AKT2, EIF4B, RPS6KA2, RPS6KB1, ULK3, RPS6KA1, MAPK3, TSC2, TSC1, EIF4EBP1, RPS6, PIK3CB, CAB39L",0.000869458712628891,0,FALSE +"H3255","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.30955,-0.934,0.498,8461,0.848,"SOS1, PIK3CB, LAT, PPP3CC, LCK, RAC2, SHC4, MAP2K1, RAF1, SH3BP2, NFATC1, ARAF, TNFRSF10B, TNFRSF10D, ICAM2, NFAT5, PRF1, PLCG2",0.302770657240282,0.0716041477432862,FALSE +"H3255","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.35608,-1.1,0.304,7196,0.823,"PLG, GRM5, GRIN1, PRSS3, NR3C1, F2, F2R, F2RL1",0.517126416391246,0.0846001647877302,FALSE +"H3255","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.31831,-0.95,0.484,7848,0.838,"YWHAB, IRAK1, RAPGEF1, MAGED1, PTPN11, FOXO3, SHC1, YWHAQ, IRAK3, SOS1, PIK3CB, MAP2K7, RIPK2, SHC4, MAP2K1, IRAK2, CSK, YWHAZ, RAF1, IRAK4, MAPK8, MAPK10, PLCG2, NGFR, IRS2, TP53",0.315154638355588,0.0767559813697235,FALSE +"H3255","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.41951,1.27,0.171,364,0.57,"ENPP3, NAMPT, NT5E",0.767003889607846,0.244125144327509,FALSE +"H3255","Input","KEGG_NITROGEN_METABOLISM",-0.51133,-1.53,0.0531,9087,0.72,"CA9, CA12, GLUD2, CA2",1.27490547891853,0.142667503568732,FALSE +"H3255","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.40053,-1.2,0.251,7187,0.736,"MAPK3, RELA, CHUK, TAB1, CASP1, PYDC1, XIAP, CARD8, TAB3, HSP90AB1, RIPK2, IL6, BIRC2, MAPK8, TNFAIP3, MAPK10, SUGT1, IL18, PYCARD",0.600326278518962,0.133122185662501,FALSE +"H3255","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.46002,-1.38,0.132,6350,0.731,"DCLRE1C, RAD50, LIG4, POLL, NHEJ1, PRKDC, FEN1",0.87942606879415,0.13608262304214,FALSE +"H3255","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.35828,-1.11,0.273,8445,0.82,"RASSF1, SOS1, PIK3CB, MAP2K1, RAF1, ARAF, CDKN2A, STK4, PLCG2, TP53",0.563837352959244,0.0861861476162833,FALSE +"H3255","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.21185,0.638,0.925,3247,0.953,"NCOR2, EP300, HES1, DTX2, NOTCH3, CTBP1, HDAC2, MAML2, PSEN1, CREBBP, SNW1, DVL2, ADAM17, NUMB",0.0338582672609674,0.0209070993616736,FALSE +"H3255","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.29256,0.904,0.538,3699,0.859,"POLE2, POLE4, ERCC8, RPA3, MNAT1, POLE, DDB2, POLE3, POLD4, RFC3, GTF2H5, DDB1, LIG1, GTF2H2, RFC1, ERCC2, GTF2H1, PCNA, ERCC4, CDK7",0.269217724333611,0.0660068361687577,FALSE +"H3255","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.39376,1.2,0.223,1704,0.511,"FUT8, ST6GAL1, MGAT4A, MAN1A1, MGAT1, MAN2A2, MOGS, MAN1B1, ALG12, MGAT2, B4GALT3",0.651695136951839,0.291579099865287,FALSE +"H3255","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.2352,-0.724,0.802,7253,0.928,"ADCY3, CNGB1, PDE1C",0.0958256317158365,0.0324520237811379,FALSE +"H3255","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.31526,-0.947,0.437,7361,0.831,"MTFMT, GART, ATIC, MTHFR, ALDH1L1",0.359518563029578,0.080398976215889,FALSE +"H3255","Input","KEGG_OOCYTE_MEIOSIS",-0.26299,-0.797,0.66,6083,0.833,"PRKACB, MAD2L2, CDC16, CDC23, RPS6KA2, PPP2CB, CDC20, ANAPC4, PPP2CA, MAD2L1, PPP1CB, SKP1, SMC3, SMC1A, RPS6KA1, MAPK3, ADCY3, ADCY8, PTTG1, SGO1, CHP1, PPP2R5A, ADCY9, CUL1, CDC25C, YWHAB, PPP2R5D, FBXO5, SLK, ESPL1, CDK2, YWHAQ, CDC26, PPP3CC, PLK1, IGF1R, SMC1B, CDK1, PPP2R1B, MAP2K1, YWHAZ, MOS",0.180456064458131,0.0793549985932124,FALSE +"H3255","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.61298,1.86,0.0203,1326,0.251,"FUCA1, NEU1, MANBA, AGA, MAN2B1, HEXB, HEXA",1.69250396208679,0.600326278518962,FALSE +"H3255","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.19406,-0.576,0.983,5496,1,"NDUFB5, NDUFB9, NDUFS8, NDUFA3, NDUFC1, NDUFS5, NDUFS4, UQCRC2, NDUFV2, NDUFS7, COX4I1, NDUFB4, COX7A2L, UQCRC1, COX11, NDUFA6, NDUFV1, ATP6V1H, COX7B, NDUFA11, NDUFA10, NDUFB3, NDUFS1, SDHD, COX17, ATP5PO, NDUFA7, COX7C, NDUFB2, NDUFC2, ATP12A, NDUFA9, ATP5F1A, ATP6V1C1, NDUFS2, NDUFB7, UQCR10, UQCRQ, ATP5F1C, PPA1, ATP5MG, ATP5ME, ATP5F1E, COX15, TCIRG1, ATP5PB, CYC1, NDUFA2",0.00744648216786438,0,FALSE +"H3255","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.76427,2.36,0,1130,0.0732,"GALNT10, GALNT8, GALNT3, GALNT5, GALNT12, GALNT4, GALNT11, C1GALT1, GALNT6, C1GALT1C1, GALNT1, GALNT13, GALNT7",Inf,1.13548891894161,TRUE +"H3255","Input","KEGG_P53_SIGNALING_PATHWAY",-0.41325,-1.25,0.197,8360,0.668,"CDK2, IGFBP3, ATM, CHEK1, SFN, CDK1, RRM2B, PERP, TNFRSF10B, CDKN2A, SERPINE1, SERPINB5, TP53",0.705533773838407,0.175223537524454,FALSE +"H3255","Input","KEGG_PANCREATIC_CANCER",-0.28805,-0.874,0.578,8296,0.799,"RAD51, PIK3CB, ARHGEF6, RAC2, MAP2K1, RAF1, ARAF, MAPK8, MAPK10, TGFB2, CDKN2A, TP53",0.238072161579471,0.0974532206860086,FALSE +"H3255","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.64565,1.98,0.00428,1,0.292,"ENPP3",2.36855623098683,0.534617148551582,FALSE +"H3255","Input","KEGG_PARKINSONS_DISEASE",-0.27526,-0.819,0.65,5677,0.83,"NDUFC1, NDUFS5, NDUFS4, UQCRC2, NDUFV2, NDUFS7, UBE2L3, COX4I1, NDUFB4, COX7A2L, UQCRC1, NDUFA6, NDUFV1, SLC25A6, COX7B, NDUFA10, NDUFB3, NDUFS1, SDHD, ATP5PO, NDUFA7, COX7C, NDUFB2, NDUFC2, PARK7, SLC25A4, NDUFA9, CASP3, ATP5F1A, NDUFS2, NDUFB7, UQCR10, UQCRQ, CASP9, SLC25A5, ATP5F1C, ATP5F1E, SLC18A1, ATP5PB, CYC1, UBA1, NDUFA2, UCHL1, UBA7, SNCA",0.187086643357144,0.0809219076239261,FALSE +"H3255","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.31893,-0.962,0.45,8221,0.823,"FYN, NCK1, YWHAQ, TUBA3C, TUBB4B, NCK2, CD14, YWHAZ, TUBAL3, WAS, ITGB1, TUBB6",0.346787486224656,0.0846001647877302,FALSE +"H3255","Input","KEGG_PATHWAYS_IN_CANCER",-0.36469,-1.09,0.314,8201,0.825,"AXIN2, FZD2, CBLB, RAD51, VHL, CDK2, PPARG, TRAF2, RASSF1, HGF, SOS1, PIK3CB, TFG, IGF1R, RAC2, MMP1, APPL1, HSP90AB1, PAX8, STAT5A, MAP2K1, IL6, RAF1, SLC2A1, EGLN1, ARAF, BIRC2, MAPK8, LEF1, PML, NFKB2, ETS1, MAPK10, FADD, ITGB1, TGFB2, LAMA3, LAMA4, FZD7, WNT10A, CDKN2A, STK4, COL4A1, CBL, COL4A6, ITGA6, WNT7A, PLCG2, COL4A2, GLI2, FGF13, FGF2, GSTP1, TP53, BIRC5",0.503070351926785,0.0835460514500749,FALSE +"H3255","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.62983,1.99,0.00798,1816,0.415,"GUSB, DCXR, AKR1B1, UGDH",2.09799710864927,0.381951903287907,FALSE +"H3255","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.29539,0.902,0.545,173,0.829,"FBP1, FBP2",0.263603497723358,0.0814454694497265,FALSE +"H3255","Input","KEGG_PEROXISOME",0.44275,1.35,0.138,2246,0.63,"AMACR, ACSL5, SLC27A2, ECI2, ACAA1, ECH1, CROT, PECR, DHRS4, PEX16, PXMP4, PEX13, ACOT8, DECR2, PEX6, ACOX1, PEX2, ACSL1, PEX3, IDH2, EHHADH, ACSL4, IDH1, SCP2, MPV17, GSTK1, MVK, PEX26, PEX1",0.860120913598763,0.200659450546418,FALSE +"H3255","Input","KEGG_PHENYLALANINE_METABOLISM",-0.51143,-1.57,0.0684,6281,0.755,"PRDX6, GOT1, MIF, TAT, GOT2, MAOB, ALDH3B1, ALDH1A3, ALDH3A1",1.16494389827988,0.122053048370812,FALSE +"H3255","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.29616,-0.903,0.528,7419,0.853,"PIP5K1C, DGKB, DGKQ, PI4KB, PLCB2, SYNJ2, PIP4K2B, DGKE, PIK3CB, INPP1, PIK3C3, ITPK1, DGKD, PLCB4, INPPL1, INPP5D, IMPA1, PIP5K1A, PLCD3, PLCG2",0.277366077466188,0.069050968832477,FALSE +"H3255","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.36222,1.11,0.3,1507,0.626,"CP, GUSB, ALAD, BLVRA, HMOX1, CPOX",0.522878745280338,0.20342566678957,FALSE +"H3255","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.45538,-1.35,0.149,9042,0.726,"SLC27A1, FABP7, LPL, SCD, ACADL, GK2, CYP27A1, PLTP, FABP5, OLR1, ANGPTL4",0.826813731587726,0.139063379299906,FALSE +"H3255","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.56543,1.74,0.0266,1022,0.281,"AMACR, AKR1D1, HSD3B7",1.57511836336893,0.55129368009492,FALSE +"H3255","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.59581,-1.77,0.0356,8500,0.797,"RFX5, LCK, RFXAP, BLNK, CD79A, CD40",1.44855000202712,0.0985416786038876,FALSE +"H3255","Input","KEGG_PRION_DISEASES",-0.46458,-1.4,0.108,8221,0.726,"FYN, SOD1, MAP2K1, IL6, ELK1, PRNP, NOTCH1, NCAM1",0.96657624451305,0.139063379299906,FALSE +"H3255","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.32346,-0.994,0.407,8360,0.838,"CDK2, GNAI2, CDC26, PIK3CB, PLK1, IGF1R, HSP90AB1, CDK1, MAP2K1, RAF1, ARAF, MAPK8, MAPK10, MOS",0.39040559077478,0.0767559813697235,FALSE +"H3255","Input","KEGG_PROPANOATE_METABOLISM",0.31766,1.01,0.411,2228,0.746,"ALDH2, ALDH6A1, ALDH3A2, ACSS1, LDHB, ACAT2, ACSS2, EHHADH, HIBCH, PCCA, SUCLG2",0.386158178123931,0.127261172527331,FALSE +"H3255","Input","KEGG_PROSTATE_CANCER",-0.24203,-0.724,0.79,8360,0.928,"CDK2, SOS1, PIK3CB, IGF1R, HSP90AB1, MAP2K1, RAF1, ARAF, CREB5, LEF1, GSTP1, TP53",0.102372908709559,0.0324520237811379,FALSE +"H3255","Input","KEGG_PROTEASOME",-0.30056,-0.886,0.565,5469,0.818,"PSMD11, PSMB1, PSMA8, PSME3, PSMD8, PSMB4, PSMA7, PSMD13, PSMD7, PSME4, PSMA6, PSMA4, PSMD6, PSMD1, PSMB2, SEM1, PSME2, PSMD3, PSMD12, PSMB8, PSME1, POMP, PSMB10, PSMB9",0.247951552180562,0.087246696328677,FALSE +"H3255","Input","KEGG_PROTEIN_EXPORT",0.24929,0.781,0.749,2140,0.932,"SRP9, SEC62, IMMP2L, SRP14, OXA1L",0.125518182300534,0.0305840876460186,FALSE +"H3255","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.47046,-1.45,0.0895,9872,0.65,"GLUD2, CA2",1.04817696468409,0.187086643357144,FALSE +"H3255","Input","KEGG_PURINE_METABOLISM",0.27566,0.86,0.605,1176,0.891,"ENPP3, ENTPD3, GUCY1A1, ENTPD5, PDE4A, NME4, NT5E, FHIT, POLE2, POLE4, PAPSS2, PDE2A, ENTPD6, CANT1, ADCY10",0.218244625347531,0.0501222959631252,FALSE +"H3255","Input","KEGG_PYRIMIDINE_METABOLISM",0.25348,0.774,0.725,1136,0.931,"ENTPD3, ENTPD5, NME4, NT5E, TXNRD2, UPP1, POLE2, POLE4, UCK1, ENTPD6, CANT1, CTPS2",0.139661993429006,0.0310503190186574,FALSE +"H3255","Input","KEGG_PYRUVATE_METABOLISM",0.24477,0.727,0.8,1366,0.929,"ALDH2, ME1, ALDH3A2, ACSS1, MDH2, LDHB, ACAT2, ACSS2",0.0969100130080564,0.0319842860063582,FALSE +"H3255","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.38963,-1.15,0.277,8086,0.743,"PAK2, PIP4K2B, MSN, ARHGEF7, PAK3, F2, F2R, SOS1, PIK3CB, ARHGEF6, RAC2, DIAPH1, VCL, BCAR1, NCKAP1, BAIAP2, CYFIP1, DOCK1, CD14, MAP2K1, CSK, RAF1, DIAPH3, ARAF, ITGB3, RDX, MYLK, WAS, ITGB1, PIP5K1A, ITGA5, MOS, DIAPH2, ITGB8, ITGA6, FGF13, FGF2, ARHGEF4",0.557520230935551,0.129011186239425,FALSE +"H3255","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.41874,-1.28,0.155,7595,0.675,"BECN1, GABARAPL1, PIK3C3, ATG3, GABARAPL2, ATG7",0.809668301829709,0.170696227168975,FALSE +"H3255","Input","KEGG_RENAL_CELL_CARCINOMA",-0.27462,-0.817,0.662,7685,0.814,"CUL2, RAP1B, RAPGEF1, PTPN11, PAK2, PAK3, VHL, HGF, SOS1, PIK3CB, MAP2K1, RAF1, SLC2A1, EGLN1, ARAF, ETS1, TGFB2",0.1791420105603,0.0893755951107988,FALSE +"H3255","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.64205,-1.88,0.0137,9597,0.999,"ANPEP, CPA3, ACE",1.86327943284359,0.000434511774017692,FALSE +"H3255","Input","KEGG_RETINOL_METABOLISM",0.27614,0.849,0.615,1532,0.865,"RDH11, DHRS3, DHRS4, CYP3A4",0.211124884224583,0.0629838925351858,FALSE +"H3255","Input","KEGG_RIBOFLAVIN_METABOLISM",0.6086,1.86,0.0188,904,0.251,"ENPP3, ACP2, ACP5",1.72584215073632,0.600326278518962,FALSE +"H3255","Input","KEGG_RIBOSOME",-0.59276,-1.77,0.0368,6387,0.797,"RPL37A, RPS4X, FAU, RPL24, RSL24D1, RPL23, RPS5, RPS19, RPL27, RPS15, RPL3, RPL21, RPS17, RPL29, RPL15, RPL23A, RPS8, RPL35, RPS3A, RPL30, RPS13, RPL35A, RPL8, RPL27A, RPL5, RPL32, RPS3, RPL18, RPL36A, RPL36AL, RPS9, RPL18A, RPS15A, RPS25, RPS7, RPL26, RPL38, RPL28, RPL6, RPS24, RPL22, RPL34, RPL17, RPS2, RPL11, RPL9, RPS18, RPL13A, RPL4, RPL31, RPS16, RPS29, RPS20, RPL19, RPL10A, RPS6, RPL14, RPS11, RPL37, RPL7A, RPS23, RPL7, UBA52, RPL36, RPS27L, RPS4Y1",1.43415218132648,0.0985416786038876,FALSE +"H3255","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.21217,0.65,0.909,741,0.954,"MAPK12, IRF7, MAPK13, DDX58, CASP10",0.0414361167780325,0.0204516252959049,FALSE +"H3255","Input","KEGG_RNA_DEGRADATION",-0.35406,-1.07,0.333,6817,0.814,"CNOT4, CNOT9, PARN, DCP1A, CNOT7, EXOSC5, CNOT2, PAPOLG, EXOSC10, CNOT1, EXOSC3, DDX6, MTREX, ENO3, XRN1, CNOT6L, PATL1, EDC3, MPHOSPH6, CNOT6, DIS3, DCPS, C1D",0.47755576649368,0.0893755951107988,FALSE +"H3255","Input","KEGG_RNA_POLYMERASE",-0.19527,-0.594,0.964,1932,1,"POLR2J, POLR3GL, POLR1E, POLR3G, POLR2D, POLR2G, POLR2I, POLR2F, POLR2E, POLR2C, POLR2K, POLR2L, POLR2H, POLR1B, POLR1A, POLR2A, POLR3C, POLR1C, POLR1D, POLR2B, POLR3D, POLR3F, POLR3K, POLR3H, POLR3A, POLR3B",0.0159229660971692,0,FALSE +"H3255","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.43698,1.32,0.135,1288,0.555,"GGT5, GGT1, PAPSS2, TRMT11, CTH",0.869666231504994,0.255707016877324,FALSE +"H3255","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.34335,-1.03,0.381,9225,0.802,"BIRC2, ITGB1, LAMA3, LAMA4, COL4A1, COL4A6, ITGA6, COL4A2, TP53",0.419075024324381,0.0958256317158365,FALSE +"H3255","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.41183,1.24,0.211,1992,0.514,"VTI1B, GOSR2, STX16, STX8, BET1L, GOSR1, STX17, VAMP4, STX6, VAMP8, TSNARE1",0.675717544702307,0.289036881004724,FALSE +"H3255","Input","KEGG_SPHINGOLIPID_METABOLISM",0.48964,1.52,0.084,908,0.404,"GALC, NEU1, ASAH1, ARSA, SMPD1, SGPP1, PLPP1, PLPP2",1.07572071393812,0.393618634889395,FALSE +"H3255","Input","KEGG_SPLICEOSOME",0.32927,0.99,0.433,3991,0.754,"HSPA6, ISY1, SRSF9, SF3B5, NCBP2, DDX42, DDX23, SRSF5, PRPF19, PRPF40A, SF3A1, TRA2A, SNRPG, PQBP1, HSPA1A, BCAS2, LSM2, PPIL1, HNRNPA1, CDC5L, SRSF8, SNRPB2, CDC40, SYF2, PPIE, PHF5A, PLRG1, SART1, WBP11, U2AF1, SRSF2, SRSF4, CCDC12, SNRNP200, LSM8, ACIN1, TRA2B, SNRPF, SRSF3, SNW1, HNRNPA3, SRSF1, TXNL4A, SRSF7, HSPA1L, SNRNP40, RBM8A, RBMX, PRPF6, HNRNPM, SNRPB, DDX5, EFTUD2, SF3B2, U2AF2, THOC3, RBM17, LSM7, HNRNPK, SNRPA1, SF3B3, XAB2, LSM6, SF3A3",0.363512103646635,0.122628654130226,FALSE +"H3255","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.4374,1.32,0.146,258,0.555,"ENPP3, GUSB",0.835647144215563,0.255707016877324,FALSE +"H3255","Input","KEGG_STEROID_BIOSYNTHESIS",0.63439,1.97,0.0081,2032,0.229,"DHCR24, DHCR7, LSS, TM7SF2, FDFT1, CYP27B1, CYP51A1, SOAT2, MSMO1, SC5D",2.09151498112135,0.640164517660112,TRUE +"H3255","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.49854,1.53,0.064,1835,0.421,"SULT2B1, AKR1D1, SRD5A3, HSD11B2, STS, HSD17B12, COMT, AKR1C3, HSD17B8, CYP3A4, AKR1C1",1.19382002601611,0.375717904164332,FALSE +"H3255","Input","KEGG_SULFUR_METABOLISM",0.53852,1.66,0.0538,707,0.34,"SULT2B1, SUOX, PAPSS2",1.26921772433361,0.468521082957745,FALSE +"H3255","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.57395,-1.74,0.0405,9353,0.596,"C1S, TRIM21, C3, CD40",1.39254497678533,0.224753740259764,FALSE +"H3255","Input","KEGG_TASTE_TRANSDUCTION",0.26359,0.798,0.694,3980,0.913,"ITPR3, GNB3, GNAS, ADCY6, PRKACA, CACNA1A",0.158640529545145,0.039529222465701,FALSE +"H3255","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.42654,1.33,0.151,1331,0.597,"PDSS2, HMGCS1, HMGCR, ACAT2",0.821023052706831,0.224025668870631,FALSE +"H3255","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.28957,-0.877,0.578,6712,0.815,"SMAD1, E2F4, SKP1, SMAD5, SMAD4, TGFBR1, AMH, MAPK3, MYC, SMAD2, CUL1, BMPR2, SP1, ID1, INHBA, PPP2R1B, SMAD9, TFDP1, BMPR1A, TGFB2",0.238072161579471,0.0888423912600234,FALSE +"H3255","Input","KEGG_THYROID_CANCER",-0.34566,-1.05,0.347,8378,0.805,"PPARG, TFG, PAX8, MAP2K1, LEF1, TP53",0.459670525209126,0.0942041196321315,FALSE +"H3255","Input","KEGG_TIGHT_JUNCTION",0.24142,0.733,0.82,2180,0.933,"CLDN3, PATJ, CRB3, EPB41L3, PRKCH, AFDN, CTNNB1, CGN, OCLN, CLDN4, TJP3, MYH2, MPDZ, MAGI3, PARD6A, MYH7, MYH3, CTNNA1, TJP2, HRAS, PRKCI, PARD6G, AKT1",0.0861861476162833,0.0301183562535,FALSE +"H3255","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.25273,0.753,0.772,558,0.956,"LY96, MYD88, MAPK12, TLR2, IRF7, TOLLIP, MAPK13",0.112382699664264,0.0195421077238999,FALSE +"H3255","Input","KEGG_TRYPTOPHAN_METABOLISM",0.31548,0.961,0.433,1824,0.783,"ALDH2, GCDH, ALDH3A2, MAOA, OGDHL, ACAT2, OGDH, EHHADH",0.363512103646635,0.106238237942057,FALSE +"H3255","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.50204,-1.55,0.0599,9126,0.733,"PKM, MAPK8, PKLR, MAPK10, SOCS4, IRS2",1.22257317761069,0.134896025358872,FALSE +"H3255","Input","KEGG_TYROSINE_METABOLISM",-0.43489,-1.34,0.126,6964,0.716,"MIF, TAT, ADH5, ADH1C, METTL2B, GOT2, DCT, LCMT1, MAOB, ALDH3B1, ALDH1A3, HGD, LCMT2, ALDH3A1",0.899629454882437,0.145086977692144,FALSE +"H3255","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.28586,-0.845,0.631,8086,0.829,"PAK2, PAK3, FYN, CBLB, NCK1, SOS1, PIK3CB, LAT, PPP3CC, LCK, NCK2, MAP2K7, BCL10, MAP2K1, RAF1, NFATC1, CARD11, MALT1, PRKCQ, NFAT5, CBL",0.199970640755866,0.0814454694497265,FALSE +"H3255","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.27742,-0.837,0.64,7165,0.814,"SIAH1, UBE2K, NEDD4, UBE2M, UBE2B, RNF7, UBA3, MID1, CUL2, CUL1, COP1, HERC3, XIAP, UBE4B, UBE4A, KEAP1, CBLB, CUL4A, VHL, WWP1, UBE2F, CDC26, UBE2Q1, UBE2E2, UBA1, UBE2D2, CUL4B, CUL5, HUWE1, BIRC2, PML, HERC4, UBE2E1, UBA7, CBL, FBXO2",0.193820026016113,0.0893755951107988,FALSE +"H3255","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.27274,-0.834,0.648,5944,0.81,"PDHB, VARS2, PDHA1, LARS2",0.188424994129407,0.0915149811213502,FALSE +"H3255","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.5036,1.54,0.0789,1996,0.438,"ACAD8, OXCT1, ALDH2, ALDH6A1, HMGCS1, ACAA1, IVD, BCKDHA, ALDH3A2, HIBADH, BCKDHB, ACAT2, BCAT2, ACADSB, EHHADH, HIBCH, PCCA",1.10292299679058,0.3585258894959,FALSE +"H3255","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.28456,-0.879,0.586,8757,0.821,"PLCB4, MAP2K1, RAF1, ARAF, MYLK, CACNA1F, PRKCQ, CALD1, PLA2G6",0.232102383981909,0.0856568428805592,FALSE +"H3255","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.1831,-0.548,0.99,6922,1,"DYNLL2, DYNC1LI1, ADCY3, DYNC1H1, VAMP2, ADCY9, DCTN5, DYNC2LI1, DCTN2, STX4, RAB11A, DCTN4, DCTN1, CREB5",0.00436480540245009,0,FALSE +"H3255","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.23102,0.698,0.864,1254,0.947,"PTGS2, PLA2G4A, MAPK12, MAPK13, PLA2G12A, VEGFA, PPP3R1, BAD",0.0634862575211067,0.0236500209967266,FALSE +"H3255","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.22932,0.69,0.868,3387,0.919,"PDIA4, ERO1A, KDELR1, SLC12A2, ATP6V1F, TJP2, ATP6AP1, GNAS, TJP1, ATP6V1G1, ATP6V1B1, ATP6V1E1, ATP6V1B2, ATP6V0A1, ACTB",0.0614802748235081,0.0366844886138887,FALSE +"H3255","Input","KEGG_VIRAL_MYOCARDITIS",0.22327,0.692,0.855,499,0.929,"ICAM1, CCND1, CD55",0.0680338852718274,0.0319842860063582,FALSE +"H3255","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.3,-0.89,0.558,7165,0.845,"SIAH1, CSNK2A1, CSNK2A2, MYC, CHP1, PPP2R5A, NFATC3, SMAD2, PLCB2, RAC3, CUL1, CACYBP, VANGL1, PPP2R5D, AXIN2, FZD2, PPP3CC, PORCN, RAC2, PLCB4, NLK, PPP2R1B, MMP7, NFATC1, CSNK1E, MAPK8, LEF1, MAPK10, SOX17, FZD7, WNT10A, FOSL1, NFAT5, WNT7A, TP53",0.253365801062421,0.0731432910503077,FALSE +"H358","Input","KEGG_ABC_TRANSPORTERS",-0.6212,-1.91,0.0143,7484,0.183,"ABCB4, ABCB7, ABCB6, ABCC5, ABCA1, ABCD1, ABCC3, ABCC6, ABCB1, ABCA3, ABCB10, ABCB8, ABCC2, ABCB11",1.84466396253494,0.737548910269571,TRUE +"H358","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.22332,0.687,0.845,1293,0.895,"PIK3R3, PIK3CD, RPS6KB2, RUNX1, CCND1, KRAS, NRAS, RPS6KB1, PIK3CA",0.0731432910503077,0.048176964684088,FALSE +"H358","Input","KEGG_ADHERENS_JUNCTION",0.44542,1.33,0.134,1897,0.515,"RAC2, CDH1, CTNNA1, CTNND1, CTNNB1, CTNNA2, BAIAP2, LMO7, PTPRF, NECTIN4, ERBB2, SMAD3, RAC3, FARP2, MET, CSNK2A1, CSNK2A2, TJP1, PTPRJ, IGF1R, EP300, CREBBP, CSNK2B, ACTN4, NECTIN3, CDC42, YES1, PTPRB",0.872895201635192,0.288192770958809,FALSE +"H358","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.37773,1.17,0.243,940,0.499,"IRS1, SLC2A1, RXRA, MAPK10, MAPK9, RXRG, ADIPOR1, RXRB",0.614393726401688,0.30189945437661,FALSE +"H358","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.64866,-1.99,0.00567,8106,0.198,"ASNS, GPT, AGXT, ALDH5A1, GLS, GLS2, CPS1, GOT1, ALDH4A1, ASS1, ABAT, NIT2",2.24641694110709,0.703334809738469,TRUE +"H358","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.43781,1.37,0.116,409,0.624,"IRS1, SLC9A3R2, PIK3R3, SCNN1B, ATP1B1, PIK3CD",0.935542010773082,0.204815410317576,FALSE +"H358","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.6165,1.9,0.0172,974,0.488,"PLA2G4A, PLA2G12A",1.76447155309245,0.311580177997289,FALSE +"H358","Input","KEGG_ALZHEIMERS_DISEASE",-0.30126,-0.926,0.515,6143,0.683,"MAPK3, ATP5PO, NDUFS7, NDUFB6, ATP5PF, NDUFV1, COX6A1, NDUFS2, NDUFB10, ERN1, LRP1, ATP5F1E, NDUFV3, NDUFA8, NDUFS4, ATP5PB, GRIN1, NDUFA10, ATP5F1D, GNAQ, COX7A2L, GSK3B, NDUFA7, NDUFB2, COX6B1, MAPK1, ATP5F1B, CASP9, NDUFS6, NDUFV2, BID, ATP5PD, NDUFS3, ITPR3, APOE, ATP5F1C, NDUFS8, UQCRB, CYCS, ATP5F1A, GAPDH, APAF1, NDUFA5, UQCRC1, CDK5, PPP3CC, ATP5MC2, UQCRFS1, IDE, ITPR1, UQCRC2, ITPR2, SNCA, MAPT",0.288192770958809,0.165579296318467,FALSE +"H358","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.3828,-1.2,0.221,5801,0.387,"FARSA, NARS2, VARS2, FARSB, AARS2, TARS2, DARS2, CARS2, EARS2, RARS2",0.655607726314889,0.412289034981089,FALSE +"H358","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.45595,-1.41,0.0939,6602,0.314,"UGP2, NAGK, GMPPA, GCK, MPI, GNE, GFPT1, HEXA, CYB5R3, NANS, PMM1, GNPDA1, GPI, UAP1, CYB5R1, RENBP, GALK1, CMAS, UXS1, PGM3, HEXB",1.02733440773389,0.503070351926785,FALSE +"H358","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.43894,-1.36,0.125,7699,0.323,"CYCS, APAF1, CASP1, CAT, MAPK12, MAPK11, BAX, CCS, PPP3CC, SOD1, NEFL, NEFM, TP53, PRPH, PRPH2, NEFH",0.903089986991944,0.490797477668897,FALSE +"H358","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.19338,0.593,0.969,2816,0.977,"PSME1, PSME2, B2M, HSPA2, PSME3, NFYC, NFYB, CREB1, HSPA1A, HSP90AB1, TAPBP, HSP90AA1, TAP1",0.0136762229492347,0.0101054362812269,FALSE +"H358","Input","KEGG_APOPTOSIS",0.24267,0.763,0.759,1584,0.821,"PIK3R3, TNFRSF10A, PIK3CD, CAPN2, PPP3CA, CASP6, PPP3R2, ENDOD1, PPP3R1, ENDOG, PIK3CA, FAS, CHP1, CAPN1, BAD",0.11975822410452,0.0856568428805592,FALSE +"H358","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.38862,-1.22,0.227,7465,0.369,"GPX4, TBXAS1, GGT7, GGT1, GPX2, CBR3, CBR1, GPX6, GPX7, AKR1C3, ALOX5",0.643974142806877,0.43297363384094,FALSE +"H358","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.43376,-1.35,0.137,8508,0.318,"AGMAT, GLS, GLS2, CPS1, CKMT2, GOT1, SAT1, ALDH4A1, MAOB, ASS1, ALDH2, ARG2, CKMT1A",0.863279432843593,0.497572880015567,FALSE +"H358","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.30731,0.941,0.482,1649,0.735,"ITGB6, ITGB4, ITGA3, CTNNA1, LMNA, CTNNB1, CTNNA2, DSC2, DAG1, ITGB5, ITGA6, ATP2A2, DMD, DSG2, ITGA2, ACTN4",0.31695296176115,0.133712660915805,FALSE +"H358","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.37767,-1.17,0.231,7819,0.413,"ALDH7A1, ALDH2",0.636388020107856,0.384049948343599,FALSE +"H358","Input","KEGG_AXON_GUIDANCE",0.41139,1.29,0.161,1123,0.535,"RAC2, EPHA2, SEMA7A, EPHB2, SEMA3A, EPHA6, SEMA4B, EPHA1, RASA1, EPHB3, PPP3CA, EPHA5, EPHA4, SEMA4C, RAC3, NRP1, NGEF, PPP3R2, MET, KRAS, NRAS, EFNB2, PPP3R1",0.79317412396815,0.271646217978772,FALSE +"H358","Input","KEGG_BASAL_CELL_CARCINOMA",-0.49233,-1.52,0.0788,6906,0.242,"GSK3B, FZD7, FZD1, DVL3, DVL2, STK36, TCF7L2, LEF1, WNT16, TP53, WNT11",1.10347378251044,0.616184634019569,FALSE +"H358","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.32691,1.02,0.366,3472,0.645,"GTF2E2, TAF9B, GTF2B, TAF6L, TAF1, GTF2E1, GTF2IRD1, GTF2I, TAF5L, TAF5, GTF2F1, TAF6, TAF4, TAF2, GTF2A1",0.436518914605589,0.190440285364732,FALSE +"H358","Input","KEGG_BASE_EXCISION_REPAIR",0.59343,1.84,0.0215,2035,0.375,"TDG, PCNA, POLD3, PARP2, NEIL2, UNG, FEN1, POLD1, LIG1, POLE3, MUTYH, APEX1, POLD2, APEX2, POLE2, POLB",1.66756154008439,0.425968732272281,FALSE +"H358","Input","KEGG_BETA_ALANINE_METABOLISM",-0.58564,-1.81,0.0165,6587,0.19,"SRM, ECHS1, ALDH1B1, ACADM, DPYD, MLYCD, ALDH7A1, EHHADH, ALDH2, ABAT",1.78251605578609,0.721246399047171,TRUE +"H358","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29329,0.902,0.564,1225,0.748,"HACD1, ELOVL5, ELOVL6, FADS1",0.248720896016658,0.126098402135539,FALSE +"H358","Input","KEGG_BLADDER_CANCER",0.36401,1.1,0.322,1089,0.54,"CDH1, THBS1, RB1, CCND1, ERBB2, KRAS, NRAS",0.492144128304169,0.267606240177031,FALSE +"H358","Input","KEGG_BUTANOATE_METABOLISM",-0.51511,-1.57,0.0551,7819,0.224,"ALDH7A1, ACADS, HMGCS1, AKR1B10, ACAT2, ALDH5A1, EHHADH, HMGCS2, ALDH2, ABAT",1.25884840114821,0.649751981665837,FALSE +"H358","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.31463,0.945,0.478,1362,0.742,"RAC2, PIK3R3, LYN, PIK3CD, PPP3CA, RAC3, PPP3R2, KRAS, NRAS, PPP3R1, PIK3CA, CHP1",0.320572103387881,0.129596094720973,FALSE +"H358","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2962,0.913,0.494,1857,0.78,"TNNC1, TNNC2, LTB4R2, PPP3CA, ERBB2, PLCB1, PTK2B, MYLK, PPP3R2, HRH1, CAMK2D, CACNA1A, PPP3R1, CAMK2G, CHP1, ERBB3, PRKCG, ATP2A2, ERBB4, PHKB, PPP3CB, ATP2B1, PHKA1",0.306273051076353,0.10790539730952,FALSE +"H358","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.29258,0.901,0.549,1505,0.738,"TNNC1, ATP1B1, SLC9A6, CYC1, SLC9A1, MYL3, UQCR10, ATP2A2",0.260427655549908,0.131943638176958,FALSE +"H358","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.46036,1.41,0.129,602,0.725,"CLDN7, CDH15, CDH3, ITGB2, CLDN4, SDC4, SDC1, CDH1, CD274, F11R, CNTN1, CLDN3, PTPRF, CD276, SDC2",0.889410289700751,0.139661993429006,FALSE +"H358","Input","KEGG_CELL_CYCLE",0.4905,1.49,0.0972,1942,0.735,"FZR1, CDC20, CCNA2, MCM4, MCM7, ORC6, CHEK1, MCM5, MCM6, MCM3, BUB1, PCNA, CCNB1, RB1, PLK1, CCND1, CCNB2, SMAD3, MAD2L1, MCM2, SKP2, RBL1, BUB1B, TGFB2, CDC45, CDK1, CDK2, YWHAZ, CDC7, EP300, STAG2, CREBBP, RAD21, SMC3, SFN, CDC6, ESPL1, TTK, TFDP1, SMC1A, BUB3, ORC4, RBX1, PRKDC, YWHAQ, SMC1B",1.01233373507373,0.133712660915805,FALSE +"H358","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.26252,0.802,0.699,1326,0.796,"RAC2, PIK3R3, HCK, LYN, PIK3CD, GNG10, GRK2, PLCB1, PTK2B, GNG5, KRAS, NRAS, PRKCD, BCAR1, PIK3CA, PRKCZ",0.155522824254319,0.0990869322623309,FALSE +"H358","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.22527,-0.716,0.851,8017,0.91,"PIK3R1, CRKL, TGFB1, TGFB3, MAP2K2, CDKN2A, PIK3CB, CDKN1B, CRK, SOS1, TP53",0.0700704399154121,0.0409586076789064,FALSE +"H358","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.40871,-1.24,0.188,7527,0.352,"OGDH, PC, IDH1, OGDHL, ACO2, IDH2, PCK2",0.72584215073632,0.453457336521869,FALSE +"H358","Input","KEGG_COLORECTAL_CANCER",0.36981,1.15,0.271,1702,0.505,"RAC2, PIK3R3, CTNNB1, PIK3CD, MAPK10, MAPK9, CCND1, MSH6, SMAD3, MSH2, RAC3, TGFB2, KRAS, PIK3CA, MLH1, BAD, MSH3",0.567030709125594,0.296708621881339,FALSE +"H358","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.45796,-1.41,0.112,7947,0.314,"CFD, C3, FGB, PROS1, SERPIND1, SERPINE1, THBD, C5, F5, SERPINA1, C4A, SERPINF2, C9, SERPING1, A2M, PLG",0.950781977329818,0.503070351926785,FALSE +"H358","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.19193,-0.6,0.952,6360,0.972,"MAT2B, MTR, SRM, MTAP, SDS, APIP, MPST, ADI1, GOT1, CDO1",0.0213630516155257,0.0123337350737254,FALSE +"H358","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.35815,-1.08,0.324,7654,0.505,"IFNGR1, KIT, LEPR, IL17RA, CSF2RA, TGFB1, OSM, TGFB3, CD70, IL25, HGF, NGFR, IFNAR2, INHBE, IL6",0.489454989793388,0.296708621881339,FALSE +"H358","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.32932,-1.02,0.384,9147,0.539,"ZBP1, PYCARD, IL6",0.415668775632469,0.268411234813261,FALSE +"H358","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.31951,-0.972,0.447,8449,0.615,"SGCB, TGFB3, ITGB8, TPM2, ITGB3, ACTG1, SGCD, ITGA5, ITGA7, DES, ITGA4",0.349692476868064,0.211124884224583,FALSE +"H358","Input","KEGG_DNA_REPLICATION",0.71474,2.21,0.00615,1339,0.289,"MCM4, MCM7, POLA1, PRIM1, MCM5, MCM6, MCM3, PRIM2, PCNA, POLD3, RFC3, FEN1, POLD1, LIG1, MCM2, RFC4, POLA2, RFC5, POLE3, RFC2, RNASEH2A, DNA2, RNASEH2B, POLD2",2.21112488422458,0.539102157243452,FALSE +"H358","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.41391,1.25,0.196,1088,0.505,"NOTCH3, ETS1, KRAS",0.707743928643524,0.296708621881339,FALSE +"H358","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.44433,-1.38,0.107,8249,0.338,"GSTO1, CYP3A5, MGST3, GSTK1, MAOB, GSTM3, GSTM1, GSTM2, GSTM4",0.97061622231479,0.471083299722345,FALSE +"H358","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.29305,-0.908,0.539,8083,0.708,"GUSB, CYP3A5, CES1, CES2, UMPS, TPMT, NAT2",0.268411234813261,0.149966742310231,FALSE +"H358","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.37486,1.14,0.268,273,0.497,"ITGB6, LAMC2, TNC, ITGB4, SDC4, SDC1, ITGA3, LAMB3, LAMA5, AGRN, THBS1",0.571865205971211,0.303643611266668,FALSE +"H358","Input","KEGG_ENDOCYTOSIS",-0.2565,-0.786,0.715,6243,0.849,"AP2M1, SH3GL1, RNF41, IQSEC1, ACAP3, CHMP4A, CHMP4B, CLTB, RAB4A, PDCD6IP, EPN1, RAB5B, RBSN, SRC, AP2S1, PIP4K2B, RAB11FIP5, CBLB, EHD3, VPS36, STAM2, VTA1, PARD6G, VPS37C, HGS, PARD3, ARRB1, ASAP3, VPS4B, EPS15, PIP5K1C, CHMP3, PARD6B, DAB2, ARFGAP2, TRAF6, KIT, EEA1, PIKFYVE, ACAP2, VPS25, FGFR3, PRKCI, FGFR4, SNF8, ARFGAP1, ARFGAP3, CHMP5, DNM1L, ARRB2, ASAP2, DNM2, PLD1, GIT2, AP2A2, RABEP1, VPS37A, STAM, SH3GL2",0.145693958198919,0.0710923097560473,FALSE +"H358","Input","KEGG_ENDOMETRIAL_CANCER",0.34581,1.07,0.314,1584,0.567,"CDH1, CTNNA1, PIK3R3, CTNNB1, CTNNA2, PIK3CD, CCND1, ERBB2, PTEN, KRAS, NRAS, PIK3CA, MLH1, BAD",0.503070351926785,0.246416941107093,FALSE +"H358","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.23559,0.718,0.808,981,0.873,"MAPK13, F11R, LYN, MAPK10, MAPK9, MET, TJP1",0.0925886392254138,0.0589857562944303,FALSE +"H358","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.38844,1.16,0.272,1584,0.501,"EREG, AREG, PIK3R3, PIK3CD, MAPK10, RPS6KB2, MAPK9, ERBB2, CAMK2D, KRAS, NRAS, RPS6KB1, MAP2K4, CAMK2G, PIK3CA, ERBB3, PRKCG, ERBB4, BAD",0.565431095965801,0.300162274132754,FALSE +"H358","Input","KEGG_ETHER_LIPID_METABOLISM",0.48928,1.52,0.0742,974,0.852,"LPCAT2, LPCAT4, PLPP2, LPCAT1, PLA2G4A, PLA2G12A",1.12959609472097,0.0695604052332999,FALSE +"H358","Input","KEGG_FATTY_ACID_METABOLISM",-0.40144,-1.25,0.186,7739,0.346,"ECI2, ALDH7A1, ACADS, ACAT2, ACSL5, EHHADH, GCDH, ALDH2, ACADSB, ACAA2",0.730487055782084,0.460923901207223,FALSE +"H358","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.44116,1.37,0.135,1293,0.624,"MAPK13, RAC2, PIK3R3, LYN, PIK3CD, MAPK10, MAPK9, PLA2G4A, RAC3, PLA2G12A, KRAS, NRAS, PRKCD, MAP2K4, PIK3CA",0.869666231504994,0.204815410317576,FALSE +"H358","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.27061,0.848,0.629,685,0.756,"RAC2, PIK3R3, HCK, LYN, PLPP2, PIK3CD, RPS6KB2, PLA2G4A, MARCKSL1, SCIN",0.201349354554731,0.121478204498793,FALSE +"H358","Input","KEGG_FOCAL_ADHESION",0.27438,0.865,0.6,663,0.772,"RAC2, ITGB6, LAMC2, TNC, ITGB4, CAV1, ITGA3, CAV2, LAMB3, LAMA5, THBS1, PIK3R3, CTNNB1, PIK3CD, MAPK10, MAPK9, CAPN2, CCND1, ERBB2, PTEN",0.221848749616356,0.112382699664264,FALSE +"H358","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.56123,-1.72,0.0325,7518,0.196,"ALPG, QDPR, SPR, GGH",1.48811663902113,0.707743928643524,TRUE +"H358","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.26697,-0.815,0.662,6206,0.803,"PMM2, PFKP, TPI1, GMPPA, PFKM, MPI, PMM1, PFKL, MTMR6, AKR1B10, PHPT1, AKR1B1",0.1791420105603,0.095284454721319,FALSE +"H358","Input","KEGG_GALACTOSE_METABOLISM",-0.27798,-0.863,0.6,5799,0.767,"GALT, GLA, GANC, PFKP, UGP2, GLB1, GCK, PFKM, PFKL, GALK1, AKR1B1",0.221848749616356,0.115204636051019,FALSE +"H358","Input","KEGG_GAP_JUNCTION",-0.29563,-0.891,0.541,6333,0.722,"PRKACB, GUCY1B1, GNA11, TUBA1C, TUBA1B, TUBB1, GNAI1, RAF1, TUBB, TUBA3C, SRC, GNAQ, TUBB2A, MAPK7, MAPK1, ITPR3, GRM5, TUBB6, GUCY1A1, TUBB2B, MAP2K2, GJA1, ITPR1, TUBB4A, ITPR2, SOS1",0.266802734893431,0.141462802430361,FALSE +"H358","Input","KEGG_GLIOMA",0.28779,0.881,0.578,1461,0.751,"PIK3R3, PIK3CD, RB1, CCND1, PTEN, CAMK2D, KRAS, NRAS, IGF1R, CAMK2G, PIK3CA, PRKCG",0.238072161579471,0.124360062995832,FALSE +"H358","Input","KEGG_GLUTATHIONE_METABOLISM",-0.53235,-1.61,0.0543,7465,0.217,"GPX4, GGT7, GSTP1, GSTA4, GGCT, IDH1, GGT1, GPX2, GSTO1, RRM2B, MGST3, ANPEP, IDH2, GPX6, GPX7, GSTK1, TXNDC12, GSTM3, GSTM1, GSTM2, GSTM4",1.26520017041115,0.66354026615147,FALSE +"H358","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.33778,-1.05,0.355,8822,0.514,"PLPP1, GK, AKR1B1, AKR1A1, ALDH2, AGPAT3",0.449771646944906,0.289036881004724,FALSE +"H358","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.32143,1.01,0.382,554,0.637,"LPCAT2, LPCAT4, MBOAT2, PLPP2, LPCAT1, CHKB, MBOAT1, PLA2G4A, GPAT3",0.417936637088291,0.19586056766465,FALSE +"H358","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.45088,-1.37,0.13,8322,0.322,"AGXT, PSPH, GCAT, SARDH, PSAT1, MAOB, GLDC",0.886056647693163,0.492144128304169,FALSE +"H358","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.23074,0.693,0.828,1568,0.898,"ALDH1A3, ADH4, ADH7, PKM, PGM2, PKLR, ENO1, ENO3, ALDH3A2, ALDH3B1",0.0819696632151199,0.0467236633326956,FALSE +"H358","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.56934,-1.75,0.0208,7600,0.199,"XYLT2, CHST13, CSGALNACT2, CHST12, B4GALT7, XYLT1, CHST3, CHST11",1.68193666503724,0.701146923590293,TRUE +"H358","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.35211,-1.08,0.34,7600,0.505,"XYLT2, NDST1, EXTL2, B4GALT7, XYLT1",0.468521082957745,0.296708621881339,FALSE +"H358","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.43658,-1.35,0.137,8711,0.318,"B4GALT4, ST3GAL1",0.863279432843593,0.497572880015567,FALSE +"H358","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.36731,-1.15,0.252,8073,0.433,"HGSNAT, GUSB, IDUA, GNS, HEXB, ARSB",0.598599459218456,0.363512103646635,FALSE +"H358","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.68557,-2.13,0.00573,8603,0.156,"NAGA, HEXB, ST3GAL1",2.24184537803261,0.806875401645538,TRUE +"H358","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.47613,-1.48,0.0696,8711,0.271,"B4GALT4, FUT4, ST3GAL6",1.15739076038944,0.567030709125594,FALSE +"H358","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.37327,1.17,0.249,1236,0.499,"PIGG, PIGW, PIGK, PIGS, PIGT",0.603800652904264,0.30189945437661,FALSE +"H358","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.43064,-1.34,0.118,8167,0.312,"GRHPR, ACO2, PGP",0.928117992693875,0.505845405981557,FALSE +"H358","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.28301,0.858,0.584,1216,0.761,"MAPK13, MAPK10, MAPK9, PLA2G4A, PLCB1, PTK2B, PLA2G12A, CAMK2D, KRAS, NRAS, PRKCD, MAP2K4, CAMK2G",0.233587152887601,0.118615343229427,FALSE +"H358","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.33321,-1.04,0.347,8928,0.522,"WNT16, WNT11",0.459670525209126,0.282329496997738,FALSE +"H358","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.41356,-1.27,0.187,7735,0.337,"KIT, ITGA1, CSF2RA, ANPEP, ITGB3, CD7, ITGA5, ITGA4, IL6",0.728158393463501,0.472370099128661,FALSE +"H358","Input","KEGG_HISTIDINE_METABOLISM",-0.34815,-1.07,0.32,7312,0.505,"TRMT11, AOC1, ALDH7A1, HNMT, LCMT1, MAOB, DDC, ALDH2",0.494850021680094,0.296708621881339,FALSE +"H358","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.41437,1.25,0.19,2231,0.505,"POLD3, RAD54B, POLD1, RAD51C, EME1, RAD54L, POLD2, RPA3, BLM, RPA2, TOP3A, RPA1",0.721246399047171,0.296708621881339,FALSE +"H358","Input","KEGG_HUNTINGTONS_DISEASE",-0.33169,-1.02,0.389,6162,0.539,"ATP5PO, NDUFS7, NDUFB6, TFAM, ATP5PF, NDUFV1, AP2M1, COX6A1, NDUFS2, CLTB, NDUFB10, CREB5, ATP5F1E, NDUFV3, DNAL1, NDUFA8, NDUFS4, ATP5PB, GRIN1, NDUFA10, VDAC2, ATP5F1D, AP2S1, CREB3L2, GNAQ, COX7A2L, NDUFA7, NDUFB2, COX6B1, VDAC1, ATP5F1B, CASP9, POLR2I, DCTN4, NDUFS6, NDUFV2, ATP5PD, NDUFS3, IFT57, DNAH2, GRM5, TGM2, ATP5F1C, NDUFS8, UQCRB, CYCS, ATP5F1A, APAF1, NDUFA5, HIP1, UQCRC1, DCTN1, BAX, AP2A2, ATP5MC2, UQCRFS1, SOD1, DCTN2, ITPR1, UQCRC2, SOD2, TP53",0.410050398674292,0.268411234813261,FALSE +"H358","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.34436,-1.07,0.324,7794,0.505,"PRKAB2, ITGA1, CACNA2D2, ACE, TGFB1, SGCB, TGFB3, ITGB8, TPM2, ITGB3, ACTG1, SGCD, ITGA5, ITGA7, DES, ITGA4, IL6",0.489454989793388,0.296708621881339,FALSE +"H358","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.27896,-0.854,0.614,6782,0.766,"PIP4K2A, PIP4K2B, PIK3C2A, SYNJ1, PIK3C2B, OCRL, PIP5K1C, PLCG1, PIK3C3, INPP5K, PIKFYVE, PLCG2, ITPKA, IMPA1, MINPP1, ITPK1, PIK3CB, ITPKB",0.211831628858832,0.115771230367396,FALSE +"H358","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.19998,-0.616,0.943,6207,0.97,"RPTOR, TSC2, PRKAA1, PRKAR2A, MAPK8, PRKACB, PRKAA2, FLOT2, AKT3, PRKAG2, RAF1, PRKAR1A, GCK, CBLB, GSK3B, PIK3R2, RAPGEF1, MAPK1, RHEB, SHC1, PRKAG1, PPP1R3D, TSC1, PRKAR1B, GYS1, INPP5D, PRKAR2B, PRKAB2, IRS2, INPP5K, PIK3R1, PRKCI, PPP1R3A, CRKL, INSR, MAP2K2, PIK3CB, PDE3B, CRK, SORBS1, PCK2, FOXO1, SOS1",0.0254883072626717,0.0132282657337552,FALSE +"H358","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.68318,-2.11,0.00382,8209,0.131,"ICOSLG, TGFB1, ITGA4, IL6",2.41793663708829,0.882728704344236,TRUE +"H358","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.27411,-0.847,0.642,7649,0.77,"TYK2, IFNGR1, LEPR, STAT5A, PIK3R1, CSF2RA, OSM, PIM1, STAT2, STAM, PIK3CB, PIAS2, SOS1, IFNAR2, IL6",0.192464971931147,0.113509274827518,FALSE +"H358","Input","KEGG_LEISHMANIA_INFECTION",0.37631,1.18,0.225,52,0.539,"MAPK13, ITGB2, PTGS2",0.647817481888638,0.268411234813261,FALSE +"H358","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.45698,1.41,0.133,409,0.725,"CLDN7, MAPK13, RAC2, ITGB2, CLDN4, F11R, CTNNA1, CTNND1, PIK3R3, CLDN3, CTNNB1, CTNNA2, PIK3CD",0.876148359032914,0.139661993429006,FALSE +"H358","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.57323,-1.71,0.0452,6689,0.183,"ECHS1, ALDH1B1, ALDH7A1, EHHADH, ALDH2",1.34486156518862,0.737548910269571,TRUE +"H358","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.40407,1.24,0.182,974,0.503,"PLA2G4A, PLA2G12A",0.739928612014925,0.298432014944073,FALSE +"H358","Input","KEGG_LONG_TERM_DEPRESSION",-0.22166,-0.679,0.894,8896,0.933,"ITPR1, ITPR2, PPP1R17",0.0486624812040823,0.0301183562535,FALSE +"H358","Input","KEGG_LONG_TERM_POTENTIATION",0.2607,0.822,0.67,1461,0.794,"PPP3CA, PLCB1, PPP3R2, CAMK2D, RPS6KA1, KRAS, NRAS, PPP3R1, CAMK2G, EP300, CHP1, CREBBP, PRKCG",0.173925197299174,0.100179497572904,FALSE +"H358","Input","KEGG_LYSINE_DEGRADATION",-0.34335,-1.05,0.379,7412,0.514,"PLOD1, AASS, OGDH, ALDH7A1, PLOD3, OGDHL, ACAT2, SETDB1, EHHADH, GCDH, ALDH2, TMLHE",0.421360790031928,0.289036881004724,FALSE +"H358","Input","KEGG_LYSOSOME",-0.42291,-1.3,0.164,6514,0.316,"AP3D1, AP3S1, LAMP2, ENTPD4, GLB1, NEU1, ASAH1, AP3B1, PSAP, AP3M2, LAMP1, CLN5, ARSA, HEXA, GBA, ATP6V0D2, ATP6V0A2, CTSH, CTSA, AP3M1, ACP5, CTSK, CTSO, LIPA, GGA1, TPP1, ATP6V1H, NAPSA, ATP6V0A1, SUMF1, GGA2, CTSZ, HGSNAT, GUSB, AP3S2, IDUA, ACP2, DNASE2, AP1M1, NAGPA, PLA2G15, NAGA, GNS, PPT2, GM2A, IGF2R, CLN3, SMPD1, MAN2B1, HEXB, CD63, ARSB, SLC17A5",0.785156151952302,0.500312917381596,FALSE +"H358","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.24673,-0.782,0.716,7883,0.846,"FLNC, MAP4K3, TAB1, MAPK8IP3, CACNA2D2, FGFR3, CRKL, MAP3K11, DUSP3, MAP3K7, FGFR4, MAPK12, TGFB1, RELB, ARRB2, MAPK11, TGFB3, MAP2K2, NFKB2, FGFR1, PPP3CC, TAOK3, CRK, DUSP9, RASA2, SOS1, TP53, FGF13, FGF2, STK4, MAPT",0.145086977692144,0.0726296369609765,FALSE +"H358","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.6123,-1.91,0.0131,7830,0.183,"IAPP, HNF1B, PDX1, HNF1A, HNF4A, MNX1, PAX6, NEUROD1",1.88272870434424,0.737548910269571,TRUE +"H358","Input","KEGG_MELANOGENESIS",-0.24352,-0.75,0.795,6685,0.894,"RAF1, CREB3L2, GNAQ, GSK3B, FZD7, MAPK1, MITF, ASIP, FZD1, TYRP1, DVL3, DVL2, KIT, TCF7L2, MAP2K2, LEF1, DCT, WNT16, WNT11",0.0996328713435297,0.0486624812040823,FALSE +"H358","Input","KEGG_MELANOMA",-0.30676,-0.954,0.48,8517,0.639,"MAP2K2, CDKN2A, FGFR1, PIK3CB, HGF, TP53, FGF13, FGF2",0.318758762624413,0.1944991418416,FALSE +"H358","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.53266,-1.68,0.038,8249,0.179,"GSTO1, CYP3A5, MGST3, GSTK1, AKR1C3, AKR1C1, GSTM3, GSTM1, GSTM2, GSTM4, AKR1C2",1.42021640338319,0.747146969020107,TRUE +"H358","Input","KEGG_MISMATCH_REPAIR",0.69746,2.14,0.00851,2231,0.219,"PCNA, POLD3, MSH6, RFC3, POLD1, LIG1, MSH2, RFC4, RFC5, RFC2, POLD2, MLH1, RFC1, MSH3, RPA3, RPA2, RPA1",2.07007043991541,0.659555885159882,TRUE +"H358","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.29271,0.89,0.523,1293,0.746,"CAB39, PIK3R3, PIK3CD, RPS6KB2, HIF1A, RPS6KA1, RPS6KB1, PIK3CA",0.281498311132726,0.127261172527331,FALSE +"H358","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.43174,1.34,0.132,1461,0.523,"RAC2, ITGB2, LCK, RAET1L, ULBP2, PIK3R3, TNFRSF10A, PIK3CD, PPP3CA, RAC3, PTK2B, PPP3R2, KRAS, NRAS, PPP3R1, PIK3CA, FAS, CHP1, PRKCG",0.87942606879415,0.281498311132726,FALSE +"H358","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.41402,-1.3,0.151,6579,0.316,"GRIN1, TSPO, PARD3, GRM5, LEPR, P2RX4, TACR1, PRSS3, PLG",0.821023052706831,0.500312917381596,FALSE +"H358","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.24965,0.78,0.729,1612,0.802,"MAPK13, IRS1, RPS6KA4, PIK3R3, PIK3CD, MAPK10, MAPK9, ARHGDIB, CAMK2D, RPS6KA1, KRAS, NRAS, PRKCD, CAMK2G, YWHAZ, KIDINS220, PIK3CA, BAD, FRS2, CSK, SORT1",0.137272471682025,0.0958256317158365,FALSE +"H358","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.53954,-1.66,0.0455,8626,0.186,"ENPP1, NNMT, BST1, NMNAT3, QPRT",1.34198860334289,0.730487055782084,TRUE +"H358","Input","KEGG_NITROGEN_METABOLISM",-0.63599,-1.94,0.00566,8024,0.212,"CA1, ASNS, CA8, GLS, GLS2, CPS1, CA12, CA2",2.24718356881173,0.673664139071249,TRUE +"H358","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.23521,-0.723,0.839,7691,0.908,"TRAF6, TAB1, CASP1, MAP3K7, MAPK12, MAPK11, PYCARD, IL6",0.0762380391712997,0.0419141514789149,FALSE +"H358","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.43034,1.35,0.143,851,0.591,"FEN1, XRCC5, XRCC6",0.844663962534938,0.228412519118745,FALSE +"H358","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.26132,0.797,0.661,1584,0.782,"PIK3R3, RXRA, PIK3CD, RB1, CCND1, ERBB2, RXRG, RXRB, KRAS, NRAS, PIK3CA, PRKCG, BAD",0.17979854051436,0.106793246940152,FALSE +"H358","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.45266,1.37,0.129,1722,0.624,"NOTCH3, JAG2, JAG1, NCOR2, RBPJ, CTBP1, EP300, CREBBP, KAT2A, DVL1",0.889410289700751,0.204815410317576,FALSE +"H358","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.53415,1.64,0.0451,2231,0.662,"PCNA, POLD3, RFC3, POLD1, LIG1, RFC4, RFC5, POLE3, RFC2, CUL4A, POLD2, RFC1, DDB2, RBX1, RPA3, POLE2, RPA2, CUL4B, RPA1",1.34582345812204,0.1791420105603,FALSE +"H358","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.2729,-0.844,0.601,7776,0.766,"ST6GAL1, MGAT4B, DPAGT1, MGAT3, MGAT1, MAN1A1, ALG11, MGAT5",0.22112552799726,0.115771230367396,FALSE +"H358","Input","KEGG_OLFACTORY_TRANSDUCTION",0.35112,1.07,0.334,1818,0.567,"CAMK2D, CAMK2G, CNGB1",0.476253533188435,0.246416941107093,FALSE +"H358","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.36155,-1.11,0.289,6496,0.474,"MTHFD2L, MTR, TYMS, GART, ALDH1L1, MTHFR",0.539102157243452,0.324221658325915,FALSE +"H358","Input","KEGG_OOCYTE_MEIOSIS",0.38869,1.17,0.254,1993,0.499,"CDC20, AR, STAG3, BUB1, CCNB1, PLK1, PPP3CA, CCNB2, MAD2L1, AURKA, PPP3R2, BTRC, CAMK2D, CDK1, RPS6KA1, IGF1R, CDK2, PPP2CB, PPP3R1, CAMK2G, YWHAZ, PPP2R5C, CHP1, PPP2R5E, SMC3, ESPL1, PPP3CB, SMC1A, RBX1, YWHAQ, SMC1B, SGO1",0.595166283380062,0.30189945437661,FALSE +"H358","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.41248,-1.28,0.162,6428,0.332,"MAN2C1, GLB1, NEU1, HEXA, GBA, MAN2B1, HEXB",0.790484985457369,0.478861916295964,FALSE +"H358","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.43471,-1.31,0.13,6162,0.326,"ATP5PO, NDUFS7, NDUFB6, ATP5PF, NDUFV1, COX6A1, NDUFS2, NDUFB10, ATP6V1C1, ATP5F1E, NDUFV3, NDUFA8, NDUFS4, ATP5PB, NDUFA10, ATP5F1D, COX7A2L, NDUFA7, NDUFB2, ATP6V1F, COX6B1, ATP5F1B, NDUFS6, ATP6V1D, ATP6V0D2, NDUFV2, ATP5PD, ATP6V0A2, NDUFS3, ATP5F1C, NDUFS8, UQCRB, ATP6V1C2, ATP5ME, ATP6V1A, ATP5F1A, ATP6V1H, ATP6V1B2, ATP6V1B1, NDUFA5, ATP6V0A1, ATP6V1E1, UQCRC1, COX15, ATP5MC2, UQCRFS1, COX11, UQCRC2, ATP6V1G1",0.886056647693163,0.486782399932061,FALSE +"H358","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.58837,1.84,0.0271,634,0.375,"GALNT13, GALNT7, GALNT3, GALNT10, GALNT6, GALNT15",1.56703070912559,0.425968732272281,FALSE +"H358","Input","KEGG_P53_SIGNALING_PATHWAY",0.39489,1.22,0.189,1324,0.489,"SERPINB5, THBS1, CHEK1, STEAP3, CCNB1, CCND1, CCNB2, EI24, RRM2, PTEN, CDK1, CDK2, GTSE1, FAS",0.723538195826756,0.31069114087638,FALSE +"H358","Input","KEGG_PANCREATIC_CANCER",0.36209,1.1,0.303,1088,0.54,"RAC2, PIK3R3, PIK3CD, MAPK10, RB1, MAPK9, RALB, CCND1, ERBB2, SMAD3, RAC3, TGFB2, KRAS",0.518557371497695,0.267606240177031,FALSE +"H358","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.6089,-1.89,0.0133,6783,0.16,"PANK3, DPYD, PPCS, PANK4, ENPP1, BCAT1",1.87614835903291,0.795880017344075,TRUE +"H358","Input","KEGG_PARKINSONS_DISEASE",-0.4253,-1.33,0.155,6104,0.317,"SLC18A1, ATP5PO, NDUFS7, NDUFB6, ATP5PF, NDUFV1, COX6A1, NDUFS2, NDUFB10, ATP5F1E, NDUFV3, NDUFA8, NDUFS4, ATP5PB, NDUFA10, VDAC2, ATP5F1D, COX7A2L, NDUFA7, NDUFB2, COX6B1, VDAC1, ATP5F1B, CASP9, NDUFS6, NDUFV2, ATP5PD, NDUFS3, HTRA2, ATP5F1C, NDUFS8, UQCRB, CYCS, ATP5F1A, APAF1, NDUFA5, UQCRC1, UBE2L3, UBA7, UBE2G1, ATP5MC2, UQCRFS1, UBE2J1, UQCRC2, SNCA, UCHL1",0.809668301829709,0.498940737782249,FALSE +"H358","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.21291,-0.669,0.895,6266,0.937,"ARPC5L, ARPC4, TUBA1C, ARHGEF2, TUBA1B, TUBB1, NCK1, ARPC2, TUBB, TUBA3C, ARPC1B, ARPC5, TUBB2A, CLDN1, WASL, ROCK1, TUBB6, HCLS1, FYN, NCK2, TUBB2B, TUBB4A, ACTG1",0.048176964684088,0.0282604091122217,FALSE +"H358","Input","KEGG_PATHWAYS_IN_CANCER",0.29168,0.904,0.538,1132,0.758,"RAC2, LAMC2, PTGS2, SLC2A1, ITGA3, CDH1, LAMB3, AR, LAMA5, CTNNA1, MAX, PIK3R3, PIAS1, CTNNB1, CTNNA2, RXRA, PIK3CD, MAPK10, RB1, MAPK9, RUNX1, RALB, CCND1, MSH6, ETS1, ERBB2, RXRG, PTEN, SMAD3, MSH2, SKP2, RAC3, CTBP1, HIF1A, MECOM, MET, CKS1B, TGFB2, RXRB, KRAS, NRAS, IGF1R, ITGA6, CDK2, FZD6",0.269217724333611,0.120330794367946,FALSE +"H358","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.50067,-1.54,0.0741,7692,0.242,"RPE, CRYL1, GUSB, XYLB, AKR1B1",1.13018179202067,0.616184634019569,FALSE +"H358","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.34873,-1.05,0.358,6220,0.514,"PRPS1, PRPS1L1, TALDO1, PFKP, PFKM, PFKL, RPE, GPI, DERA, H6PD, PGLS",0.446116973356126,0.289036881004724,FALSE +"H358","Input","KEGG_PEROXISOME",-0.44496,-1.37,0.12,7272,0.322,"HSD17B4, DHRS4, DAO, PXMP4, PRDX1, MLYCD, ECI2, IDH1, PEX5, PECR, DECR2, CAT, CRAT, ABCD1, HACL1, AGXT, IDH2, ACSL5, EHHADH, GSTK1, SOD1, FAR2, SOD2, NUDT19, PHYH, ECH1",0.920818753952375,0.492144128304169,FALSE +"H358","Input","KEGG_PHENYLALANINE_METABOLISM",-0.35979,-1.11,0.296,8710,0.474,"GOT1, MAOB, DDC",0.528708288941061,0.324221658325915,FALSE +"H358","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.27855,-0.857,0.597,6782,0.77,"PIP4K2A, PIP4K2B, PIK3C2A, PIK3R2, SYNJ1, PIK3C2B, OCRL, PIP5K1C, ITPR3, PLCG1, INPP5D, PIK3C3, INPP5K, PIKFYVE, PLCG2, PIK3R1, ITPKA, IMPA1, ITPK1, PIK3CB, ITPKB, ITPR1, ITPR2",0.224025668870631,0.113509274827518,FALSE +"H358","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.42796,-1.3,0.159,7931,0.316,"CPOX, GUSB, EARS2, HMOX1, COX15, BLVRA, UROS, BLVRB, FTH1",0.798602875679548,0.500312917381596,FALSE +"H358","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.4506,-1.41,0.103,7615,0.314,"FABP5, APOA1, OLR1, SCD, ILK, SLC27A6, ACSL5, EHHADH, HMGCS2, SLC27A1, APOA2, SORBS1, PCK2, GK, FABP1, CYP27A1, FABP7, FABP3",0.987162775294828,0.503070351926785,FALSE +"H358","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.59486,-1.85,0.0129,6247,0.173,"ACOX2, AMACR, HSD17B4, AKR1D1, CYP27A1",1.88941028970075,0.761953896871205,TRUE +"H358","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.41778,1.31,0.152,583,0.525,"LCK, UNG",0.818156412055227,0.279840696594043,FALSE +"H358","Input","KEGG_PRION_DISEASES",-0.57953,-1.78,0.0405,8236,0.188,"FYN, BAX, C5, MAP2K2, SOD1, C9, IL6",1.39254497678533,0.72584215073632,TRUE +"H358","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.45866,1.39,0.108,1098,0.715,"MAPK13, FZR1, CCNA2, PIK3R3, BUB1, PIK3CD, MAPK10, CCNB1, PLK1, MAPK9, CCNB2, MAD2L1, CDK1, RPS6KA1, KRAS, IGF1R, CDK2",0.96657624451305,0.145693958198919,FALSE +"H358","Input","KEGG_PROPANOATE_METABOLISM",-0.57885,-1.78,0.0213,6689,0.188,"ECHS1, ALDH1B1, PCCA, ACADM, MLYCD, ALDH7A1, ACAT2, ACSS1, ACSS2, ACSS3, PCCB, EHHADH, MCEE, ALDH2, ABAT",1.67162039656126,0.72584215073632,TRUE +"H358","Input","KEGG_PROSTATE_CANCER",0.26226,0.813,0.694,1404,0.787,"AR, PIK3R3, CTNNB1, PIK3CD, RB1, CCND1, ERBB2, PTEN, KRAS, NRAS, IGF1R, CDK2, PIK3CA, EP300, CREBBP",0.158640529545145,0.104025267640935,FALSE +"H358","Input","KEGG_PROTEASOME",0.17383,0.532,0.987,1486,0.99,"PSME1, PSME2, PSMB8, PSME3",0.00568284733036327,0.00436480540245009,FALSE +"H358","Input","KEGG_PROTEIN_EXPORT",-0.17313,-0.542,0.99,8519,0.988,"SEC11C, IMMP1L",0.00436480540245009,0.00524305541237188,FALSE +"H358","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.54988,-1.69,0.0378,8513,0.189,"GLS, GLS2, ATP1B3, PCK2, AQP1, CA2",1.42250820016277,0.723538195826756,TRUE +"H358","Input","KEGG_PURINE_METABOLISM",0.26219,0.818,0.695,982,0.79,"PDE5A, NT5E, POLA1, PRIM1, PRIM2, PKM, POLD3, NME7, POLD1, RRM2, NME3, POLA2, POLE3, POLR3C, PDE4D, POLR3F, ENTPD6, POLR3B, DCK, POLR3G",0.158015195409886,0.102372908709559,FALSE +"H358","Input","KEGG_PYRIMIDINE_METABOLISM",0.39848,1.22,0.214,1339,0.489,"CDA, NT5E, POLA1, PRIM1, DUT, PRIM2, POLD3, NME7, POLD1, RRM2, UCK2, NME3, POLA2, POLE3, POLR3C, POLR3F, ENTPD6, POLR3B, DCK, POLR3G, TK1, TK2, PNP, UCK1, POLD2",0.669586226650809,0.31069114087638,FALSE +"H358","Input","KEGG_PYRUVATE_METABOLISM",-0.45103,-1.37,0.129,7460,0.322,"ACYP1, PC, ALDH7A1, GRHPR, ACAT2, ACSS1, ACSS2, PCK2, AKR1B1, ALDH2, HAGH",0.889410289700751,0.492144128304169,FALSE +"H358","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.21013,-0.641,0.936,7837,0.958,"ITGA1, GSN, PIKFYVE, PIK3R1, DOCK1, FGFR3, ENAH, CRKL, VCL, FGFR4, MYH10, ARHGEF6, FGD1, MAP2K2, FN1, FGFR1, ITGB8, PIK3CB, CRK, ITGB3, ACTG1, SOS1, IQGAP2, ITGA5, ITGA7, FGF13, FGF2, ITGA4",0.0287241512618947,0.0186344909214556,FALSE +"H358","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.57295,-1.73,0.037,6267,0.201,"PRKAA1, PIK3R4, PRKAA2, ATG3, ATG4A, ULK1, PIK3C3, ATG12, ATG4B, GABARAPL1, ULK3",1.431798275933,0.696803942579511,TRUE +"H358","Input","KEGG_RENAL_CELL_CARCINOMA",0.25478,0.8,0.68,1980,0.788,"SLC2A1, PIK3R3, PIK3CD, ETS1, HIF1A, MET, TGFB2, KRAS, NRAS, PIK3CA, EP300, CREBBP, ELOC, CDC42, RBX1, ELOB, JUN",0.167491087293764,0.103473782510445,FALSE +"H358","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.53302,-1.68,0.0432,7507,0.179,"CTSA, ENPEP, ACE, AGT, ANPEP",1.36451625318509,0.747146969020107,TRUE +"H358","Input","KEGG_RETINOL_METABOLISM",-0.38819,-1.19,0.227,8270,0.393,"CYP3A5, RDH10, ALDH1A2, ALDH1A1",0.643974142806877,0.405607449624573,FALSE +"H358","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.43072,-1.34,0.148,7532,0.312,"ACP5, MTMR6, ACP2, ENPP1, PHPT1",0.829738284605043,0.505845405981557,FALSE +"H358","Input","KEGG_RIBOSOME",0.27159,0.857,0.609,3836,0.751,"RPS4Y1, RPL22, FAU, RPS23, RPS25, RPS3A, RPL23A, RPL8, RPS11, RPS8, RPS29, RPL7, RPL34, RPS5, RPL28, RPL7A, RPS15, RPS13, RPL10, RPL18, RPS27L, RPL26, RPS17, RPS9, RPL37A, RPL36A, RPL36AL, RPS2, RPS6, RPL36, RPL15, RPL21, RPS18, RPL17, RPL10A, RPL5, RPL27, RPL19, RPL18A, RPL11, RPL14, RPL32, RPL13A, RPS16, MRPL13, RPL13",0.215382707367125,0.124360062995832,FALSE +"H358","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.37634,1.17,0.258,952,0.499,"MAPK13, DDX3Y, ISG15, MAPK10, MAPK9, DDX58, TKFC",0.58838029403677,0.30189945437661,FALSE +"H358","Input","KEGG_RNA_DEGRADATION",0.31524,0.977,0.432,2938,0.688,"XRN2, PAPOLA, EXOSC5, EXOSC6, DCPS, PAPOLG, EXOSC9, EXOSC8, EXOSC7, ENO1, DIS3, ENO3, EXOSC3, EXOSC10, EXOSC2, CNOT6, CNOT6L, MTREX, DDX6, DCP1A, LSM6, LSM8, LSM1, EXOSC1, LSM2",0.364516253185088,0.162411561764489,FALSE +"H358","Input","KEGG_RNA_POLYMERASE",0.41045,1.26,0.184,3305,0.525,"POLR3C, POLR3F, POLR3B, POLR3G, POLR3A, POLR2K, POLR1B, POLR3H, POLR1A, POLR3D, POLR1E, POLR1C, POLR1D, POLR3K, POLR2B",0.735182176990464,0.279840696594043,FALSE +"H358","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.23458,-0.728,0.822,6033,0.91,"SEPHS2, AHCY, MAT2B, METTL2B, TRMT11, GGT7, GGT1, LCMT1, PAPSS2",0.0851281824599496,0.0409586076789064,FALSE +"H358","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.41269,1.28,0.183,1098,0.532,"LAMC2, PTGS2, ITGA3, LAMB3, LAMA5, MAX, PIK3R3, PIAS1, RXRA, PIK3CD, RB1, CCND1, RXRG, PTEN, SKP2, CKS1B, RXRB, ITGA6, CDK2",0.737548910269571,0.274088367704952,FALSE +"H358","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.23245,-0.702,0.829,6730,0.921,"SNAP25, USE1, GOSR2, VAMP7, VAMP5, SNAP29, STX7, BET1, YKT6, STX2",0.0814454694497265,0.0357403698031511,FALSE +"H358","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.24352,-0.742,0.792,6538,0.897,"SGPP1, GLB1, NEU1, ASAH1, ARSA, UGCG, GBA, KDSR, SMPD2, SMPD3, PLPP1, SMPD1",0.101274818410506,0.0472075569559079,FALSE +"H358","Input","KEGG_SPLICEOSOME",0.40037,1.23,0.194,3679,0.504,"DHX8, DHX15, ALYREF, DDX42, SNRPB2, DHX16, CTNNBL1, DDX5, SNRPA1, HSPA2, PRPF3, AQR, CDC5L, SF3B1, NCBP1, DHX38, DDX46, U2AF2, SRSF5, CRNKL1, PUF60, SF3B3, RBMX, SRSF8, DDX39B, CWC15, SNRPE, BCAS2, PRPF4, PHF5A, SART1, HSPA1A, PLRG1, SNRPD1, SNRPD2, XAB2, SNRNP200, LSM6, EIF4A3, PRPF19, THOC1, SF3B4, RBM25, LSM8, USP39, SF3B6, SRSF9, LSM2, SF3A3, TRA2A, HNRNPM, HNRNPA1, SNW1, PRPF40A, SNRPB, ISY1, SF3B5, PRPF38A, SNRPA, U2AF1, PRPF8, LSM3, SF3A1, PPIL1, SNRPD3, SRSF6, HNRNPK, HSPA6, SRSF2, PRPF31, THOC2, PRPF6, SNRNP70",0.712198270069774,0.297569463554475,FALSE +"H358","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.22692,-0.692,0.875,7549,0.925,"GYS1, GPI, GUSB, ENPP1, SI, UXS1",0.0579919469776868,0.0338582672609674,FALSE +"H358","Input","KEGG_STEROID_BIOSYNTHESIS",-0.49274,-1.53,0.0696,7665,0.242,"CEL, LIPA, SOAT2, FDFT1, SQLE",1.15739076038944,0.616184634019569,FALSE +"H358","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.72859,-2.27,0.00183,8270,0.0934,"CYP3A5, AKR1D1, CYP21A2, HSD3B1, AKR1C3, HSD17B2, AKR1C1, HSD11B2, AKR1C2",2.73754891026957,1.02965312376991,TRUE +"H358","Input","KEGG_SULFUR_METABOLISM",-0.7871,-2.45,0,7602,0.0357,"SULT1A3, CHST13, SUOX, PAPSS2, CHST12, CHST11, SULT1A1",Inf,1.44733178388781,TRUE +"H358","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.40922,-1.26,0.17,6645,0.341,"ELANE, CD40, TRIM21, C3, C5, C4A, C9",0.769551078621726,0.467245621007502,FALSE +"H358","Input","KEGG_TASTE_TRANSDUCTION",0.47947,1.48,0.0845,1100,0.685,"SCNN1B, CACNA1A",1.07314329105031,0.164309428507574,FALSE +"H358","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.50306,-1.58,0.0466,7194,0.224,"PDSS2, GGPS1, HMGCR, HMGCS1, ACAT2, HMGCS2, IDI1",1.33161408331,0.649751981665837,TRUE +"H358","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.2907,0.908,0.529,1404,0.763,"SMURF1, THBS1, ID1, RPS6KB2, SMAD3, RBL1, ACVR1, TGFB2, PPP2CB, RPS6KB1, SMURF2, EP300, CREBBP",0.276544327964814,0.11747546204512,FALSE +"H358","Input","KEGG_THYROID_CANCER",0.37034,1.14,0.242,1089,0.497,"CDH1, CTNNB1, RXRA, CCND1, RXRG, RXRB, KRAS, NRAS",0.616184634019569,0.303643611266668,FALSE +"H358","Input","KEGG_TIGHT_JUNCTION",0.4082,1.26,0.182,1464,0.525,"CLDN7, PRKCH, CLDN4, F11R, CTNNA1, CLDN3, CTNNB1, CTNNA2, LLGL2, PATJ, CRB3, CASK, PTEN, MYH9, MYH11, RAB13, CSNK2A1, CSNK2A2, TJP1, MAGI3, CGN, KRAS, NRAS, EPB41L1, PPP2CB, TJP2, PRKCD, OCLN, PRKCZ, MYL12A, PRKCG, CSNK2B",0.739928612014925,0.279840696594043,FALSE +"H358","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.26182,-0.829,0.664,6324,0.786,"MAPK8, RELA, IKBKG, AKT3, IRF3, TRAF3, CHUK, TBK1, CD40, PIK3R2, RIPK1, MAPK1, SPP1, IRAK4, CTSK, TRAF6, LBP, TAB1, PIK3R1, MAP3K7, MAPK12, MAPK11, TOLLIP, MAP2K2, PIK3CB, IFNAR2, IL6",0.177831920631982,0.104577453960592,FALSE +"H358","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.55285,-1.71,0.0336,7375,0.183,"AOC1, KYNU, OGDH, ALDH7A1, CAT, OGDHL, ACAT2, EHHADH, MAOB, DDC, GCDH, ALDH2",1.47366072261016,0.737548910269571,TRUE +"H358","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.48852,1.51,0.0756,1342,0.773,"IRS1, PIK3R3, PIK3CD, MAPK10, PKM, MAPK9, ABCC8, CACNA1A, PRKCD, PIK3CA, PRKCZ, PKLR",1.12147820449879,0.111820506081675,FALSE +"H358","Input","KEGG_TYROSINE_METABOLISM",0.32926,1.01,0.418,410,0.637,"ALDH1A3, ADH4, ADH7, MAOA",0.378823718224965,0.19586056766465,FALSE +"H358","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.27725,0.862,0.603,1362,0.765,"MAPK13, LCK, PIK3R3, PIK3CD, MAPK9, PPP3CA, PPP3R2, KRAS, NRAS, PPP3R1, TEC, PIK3CA, CHP1",0.219682687859849,0.116338564846382,FALSE +"H358","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29576,0.908,0.531,2737,0.763,"FZR1, CDC20, UBE2C, SMURF1, PIAS1, UBE2E2, FANCL, UBE2S, UBE3A, WWP2, SKP2, CUL4A, UBE2W, BTRC, CUL3, UBR5, UBE2O, SMURF2, ITCH, UBA3, DDB2, ELOC, PIAS3, BRCA1, RBX1, ELOB, UBE4A, CUL4B, PPIL2, MAP3K1, RNF7, UBE2A, CUL5, MID1, UBA6, COP1, PML, DDB1, UBE2D2, UBE2K, UBE4B, PRPF19",0.274905478918531,0.11747546204512,FALSE +"H358","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.61649,-1.9,0.0136,8770,0.171,"BCAT1",1.86646109162978,0.767003889607846,TRUE +"H358","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.51404,-1.6,0.0475,7819,0.216,"ALDH7A1, ACADS, HMGCS1, BCKDHB, ACAT2, PCCB, EHHADH, MCEE, HMGCS2, BCAT1, ALDH2, ACADSB, ABAT, ACAA2",1.32330639037513,0.665546248849069,TRUE +"H358","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.24199,0.738,0.785,1186,0.852,"PRKCH, PPP1R14A, PLA2G4A, PLCB1, MYL6, MYH11, MYLK, PLA2G12A, PRKCD",0.105130343254747,0.0695604052332999,FALSE +"H358","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.29197,-0.899,0.551,5911,0.715,"DYNC1I2, DYNC2LI1, RAB5C, DYNC2H1, PRKACB, CREB5, RAB5B, CREB3L2, DYNC1LI1, DCTN4, DCTN6, DCTN5, DYNLL1, DCTN1, DCTN2",0.258848401148215,0.145693958198919,FALSE +"H358","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.43288,1.34,0.143,1829,0.523,"MAPK13, RAC2, PTGS2, PIK3R3, PIK3CD, PLA2G4A, PPP3CA, RAC3, PPP3R2, PLA2G12A, KRAS, NRAS, PPP3R1, PIK3CA, CHP1, PRKCG, BAD, PPP3CB, CDC42",0.844663962534938,0.281498311132726,FALSE +"H358","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.43673,-1.32,0.166,7218,0.321,"ATP6V1D, ATP6V0D2, ATP6V0A2, PDIA4, ATP6V1C2, PLCG1, ATP6V1A, ATP6V1H, ATP6V1B2, ATP6V1B1, ATP6V0A1, ATP6V1E1, PLCG2, KDELR1, ACTG1, ATP6V1G1",0.779891911959945,0.493494967595128,FALSE +"H358","Input","KEGG_VIRAL_MYOCARDITIS",0.41889,1.34,0.125,984,0.523,"RAC2, ITGB2, CAV1, CCND1, MYH9, RAC3, MYH11, DAG1, CD55",0.903089986991944,0.281498311132726,FALSE +"H358","Input","KEGG_WNT_SIGNALING_PATHWAY",0.43014,1.35,0.139,1464,0.591,"RAC2, NKD2, CTNNB1, CHD8, FOSL1, MAPK10, VANGL1, MAPK9, CCND1, PPP3CA, SMAD3, RAC3, CTBP1, DKK1, TBL1X, PLCB1, CSNK1E, DAAM1, TBL1XR1, PPP3R2, BTRC, CSNK2A1, CSNK2A2, CAMK2D, PPP2CB, PPP3R1, FZD6, CAMK2G, PPP2R5C, EP300, CHP1, PPP2R5E, CREBBP, PRKCG, CSNK2B",0.856985199745905,0.228412519118745,FALSE +"A549","Input","KEGG_ABC_TRANSPORTERS",0.66076,1.96,0.00926,292,0.395,"ABCC2, ABCA1, ABCG2, ABCC8, ABCC3, ABCC1, ABCC4",2.03338901331807,0.40340290437354,FALSE +"A549","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.38087,-1.09,0.329,6338,0.708,"FLT3, TCF7L1, RELA, IKBKB, MTOR, STAT5A, TCF7L2, SOS1, MAP2K1, PIK3CD, MAP2K2, BRAF, EIF4EBP1, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PML, PIK3CB, NFKB1, AKT1, MAPK1, RUNX1, MAPK3",0.482804102050026,0.149966742310231,FALSE +"A549","Input","KEGG_ADHERENS_JUNCTION",-0.25827,-0.742,0.79,8178,0.913,"AFDN, WAS, WASF2, CTNNA1, PTPN6, FARP2, CDH1, MAPK1, ERBB2, ACTG1, MAPK3, NECTIN1, BAIAP2, NECTIN4, RAC2",0.102372908709559,0.039529222465701,FALSE +"A549","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.28132,-0.803,0.717,6358,0.848,"ACACB, RELA, ADIPOR1, IKBKB, MTOR, TRADD, MAPK9, PRKAA1, RXRA, RXRB, NFKBIE, MAPK10, CPT1A, NFKBIA, NFKB1, AKT1, ACSL1, ACSL5, STK11",0.1444808443322,0.0716041477432862,FALSE +"A549","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.40005,-1.14,0.267,8462,0.671,"ASNS, GFPT1, ADSL, ASL, GPT2, IL4I1, ABAT, ASS1, GLUL, DDO",0.573488738635425,0.173277479831008,FALSE +"A549","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.54035,-1.55,0.0669,7844,0.886,"PIK3R1, ATP1B1, KRAS, SCNN1G, PIK3CA, ATP1A1, ATP1A4, ATP1A3, PIK3CB, ATP1B3, MAPK1, MAPK3, PDPK1, HSD11B2, SCNN1A",1.17457388223218,0.0525662781129492,FALSE +"A549","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.51331,-1.44,0.098,9161,0.67,"PLA2G12A, PLA2G2A",1.00877392430751,0.173925197299174,FALSE +"A549","Input","KEGG_ALZHEIMERS_DISEASE",-0.21812,-0.598,0.954,8450,0.998,"PLCB1, FADD, COX7C, CACNA1F, CALM2, CASP3, MAPK1, MAPT, PLCB3, SNCA, CAPN1, MAPK3, MME, LPL",0.0204516252959049,0.000869458712628891,FALSE +"A549","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.29233,-0.843,0.61,5457,0.806,"NARS2, FARSB, IARS2, SEPSECS, RARS2, SARS2, AARS2, DARS2, VARS2, WARS2, LARS2, FARSA, PARS2, TARS2, MARS2, CARS2",0.214670164989233,0.0936649581949093,FALSE +"A549","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.50313,-1.38,0.127,7876,0.602,"GALK2, NANS, CYB5R1, GNPNAT1, GMPPB, GALE, PGM3, PGM1, GMPPA, GFPT1, HEXB, HK2, FPGT, RENBP, GCK, AMDHD2, UAP1, MPI, PGM2, HK1, GMDS",0.896196279044043,0.220403508742175,FALSE +"A549","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.37017,1.09,0.308,1061,0.621,"NEFH, PRPH, PRPH2, GPX1, NEFL, BAD, MAP2K6, BCL2L1, PPP3R1",0.511449283499556,0.20690839982342,FALSE +"A549","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.3026,-0.869,0.595,9089,0.781,"PSME2, PSME1, IFI30, CD74, B2M",0.22548303427145,0.1073489661227,FALSE +"A549","Input","KEGG_APOPTOSIS",-0.21555,-0.608,0.952,7315,1,"PIK3CD, CASP10, RIPK1, MYD88, ENDOD1, PRKAR1B, CASP7, PIK3R1, PIK3CA, NFKBIA, IRAK4, FADD, PRKAR2B, PIK3CB, CASP3, NFKB1, AKT1, IL1RAP, CAPN1, BCL2, IL1A",0.0213630516155257,0,FALSE +"A549","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.35969,-1.02,0.382,9161,0.716,"PLA2G12A, PTGS1, GPX6, GPX7, PLA2G2A, ALOX5",0.417936637088291,0.145086977692144,FALSE +"A549","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.34839,-0.983,0.432,8468,0.716,"LAP3, ACY1, MAOB, ASL, PRODH, PRODH2, MAOA, CKB, ARG1, ASS1, CKMT2, GLUL, ARG2, CKMT1A",0.364516253185088,0.145086977692144,FALSE +"A549","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.55562,1.67,0.0402,720,0.348,"DES, GJA1, ITGA3, CDH2, CACNA2D2, CACNA2D1, SGCD, ITGA5, ITGB1, ITGB5, ITGAV, ITGB3, ACTN1, ACTN4, ATP2A2",1.39577394691553,0.458420756053419,FALSE +"A549","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.57996,1.68,0.0334,1107,0.382,"ALDH2, ALDH1B1, UGDH, ALDH3A2",1.47625353318844,0.417936637088291,FALSE +"A549","Input","KEGG_AXON_GUIDANCE",-0.36138,-1.04,0.364,7702,0.697,"RAC1, PAK2, ABLIM3, EPHB3, GSK3B, RASA1, DPYSL5, KRAS, NRAS, ROCK1, ARHGEF12, PAK3, NCK2, NTN1, CXCR4, PAK1, EPHA4, ROBO2, LIMK2, MAPK1, PLXNA3, SLIT1, SLIT3, EPHA1, MAPK3, PLXNA2, SLIT2, PAK5, PAK6, UNC5B, NFATC2, EFNB2, RAC2",0.438898616350944,0.156767221901991,FALSE +"A549","Input","KEGG_BASAL_CELL_CARCINOMA",0.3861,1.13,0.266,907,0.663,"FZD2, FZD7, SUFU",0.575118363368933,0.178486471595227,FALSE +"A549","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.32275,0.938,0.508,852,0.763,"GTF2E1, STON1, GTF2E2",0.294136287716081,0.11747546204512,FALSE +"A549","Input","KEGG_BASE_EXCISION_REPAIR",0.38329,1.12,0.297,2845,0.64,"NEIL2, POLL, POLE3, POLE4, NTHL1, XRCC1, POLD4, POLD3, POLD1, POLB, MPG, POLD2, TDG, MBD4",0.527243550682788,0.193820026016113,FALSE +"A549","Input","KEGG_BETA_ALANINE_METABOLISM",0.3743,1.09,0.332,1107,0.621,"ALDH2, ALDH1B1, ALDH3A2",0.478861916295964,0.20690839982342,FALSE +"A549","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.59604,1.75,0.021,943,0.5,"SCD5, HACD1, ACOT2, ELOVL5, FADS1, FADS2, PECR",1.67778070526608,0.301029995663981,FALSE +"A549","Input","KEGG_BLADDER_CANCER",-0.31342,-0.883,0.573,7636,0.802,"MAP2K2, BRAF, RASSF1, RAF1, THBS1, TYMP, KRAS, NRAS, E2F1, CDH1, MAPK1, RPS6KA5, CDKN2A, ERBB2, MAPK3",0.24184537803261,0.0958256317158365,FALSE +"A549","Input","KEGG_BUTANOATE_METABOLISM",-0.37138,-1.07,0.343,8830,0.709,"ACAT2, AACS, ABAT, HMGCS2, OXCT1, BDH1",0.464705879957229,0.149353764816933,FALSE +"A549","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.52515,-1.5,0.0742,7558,0.959,"NFKBIE, MAP2K2, RAC1, VAV2, GSK3B, RAF1, PIK3R1, KRAS, NRAS, VAV1, BTK, PIK3CA, PLCG2, PTPN6, BCL10, NFKBIA, VAV3, CD79B, PIK3CB, NFKB1, AKT1, MAPK1, INPP5D, MAPK3, FOS, SYK, CARD11, NFATC2, DAPP1, RAC2",1.12959609472097,0.0181813928293364,FALSE +"A549","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.38447,1.12,0.301,1261,0.64,"CD38, MYLK, BST1, PLCB4, PRKCG, ITPR1, ATP2B1, PRKCB, PLCD3, ATP2A2, TACR1, ADCY3, ADCY8, PPP3R1, SPHK2, GNAQ, PHKA1, PRKACA, PRKCA",0.521433504406157,0.193820026016113,FALSE +"A549","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.42487,1.26,0.175,803,0.607,"TPM2, TPM1, CACNA2D2, CACNA2D1, ATP2A2, TPM4",0.756961951313706,0.216811308924742,FALSE +"A549","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.40097,-1.15,0.273,9212,0.755,"ICOSLG, SDC3, NCAM1, NECTIN1, ITGAL, SDC2, ITGB8, CLDN11, CDH15, CDH3, CLDN3, CLDN7, CLDN4, CLDN18",0.563837352959244,0.122053048370812,FALSE +"A549","Input","KEGG_CELL_CYCLE",0.20691,0.603,0.964,2255,0.977,"CDKN1A, TGFB2, MDM2, CCNB3, ANAPC11, ANAPC10, SMAD3, SMAD2, ATR, YWHAQ, PRKDC, STAG1, CCND1, ATM, CDC26, CDK6, CDC25B, TFDP2, ORC5, ANAPC4, BUB3, CDK4, MAD1L1, CDKN1B, CDC27",0.0159229660971692,0.0101054362812269,FALSE +"A549","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.33049,-0.943,0.486,7315,0.758,"PIK3CD, GNAI2, PREX1, CCR4, PTK2B, RAP1B, CCL13, GRK6, BRAF, RAC1, VAV2, GSK3B, RAF1, GRK5, PIK3R1, CCL15, KRAS, NRAS, VAV1, PIK3CA, ROCK1, PLCB2, WAS, NFKBIA, VAV3, PRKCD, PLCB1, CXCR4, CRKL, PAK1, PIK3CB, GNG10, ARRB1, NFKB1, AKT1, MAPK1, GNG2, GRK2, PLCB3, GNG5, PRKCZ, MAPK3, STAT2, RAC2",0.313363730737707,0.120330794367946,FALSE +"A549","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.27277,-0.796,0.689,7636,0.852,"MAP2K2, BRAF, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, HDAC1, CBLB, NFKBIA, E2F1, CRKL, PIK3CB, NFKB1, AKT1, MAPK1, BCR, CDKN2A, RUNX1, MAPK3, CBL, MECOM",0.161780778092374,0.0695604052332999,FALSE +"A549","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.62733,-1.75,0.023,9641,0.615,"PER3",1.63827216398241,0.211124884224583,FALSE +"A549","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.17608,-0.512,0.995,6120,1,"PCK2, CS, ACO1, MDH2, SUCLA2, OGDHL, IDH1, DLD, OGDH, ACO2, MDH1, DLAT, IDH2",0.00217691925427455,0,FALSE +"A549","Input","KEGG_COLORECTAL_CANCER",-0.30952,-0.872,0.576,7566,0.785,"MAPK10, BRAF, RAC1, GSK3B, RAF1, CTNNB1, PIK3R1, KRAS, PIK3CA, PIK3CB, CASP3, AKT1, MAPK1, BIRC5, MAPK3, FOS, BCL2, RAC2",0.239577516576788,0.105130343254747,FALSE +"A549","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.55397,1.64,0.0539,1069,0.346,"FGA, C1S, THBD, C9, SERPINE1, PLAUR, SERPIND1, TFPI, PLAU, MASP1, CD59, C1R, F3",1.26841123481326,0.460923901207223,FALSE +"A549","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.32168,-0.936,0.488,8482,0.762,"CBS, ENOPH1, IL4I1, MTAP, CTH",0.311580177997289,0.1180450286604,FALSE +"A549","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33143,0.985,0.419,1199,0.712,"TGFB2, CXCL5, EDAR, OSMR, TNFRSF10D, TGFBR2, TNFRSF12A, TGFBR1, TNFRSF10C, KITLG, CD70, TNFRSF10A, ACVR1, IL18, TNFRSF10B, ACVR1B, IL6ST, CD40",0.377785977033705,0.147520006363144,FALSE +"A549","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.32311,-0.912,0.526,9447,0.772,"DDX58, RIPK3, CASP1",0.279014255846261,0.112382699664264,FALSE +"A549","Input","KEGG_DILATED_CARDIOMYOPATHY",0.615,1.84,0.0136,911,0.456,"TPM2, DES, TPM1, ITGA3, TGFB2, CACNA2D2, CACNA2D1, SGCD, ITGA5, ITGB1, ITGB5, ITGAV, ITGB3, ATP2A2, TPM4, ADCY3, ADCY8, ITGA1",1.86646109162978,0.341035157335565,FALSE +"A549","Input","KEGG_DNA_REPLICATION",0.24818,0.715,0.822,2823,0.926,"POLE3, POLE4, RNASEH1, POLA2, POLD4, POLD3, SSBP1, POLD1, POLA1, PRIM2, POLD2, PRIM1, RNASEH2A",0.0851281824599496,0.0333890133180656,FALSE +"A549","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.49682,-1.42,0.111,7112,0.676,"SOS1, MAP2K1, ETV6, KRAS, NOTCH2, MAPK1, MAPK3",0.954677021213343,0.170053304058364,FALSE +"A549","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.50471,-1.45,0.0819,8431,0.862,"GSTA2, UGT2B17, MAOB, FMO2, FMO4, FMO5, ALDH1A3, MAOA, GSTM3, ADH4, ADH7, ADH1C, GSTM4",1.08671609823958,0.0644927341752872,FALSE +"A549","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.36841,-1.05,0.367,5976,0.701,"UGT2B11, UGT2B4, UCK2, HPRT1, GUSB, NAT1, ITPA, UPP1, UCKL1, XDH, TYMP, CES1, CES2, TPMT, UGT2B17",0.435333935747911,0.154281982033341,FALSE +"A549","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.46992,1.37,0.112,402,0.517,"COL5A2, COL4A1, COL5A1, COL4A2, ITGA3, ITGA5, ITGB1, ITGB5, LAMB1, CD44, ITGAV, FN1, ITGB3, SPP1",0.950781977329818,0.286509456906058,FALSE +"A549","Input","KEGG_ENDOCYTOSIS",-0.23839,-0.678,0.899,8085,0.996,"PRKCI, PARD6A, ARFGAP2, DNM2, RAB22A, CBLB, RNF41, RAB11B, DNAJC6, CXCR4, VPS37B, CHMP4A, CHMP4B, SH3GLB1, ARRB1, VPS4B, ARAP1, ACAP2, GRK2, CHMP4C, ERBB4, PRKCZ, FGFR2, SH3GL2, LDLR, CBL, ARAP2, RAB11FIP4, ERBB3, PSD4, EPN3",0.0462403082667712,0.00174066157630127,FALSE +"A549","Input","KEGG_ENDOMETRIAL_CANCER",-0.36937,-1.08,0.314,7636,0.702,"MAP2K2, BRAF, GSK3B, RAF1, CTNNB1, PIK3R1, CTNNA2, KRAS, NRAS, PIK3CA, CTNNA1, PIK3CB, CDH1, AKT1, MAPK1, ERBB2, MAPK3, PDPK1",0.503070351926785,0.153662887870195,FALSE +"A549","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.48793,-1.39,0.124,7392,0.64,"TCIRG1, ATP6V0C, ATP6V0D1, MAPK10, RAC1, ATP6V0A1, MAPK14, PLCG2, ATP6AP1, ATP6V1C1, F11R, ATP6V1E1, NFKBIA, ATP6V1B2, ATP6V1F, PAK1, ATP6V1A, CASP3, NFKB1, ATP6V1H, ATP6V1D, ATP6V1B1, ATP6V1G1, MAPK12",0.906578314837765,0.193820026016113,FALSE +"A549","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.28073,-0.783,0.71,7566,0.866,"MAPK10, AREG, MAP2K2, BRAF, EIF4EBP1, PAK2, GSK3B, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PAK3, PLCG2, NCK2, CBLB, CRKL, PAK1, PIK3CB, AKT1, MAPK1, ERBB2, ERBB4, MAP2K7, MAPK3, CBL, PAK5, PAK6, ERBB3",0.148741651280925,0.0624821079826534,FALSE +"A549","Input","KEGG_ETHER_LIPID_METABOLISM",0.37443,1.07,0.352,1996,0.607,"PLPP1, PLA2G4A, PLPP3, CHPT1, PLD2, PLPP2, AGPS",0.453457336521869,0.216811308924742,FALSE +"A549","Input","KEGG_FATTY_ACID_METABOLISM",-0.46214,-1.31,0.147,8234,0.647,"ALDH9A1, CPT1A, ACADM, ACAT2, ACSL1, GCDH, CPT2, ADH4, ADH7, ACSL5, ADH1C",0.832682665251824,0.1890957193313,FALSE +"A549","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.49999,-1.41,0.111,7090,0.662,"MAPK9, SOS1, MAP2K1, PIK3CD, GAB2, MAP2K3, MAPK10, MAP2K2, RAC1, VAV2, RAF1, PIK3R1, KRAS, NRAS, VAV1, BTK, PIK3CA, MAPK14, PLCG2, VAV3, PRKCD, PIK3CB, AKT1, MAPK1, INPP5D, MAP2K7, PLA2G12A, MAPK3, PDPK1, SYK, PLA2G2A, MAPK12, RAC2",0.954677021213343,0.1791420105603,FALSE +"A549","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.29827,-0.872,0.59,7702,0.785,"RAC1, VAV2, RAF1, PIK3R1, VAV1, PTPRC, PIK3CA, WAS, WASF2, DNM2, PLCG2, VAV3, PRKCD, SPHK1, CRKL, PAK1, PIK3CB, GSN, LIMK2, AKT1, MAPK1, INPP5D, AMPH, MARCKSL1, MAPK3, SYK, SCIN, RAC2",0.229147988357856,0.105130343254747,FALSE +"A549","Input","KEGG_FOCAL_ADHESION",0.36156,1.08,0.321,991,0.622,"COL5A2, COL4A1, COL5A1, COL4A2, CAV2, MYLK, ITGA3, ITGA5, ITGB1, ITGB5, AKT3, FLNB, LAMB1, PRKCG, ITGAV, FN1, SRC, ITGB3, SPP1, ZYX, FLNA, ACTN1, ACTN4, CAV1, PPP1R12A, PRKCB, PARVA, LAMA5, ILK, BAD, ITGA1, IGF1R, PARVB",0.493494967595128,0.206209615309181,FALSE +"A549","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.77497,-2.17,0,9658,0.286,"ALPI, ALPP, ALPG",Inf,0.543633966870957,FALSE +"A549","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.46754,-1.34,0.143,8420,0.632,"GMPPA, ALDOB, FBP2, HK2, FPGT, FBP1, PFKFB2, PFKFB4, MPI, PFKL, HK1, GMDS, ALDOC",0.844663962534938,0.199282921717615,FALSE +"A549","Input","KEGG_GALACTOSE_METABOLISM",-0.35035,-1,0.396,7649,0.736,"PFKM, GALK2, GALE, PGM1, HK2, GCK, PGM2, PFKL, HK1",0.402304814074488,0.133122185662501,FALSE +"A549","Input","KEGG_GAP_JUNCTION",0.4356,1.29,0.15,1261,0.607,"GJA1, PLCB4, PRKCG, TUBB2B, LPAR1, SRC, TJP1, GNAI1, ITPR1, TUBA4A, PRKCB, ADCY3, ADCY8, GNAQ, PRKACA, PRKCA",0.823908740944319,0.216811308924742,FALSE +"A549","Input","KEGG_GLIOMA",0.25313,0.747,0.805,1564,0.932,"CDKN1A, AKT3, PRKCG, MDM2, PRKCB, IGF1R, PRKCA, PIK3R2, CCND1",0.0942041196321315,0.0305840876460186,FALSE +"A549","Input","KEGG_GLUTATHIONE_METABOLISM",-0.34838,-0.987,0.436,8014,0.741,"GGT7, GSTM1, OPLAH, GSTA2, RRM2, LAP3, GPX3, IDH2, GGCT, GSTM3, GPX6, GPX7, GSTM4",0.360513510731414,0.130181792020672,FALSE +"A549","Input","KEGG_GLYCEROLIPID_METABOLISM",0.28138,0.821,0.673,491,0.847,"AKR1B1, ALDH2, ALDH1B1, PLPP1, PLPP3",0.171984935776023,0.0721165896692931,FALSE +"A549","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.27319,-0.778,0.744,8081,0.866,"PEMT, ETNK1, PISD, MBOAT1, DGKH, DGKQ, PLA2G15, PLA2G12A, CHKB, LYPLA2, CDS1, PLA2G2A, PCYT2",0.128427064454121,0.0624821079826534,FALSE +"A549","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.31233,0.923,0.496,564,0.778,"GLDC, PIPOX, GAMT",0.304518323509803,0.109020403010311,FALSE +"A549","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.40878,-1.14,0.253,8234,0.671,"ALDH9A1, ACSS1, PGM1, DLAT, ALDOB, FBP2, HK2, FBP1, GCK, ALDH1A3, ADH4, ADH7, PGM2, PFKL, ACSS2, HK1, ADH1C, ALDOC",0.596879478824182,0.173277479831008,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.47409,-1.38,0.106,9330,0.602,"CSGALNACT1, UST",0.97469413473523,0.220403508742175,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.2526,0.746,0.786,2787,0.918,"NDST1, B3GALT6, EXTL2, B3GAT3",0.104577453960592,0.0371573187987575,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.39167,-1.12,0.285,8587,0.671,"B4GALT3, ST3GAL2, ST3GAL1",0.54515513999149,0.173277479831008,FALSE +"A549","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.25406,-0.725,0.82,7713,0.933,"IDS, GNS, SGSH, HEXB, HPSE",0.0861861476162833,0.0301183562535,FALSE +"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.50834,-1.44,0.118,8748,0.67,"HEXB, ST3GAL2, ST3GAL1",0.928117992693875,0.173925197299174,FALSE +"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.6881,-1.97,0.00705,8748,0.262,"HEXB, NAGA, ST3GAL2, ST3GAL1",2.1518108830086,0.581698708680255,FALSE +"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.49259,-1.44,0.0748,9433,0.67,"FUT3, ST3GAL4, B3GNT3",1.12609840213554,0.173925197299174,FALSE +"A549","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.51744,1.51,0.0679,2983,0.455,"PIGB, PIGX, PIGG, PIGQ, PIGH, PIGO, PIGW, PIGN",1.1681302257195,0.341988603342888,FALSE +"A549","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.51685,-1.49,0.0665,7465,0.895,"PGP, GLYCTK, MTHFD2L, ACO2, MDH1, HYI, AFMID",1.1771783546969,0.048176964684088,FALSE +"A549","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.31728,-0.899,0.581,7470,0.779,"PTK2B, MAP2K3, MAPK10, MAP3K4, MAP2K2, RAF1, KRAS, NRAS, CALML3, PLCB2, MAPK14, PRKCD, PLCB1, MAP3K3, CACNA1F, CALM2, MAPK1, PLCB3, MAP2K7, PLA2G12A, MAPK3, PLA2G2A, MMP14, MAPK12",0.235823867609669,0.108462542327436,FALSE +"A549","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.20165,-0.586,0.976,7757,0.996,"GSK3B, WNT5B, CSNK1A1",0.0105501823333082,0.00174066157630127,FALSE +"A549","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.50287,1.47,0.0819,911,0.445,"CD38, ITGA3, ITGA5, CD44, ITGB3, KITLG, CD59, ITGA1",1.08671609823958,0.351639989019068,FALSE +"A549","Input","KEGG_HISTIDINE_METABOLISM",0.3877,1.16,0.241,316,0.646,"ALDH3A1, ALDH3B1, ALDH2, ALDH1B1",0.617982957425132,0.189767482004916,FALSE +"A549","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.47319,1.4,0.105,2666,0.497,"RAD54L, BRCA2, EME1, MUS81, NBN, BLM, RAD54B, POLD4, POLD3, SSBP1, POLD1, TOP3A, RAD51C, POLD2",0.978810700930062,0.303643611266668,FALSE +"A549","Input","KEGG_HUNTINGTONS_DISEASE",0.21392,0.632,0.955,3502,0.97,"TGM2, PLCB4, GPX1, ITPR1, POLR2D, AP2A2, GNAQ, HIP1, NDUFA2, BBC3, CLTA, SDHC, POLR2L, AP2M1, SDHA, POLR2I, AP2S1, SDHB, ATP5PF, SDHD, NDUFS6, POLR2E, SLC25A6, NDUFV3, POLR2G, UQCRFS1, CLTC, NDUFB2, NDUFA10, NDUFV1, NDUFA7, NDUFA5, SLC25A4, NDUFS1, AP2A1, BAX, COX6B1, DNAL1, DCTN1, NDUFB9, NDUFS5, NDUFB7, COX7A2L, VDAC1, AP2B1, NDUFS4, DCTN2, NDUFB3, HAP1",0.0199966284162537,0.0132282657337552,FALSE +"A549","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.58381,1.71,0.0423,911,0.471,"TPM2, DES, TPM1, ITGA3, TGFB2, CACNA2D2, CACNA2D1, SGCD, ITGA5, ITGB1, ITGB5, ITGAV, ITGB3, ATP2A2, TPM4, ITGA1",1.37365963262496,0.326979092871104,FALSE +"A549","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.3942,-1.14,0.251,7200,0.671,"PIP5K1A, PIK3CD, TPI1, INPPL1, ISYNA1, ALDH6A1, PIK3C3, PIK3CA, PLCB2, PLCG2, ITPKA, PLCB1, ITPK1, PIK3CB, PIK3C2B, PI4KB, SYNJ1, INPP5B, IMPA2, PLCB3",0.600326278518962,0.173277479831008,FALSE +"A549","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.32829,-0.955,0.455,7090,0.754,"MAPK9, SOS1, MAP2K1, PRKAA1, PTPN1, PIK3CD, SORBS1, MKNK1, RAPGEF1, MAPK10, PHKG2, MAP2K2, BRAF, EIF4EBP1, PRKAR1B, GSK3B, RAF1, PIK3R1, KRAS, NRAS, PRKCI, PIK3CA, CALML3, CBLB, GYS1, PRKAR2B, CRKL, PIK3CB, CALM2, AKT1, MAPK1, FBP2, HK2, FOXO1, FBP1, GCK, INPP5D, PRKCZ, PPP1R3D, MAPK3, PDPK1, CBL, HK1",0.341988603342888,0.122628654130226,FALSE +"A549","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.39955,-1.14,0.279,6996,0.671,"IL15RA, IL6, CXCR4, TNFSF13B, ICOSLG",0.554395796726402,0.173277479831008,FALSE +"A549","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.34543,-0.983,0.425,7571,0.716,"IL6, SPRED2, PIK3R1, LIFR, PIK3CA, CBLB, PTPN6, IFNAR1, STAT6, PIK3CB, SPRY4, AKT1, IRF9, STAT2, EPO, CBL, PRLR, SPRY1",0.371611069949688,0.145086977692144,FALSE +"A549","Input","KEGG_LEISHMANIA_INFECTION",-0.40968,-1.16,0.25,8229,0.794,"MAPK14, PTPN6, NFKBIA, IRAK4, NFKB1, MAPK1, MARCKSL1, MAPK3, FOS, IL1A, MAPK12",0.602059991327962,0.100179497572904,FALSE +"A549","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.47542,-1.39,0.115,7702,0.64,"RAC1, VAV2, ITGB2, CTNNB1, PIK3R1, CTNNA2, VAV1, OCLN, PIK3CA, ROCK1, AFDN, MAPK14, PLCG2, F11R, CTNNA1, RASSF5, VAV3, CXCR4, PIK3CB, ICAM1, ACTG1, ITGAL, CLDN11, CLDN3, MAPK12, CLDN7, RAC2, CLDN4, CLDN18",0.939302159646388,0.193820026016113,FALSE +"A549","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.52094,1.52,0.0716,1107,0.485,"ALDH2, ALDH1B1, ALDH3A2",1.14508697769214,0.314258261397736,FALSE +"A549","Input","KEGG_LONG_TERM_DEPRESSION",0.27085,0.789,0.738,1261,0.882,"PLCB4, PRKCG, PLA2G4A, GNAI1, ITPR1, PRKCB, GNA13, IGF1R, GNAQ, PRKCA",0.131943638176958,0.0545314148681803,FALSE +"A549","Input","KEGG_LONG_TERM_POTENTIATION",0.28298,0.844,0.637,1261,0.846,"PLCB4, PRKCG, ITPR1, PPP1R12A, PRKCB, ADCY8, PPP3R1, GNAQ, PRKACA, PRKCA",0.19586056766465,0.0726296369609765,FALSE +"A549","Input","KEGG_LYSINE_DEGRADATION",0.36706,1.1,0.312,316,0.64,"PLOD2, PIPOX, ALDH2, ALDH1B1",0.505845405981557,0.193820026016113,FALSE +"A549","Input","KEGG_LYSOSOME",-0.40736,-1.15,0.249,7182,0.755,"MAN2B1, AP3M2, NEU1, PPT2, SUMF1, TCIRG1, ATP6V0C, ATP6V0D1, SMPD1, IGF2R, IDS, GNS, ATP6V0A1, AP1S1, SGSH, SCARB2, GGA2, NPC2, ATP6AP1, CTSH, SLC11A2, CTSK, CTSO, LIPA, PPT1, HEXB, SLC17A5, DNASE2, SORT1, GGA1, ATP6V1H, FUCA1, AP1B1, PLA2G15, CLN5, NAGA, GM2A, LAMP1, CTSC, AP1M2, CTSE, MANBA, LAMP3, LAPTM5",0.603800652904264,0.122053048370812,FALSE +"A549","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.23817,-0.672,0.889,8501,0.993,"MAPKAPK2, MAP3K5, CRKL, MAP3K3, PAK1, CACNA1F, DUSP10, CASP3, ARRB1, RPS6KA4, NFKB1, AKT1, MAPK1, RPS6KA5, MAPT, LAMTOR3, STMN1, MAPKAPK3, MAP4K2, MAP2K7, FGFR2, PLA2G12A, MAPK3, FOS, RPS6KA1, NFATC2, PLA2G2A, IL1A, MECOM, MAPK12, RAC2",0.0510982390297863,0.00305075150461883,FALSE +"A549","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.3633,-1.03,0.37,8892,0.706,"HES1, GCK, IAPP",0.431798275933005,0.151195298948196,FALSE +"A549","Input","KEGG_MELANOGENESIS",0.33522,0.988,0.393,1261,0.724,"FZD2, PLCB4, PRKCG, GNAI1, PRKCB, FZD7, KITLG, ADCY3, ADCY8, MITF, GNAQ, PRKACA, PRKCA",0.405607449624573,0.140261433802853,FALSE +"A549","Input","KEGG_MELANOMA",0.43539,1.27,0.188,977,0.617,"FGF13, FGF2, CDKN1A, AKT3, MDM2, BAD, MITF, IGF1R",0.72584215073632,0.209714835966758,FALSE +"A549","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.41251,1.21,0.202,318,0.622,"AKR1C2, ALDH3A1, AKR1C1, ALDH3B1, AKR1C3, CYP2S1",0.694648630553376,0.206209615309181,FALSE +"A549","Input","KEGG_MISMATCH_REPAIR",-0.21391,-0.615,0.959,2094,1,"PMS2, POLD4, POLD3, SSBP1, MSH6, POLD1, POLD2, MSH3, MSH2, MLH1, RPA1, PCNA, RPA2, RFC1, RPA3, RFC2, RFC5, RFC4, RFC3, LIG1, EXO1",0.0181813928293364,0,FALSE +"A549","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.38951,-1.11,0.29,7644,0.678,"BRAF, EIF4EBP1, PIK3R1, PIK3CA, CAB39L, PIK3CB, AKT1, MAPK1, CAB39, MAPK3, PDPK1, RPS6KA1, STK11",0.537602002101044,0.168770306132937,FALSE +"A549","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.43024,-1.24,0.189,7636,0.665,"MAP2K2, BRAF, RAC1, VAV2, RAF1, ITGB2, PIK3R1, MICA, KRAS, NRAS, VAV1, PIK3CA, PLCG2, PTPN6, IFNAR1, VAV3, RAET1L, ULBP2, PAK1, PIK3CB, ICAM1, CASP3, MAPK1, SH3BP2, MAPK3, LCK, ITGAL, SYK, NFATC2, RAC2",0.723538195826756,0.177178354696895,FALSE +"A549","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.29375,-0.825,0.648,9000,0.814,"PRSS2, HCRTR1, TSPO, PRLR",0.188424994129407,0.0893755951107988,FALSE +"A549","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.44965,-1.29,0.178,7498,0.668,"RAP1B, RAPGEF1, NFKBIE, MAPK10, MAP2K2, BRAF, RAC1, GSK3B, RAF1, ARHGDIA, PIK3R1, KRAS, NRAS, FRS2, PIK3CA, CALML3, MAPK14, PLCG2, NFKBIA, PRKCD, IRAK4, MAPKAPK2, MAP3K5, CRKL, MAP3K3, NGFR, PIK3CB, CALM2, RPS6KA4, NFKB1, AKT1, MAPK1, RPS6KA5, SORT1, MAP2K7, MAPK3, PDPK1, ARHGDIB, RPS6KA1, BCL2, MAPK12",0.749579997691106,0.175223537524454,FALSE +"A549","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.45827,1.35,0.136,163,0.521,"NNMT, CD38, BST1",0.866461091629782,0.283162276700476,FALSE +"A549","Input","KEGG_NITROGEN_METABOLISM",0.40232,1.18,0.229,667,0.631,"CPS1, GLUD2, CA12, CA8, GLS, GLS2",0.640164517660112,0.199970640755866,FALSE +"A549","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.59547,-1.71,0.0215,8767,0.529,"NFKB1, MAPK1, MAPK3, CASP1, MAPK12, CASP5",1.66756154008439,0.276544327964814,FALSE +"A549","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.40184,1.19,0.227,2300,0.637,"PRKDC, POLL, DCLRE1C, LIG4",0.643974142806877,0.19586056766465,FALSE +"A549","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.32196,-0.916,0.512,7112,0.773,"SOS1, MAP2K1, PIK3CD, RXRA, RXRB, MAP2K2, BRAF, RASSF1, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PLCG2, RASSF5, E2F1, PIK3CB, AKT1, MAPK1, CDKN2A, ERBB2, MAPK3, PDPK1",0.290730039024169,0.111820506081675,FALSE +"A549","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.35897,1.05,0.368,734,0.633,"JAG1, NUMBL, JAG2, NCOR2, DTX2",0.434152181326482,0.198596289982645,FALSE +"A549","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.32436,0.948,0.475,3620,0.759,"DDB2, ERCC8, XPC, CETN2, POLE3, ERCC1, POLE4, POLD4, GTF2H1, POLD3, GTF2H5, POLD1, CCNH, POLD2, GTF2H2, ERCC2, MNAT1, CDK7, GTF2H3, CUL4B, GTF2H4, XPA, RPA1, POLE2, ERCC3",0.323306390375133,0.11975822410452,FALSE +"A549","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.22791,-0.66,0.916,7192,0.999,"MGAT1, ALG9, STT3A, ALG6, ALG11, MGAT3, MGAT5, B4GALT3, MGAT4B, MAN1A1, ST6GAL1",0.0381045263321496,0.000434511774017692,FALSE +"A549","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.40274,-1.14,0.28,8145,0.671,"CALML3, CALM2, PRKG2, CLCA2",0.552841968657781,0.173277479831008,FALSE +"A549","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.36659,-1.05,0.363,6727,0.701,"GART, MTR, SHMT1, DHFR, MTHFD2L, MTHFR, AMT, TYMS, ALDH1L1",0.440093374963888,0.154281982033341,FALSE +"A549","Input","KEGG_OOCYTE_MEIOSIS",-0.26978,-0.777,0.74,7793,0.859,"PPP2R5B, CDK2, AURKA, CCNB1, MOS, CALML3, SMC1A, SMC3, CALM2, PPP2R1B, PLK1, CDK1, MAPK1, PPP2R5A, PTTG1, MAPK3, RPS6KA1, MAPK12",0.130768280269024,0.0660068361687577,FALSE +"A549","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.43545,-1.24,0.2,6677,0.665,"AGA, GBA, MAN2B1, NEU1, MAN2B2, FUCA2, HEXB, FUCA1, MANBA",0.698970004336019,0.177178354696895,FALSE +"A549","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.21682,-0.619,0.937,6657,1,"COX6C, NDUFB5, NDUFB1, ATP5F1C, CYC1, ATP5PB, COX7A2, ATP5MG, TCIRG1, ATP6V0C, ATP6V0D1, PPA2, ATP6V0A1, PPA1, ATP6AP1, ATP6V1C1, ATP6V1E1, ATP6V1B2, ATP6V1F, COX7C, ATP6V1A, ATP12A, ATP6V1H, ATP6V1D, ATP6V1B1, ATP6V1G1",0.0282604091122217,0,FALSE +"A549","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.36079,-1.04,0.362,8426,0.697,"GALNT5, GALNT12, ST6GALNAC1, ST3GAL2, GCNT1, ST3GAL1, GALNT6, GALNT3",0.441291429466834,0.156767221901991,FALSE +"A549","Input","KEGG_P53_SIGNALING_PATHWAY",0.28525,0.829,0.676,542,0.846,"TP53I3, CDKN1A, SERPINE1, MDM2, ZMAT3, CCNB3, DDB2",0.170053304058364,0.0726296369609765,FALSE +"A549","Input","KEGG_PANCREATIC_CANCER",-0.31114,-0.88,0.578,7566,0.798,"MAPK10, BRAF, RAC1, RAF1, PIK3R1, RALBP1, KRAS, PIK3CA, RALA, E2F1, PIK3CB, ARHGEF6, NFKB1, AKT1, MAPK1, CDKN2A, ERBB2, RAD51, MAPK3, RAC2",0.238072161579471,0.0979971086492706,FALSE +"A549","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.3068,-0.876,0.584,7354,0.796,"COASY, PANK3, PANK4, PPCS",0.233587152887601,0.0990869322623309,FALSE +"A549","Input","KEGG_PARKINSONS_DISEASE",-0.13765,-0.394,1,8618,1,"COX7C, CASP3, SNCA, UBE2L6, UBA7",0,0,FALSE +"A549","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.22644,0.674,0.91,1500,0.97,"ITGB1, TUBB2B, TUBA4A, YWHAQ, PRKCA, CD14, TUBB6, ACTB",0.0409586076789064,0.0132282657337552,FALSE +"A549","Input","KEGG_PATHWAYS_IN_CANCER",0.29415,0.853,0.615,1020,0.862,"FGF13, FGF2, COL4A1, FZD2, CDKN1A, COL4A2, ITGA3, TGFB2, ITGB1, AKT3, LAMB1, PRKCG, ITGAV, FN1, MDM2, DAPK3, TGFBR2, AR, DAPK1, PRKCB, TGFBR1, FZD7, KITLG, LAMA5, EGLN1, BAD, SUFU, MITF, IGF1R, SMAD3, BCL2L1",0.211124884224583,0.0644927341752872,FALSE +"A549","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.39768,1.15,0.246,747,0.643,"AKR1B1, UGDH",0.609064892896621,0.191789027075778,FALSE +"A549","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.44452,-1.28,0.173,8377,0.667,"PGM1, ALDOB, PGLS, FBP2, FBP1, PGM2, PFKL, ALDOC",0.761953896871205,0.175874166083451,FALSE +"A549","Input","KEGG_PEROXISOME",-0.22017,-0.619,0.942,8477,1,"FAR2, FAR1, PXMP4, PMVK, ACSL1, ABCD1, IDH2, ACSL5, NUDT12, DDO",0.0259490972071227,0,FALSE +"A549","Input","KEGG_PHENYLALANINE_METABOLISM",0.41027,1.23,0.196,222,0.636,"ALDH3A1, ALDH3B1",0.707743928643524,0.196542884351586,FALSE +"A549","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.34104,-0.987,0.446,8099,0.741,"PIK3C3, PIK3CA, CALML3, PLCB2, PLCG2, ITPKA, PLCB1, ITPK1, PIK3CB, DGKH, CALM2, PIK3C2B, PI4KB, SYNJ1, INPP5B, IMPA2, DGKQ, PLCB3, INPP5D, CDS1",0.350665141287858,0.130181792020672,FALSE +"A549","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.28214,0.838,0.648,1831,0.843,"HMOX1, COX15, CPOX, FECH, HCCS",0.188424994129407,0.0741724253752577,FALSE +"A549","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.47291,-1.35,0.145,8533,0.637,"ACADM, FABP1, FABP2, ACSL1, SCD, CYP27A1, CPT2, DBI, GK, PDPK1, HMGCS2, FABP6, ACSL5, PLTP, LPL",0.838631997765025,0.19586056766465,FALSE +"A549","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.316,-0.902,0.553,7958,0.782,"TAP2, BTK, PTPRC, LCK",0.257274868695302,0.106793246940152,FALSE +"A549","Input","KEGG_PRION_DISEASES",-0.32726,-0.945,0.499,8788,0.764,"MAPK1, MAPK3, NCAM1, IL1A",0.30189945437661,0.11690664142431,FALSE +"A549","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.29023,-0.832,0.661,7090,0.81,"MAPK9, MAP2K1, HSP90AB1, PIK3CD, GNAI2, PKMYT1, CCNA2, MAPK10, BRAF, RAF1, CDK2, PIK3R1, CCNB1, KRAS, PIK3CA, MOS, MAPK14, PIK3CB, FZR1, PLK1, CDK1, AKT1, MAPK1, MAPK3, RPS6KA1, MAPK12",0.17979854051436,0.0915149811213502,FALSE +"A549","Input","KEGG_PROPANOATE_METABOLISM",-0.32193,-0.928,0.521,7870,0.769,"PCCA, ACSS3, ALDH6A1, ALDH9A1, ACSS1, ACADM, ACAT2, ABAT, ACSS2",0.283162276700476,0.114073660198569,FALSE +"A549","Input","KEGG_PROSTATE_CANCER",-0.32041,-0.92,0.538,7112,0.775,"SOS1, MAP2K1, HSP90AB1, CREB5, PIK3CD, GSTP1, MAP2K2, BRAF, GSK3B, RAF1, CDK2, CTNNB1, PIK3R1, CREB3L2, KRAS, NRAS, PIK3CA, PDGFC, NFKBIA, E2F1, PIK3CB, NFKB1, AKT1, MAPK1, ERBB2, FOXO1, FGFR2, MAPK3, PDPK1, BCL2",0.269217724333611,0.11069829749369,FALSE +"A549","Input","KEGG_PROTEASOME",-0.36966,-1.06,0.343,9089,0.704,"PSME2, PSME1, PSMB8, PSMB10",0.464705879957229,0.152427340857888,FALSE +"A549","Input","KEGG_PROTEIN_EXPORT",0.18109,0.552,0.988,479,0.986,"SEC61A2",0.00524305541237188,0.0061230850587888,FALSE +"A549","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.4405,-1.25,0.176,7927,0.689,"ATP1B1, MDH1, ATP1A1, ATP1A4, ATP1A3, ATP1B3, SLC38A3, CA2",0.75448733218585,0.161780778092374,FALSE +"A549","Input","KEGG_PURINE_METABOLISM",0.24822,0.747,0.81,2719,0.932,"NME4, PDE4D, PAPSS2, ADA, POLR2D, PFAS, ADCY3, ADCY8, NPR2, POLR1E, PDE6C, NT5C, PDE8A, POLE3, POLE4, PKM, ENPP1, POLR2L, PRPS1, PRPS1L1, POLR3H, RRM2B, POLR2I, PDE1C, PDE8B, POLR3D, POLA2, POLD4, POLD3, AK4, PKLR, POLD1, POLR2E, NME2, NME1, POLA1, POLR2G, PRIM2, PNPT1, POLD2, PRIM1",0.0915149811213502,0.0305840876460186,FALSE +"A549","Input","KEGG_PYRIMIDINE_METABOLISM",0.23836,0.727,0.845,2719,0.937,"NME4, CTPS1, POLR2D, CDA, POLR1E, NT5C, TXNRD1, POLE3, POLE4, POLR2L, POLR3H, RRM2B, POLR2I, POLR3D, POLA2, POLD4, POLD3, CAD, POLD1, POLR2E, NME2, NME1, POLA1, POLR2G, PRIM2, PNPT1, POLD2, PRIM1",0.0731432910503077,0.0282604091122217,FALSE +"A549","Input","KEGG_PYRUVATE_METABOLISM",0.28395,0.846,0.652,2381,0.859,"AKR1B1, ALDH2, ALDH1B1, ME3, ALDH3A2, PKM, HAGH, GRHPR, ME2, ALDH7A1, LDHA, PC, PKLR",0.18575240426808,0.0660068361687577,FALSE +"A549","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.24462,0.715,0.839,911,0.926,"FGF13, FGF2, MYLK, ITGA3, ITGA5, ITGB1, ITGB5, ITGAV, FN1, ITGB3, RDX, ACTN1, ACTN4, CFL2, PPP1R12A, MSN, RRAS, ARHGEF4, GNA13, ITGA1",0.0762380391712997,0.0333890133180656,FALSE +"A549","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.40139,-1.15,0.262,6945,0.755,"ATG7, PIK3R4, BECN1, PRKAA1, ATG4A, PIK3C3, GABARAPL1, GABARAPL2",0.581698708680255,0.122053048370812,FALSE +"A549","Input","KEGG_RENAL_CELL_CARCINOMA",-0.34015,-0.975,0.434,7111,0.722,"HGF, SOS1, MAP2K1, PIK3CD, RAP1B, RAPGEF1, MAP2K2, BRAF, RAC1, PAK2, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PAK3, CRKL, PAK1, PIK3CB, FLCN, AKT1, MAPK1, MAPK3, PAK5, PAK6",0.362510270487489,0.141462802430361,FALSE +"A549","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.32666,0.978,0.449,717,0.711,"ENPEP, NLN",0.347753658996677,0.148130399270234,FALSE +"A549","Input","KEGG_RETINOL_METABOLISM",0.37317,1.1,0.297,1303,0.64,"ALDH1A1, ALDH1A2, DHRS3, RETSAT, RDH10",0.527243550682788,0.193820026016113,FALSE +"A549","Input","KEGG_RIBOFLAVIN_METABOLISM",0.4058,1.21,0.205,1653,0.622,"RFK, ENPP1",0.688246138944246,0.206209615309181,FALSE +"A549","Input","KEGG_RIBOSOME",0.57171,1.7,0.036,3500,0.409,"RPS4Y1, RPL22L1, RPL35, RPL36, RPS6, RPL32, RPL18, RPLP2, RPL24, RSL24D1, RPS24, RPL28, RPS8, RPS12, RPL7A, RPL26, RPL18A, RPL13A, RPSA, RPL17, RPL36A, RPL36AL, RPL35A, RPL6, RPL23A, RPL9, RPL27A, RPL31, RPL21, RPL23, RPL22, RPS3A, RPS26, RPL12, RPL34, RPL37A, RPS28, RPL10A, RPL4, RPL3, RPS2, RPL7, FAU, RPL29, RPS18, RPL27, RPS4X, RPS29, RPL5, RPL11, RPS15A, RPL14, RPL30, MRPL13, RPL13, RPL8, RPS9, RPS15, RPS3, RPS17, RPLP0, RPS23",1.44369749923271,0.388276691992658,FALSE +"A549","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.34822,-1.01,0.408,8229,0.727,"MAPK14, NFKBIA, FADD, SIKE1, NFKB1, IFIH1, DDX58, DHX58, ISG15, MAPK12",0.38933983691012,0.138465589140962,FALSE +"A549","Input","KEGG_RNA_DEGRADATION",0.36616,1.07,0.337,2448,0.607,"TENT4A, PARN, ZCCHC7, MPHOSPH6, TTC37, EXOSC1, C1D, ENO3, SKIV2L, XRN2, EXOSC8, PAPOLG, EXOSC5, EXOSC10, MTREX, EXOSC9, EXOSC4, EXOSC3, DCP1B, EXOSC7, EXOSC6",0.472370099128661,0.216811308924742,FALSE +"A549","Input","KEGG_RNA_POLYMERASE",0.51095,1.47,0.103,4124,0.445,"POLR2D, POLR1E, POLR2L, POLR3H, POLR2I, POLR3D, POLR2E, POLR2G, POLR3A, POLR3C, POLR3G, POLR1A, POLR3GL, POLR3F, POLR3K, POLR3B",0.987162775294828,0.351639989019068,FALSE +"A549","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.27573,0.814,0.702,1692,0.846,"GGT1, PAPSS2, MAT2A, MAT1A, GGT5",0.153662887870195,0.0726296369609765,FALSE +"A549","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.35319,1.04,0.393,376,0.636,"COL4A1, COL4A2, ITGA3, ITGB1, AKT3, LAMB1, ITGAV, FN1",0.405607449624573,0.196542884351586,FALSE +"A549","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.29286,-0.836,0.666,7613,0.811,"STX6, STX18, SNAP23, STX16, SEC22B, SNAP47, STX12, STX7, SNAP29, VAMP4, YKT6, VAMP8, STX3, VAMP5",0.176525770829699,0.090979145788844,FALSE +"A549","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.29964,-0.858,0.605,9645,0.785,"SMPD3, UGT8",0.218244625347531,0.105130343254747,FALSE +"A549","Input","KEGG_SPLICEOSOME",0.21371,0.639,0.932,6295,0.993,"HSPA2, HSPA1L, DDX42, TRA2A, SNRPD3, SNRPB, U2AF1, DDX46, SRSF9, DDX23, SNRPG, PUF60, SF3B5, U2AF2, SNU13, THOC1, DDX5, SNRPF, HNRNPA1, RBMX, SRSF7, THOC3, SNRNP70, SF3A1, HNRNPC, SNRPC, SF3B6, SF3A2, SRSF2, SNRPA, SMNDC1, SNRPD1, SNRPD2, SF3A3, THOC2, CHERP, SF3B1, PRPF8, SRSF3, SRSF8, EFTUD2, DDX39B, HSPA6, HNRNPA3, SRSF1, TCERG1, LSM2, PHF5A, TRA2B, NCBP2, PPIL1, SNRPE, NCBP1, SNW1, SRSF4, PRPF3, HSPA8, ALYREF, SNRNP40, SRSF10, USP39, HNRNPK, RBM22, RBM17, PRPF40A, SF3B4, CDC5L, SNRNP200, RBM25, PLRG1, PRPF19, HSPA1A, DHX38, PQBP1, SF3B2, PRPF31, CRNKL1, CTNNBL1, HNRNPM, TXNL4A, PRPF4, RBM8A, ZMAT2, U2SURP, SNRPA1, ACIN1, SF3B3, BCAS2, LSM4, XAB2, DHX8, AQR, SNRPB2, CCDC12, WBP11, PRPF40B, SRSF5, EIF4A3, LSM3, SART1, SLU7, LSM7, ISY1, LSM8, PCBP1, PRPF38B, DHX15, SRSF6, DHX16, PRPF6, SYF2, PPIH, LSM6",0.0305840876460186,0.00305075150461883,FALSE +"A549","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.40793,-1.17,0.237,8377,0.791,"PGM1, GYS1, UGT2B17, AGL, HK2, GCK, PGM2, HK1",0.625251653989896,0.101823516502323,FALSE +"A549","Input","KEGG_STEROID_BIOSYNTHESIS",-0.72831,-2.08,0.0018,8256,0.261,"HSD17B7, CEL, LIPA, MSMO1, SOAT2, DHCR7, FDFT1, CYP27B1, SC5D, DHCR24",2.74472749489669,0.583359492661719,FALSE +"A549","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.37622,-1.08,0.309,9676,0.702,"HSD11B2, SULT1E1, HSD17B2",0.510041520575165,0.153662887870195,FALSE +"A549","Input","KEGG_SULFUR_METABOLISM",-0.6033,-1.73,0.0484,9422,0.564,"BPNT1, SULT1E1",1.31515463835559,0.248720896016658,FALSE +"A549","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.72897,2.12,0.0068,1814,0.304,"C1S, C9, ACTN1, ACTN4, C1R, CD40, C4A, SNRPD3, SNRPB",2.16749108729376,0.517126416391246,FALSE +"A549","Input","KEGG_TASTE_TRANSDUCTION",-0.433,-1.22,0.196,9776,0.691,"SCNN1A",0.707743928643524,0.160521952625802,FALSE +"A549","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.72157,-2.05,0.00525,8203,0.214,"MVK, GGPS1, PMVK, IDI1, ACAT2, MVD, HMGCR, FDPS, HMGCS2",2.27984069659404,0.669586226650809,TRUE +"A549","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.29945,0.88,0.586,1868,0.837,"TGFB2, TGFBR2, TGFBR1, ACVR1, SMAD3, SMAD2, ID1, ZFYVE16, SMURF2, ROCK2, INHBA",0.232102383981909,0.07727454200674,FALSE +"A549","Input","KEGG_THYROID_CANCER",-0.50713,-1.44,0.0938,6880,0.67,"TCF7L2, MAP2K1, CCDC6, RXRA, RXRB, MAP2K2, BRAF, CTNNB1, NCOA4, KRAS, NRAS, CDH1, MAPK1, MAPK3",1.02779716162094,0.173925197299174,FALSE +"A549","Input","KEGG_TIGHT_JUNCTION",-0.403,-1.14,0.25,8041,0.671,"KRAS, NRAS, OCLN, PRKCI, PARD6A, AFDN, F11R, CTNNA1, PRKCD, TJAP1, PPP2R1B, AKT1, MYH7, EPB41, PATJ, ACTG1, PRKCZ, EPB41L3, MYH14, MYH7B, HCLS1, TJP3, CRB3, CGN, CLDN11, TJP2, CLDN3, CLDN7, CLDN4, CLDN18",0.602059991327962,0.173277479831008,FALSE +"A549","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.44005,-1.25,0.19,7315,0.689,"PIK3CD, TLR2, RIPK1, MYD88, MAP2K3, MAPK10, IL6, MAP2K2, RAC1, MAP3K7, PIK3R1, PIK3CA, MAPK14, IFNAR1, NFKBIA, IRAK4, FADD, PIK3CB, CTSK, NFKB1, AKT1, MAPK1, MAP2K7, MAPK3, FOS, TLR3, MAPK12",0.721246399047171,0.161780778092374,FALSE +"A549","Input","KEGG_TRYPTOPHAN_METABOLISM",0.31298,0.919,0.545,316,0.77,"KYNU, ALDH2, ALDH1B1",0.263603497723358,0.113509274827518,FALSE +"A549","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.29933,-0.866,0.606,7090,0.778,"MAPK9, PDX1, PIK3CD, MAPK10, PIK3R1, PIK3CA, PRKCD, PIK3CB, MAPK1, HK2, GCK, PRKCZ, MAPK3, HK1",0.217527375833714,0.109020403010311,FALSE +"A549","Input","KEGG_TYROSINE_METABOLISM",-0.47428,-1.33,0.148,8581,0.63,"LCMT1, MAOB, IL4I1, MIF, ALDH1A3, MAOA, ADH4, ADH7, ADH1C",0.829738284605043,0.200659450546418,FALSE +"A549","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.51039,-1.47,0.0739,7558,0.873,"NFKBIE, MAP2K2, PAK2, VAV2, GSK3B, RAF1, MAP3K7, PIK3R1, DLG1, KRAS, NRAS, VAV1, PTPRC, PIK3CA, PAK3, MAPK14, NCK2, CBLB, PTPN6, BCL10, NFKBIA, VAV3, PAK1, PIK3CB, NFKB1, AKT1, MAPK1, MAP2K7, MAPK3, PDPK1, CBL, FOS, LCK, PAK5, PAK6, CARD11, NFATC2, MAPK12",1.13135556160517,0.0589857562944303,FALSE +"A549","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.21024,-0.613,0.955,7832,1,"UBE2Q1, UBE2NL, UBE3A, UBE2L3, UBE4A, CUL7, UBE2D4, FBXO2, UBE2B, CBLB, PML, UBE2K, WWP2, FZR1, UBA6, UBE2C, CBL, RCHY1, UBE2L6, KEAP1, UBA7",0.0199966284162537,0,FALSE +"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.30756,0.872,0.587,6795,0.837,"BCAT2, PDHA1, PDHB, IARS2, BCAT1, VARS2, LARS2",0.231361898752386,0.07727454200674,FALSE +"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.37201,-1.06,0.343,6530,0.704,"EHHADH, BCAT1, BCKDHB, HMGCL, HADH, HADHA, PCCB, HMGCS1, DLD, MCCC2, PCCA, ALDH6A1, DBT, ALDH9A1, ACAD8, ACADM, ACAT2, IL4I1, IVD, MCCC1, ABAT, HMGCS2, OXCT1",0.464705879957229,0.152427340857888,FALSE +"A549","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.47889,1.43,0.0979,1975,0.479,"PPP1R14A, CALD1, MYLK, PLCB4, KCNMA1, PRKCG, PLA2G4A, ITPR1, PPP1R12A, PRKCB, PRKCH, PPP1R12B, ADCY3, ADCY8, GNA13, PRKCQ, PRKCE, NPR2, MYL6, GNAQ, PRKACA, PRKCA, MYL6B, MYH11, ACTA2, ARHGEF1, ROCK2, MYL9, GNA12, PPP1CB",1.00921730819686,0.319664486585437,FALSE +"A549","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.17061,-0.491,0.998,7555,1,"AQP3, ARHGDIA, CREB3L2, AVP, RAB11B, ARHGDIB",0.000869458712628891,0,FALSE +"A549","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.3919,-1.13,0.263,7636,0.678,"MAP2K2, RAC1, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, MAPK14, PLCG2, SPHK1, MAPKAPK2, PIK3CB, AKT1, MAPK1, MAPKAPK3, PLA2G12A, MAPK3, NFATC2, PLA2G2A, MAPK12, RAC2",0.580044251510242,0.168770306132937,FALSE +"A549","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.33882,-0.985,0.432,8257,0.735,"PLCG2, ATP6AP1, ATP6V1C1, ATP6V1E1, ATP6V1B2, ATP6V1F, ERO1A, ATP6V1A, ATP6V1H, ATP6V1D, ACTG1, ATP6V1B1, ATP6V1G1, TJP2",0.364516253185088,0.133712660915805,FALSE +"A549","Input","KEGG_VIRAL_MYOCARDITIS",-0.39183,-1.12,0.286,8578,0.671,"ICAM1, CASP3, MYH7, ACTG1, MYH14, MYH7B, ITGAL, RAC2",0.543633966870957,0.173277479831008,FALSE +"A549","Input","KEGG_WNT_SIGNALING_PATHWAY",0.21665,0.637,0.942,1261,0.979,"FZD2, PLCB4, PRKCG, DKK1, NKD2, LRP6, MMP7, PRKCB, FZD7, SMAD3, PPP3R1, SMAD2, PRKACA, PRKCA",0.0259490972071227,0.00921730819686218,FALSE +"HCC15","Input","KEGG_ABC_TRANSPORTERS",0.70761,2.23,0,705,0.11,"ABCC2, ABCC3, ABCG2, ABCD1, ABCA3, ABCC1, ABCA13, TAP2, ABCB6",Inf,0.958607314841775,TRUE +"HCC15","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.34599,-1.09,0.315,7526,0.948,"NFKB1, CCND1, PIK3CD, PIK3CB, SOS1, RUNX1, TCF7L1, RAF1, PIK3R2, RUNX1T1, CEBPA, AKT3, PIK3CG, GRB2, SPI1, EIF4EBP1",0.501689446210399,0.0231916626619338,FALSE +"HCC15","Input","KEGG_ADHERENS_JUNCTION",0.32027,1.04,0.365,926,0.518,"TJP1, PTPRJ, TGFBR2, EGFR, PTPRB, ACTN4, CDH1, IQGAP1, CTNNB1, CTNND1, CTNNA2, CTNNA1, PTPN1, NECTIN2",0.437707135543525,0.285670240254767,FALSE +"HCC15","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.48884,1.49,0.0917,2462,0.306,"SLC2A1, ACSL3, LEPR, IRS1, PRKAG1, AKT1, ACACB, CHUK, PRKAA1, MAPK8, ACSL1, STK11, PRKAG2, ADIPOR1, MAPK9, PRKAB1, CPT1A, NFKBIB, AKT2, MAPK10, TRAF2, TNFRSF1A, ACSL6",1.03763066432998,0.51427857351842,FALSE +"HCC15","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.39279,1.24,0.207,1685,0.393,"ASS1, CPS1, GPT, GLUD1, GOT1, ALDH4A1, GFPT1, PPAT, ALDH5A1, GOT2",0.684029654543082,0.405607449624573,FALSE +"HCC15","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.3622,1.14,0.239,478,0.462,"ATP1B1, PIK3R3, SLC9A3R2, IRS1, SFN",0.621602099051862,0.335358024443874,FALSE +"HCC15","Input","KEGG_ALZHEIMERS_DISEASE",-0.20356,-0.642,0.93,8137,1,"IL1B, UQCRC2, NDUFS4, UQCR10, APP, GSK3B, PLCB2, LRP1, GRIN1, UQCRB, APOE, MME, UQCRFS1, UQCRQ, ATP2A3, LPL, ATP2A1, SNCA",0.0315170514460649,0,FALSE +"HCC15","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.376,1.2,0.208,2253,0.422,"IARS2, RARS2, SARS2, MARS2, YARS2, NARS2, MTFMT, EARS2, DARS2, FARSB",0.681936665037238,0.374687549038326,FALSE +"HCC15","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.30031,0.963,0.453,1513,0.575,"UGDH, GNPNAT1, HEXA, PGM3, GNPDA2, PMM2, GALE, GFPT1",0.343901797987168,0.24033215531037,FALSE +"HCC15","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.343,1.06,0.368,2652,0.522,"MAPK13, BCL2L1, APAF1, MAP2K6, RAB5A, TP53, DERL1, PRPH, PRPH2, PPP3CC, TNFRSF1A, CASP1, TOMM40, BAD, CAT",0.434152181326482,0.282329496997738,FALSE +"HCC15","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.3367,1.05,0.359,1309,0.523,"B2M, HSPA1L, HSPA2, CTSL, TAP2, LGMN, HSPA6, TAPBP, PSME2, HSPA1A",0.444905551421681,0.281498311132726,FALSE +"HCC15","Input","KEGG_APOPTOSIS",0.29657,0.93,0.497,1161,0.603,"IL1A, TNFRSF10A, BCL2L1, CAPN2, PIK3R3, CAPN1, AKT1, ENDOD1, CHUK, ATM, BIRC2, APAF1, CASP7",0.303643611266668,0.219682687859849,FALSE +"HCC15","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.57412,1.84,0.0204,746,0.279,"AKR1C3, GGT1, LTA4H, PTGES, CBR3, CBR1, PTGS2",1.6903698325741,0.554395796726402,FALSE +"HCC15","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.27417,0.857,0.625,1685,0.69,"ASS1, ODC1, ALDH2, CPS1, MAOA, ALDH3A2, ALDH7A1, GLUD1, GAMT, GOT1, ALDH4A1, ALDH9A1, SAT2, GOT2",0.204119982655925,0.161150909262745,FALSE +"HCC15","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.45423,1.43,0.115,897,0.303,"ITGA1, PKP2, ITGB5, ACTN4, ITGB4, DMD, CDH2, ITGA6, ITGA3, ITGA2, CTNNB1, DES, CTNNA2, CACNA1C, CTNNA1, LMNA",0.939302159646388,0.518557371497695,FALSE +"HCC15","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.7467,2.37,0,1421,0.056,"ALDH2, UGDH, ALDH3A2, ALDH7A1, ALDH9A1",Inf,1.2518119729938,TRUE +"HCC15","Input","KEGG_AXON_GUIDANCE",-0.25068,-0.786,0.716,7564,0.962,"RGS3, ROCK1, RHOA, PLXNB1, NFATC4, EPHA1, NCK2, PAK3, PAK1, NFATC1, SEMA4A, GSK3B, RAC2, DPYSL5, L1CAM, NFATC2, ROBO1, FES, NTNG1, NCK1, RAC3, NTN4, UNC5B, SEMA7A, PLXNA1",0.145086977692144,0.0168249279621871,FALSE +"HCC15","Input","KEGG_BASAL_CELL_CARCINOMA",0.27273,0.869,0.616,2498,0.683,"FZD6, CTNNB1, APC, TP53, SMO, DVL2, AXIN1, STK36, BMP4",0.210419287835575,0.165579296318467,FALSE +"HCC15","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.36818,-1.14,0.258,6612,0.89,"TAF1, TAF9B, TAF10, TAF5, TAF6, GTF2F1, TAF9, TAF4, GTF2B, GTF2E1, GTF2E2, TAF12, GTF2F2, TAF7",0.58838029403677,0.0506099933550872,FALSE +"HCC15","Input","KEGG_BASE_EXCISION_REPAIR",-0.28007,-0.873,0.581,7320,0.905,"APEX1, MBD4, PARP1, POLB, SMUG1, TDG, MPG, NEIL2",0.235823867609669,0.0433514207947967,FALSE +"HCC15","Input","KEGG_BETA_ALANINE_METABOLISM",0.41599,1.3,0.154,1421,0.366,"ALDH2, ALDH3A2, ALDH7A1, ECHS1, EHHADH, ALDH9A1",0.812479279163537,0.436518914605589,FALSE +"HCC15","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.40036,-1.25,0.174,8886,0.9,"SCD, FADS2, ELOVL6, SCD5",0.7594507517174,0.0457574905606751,FALSE +"HCC15","Input","KEGG_BLADDER_CANCER",-0.32802,-1.01,0.414,8344,0.917,"E2F3, RAF1, CDK4, MDM2, MMP2, VEGFA, RB1, CDKN2A",0.382999658879101,0.0376306643299789,FALSE +"HCC15","Input","KEGG_BUTANOATE_METABOLISM",0.32717,1.01,0.367,1602,0.552,"ALDH2, AACS, ACADS, ALDH3A2, ALDH7A1, ECHS1, EHHADH, ALDH9A1, ALDH5A1",0.435333935747911,0.258060922270801,FALSE +"HCC15","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.39899,-1.23,0.2,8272,0.79,"NFATC1, GSK3B, CD81, PLCG2, RAF1, BTK, RAC2, PIK3R2, PRKCB, AKT3, VAV3, NFATC2, CD79A, PIK3CG, GRB2, RAC3, PIK3AP1, FCGR2B, INPP5D, CD79B",0.698970004336019,0.102372908709559,FALSE +"HCC15","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.336,-1.07,0.327,8465,0.925,"PLCG1, PLCG2, TNNC1, PLCB2, PRKCB, RYR1, GRIN1, MYLK, PDGFRB, PDE1C, ATP2A3, PLCZ1, ATP2A1, CAMK4, BST1, SLC8A1",0.485452247339714,0.0338582672609674,FALSE +"HCC15","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.4178,-1.3,0.151,8212,0.981,"UQCRC2, CACNB3, UQCR10, ATP1B3, TNNC1, UQCRB, UQCRFS1, UQCRQ, TPM2, CACNA2D1, SLC8A1",0.821023052706831,0.0083309926200515,FALSE +"HCC15","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.39663,1.23,0.19,926,0.398,"CLDN6, ICAM2, CD274, CADM1, CD40, OCLN, CDH1, CD99, CDH2, SDC4, CDH4, ITGA6, NEGR1, ICAM1, CLDN1, MPZ, MPZL1, NECTIN2",0.721246399047171,0.400116927926312,FALSE +"HCC15","Input","KEGG_CELL_CYCLE",-0.27195,-0.83,0.674,7699,0.923,"PTTG1, CDKN1A, CDC20, CDKN1B, CREBBP, TFDP2, DBF4, GSK3B, E2F3, CHEK2, ZBTB17, E2F4, BUB1, CCND2, ORC6, CDK4, MDM2, SKP2, SMAD4, E2F5, TFDP1, RB1, EP300, CDKN2A",0.17134010346468,0.0347982989740879,FALSE +"HCC15","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.17974,0.568,0.982,1425,0.978,"CXCL8, ARRB1, PIK3R3, STAT1, GNAI1, ADCY9, AKT1, ADCY5, ROCK2, GNG2, CCL13, RASGRP2, CHUK, GNG12, ADCY6, VAV2, SHC1",0.00788851221305034,0.00966114521239857,FALSE +"HCC15","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.33954,-1.05,0.389,7526,0.943,"NFKB1, BCR, CCND1, PIK3CD, PIK3CB, CDKN1A, CTBP1, CDKN1B, SOS1, MECOM, RUNX1, E2F3, RAF1, PIK3R2, CDK4, MDM2, AKT3, SMAD4, PIK3CG, CBLB, GRB2, RB1, CDKN2A",0.410050398674292,0.0254883072626717,FALSE +"HCC15","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.46598,1.47,0.0909,1738,0.307,"PC, IDH3G, OGDH, OGDHL, DLAT, CS, IDH3B, FH, IDH3A, SDHC",1.04143611677803,0.512861624522813,FALSE +"HCC15","Input","KEGG_COLORECTAL_CANCER",-0.19612,-0.607,0.945,6493,1,"TGFB1, CASP3, TGFB2, CYCS, MAPK1, BRAF, PIK3R1, FOS, APPL1, CCND1, PIK3CD, PIK3CB, RHOA, BIRC5, GSK3B, TCF7L1, RAF1, RAC2, PIK3R2, AKT3, SMAD4, PIK3CG, RAC3",0.0245681914907371,0,FALSE +"HCC15","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.41377,1.3,0.154,1274,0.366,"THBD, PLAUR, MBL2, F2R, C9, PLAU, CFH, SERPINA1, PROC, CD46, CD59, TFPI",0.812479279163537,0.436518914605589,FALSE +"HCC15","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.29763,0.943,0.486,1685,0.594,"MAT1A, CBS, APIP, GOT1, SDS, LDHA, GOT2",0.313363730737707,0.226213555018806,FALSE +"HCC15","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.47072,1.48,0.0772,890,0.306,"IL1A, TNFRSF12A, TNFRSF19, TNFRSF21, IFNGR1, IL18, TNFRSF10A, CXCL8, TGFBR2, EGFR, CD40, KIT, LEPR, BMPR1A, IL13RA1, BMPR2, OSMR, CCL13",1.11238269966426,0.51427857351842,FALSE +"HCC15","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.34526,1.09,0.317,1168,0.512,"ZBP1, IL18, DDX58, CHUK, RIPK3, PYCARD",0.498940737782249,0.290730039024169,FALSE +"HCC15","Input","KEGG_DILATED_CARDIOMYOPATHY",0.34044,1.04,0.359,897,0.518,"ITGA1, ITGB5, ITGB4, DMD, ITGA6, ITGA3, ITGA2, ADCY9, DES, ADCY5, CACNA1C, LMNA",0.444905551421681,0.285670240254767,FALSE +"HCC15","Input","KEGG_DNA_REPLICATION",0.3924,1.24,0.202,3223,0.393,"POLD1, LIG1, MCM6, MCM5, MCM3, MCM7, RFC1, POLA1, MCM4, POLE4, POLD3, POLE2, FEN1, POLA2, SSBP1, POLE, PRIM1, MCM2, PRIM2",0.694648630553376,0.405607449624573,FALSE +"HCC15","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.33996,1.04,0.368,201,0.518,"PIWIL1, EGFR",0.434152181326482,0.285670240254767,FALSE +"HCC15","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.55855,1.71,0.0468,1069,0.246,"ALDH3A1, GSTM4, GSTM3, GSTM2, CYP3A7, MAOA, ALDH3B1, MGST1",1.32975414692588,0.609064892896621,TRUE +"HCC15","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.49619,1.55,0.0686,360,0.279,"CES1, CES2, CDA, UPP1, CYP3A7",1.16367588429325,0.554395796726402,FALSE +"HCC15","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.4732,-1.47,0.101,8261,0.886,"LAMC1, COL6A2, ITGA5, HSPG2, COL2A1, ITGA4, TNXB, COL6A3, TNC, COL3A1, CD47, VTN, FN1, COL6A1, COL5A1, SDC2, COL1A1, ITGB3, THBS3, LAMB1, ITGA7, SV2A, COL4A2, SDC1, COL1A2, ITGB8",0.995678626217357,0.0525662781129492,FALSE +"HCC15","Input","KEGG_ENDOCYTOSIS",0.34167,1.08,0.316,2148,0.52,"DNM3, EGFR, SMURF1, KIT, HSPA1L, EHD4, ARRB1, SMURF2, HSPA2, F2R, RAB11FIP5, ERBB4, DNM1, RAB11A, WWP1, AP2S1, RAB11FIP2, HSPA6, EHD1, AP2A2, ASAP2, EHD2, RAB5C, NEDD4, PLD2, RAB5A, AP2M1, HSPA1A, RAB31, IQSEC2, CLTC, AP2B1, CLTB, IGF1R, ARF6, EEA1, ITCH, PIP5K1A, HRAS, MVB12B, AP2A1, CHMP2A, EHD3, DAB2, RAB5B, SH3GLB2, USP8",0.500312917381596,0.283996656365201,FALSE +"HCC15","Input","KEGG_ENDOMETRIAL_CANCER",0.23855,0.74,0.758,813,0.829,"EGFR, CDH1, PIK3R3, CTNNB1, AKT1, CTNNA2, CTNNA1",0.120330794367946,0.0814454694497265,FALSE +"HCC15","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.37547,1.16,0.247,1160,0.454,"MAPK13, TJP1, CXCL8, EGFR, TCIRG1, ATP6V0D1, ATP6V0A1, CHUK, MAPK8, ATP6V0A2, JUN",0.607303046740334,0.342944147142896,FALSE +"HCC15","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.264,-0.818,0.693,7470,0.93,"MAP2K7, PIK3CD, PIK3CB, CDKN1A, CDKN1B, SOS1, NCK2, PAK3, PAK1, GAB1, GSK3B, PLCG1, PLCG2, RAF1, PIK3R2, PRKCB, AKT3, PIK3CG, NCK1, CBLB, GRB2, EIF4EBP1",0.159266765388193,0.0315170514460649,FALSE +"HCC15","Input","KEGG_ETHER_LIPID_METABOLISM",0.56003,1.76,0.0394,1505,0.248,"PLPP2, PLPP3, AGPS, LPCAT1, PLD2, PAFAH1B1",1.40450377817443,0.605548319173784,TRUE +"HCC15","Input","KEGG_FATTY_ACID_METABOLISM",0.49015,1.55,0.0622,1022,0.279,"ALDH2, ECI1, ACSL3, ACADS, ACADSB, ALDH3A2, ALDH7A1, HADHB, ECHS1, EHHADH, ACSL1",1.20620961530918,0.554395796726402,FALSE +"HCC15","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.34917,-1.08,0.334,7470,0.936,"MAP2K7, MAP2K3, PRKCE, PIK3CD, PIK3CB, PDPK1, SOS1, LCP2, PLCG1, PLCG2, RAF1, BTK, RAC2, PIK3R2, PLA2G12A, PRKCB, AKT3, VAV3, PIK3CG, PRKCD, GRB2, RAC3, INPP5D",0.476253533188435,0.0287241512618947,FALSE +"HCC15","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.30888,-0.968,0.449,8465,0.968,"PLCG1, PLCG2, RAF1, RAC2, GSN, PIK3R2, PRKCB, AKT3, WASF1, VAV3, DOCK2, PIK3CG, PRKCD, PTPRC, FCGR2B, FCGR2C, INPP5D, MARCKSL1, WASF3",0.347753658996677,0.0141246426916063,FALSE +"HCC15","Input","KEGG_FOCAL_ADHESION",-0.29831,-0.924,0.513,7572,0.943,"CCND1, PIK3CD, COL11A1, ROCK1, PIK3CB, RHOA, PDPK1, THBS1, LAMB2, TLN1, HGF, SOS1, ACTN3, PAK3, PAK1, LAMC1, GSK3B, COL6A2, ITGA5, COL2A1, RAF1, ITGA4, TNXB, CCND2, RAC2, COL6A3, PIK3R2, TNC, PRKCB, COL3A1, MYLK, PDGFRB, AKT3, VTN, FN1, VAV3, PIK3CG, COL6A1, ACTG1, COL5A1, GRB2, COL1A1, RAC3, VEGFA, ITGB3, THBS3, LAMB1, ITGA7, COL4A2, COL1A2, ITGB8",0.289882634888184,0.0254883072626717,FALSE +"HCC15","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.40989,-1.27,0.169,7440,0.911,"FPGS, DHFR, ALPG, GCH1, ALPI, ALPP",0.772113295386326,0.0404816230270017,FALSE +"HCC15","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.31955,-0.989,0.401,8060,0.942,"MPI, PFKFB4, ALDOB, HK2, FBP1, FBP2, ALDOC",0.396855627379818,0.0259490972071227,FALSE +"HCC15","Input","KEGG_GALACTOSE_METABOLISM",0.30693,0.968,0.447,278,0.58,"PFKP, GLA",0.349692476868064,0.236572006437063,FALSE +"HCC15","Input","KEGG_GAP_JUNCTION",0.30337,0.98,0.438,711,0.567,"TJP1, TUBB2B, ITPR3, EGFR, GNAI1, ADCY9, ADCY5",0.3585258894959,0.246416941107093,FALSE +"HCC15","Input","KEGG_GLIOMA",-0.41747,-1.31,0.162,7572,1,"CCND1, PIK3CD, PIK3CB, CDKN1A, SOS1, E2F3, PLCG1, PLCG2, RAF1, PIK3R2, PRKCB, CDK4, PDGFRB, MDM2, AKT3, PIK3CG, GRB2, RB1, CDKN2A",0.790484985457369,0,FALSE +"HCC15","Input","KEGG_GLUTATHIONE_METABOLISM",0.4926,1.53,0.0729,505,0.287,"GCLC, GGT1, GSTM4, GSTM3, ODC1, GSTM2, GCLM, GSR, G6PD",1.13727247168203,0.542118103266008,FALSE +"HCC15","Input","KEGG_GLYCEROLIPID_METABOLISM",0.43127,1.35,0.129,961,0.341,"PLPP2, GLA, ALDH2, AGPAT3, CEL, PLPP3, GPAT3, ALDH3A2, ALDH7A1, DGKE",0.889410289700751,0.467245621007502,FALSE +"HCC15","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33289,1.05,0.36,1184,0.523,"PLPP2, MBOAT7, AGPAT3, PLPP3, GPAT3, GPD2, PTDSS2, DGKE, LPCAT1, PLD2, GNPAT",0.443697499232713,0.281498311132726,FALSE +"HCC15","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.54594,1.71,0.0394,1176,0.246,"ALAS1, GLDC, CBS, MAOA, SHMT1, GAMT, PHGDH, SDS",1.40450377817443,0.609064892896621,TRUE +"HCC15","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.35208,1.11,0.286,1802,0.489,"ALDH3A1, PFKP, ALDH2, ALDH3A2, ALDH3B1, ALDH7A1, DLAT, LDHA, ACSS2, ALDH9A1, PKLR, GALM, ENO3",0.543633966870957,0.31069114087638,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.47352,-1.48,0.0732,6273,0.999,"CHPF, CHST14, B3GALT6, CHSY1, UST, CHPF2, B3GAT3, DSE",1.13548891894161,0.000434511774017692,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.31687,1,0.418,134,0.554,"GLCE",0.378823718224965,0.25649023527157,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.28245,0.879,0.554,1373,0.674,"ST3GAL1, B4GAT1",0.25649023527157,0.17134010346468,FALSE +"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.37857,1.16,0.285,2467,0.454,"HEXA, GUSB, GALNS, NAGLU, GNS, IDUA, HGSNAT",0.54515513999149,0.342944147142896,FALSE +"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.55602,1.76,0.0237,871,0.248,"ST3GAL5, HEXA, ST3GAL1",1.6252516539899,0.605548319173784,TRUE +"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.64249,2.03,0.013,871,0.159,"GLA, HEXA, ST3GAL1",1.88605664769316,0.798602875679548,TRUE +"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.36335,1.15,0.27,1373,0.454,"ST3GAL4, B4GAT1",0.568636235841013,0.342944147142896,FALSE +"HCC15","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.27826,-0.88,0.583,7454,0.955,"GPAA1, PIGN, PIGO, PGAP1, PIGU",0.234331445240986,0.0199966284162537,FALSE +"HCC15","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.26821,0.843,0.64,1213,0.701,"HYI, CS",0.193820026016113,0.154281982033341,FALSE +"HCC15","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.28335,0.905,0.547,1334,0.641,"MAPK13, ITPR3, EGFR, ADCY9, ADCY5, CACNA1C, MAPK8, JUN, PLD2, MAP2K6, ITPR2, ADCY6",0.262012673666569,0.193141970481183,FALSE +"HCC15","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.20457,0.631,0.943,2498,0.953,"CSNK1G2, CSNK1G3, SMO, PRKACB, RAB23, CSNK1A1, STK36, BMP4",0.0254883072626717,0.0209070993616736,FALSE +"HCC15","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.40366,1.26,0.183,684,0.384,"ITGA1, IL1A, KIT, CD14, ITGA6, ITGA3, ITGA2, CD9",0.737548910269571,0.415668775632469,FALSE +"HCC15","Input","KEGG_HISTIDINE_METABOLISM",0.5574,1.76,0.039,829,0.248,"ALDH3A1, AMDHD1, ALDH2, MAOA, ALDH3A2, ALDH3B1, ALDH7A1",1.4089353929735,0.605548319173784,TRUE +"HCC15","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.22548,-0.697,0.868,6332,1,"RAD54L, TOP3B, BRCA2, RAD51, POLD4, RAD51B, XRCC3, SEM1, RAD52, RAD54B",0.0614802748235081,0,FALSE +"HCC15","Input","KEGG_HUNTINGTONS_DISEASE",-0.19488,-0.602,0.948,6353,1,"POLR2D, ATP5PO, CREB5, COX5B, ATP5F1E, GPX1, CASP3, HDAC1, CYCS, ATP5PD, NDUFV2, IFT57, POLR2E, NDUFA7, DLG4, COX7A2L, NDUFAB1, PLCB1, NDUFS6, COX6C, POLR2L, HDAC2, NDUFA6, NDUFS5, HAP1, POLR2C, CREB1, DNAL4, POLR2G, NRF1, TAF4, POLR2J, CREBBP, PPID, UQCRC2, NDUFS4, UQCR10, POLR2I, POLR2K, SP1, POLR2H, PLCB2, GRIN1, UQCRB, UQCRFS1, UQCRQ, POLR2F, DNAH3, REST, EP300",0.0231916626619338,0,FALSE +"HCC15","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.31101,0.992,0.434,1010,0.561,"ITGA1, ITGB5, ITGB4, DMD, ITGA6, ITGA3, ITGA2, PRKAG1, DES, CACNA1C, LMNA, PRKAA1",0.362510270487489,0.251037138743839,FALSE +"HCC15","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.33281,-1.03,0.387,7590,0.894,"PIK3CD, PI4KB, PIK3CB, INPP5B, PLCG1, PLCG2, PIP4K2A, IMPA2, PLCB2, INPP4B, PIK3CG, ALDH6A1, PLCZ1",0.412289034981089,0.0486624812040823,FALSE +"HCC15","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.19482,-0.604,0.947,7590,1,"PIK3CD, PIK3CB, PDPK1, INSR, EIF4E, SOS1, FOXO1, GSK3B, HK2, FBP1, RAF1, PIK3R2, FBP2, AKT3, PIK3CG, CBLB, GRB2, PRKAR2B, INPP5D, EIF4EBP1",0.0236500209967266,0,FALSE +"HCC15","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.59889,-1.82,0.0303,8608,0.558,"ITGA4, IL6, TNFRSF13C",1.5185573714977,0.253365801062421,FALSE +"HCC15","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.26103,0.818,0.676,1056,0.723,"IFNGR1, BCL2L1, PIK3R3, LEPR, STAT1, AKT1, IL13RA1, OSMR, IRF9, SPRED1, JAK1",0.170053304058364,0.140861702705469,FALSE +"HCC15","Input","KEGG_LEISHMANIA_INFECTION",0.33992,1.07,0.311,1160,0.528,"MAPK13, IL1A, IFNGR1, STAT1, PTGS2, JAK1, JUN",0.507239610973163,0.277366077466188,FALSE +"HCC15","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.30166,0.951,0.484,885,0.587,"MAPK13, CLDN6, OCLN, ACTN4, CD99, PIK3R3, GNAI1, ICAM1, CTNNB1, CTNND1, CLDN1, ROCK2, CTNNA2, CTNNA1, RASSF5",0.315154638355588,0.231361898752386,FALSE +"HCC15","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.68417,2.16,0.0111,1421,0.128,"ALDH2, ALDH3A2, ALDH7A1, ECHS1, EHHADH, ALDH9A1",1.95467702121334,0.892790030352132,TRUE +"HCC15","Input","KEGG_LONG_TERM_DEPRESSION",-0.26318,-0.804,0.683,8559,0.941,"RAF1, GNAO1, PLCB2, PLA2G12A, PRKCB, RYR1, PRKG1",0.165579296318467,0.0264103765727431,FALSE +"HCC15","Input","KEGG_LONG_TERM_POTENTIATION",-0.27297,-0.83,0.63,8559,0.923,"RAF1, PLCB2, PRKCB, GRIN1, CAMK4, EP300",0.200659450546418,0.0347982989740879,FALSE +"HCC15","Input","KEGG_LYSINE_DEGRADATION",-0.29447,-0.907,0.521,7341,0.935,"KMT5B, SETD7, AASS, ALDH1B1, NSD1, DOT1L, NSD3, PLOD3, GCDH, SETD2, SETDB2, PLOD1, PLOD2, SETMAR, NSD2",0.283162276700476,0.0291883891274822,FALSE +"HCC15","Input","KEGG_LYSOSOME",0.42822,1.36,0.117,1901,0.346,"AGA, SLC11A2, TCIRG1, CTSV, GLA, CLN3, FUCA1, AP1S3, SLC17A5, SORT1, LIPA, ATP6V0D1, LAPTM4A, CTSL, LGMN, CTSZ, HEXA, ATP6V0A1, AP1S2, GUSB, GALNS, CD63, ATP6V0A2, PPT2, CTSF, AP1M1, CLTC, CLTB, NAGLU, IGF2R, AP4M1, NAGPA, NPC2, ABCA2, AP1G1, AP4E1, GNS, MANBA, ACP2, ATP6AP1",0.931814138253838,0.460923901207223,FALSE +"HCC15","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.24266,0.766,0.735,1309,0.794,"MAPK13, IL1A, TGFBR2, EGFR, FLNB, HSPA1L, CD14, RELB, ARRB1, HSPA2, MOS, RRAS2, NFKB2, RPS6KA5, AKT1, DDIT3, CACNA1C, PPP5C, HSPA6, RRAS, CDC25B, RASGRP2, CHUK, MAPK8, JUN, GNG12, MAP2K6, FLNC, HSPA1A",0.133712660915805,0.100179497572904,FALSE +"HCC15","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.64114,2.03,0.0102,1549,0.159,"PDX1, PKLR",1.99139982823808,0.798602875679548,TRUE +"HCC15","Input","KEGG_MELANOGENESIS",-0.28721,-0.907,0.497,8294,0.935,"GSK3B, KITLG, TCF7L1, RAF1, GNAO1, PLCB2, PRKCB, WNT10A, WNT5A, MITF, EP300",0.303643611266668,0.0291883891274822,FALSE +"HCC15","Input","KEGG_MELANOMA",-0.45576,-1.41,0.123,7572,0.839,"CCND1, PIK3CD, PIK3CB, CDKN1A, FGFR1, HGF, E2F3, RAF1, PIK3R2, CDK4, PDGFRB, MDM2, AKT3, FGF13, FGF2, PIK3CG, MITF, FGF1, RB1, CDKN2A",0.910094888560602,0.0762380391712997,FALSE +"HCC15","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.66437,2.11,0.0128,781,0.14,"ALDH3A1, CYP2S1, AKR1C3, GSTM4, EPHX1, GSTM3, GSTM2, CYP3A7, AKR1C1, ALDH3B1",1.89279003035213,0.853871964321762,TRUE +"HCC15","Input","KEGG_MISMATCH_REPAIR",0.48924,1.55,0.0738,2364,0.279,"MSH6, MSH2, POLD1, PMS2, LIG1, MLH1, RFC1, MSH3, POLD3",1.13194363817696,0.554395796726402,FALSE +"HCC15","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.27939,-0.871,0.587,7525,0.89,"CAB39L, PIK3CD, PIK3CB, PDPK1, EIF4E, PIK3R2, AKT3, PIK3CG, VEGFA, EIF4EBP1",0.231361898752386,0.0506099933550872,FALSE +"HCC15","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.27514,0.865,0.561,710,0.683,"IFNGR1, SYK, ICAM2, TNFRSF10A, ULBP3, PIK3R3, MICB, ICAM1, RAET1L, ULBP2",0.251037138743839,0.165579296318467,FALSE +"HCC15","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.34275,1.06,0.301,1517,0.522,"LEPR, F2R, P2RX4, HCRTR1, NR3C1, TACR1",0.521433504406157,0.282329496997738,FALSE +"HCC15","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.19855,-0.604,0.94,7383,1,"YWHAB, MAP2K7, NFKB1, MAP3K5, PIK3CD, PIK3CB, RHOA, PDPK1, FOXO3, SOS1, GAB1, GSK3B, PLCG1, PLCG2, RAF1, PIK3R2, AKT3, MAGED1, PIK3CG, PRKCD, GRB2, CAMK4, ARHGDIB",0.0268721464003014,0,FALSE +"HCC15","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.52387,1.65,0.0495,1098,0.24,"NNMT, QPRT, NAMPT, NT5E, NNT, NT5C2",1.30539480106643,0.619788758288394,TRUE +"HCC15","Input","KEGG_NITROGEN_METABOLISM",-0.39534,-1.21,0.215,9360,0.795,"GLUL, CA8, CA2",0.667561540084395,0.0996328713435297,FALSE +"HCC15","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.33409,1.06,0.345,1220,0.522,"MAPK13, IL18, CXCL8, CCL13, CHUK, MAPK8, BIRC2, PYCARD, CASP5",0.462180904926726,0.282329496997738,FALSE +"HCC15","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.57268,1.78,0.0323,1970,0.288,"RAD50, PRKDC, NHEJ1, XRCC6, XRCC5, MRE11",1.4907974776689,0.540607512240769,FALSE +"HCC15","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.44561,-1.42,0.105,7572,0.913,"CCND1, PIK3CD, PIK3CB, PDPK1, FOXO3, SOS1, E2F3, PLCG1, PLCG2, RAF1, PIK3R2, PRKCB, CDK4, AKT3, PIK3CG, GRB2, STK4, RB1, FHIT, CDKN2A",0.978810700930062,0.039529222465701,FALSE +"HCC15","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.39566,-1.24,0.205,6513,0.814,"HDAC1, MAML1, NUMBL, CIR1, NCSTN, RBPJ, HDAC2, SNW1, DVL3, CTBP1, NCOR2, JAG1, CREBBP, NOTCH3, DTX3, EP300",0.688246138944246,0.0893755951107988,FALSE +"HCC15","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.46661,1.46,0.0869,2100,0.308,"CUL4B, DDB2, ERCC8, GTF2H3, ERCC2, GTF2H4, ERCC3, POLD1, GTF2H2, CDK7, LIG1, CCNH, DDB1, GTF2H1, RFC1, POLE4, ERCC4",1.06098022355133,0.511449283499556,FALSE +"HCC15","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.18783,-0.581,0.972,6759,1,"STT3B, B4GALT3, ALG11, FUT8, DPM3, ALG10, ALG10B, DAD1, MGAT3, MAN1A2, MAN1A1, ST6GAL1",0.0123337350737254,0,FALSE +"HCC15","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.35419,-1.1,0.3,8784,0.964,"PRKG1, PDE1C",0.522878745280338,0.0159229660971692,FALSE +"HCC15","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.26886,0.848,0.625,2649,0.699,"SHMT1, MTHFS, AMT, MTFMT, ATIC, GART",0.204119982655925,0.155522824254319,FALSE +"HCC15","Input","KEGG_OOCYTE_MEIOSIS",0.26817,0.821,0.678,2127,0.725,"ITPR3, MOS, ADCY9, ADCY5, AR, CCNB1, ITPR2, ADCY6, PPP2R5D, CDC27, IGF1R, YWHAZ, CDC23, ANAPC7, PRKACB, ANAPC4, CDC16, PPP3CC, ITPR1, ANAPC2, ESPL1",0.168770306132937,0.139661993429006,FALSE +"HCC15","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.56931,1.79,0.0259,743,0.303,"AGA, FUCA2, FUCA1, MAN2B2, HEXA",1.58670023591875,0.518557371497695,FALSE +"HCC15","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.1544,-0.483,1,6739,0.997,"ATP5PD, NDUFV2, ATP6V1D, ATP5MG, NDUFA7, COX7A2L, NDUFAB1, NDUFS6, COX6C, NDUFA6, COX11, NDUFS5, ATP6V1F, PPA2, ATP5ME, UQCRC2, NDUFS4, UQCR10, COX17, ATP6V1G1, ATP6V1E1, UQCRB, UQCRFS1, UQCRQ",0,0.00130484168834428,FALSE +"HCC15","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.45865,1.45,0.107,1429,0.3,"ST3GAL1, GALNT5, C1GALT1, GALNT13, GALNT15, GALNT7, B3GNT6, C1GALT1C1",0.97061622231479,0.522878745280338,FALSE +"HCC15","Input","KEGG_P53_SIGNALING_PATHWAY",-0.24114,-0.749,0.769,6416,1,"TNFRSF10B, TP53I3, CASP3, CYCS, CHEK1, GTSE1, COP1, PPM1D, SERPINE1, CD82, CCND1, CDKN1A, THBS1, RCHY1, CHEK2, CCND2, CDK4, MDM2, IGFBP3, CDKN2A",0.114073660198569,0,FALSE +"HCC15","Input","KEGG_PANCREATIC_CANCER",-0.28514,-0.887,0.559,8553,0.962,"ARHGEF6, RAF1, RAC2, PIK3R2, CDK4, AKT3, SMAD4, PIK3CG, RAC3, VEGFA, RB1, CDKN2A",0.252588192113577,0.0168249279621871,FALSE +"HCC15","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.54978,1.7,0.054,1555,0.243,"BCAT1, BCAT2, PPCS, COASY",1.26760624017703,0.614393726401688,FALSE +"HCC15","Input","KEGG_PARKINSONS_DISEASE",-0.16333,-0.493,0.994,8189,1,"PPID, UQCRC2, NDUFS4, UQCR10, UBE2L3, UBE2G1, UQCRB, UQCRFS1, UQCRQ, SNCA",0.00261361560268669,0,FALSE +"HCC15","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.34997,1.11,0.304,729,0.489,"TUBB2B, OCLN, CDH1, CD14, CTNNB1, ARPC1A, CLDN1, ROCK2",0.517126416391246,0.31069114087638,FALSE +"HCC15","Input","KEGG_PATHWAYS_IN_CANCER",-0.27189,-0.843,0.619,7526,0.934,"NFKB1, BCR, DVL3, CCND1, PIK3CD, PIK3CB, CDKN1A, RHOA, CTBP1, FGFR1, LAMB2, CDKN1B, BIRC5, HGF, SOS1, ARNT, CREBBP, MECOM, FOXO1, PIAS1, RUNX1, CKS1B, LAMC1, GSK3B, E2F3, KITLG, TCF7L1, PLCG1, PLCG2, PIAS4, RAF1, RAC2, PIK3R2, PRKCB, RUNX1T1, CDK4, PDGFRB, MDM2, PIAS2, CEBPA, IL6, AKT3, SKP2, WNT10A, SMAD4, WNT5A, FN1, PAX8, FGF13, FGF2, PIK3CG, MMP2, CBLB, GRB2, RAC3, VEGFA, MAX, STK4, LAMB1, SPI1, COL4A2, MITF, FGF1, RB1, EP300, CDKN2A",0.208309350979882,0.0296531237699066,FALSE +"HCC15","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.42385,1.35,0.126,973,0.341,"UGDH, GUSB",0.899629454882437,0.467245621007502,FALSE +"HCC15","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.31498,1.01,0.394,505,0.552,"PFKP, TALDO1, RBKS, G6PD",0.404503778174426,0.258060922270801,FALSE +"HCC15","Input","KEGG_PEROXISOME",0.53609,1.67,0.0353,2653,0.244,"SLC27A2, ABCD1, PECR, DECR2, ACSL3, PEX16, AMACR, NUDT19, PEX3, CROT, MPV17, EHHADH, ACSL1, PXMP4, AGPS, PEX1, GNPAT, PEX6, FAR1, PEX10, PRDX1, SCP2, GSTK1, PEX11B, SLC25A17, ECI2, PEX13, ACOX1, DHRS4, ACSL6, ABCD3, PHYH, CAT, CRAT",1.45222529461218,0.612610173661271,TRUE +"HCC15","Input","KEGG_PHENYLALANINE_METABOLISM",0.55262,1.75,0.0313,1123,0.241,"ALDH3A1, MAOA, ALDH3B1, GOT1",1.50445566245355,0.617982957425132,TRUE +"HCC15","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.28458,-0.875,0.574,7590,0.922,"PIK3CD, PI4KB, PIK3CB, DGKD, INPP5B, CDS1, PLCG1, DGKH, PLCG2, PIP4K2A, PIK3R2, IMPA2, PLCB2, PRKCB, INPP4B, PIK3CG, PLCZ1, INPP5D",0.241088107602027,0.0352690789463706,FALSE +"HCC15","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.45006,1.41,0.121,2433,0.316,"BLVRB, BLVRA, ALAS1, HMOX2, GUSB, HMBS, COX15, PPOX, EARS2, FECH, FTH1",0.91721462968355,0.500312917381596,FALSE +"HCC15","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.30026,-0.927,0.51,8886,0.962,"SCD, APOC3, ACSL4, LPL, FADS2, PLTP, SCD5",0.292429823902064,0.0168249279621871,FALSE +"HCC15","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.60596,-1.9,0.0189,8612,0.611,"BTK, RFX5, CD79A, RFXANK, PTPRC, RFXAP, TNFRSF13C",1.72353819582676,0.213958789757446,FALSE +"HCC15","Input","KEGG_PRION_DISEASES",0.28477,0.883,0.552,561,0.674,"IL1A, C9",0.258060922270801,0.17134010346468,FALSE +"HCC15","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.37195,1.18,0.208,2398,0.44,"MAPK13, FZR1, PIK3R3, MOS, GNAI1, ADCY9, AKT1, ADCY5, CDC25B, MAPK8, CCNB1, ADCY6, CDC27, IGF1R, CDC23, ANAPC7, PRKACB, ANAPC4, CDC16, GNAI3, MAPK9, ANAPC2, AKT2, MAPK10, PKMYT1, HSP90AB1",0.681936665037238,0.356547323513813,FALSE +"HCC15","Input","KEGG_PROPANOATE_METABOLISM",0.41893,1.28,0.17,1421,0.367,"ALDH2, MCEE, ACACA, ALDH3A2, ACACB, ALDH7A1, ECHS1, EHHADH, LDHA, ACSS2, ALDH9A1",0.769551078621726,0.435333935747911,FALSE +"HCC15","Input","KEGG_PROSTATE_CANCER",-0.37041,-1.16,0.252,7418,0.883,"HSP90B1, NFKB1, CCND1, PIK3CD, CREB1, PIK3CB, CDKN1A, PDPK1, FGFR1, CDKN1B, SOS1, CREBBP, FOXO1, GSK3B, E2F3, TCF7L1, RAF1, PIK3R2, PDGFRB, MDM2, AKT3, PIK3CG, GRB2, RB1, EP300",0.598599459218456,0.0540392964224314,FALSE +"HCC15","Input","KEGG_PROTEASOME",0.30995,1,0.395,3713,0.554,"PSMB8, PSME2, PSME1, PSMD1, PSMD3, PSMD12, PSMD11, PSME4, PSMB2, PSMD6, PSMA6, PSMB1, PSMB5, PSMB4, PSMA4, PSMD13, PSMC3, PSMA2, PSMC5, PSMC4, PSMD2, PSMA7, PSMA3, PSMC2, PSMA5",0.40340290437354,0.25649023527157,FALSE +"HCC15","Input","KEGG_PROTEIN_EXPORT",0.2489,0.766,0.74,2587,0.794,"SEC63, SEC11A, SRPRA, SPCS2, SRP68, SRP14, SRP72, SRP54",0.130768280269024,0.100179497572904,FALSE +"HCC15","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.40714,-1.24,0.198,8380,0.814,"ATP1B3, SLC4A4, SLC38A3, CA2",0.703334809738469,0.0893755951107988,FALSE +"HCC15","Input","KEGG_PURINE_METABOLISM",-0.17481,-0.554,0.992,6682,1,"AMPD2, APRT, PAICS, NPR2, POLD4, POLR2E, NT5C, NUDT9, PNP, POLR2L, GMPS, ITPA, NUDT2, PRPS2, PDE3B, POLR2C, PDE5A, IMPDH1, PRUNE1, POLR2G, ENTPD6, POLR2J, CANT1, NT5C3A, POLR2I, POLR2K, DCK, POLR2H, POLR3G, PDE1C, IMPDH2, POLR2F, FHIT, PDE2A",0.00348832784582135,0,FALSE +"HCC15","Input","KEGG_PYRIMIDINE_METABOLISM",-0.19577,-0.604,0.953,6792,1,"POLD4, POLR2E, NT5C, PNP, POLR2L, UCKL1, ITPA, NUDT2, POLR2C, POLR2G, UPRT, ENTPD6, POLR2J, CANT1, NT5C3A, POLR2I, TYMS, POLR2K, DCK, POLR2H, UCK2, POLR3G, POLR2F, TXNRD2",0.0209070993616736,0,FALSE +"HCC15","Input","KEGG_PYRUVATE_METABOLISM",0.53627,1.67,0.0438,1549,0.244,"ME1, ME3, GLO1, ALDH2, PC, ACACA, ALDH3A2, ACACB, ALDH7A1, DLAT, LDHA, ACSS2, ALDH9A1, PKLR",1.3585258894959,0.612610173661271,TRUE +"HCC15","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.24873,0.77,0.742,612,0.803,"ITGA1, IQGAP2, EGFR, ITGB5, CFL2, ACTN4, ITGB4, CD14, ITGA6, PIK3R3, ITGA3, IQGAP1, ITGA2, RDX, F2R, MOS, RRAS2, ARPC1A, GNA13",0.129596094720973,0.095284454721319,FALSE +"HCC15","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.18543,-0.564,0.985,6494,1,"PIK3C3, PIK3R4, GABARAPL2, ATG4B, ATG3",0.00656376950238827,0,FALSE +"HCC15","Input","KEGG_RENAL_CELL_CARCINOMA",-0.28262,-0.877,0.575,7590,0.939,"PIK3CD, PIK3CB, HGF, SOS1, ARNT, CREBBP, PAK3, PAK1, GAB1, RAF1, PIK3R2, AKT3, PIK3CG, GRB2, VEGFA, EP300",0.24033215531037,0.0273344077338891,FALSE +"HCC15","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.66735,-2.06,0.00748,7871,0.556,"CTSG, ACE, MME, ANPEP, CPA3, CTSA",2.12609840213554,0.254925208417942,FALSE +"HCC15","Input","KEGG_RETINOL_METABOLISM",0.4217,1.31,0.161,715,0.37,"CYP3A7, RETSAT, ALDH1A1",0.79317412396815,0.431798275933005,FALSE +"HCC15","Input","KEGG_RIBOFLAVIN_METABOLISM",0.41018,1.28,0.173,2858,0.367,"RFK, ACP2, FLAD1, MTMR2",0.761953896871205,0.435333935747911,FALSE +"HCC15","Input","KEGG_RIBOSOME",0.513,1.65,0.039,2751,0.24,"RPL26L1, RPL37, RPL19, RPS4Y1, RPL34, RPS6, RPL15, RPL36A, RPL36AL, RPL26, RPS13, RPL37A, RPS11, RPL24, RSL24D1, RPL27A, RPS18, RPL7, RPL35, RPL36, RPS24, RPL13A, RPS7, RPS16, RPS26, RPL6, RPL18A, RPL27, RPL18, RPS8, FAU, RPL3, RPS3A, RPL21, RPS2, RPL32, RPL9, RPL8, RPL10A, RPL28, RPS10, RPS3, RPL35A, RPS9, RPS15A, RPS23, RPL29, RPL5, RPL4, RPS20, RPL14, RPS4X, RPL38, RPL31, RPL23A, RPL7A",1.4089353929735,0.619788758288394,TRUE +"HCC15","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.44128,1.36,0.13,3008,0.346,"MAPK13, IFIH1, ISG15, CXCL8, DDX58, NLRX1, CHUK, MAPK8, CYLD, MAPK9, NFKBIB, RIPK1, MAPK10, ATG5, CASP8, TANK, TRAF2, PIN1, IRF3, RELA, TRADD, CXCL10, CASP10, TKFC, DDX3X",0.886056647693163,0.460923901207223,FALSE +"HCC15","Input","KEGG_RNA_DEGRADATION",-0.18615,-0.578,0.98,5585,1,"CNOT8, EXOSC4, CNOT9, EXOSC6, LSM3, PAPOLG, CNOT6, CNOT2, XRN1, EDC3, CNOT3, ZCCHC7, LSM7, CNOT4, LSM8, MPHOSPH6, LSM2, LSM4, DCP1A, LSM6, DCP1B, LSM1, C1D, LSM5",0.00877392430750515,0,FALSE +"HCC15","Input","KEGG_RNA_POLYMERASE",-0.49911,-1.54,0.0702,5378,0.981,"POLR1B, POLR2B, POLR3K, POLR3D, POLR3F, POLR1C, POLR1D, POLR2D, POLR3H, POLR2E, POLR2L, POLR2C, POLR2G, POLR2J, POLR2I, POLR2K, POLR2H, POLR3G, POLR2F",1.15366288787019,0.0083309926200515,FALSE +"HCC15","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.46946,1.44,0.101,587,0.302,"GGT1, PAPSS2, MAT1A, CBS",0.995678626217357,0.519993057042849,FALSE +"HCC15","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.31449,-0.96,0.487,7083,0.931,"LAMA1, LAMA5, LAMA3, LAMA4, TRAF4, NFKB1, CCND1, PIK3CD, PIK3CB, LAMB2, CDKN1B, PIAS1, CKS1B, LAMC1, E2F3, PIAS4, PIK3R2, CDK4, PIAS2, AKT3, SKP2, FN1, PIK3CG, MAX, LAMB1, COL4A2, RB1, FHIT",0.312471038785366,0.0310503190186574,FALSE +"HCC15","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.52043,1.62,0.0598,1679,0.255,"STX3, VAMP7, VAMP8, STX5, VTI1A, VAMP2, STX12, VAMP3, STX4, STX7, BET1, YKT6, SNAP23, GOSR1",1.22329881601159,0.593459819566045,FALSE +"HCC15","Input","KEGG_SPHINGOLIPID_METABOLISM",0.47522,1.5,0.0896,482,0.307,"PLPP2, UGCG, GLA, SGPL1, PLPP3",1.04769199033787,0.512861624522813,FALSE +"HCC15","Input","KEGG_SPLICEOSOME",-0.24176,-0.734,0.774,5674,0.992,"SRSF4, MAGOHB, SRSF9, DDX5, ALYREF, DHX8, THOC3, NCBP2, SF3B4, SNRNP40, HNRNPM, SF3A1, LSM3, PPIH, PPIE, HNRNPA1, SLU7, SF3B5, SNU13, SRSF2, PCBP1, U2SURP, HNRNPA3, PRPF4, TXNL4A, SRSF10, SF3B6, SRSF5, LSM7, HNRNPC, SNRPC, SRSF3, CCDC12, SF3A2, SMNDC1, SNW1, RBM8A, LSM8, SNRPA1, SART1, LSM2, SRSF1, LSM4, PRPF18, LSM6, RBM17, SF3B2, SNRPB, ZMAT2, SNRPG, CWC15, PHF5A, ISY1, PRPF40B, SYF2, LSM5",0.111259039317107,0.00348832784582135,FALSE +"HCC15","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.41088,1.29,0.157,973,0.37,"PGM2L1, UGDH, GUSB",0.804100347590766,0.431798275933005,FALSE +"HCC15","Input","KEGG_STEROID_BIOSYNTHESIS",-0.41751,-1.28,0.177,8601,0.956,"SQLE, MSMO1, FDFT1, CYP51A1",0.752026733638193,0.0195421077238999,FALSE +"HCC15","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.50366,1.58,0.0605,560,0.283,"AKR1C3, CYP21A2, CYP3A7, AKR1C1",1.21824462534753,0.54821356447571,FALSE +"HCC15","Input","KEGG_SULFUR_METABOLISM",0.87387,2.74,0,234,0.004,"SULT1A3, PAPSS2, SULT1A1",Inf,2.39794000867204,TRUE +"HCC15","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.30277,-0.945,0.478,7662,0.943,"C3, CTSG, SNRPB, ACTN3, ELANE, C4A, FCGR2B, FCGR2C",0.320572103387881,0.0254883072626717,FALSE +"HCC15","Input","KEGG_TASTE_TRANSDUCTION",0.45887,1.45,0.0789,1816,0.3,"ITPR3, ADCY6, PRKACB, KCNB1",1.10292299679058,0.522878745280338,FALSE +"HCC15","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.24242,-0.751,0.781,7277,1,"HMGCR, PMVK, HMGCS1",0.1073489661227,0,FALSE +"HCC15","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.33064,-1.04,0.355,8504,0.935,"E2F4, SP1, AMH, SMAD4, ID3, E2F5, TFDP1, LTBP1, THBS3, DCN, EP300",0.449771646944906,0.0291883891274822,FALSE +"HCC15","Input","KEGG_THYROID_CANCER",0.21511,0.683,0.877,567,0.901,"CDH1, CTNNB1",0.0570004066339595,0.045275209020937,FALSE +"HCC15","Input","KEGG_TIGHT_JUNCTION",0.30445,0.967,0.44,888,0.575,"CLDN6, TJP1, OCLN, ACTN4, TJP2, EPB41L3, GNAI1, RRAS2, CTNNB1, SPTAN1, AKT1, CLDN1, CTNNA2, CTNNA1, LLGL2, RRAS",0.356547323513813,0.24033215531037,FALSE +"HCC15","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.31747,0.982,0.409,1198,0.57,"MAPK13, CXCL8, CD40, CD14, PIK3R3, STAT1, AKT1, CHUK, MAPK8, JUN, MAP2K6",0.388276691992658,0.244125144327509,FALSE +"HCC15","Input","KEGG_TRYPTOPHAN_METABOLISM",0.59759,1.88,0.0215,1016,0.263,"KYNU, ALDH2, MAOA, OGDH, ALDH3A2, ALDH7A1, ECHS1, OGDHL, EHHADH",1.66756154008439,0.580044251510242,FALSE +"HCC15","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.2252,0.707,0.855,1012,0.874,"PIK3R3, IRS1, CACNA1C, PDX1, MAPK8",0.0680338852718274,0.058488567365597,FALSE +"HCC15","Input","KEGG_TYPE_I_DIABETES_MELLITUS",-0.56543,-1.74,0.0321,9482,0.576,"CPE, ICA1",1.49349496759513,0.239577516576788,FALSE +"HCC15","Input","KEGG_TYROSINE_METABOLISM",0.42033,1.33,0.143,1123,0.356,"ALDH3A1, FAH, MAOA, ALDH3B1, GOT1",0.844663962534938,0.448550002027125,FALSE +"HCC15","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.31141,-0.967,0.438,7470,0.941,"MAP2K7, NFKB1, PIK3CD, PIK3CB, RHOA, PDPK1, NFATC4, SOS1, NCK2, LCP2, PAK3, PRKCQ, PAK1, NFATC1, GSK3B, PLCG1, RAF1, PIK3R2, CDK4, AKT3, VAV3, NFATC2, PIK3CG, GRAP2, NCK1, CBLB, GRB2, PTPRC",0.3585258894959,0.0264103765727431,FALSE +"HCC15","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.1932,0.603,0.961,2072,0.967,"MID1, SMURF1, FZR1, PML, CUL4B, SMURF2, DDB2, ERCC8, WWP2, WWP1, BIRC2, NEDD4, CDC27, UBE4A, UBE2H, STUB1, CDC23, ITCH, ANAPC7, ANAPC4, CDC16, SAE1, DDB1, CUL5, ANAPC2, HUWE1, UBE3B",0.0172766123314547,0.0145735259169983,FALSE +"HCC15","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.74502,2.37,0.00222,518,0.056,"BCAT1, BCAT2, IARS2",2.65364702554936,1.2518119729938,TRUE +"HCC15","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.37736,1.2,0.22,1150,0.422,"ALDH2, BCAT1, BCAT2, ACADS, MCEE, ACADSB, ALDH3A2, ALDH7A1, HADHB, ECHS1, EHHADH, AUH",0.657577319177794,0.374687549038326,FALSE +"HCC15","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.29982,0.937,0.495,1432,0.598,"KCNMA1, ITPR3, ADCY9, GNA13, ADCY5, ROCK2, CACNA1C, ARHGEF11, CALD1, NPR1, ITPR2, ADCY6, ARHGEF1, MYH11",0.305394801066431,0.223298816011589,FALSE +"HCC15","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.35858,1.15,0.271,2349,0.454,"ADCY9, DYNC1LI2, RAB11A, VAMP2, DYNC1H1, RAB5C, STX4, RAB5A, ADCY6, PRKACB, DYNLL2, RAB5B, DCTN1, NSF, DYNC1I1",0.567030709125594,0.342944147142896,FALSE +"HCC15","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.32366,-1.03,0.388,7590,0.894,"PIK3CD, PIK3CB, SH2D2A, NFATC4, NFATC1, PLCG1, PLCG2, RAF1, RAC2, PIK3R2, PLA2G12A, PRKCB, HSPB1, AKT3, NFATC2, PIK3CG, RAC3, VEGFA",0.411168274405793,0.0486624812040823,FALSE +"HCC15","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.43625,1.36,0.126,1019,0.346,"TJP1, TCIRG1, TJP2, ERO1A, SLC12A2, ATP6V0D1, ADCY9, ATP6V0A1, KDELR3, ATP6V0A2",0.899629454882437,0.460923901207223,FALSE +"HCC15","Input","KEGG_VIRAL_MYOCARDITIS",0.27096,0.84,0.595,519,0.699,"CD40, DMD, CXADR, ICAM1",0.22548303427145,0.155522824254319,FALSE +"HCC15","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.24023,-0.747,0.782,7533,0.985,"DVL3, CCND1, SFRP1, ROCK1, RHOA, CTBP1, PPP2R5E, NFATC4, LRP6, CREBBP, SENP2, NFATC1, GSK3B, TCF7L1, CCND2, RAC2, LRP5, PLCB2, PRKCB, WNT10A, SMAD4, WNT5A, CHD8, NFATC2, RAC3, VANGL2, TBL1XR1, EP300",0.106793246940152,0.00656376950238827,FALSE +"HCC44","Input","KEGG_ABC_TRANSPORTERS",0.27486,0.843,0.625,1943,0.789,"ABCC3, TAP2, ABCG1, ABCA1, ABCD4, ABCG2, ABCC4, ABCA3, TAP1",0.204119982655925,0.10292299679058,FALSE +"HCC44","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.36325,-1.08,0.31,7099,0.661,"PIK3CA, RAF1, AKT2, MAPK1, TCF7L2, TCF7L1, MAPK3, CCND1, GRB2, BAD, SOS1, PIK3CD, EIF4EBP1, KIT, LEF1",0.508638306165727,0.17979854051436,FALSE +"HCC44","Input","KEGG_ADHERENS_JUNCTION",-0.36307,-1.06,0.333,7376,0.624,"MAPK1, SSX2IP, TCF7L2, TCF7L1, MAPK3, ERBB2, CDH1, PTPN6, CTNNA2, CTNNA1, CTNND1, SRC, CTNNB1, WASF3, FARP2, RAC3, NECTIN4, FGFR1, PTPRF, NECTIN1, LEF1",0.47755576649368,0.204815410317576,FALSE +"HCC44","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.36766,-1.09,0.31,7212,0.655,"PRKCQ, AKT2, CAMKK2, RXRA, PRKAA1, NFKBIE, PRKAG1, RXRG, CD36, ADIPOR1, ACSL1, ACSL6",0.508638306165727,0.183758700008217,FALSE +"HCC44","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.59494,-1.68,0.0528,8712,0.42,"GLUL, ABAT, ALDH5A1, GLUD2",1.27736607746619,0.3767507096021,FALSE +"HCC44","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.34789,-1.03,0.371,6325,0.595,"ATP1B1, PIK3R1, PIK3R2, IRS1, ATP1A4, INSR, ATP1A1, ATP1A3, PIK3CA, MAPK1, MAPK3, PDPK1, SCNN1A, PIK3CD, HSD11B2",0.430626090384954,0.22548303427145,FALSE +"HCC44","Input","KEGG_ALZHEIMERS_DISEASE",-0.3673,-1.07,0.318,7130,0.641,"GNAQ, FAS, PPP3CC, COX5A, ATP5PF, PLCB3, CASP9, MAPK1, MAPK3, CDK5, APP, CASP8, MME, NCSTN, GRIN1, FADD, APH1A, CAPN1, BAD, ATP2A3, APOE, GSK3B, MAPT, CALM2, LPL, NDUFA4, CALML3, PPP3R1, PLCB4, APBB1, SNCA, BACE1",0.497572880015567,0.193141970481183,FALSE +"HCC44","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.27894,0.869,0.598,2386,0.789,"RARS2, WARS2, FARS2, MARS2, MTFMT, LARS2",0.223298816011589,0.10292299679058,FALSE +"HCC44","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.28436,0.865,0.57,2234,0.77,"GFPT2, GNPNAT1, GCK, GALE, UGDH, UXS1, PGM3, GMDS, HEXA, NANS",0.244125144327509,0.113509274827518,FALSE +"HCC44","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.26042,0.793,0.686,272,0.823,"PRPH, PRPH2, NEFH, NEFM",0.163675884293248,0.0846001647877302,FALSE +"HCC44","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.5863,1.81,0.0209,1943,0.549,"CD74, CTSS, RFXAP, TAPBP, B2M, RFX5, IFI30, CTSB, TAP2, PSME1, PSME2, PSME3, LGMN, HSPA5, CALR, TAP1",1.67985371388895,0.260427655549908,FALSE +"HCC44","Input","KEGG_APOPTOSIS",-0.21172,-0.617,0.924,7099,0.976,"PIK3CA, IL1RAP, FAS, PPP3CC, AKT2, CASP9, CASP8, ENDOD1, FADD, CASP6, CAPN1, PRKAR2B, BAD, PIK3CD, BCL2, PPP3R1, TP53",0.0343280287798933,0.0105501823333082,FALSE +"HCC44","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.63466,1.98,0.00554,99,0.545,"PTGES, PTGS2, PLA2G4A, GGT1",2.25649023527157,0.263603497723358,FALSE +"HCC44","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.3632,-1.07,0.344,8510,0.641,"GATM, GLUL, CKMT1A, GLUD2",0.46344155742847,0.193141970481183,FALSE +"HCC44","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.46641,-1.36,0.134,8197,0.554,"CTNNA2, CTNNA1, DAG1, SGCB, ITGB6, CTNNB1, PKP2, ITGA6, ITGA11, SGCG, DSC2, CACNA2D1, ITGA4, LEF1, CDH2, ITGB8",0.872895201635192,0.25649023527157,FALSE +"HCC44","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.56049,1.74,0.0537,2844,0.401,"ALDH2, ALDH1B1, UGDH, ALDH3A2, ALDH7A1",1.27002571430044,0.396855627379818,FALSE +"HCC44","Input","KEGG_AXON_GUIDANCE",-0.44133,-1.28,0.178,7185,0.617,"EPHA5, LIMK2, PPP3CC, EFNA5, EPHB1, PAK4, SEMA4C, DPYSL2, MAPK1, NTN4, ARHGEF12, MAPK3, CDK5, L1CAM, EPHA1, DPYSL5, EPHA7, EPHB4, EFNB1, EFNA1, SEMA3C, PLXNA3, PLXNA2, ROBO1, NCK2, PAK5, PAK6, GSK3B, RAC3, EPHB3, PLXNB3, PPP3R1, SEMA4D, EPHA4, EPHA3, SEMA6D, SEMA5A",0.749579997691106,0.209714835966758,FALSE +"HCC44","Input","KEGG_BASAL_CELL_CARCINOMA",-0.46082,-1.37,0.131,6849,0.559,"APC, WNT5A, FZD1, SUFU, WNT11, TCF7L2, TCF7L1, FZD6, CTNNB1, GSK3B, TP53, LEF1",0.882728704344236,0.252588192113577,FALSE +"HCC44","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.60458,1.88,0.0169,2061,0.552,"TAF12, GTF2F1, GTF2F2, GTF2E2, GTF2H2, TAF11, GTF2A2, GTF2E1, TBP, GTF2H1, GTF2H3, TAF9, TAF10, GTF2H4, GTF2B",1.77211329538633,0.258060922270801,FALSE +"HCC44","Input","KEGG_BASE_EXCISION_REPAIR",0.16293,0.492,0.998,1419,1,"PARP2, HMGB1, MBD4, NTHL1",0.000869458712628891,0,FALSE +"HCC44","Input","KEGG_BETA_ALANINE_METABOLISM",0.23723,0.716,0.81,1312,0.909,"ALDH2, EHHADH, MLYCD, ALDH1B1",0.0915149811213502,0.0414361167780325,FALSE +"HCC44","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.31543,0.945,0.473,1391,0.749,"ELOVL5, ACOT2, ACOT1, HACD2, YOD1, ACOT7",0.325138859262188,0.125518182300534,FALSE +"HCC44","Input","KEGG_BLADDER_CANCER",0.3647,1.13,0.263,170,0.658,"MYC, MMP1, CDKN2A, VEGFA",0.580044251510242,0.181774106386044,FALSE +"HCC44","Input","KEGG_BUTANOATE_METABOLISM",-0.36396,-1.07,0.339,8659,0.641,"ACADS, ABAT, ALDH5A1, HMGCS1",0.469800301796918,0.193141970481183,FALSE +"HCC44","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.38816,-1.12,0.282,7081,0.651,"NFATC2, PIK3CA, RAF1, PPP3CC, AKT2, MAPK1, VAV2, MAPK3, BTK, NFKBIE, GRB2, PTPN6, SOS1, VAV3, GSK3B, PIK3CD, SYK, PIK3AP1, CD81, RAC3, PLCG2, PPP3R1",0.549750891680639,0.186419011431808,FALSE +"HCC44","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.33855,-1,0.425,6461,0.641,"ATP2B2, ATP2B4, VDAC3, TACR1, ATP2A1, PHKA2, PLCB1, SLC25A4, NOS1, SLC8A1, PLCB2, GNAQ, P2RX7, PPP3CC, CAMK2B, ADCY9, PLCB3, ITPKB, GNA11, CAMK2D, ERBB2, GRIN1, PLCG1, PLCD1, ATP2A3, CALM2, ERBB3, PLCG2, CALML3, PPP3R1, PLCB4",0.371611069949688,0.193141970481183,FALSE +"HCC44","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.38684,-1.14,0.273,6095,0.657,"COX6B1, CYC1, CACNA1F, ATP1B1, UQCRFS1, COX5B, ATP1A4, TPM4, UQCRQ, MYH7, SLC8A1, ATP1A1, ATP1A3, COX5A, TPM1, TPM3, SLC9A1, CACNA2D1",0.563837352959244,0.182434630440219,FALSE +"HCC44","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.56324,-1.65,0.0505,8461,0.43,"PTPRC, CD99, NRCAM, SDC1, CDH15, CDH3, CD276, ITGA6, VCAN, SDC4, ITGA4, PTPRF, NCAM1, NECTIN1, CADM1, SDC2, CDH4, CDH2, ITGB8, JAM3, CNTNAP2",1.29670862188134,0.366531544420413,FALSE +"HCC44","Input","KEGG_CELL_CYCLE",-0.24385,-0.712,0.823,6921,0.93,"CDC25C, WEE1, CDC45, CDKN1A, CREBBP, CDK2, BUB1B, PLK1, PTTG1, SKP1, YWHAB, CCND1, ANAPC4, CCNB3, CCNA2, CCNB2, TTK, YWHAZ, FZR1, CDC20, BUB1, CHEK1, CCNB1, GSK3B, CDK1, RB1, PKMYT1, TP53",0.0846001647877302,0.0315170514460649,FALSE +"HCC44","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.28983,-0.859,0.626,7044,0.797,"PLCB2, GNG4, PIK3CA, RAF1, AKT2, ADCY9, PLCB3, MAPK1, TIAM2, CCL13, VAV2, MAPK3, GRK2, ARRB2, ARRB1, GRB2, PRKCD, STAT1, CCL14, STAT2, GSK3A, SOS1, VAV3, GRK5, CSK, GSK3B, PIK3CD, PREX1, GRK6, PRKCZ, PLCB4",0.20342566678957,0.0985416786038876,FALSE +"HCC44","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.28494,0.881,0.59,268,0.777,"MYC, TGFB1, CDKN2A, TGFB2, MECOM",0.229147988357856,0.109578981199086,FALSE +"HCC44","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.2745,0.837,0.588,1541,0.788,"SDHA, ACLY, PCK2, SDHD, SDHC, DLST",0.230622673923862,0.103473782510445,FALSE +"HCC44","Input","KEGG_COLORECTAL_CANCER",0.30816,0.93,0.511,181,0.765,"RAC2, MYC, JUN, TGFB1, TGFB2",0.291579099865287,0.116338564846382,FALSE +"HCC44","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.37428,1.16,0.278,399,0.66,"CFB, THBD, PLAUR, SERPINE1, C3, MBL2, PLAU, F8",0.555955204081924,0.180456064458131,FALSE +"HCC44","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.37767,1.14,0.259,2642,0.658,"CTH, BHMT, CBS, AHCYL1, MAT2B, GOT2, MPST, AHCYL2, MAT1A, SDS, MAT2A, MTAP",0.586700235918748,0.181774106386044,FALSE +"HCC44","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33436,1.03,0.381,546,0.65,"CXCL5, CD40, TGFB1, TNFRSF10B, VEGFA, TGFB2, BMPR2, EPO, CSF1",0.419075024324381,0.187086643357144,FALSE +"HCC44","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.26539,0.821,0.628,1093,0.806,"NFKB1, IRF3, PYCARD, POLR3G, CASP1",0.202040356262804,0.0936649581949093,FALSE +"HCC44","Input","KEGG_DILATED_CARDIOMYOPATHY",0.29172,0.902,0.525,846,0.764,"DES, TGFB1, TGFB2, ITGA1, ITGA2, LAMA2, ITGA3, ITGB3, ITGB1, GNAS, ITGA5",0.279840696594043,0.11690664142431,FALSE +"HCC44","Input","KEGG_DNA_REPLICATION",0.23591,0.701,0.827,4125,0.92,"RNASEH2A, SSBP1, RNASEH2B, RFC1, RFC3, RPA1, MCM3, POLD3, MCM6, MCM2, MCM5, RPA2, POLD1, RFC4, RFC2, MCM7, POLD2, MCM4, RPA3, POLE3, RNASEH1, RFC5",0.0824944904474534,0.0362121726544447,FALSE +"HCC44","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.43405,-1.27,0.187,7376,0.614,"MAPK1, MAPK3, GRB2, SOS1, NOTCH3",0.728158393463501,0.211831628858832,FALSE +"HCC44","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.54485,-1.6,0.0457,7126,0.407,"GSTM3, GSTT2, ALDH3A1, MAOB, MAOA, MGST2, ADH4, ADH7, MGST3, GSTM1, ADH5, GSTP1, GSTM4",1.34008379993015,0.39040559077478,FALSE +"HCC44","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.45365,1.38,0.116,1597,0.435,"CDA, UPP1, TYMP, NAT2, GMPS, HPRT1, GUSB, NAT1, TPMT",0.935542010773082,0.361510743045363,FALSE +"HCC44","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.38056,-1.13,0.292,7550,0.647,"SPP1, LAMA3, LAMA4, HMMR, ITGB4, TNXB, CD36, COL1A2, DAG1, VTN, ITGB6, SDC1, ITGA6, FN1, COL1A1, ITGA11, COL3A1, SDC4, ITGA4, SDC2, THBS1, SV2B, ITGB8",0.534617148551582,0.1890957193313,FALSE +"HCC44","Input","KEGG_ENDOCYTOSIS",-0.29762,-0.889,0.544,6737,0.762,"CHMP5, HSPA1A, EPS15, TSG101, VPS4B, EHD2, CHMP2A, CHMP2B, ARFGAP2, VPS37C, VPS4A, VPS37A, RNF41, STAM2, RAB11FIP1, GRK2, ARRB2, ARRB1, DAB2, IQSEC2, RAB5B, SMAP1, GIT1, SH3GLB2, ASAP1, RAB11A, SMURF2, HSPA2, AGAP1, RAB4A, PARD6G, SRC, HSPA1L, GRK5, EPN3, ASAP3, ERBB3, GRK6, KIT, PRKCZ, SH3GL2, MVB12B",0.26440110030182,0.1180450286604,FALSE +"HCC44","Input","KEGG_ENDOMETRIAL_CANCER",-0.48139,-1.44,0.0811,7099,0.595,"PIK3CA, RAF1, AKT2, CASP9, MAPK1, TCF7L2, TCF7L1, MAPK3, CCND1, GRB2, ERBB2, CDH1, BAD, CTNNA2, SOS1, CTNNA1, PDPK1, CTNNB1, GSK3B, PIK3CD, TP53, LEF1",1.09097914578884,0.22548303427145,FALSE +"HCC44","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.40431,-1.19,0.242,5983,0.678,"RELA, ATP6AP1, PTPN11, ATP6V0A2, LYN, MAPK10, ADAM17, IKBKB, ATP6V0D1, CASP3, ATP6V1B2, ATP6V1A, ATP6V1E1, MAPK14, ATP6V1B1, ATP6V0A1, ADAM10, ATP6V1C2, MAPK13, ATP6V1H, ATP6V1F, MAPK12, GIT1, ATP6V1C1, ATP6V1D, F11R, PLCG1, PTPRZ1, SRC, CSK, PLCG2, JAM3",0.616184634019569,0.168770306132937,FALSE +"HCC44","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.33069,-0.97,0.43,7099,0.666,"PIK3CA, RAF1, CDKN1A, CAMK2B, AKT2, PAK4, MAPK1, MAPK3, CAMK2D, GRB2, ERBB2, BAD, PLCG1, SOS1, SRC, NCK2, PAK5, PAK6, GSK3B, PIK3CD, AREG, ERBB3, EIF4EBP1, PLCG2",0.366531544420413,0.176525770829699,FALSE +"HCC44","Input","KEGG_ETHER_LIPID_METABOLISM",0.44664,1.42,0.0982,1947,0.4,"PLA2G4A, PLPP3, LPCAT1, PLD1, PLA2G12A, CHPT1, PLPP2",1.00788851221305,0.397940008672038,FALSE +"HCC44","Input","KEGG_FATTY_ACID_METABOLISM",-0.36034,-1.06,0.357,8430,0.624,"ADH4, ADH7, ACADS, ACSL1, ADH5, ACSL6",0.447331783887807,0.204815410317576,FALSE +"HCC44","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.35271,-1.04,0.41,6863,0.608,"MAPK14, GAB2, PIK3CA, RAF1, AKT2, MAPK13, MAPK1, VAV2, MAPK3, BTK, MAPK12, GRB2, PRKCD, PLCG1, SOS1, MAP2K6, VAV3, PDPK1, PIK3CD, SYK, RAC3, PLCG2",0.387216143280265,0.216096420727265,FALSE +"HCC44","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.27993,-0.824,0.661,7099,0.835,"PIK3CA, RAF1, LIMK2, AKT2, MAPK1, PLPP1, VAV2, MAPK3, MYO10, ARPC1A, ASAP1, PRKCD, PLCG1, VAV3, PTPRC, SCIN, WASF3, MARCKSL1, PIK3CD, SYK, ASAP3, GSN, PLCG2",0.17979854051436,0.0783135245163979,FALSE +"HCC44","Input","KEGG_FOCAL_ADHESION",0.27716,0.863,0.632,986,0.762,"RAC2, FLNC, JUN, LAMC2, VEGFA, COL4A1, ZYX, ITGA1, LAMB3, LAMB1, ITGA2, CAV2, FLNB, ACTN1, COL4A2, LAMA2, ACTN4, ITGA3, ITGB3, COL6A1, FLNA, BIRC2, ACTN2, ITGB1, ITGA5, VCL, MYLK, MYL12A, MYL9, COL6A2",0.199282921717615,0.1180450286604,FALSE +"HCC44","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.64236,-1.88,0.0141,8355,0.311,"DHFR, GCH1, ALPI, ALPP",1.85078088734462,0.507239610973163,FALSE +"HCC44","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.53878,-1.57,0.065,6785,0.399,"PFKL, ALDOA, AKR1B10, MTMR6, HK1, PFKFB2, MPI, PFKFB4, ALDOC, FBP1, ALDOB, KHK",1.18708664335714,0.399027104313252,FALSE +"HCC44","Input","KEGG_GALACTOSE_METABOLISM",-0.2428,-0.711,0.844,7781,0.921,"HK1, GAA, GALT",0.073657553374345,0.0357403698031511,FALSE +"HCC44","Input","KEGG_GAP_JUNCTION",-0.26558,-0.77,0.729,7044,0.862,"PLCB2, GNAQ, RAF1, CSNK1D, ADCY9, PLCB3, MAPK1, MAPK3, GNA11, GRB2, SOS1, SRC, CDK1, PLCB4",0.137272471682025,0.0644927341752872,FALSE +"HCC44","Input","KEGG_GLIOMA",-0.42945,-1.23,0.217,7099,0.634,"PIK3CA, RAF1, CDKN1A, CAMK2B, AKT2, MAPK1, MAPK3, CCND1, CAMK2D, GRB2, PLCG1, SOS1, PIK3CD, CALM2, RB1, PLCG2, CALML3, TP53",0.66354026615147,0.197910742118267,FALSE +"HCC44","Input","KEGG_GLUTATHIONE_METABOLISM",-0.37557,-1.09,0.301,7126,0.655,"GSTM3, GSTT2, IDH2, RRM2, PGD, IDH1, GPX2, MGST2, MGST3, OPLAH, GSTM1, RRM2B, GSTP1, GSTM4",0.521433504406157,0.183758700008217,FALSE +"HCC44","Input","KEGG_GLYCEROLIPID_METABOLISM",0.24485,0.747,0.78,1947,0.87,"PLPP3, GPAT3, ALDH2, GK, DGKE, ALDH1B1, AGK, AGPAT1, PLPP2",0.10790539730952,0.0604807473813815,FALSE +"HCC44","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.3003,0.909,0.526,2217,0.763,"PLA2G4A, PLPP3, GPAT3, LPCAT1, MBOAT7, PLD1, PTDSS2, DGKE, PLA2G12A, CDS1, CHPT1, AGPAT1, PLPP2, PTDSS1, AGPAT2",0.279014255846261,0.11747546204512,FALSE +"HCC44","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.33536,-0.989,0.432,7499,0.651,"MAOB, GAMT, PHGDH, MAOA, GLDC, GATM, SARDH",0.364516253185088,0.186419011431808,FALSE +"HCC44","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.44793,-1.31,0.151,8430,0.603,"ADH4, ADH7, ALDOC, ACSS2, FBP1, ALDOB, ADH5, ACSS1, PGAM2",0.821023052706831,0.219682687859849,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.44936,1.37,0.154,2434,0.412,"DSE, CHST12, CHST7, B3GALT6, CHPF, CHSY3",0.812479279163537,0.385102783966865,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.35868,-1.04,0.363,5526,0.608,"EXTL2, B3GAT3, GLCE, NDST1, HS2ST1, EXTL3, EXT2",0.440093374963888,0.216096420727265,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.51964,1.61,0.0678,826,0.345,"ST3GAL2, B4GALT1, FUT8",1.16877030613294,0.462180904926726,FALSE +"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.32816,1.03,0.385,1110,0.65,"IDS, IDUA, GUSB, NAGLU",0.414539270491499,0.187086643357144,FALSE +"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.37161,1.15,0.257,2769,0.66,"ST3GAL2, SLC33A1, HEXA, GLB1",0.590066876668705,0.180456064458131,FALSE +"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.38117,1.2,0.204,2169,0.625,"ST3GAL2, B3GALNT1, HEXA",0.690369832574101,0.204119982655925,FALSE +"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.38501,1.19,0.233,820,0.622,"FUT4, B4GALT1",0.632644078973981,0.206209615309181,FALSE +"HCC44","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.24229,-0.708,0.822,5223,0.915,"PIGG, PIGS, PIGK, PIGH, PIGO, PIGT, GPAA1, PIGU, PIGQ, PGAP1",0.0851281824599496,0.0385789059335517,FALSE +"HCC44","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.34536,1.08,0.312,2243,0.631,"MTHFD2, MTHFD1L, MTHFD1",0.505845405981557,0.199970640755866,FALSE +"HCC44","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.29929,-0.887,0.575,6782,0.755,"PLCB1, MAP3K3, MAPK14, PLCB2, GNAQ, RAF1, CAMK2B, MAPK13, ADCY9, PLCB3, MAPK1, MAP3K4, MAPK3, GNA11, MAPK12, CAMK2D, GRB2, PRKCD, SOS1, MAP2K6, SRC, CGA, CALM2, CALML3, PLCB4",0.24033215531037,0.122053048370812,FALSE +"HCC44","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.35594,-1.04,0.365,6848,0.608,"CSNK1G3, WNT5A, BTRC, CSNK1E, SUFU, CSNK1D, WNT11, CSNK1G1, CSNK1A1, BMP6, GSK3B",0.437707135543525,0.216096420727265,FALSE +"HCC44","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.52514,1.66,0.0491,846,0.337,"ANPEP, CD37, ITGA1, CD44, ITGA2, EPO, CSF1, CD38, ITGA3, ITGB3, CD55, ITGA5",1.30891850787703,0.472370099128661,FALSE +"HCC44","Input","KEGG_HISTIDINE_METABOLISM",0.33112,1.02,0.371,677,0.641,"ALDH1A3, ALDH2, ALDH3B1",0.430626090384954,0.193141970481183,FALSE +"HCC44","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.26237,0.805,0.696,3877,0.825,"SSBP1, RAD50, NBN, TOP3B, RPA1, EME1, POLD3, MRE11, RPA2, POLD1, POLD2, RPA3",0.157390760389438,0.0835460514500749,FALSE +"HCC44","Input","KEGG_HUNTINGTONS_DISEASE",0.17395,0.552,0.987,3114,1,"SOD2, TGM2, SDHA, POLR2I, ATP5MC2, NDUFA10, NDUFA7, SDHD, POLR2K, SDHC, NDUFC1, NDUFV3, TBP, AP2A1, UQCRH, RCOR1, NDUFS6, NDUFS5, AP2B1, NDUFB7, AP2S1, PPID, DNAL1, TFAM, NDUFS3, NDUFA3, NDUFA5, NDUFV1, CYCS, ITPR1, HAP1, GPX1, AP2A2, NDUFB4, NDUFS8, VDAC1, IFT57, HDAC2, NDUFA2, NDUFB9, NDUFA8, BAX, NDUFS2, SDHB, NDUFS4, COX7A2L, NDUFB1, AP2M1, DLG4, DCTN1",0.00568284733036327,0,FALSE +"HCC44","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.33486,-0.971,0.457,7785,0.674,"TPM1, PRKAG1, ITGB4, TPM3, IL6, DAG1, SGCB, ACE, ITGB6, ITGA6, ITGA11, SGCG, CACNA2D1, ITGA4, ITGB8",0.34008379993015,0.17134010346468,FALSE +"HCC44","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.43038,-1.26,0.183,6671,0.613,"PI4KA, PLCB1, PIP4K2C, PLCB2, PIK3CA, INPP1, PI4KB, PLCB3, ITPKB, IMPA2, INPPL1, PLCG1, ISYNA1, PLCD1, INPP5A, PIK3CD, PLCG2, PLCB4",0.737548910269571,0.212539525481585,FALSE +"HCC44","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.31983,-0.94,0.493,6396,0.703,"SHC1, ELK1, PIK3R1, PYGB, PIK3R2, IRS1, GYS1, RAPGEF1, EIF4E2, PHKA2, INSR, PTPN1, PIK3CA, TSC2, FASN, RAF1, AKT2, MAPK1, PRKAA1, MAPK3, GRB2, HK1, PRKAG1, PRKAR2B, BAD, SOS1, PDPK1, GSK3B, PIK3CD, CALM2, PTPRF, EIF4EBP1, PDE3A, FBP1, CALML3, PRKCZ",0.30715308072277,0.153044674980176,FALSE +"HCC44","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.52442,1.62,0.0392,102,0.36,"CD40, TGFB1",1.40671393297954,0.443697499232713,FALSE +"HCC44","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.30632,-0.901,0.556,6961,0.749,"IL10RB, TYK2, PIK3CA, AKT2, CREBBP, STAM2, CCND1, IFNGR1, IL13RA1, GRB2, OSM, PTPN6, STAT1, STAT2, PIAS1, IL6, SOS1, LIFR, IFNAR1, IL13RA2, IL6ST, PIK3CD",0.254925208417942,0.125518182300534,FALSE +"HCC44","Input","KEGG_LEISHMANIA_INFECTION",0.55087,1.69,0.0438,281,0.372,"ITGB2, PTGS2, JUN, TGFB1, CYBA, TGFB2, C3, NCF2",1.3585258894959,0.429457060118102,FALSE +"HCC44","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.32492,1.02,0.417,961,0.641,"RAC2, ITGB2, ICAM1, CYBA, CLDN11, NCF2, MSN, ACTN1, ACTN4, ACTN2, ITGB1, VCL, MYL12A, MYL9",0.379863945026242,0.193141970481183,FALSE +"HCC44","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.53891,1.68,0.0473,1312,0.346,"ALDH2, EHHADH, YOD1, ALDH1B1",1.32513885926219,0.460923901207223,FALSE +"HCC44","Input","KEGG_LONG_TERM_DEPRESSION",-0.26772,-0.806,0.723,6096,0.838,"LYN, GNAI3, ARAF, GNAI1, PPP2CA, PLCB1, NOS1, GNA13, PLCB2, GNAQ, RAF1, PLCB3, MAPK1, MAPK3, GNA11, GNA12, GNAO1, PLCB4",0.140861702705469,0.0767559813697235,FALSE +"HCC44","Input","KEGG_LONG_TERM_POTENTIATION",-0.36226,-1.05,0.367,6646,0.621,"RPS6KA1, EP300, PLCB1, RPS6KA6, PLCB2, GNAQ, RAF1, PPP3CC, CAMK2B, CREBBP, PLCB3, MAPK1, MAPK3, CAMK2D, GRIN1, CALM2, CALML3, PPP3R1, PLCB4",0.435333935747911,0.20690839982342,FALSE +"HCC44","Input","KEGG_LYSINE_DEGRADATION",0.24475,0.755,0.794,1718,0.868,"PLOD2, ALDH2, AASS, SETD7, EHHADH, ALDH1B1, PLOD1, PLOD3, DLST, GCDH",0.100179497572904,0.0614802748235081,FALSE +"HCC44","Input","KEGG_LYSOSOME",-0.20812,-0.604,0.953,6740,0.977,"GLA, SMPD1, ACP5, ATP6V0A1, PSAP, AP3M2, CLN3, NPC2, HGSNAT, ATP6V1H, CTSA, AP1S2, SLC11A2, NAGA, CD63, SORT1, AP4E1, SCARB2, LIPA, ASAH1, LAPTM4B, AP1M2, ABCA2, NEU1, CTSF, GAA, GM2A, AP3B2, CTSH, GALC",0.0209070993616736,0.0101054362812269,FALSE +"HCC44","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.3273,1.01,0.413,502,0.645,"RAC2, MYC, FLNC, JUN, ATF4, PLA2G4A, TGFB1, TGFB2, NFKB2, RELB, MECOM, MKNK1, FLNB, MOS, FGF13, FGF2, ELK4, DDIT3",0.384049948343599,0.190440285364732,FALSE +"HCC44","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.72348,2.21,0.00258,1780,0.299,"IAPP, GCK, HES1, FOXA2",2.58838029403677,0.52432881167557,FALSE +"HCC44","Input","KEGG_MELANOGENESIS",-0.55602,-1.63,0.0518,6694,0.393,"EP300, PLCB1, WNT5A, FZD1, PLCB2, GNAQ, RAF1, CAMK2B, CREBBP, WNT11, ADCY9, PLCB3, MAPK1, TCF7L2, TCF7L1, MAPK3, CAMK2D, FZD6, CTNNB1, GSK3B, CALM2, GNAO1, KIT, CALML3, PLCB4, LEF1",1.28567024025477,0.405607449624573,FALSE +"HCC44","Input","KEGG_MELANOMA",-0.34994,-1.03,0.387,7099,0.595,"PIK3CA, RAF1, CDKN1A, AKT2, MAPK1, MAPK3, CCND1, CDH1, BAD, HGF, PIK3CD, RB1, FGFR1, TP53",0.412289034981089,0.22548303427145,FALSE +"HCC44","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.58979,-1.74,0.0393,7957,0.475,"AKR1C2, AKR1C3, AKR1C1, EPHX1, MGST2, ADH4, ADH7, MGST3, CYP1A1, GSTM1, ADH5, GSTP1, GSTM4",1.40560744962457,0.323306390375133,FALSE +"HCC44","Input","KEGG_MISMATCH_REPAIR",0.36698,1.12,0.278,3877,0.621,"SSBP1, MLH1, MSH3, RFC1, RFC3, PMS2, RPA1, POLD3, MSH2, RPA2, POLD1, RFC4, RFC2, POLD2, RPA3",0.555955204081924,0.20690839982342,FALSE +"HCC44","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.39091,-1.15,0.267,5532,0.67,"AKT1, RPS6KA3, RPS6KB2, RPS6KA2, BRAF, RPS6KB1, PIK3CB, RICTOR, STRADA, PIK3R1, PIK3R2, RPS6KA1, CAB39, EIF4E2, RPS6KA6, PIK3CA, TSC2, AKT2, ULK1, MAPK1, PRKAA1, MAPK3, CAB39L, PDPK1, PIK3CD, EIF4EBP1",0.573488738635425,0.173925197299174,FALSE +"HCC44","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.29373,0.918,0.517,140,0.774,"RAC2, ITGB2, ICAM1, TNFRSF10B",0.286509456906058,0.111259039317107,FALSE +"HCC44","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.28383,-0.837,0.646,7533,0.82,"CHRNE, GRIN1, PLG, F2, CGA, HCRTR1",0.189767482004916,0.0861861476162833,FALSE +"HCC44","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.3974,-1.17,0.258,6584,0.682,"PIK3R2, IRS1, RAPGEF1, RPS6KA1, GAB1, MAP3K3, MAPK14, RPS6KA6, SH2B1, PIK3CA, RAF1, CAMK2B, AKT2, MAPK13, MAPK1, YWHAB, MAPK3, MAPK12, NFKBIE, CAMK2D, GRB2, YWHAZ, SORT1, PRKCD, BAD, PLCG1, SOS1, MAPKAPK2, PDPK1, FRS2, CSK, GSK3B, PIK3CD, CALM2, BCL2, MAGED1, PLCG2, ARHGDIB, CALML3, TP53, TP73, NGFR",0.58838029403677,0.166215625343521,FALSE +"HCC44","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.38997,1.21,0.207,806,0.628,"NAMPT, NT5E, NNMT, PNP, CD38, ENPP1",0.684029654543082,0.202040356262804,FALSE +"HCC44","Input","KEGG_NITROGEN_METABOLISM",-0.68798,-2.03,0.00812,8712,0.177,"GLUL, CA3, GLUD2",2.09044397075882,0.752026733638193,TRUE +"HCC44","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.19739,-0.579,0.966,7323,0.984,"MAPK13, MAPK1, CCL13, MAPK3, MAPK12, CASP8, IL6, CARD8, TAB3",0.0150228735845067,0.00700490156865849,FALSE +"HCC44","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.33699,1.04,0.352,3676,0.694,"XRCC4, XRCC5, RAD50, LIG4, MRE11, XRCC6, DCLRE1C, PRKDC",0.453457336521869,0.158640529545145,FALSE +"HCC44","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.3733,-1.1,0.3,7099,0.663,"PIK3CA, RAF1, AKT2, CASP9, MAPK1, RXRA, MAPK3, CCND1, GRB2, ERBB2, RXRG, BAD, PLCG1, SOS1, PDPK1, PIK3CD, RB1, PLCG2, TP53",0.522878745280338,0.178486471595227,FALSE +"HCC44","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.54645,-1.63,0.0447,7246,0.393,"CREBBP, LFNG, MAML2, NCSTN, DLL1, APH1A, DLL3, JAG1, DTX3L, NOTCH3, DLL4",1.34969247686806,0.405607449624573,FALSE +"HCC44","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.1578,0.48,0.992,7687,0.997,"ERCC2, GTF2H2, CCNH, GTF2H1, GTF2H3, GTF2H4, MNAT1, RFC1, RFC3, RPA1, POLD3, XPA, ERCC5, RPA2, POLD1, RFC4, RFC2, POLD2, RAD23A, RPA3, CDK7, POLE3, RFC5, POLD4, POLE4, ERCC4, CUL4A, ERCC3, LIG1, PCNA, CUL4B, DDB2, RAD23B, GTF2H5, DDB1, XPC, POLE, ERCC6, CETN2",0.00348832784582135,0.00130484168834428,FALSE +"HCC44","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.40193,-1.16,0.266,9117,0.684,"MAN1C1",0.575118363368933,0.164943898279884,FALSE +"HCC44","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.57695,-1.7,0.0373,7230,0.435,"CAMK2B, ARRB2, CAMK2D, CLCA2, CALM2, CALML3",1.42829116819131,0.361510743045363,FALSE +"HCC44","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.36623,1.12,0.28,2243,0.621,"MTHFD2, MTHFR, SHMT2, MTHFD1L, GART, MTFMT, MTHFD1",0.552841968657781,0.20690839982342,FALSE +"HCC44","Input","KEGG_OOCYTE_MEIOSIS",-0.44054,-1.29,0.164,6898,0.619,"PPP2R5A, CDC25C, RPS6KA6, BTRC, PPP2R5D, PPP2R5B, PPP3CC, CAMK2B, ADCY9, CDK2, MAPK1, AURKA, PLK1, PTTG1, SKP1, YWHAB, MAPK3, ANAPC4, CCNB2, MAPK12, SGO1, CAMK2D, YWHAZ, CDC20, BUB1, CCNB1, CDK1, FBXO5, CALM2, PKMYT1, CALML3, PPP3R1",0.785156151952302,0.208309350979882,FALSE +"HCC44","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.46926,1.48,0.0896,2769,0.434,"FUCA1, FUCA2, MAN2B2, MAN2B1, MANBA, HEXA, ENGASE, GLB1",1.04769199033787,0.362510270487489,FALSE +"HCC44","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.17295,0.531,0.985,3054,1,"COX11, SDHA, ATP5MC2, COX17, TCIRG1, NDUFA10, NDUFA7, SDHD, SDHC, NDUFC1, NDUFV3, UQCRH, NDUFS6, NDUFS5, NDUFB7, NDUFA11, NDUFS3, NDUFA3, NDUFA5, ATP5ME, NDUFV1, NDUFB4, NDUFS8, NDUFA2, NDUFB9, NDUFA8, NDUFS2, SDHB, NDUFS4, COX7A2L, NDUFB1",0.00656376950238827,0,FALSE +"HCC44","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.55789,1.78,0.0205,1574,0.41,"GALNT14, GALNT11, GALNT6, ST3GAL2, C1GALT1, GALNT15, C1GALT1C1, GALNT16, GALNT17",1.68824613894425,0.387216143280265,FALSE +"HCC44","Input","KEGG_P53_SIGNALING_PATHWAY",-0.39537,-1.15,0.274,7115,0.67,"TSC2, FAS, CDKN1A, CDK2, CASP9, RRM2, CCND1, CCNB3, COP1, CCNB2, CASP8, CHEK1, CCNB1, IGFBP3, CDK1, THBS1, RRM2B, TP53, TP73",0.562249437179612,0.173925197299174,FALSE +"HCC44","Input","KEGG_PANCREATIC_CANCER",0.33514,1.03,0.377,181,0.65,"RAC2, TGFB1, CDKN2A, TGFA, VEGFA, TGFB2",0.423658649794207,0.187086643357144,FALSE +"HCC44","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.32182,-0.945,0.497,6600,0.704,"PPCDC, BCAT2, PANK2, DPYD, PPCS",0.303643611266668,0.152427340857888,FALSE +"HCC44","Input","KEGG_PARKINSONS_DISEASE",0.20479,0.634,0.929,3177,0.98,"UCHL1, SDHA, UBE2J2, ATP5MC2, NDUFA10, NDUFA7, SDHD, SDHC, NDUFC1, NDUFV3, UQCRH, NDUFS6, NDUFS5, NDUFB7, SLC18A1, PPID, NDUFS3, NDUFA3, NDUFA5, NDUFV1, CYCS, NDUFB4, NDUFS8, PARK7, VDAC1, NDUFA2, NDUFB9, NDUFA8, NDUFS2, SDHB, NDUFS4, COX7A2L, NDUFB1, HTRA2, NDUFC2",0.0319842860063582,0.00877392430750515,FALSE +"HCC44","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.17262,-0.501,0.993,7725,1,"YWHAZ, CDH1, ARPC1A, NCK2, CTNNB1",0.00305075150461883,0,FALSE +"HCC44","Input","KEGG_PATHWAYS_IN_CANCER",0.29139,0.891,0.53,654,0.771,"RAC2, PTGS2, TRAF1, SMO, MYC, MMP1, JUN, TGFB1, CDKN2A, TGFA, LAMC2, VEGFA, TGFB2, COL4A1, NFKB2, MECOM, LAMB3, LAMB1, ITGA2, COL4A2, FGF13, FGF2, LAMA2, ITGA3, NFKB1",0.275724130399211,0.112945621949043,FALSE +"HCC44","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.27016,-0.804,0.694,6692,0.831,"XYLB, RPE, CRYL1, DCXR",0.158640529545145,0.080398976215889,FALSE +"HCC44","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.2787,-0.818,0.64,8757,0.836,"ALDOC, FBP1, ALDOB",0.193820026016113,0.0777937225609836,FALSE +"HCC44","Input","KEGG_PEROXISOME",-0.35755,-1.05,0.356,7202,0.621,"PEX11A, PECR, IDH2, NUDT12, PRDX5, SLC27A2, ACOX1, IDH1, PMVK, PXMP4, CROT, PHYH, EPHX2, AMACR, ACSL1, MVK, FAR1, ACSL6",0.448550002027125,0.20690839982342,FALSE +"HCC44","Input","KEGG_PHENYLALANINE_METABOLISM",-0.3629,-1.06,0.36,7308,0.624,"ALDH3A1, PRDX6, MAOB, MAOA, TAT, DDC",0.443697499232713,0.204815410317576,FALSE +"HCC44","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.35587,-1.03,0.38,6489,0.595,"PIK3R1, PIK3R2, PI4KA, PLCB1, PIP4K2C, DGKZ, PLCB2, PIK3CA, INPP1, PI4KB, PLCB3, DGKD, ITPKB, IMPA2, INPPL1, PLCG1, PLCD1, INPP5A, PIK3CD, CALM2, PLCG2, CALML3, PLCB4",0.42021640338319,0.22548303427145,FALSE +"HCC44","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.26804,-0.789,0.701,7116,0.848,"BLVRA, COX15, HMOX1, ALAD, BLVRB, FTH1",0.154281982033341,0.0716041477432862,FALSE +"HCC44","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.42759,-1.24,0.182,7011,0.633,"SLC27A1, UBC, OLR1, RXRA, ANGPTL4, SLC27A2, FABP3, ACOX1, FADS2, RXRG, CD36, FABP4, PDPK1, CYP27A1, SCD, SCD5, FABP7, LPL, APOC3, ACSL1, ACSL6",0.739928612014925,0.198596289982645,FALSE +"HCC44","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.48641,1.52,0.0767,871,0.404,"CD40, RFXAP, RFX5, TAP2",1.11520463605102,0.393618634889395,FALSE +"HCC44","Input","KEGG_PRION_DISEASES",-0.31073,-0.905,0.548,6344,0.751,"NOTCH1, ELK1, STIP1, HSPA1A, MAPK1, LAMC1, MAPK3, C9, IL6, NCAM1",0.261219441515631,0.124360062995832,FALSE +"HCC44","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.46332,-1.37,0.138,5532,0.559,"AKT1, RPS6KA3, MAPK9, HSP90AA1, RPS6KA2, BRAF, GNAI2, KRAS, PIK3CB, MAD2L1, ANAPC7, MAPK10, GNAI3, ARAF, ADCY5, GNAI1, PIK3R1, PIK3R2, RPS6KA1, MAPK14, CDC25C, RPS6KA6, PIK3CA, RAF1, AKT2, MAPK13, ADCY9, CDK2, MAPK1, PLK1, MAPK3, ANAPC4, CCNB3, CCNA2, CCNB2, MAPK12, FZR1, BUB1, CCNB1, PIK3CD, CDK1, PDE3A, PKMYT1",0.860120913598763,0.252588192113577,FALSE +"HCC44","Input","KEGG_PROPANOATE_METABOLISM",-0.37351,-1.1,0.299,8834,0.663,"ACSS2, ABAT, ACSS1",0.52432881167557,0.178486471595227,FALSE +"HCC44","Input","KEGG_PROSTATE_CANCER",-0.47638,-1.39,0.123,7099,0.631,"PIK3CA, RAF1, CDKN1A, AKT2, CREBBP, CDK2, CASP9, MAPK1, TCF7L2, TCF7L1, MAPK3, CCND1, GRB2, ERBB2, BAD, SOS1, PDPK1, CTNNB1, GSK3B, PIK3CD, BCL2, RB1, FGFR1, GSTP1, TP53, LEF1",0.910094888560602,0.199970640755866,FALSE +"HCC44","Input","KEGG_PROTEASOME",0.58921,1.8,0.0339,3061,0.458,"PSMB10, PSMB9, PSMB8, PSME1, PSMA6, PSME4, PSMB4, PSMC2, PSME2, PSME3, PSMD2, PSMA4, PSMC1, PSMB3, PSMC5, PSMA3, PSMA8, PSMD8, PSMD13, PSMD4, PSMA5, PSMD1, PSMD12, PSMC4, PSMA7, PSMD14, PSMD11, PSMC6, PSMA1, PSMD6, PSMC3, PSMD7, PSMF1, PSMB1, PSMB2, PSMD3",1.46980030179692,0.339134521996131,FALSE +"HCC44","Input","KEGG_PROTEIN_EXPORT",0.34728,1.08,0.348,3320,0.631,"SEC61B, SEC61A1, SRP19, SRP72, SEC62, HSPA5, SRPRA, SRP68, OXA1L, SPCS1, SRP54, SEC63, SRPRB",0.458420756053419,0.199970640755866,FALSE +"HCC44","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.59487,-1.72,0.0421,9114,0.452,"GLUD2",1.37571790416433,0.344861565188618,FALSE +"HCC44","Input","KEGG_PURINE_METABOLISM",0.26579,0.802,0.669,1982,0.818,"FHIT, NT5E, POLR2I, PNP, PNPT1, ENPP1, AK4, GMPS, PFAS, HPRT1, POLR3G, PAICS, PRPS1, PRPS1L1, PDE6C, POLR1E, ADSL, POLR2K, GART, PPAT, GDA, NME7, DGUOK, PDE4D, NUDT5, GMPR2, APRT, ADK, PDE6D, ENTPD4",0.174573882232177,0.087246696328677,FALSE +"HCC44","Input","KEGG_PYRIMIDINE_METABOLISM",0.22738,0.679,0.869,1354,0.939,"CDA, NT5E, UPP1, TXNRD1, POLR2I, PNP, TYMP, PNPT1, DHODH, POLR3G, POLR1E, AK3, POLR2K",0.0609802235513335,0.0273344077338891,FALSE +"HCC44","Input","KEGG_PYRUVATE_METABOLISM",-0.22222,-0.637,0.914,8834,0.966,"ACSS2, ACSS1",0.0390538042661686,0.0150228735845067,FALSE +"HCC44","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.25467,0.789,0.682,961,0.818,"RAC2, ITGB2, ITGA1, CFL2, ITGA2, MSN, MYH9, DIAPH2, ACTN1, MOS, FGF13, FGF2, SSH1, ACTN4, ITGA3, DIAPH3, ITGB3, PIP4K2A, ARHGEF1, ACTN2, ITGB1, LIMK1, ITGA5, VCL, MYLK, MYL12A, MYL9",0.166215625343521,0.087246696328677,FALSE +"HCC44","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.47454,-1.37,0.139,6794,0.559,"GABARAPL1, GABARAPL2, ATG4D, ULK1, PRKAA1, ATG4B",0.856985199745905,0.252588192113577,FALSE +"HCC44","Input","KEGG_RENAL_CELL_CARCINOMA",0.33432,1.03,0.375,181,0.65,"JUN, TGFB1, TGFA, VEGFA, TGFB2",0.425968732272281,0.187086643357144,FALSE +"HCC44","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.35719,1.11,0.274,1130,0.622,"ANPEP, LNPEP, THOP1",0.562249437179612,0.206209615309181,FALSE +"HCC44","Input","KEGG_RETINOL_METABOLISM",-0.47464,-1.38,0.128,7497,0.623,"RETSAT, PNPLA4, RDH16, ADH4, ADH7, CYP1A1, ADH5, ALDH1A1",0.892790030352132,0.20551195334083,FALSE +"HCC44","Input","KEGG_RIBOFLAVIN_METABOLISM",0.46958,1.45,0.118,806,0.402,"ACP6, ENPP1",0.928117992693875,0.39577394691553,FALSE +"HCC44","Input","KEGG_RIBOSOME",0.50097,1.57,0.0638,3274,0.364,"RPL37, RPL29, RPL24, RSL24D1, RPS25, RPL11, RPL27, RPL22, RPL18, RPL4, RPL38, RPL12, RPS7, RPL17, RPL32, RPL9, RPL26, RPL37A, RPL28, RPL30, FAU, RPL27A, RPL36, RPL5, RPS27L, MRPL13, RPL13, RPL14, RPL10A, RPS29, RPL3, RPL18A, RPL10, RPL15, RPL35A, RPSA, RPL34, RPL23, RPS16, RPS12, RPLP0, RPL7, RPL36A, RPL36AL, RPL21, RPS11, RPL19, RPL7A, RPS6, RPL23A, RPL13A, RPL6, RPS15A, RPLP1, RPS20, RPS28, RPS21, RPS24, RPS23, RPL35, RPS10, RPL8, RPS3A",1.19517932127884,0.438898616350944,FALSE +"HCC44","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.16714,-0.494,0.992,5983,0.994,"RELA, MAPK10, IKBKB, MAP3K7, MAP3K1, MAPK14, IFIH1, MAPK13, MAPK12, CASP8, DDX58, FADD, TKFC",0.00348832784582135,0.00261361560268669,FALSE +"HCC44","Input","KEGG_RNA_DEGRADATION",0.45354,1.42,0.114,1963,0.4,"EXOSC2, EXOSC9, DIS3, EXOSC1, PNPT1, DCPS, EXOSC5, EXOSC8, EXOSC6, EXOSC3, EXOSC7, DCP2, MTREX, EXOSC4, PAPOLA, ZCCHC7, EXOSC10, LSM6, MPHOSPH6, LSM2",0.943095148663527,0.397940008672038,FALSE +"HCC44","Input","KEGG_RNA_POLYMERASE",0.3448,1.08,0.316,2931,0.631,"POLR2I, POLR3G, POLR1E, POLR2K, POLR3H, POLR1A, POLR3F, POLR3C",0.500312917381596,0.199970640755866,FALSE +"HCC44","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.54971,1.73,0.045,2526,0.363,"CTH, GGT1, SCLY, CBS, AHCYL1, MAT2B, MARS2, AHCYL2, MAT1A, BUD23, MAT2A",1.34678748622466,0.440093374963888,FALSE +"HCC44","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.40313,1.24,0.203,799,0.595,"PTGS2, TRAF1, MYC, FHIT, LAMC2, COL4A1, LAMB3, LAMB1, ITGA2, COL4A2, LAMA2, ITGA3, NFKB1, BIRC2, ITGB1",0.692503962086787,0.22548303427145,FALSE +"HCC44","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.27597,0.867,0.559,1519,0.78,"STX11, VAMP5, BET1, VAMP3, STX10, STX16, VAMP8",0.252588192113577,0.10790539730952,FALSE +"HCC44","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.28032,-0.812,0.678,8031,0.837,"ASAH1, DEGS1, NEU1, CERK, SMPD3, GALC",0.168770306132937,0.07727454200674,FALSE +"HCC44","Input","KEGG_SPLICEOSOME",0.4694,1.46,0.0709,3621,0.436,"HNRNPU, THOC1, TXNL4A, SNRPB, DDX46, PRPF31, U2AF1, SNRNP40, NCBP2, SLU7, THOC2, DHX38, SNRNP70, PRPF40A, U2AF2, SNRPA1, CDC40, SNRPF, THOC3, DDX42, PRPF4, LSM6, PRPF6, NCBP1, RBM22, RBM17, DHX16, DDX39B, SNRPD3, PRPF38A, DDX23, CHERP, SMNDC1, LSM2, ZMAT2, PRPF38B, SNRNP27, SF3B6, SRSF8, ACIN1, ALYREF, RBM25, PPIE, DHX8, SRSF2, SNRPG, PRPF3, SNW1, HNRNPC, SNRPC, EFTUD2, SNRPA, SART1, PRPF8, HNRNPM, LSM8, SNU13, TCERG1, SF3B4, PHF5A, SRSF1, RBM8A, SNRNP200, SNRPD1, SNRPD2, CWC15, EIF4A3, SF3B5, SNRPB2, PQBP1, SF3A3, SF3B2, U2SURP, SF3B3, PRPF19, SRSF7, CTNNBL1, SF3A1, SYF2, BCAS2, SRSF3, HNRNPK, PLRG1, WBP11, HNRNPA3, HNRNPA1, PPIL1, SF3A2, TRA2B, SRSF5, MAGOHB",1.14935376481693,0.360513510731414,FALSE +"HCC44","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.35956,1.12,0.287,1511,0.621,"PYGL, GCK, ENPP1, GUSB, GBE1, UGDH, UXS1",0.542118103266008,0.20690839982342,FALSE +"HCC44","Input","KEGG_STEROID_BIOSYNTHESIS",-0.72797,-2.14,0.00327,7448,0.251,"LSS, HSD17B7, DHCR24, CYP51A1, CEL, LIPA, MSMO1, SQLE, SC5D, FDFT1",2.48545224733971,0.600326278518962,FALSE +"HCC44","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.72218,-2.11,0.00818,7438,0.202,"CYP21A2, HSD17B7, AKR1C2, AKR1D1, AKR1C3, AKR1C1, STS, SULT2B1, CYP1A1, CYP11B1, HSD11B2",2.08724669632868,0.694648630553376,TRUE +"HCC44","Input","KEGG_SULFUR_METABOLISM",-0.79031,-2.35,0,8714,0.132,"SULT2B1, SUOX, SULT1A1",Inf,0.87942606879415,TRUE +"HCC44","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.44235,1.37,0.131,1123,0.412,"CD40, C3, ACTN1, ACTN4, ACTN2, SNRPB",0.882728704344236,0.385102783966865,FALSE +"HCC44","Input","KEGG_TASTE_TRANSDUCTION",-0.3859,-1.13,0.289,8469,0.647,"SCNN1A, ASIC2",0.539102157243452,0.1890957193313,FALSE +"HCC44","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.69095,-2.05,0.00859,7947,0.2,"IDI1, PMVK, HMGCR, MVK, HMGCS1",2.06600683616876,0.698970004336019,TRUE +"HCC44","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.25426,-0.748,0.799,7246,0.89,"CREBBP, MAPK1, SKP1, MAPK3, SMAD5, DCN, SMURF2, LTBP1, BMP6, INHBA, ACVR1, FST, THBS1",0.0974532206860086,0.0506099933550872,FALSE +"HCC44","Input","KEGG_THYROID_CANCER",-0.53967,-1.59,0.0541,7376,0.396,"MAPK1, RXRA, TCF7L2, TCF7L1, MAPK3, CCND1, CDH1, RXRG, TPM3, CTNNB1, NCOA4, TP53, LEF1",1.26680273489343,0.402304814074488,FALSE +"HCC44","Input","KEGG_TIGHT_JUNCTION",-0.389,-1.14,0.282,8009,0.657,"F11R, PRKCD, PATJ, TJP3, EPB41L1, CTNNA2, PARD6G, CTNNA1, LLGL2, SRC, CTNNB1, CGN, MPDZ, PRKCH, MYH14, MYH7B, EPB41L3, PRKCZ, CRB3, JAM3",0.549750891680639,0.182434630440219,FALSE +"HCC44","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.2275,-0.664,0.89,7099,0.956,"PIK3CA, AKT2, MAPK13, MAPK1, SPP1, MAPK3, MAPK12, TOLLIP, CASP8, FADD, STAT1, IL6, MAP2K6, IFNAR1, PIK3CD, TLR3",0.0506099933550872,0.0195421077238999,FALSE +"HCC44","Input","KEGG_TRYPTOPHAN_METABOLISM",0.28792,0.914,0.506,925,0.767,"KYNU, ALDH2, EHHADH, WARS2",0.295849483160201,0.115204636051019,FALSE +"HCC44","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.48482,-1.41,0.106,6047,0.622,"PKLR, MAPK10, PKM, IKBKB, PIK3R1, PIK3R2, IRS1, INSR, PIK3CA, MAPK1, MAPK3, HK1, PRKCD, PIK3CD, PRKCZ",0.97469413473523,0.206209615309181,FALSE +"HCC44","Input","KEGG_TYROSINE_METABOLISM",-0.42058,-1.22,0.223,7308,0.636,"ALDH3A1, LCMT1, MAOB, MAOA, TAT, DDC, ADH4, ADH7, ADH5",0.651695136951839,0.196542884351586,FALSE +"HCC44","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.45108,-1.32,0.158,7081,0.608,"NFATC2, PIK3CA, RAF1, PPP3CC, TEC, PRKCQ, AKT2, PAK4, MAPK13, MAPK1, VAV2, MAPK3, MAPK12, NFKBIE, GRB2, PTPN6, PLCG1, SOS1, VAV3, PDPK1, PTPRC, NCK2, PAK5, PAK6, GSK3B, PIK3CD, PPP3R1",0.801342913045577,0.216096420727265,FALSE +"HCC44","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.23239,-0.672,0.884,5967,0.956,"CUL5, UBA2, ANAPC7, UBE2D2, TRIM37, CUL4B, FBXW11, UBE2G1, DDB2, UBE2F, MAP3K1, UBE2J1, CUL3, UBE4B, FBXO2, NHLRC1, BTRC, UBA1, DDB1, SKP1, ANAPC4, COP1, FZR1, CDC20, UBE2R2, CUL7, HERC1, FBXW7, SMURF2, KEAP1, PIAS1, MGRN1, KLHL13, UBE2C",0.0535477349869269,0.0195421077238999,FALSE +"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.28336,-0.848,0.633,7143,0.808,"IARS2, BCAT2",0.198596289982645,0.0925886392254138,FALSE +"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.21887,-0.649,0.894,8659,0.963,"ACADS, ABAT, HMGCS1",0.0486624812040823,0.0163737128754655,FALSE +"HCC44","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.27061,-0.776,0.726,7010,0.861,"GNA13, PLCB2, GNAQ, RAF1, PRKCQ, ADCY9, PLCB3, MAPK1, ARHGEF12, MAPK3, GNA11, GNA12, KCNMA1, NPR2, ARHGEF11, PRKCD, CALM2, PRKCH, CALML3, PLCB4",0.139063379299906,0.0649968485463452,FALSE +"HCC44","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.39997,-1.18,0.221,6986,0.679,"DYNLL2, DYNLL1, ADCY9, RAB5B, RAB11A, AVP, AQP3, ARHGDIB",0.655607726314889,0.168130225719498,FALSE +"HCC44","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.30469,0.959,0.424,170,0.735,"RAC2, PTGS2, PLA2G4A, VEGFA",0.372634143407267,0.133712660915805,FALSE +"HCC44","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.25372,-0.739,0.772,6568,0.895,"KDELR3, ATP6V0D1, ATP6V1B2, ATP6V1A, ATP6V1E1, ATP6V1B1, ATP6V0A1, ATP6V1C2, ADCY9, ATP6V1H, ATP6V1F, ATP6V1C1, ATP6V1D, PLCG1, SLC12A2, PLCG2",0.112382699664264,0.048176964684088,FALSE +"HCC44","Input","KEGG_VIRAL_MYOCARDITIS",0.46775,1.45,0.104,670,0.402,"RAC2, ITGB2, ICAM1, CD40, MYH11, MYH9, LAMA2, CD55",0.98296666070122,0.39577394691553,FALSE +"HCC44","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.31185,-0.916,0.506,6099,0.741,"DVL3, CTBP1, MAPK10, SMAD2, FBXW11, AXIN1, PPP3CB, ROCK1, PPP2R5C, CHD8, MAP3K7, PPP2CA, EP300, PPP2R5E, PLCB1, APC, WNT5A, PPP2R5A, BTRC, CSNK1E, PPP2R5D, FZD1, PLCB2, NFATC2, PPP2R5B, PPP3CC, CAMK2B, CREBBP, WNT11, PLCB3, LRP6, TCF7L2, SKP1, TCF7L1, VANGL1, CCND1, CAMK2D, FZD6, DAAM1, CSNK1A1, CTNNB1, GSK3B, RAC3, VANGL2, PPP3R1, TP53, PLCB4, LEF1",0.295849483160201,0.130181792020672,FALSE +"H1299","Input","KEGG_ABC_TRANSPORTERS",-0.27599,-0.866,0.601,8317,0.753,"ABCG2, ABCB6, ABCD3, ABCA2, ABCC2",0.22112552799726,0.123205023799299,FALSE +"H1299","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.24869,-0.795,0.722,6104,0.86,"PIK3R2, RUNX1, KRAS, NRAS, KIT, PIK3R3, BRAF, MAPK3, GRB2, SOS1, STAT3, HRAS, STAT5A, TCF7L2, RPS6KB2, PIM1, TCF7L1, PIK3CD, CCND1, LEF1, CEBPA",0.141462802430361,0.0655015487564323,FALSE +"H1299","Input","KEGG_ADHERENS_JUNCTION",-0.40719,-1.28,0.163,7299,0.344,"RAC1, PARD3, IGF1R, TCF7L2, WASF2, SRC, SORBS1, CREBBP, TCF7L1, EP300, LMO7, INSR, LEF1, ERBB2, PTPRM, ACTG1, BAIAP2, PTPN6, CTNNB1, CTNND1, NECTIN1, CTNNA1, CTNNA2, RAC2, CDH1",0.787812395596042,0.46344155742847,FALSE +"H1299","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.34377,-1.1,0.308,8606,0.471,"IRS2, CAMKK1, ACSL1, NFKBIA, RXRG, RXRA, ACSL5, PRKCQ",0.511449283499556,0.326979092871104,FALSE +"H1299","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.512,-1.6,0.0677,8299,0.186,"GFPT1, GLUL, CPS1, ABAT, ASS1, GLUD2",1.16941133131486,0.730487055782084,FALSE +"H1299","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.47784,-1.48,0.0829,7168,0.24,"ATP1A3, PDPK1, SFN, ATP1A1, SLC9A3R2, ATP1B3, ATP1A4, PIK3CD, ATP1B1, INSR, IRS2, HSD11B2",1.08144546944973,0.619788758288394,FALSE +"H1299","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.73163,-2.35,0,8416,0.0459,"PLA2G12A, ACOX1, PLA2G4A, FADS2",Inf,1.33818731446274,TRUE +"H1299","Input","KEGG_ALZHEIMERS_DISEASE",0.18642,0.584,0.958,3800,1,"TNFRSF1A, PLCB4, CYC1, BAD, COX6C, NDUFA9, PSEN1, CYCS, NDUFB4, UQCRQ, MME, GAPDH, NDUFS2, CAPN2, CHP1, NDUFB7, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, NDUFA4, NDUFC2, ITPR1, PPP3CC, NDUFS3, UQCRFS1, CASP3, NDUFA5, NDUFA2, ATP5PO, NDUFA6, NDUFA10, COX4I1, COX6B1, ITPR2, ATP5PB, NDUFB10, NDUFB9, GRIN1, NCSTN, SDHD, COX5A, ADAM17, UQCRC2, FADD, APAF1, NDUFB2, CASP9, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB",0.0186344909214556,0,FALSE +"H1299","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.35339,1.12,0.27,1225,0.938,"RARS2, DARS2, YARS2, AARS2",0.568636235841013,0.0277971616209356,FALSE +"H1299","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.26716,-0.841,0.638,7688,0.786,"GMPPA, UGDH, GMDS, HK1, CYB5R1, GFPT1, PGM1, MPI, UXS1, GALT, PMM2, GALE",0.195179321278838,0.104577453960592,FALSE +"H1299","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.34158,1.08,0.313,1049,0.891,"NEFH, TNFRSF1A, PRPH, PRPH2, MAP2K3, TOMM40, BAD, NEFM, DAXX, CYCS",0.504455662453552,0.0501222959631252,FALSE +"H1299","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.31939,-0.994,0.423,7289,0.593,"PSME2, CREB1, CTSB, B2M, PDIA3, PSME1, CANX, CD74, CALR, CTSS, IFI30",0.373659632624958,0.226945306635737,FALSE +"H1299","Input","KEGG_APOPTOSIS",0.20589,0.646,0.912,1231,1,"TNFRSF1A, RIPK1, TNFRSF10A, IRAK4, BIRC2, ENDOG, BAD, EXOG, CYCS, AKT1, IRAK1",0.0400051616715838,0,FALSE +"H1299","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.64437,-2.03,0.00374,8030,0.0989,"CBR1, GPX2, ALOX5, GGT1, PLA2G12A, GPX6, GPX7, CYP2J2, PTGS2, PTGES, PLA2G4A, EPHX2, GPX1",2.42712839779952,1.00480370840282,TRUE +"H1299","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.54637,-1.73,0.0409,7582,0.138,"MAOA, ALDH18A1, PYCR3, OAT, ALDH3A2, GAMT, CKMT2, GLUL, PYCR1, PYCR2, AGMAT, GATM, ARG2, P4HA2, P4HA1, ALDH2, ARG1, MAOB, CPS1, ALDH1B1, ASS1, GLUD2",1.38827669199266,0.860120913598763,TRUE +"H1299","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.37732,-1.18,0.227,8316,0.401,"ITGAV, LEF1, ACTG1, DSG2, ITGA7, PKP2, CTNNB1, ITGB4, GJA1, DSC2, CTNNA1, SGCD, CTNNA2, ITGB6",0.643974142806877,0.396855627379818,FALSE +"H1299","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.74763,-2.33,0.00184,7164,0.0408,"ALDH9A1, UGDH, ALDH3A2, ALDH2, ALDH1B1",2.73518217699046,1.38933983691012,TRUE +"H1299","Input","KEGG_AXON_GUIDANCE",-0.4094,-1.27,0.177,8174,0.35,"PLXNB1, DPYSL2, PLXNB2, SEMA7A, SEMA4D, EPHB2, SEMA3A, EFNB2, EPHA1, UNC5B, SEMA6A, EPHA4, L1CAM, RAC2, ABLIM1, ABLIM3, PLXNA2, ABLIM2",0.752026733638193,0.455931955649724,FALSE +"H1299","Input","KEGG_BASAL_CELL_CARCINOMA",-0.64483,-2.04,0.00929,7556,0.103,"TCF7L2, FZD7, GSK3B, APC, TCF7L1, SHH, LEF1, WNT16, CTNNB1, SUFU, TP53, WNT11",2.03198428600636,0.987162775294828,TRUE +"H1299","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.23949,0.773,0.752,3786,1,"TAF2, TBP, GTF2I, TAF9B, GTF2A1, GTF2H4, GTF2A2, TAF6, TAF1, TAF5, TAF13",0.123782159408358,0,FALSE +"H1299","Input","KEGG_BASE_EXCISION_REPAIR",-0.37405,-1.17,0.24,7169,0.398,"SMUG1, XRCC1, FEN1, NTHL1, LIG1, APEX1, MPG, APEX2, LIG3, PARP1, TDG",0.619788758288394,0.400116927926312,FALSE +"H1299","Input","KEGG_BETA_ALANINE_METABOLISM",-0.58082,-1.9,0.0165,7164,0.102,"ALDH9A1, SRM, EHHADH, HIBCH, ALDH3A2, ALDH2, ABAT, ALDH1B1",1.78251605578609,0.991399828238082,TRUE +"H1299","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.28374,0.888,0.557,786,1,"ELOVL2, ELOVL5, HACD1, ACOX3",0.254144804826271,0,FALSE +"H1299","Input","KEGG_BLADDER_CANCER",-0.35677,-1.1,0.29,8433,0.471,"CCND1, THBS1, ERBB2, TP53, CDH1",0.537602002101044,0.326979092871104,FALSE +"H1299","Input","KEGG_BUTANOATE_METABOLISM",-0.60337,-1.86,0.0221,8426,0.111,"HMGCS2, BDH2, HMGCS1, ACADS, BDH1, ALDH2, ABAT, ALDH1B1, ACSM3",1.65560772631489,0.954677021213343,TRUE +"H1299","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.31263,-0.995,0.407,7871,0.598,"GSK3B, PIK3AP1, PIK3CD, BTK, PTPN6, SYK, NFKBIA, CD81, INPP5D, RAC2",0.39040559077478,0.223298816011589,FALSE +"H1299","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.33568,-1.06,0.345,6674,0.516,"PPP3CB, CALML3, PHKA2, GNAS, ERBB4, CAMK2D, CAMK2G, ATP2B1, ADCY9, GNA11, ATP2A3, GNAQ, SLC25A4, PRKACB, ITPKB, LTB4R2, PTK2B, P2RX4, ATP2B2, ATP2B4, ERBB2, BST1, ERBB3, MYLK, PLCB1, TNNC1, CACNA1A, TNNC2",0.462180904926726,0.287350298372789,FALSE +"H1299","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.36738,1.16,0.265,755,0.949,"TPM2, SLC8A1, CACNA2D1, SLC9A6, CYC1, COX6C",0.576754126063192,0.0227337875727074,FALSE +"H1299","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.53518,-1.71,0.0519,8105,0.136,"CD58, NEO1, VCAM1, CD274, ITGAV, ITGB2, PTPRM, F11R, CNTN1, SDC3, NECTIN1, CLDN3, SDC1, CLDN4, CLDN6, ALCAM, L1CAM, CD276, SDC2, CDH1, NRCAM, CD99, CADM1, CDH15, CDH3, ICAM2, CLDN7",1.28483264215154,0.866461091629782,FALSE +"H1299","Input","KEGG_CELL_CYCLE",0.33724,1.09,0.307,3160,0.966,"TGFB1, ESPL1, TTK, CDK6, CDK1, BUB1, CCNB1, PRKDC, ANAPC4, ORC3, ANAPC5, ORC4, CDC20, DBF4, CDC45, ORC5, CDC16, YWHAZ, CCNB2, ORC1, MYC, CHEK1, CDC27, ORC2, ANAPC1, PLK1, CDK7, ANAPC7, CDC23, MAD2L2, MCM7, SMC3, ANAPC2, YWHAB, MCM2, SMC1A, MAD1L1, YWHAQ, ANAPC10, CDC25C, SMC1B, CUL1, BUB1B, MCM6, MCM4, MCM5, RB1, SMAD3, TGFB2",0.512861624522813,0.0150228735845067,FALSE +"H1299","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.31113,-0.977,0.431,6212,0.61,"KRAS, NRAS, PIK3R3, BRAF, CCR4, GNB2, MAPK3, GNG2, RHOA, ARRB2, STAT2, GRB2, GNB1, GNB4, SOS1, STAT3, CCL13, HRAS, WASL, ADCY9, CCL15, RAC1, PARD3, GNG10, VAV2, PREX1, PRKACB, GSK3B, STAT1, GNB3, PIK3CD, ELMO1, PTK2B, GRK2, PRKCD, NFKBIA, ADCY5, PLCB1, CCL20, RAC2, ARRB1",0.365522729839268,0.214670164989233,FALSE +"H1299","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.19833,0.637,0.936,1929,1,"TGFB1, CDK6, CBL, BAD, AKT1, MYC, MECOM, SHC1, AKT2, CRK, AKT3",0.0287241512618947,0,FALSE +"H1299","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.36967,-1.16,0.246,7037,0.406,"IDH3G, DLAT, SUCLA2, ACO2, ACLY, PCK2, SUCLG2, MDH1, SUCLG1, PC, IDH1, IDH2",0.609064892896621,0.391473966422806,FALSE +"H1299","Input","KEGG_COLORECTAL_CANCER",-0.20836,-0.664,0.872,7871,0.969,"GSK3B, APC, TCF7L1, PIK3CD, CCND1, LEF1, CTNNB1, TP53, RAC2",0.0594835150674328,0.0136762229492347,FALSE +"H1299","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.43013,-1.35,0.134,7894,0.301,"F8, SERPING1, C5, PROC, CD46, FGA, FGG, TFPI, FGB, PLG, F3, PROS1, SERPINA1, CD55, SERPINF2, A2M, C4A, SERPINC1",0.872895201635192,0.521433504406157,FALSE +"H1299","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.26869,0.847,0.59,1334,1,"LDHB, CBS, DNMT1, SDS, CDO1, GOT1, SMS",0.229147988357856,0,FALSE +"H1299","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.21322,0.683,0.88,605,1,"TGFB1, TNFRSF1A, CD70, TNFRSF10A, OSMR",0.0555173278498314,0,FALSE +"H1299","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.30925,-0.961,0.46,8812,0.619,"NFKBIA, IL6, TREX1, IL18, PYCARD",0.337242168318426,0.208309350979882,FALSE +"H1299","Input","KEGG_DILATED_CARDIOMYOPATHY",0.39562,1.26,0.202,211,0.884,"TGFB1, ITGA4, TPM2, SLC8A1, ITGA3, DES, CACNA2D1",0.694648630553376,0.0535477349869269,FALSE +"H1299","Input","KEGG_DNA_REPLICATION",0.41963,1.35,0.134,3133,0.812,"PRIM1, PRIM2, POLA1, POLE, POLA2, POLE2, DNA2, RFC3, POLE3, RFC2, RFC5, RFC4, MCM7, MCM2, RNASEH2A, MCM6, MCM4, MCM5, RFC1",0.872895201635192,0.0904439707588247,FALSE +"H1299","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.26076,0.831,0.618,6901,1,"ETS1, EGFR, NOTCH2, MAPK1, MAP2K1, ETV6, NOTCH3, NOTCH1, KRAS, MAPK3, GRB2, SOS1",0.209011524911184,0,FALSE +"H1299","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.61305,-1.93,0.0165,8247,0.101,"GSTM3, CYP3A5, ALDH3A1, MGST3, GSTM4, GSTP1, MAOB, GSTM1, ALDH1A3, MGST1, GSTZ1, GSTT2",1.78251605578609,0.995678626217357,TRUE +"H1299","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.33138,-1.04,0.381,8546,0.54,"CYP3A5, CES1, CES2, CDA",0.419075024324381,0.267606240177031,FALSE +"H1299","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.54823,-1.73,0.0221,8277,0.138,"THBS4, COL2A1, ITGAV, THBS1, LAMA3, LAMA4, LAMA1, HSPG2, COL6A3, ITGA7, VTN, SDC3, ITGB4, COL5A1, LAMA5, COL1A2, LAMB1, TNC, COL1A1, COL4A1, COL3A1, AGRN, COL5A2, FN1, SDC1, SDC2, ITGB6, COL4A2",1.65560772631489,0.860120913598763,TRUE +"H1299","Input","KEGG_ENDOCYTOSIS",-0.24244,-0.76,0.79,6194,0.885,"IQSEC1, KIT, HSPA2, ARAP1, ACAP3, IQSEC2, CHMP3, NEDD4L, FGFR3, ARRB2, EHD3, ARFGAP2, PIP5K1C, AP2S1, PRKCI, AGAP2, ERBB4, RAB11FIP5, CHMP2A, CLTCL1, SH3GL2, PIP4K2B, SH3GLB2, SMAP2, HRAS, EPS15, PARD3, STAM, AGAP1, IGF1R, CHMP4A, CHMP4B, STAMBP, RAB22A, RAB11FIP4, AP2A1, FGFR4, RAB5C, CBLB, SRC, LDLRAP1, CHMP4C, CHMP2B, GIT1, DAB2, DNAJC6, ARF6, EPN1, PARD6G, GRK2, ERBB3, PARD6B, DNM1, RAB11FIP1, ARRB1",0.102372908709559,0.0530567293021746,FALSE +"H1299","Input","KEGG_ENDOMETRIAL_CANCER",-0.42658,-1.35,0.129,7871,0.301,"GSK3B, APC, TCF7L1, PIK3CD, CCND1, LEF1, ERBB2, CTNNB1, CTNNA1, CTNNA2, TP53, CDH1",0.889410289700751,0.521433504406157,FALSE +"H1299","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.22248,-0.687,0.87,6283,0.963,"ADAM10, ATP6V0A1, ATP6V1G1, ATP6V0C, ATP6AP1, PLCG2, ATP6V1E1, MAPK8, TJP1, ATP6V1F, RAC1, ATP6V1C2, ATP6V0D1, SRC, GIT1, ATP6V0D2, F11R, NFKBIA, MAPK13",0.0604807473813815,0.0163737128754655,FALSE +"H1299","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.18053,-0.574,0.966,6212,0.98,"KRAS, NRAS, PIK3R3, BRAF, MAPK3, PLCG2, MAPK8, GRB2, SOS1, MAP2K7, ERBB4, CAMK2D, CAMK2G, HRAS, NCK2, STAT5A, GAB1, ABL2, RPS6KB2, CBLB, GSK3B, SRC, EREG, PIK3CD, ERBB2, ERBB3, AREG",0.0150228735845067,0.00877392430750515,FALSE +"H1299","Input","KEGG_ETHER_LIPID_METABOLISM",-0.50311,-1.6,0.0473,8097,0.186,"PAFAH2, PLA2G12A, LPCAT2, PLA2G4A, PLPP3",1.32513885926219,0.730487055782084,TRUE +"H1299","Input","KEGG_FATTY_ACID_METABOLISM",-0.38803,-1.21,0.205,7905,0.38,"ALDH3A2, CPT2, GCDH, ACOX1, ACAA1, ACADS, ACSL1, ALDH2, ALDH1B1, ACSL5",0.688246138944246,0.42021640338319,FALSE +"H1299","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.43435,-1.38,0.124,8251,0.297,"PIK3CD, PLA2G12A, BTK, SYK, PRKCD, PLA2G4A, MAPK13, INPP5D, RAC2, MAP2K6",0.906578314837765,0.527243550682788,FALSE +"H1299","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.36011,-1.13,0.289,8251,0.44,"PIK3CD, ARF6, MARCKSL1, MARCKS, DNM1, SYK, PRKCD, SCIN, PLA2G4A, PLPP3, AMPH, INPP5D, RAC2",0.539102157243452,0.356547323513813,FALSE +"H1299","Input","KEGG_FOCAL_ADHESION",-0.30779,-0.969,0.451,8251,0.611,"PIK3CD, THBS4, COL2A1, ITGAV, ARHGAP5, MYL9, FLNB, CCND1, THBS1, LAMA3, LAMA4, ERBB2, LAMA1, ACTG1, MYLK, COL6A3, ITGA7, VTN, CTNNB1, ITGB4, COL5A1, LAMA5, COL1A2, LAMB1, TNC, COL1A1, COL4A1, COL3A1, COL5A2, FN1, ITGB6, RAC2, COL4A2",0.345823458122039,0.213958789757446,FALSE +"H1299","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.55745,-1.76,0.0378,8870,0.142,"QDPR, ALPI, ALPP",1.42250820016277,0.847711655616944,TRUE +"H1299","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.55361,-1.72,0.0333,6901,0.139,"PFKL, PFKM, GMPPB, ALDOA, PFKFB3, PFKFB2, GMPPA, AKR1B1, GMDS, HK1, KHK, MPI, PFKFB4, ALDOC, PMM2",1.47755576649368,0.856985199745905,TRUE +"H1299","Input","KEGG_GALACTOSE_METABOLISM",-0.54319,-1.67,0.0341,6901,0.154,"PFKL, PFKM, GANC, AKR1B1, HK1, GLB1, PGM1, GALT, GALE, GAA, B4GALT1",1.4672456210075,0.812479279163537,TRUE +"H1299","Input","KEGG_GAP_JUNCTION",-0.19341,-0.616,0.942,6756,1,"GRB2, GNAS, SOS1, TJP1, TUBAL3, HRAS, ADCY9, GUCY1A1, GNA11, GNAQ, PRKACB, SRC, ADCY5, GJA1, PLCB1, TUBA4A",0.0259490972071227,0,FALSE +"H1299","Input","KEGG_GLIOMA",-0.18458,-0.577,0.962,6104,0.986,"PIK3R2, KRAS, NRAS, PIK3R3, BRAF, MAPK3, PLCG2, CALML3, GRB2, SOS1, CAMK2D, CAMK2G, HRAS, IGF1R, CDK4, PIK3CD, CCND1, TP53",0.0168249279621871,0.0061230850587888,FALSE +"H1299","Input","KEGG_GLUTATHIONE_METABOLISM",-0.55513,-1.73,0.0399,8136,0.138,"G6PD, GPX2, GSTM3, GGT1, GPX6, GPX7, GSR, MGST3, GSTM4, GSTP1, IDH1, GSTM1, MGST1, GSTZ1, GSTT2, IDH2, GPX1",1.39902710431325,0.860120913598763,TRUE +"H1299","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.42507,-1.34,0.151,6839,0.306,"DGKA, AGPAT2, TKFC, ALDH9A1, CEL, DGKD, DGKZ, AKR1B1, ALDH3A2, LIPG, ALDH2, MGLL, PLPP3, LIPC, LPL, AKR1A1, ALDH1B1",0.821023052706831,0.51427857351842,FALSE +"H1299","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.27765,-0.865,0.616,6836,0.747,"PTDSS1, DGKA, MBOAT7, AGPAT2, CHKB, CDS1, GPD1L, LYPLA2, CDIPT, CDS2, CHKA, DGKD, DGKZ, LPGAT1, PEMT, GNPAT, PLA2G12A, LPCAT2, PLA2G4A, PLPP3",0.210419287835575,0.126679398184601,FALSE +"H1299","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.38232,-1.18,0.253,6692,0.401,"PSPH, SHMT1, SHMT2, AGXT, MAOA, GCAT, PHGDH, SRR, GAMT, SARDH, CTH, GATM, CHDH, MAOB",0.596879478824182,0.396855627379818,FALSE +"H1299","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.39076,-1.24,0.181,6901,0.352,"PFKL, PFKM, ACSS2, DLAT, ALDH9A1, BPGM, ALDOA, GALM, PGAM2, PCK2, ALDH3A2, HK1, LDHA, PGM1, ALDH3A1, ACSS1, ALDOC, ALDH2, ALDH1A3, AKR1A1, ALDH1B1",0.742321425130815,0.453457336521869,FALSE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.4068,-1.3,0.161,7049,0.338,"CHST11, B3GAT3, CHPF, CHST13, CHST12, XYLT1",0.79317412396815,0.471083299722345,FALSE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.40611,-1.29,0.178,8371,0.344,"GLCE, XYLT1, HS6ST2",0.749579997691106,0.46344155742847,FALSE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.76407,-2.45,0,7570,0.0398,"B4GALT3, B4GAT1, B3GNT2, ST3GAL1, B4GALT4, B4GALT1",Inf,1.40011692792631,TRUE +"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.33106,-1.06,0.344,7666,0.516,"IDS, IDUA, GLB1, HGSNAT, NAGLU",0.46344155742847,0.287350298372789,FALSE +"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.41618,-1.32,0.139,8864,0.322,"ST3GAL1",0.856985199745905,0.492144128304169,FALSE +"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.74034,-2.36,0.00177,7570,0.0569,"B4GALT3, B4GAT1, B3GNT3, B3GNT2, ST3GAL6, ST3GAL4, B4GALT4, B4GALT1",2.75202673363819,1.24488773360493,TRUE +"H1299","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.19378,-0.61,0.952,7000,0.998,"PIGO, PIGU, PIGS, PIGQ",0.0213630516155257,0.000869458712628891,FALSE +"H1299","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.4821,1.54,0.0872,1618,0.659,"MTHFD1L, MTHFD2L, HYI, MTHFD2, MDH2, CS",1.05948351506743,0.18111458540599,FALSE +"H1299","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.31871,-1.03,0.395,6707,0.55,"CALML3, MAPK8, GRB2, GNAS, SOS1, MAP2K7, CAMK2D, CAMK2G, HRAS, ADCY9, GNA11, GNAQ, PRKACB, MAP3K1, SRC, MMP14, PTK2B, PLA2G12A, PRKCD, ADCY5, PLCB1, PLA2G4A, MAPK13, MAP2K6",0.40340290437354,0.259637310505756,FALSE +"H1299","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.64355,-2.01,0.0148,7408,0.0872,"CSNK1E, PRKACB, GSK3B, SHH, WNT16, SUFU, WNT11",1.82973828460504,1.05948351506743,TRUE +"H1299","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.4814,1.52,0.0808,1229,0.605,"ITGA4, ITGA3, CD44, ANPEP, CD59, ITGA6, ITGA5, MME, CD9",1.09258863922541,0.218244625347531,FALSE +"H1299","Input","KEGG_HISTIDINE_METABOLISM",-0.58082,-1.83,0.0149,7582,0.117,"MAOA, ALDH3A2, HNMT, DDC, ALDH3A1, ALDH2, MAOB, ALDH1A3, ALDH1B1",1.82681373158773,0.931814138253838,TRUE +"H1299","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.51928,1.68,0.0523,1324,0.488,"RAD51C, RAD52, SEM1, TOP3A, BLM, RAD50, NBN, MRE11",1.28149831113273,0.311580177997289,FALSE +"H1299","Input","KEGG_HUNTINGTONS_DISEASE",0.16839,0.547,0.982,4015,1,"PLCB4, CYC1, COX6C, NDUFA9, POLR2B, CYCS, NDUFB4, UQCRQ, TBP, NDUFS2, DLG4, POLR2K, NDUFB7, POLR2A, RCOR1, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, TGM2, TFAM, POLR2G, HIP1, DCTN1, NDUFA4, NDUFC2, ITPR1, GRM5, NDUFS3, UQCRFS1, CASP3, NDUFA5, NDUFA2, DCTN2, ATP5PO, NDUFA6, NDUFA10, COX4I1, COX6B1, POLR2E, POLR2I, ATP5PB, NDUFB10, NDUFB9, GRIN1, SDHD, COX5A, POLR2J, UQCRC2, POLR2C, SIN3A, IFT57, HDAC2, APAF1, NDUFB2, CASP9, CLTC, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB, SLC25A31, NDUFV1, ATP5F1A, HTT, DCTN4, UQCRH, VDAC2, ATP5F1C",0.00788851221305034,0,FALSE +"H1299","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.38084,1.24,0.21,211,0.863,"TGFB1, ITGA4, TPM2, SLC8A1, ITGA3, DES, CACNA2D1",0.677780705266081,0.0639892042847904,FALSE +"H1299","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.30975,0.97,0.427,999,1,"ISYNA1, IMPA1, PLCB4, SYNJ2, SYNJ1, INPP5K, INPP4B",0.369572124974976,0,FALSE +"H1299","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.21631,-0.684,0.863,5890,0.959,"CALM2, CRKL, PPP1CB, PPP1R3D, IKBKB, PTPRF, PIK3R2, PHKG2, KRAS, NRAS, HK2, PHKB, PIK3R3, PRKAR2B, HK3, BRAF, PYGB, MAPK3, CALML3, MAPK8, PRKCI, PHKA2, GRB2, SOS1, PRKAR1A, PRKAR1B, HRAS, PYGL, EXOC7, PDPK1, FLOT1, PDE3A, PCK2, RPS6KB2, CBLB, PRKACB, GSK3B, MKNK1, FOXO1, HK1, SORBS1, FLOT2, PRKAA2, PIK3CD, INSR, IRS2, GYS1, INPP5D",0.0639892042847904,0.0181813928293364,FALSE +"H1299","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.59836,1.9,0.0156,49,1,"TGFB1, ITGA4",1.80687540164554,0,FALSE +"H1299","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.22286,-0.693,0.861,6637,0.962,"STAT2, LIFR, GRB2, SOS1, STAT3, IFNAR1, STAM, STAT5A, PIM1, CBLB, STAT1, CREBBP, IL13RA1, EP300, PIK3CD, CCND1, IRF9, PTPN6, STAT6, IL6",0.0649968485463452,0.0168249279621871,FALSE +"H1299","Input","KEGG_LEISHMANIA_INFECTION",0.30283,0.979,0.466,536,1,"TGFB1, ITGA4, JUN, MAP3K7, IRAK4",0.33161408331,0,FALSE +"H1299","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.3717,-1.17,0.242,8232,0.398,"VCAM1, PIK3CD, ARHGAP5, MYL9, PTK2B, ITGB2, F11R, ACTG1, CTNNB1, CTNND1, CLDN3, CTNNA1, CLDN4, CTNNA2, CLDN6, MAPK13, RAC2, CD99, CLDN7",0.616184634019569,0.400116927926312,FALSE +"H1299","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.65603,-2.06,0.00719,7164,0.105,"ALDH9A1, EHHADH, ALDH3A2, ALDH2, ALDH1B1",2.14327110961712,0.978810700930062,TRUE +"H1299","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.79212,-2.53,0,8416,0.041,"PLA2G12A, CYP3A5, CYP2J2, PLA2G4A",Inf,1.38721614328026,TRUE +"H1299","Input","KEGG_LONG_TERM_DEPRESSION",-0.31337,-0.975,0.426,6212,0.607,"KRAS, NRAS, BRAF, PLA2G12B, MAPK3, RYR1, GUCY1B1, GNAS, HRAS, GUCY1A1, GNA11, IGF1R, GNAQ, GNA13, PLA2G12A, GNAO1, PLCB1, CACNA1A, PLA2G4A",0.370590400897281,0.216811308924742,FALSE +"H1299","Input","KEGG_LONG_TERM_POTENTIATION",0.15912,0.513,0.991,199,1,"ATF4, PLCB4",0.00392634551472468,0,FALSE +"H1299","Input","KEGG_LYSINE_DEGRADATION",-0.19376,-0.612,0.951,7905,1,"ALDH3A2, GCDH, PLOD1, PLOD2, ALDH2, ALDH1B1",0.0218194830625861,0,FALSE +"H1299","Input","KEGG_LYSOSOME",-0.39391,-1.25,0.191,7548,0.345,"LAMP1, CTSB, IDS, IDUA, GNPTAB, ATP6V0D1, PPT1, GNPTG, GGA2, SORT1, GM2A, AP1M2, AP3S2, GLB1, CTSZ, LAMP2, GBA, NAPSA, ATP6V0D2, SUMF1, ABCA2, FUCA1, ENTPD4, CTSS, SCARB2, HGSNAT, SLC11A2, ASAH1, NAGLU, GAA, ARSA, CTSH",0.718966632752272,0.462180904926726,FALSE +"H1299","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.26656,0.817,0.652,445,1,"TGFB1, FLNC, RELB, FGF13, FGF2, ATF4, TNFRSF1A, NFKB2, CACNA2D1, FGFR1, MAP2K3, JUN, MAP3K7",0.18575240426808,0,FALSE +"H1299","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.63279,-2.02,0.00361,7212,0.0958,"HES1, HNF1B, MNX1, IAPP, NEUROD1, HNF1A, HNF4A, FOXA2",2.44249279809434,1.01863449092146,TRUE +"H1299","Input","KEGG_MELANOGENESIS",-0.50213,-1.58,0.0615,7032,0.189,"CAMK2D, CAMK2G, HRAS, ADCY9, CREB1, ASIP, TCF7L2, GNAQ, FZD7, PRKACB, GSK3B, CREBBP, KITLG, TCF7L1, EP300, LEF1, GNAO1, DCT, WNT16, CREB3L2, CTNNB1, ADCY5, MITF, TYRP1, PLCB1, WNT11",1.21112488422458,0.723538195826756,FALSE +"H1299","Input","KEGG_MELANOMA",0.32989,1.07,0.314,235,0.872,"FGF13, FGF2, CDK6, FGFR1",0.503070351926785,0.0594835150674328,FALSE +"H1299","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.59808,-1.88,0.0199,8139,0.108,"CYP1B1, GSTM3, CYP3A5, ALDH3A1, MGST3, GSTM4, GSTP1, CYP2S1, EPHX1, GSTM1, ALDH1A3, MGST1, GSTZ1, GSTT2",1.70114692359029,0.96657624451305,TRUE +"H1299","Input","KEGG_MISMATCH_REPAIR",0.25847,0.838,0.674,3817,1,"RFC3, RFC2, RFC5, PMS2, RFC4, MSH3, RFC1, MSH6, RPA2, SSBP1, MSH2",0.17134010346468,0,FALSE +"H1299","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.15967,0.511,0.989,2192,1,"ULK1, AKT1, ULK3, RICTOR, RPS6KB1, AKT2, AKT3, RPTOR, RPS6, PRKAA1, MTOR",0.0048037084028206,0,FALSE +"H1299","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.23437,-0.728,0.81,6099,0.923,"PPP3CA, PIK3R2, KRAS, NRAS, IFNAR2, PIK3R3, BRAF, TNFRSF10B, MAPK3, BID, PLCG2, PPP3CB, GRB2, TNFRSF10D, SOS1, IFNAR1, RAET1L, ULBP2, HRAS, RAC1, VAV2, PIK3CD, LCK, PTK2B, ITGB2, PTPN6, SYK, RAC2, ICAM2",0.0915149811213502,0.0347982989740879,FALSE +"H1299","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.23196,-0.726,0.809,6550,0.918,"F2, TSPO, PARD3, LTB4R2, PLG, P2RX4",0.0920514783877277,0.0371573187987575,FALSE +"H1299","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.21115,-0.678,0.864,6212,0.959,"KRAS, NRAS, MAP3K3, PIK3R3, RPS6KA6, ARHGDIA, BRAF, MAPK3, RHOA, PLCG2, RPS6KA3, YWHAH, CALML3, MAPK8, BAX, GRB2, SOS1, MAP2K7, CAMK2D, CAMK2G, HRAS, MAP3K5, RAC1, RPS6KA5, PDPK1, GAB1, MAPKAPK2, RPS6KA4, MAP3K1, GSK3B, SORT1, RPS6KA2, ARHGDIB, PIK3CD, RPS6KA1, IRS2, PRKCD, NFKBIA, MAPK13, NGFR, TP53",0.0634862575211067,0.0181813928293364,FALSE +"H1299","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.50481,-1.56,0.0524,8445,0.193,"PNP, BST1, NNMT, NNT, NUDT12, QPRT",1.28066871301627,0.714442690992226,FALSE +"H1299","Input","KEGG_NITROGEN_METABOLISM",-0.43691,-1.4,0.119,7711,0.283,"CA2, CA5B, CA12, GLUL, CTH, CPS1, GLUD2",0.924453038607469,0.54821356447571,FALSE +"H1299","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.28592,-0.906,0.528,8812,0.699,"NFKBIA, IL6, IL18, MAPK13, PYCARD",0.277366077466188,0.155522824254319,FALSE +"H1299","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.4647,1.48,0.0933,1324,0.603,"PRKDC, RAD50, MRE11",1.0301183562535,0.219682687859849,FALSE +"H1299","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.25345,-0.795,0.7,8251,0.86,"PIK3CD, CCND1, ERBB2, FHIT, RXRG, RXRA, TP53",0.154901959985743,0.0655015487564323,FALSE +"H1299","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.28057,-0.878,0.583,7134,0.737,"NCOR2, MAML2, HES1, CTBP2, CREBBP, EP300, DTX3L, JAG1, JAG2",0.234331445240986,0.132532512140949,FALSE +"H1299","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.21893,0.691,0.846,2833,1,"POLE, POLE2, RFC3, POLE3, RFC2, RFC5, CDK7, RFC4, ERCC2, XPA, GTF2H4, ERCC3",0.0726296369609765,0,FALSE +"H1299","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.34236,-1.07,0.322,7512,0.512,"MAN1B1, B4GALT3, MAN1A2, ALG12, ALG13, MGAT5, B4GALT1, MGAT4A, ST6GAL1",0.492144128304169,0.290730039024169,FALSE +"H1299","Input","KEGG_OLFACTORY_TRANSDUCTION",0.224,0.724,0.821,1062,1,"PDE1C, CNGB1",0.0856568428805592,0,FALSE +"H1299","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.35284,1.13,0.295,2549,0.971,"MTHFD1L, MTHFD2L, MTHFD2, TYMS, GART, MTHFD1",0.530177984021837,0.0127807700919951,FALSE +"H1299","Input","KEGG_OOCYTE_MEIOSIS",0.3392,1.08,0.317,2416,0.891,"STAG3, ESPL1, CDK1, BUB1, CCNB1, ANAPC4, PPP2R5E, PPP2R5D, PPP2R5C, ANAPC5, CDC20, PPP2R1B, SGO1, CDC16, YWHAZ, CCNB2, CDC27, CHP1, ANAPC1, PLK1, PPP1CC, ANAPC7, PPP1CA, CDC23, MAD2L2, SLK, SMC3, ANAPC2, ITPR1, PPP3CC, YWHAB",0.498940737782249,0.0501222959631252,FALSE +"H1299","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.44465,-1.4,0.0998,7614,0.283,"FUCA2, GLB1, GBA, FUCA1",1.00086945871263,0.54821356447571,FALSE +"H1299","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.22338,0.708,0.834,3800,1,"CYC1, COX15, COX6C, NDUFA9, NDUFB4, UQCRQ, NDUFS2, NDUFB7, NDUFA11, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, COX11, NDUFA4, NDUFC2, NDUFS3, UQCRFS1, ATP6V0A2, NDUFA5, NDUFA2, ATP6V1D, ATP5PO, ATP6V1C1, NDUFA6, NDUFA10, COX4I1, COX6B1, ATP5PB, NDUFB10, NDUFB9, SDHD, COX5A, ATP5MG, UQCRC2, NDUFB2, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB",0.0788339493622613,0,FALSE +"H1299","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.71766,-2.27,0.00183,7307,0.0442,"GALNT14, GALNT15, GALNT13, GALNT7, B3GNT6, GALNT1, GALNT6, B4GALT5, GALNT2, GALNT5, ST3GAL1, GALNT3, GALNT12",2.73754891026957,1.35457773065091,TRUE +"H1299","Input","KEGG_P53_SIGNALING_PATHWAY",0.24681,0.8,0.727,1843,1,"SERPINE1, STEAP3, CDK6, CDK1, CCNB1, CD82, CYCS, CCNB2, CHEK1, RRM2B, RRM2, GTSE1",0.138465589140962,0,FALSE +"H1299","Input","KEGG_PANCREATIC_CANCER",-0.19446,-0.606,0.94,7916,0.993,"CDK4, STAT1, ARHGEF6, PIK3CD, CCND1, ERBB2, TP53, RAC2",0.0268721464003014,0.00305075150461883,FALSE +"H1299","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.41145,-1.28,0.167,6012,0.344,"COASY, PPCS, PANK3, PANK2, BCAT2, ENPP1, PANK1",0.777283528852417,0.46344155742847,FALSE +"H1299","Input","KEGG_PARKINSONS_DISEASE",0.27221,0.879,0.564,4015,1,"UCHL1, CYC1, COX6C, HTRA2, NDUFA9, CYCS, NDUFB4, UQCRQ, NDUFS2, UBE2G1, NDUFB7, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, NDUFA4, NDUFC2, NDUFS3, UQCRFS1, CASP3, NDUFA5, NDUFA2, ATP5PO, NDUFA6, NDUFA10, COX4I1, UBE2J2, COX6B1, ATP5PB, NDUFB10, NDUFB9, SDHD, COX5A, UQCRC2, APAF1, NDUFB2, CASP9, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB, SLC25A31, NDUFV1, ATP5F1A, UQCRH, VDAC2, ATP5F1C",0.248720896016658,0,FALSE +"H1299","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.2403,-0.771,0.749,8587,0.873,"ACTG1, CTNNB1, TUBA4A, CDH1",0.125518182300534,0.0589857562944303,FALSE +"H1299","Input","KEGG_PATHWAYS_IN_CANCER",-0.28055,-0.897,0.569,7701,0.708,"LAMB3, LAMC1, CBLB, FZD7, ARNT, EGLN1, GSK3B, CDK4, STAT1, FOXO1, CREBBP, APC, KITLG, TCF7L1, TRAF5, SHH, EP300, PIK3CD, SKP2, ITGAV, CCND1, LAMA3, LAMA4, NCOA4, LEF1, ERBB2, LAMA1, PTGS2, WNT16, AR, CTNNB1, NFKBIA, LAMA5, SUFU, MITF, GSTP1, CEBPA, IL6, LAMB1, COL4A1, CTNNA1, RXRG, TRAF4, FN1, CTNNA2, RXRA, TP53, RAC2, COL4A2, CDH1, WNT11",0.244887733604929,0.149966742310231,FALSE +"H1299","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.63939,-2.01,0.00717,5961,0.0872,"UGP2, GUSB, RPE, XYLB, UGDH, AKR1B1, CRYL1, DCXR",2.1444808443322,1.05948351506743,TRUE +"H1299","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.49597,-1.57,0.0581,6410,0.191,"PRPS1, PRPS1L1, DERA, PFKL, PFKM, ALDOA, H6PD, PGD, G6PD, TALDO1, TKT, PGM1, ALDOC",1.23582386760967,0.718966632752272,FALSE +"H1299","Input","KEGG_PEROXISOME",-0.44561,-1.37,0.134,7248,0.296,"GSTK1, AGXT, EHHADH, MVK, SCP2, PEX13, HSD17B4, GNPAT, DECR2, AMACR, PHYH, ABCD3, PECR, ACOX1, ACAA1, ACSL1, DHRS4, IDH1, NUDT12, EPHX2, ACSL5, IDH2",0.872895201635192,0.528708288941061,FALSE +"H1299","Input","KEGG_PHENYLALANINE_METABOLISM",-0.60771,-1.93,0.0162,6665,0.101,"ALDH3B1, PRDX6, PAH, MIF, MAOA, DDC, ALDH3A1, MAOB, ALDH1A3",1.79048498545737,0.995678626217357,TRUE +"H1299","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.21024,0.65,0.89,999,1,"DGKE, IMPA1, PLCB4, SYNJ2, SYNJ1, INPP5K, INPP4B",0.0506099933550872,0,FALSE +"H1299","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.32269,-1.02,0.368,7998,0.561,"HMBS, FTH1, UROS, CP",0.434152181326482,0.251037138743839,FALSE +"H1299","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.50039,-1.58,0.0568,7013,0.189,"SLC27A1, RXRB, ACOX2, APOA1, EHHADH, PDPK1, PCK2, SCP2, CPT2, SORBS1, OLR1, HMGCS2, CYP27A1, FABP7, ACOX1, ACAA1, ACSL1, FABP3, ME1, RXRG, APOA2, LPL, RXRA, ACSL5, FABP1, FADS2",1.24565166428898,0.723538195826756,FALSE +"H1299","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.72431,-2.26,0.00538,7780,0.0412,"SCP2, HSD17B4, AMACR, CYP27A1, CYP7B1, HSD3B7",2.26921772433361,1.38510278396687,TRUE +"H1299","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.37526,-1.2,0.236,8065,0.387,"ADA, LCK, BTK",0.627087997029893,0.412289034981089,FALSE +"H1299","Input","KEGG_PRION_DISEASES",-0.39415,-1.26,0.184,5965,0.344,"NOTCH1, SOD1, MAPK3, BAX, HSPA5, C9, NCAM1, LAMC1, PRKACB, C5, IL6",0.735182176990464,0.46344155742847,FALSE +"H1299","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.23397,0.747,0.766,2064,1,"HSP90AA1, CDK1, BUB1, CCNB1, ANAPC4, ANAPC5, AKT1, HSP90AB1, CDC16, CCNB2, CDC27, ANAPC1, PLK1, AKT2, AKT3, ANAPC7, CDC23, MAD2L2",0.115771230367396,0,FALSE +"H1299","Input","KEGG_PROPANOATE_METABOLISM",-0.61286,-1.96,0.00187,7127,0.104,"ACSS2, ALDH9A1, SUCLA2, EHHADH, SUCLG2, SUCLG1, HIBCH, ALDH3A2, LDHA, PCCA, ACSS3, ALDH6A1, ACSS1, PCCB, ALDH2, ABAT, ALDH1B1, MCEE",2.7281583934635,0.98296666070122,TRUE +"H1299","Input","KEGG_PROSTATE_CANCER",-0.30791,-0.948,0.463,6891,0.636,"HSP90B1, SOS1, CREB5, HRAS, CREB1, PDPK1, IGF1R, TCF7L2, GSK3B, FOXO1, CREBBP, TCF7L1, EP300, PIK3CD, CCND1, LEF1, ERBB2, AR, CREB3L2, CTNNB1, NFKBIA, GSTP1, TP53",0.334419008982047,0.196542884351586,FALSE +"H1299","Input","KEGG_PROTEASOME",0.21338,0.678,0.867,4175,1,"SEM1, PSMC1, POMP, PSMB5, PSMC2, PSMD4, PSMD6, PSME4, PSMB4, PSMB7, PSMD1, PSMB6, PSMB2, PSMD13, PSMD8, PSMD11, PSMC5, PSMA8, PSMF1, PSMD12, PSMD3, PSMD14, PSMA4, PSMB1, PSMD7, PSMD2, PSMC6, PSMC4, PSMA1, PSMA2, PSMA3",0.0619809025237897,0,FALSE +"H1299","Input","KEGG_PROTEIN_EXPORT",0.22507,0.723,0.797,2880,1,"SEC63, SRPRA, OXA1L, SRPRB, SRP14, IMMP2L",0.0985416786038876,0,FALSE +"H1299","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.65934,-2.07,0.00365,7168,0.111,"ATP1A3, ATP1A1, SLC25A10, PCK2, ATP1B3, CA2, MDH1, ATP1A4, AQP1, ATP1B1, GLUD2",2.43770713554353,0.954677021213343,TRUE +"H1299","Input","KEGG_PURINE_METABOLISM",0.15772,0.492,0.993,2599,0.995,"NT5E, PRIM1, NME6, POLR1E, PRIM2, POLA1, POLE, ADCY10, POLA2, POLE2, PDE1C, POLR2B, NME1, HPRT1, POLE3, POLR2K, RRM2B, POLR2A, PDE6D, RRM2, NT5C3A, GART, POLR2G, NUDT2, PFAS, PNPT1, DGUOK, NME2, GMPS, NT5C2, PDE6C, GMPR2",0.00305075150461883,0.00217691925427455,FALSE +"H1299","Input","KEGG_PYRIMIDINE_METABOLISM",0.27474,0.871,0.561,1879,1,"NT5E, PRIM1, NME6, POLR1E, DHODH, PRIM2, POLA1, POLE, POLA2, POLE2, POLR2B, NME1, UMPS, UCKL1, TXNRD2, POLE3, DUT, POLR2K, RRM2B, POLR2A, TYMS, RRM2, NT5C3A",0.251037138743839,0,FALSE +"H1299","Input","KEGG_PYRUVATE_METABOLISM",-0.39668,-1.26,0.172,7127,0.344,"ACSS2, DLAT, ALDH9A1, PCK2, MDH1, AKR1B1, ALDH3A2, PC, LDHA, HAGH, ACSS1, ME1, ALDH2, ALDH1B1",0.764471553092451,0.46344155742847,FALSE +"H1299","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.18943,-0.593,0.957,7119,0.985,"PIP4K2B, ITGB3, PIP4K2A, HRAS, WASL, RAC1, ITGA2B, CFL1, VAV2, ITGA1, CYFIP2, ITGB8, FGFR4, GNA13, BRK1, WASF2, ARHGAP35, IQGAP2, ARHGEF6, APC, FGD1, GIT1, PIK3CD, ITGAV, MYL9, ITGB2, ACTG1, BAIAP2, MYLK, ITGA7, MYH14, ITGB4, SCIN, ENAH, FN1, DIAPH2, ITGB6, RAC2",0.0190880622231565,0.00656376950238827,FALSE +"H1299","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.54176,1.73,0.037,2579,0.675,"GABARAPL2, ULK1, ATG7, GABARAPL1, ATG5, PIK3R4, ULK3, ATG12, PRKAA1, ATG4B, PIK3C3, ATG3",1.431798275933,0.170696227168975,FALSE +"H1299","Input","KEGG_RENAL_CELL_CARCINOMA",0.25385,0.826,0.631,1929,1,"TGFB1, PAK4, JUN, RAP1B, ETS1, AKT1, FH, AKT2, FLCN, CRK, AKT3",0.199970640755866,0,FALSE +"H1299","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.41002,1.32,0.146,3212,0.804,"ANPEP, MME, MAS1, THOP1, CTSA, ACE, LNPEP",0.835647144215563,0.0947439512515487,FALSE +"H1299","Input","KEGG_RETINOL_METABOLISM",-0.47988,-1.54,0.0662,8546,0.204,"CYP3A5, PNPLA4, DHRS4, ALDH1A1, ALDH1A2",1.1791420105603,0.690369832574101,FALSE +"H1299","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.45108,-1.4,0.117,7317,0.283,"ACP5, FLAD1, ENPP1, ACP6",0.931814138253838,0.54821356447571,FALSE +"H1299","Input","KEGG_RIBOSOME",0.5487,1.77,0.0288,3176,0.874,"RPL22, RPL26L1, RPL7, RPL8, RPL6, RPS23, RPL14, RPL28, RPL29, RPL19, RPL7A, RPS8, RPL36, RPS11, RPL37A, FAU, RPL26, RPL17, RPL23A, RPL34, RPL15, RPL36A, RPL36AL, RPL35A, RPS3A, RPL18, RPL21, RPL10A, RPL32, RPL13A, RPL4, RPL38, RPS6, RPS18, RPL27A, RPS13, RPL31, RPL23, RPS9, RPS29, RPS5, UBA52, RPS24, RPL30, RPL9, RPL37, RPS4X, RPS12, RPS15, RPS19, RPS25, RPL24, RSL24D1, MRPL13, RPL13, RPS17, RPL18A, RPL5, RPL3, RPL27, RPL35, RPL10, RPS2, RPS15A",1.54060751224077,0.058488567365597,FALSE +"H1299","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.25725,-0.793,0.689,7646,0.856,"ISG15, MAP3K1, SIKE1, MAVS, CYLD, NFKBIA, DDX3Y, MAPK13, CASP10",0.161780778092374,0.0675262353228468,FALSE +"H1299","Input","KEGG_RNA_DEGRADATION",0.22372,0.705,0.821,3281,1,"MTREX, EXOSC10, EXOSC5, EXOSC7, EXOSC9, EXOSC3, XRN1, EXOSC8, EXOSC1, PNPT1, EXOSC6, LSM1, CNOT4, CNOT6L, EXOSC2, LSM2, HSPD1, HSPA9, PAPOLA, PATL1, CNOT2",0.0856568428805592,0,FALSE +"H1299","Input","KEGG_RNA_POLYMERASE",0.19896,0.638,0.915,3472,1,"POLR1E, POLR2B, POLR2K, POLR2A, POLR2G, POLR2E, POLR2I, POLR2J, POLR3G, POLR2C",0.0385789059335517,0,FALSE +"H1299","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.31116,-0.981,0.435,6936,0.61,"PAPSS1, GGT7, SEPHS1, AHCYL1, SCLY, MAT1A, GGT1, CTH",0.361510743045363,0.214670164989233,FALSE +"H1299","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.39391,-1.25,0.179,8251,0.345,"PIK3CD, SKP2, ITGAV, CCND1, LAMA3, LAMA4, LAMA1, PTGS2, NFKBIA, LAMA5, FHIT, LAMB1, COL4A1, RXRG, TRAF4, FN1, RXRA, TP53, COL4A2",0.747146969020107,0.462180904926726,FALSE +"H1299","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.1493,-0.476,1,9227,0.997,"VAMP8",0,0.00130484168834428,FALSE +"H1299","Input","KEGG_SPHINGOLIPID_METABOLISM",0.33909,1.06,0.344,970,0.856,"UGCG, UGT8, SMPD2, SGPP1, GALC, KDSR, PLPP2",0.46344155742847,0.0675262353228468,FALSE +"H1299","Input","KEGG_SPLICEOSOME",0.53244,1.72,0.0484,3386,0.524,"DHX16, ALYREF, DHX38, BUD31, PRPF8, HNRNPA1, SNRPA, CDC5L, DDX23, PRPF6, RBM25, EFTUD2, SNRNP200, PRPF3, SNRPD3, CDC40, USP39, CTNNBL1, HNRNPU, SRSF9, PRPF31, PLRG1, AQR, SNRPE, MAGOHB, WBP11, SF3B4, BCAS2, NCBP1, SNRNP40, TXNL4A, U2AF2, SART1, RBM22, SF3B1, PPIL1, DDX39B, PUF60, HSPA1A, SNW1, DDX5, SNRPB, PRPF38A, RBMX, SYF2, XAB2, PQBP1, EIF4A3, CHERP, U2AF1, SLU7, HSPA8, SRSF6, TCERG1, NCBP2, TRA2B, TRA2A, SNRPB2, PRPF19, SNRPD1, SNRPD2, PRPF40A, SRSF5, HNRNPC, SNRPC, SNU13, SF3A3, SNRPG, SNRPA1, LSM2, SF3B6, HSPA6, SNRPF, SF3A1, PHF5A, SRSF1, PRPF4, CWC15, HNRNPM, SRSF4, U2SURP, DDX46, SF3A2, SMNDC1, CRNKL1",1.31515463835559,0.280668713016273,FALSE +"H1299","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.55258,-1.71,0.0423,5917,0.136,"SI, GBE1, UGP2, AGL, GUSB, HK2, HK3, PYGB, PGM2L1, GANC, PYGL, UGDH, ENPP1, HK1, PGM1, UXS1, GYS1, GAA",1.37365963262496,0.866461091629782,TRUE +"H1299","Input","KEGG_STEROID_BIOSYNTHESIS",-0.62292,-1.95,0.00883,6846,0.103,"LSS, CEL, LIPA, FDFT1, EBP, HSD17B7, DHCR7, SC5D, DHCR24, SQLE, MSMO1",2.05403929642243,0.987162775294828,TRUE +"H1299","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.7242,-2.29,0.00182,7022,0.0455,"HSD17B8, AKR1C3, HSD17B12, AKR1C1, AKR1C2, HSD17B7, CYP1B1, CYP7B1, CYP3A5, HSD17B2, HSD3B1, STS, HSD11B2, CYP21A2",2.73992861201493,1.34198860334289,TRUE +"H1299","Input","KEGG_SULFUR_METABOLISM",-0.57833,-1.82,0.0201,6936,0.116,"PAPSS1, CHST11, BPNT1, CHST13, CHST12, SULT1A1, SULT1A3",1.69680394257951,0.935542010773082,TRUE +"H1299","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.22562,0.722,0.817,2791,1,"ELANE, CD40, SNRPD3, SNRPB, ACTN4, ACTN1, SNRPD1, C2",0.0877779434675845,0,FALSE +"H1299","Input","KEGG_TASTE_TRANSDUCTION",-0.58189,-1.85,0.0207,6807,0.112,"GNAS, GNB1, PRKACB, GNB3, CACNA1A",1.68402965454308,0.950781977329818,TRUE +"H1299","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.47691,-1.5,0.0826,7560,0.23,"MVK, HMGCR, HMGCS2, GGPS1, HMGCS1",1.08301995267962,0.638272163982407,FALSE +"H1299","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.23701,0.78,0.752,1541,1,"TGFB1, SMURF1, SMURF2, THBS3, ZFYVE9, PPP2R1B, ACVR1, MYC",0.123782159408358,0,FALSE +"H1299","Input","KEGG_THYROID_CANCER",-0.59161,-1.9,0.0177,7024,0.102,"RXRB, PAX8, HRAS, CCDC6, TCF7L2, TCF7L1, CCND1, NCOA4, LEF1, CTNNB1, RXRG, RXRA, TP53, CDH1",1.75202673363819,0.991399828238082,TRUE +"H1299","Input","KEGG_TIGHT_JUNCTION",-0.47267,-1.47,0.0991,7888,0.243,"SRC, CDK4, TJP3, AMOTL1, MAP3K20, EXOC4, PPP2R2A, PATJ, MYL9, PRKCH, PARD6G, F11R, ACTG1, PPP2R2B, PARD6B, TJP2, MYH14, MYH7B, PRKCD, CTNNB1, SPTAN1, EPB41, LLGL2, EPB41L3, CLDN3, CTNNA1, CLDN4, CTNNA2, CLDN6, PRKCQ, EPB41L1, CLDN7, CRB3",1.00392634551472,0.614393726401688,FALSE +"H1299","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.24179,-0.776,0.755,8511,0.881,"TOLLIP, NFKBIA, IL6, MAPK13, MAP2K6, MYD88",0.122053048370812,0.0550240915879521,FALSE +"H1299","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.528,-1.66,0.0461,7164,0.156,"ALDH9A1, KYNU, EHHADH, MAOA, ALDH3A2, GCDH, CYP1B1, DDC, ALDH2, MAOB, ALDH1B1",1.33629907461035,0.806875401645538,TRUE +"H1299","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.43264,-1.36,0.127,5981,0.301,"IKBKB, PIK3R2, HK2, PIK3R3, HK3, MAPK3, PDX1, MAPK8, ABCC8, HK1, PIK3CD, INSR, IRS2, PRKCD, CACNA1A",0.896196279044043,0.521433504406157,FALSE +"H1299","Input","KEGG_TYROSINE_METABOLISM",-0.46463,-1.45,0.114,8463,0.255,"DDC, DCT, HGD, ALDH3A1, TYRP1, MAOB, ALDH1A3, GSTZ1",0.943095148663527,0.593459819566045,FALSE +"H1299","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.1836,-0.595,0.969,7371,0.992,"NCK2, PDPK1, VAV2, CBLB, GSK3B, CDK4, DLG1, PIK3CD, LCK, PTPN6, NFKBIA, MAPK13, PRKCQ",0.0136762229492347,0.00348832784582135,FALSE +"H1299","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29335,0.949,0.474,1847,1,"FBXO2, UBE2W, SMURF1, FBXW7, TRIP12, UBE4B, CDC34, NEDD4, CUL7, ANAPC4, BIRC2, SMURF2, CBL, HERC4, ANAPC5, UBE2B, BIRC6, UBE2K, CDC20, FANCL, CDC16, UBE2G1, CDC27, TRAF6, FBXO4, ANAPC1, CUL3, HERC2",0.324221658325915,0,FALSE +"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.3668,1.16,0.245,3335,0.949,"BCAT1, VARS2, PDHA1",0.610833915635468,0.0227337875727074,FALSE +"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.54959,-1.75,0.0193,7850,0.142,"DBT, HIBCH, ALDH3A2, AUH, PCCA, HMGCS2, ALDH6A1, ACAA1, HMGCS1, ACADS, PCCB, ALDH2, ABAT, ALDH1B1, HIBADH, MCEE",1.71444269099223,0.847711655616944,TRUE +"H1299","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.3999,-1.26,0.165,7247,0.344,"ADCY9, GUCY1A1, MYH11, GNA11, MYL6B, GNAQ, GNA13, MYL6, ARHGEF11, PRKACB, MYL9, PLA2G12A, PRKCH, MYLK, PRKCD, ADCY5, PLCB1, PLA2G4A, PRKCQ",0.782516055786094,0.46344155742847,FALSE +"H1299","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.23715,-0.737,0.77,6807,0.917,"GNAS, AVP, DCTN6, CREB5, ADCY9, CREB1, RAB5C, PRKACB, DYNLL2, ARHGDIB, CREB3L2",0.113509274827518,0.0376306643299789,FALSE +"H1299","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.247,-0.775,0.754,8251,0.874,"PIK3CD, PLA2G12A, PTGS2, PLA2G4A, MAPK13, RAC2",0.122628654130226,0.058488567365597,FALSE +"H1299","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.44029,-1.37,0.135,6334,0.296,"ATP6V0A1, ATP6V1G1, ATP6V0C, ATP6AP1, PLCG2, ATP6V1E1, GNAS, TJP1, ATP6V1F, ADCY9, ATP6V1C2, KDELR3, SLC12A2, PRKACB, ATP6V0D1, ATP6V0D2, PDIA4, ACTG1, TJP2, KDELR1",0.869666231504994,0.528708288941061,FALSE +"H1299","Input","KEGG_VIRAL_MYOCARDITIS",-0.37315,-1.17,0.234,8387,0.398,"ITGB2, CCND1, ACTG1, CD55, MYH14, MYH7B, SGCD, RAC2",0.630784142589857,0.400116927926312,FALSE +"H1299","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.29815,-0.942,0.457,7299,0.64,"RAC1, CTBP2, CSNK1E, TBL1XR1, TCF7L2, SFRP1, FZD7, PRKACB, DKK1, GSK3B, CREBBP, APC, TCF7L1, TBL1X, EP300, PPP2R5A, CCND1, LEF1, DAAM2, NKD2, WNT16, CTNNB1, PLCB1, DAAM1, TP53, RAC2, WNT11",0.34008379993015,0.193820026016113,FALSE +"H1703","Input","KEGG_ABC_TRANSPORTERS",-0.4043,-1.19,0.24,7682,0.564,"ABCD4, ABCD3, ABCC3, ABCG2, ABCA2, ABCB6, ABCA1",0.619788758288394,0.248720896016658,FALSE +"H1703","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.27251,-0.806,0.691,6970,0.934,"PML, MYC, PIK3CA, TCF7L2, PIM1, PIK3CB, HRAS, PIK3R1, PIK3R2, PIK3CD, CCND1, RUNX1",0.160521952625802,0.0296531237699066,FALSE +"H1703","Input","KEGG_ADHERENS_JUNCTION",-0.28153,-0.852,0.631,7033,0.904,"PTPN6, RAC3, MET, TCF7L2, BAIAP2, CTNNA2, TGFBR1, CTNNA1, PTPRF, PTPN1, SNAI2, CTNNB1, ACTN4, CTNND1, IGF1R, RAC2, WAS",0.199970640755866,0.0438315695246367,FALSE +"H1703","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.23757,0.735,0.817,2487,0.985,"STAT3, ACACB, NFKBIE, MAPK9, TNFRSF1A, MAPK10, IKBKG, CPT1A, NFKBIB, CPT1C, RELA, PRKAB2, MAPK8, CAMKK2, TRAF2, AKT1, TRADD, STK11, PRKAB1, NFKB1, PRKAG2",0.0877779434675845,0.00656376950238827,FALSE +"H1703","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.36686,1.12,0.277,1463,0.883,"GLUL, ASNS, GLUD2, NIT2, ADSL, ASL, CAD, GOT1",0.557520230935551,0.0540392964224314,FALSE +"H1703","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.50319,-1.45,0.0997,6972,0.446,"HSD11B2, PIK3CA, IRS2, PIK3CB, PDPK1, SFN, ATP1A2, PIK3R1, IRS1, PIK3R2, SLC9A3R2, PIK3CD",1.00130484168834,0.350665141287858,FALSE +"H1703","Input","KEGG_ALZHEIMERS_DISEASE",0.28813,0.897,0.554,3141,0.979,"GRIN1, ATP2A3, GAPDH, COX6A1, PSEN2, COX6C, TNFRSF1A, PLCB2, NDUFA4, CASP7, CAPN1, COX7C, ITPR2, PLCB3, NDUFA8, COX7A2, CASP9, SDHA, MAPT, SDHB, BID, ATP5F1B, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, IDE, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, ATP5PD, UQCRQ, UQCRC1, CASP3, NDUFA7, CDK5, UQCRH, CALML3, NDUFC1, BAD, NDUFB5, NDUFS5, CYCS, NDUFA2, SDHD, CALM2, BACE2, NDUFB1, GNAQ, NDUFC2, CASP8, COX5A, NDUFB10, NDUFS7, PSEN1, UQCRC2, ATP5PB, NDUFS8, NDUFV3",0.25649023527157,0.00921730819686218,FALSE +"H1703","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.22961,-0.683,0.885,7187,0.983,"NARS2, EARS2, PARS2, CARS2, MARS2",0.0530567293021746,0.00744648216786438,FALSE +"H1703","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.23201,0.711,0.781,2568,0.979,"AMDHD2, UAP1, NANS, PGM1, FPGT, PMM1, GALK1, GNPDA2, HEXB, GNPDA1, GPI, CMAS, GNE, PGM3",0.1073489661227,0.00921730819686218,FALSE +"H1703","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.24648,-0.737,0.816,9109,0.938,"GPX1, CASP1, TOMM40L",0.0883098412461389,0.0277971616209356,FALSE +"H1703","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.4093,1.26,0.193,1493,0.742,"TAPBP, TAP1, CTSL, HSPA4, RFXAP, B2M, TAP2, RFXANK, IFI30, RFX5, HSP90AB1",0.714442690992226,0.129596094720973,FALSE +"H1703","Input","KEGG_APOPTOSIS",0.23804,0.716,0.83,1398,1,"DFFA, RIPK1, PRKAR2B, TNFRSF1A, IL1A, ATM, XIAP, AIFM1, CASP7, IKBKG, CAPN1, MYD88, DFFB, CASP9, RELA, BID",0.0809219076239261,0,FALSE +"H1703","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.68528,-2.05,0.00671,8675,0.105,"GGT5, PTGES, EPHX2, GPX6, GPX7, GPX1, PTGS2",2.17327747983101,0.978810700930062,TRUE +"H1703","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.40013,-1.18,0.216,7871,0.535,"ALDH18A1, CKMT1A, SAT1, P4HA1, CKMT2, GLS, GLS2, P4HA2, ASS1, PRODH, PRODH2, CPS1, MAOA, AGMAT, ARG2, ARG1, LAP3",0.665546248849069,0.271646217978772,FALSE +"H1703","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.61267,-1.82,0.0214,7584,0.23,"CTNNA2, ITGA11, DSG2, ITGA6, CTNNA1, ATP2A2, ITGA1, ITGA4, DSC2, ITGB6, ITGB4, ITGA7, CTNNB1, ACTN4, ITGB3, SLC8A1, GJA1, ITGA2, ITGB8",1.66958622665081,0.638272163982407,TRUE +"H1703","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.52978,1.63,0.0682,110,0.539,"ALDH3A2",1.16621562534352,0.268411234813261,FALSE +"H1703","Input","KEGG_AXON_GUIDANCE",-0.3431,-1.03,0.397,6981,0.666,"RGS3, PTK2, RAC3, GNAI3, PPP3R1, EPHA6, MET, PAK4, ARHGEF12, PPP3CA, EFNA1, PPP3CC, DPYSL5, GNAI1, HRAS, EPHA1, NRP1, EPHA4, SEMA4G, NTN4, PLXNA2, EPHA7, EFNB2, ABLIM1, ABLIM3, EPHB2, SEMA7A, RAC2, NFATC4, CXCR4",0.401209493236885,0.176525770829699,FALSE +"H1703","Input","KEGG_BASAL_CELL_CARCINOMA",0.32135,0.989,0.401,870,0.898,"GLI3, DVL2, FZD2",0.396855627379818,0.0467236633326956,FALSE +"H1703","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.19091,-0.57,0.989,6148,1,"TAF4, TAF5L, GTF2E1, TAF5, GTF2A1, TAF1, GTF2H4, GTF2I, GTF2H2, GTF2H3, GTF2H1",0.0048037084028206,0,FALSE +"H1703","Input","KEGG_BASE_EXCISION_REPAIR",0.26895,0.823,0.668,2966,0.961,"MUTYH, PARP4, POLD4, HMGB1, NEIL2, PCNA, APEX1, POLL, POLE, POLD2, NTHL1",0.175223537524454,0.0172766123314547,FALSE +"H1703","Input","KEGG_BETA_ALANINE_METABOLISM",0.33325,0.994,0.414,993,0.944,"ALDH3A2, SMS",0.382999658879101,0.025028005701931,FALSE +"H1703","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.30453,-0.895,0.574,7063,0.83,"ACOT2, ACOX3, ACOX1, TECR, HSD17B12, FADS2, ELOVL6",0.241088107602027,0.0809219076239261,FALSE +"H1703","Input","KEGG_BLADDER_CANCER",-0.47013,-1.37,0.139,7425,0.524,"DAPK1, CDK4, VEGFC, HRAS, TYMP, THBS1, VEGFA, MMP2, CCND1, CDKN1A",0.856985199745905,0.280668713016273,FALSE +"H1703","Input","KEGG_BUTANOATE_METABOLISM",-0.43968,-1.32,0.146,7866,0.519,"HMGCS1, BDH2, ABAT, ACSM3, BDH1, HMGCS2, ACADS",0.835647144215563,0.284832642151542,FALSE +"H1703","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.35552,-1.05,0.371,7033,0.657,"PTPN6, RAC3, PPP3R1, PIK3CA, LYN, PPP3CA, PPP3CC, PIK3CB, VAV3, HRAS, PIK3R1, SYK, PIK3R2, PIK3AP1, CD81, PIK3CD, INPP5D, RAC2, NFATC4",0.430626090384954,0.182434630440219,FALSE +"H1703","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2345,0.715,0.838,1722,0.989,"PDGFRA, GRIN1, ATP2A3, RYR1, PLCB2, ITPR2, PLCB3, PLCG2, PLCD1, TACR1, NOS3, PHKA1, PHKB, PRKACA, PRKCA, PPID",0.0767559813697235,0.0048037084028206,FALSE +"H1703","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.3647,1.11,0.306,2335,0.833,"CACNA2D1, TPM2, COX6A1, COX6C, COX7C, TPM3, COX7A2, TPM1, UQCRB, COX5B, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, UQCRQ, UQCRC1, UQCRH",0.51427857351842,0.0793549985932124,FALSE +"H1703","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.4641,-1.41,0.1,7987,0.492,"PTPRC, PTPRF, CNTN1, ITGA4, NRCAM, ICAM1, CLDN7, ICAM2, SDC1, PDCD1LG2, CLDN3, SDC2, CADM1, SDC4, NCAM1, VCAN, CD274, PECAM1, F11R, ITGB8",1,0.30803489723264,FALSE +"H1703","Input","KEGG_CELL_CYCLE",-0.14348,-0.426,0.998,7005,1,"TP53, BUB1B, ORC6, MYC, CCND3, CDK7, CCNB2, SKP2, CDK4, TGFB3, CDC7, SFN, BUB1, RBL1, WEE1, CDC6, TGFB2, CCND1, CDKN1A",0.000869458712628891,0,FALSE +"H1703","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.3855,-1.12,0.3,7014,0.612,"CCL13, RAP1B, PTK2, GNAI3, CCL20, PLCB4, PIK3CA, GNG5, CXCL6, JAK3, ARRB1, GNB1, LYN, PRKCD, RAP1A, GNB3, PIK3CB, GNAI1, STAT2, VAV3, HRAS, ADCY9, PIK3R1, GNG2, PIK3R2, PTK2B, PIK3CD, RAC2, CXCR4, WAS, CXCL1",0.522878745280338,0.213248577854439,FALSE +"H1703","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.35831,-1.08,0.317,7539,0.631,"CDK4, PIK3CB, TGFB3, TGFBR1, BCL2L1, HRAS, PIK3R1, CBLB, PIK3R2, PIK3CD, MECOM, TGFB2, GAB2, CCND1, RUNX1, CDKN1A",0.498940737782249,0.199970640755866,FALSE +"H1703","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.35652,-1.06,0.361,6420,0.66,"CSNK1D, CLOCK, BHLHE41, BHLHE40, CSNK1E",0.442492798094342,0.180456064458131,FALSE +"H1703","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.13956,-0.413,1,1286,1,"ACO2, SDHA, SDHB, MDH1, ACLY, DLD, SDHD, FH, PCK2, PDHB, IDH3A, PDHA1, ACO1, SDHC, IDH3G, SUCLG2, SUCLG1, OGDH, OGDHL, MDH2, IDH1, DLAT, SUCLA2, IDH3B, IDH2, DLST, CS, PC, PCK1",0,0,FALSE +"H1703","Input","KEGG_COLORECTAL_CANCER",-0.25572,-0.763,0.763,7005,0.922,"TP53, RAC3, MYC, PIK3CA, TCF7L2, PIK3CB, TGFB3, TGFBR1, APC, PIK3R1, CTNNB1, PIK3R2, PIK3CD, TGFB2, RAC2, CCND1",0.11747546204512,0.0352690789463706,FALSE +"H1703","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.37835,-1.1,0.317,7762,0.626,"PROC, PLAT, C9, F5, PLAUR, C3, THBD, PLAU, SERPINA1, CD59, SERPINC1, CD55, MBL2",0.498940737782249,0.20342566678957,FALSE +"H1703","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.27725,0.867,0.588,1617,0.963,"LDHB, MTAP, CDO1, SMS, MPST, GOT1, MAT2B, AHCY",0.230622673923862,0.0163737128754655,FALSE +"H1703","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.32933,-0.965,0.464,8580,0.714,"EPO, IL6, VEGFA, IL1RAP, ACVR1B, TGFB2, TNFRSF12A, IL1R1, CXCR4, CXCL1, LTBR",0.333482019445119,0.146301788223826,FALSE +"H1703","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.33329,-0.979,0.426,7330,0.707,"ADAR, POLR3D, POLR3H, POLR3A, POLR3K, POLR3B, IL6, PYCARD, TREX1, CASP1",0.370590400897281,0.150580586203101,FALSE +"H1703","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.53769,-1.57,0.0637,7673,0.356,"TGFB3, ITGA11, TTN, GNAS, ITGA6, ATP2A2, ITGA1, ITGA4, ADCY9, ITGB6, ITGB4, ITGA7, TNNC1, ITGB3, SLC8A1, TGFB2, ITGA2, ITGB8",1.19586056766465,0.448550002027125,FALSE +"H1703","Input","KEGG_DNA_REPLICATION",0.36361,1.14,0.29,4066,0.914,"RNASEH2C, RPA3, POLD4, MCM5, RFC4, POLA2, POLA1, MCM3, PCNA, POLE, POLD2, PRIM2, MCM7, MCM4, RFC2, MCM6, RFC5, RNASEH2B, RNASEH2A, PRIM1, LIG1, POLD3, MCM2, RPA2",0.537602002101044,0.0390538042661686,FALSE +"H1703","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.55424,1.75,0.0326,2068,0.614,"ETS1, NOTCH3, SPIRE1, SPIRE2, EGFR, NOTCH2",1.48678239993206,0.211831628858832,FALSE +"H1703","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.50548,-1.52,0.066,8388,0.382,"ALDH3A1, GSTM4, GSTM1, MAOA, GSTT2, GSTM2, MGST1",1.18045606445813,0.417936637088291,FALSE +"H1703","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.2743,-0.82,0.667,8059,0.928,"NAT2, TYMP, CES1, CES2, CDA",0.175874166083451,0.0324520237811379,FALSE +"H1703","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.7124,-2.11,0.00676,8151,0.119,"HSPG2, ITGA1, ITGA4, COL6A3, COL1A2, ITGB6, ITGB4, VTN, COL11A1, LAMB3, ITGA7, LAMC2, LAMA3, LAMA4, SDC1, FN1, THBS1, COL5A1, CD36, TNC, SDC2, COL6A1, LAMB1, ITGB3, COL3A1, SDC4, AGRN, ITGA2, CD44, ITGB8",2.17005330405836,0.924453038607469,TRUE +"H1703","Input","KEGG_ENDOCYTOSIS",0.16136,0.491,1,676,1,"PDGFRA, PLD2, DNM1L, IQSEC1, EPN2, RAB11FIP3, VPS4B, RUFY1, RABEP1, STAM2",0,0,FALSE +"H1703","Input","KEGG_ENDOMETRIAL_CANCER",-0.40798,-1.23,0.198,7005,0.573,"TP53, MYC, PIK3CA, TCF7L2, CTNNA2, PIK3CB, PDPK1, ILK, APC, CTNNA1, HRAS, PIK3R1, CTNNB1, PIK3R2, PIK3CD, CCND1",0.703334809738469,0.24184537803261,FALSE +"H1703","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.26972,-0.788,0.721,6469,0.926,"TJP1, JUN, ATP6V1A, ATP6V1C2, ATP6V0A2, ATP6V0C, ATP6V1B2, ATP6V0D1, ATP6V1G2, MET, TCIRG1, ATP6V1D, ATP6V1B1, LYN, ATP6V1H, JAM2, ADAM10, MAPK13, F11R, CXCL1",0.142064735280571,0.0333890133180656,FALSE +"H1703","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.18882,-0.559,0.988,7051,0.997,"PTK2, MYC, PIK3CA, PAK4, TGFA, CAMK2D, PIK3CB, MAP2K7, HRAS, PIK3R1, CBLB, PIK3R2, PIK3CD, ERBB3, CDKN1A",0.00524305541237188,0.00130484168834428,FALSE +"H1703","Input","KEGG_ETHER_LIPID_METABOLISM",-0.26861,-0.794,0.74,7594,0.925,"PAFAH2, PLA2G4A, LPCAT2, PLPP3, CHPT1",0.130768280269024,0.0338582672609674,FALSE +"H1703","Input","KEGG_FATTY_ACID_METABOLISM",0.28387,0.864,0.588,1424,0.949,"ALDH3A2, ACAA2, ECI1, ACAT1, CPT1A, ADH5, CPT1C, ECI2",0.230622673923862,0.0227337875727074,FALSE +"H1703","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.44762,-1.33,0.158,7041,0.518,"PLA2G12A, RAC3, PIK3CA, LYN, PRKCD, PIK3CB, MAP2K7, PDPK1, PLA2G4A, VAV3, HRAS, PIK3R1, MAPK13, LCP2, SYK, PIK3R2, PIK3CD, INPP5D, RAC2, GAB2",0.801342913045577,0.285670240254767,FALSE +"H1703","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.39254,-1.18,0.214,7878,0.535,"PLA2G4A, AMPH, VAV3, PTPRC, PIP5K1C, PIK3R1, PLA2G4F, MYO10, ASAP2, SYK, ARPC1A, MARCKS, PLPP3, PIK3R2, SCIN, PIK3CD, INPP5D, RAC2, GAB2, WAS",0.669586226650809,0.271646217978772,FALSE +"H1703","Input","KEGG_FOCAL_ADHESION",-0.39802,-1.22,0.211,8188,0.549,"PIP5K1C, ITGA1, ITGA4, PIK3R1, COL6A3, PDGFRB, COL1A2, ITGB6, ITGB4, VTN, COL11A1, LAMB3, FLNC, ITGA7, LAMC2, CTNNB1, PIK3R2, LAMA3, LAMA4, PARVA, ACTN4, FN1, THBS1, COL5A1, VEGFA, TNC, COL6A1, LAMB1, ITGB3, PIK3CD, COL3A1, IGF1R, RAC2, ITGA2, CCND1, FLNB, ITGB8",0.675717544702307,0.260427655549908,FALSE +"H1703","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.62193,-1.84,0.0231,8632,0.232,"QDPR, PTS",1.63638802010786,0.6345120151091,TRUE +"H1703","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.2272,0.699,0.881,1679,0.966,"TPI1, PHPT1, AKR1B1, FPGT, PMM1, MTMR6, PFKFB3",0.0550240915879521,0.0150228735845067,FALSE +"H1703","Input","KEGG_GALACTOSE_METABOLISM",-0.22831,-0.671,0.886,6436,0.969,"GALE, GAA, PGM2, HK3, PFKM, MGAM, B4GALT1",0.0525662781129492,0.0136762229492347,FALSE +"H1703","Input","KEGG_GAP_JUNCTION",0.366,1.11,0.284,1351,0.833,"PDGFRA, MAPK7, TUBB2B, PDGFC, TUBA3C, TUBB6, PLCB2, TUBA1C, TUBB1, TUBB3, ITPR2, PLCB3, TUBB, TUBB2A, RAF1",0.546681659952962,0.0793549985932124,FALSE +"H1703","Input","KEGG_GLIOMA",-0.25689,-0.763,0.763,8076,0.922,"HRAS, PIK3R1, PDGFRB, PIK3R2, PIK3CD, IGF1R, CCND1, CDKN1A",0.11747546204512,0.0352690789463706,FALSE +"H1703","Input","KEGG_GLUTATHIONE_METABOLISM",-0.54723,-1.6,0.0688,8605,0.354,"GSTM4, GGT5, GSTM1, ANPEP, GPX6, GPX7, GPX1, GSTT2, GSTM2, LAP3, MGST1",1.16241156176449,0.450996737974212,FALSE +"H1703","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.51616,-1.51,0.0771,8591,0.377,"PLPP3, DGAT1, LPL, DGKA, DGKB, LIPG, MGLL",1.11294562194904,0.423658649794207,FALSE +"H1703","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.21067,-0.627,0.944,7873,0.99,"GPD1, PLA2G4A, GPD2, LPCAT2, PLPP3, DGKA, CHPT1, DGKB",0.025028005701931,0.00436480540245009,FALSE +"H1703","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.3134,0.98,0.421,1040,0.867,"SRR, PSAT1, GAMT, MAOB, PIPOX, PHGDH",0.375717904164332,0.0619809025237897,FALSE +"H1703","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.26521,0.822,0.656,1399,0.943,"ALDH3A2, LDHB, TPI1, GAPDH, ENO1, ENO3, PGAM1, PGAM4, ADH5, PGK1, PGM1",0.18309616062434,0.0254883072626717,FALSE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.39567,-1.18,0.224,6744,0.535,"XYLT2, CHST12, B4GALT7, CHPF2, B3GAT3, CHSY1, CHST11, CHPF, CHST14",0.649751981665837,0.271646217978772,FALSE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.70026,-2.07,0.00828,6744,0.108,"XYLT2, B4GALT7, HS2ST1, B3GAT3, GLCE, EXT1, EXTL2, EXTL3, EXT2",2.08196966321512,0.96657624451305,TRUE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.73339,-2.14,0.00165,7501,0.123,"B3GNT2, B4GAT1, B4GALT3, B4GALT4, ST3GAL2, FUT8, B4GALT1",2.78251605578609,0.910094888560602,TRUE +"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.26112,0.803,0.693,3244,0.949,"HYAL2, HEXB, IDUA, GNS, ARSB, HEXA, HYAL1, GALNS",0.159266765388193,0.0227337875727074,FALSE +"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.47906,1.45,0.111,124,0.753,"B4GALNT1",0.954677021213343,0.123205023799299,FALSE +"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.4598,-1.35,0.136,8348,0.537,"ST3GAL2, B3GALNT1",0.866461091629782,0.270025714300444,FALSE +"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.78145,-2.31,0.00166,7501,0.168,"B3GNT2, B4GAT1, B3GNT3, ST3GAL4, B4GALT3, B4GALT4, B4GALT1",2.77989191195995,0.774690718274137,TRUE +"H1703","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.22373,-0.675,0.882,5264,0.974,"PIGS, PIGM, GPAA1, PIGT, PIGK, PIGO, PGAP1",0.0545314148681803,0.0114410431213845,FALSE +"H1703","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.25732,0.791,0.724,1897,0.94,"PGP, MTHFD1L, ACO2, MDH1",0.140261433802853,0.0268721464003014,FALSE +"H1703","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.21049,0.659,0.9,1668,0.991,"MAPK7, PLD2, ATF4, MAPK9, MAP2K4, PLCB2, MAPK10, ITPR2, PLCB3, RAF1, MAPK8, PRKACA, PRKCA",0.0457574905606751,0.00392634551472468,FALSE +"H1703","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.30363,0.915,0.515,1869,0.96,"GLI3, BTRC, PRKACA, FBXW11",0.288192770958809,0.0177287669604316,FALSE +"H1703","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.72282,-2.14,0.00345,7834,0.123,"ITGA6, MME, CD38, ITGA1, ITGA4, EPO, IL6, CD59, CD55, CD36, ITGB3, ANPEP, ITGA2, IL1R1, CD44",2.46218090492673,0.910094888560602,TRUE +"H1703","Input","KEGG_HISTIDINE_METABOLISM",-0.40597,-1.21,0.204,7974,0.554,"ALDH1A3, ALDH3A1, MAOA, HNMT",0.690369832574101,0.25649023527157,FALSE +"H1703","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.42897,1.29,0.157,3182,0.716,"SEM1, BLM, RPA3, POLD4, MRE11, RAD50, EME1, POLD2, NBN, RAD54L, XRCC3",0.804100347590766,0.145086977692144,FALSE +"H1703","Input","KEGG_HUNTINGTONS_DISEASE",0.37406,1.14,0.28,3261,0.914,"GRIN1, COX6A1, DNAH3, SOD1, COX6C, PLCB2, HIP1, NDUFA4, COX7C, PLCB3, TBPL1, DCTN4, NDUFA8, COX7A2, CASP9, SDHA, SDHB, CLTA, ATP5F1B, DCTN2, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, PPID, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, TBP, CLTB, CREB3L1, ATP5PD, IFT57, CLTC, UQCRQ, REST, UQCRC1, DCTN1, CASP3, NDUFA7, TFAM, UQCRH, BAX, NDUFC1, DNAL1, NDUFB5, POLR2H, NDUFS5, HAP1, CYCS, NDUFA2, SDHD, VDAC1, SP1, DNAL4, NDUFB1, GNAQ, NDUFC2, CASP8, COX5A, NDUFB10, NDUFS7, UQCRC2, ATP5PB, NDUFS8, NDUFV3, ATP5F1D, HTT, COX7B",0.552841968657781,0.0390538042661686,FALSE +"H1703","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.5246,-1.56,0.0849,7673,0.35,"TGFB3, ITGA11, TTN, ITGA6, ATP2A2, ITGA1, ITGA4, ITGB6, ITGB4, ACE, ITGA7, IL6, TNNC1, ITGB3, SLC8A1, TGFB2, ITGA2, ITGB8",1.07109230975605,0.455931955649724,FALSE +"H1703","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.28927,0.879,0.597,1591,1,"ISYNA1, TPI1, IMPA1, OCRL, INPP4B, PLCB2, PLCB3, PLCG2, PLCD1, INPP5K, PIK3C3, PTEN",0.224025668870631,0,FALSE +"H1703","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.25191,0.768,0.753,1865,0.952,"EIF4EBP1, CRK, ACACB, SHC1, ACACA, FLOT2, TRIP10, RPS6KB1, FLOT1, PYGL, MKNK1, MAPK9, PRKAR2B, MAPK10, RAF1, PHKA1, INPP5K, CRKL, PHKB, PRKAB2, MAPK8, FOXO1, PRKACA, SREBF1, SORBS1, INSR, RPTOR",0.123205023799299,0.0213630516155257,FALSE +"H1703","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.58073,-1.72,0.0333,8276,0.292,"ITGA4, IL6, CXCR4, LTBR",1.47755576649368,0.534617148551582,FALSE +"H1703","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.42412,-1.24,0.188,7033,0.585,"PTPN6, MYC, PIK3CA, JAK3, CCND3, STAT6, JAK1, PIM1, LEPR, PIK3CB, IL13RA2, STAT2, SPRY1, BCL2L1, PIK3R1, CBLB, EPO, IL6, PIK3R2, PIK3CD, CCND1, SPRY2",0.72584215073632,0.23284413391782,FALSE +"H1703","Input","KEGG_LEISHMANIA_INFECTION",-0.40624,-1.19,0.236,8254,0.564,"C3, ITGA4, TRAF6, MAPK13, CYBA, TGFB2, PTGS2",0.627087997029893,0.248720896016658,FALSE +"H1703","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.43134,-1.26,0.195,7584,0.598,"CTNNA2, PIK3CB, JAM2, GNAI1, VAV3, CTNNA1, ITGA4, PIK3R1, ICAM1, MAPK13, CLDN7, CTNNB1, PIK3R2, ACTN4, CLDN3, PTK2B, CYBA, PIK3CD, CTNND1, RAC2, PECAM1, MMP2, F11R, CXCR4",0.709965388637482,0.223298816011589,FALSE +"H1703","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.56034,1.73,0.0447,110,0.529,"ALDH3A2",1.34969247686806,0.276544327964814,FALSE +"H1703","Input","KEGG_LONG_TERM_DEPRESSION",-0.34395,-1.02,0.381,7041,0.654,"PLA2G12A, GNAI3, PLCB4, PPP2CB, GNA12, GUCY1A1, LYN, GNA11, GNAI1, GNAS, PLA2G4A, ITPR3, HRAS, PRKG1, IGF1R",0.419075024324381,0.184422251675733,FALSE +"H1703","Input","KEGG_LONG_TERM_POTENTIATION",0.27941,0.873,0.613,2911,0.995,"GRIN1, ATF4, RPS6KA1, PLCB2, ITPR2, PLCB3, RAF1, PRKACA, PRKCA, RPS6KA2, CAMK2G, CALML3, MAP2K2, PRKCB, CALM2, RPS6KA3, GNAQ",0.212539525481585,0.00217691925427455,FALSE +"H1703","Input","KEGG_LYSINE_DEGRADATION",-0.27807,-0.819,0.659,7276,0.918,"SUV39H1, DLST, NSD2, SUV39H2, DOT1L, SETD7, PLOD1, PLOD2, AASS",0.18111458540599,0.0371573187987575,FALSE +"H1703","Input","KEGG_LYSOSOME",0.28238,0.852,0.614,1885,0.935,"MCOLN1, NAGA, SUMF1, GGA2, CTSK, CTSO, IGF2R, CTSL, LAMP3, SLC17A5, PSAPL1, CTSG, CLN5, ARSA, GLA, LAMP2, AP1S1, AP1S2, AP3M1, CLTA, AP3S1, AGA, NPC2, PSAP, GGA3, DNASE2, M6PR, AP1M1, AP3B1, AP3D1, HEXB",0.211831628858832,0.0291883891274822,FALSE +"H1703","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.26549,0.812,0.682,2486,0.948,"PDGFRA, MEF2C, TGFBR2, HSPB1, MAPK7, CACNA2D1, MAP3K20, CRK, RELB, NFKB2, ATF4, MKNK1, MAPK9, RPS6KA1, TNFRSF1A, IL1A, MAP2K4, MAPK10, TGFB1, STMN1, IKBKG, NF1, PPM1B, RAF1, RELA, MAPT, MAP3K7, CRKL, MAPK8, ARRB2, TAB2, PRKACA, PRKCA, RPS6KA2, TAB1, EGFR, PAK1, TRAF2, HSPA1A, TAOK1, AKT1, PAK2, MOS, MAPK12, FLNA, HSPA6, CASP3, MAP2K2, HSPA2, RRAS, RASA1, NFKB1, DUSP3",0.166215625343521,0.0231916626619338,FALSE +"H1703","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.47615,-1.39,0.136,7844,0.508,"HNF1B, PDX1, HNF1A, HNF4A",0.866461091629782,0.294136287716081,FALSE +"H1703","Input","KEGG_MELANOGENESIS",-0.21183,-0.625,0.95,6828,0.982,"CREBBP, GNAO1, DVL3, DVL1, GNAI3, PLCB4, WNT5A, TCF7L2, CAMK2D, GNAI1, GNAS, HRAS, MITF, ADCY9, CTNNB1",0.0222763947111523,0.00788851221305034,FALSE +"H1703","Input","KEGG_MELANOMA",-0.30701,-0.922,0.509,8076,0.783,"HRAS, MITF, PIK3R1, PDGFRB, PIK3R2, PIK3CD, IGF1R, CCND1, CDKN1A",0.293282217663241,0.106238237942057,FALSE +"H1703","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.54709,-1.59,0.0528,7974,0.347,"ALDH1A3, AKR1C1, ALDH3A1, GSTM4, CYP2S1, GSTM1, GSTT2, GSTM2, MGST1",1.27736607746619,0.459670525209126,FALSE +"H1703","Input","KEGG_MISMATCH_REPAIR",0.5492,1.71,0.0376,1950,0.475,"PMS2, MSH6, MLH1, MSH2, MSH3, RPA3, POLD4, RFC4",1.42481215507234,0.323306390375133,FALSE +"H1703","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.23104,-0.677,0.9,7171,0.981,"PIK3CA, CAB39, RPS6, PIK3CB, PDPK1, VEGFC, PIK3R1, PIK3R2, VEGFA, PIK3CD",0.0457574905606751,0.0083309926200515,FALSE +"H1703","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.37381,-1.11,0.295,7033,0.618,"PTPN6, RAC3, PPP3R1, ITGB2, PIK3CA, RAET1L, ULBP2, PPP3CA, PPP3CC, PIK3CB, TNFRSF10B, VAV3, HRAS, PIK3R1, ICAM1, LCP2, ICAM2, SYK, PIK3R2, PTK2B, PIK3CD, RAC2, NFATC4",0.530177984021837,0.209011524911184,FALSE +"H1703","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.50978,1.58,0.0526,1974,0.56,"GRIN1, CTSG, NR3C1, TACR1, PLG, PRSS1, HRH1",1.27901425584626,0.2518119729938,FALSE +"H1703","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.24435,0.754,0.769,2459,0.963,"NGFR, MAPK7, CRK, SHC1, ATF4, NFKBIE, YWHAH, MAPK9, RPS6KA1, MAPK10, FOXO3, YWHAE, NFKBIB, PLCG2, RAF1, RELA, CRKL, MAPK8, RPS6KA2, KIDINS220, YWHAG, AKT1, YWHAQ, CAMK2G, MAPK12, YWHAB, CALML3, BAX, MAP2K2, NFKB1, BAD",0.114073660198569,0.0163737128754655,FALSE +"H1703","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.3463,-1.02,0.392,7317,0.654,"PNP, QPRT, NT5C3A, CD38, NT5E, NNT",0.406713932979543,0.184422251675733,FALSE +"H1703","Input","KEGG_NITROGEN_METABOLISM",0.38064,1.17,0.262,308,0.926,"GLUL, CA13, ASNS, GLUD2",0.581698708680255,0.0333890133180656,FALSE +"H1703","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.41018,-1.23,0.202,8387,0.573,"TRAF6, MAPK13, IL6, PYCARD, CASP1, TRIP6, CXCL1",0.694648630553376,0.24184537803261,FALSE +"H1703","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.45191,1.36,0.126,2726,0.7,"MRE11, XRCC4, LIG4, RAD50, POLL",0.899629454882437,0.154901959985743,FALSE +"H1703","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.27123,-0.803,0.72,7005,0.929,"TP53, PIK3CA, TGFA, CDK4, RXRA, PIK3CB, PDPK1, HRAS, PIK3R1, PIK3R2, PIK3CD, CCND1",0.142667503568732,0.0319842860063582,FALSE +"H1703","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.26355,0.797,0.693,869,0.945,"NOTCH3, DVL2, NUMBL, PSEN2, MAML2",0.159266765388193,0.0245681914907371,FALSE +"H1703","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.19425,-0.575,0.981,6228,1,"CCNH, MNAT1, RFC1, DDB2, XPC, GTF2H5, GTF2H4, CDK7, POLE4, ERCC2, ERCC3, GTF2H2, GTF2H3, ERCC5, GTF2H1",0.0083309926200515,0,FALSE +"H1703","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.45106,-1.33,0.135,5851,0.518,"MGAT1, ALG11, DAD1, DDOST, TUSC3, RPN2, ALG14, DPM3, ALG1, MGAT3, MGAT2, ALG9, MOGS, MAN2A1, MAN2A2, MAN1A1, MAN1A2, MAN1B1, B4GALT3, DOLPP1, FUT8, MGAT5, B4GALT1",0.869666231504994,0.285670240254767,FALSE +"H1703","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.23261,-0.701,0.859,6762,0.977,"PDC, CNGB1, CAMK2D, PRKG1",0.0660068361687577,0.0101054362812269,FALSE +"H1703","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.36991,1.12,0.267,1729,0.883,"MTHFD1L, ATIC, GART, SHMT1",0.573488738635425,0.0540392964224314,FALSE +"H1703","Input","KEGG_OOCYTE_MEIOSIS",0.17911,0.546,0.984,2435,1,"CDC25C, PTTG1, YWHAH, RPS6KA1, ITPR2, YWHAE, PPP2R5D, BTRC, ESPL1, CDC26, PRKACA, RPS6KA2, FBXW11, YWHAG, MOS, YWHAQ, CAMK2G, MAPK12, YWHAB, CDK1, CALML3, ANAPC4",0.00700490156865849,0,FALSE +"H1703","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.31633,0.964,0.443,3060,0.859,"MAN2B2, AGA, HEXB, MAN2B1, HEXA",0.35359627377693,0.0660068361687577,FALSE +"H1703","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.36588,1.1,0.285,3387,0.824,"COX6A1, COX6C, LHPP, COX11, NDUFA4, COX7C, NDUFA11, COX15, NDUFA8, COX7A2, SDHA, SDHB, ATP5F1B, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, ATP5PD, UQCRQ, UQCRC1, NDUFA7, UQCRH, NDUFC1, NDUFB5, NDUFS5, NDUFA2, SDHD, NDUFB1, NDUFC2, COX5A, NDUFB10, NDUFS7, UQCRC2, ATP5PB, NDUFS8, NDUFV3, PPA1, ATP5F1D, COX7B, ATP5PF, UQCR10, ATP5ME",0.54515513999149,0.0840727883028842,FALSE +"H1703","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.73514,-2.2,0.00341,7562,0.163,"GALNT12, C1GALT1, B3GNT6, GALNT11, GALNT4, GALNT1, GALNT13, GALNT15, GALNT7, ST3GAL2, GALNT2, GCNT1, GALNT5, B4GALT5, GALNT3, GALNT6",2.4672456210075,0.787812395596042,TRUE +"H1703","Input","KEGG_P53_SIGNALING_PATHWAY",-0.28371,-0.847,0.648,7461,0.891,"CCNB2, CDK4, PMAIP1, TNFRSF10B, SFN, RCHY1, IGFBP3, THBS1, SERPINB5, CCND1, CDKN1A",0.188424994129407,0.0501222959631252,FALSE +"H1703","Input","KEGG_PANCREATIC_CANCER",-0.26446,-0.796,0.728,7005,0.932,"TP53, RAC3, RAD51, PIK3CA, TGFA, JAK1, CDK4, PIK3CB, TGFB3, TGFBR1, RALB, VEGFC, BCL2L1, PIK3R1, PIK3R2, VEGFA, PIK3CD, TGFB2, RAC2, CCND1",0.137868620686963,0.0305840876460186,FALSE +"H1703","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.23482,-0.685,0.864,2169,0.99,"PPCS, PPCDC, PANK2, DPYD, COASY, PANK4, BCAT2",0.0634862575211067,0.00436480540245009,FALSE +"H1703","Input","KEGG_PARKINSONS_DISEASE",0.4569,1.38,0.123,3141,0.778,"UCHL1, UBE2G1, SLC18A1, COX6A1, UBE2L6, COX6C, NDUFA4, COX7C, NDUFA8, COX7A2, CASP9, SDHA, SDHB, ATP5F1B, UBE2L3, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, PPID, CYC1, COX4I1, PARK7, UQCRFS1, COX7A2L, COX6B1, LRRK2, ATP5PD, UQCRQ, UQCRC1, CASP3, NDUFA7, UQCRH, NDUFC1, NDUFB5, NDUFS5, CYCS, NDUFA2, SDHD, VDAC1, NDUFB1, NDUFC2, COX5A, NDUFB10, NDUFS7, UQCRC2, ATP5PB, NDUFS8, NDUFV3",0.910094888560602,0.109020403010311,FALSE +"H1703","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.33129,-0.99,0.431,8560,0.694,"ARPC1A, HCLS1, CTNNB1, TUBA4A, WAS",0.365522729839268,0.158640529545145,FALSE +"H1703","Input","KEGG_PATHWAYS_IN_CANCER",-0.24668,-0.72,0.813,7516,0.956,"SKP2, TPR, CDK4, RXRA, CTNNA2, PIK3CB, TGFB3, TGFBR1, RALB, APC, PAX8, VEGFC, ITGA6, HSP90B1, CTNNA1, BCL2L1, HRAS, MITF, PIK3R1, PDGFRB, CBLB, TRAF6, LAMB3, LAMC2, IL6, CTNNB1, PIK3R2, LAMA3, LAMA4, FN1, VEGFA, LAMB1, PIK3CD, MECOM, TGFB2, IGF1R, RAC2, ITGA2, MMP2, CCND1, RUNX1, SLC2A1, CDKN1A, PTGS2",0.0899094544059319,0.0195421077238999,FALSE +"H1703","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.3191,0.966,0.421,2088,0.878,"RPE, AKR1B1, CRYL1, XYLB",0.375717904164332,0.0565054840938974,FALSE +"H1703","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.27783,0.86,0.585,1399,0.937,"PGLS, DERA, PRPS1, PRPS1L1, PGD, RPE, PGM1",0.23284413391782,0.0282604091122217,FALSE +"H1703","Input","KEGG_PEROXISOME",-0.35685,-1.05,0.365,7236,0.657,"NUDT19, ACOX3, ACSL5, PEX11B, ACSL1, ACOX1, ACSL3, MLYCD, ABCD4, ACOT8, MVK, ACSL6, PXMP2, PEX12, AMACR, PEX13, ABCD3, CROT, ACOX2, CAT, CRAT, ACSL4, FAR1, EPHX2, SLC27A2",0.437707135543525,0.182434630440219,FALSE +"H1703","Input","KEGG_PHENYLALANINE_METABOLISM",-0.35798,-1.04,0.385,7974,0.656,"ALDH1A3, PAH, ALDH3A1, MAOA",0.414539270491499,0.18309616062434,FALSE +"H1703","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.26122,-0.774,0.731,7140,0.921,"PLCB4, PIK3CA, DGKZ, INPP5A, PIP4K2A, PIK3CB, ITPR3, PI4KA, ITPK1, PIP5K1C, PIK3R1, PIK3C2A, PIK3R2, DGKA, DGKB, PIK3CD, INPP5D",0.13608262304214,0.0357403698031511,FALSE +"H1703","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.61064,1.89,0.024,1405,0.474,"HMOX1, FECH, UROS, BLVRA, HMBS, COX15, BLVRB, CP",1.61978875828839,0.324221658325915,FALSE +"H1703","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.5948,-1.76,0.0238,7193,0.272,"CPT2, ACOX3, ACSL5, ACSL1, ACOX1, ACSL3, GK, RXRA, PDPK1, ILK, ACSL6, SLC27A4, ACOX2, FABP1, ACSL4, FABP3, PCK1, CYP27A1, FABP2, LPL, HMGCS2, CD36, FADS2, APOC3, SLC27A2, FABP7, ME1",1.62342304294349,0.565431095965801,FALSE +"H1703","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.55766,-1.69,0.0411,7947,0.305,"AMACR, ACOX2, CYP27A1, AKR1D1",1.38615817812393,0.515700160653214,FALSE +"H1703","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.70651,2.2,0.00487,929,0.319,"CD40, TAP1, ADA, RFXAP, TAP2, RFXANK, IKBKG",2.31247103878537,0.496209316942819,FALSE +"H1703","Input","KEGG_PRION_DISEASES",-0.25636,-0.755,0.765,8198,0.916,"C9, IL6, NCAM1",0.116338564846382,0.0381045263321496,FALSE +"H1703","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.22266,-0.646,0.912,7461,0.989,"CCNB2, PIK3CB, GNAI1, BUB1, ADCY9, PIK3R1, MAPK13, PIK3R2, PIK3CD, IGF1R",0.0400051616715838,0.0048037084028206,FALSE +"H1703","Input","KEGG_PROPANOATE_METABOLISM",0.32583,1,0.4,387,0.959,"ALDH3A2, LDHB, ACACB, ACACA",0.397940008672038,0.0181813928293364,FALSE +"H1703","Input","KEGG_PROSTATE_CANCER",0.22788,0.704,0.84,587,0.975,"PDGFRA, GSTP1, ATF4, E2F3, PDGFC, RB1",0.0757207139381184,0.0109953843014632,FALSE +"H1703","Input","KEGG_PROTEASOME",0.26847,0.825,0.648,695,0.978,"PSMB9, SEM1, PSMB8, PSMB10",0.188424994129407,0.00966114521239857,FALSE +"H1703","Input","KEGG_PROTEIN_EXPORT",-0.36121,-1.09,0.322,6678,0.623,"SEC11A, SEC61A1, HSPA5, SPCS2, SPCS3, SEC11C, SPCS1",0.492144128304169,0.20551195334083,FALSE +"H1703","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.56241,-1.64,0.0503,8281,0.345,"ATP1A2, GLS, GLS2, PCK1, AQP1, SLC38A3",1.29843201494407,0.462180904926726,FALSE +"H1703","Input","KEGG_PURINE_METABOLISM",0.22486,0.697,0.857,2422,0.954,"PFAS, ADK, PDE6C, NME1, ADA, RRM2B, NUDT9, NUDT5, NT5C2, PRPS1, PRPS1L1, NME2, IMPDH2, NME3, ATIC, HPRT1, ADSL, GART, PAPSS2, DCK, POLD4, GMPS, PRPS2, GUK1, NUDT2, APRT, NME4, ITPA, NT5C, POLA2, FHIT, POLA1, POLR3G, PAICS",0.0670191780768018,0.0204516252959049,FALSE +"H1703","Input","KEGG_PYRIMIDINE_METABOLISM",0.21544,0.654,0.914,2369,0.981,"UPP1, TXNRD1, UPRT, NME1, RRM2B, NT5C2, NME2, NME3, DTYMK, CAD, DUT, DCK, DCTD, TK1, TK2, POLD4, NUDT2, NME4, ITPA, NT5C, POLA2, POLA1, POLR3G",0.0390538042661686,0.0083309926200515,FALSE +"H1703","Input","KEGG_PYRUVATE_METABOLISM",0.32341,0.981,0.43,1365,0.891,"ALDH3A2, LDHB, ACACB, ACACA, ME2, ACYP1, ACAT1, ACYP2, GLO1, AKR1B1",0.366531544420413,0.0501222959631252,FALSE +"H1703","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.29383,-0.861,0.613,8034,0.895,"MYH14, HRAS, PIP5K1C, ITGA1, IQGAP3, ITGA4, PIK3R1, PDGFRB, ITGB6, ITGB4, RRAS2, ARPC1A, ITGA7, PIK3R2, IQGAP2, ACTN4, SLC9A1, FN1, SCIN, ITGB3, PIK3CD, RAC2, ITGA2, WAS, ITGB8",0.212539525481585,0.048176964684088,FALSE +"H1703","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.44189,1.31,0.172,1681,0.766,"ATG12, ATG5, GABARAPL1, PIK3C3, ATG7, PIK3R4",0.764471553092451,0.115771230367396,FALSE +"H1703","Input","KEGG_RENAL_CELL_CARCINOMA",-0.25915,-0.761,0.763,6518,0.915,"JUN, HGF, SOS1, RAPGEF1, CREBBP, RAP1B, PIK3CA, MET, PAK4, TGFA, RAP1A, PIK3CB, TGFB3, VEGFC, HRAS, PIK3R1, PIK3R2, VEGFA, PIK3CD, TGFB2, SLC2A1",0.11747546204512,0.0385789059335517,FALSE +"H1703","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.39302,-1.18,0.222,7917,0.535,"MME, ACE, ANPEP",0.653647025549361,0.271646217978772,FALSE +"H1703","Input","KEGG_RETINOL_METABOLISM",-0.45263,-1.34,0.127,8665,0.537,"DGAT1, PNPLA4, DHRS3, RDH10",0.896196279044043,0.270025714300444,FALSE +"H1703","Input","KEGG_RIBOFLAVIN_METABOLISM",0.64005,1.99,0.00709,1663,0.455,"ACP6, PHPT1, MTMR6",2.14935376481693,0.341988603342888,FALSE +"H1703","Input","KEGG_RIBOSOME",0.12821,0.378,1,6734,1,"RPS4Y1, RPS29, RPL37, RPL38, RPS21, RPS12, RPS28, RPS3, RPL24, RSL24D1, RPS10, RPL17, RPL36A, RPL36AL, UBA52, RPS5, RPSA, RPS19, RPL10A, FAU, RPL18, RPL12, RPL13A, RPL29, RPS17, RPL35A, RPS15A, RPS15, RPL23, RPS27L, RPL30, RPLP0, RPS9, RPS13, RPL9, RPL22, RPL18A, RPS16, RPS2, RPL3, RPLP1, RPS20, RPL28, RPS24, RPL10, RPL15, RPL6, RPL11, RPL27, RPL7A, RPL4, RPS11, RPL8, RPL26, RPS27A, RPL31, RPL7, RPL34, RPS4X, RPLP2, RPS25, RPL36, RPS23, RPL27A, RPS7, RPL23A, RPS18, RPS8, RPS26, RPL21, MRPL13, RPL13, RPL26L1, RPS3A, RPL5, RPL19, RPL35, RPL37A, RPL32",0,0,FALSE +"H1703","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.45927,1.43,0.102,2218,0.723,"DDX3Y, AZI2, ATG12, TBKBP1, MAPK9, RIPK1, MAPK10, IKBKG, NFKBIB, RELA, MAP3K7, ATG5, MAPK8, TBK1, DHX58, TANK, TRAF2, SIKE1, IRF3, TRADD, MAPK12",0.991399828238082,0.140861702705469,FALSE +"H1703","Input","KEGG_RNA_DEGRADATION",0.1837,0.557,0.977,1959,1,"LSM1, ENO1, DCP1B, ENO3, HSPA9, XRN1, LSM6, DCP2, LSM2, LSM7, LSM3",0.0101054362812269,0,FALSE +"H1703","Input","KEGG_RNA_POLYMERASE",-0.42494,-1.27,0.168,5770,0.597,"POLR2B, POLR3C, POLR2I, POLR2E, POLR2D, POLR2L, POLR1E, POLR2F, POLR3D, POLR3H, POLR3A, POLR3K, POLR3B",0.774690718274137,0.224025668870631,FALSE +"H1703","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.38246,-1.14,0.29,8174,0.585,"GGT7, GGT5, MARS2, CTH",0.537602002101044,0.23284413391782,FALSE +"H1703","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.42096,-1.25,0.19,7516,0.582,"SKP2, CDK4, RXRA, PIK3CB, ITGA6, BCL2L1, PIK3R1, TRAF6, LAMB3, LAMC2, PIK3R2, LAMA3, LAMA4, FN1, LAMB1, PIK3CD, ITGA2, CCND1, PTGS2",0.721246399047171,0.235077015350112,FALSE +"H1703","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.54227,-1.61,0.0551,7091,0.363,"STX12, STX16, GOSR1, VTI1A, STX5, VAMP4, STX10, STX18, SEC22B, SNAP23, STX3, BET1L, VAMP5, VAMP8",1.25884840114821,0.440093374963888,FALSE +"H1703","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.2792,-0.84,0.637,8252,0.895,"SMPD1, ASAH1, PLPP3, SMPD3",0.19586056766465,0.048176964684088,FALSE +"H1703","Input","KEGG_SPLICEOSOME",0.3247,0.993,0.415,3774,0.916,"WBP11, PQBP1, ZMAT2, LSM6, SF3B4, SLU7, RBM8A, DHX8, CHERP, LSM2, PPIL1, LSM7, LSM3, HSPA1A, SNW1, LSM4, SMNDC1, HSPA6, SNRNP40, ACIN1, SF3A2, HSPA2, PRPF8, CDC40, SNRNP70, SRSF5, CWC15, ISY1, THOC2, SYF2, THOC1, AQR, MAGOHB, TCERG1, U2AF1, SNRNP27, U2AF2, TXNL4A, HNRNPC, SNRPC, PPIH, ALYREF, HSPA1L, RBMX, THOC3, EFTUD2, CCDC12, PPIE, RBM17, SNRPG, SART1, BUD31, SRSF9, SNRPF, HSPA8, DDX23, BCAS2, PRPF3, SRSF2, SRSF1, LSM8",0.381951903287907,0.0381045263321496,FALSE +"H1703","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.32918,-0.971,0.461,5743,0.713,"GCK, HK2, PYGB, GBE1, AGL, GAA, PGM2, HK3, GYS1, UXS1, MGAM, UGDH, PGM2L1",0.336299074610352,0.146910470148134,FALSE +"H1703","Input","KEGG_STEROID_BIOSYNTHESIS",-0.64893,-1.9,0.0157,7678,0.194,"SC5D, LSS, DHCR7, HSD17B7, DHCR24, SQLE, MSMO1, CYP51A1, FDFT1, TM7SF2",1.80410034759077,0.712198270069774,TRUE +"H1703","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.70082,-2.09,0.00347,6972,0.112,"HSD11B2, SRD5A3, AKR1C3, STS, HSD17B7, AKR1C1, HSD17B12, CYP21A2, AKR1D1, HSD17B8",2.45967052520913,0.950781977329818,TRUE +"H1703","Input","KEGG_SULFUR_METABOLISM",-0.35586,-1.04,0.361,8090,0.656,"CHST11, SULT1A3",0.442492798094342,0.18309616062434,FALSE +"H1703","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.41474,1.3,0.157,14,0.738,"CD40",0.804100347590766,0.131943638176958,FALSE +"H1703","Input","KEGG_TASTE_TRANSDUCTION",-0.32505,-0.947,0.496,7312,0.741,"GNB1, GNB3, GNAS, ITPR3",0.304518323509803,0.130181792020672,FALSE +"H1703","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.36951,-1.09,0.333,7734,0.623,"MVK, HMGCR, HMGCS1, HMGCS2",0.47755576649368,0.20551195334083,FALSE +"H1703","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.20776,0.646,0.918,1281,0.976,"TGFBR2, ZFYVE16, E2F5, RPS6KB1, TGFB1, AMH, SMAD4",0.0371573187987575,0.0105501823333082,FALSE +"H1703","Input","KEGG_THYROID_CANCER",-0.40355,-1.22,0.196,7005,0.549,"TP53, MYC, TCF7L2, TPR, RXRA, PAX8, HRAS, CTNNB1, CCND1",0.707743928643524,0.260427655549908,FALSE +"H1703","Input","KEGG_TIGHT_JUNCTION",-0.34659,-1.02,0.388,7360,0.654,"PPP2R2A, PRKCD, PPP2R2B, CDK4, RAB3B, PRKCI, CTNNA2, JAM2, GNAI1, PARD6B, CTNNA1, CASK, MYH14, MYH7B, HRAS, SPTAN1, PARD6G, RRAS2, CLDN7, HCLS1, CTNNB1, ACTN4, CLDN3, LLGL2, TJP2, EPB41L3, EPB41L1, F11R",0.411168274405793,0.184422251675733,FALSE +"H1703","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.28064,0.868,0.581,1854,0.984,"CD40, TLR3, CTSK, MAPK9, RIPK1, MAP2K4, MAPK10, IKBKG, MYD88, RELA, MAP3K7, MAPK8, TAB2, TAB1, TBK1",0.235823867609669,0.00700490156865849,FALSE +"H1703","Input","KEGG_TRYPTOPHAN_METABOLISM",0.45205,1.37,0.138,325,0.734,"KYNU, ALDH3A2, MAOB",0.860120913598763,0.134303940083929,FALSE +"H1703","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.38145,-1.14,0.257,6958,0.585,"HK3, PIK3CA, PKM, PRKCD, IRS2, PIK3CB, PDX1, PIK3R1, IRS1, PIK3R2, PIK3CD",0.590066876668705,0.23284413391782,FALSE +"H1703","Input","KEGG_TYROSINE_METABOLISM",0.335,1.03,0.391,2077,0.942,"MAOB, FAH, PNMT, GSTZ1, MIF, ADH5, GOT1, LCMT1, DCT",0.407823242604133,0.0259490972071227,FALSE +"H1703","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.2842,-0.851,0.638,7033,0.894,"PTPN6, PPP3R1, PIK3CA, PAK4, TEC, PPP3CA, PPP3CC, CDK4, PIK3CB, MAP2K7, PDPK1, VAV3, PTPRC, HRAS, PIK3R1, CBLB, DLG1, MAPK13, LCP2, PIK3R2, PIK3CD, NFATC4",0.195179321278838,0.0486624812040823,FALSE +"H1703","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.25608,0.779,0.724,2750,0.947,"FBXO2, HERC4, VHL, UBE2G1, UBE2L6, FBXW7, ERCC8, XIAP, UBE2E1, UBE2R2, CUL4B, BIRC6, BTRC, UBE2K, UBE2L3, UBE2E2, CDC26, NEDD4L, CUL4A, CUL3, UBE3B, UBE2A, UBE2M, UBE2D4, FBXW11, PIAS4, FBXW8, CUL7, UBE2D2, SMURF2, ANAPC4, PIAS2, SAE1, NEDD4, UBE2H, SKP1, ELOB, UBA6, CUL1",0.140261433802853,0.0236500209967266,FALSE +"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.26856,-0.787,0.728,2481,0.918,"VARS2, IARS2, PDHB, PDHA1, LARS2, BCAT2",0.137868620686963,0.0371573187987575,FALSE +"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.33257,-0.994,0.433,7790,0.696,"BCAT2, HMGCS1, HIBCH, DBT, ABAT, HMGCS2, ALDH6A1, ACADS",0.363512103646635,0.157390760389438,FALSE +"H1703","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.21836,-0.642,0.943,7041,0.984,"PLA2G12A, PLCB4, MYLK3, ARHGEF12, GNA12, GUCY1A1, PRKCD, MYLK, GNA11, GNAS, PLA2G4A, ITPR3, PPP1R12B, ADCY9, PRKG1",0.0254883072626717,0.00700490156865849,FALSE +"H1703","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.33192,1.02,0.376,1667,0.935,"DYNC1I2, DYNC1I1, DYNC1LI1, DCTN6, DCTN5, DYNC1LI2, DCTN4, DYNC1H1, DYNC2LI1, DCTN2, PRKACA",0.424812155072339,0.0291883891274822,FALSE +"H1703","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.41155,-1.22,0.203,7041,0.549,"PLA2G12A, PTK2, RAC3, PPP3R1, PIK3CA, PPP3CA, PPP3CC, PIK3CB, PLA2G4A, HRAS, PIK3R1, MAPK13, PIK3R2, VEGFA, PIK3CD, RAC2, NFATC4, PTGS2",0.692503962086787,0.260427655549908,FALSE +"H1703","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.43289,-1.25,0.166,6031,0.582,"ATP6V1F, SLC12A2, SEC61B, ATP6V1E1, TJP1, ATP6V1A, ATP6V1C2, SEC61A1, ATP6V0A2, ATP6V0C, ATP6V1B2, ATP6V0D1, ATP6V1G2, TCIRG1, ATP6V1D, ATP6V1B1, ATP6V1H, GNAS, PDIA4, ERO1A, ADCY9, TJP2",0.779891911959945,0.235077015350112,FALSE +"H1703","Input","KEGG_VIRAL_MYOCARDITIS",0.33545,1.03,0.359,1754,0.942,"CD40, CAV1, CXADR, MYH3, CASP9, SGCB, BID, DAG1, MYH10, MYH11, MYH9",0.444905551421681,0.0259490972071227,FALSE +"H1703","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.26004,-0.778,0.755,6430,0.925,"PPP2R5B, PPP2R1B, TBL1XR1, TCF7L1, JUN, CTBP2, VANGL1, CSNK1A1, PPP2R5E, CREBBP, DVL3, TP53, DVL1, RAC3, PPP3R1, MYC, PLCB4, WNT5A, PPP2CB, TCF7L2, CCND3, PPP3CA, TBL1X, PPP3CC, CAMK2D, APC, CSNK1E, FOSL1, SOX17, PPP2R5C, SENP2, DAAM1, CTNNB1, RAC2, NFATC4, CCND1",0.122053048370812,0.0338582672609674,FALSE +"H460","Input","KEGG_ABC_TRANSPORTERS",0.55065,1.74,0.0416,931,0.202,"ABCG2, ABCC2, ABCC3, ABCB6, ABCB10, ABCD4, ABCG1, ABCA3",1.38090666937326,0.694648630553376,TRUE +"H460","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.53944,-1.76,0.0463,6979,0.645,"MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, IKBKB, RPS6KB2, TCF7L2, MAPK1, RARA, PIK3R2, RAF1, RELA, STAT5A, MAPK3, RPS6KB1, AKT2, STAT5B, EIF4EBP1, STAT3",1.33441900898205,0.190440285364732,FALSE +"H460","Input","KEGG_ADHERENS_JUNCTION",-0.24556,-0.789,0.695,6894,0.807,"FER, FARP2, PTPN1, RHOA, VCL, CDH1, CDC42, TCF7L2, LMO7, MAPK1, NLK, PTPRF, MAPK3, RAC2, BAIAP2, WASL, NECTIN4, PTPN6",0.158015195409886,0.0931264652779296,FALSE +"H460","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.29557,-0.959,0.437,5653,0.601,"NFKBIB, PRKAA1, NFKB1, RXRA, MTOR, ACSL3, CAMKK2, AKT3, CHUK, PRKAG1, CPT1A, PTPN11, RXRB, PRKAG2, RXRG, AKT1, PRKCQ, STK11, IKBKB, CD36, RELA, ACACB, AKT2, IRS1, STAT3",0.359518563029578,0.22112552799726,FALSE +"H460","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.26943,0.878,0.575,1174,0.733,"CPS1, GLS, GLS2, GPT2",0.24033215531037,0.134896025358872,FALSE +"H460","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.30467,-0.976,0.437,6398,0.604,"KRAS, ATP1A4, ATP1A1, ATP1A3, NEDD4L, PIK3CA, PIK3CB, MAPK1, PIK3R2, MAPK3, IRS1",0.359518563029578,0.218963061378868,FALSE +"H460","Input","KEGG_ALZHEIMERS_DISEASE",0.41924,1.36,0.145,2562,0.411,"ATP5PF, ITPR1, NDUFS6, ATP5PD, HSD17B10, UQCRH, CASP7, ATP5F1D, PLCB4, NDUFA2, NDUFS8, SNCA, NDUFA8, TNFRSF1A, NDUFV2, UQCRFS1, UQCRB, NDUFS4, ATP5F1B, APP, NDUFA7, COX5B, COX6B1, COX6A1, NDUFS1, UQCRC1, NDUFA5, ADAM17, NDUFA3, NCSTN, ERN1, CYCS, NDUFV3, SDHB, COX5A, CYC1, NDUFS3, CALM2, NDUFB8, ATP5F1E, ATP5PB, GNAQ, SDHA, NDUFB2, UQCRC2, COX7A2, NDUFA4, COX7C, NDUFV1, ATP5MC2, UQCR10, SDHC, NDUFS5, NDUFAB1, NDUFB3, NDUFC1, ADAM10, ATP5F1A, ATP5PO, LRP1, NDUFB6, NDUFA4L2",0.838631997765025,0.386158178123931,FALSE +"H460","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.37902,-1.23,0.207,4549,0.435,"YARS2, HARS2, MARS2, CARS2, NARS2, SARS2, WARS2, MTFMT, FARSB, TARS2, PARS2, VARS2, FARSA, SEPSECS",0.684029654543082,0.361510743045363,FALSE +"H460","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.48321,-1.55,0.0805,6657,0.393,"PMM1, HK2, GMDS, PGM2, UGP2, MPI, NAGK, NANP, GNPDA1, GPI, HK1, AMDHD2, FPGT, GNPNAT1, GALT, GALE, RENBP, PGM3, PGM1, UAP1",1.09420411963213,0.405607449624573,FALSE +"H460","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.33907,-1.1,0.302,7391,0.49,"CAT, GRIN1, DAXX, PPP3CA, MAPK14, APAF1, CASP1, PPP3CB, MAPK13, MAPK12",0.519993057042849,0.309803919971486,FALSE +"H460","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.33315,1.09,0.313,1319,0.584,"CTSL, B2M, HSPA5, PDIA3, NFYB, CTSB, RFXANK",0.504455662453552,0.233587152887601,FALSE +"H460","Input","KEGG_APOPTOSIS",-0.23443,-0.742,0.775,7393,0.844,"PIK3CB, AKT1, IRAK4, CASP6, IKBKB, PPP3CA, RIPK1, CAPN2, PIK3R2, RELA, APAF1, PPP3CB, AKT2, CAPN1",0.11069829749369,0.073657553374345,FALSE +"H460","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.34082,1.11,0.308,419,0.596,"GGT1, AKR1C3, PTGES",0.511449283499556,0.224753740259764,FALSE +"H460","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.30204,-0.967,0.45,7377,0.611,"AMD1, SMS, ASL, CKMT1A, PRODH, PRODH2, CKB, ARG2, ARG1, GATM, AOC1, DAO, GLUD2",0.346787486224656,0.213958789757446,FALSE +"H460","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.41446,1.32,0.149,1073,0.398,"CACNA2D1, ITGB5, DSC2, ITGAV, ITGA5, DES, LMNA, DAG1, DSG2, SGCD, ITGA6",0.826813731587726,0.400116927926312,FALSE +"H460","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.7103,2.24,0,230,0.0954,"UGDH",Inf,1.0204516252959,TRUE +"H460","Input","KEGG_AXON_GUIDANCE",-0.37722,-1.21,0.217,7073,0.446,"PLXNC1, PAK3, ROCK1, NFATC3, RHOA, EPHA2, PAK1, PTK2, CDK5, ROCK2, PAK4, GSK3B, CFL1, ARHGEF12, CDC42, PPP3CA, NFAT5, RASA1, EFNB2, MAPK1, SLIT2, ABLIM1, PAK2, SEMA3C, MAPK3, RAC2, EPHB3, PPP3CB, NTN1, RHOD, NGEF, NFATC2, EPHB2",0.66354026615147,0.350665141287858,FALSE +"H460","Input","KEGG_BASAL_CELL_CARCINOMA",-0.22181,-0.723,0.82,6274,0.84,"FZD7, CTNNB1, STK36, GSK3B, DVL3, TCF7L2",0.0861861476162833,0.0757207139381184,FALSE +"H460","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.36423,1.17,0.241,2507,0.525,"TAF13, GTF2A2, TAF12, TAF10, GTF2E2, GTF2A1, TAF5L, GTF2H1, TAF1, TAF6L, TAF6, TAF9, TAF4, TAF7, GTF2F2",0.617982957425132,0.279840696594043,FALSE +"H460","Input","KEGG_BASE_EXCISION_REPAIR",0.19161,0.608,0.94,7077,0.977,"NTHL1, TDG, PARP2, POLD4, LIG3, PARP1, POLE3, XRCC1, MPG, POLD2, POLE4, POLB, FEN1, PCNA, POLD1, APEX1, POLD3, PARP4, MBD4, POLE, LIG1, UNG, HMGB1",0.0268721464003014,0.0101054362812269,FALSE +"H460","Input","KEGG_BETA_ALANINE_METABOLISM",-0.29499,-0.963,0.434,6104,0.61,"MLYCD, ABAT, EHHADH, SMS, DPYD",0.362510270487489,0.214670164989233,FALSE +"H460","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.22426,-0.728,0.795,7093,0.841,"HACD2, TECR, ACOT7",0.0996328713435297,0.0752040042020878,FALSE +"H460","Input","KEGG_BLADDER_CANCER",-0.34042,-1.1,0.295,6398,0.49,"KRAS, NRAS, MAP2K2, CDK4, MAP2K1, CDH1, THBS1, MAPK1, DAPK1, RAF1, MAPK3",0.530177984021837,0.309803919971486,FALSE +"H460","Input","KEGG_BUTANOATE_METABOLISM",-0.3324,-1.08,0.333,7112,0.504,"AACS, EHHADH, BDH2, ACAT2, HMGCS2, ACSM3, HMGCS1, BDH1",0.47755576649368,0.297569463554475,FALSE +"H460","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.52543,-1.72,0.0391,6194,0.466,"AKT3, CHUK, KRAS, NRAS, BCL10, RAC1, MAP2K2, NFATC3, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, IKBKB, PPP3CA, NFAT5, PLCG2, MAPK1, SYK, PIK3R2, RAF1, RELA, MAPK3, RAC2, VAV2, PPP3CB, AKT2, PTPN6, NFATC2",1.40782324260413,0.33161408331,FALSE +"H460","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.28594,0.922,0.491,1201,0.704,"BST1, CACNA1A, ITPR1, CAMK2D, PLCB4, CAMK4, PLCD3, PRKCB, VDAC1, RYR1, PTK2B, ATP2B1",0.308918507877032,0.152427340857888,FALSE +"H460","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.45636,1.47,0.1,2271,0.37,"CACNA2D1, UQCRH, UQCRFS1, UQCRB, ATP1A2, COX5B, COX6B1, COX6A1, UQCRC1, COX5A, CYC1, SLC8A1, UQCRC2, TPM4, COX7A2, COX7C, TPM3, TPM1, UQCR10",1,0.431798275933005,FALSE +"H460","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.56014,1.81,0.0314,456,0.262,"SDC2, NRCAM, PTPRM, CD274, NCAM2, NCAM1, CD99, L1CAM, CNTN1, PDCD1LG2, JAM3, ITGAV, CD58",1.50307035192679,0.581698708680255,FALSE +"H460","Input","KEGG_CELL_CYCLE",-0.23427,-0.759,0.772,6113,0.833,"SMAD3, TFDP1, ORC2, ANAPC4, PRKDC, BUB1B, STAG2, RBL1, HDAC1, ABL1, BUB1, PLK1, CUL1, SMC3, CDK4, YWHAB, CDC45, STAG1, GSK3B, YWHAZ, FZR1, CHEK1, CDC23, CDC16, CDK1, CCNA2, CDK2, CCNB1, TTK, PTTG1, WEE1",0.112382699664264,0.0793549985932124,FALSE +"H460","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.41158,-1.32,0.148,6982,0.448,"HCK, GNG4, ROCK1, GRK6, MAP2K1, RHOA, PIK3CA, PAK1, SOS1, PTK2, ROCK2, PIK3CB, AKT1, GSK3B, PXN, IKBKB, CDC42, MAPK1, BCAR1, CCL15, PIK3R2, RAF1, RELA, CSK, MAPK3, RAC2, STAT1, VAV2, CCL13, GRK2, GSK3A, PRKCD, WASL, GNG5, AKT2, STAT5B, ARRB1, CCL14, STAT2, STAT3",0.829738284605043,0.348721986001856,FALSE +"H460","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.31495,-1.02,0.396,5735,0.553,"PIK3CD, CBL, NFKB1, TGFBR2, SMAD3, AKT3, CHUK, CBLB, KRAS, NRAS, CRKL, HDAC1, ABL1, MAP2K2, PTPN11, CDK4, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, IKBKB, MECOM, MAPK1, PIK3R2, RAF1, RELA, STAT5A, MAPK3, AKT2, STAT5B",0.402304814074488,0.257274868695302,FALSE +"H460","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.41577,1.35,0.137,2298,0.407,"PDHB, IDH3A, MDH2, SUCLG1, SUCLG2, PDHA1, SDHB, DLAT, DLST, PCK2, DLD, SDHA, ACO2, IDH3G, SDHC",0.863279432843593,0.39040559077478,FALSE +"H460","Input","KEGG_COLORECTAL_CANCER",-0.21976,-0.728,0.819,7147,0.841,"MAP2K1, RHOA, PIK3CA, PIK3CB, AKT1, GSK3B, TCF7L2, MAPK1, PIK3R2, RAF1, MAPK3, RAC2, AKT2",0.0867160982395816,0.0752040042020878,FALSE +"H460","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.41555,1.32,0.136,1265,0.398,"CD55, MBL2, PLAUR, F3, C9, F5, F8, PROS1, PLAU, C7",0.866461091629782,0.400116927926312,FALSE +"H460","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.3892,-1.31,0.161,5302,0.427,"SRM, APIP, AHCYL1, LDHB, LDHA, ENOPH1, DNMT1, GOT1, AMD1, SMS, CBS, ADI1, SDS, AHCY",0.79317412396815,0.369572124974976,FALSE +"H460","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.37916,1.24,0.18,618,0.479,"EPO, CXCL5, TNFRSF19, TNFRSF10A, TGFB2, TGFBR1, TNFRSF10B, TNFRSF1A, OSMR, CXCL6",0.744727494896694,0.319664486585437,FALSE +"H460","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.24465,-0.796,0.73,7666,0.812,"IKBKB, PYCARD, RIPK1, RELA, ZBP1, CASP1, IL18",0.136677139879544,0.0904439707588247,FALSE +"H460","Input","KEGG_DILATED_CARDIOMYOPATHY",0.42515,1.37,0.125,2322,0.417,"CACNA2D1, TGFB2, ITGB5, ITGAV, ITGA5, DES, LMNA, DAG1, SGCD, ITGA6, ITGA10, ACTG1, SLC8A1, TGFB1, EMD, ITGB1, TPM4, TPM3, GNAS, TPM1, ACTB",0.903089986991944,0.379863945026242,FALSE +"H460","Input","KEGG_DNA_REPLICATION",-0.19803,-0.631,0.915,4819,0.929,"POLD1, MCM2, RNASEH2B, MCM7, POLA1, POLD3, MCM4, MCM6, RNASEH1, PRIM1, POLE, RFC4, RFC2, LIG1, RFC3, RFC1, RFC5",0.0385789059335517,0.0319842860063582,FALSE +"H460","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.29715,0.95,0.458,1003,0.742,"NOTCH3, NOTCH1, NOTCH2",0.339134521996131,0.129596094720973,FALSE +"H460","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.39322,1.29,0.147,1773,0.422,"MGST1, GSTM4, GSTM1, ALDH3A1, GSTM2, MGST2, MAOA, ADH4, ADH7, GSTK1",0.832682665251824,0.374687549038326,FALSE +"H460","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.43429,-1.41,0.123,7379,0.468,"UPP1, HPRT1, NAT1, TK1, TK2, DPYD, TPMT, UCKL1",0.910094888560602,0.329754146925876,FALSE +"H460","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.55457,1.79,0.0266,818,0.22,"SDC2, COL5A2, FN1, SPP1, LAMB1, HSPG2, LAMA1, LAMC1, ITGB5, LAMA5, ITGAV, ITGA5, VTN, LAMB2, THBS3, DAG1, COL6A1, COL4A6",1.57511836336893,0.657577319177794,TRUE +"H460","Input","KEGG_ENDOCYTOSIS",-0.34822,-1.15,0.25,6029,0.479,"HSPA1A, DNM2, CHMP3, VPS4B, GIT2, VPS28, RAB5A, PARD6G, CBLB, SMAP2, IQSEC2, ARFGAP1, ARFGAP3, CHMP4A, CHMP4B, VPS25, CHMP4C, VPS37B, PIP5K1A, NEDD4L, EPS15, VTA1, RAB11A, SH3GL1, ITCH, GRK6, EHD1, EHD2, DAB2, RAB11FIP1, TRAF6, ARAP1, WWP1, IQSEC1, PDCD6IP, RAB5C, SH3GLB2, CDC42, ACAP2, SH3GLB1, CHMP2A, FGFR2, CLTC, ASAP1, SMURF2, EHD3, CHMP5, SMAP1, DNM1, LDLRAP1, CHMP2B, GRK2, ERBB3, PRKCI, ARFGAP2, ARRB1, ARAP3, DNM1L",0.602059991327962,0.319664486585437,FALSE +"H460","Input","KEGG_ENDOMETRIAL_CANCER",-0.3979,-1.26,0.198,6194,0.432,"AKT3, CTNNB1, KRAS, NRAS, MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, CDH1, TCF7L2, MAPK1, PIK3R2, RAF1, MAPK3, AKT2",0.703334809738469,0.364516253185088,FALSE +"H460","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.31666,-1.04,0.364,7666,0.544,"IKBKB, CDC42, PLCG2, F11R, PLCG1, MAPK14, RELA, CSK, MAPK13, MAP2K4, MAPK12",0.438898616350944,0.26440110030182,FALSE +"H460","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.42375,-1.36,0.128,6979,0.446,"MAP2K2, PAK3, MAP2K1, PIK3CA, PAK1, SOS1, PTK2, PAK4, PIK3CB, AKT1, GSK3B, GAB1, RPS6KB2, PLCG2, MAPK1, PLCG1, PAK2, PIK3R2, RAF1, STAT5A, MAPK3, RPS6KB1, ERBB3, AKT2, STAT5B, EIF4EBP1, MAP2K4, TGFA, ABL2",0.892790030352132,0.350665141287858,FALSE +"H460","Input","KEGG_ETHER_LIPID_METABOLISM",-0.23858,-0.791,0.717,7332,0.812,"PAFAH1B3, LPCAT4, PAFAH2, LPCAT2",0.1444808443322,0.0904439707588247,FALSE +"H460","Input","KEGG_FATTY_ACID_METABOLISM",0.25942,0.831,0.661,1769,0.782,"ACAA2, ACADSB, ECHS1, ACADS, ECI1, ACAT1, ADH4, ADH7",0.17979854051436,0.106793246940152,FALSE +"H460","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.48251,-1.57,0.0664,6979,0.387,"MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, PLCG2, MAPK1, PLCG1, SYK, MAPK14, PIK3R2, RAF1, MAPK3, RAC2, VAV2, PRKCD, AKT2, MAPK13, MAP2K4, MAPK12",1.17783192063198,0.412289034981089,FALSE +"H460","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.50299,-1.63,0.0441,6982,0.378,"HCK, ARPC1A, MAP2K1, PIK3CA, PAK1, PIK3CB, AKT1, ARPC4, ARPC3, CFL1, VASP, CDC42, RPS6KB2, PLCG2, SCIN, ARPC2, MAPK1, MYO10, PLCG1, SYK, PIK3R2, RAF1, ASAP1, MARCKSL1, MAPK3, RAC2, VAV2, GSN, DNM1, RPS6KB1, PRKCD, WASL, AKT2, PTPRC, MARCKS, DNM1L",1.35556141053216,0.422508200162775,FALSE +"H460","Input","KEGG_FOCAL_ADHESION",0.27835,0.928,0.522,472,0.707,"COL5A2, FN1, SPP1, LAMB1, PIK3R3, LAMA1, LAMC1, ITGB5, LAMA5, FLNB, ITGAV, ITGA5, VTN, CAV2, LAMB2, THBS3",0.282329496997738,0.150580586203101,FALSE +"H460","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.51655,-1.67,0.0513,7763,0.381,"DHFR, ALPG, ALPI, ALPP",1.28988263488818,0.419075024324381,FALSE +"H460","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.4599,-1.51,0.0848,6110,0.391,"MTMR1, ALDOC, PFKFB3, PFKP, PMM1, HK2, TPI1, GMDS, PFKM, MTMR6, MPI, HK1, FPGT, PFKFB2, PFKFB4, PFKL, FBP1",1.07160414774329,0.407823242604133,FALSE +"H460","Input","KEGG_GALACTOSE_METABOLISM",-0.41733,-1.34,0.132,6503,0.445,"PFKP, HK2, PFKM, PGM2, UGP2, MGAM, HK1, GALT, GALE, PGM1, PFKL",0.87942606879415,0.351639989019068,FALSE +"H460","Input","KEGG_GAP_JUNCTION",-0.3032,-0.985,0.441,5952,0.597,"ADCY5, TUBB4B, HTR2B, GNAI3, TUBB6, KRAS, NRAS, PRKACB, PLCB3, MAPK7, MAP2K2, MAP2K1, SOS1, TUBA1B, TUBB3, TUBB1, TUBB, MAPK1, TUBB2A, RAF1, CDK1, MAPK3, CSNK1D, TUBA1C",0.355561410532161,0.224025668870631,FALSE +"H460","Input","KEGG_GLIOMA",-0.34386,-1.1,0.303,6979,0.49,"MAP2K2, CDK4, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, PLCG2, MAPK1, PLCG1, PIK3R2, RAF1, MAPK3, AKT2, TGFA",0.518557371497695,0.309803919971486,FALSE +"H460","Input","KEGG_GLUTATHIONE_METABOLISM",0.24851,0.799,0.697,331,0.8,"MGST1, GGT1, GSTM4, GSTM1",0.156767221901991,0.0969100130080564,FALSE +"H460","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.28815,-0.926,0.49,8160,0.651,"DGKA, MGLL, DGKH",0.309803919971486,0.186419011431808,FALSE +"H460","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.34491,-1.11,0.285,7585,0.514,"LPCAT4, MBOAT2, MBOAT7, CHKB, DGKA, PCYT2, PEMT, LPCAT2, CHKA, DGKH",0.54515513999149,0.289036881004724,FALSE +"H460","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.32315,-1.06,0.359,6143,0.528,"PSPH, SARDH, DMGDH, SRR, SHMT1, CBS, SDS, GATM, DAO",0.444905551421681,0.277366077466188,FALSE +"H460","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.41707,-1.31,0.181,6301,0.427,"ALDOC, LDHA, GALM, PFKP, BPGM, HK2, PGAM1, PGAM4, TPI1, AKR1A1, PFKM, ADH5, PGM2, ACSS2, GPI, HK1, ADH1C, ALDH1A3, PKLR, PGM1, PFKL, FBP1, PKM",0.742321425130815,0.369572124974976,FALSE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.2905,0.934,0.495,6210,0.725,"CHPF2, CHST3, DSE, CHSY1, B3GAT3, CHPF, B4GALT7, XYLT2, B3GALT6",0.305394801066431,0.139661993429006,FALSE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.36162,-1.17,0.26,5838,0.467,"XYLT2, B3GALT6, EXTL3, NDST2, HS2ST1",0.585026652029182,0.330683119433888,FALSE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.26235,0.832,0.63,380,0.794,"ST3GAL2",0.200659450546418,0.100179497572904,FALSE +"H460","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.70444,2.25,0.00202,2263,0.139,"GNS, IDS, HEXB, HEXA, GLB1, ARSB, GUSB, IDUA, GALNS",2.69464863055338,0.856985199745905,TRUE +"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.64575,2.11,0,970,0.104,"B4GALNT1, ST3GAL2, HEXB, HEXA",Inf,0.98296666070122,TRUE +"H460","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.50746,-1.66,0.0396,5131,0.364,"PIGK, PIGT, GPAA1, PGAP1, PIGQ, PIGH, PIGM, PIGU",1.40230481407449,0.438898616350944,FALSE +"H460","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.23526,0.763,0.764,2095,0.852,"MTHFD2, MDH2, HAO1, ACO2",0.11690664142431,0.0695604052332999,FALSE +"H460","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.32237,-1.02,0.401,6398,0.553,"KRAS, NRAS, MAP3K3, PRKACB, PLCB3, MAPK7, MAP2K2, MAP2K1, SOS1, CDC42, MAPK1, MMP14, MAP3K4, MAPK14, RAF1, MAPK3, PRKCD, MAPK13, MAP2K4, MAPK12, MAP3K1",0.396855627379818,0.257274868695302,FALSE +"H460","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.33353,-1.08,0.33,7225,0.504,"STK36, GSK3B, CSNK1G2, BTRC, CSNK1A1, CSNK1D",0.481486060122112,0.297569463554475,FALSE +"H460","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.41187,1.32,0.153,454,0.398,"CD55, EPO, ITGA5, CD14",0.815308569182401,0.400116927926312,FALSE +"H460","Input","KEGG_HISTIDINE_METABOLISM",-0.40967,-1.31,0.167,7838,0.427,"TRMT11, METTL2B, LCMT1, ALDH1A3, HDC, AOC1",0.777283528852417,0.369572124974976,FALSE +"H460","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.31013,1.02,0.395,2061,0.669,"SSBP1, RAD51, RAD54L, MUS81, POLD4, MRE11",0.40340290437354,0.174573882232177,FALSE +"H460","Input","KEGG_HUNTINGTONS_DISEASE",0.4545,1.44,0.12,2579,0.365,"ATP5PF, ITPR1, NDUFS6, ATP5PD, UQCRH, ATP5F1D, PLCB4, NDUFA2, NDUFS8, POLR2H, NDUFA8, CLTA, SOD2, NDUFV2, UQCRFS1, UQCRB, NDUFS4, ATP5F1B, POLR2C, NDUFA7, COX5B, COX6B1, VDAC1, CLTB, COX6A1, POLR2L, NDUFS1, POLR2D, UQCRC1, NDUFA5, NDUFA3, POLR2E, CYCS, NDUFV3, SDHB, COX5A, CYC1, NDUFS3, AP2A2, NDUFB8, ATP5F1E, POLR2I, ATP5PB, GNAQ, POLR2F, SDHA, NDUFB2, UQCRC2, COX7A2, POLR2G, NDUFA4, COX7C, AP2A1, NDUFV1, ATP5MC2, UQCR10, SLC25A6, SDHC, NDUFS5, TAF4, NDUFAB1, NDUFB3, CREB5, NDUFC1, VDAC2, ATP5F1A, ATP5PO, NDUFB6, NDUFA4L2, SIN3A, SLC25A31",0.920818753952375,0.437707135543525,FALSE +"H460","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.43064,1.4,0.126,2003,0.395,"CACNA2D1, PRKAA2, TGFB2, ITGB5, ITGAV, ITGA5, DES, LMNA, DAG1, SGCD, ITGA6, ITGA10, ACTG1, SLC8A1, TGFB1, EMD, ITGB1, TPM4",0.899629454882437,0.40340290437354,FALSE +"H460","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.42467,-1.38,0.115,6275,0.462,"MINPP1, INPP5K, INPP4B, PIP4K2A, PIP5K1A, TPI1, PLCB3, PIK3CA, OCRL, PIK3CB, IMPA1, INPPL1, PLCG2, PLCG1, INPP1, INPP5B, PIK3C2B, SYNJ2, ISYNA1",0.939302159646388,0.335358024443874,FALSE +"H460","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.39645,-1.28,0.171,6303,0.435,"PPP1R3D, INPP5K, PRKAG1, CBLB, KRAS, NRAS, RHEB, CRKL, HK2, PRKACB, EXOC7, ACACA, FLOT2, MAP2K2, GYS1, PTPN1, MAP2K1, PRKAG2, PIK3CA, SOS1, PIK3CB, AKT1, RPS6, GSK3B, HK1, IKBKB, RPS6KB2, PHKG2, MAPK1, PIK3R2, RAF1, PTPRF, MAPK3, PKLR, RPS6KB1, ACACB, TSC2, AKT2, PRKCI, FBP1, EIF4EBP1, IRS1, MKNK1",0.767003889607846,0.361510743045363,FALSE +"H460","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.43838,-1.41,0.118,7000,0.468,"PTPN11, SPRY2, IRF9, PIK3CA, SOS1, IFNGR1, PIK3CB, AKT1, PIAS4, PIK3R2, STAT5A, STAT1, SPRY1, AKT2, STAT5B, SPRY4, PTPN6, STAT2, STAT3, PIAS2",0.928117992693875,0.329754146925876,FALSE +"H460","Input","KEGG_LEISHMANIA_INFECTION",-0.52159,-1.7,0.0263,7378,0.404,"IFNGR1, TAB2, IRAK4, TRAF6, ITGA4, MAPK1, MAPK14, RELA, C3, MARCKSL1, MAPK3, STAT1, MAPK13, PTPN6, MAPK12",1.58004425151024,0.393618634889395,FALSE +"H460","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.38753,-1.24,0.199,6642,0.431,"ICAM1, CDH5, RAC1, SIPA1, EZR, PTPN11, ROCK1, RHOA, PIK3CA, PTK2, ROCK2, PIK3CB, VCL, PXN, VASP, CDC42, PLCG2, F11R, ITGA4, ARHGAP5, BCAR1, PLCG1, MAPK14, PIK3R2, ARHGAP35, CLDN7, RAC2, VAV2, MAPK13, CLDN3, MAPK12, CLDN18",0.701146923590293,0.365522729839268,FALSE +"H460","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.29146,0.951,0.478,789,0.757,"ECHS1",0.320572103387881,0.120904120499927,FALSE +"H460","Input","KEGG_LONG_TERM_DEPRESSION",0.25071,0.813,0.683,951,0.801,"CACNA1A, ITPR1, PLCB4, PRKCB, RYR1",0.165579296318467,0.0963674839157623,FALSE +"H460","Input","KEGG_LONG_TERM_POTENTIATION",0.22627,0.738,0.775,725,0.84,"ITPR1, CAMK2D, PLCB4, CAMK4, PRKCB",0.11069829749369,0.0757207139381184,FALSE +"H460","Input","KEGG_LYSINE_DEGRADATION",0.22704,0.738,0.802,1837,0.84,"SETD7, ECHS1, ASH1L, SETMAR, KMT5C, ACAT1, DLST, EHMT2, TMLHE",0.0958256317158365,0.0757207139381184,FALSE +"H460","Input","KEGG_LYSOSOME",0.497,1.61,0.064,1208,0.257,"GALC, CTSL, CTSC, CTSZ, CTSV, AGA, GLA, GNS, ASAH1, PPT1, ARSA, IDS, LAMP2, IGF2R, LAMP3, HEXB, TCIRG1, CTSK, CTSO, CLTA, PPT2, CLN3, CLTB, GAA, LAMP1, NAGA, HEXA, PSAP, CTSB, CTSE, CTSF, M6PR, SCARB2",1.19382002601611,0.590066876668705,FALSE +"H460","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.34396,-1.11,0.294,5979,0.514,"PPM1A, MAP3K7, HSPA1A, TAOK2, DUSP3, RPS6KA4, CASP3, AKT3, TAB1, CHUK, MAP3K20, SRF, RPS6KA6, ELK4, TAOK3, KRAS, NRAS, MAPT, IL1A, CRKL, MAP3K3, PRKACB, RAC1, MAPK7, MAP2K2, DUSP1, PPM1B, RPS6KA1, MAP2K1, RELB, PAK1, SOS1, AKT1, TAB2, MAPKAPK2, TRAF6, DAXX, IKBKB, MECOM, CDC42, PPP3CA, RASA1, MAP4K3, MAPK1, MAP3K4, PAK2, NLK, MAPK14, FGFR2, RAF1, RELA, MAPK3, RAC2, PPP5C, MAP3K6, HSPB1, PPP3CB, AKT2, ARRB1, MAPK13, MAP2K4, STMN1, MAPK12, NFATC2, MAP3K1, MKNK1",0.531652669587843,0.289036881004724,FALSE +"H460","Input","KEGG_MELANOGENESIS",-0.34364,-1.11,0.306,6174,0.514,"GNAI3, FZD7, CTNNB1, KRAS, NRAS, PRKACB, PLCB3, MAP2K2, MAP2K1, GSK3B, DVL3, TYRP1, TCF7L2, MAPK1, RAF1, MAPK3, DCT, CREB3L1, TYR",0.51427857351842,0.289036881004724,FALSE +"H460","Input","KEGG_MELANOMA",-0.37259,-1.17,0.245,6979,0.467,"MAP2K2, CDK4, MAP2K1, PIK3CA, HGF, PIK3CB, AKT1, CDH1, MAPK1, PIK3R2, RAF1, MAPK3, AKT2",0.610833915635468,0.330683119433888,FALSE +"H460","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.47525,1.52,0.0858,353,0.333,"MGST1, CYP1B1, AKR1C3, GSTM4, AKR1C1, GSTM1, ALDH3A1",1.06651271215129,0.47755576649368,FALSE +"H460","Input","KEGG_MISMATCH_REPAIR",-0.256,-0.811,0.659,5360,0.794,"POLD3, MSH6, MSH2, PMS2, RFC4, RFC2, LIG1, RFC3, RFC1, RFC5",0.18111458540599,0.100179497572904,FALSE +"H460","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.39873,-1.29,0.175,5735,0.443,"PIK3CD, PRKAA1, STRADA, MTOR, RICTOR, AKT3, RPS6KA6, RHEB, CAB39, RPS6KA1, PIK3CA, PIK3CB, AKT1, RPS6, STK11, RPS6KB2, MAPK1, PIK3R2, MAPK3, RPS6KB1, TSC2, AKT2, EIF4EBP1",0.756961951313706,0.35359627377693,FALSE +"H460","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.37912,-1.22,0.216,6979,0.441,"MAP2K2, PTPN11, NFATC3, MAP2K1, PIK3CA, PAK1, SOS1, IFNGR1, PIK3CB, PPP3CA, NFAT5, PLCG2, MAPK1, PLCG1, SYK, PIK3R2, RAF1, MAPK3, RAC2, VAV2, MICB, PPP3CB, PTPN6, NFATC2",0.665546248849069,0.355561410532161,FALSE +"H460","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.22772,-0.728,0.796,6008,0.841,"ADRA2A, P2RX4, HTR2B, TSPO, GRIN1, NR3C1, P2RY2",0.0990869322623309,0.0752040042020878,FALSE +"H460","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.4285,-1.36,0.148,6750,0.446,"RAC1, ABL1, MAPK7, MAP2K2, PTPN11, MAGED1, YWHAB, RPS6KA1, MAP2K1, RHOA, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, ARHGDIB, GAB1, YWHAZ, IRAK4, MAPKAPK2, TRAF6, IKBKB, CDC42, PLCG2, MAPK1, PLCG1, SORT1, MAPK14, PIK3R2, RAF1, RELA, CSK, MAPK3, PRKCD, AKT2, NGFR, MAPK13, IRS1, MAPK12, MAP3K1",0.829738284605043,0.350665141287858,FALSE +"H460","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.27037,0.873,0.587,1972,0.73,"BST1, NAMPT, NT5C, ENPP1, CD38",0.231361898752386,0.136677139879544,FALSE +"H460","Input","KEGG_NITROGEN_METABOLISM",0.37242,1.2,0.216,1024,0.492,"CPS1, CA12, GLS, GLS2",0.665546248849069,0.30803489723264,FALSE +"H460","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.52591,-1.7,0.0317,7509,0.404,"TAB2, TRAF6, IKBKB, PYCARD, HSP90AA1, MAPK1, MAPK14, RELA, MAPK3, CCL13, HSP90AB1, CASP1, IL18, MAPK13, MAPK12",1.49894073778225,0.393618634889395,FALSE +"H460","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.20529,-0.669,0.885,5365,0.897,"NHEJ1, XRCC6, PRKDC, DCLRE1C",0.0530567293021746,0.0472075569559079,FALSE +"H460","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.3823,-1.25,0.184,6979,0.436,"MAP2K2, CDK4, RXRB, MAP2K1, RXRG, PIK3CA, SOS1, PIK3CB, AKT1, PLCG2, MAPK1, PLCG1, PIK3R2, RAF1, MAPK3, AKT2, TGFA",0.735182176990464,0.360513510731414,FALSE +"H460","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.3435,1.1,0.302,1143,0.582,"NOTCH3, NOTCH1, NOTCH2, ADAM17, NCSTN",0.519993057042849,0.235077015350112,FALSE +"H460","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.17053,0.545,0.969,7264,0.998,"XPA, GTF2H5, CETN2, RAD23B, POLD4, RBX1, XPC, GTF2H1, POLE3, RPA3, ERCC1, GTF2H2, DDB2, MNAT1, POLD2, CCNH, RAD23A, POLE4, RPA2, ERCC4, GTF2H3, RPA1, PCNA, DDB1, POLD1, GTF2H4, ERCC3, POLD3, ERCC2, CUL4B, ERCC5, CDK7, POLE, RFC4, RFC2, LIG1, RFC3, RFC1, CUL4A, ERCC6, RFC5",0.0136762229492347,0.000869458712628891,FALSE +"H460","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.22316,0.727,0.801,157,0.845,"TUSC3, MGAT4B",0.0963674839157623,0.0731432910503077,FALSE +"H460","Input","KEGG_OLFACTORY_TRANSDUCTION",0.33393,1.07,0.351,1601,0.605,"CAMK2D, CNGB1, CALM2",0.454692883534176,0.218244625347531,FALSE +"H460","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.34095,-1.1,0.303,6197,0.49,"MTHFD1, MTHFR, GART, SHMT1, MTHFS, DHFR, ALDH1L1",0.518557371497695,0.309803919971486,FALSE +"H460","Input","KEGG_OOCYTE_MEIOSIS",-0.37866,-1.24,0.193,6624,0.431,"PPP2R1A, PPP2CA, PRKACB, BUB1, PLK1, CUL1, SMC3, YWHAB, RPS6KA1, MAP2K1, PPP2R5C, YWHAZ, CDC23, PPP3CA, MAPK1, PPP2R5B, CDC16, BTRC, PPP2R5A, CDK1, MAPK3, PPP2R5E, PPP3CB, AURKA, PPP2R5D, FBXO5, CDK2, CCNB1, PTTG1, MAPK12",0.714442690992226,0.365522729839268,FALSE +"H460","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.5695,1.8,0.0267,2199,0.239,"AGA, HEXB, HEXA, MAN2B2, MAN2B1, GLB1, GBA, FUCA2",1.57348873863542,0.621602099051862,TRUE +"H460","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.54277,1.72,0.0341,2564,0.186,"ATP5PF, NDUFS6, ATP5PD, UQCRH, ATP5F1D, NDUFA2, TCIRG1, NDUFS8, NDUFA8, NDUFV2, UQCRFS1, PPA2, UQCRB, NDUFS4, ATP5F1B, ATP5ME, NDUFA7, COX5B, COX6B1, COX6A1, NDUFS1, UQCRC1, NDUFA5, NDUFA3, ATP6V1F, NDUFV3, SDHB, COX5A, COX17, CYC1, NDUFS3, NDUFB8, ATP5F1E, ATP5PB, SDHA, NDUFB2, UQCRC2, COX7A2, NDUFA4, COX7C, ATP5MG, NDUFV1, ATP6AP1, ATP5MC2, ATP6V1E1, UQCR10, SDHC, NDUFS5, NDUFAB1, NDUFB3, NDUFC1, ATP5F1A, ATP5PO, ATP6V0C, NDUFB6, NDUFA4L2, ATP6V1G1",1.4672456210075,0.730487055782084,TRUE +"H460","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.46817,-1.54,0.0538,8748,0.387,"GCNT3",1.26921772433361,0.412289034981089,FALSE +"H460","Input","KEGG_P53_SIGNALING_PATHWAY",-0.31637,-1.01,0.392,7624,0.561,"RRM2, CHEK1, THBS1, CDK1, APAF1, TSC2, CD82, CDK2, CCNB1",0.406713932979543,0.251037138743839,FALSE +"H460","Input","KEGG_PANCREATIC_CANCER",-0.32008,-1.04,0.369,7011,0.544,"CDK4, MAP2K1, PIK3CA, BRCA2, PIK3CB, AKT1, IKBKB, CDC42, MAPK1, PIK3R2, RAF1, RELA, MAPK3, RAC2, STAT1, AKT2, STAT3, TGFA",0.43297363384094,0.26440110030182,FALSE +"H460","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.41762,-1.35,0.14,7826,0.446,"DPYD, COASY, PANK4",0.853871964321762,0.350665141287858,FALSE +"H460","Input","KEGG_PARKINSONS_DISEASE",0.5456,1.73,0.0343,2579,0.194,"UCHL1, ATP5PF, NDUFS6, ATP5PD, UQCRH, ATP5F1D, NDUFA2, NDUFS8, SNCA, NDUFA8, NDUFV2, UQCRFS1, UQCRB, NDUFS4, ATP5F1B, NDUFA7, COX5B, COX6B1, VDAC1, COX6A1, UBE2G2, HTRA2, NDUFS1, UQCRC1, NDUFA5, NDUFA3, CYCS, NDUFV3, SDHB, COX5A, CYC1, NDUFS3, NDUFB8, ATP5F1E, ATP5PB, SDHA, NDUFB2, UQCRC2, COX7A2, NDUFA4, COX7C, NDUFV1, ATP5MC2, UQCR10, SLC25A6, SDHC, NDUFS5, NDUFAB1, NDUFB3, NDUFC1, VDAC2, ATP5F1A, ATP5PO, NDUFB6, NDUFA4L2, SLC25A31",1.46470587995723,0.712198270069774,TRUE +"H460","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.43898,-1.39,0.132,5720,0.462,"YWHAQ, TUBA3C, FYN, TUBB4B, NCK1, TUBB6, CTNNB1, ARPC1B, ABL1, HCLS1, EZR, ARPC1A, ROCK1, RHOA, ROCK2, TUBA1B, ARPC4, TUBB3, TUBB1, YWHAZ, CDH1, ARPC3, CDC42, TUBB, ARPC2, TUBB2A, WASL, CTTN, TUBA1C",0.87942606879415,0.335358024443874,FALSE +"H460","Input","KEGG_PATHWAYS_IN_CANCER",-0.23294,-0.765,0.758,6941,0.832,"LAMB3, GSTP1, MAP2K2, CDK4, CUL2, RXRB, MAP2K1, CKS1B, RHOA, RXRG, PIK3CA, STK36, BRCA2, HGF, SOS1, PTK2, TFG, PIK3CB, AKT1, GSK3B, PIAS4, ARNT, CDH1, TRAF6, IKBKB, MECOM, CDC42, DVL3, HSP90AA1, PLCG2, TCF7L2, MAPK1, DAPK1, PLCG1, RARA, LAMA3, LAMA4, PIK3R2, FGFR2, RAF1, RELA, STAT5A, MAPK3, TRAF3, RAC2, STAT1, NCOA4, HSP90AB1, AKT2, STAT5B, CDK2, STAT3, PIAS2, TGFA",0.120330794367946,0.0798766737092761,FALSE +"H460","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.28819,-0.922,0.489,6725,0.641,"RPE, UGP2, XYLB, CRYL1",0.31069114087638,0.193141970481183,FALSE +"H460","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.52521,-1.72,0.0341,6028,0.466,"RBKS, ALDOC, PFKP, RPE, PRPS2, PGLS, PFKM, RPIA, PGM2, GPI, DERA, PGM1, PFKL, FBP1",1.4672456210075,0.33161408331,FALSE +"H460","Input","KEGG_PEROXISOME",-0.21418,-0.681,0.876,7303,0.891,"EHHADH, CAT, CRAT, IDH2, PEX6, MVK, FAR1, DAO, FAR2",0.0574958938319193,0.0501222959631252,FALSE +"H460","Input","KEGG_PHENYLALANINE_METABOLISM",0.27242,0.895,0.57,1755,0.743,"ALDH3A1, GOT2, MAOA",0.244125144327509,0.129011186239425,FALSE +"H460","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.34129,-1.1,0.298,6587,0.49,"INPP4B, PIP4K2A, PIP5K1A, CDS2, PLCB3, PIK3CA, OCRL, PIK3CB, IMPA1, INPPL1, PLCG2, PLCG1, INPP1, PIK3R2, DGKA, INPP5B, PIK3C2B, SYNJ2, DGKH",0.525783735923745,0.309803919971486,FALSE +"H460","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.38312,1.23,0.193,2696,0.479,"HMOX1, ALAS1, FECH, HMOX2, HCCS, PPOX, GUSB, UGT2B17, EARS2, FTH1",0.714442690992226,0.319664486585437,FALSE +"H460","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.2417,-0.771,0.763,7109,0.83,"RXRB, DBI, CYP27A1, RXRG, EHHADH, CD36, FABP2, HMGCS2, FABP3",0.11747546204512,0.0809219076239261,FALSE +"H460","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45982,1.45,0.113,129,0.374,"AKR1D1",0.94692155651658,0.42712839779952,FALSE +"H460","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.46106,-1.48,0.0985,6546,0.417,"TAP2, UNG, ADA, DCLRE1C, PTPRC",1.00656376950239,0.379863945026242,FALSE +"H460","Input","KEGG_PRION_DISEASES",0.54598,1.76,0.0332,689,0.201,"NCAM2, NCAM1, LAMC1, C9, HSPA5, NOTCH1",1.47886191629596,0.696803942579511,TRUE +"H460","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.3699,-1.19,0.243,7138,0.465,"RPS6KA1, MAP2K1, PIK3CA, PIK3CB, AKT1, FZR1, CDC23, HSP90AA1, MAPK1, CDC16, MAPK14, PIK3R2, RAF1, CDK1, MAPK3, HSP90AB1, CCNA2, AKT2, CDK2, CCNB1, MAPK13, MAPK12",0.614393726401688,0.332547047110046,FALSE +"H460","Input","KEGG_PROPANOATE_METABOLISM",0.27859,0.892,0.556,1587,0.735,"ACSS3, MCEE, ECHS1, SUCLG1, SUCLG2, ACAT1, PCCB",0.254925208417942,0.133712660915805,FALSE +"H460","Input","KEGG_PROSTATE_CANCER",-0.44992,-1.41,0.126,6950,0.468,"GSTP1, MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, IKBKB, HSP90AA1, TCF7L2, MAPK1, PIK3R2, FGFR2, RAF1, RELA, MAPK3, HSP90AB1, CREB3L1, AKT2, CDK2, TGFA",0.899629454882437,0.329754146925876,FALSE +"H460","Input","KEGG_PROTEASOME",0.15261,0.489,0.998,6839,0.996,"PSMB9, PSMB7, PSMA5, PSMC3, PSMB6, PSMA1, PSMC4, PSMA2, PSMB3, PSMC5, PSMD14, PSMB5, PSMC1, PSMA6, PSMC2, PSMC6, PSMA3, PSMB4, PSMD4, PSMA4, POMP, PSMD7, PSMA7, PSME3, PSMB2, PSMB10, PSMB8, PSMA8, PSMD8, PSMD13, PSMD11, PSMB1, PSMF1, PSMD6, PSMD2, PSMD12, PSMD1, PSME4, SEM1, PSME1, PSMD3",0.000869458712628891,0.00174066157630127,FALSE +"H460","Input","KEGG_PROTEIN_EXPORT",0.23327,0.744,0.761,622,0.87,"HSPA5, SPCS1",0.118615343229427,0.0604807473813815,FALSE +"H460","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.27386,-0.864,0.595,8202,0.73,"MDH1, GLUD2",0.22548303427145,0.136677139879544,FALSE +"H460","Input","KEGG_PURINE_METABOLISM",0.28608,0.935,0.499,1909,0.739,"PAPSS2, PDE3B, PDE4D, PDE3A, POLR3H, NUDT9, POLR3K, POLR2H, POLR3D, GDA, POLR2C, NME4, POLR2L, POLR2D, POLR1E, AK2, NT5C, POLR2E, GUK1, POLR3GL, PRUNE1, POLR3G, POLR3C, ENPP1, POLD4, NME3, POLR2I, PFAS, PNPT1, POLR3F, POLR2F",0.30189945437661,0.131355561605174,FALSE +"H460","Input","KEGG_PYRIMIDINE_METABOLISM",0.29286,0.941,0.496,1909,0.743,"POLR3H, POLR3K, POLR2H, POLR3D, TXNRD2, POLR2C, NME4, POLR2L, UPRT, TXNRD1, POLR2D, POLR1E, DUT, NT5C, POLR2E, TYMP, POLR3GL, POLR3G, POLR3C, POLD4, NME3, POLR2I, PNPT1, POLR3F, POLR2F",0.304518323509803,0.129011186239425,FALSE +"H460","Input","KEGG_PYRUVATE_METABOLISM",-0.26043,-0.858,0.601,6912,0.732,"ACACA, ACYP1, ACSS2, GLO1, ACAT2, MDH1, PKLR, ACACB, PKM",0.22112552799726,0.135488918941608,FALSE +"H460","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.38927,-1.27,0.163,6398,0.438,"KRAS, NRAS, ARPC1B, WASF2, CRKL, FGD3, PIP4K2A, CYFIP1, PIP5K1A, ITGA2, RAC1, SLC9A1, ARHGEF1, EZR, MAP2K2, IQGAP3, ARPC1A, ARHGEF7, PAK3, ROCK1, ITGB6, MAP2K1, RHOA, PIK3CA, PAK1, SOS1, PTK2, ROCK2, PAK4, PIK3CB, RDX, VCL, ARPC4, DIAPH3, MYH10, ARPC3, PXN, CFL1, ARHGEF12, CDC42, SCIN, ITGA4, ARPC2, MAPK1, BCAR1, NCKAP1, MYH14, PAK2, MYLK, PIK3R2, FGFR2, ARHGAP35, RAF1, ITGB3, MYH9, CSK, MAPK3, RAC2, VAV2, GSN, SSH3, DIAPH1, BAIAP2, WASL, CYFIP2",0.787812395596042,0.3585258894959,FALSE +"H460","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.29623,-0.96,0.488,5747,0.607,"PRKAA1, GABARAPL2, PIK3C3, ATG12, PIK3R4, ATG7, ATG3, ATG4B",0.311580177997289,0.216811308924742,FALSE +"H460","Input","KEGG_RENAL_CELL_CARCINOMA",-0.41953,-1.36,0.124,6398,0.446,"KRAS, NRAS, CRKL, RAC1, MAP2K2, PTPN11, PAK3, CUL2, MAP2K1, PIK3CA, PAK1, HGF, SOS1, PAK4, PIK3CB, AKT1, ARNT, GAB1, CDC42, MAPK1, PAK2, PIK3R2, RAF1, MAPK3, AKT2, TGFA",0.906578314837765,0.350665141287858,FALSE +"H460","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.23037,-0.744,0.799,8024,0.849,"MME",0.0974532206860086,0.0710923097560473,FALSE +"H460","Input","KEGG_RETINOL_METABOLISM",-0.41015,-1.32,0.158,6676,0.448,"DHRS3, RDH11, ADH5, DGAT1, RDH10, ADH1C, DHRS9",0.801342913045577,0.348721986001856,FALSE +"H460","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.46756,-1.51,0.0872,8118,0.391,"ACP5, TYR",1.05948351506743,0.407823242604133,FALSE +"H460","Input","KEGG_RIBOSOME",-0.54356,-1.76,0.0351,6007,0.645,"RPL36, RPL27, RPL31, RPS26, RPL18, RPL11, RPS7, RPL3, RPS3, RPS13, RPS5, RPS9, RPL23, RPL10, RPL15, RPL26, RPL37A, RPL32, RPL18A, RPL10A, RPL7, RPS18, RPL14, RPL21, RPS15A, RPL35, RPS4X, RPS19, RPL8, RPS6, RPS2, RPL37, RPL9, RPL30, RPS24, RPS16, RPS25, RPL13A, RPL17, RPL28, RPL29, RPL19, RPL23A, RPL34, RPL27A, RPL24, RSL24D1, RPL22, RPL7A, FAU, RPS11, RPL36A, RPL36AL, RPS27L, UBA52, RPS23, RPS10, RPL38",1.45469288353418,0.190440285364732,FALSE +"H460","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.49258,-1.57,0.0744,7571,0.387,"TRAF6, IKBKB, RIPK1, MAPK14, RELA, TRAF3, IFIH1, MAPK13, ISG15, MAPK12, MAP3K1, CYLD",1.12842706445412,0.412289034981089,FALSE +"H460","Input","KEGG_RNA_DEGRADATION",0.35517,1.15,0.267,2342,0.542,"HSPA9, HSPD1, EXOSC8, LSM4, DCP2, TENT4A, EXOSC1, LSM2, EXOSC4, EXOSC10, LSM8, EXOSC6, MPHOSPH6, DCPS, LSM3, EXOSC5, DCP1A, PNPT1, PARN, EXOSC7, WDR61, EXOSC9, CNOT2, LSM6",0.573488738635425,0.266000713461613,FALSE +"H460","Input","KEGG_RNA_POLYMERASE",0.6689,2.19,0.00394,2035,0.0905,"POLR3H, POLR3K, POLR2H, POLR3D, POLR2C, POLR2L, POLR2D, POLR1E, POLR2E, POLR3GL, POLR3G, POLR3C, POLR2I, POLR3F, POLR2F, POLR2G",2.40450377817443,1.0433514207948,TRUE +"H460","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.33732,1.1,0.328,116,0.582,"PAPSS2, GGT1",0.484126156288321,0.235077015350112,FALSE +"H460","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.2783,0.885,0.576,398,0.734,"FN1, LAMB1, PIK3R3, LAMA1, LAMC1, LAMA5, ITGAV, LAMB2",0.239577516576788,0.134303940083929,FALSE +"H460","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.2615,-0.852,0.618,8342,0.735,"VAMP8, YKT6, VAMP3",0.209011524911184,0.133712660915805,FALSE +"H460","Input","KEGG_SPHINGOLIPID_METABOLISM",0.60432,1.94,0.0181,383,0.185,"GALC, PLPP3, GLA, ASAH1, ARSA",1.74232142513082,0.732828271596986,TRUE +"H460","Input","KEGG_SPLICEOSOME",0.29516,0.951,0.459,2731,0.757,"PPIE, SNRPB2, SF3B4, LSM4, SRSF1, SNU13, LSM2, SNRPD3, SNRPF, HNRNPU, SRSF8, PHF5A, TRA2A, SNRPG, SF3B5, SRSF6, SRSF7, LSM8, SRSF5, PRPF18, SRSF9, PPIH, TXNL4A, RBM8A, SRSF3, LSM3, HNRNPA3, TCERG1, SRSF2, SRSF10, ISY1, NCBP2, TRA2B, RBM25, SF3A3, HNRNPK, RBMX, SNRPA, U2SURP, DDX5, SF3A1, SRSF4, LSM6, BCAS2, PRPF40A, ALYREF, SNRPB, PRPF4, RBM17, DHX8, CHERP, SNRNP70, SNRNP40, THOC3, DDX46",0.338187314462739,0.120904120499927,FALSE +"H460","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.39267,-1.26,0.173,7080,0.432,"GYS1, PGM2, UGP2, MGAM, GPI, HK1, AGL, PGM2L1, PGM1",0.761953896871205,0.364516253185088,FALSE +"H460","Input","KEGG_STEROID_BIOSYNTHESIS",-0.62399,-2,0.0114,6129,0.55,"CEL, LIPA, CYP51A1, LSS, NSDHL, SQLE, MSMO1, HSD17B7, SOAT2, FDFT1, DHCR24, TM7SF2, DHCR7",1.94309514866353,0.259637310505756,FALSE +"H460","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.69483,2.26,0.00617,285,0.268,"CYP21A2, AKR1D1, CYP1B1, AKR1C3, AKR1C1",2.20971483596676,0.571865205971211,FALSE +"H460","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.3127,1.01,0.384,1265,0.671,"C9, SNRPD3, C7",0.415668775632469,0.173277479831008,FALSE +"H460","Input","KEGG_TASTE_TRANSDUCTION",0.53334,1.76,0.0397,2207,0.201,"CACNA1A, GNB1, GNB3, GNAS",1.40120949323689,0.696803942579511,TRUE +"H460","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.66274,-2.12,0.00795,7922,0.608,"ACAT2, MVD, HMGCS2, MVK, FDPS, HMGCS1",2.09963287134353,0.216096420727265,FALSE +"H460","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28637,0.93,0.493,536,0.718,"FST, TGFB2, TGFBR1, E2F5, THBS3, SMAD2",0.30715308072277,0.1438755557577,FALSE +"H460","Input","KEGG_THYROID_CANCER",-0.50513,-1.61,0.0475,6376,0.379,"CTNNB1, KRAS, NRAS, MAP2K2, RXRB, MAP2K1, RXRG, TFG, CDH1, TCF7L2, MAPK1, MAPK3, NCOA4",1.32330639037513,0.421360790031928,FALSE +"H460","Input","KEGG_TIGHT_JUNCTION",-0.27612,-0.891,0.544,5842,0.688,"TJP3, PPP2R2B, CSNK2A1, CSNK2A2, PPP2R2A, MYL12A, PPP2CB, GNAI3, AKT3, PARD6G, MAP3K20, LLGL2, CTNNB1, KRAS, NRAS, RAB13, PPP2R1A, PPP2CA, HCLS1, CDK4, EPB41, RHOA, TJAP1, AKT1, MYH10, PRKCQ, CDC42, F11R, MYH14, MYH7B, CLDN7, MYH3, MYH9, CGN, PRKCD, AKT2, PRKCI, CTTN, MYH11, EPB41L1, CLDN3, CRB3, CLDN18",0.26440110030182,0.162411561764489,FALSE +"H460","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.36332,-1.17,0.251,6925,0.467,"TBK1, MAP2K2, MAP2K1, PIK3CA, IRF3, PIK3CB, AKT1, TAB2, IRAK4, TRAF6, IKBKB, RIPK1, MAPK1, MAPK14, PIK3R2, RELA, MAPK3, TRAF3, STAT1, AKT2, MAPK13, MAP2K4, MAPK12",0.600326278518962,0.330683119433888,FALSE +"H460","Input","KEGG_TRYPTOPHAN_METABOLISM",0.25244,0.805,0.681,789,0.802,"CYP1B1, KYNU, ECHS1",0.166852888087215,0.0958256317158365,FALSE +"H460","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.40881,-1.28,0.172,7221,0.435,"PIK3CA, PIK3CB, HK1, IKBKB, MAPK1, PIK3R2, MAPK3, PKLR, PRKCD, PKM, IRS1",0.764471553092451,0.361510743045363,FALSE +"H460","Input","KEGG_TYROSINE_METABOLISM",-0.52107,-1.69,0.0392,6759,0.382,"COMT, MIF, GOT1, ADH5, TYRP1, ADH1C, TRMT11, METTL2B, LCMT1, ALDH1A3, DCT, TYR",1.40671393297954,0.417936637088291,FALSE +"H460","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.52938,-1.72,0.0416,6979,0.466,"MAP2K2, CDK4, PAK3, NFATC3, MAP2K1, RHOA, PIK3CA, PAK1, SOS1, PAK4, PIK3CB, AKT1, GSK3B, PRKCQ, IKBKB, CDC42, PPP3CA, NFAT5, MAPK1, PLCG1, PAK2, MAPK14, PIK3R2, RAF1, RELA, MAPK3, VAV2, PPP3CB, AKT2, PTPRC, MAPK13, PTPN6, MAPK12, NFATC2",1.38090666937326,0.33161408331,FALSE +"H460","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.30709,-1.02,0.412,5542,0.553,"FBXO4, CUL4B, HERC2, HUWE1, FBXO2, UBE2D4, HERC4, SMURF1, CBL, UBE2N, CDC34, UBE2NL, UBE2K, UBA2, ANAPC4, UBA1, UBE2Q1, TRIM32, CBLB, UBE2L3, UBE4B, UBE2D2, NEDD4L, CUL3, CUL5, CUL1, DET1, UBE2O, CUL2, ITCH, CUL4A, UBE2E1, UBA6, SYVN1, PIAS4, FZR1, TRAF6, UBE2E2, WWP1, CDC23, TRIM37, CDC16, BTRC, KEAP1, SMURF2, UBE2C, UBE2L6, MAP3K1, PIAS2",0.385102783966865,0.257274868695302,FALSE +"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.31571,1.04,0.384,1137,0.645,"PDHB, PDHA1",0.415668775632469,0.190440285364732,FALSE +"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.38241,1.21,0.212,1863,0.493,"ACAA2, HSD17B10, MCEE, HIBADH, ACADSB, ECHS1, OXCT1, ACADS, IVD, ACAT1, BCKDHB, PCCB, AUH, BCKDHA, DLD",0.673664139071249,0.30715308072277,FALSE +"H460","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.28505,-0.923,0.524,6712,0.648,"PRKACB, PLCB3, ARHGEF1, MAP2K2, ROCK1, MAP2K1, RHOA, ROCK2, PRKCQ, ARHGEF12, MAPK1, MYLK, RAF1, MAPK3, PRKCD, MYH11",0.280668713016273,0.188424994129407,FALSE +"H460","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.42696,-1.39,0.118,5663,0.462,"ARHGDIA, RAB5B, NSF, DCTN1, DYNC1LI2, RAB5A, DYNLL1, PRKACB, DYNC1LI1, RAB11A, VAMP2, DYNLL2, ARHGDIB, DYNC1H1, RAB5C, DYNC2H1, CREB3L1",0.928117992693875,0.335358024443874,FALSE +"H460","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.5541,-1.76,0.0257,6979,0.645,"MAP2K2, NFATC3, MAP2K1, PIK3CA, PTK2, PIK3CB, AKT1, MAPKAPK2, PXN, CDC42, PPP3CA, NFAT5, PLCG2, MAPK1, PLCG1, MAPK14, PIK3R2, RAF1, MAPK3, RAC2, HSPB1, PPP3CB, AKT2, MAPK13, MAPK12, NFATC2",1.59006687666871,0.190440285364732,FALSE +"H460","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.22788,0.74,0.817,2778,0.863,"TJP1, TCIRG1, PRKCB, ATP6V1F, SLC12A2, PDIA4, ACTG1, ATP6AP1, GNAS, ATP6V1E1, ACTB, ATP6V0C, ATP6V1G1, ATP6V1B2, ADCY9",0.0877779434675845,0.0639892042847904,FALSE +"H460","Input","KEGG_VIRAL_MYOCARDITIS",-0.3596,-1.16,0.248,6642,0.474,"ICAM1, RAC1, ABL1, EIF4G2, MYH10, EIF4G1, MYH14, MYH7B, MYH3, MYH9, RAC2, MYH11, ABL2",0.605548319173784,0.324221658325915,FALSE +"H460","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.26673,-0.841,0.646,5901,0.747,"CSNK2A1, CSNK2A2, MAP3K7, SMAD3, PPP2CB, CACYBP, FZD7, CSNK1E, CTNNB1, PPP2R1A, PPP2CA, PRKACB, RAC1, PLCB3, DAAM1, CUL1, ROCK1, NFATC3, RHOA, ROCK2, PPP2R5C, GSK3B, DVL3, PPP3CA, NFAT5, TCF7L2, PPP2R5B, BTRC, CSNK1A1, NLK, PPP2R5A, PPP2R5E, RAC2, PPP3CB, PPP2R5D, NFATC2",0.189767482004916,0.126679398184601,FALSE +"H520","Input","KEGG_ABC_TRANSPORTERS",-0.288,-0.863,0.62,6792,0.695,"ABCA2, ABCD1, ABCC3, ABCA12, ABCG2, ABCA1, ABCB8",0.207608310501746,0.158015195409886,FALSE +"H520","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.3015,-0.893,0.562,5328,0.671,"ARAF, RELA, AKT3, STAT3, GRB2, BRAF, STAT5A, PIK3CB, NFKB1, AKT1, PIK3R1, PML, CHUK, MAPK3, MAPK1, PIK3R3, IKBKG, SOS1, CCND1, IKBKB",0.250263684430939,0.173277479831008,FALSE +"H520","Input","KEGG_ADHERENS_JUNCTION",-0.43395,-1.33,0.148,6625,0.386,"WAS, MAPK3, NECTIN4, RHOA, MAPK1, ACTN2, PARD3, MET, ERBB2, ACTN1, CDH1, MAP3K7, EGFR, NECTIN2, RAC3, VCL, BAIAP2, PTPRJ, TGFBR2, IQGAP1, IGF1R, RAC2",0.829738284605043,0.413412695328245,FALSE +"H520","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.38133,-1.13,0.304,5343,0.471,"PRKAB1, RELA, AKT3, PRKAB2, STAT3, NFKB1, NFKBIB, AKT1, TRAF2, CHUK, TRADD, IRS2, IKBKG, ACSL4, IRS1, IKBKB, PRKCQ, RXRG",0.517126416391246,0.326979092871104,FALSE +"H520","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.37669,1.18,0.244,282,0.434,"GLUD2, ASS1, GPT2, GOT2",0.612610173661271,0.362510270487489,FALSE +"H520","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.42171,-1.27,0.184,6303,0.423,"PIK3R1, PRKCA, MAPK3, MAPK1, IRS2, PIK3R3, SLC9A3R2, NEDD4L, PRKCB, IRS1, PRKCG",0.735182176990464,0.373659632624958,FALSE +"H520","Input","KEGG_ALZHEIMERS_DISEASE",0.32205,0.991,0.434,2586,0.579,"MME, ITPR1, SDHD, ATP5MC2, NDUFA6, ATP5F1C, GRIN1, NDUFS7, ERN1, UQCRH, BAD, CASP7, ATP5PO, PSEN2, ATP5PB, ADAM10, ATP5F1B, ATP5F1E, ATP5F1A, NDUFA9, CYC1, NDUFB3, NDUFA7, NDUFA4, NDUFB7, HSD17B10, SDHC, NDUFB4, NDUFS8, NDUFS6, GSK3B, NDUFS5, NDUFC2, UQCRC2, UQCRFS1, ATP5PD, NDUFA10, CALML3, NDUFB8, NDUFV1, SDHB, NDUFS4, NDUFS3, COX4I1, ATF6, NDUFAB1, NDUFS1, PSEN1, ATP2A2, COX7C, NDUFS2, NDUFB2, NDUFV2, COX7A2L, NDUFB6, UQCRB, NDUFA3, UQCRQ, SNCA, NCSTN",0.362510270487489,0.237321436272564,FALSE +"H520","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.61161,1.99,0.0219,1050,0.235,"WARS2, RARS2, EARS2, CARS2, LARS2, NARS2, MTFMT",1.65955588515988,0.628932137728264,TRUE +"H520","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.41469,-1.23,0.21,6115,0.422,"UGP2, AMDHD2, HEXB, GNPNAT1, GFPT2, CMAS, GMPPB, GMPPA, NAGK, GFPT1, GALK1, UAP1, UGDH, NPL, PGM1, GALE",0.677780705266081,0.374687549038326,FALSE +"H520","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.24265,0.752,0.814,982,0.875,"MAP2K6, SOD1, NEFL, GRIN1, DERL1, BAD, BCL2L1",0.0893755951107988,0.0579919469776868,FALSE +"H520","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.52673,-1.6,0.0514,6404,0.496,"TAP2, HSP90AB1, TAPBP, CALR, HSPA6, HSP90AA1, PSME3, CTSL, CD74, LGMN, B2M, CTSB, HSPA2, HSPA1L, CTSS",1.28903688100472,0.304518323509803,FALSE +"H520","Input","KEGG_APOPTOSIS",-0.45471,-1.34,0.155,5725,0.403,"DFFB, PIK3CB, PRKAR2B, PPP3CB, NFKB1, PPP3CA, IRAK4, RIPK1, AKT1, PIK3R1, PRKACA, DFFA, TRAF2, CASP8, FADD, MYD88, CHUK, CASP6, TRADD, IL1RAP, BIRC2, PIK3R3, FAS, IKBKG, BID, ENDOD1, APAF1, CAPN1, TP53, CAPN2, PPP3R1, IKBKB, TNFRSF10D",0.809668301829709,0.39469495385889,FALSE +"H520","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.52063,-1.56,0.0697,7424,0.393,"PLA2G4A, CBR3, ALOX5, GGT1, EPHX2, PTGS2, PTGES",1.15676722190199,0.405607449624573,FALSE +"H520","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.43402,1.38,0.115,539,0.278,"MAOB, ALDH2, GLUD2, ASS1, GATM, MAOA, GOT2, ALDH3A2, PYCR1, SMS, CKB",0.939302159646388,0.555955204081924,FALSE +"H520","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.41071,-1.22,0.217,6698,0.406,"ITGB3, ACTN2, ACTN1, ITGB5, ITGA2B, DES, ITGB1, ITGAV, ITGA1, LMNA, GJA1, ITGA3, ITGA5, ITGB6",0.66354026615147,0.391473966422806,FALSE +"H520","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.60321,1.9,0.0178,1756,0.229,"ALDH2, ALDH3A2, ALDH7A1, ALDH9A1, ALDH1B1",1.74957999769111,0.640164517660112,TRUE +"H520","Input","KEGG_AXON_GUIDANCE",-0.47552,-1.46,0.0898,6559,0.369,"ROCK2, ABLIM1, MAPK3, ABL1, SRGAP1, RHOA, MAPK1, LIMK1, MET, ROCK1, SEMA4B, EPHA6, NRP1, ABLIM3, SRGAP2, SRGAP3, SLIT2, PLXNB2, EFNB2, CFL2, ITGB1, RAC3, EFNA5, L1CAM, EPHA2, PPP3R1, EFNB1, EPHB2, EFNA1, RAC2, NTN4, SEMA3C",1.0467236633327,0.43297363384094,FALSE +"H520","Input","KEGG_BASAL_CELL_CARCINOMA",0.48127,1.5,0.0968,1560,0.308,"FZD1, CTNNB1, TCF7L1, TCF7L2, GSK3B",1.01412464269161,0.511449283499556,FALSE +"H520","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.27489,0.864,0.589,6007,0.709,"TBPL1, GTF2H3, GTF2H4, GTF2H2, TAF9B, TAF2, TAF6L, GTF2H1, TAF12, GTF2A2, GTF2F1, GTF2I, TAF1, TAF5L, GTF2B, GTF2IRD1, TAF9, TBP, GTF2F2, TAF4, TAF7, TAF6, GTF2E2, TAF5, GTF2A1, TAF10, GTF2E1",0.229884705212898,0.149353764816933,FALSE +"H520","Input","KEGG_BASE_EXCISION_REPAIR",-0.29101,-0.863,0.616,6072,0.695,"HMGB1, XRCC1, POLD1, POLD4, POLE3, POLE2, LIG1, POLE, PCNA, PARP4",0.210419287835575,0.158015195409886,FALSE +"H520","Input","KEGG_BETA_ALANINE_METABOLISM",0.48146,1.49,0.101,2076,0.301,"ALDH2, HIBCH, ALDH3A2, MLYCD, SMS, ALDH7A1, ALDH9A1, ALDH1B1, HADHA, ECHS1",0.995678626217357,0.521433504406157,FALSE +"H520","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.40583,1.3,0.171,651,0.32,"FADS2, PECR, HSD17B12, HACD2, FADS1",0.767003889607846,0.494850021680094,FALSE +"H520","Input","KEGG_BLADDER_CANCER",-0.58201,-1.75,0.0327,6638,0.508,"TYMP, MAPK3, MAPK1, ERBB2, DAPK1, CDK4, CDH1, CCND1, EGFR, TP53, DAPK3, RPS6KA5, CDKN2A",1.48545224733971,0.294136287716081,FALSE +"H520","Input","KEGG_BUTANOATE_METABOLISM",0.29553,0.933,0.486,2076,0.64,"ALDH2, ALDH3A2, BDH1, ALDH5A1, ALDH7A1, ALDH9A1, ALDH1B1, OXCT1, HADH, HADHA, PDHA1, L2HGDH, ECHS1",0.313363730737707,0.193820026016113,FALSE +"H520","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.45009,-1.36,0.139,5683,0.386,"GRB2, PTPN6, PIK3CB, PPP3CB, NFKB1, PPP3CA, NFKBIB, AKT1, PIK3R1, NFATC2, BCL10, CHUK, MAPK3, MAPK1, CD22, PIK3R3, IKBKG, SOS1, PRKCB, VAV2, RAC3, PPP3R1, PLCG2, IKBKB, PIK3AP1, CARD11, RAC2",0.856985199745905,0.413412695328245,FALSE +"H520","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.32157,-0.952,0.458,6959,0.61,"ERBB2, PLCB3, ATP2A3, ATP2B2, ATP2B4, PLCD3, EGFR, PRKCB, ERBB4, CACNA1A, PPP3R1, PLCG2, TNNC1, ITPR3, ITPKA, ADCY9, PRKCG, ERBB3",0.339134521996131,0.214670164989233,FALSE +"H520","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.2214,-0.665,0.884,7023,0.921,"TPM1, TPM2, TPM3, TNNC1, TPM4, MYL3",0.0535477349869269,0.0357403698031511,FALSE +"H520","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.37417,-1.1,0.288,6875,0.489,"CD40, CD22, CDH15, CDH3, CLDN11, ICAM2, CDH1, CD58, ITGB1, NECTIN2, L1CAM, ITGAV, CDH5, CLDN4, ICAM1, ITGB2, CD274, SDC4, CLDN6, CD99",0.540607512240769,0.31069114087638,FALSE +"H520","Input","KEGG_CELL_CYCLE",-0.28827,-0.855,0.645,6390,0.701,"MCM4, TTK, MCM7, MCM3, YWHAZ, ABL1, PLK1, CHEK2, CDC45, MCM6, CCNA2, YWHAE, YWHAQ, CDK4, YWHAG, FZR1, YWHAH, YWHAB, PCNA, CCND1, TP53, CCNB1, TGFB1, CDKN2A",0.190440285364732,0.154281982033341,FALSE +"H520","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.34986,-1.03,0.397,5640,0.529,"STAT3, PLCB4, GRB2, BRAF, GNB2, PREX1, PIK3CB, CRK, CCL13, NFKB1, NFKBIB, AKT1, PIK3R1, PRKACA, GRK2, STAT2, DOCK2, WASL, BCAR1, ROCK2, WAS, CHUK, MAPK3, GNG4, RHOA, MAPK1, PARD3, SHC1, ROCK1, PLCB3, ARRB2, PIK3R3, IKBKG, SOS1, STAT1, PXN, CXCL5, CRKL, PRKCB, VAV2, PRKCD, IKBKB, ADCY9, GNG12, ARRB1, RAC2",0.401209493236885,0.276544327964814,FALSE +"H520","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.3625,-1.08,0.348,5683,0.505,"GRB2, BRAF, STAT5A, CTBP2, PIK3CB, CRK, NFKB1, AKT1, PIK3R1, BCR, CHUK, MAPK3, ABL1, MAPK1, SHC1, PIK3R3, IKBKG, SOS1, CDK4, CCND1, CRKL, TP53, TGFB1, TGFBR2, IKBKB, CDKN2A",0.458420756053419,0.296708621881339,FALSE +"H520","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29783,0.944,0.479,2927,0.634,"SDHD, SUCLA2, PCK2, SDHC, PDHA1, CS, SDHB, DLAT, IDH3B, SUCLG1, IDH3G, PDHB, SDHA, IDH1, IDH3A",0.319664486585437,0.197910742118267,FALSE +"H520","Input","KEGG_COLORECTAL_CANCER",-0.29811,-0.896,0.562,6266,0.673,"AKT1, PIK3R1, MSH2, MAPK3, MLH1, RHOA, MAPK1, BIRC5, PIK3R3, CCND1, TP53, RAC3, TGFB1, TGFBR2, RAC2",0.250263684430939,0.171984935776023,FALSE +"H520","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.44316,-1.33,0.142,7300,0.386,"PLG, MBL2, F8, CD59, C3, CD55, A2M, PLAU, CFB, SERPINE1, CFI, SERPINA1, TFPI",0.847711655616944,0.413412695328245,FALSE +"H520","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.22395,0.707,0.821,1687,0.874,"GOT2, DNMT3B, SMS, DNMT3A, CBS, MAT1A, APIP, MAT2A",0.0856568428805592,0.058488567365597,FALSE +"H520","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.37407,-1.11,0.294,6842,0.48,"MET, CD40, IL1RAP, TNFRSF21, FAS, IFNGR1, HGF, ACVR1, CXCL5, EGFR, IL6ST, TGFB1, TGFBR2, IL6, EPO, OSMR, LTBR, IL18, TNFRSF10D",0.531652669587843,0.318758762624413,FALSE +"H520","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.53277,-1.58,0.0568,5897,0.406,"TBK1, NFKB1, NFKBIB, TREX1, RIPK1, CHUK, IKBKG, DDX58, IRF3, IKBKB, IL6, ZBP1, IL18",1.24565166428898,0.391473966422806,FALSE +"H520","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.53114,-1.59,0.0549,7023,0.477,"TPM1, TPM2, ITGB5, ITGA2B, DES, ITGB1, TPM3, TGFB1, ITGAV, ITGA1, LMNA, TNNC1, TPM4, MYL3, ADCY9, ITGA3, ITGA5, ITGB6",1.26042765554991,0.321481620959886,FALSE +"H520","Input","KEGG_DNA_REPLICATION",-0.53333,-1.58,0.0569,4986,0.406,"POLA1, RFC5, RNASEH1, POLD2, RFC2, RFC4, POLD3, MCM5, POLA2, RPA3, PRIM1, POLD1, MCM4, MCM7, MCM3, PRIM2, POLD4, POLE3, RNASEH2A, RNASEH2C, POLE2, MCM6, LIG1, POLE, PCNA",1.24488773360493,0.391473966422806,FALSE +"H520","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.6349,-1.88,0.0176,6679,0.408,"MAPK3, MAPK1, NOTCH2, SOS1, EGFR, NOTCH3, ETV6, ETS1, ETS2",1.75448733218585,0.38933983691012,FALSE +"H520","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.57053,1.82,0.0305,204,0.205,"MAOB, ALDH3A1, GSTA4, GSTM2, GSTA5, MAOA",1.51570016065321,0.688246138944246,TRUE +"H520","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.48686,-1.42,0.122,7911,0.384,"DPYD, UPP1, TPMT, CDA",0.913640169325252,0.415668775632469,FALSE +"H520","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.4673,-1.39,0.119,6996,0.377,"HMMR, ITGB5, COL4A1, ITGA2B, ITGB1, LAMA3, LAMA4, COL6A1, ITGAV, ITGA1, LAMB3, TNC, LAMB1, COL5A2, ITGA3, SDC4, ITGA5, ITGB6",0.924453038607469,0.423658649794207,FALSE +"H520","Input","KEGG_ENDOCYTOSIS",-0.45783,-1.4,0.123,6062,0.386,"RUFY1, LDLR, STAM2, PLD2, SNF8, SMURF2, VPS36, GIT1, CHMP2A, CLTB, VPS37A, GRK2, PRKCI, SH3GLB1, CHMP4C, EHD3, RAB22A, ITCH, HGS, CHMP5, EPN3, HSPA6, PDCD6IP, ARFGAP1, ARFGAP3, RNF41, RAB11FIP4, STAM, PARD3, MET, SH3GLB2, CHMP4A, CHMP4B, ARRB2, RABEP1, DNAJC6, ARF6, EGFR, NEDD4L, ERBB4, EPS15, EPN1, DAB2, CLTA, EHD2, SH3KBP1, EHD1, PARD6B, RAB31, HSPA2, PARD6G, RAB11FIP5, ARRB1, IGF1R, ERBB3, HSPA1L",0.910094888560602,0.413412695328245,FALSE +"H520","Input","KEGG_ENDOMETRIAL_CANCER",-0.34435,-1.02,0.388,5533,0.532,"AKT3, CTNNA1, GRB2, BRAF, PIK3CB, AKT1, PIK3R1, MAPK3, MLH1, MAPK1, ERBB2, ILK, PIK3R3, SOS1, CDH1, CCND1, EGFR, TP53",0.411168274405793,0.274088367704952,FALSE +"H520","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.18133,0.567,0.975,1025,0.99,"PTPRZ1, JAM3, F11R, ATP6V0A1, ADAM10, ATP6V0A2",0.0109953843014632,0.00436480540245009,FALSE +"H520","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.40815,-1.22,0.194,5277,0.406,"NCK2, ARAF, HBEGF, AKT3, PAK2, GRB2, BRAF, STAT5A, PIK3CB, CRK, PLCG1, ABL2, CAMK2D, AREG, AKT1, PIK3R1, PRKCA, MAPK3, ABL1, MAPK1, SHC1, ERBB2, PIK3R3, SOS1, EGFR, CRKL, PRKCB, ERBB4, PLCG2, PRKCG, ERBB3",0.712198270069774,0.391473966422806,FALSE +"H520","Input","KEGG_ETHER_LIPID_METABOLISM",-0.34683,-1.05,0.364,5362,0.524,"PAFAH1B1, PLD1, PLA2G12A, LPCAT1, PAFAH1B2, PLD2, PAFAH1B3, PLPP3, PLA2G4A",0.438898616350944,0.280668713016273,FALSE +"H520","Input","KEGG_FATTY_ACID_METABOLISM",0.46753,1.48,0.0943,2076,0.268,"ACAA2, ALDH2, ECI1, ALDH3A2, ACSL5, ALDH7A1, ALDH9A1, ACOX1, CPT2, ECI2, ALDH1B1, CPT1C, HADH, HADHA, GCDH, CPT1A, ECHS1",1.02548830726267,0.571865205971211,FALSE +"H520","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.31983,-0.978,0.45,6266,0.573,"AKT1, PIK3R1, PRKCA, MAPK3, MAPK1, PIK3R3, SOS1, PLA2G4A, PRKCB, VAV2, RAC3, PLCG2, PRKCD, RAC2",0.346787486224656,0.24184537803261,FALSE +"H520","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.4002,-1.23,0.19,5775,0.422,"PIK3CB, CRK, ARPC3, CFL1, ARPC2, PLCG1, PLD2, AKT1, PIK3R1, PRKCA, DOCK2, WASL, MARCKS, WAS, MAPK3, MAPK1, PLPP3, LIMK1, PIK3R3, ARPC1B, ARPC5, PLA2G4A, CFL2, ARF6, CRKL, PRKCB, GSN, VAV2, SCIN, PLCG2, PRKCD, VASP, PRKCG, RAC2, AMPH",0.721246399047171,0.374687549038326,FALSE +"H520","Input","KEGG_FOCAL_ADHESION",-0.56261,-1.73,0.0262,6499,0.43,"BCAR1, FLT4, ROCK2, COL6A3, TLN1, MAPK3, ITGB3, DOCK1, RHOA, MAPK1, PARVB, ACTN2, MET, SHC1, ERBB2, ACTN1, ROCK1, ILK, BIRC2, PIK3R3, ARHGAP35, ITGB5, COL4A1, HGF, SOS1, CAV1, ITGA2B, PXN, CCND1, ITGB1, PPP1R12A, MYL12A, EGFR, CRKL, PRKCB, LAMA3, LAMA4, CAPN2, VAV2, RAC3, COL6A1, VCL, ITGAV, ITGA1, FLNA, LAMB3, TNC, PARVA, LAMB1, MYL9, COL5A2, FLNC, VASP, PRKCG, ITGA3, IGF1R, ZYX, CAV2, FLNB, ITGA5, RAC2, ITGB6",1.58169870868025,0.366531544420413,FALSE +"H520","Input","KEGG_FOLATE_BIOSYNTHESIS",0.47477,1.46,0.0902,75,0.272,"GGH",1.04479346245806,0.565431095965801,FALSE +"H520","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.35974,-1.07,0.344,5729,0.513,"ALDOC, AKR1B1, PMM1, PHPT1, TPI1, FBP2, MTMR1, PFKL, MTMR6, GMPPB, GMPPA, MTMR7, ALDOA, PFKFB2, PFKP",0.46344155742847,0.289882634888184,FALSE +"H520","Input","KEGG_GALACTOSE_METABOLISM",-0.41829,-1.24,0.205,7354,0.44,"GALK1, B4GALT1, PGM1, GALE, PFKP",0.688246138944246,0.356547323513813,FALSE +"H520","Input","KEGG_GAP_JUNCTION",-0.33642,-1.02,0.412,6679,0.532,"MAPK3, MAPK1, PLCB3, TUBB1, TUBB3, SOS1, EGFR, PRKCB, TUBB4B, GJA1, ITPR3, ADCY9, PRKCG, TUBA4A",0.385102783966865,0.274088367704952,FALSE +"H520","Input","KEGG_GLIOMA",-0.51035,-1.55,0.0723,5683,0.337,"GRB2, BRAF, PIK3CB, PLCG1, CAMK2D, AKT1, PIK3R1, PRKCA, MAPK3, MAPK1, SHC1, PIK3R3, SOS1, CDK4, CCND1, EGFR, PRKCB, TP53, PLCG2, CDKN2A, PRKCG, IGF1R",1.14086170270547,0.472370099128661,FALSE +"H520","Input","KEGG_GLUTATHIONE_METABOLISM",0.315,1.02,0.366,725,0.556,"GSTA4, GSTM2, GSTA5, PGD, SMS, GCLC, GSTZ1",0.436518914605589,0.254925208417942,FALSE +"H520","Input","KEGG_GLYCEROLIPID_METABOLISM",0.2907,0.897,0.52,1380,0.689,"ALDH2, AKR1A1, AGPAT4, GK, ALDH3A2, PLPP2, PLPP1, ALDH7A1, ALDH9A1, DGKE",0.283996656365201,0.161780778092374,FALSE +"H520","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.30194,-0.896,0.541,5789,0.673,"PLA2G12A, ETNK1, LPCAT1, CDS2, DGKZ, PLD2, GPAT3, LPGAT1, LYPLA2, GPAT4, MBOAT7, CDS1, PLPP3, AGPAT3, GPD2, DGKH, PCYT2, AGPAT2, PLA2G4A, GPD1L, PEMT, DGKA",0.266802734893431,0.171984935776023,FALSE +"H520","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.59227,1.82,0.0214,384,0.205,"PIPOX, MAOB, GLDC, GATM, MAOA, PHGDH, CHDH",1.66958622665081,0.688246138944246,TRUE +"H520","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.26249,-0.789,0.735,6205,0.769,"TPI1, FBP2, GAPDH, PKLR, ENO1, PFKL, LDHA, DLD, PGAM1, PGAM4, ENO2, ALDOA, ALDH1A3, LDHB, PGM1, ACSS2, PFKP, GALM, ALDH3B1",0.133712660915805,0.114073660198569,FALSE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.37979,-1.14,0.261,8200,0.469,"CHST12",0.583359492661719,0.328827157284917,FALSE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.59244,1.81,0.0446,2580,0.193,"EXT2, B3GAT3, B4GALT7, HS2ST1, XYLT2, EXT1, EXTL3, HS3ST1",1.35066514128786,0.714442690992226,TRUE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.7729,-2.3,0.00653,7363,0.0953,"ST3GAL1, B4GAT1, B3GNT2, B4GALT1",2.18508681872493,1.02090709936167,TRUE +"H520","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.18809,-0.561,0.967,5019,0.992,"HGSNAT, GLB1, HPSE, GALNS, GUSB, GNS, HEXB, IDS, SGSH",0.0145735259169983,0.00348832784582135,FALSE +"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.23468,0.712,0.804,2188,0.896,"B4GALNT1, SLC33A1, HEXA",0.0947439512515487,0.0476919903378748,FALSE +"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.64224,-1.95,0.00632,6425,0.372,"NAGA, HEXB, ST3GAL1, B3GALT5",2.19928292171761,0.429457060118102,FALSE +"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.82526,-2.43,0,7401,0.0584,"B3GNT3, B4GAT1, B3GNT2, FUT3, B4GALT1, B3GALT5",Inf,1.2335871528876,TRUE +"H520","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.45217,1.41,0.112,1925,0.282,"PIGX, PIGM, PIGA, PIGO, PGAP1, PIGQ",0.950781977329818,0.549750891680639,FALSE +"H520","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.36436,1.16,0.243,1923,0.437,"MTHFD2, GRHPR, MTHFD1L, CS",0.614393726401688,0.359518563029578,FALSE +"H520","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.28103,-0.828,0.665,6200,0.726,"PLD2, CAMK2D, PRKACA, PRKCA, MAPK3, MAPK1, PLCB3, SOS1, PLA2G4A, EGFR, PRKCB, MMP14, PRKCD, ITPR3, ADCY9",0.177178354696895,0.139063379299906,FALSE +"H520","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.36966,-1.12,0.275,7659,0.473,"LRP2, CSNK1A1",0.560667306169737,0.325138859262188,FALSE +"H520","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.4953,-1.5,0.0792,7231,0.374,"ITGA2B, CD59, CD55, CD9, ITGA1, ANPEP, IL6, CD33, ITGA3, EPO, ITGA5",1.10127481841051,0.42712839779952,FALSE +"H520","Input","KEGG_HISTIDINE_METABOLISM",0.55534,1.71,0.0353,694,0.213,"MAOB, ALDH3A1, ALDH2, MAOA, ALDH3A2, TRMT11",1.45222529461218,0.671620396561262,TRUE +"H520","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.16828,-0.502,0.989,6290,1,"RPA3, POLD1, BLM, POLD4, TOP3B",0.0048037084028206,0,FALSE +"H520","Input","KEGG_HUNTINGTONS_DISEASE",0.32765,1.03,0.371,2479,0.553,"SLC25A4, ITPR1, SOD1, SDHD, ATP5MC2, NDUFA6, TFAM, ATP5F1C, GRIN1, NDUFS7, UQCRH, VDAC1, ATP5PO, ATP5PB, ATP5F1B, ATP5F1E, VDAC3, ATP5F1A, NDUFA9, CYC1, TBPL1, NDUFB3, CREB1, NDUFA7, NDUFA4, NDUFB7, SLC25A31, SDHC, NDUFB4, NDUFS8, POLR2A, SLC25A5, NDUFS6, NDUFS5, NDUFC2, UQCRC2, SIN3A, UQCRFS1, ATP5PD, NDUFA10, NDUFB8, SLC25A6, POLR2B, NDUFV1, POLR2H, VDAC2, SDHB, NDUFS4, NDUFS3, COX4I1, SOD2, NDUFAB1, NDUFS1, HDAC2, COX7C, NDUFS2, NDUFB2, NDUFV2, COX7A2L, NDUFB6, UQCRB, POLR2K, NDUFA3",0.430626090384954,0.257274868695302,FALSE +"H520","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.56424,-1.68,0.0524,7023,0.47,"TPM1, TPM2, ITGB5, ITGA2B, DES, ITGB1, TPM3, TGFB1, ITGAV, ITGA1, LMNA, TNNC1, TPM4, IL6, MYL3, ACE, ITGA3, ITGA5, ITGB6",1.28066871301627,0.327902142064283,FALSE +"H520","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.42131,-1.28,0.163,6626,0.427,"PIP4K2C, SYNJ2, PLCB3, INPP1, PLCD3, PLCG2, ITPK1, IMPA2, ITPKA, INPP4B, ISYNA1",0.787812395596042,0.369572124974976,FALSE +"H520","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.22647,-0.687,0.882,5533,0.902,"AKT3, PRKAB2, PPP1CA, GRB2, BRAF, PIK3CB, PRKAR2B, CRK, PTPN1, EXOC7, FBP2, AKT1, PIK3R1, PRKACA, PKLR, PRKCI, MAPK3, MAPK1, TSC1, SHC1, IRS2, PIK3R3, FASN, SOS1, RHEB, CRKL, PPP1R3D, PYGB, TRIP10, IRS1, IKBKB",0.0545314148681803,0.0447934624580583,FALSE +"H520","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.74123,-2.21,0,6875,0.113,"CD40, TGFB1, IL6, LTBR",Inf,0.94692155651658,TRUE +"H520","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.4681,-1.39,0.134,5640,0.377,"STAT3, GRB2, STAT5A, PTPN6, PIK3CB, STAM2, IFNAR1, JAK1, AKT1, PIK3R1, STAT2, OSM, STAM, PIK3R3, IFNGR1, SOS1, STAT1, CCND1, IRF9, IL6ST, IL6, STAT6, EPO, OSMR",0.872895201635192,0.423658649794207,FALSE +"H520","Input","KEGG_LEISHMANIA_INFECTION",-0.49863,-1.52,0.0859,5911,0.361,"NFKB1, NFKBIB, IRAK4, JAK1, TAB1, MYD88, MAPK3, MAPK1, CYBA, IFNGR1, STAT1, TAB2, ITGB1, C3, MAP3K7, PRKCB, TGFB1, PTGS2, ITGB2",1.06600683616876,0.442492798094342,FALSE +"H520","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.54327,-1.65,0.0548,6788,0.484,"RHOA, ACTN2, ACTN1, ROCK1, CYBA, PIK3R3, ARHGAP35, CLDN11, PXN, ITGB1, MYL12A, PRKCB, VAV2, VCL, PLCG2, EZR, MYL9, CDH5, VASP, CLDN4, PRKCG, ICAM1, ITGB2, SIPA1, RAC2, CLDN6, CD99",1.26121944151563,0.315154638355588,FALSE +"H520","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.68026,2.19,0.00535,2450,0.184,"ALDH2, ALDH3A2, ALDH7A1, ALDH9A1, ALDH1B1, HADHA, ECHS1, YOD1",2.27164621797877,0.735182176990464,TRUE +"H520","Input","KEGG_LONG_TERM_DEPRESSION",-0.32741,-1.01,0.407,5660,0.534,"PLCB4, BRAF, PPP2CB, PLA2G12A, PPP2R1A, PRKCA, MAPK3, MAPK1, PLCB3, PLA2G4A, PRKCB, CACNA1A, ITPR3, PRKCG, IGF1R",0.39040559077478,0.272458742971444,FALSE +"H520","Input","KEGG_LONG_TERM_POTENTIATION",-0.34625,-1.04,0.364,5643,0.526,"PPP1CA, PLCB4, BRAF, PPP3CB, PPP3CA, RPS6KA6, RPS6KA2, CAMK2D, PRKACA, PRKCA, MAPK3, MAPK1, PLCB3, PPP1R12A, PRKCB, RPS6KA1, PPP3R1, ITPR3, PRKCG",0.438898616350944,0.279014255846261,FALSE +"H520","Input","KEGG_LYSINE_DEGRADATION",0.4799,1.5,0.108,2201,0.308,"PIPOX, ALDH2, AASS, ALDH3A2, AADAT, NSD3, NSD2, NSD1, ALDH7A1, ALDH9A1, ALDH1B1, HADH, HADHA, GCDH, ECHS1, SETD1A, DOT1L",0.96657624451305,0.511449283499556,FALSE +"H520","Input","KEGG_LYSOSOME",-0.27317,-0.814,0.68,5930,0.743,"AP3M2, CTSC, GNS, AP3M1, AP1S3, CTSZ, CLTB, NAGA, HEXB, GGA1, AP3B1, IDS, AP1S1, AP1B1, ABCA2, TPP1, FUCA1, M6PR, CTSL, NPC2, GGA3, LGMN, CTSA, PSAPL1, CTSV, SGSH, CLTA, TCIRG1, ATP6V0A4, CTSB, CTSS, CTSH, LAPTM4A",0.167491087293764,0.129011186239425,FALSE +"H520","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.42418,-1.27,0.176,5634,0.423,"PAK2, RASA2, HSPA8, GRB2, BRAF, RPS6KA4, MAP3K5, HSPA1A, PLA2G12A, CRK, DUSP3, PPP3CB, NFKB1, PPP3CA, MAP3K20, RPS6KA6, PPM1B, RPS6KA2, MAPKAPK2, SRF, AKT1, PRKACA, PRKCA, NFATC2, TAB1, TRAF2, HSPA6, CHUK, MAPK3, PPM1A, NF1, MAPK1, ARRB2, FAS, IKBKG, SOS1, PLA2G4A, TAB2, MAP3K7, STMN1, EGFR, CRKL, PRKCB, TP53, CACNA1A, TAOK3, RAC3, RPS6KA1, TGFB1, MOS, PPP3R1, MAP3K11, FLNA, TGFBR2, IKBKB, FLNC, STK4, HSPA2, GNG12, RPS6KA5, HSPB1, PRKCG, ARRB1, RRAS, HSPA1L, FLNB, RAC2",0.75448733218585,0.373659632624958,FALSE +"H520","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.2979,-0.891,0.555,6339,0.667,"PKLR, MNX1, IAPP",0.255707016877324,0.175874166083451,FALSE +"H520","Input","KEGG_MELANOGENESIS",0.22826,0.723,0.798,1560,0.91,"KITLG, FZD1, CTNNB1, TCF7L1, GNAO1, PRKACB, CREB1, TCF7L2, ADCY6, MAP2K1, GSK3B",0.0979971086492706,0.0409586076789064,FALSE +"H520","Input","KEGG_MELANOMA",-0.35006,-1.05,0.373,6679,0.524,"MAPK3, MAPK1, MET, PIK3R3, HGF, CDK4, CDH1, CCND1, EGFR, TP53, CDKN2A, IGF1R",0.428291168191312,0.280668713016273,FALSE +"H520","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.59069,1.88,0.0158,182,0.211,"ALDH3A1, AKR1C2, AKR1C1, AKR1C3, GSTA4, GSTM2, GSTA5, EPHX1",1.80134291304558,0.675717544702307,TRUE +"H520","Input","KEGG_MISMATCH_REPAIR",-0.51797,-1.55,0.0731,5079,0.337,"RFC5, POLD2, RFC2, RFC4, MSH6, POLD3, MSH3, RPA3, POLD1, MSH2, POLD4, MLH1, PMS2, LIG1, PCNA",1.13608262304214,0.472370099128661,FALSE +"H520","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.44162,-1.33,0.133,5533,0.386,"AKT3, BRAF, PIK3CB, RPS6KA6, RPS6KA2, RICTOR, CAB39, AKT1, PIK3R1, MAPK3, MAPK1, TSC1, PIK3R3, RHEB, RPS6KA1",0.876148359032914,0.413412695328245,FALSE +"H520","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.51619,-1.55,0.0734,5683,0.337,"GRB2, BRAF, PTPN6, PIK3CB, PPP3CB, PPP3CA, PLCG1, IFNAR1, PIK3R1, PRKCA, NFATC2, MAPK3, MAPK1, SHC1, PIK3R3, FAS, IFNGR1, BID, SOS1, ICAM2, RAET1L, ULBP2, PRKCB, ZAP70, VAV2, RAC3, PPP3R1, PLCG2, PRKCG, ICAM1, ITGB2, TNFRSF10D, RAC2",1.13430394008393,0.472370099128661,FALSE +"H520","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.34073,-1.03,0.385,6304,0.529,"CHRNE, NR3C1, PARD3, FPR2, TSPO, PLG, HCRTR1",0.414539270491499,0.276544327964814,FALSE +"H520","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.48462,-1.49,0.0836,5683,0.372,"GRB2, BRAF, RPS6KA4, MAP3K5, PIK3CB, CRK, NFKB1, PLCG1, RPS6KA6, NFKBIB, IRAK4, RPS6KA2, MAPKAPK2, ZNF274, NGFR, CAMK2D, AKT1, PIK3R1, YWHAZ, MAPK3, ABL1, RHOA, MAPK1, SHC1, YWHAE, YWHAQ, IRS2, PIK3R3, SOS1, ARHGDIA, YWHAG, YWHAH, YWHAB, CRKL, TP53, RPS6KA1, PLCG2, IRS1, PRKCD, IKBKB, ARHGDIB, RPS6KA5",1.07779372256098,0.429457060118102,FALSE +"H520","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.4936,-1.48,0.0876,7280,0.371,"ENPP1, NT5C2, NNMT, PNP, QPRT, NAMPT, NT5E",1.05749589383192,0.430626090384954,FALSE +"H520","Input","KEGG_NITROGEN_METABOLISM",0.41043,1.3,0.154,106,0.32,"CA8, GLUD2",0.812479279163537,0.494850021680094,FALSE +"H520","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.57708,-1.75,0.0274,5875,0.508,"CCL13, NFKB1, SUGT1, NFKBIB, TAB1, HSP90AB1, CASP8, CHUK, MAPK3, HSP90AA1, MAPK1, BIRC2, IKBKG, TAB2, MAP3K7, TAB3, IKBKB, IL6, IL18, TRIP6",1.56224943717961,0.294136287716081,FALSE +"H520","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.23537,-0.702,0.834,7371,0.889,"XRCC4",0.0788339493622613,0.0510982390297863,FALSE +"H520","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.51999,-1.57,0.0579,6266,0.399,"AKT1, PIK3R1, PRKCA, MAPK3, MAPK1, ERBB2, PIK3R3, SOS1, CDK4, CCND1, EGFR, PRKCB, TP53, PLCG2, STK4, CDKN2A, PRKCG, RXRG",1.23732143627256,0.399027104313252,FALSE +"H520","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.15114,-0.457,1,6322,0.998,"NUMB, DTX3L, NOTCH2, NUMBL, NCOR2, NOTCH3",0,0.000869458712628891,FALSE +"H520","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.24838,-0.742,0.783,5785,0.838,"POLD3, ERCC5, RBX1, RAD23A, RPA3, POLD1, POLD4, POLE3, POLE2, LIG1, POLE, PCNA, RAD23B, DDB2",0.106238237942057,0.0767559813697235,FALSE +"H520","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.5139,1.59,0.0683,1249,0.294,"MAN2A1, MAN1A1, ALG9, MGAT1, ALG3, STT3A, MAN1C1, DOLPP1, ST6GAL1, ALG5, MOGS, ALG1, GANAB, RPN2",1.16557929631847,0.531652669587843,FALSE +"H520","Input","KEGG_OLFACTORY_TRANSDUCTION",0.22785,0.72,0.817,1766,0.898,"CNGB1, PRKACB, CALML3",0.0877779434675845,0.0467236633326956,FALSE +"H520","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.44863,1.38,0.117,1173,0.278,"MTHFS, MTHFR, MTHFD2, MTFMT, MTHFD1L",0.931814138253838,0.555955204081924,FALSE +"H520","Input","KEGG_OOCYTE_MEIOSIS",-0.37421,-1.13,0.287,5628,0.471,"CDK2, PPP1CA, PPP2CB, CDC26, PPP3CB, PPP2R5A, PPP2R1A, PPP3CA, RBX1, RPS6KA6, AR, RPS6KA2, CAMK2D, PRKACA, YWHAZ, MAPK3, PLK1, AURKA, MAPK1, YWHAE, YWHAQ, YWHAG, YWHAH, STAG3, YWHAB, CCNB1, RPS6KA1, MOS, PPP3R1, ITPR3, ADCY9, IGF1R",0.542118103266008,0.326979092871104,FALSE +"H520","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.20708,0.647,0.922,317,0.94,"MANBA",0.0352690789463706,0.0268721464003014,FALSE +"H520","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.49024,1.48,0.103,2838,0.268,"SDHD, ATP5MC2, NDUFA6, ATP5F1C, NDUFS7, UQCRH, ATP6V0A1, ATP5PO, COX11, ATP5PB, ATP5MG, ATP5F1B, ATP5F1E, ATP6V0A2, ATP5F1A, NDUFA9, CYC1, NDUFB3, NDUFA7, ATP5ME, NDUFA4, NDUFB7, SDHC, NDUFB4, NDUFS8, NDUFS6, NDUFS5, NDUFC2, UQCRC2, UQCRFS1, ATP6V1B2, ATP5PD, NDUFA10, NDUFB8, ATP12A, NDUFV1, ATP6V1D, ATP6V1H, SDHB, NDUFS4, NDUFS3, COX4I1, NDUFAB1, NDUFS1, COX7C, NDUFS2, ATP6V0D1, NDUFB2, ATP6AP1, NDUFV2, COX7A2L, NDUFB6, UQCRB, NDUFA3, ATP6V1A, UQCRQ, ATP6V1E1, NDUFB10, SDHA, ATP6V1G1, NDUFB9, NDUFC1, UQCRC1",0.987162775294828,0.571865205971211,FALSE +"H520","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.36792,1.16,0.247,986,0.437,"GCNT1, GALNT10, GALNT6",0.607303046740334,0.359518563029578,FALSE +"H520","Input","KEGG_P53_SIGNALING_PATHWAY",-0.48802,-1.47,0.09,6533,0.37,"CASP8, RCHY1, CHEK2, RRM2, FAS, SERPINB5, BID, CDK4, CCND1, APAF1, TP53, CCNB1, DDB2, CD82, CDKN2A, SERPINE1",1.04575749056068,0.431798275933005,FALSE +"H520","Input","KEGG_PANCREATIC_CANCER",-0.38737,-1.18,0.236,6667,0.447,"CHUK, MAPK3, MAPK1, ERBB2, PIK3R3, IKBKG, CDK4, STAT1, CCND1, EGFR, TP53, RAC3, TGFB1, TGFBR2, IKBKB, CDKN2A, RAC2",0.627087997029893,0.349692476868064,FALSE +"H520","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.39467,-1.17,0.25,6861,0.447,"BCAT2, ENPP1, DPYD",0.602059991327962,0.349692476868064,FALSE +"H520","Input","KEGG_PARKINSONS_DISEASE",0.42956,1.38,0.141,2560,0.278,"SLC25A4, UCHL1, SDHD, ATP5MC2, NDUFA6, ATP5F1C, NDUFS7, UQCRH, VDAC1, ATP5PO, ATP5PB, ATP5F1B, ATP5F1E, VDAC3, ATP5F1A, NDUFA9, CYC1, NDUFB3, NDUFA7, NDUFA4, NDUFB7, SLC25A31, SDHC, NDUFB4, NDUFS8, SLC25A5, NDUFS6, NDUFS5, NDUFC2, UQCRC2, UQCRFS1, ATP5PD, NDUFA10, NDUFB8, SLC25A6, NDUFV1, VDAC2, SDHB, NDUFS4, NDUFS3, COX4I1, NDUFAB1, NDUFS1, COX7C, NDUFS2, NDUFB2, NDUFV2, COX7A2L, NDUFB6, UQCRB, NDUFA3, UQCRQ, SNCA",0.85078088734462,0.555955204081924,FALSE +"H520","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.34035,-1.04,0.367,5780,0.526,"TUBB, ARPC3, TUBA1C, ARPC2, OCLN, HCLS1, ACTB, PRKCA, WASL, YWHAZ, ROCK2, WAS, ABL1, RHOA, CTTN, ROCK1, YWHAQ, TUBB1, TUBB3, ARPC1B, ARPC5, CDH1, ITGB1, TUBB4B, EZR, TUBA4A",0.435333935747911,0.279014255846261,FALSE +"H520","Input","KEGG_PATHWAYS_IN_CANCER",-0.37667,-1.12,0.29,5628,0.473,"CDK2, CTNNA1, STAT3, ITGA2, GRB2, BRAF, DVL2, MITF, STAT5A, CTBP2, PIK3CB, CRK, RALBP1, NFKB1, MSH3, PLCG1, MMP2, RBX1, CUL2, AR, ELOC, ELOB, JAK1, AKT1, PIK3R1, TFG, PRKCA, MSH2, TRAF2, HSP90AB1, CASP8, PML, BCR, FADD, CHUK, MAPK3, ABL1, MLH1, HSP90AA1, RHOA, MAPK1, MET, ERBB2, BIRC5, CCDC6, NCOA4, BIRC2, PIK3R3, TRAF5, FAS, IKBKG, COL4A1, DAPK1, BID, HGF, SOS1, ITGA2B, CDK4, CKS1B, CDH1, STAT1, CCND1, ITGB1, EGFR, CRKL, PRKCB, TP53, LAMA3, LAMA4, TRAF1, RAC3, TPM3, TGFB1, ITGAV, PLCG2, TGFBR2, LAMB3, LAMB1, DAPK3, IKBKB, STK4, IL6, CDKN2A, PRKCG, RXRG, ITGA3, PTGS2, IGF1R, ETS1, RAC2",0.537602002101044,0.325138859262188,FALSE +"H520","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.40957,-1.22,0.203,5708,0.406,"GUSB, AKR1B1, UGP2, RPE, UGDH, XYLB",0.692503962086787,0.391473966422806,FALSE +"H520","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.4555,-1.37,0.141,5189,0.382,"TALDO1, TKT, H6PD, PGM2, ALDOC, RPE, FBP2, RBKS, RPIA, PFKL, G6PD, DERA, ALDOA, PGM1, PFKP",0.85078088734462,0.417936637088291,FALSE +"H520","Input","KEGG_PEROXISOME",0.30174,0.952,0.452,797,0.633,"PIPOX, PRDX1, SOD1, PECR, SLC27A2, MLYCD, PAOX, ACSL5, PEX12",0.344861565188618,0.198596289982645,FALSE +"H520","Input","KEGG_PHENYLALANINE_METABOLISM",0.73163,2.28,0.00256,282,0.238,"MAOB, ALDH3A1, MAOA, GOT2",2.59176003468815,0.623423042943488,TRUE +"H520","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.40811,-1.23,0.206,5775,0.422,"PIK3CB, OCRL, ITPKB, PLCG1, CDS2, DGKZ, PIK3R1, PRKCA, PIP4K2C, SYNJ2, CDS1, DGKH, PLCB3, PIK3R3, INPP1, PLCD3, PRKCB, PLCG2, ITPK1, IMPA2, ITPR3, ITPKA, PRKCG, INPP4B, DGKA",0.686132779630847,0.374687549038326,FALSE +"H520","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.28697,0.89,0.544,502,0.688,"UROD, FECH, EARS2",0.26440110030182,0.162411561764489,FALSE +"H520","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.2927,-0.883,0.59,6896,0.674,"SCP2, APOA1, ILK, DBI, LPL, ACSL4, SCD5, HMGCS2, FABP3, RXRG, PLTP",0.229147988357856,0.17134010346468,FALSE +"H520","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.63243,1.96,0.0105,654,0.216,"AKR1D1, CYP27A1",1.97881070093006,0.665546248849069,TRUE +"H520","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.39409,-1.19,0.241,6020,0.44,"TAP1, TAP2, ADA, CD40, IKBKG, ZAP70",0.617982957425132,0.356547323513813,FALSE +"H520","Input","KEGG_PRION_DISEASES",0.44472,1.41,0.125,217,0.282,"C9, NCAM1, SOD1",0.903089986991944,0.549750891680639,FALSE +"H520","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.38646,-1.17,0.244,5533,0.447,"AKT3, CDK2, BRAF, PIK3CB, CDC26, RPS6KA6, RPS6KA2, AKT1, PIK3R1, PRKACA, HSP90AB1, MAPK3, HSP90AA1, PLK1, MAPK1, CCNA2, PIK3R3, FZR1, CCNB1, RPS6KA1, MOS, ADCY9, IGF1R",0.612610173661271,0.349692476868064,FALSE +"H520","Input","KEGG_PROPANOATE_METABOLISM",0.46117,1.48,0.0801,1311,0.268,"ACSS3, ALDH2, HIBCH, ALDH3A2, MLYCD, SUCLA2, PCCA, PCCB, ALDH7A1, ALDH9A1",1.09636748391576,0.571865205971211,FALSE +"H520","Input","KEGG_PROSTATE_CANCER",-0.30533,-0.933,0.505,5450,0.628,"RELA, CREB5, AKT3, CDK2, GRB2, BRAF, PIK3CB, NFKB1, AR, AKT1, PIK3R1, HSP90AB1, CHUK, MAPK3, HSP90AA1, MAPK1, ERBB2, PIK3R3, IKBKG, SOS1, CCND1, EGFR, TP53, IKBKB, IGF1R",0.296708621881339,0.202040356262804,FALSE +"H520","Input","KEGG_PROTEASOME",-0.42296,-1.25,0.209,4848,0.435,"PSMC2, PSMC5, PSMC4, PSMC6, PSMC3, PSMA8, PSMD4, PSMF1, PSMB2, PSMA4, PSMB1, PSMA6, PSMA5, PSMB7, PSMA1, PSMB6, PSMB8, PSMA2, PSMA7, PSMA3, PSMB3, PSME3, PSMB9",0.679853713888946,0.361510743045363,FALSE +"H520","Input","KEGG_PROTEIN_EXPORT",0.56486,1.8,0.027,2936,0.181,"SRP14, SEC63, SRPRB, SRP9, SEC62, SRPRA, SEC11C, SPCS2, SEC61A1, SPCS3, SRP19, SEC61B, SEC11A, SRP72, OXA1L",1.56863623584101,0.742321425130815,TRUE +"H520","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.37785,1.18,0.237,1973,0.434,"GLUD2, SLC25A10, PCK2, ATP1B1, ATP1B3, ATP1A3, ATP1A1, ATP1A4",0.625251653989896,0.362510270487489,FALSE +"H520","Input","KEGG_PURINE_METABOLISM",-0.21898,-0.638,0.918,6302,0.943,"PRIM1, POLD1, PKLR, AMPD2, NME6, PRIM2, POLD4, DCK, POLE3, NME7, ADA, POLE2, PFAS, CANT1, RRM2, IMPDH2, POLE, ADSL, ENPP1, NT5C2, IMPDH1, PNP, PAPSS2, AK1, AMPD3, ADCY9, POLR2F, NT5E",0.0371573187987575,0.0254883072626717,FALSE +"H520","Input","KEGG_PYRIMIDINE_METABOLISM",-0.31055,-0.95,0.469,6302,0.606,"PRIM1, POLD1, NME6, PRIM2, POLD4, UCKL1, DCTD, DCK, POLE3, NME7, TYMP, POLE2, CANT1, RRM2, POLE, NT5C2, CMPK1, PNP, DPYD, POLR2F, NT5E, UPP1, UPRT, CDA",0.328827157284917,0.217527375833714,FALSE +"H520","Input","KEGG_PYRUVATE_METABOLISM",0.25474,0.796,0.699,1862,0.807,"ALDH2, ALDH3A2, HAGH, ME1, PCK2, GRHPR, PKM, ALDH7A1, ALDH9A1, ME3, ALDH1B1, ACYP2, PDHA1",0.155522824254319,0.0931264652779296,FALSE +"H520","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.46502,-1.41,0.109,6625,0.385,"WAS, PIP4K2C, MAPK3, ITGB3, DOCK1, RHOA, MAPK1, ACTN2, LIMK1, ACTN1, ROCK1, PIK3R3, ARHGAP35, ITGB5, ARPC1B, ENAH, SOS1, ARPC5, ITGA2B, SSH1, IQGAP2, PXN, CFL2, ITGB1, PPP1R12A, MYL12A, EGFR, CRKL, GSN, VAV2, SCIN, RAC3, VCL, ITGAV, BAIAP2, ITGA1, MOS, IQGAP3, EZR, MYH9, SSH3, MYH14, IQGAP1, PFN1, MYL9, GNG12, ITGA3, ITGB2, RRAS, ITGA5, RAC2, ITGB6",0.962573502059376,0.414539270491499,FALSE +"H520","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.27683,-0.843,0.618,5778,0.715,"ATG7, ATG12, ATG3, ATG5",0.209011524911184,0.145693958198919,FALSE +"H520","Input","KEGG_RENAL_CELL_CARCINOMA",-0.33678,-1.01,0.409,5533,0.534,"AKT3, PAK2, GRB2, BRAF, PIK3CB, CRK, RBX1, CUL2, ELOC, ELOB, AKT1, PIK3R1, MAPK3, MAPK1, MET, PIK3R3, HGF, SOS1, CRKL, TGFB1, ETS1",0.388276691992658,0.272458742971444,FALSE +"H520","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.36845,1.14,0.262,29,0.44,"MME",0.581698708680255,0.356547323513813,FALSE +"H520","Input","KEGG_RETINOL_METABOLISM",0.51088,1.58,0.0622,1421,0.283,"RDH11, ALDH1A1, PNPLA4, RETSAT, ALDH1A2",1.20620961530918,0.54821356447571,FALSE +"H520","Input","KEGG_RIBOFLAVIN_METABOLISM",0.36275,1.14,0.274,609,0.44,"RFK, MTMR2, ACP2",0.562249437179612,0.356547323513813,FALSE +"H520","Input","KEGG_RIBOSOME",0.153,0.472,0.995,3690,0.997,"RPL26L1, RPL37, RPS27A, RPL24, RSL24D1, RPS8, RPL22, RPL29, RPS6, MRPL13, RPL13, RPS15A, RPS3A, RPS7, RPS25, RPS24, RPL35A, RPL4, RPS10, RPS16, RPS13, RPL19, RPS4X, RPL6, RPL13A, RPL23, RPS23, RPL23A, RPL8, RPS9, RPL7, RPS18, RPS11, RPL34, RPL14, RPL30, RPL3, RPS2, FAU, RPL21, RPS20, RPL5",0.00217691925427455,0.00130484168834428,FALSE +"H520","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.48029,-1.45,0.092,5897,0.369,"TBK1, NFKB1, AZI2, ATG12, NFKBIB, RIPK1, ATG5, TANK, TRAF2, CASP8, FADD, CHUK, TRADD, IKBKG, DDX58, IRF3, MAP3K7, IKBKB, ISG15",1.03621217265444,0.43297363384094,FALSE +"H520","Input","KEGG_RNA_DEGRADATION",0.22064,0.708,0.852,3163,0.887,"DCPS, HSPA9, ZCCHC7, MPHOSPH6, PARN, EXOSC10, MTREX, PAPOLG, EXOSC3, HSPD1, EXOSC1, LSM3, LSM2, CNOT10, EXOSC7, EDC3, EDC4, LSM1, CNOT2, DDX6, CNOT1, LSM4, EXOSC9, CNOT7, EXOSC5, DCP2, DCP1A",0.0695604052332999,0.0520763801682736,FALSE +"H520","Input","KEGG_RNA_POLYMERASE",0.30796,0.996,0.374,3081,0.583,"POLR2A, POLR3A, POLR2B, POLR2H, POLR1C, POLR1D, POLR2K, POLR1A, POLR1E, POLR2G, POLR2E, POLR1B, POLR2D, POLR3C, POLR2C, POLR2L",0.42712839779952,0.234331445240986,FALSE +"H520","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.26488,-0.794,0.694,5914,0.768,"SEPHS1, METTL2B, AHCY, AHCYL2, CTH, PAPSS2, GGT1",0.158640529545145,0.114638779968488,FALSE +"H520","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.5242,-1.58,0.0715,7025,0.406,"BIRC2, PIK3R3, TRAF5, IKBKG, COL4A1, ITGA2B, CDK4, CKS1B, CCND1, APAF1, ITGB1, TP53, LAMA3, LAMA4, TRAF1, ITGAV, LAMB3, LAMB1, IKBKB, RXRG, ITGA3, PTGS2",1.14569395819892,0.391473966422806,FALSE +"H520","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.33357,1.05,0.359,1370,0.533,"GOSR1, SEC22B, STX5, BET1L, BNIP1, STX2, VTI1B",0.444905551421681,0.273272790973428,FALSE +"H520","Input","KEGG_SPHINGOLIPID_METABOLISM",0.33427,1.07,0.313,1892,0.517,"SGPL1, GALC, PLPP2, PLPP1, ARSA, SMPD4, DEGS1, SMPD1",0.504455662453552,0.286509456906058,FALSE +"H520","Input","KEGG_SPLICEOSOME",0.46963,1.45,0.0968,3233,0.269,"HNRNPU, RBMX, PRPF38B, PRPF38A, ALYREF, U2SURP, THOC2, DDX5, SNRPA, ACIN1, TRA2B, XAB2, HNRNPA1, SF3A2, PPIE, HNRNPM, PRPF40B, THOC1, SNRPA1, PRPF8, SNRNP200, AQR, SRSF6, RBM17, SF3B1, ZMAT2, SRSF9, CDC5L, HNRNPA3, TXNL4A, SNW1, SNRNP27, PRPF40A, CHERP, SART1, RBM22, BUD31, SRSF2, SNRPB2, SRSF4, PRPF31, SRSF1, EFTUD2, SF3B3, SRSF3, SF3B6, DDX39B, CTNNBL1, SLU7, SRSF5, SNU13, SRSF10, PRPF19, PLRG1, USP39, CDC40, MAGOHB, SNRPD1, SNRPD2, SNRNP40, SNRPD3, THOC3, EIF4A3, LSM3, LSM2, PRPF18, PUF60, SF3A3, DDX23, SMNDC1, HNRNPK, ISY1, PRPF6, DHX8, NCBP1, RBM8A, CRNKL1, DDX46, DHX15, SRSF8, SRSF7, CWC15, U2AF1, DHX16, LSM4, DHX38, PHF5A, RBM25, HNRNPC, SNRPC, PRPF3, SF3A1, TCERG1, TRA2A, SNRPE, BCAS2, U2AF2, PRPF4",1.01412464269161,0.570247719997592,FALSE +"H520","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.43117,-1.3,0.157,7280,0.409,"ENPP1, UGDH, PYGB, PGM1, SI",0.804100347590766,0.388276691992658,FALSE +"H520","Input","KEGG_STEROID_BIOSYNTHESIS",-0.36819,-1.08,0.331,4944,0.505,"CEL, LIPA, SOAT1, CYP51A1, FDFT1, NSDHL, SOAT2, LSS, DHCR24, MSMO1",0.480172006224281,0.296708621881339,FALSE +"H520","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.6384,2,0.0169,391,0.299,"AKR1C2, AKR1C1, AKR1D1, AKR1C3, HSD17B8, HSD17B12",1.77211329538633,0.52432881167557,FALSE +"H520","Input","KEGG_SULFUR_METABOLISM",-0.55996,-1.63,0.0585,7088,0.481,"SULT1A3, PAPSS2, SULT2B1, CHST12",1.23284413391782,0.317854923626168,FALSE +"H520","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.35929,1.12,0.295,357,0.456,"C9, C4A",0.530177984021837,0.341035157335565,FALSE +"H520","Input","KEGG_TASTE_TRANSDUCTION",-0.28496,-0.841,0.642,7599,0.711,"CACNA1A, ITPR3",0.192464971931147,0.148130399270234,FALSE +"H520","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.45822,-1.37,0.117,4926,0.382,"IDI1, HMGCS1, ACAT1, HMGCR, PMVK, MVK, ACAT2, PDSS2, MVD, FDPS, DHDDS, HMGCS2",0.931814138253838,0.417936637088291,FALSE +"H520","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.27686,0.855,0.607,44,0.711,"INHBE, TGFB2",0.216811308924742,0.148130399270234,FALSE +"H520","Input","KEGG_THYROID_CANCER",-0.48955,-1.43,0.1,6679,0.383,"MAPK3, MAPK1, CCDC6, NCOA4, CDH1, CCND1, TP53, TPM3, RXRG",1,0.416801226031377,FALSE +"H520","Input","KEGG_TIGHT_JUNCTION",-0.42686,-1.31,0.151,5970,0.405,"PPP2R1A, PATJ, ACTN4, MAP3K20, OCLN, HCLS1, ACTB, TJAP1, AKT1, PPP2R2A, PRKCA, MYH10, LLGL1, PRKCI, EXOC4, RHOA, ACTN2, PARD3, CTTN, ACTN1, CLDN11, EXOC3, CDK4, TJP2, MYL12A, TJP3, PRKCB, CGN, MYH11, MYH9, MYH14, MYH7B, PRKCD, MYL9, PARD6B, AMOTL1, PRKCQ, PARD6G, CLDN4, PRKCG, RRAS, CLDN6",0.821023052706831,0.392544976785331,FALSE +"H520","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.34888,-1.06,0.35,5420,0.522,"TOLLIP, RELA, AKT3, TLR9, PIK3CB, TBK1, NFKB1, IRAK4, IFNAR1, RIPK1, AKT1, PIK3R1, TAB1, CASP8, FADD, MYD88, CHUK, MAPK3, MAPK1, CD40, PIK3R3, IKBKG, STAT1, IRF3, TAB2, MAP3K7, IKBKB, IL6",0.455931955649724,0.282329496997738,FALSE +"H520","Input","KEGG_TRYPTOPHAN_METABOLISM",0.5571,1.78,0.0448,535,0.18,"MAOB, ALDH2, WARS2, MAOA, ALDH3A2, AADAT",1.34872198600186,0.744727494896694,TRUE +"H520","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.41814,-1.26,0.186,6303,0.429,"PIK3R1, PKLR, MAPK3, MAPK1, IRS2, PIK3R3, CACNA1A, IRS1, PRKCD, IKBKB",0.730487055782084,0.367542707815276,FALSE +"H520","Input","KEGG_TYROSINE_METABOLISM",0.49964,1.54,0.0982,725,0.304,"MAOB, ALDH3A1, MAOA, GOT2, TRMT11, GSTZ1",1.00788851221305,0.517126416391246,FALSE +"H520","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.41643,-1.23,0.202,5634,0.422,"PAK2, GRB2, PTPN6, PIK3CB, PPP3CB, NFKB1, PPP3CA, PLCG1, NFKBIB, AKT1, PIK3R1, NFATC2, BCL10, CHUK, MAPK3, RHOA, MAPK1, PIK3R3, IKBKG, SOS1, CDK4, MAP3K7, ZAP70, VAV2, PPP3R1, IKBKB, PRKCQ, CARD11",0.694648630553376,0.374687549038326,FALSE +"H520","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.33138,-0.983,0.452,5714,0.571,"UBE2G2, WWP1, CDC26, UBE2E2, BIRC6, FANCL, UBE2J2, UBA6, RBX1, CUL2, ELOC, UBE2Q1, FBXO2, ELOB, SMURF2, STUB1, UBE2S, UBE3C, RCHY1, PML, ITCH, UBE2M, UBE2G1, UBE2F, BRCA1, UBA1, BIRC2, UBE4B, UBE2H, FZR1, UBE2L3, NEDD4L, TRIM32, DDB2, UBOX5, UBE2E3, UBA7, UBE2C",0.344861565188618,0.243363891754152,FALSE +"H520","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.28191,0.876,0.596,2738,0.699,"LARS2, PDHA1, PDHB, BCAT1",0.224753740259764,0.155522824254319,FALSE +"H520","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.40491,1.32,0.16,2272,0.322,"ACAA2, ALDH2, HIBCH, ACAD8, ALDH3A2, MCCC1, BCKDHB, IVD, PCCA, PCCB, ALDH7A1, ALDH9A1, HSD17B10, BCKDHA, ALDH1B1, MCEE, OXCT1, HADH, HADHA, ECHS1, ALDH6A1, MCCC2, ACADSB",0.795880017344075,0.492144128304169,FALSE +"H520","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.40861,-1.22,0.211,6559,0.406,"ROCK2, MAPK3, RHOA, MAPK1, ACTA2, ROCK1, PLCB3, PPP1R12B, PLA2G4A, PPP1R12A, MYL6B, PRKCB, CALD1, MYH11, PRKCD, MYL9, ITPR3, ADCY9, PRKCQ, PRKCG, MYL6",0.675717544702307,0.391473966422806,FALSE +"H520","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.38101,-1.14,0.271,5425,0.469,"VAMP2, CREB5, RAB11A, RAB5B, DCTN4, DCTN1, DYNC1I2, AVP, PRKACA, DCTN5, DCTN2, DYNC1LI1, DCTN6, ARHGDIA, ARHGDIB, ADCY9",0.567030709125594,0.328827157284917,FALSE +"H520","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.52027,-1.55,0.0728,5775,0.337,"PIK3CB, PLA2G12A, PPP3CB, PPP3CA, PLCG1, MAPKAPK2, AKT1, PIK3R1, PRKCA, NFATC2, MAPK3, MAPK1, PIK3R3, PXN, PLA2G4A, PRKCB, RAC3, PPP3R1, PLCG2, HSPB1, PRKCG, PTGS2, RAC2",1.13786862068696,0.472370099128661,FALSE +"H520","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.38574,-1.16,0.248,7397,0.455,"TJP2, PRKCB, PLCG2, TCIRG1, ATP6V0A4, ADCY9, KDELR3, PRKCG",0.605548319173784,0.341988603342888,FALSE +"H520","Input","KEGG_VIRAL_MYOCARDITIS",-0.57258,-1.73,0.041,6409,0.43,"MYH10, DAG1, CASP8, ABL1, CD40, BID, CAV1, CCND1, CD55, RAC3, MYH11, MYH9, MYH14, MYH7B, ICAM1, ITGB2, RAC2",1.38721614328026,0.366531544420413,FALSE +"H520","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.2965,-0.9,0.542,5660,0.68,"PLCB4, DVL2, CTBP2, PPP2CB, PPP3CB, PPP2R5A, PPP2R1A, PPP3CA, RBX1, TBL1XR1, CAMK2D, PRKACA, PRKCA, NFATC2, ROCK2, RHOA, PORCN, ROCK1, PLCB3, CACYBP, CCND1, MAP3K7, PRKCB, TP53, RAC3, FOSL1, PPP3R1, PRKCG, CSNK1A1, RAC2",0.266000713461613,0.167491087293764,FALSE diff --git a/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/GSEA/GSEA_venn_diagram.pdf 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+
+
+ + + + diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_mean_results.csv b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..4668488 --- /dev/null +++ b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"retinoid receptor agonist",0.92605,1.09193924426128,1.66400152023328e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H1650, HCC44",0.000153457917977069 +"AP inhibitor",0.5873,1.08658620894694,0.0438754357167872,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.1102480208072 +"benzodiazepine receptor agonist",0.4223,0.895357740911713,0.865382426366316,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"PPAR receptor agonist",0.38665,1.15610977784164,0.0530154216941511,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.12223000001707 +"bacterial DNA gyrase inhibitor",0.35545,1.2284457220835,0.012649125448034,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC4006",0.0415394694008123 +"calcium channel blocker",0.29445,1.0616762057188,0.402547831280457,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.604470685832317 +"mTOR inhibitor",0.26405,1.02621355502952,0.592236071461401,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.80695747500506 +"thymidylate synthase inhibitor",0.2137,1.43089953672874,7.39328678363733e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H1650, H1975",0.000122703989735374 +"adrenergic receptor antagonist",0.19995,0.892149118701577,0.977749368256249,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"adenosine receptor antagonist",0.18895,1.29351233286087,0.00190836375351865,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H1650",0.00791970957710239 +"RAF inhibitor",0.1679,1.23716347471056,0.0130123639086882,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC2279",0.0415394694008123 +"CC chemokine receptor antagonist",0.1142,1.05000965409096,0.566913414297166,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.797522260790928 +"glutamate receptor antagonist",0.10475,0.770982891133813,0.999978974219987,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"DNA methyltransferase inhibitor",0.086,1.29129469912952,0.00358354270471327,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC15",0.0123930851871334 +"FGFR inhibitor",0.02035,1.33518231654746,0.000302255460173701,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC2279",0.00179194308531551 +"glycogen synthase kinase inhibitor",0.00310000000000001,0.987101386570002,0.810811589422749,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"DNA inhibitor",-0.00239999999999997,0.800987114687082,0.99984380739688,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"VEGFR inhibitor",-0.01115,1.00782753719912,0.808224861401723,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"cytochrome P450 inhibitor",-0.01675,1.06010162745197,0.640402283544856,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.857312734422952 +"phosphatase inhibitor",-0.0243,0.896128990949993,0.993894468034018,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"ATPase inhibitor",-0.0527,1.12959480858357,0.268011224251416,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.427787146401299 +"ALK tyrosine kinase receptor inhibitor",-0.0541,1.0203735074652,0.766561794889117,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.978840445781488 +"PI3K inhibitor",-0.1006,0.790835427686577,0.999900114130944,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"protein synthesis inhibitor",-0.10245,0.860060247277694,0.997930617016542,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"sodium channel blocker",-0.1224,0.953706972541191,0.937628741184561,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"TGF beta receptor inhibitor",-0.12615,1.38715696660472,1.01999320054934e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H358, H3255",0.000122703989735374 +"EGFR inhibitor",-0.13285,0.801937408963279,0.999775733491809,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"potassium channel blocker",-0.1357,1.07544923783408,0.487287581057094,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.697325331512739 +"progesterone receptor agonist",-0.1384,1.28912334145096,0.0292190473696394,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC4006",0.0757869041150023 +"HCV inhibitor",-0.1441,1.15067270484887,0.129682874394435,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.244629058516775 +"HMGCR inhibitor",-0.14745,1.46506617328545,4.79148424610221e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H1650, HCC4006, HCC2279, H520",0.000397693192426484 +"adrenergic receptor agonist",-0.1578,1.03727261807614,0.670118751083818,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.882854862538999 +"topoisomerase inhibitor",-0.1712,1.16045384043894,0.118133051059189,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"HCC95, H520",0.228024261346806 +"MET inhibitor",-0.1739,1.48528363054263,1.33838081003218e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H2126, CALU3, H520, A549",0.000138857009040839 +"acetylcholine receptor antagonist",-0.17865,1.1797608265639,0.0666301937506903,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H358, H1703",0.149467731927224 +"phosphodiesterase inhibitor",-0.1988,0.883495545516427,0.988362896984305,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"RET tyrosine kinase inhibitor",-0.21205,1.32006014516086,0.00189976072233017,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H520",0.00791970957710239 +"sterol demethylase inhibitor",-0.22645,1.33126997044571,0.000467871198965814,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC4006",0.00258888730094417 +"bacterial 50S ribosomal subunit inhibitor",-0.2339,1.26490515142649,0.00258517790325817,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.00975317118047402 +"src inhibitor",-0.2649,1.29879745594875,0.000806675370735804,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.00393847386888658 +"estrogen receptor antagonist",-0.2942,1.19480148538311,0.0881483331885304,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.187597734734565 +"ribonucleotide reductase inhibitor",-0.2995,1.14715540634902,0.0763237338277799,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.166707102834361 +"KIT inhibitor",-0.3422,1.08505205308074,0.173851148824212,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.307013730902332 +"DNA polymerase inhibitor",-0.34505,1.08193853677943,0.208523400702626,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.353213107312612 +"vitamin D receptor agonist",-0.35875,1.23239868271509,0.0160218853261817,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"H1650, H460, H1703",0.0462166081139457 +"histamine receptor antagonist",-0.3755,0.781867837802191,0.996651950634769,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"tyrosine kinase inhibitor",-0.37635,0.900661352036731,0.906593074797396,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"PDGFR tyrosine kinase receptor inhibitor",-0.3846,1.02518180159218,0.40783564345313,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.604470685832317 +"androgen receptor antagonist",-0.3849,1.18804256967855,0.0194859168743378,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.0539110366856679 +"PLK inhibitor",-0.4099,1.39722996261211,5.35147324679525e-07,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"H1650, HCC95, H460",1.11043069871001e-05 +"proteasome inhibitor",-0.41495,1.34652400353847,9.32231298331748e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H520",0.000703410888741228 +"dopamine receptor antagonist",-0.4209,0.82659764921285,0.977937351304792,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"tubulin polymerization inhibitor",-0.45795,0.998904582925453,0.255897843969672,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.416461197048682 +"cyclooxygenase inhibitor",-0.46155,0.660057371908326,0.999957068199221,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"MEK inhibitor",-0.46725,0.96932406590203,0.453345566109778,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.660134771703712 +"estrogen receptor agonist",-0.4684,1.03259980529474,0.201524433681871,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.348469333241568 +"Bcr.Abl kinase inhibitor",-0.4745,1.24931772959231,0.00072339100870527,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"HCC95, H520",0.00375259085765859 +"protein tyrosine kinase inhibitor",-0.47895,1.11704461933217,0.165875716007256,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H3255",0.29929748757831 +"Abl kinase inhibitor",-0.48905,1.23017702940845,0.0011063036417712,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC95",0.00510128901483389 +"acetylcholine receptor agonist",-0.49585,1.11711099552184,0.0283991624643543,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0757869041150023 +"p38 MAPK inhibitor",-0.4965,1.17283504919983,0.0022750778486948,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.00899197435436515 +"opioid receptor agonist",-0.4968,1.0426688226298,0.10860869227471,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.225363036470024 +"serotonin receptor antagonist",-0.5256,1.08338987490775,0.0451618398487325,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.1102480208072 +"NFkB pathway inhibitor",-0.53025,0.90854677920292,0.593065132232634,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.80695747500506 +"AKT inhibitor",-0.53965,0.829082071678641,0.735555867265182,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.953924015359532 +"PARP inhibitor",-0.54135,1.014687988082,0.238398411035668,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.395741362319209 +"serotonin receptor agonist",-0.5635,1.49163024556144,2.29946023290837e-10,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,7,"H358, HCC95, H3255, CALU3, H520, H460, A549",1.90855199331395e-08 +"DNA alkylating agent",-0.5669,0.802604962802866,0.88683858507367,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"microtubule inhibitor",-0.57405,0.93031033164095,0.345100923634254,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.53896982885512 +"growth factor receptor inhibitor",-0.575,1.28822807722366,1.03485292547906e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.000122703989735374 +"FLT3 inhibitor",-0.58495,0.937653143982919,0.35065506937562,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.53896982885512 +"BCL inhibitor",-0.6024,1.00186932649344,0.147089944369024,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.271299230725089 +"glucocorticoid receptor agonist",-0.6055,1.00542494289205,0.11547532464001,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC15",0.228024261346806 +"DNA synthesis inhibitor",-0.64945,0.645959300901421,0.964979638325481,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987 +"MDM inhibitor",-0.65675,1.45625228710008,3.64817985908291e-08,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,5,"H1650, H2009, H520, HCC15, HCC44",1.00932976101294e-06 +"CDK inhibitor",-0.66765,1.09091107626414,0.00276128426312658,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.00996463451476114 +"antioxidant",-0.69835,1.00875036163823,0.0135194104586792,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.0415596691877917 +"bromodomain inhibitor",-0.7544,1.39203684161773,4.89720072932298e-09,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,6,"H358, H1650, HCC78, H520, H460, H1299",2.03233830266904e-07 +"CHK inhibitor",-0.77925,1.16100500361586,0.000123902359897899,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"HCC95, H2126, H520",0.000856991322627132 +"JAK inhibitor",-0.8013,0.915665883674998,0.0161479715096919,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0462166081139457 +"HSP inhibitor",-0.823,0.785202622190436,0.116334408777091,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.228024261346806 +"Aurora kinase inhibitor",-1.0024,0.772281881998508,0.000191877185647698,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"HCC95, HCC44",0.00122506203144299 +"HDAC inhibitor",-1.02295,0.562461832623241,0.0467652297387959,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.110900401952002 diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_results.csv b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_results.csv new file mode 100644 index 0000000..f466683 --- /dev/null +++ b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_results.csv @@ -0,0 +1,1661 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"H358","Pearson.est","EGFR inhibitor",-0.42175,-1,0.458,853,0.836,"canertinib, dovitinib, BMS.690514, XL.647, erlotinib, pelitinib, FERb.033, dacomitinib, CP.724714, icotinib, gefitinib, OSI.420, AEE788, lapatinib, ARRY.334543, AST.1306, afatinib, PD.153035, WZ8040, salvianolic.acid.B, BMS.599626, rociletinib, tucatinib, CUDC.101, osimertinib, neratinib",0.339134521996131,0.0777937225609836,FALSE +"H358","Pearson.est","Abl kinase inhibitor",-0.44458,-1.07,0.385,996,0.78,"nilotinib, tozasertib, flumatinib, KW.2449, imatinib, bosutinib",0.414539270491499,0.10790539730952,FALSE +"H358","Pearson.est","acetylcholine receptor agonist",-0.62096,-1.47,0.058,941,0.3,"nefiracetam, xanomeline, oxiracetam, pilocarpine",1.23657200643706,0.522878745280338,FALSE +"H358","Pearson.est","acetylcholine receptor antagonist",-0.72832,-1.74,0.00879,1341,0.133,"methscopolamine, dicycloverine",2.05601112492623,0.876148359032914,TRUE +"H358","Pearson.est","adenosine receptor antagonist",-0.58015,-1.37,0.119,836,0.371,"MRS.1220, SCH.58261, CGS.15943, sulmazole, theophylline, istradefylline, PSB.1115",0.924453038607469,0.430626090384954,FALSE +"H358","Pearson.est","adrenergic receptor agonist",-0.54518,-1.31,0.153,1267,0.416,"oxymetazoline, isoetharine, midodrine, isoxsuprine, clenbuterol",0.815308569182401,0.380906669373257,FALSE +"H358","Pearson.est","adrenergic receptor antagonist",-0.31353,-0.733,0.82,1063,0.96,"imiloxan, atenolol......, idazoxan, dronedarone, atenolol...., levobunolol",0.0861861476162833,0.0177287669604316,FALSE +"H358","Pearson.est","AKT inhibitor",-0.53644,-1.28,0.166,1182,0.442,"palomid.529, uprosertib, AT7867, CCT128930",0.779891911959945,0.354577730650908,FALSE +"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.34633,-0.811,0.702,833,0.932,"NVP.TAE684, SB.505124, CEP.37440, alectinib, GW.788388, AZD3463, DMH1",0.153662887870195,0.0305840876460186,FALSE +"H358","Pearson.est","androgen receptor antagonist",-0.68979,-1.64,0.0222,1258,0.161,"bicalutamide, flutamide",1.65364702554936,0.79317412396815,TRUE +"H358","Pearson.est","antioxidant",-0.76543,-1.84,0.00375,1386,0.0842,"benfotiamine, taurine",2.42596873227228,1.07468790850035,TRUE +"H358","Pearson.est","AP inhibitor",0.37134,1.06,0.378,49,0.709,"birinapant",0.422508200162775,0.149353764816933,FALSE +"H358","Pearson.est","ATPase inhibitor",-0.24889,-0.596,0.931,1262,0.974,"ouabain, digoxin",0.0310503190186574,0.0114410431213845,FALSE +"H358","Pearson.est","Aurora kinase inhibitor",-0.41916,-1.01,0.45,900,0.834,"PHA.680632, CCT137690, PF.03814735, SNS.314, ZM.447439, tozasertib, ENMD.2076, MK.8745, danusertib, AT.9283, hesperadin, KW.2449, barasertib, alisertib",0.346787486224656,0.0788339493622613,FALSE +"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.57727,-1.37,0.109,1036,0.371,"tilmicosin, tedizolid, josamycin, dirithromycin, azalomycin.b",0.962573502059376,0.430626090384954,FALSE +"H358","Pearson.est","bacterial DNA gyrase inhibitor",0.53988,1.57,0.0765,278,0.296,"lomefloxacin, novobiocin, sparfloxacin, norfloxacin, finafloxacin, nadifloxacin",1.11633856484638,0.528708288941061,FALSE +"H358","Pearson.est","BCL inhibitor",-0.37531,-0.9,0.599,864,0.886,"navitoclax, TW.37, venetoclax",0.222573177610689,0.0525662781129492,FALSE +"H358","Pearson.est","Bcr.Abl kinase inhibitor",-0.4618,-1.09,0.361,687,0.753,"bafetinib, metatinib, GZD824, ponatinib, nilotinib, tozasertib, flumatinib, imatinib, bosutinib",0.442492798094342,0.123205023799299,FALSE +"H358","Pearson.est","benzodiazepine receptor agonist",-0.29994,-0.715,0.819,777,0.966,"eprinomectin, CGS.20625, ZK.93423, temazepam, nefiracetam, lorazepam, piperazine",0.0867160982395816,0.0150228735845067,FALSE +"H358","Pearson.est","bromodomain inhibitor",-0.80459,-1.91,0,1283,0.115,"bromosporine, OTX015, I.BET.762, I.BET151, JQ1....",Inf,0.939302159646388,TRUE +"H358","Pearson.est","calcium channel blocker",-0.3515,-0.848,0.672,1103,0.889,"mibefradil, tetrandrine, SKF.96365",0.172630726946175,0.0510982390297863,FALSE +"H358","Pearson.est","CC chemokine receptor antagonist",0.2949,0.865,0.668,19,1,"ZK811752",0.175223537524454,0,FALSE +"H358","Pearson.est","CDK inhibitor",-0.70134,-1.68,0.0164,1213,0.153,"aminopurvalanol.a, arcyriaflavin.a, JNJ.7706621, dinaciclib, abemaciclib, P276.00, R547, PHA.848125, kenpaullone, palbociclib, PHA.793887, TG.02, indisulam, AZD5438, ribociclib, AT.7519, BMS.387032",1.7851561519523,0.815308569182401,TRUE +"H358","Pearson.est","CHK inhibitor",0.22276,0.665,0.883,1127,1,"SCH.900776, CHIR.124, AZD7762, LY2603618, LY2606368, PF.477736, SB.218078",0.0540392964224314,0,FALSE +"H358","Pearson.est","cyclooxygenase inhibitor",-0.25853,-0.621,0.905,992,0.969,"FR.122047, suxibuzone, meloxicam, piroxicam, aspirin, tryptanthrin, ketoprofen, phenazone",0.0433514207947967,0.0136762229492347,FALSE +"H358","Pearson.est","cytochrome P450 inhibitor",-0.37365,-0.882,0.623,1191,0.848,"PF.4981517, morin",0.20551195334083,0.0716041477432862,FALSE +"H358","Pearson.est","DNA alkylating agent",-0.36552,-0.891,0.599,1085,0.884,"cisplatin, streptozotocin, temozolomide, TH.302, estramustine",0.222573177610689,0.0535477349869269,FALSE +"H358","Pearson.est","DNA inhibitor",-0.26063,-0.626,0.907,1286,0.98,"pibenzimol, primaquine",0.0423927129399047,0.00877392430750515,FALSE +"H358","Pearson.est","DNA methyltransferase inhibitor",-0.40659,-0.987,0.503,774,0.803,"decitabine, fdcyd, RG108, SGI.1027, azacitidine",0.298432014944073,0.095284454721319,FALSE +"H358","Pearson.est","DNA polymerase inhibitor",-0.58302,-1.41,0.0861,1199,0.332,"trifluridine, menadione, idoxuridine",1.06499684854635,0.478861916295964,FALSE +"H358","Pearson.est","DNA synthesis inhibitor",0.25244,0.738,0.776,1086,1,"altretamine, artesunate, CB.10.277, nelarabine, cyclocytidine, floxuridine, mitomycin.c, anisomycin, azodicarbonamide, estramustine.phosphate, enocitabine, capecitabine, artemisinin, cisplatin",0.110138278741812,0,FALSE +"H358","Pearson.est","dopamine receptor antagonist",-0.26209,-0.627,0.904,869,0.994,"amisulpride, isofloxythepin, nemonapride, acetophenazine, mesoridazine, piperacetazine, lurasidone, UH.232...., sertindole, paliperidone, ziprasidone",0.0438315695246367,0.00261361560268669,FALSE +"H358","Pearson.est","estrogen receptor agonist",-0.64711,-1.56,0.0369,1327,0.182,"estradiol, PPT",1.43297363384094,0.739928612014925,TRUE +"H358","Pearson.est","estrogen receptor antagonist",-0.78659,-1.9,0,1395,0.0642,"tamoxifen, clomifene",Inf,1.19246497193115,TRUE +"H358","Pearson.est","FGFR inhibitor",-0.49966,-1.19,0.249,867,0.619,"dovitinib, regorafenib, MK.2461, orantinib, lucitanib, nintedanib, PD.173074",0.603800652904264,0.208309350979882,FALSE +"H358","Pearson.est","FLT3 inhibitor",-0.46608,-1.12,0.313,844,0.747,"ponatinib, lestaurtinib, dovitinib, sunitinib, tozasertib, ENMD.2076, sorafenib, gilteritinib, KW.2449, tandutinib, TG.02, pacritinib",0.504455662453552,0.126679398184601,FALSE +"H358","Pearson.est","glucocorticoid receptor agonist",-0.22492,-0.533,0.959,913,0.996,"fluocinolone.acetonide, halcinonide, prednisolone, prednisolone.hemisuccinate, methylprednisolone, difluprednate, halobetasol.propionate, betamethasone, flumethasone",0.0181813928293364,0.00174066157630127,FALSE +"H358","Pearson.est","glutamate receptor antagonist",0.23572,0.662,0.877,56,1,"SIB.1757, MTPG",0.0570004066339595,0,FALSE +"H358","Pearson.est","glycogen synthase kinase inhibitor",-0.28496,-0.67,0.88,998,1,"indirubin, CHIR.99021, kenpaullone",0.0555173278498314,0,FALSE +"H358","Pearson.est","growth factor receptor inhibitor",-0.58987,-1.42,0.101,850,0.351,"lestaurtinib, GSK1904529A, GW.441756, AZD3463, GSK1838705A, danusertib, PHA.848125",0.995678626217357,0.454692883534176,FALSE +"H358","Pearson.est","HCV inhibitor",-0.67676,-1.62,0.0174,1169,0.138,"narlaprevir, daclatasvir, mericitabine",1.7594507517174,0.860120913598763,TRUE +"H358","Pearson.est","HDAC inhibitor",-0.33364,-0.788,0.726,1031,0.952,"RGFP966, resminostat, dacinostat, belinostat, vorinostat, pyroxamide, M.344, RG2833, R306465",0.139063379299906,0.0213630516155257,FALSE +"H358","Pearson.est","histamine receptor antagonist",-0.42032,-0.99,0.478,848,0.816,"pheniramine, lafutidine, ICI.162846, cimetidine, nizatidine, levocetirizine, astemizole, terfenadine, tiotidine, ebastine",0.320572103387881,0.0883098412461389,FALSE +"H358","Pearson.est","HMGCR inhibitor",0.42857,1.18,0.294,830,0.689,"mevastatin, simvastatin, atorvastatin, fluvastatin, lovastatin, pitavastatin",0.531652669587843,0.161780778092374,FALSE +"H358","Pearson.est","HSP inhibitor",-0.56906,-1.35,0.123,961,0.391,"ganetespib, BIIB021, PU.H71, NMS.E973, tanespimycin, NVP.AUY922, KW.2478, alvespimycin, SNX.5422, XL888",0.910094888560602,0.407823242604133,FALSE +"H358","Pearson.est","JAK inhibitor",-0.54802,-1.31,0.145,965,0.416,"PRT062070, baricitinib, tozasertib, CEP.33779, AZD1480, atiprimod, AT.9283, AZ960, filgotinib, TG.101209, TG.02, pacritinib",0.838631997765025,0.380906669373257,FALSE +"H358","Pearson.est","KIT inhibitor",-0.55078,-1.32,0.148,879,0.433,"motesanib, pazopanib, sunitinib, regorafenib, telatinib, vatalanib, sorafenib, imatinib, tandutinib, OSI.930, masitinib",0.829738284605043,0.363512103646635,FALSE +"H358","Pearson.est","MDM inhibitor",-0.30837,-0.741,0.783,1170,0.967,"nutlin.3, CGM097",0.106238237942057,0.0145735259169983,FALSE +"H358","Pearson.est","MEK inhibitor",0.19659,0.551,0.951,264,1,"U.0126, PD.318088, Ro.4987655, MEK162, MEK1.2.inhibitor, TAK.733, AZD8330",0.0218194830625861,0,FALSE +"H358","Pearson.est","MET inhibitor",-0.39136,-0.945,0.542,1035,0.852,"INC.280, AMG458, PHA.665752",0.266000713461613,0.0695604052332999,FALSE +"H358","Pearson.est","microtubule inhibitor",-0.5927,-1.41,0.0893,1354,0.332,"secnidazole, cytochalasin.b, D.64131",1.04914854111145,0.478861916295964,FALSE +"H358","Pearson.est","mTOR inhibitor",0.18662,0.541,0.986,1183,0.969,"SB.2343, sirolimus, WAY.600, torin.1, PP242, PF.05212384, deforolimus, PKI.179, ku.0063794, PF.04691502, XL388, temsirolimus, GSK2126458, LY3023414, AZD2014, GDC.0980, everolimus, PI.103, voxtalisib, MLN0128, NVP.BEZ235, OSI.027, LY303511, WYE.354, AZD8055, WYE.125132, torin.2, palomid.529",0.0061230850587888,0.0136762229492347,FALSE +"H358","Pearson.est","NFkB pathway inhibitor",-0.45847,-1.1,0.328,1320,0.751,"IKK.2.inhibitor.V, bortezomib, betulinic.acid",0.484126156288321,0.124360062995832,FALSE +"H358","Pearson.est","opioid receptor agonist",-0.68806,-1.64,0.0249,1402,0.161,"salvinorin.a, trimebutine",1.60380065290426,0.79317412396815,TRUE +"H358","Pearson.est","p38 MAPK inhibitor",-0.65522,-1.58,0.0309,1203,0.171,"skepinone.l, VX.702, SB.239063",1.51004152057517,0.767003889607846,TRUE +"H358","Pearson.est","PARP inhibitor",-0.54165,-1.28,0.175,851,0.442,"talazoparib, AZD2461, niraparib, AG.14361, endo.IWR.1, PJ.34",0.756961951313706,0.354577730650908,FALSE +"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49175,-1.18,0.255,844,0.622,"ponatinib, dovitinib, motesanib, pazopanib, sunitinib, regorafenib, telatinib, trapidil, orantinib, vatalanib, nintedanib, sorafenib, imatinib, tandutinib, masitinib, crenolanib, CP.673451",0.593459819566045,0.206209615309181,FALSE +"H358","Pearson.est","phosphatase inhibitor",-0.37221,-0.908,0.583,1176,0.908,"GSK2830371, CID.5458317, menadione",0.234331445240986,0.0419141514789149,FALSE +"H358","Pearson.est","phosphodiesterase inhibitor",-0.37579,-0.902,0.608,755,0.901,"avanafil, YM.976, papaverine, trequinsin, EMD.53998, cilostamide, GSK256066",0.216096420727265,0.045275209020937,FALSE +"H358","Pearson.est","PI3K inhibitor",-0.20655,-0.494,0.975,636,0.981,"PI3K.IN.2, buparlisib, GSK2126458, ZSTK.474, pilaralisib, LY3023414, CUDC.907, GDC.0980, PI.103, voxtalisib, NVP.BEZ235, taselisib, LY303511, TG100.115, YM.201636, CH5132799, PIK.75, TG.100713",0.0109953843014632,0.0083309926200515,FALSE +"H358","Pearson.est","PLK inhibitor",-0.43156,-1.03,0.421,1013,0.81,"volasertib, rigosertib, NMS.1286937",0.375717904164332,0.0915149811213502,FALSE +"H358","Pearson.est","potassium channel blocker",-0.4089,-0.99,0.471,976,0.816,"oleoylethanolamide, ML133, mepivacaine",0.326979092871104,0.0883098412461389,FALSE +"H358","Pearson.est","PPAR receptor agonist",0.37717,1.11,0.308,1,0.713,"pterostilbene",0.511449283499556,0.146910470148134,FALSE +"H358","Pearson.est","progesterone receptor agonist",-0.20492,-0.494,0.985,1069,0.981,"dienogest, nomegestrol.acetate",0.00656376950238827,0.0083309926200515,FALSE +"H358","Pearson.est","proteasome inhibitor",-0.44479,-1.06,0.4,920,0.781,"MG.132, oprozomib, ixazomib.citrate, carfilzomib, bortezomib",0.397940008672038,0.1073489661227,FALSE +"H358","Pearson.est","protein synthesis inhibitor",0.2668,0.79,0.721,207,1,"clofoctol, brefeldin.a, clindamycin.phosphate, chloramphenicol.palmitate, mercaptopurine, emetine",0.142064735280571,0,FALSE +"H358","Pearson.est","protein tyrosine kinase inhibitor",-0.43403,-1.03,0.434,625,0.81,"rheochrysidin, PP.121, NVP.TAE226, tyrphostin.A9, mubritinib, CP.724714, BMS.599626, AV.412",0.362510270487489,0.0915149811213502,FALSE +"H358","Pearson.est","RAF inhibitor",-0.5932,-1.44,0.0759,940,0.334,"regorafenib, PLX.4720, AZ.628, GDC.0879, RAF265, TAK.632, sorafenib, dabrafenib",1.11975822410452,0.476253533188435,FALSE +"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.40923,-0.974,0.521,921,0.812,"sunitinib, regorafenib, sorafenib",0.283162276700476,0.0904439707588247,FALSE +"H358","Pearson.est","retinoid receptor agonist",0.58811,1.71,0.0421,254,0.531,"adapalene, LE.135, AM.580, CD.437, fenretinide",1.37571790416433,0.274905478918531,FALSE +"H358","Pearson.est","ribonucleotide reductase inhibitor",-0.28042,-0.668,0.868,974,0.987,"clofarabine, pentostatin, fludarabine.phosphate, fludarabine",0.0614802748235081,0.00568284733036327,FALSE +"H358","Pearson.est","serotonin receptor agonist",-0.67443,-1.63,0.0253,1078,0.154,"pardoprunox, zolmitriptan, ipsapirone, aripiprazole",1.59687947882418,0.812479279163537,TRUE +"H358","Pearson.est","serotonin receptor antagonist",-0.68252,-1.62,0.0185,1096,0.138,"lurasidone, sertindole, paliperidone, ziprasidone, SB.228357, SB.216641, RS.16566, aripiprazole",1.73282827159699,0.860120913598763,TRUE +"H358","Pearson.est","sodium channel blocker",-0.32599,-0.78,0.748,987,0.946,"mepivacaine, ajmaline, triamterene, lappaconite, butamben, quinidine",0.126098402135539,0.0241088635982073,FALSE +"H358","Pearson.est","src inhibitor",-0.7071,-1.69,0.00866,1216,0.167,"PP.2, TG.100572, saracatinib, masitinib, bosutinib, PP.1",2.06248210798265,0.777283528852417,TRUE +"H358","Pearson.est","sterol demethylase inhibitor",0.42524,1.21,0.194,178,0.783,"lanoconazole, terconazole",0.712198270069774,0.106238237942057,FALSE +"H358","Pearson.est","TGF beta receptor inhibitor",-0.75479,-1.8,0.0037,1290,0.096,"LY2109761, SB.431542, D.4476",2.431798275933,1.01772876696043,TRUE +"H358","Pearson.est","thymidylate synthase inhibitor",-0.37319,-0.886,0.615,868,0.858,"raltitrexed, capecitabine, carmofur, trifluridine",0.211124884224583,0.0665127121512946,FALSE +"H358","Pearson.est","topoisomerase inhibitor",0.56014,1.66,0.045,126,0.315,"epirubicin, TAS.103, beta.lapachone, nemorubicin, doxorubicin, exatecan.mesylate, voreloxin, camptothecin, mitoxantrone, rubitecan",1.34678748622466,0.501689446210399,FALSE +"H358","Pearson.est","tubulin polymerization inhibitor",-0.31829,-0.757,0.784,1046,0.962,"ABT.751, nocodazole, docetaxel, parbendazole, fosbretabulin, vinorelbine, combretastatin.A.4, paclitaxel, albendazole",0.105683937315562,0.0168249279621871,FALSE +"H358","Pearson.est","tyrosine kinase inhibitor",-0.37244,-0.889,0.61,687,0.87,"bafetinib, NVP.TAE226, apatinib, tyrphostin.A9, UNC2250, AMG.208, sunitinib, regorafenib, mubritinib, CP.724714, aminopurvalanol.a, sorafenib, BMS.599626, AV.412, tivantinib",0.214670164989233,0.0604807473813815,FALSE +"H358","Pearson.est","VEGFR inhibitor",-0.45784,-1.11,0.324,867,0.749,"dovitinib, motesanib, BMS.690514, XL.647, pazopanib, sunitinib, regorafenib, MK.2461, telatinib, ENMD.2076, AEE788, tivozanib, orantinib, vatalanib, lucitanib, nintedanib, RAF265, sorafenib, TG.100572, OSI.930, PD.173074, foretinib, golvatinib",0.489454989793388,0.125518182300534,FALSE +"H358","Pearson.est","vitamin D receptor agonist",-0.26314,-0.636,0.903,1007,1,"tacalcitol, alfacalcidol",0.0443122496864942,0,FALSE +"H1650","Pearson.est","EGFR inhibitor",-0.2229,-0.599,0.907,1101,1,"rociletinib, vandetanib, PD.168393, WZ8040, gefitinib, tyrphostin.AG.1478, icotinib, brigatinib, ARRY.334543, WZ.4002, tyrphostin.AG.494, CNX.2006, BIBX.1382, CGP.52411",0.0423927129399047,0,FALSE +"H1650","Pearson.est","Abl kinase inhibitor",-0.23747,-0.64,0.882,341,1,"flumatinib, KW.2449, ZM.306416, metatinib, ponatinib, bafetinib, bosutinib, tozasertib, dasatinib, nilotinib, GZD824, imatinib",0.0545314148681803,0,FALSE +"H1650","Pearson.est","acetylcholine receptor agonist",0.40807,1.04,0.383,320,0.727,"pilocarpine, xanomeline, nefiracetam",0.416801226031377,0.138465589140962,FALSE +"H1650","Pearson.est","acetylcholine receptor antagonist",0.53125,1.37,0.157,19,0.964,"dicycloverine",0.804100347590766,0.0159229660971692,FALSE +"H1650","Pearson.est","adenosine receptor antagonist",0.68678,1.77,0.0106,191,0.169,"PSB.1115, SCH.58261, theophylline",1.97469413473523,0.772113295386326,TRUE +"H1650","Pearson.est","adrenergic receptor agonist",0.56493,1.5,0.0886,258,0.652,"clenbuterol, A61603, metaraminol, terbutaline, methyldopa, midodrine, buphenine",1.05256627811295,0.18575240426808,FALSE +"H1650","Pearson.est","adrenergic receptor antagonist",0.47274,1.22,0.226,200,0.802,"atenolol...., atenolol......, levobunolol, carvedilol, dronedarone, oxprenolol",0.645891560852599,0.0958256317158365,FALSE +"H1650","Pearson.est","AKT inhibitor",-0.33646,-0.901,0.546,1391,1,"triciribine, ONC201",0.262807357295263,0,FALSE +"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.27869,0.704,0.794,92,1,"CEP.37440, DMH1",0.100179497572904,0,FALSE +"H1650","Pearson.est","androgen receptor antagonist",0.40748,1.02,0.439,25,0.685,"cyproterone.acetate",0.357535479757879,0.164309428507574,FALSE +"H1650","Pearson.est","antioxidant",0.35173,0.9,0.553,23,0.779,"taurine",0.257274868695302,0.108462542327436,FALSE +"H1650","Pearson.est","AP inhibitor",-0.34018,-0.908,0.569,1323,1,"birinapant",0.244887733604929,0,FALSE +"H1650","Pearson.est","ATPase inhibitor",-0.40193,-1.07,0.363,1310,0.861,"digitoxigenin, oligomycin.a, k.strophanthidin",0.440093374963888,0.0649968485463452,FALSE +"H1650","Pearson.est","Aurora kinase inhibitor",-0.17814,-0.483,0.977,379,0.983,"KW.2449, SNS.314, ZM.447439, danusertib, MK.8745, alisertib, PHA.680632, CCT137690, PF.03814735, hesperadin, AMG900, CCT129202, GSK1070916, ENMD.2076, AT.9283, tozasertib, barasertib, aurora.a.inhibitor.i, MK.5108, TAK.901, MLN.8054, CYC116",0.0101054362812269,0.00744648216786438,FALSE +"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.47257,1.21,0.232,190,0.724,"azithromycin, dirithromycin, josamycin",0.6345120151091,0.140261433802853,FALSE +"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.4375,1.1,0.335,273,0.806,"sparfloxacin, trovafloxacin, sarafloxacin",0.474955192963155,0.0936649581949093,FALSE +"H1650","Pearson.est","BCL inhibitor",-0.44463,-1.21,0.228,1082,0.785,"venetoclax, gossypol, HA14.1, obatoclax",0.642065152999546,0.105130343254747,FALSE +"H1650","Pearson.est","Bcr.Abl kinase inhibitor",-0.33975,-0.899,0.546,1026,1,"dasatinib, nilotinib, GZD824, imatinib",0.262807357295263,0,FALSE +"H1650","Pearson.est","benzodiazepine receptor agonist",0.3913,1.01,0.445,389,0.679,"piperazine, temazepam, gamma.aminobutyric.acid, nefiracetam, indiplon, CL.218872, ZK.93423",0.351639989019068,0.168130225719498,FALSE +"H1650","Pearson.est","bromodomain inhibitor",0.76843,1.99,0.00538,268,0.0651,"I.BET.762, I.BET151, JQ1...., PFI.1, bromosporine",2.26921772433361,1.18641901143181,TRUE +"H1650","Pearson.est","calcium channel blocker",0.26941,0.687,0.829,418,1,"SKF.96365, penfluridol, fendiline, efonidipine.monoethanolate, mibefradil",0.0814454694497265,0,FALSE +"H1650","Pearson.est","CC chemokine receptor antagonist",-0.22447,-0.588,0.935,1148,0.981,"ZK811752, navarixin",0.0291883891274822,0.0083309926200515,FALSE +"H1650","Pearson.est","CDK inhibitor",0.25692,0.656,0.855,515,0.991,"P276.00, JNJ.7706621, dinaciclib, AZD5438, AT.7519, aminopurvalanol.a, alvocidib, BMS.387032, PHA.793887",0.0680338852718274,0.00392634551472468,FALSE +"H1650","Pearson.est","CHK inhibitor",-0.54508,-1.43,0.142,1252,0.603,"LY2603618, CHIR.124, SCH.900776",0.847711655616944,0.219682687859849,FALSE +"H1650","Pearson.est","cyclooxygenase inhibitor",-0.24088,-0.648,0.856,1191,1,"AM.404, meloxicam, acetylsalicylsalicylic.acid, pterostilbene, tepoxalin, curcumin, FR.122047",0.0675262353228468,0,FALSE +"H1650","Pearson.est","cytochrome P450 inhibitor",0.40554,1.04,0.391,29,0.727,"morin",0.407823242604133,0.138465589140962,FALSE +"H1650","Pearson.est","DNA alkylating agent",0.38856,0.981,0.459,262,0.705,"estramustine, carmustine, ifosfamide, melphalan, mitomycin.c",0.338187314462739,0.151810883008601,FALSE +"H1650","Pearson.est","DNA inhibitor",0.22987,0.583,0.932,322,0.993,"carmustine, bendamustine, melphalan, primaquine",0.0305840876460186,0.00305075150461883,FALSE +"H1650","Pearson.est","DNA methyltransferase inhibitor",0.48665,1.23,0.229,154,0.838,"fdcyd, SGI.1027",0.640164517660112,0.0767559813697235,FALSE +"H1650","Pearson.est","DNA polymerase inhibitor",0.48552,1.25,0.215,63,0.928,"trifluridine",0.667561540084395,0.0324520237811379,FALSE +"H1650","Pearson.est","DNA synthesis inhibitor",-0.39825,-1.07,0.36,1305,0.861,"estramustine.phosphate, CB.10.277, altretamine, artesunate",0.443697499232713,0.0649968485463452,FALSE +"H1650","Pearson.est","dopamine receptor antagonist",0.28715,0.739,0.787,293,0.978,"isofloxythepin, lurasidone, sertindole, paliperidone, acetophenazine, amisulpride, ziprasidone",0.104025267640935,0.00966114521239857,FALSE +"H1650","Pearson.est","estrogen receptor agonist",0.30558,0.788,0.698,461,0.948,"estradiol, levonorgestrel, erteberel, ethinyl.estradiol",0.156144577376839,0.0231916626619338,FALSE +"H1650","Pearson.est","estrogen receptor antagonist",0.41106,1.05,0.384,403,0.801,"clomifene, toremifene, tamoxifen",0.415668775632469,0.0963674839157623,FALSE +"H1650","Pearson.est","FGFR inhibitor",-0.25052,-0.663,0.86,1434,1,"AZD4547",0.0655015487564323,0,FALSE +"H1650","Pearson.est","FLT3 inhibitor",-0.28693,-0.782,0.706,1102,1,"quizartinib, pacritinib, sunitinib, GTP.14564, midostaurin, lestaurtinib, tyrphostin.AG.1296",0.151195298948196,0,FALSE +"H1650","Pearson.est","glucocorticoid receptor agonist",-0.46503,-1.22,0.239,1056,0.838,"beclomethasone.dipropionate, prednisolone, clobetasol.propionate, triamcinolone, prednisolone.acetate, flumethasone.pivalate, halcinonide, rimexolone, desonide, ciclesonide, dexamethasone.acetate, fluocinolone.acetonide, triamcinolone.acetonide, hydrocortisone",0.621602099051862,0.0767559813697235,FALSE +"H1650","Pearson.est","glutamate receptor antagonist",-0.22013,-0.587,0.925,1161,0.953,"CGP.37849, tiletamine, latrepirdine, SIB.1757",0.0338582672609674,0.0209070993616736,FALSE +"H1650","Pearson.est","glycogen synthase kinase inhibitor",-0.26623,-0.712,0.771,876,1,"CHIR.98014, AZD2858, tideglusib, GSK.3.inhibitor.IX, indirubin, TWS.119",0.112945621949043,0,FALSE +"H1650","Pearson.est","growth factor receptor inhibitor",0.41979,1.08,0.365,413,0.81,"GSK1838705A, GW.441756, GSK1904529A, danusertib",0.437707135543525,0.0915149811213502,FALSE +"H1650","Pearson.est","HCV inhibitor",-0.58746,-1.59,0.0662,1318,0.582,"PSI.7976, narlaprevir",1.1791420105603,0.235077015350112,FALSE +"H1650","Pearson.est","HDAC inhibitor",-0.23103,-0.617,0.897,1369,1,"JNJ.26481585, romidepsin, ACY.1215",0.0472075569559079,0,FALSE +"H1650","Pearson.est","histamine receptor antagonist",0.39227,1.02,0.415,472,0.685,"cimetidine, cyproheptadine, pheniramine, zolantidine, ranitidine, tiotidine, ebastine, terfenadine",0.381951903287907,0.164309428507574,FALSE +"H1650","Pearson.est","HMGCR inhibitor",-0.80444,-2.08,0,1160,0.0937,"fluvastatin, mevastatin, atorvastatin, pitavastatin, lovastatin, simvastatin",Inf,1.02826040911222,TRUE +"H1650","Pearson.est","HSP inhibitor",-0.25155,-0.675,0.862,1143,1,"guanidine, NVP.AUY922, ganetespib, BIIB021",0.0644927341752872,0,FALSE +"H1650","Pearson.est","JAK inhibitor",0.18985,0.485,0.978,176,1,"AZD1480, WHI.P154",0.00966114521239857,0,FALSE +"H1650","Pearson.est","KIT inhibitor",-0.25269,-0.663,0.848,1186,1,"masitinib, sunitinib, lenvatinib, midostaurin, imatinib",0.0716041477432862,0,FALSE +"H1650","Pearson.est","MDM inhibitor",-0.75345,-1.97,0.00948,1235,0.127,"CGM097, AMG.232, idasanutlin, RITA",2.02319166266193,0.896196279044043,TRUE +"H1650","Pearson.est","MEK inhibitor",-0.39159,-1.04,0.391,989,0.877,"AS.703026, selumetinib, U.0126, PD.0325901, Ro.4987655, PD.198306, PD.184352, MEK162, AZD8330, TAK.733, PD.318088, refametinib",0.407823242604133,0.0570004066339595,FALSE +"H1650","Pearson.est","MET inhibitor",0.47869,1.24,0.239,206,0.879,"AMG458, INC.280, PHA.665752",0.621602099051862,0.0560111249262281,FALSE +"H1650","Pearson.est","microtubule inhibitor",-0.22285,-0.597,0.924,1093,1,"cabazitaxel, secnidazole, colchicine, estramustine.phosphate",0.0343280287798933,0,FALSE +"H1650","Pearson.est","mTOR inhibitor",-0.52921,-1.4,0.137,1111,0.588,"GDC.0980, OSI.027, MLN0128, WAY.600, WYE.354, XL388, NVP.BEZ235, deforolimus, GSK2126458, PKI.179, PP242, PF.05212384, torin.1, sirolimus, SB.2343",0.863279432843593,0.230622673923862,FALSE +"H1650","Pearson.est","NFkB pathway inhibitor",-0.28794,-0.802,0.644,1085,1,"tyloxapol, parthenolide...., BAY.11.7085, EVP4593, curcumin",0.191114132640188,0,FALSE +"H1650","Pearson.est","opioid receptor agonist",-0.26491,-0.697,0.804,382,1,"trimebutine, ADL5859, spiradoline, salvinorin.a, cebranopadol, BW.180C",0.0947439512515487,0,FALSE +"H1650","Pearson.est","p38 MAPK inhibitor",0.47436,1.21,0.246,305,0.724,"SB.239063, SB.242235, talmapimod",0.609064892896621,0.140261433802853,FALSE +"H1650","Pearson.est","PARP inhibitor",0.40416,1.03,0.431,373,0.718,"olaparib, talazoparib, PJ.34",0.365522729839268,0.1438755557577,FALSE +"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30102,-0.803,0.678,1186,1,"masitinib, sunitinib, lenvatinib, axitinib, imatinib, linifanib",0.168770306132937,0,FALSE +"H1650","Pearson.est","phosphatase inhibitor",0.35205,0.901,0.582,289,0.801,"AS.1949490, GSK2830371, mycophenolate.mofetil, mycophenolic.acid",0.235077015350112,0.0963674839157623,FALSE +"H1650","Pearson.est","phosphodiesterase inhibitor",0.46814,1.2,0.237,324,0.703,"cilostamide, zardaverine, trequinsin, YM.976, papaverine, avanafil",0.625251653989896,0.153044674980176,FALSE +"H1650","Pearson.est","PI3K inhibitor",-0.45061,-1.2,0.252,1247,0.685,"CUDC.907, pilaralisib, NVP.BEZ235, GSK2126458, PKI.179, YM.201636, PF.05212384, GDC.0941, SB.2343",0.598599459218456,0.164309428507574,FALSE +"H1650","Pearson.est","PLK inhibitor",0.77018,1.99,0.00532,167,0.0651,"volasertib, GW.843682X, BI.2536, NMS.1286937",2.27408836770495,1.18641901143181,TRUE +"H1650","Pearson.est","potassium channel blocker",0.35506,0.906,0.567,936,0.817,"dofetilide, ML133, ibutilide, oleoylethanolamide, mepivacaine, meglitinide",0.246416941107093,0.0877779434675845,FALSE +"H1650","Pearson.est","PPAR receptor agonist",-0.54729,-1.45,0.105,1272,0.655,"pterostilbene, clofibrate",0.978810700930062,0.183758700008217,FALSE +"H1650","Pearson.est","progesterone receptor agonist",-0.32815,-0.865,0.621,1239,1,"norethindrone, norgestrel, tanaproget",0.20690839982342,0,FALSE +"H1650","Pearson.est","proteasome inhibitor",0.49375,1.27,0.2,737,0.957,"bortezomib, MG.132, delanzomib, ONX.0914, ixazomib, carfilzomib, oprozomib, ixazomib.citrate",0.698970004336019,0.0190880622231565,FALSE +"H1650","Pearson.est","protein synthesis inhibitor",0.26045,0.657,0.867,211,1,"puromycin, azomycin..2.nitroimidazole., anguidine, tedizolid.phosphate",0.0619809025237897,0,FALSE +"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.43434,1.12,0.313,555,0.845,"CP.724714, AV.412, BMS.599626, PP.121, NVP.TAE226",0.504455662453552,0.0731432910503077,FALSE +"H1650","Pearson.est","RAF inhibitor",0.4941,1.27,0.213,422,0.957,"GDC.0879, dabrafenib, vemurafenib, PLX.4720, sorafenib, RAF265, TAK.632",0.671620396561262,0.0190880622231565,FALSE +"H1650","Pearson.est","RET tyrosine kinase inhibitor",-0.47084,-1.28,0.184,1108,0.776,"vandetanib, cabozantinib, sunitinib, apatinib",0.735182176990464,0.110138278741812,FALSE +"H1650","Pearson.est","retinoid receptor agonist",0.71853,1.85,0.0119,33,0.108,"adarotene, tamibarotene, AM.580",1.92445303860747,0.96657624451305,TRUE +"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.41244,1.04,0.385,182,0.727,"fludarabine, pentostatin",0.414539270491499,0.138465589140962,FALSE +"H1650","Pearson.est","serotonin receptor agonist",-0.4531,-1.2,0.244,1446,0.685,"aripiprazole",0.612610173661271,0.164309428507574,FALSE +"H1650","Pearson.est","serotonin receptor antagonist",0.50834,1.3,0.204,344,1,"lurasidone, sertindole, pirenperone, paliperidone, SB.216641, RS.16566, lerisetron, ziprasidone, SB.228357, SB.200646",0.690369832574101,0,FALSE +"H1650","Pearson.est","sodium channel blocker",0.42871,1.11,0.334,84,0.825,"butamben, lappaconite",0.476253533188435,0.0835460514500749,FALSE +"H1650","Pearson.est","src inhibitor",0.4206,1.06,0.392,277,0.816,"TG.100572, PP.1, PP.2",0.406713932979543,0.0883098412461389,FALSE +"H1650","Pearson.est","sterol demethylase inhibitor",-0.59326,-1.58,0.0692,1033,0.486,"terconazole, sulconazole, lanoconazole, ketoconazole",1.15989390554324,0.313363730737707,FALSE +"H1650","Pearson.est","TGF beta receptor inhibitor",0.24429,0.617,0.921,385,1,"LY2109761, D.4476",0.0357403698031511,0,FALSE +"H1650","Pearson.est","thymidylate synthase inhibitor",0.74562,1.93,0.00534,98,0.0739,"trifluridine, raltitrexed, doxifluridine",2.27245874297144,1.13135556160517,TRUE +"H1650","Pearson.est","topoisomerase inhibitor",0.29485,0.763,0.74,193,0.965,"exatecan.mesylate, genz.644282, etoposide.phosphate, dexrazoxane, topotecan, licochalcone.a",0.130768280269024,0.0154726866562074,FALSE +"H1650","Pearson.est","tubulin polymerization inhibitor",0.15885,0.404,0.997,992,0.997,"albendazole, parbendazole, fenbendazole, paclitaxel, nocodazole, taltobulin, vinorelbine, flubendazole, ABT.751, CYT.997, dolastatin.10, combretastatin.A.4, docetaxel, oxibendazole, fosbretabulin, vincristine, indibulin, vindesine, KX2.391, mebendazole, podophyllotoxin, epothilone.b, BNC105, vinblastine, verubulin",0.00130484168834428,0.00130484168834428,FALSE +"H1650","Pearson.est","tyrosine kinase inhibitor",0.23946,0.599,0.925,97,1,"tivantinib, hypericin, CP.724714",0.0338582672609674,0,FALSE +"H1650","Pearson.est","VEGFR inhibitor",0.1687,0.427,0.997,269,1,"lucitanib, TG.100572, foretinib, golvatinib, PD.173074, pazopanib, OSI.930",0.00130484168834428,0,FALSE +"H1650","Pearson.est","vitamin D receptor agonist",-0.70191,-1.85,0.0145,1170,0.202,"tacalcitol, alfacalcidol, doxercalciferol, paricalcitol, calcitriol",1.83863199776503,0.694648630553376,TRUE +"HCC95","Pearson.est","EGFR inhibitor",0.20896,0.565,0.973,422,1,"CUDC.101, AST.1306, AZD8931, BMS.690514, dovitinib, gefitinib, XL.647, ARRY.334543, poziotinib, dacomitinib, tyrphostin.AG.494, WZ.3146, BIBX.1382, BIBU.1361, tucatinib",0.0118871597316481,0,FALSE +"HCC95","Pearson.est","Abl kinase inhibitor",-0.68685,-1.65,0.0264,1028,0.196,"GZD824, flumatinib, KW.2449, bosutinib, ponatinib, metatinib, nilotinib, imatinib, tozasertib",1.57839607313017,0.707743928643524,TRUE +"HCC95","Pearson.est","acetylcholine receptor agonist",-0.44279,-1.09,0.345,1389,0.743,"nicotine",0.462180904926726,0.129011186239425,FALSE +"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.29163,-0.717,0.814,1012,0.906,"dicycloverine, iododexetimide",0.0893755951107988,0.0428718023231869,FALSE +"HCC95","Pearson.est","adenosine receptor antagonist",0.36837,0.999,0.423,168,0.878,"SCH.58261, PSB.1115",0.373659632624958,0.0565054840938974,FALSE +"HCC95","Pearson.est","adrenergic receptor agonist",-0.31359,-0.763,0.761,1386,0.897,"epinephrine, terbutaline",0.118615343229427,0.0472075569559079,FALSE +"HCC95","Pearson.est","adrenergic receptor antagonist",0.5372,1.42,0.12,108,1,"propranolol, prazosin, practolol, levobunolol, atenolol......, atenolol....",0.920818753952375,0,FALSE +"HCC95","Pearson.est","AKT inhibitor",-0.37586,-0.91,0.541,825,0.832,"MK.2206, A.674563, AT7867, GSK2110183, triciribine, AZD5363",0.266802734893431,0.0798766737092761,FALSE +"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.25605,-0.607,0.914,1225,0.952,"alectinib, AZD3463, AP26113",0.0390538042661686,0.0213630516155257,FALSE +"HCC95","Pearson.est","androgen receptor antagonist",0.58495,1.58,0.0831,164,0.914,"enzalutamide, bicalutamide",1.08039897621589,0.0390538042661686,FALSE +"HCC95","Pearson.est","antioxidant",-0.4151,-0.999,0.471,882,0.777,"mesna, trolox, rutin, chlorogenic.acid",0.326979092871104,0.109578981199086,FALSE +"HCC95","Pearson.est","AP inhibitor",-0.31367,-0.769,0.724,1065,0.908,"idronoxil, LCL.161",0.140261433802853,0.0419141514789149,FALSE +"HCC95","Pearson.est","ATPase inhibitor",0.42206,1.14,0.322,71,0.701,"k.strophanthidin, evodiamine",0.492144128304169,0.154281982033341,FALSE +"HCC95","Pearson.est","Aurora kinase inhibitor",-0.7399,-1.79,0.00714,1163,0.175,"SNS.314, KW.2449, GSK1070916, alisertib, PF.03814735, MLN.8054, MK.5108, TAK.901, MK.8745, AT.9283, AMG900, tozasertib, hesperadin, CYC116",2.14630178822383,0.756961951313706,TRUE +"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.26562,0.724,0.794,159,0.969,"josamycin, azithromycin",0.100179497572904,0.0136762229492347,FALSE +"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.5136,1.34,0.155,358,0.702,"finafloxacin, trovafloxacin, norfloxacin, nadifloxacin, sparfloxacin",0.809668301829709,0.153662887870195,FALSE +"HCC95","Pearson.est","BCL inhibitor",-0.48092,-1.17,0.277,946,0.653,"venetoclax, obatoclax, HA14.1, ABT.737, TW.37, gossypol",0.557520230935551,0.185086818724926,FALSE +"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.68918,-1.67,0.027,1028,0.224,"GZD824, flumatinib, bosutinib, ponatinib, metatinib, nilotinib, imatinib, tozasertib",1.56863623584101,0.649751981665837,TRUE +"HCC95","Pearson.est","benzodiazepine receptor agonist",0.45644,1.23,0.22,280,0.653,"eprinomectin, gamma.aminobutyric.acid, ZK.93423, CL.218872, piperazine, indiplon, bentazepam",0.657577319177794,0.185086818724926,FALSE +"HCC95","Pearson.est","bromodomain inhibitor",-0.61288,-1.49,0.068,1096,0.417,"PFI.1, bromosporine, OTX015",1.16749108729376,0.379863945026242,FALSE +"HCC95","Pearson.est","calcium channel blocker",0.40972,1.11,0.3,142,0.703,"SKF.96365, efonidipine.monoethanolate",0.522878745280338,0.153044674980176,FALSE +"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.28266,-0.674,0.866,1354,0.902,"navarixin",0.0624821079826534,0.0447934624580583,FALSE +"HCC95","Pearson.est","CDK inhibitor",-0.38519,-0.939,0.517,1146,0.821,"dinaciclib, BMS.265246, arcyriaflavin.a, ribociclib, palbociclib, abemaciclib, aminopurvalanol.a",0.286509456906058,0.0856568428805592,FALSE +"HCC95","Pearson.est","CHK inhibitor",-0.78913,-1.91,0.00296,1418,0.161,"SCH.900776, LY2603618, LY2606368, AZD7762",2.52870828894106,0.79317412396815,TRUE +"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.22212,-0.543,0.962,987,0.977,"ketoprofen, metoxibutropate, piroxicam, indoprofen, tepoxalin, FR.122047, acetylsalicylsalicylic.acid",0.0168249279621871,0.0101054362812269,FALSE +"HCC95","Pearson.est","cytochrome P450 inhibitor",0.45632,1.26,0.204,19,0.673,"morin",0.690369832574101,0.171984935776023,FALSE +"HCC95","Pearson.est","DNA alkylating agent",-0.38497,-0.94,0.504,1077,0.843,"dianhydrogalactitol, cyclophosphamide, streptozotocin, satraplatin, melphalan, mitomycin.c",0.297569463554475,0.0741724253752577,FALSE +"HCC95","Pearson.est","DNA inhibitor",0.35148,0.94,0.497,191,0.786,"mechlorethamine, sangivamycin, metronidazole, tirapazamine, bendamustine, carmustine, nithiamide",0.303643611266668,0.104577453960592,FALSE +"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.28763,-0.7,0.804,1106,0.908,"RG108, decitabine",0.0947439512515487,0.0419141514789149,FALSE +"HCC95","Pearson.est","DNA polymerase inhibitor",0.50254,1.35,0.155,137,0.815,"foscarnet, famciclovir",0.809668301829709,0.0888423912600234,FALSE +"HCC95","Pearson.est","DNA synthesis inhibitor",-0.55736,-1.34,0.148,1200,0.597,"floxuridine, anisomycin, cyclocytidine, CB.10.277, enocitabine, mitomycin.c",0.829738284605043,0.224025668870631,FALSE +"HCC95","Pearson.est","dopamine receptor antagonist",0.32266,0.864,0.59,296,0.801,"sertindole, isofloxythepin, clebopride, thioproperazine, mesoridazine, domperidone, lurasidone, ziprasidone",0.229147988357856,0.0963674839157623,FALSE +"HCC95","Pearson.est","estrogen receptor agonist",-0.30443,-0.744,0.796,1167,0.907,"PPT, estradiol",0.0990869322623309,0.0423927129399047,FALSE +"HCC95","Pearson.est","estrogen receptor antagonist",-0.33675,-0.818,0.668,998,0.958,"raloxifene, danazol, fulvestrant",0.175223537524454,0.0186344909214556,FALSE +"HCC95","Pearson.est","FGFR inhibitor",-0.31522,-0.773,0.763,1283,0.923,"nintedanib, AZD4547",0.11747546204512,0.0347982989740879,FALSE +"HCC95","Pearson.est","FLT3 inhibitor",-0.53046,-1.28,0.19,1135,0.623,"gilteritinib, KW.2449, ponatinib, sunitinib, quizartinib, tozasertib, midostaurin, lestaurtinib",0.721246399047171,0.20551195334083,FALSE +"HCC95","Pearson.est","glucocorticoid receptor agonist",0.16866,0.447,0.997,1208,0.995,"hydrocortisone, piretanide, triamcinolone.acetonide, betamethasone, dexamethasone.acetate, prednisolone.hemisuccinate, methylprednisolone, ciclesonide, desonide, deflazacort, fludroxycortide, flumethasone, difluprednate, halobetasol.propionate, rimexolone, flumethasone.pivalate, triamcinolone, clobetasol.propionate, halcinonide, prednisolone.acetate, prednisolone, fluticasone.propionate, beclomethasone.dipropionate, fluocinolone.acetonide, fluorometholone",0.00130484168834428,0.00217691925427455,FALSE +"HCC95","Pearson.est","glutamate receptor antagonist",0.35553,0.966,0.512,166,0.779,"ACDPP, felbamate, kynurenic.acid, latrepirdine",0.290730039024169,0.108462542327436,FALSE +"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.17931,0.483,0.993,84,1,"CHIR.98014",0.00305075150461883,0,FALSE +"HCC95","Pearson.est","growth factor receptor inhibitor",-0.56,-1.36,0.135,1293,0.589,"AZD3463, lestaurtinib",0.869666231504994,0.229884705212898,FALSE +"HCC95","Pearson.est","HCV inhibitor",0.34039,0.919,0.509,70,0.782,"daclatasvir",0.293282217663241,0.106793246940152,FALSE +"HCC95","Pearson.est","HDAC inhibitor",-0.69958,-1.71,0.0162,1233,0.251,"M.344, belinostat, PCI.24781, romidepsin, tacedinaline, AR.42, ACY.1215, resminostat, trichostatin.a, SB.939, JNJ.26481585, givinostat, entinostat, mocetinostat, dacinostat, RG2833",1.79048498545737,0.600326278518962,FALSE +"HCC95","Pearson.est","histamine receptor antagonist",-0.28322,-0.691,0.832,1376,0.902,"tiotidine, BF2.649",0.0798766737092761,0.0447934624580583,FALSE +"HCC95","Pearson.est","HMGCR inhibitor",-0.42061,-1.02,0.428,938,0.785,"pitavastatin, simvastatin",0.368556230986828,0.105130343254747,FALSE +"HCC95","Pearson.est","HSP inhibitor",-0.38972,-0.942,0.509,1175,0.863,"BIIB021, NVP.AUY922, ganetespib, VER.49009",0.293282217663241,0.0639892042847904,FALSE +"HCC95","Pearson.est","JAK inhibitor",-0.52588,-1.26,0.193,1331,0.632,"AZ960, AT.9283, tozasertib, lestaurtinib, PRT062070",0.714442690992226,0.199282921717615,FALSE +"HCC95","Pearson.est","KIT inhibitor",-0.5752,-1.4,0.106,1324,0.54,"KI.8751, telatinib, sunitinib, imatinib, midostaurin, vatalanib",0.97469413473523,0.267606240177031,FALSE +"HCC95","Pearson.est","MDM inhibitor",0.42895,1.17,0.262,449,0.706,"idasanutlin, AMG.232, nutlin.3, serdemetan",0.581698708680255,0.151195298948196,FALSE +"HCC95","Pearson.est","MEK inhibitor",-0.45922,-1.12,0.337,960,0.705,"PD.98059, AS.703026, refametinib, trametinib, cobimetinib, selumetinib, Ro.4987655, MEK162, AZD8330, nobiletin, PD.184352, TAK.733",0.472370099128661,0.151810883008601,FALSE +"HCC95","Pearson.est","MET inhibitor",-0.5044,-1.22,0.233,740,0.657,"LY2801653, INC.280, PHA.665752, NVP.BVU972, PF.04217903",0.632644078973981,0.182434630440219,FALSE +"HCC95","Pearson.est","microtubule inhibitor",-0.54361,-1.31,0.171,840,0.626,"estramustine.phosphate, colchicine, vinblastine, vinflunine, podophyllotoxin, secnidazole, cytochalasin.b, cabazitaxel, D.64131",0.767003889607846,0.20342566678957,FALSE +"HCC95","Pearson.est","mTOR inhibitor",0.26069,0.723,0.799,352,0.929,"AZD8055, torin.1, voxtalisib, AZD2014, WYE.125132, palomid.529, OSI.027, PP242, WYE.354, PF.05212384, PF.04691502, ku.0063794",0.0974532206860086,0.0319842860063582,FALSE +"HCC95","Pearson.est","NFkB pathway inhibitor",-0.22102,-0.533,0.962,1288,0.965,"Ro.106.9920, BAY.11.7082",0.0168249279621871,0.0154726866562074,FALSE +"HCC95","Pearson.est","opioid receptor agonist",0.3516,0.981,0.459,941,0.856,"spiradoline, trimebutine, salvinorin.a, ADL5859, cebranopadol, BW.180C",0.338187314462739,0.0675262353228468,FALSE +"HCC95","Pearson.est","p38 MAPK inhibitor",0.61886,1.71,0.0345,242,1,"SB.242235, talmapimod, skepinone.l, SB.239063",1.46218090492673,0,FALSE +"HCC95","Pearson.est","PARP inhibitor",-0.41484,-1.01,0.431,894,0.781,"AZD2461, niraparib, olaparib, talazoparib",0.365522729839268,0.1073489661227,FALSE +"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.50591,-1.23,0.229,1204,0.667,"ponatinib, SU014813, nintedanib, KI.8751, telatinib, sunitinib, imatinib, axitinib, vatalanib",0.640164517660112,0.175874166083451,FALSE +"HCC95","Pearson.est","phosphatase inhibitor",0.36448,0.98,0.443,205,0.801,"sodium.stibogluconate, alexidine, GSK2830371",0.35359627377693,0.0963674839157623,FALSE +"HCC95","Pearson.est","phosphodiesterase inhibitor",-0.38191,-0.923,0.547,1266,0.829,"trequinsin, GSK256066",0.262012673666569,0.0814454694497265,FALSE +"HCC95","Pearson.est","PI3K inhibitor",-0.30666,-0.734,0.772,1122,0.902,"TG100.115, PIK.75, GDC.0980, alpelisib, CUDC.907, SB.2343, taselisib, ZSTK.474",0.112382699664264,0.0447934624580583,FALSE +"HCC95","Pearson.est","PLK inhibitor",-0.6799,-1.66,0.026,1141,0.208,"volasertib, GW.843682X, rigosertib, BI.2536, GSK461364",1.58502665202918,0.681936665037238,TRUE +"HCC95","Pearson.est","potassium channel blocker",-0.42942,-1.04,0.424,1298,0.768,"mepivacaine, meglitinide",0.372634143407267,0.114638779968488,FALSE +"HCC95","Pearson.est","PPAR receptor agonist",0.29476,0.821,0.656,300,0.839,"pterostilbene, ciprofibrate, S26948",0.18309616062434,0.0762380391712997,FALSE +"HCC95","Pearson.est","progesterone receptor agonist",-0.32419,-0.79,0.727,800,0.938,"tanaproget, nomegestrol.acetate, melengestrol.acetate, norethindrone.acetate, danazol",0.138465589140962,0.0277971616209356,FALSE +"HCC95","Pearson.est","proteasome inhibitor",-0.47918,-1.19,0.251,1063,0.698,"carfilzomib, ixazomib, ixazomib.citrate",0.600326278518962,0.156144577376839,FALSE +"HCC95","Pearson.est","protein synthesis inhibitor",-0.32311,-0.788,0.725,889,0.919,"thiostrepton, mercaptopurine, chloramphenicol.palmitate, bruceantin, cycloheximide, anguidine, clindamycin.phosphate, homoharringtonine, puromycin, emetine",0.139661993429006,0.0366844886138887,FALSE +"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.42709,-1.04,0.409,1132,0.768,"rheochrysidin, NVP.TAE226, AV.412",0.388276691992658,0.114638779968488,FALSE +"HCC95","Pearson.est","RAF inhibitor",-0.33041,-0.81,0.685,1302,0.949,"AZ.628, CEP.32496, TAK.632",0.164309428507574,0.0227337875727074,FALSE +"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.4864,-1.17,0.284,975,0.653,"regorafenib, cabozantinib, sunitinib",0.546681659952962,0.185086818724926,FALSE +"HCC95","Pearson.est","retinoid receptor agonist",0.48297,1.26,0.215,310,0.673,"adapalene, bexarotene, tamibarotene, adarotene",0.667561540084395,0.171984935776023,FALSE +"HCC95","Pearson.est","ribonucleotide reductase inhibitor",-0.52132,-1.28,0.195,988,0.623,"triapine, hydroxyurea, cladribine, fludarabine, LY2334737, gemcitabine, clofarabine",0.709965388637482,0.20551195334083,FALSE +"HCC95","Pearson.est","serotonin receptor agonist",-0.76382,-1.86,0.00439,1447,0.138,"aripiprazole",2.35753547975788,0.860120913598763,TRUE +"HCC95","Pearson.est","serotonin receptor antagonist",-0.49193,-1.18,0.262,1317,0.689,"tropisetron, RS.16566, aripiprazole",0.581698708680255,0.161780778092374,FALSE +"HCC95","Pearson.est","sodium channel blocker",0.24209,0.678,0.876,430,0.952,"brivaracetam, ajmaline, A.803467, lappaconite, benzocaine, mexiletine, cibenzoline",0.0574958938319193,0.0213630516155257,FALSE +"HCC95","Pearson.est","src inhibitor",-0.46773,-1.14,0.316,1073,0.69,"masitinib, bosutinib, KX2.391",0.500312917381596,0.161150909262745,FALSE +"HCC95","Pearson.est","sterol demethylase inhibitor",0.3218,0.871,0.611,303,0.828,"sulconazole, posaconazole, chlormidazole, terconazole",0.213958789757446,0.0819696632151199,FALSE +"HCC95","Pearson.est","TGF beta receptor inhibitor",0.52407,1.41,0.135,66,0.838,"LY2109761",0.869666231504994,0.0767559813697235,FALSE +"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.33188,-0.807,0.697,698,0.931,"carmofur, raltitrexed, capecitabine, doxifluridine",0.156767221901991,0.0310503190186574,FALSE +"HCC95","Pearson.est","topoisomerase inhibitor",-0.68355,-1.69,0.0236,1187,0.235,"valrubicin, rubitecan, irinotecan, doxorubicin, licochalcone.a, exatecan.mesylate, mitoxantrone, amonafide, genz.644282, voreloxin, amsacrine, etoposide, camptothecin, TAS.103, daunorubicin, teniposide",1.62708799702989,0.628932137728264,TRUE +"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.59853,-1.46,0.101,1036,0.442,"vindesine, albendazole, podophyllotoxin, BNC105, fenbendazole, paclitaxel, vincristine, fosbretabulin, oxibendazole, ABT.751, verubulin, parbendazole, CYT.997, epothilone.b, docetaxel, dolastatin.10, combretastatin.A.4, KX2.391, plinabulin, epothilone.d",0.995678626217357,0.354577730650908,FALSE +"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.44581,-1.08,0.355,1132,0.737,"rheochrysidin, NVP.TAE226, AV.412, tyrphostin.AG.99, AMG.208, UNC2250, sunitinib, aminopurvalanol.a",0.449771646944906,0.132532512140949,FALSE +"HCC95","Pearson.est","VEGFR inhibitor",-0.36418,-0.896,0.576,1259,0.837,"SU014813, foretinib, nintedanib, KI.8751, telatinib, sunitinib, axitinib, vatalanib",0.239577516576788,0.07727454200674,FALSE +"HCC95","Pearson.est","vitamin D receptor agonist",-0.61771,-1.51,0.0616,1081,0.418,"paricalcitol, doxercalciferol, alfacalcidol, calcitriol, tacalcitol",1.21041928783557,0.378823718224965,FALSE +"H3255","Pearson.est","EGFR inhibitor",0.54273,1.42,0.12,174,0.385,"BMS.599626, tucatinib, CUDC.101, CP.724714, AEE788, BMS.690514, lapatinib, AZD8931, neratinib, AST.1306, WZ.4002, salvianolic.acid.B, dovitinib",0.920818753952375,0.414539270491499,FALSE +"H3255","Pearson.est","Abl kinase inhibitor",0.46027,1.17,0.275,371,0.435,"imatinib, flumatinib, ZM.306416, metatinib, dasatinib",0.560667306169737,0.361510743045363,FALSE +"H3255","Pearson.est","acetylcholine receptor agonist",0.35116,0.912,0.583,30,0.671,"oxiracetam",0.234331445240986,0.173277479831008,FALSE +"H3255","Pearson.est","acetylcholine receptor antagonist",-0.29795,-0.772,0.733,1045,1,"dicycloverine, methscopolamine, iododexetimide",0.134896025358872,0,FALSE +"H3255","Pearson.est","adenosine receptor antagonist",0.62569,1.62,0.04,389,0.462,"CGS.15943, sulmazole, SCH.58261, istradefylline, PSB.1115, MRS.1220",1.39794000867204,0.335358024443874,FALSE +"H3255","Pearson.est","adrenergic receptor agonist",-0.41907,-1.1,0.324,1269,0.664,"A61603, epinephrine, terbutaline, norepinephrine",0.489454989793388,0.177831920631982,FALSE +"H3255","Pearson.est","adrenergic receptor antagonist",0.51416,1.31,0.179,352,0.412,"practolol, atenolol...., RS.17053, dihydroergocristine, prazosin, dronedarone, pindolol, imiloxan",0.747146969020107,0.385102783966865,FALSE +"H3255","Pearson.est","AKT inhibitor",-0.27502,-0.711,0.802,1236,1,"GSK2110183, GDC.0068, MK.2206",0.0958256317158365,0,FALSE +"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.48859,1.27,0.207,254,0.41,"SB.505124, DMH1, AZD3463, NVP.TAE684, GW.788388",0.684029654543082,0.387216143280265,FALSE +"H3255","Pearson.est","androgen receptor antagonist",-0.28988,-0.763,0.735,418,1,"bicalutamide, cyproterone.acetate, RU.58841, flutamide, nilutamide, enzalutamide",0.133712660915805,0,FALSE +"H3255","Pearson.est","antioxidant",0.47298,1.23,0.221,195,0.413,"trolox, taurine",0.655607726314889,0.384049948343599,FALSE +"H3255","Pearson.est","AP inhibitor",0.46936,1.18,0.259,22,0.451,"tanshinone.i",0.586700235918748,0.345823458122039,FALSE +"H3255","Pearson.est","ATPase inhibitor",0.40295,1.01,0.423,234,0.554,"digoxin, ouabain, oligomycin.a, evodiamine",0.373659632624958,0.25649023527157,FALSE +"H3255","Pearson.est","Aurora kinase inhibitor",-0.22609,-0.573,0.943,1079,1,"CYC116, AMG900, aurora.a.inhibitor.i, MK.5108, GSK1070916, MLN.8054",0.0254883072626717,0,FALSE +"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.54322,1.4,0.122,293,0.39,"azalomycin.b, tedizolid, radezolid, tilmicosin, josamycin, valnemulin",0.913640169325252,0.408935392973501,FALSE +"H3255","Pearson.est","bacterial DNA gyrase inhibitor",-0.62744,-1.67,0.0513,963,0.458,"nadifloxacin, novobiocin, norfloxacin, sparfloxacin, lomefloxacin, finafloxacin",1.28988263488818,0.339134521996131,FALSE +"H3255","Pearson.est","BCL inhibitor",-0.47582,-1.25,0.221,1322,0.602,"TW.37, HA14.1",0.655607726314889,0.220403508742175,FALSE +"H3255","Pearson.est","Bcr.Abl kinase inhibitor",0.4576,1.17,0.284,371,0.435,"imatinib, flumatinib, metatinib, dasatinib",0.546681659952962,0.361510743045363,FALSE +"H3255","Pearson.est","benzodiazepine receptor agonist",0.44467,1.12,0.314,33,0.46,"ZK.93423, eprinomectin",0.503070351926785,0.337242168318426,FALSE +"H3255","Pearson.est","bromodomain inhibitor",0.31415,0.786,0.709,995,0.774,"I.BET.762, JQ1...., I.BET151, PFI.1, OTX015, bromosporine",0.149353764816933,0.111259039317107,FALSE +"H3255","Pearson.est","calcium channel blocker",0.56981,1.47,0.0824,420,0.395,"SKF.96365, tetrandrine, cinnarazine, efonidipine.monoethanolate, fendiline, carboxyamidotriazole, penfluridol",1.08407278830288,0.40340290437354,FALSE +"H3255","Pearson.est","CC chemokine receptor antagonist",0.40679,1.05,0.379,427,0.512,"SB.225002, RS.504393, PF.04136309",0.421360790031928,0.290730039024169,FALSE +"H3255","Pearson.est","CDK inhibitor",0.62229,1.57,0.0624,182,0.433,"BMS.387032, AT.7519, PHA.793887, JNJ.7706621, R547, CR8..R., indisulam, palbociclib, arcyriaflavin.a, ribociclib, AZD5438",1.20481541031758,0.363512103646635,FALSE +"H3255","Pearson.est","CHK inhibitor",-0.60702,-1.55,0.0716,1206,0.489,"CHIR.124, SCH.900776, LY2603618, LY2606368, AZD7762",1.14508697769214,0.31069114087638,FALSE +"H3255","Pearson.est","cyclooxygenase inhibitor",0.19675,0.496,0.979,8,0.979,"phenazone",0.00921730819686218,0.00921730819686218,FALSE +"H3255","Pearson.est","cytochrome P450 inhibitor",-0.34459,-0.884,0.576,1153,0.932,"itraconazole, cobicistat, eplerenone",0.239577516576788,0.0305840876460186,FALSE +"H3255","Pearson.est","DNA alkylating agent",-0.3405,-0.879,0.584,1023,0.9,"mitomycin.c, carboplatin, dacarbazine, melphalan, cyclophosphamide, satraplatin",0.233587152887601,0.0457574905606751,FALSE +"H3255","Pearson.est","DNA inhibitor",0.33756,0.882,0.595,300,0.699,"primaquine, nimorazole, bendamustine, mechlorethamine, pibenzimol, carmustine, oxaliplatin",0.22548303427145,0.155522824254319,FALSE +"H3255","Pearson.est","DNA methyltransferase inhibitor",0.48536,1.24,0.2,21,0.433,"SGI.1027",0.698970004336019,0.363512103646635,FALSE +"H3255","Pearson.est","DNA polymerase inhibitor",0.35668,0.931,0.518,152,0.659,"idoxuridine, foscarnet",0.285670240254767,0.18111458540599,FALSE +"H3255","Pearson.est","DNA synthesis inhibitor",-0.22233,-0.581,0.937,1434,1,"altretamine",0.0282604091122217,0,FALSE +"H3255","Pearson.est","dopamine receptor antagonist",-0.37702,-0.977,0.463,1154,0.87,"clebopride, raclopride, amisulpride, domperidone, remoxipride, oxiperomide, acetophenazine",0.334419008982047,0.0604807473813815,FALSE +"H3255","Pearson.est","estrogen receptor agonist",-0.44846,-1.15,0.296,886,0.655,"estradiol.cypionate, levonorgestrel, erteberel, ethinyl.estradiol, PPT, estradiol",0.528708288941061,0.183758700008217,FALSE +"H3255","Pearson.est","estrogen receptor antagonist",0.46522,1.19,0.259,148,0.452,"tamoxifen, clomifene",0.586700235918748,0.344861565188618,FALSE +"H3255","Pearson.est","FGFR inhibitor",0.69633,1.74,0.0178,334,0.285,"PD.173074, nintedanib, erdafitinib, lenvatinib, dovitinib, AZD4547, lucitanib, orantinib",1.74957999769111,0.54515513999149,FALSE +"H3255","Pearson.est","FLT3 inhibitor",0.28839,0.745,0.782,405,0.795,"pacritinib, sunitinib, dovitinib, GTP.14564, TG.02, tandutinib, sorafenib, ENMD.2076",0.106793246940152,0.0996328713435297,FALSE +"H3255","Pearson.est","glucocorticoid receptor agonist",-0.42644,-1.11,0.315,971,0.686,"piretanide, clobetasol.propionate, fluorometholone, hydrocortisone, dexamethasone.acetate, desonide, fluocinolone.acetonide, fluticasone.propionate, flumethasone.pivalate, triamcinolone, prednisolone.acetate, ciclesonide, prednisolone, fludroxycortide",0.501689446210399,0.163675884293248,FALSE +"H3255","Pearson.est","glutamate receptor antagonist",0.29607,0.752,0.746,535,0.804,"IEM1754, felbamate, CGP.37849, JNJ.16259685, tiletamine, latrepirdine, CPP, ACDPP",0.127261172527331,0.0947439512515487,FALSE +"H3255","Pearson.est","glycogen synthase kinase inhibitor",0.41835,1.07,0.359,486,0.514,"CHIR.98014, TWS.119, CHIR.99021, kenpaullone",0.444905551421681,0.289036881004724,FALSE +"H3255","Pearson.est","growth factor receptor inhibitor",0.59688,1.54,0.0511,322,0.387,"danusertib, AZD3463, GSK1838705A, GSK1904529A",1.29157909986529,0.412289034981089,FALSE +"H3255","Pearson.est","HCV inhibitor",0.50717,1.28,0.209,327,0.433,"narlaprevir, embelin, daclatasvir",0.679853713888946,0.363512103646635,FALSE +"H3255","Pearson.est","HDAC inhibitor",-0.4657,-1.23,0.233,1118,0.591,"givinostat, panobinostat, mocetinostat, ACY.1215, SB.939, RG2833, chidamide, nexturastat.a, entinostat, tacedinaline, JNJ.26481585",0.632644078973981,0.228412519118745,FALSE +"H3255","Pearson.est","histamine receptor antagonist",-0.26334,-0.682,0.824,1207,1,"terfenadine, cyproheptadine, famotidine, lafutidine",0.0840727883028842,0,FALSE +"H3255","Pearson.est","HMGCR inhibitor",-0.64083,-1.65,0.0459,1030,0.382,"lovastatin, mevastatin, simvastatin, pitavastatin, fluvastatin",1.33818731446274,0.417936637088291,FALSE +"H3255","Pearson.est","HSP inhibitor",-0.23474,-0.612,0.904,1331,1,"VER.49009, BIIB021",0.0438315695246367,0,FALSE +"H3255","Pearson.est","JAK inhibitor",0.28782,0.737,0.789,330,0.788,"pacritinib, AZD1480, filgotinib, TG.02, AZ960",0.10292299679058,0.103473782510445,FALSE +"H3255","Pearson.est","KIT inhibitor",0.58953,1.54,0.075,377,0.387,"pazopanib, imatinib, sunitinib, masitinib, OSI.930, lenvatinib, motesanib, cediranib, tandutinib, dasatinib, sorafenib",1.1249387366083,0.412289034981089,FALSE +"H3255","Pearson.est","MDM inhibitor",-0.38003,-0.974,0.477,1202,0.83,"RITA, serdemetan",0.321481620959886,0.0809219076239261,FALSE +"H3255","Pearson.est","MEK inhibitor",-0.55088,-1.44,0.096,1080,0.544,"PD.0325901, PD.318088, AZD8330, refametinib, MEK162, PD.198306, Ro.4987655, TAK.733, BIX.02188, PD.184352, PD.98059",1.01772876696043,0.26440110030182,FALSE +"H3255","Pearson.est","MET inhibitor",0.56264,1.47,0.086,256,0.395,"AMG458, INC.280, NVP.BVU972, PHA.665752",1.06550154875643,0.40340290437354,FALSE +"H3255","Pearson.est","microtubule inhibitor",0.33259,0.839,0.661,512,0.714,"vinflunine, secnidazole, triclabendazole, cytochalasin.b, estramustine.phosphate",0.17979854051436,0.146301788223826,FALSE +"H3255","Pearson.est","mTOR inhibitor",0.4202,1.06,0.391,472,0.513,"WYE.354, WYE.125132, PF.05212384, AZD8055, voxtalisib, ku.0063794, AZD2014, XL388, MLN0128, PKI.179, GSK2126458, palomid.529, OSI.027, temsirolimus",0.407823242604133,0.289882634888184,FALSE +"H3255","Pearson.est","NFkB pathway inhibitor",-0.30875,-0.803,0.71,1247,1,"parthenolide...., BAY.11.7082, BAY.11.7085",0.148741651280925,0,FALSE +"H3255","Pearson.est","opioid receptor agonist",0.43955,1.13,0.3,120,0.46,"trimebutine, salvinorin.a",0.522878745280338,0.337242168318426,FALSE +"H3255","Pearson.est","p38 MAPK inhibitor",-0.49175,-1.27,0.2,1249,0.682,"SB.242235, TAK.715, CMPD.1",0.698970004336019,0.166215625343521,FALSE +"H3255","Pearson.est","PARP inhibitor",-0.56301,-1.5,0.103,1219,0.499,"AZD2461, AG.14361, niraparib, talazoparib, olaparib",0.987162775294828,0.30189945437661,FALSE +"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.53746,1.38,0.14,377,0.395,"pazopanib, imatinib, nintedanib, sunitinib, masitinib, crenolanib, lenvatinib, dovitinib, trapidil, motesanib, orantinib, tandutinib, dasatinib, sorafenib",0.853871964321762,0.40340290437354,FALSE +"H3255","Pearson.est","phosphatase inhibitor",-0.19307,-0.5,0.98,1239,1,"mycophenolate.mofetil, bis.maltolato.oxovanadium.IV.",0.00877392430750515,0,FALSE +"H3255","Pearson.est","phosphodiesterase inhibitor",-0.50705,-1.34,0.147,1094,0.604,"YM.976, trequinsin, avanafil, papaverine, zardaverine, GSK256066",0.832682665251824,0.218963061378868,FALSE +"H3255","Pearson.est","PI3K inhibitor",0.33071,0.864,0.618,534,0.694,"CH5132799, PF.05212384, voxtalisib, TG.100713, BGT226, PKI.179, PI.828, GSK2126458, taselisib, buparlisib, CUDC.907, PIK.75, PF.04691502",0.209011524911184,0.158640529545145,FALSE +"H3255","Pearson.est","PLK inhibitor",0.53398,1.37,0.151,121,0.368,"NMS.1286937, volasertib",0.821023052706831,0.434152181326482,FALSE +"H3255","Pearson.est","potassium channel blocker",-0.34201,-0.906,0.553,1221,0.928,"ibutilide, meglitinide",0.257274868695302,0.0324520237811379,FALSE +"H3255","Pearson.est","PPAR receptor agonist",-0.50994,-1.35,0.161,1392,0.656,"clofibrate, pterostilbene",0.79317412396815,0.18309616062434,FALSE +"H3255","Pearson.est","progesterone receptor agonist",-0.65274,-1.72,0.0381,1199,1,"norgestrel, tanaproget, norethindrone, dienogest, norethindrone.acetate",1.41907502432438,0,FALSE +"H3255","Pearson.est","proteasome inhibitor",0.59705,1.57,0.0553,207,0.433,"oprozomib, bortezomib, MG.132",1.2572748686953,0.363512103646635,FALSE +"H3255","Pearson.est","protein synthesis inhibitor",-0.21236,-0.544,0.952,1316,1,"azomycin..2.nitroimidazole., emetine",0.0213630516155257,0,FALSE +"H3255","Pearson.est","protein tyrosine kinase inhibitor",0.75495,1.99,0,44,0.0701,"BMS.599626, CP.724714, mubritinib",Inf,1.15428198203334,TRUE +"H3255","Pearson.est","RAF inhibitor",0.53254,1.37,0.145,416,0.368,"dabrafenib, SB.590885, GDC.0879, LGX818, sorafenib, AZ.628",0.838631997765025,0.434152181326482,FALSE +"H3255","Pearson.est","RET tyrosine kinase inhibitor",0.57702,1.47,0.108,579,0.395,"sunitinib, apatinib, sorafenib, regorafenib, cabozantinib",0.96657624451305,0.40340290437354,FALSE +"H3255","Pearson.est","retinoid receptor agonist",-0.48459,-1.26,0.207,1157,0.636,"AM.580, tamibarotene, LE.135, adapalene",0.684029654543082,0.196542884351586,FALSE +"H3255","Pearson.est","ribonucleotide reductase inhibitor",0.33844,0.866,0.607,506,0.708,"fludarabine.phosphate, cytarabine, pentostatin, LY2334737, gemcitabine",0.216811308924742,0.149966742310231,FALSE +"H3255","Pearson.est","serotonin receptor agonist",0.74022,1.92,0.00992,46,0.0954,"aripiprazole, ipsapirone",2.00348832784582,1.0204516252959,TRUE +"H3255","Pearson.est","serotonin receptor antagonist",0.43993,1.14,0.306,1,0.462,"aripiprazole",0.51427857351842,0.335358024443874,FALSE +"H3255","Pearson.est","sodium channel blocker",-0.27343,-0.704,0.831,1225,1,"A.803467, mexiletine, benzethonium",0.080398976215889,0,FALSE +"H3255","Pearson.est","src inhibitor",0.56068,1.44,0.0975,241,0.38,"TG.100572, saracatinib, masitinib, PP.1, ZM.306416",1.01099538430146,0.42021640338319,FALSE +"H3255","Pearson.est","sterol demethylase inhibitor",-0.65219,-1.68,0.0304,1424,0.653,"terconazole, lanoconazole",1.51712641639125,0.185086818724926,FALSE +"H3255","Pearson.est","TGF beta receptor inhibitor",0.78709,2.05,0.00192,222,0.0826,"LY2109761, SB.431542, repsox, adaprev, D.4476",2.71669877129645,1.08301995267962,TRUE +"H3255","Pearson.est","thymidylate synthase inhibitor",0.4838,1.23,0.224,459,0.413,"capecitabine, raltitrexed, carmofur, trifluridine",0.649751981665837,0.384049948343599,FALSE +"H3255","Pearson.est","topoisomerase inhibitor",-0.46282,-1.18,0.242,1113,0.642,"camptothecin, rubitecan, amsacrine, teniposide, amonafide, voreloxin, mitoxantrone, etoposide, epirubicin, genz.644282, doxorubicin, TAS.103, beta.lapachone",0.616184634019569,0.192464971931147,FALSE +"H3255","Pearson.est","tubulin polymerization inhibitor",-0.16097,-0.419,0.998,1182,0.996,"CYT.997, verubulin, dolastatin.10, podophyllotoxin, BNC105",0.000869458712628891,0.00174066157630127,FALSE +"H3255","Pearson.est","tyrosine kinase inhibitor",0.49909,1.27,0.197,377,0.41,"BMS.599626, CP.724714, mubritinib, sunitinib, apatinib, tivantinib, GTP.14564, tyrphostin.A9, dasatinib, sorafenib",0.705533773838407,0.387216143280265,FALSE +"H3255","Pearson.est","VEGFR inhibitor",0.51788,1.35,0.147,334,0.377,"foretinib, PD.173074, pazopanib, TG.100572, AEE788, nintedanib, BMS.690514, golvatinib, sunitinib, OSI.930, lenvatinib, dovitinib, XL.647, tivozanib, ZM.306416, lucitanib, motesanib, cediranib, orantinib",0.832682665251824,0.423658649794207,FALSE +"H3255","Pearson.est","vitamin D receptor agonist",0.54682,1.44,0.105,413,0.38,"tacalcitol, alfacalcidol, maxacalcitol, doxercalciferol",0.978810700930062,0.42021640338319,FALSE +"H1648","Pearson.est","EGFR inhibitor",0.20896,0.538,0.944,305,1,"AEE788, CUDC.101, GW.583340, tucatinib, BMS.690514, lapatinib, XL.647, AZD8931, AST.1306, osimertinib",0.025028005701931,0,FALSE +"H1648","Pearson.est","Abl kinase inhibitor",-0.37303,-0.958,0.495,1225,0.852,"ponatinib, tozasertib, nilotinib, KW.2449",0.305394801066431,0.0695604052332999,FALSE +"H1648","Pearson.est","acetylcholine receptor agonist",-0.56603,-1.46,0.0956,1145,0.443,"tremorine, nicotine",1.0195421077239,0.35359627377693,FALSE +"H1648","Pearson.est","acetylcholine receptor antagonist",-0.31283,-0.79,0.709,1059,0.965,"methscopolamine, iododexetimide, dicycloverine",0.149353764816933,0.0154726866562074,FALSE +"H1648","Pearson.est","adenosine receptor antagonist",0.43305,1.11,0.33,214,0.715,"PSB.1115, sulmazole, CGS.15943",0.481486060122112,0.145693958198919,FALSE +"H1648","Pearson.est","adrenergic receptor agonist",-0.38621,-0.993,0.421,1148,0.843,"terbutaline, metaraminol, isoxsuprine, norepinephrine, epinephrine, isoetharine",0.375717904164332,0.0741724253752577,FALSE +"H1648","Pearson.est","adrenergic receptor antagonist",0.50878,1.31,0.177,291,0.559,"practolol, RS.17053, propranolol, oxprenolol, prazosin, atenolol...., dihydroergocristine",0.752026733638193,0.252588192113577,FALSE +"H1648","Pearson.est","AKT inhibitor",0.19632,0.498,0.977,91,1,"palomid.529",0.0101054362812269,0,FALSE +"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.42487,1.13,0.301,423,0.766,"SB.505124, AZD3463, DMH1, GW.788388, AP26113",0.521433504406157,0.115771230367396,FALSE +"H1648","Pearson.est","androgen receptor antagonist",0.55089,1.43,0.116,7,0.557,"bicalutamide",0.935542010773082,0.254144804826271,FALSE +"H1648","Pearson.est","antioxidant",-0.28928,-0.744,0.772,1279,0.933,"trolox",0.112382699664264,0.0301183562535,FALSE +"H1648","Pearson.est","AP inhibitor",-0.3474,-0.87,0.609,1409,0.904,"idronoxil",0.215382707367125,0.0438315695246367,FALSE +"H1648","Pearson.est","ATPase inhibitor",-0.43494,-1.09,0.346,1378,0.784,"digitoxigenin, rabeprazole, digitoxin",0.460923901207223,0.105683937315562,FALSE +"H1648","Pearson.est","Aurora kinase inhibitor",-0.63369,-1.59,0.0505,1015,0.389,"barasertib.HQPA, alisertib, CYC116, MK.5108, barasertib, PHA.680632, CCT137690, PF.03814735, tozasertib, hesperadin, SNS.314, TAK.901, MLN.8054, AT.9283, AMG900, GSK1070916, MK.8745, KW.2449",1.29670862188134,0.410050398674292,FALSE +"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.46618,1.19,0.254,73,0.69,"tilmicosin, josamycin",0.595166283380062,0.161150909262745,FALSE +"H1648","Pearson.est","bacterial DNA gyrase inhibitor",-0.3093,-0.776,0.736,1437,0.933,"sarafloxacin",0.133122185662501,0.0301183562535,FALSE +"H1648","Pearson.est","BCL inhibitor",-0.70378,-1.77,0.0159,1233,0.368,"gossypol, HA14.1, venetoclax, TW.37",1.79860287567955,0.434152181326482,FALSE +"H1648","Pearson.est","Bcr.Abl kinase inhibitor",-0.34722,-0.904,0.533,1225,0.934,"ponatinib, tozasertib, nilotinib",0.273272790973428,0.0296531237699066,FALSE +"H1648","Pearson.est","benzodiazepine receptor agonist",0.38669,1.02,0.413,288,0.78,"eprinomectin, ZK.93423, gamma.aminobutyric.acid, indiplon, CL.218872",0.384049948343599,0.10790539730952,FALSE +"H1648","Pearson.est","bromodomain inhibitor",-0.72968,-1.81,0.00865,1154,0.569,"JQ1...., I.BET.762, PFI.1, bromosporine, I.BET151",2.06298389253519,0.244887733604929,FALSE +"H1648","Pearson.est","calcium channel blocker",0.42558,1.11,0.336,420,0.715,"fendiline, carboxyamidotriazole, penfluridol, SR.33805, cinnarazine, SKF.96365",0.473660722610156,0.145693958198919,FALSE +"H1648","Pearson.est","CC chemokine receptor antagonist",0.5398,1.42,0.111,577,0.515,"ZK811752, MK.0812, UNBS.5162, SB.225002, RS.504393, PF.04136309",0.954677021213343,0.288192770958809,FALSE +"H1648","Pearson.est","CDK inhibitor",-0.55919,-1.42,0.11,1198,0.435,"P276.00, indirubin, TG.02, JNJ.7706621, AZD5438, palbociclib, ribociclib, BMS.265246, aminopurvalanol.a, abemaciclib, PHA.848125",0.958607314841775,0.361510743045363,FALSE +"H1648","Pearson.est","CHK inhibitor",-0.69525,-1.76,0.0226,1273,0.266,"AZD7762, LY2603618, LY2606368, SCH.900776",1.6458915608526,0.575118363368933,FALSE +"H1648","Pearson.est","cyclooxygenase inhibitor",-0.30654,-0.781,0.745,904,0.952,"naproxen, suxibuzone, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, tepoxalin, FK.3311, ketoprofen, AM.404, aspirin, amfenac, curcumin",0.127843727251707,0.0213630516155257,FALSE +"H1648","Pearson.est","cytochrome P450 inhibitor",0.32053,0.845,0.626,203,0.825,"itraconazole, PF.4981517",0.20342566678957,0.0835460514500749,FALSE +"H1648","Pearson.est","DNA alkylating agent",-0.3442,-0.881,0.593,1219,0.946,"mitomycin.c, melphalan, satraplatin, cyclophosphamide",0.226945306635737,0.0241088635982073,FALSE +"H1648","Pearson.est","DNA inhibitor",0.39801,1.04,0.386,319,0.779,"bendamustine, chlorambucil, carmustine, tirapazamine, oxaliplatin, metronidazole, sangivamycin",0.413412695328245,0.108462542327436,FALSE +"H1648","Pearson.est","DNA methyltransferase inhibitor",0.45478,1.2,0.234,103,0.722,"RG108, SGI.1027",0.630784142589857,0.141462802430361,FALSE +"H1648","Pearson.est","DNA polymerase inhibitor",-0.3249,-0.808,0.688,1160,0.962,"menadione, famciclovir",0.162411561764489,0.0168249279621871,FALSE +"H1648","Pearson.est","DNA synthesis inhibitor",-0.23752,-0.607,0.917,1219,0.982,"mitomycin.c, cyclocytidine, altretamine",0.0376306643299789,0.00788851221305034,FALSE +"H1648","Pearson.est","dopamine receptor antagonist",-0.27558,-0.708,0.826,1077,0.961,"ziprasidone, oxiperomide, UH.232...., remoxipride, raclopride, amisulpride",0.0830199526796178,0.0172766123314547,FALSE +"H1648","Pearson.est","estrogen receptor agonist",0.37492,0.98,0.469,425,0.723,"equol, estrone, estradiol.cypionate, levonorgestrel",0.328827157284917,0.140861702705469,FALSE +"H1648","Pearson.est","estrogen receptor antagonist",0.63023,1.67,0.0323,322,0.523,"toremifene, raloxifene, danazol, tamoxifen",1.4907974776689,0.281498311132726,FALSE +"H1648","Pearson.est","FGFR inhibitor",0.62746,1.66,0.0308,442,0.413,"erdafitinib, PD.173074, lucitanib, MK.2461, nintedanib, lenvatinib, regorafenib, AZD4547",1.51144928349956,0.384049948343599,FALSE +"H1648","Pearson.est","FLT3 inhibitor",-0.53066,-1.36,0.146,1071,0.414,"quizartinib, pacritinib, sunitinib, gilteritinib, TG.02, ponatinib, lestaurtinib, tozasertib, KW.2449",0.835647144215563,0.382999658879101,FALSE +"H1648","Pearson.est","glucocorticoid receptor agonist",-0.59755,-1.51,0.114,1337,0.441,"fludroxycortide, flumethasone.pivalate, triamcinolone, dexamethasone.acetate, fluticasone.propionate, desonide, fluocinolone.acetonide, prednisolone",0.943095148663527,0.355561410532161,FALSE +"H1648","Pearson.est","glutamate receptor antagonist",0.37626,0.973,0.469,199,0.706,"MTPG, CGP.37849, LY456236, felbamate",0.328827157284917,0.151195298948196,FALSE +"H1648","Pearson.est","glycogen synthase kinase inhibitor",0.28824,0.754,0.755,160,0.916,"CHIR.98014, CHIR.99021",0.122053048370812,0.0381045263321496,FALSE +"H1648","Pearson.est","growth factor receptor inhibitor",-0.48855,-1.23,0.226,1276,0.547,"lestaurtinib, PHA.848125",0.645891560852599,0.262012673666569,FALSE +"H1648","Pearson.est","HCV inhibitor",0.38002,0.991,0.442,116,0.734,"narlaprevir, embelin",0.354577730650908,0.134303940083929,FALSE +"H1648","Pearson.est","HDAC inhibitor",-0.48803,-1.24,0.216,1052,0.558,"resminostat, PCI.24781, AR.42, vorinostat, panobinostat, belinostat, dacinostat, R306465, givinostat, nexturastat.a, romidepsin, JNJ.26481585, trichostatin.a, RG2833",0.665546248849069,0.253365801062421,FALSE +"H1648","Pearson.est","histamine receptor antagonist",0.38084,0.993,0.416,204,0.8,"cimetidine, epinastine, nizatidine, tecastemizole, ranitidine",0.380906669373257,0.0969100130080564,FALSE +"H1648","Pearson.est","HMGCR inhibitor",0.29142,0.746,0.741,373,0.9,"simvastatin, mevastatin, atorvastatin",0.130181792020672,0.0457574905606751,FALSE +"H1648","Pearson.est","HSP inhibitor",-0.34,-0.876,0.589,1088,0.923,"VER.49009, XL888, BIIB021, NVP.AUY922, ganetespib",0.229884705212898,0.0347982989740879,FALSE +"H1648","Pearson.est","JAK inhibitor",-0.58132,-1.48,0.102,1205,0.45,"PRT062070, TG.02, lestaurtinib, AZ960, tozasertib, AT.9283, TG.101209, CEP.33779",0.991399828238082,0.346787486224656,FALSE +"H1648","Pearson.est","KIT inhibitor",-0.20913,-0.518,0.97,1084,0.971,"imatinib, sunitinib, telatinib, masitinib, vatalanib",0.0132282657337552,0.0127807700919951,FALSE +"H1648","Pearson.est","MDM inhibitor",-0.54415,-1.41,0.118,1344,0.418,"nutlin.3, serdemetan",0.928117992693875,0.378823718224965,FALSE +"H1648","Pearson.est","MEK inhibitor",-0.54587,-1.37,0.15,1224,0.424,"cobimetinib, AS.703026, AZD8330, refametinib, PD.0325901, trametinib, TAK.733, MEK162, nobiletin, BIX.02188, PD.184352",0.823908740944319,0.372634143407267,FALSE +"H1648","Pearson.est","MET inhibitor",0.38753,0.992,0.448,22,0.765,"AMG458",0.348721986001856,0.116338564846382,FALSE +"H1648","Pearson.est","microtubule inhibitor",-0.39899,-0.98,0.473,1049,0.837,"colchicine, vinblastine, D.64131, cytochalasin.b",0.325138859262188,0.07727454200674,FALSE +"H1648","Pearson.est","mTOR inhibitor",0.17116,0.448,0.998,462,1,"palomid.529, PF.05212384, voxtalisib, LY303511, WYE.354, deforolimus, GSK2126458, temsirolimus, sirolimus, everolimus, PKI.179, WYE.125132",0.000869458712628891,0,FALSE +"H1648","Pearson.est","NFkB pathway inhibitor",-0.54557,-1.38,0.144,1116,0.438,"BAY.11.7085, IKK.2.inhibitor.V, betulinic.acid, EVP4593, curcumin",0.84163750790475,0.3585258894959,FALSE +"H1648","Pearson.est","opioid receptor agonist",0.42344,1.1,0.346,12,0.695,"spiradoline",0.460923901207223,0.158015195409886,FALSE +"H1648","Pearson.est","p38 MAPK inhibitor",-0.31733,-0.815,0.684,803,0.98,"SB.239063, TAK.715, CMPD.1, skepinone.l",0.164943898279884,0.00877392430750515,FALSE +"H1648","Pearson.est","PARP inhibitor",-0.638,-1.64,0.0506,1127,0.349,"AZD2461, endo.IWR.1, olaparib, niraparib, talazoparib",1.2958494831602,0.45717457304082,FALSE +"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.26421,-0.673,0.848,1084,0.958,"imatinib, SU014813, sunitinib, telatinib, masitinib, ponatinib, axitinib, vatalanib",0.0716041477432862,0.0186344909214556,FALSE +"H1648","Pearson.est","phosphatase inhibitor",-0.30505,-0.775,0.73,1026,0.909,"bis.maltolato.oxovanadium.IV., alexidine, menadione, CID.5458317, mycophenolate.mofetil",0.136677139879544,0.0414361167780325,FALSE +"H1648","Pearson.est","phosphodiesterase inhibitor",-0.26324,-0.665,0.861,1326,0.944,"avanafil, GSK256066",0.0649968485463452,0.025028005701931,FALSE +"H1648","Pearson.est","PI3K inhibitor",-0.20776,-0.53,0.963,1080,0.989,"ZSTK.474, idelalisib, PI.103, SB.2343, NVP.BEZ235, TG100.115, YM.201636, pilaralisib",0.0163737128754655,0.0048037084028206,FALSE +"H1648","Pearson.est","PLK inhibitor",-0.41655,-1.06,0.397,1029,0.774,"HMN.214, rigosertib, GW.843682X",0.401209493236885,0.111259039317107,FALSE +"H1648","Pearson.est","potassium channel blocker",0.58647,1.51,0.0811,264,0.468,"mepivacaine, dofetilide, ML133, oleoylethanolamide",1.09097914578884,0.329754146925876,FALSE +"H1648","Pearson.est","PPAR receptor agonist",0.5323,1.4,0.141,301,0.497,"fenofibrate, oleoylethanolamide, GW.501516, pterostilbene",0.85078088734462,0.303643611266668,FALSE +"H1648","Pearson.est","progesterone receptor agonist",-0.66028,-1.66,0.0354,1114,0.392,"norethindrone.acetate, melengestrol.acetate, tanaproget, nomegestrol.acetate, norethindrone, dienogest, norgestrel",1.45099673797421,0.406713932979543,FALSE +"H1648","Pearson.est","proteasome inhibitor",-0.55988,-1.42,0.104,1147,0.435,"ixazomib, carfilzomib, oprozomib, ixazomib.citrate",0.98296666070122,0.361510743045363,FALSE +"H1648","Pearson.est","protein synthesis inhibitor",0.24288,0.636,0.888,174,1,"clofoctol, brefeldin.a, puromycin",0.051587034221399,0,FALSE +"H1648","Pearson.est","protein tyrosine kinase inhibitor",-0.42506,-1.07,0.338,951,0.789,"PP.121, rheochrysidin, AV.412, NVP.TAE226",0.471083299722345,0.10292299679058,FALSE +"H1648","Pearson.est","RAF inhibitor",0.23693,0.619,0.895,504,1,"LGX818, dabrafenib, GDC.0879, regorafenib, AZ.628, sorafenib",0.048176964684088,0,FALSE +"H1648","Pearson.est","RET tyrosine kinase inhibitor",0.33339,0.872,0.597,504,0.835,"cabozantinib, regorafenib, apatinib, sorafenib",0.224025668870631,0.0783135245163979,FALSE +"H1648","Pearson.est","retinoid receptor agonist",0.67134,1.78,0.0252,237,0.83,"fenretinide, bexarotene, tamibarotene, adapalene, AM.580",1.59859945921846,0.0809219076239261,FALSE +"H1648","Pearson.est","ribonucleotide reductase inhibitor",0.51749,1.33,0.178,366,0.568,"fludarabine.phosphate, cytarabine, triapine, gemcitabine, cladribine",0.749579997691106,0.245651664288981,FALSE +"H1648","Pearson.est","serotonin receptor agonist",-0.60396,-1.52,0.0755,1282,0.478,"pardoprunox, aripiprazole",1.12205304837081,0.320572103387881,FALSE +"H1648","Pearson.est","serotonin receptor antagonist",-0.51447,-1.3,0.193,1443,0.482,"aripiprazole, tropisetron",0.714442690992226,0.31695296176115,FALSE +"H1648","Pearson.est","sodium channel blocker",0.33409,0.86,0.626,218,0.827,"mepivacaine, cibenzoline, oxcarbazepine, triamterene",0.20342566678957,0.0824944904474534,FALSE +"H1648","Pearson.est","src inhibitor",0.3573,0.922,0.534,208,0.773,"TG.100572, ZM.306416, dasatinib",0.272458742971444,0.111820506081675,FALSE +"H1648","Pearson.est","sterol demethylase inhibitor",-0.27679,-0.703,0.822,1178,0.944,"sulconazole, ketoconazole",0.0851281824599496,0.025028005701931,FALSE +"H1648","Pearson.est","TGF beta receptor inhibitor",0.67211,1.76,0.0246,68,0.471,"LY2109761, repsox",1.60906489289662,0.326979092871104,FALSE +"H1648","Pearson.est","thymidylate synthase inhibitor",0.59805,1.57,0.0644,316,0.422,"doxifluridine, raltitrexed, ftorafur",1.19111413264019,0.374687549038326,FALSE +"H1648","Pearson.est","topoisomerase inhibitor",-0.22356,-0.557,0.942,882,0.996,"fleroxacin, irinotecan, teniposide, doxorubicin, daunorubicin, valrubicin, amsacrine, genz.644282, beta.lapachone, amonafide, voreloxin, TAS.103",0.0259490972071227,0.00174066157630127,FALSE +"H1648","Pearson.est","tubulin polymerization inhibitor",-0.39565,-1.01,0.422,1004,0.843,"combretastatin.A.4, nocodazole, albendazole, ABT.751, flubendazole, vindesine, BNC105, vinblastine, KX2.391, verubulin, fosbretabulin, epothilone.d",0.374687549038326,0.0741724253752577,FALSE +"H1648","Pearson.est","tyrosine kinase inhibitor",0.1597,0.417,0.998,208,0.996,"cabozantinib, GTP.14564, bafetinib, dasatinib",0.000869458712628891,0.00174066157630127,FALSE +"H1648","Pearson.est","VEGFR inhibitor",0.32479,0.844,0.648,388,0.8,"TG.100572, ZM.306416, AEE788, cabozantinib, cediranib, pazopanib, BMS.690514, PD.173074, XL.647, motesanib, lucitanib, MK.2461, nintedanib, lenvatinib, regorafenib, MGCD.265",0.188424994129407,0.0969100130080564,FALSE +"H1648","Pearson.est","vitamin D receptor agonist",0.62527,1.65,0.0458,410,0.345,"maxacalcitol, tacalcitol, doxercalciferol, ercalcitriol, paricalcitol",1.33913452199613,0.462180904926726,FALSE +"H1975","Pearson.est","EGFR inhibitor",-0.2474,-0.606,0.916,1080,0.951,"brigatinib, WZ.4002, OSI.420, pelitinib, tyrphostin.AG.1478, BIBX.1382, CGP.52411, vandetanib, icotinib, CNX.2006, WZ8040, rociletinib",0.0381045263321496,0.0218194830625861,FALSE +"H1975","Pearson.est","Abl kinase inhibitor",-0.5492,-1.33,0.152,1073,0.515,"imatinib, GZD824, flumatinib, ponatinib, bosutinib, KW.2449, tozasertib",0.818156412055227,0.288192770958809,FALSE +"H1975","Pearson.est","acetylcholine receptor agonist",-0.56553,-1.4,0.0828,838,0.552,"pilocarpine, oxiracetam, xanomeline, tremorine, nicotine",1.08196966321512,0.258060922270801,FALSE +"H1975","Pearson.est","acetylcholine receptor antagonist",0.32454,0.938,0.512,103,0.691,"hyoscyamine, darifenacin",0.290730039024169,0.160521952625802,FALSE +"H1975","Pearson.est","adenosine receptor antagonist",0.58481,1.7,0.0469,170,0.255,"PSB.1115, SCH.58261, CGS.15943, MRS.1220",1.32882715728492,0.593459819566045,FALSE +"H1975","Pearson.est","adrenergic receptor agonist",0.2253,0.663,0.872,68,0.871,"methyldopa, metaraminol",0.0594835150674328,0.0599818449923368,FALSE +"H1975","Pearson.est","adrenergic receptor antagonist",0.23992,0.701,0.841,111,0.875,"practolol, prazosin, atenolol....",0.0752040042020878,0.0579919469776868,FALSE +"H1975","Pearson.est","AKT inhibitor",-0.40749,-0.981,0.498,907,0.816,"triciribine, AZD5363, uprosertib, CCT128930, AT7867",0.302770657240282,0.0883098412461389,FALSE +"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41623,-1.02,0.446,1080,0.797,"brigatinib, lorlatinib, alectinib, AZD3463, AP26113",0.350665141287858,0.0985416786038876,FALSE +"H1975","Pearson.est","androgen receptor antagonist",-0.37122,-0.918,0.574,853,0.885,"flutamide, nilutamide",0.241088107602027,0.0530567293021746,FALSE +"H1975","Pearson.est","antioxidant",-0.54753,-1.36,0.124,952,0.537,"trolox, chlorogenic.acid, benfotiamine, mesna",0.906578314837765,0.270025714300444,FALSE +"H1975","Pearson.est","AP inhibitor",0.5033,1.54,0.0563,292,0.336,"tanshinone.i, birinapant, GDC.0152, embelin",1.24949160514865,0.473660722610156,FALSE +"H1975","Pearson.est","ATPase inhibitor",-0.23433,-0.566,0.948,1433,0.963,"digitoxin",0.0231916626619338,0.0163737128754655,FALSE +"H1975","Pearson.est","Aurora kinase inhibitor",-0.68329,-1.66,0.0153,1142,1,"MK.5108, MK.8745, MLN.8054, ZM.447439, TAK.901, CCT137690, PF.03814735, CCT129202, GSK1070916, alisertib, SNS.314, AMG900, KW.2449, hesperadin, tozasertib, AT.9283, CYC116",1.8153085691824,0,FALSE +"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.44247,-1.08,0.386,1034,0.776,"radezolid, tilmicosin, azalomycin.b, valnemulin",0.413412695328245,0.110138278741812,FALSE +"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.30146,-0.741,0.78,1233,0.974,"finafloxacin, novobiocin",0.10790539730952,0.0114410431213845,FALSE +"H1975","Pearson.est","BCL inhibitor",-0.60548,-1.51,0.0623,1254,0.531,"HA14.1, gossypol, TW.37",1.20551195334083,0.274905478918531,FALSE +"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.55372,-1.37,0.125,1073,0.549,"imatinib, GZD824, flumatinib, ponatinib, bosutinib, tozasertib",0.903089986991944,0.260427655549908,FALSE +"H1975","Pearson.est","benzodiazepine receptor agonist",0.48672,1.42,0.125,168,0.407,"gamma.aminobutyric.acid, eprinomectin, indiplon, CL.218872, ZK.93423, temazepam",0.903089986991944,0.39040559077478,FALSE +"H1975","Pearson.est","bromodomain inhibitor",-0.48039,-1.16,0.289,937,0.686,"OTX015, JQ1...., PFI.1, bromosporine",0.539102157243452,0.163675884293248,FALSE +"H1975","Pearson.est","calcium channel blocker",0.47565,1.4,0.124,34,0.361,"SKF.96365, fendiline, efonidipine.monoethanolate",0.906578314837765,0.442492798094342,FALSE +"H1975","Pearson.est","CC chemokine receptor antagonist",0.37281,1.14,0.264,1,0.452,"ZK811752",0.578396073130169,0.344861565188618,FALSE +"H1975","Pearson.est","CDK inhibitor",-0.35156,-0.868,0.633,1197,0.939,"indirubin, palbociclib, PHA.848125, abemaciclib, BMS.265246, aminopurvalanol.a",0.198596289982645,0.0273344077338891,FALSE +"H1975","Pearson.est","CHK inhibitor",-0.58438,-1.44,0.0824,979,0.603,"SCH.900776, SB.218078, AZD7762, LY2606368, LY2603618",1.08407278830288,0.219682687859849,FALSE +"H1975","Pearson.est","cyclooxygenase inhibitor",-0.49392,-1.21,0.245,1211,0.593,"aspirin, acetylsalicylsalicylic.acid, ketoprofen, FR.122047, piroxicam, tepoxalin",0.610833915635468,0.226945306635737,FALSE +"H1975","Pearson.est","cytochrome P450 inhibitor",-0.34405,-0.857,0.634,1191,0.94,"cobicistat, eplerenone",0.197910742118267,0.0268721464003014,FALSE +"H1975","Pearson.est","DNA alkylating agent",-0.40888,-1,0.478,962,0.816,"carboplatin, melphalan, satraplatin, streptozotocin, TH.302, cyclophosphamide",0.320572103387881,0.0883098412461389,FALSE +"H1975","Pearson.est","DNA inhibitor",-0.21391,-0.523,0.973,962,0.969,"carboplatin, melphalan, teroxirone, chlorambucil, valrubicin",0.0118871597316481,0.0136762229492347,FALSE +"H1975","Pearson.est","DNA methyltransferase inhibitor",-0.34393,-0.843,0.678,1220,0.945,"RG108, decitabine",0.168770306132937,0.0245681914907371,FALSE +"H1975","Pearson.est","DNA polymerase inhibitor",-0.41156,-0.99,0.477,955,0.818,"famciclovir, idoxuridine, cephalomannine, menadione",0.321481620959886,0.087246696328677,FALSE +"H1975","Pearson.est","DNA synthesis inhibitor",-0.32434,-0.793,0.739,1089,0.933,"cyclocytidine, artesunate, anisomycin, CB.10.277",0.131355561605174,0.0301183562535,FALSE +"H1975","Pearson.est","dopamine receptor antagonist",-0.3336,-0.806,0.726,1281,0.93,"raclopride, oxiperomide, thioproperazine, UH.232....",0.139063379299906,0.0315170514460649,FALSE +"H1975","Pearson.est","estrogen receptor agonist",-0.50733,-1.23,0.214,1118,0.571,"ethinyl.estradiol, estradiol.cypionate, estrone, PPT",0.669586226650809,0.243363891754152,FALSE +"H1975","Pearson.est","estrogen receptor antagonist",0.43481,1.28,0.212,821,0.32,"toremifene, tamoxifen, danazol, raloxifene, clomifene, fulvestrant",0.673664139071249,0.494850021680094,FALSE +"H1975","Pearson.est","FGFR inhibitor",-0.35552,-0.868,0.632,1339,0.939,"nintedanib, AZD4547",0.199282921717615,0.0273344077338891,FALSE +"H1975","Pearson.est","FLT3 inhibitor",-0.52649,-1.28,0.198,1293,0.529,"ponatinib, lestaurtinib, midostaurin, quizartinib, KW.2449, tozasertib",0.703334809738469,0.276544327964814,FALSE +"H1975","Pearson.est","glucocorticoid receptor agonist",-0.42474,-1.05,0.399,765,0.773,"prednisolone.acetate, desonide, prednisolone.hemisuccinate, flumethasone.pivalate, fluorometholone, rimexolone, dexamethasone.acetate, beclomethasone.dipropionate, halcinonide, clobetasol.propionate, triamcinolone, ciclesonide, methylprednisolone, fluticasone.propionate, fluocinolone.acetonide, prednisolone",0.399027104313252,0.111820506081675,FALSE +"H1975","Pearson.est","glutamate receptor antagonist",-0.24498,-0.61,0.909,1424,0.963,"SIB.1757",0.0414361167780325,0.0163737128754655,FALSE +"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.30051,-0.734,0.792,1117,0.966,"TWS.119, indirubin, tideglusib",0.101274818410506,0.0150228735845067,FALSE +"H1975","Pearson.est","growth factor receptor inhibitor",-0.61302,-1.52,0.0526,1057,0.695,"danusertib, GSK1838705A, PHA.848125, AZD3463, lestaurtinib",1.27901425584626,0.158015195409886,FALSE +"H1975","Pearson.est","HCV inhibitor",-0.25447,-0.63,0.901,1258,0.962,"narlaprevir",0.045275209020937,0.0168249279621871,FALSE +"H1975","Pearson.est","HDAC inhibitor",-0.5564,-1.37,0.12,980,0.549,"chidamide, SB.939, panobinostat, trichostatin.a, M.344, JNJ.26481585, entinostat, mocetinostat, vorinostat, dacinostat, belinostat, AR.42, givinostat, RG2833, resminostat, ACY.1215",0.920818753952375,0.260427655549908,FALSE +"H1975","Pearson.est","histamine receptor antagonist",-0.30853,-0.745,0.777,739,0.988,"famotidine, cyproheptadine, ebastine, levocetirizine, nizatidine, pheniramine, lafutidine, ICI.162846, terfenadine, BF2.649, tiotidine",0.109578981199086,0.00524305541237188,FALSE +"H1975","Pearson.est","HMGCR inhibitor",-0.6061,-1.51,0.0491,874,0.531,"atorvastatin, lovastatin, mevastatin, simvastatin, fluvastatin, pitavastatin",1.30891850787703,0.274905478918531,FALSE +"H1975","Pearson.est","HSP inhibitor",-0.63562,-1.58,0.0353,1041,0.78,"tanespimycin, SNX.5422, SNX.2112, XL888, NVP.AUY922, PU.H71, BIIB021, VER.49009, ganetespib",1.45222529461218,0.10790539730952,FALSE +"H1975","Pearson.est","JAK inhibitor",-0.52023,-1.28,0.168,1282,0.529,"filgotinib, lestaurtinib, AZ960, tozasertib, PRT062070, AT.9283",0.774690718274137,0.276544327964814,FALSE +"H1975","Pearson.est","KIT inhibitor",-0.37582,-0.93,0.548,1058,0.903,"telatinib, imatinib, masitinib, midostaurin, KI.8751, vatalanib",0.261219441515631,0.0443122496864942,FALSE +"H1975","Pearson.est","MDM inhibitor",-0.59293,-1.47,0.0764,855,0.579,"nutlin.3, AMG.232, serdemetan, idasanutlin, RITA, CGM097",1.11690664142431,0.237321436272564,FALSE +"H1975","Pearson.est","MEK inhibitor",-0.42763,-1.04,0.419,778,0.775,"PD.318088, AS.703026, trametinib, PD.198306, selumetinib, MEK162, PD.0325901, Ro.4987655, AZD8330, PD.98059, refametinib, TAK.733, PD.184352, nobiletin",0.377785977033705,0.11069829749369,FALSE +"H1975","Pearson.est","MET inhibitor",-0.3791,-0.926,0.569,1190,0.89,"PF.04217903",0.244887733604929,0.0506099933550872,FALSE +"H1975","Pearson.est","microtubule inhibitor",-0.46229,-1.12,0.349,1046,0.733,"podophyllotoxin, cytochalasin.b, cabazitaxel, vinblastine, D.64131",0.45717457304082,0.134896025358872,FALSE +"H1975","Pearson.est","mTOR inhibitor",0.45023,1.29,0.165,263,0.388,"voxtalisib, AZD8055, temsirolimus, deforolimus, PF.05212384, OSI.027, sirolimus, WYE.125132, PKI.179, WYE.354, XL388, PP242",0.782516055786094,0.411168274405793,FALSE +"H1975","Pearson.est","NFkB pathway inhibitor",-0.3325,-0.821,0.698,675,0.944,"bortezomib, IKK.2.inhibitor.V, EVP4593, Ro.106.9920, curcumin, BAY.11.7085, BAY.11.7082, betulinic.acid",0.156144577376839,0.025028005701931,FALSE +"H1975","Pearson.est","opioid receptor agonist",0.33287,0.992,0.427,968,0.646,"spiradoline, cebranopadol, ADL5859, BW.180C, trimebutine, salvinorin.a",0.369572124974976,0.189767482004916,FALSE +"H1975","Pearson.est","p38 MAPK inhibitor",-0.63305,-1.54,0.0451,1297,0.769,"CMPD.1, VX.702",1.34582345812204,0.114073660198569,FALSE +"H1975","Pearson.est","PARP inhibitor",-0.47453,-1.15,0.299,1327,0.686,"talazoparib, niraparib",0.52432881167557,0.163675884293248,FALSE +"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.52572,-1.28,0.182,1058,0.529,"telatinib, imatinib, trapidil, SU014813, masitinib, ponatinib, nintedanib, KI.8751, CP.673451, crenolanib, vatalanib, axitinib",0.739928612014925,0.276544327964814,FALSE +"H1975","Pearson.est","phosphatase inhibitor",-0.55401,-1.34,0.125,1325,0.519,"bis.maltolato.oxovanadium.IV., menadione, CID.5458317",0.903089986991944,0.284832642151542,FALSE +"H1975","Pearson.est","phosphodiesterase inhibitor",-0.28468,-0.686,0.839,1426,0.99,"GSK256066",0.0762380391712997,0.00436480540245009,FALSE +"H1975","Pearson.est","PI3K inhibitor",0.24161,0.714,0.808,234,0.912,"BGT226, voxtalisib, PF.05212384, AZD6482, CH5132799, idelalisib, PI.828, PKI.179, TG100.115",0.0925886392254138,0.0400051616715838,FALSE +"H1975","Pearson.est","PLK inhibitor",-0.67066,-1.65,0.014,1146,0.704,"volasertib, HMN.214, BI.2536, GSK461364, rigosertib",1.85387196432176,0.152427340857888,FALSE +"H1975","Pearson.est","potassium channel blocker",0.43591,1.28,0.188,65,0.32,"dofetilide, ML133",0.72584215073632,0.494850021680094,FALSE +"H1975","Pearson.est","PPAR receptor agonist",0.27464,0.807,0.656,145,0.819,"GW.501516, pterostilbene",0.18309616062434,0.0867160982395816,FALSE +"H1975","Pearson.est","progesterone receptor agonist",-0.33273,-0.82,0.702,751,0.927,"norethindrone, norethindrone.acetate, tanaproget, nomegestrol.acetate, norgestrel",0.153662887870195,0.0329202658555029,FALSE +"H1975","Pearson.est","proteasome inhibitor",-0.57568,-1.43,0.0838,1355,0.57,"ixazomib, ixazomib.citrate",1.07675598136972,0.244125144327509,FALSE +"H1975","Pearson.est","protein synthesis inhibitor",-0.33721,-0.823,0.696,1027,0.96,"anguidine, puromycin, homoharringtonine, thiostrepton, cycloheximide, mercaptopurine, emetine",0.157390760389438,0.0177287669604316,FALSE +"H1975","Pearson.est","protein tyrosine kinase inhibitor",-0.28437,-0.709,0.814,1035,0.98,"rheochrysidin, NVP.TAE226, PP.121",0.0893755951107988,0.00877392430750515,FALSE +"H1975","Pearson.est","RAF inhibitor",0.30073,0.867,0.58,121,0.769,"vemurafenib, GDC.0879, dabrafenib",0.236572006437063,0.114073660198569,FALSE +"H1975","Pearson.est","RET tyrosine kinase inhibitor",-0.531,-1.31,0.166,1284,0.534,"cabozantinib, vandetanib",0.779891911959945,0.272458742971444,FALSE +"H1975","Pearson.est","retinoid receptor agonist",0.57105,1.74,0.0287,307,0.327,"adarotene, bexarotene, tamibarotene, adapalene",1.54211810326601,0.485452247339714,FALSE +"H1975","Pearson.est","ribonucleotide reductase inhibitor",-0.50581,-1.23,0.226,1236,0.571,"hydroxyurea, fludarabine, clofarabine",0.645891560852599,0.243363891754152,FALSE +"H1975","Pearson.est","serotonin receptor agonist",-0.52027,-1.27,0.185,1447,0.529,"aripiprazole",0.732828271596986,0.276544327964814,FALSE +"H1975","Pearson.est","serotonin receptor antagonist",-0.42582,-1.05,0.415,1411,0.773,"RS.16566, aripiprazole",0.381951903287907,0.111820506081675,FALSE +"H1975","Pearson.est","sodium channel blocker",-0.25816,-0.631,0.895,938,0.977,"oxcarbazepine, quinidine, A.803467, mepivacaine",0.048176964684088,0.0101054362812269,FALSE +"H1975","Pearson.est","src inhibitor",-0.45993,-1.1,0.327,1234,0.755,"masitinib, KX2.391, bosutinib",0.485452247339714,0.122053048370812,FALSE +"H1975","Pearson.est","sterol demethylase inhibitor",-0.26733,-0.657,0.88,1315,0.986,"ketoconazole",0.0555173278498314,0.0061230850587888,FALSE +"H1975","Pearson.est","TGF beta receptor inhibitor",0.46453,1.32,0.142,171,0.402,"LY2109761, adaprev",0.847711655616944,0.39577394691553,FALSE +"H1975","Pearson.est","thymidylate synthase inhibitor",0.6879,2.06,0.018,346,0.171,"capecitabine, doxifluridine, carmofur, raltitrexed",1.74472749489669,0.767003889607846,TRUE +"H1975","Pearson.est","topoisomerase inhibitor",-0.55425,-1.35,0.121,942,0.528,"irinotecan, SN.38, amsacrine, epirubicin, mitoxantrone, rubitecan, genz.644282, idarubicin, teniposide, valrubicin, etoposide, voreloxin, licochalcone.a, camptothecin, daunorubicin, TAS.103, amonafide",0.91721462968355,0.277366077466188,FALSE +"H1975","Pearson.est","tubulin polymerization inhibitor",-0.57023,-1.4,0.101,1009,0.552,"paclitaxel, podophyllotoxin, nocodazole, flubendazole, oxibendazole, parbendazole, dolastatin.10, ABT.751, vinblastine, plinabulin, docetaxel, combretastatin.A.4, BNC105, verubulin, KX2.391, epothilone.b, fosbretabulin, epothilone.d",0.995678626217357,0.258060922270801,FALSE +"H1975","Pearson.est","tyrosine kinase inhibitor",-0.43489,-1.07,0.368,1035,0.776,"rheochrysidin, AMG.208, NVP.TAE226, PP.121, tyrphostin.AG.99, cabozantinib, vandetanib, UNC2250, aminopurvalanol.a",0.434152181326482,0.110138278741812,FALSE +"H1975","Pearson.est","VEGFR inhibitor",-0.28471,-0.685,0.849,1284,0.974,"cabozantinib, vandetanib, nintedanib, KI.8751, vatalanib, axitinib",0.0710923097560473,0.0114410431213845,FALSE +"H1975","Pearson.est","vitamin D receptor agonist",-0.26526,-0.65,0.886,758,0.976,"tacalcitol, paricalcitol, calcitriol, doxercalciferol, alfacalcidol",0.0525662781129492,0.0105501823333082,FALSE +"HCC78","Pearson.est","EGFR inhibitor",-0.38566,-0.937,0.574,718,0.791,"BMS.690514, gefitinib, CUDC.101, PD.168393, FERb.033, lapatinib, erlotinib, AEE788, afatinib, icotinib, canertinib, TAK.285, CP.724714, pelitinib, XL.647, tucatinib, brigatinib, vandetanib, osimertinib, neratinib, WZ8040, OSI.420, rociletinib, salvianolic.acid.B, PD.153035, BIBU.1361, BMS.599626",0.241088107602027,0.101823516502323,FALSE +"HCC78","Pearson.est","Abl kinase inhibitor",-0.59261,-1.42,0.0736,1311,0.785,"ponatinib, bosutinib, tozasertib, GZD824, KW.2449, flumatinib",1.1331221856625,0.105130343254747,FALSE +"HCC78","Pearson.est","acetylcholine receptor agonist",-0.47941,-1.17,0.271,975,0.694,"pilocarpine, nicotine, tremorine",0.567030709125594,0.158640529545145,FALSE +"HCC78","Pearson.est","acetylcholine receptor antagonist",-0.57558,-1.39,0.104,986,0.722,"iododexetimide, methscopolamine, dicycloverine, darifenacin",0.98296666070122,0.141462802430361,FALSE +"HCC78","Pearson.est","adenosine receptor antagonist",-0.47399,-1.14,0.298,1014,0.749,"istradefylline, PSB.1115, sulmazole",0.525783735923745,0.125518182300534,FALSE +"HCC78","Pearson.est","adrenergic receptor agonist",-0.49877,-1.21,0.229,946,0.667,"oxymetazoline, terbutaline, A61603, midodrine, isoxsuprine, metaraminol, clenbuterol, isoetharine, epinephrine, buphenine",0.640164517660112,0.175874166083451,FALSE +"HCC78","Pearson.est","adrenergic receptor antagonist",-0.19873,-0.484,0.978,610,1,"atipamezole, propranolol, oxprenolol, levobunolol, vincamine, carvedilol, pindolol, idazoxan, atenolol...., dronedarone",0.00966114521239857,0,FALSE +"HCC78","Pearson.est","AKT inhibitor",-0.29856,-0.729,0.816,849,0.919,"AT7867, triciribine, uprosertib, AZD5363, palomid.529, CCT128930",0.0883098412461389,0.0366844886138887,FALSE +"HCC78","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.56326,-1.36,0.108,1009,0.508,"AP26113, GW.788388, brigatinib, alectinib, DMH1, CEP.37440, AZD3463",0.96657624451305,0.294136287716081,FALSE +"HCC78","Pearson.est","androgen receptor antagonist",-0.36252,-0.883,0.618,770,0.828,"bicalutamide, cyproterone.acetate, flutamide",0.209011524911184,0.0819696632151199,FALSE +"HCC78","Pearson.est","antioxidant",-0.43787,-1.04,0.414,794,0.678,"rutin, mesna, benfotiamine, taurine",0.382999658879101,0.168770306132937,FALSE +"HCC78","Pearson.est","AP inhibitor",0.31797,0.958,0.5,29,0.803,"birinapant",0.301029995663981,0.095284454721319,FALSE +"HCC78","Pearson.est","ATPase inhibitor",0.41393,1.22,0.218,72,0.636,"k.strophanthidin, rabeprazole",0.661543506395395,0.196542884351586,FALSE +"HCC78","Pearson.est","Aurora kinase inhibitor",-0.53253,-1.27,0.159,983,0.591,"PF.03814735, barasertib, CYC116, CCT137690, danusertib, barasertib.HQPA, MK.8745, AT.9283, ZM.447439, alisertib, ENMD.2076, hesperadin, tozasertib, SNS.314, KW.2449",0.798602875679548,0.228412519118745,FALSE +"HCC78","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.56946,-1.37,0.104,1319,0.557,"azalomycin.b, tedizolid, dirithromycin",0.98296666070122,0.254144804826271,FALSE +"HCC78","Pearson.est","bacterial DNA gyrase inhibitor",-0.26705,-0.647,0.911,1168,0.987,"novobiocin, sarafloxacin",0.0404816230270017,0.00568284733036327,FALSE +"HCC78","Pearson.est","BCL inhibitor",-0.36057,-0.865,0.658,780,0.813,"ABT.737, HA14.1, TW.37, gossypol, navitoclax",0.181774106386044,0.0899094544059319,FALSE +"HCC78","Pearson.est","Bcr.Abl kinase inhibitor",-0.58483,-1.42,0.0919,898,0.785,"metatinib, imatinib, dasatinib, nilotinib, ponatinib, bosutinib, tozasertib, GZD824, flumatinib",1.03668448861389,0.105130343254747,FALSE +"HCC78","Pearson.est","benzodiazepine receptor agonist",0.3131,0.931,0.516,66,0.78,"bentazepam, ivermectin, eprinomectin",0.287350298372789,0.10790539730952,FALSE +"HCC78","Pearson.est","bromodomain inhibitor",-0.80106,-1.93,0,1307,0.0703,"PFI.1, bromosporine, I.BET151, JQ1...., I.BET.762",Inf,1.15304467498018,TRUE +"HCC78","Pearson.est","calcium channel blocker",-0.39792,-0.97,0.52,808,0.774,"tetrandrine, pranidipine, SKF.96365, efonidipine.monoethanolate, penfluridol, mibefradil",0.283996656365201,0.111259039317107,FALSE +"HCC78","Pearson.est","CC chemokine receptor antagonist",-0.35441,-0.867,0.655,730,0.825,"UNBS.5162, PF.04136309, SB.225002, navarixin, MK.0812, RS.504393",0.183758700008217,0.0835460514500749,FALSE +"HCC78","Pearson.est","CDK inhibitor",-0.58271,-1.38,0.0988,1088,0.571,"dinaciclib, BMS.387032, PHA.793887, AT.7519, PHA.848125, aminopurvalanol.a, kenpaullone, BMS.265246, P276.00, AZD5438, TG.02, ribociclib, palbociclib, JNJ.7706621, abemaciclib",1.00524305541237,0.243363891754152,FALSE +"HCC78","Pearson.est","CHK inhibitor",-0.42893,-1.05,0.413,891,0.673,"LY2606368, AZD7762, PF.477736, SB.218078",0.384049948343599,0.171984935776023,FALSE +"HCC78","Pearson.est","cyclooxygenase inhibitor",-0.35218,-0.843,0.666,1154,0.82,"ketoprofen, suxibuzone, ramifenazone, aspirin, FR.122047, piroxicam, phenazone",0.176525770829699,0.0861861476162833,FALSE +"HCC78","Pearson.est","cytochrome P450 inhibitor",-0.38458,-0.933,0.564,1140,0.768,"eplerenone, morin, itraconazole",0.248720896016658,0.114638779968488,FALSE +"HCC78","Pearson.est","DNA alkylating agent",-0.42685,-1.03,0.414,1132,0.682,"cisplatin, ifosfamide, streptozotocin, TH.302, estramustine",0.382999658879101,0.166215625343521,FALSE +"HCC78","Pearson.est","DNA inhibitor",-0.18285,-0.438,0.996,1402,0.993,"primaquine",0.00174066157630127,0.00305075150461883,FALSE +"HCC78","Pearson.est","DNA methyltransferase inhibitor",-0.49179,-1.18,0.249,828,0.722,"azacitidine, RG108, fdcyd, decitabine, SGI.1027",0.603800652904264,0.141462802430361,FALSE +"HCC78","Pearson.est","DNA polymerase inhibitor",-0.44452,-1.07,0.37,1325,0.68,"idoxuridine, trifluridine",0.431798275933005,0.167491087293764,FALSE +"HCC78","Pearson.est","DNA synthesis inhibitor",-0.21825,-0.522,0.98,597,1,"mitomycin.c, azodicarbonamide, CB.10.277, anisomycin, floxuridine, capecitabine, enocitabine, cisplatin, cyclocytidine",0.00877392430750515,0,FALSE +"HCC78","Pearson.est","dopamine receptor antagonist",0.22906,0.677,0.834,110,0.925,"clebopride, oxiperomide, thioproperazine, domperidone",0.0788339493622613,0.0338582672609674,FALSE +"HCC78","Pearson.est","estrogen receptor agonist",-0.2529,-0.607,0.918,845,1,"estrone, estradiol.cypionate, PPT, estradiol",0.0371573187987575,0,FALSE +"HCC78","Pearson.est","estrogen receptor antagonist",-0.38212,-0.936,0.551,1093,0.777,"tamoxifen, danazol, clomifene",0.258848401148215,0.109578981199086,FALSE +"HCC78","Pearson.est","FGFR inhibitor",-0.57521,-1.39,0.0958,1078,0.722,"PD.173074, AZD4547, MK.2461, lucitanib, nintedanib",1.01863449092146,0.141462802430361,FALSE +"HCC78","Pearson.est","FLT3 inhibitor",-0.55121,-1.33,0.117,1226,0.555,"lestaurtinib, tandutinib, ponatinib, ENMD.2076, TG.02, tozasertib, KW.2449, gilteritinib",0.931814138253838,0.255707016877324,FALSE +"HCC78","Pearson.est","glucocorticoid receptor agonist",0.35596,1.07,0.383,83,0.744,"hydrocortisone, triamcinolone.acetonide, piretanide, desonide",0.416801226031377,0.128427064454121,FALSE +"HCC78","Pearson.est","glutamate receptor antagonist",0.16948,0.522,0.968,84,0.978,"MTPG, latrepirdine",0.0141246426916063,0.00966114521239857,FALSE +"HCC78","Pearson.est","glycogen synthase kinase inhibitor",-0.45054,-1.1,0.338,850,0.751,"GSK.3.inhibitor.IX, tideglusib, LY2090314, CHIR.99021, kenpaullone",0.471083299722345,0.124360062995832,FALSE +"HCC78","Pearson.est","growth factor receptor inhibitor",-0.71742,-1.73,0.0104,1096,0.3,"danusertib, PHA.848125, lestaurtinib, GSK1904529A, AZD3463, GSK1838705A",1.98296666070122,0.522878745280338,FALSE +"HCC78","Pearson.est","HCV inhibitor",-0.32161,-0.769,0.784,996,0.9,"daclatasvir, narlaprevir, mericitabine",0.105683937315562,0.0457574905606751,FALSE +"HCC78","Pearson.est","HDAC inhibitor",-0.51485,-1.26,0.183,1172,0.587,"RGFP966, givinostat, belinostat, trichostatin.a, vorinostat, AR.42, dacinostat, resminostat, M.344, R306465, RG2833",0.737548910269571,0.231361898752386,FALSE +"HCC78","Pearson.est","histamine receptor antagonist",-0.31342,-0.76,0.778,1121,0.896,"cimetidine, ICI.162846, BF2.649, ebastine, tiotidine",0.109020403010311,0.0476919903378748,FALSE +"HCC78","Pearson.est","HMGCR inhibitor",0.46394,1.38,0.109,779,0.453,"fluvastatin, mevastatin, simvastatin, atorvastatin, pitavastatin, lovastatin",0.962573502059376,0.343901797987168,FALSE +"HCC78","Pearson.est","HSP inhibitor",-0.41759,-1.02,0.445,1021,0.687,"NVP.AUY922, VER.49009, SNX.2112, SNX.5422, XL888",0.351639989019068,0.16304326294045,FALSE +"HCC78","Pearson.est","JAK inhibitor",-0.58368,-1.38,0.0958,882,0.571,"TG.101209, filgotinib, atiprimod, AZ960, WHI.P154, pacritinib, AZD1480, baricitinib, lestaurtinib, PRT062070, AT.9283, TG.02, tozasertib",1.01863449092146,0.243363891754152,FALSE +"HCC78","Pearson.est","KIT inhibitor",-0.52623,-1.27,0.176,856,0.591,"sorafenib, telatinib, motesanib, regorafenib, sunitinib, OSI.930, imatinib, dasatinib, pazopanib, tandutinib, KI.8751, masitinib, vatalanib",0.75448733218585,0.228412519118745,FALSE +"HCC78","Pearson.est","MDM inhibitor",0.457,1.39,0.0994,789,0.582,"idasanutlin, RITA, serdemetan, AMG.232, nutlin.3, CGM097",1.00261361560269,0.235077015350112,FALSE +"HCC78","Pearson.est","MEK inhibitor",-0.3888,-0.926,0.576,1322,0.766,"arctigenin, trametinib, cobimetinib, nobiletin",0.239577516576788,0.115771230367396,FALSE +"HCC78","Pearson.est","MET inhibitor",-0.62142,-1.48,0.0505,1033,0.953,"LY2801653, AMG458, NVP.BVU972, INC.280, PHA.665752",1.29670862188134,0.0209070993616736,FALSE +"HCC78","Pearson.est","microtubule inhibitor",-0.46391,-1.12,0.335,963,0.749,"cabazitaxel, secnidazole, cytochalasin.b, D.64131",0.474955192963155,0.125518182300534,FALSE +"HCC78","Pearson.est","mTOR inhibitor",0.34814,1.04,0.437,99,0.713,"torin.1, PP242, SB.2343, sirolimus, WAY.600, PKI.179, PF.05212384",0.359518563029578,0.146910470148134,FALSE +"HCC78","Pearson.est","NFkB pathway inhibitor",-0.56902,-1.38,0.0972,1426,0.571,"bortezomib, Ro.106.9920, betulinic.acid",1.01233373507373,0.243363891754152,FALSE +"HCC78","Pearson.est","opioid receptor agonist",-0.56559,-1.36,0.112,1156,0.508,"salvinorin.a, trimebutine",0.950781977329818,0.294136287716081,FALSE +"HCC78","Pearson.est","p38 MAPK inhibitor",-0.45068,-1.09,0.345,1010,0.689,"VX.702, skepinone.l, SB.239063",0.462180904926726,0.161780778092374,FALSE +"HCC78","Pearson.est","PARP inhibitor",-0.49192,-1.17,0.26,841,0.694,"AZD2461, niraparib, olaparib, PJ.34, talazoparib",0.585026652029182,0.158640529545145,FALSE +"HCC78","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.44687,-1.09,0.36,912,0.689,"telatinib, motesanib, regorafenib, sunitinib, imatinib, dasatinib, pazopanib, crenolanib, tandutinib, ponatinib, KI.8751, masitinib, nintedanib, vatalanib, CP.673451",0.443697499232713,0.161780778092374,FALSE +"HCC78","Pearson.est","phosphatase inhibitor",0.26634,0.796,0.653,1065,0.823,"bis.maltolato.oxovanadium.IV., mycophenolate.mofetil, sodium.stibogluconate, mycophenolic.acid, GSK2830371, alexidine, BVT.948, AS.1949490, menadione, CID.5458317",0.185086818724926,0.0846001647877302,FALSE +"HCC78","Pearson.est","phosphodiesterase inhibitor",-0.43414,-1.05,0.394,1253,0.673,"EMD.53998, trequinsin, GSK256066",0.404503778174426,0.171984935776023,FALSE +"HCC78","Pearson.est","PI3K inhibitor",-0.19103,-0.464,0.986,874,1,"CH5132799, ZSTK.474, GSK2126458, taselisib, alpelisib, buparlisib, TG100.115, PIK.75, LY303511, TG.100713",0.0061230850587888,0,FALSE +"HCC78","Pearson.est","PLK inhibitor",-0.60771,-1.47,0.0604,1051,0.814,"NMS.1286937, GSK461364, BI.2536, GW.843682X, volasertib",1.21896306137887,0.0893755951107988,FALSE +"HCC78","Pearson.est","potassium channel blocker",-0.47012,-1.13,0.328,1381,0.75,"mepivacaine",0.484126156288321,0.1249387366083,FALSE +"HCC78","Pearson.est","PPAR receptor agonist",0.38625,1.15,0.252,10,0.674,"pterostilbene",0.598599459218456,0.17134010346468,FALSE +"HCC78","Pearson.est","progesterone receptor agonist",0.47657,1.48,0.0676,164,0.628,"levonorgestrel, norethindrone, norgestrel, norethindrone.acetate, tanaproget",1.17005330405836,0.202040356262804,FALSE +"HCC78","Pearson.est","proteasome inhibitor",-0.446,-1.07,0.387,1155,0.68,"ixazomib, carfilzomib, bortezomib",0.412289034981089,0.167491087293764,FALSE +"HCC78","Pearson.est","protein synthesis inhibitor",0.27161,0.829,0.607,129,0.838,"clofoctol, chloramphenicol.palmitate, methacycline, cycloheximide",0.216811308924742,0.0767559813697235,FALSE +"HCC78","Pearson.est","protein tyrosine kinase inhibitor",-0.45515,-1.09,0.364,877,0.689,"tyrphostin.A9, CP.724714, rheochrysidin, NVP.TAE226, BMS.599626",0.438898616350944,0.161780778092374,FALSE +"HCC78","Pearson.est","RAF inhibitor",-0.51102,-1.23,0.198,856,0.64,"sorafenib, LGX818, AZ.628, regorafenib, CEP.32496, PLX.4720, dabrafenib, TAK.632, GDC.0879, RAF265",0.703334809738469,0.193820026016113,FALSE +"HCC78","Pearson.est","RET tyrosine kinase inhibitor",-0.53745,-1.29,0.144,775,0.634,"apatinib, sorafenib, regorafenib, sunitinib, vandetanib, cabozantinib",0.84163750790475,0.197910742118267,FALSE +"HCC78","Pearson.est","retinoid receptor agonist",0.29019,0.832,0.66,225,0.909,"adapalene, bexarotene, fenretinide, LE.135",0.180456064458131,0.0414361167780325,FALSE +"HCC78","Pearson.est","ribonucleotide reductase inhibitor",-0.33296,-0.796,0.751,523,0.877,"triapine, gemcitabine, LY2334737, cladribine, fludarabine.phosphate, pentostatin, hydroxyurea, fludarabine, clofarabine",0.124360062995832,0.0570004066339595,FALSE +"HCC78","Pearson.est","serotonin receptor agonist",-0.35272,-0.85,0.698,1377,0.824,"ipsapirone",0.156144577376839,0.0840727883028842,FALSE +"HCC78","Pearson.est","serotonin receptor antagonist",-0.39145,-0.957,0.533,1038,0.783,"ziprasidone, paliperidone, SB.216641, SB.228357, RS.16566",0.273272790973428,0.106238237942057,FALSE +"HCC78","Pearson.est","sodium channel blocker",-0.44199,-1.06,0.391,991,0.685,"oxcarbazepine, triamterene, butamben, lappaconite, ajmaline, mepivacaine, quinidine",0.407823242604133,0.164309428507574,FALSE +"HCC78","Pearson.est","src inhibitor",-0.61449,-1.48,0.0641,1025,0.953,"PP.2, dasatinib, saracatinib, bosutinib, masitinib, TG.100572, PP.1",1.19314197048118,0.0209070993616736,FALSE +"HCC78","Pearson.est","sterol demethylase inhibitor",0.53762,1.6,0.06,201,0.789,"terconazole, sulconazole, lanoconazole, ketoconazole",1.22184874961636,0.10292299679058,FALSE +"HCC78","Pearson.est","TGF beta receptor inhibitor",-0.46705,-1.11,0.339,776,0.75,"SB.431542, LY2109761, repsox, D.4476",0.469800301796918,0.1249387366083,FALSE +"HCC78","Pearson.est","thymidylate synthase inhibitor",-0.52453,-1.27,0.181,807,0.591,"doxifluridine, carmofur, capecitabine, raltitrexed, trifluridine",0.742321425130815,0.228412519118745,FALSE +"HCC78","Pearson.est","topoisomerase inhibitor",-0.3689,-0.878,0.658,907,0.822,"rubitecan, valrubicin, etoposide.phosphate, genz.644282, amonafide, topotecan, fleroxacin, irinotecan, SN.38, exatecan.mesylate, etoposide, licochalcone.a, daunorubicin",0.181774106386044,0.0851281824599496,FALSE +"HCC78","Pearson.est","tubulin polymerization inhibitor",-0.19751,-0.473,0.988,772,1,"vindesine, combretastatin.A.4, epothilone.b, parbendazole, flubendazole, albendazole, fosbretabulin, docetaxel, paclitaxel",0.00524305541237188,0,FALSE +"HCC78","Pearson.est","tyrosine kinase inhibitor",-0.39783,-0.951,0.538,856,0.779,"sorafenib, UNC2250, tyrphostin.A9, regorafenib, sunitinib, CP.724714, dasatinib, rheochrysidin, vandetanib, cabozantinib, aminopurvalanol.a, hypericin, NVP.TAE226, tivantinib, BMS.599626",0.269217724333611,0.108462542327436,FALSE +"HCC78","Pearson.est","VEGFR inhibitor",-0.4503,-1.09,0.344,912,0.689,"telatinib, motesanib, regorafenib, sunitinib, OSI.930, XL.647, PD.173074, pazopanib, tivozanib, vandetanib, cabozantinib, KI.8751, ENMD.2076, MK.2461, lucitanib, nintedanib, RAF265, vatalanib, TG.100572, golvatinib, foretinib",0.46344155742847,0.161780778092374,FALSE +"HCC78","Pearson.est","vitamin D receptor agonist",-0.45799,-1.08,0.366,1144,0.693,"alfacalcidol, tacalcitol",0.436518914605589,0.159266765388193,FALSE +"H2126","Pearson.est","EGFR inhibitor",0.36732,0.877,0.632,615,0.949,"BMS.599626, BIBU.1361, BMS.690514, CUDC.101, dovitinib, CGP.52411, brigatinib, CP.724714, rociletinib, XL.647, vandetanib, tyrphostin.AG.494, salvianolic.acid.B, AZD8931, tucatinib, afatinib, osimertinib, AEE788, PD.153035, neratinib, dacomitinib, OSI.420, TAK.285",0.199282921717615,0.0227337875727074,FALSE +"H2126","Pearson.est","Abl kinase inhibitor",0.6241,1.48,0.0778,381,0.312,"GZD824, flumatinib, bafetinib, KW.2449, dasatinib, nilotinib, metatinib, ponatinib",1.10902040301031,0.505845405981557,FALSE +"H2126","Pearson.est","acetylcholine receptor agonist",0.35207,0.844,0.656,104,0.946,"tremorine",0.18309616062434,0.0241088635982073,FALSE +"H2126","Pearson.est","acetylcholine receptor antagonist",0.48713,1.16,0.286,685,0.814,"dicycloverine, darifenacin, iododexetimide, methscopolamine",0.543633966870957,0.0893755951107988,FALSE +"H2126","Pearson.est","adenosine receptor antagonist",-0.40061,-1.11,0.326,1389,0.617,"istradefylline, theophylline",0.486782399932061,0.209714835966758,FALSE +"H2126","Pearson.est","adrenergic receptor agonist",0.52509,1.27,0.197,433,0.631,"oxymetazoline, buphenine, clenbuterol, metaraminol, epinephrine, isoetharine, xylazine",0.705533773838407,0.199970640755866,FALSE +"H2126","Pearson.est","adrenergic receptor antagonist",0.33374,0.798,0.709,492,0.969,"atenolol...., propranolol, practolol, dronedarone, RS.17053, pindolol, carvedilol, atipamezole",0.149353764816933,0.0136762229492347,FALSE +"H2126","Pearson.est","AKT inhibitor",0.29672,0.728,0.804,414,1,"CCT128930, uprosertib, GDC.0068, palomid.529",0.0947439512515487,0,FALSE +"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.54476,1.3,0.178,458,0.619,"DMH1, CEP.37440, SB.505124, NVP.TAE684, AZD3463, brigatinib, GW.788388",0.749579997691106,0.208309350979882,FALSE +"H2126","Pearson.est","androgen receptor antagonist",0.44416,1.08,0.356,229,0.73,"cyproterone.acetate, flutamide",0.448550002027125,0.136677139879544,FALSE +"H2126","Pearson.est","antioxidant",0.27076,0.64,0.896,340,1,"mesna, benfotiamine",0.0476919903378748,0,FALSE +"H2126","Pearson.est","AP inhibitor",-0.55743,-1.52,0.0921,1274,0.503,"birinapant, embelin",1.03574036980315,0.298432014944073,FALSE +"H2126","Pearson.est","ATPase inhibitor",0.29333,0.719,0.8,400,0.977,"thonzonium, evodiamine, blebbistatin...., NMS.873",0.0969100130080564,0.0101054362812269,FALSE +"H2126","Pearson.est","Aurora kinase inhibitor",0.16615,0.405,0.996,716,0.997,"KW.2449, CCT137690, alisertib, ZM.447439, ENMD.2076, SNS.314, CCT129202, danusertib, MK.5108, tozasertib, barasertib, AT.9283, barasertib.HQPA",0.00174066157630127,0.00130484168834428,FALSE +"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.64834,1.57,0.0364,293,0.274,"tedizolid, azalomycin.b, josamycin, dirithromycin",1.43889861635094,0.562249437179612,FALSE +"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.33783,0.812,0.694,371,0.965,"sparfloxacin, sarafloxacin, novobiocin, trovafloxacin",0.158640529545145,0.0154726866562074,FALSE +"H2126","Pearson.est","BCL inhibitor",0.46583,1.12,0.332,260,0.79,"oridonin, navitoclax, gossypol, ABT.737",0.478861916295964,0.102372908709559,FALSE +"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.64612,1.57,0.0493,381,0.274,"GZD824, flumatinib, bafetinib, dasatinib, nilotinib, metatinib, ponatinib",1.30715308072277,0.562249437179612,FALSE +"H2126","Pearson.est","benzodiazepine receptor agonist",0.27708,0.672,0.839,9,1,"ZK.93423",0.0762380391712997,0,FALSE +"H2126","Pearson.est","bromodomain inhibitor",0.55749,1.34,0.158,557,0.551,"JQ1...., PFI.1, I.BET151, I.BET.762, OTX015",0.801342913045577,0.258848401148215,FALSE +"H2126","Pearson.est","calcium channel blocker",0.44482,1.07,0.377,186,0.729,"penfluridol, SKF.96365, efonidipine.monoethanolate",0.423658649794207,0.137272471682025,FALSE +"H2126","Pearson.est","CC chemokine receptor antagonist",0.67789,1.61,0.0249,273,0.302,"UNBS.5162, SB.225002, RS.504393, PF.04136309",1.60380065290426,0.519993057042849,FALSE +"H2126","Pearson.est","CDK inhibitor",0.38288,0.899,0.588,549,0.951,"JNJ.7706621, AZD5438, BMS.387032, PHA.848125, kenpaullone, palbociclib, abemaciclib, ribociclib, indisulam, PHA.793887, R547",0.230622673923862,0.0218194830625861,FALSE +"H2126","Pearson.est","CHK inhibitor",-0.74766,-2.05,0.0102,1334,0.1,"SCH.900776, AZD7762, CHIR.124, LY2603618",1.99139982823808,1,TRUE +"H2126","Pearson.est","cyclooxygenase inhibitor",0.30835,0.742,0.816,387,1,"phenazone, ramifenazone, piroxicam, aspirin, phenylbutazone, curcumin, suxibuzone",0.0883098412461389,0,FALSE +"H2126","Pearson.est","cytochrome P450 inhibitor",0.49505,1.19,0.262,361,0.771,"morin, itraconazole, clotrimazole, eplerenone",0.581698708680255,0.112945621949043,FALSE +"H2126","Pearson.est","DNA alkylating agent",0.36017,0.874,0.626,245,0.933,"estramustine, carmustine, TH.302",0.20342566678957,0.0301183562535,FALSE +"H2126","Pearson.est","DNA inhibitor",0.4437,1.08,0.365,251,0.73,"carmustine, oxaliplatin, mechlorethamine, primaquine",0.437707135543525,0.136677139879544,FALSE +"H2126","Pearson.est","DNA methyltransferase inhibitor",0.45846,1.11,0.324,321,0.76,"SGI.1027, decitabine, fdcyd",0.489454989793388,0.119186407719209,FALSE +"H2126","Pearson.est","DNA polymerase inhibitor",-0.34344,-0.961,0.478,1413,0.603,"cidofovir",0.320572103387881,0.219682687859849,FALSE +"H2126","Pearson.est","DNA synthesis inhibitor",-0.39245,-1.06,0.34,1153,0.642,"artesunate, enocitabine, anisomycin, altretamine",0.468521082957745,0.192464971931147,FALSE +"H2126","Pearson.est","dopamine receptor antagonist",-0.2781,-0.758,0.752,1198,0.748,"thioproperazine, acetophenazine, piperacetazine, raclopride, oxiperomide, remoxipride",0.123782159408358,0.126098402135539,FALSE +"H2126","Pearson.est","estrogen receptor agonist",-0.51476,-1.44,0.107,1327,0.399,"equol, PPT, levonorgestrel",0.97061622231479,0.399027104313252,FALSE +"H2126","Pearson.est","estrogen receptor antagonist",-0.37431,-1,0.418,1428,0.634,"raloxifene",0.378823718224965,0.197910742118267,FALSE +"H2126","Pearson.est","FGFR inhibitor",0.62353,1.49,0.0698,306,0.315,"nintedanib, MK.2461, PD.173074, lucitanib, erdafitinib, dovitinib",1.15614457737684,0.501689446210399,FALSE +"H2126","Pearson.est","FLT3 inhibitor",0.4724,1.13,0.307,399,0.796,"tandutinib, gilteritinib, KW.2449, dovitinib, sunitinib, ponatinib, ENMD.2076",0.512861624522813,0.0990869322623309,FALSE +"H2126","Pearson.est","glucocorticoid receptor agonist",-0.45798,-1.24,0.212,1167,0.536,"methylprednisolone, dexamethasone.acetate, ciclesonide, deflazacort, difluprednate, fluorometholone, desonide, hydrocortisone",0.673664139071249,0.27083521030723,FALSE +"H2126","Pearson.est","glutamate receptor antagonist",0.48031,1.14,0.288,131,0.802,"JNJ.16259685, felbamate, kynurenic.acid, diazooxonorleucine",0.540607512240769,0.0958256317158365,FALSE +"H2126","Pearson.est","glycogen synthase kinase inhibitor",0.69629,1.67,0.0188,343,0.277,"GSK.3.inhibitor.IX, LY2090314, CHIR.98014, kenpaullone, CHIR.99021, tideglusib",1.72584215073632,0.557520230935551,FALSE +"H2126","Pearson.est","growth factor receptor inhibitor",0.64015,1.54,0.0575,353,0.302,"GSK1838705A, GSK1904529A, PHA.848125, AZD3463",1.24033215531037,0.519993057042849,FALSE +"H2126","Pearson.est","HCV inhibitor",0.35746,0.88,0.599,172,0.966,"narlaprevir, daclatasvir",0.222573177610689,0.0150228735845067,FALSE +"H2126","Pearson.est","HDAC inhibitor",-0.35084,-0.939,0.494,1264,0.597,"scriptaid, NSC.3852, ACY.1215, entinostat, JNJ.26481585, mocetinostat, tacedinaline",0.306273051076353,0.224025668870631,FALSE +"H2126","Pearson.est","histamine receptor antagonist",0.30079,0.724,0.804,504,0.989,"ICI.162846, ebastine, chloropyramine, cyproheptadine, nizatidine, BF2.649, lafutidine",0.0947439512515487,0.0048037084028206,FALSE +"H2126","Pearson.est","HMGCR inhibitor",-0.3597,-0.992,0.456,1109,0.598,"lovastatin, mevastatin, fluvastatin",0.341035157335565,0.223298816011589,FALSE +"H2126","Pearson.est","HSP inhibitor",0.22475,0.527,0.958,666,1,"SNX.5422, XL888, NMS.E973, guanidine, tanespimycin, NVP.AUY922, SNX.2112, KW.2478",0.0186344909214556,0,FALSE +"H2126","Pearson.est","JAK inhibitor",0.2379,0.577,0.937,767,1,"filgotinib, baricitinib, AZD1480, AZ960, CEP.33779, WHI.P154, pacritinib, ruxolitinib, tozasertib, AT.9283, TG.02, TG.101348, atiprimod",0.0282604091122217,0,FALSE +"H2126","Pearson.est","KIT inhibitor",0.45787,1.09,0.356,540,0.755,"masitinib, OSI.930, tandutinib, motesanib, dasatinib, sunitinib, pazopanib, imatinib, vatalanib",0.448550002027125,0.122053048370812,FALSE +"H2126","Pearson.est","MDM inhibitor",-0.54119,-1.48,0.0945,1319,0.431,"idasanutlin, RITA",1.02456819149074,0.365522729839268,FALSE +"H2126","Pearson.est","MEK inhibitor",0.38746,0.921,0.55,274,0.928,"cobimetinib, arctigenin, trametinib, AZD8330",0.259637310505756,0.0324520237811379,FALSE +"H2126","Pearson.est","MET inhibitor",0.79219,1.92,0.00141,289,0.118,"PHA.665752, INC.280, LY2801653, NVP.BVU972, AMG458",2.85078088734462,0.928117992693875,TRUE +"H2126","Pearson.est","microtubule inhibitor",0.24948,0.595,0.951,506,1,"vinflunine, cytochalasin.b, vinblastine, D.64131",0.0218194830625861,0,FALSE +"H2126","Pearson.est","mTOR inhibitor",-0.3029,-0.799,0.683,1136,0.732,"deforolimus, LY303511, LY3023414, PP242, PKI.179, sirolimus, SB.2343, PI.103, WAY.600, torin.1",0.165579296318467,0.135488918941608,FALSE +"H2126","Pearson.est","NFkB pathway inhibitor",0.43063,1.04,0.405,92,0.77,"Ro.106.9920, bortezomib, betulinic.acid",0.392544976785331,0.113509274827518,FALSE +"H2126","Pearson.est","opioid receptor agonist",0.32699,0.789,0.729,145,0.965,"trimebutine",0.137272471682025,0.0154726866562074,FALSE +"H2126","Pearson.est","p38 MAPK inhibitor",0.71829,1.72,0.00836,25,0.31,"skepinone.l, SB.239063",2.07779372256098,0.508638306165727,FALSE +"H2126","Pearson.est","PARP inhibitor",0.42992,1.03,0.425,1,0.769,"PJ.34",0.371611069949688,0.114073660198569,FALSE +"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.40073,0.951,0.518,540,0.889,"masitinib, nintedanib, tandutinib, CP.673451, motesanib, dovitinib, dasatinib, sunitinib, ponatinib, pazopanib, crenolanib, imatinib, vatalanib",0.285670240254767,0.0510982390297863,FALSE +"H2126","Pearson.est","phosphatase inhibitor",0.34014,0.828,0.675,238,0.956,"alexidine, sodium.stibogluconate, BVT.948",0.170696227168975,0.0195421077238999,FALSE +"H2126","Pearson.est","phosphodiesterase inhibitor",0.25902,0.615,0.912,552,1,"EMD.53998, enoximone, zardaverine, YM.976, trequinsin",0.0400051616715838,0,FALSE +"H2126","Pearson.est","PI3K inhibitor",0.29202,0.706,0.82,370,0.977,"buparlisib, CH5132799, PIK.75, GSK2126458, BGT226, PI.828, TG.100713, TG100.115, PF.04691502",0.0861861476162833,0.0101054362812269,FALSE +"H2126","Pearson.est","PLK inhibitor",0.65187,1.53,0.0532,431,0.271,"volasertib, GW.843682X, rigosertib, BI.2536",1.27408836770495,0.567030709125594,FALSE +"H2126","Pearson.est","potassium channel blocker",0.27607,0.655,0.879,463,1,"mepivacaine, ML133, dofetilide",0.0560111249262281,0,FALSE +"H2126","Pearson.est","PPAR receptor agonist",-0.36302,-1.04,0.383,1220,0.616,"clofibrate, fenofibrate, pterostilbene",0.416801226031377,0.210419287835575,FALSE +"H2126","Pearson.est","progesterone receptor agonist",-0.62574,-1.64,0.0692,1261,0.482,"norgestrel, norethindrone.acetate, levonorgestrel, norethindrone",1.15989390554324,0.31695296176115,FALSE +"H2126","Pearson.est","proteasome inhibitor",0.73338,1.76,0.00986,295,0.321,"bortezomib, oprozomib, carfilzomib, ixazomib, MG.132, ixazomib.citrate",2.00612308505879,0.493494967595128,FALSE +"H2126","Pearson.est","protein synthesis inhibitor",-0.43829,-1.16,0.278,1154,0.597,"emetine, brefeldin.a, harringtonine, homoharringtonine, chloramphenicol.palmitate, anguidine, bruceantin, cycloheximide",0.555955204081924,0.224025668870631,FALSE +"H2126","Pearson.est","protein tyrosine kinase inhibitor",0.3997,0.959,0.514,403,0.895,"BMS.599626, tyrphostin.A9, mubritinib, CP.724714",0.289036881004724,0.048176964684088,FALSE +"H2126","Pearson.est","RAF inhibitor",0.65824,1.57,0.0506,248,0.274,"LGX818, dabrafenib, GDC.0879, RAF265, SB.590885, PLX.4720",1.2958494831602,0.562249437179612,FALSE +"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.50705,1.24,0.222,440,0.673,"sunitinib, cabozantinib, vandetanib, apatinib",0.653647025549361,0.171984935776023,FALSE +"H2126","Pearson.est","retinoid receptor agonist",0.32386,0.775,0.732,565,0.969,"CD.437, AM.580, tamibarotene, fenretinide, adapalene",0.135488918941608,0.0136762229492347,FALSE +"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.21894,0.527,0.971,647,1,"cytarabine, triapine, hydroxyurea, LY2334737",0.0127807700919951,0,FALSE +"H2126","Pearson.est","serotonin receptor agonist",0.52638,1.27,0.192,620,0.631,"pardoprunox, ipsapirone, NAN.190, aripiprazole",0.71669877129645,0.199970640755866,FALSE +"H2126","Pearson.est","serotonin receptor antagonist",0.35608,0.859,0.648,659,0.939,"paliperidone, sertindole, lurasidone, SB.200646, ziprasidone, RS.16566, aripiprazole, lerisetron, pirenperone",0.188424994129407,0.0273344077338891,FALSE +"H2126","Pearson.est","sodium channel blocker",0.48395,1.15,0.303,589,0.808,"ajmaline, mepivacaine, lappaconite, quinidine, oxcarbazepine, benzocaine, benzethonium, brivaracetam, mexiletine",0.518557371497695,0.0925886392254138,FALSE +"H2126","Pearson.est","src inhibitor",0.62977,1.53,0.0632,320,0.271,"TG.100572, masitinib, PP.1, saracatinib, dasatinib",1.19928292171761,0.567030709125594,FALSE +"H2126","Pearson.est","sterol demethylase inhibitor",-0.49121,-1.32,0.155,1322,0.487,"lanoconazole, ketoconazole, terconazole",0.809668301829709,0.312471038785366,FALSE +"H2126","Pearson.est","TGF beta receptor inhibitor",0.68025,1.65,0.0263,162,0.264,"D.4476, LY2109761, repsox",1.58004425151024,0.578396073130169,FALSE +"H2126","Pearson.est","thymidylate synthase inhibitor",0.686,1.68,0.0159,146,0.32,"raltitrexed, trifluridine",1.79860287567955,0.494850021680094,FALSE +"H2126","Pearson.est","topoisomerase inhibitor",0.58211,1.37,0.127,84,0.507,"topotecan, SN.38, etoposide.phosphate, rubitecan, irinotecan, exatecan.mesylate",0.896196279044043,0.294992040666664,FALSE +"H2126","Pearson.est","tubulin polymerization inhibitor",0.21287,0.512,0.978,407,0.991,"flubendazole, parbendazole, docetaxel, paclitaxel, vindesine, fosbretabulin, albendazole, vinblastine",0.00966114521239857,0.00392634551472468,FALSE +"H2126","Pearson.est","tyrosine kinase inhibitor",0.46719,1.1,0.36,440,0.757,"BMS.599626, tivantinib, bafetinib, tyrphostin.A9, hypericin, dasatinib, mubritinib, sunitinib, cabozantinib, CP.724714, vandetanib, apatinib",0.443697499232713,0.120904120499927,FALSE +"H2126","Pearson.est","VEGFR inhibitor",0.46834,1.11,0.348,422,0.76,"TG.100572, foretinib, OSI.930, nintedanib, golvatinib, RAF265, MK.2461, PD.173074, BMS.690514, lucitanib, tivozanib, motesanib, dovitinib, sunitinib, cabozantinib, ENMD.2076, pazopanib, XL.647, vandetanib",0.458420756053419,0.119186407719209,FALSE +"H2126","Pearson.est","vitamin D receptor agonist",-0.29394,-0.806,0.713,1268,0.768,"doxercalciferol, paricalcitol",0.146910470148134,0.114638779968488,FALSE +"HCC827","Pearson.est","EGFR inhibitor",-0.23095,-0.564,0.949,745,1,"CP.724714, salvianolic.acid.B, erlotinib, gefitinib, osimertinib, dacomitinib, pelitinib, BIBU.1361, GW.583340, afatinib, CNX.2006, WZ.4002, icotinib, canertinib, BMS.599626, CGP.52411, tyrphostin.AG.1478, PD.153035, TAK.285, vandetanib, OSI.420, WZ8040, rociletinib",0.0227337875727074,0,FALSE +"HCC827","Pearson.est","Abl kinase inhibitor",-0.48707,-1.21,0.246,946,0.669,"nilotinib, flumatinib, ponatinib, GZD824, bosutinib, tozasertib, KW.2449",0.609064892896621,0.174573882232177,FALSE +"HCC827","Pearson.est","acetylcholine receptor agonist",-0.55002,-1.36,0.123,934,0.643,"tremorine, pilocarpine, nicotine",0.910094888560602,0.191789027075778,FALSE +"HCC827","Pearson.est","acetylcholine receptor antagonist",0.27341,0.773,0.722,155,1,"darifenacin, diphemanil",0.141462802430361,0,FALSE +"HCC827","Pearson.est","adenosine receptor antagonist",-0.23167,-0.585,0.933,959,1,"istradefylline, sulmazole, theophylline",0.0301183562535,0,FALSE +"HCC827","Pearson.est","adrenergic receptor agonist",-0.28126,-0.703,0.82,822,0.959,"xylazine, norepinephrine, terbutaline, midodrine, oxymetazoline, A61603, clenbuterol, epinephrine, isoetharine",0.0861861476162833,0.0181813928293364,FALSE +"HCC827","Pearson.est","adrenergic receptor antagonist",0.24584,0.702,0.822,87,0.979,"prazosin, practolol, atenolol....",0.0851281824599496,0.00921730819686218,FALSE +"HCC827","Pearson.est","AKT inhibitor",-0.32319,-0.807,0.705,898,0.95,"A.674563, palomid.529, uprosertib, AT7867, triciribine, CCT128930",0.151810883008601,0.0222763947111523,FALSE +"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.33063,0.938,0.531,47,0.962,"SB.505124, NVP.TAE684",0.274905478918531,0.0168249279621871,FALSE +"HCC827","Pearson.est","androgen receptor antagonist",-0.5701,-1.42,0.0851,907,0.644,"bicalutamide, nilutamide, flutamide, RU.58841",1.07007043991541,0.191114132640188,FALSE +"HCC827","Pearson.est","antioxidant",-0.59243,-1.48,0.0646,1086,0.611,"chlorogenic.acid, mesna, benfotiamine, taurine",1.18976748200492,0.213958789757446,FALSE +"HCC827","Pearson.est","AP inhibitor",0.50527,1.42,0.113,226,0.481,"birinapant, tanshinone.i",0.94692155651658,0.317854923626168,FALSE +"HCC827","Pearson.est","ATPase inhibitor",0.50108,1.43,0.133,270,0.699,"k.strophanthidin, NMS.873, rabeprazole, ouabain, evodiamine, oligomycin.a",0.876148359032914,0.155522824254319,FALSE +"HCC827","Pearson.est","Aurora kinase inhibitor",-0.61165,-1.53,0.0577,1063,0.542,"GSK1070916, ENMD.2076, AMG900, TAK.901, MK.5108, AT.9283, SNS.314, tozasertib, alisertib, MLN.8054, CYC116, KW.2449, PF.03814735, hesperadin",1.23882418684427,0.266000713461613,FALSE +"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.50555,-1.24,0.233,857,0.741,"tilmicosin, dirithromycin, valnemulin, tedizolid, azalomycin.b",0.632644078973981,0.130181792020672,FALSE +"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",-0.39058,-0.98,0.476,1268,0.829,"novobiocin, lomefloxacin",0.322393047279507,0.0814454694497265,FALSE +"HCC827","Pearson.est","BCL inhibitor",-0.44984,-1.12,0.325,768,0.678,"ABT.737, oridonin, navitoclax, gossypol, TW.37, HA14.1",0.488116639021126,0.168770306132937,FALSE +"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",-0.49307,-1.2,0.239,865,0.661,"dasatinib, nilotinib, flumatinib, ponatinib, GZD824, bosutinib, tozasertib",0.621602099051862,0.17979854051436,FALSE +"HCC827","Pearson.est","benzodiazepine receptor agonist",0.2726,0.78,0.705,361,1,"bentazepam, gamma.aminobutyric.acid, CL.218872, ZK.93423, indiplon, temazepam",0.151810883008601,0,FALSE +"HCC827","Pearson.est","bromodomain inhibitor",-0.61862,-1.56,0.0418,1191,0.903,"PFI.1, I.BET.762, JQ1...., bromosporine",1.37882371822496,0.0443122496864942,FALSE +"HCC827","Pearson.est","calcium channel blocker",0.33376,0.93,0.484,129,0.912,"carboxyamidotriazole, fendiline, efonidipine.monoethanolate",0.315154638355588,0.0400051616715838,FALSE +"HCC827","Pearson.est","CC chemokine receptor antagonist",-0.39536,-0.988,0.46,1162,0.837,"navarixin, RS.504393, MK.0812",0.337242168318426,0.07727454200674,FALSE +"HCC827","Pearson.est","CDK inhibitor",-0.51168,-1.27,0.196,941,0.753,"BMS.387032, indirubin, palbociclib, ribociclib, aminopurvalanol.a, alvocidib, P276.00, AT.7519, abemaciclib, JNJ.7706621, TG.02, kenpaullone, AZD5438, PHA.793887, BMS.265246",0.707743928643524,0.123205023799299,FALSE +"HCC827","Pearson.est","CHK inhibitor",-0.52056,-1.32,0.171,887,0.708,"SCH.900776, LY2603618, LY2606368, SB.218078, AZD7762",0.767003889607846,0.149966742310231,FALSE +"HCC827","Pearson.est","cyclooxygenase inhibitor",-0.32063,-0.794,0.707,1125,0.927,"suxibuzone, aspirin, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam",0.150580586203101,0.0329202658555029,FALSE +"HCC827","Pearson.est","cytochrome P450 inhibitor",0.33357,0.983,0.432,41,0.929,"morin",0.364516253185088,0.0319842860063582,FALSE +"HCC827","Pearson.est","DNA alkylating agent",-0.55893,-1.37,0.132,1072,0.669,"carboplatin, estramustine, cyclophosphamide, TH.302, melphalan, satraplatin, streptozotocin, cisplatin",0.87942606879415,0.174573882232177,FALSE +"HCC827","Pearson.est","DNA inhibitor",-0.29015,-0.725,0.795,1072,0.95,"carboplatin, chlorambucil, primaquine, melphalan, valrubicin, busulfan",0.0996328713435297,0.0222763947111523,FALSE +"HCC827","Pearson.est","DNA methyltransferase inhibitor",0.36584,1.05,0.373,169,0.922,"disulfiram, azacitidine",0.428291168191312,0.0352690789463706,FALSE +"HCC827","Pearson.est","DNA polymerase inhibitor",-0.4463,-1.11,0.325,1108,0.653,"trifluridine, idoxuridine, menadione",0.488116639021126,0.185086818724926,FALSE +"HCC827","Pearson.est","DNA synthesis inhibitor",-0.51491,-1.27,0.2,1317,0.753,"CB.10.277, cyclocytidine, cisplatin",0.698970004336019,0.123205023799299,FALSE +"HCC827","Pearson.est","dopamine receptor antagonist",-0.37007,-0.908,0.562,1351,0.853,"acetophenazine, piperacetazine, UH.232....",0.250263684430939,0.069050968832477,FALSE +"HCC827","Pearson.est","estrogen receptor agonist",-0.46072,-1.15,0.303,1242,0.639,"estradiol.cypionate, estradiol, PPT",0.518557371497695,0.1944991418416,FALSE +"HCC827","Pearson.est","estrogen receptor antagonist",-0.21067,-0.526,0.965,783,0.984,"tamoxifen, clomifene, fulvestrant, danazol",0.0154726866562074,0.00700490156865849,FALSE +"HCC827","Pearson.est","FGFR inhibitor",0.59119,1.68,0.0465,92,1,"erdafitinib, dovitinib, lenvatinib, PD.173074",1.33254704711005,0,FALSE +"HCC827","Pearson.est","FLT3 inhibitor",-0.38105,-0.926,0.556,984,0.864,"midostaurin, gilteritinib, ENMD.2076, ponatinib, pacritinib, TG.02, tozasertib, KW.2449, lestaurtinib",0.254925208417942,0.0634862575211067,FALSE +"HCC827","Pearson.est","glucocorticoid receptor agonist",0.37394,1.05,0.358,282,0.922,"hydrocortisone, triamcinolone.acetonide, piretanide, halcinonide, dexamethasone.acetate, desonide, fluticasone.propionate, betamethasone",0.446116973356126,0.0352690789463706,FALSE +"HCC827","Pearson.est","glutamate receptor antagonist",0.24815,0.687,0.844,122,0.953,"felbamate, kynurenic.acid, CGP.37849",0.073657553374345,0.0209070993616736,FALSE +"HCC827","Pearson.est","glycogen synthase kinase inhibitor",-0.56352,-1.39,0.115,1166,0.672,"LY2090314, tideglusib, AZD2858, GSK.3.inhibitor.IX, kenpaullone",0.939302159646388,0.172630726946175,FALSE +"HCC827","Pearson.est","growth factor receptor inhibitor",-0.6104,-1.54,0.0444,1251,0.763,"GSK1838705A, AZD3463, lestaurtinib",1.35261702988538,0.11747546204512,FALSE +"HCC827","Pearson.est","HCV inhibitor",0.50416,1.42,0.116,721,0.481,"PSI.7976, daclatasvir, embelin, narlaprevir, Ro.9187, mericitabine",0.935542010773082,0.317854923626168,FALSE +"HCC827","Pearson.est","HDAC inhibitor",-0.62836,-1.57,0.0445,1101,1,"PCI.24781, SB.939, panobinostat, entinostat, M.344, belinostat, mocetinostat, RG2833, romidepsin, trichostatin.a, resminostat, R306465, dacinostat, JNJ.26481585, givinostat, AR.42",1.35163998901907,0,FALSE +"HCC827","Pearson.est","histamine receptor antagonist",-0.34893,-0.867,0.632,1070,0.91,"ICI.162846, cimetidine, lafutidine, famotidine, terfenadine, tiotidine, BF2.649",0.199282921717615,0.0409586076789064,FALSE +"HCC827","Pearson.est","HMGCR inhibitor",-0.32705,-0.803,0.726,1058,0.935,"simvastatin, pitavastatin",0.139063379299906,0.0291883891274822,FALSE +"HCC827","Pearson.est","HSP inhibitor",-0.48128,-1.19,0.257,1016,0.657,"tanespimycin, SNX.5422, NVP.AUY922, BIIB021, ganetespib, VER.49009, XL888",0.590066876668705,0.182434630440219,FALSE +"HCC827","Pearson.est","JAK inhibitor",-0.65375,-1.65,0.029,1126,1,"PRT062070, AZ960, AT.9283, pacritinib, WHI.P154, TG.02, filgotinib, tozasertib, lestaurtinib",1.53760200210104,0,FALSE +"HCC827","Pearson.est","KIT inhibitor",-0.18875,-0.458,0.986,1439,0.989,"vatalanib",0.0061230850587888,0.0048037084028206,FALSE +"HCC827","Pearson.est","MDM inhibitor",-0.38806,-0.953,0.535,944,0.834,"idasanutlin, nutlin.3, CGM097, RITA",0.271646217978772,0.0788339493622613,FALSE +"HCC827","Pearson.est","MEK inhibitor",-0.59097,-1.46,0.079,1081,0.592,"PD.198306, PD.0325901, arctigenin, selumetinib, Ro.4987655, AZD8330, cobimetinib, TAK.733, BIX.02188, trametinib, PD.184352, refametinib, nobiletin",1.10237290870956,0.22767829327708,FALSE +"HCC827","Pearson.est","MET inhibitor",-0.5097,-1.25,0.207,1189,0.76,"PF.04217903, PHA.665752",0.684029654543082,0.119186407719209,FALSE +"HCC827","Pearson.est","microtubule inhibitor",-0.22482,-0.563,0.941,750,1,"colchicine, estramustine.phosphate, secnidazole, D.64131, cytochalasin.b",0.0264103765727431,0,FALSE +"HCC827","Pearson.est","mTOR inhibitor",0.54714,1.52,0.0769,183,0.68,"OSI.027, PF.05212384, PP242, PKI.179, torin.1, AZD2014, WYE.125132, WYE.354, temsirolimus, deforolimus, PF.04691502, ku.0063794, AZD8055, SB.2343",1.11407366019857,0.167491087293764,FALSE +"HCC827","Pearson.est","NFkB pathway inhibitor",-0.26566,-0.679,0.853,916,0.968,"BAY.11.7085, bortezomib, curcumin, BAY.11.7082, parthenolide, Ro.106.9920, betulinic.acid",0.069050968832477,0.0141246426916063,FALSE +"HCC827","Pearson.est","opioid receptor agonist",-0.37453,-0.92,0.557,1002,0.852,"BW.180C, trimebutine, salvinorin.a",0.254144804826271,0.0695604052332999,FALSE +"HCC827","Pearson.est","p38 MAPK inhibitor",-0.46645,-1.16,0.286,996,0.669,"skepinone.l, SB.239063, VX.702, CMPD.1",0.543633966870957,0.174573882232177,FALSE +"HCC827","Pearson.est","PARP inhibitor",-0.61997,-1.53,0.0689,1331,0.542,"olaparib, talazoparib",1.16178077809237,0.266000713461613,FALSE +"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.21553,-0.539,0.971,1361,1,"SU014813, CP.673451, vatalanib",0.0127807700919951,0,FALSE +"HCC827","Pearson.est","phosphatase inhibitor",0.24188,0.676,0.856,23,0.926,"sodium.stibogluconate",0.0675262353228468,0.0333890133180656,FALSE +"HCC827","Pearson.est","phosphodiesterase inhibitor",-0.32394,-0.819,0.711,1295,0.952,"YM.976, GSK256066",0.148130399270234,0.0213630516155257,FALSE +"HCC827","Pearson.est","PI3K inhibitor",0.29105,0.824,0.649,183,1,"BGT226, PF.05212384, PKI.179, PI.828, idelalisib, buparlisib, AZD6482, PF.04691502, SB.2343",0.187755303199631,0,FALSE +"HCC827","Pearson.est","PLK inhibitor",-0.42277,-1.04,0.434,938,0.775,"rigosertib, volasertib, GSK461364, BI.2536",0.362510270487489,0.11069829749369,FALSE +"HCC827","Pearson.est","potassium channel blocker",-0.31232,-0.768,0.739,1093,0.949,"ibutilide, meglitinide",0.131355561605174,0.0227337875727074,FALSE +"HCC827","Pearson.est","PPAR receptor agonist",0.57471,1.64,0.0656,59,0.649,"pterostilbene, GW.501516",1.18309616062434,0.187755303199631,FALSE +"HCC827","Pearson.est","progesterone receptor agonist",0.25843,0.74,0.767,243,0.966,"levonorgestrel, norethindrone",0.115204636051019,0.0150228735845067,FALSE +"HCC827","Pearson.est","proteasome inhibitor",-0.44057,-1.11,0.354,1155,0.653,"carfilzomib, ixazomib.citrate, ixazomib",0.450996737974212,0.185086818724926,FALSE +"HCC827","Pearson.est","protein synthesis inhibitor",0.26197,0.741,0.756,29,1,"clofoctol, methacycline",0.121478204498793,0,FALSE +"HCC827","Pearson.est","protein tyrosine kinase inhibitor",-0.34378,-0.843,0.693,970,0.931,"PP.121, BMS.599626, NVP.TAE226, rheochrysidin",0.159266765388193,0.0310503190186574,FALSE +"HCC827","Pearson.est","RAF inhibitor",0.21448,0.618,0.913,1140,0.949,"sorafenib, regorafenib, SB.590885, vemurafenib, RAF265, GDC.0879, dabrafenib, LGX818, PLX.4720, AZ.628, TAK.632, CEP.32496",0.039529222465701,0.0227337875727074,FALSE +"HCC827","Pearson.est","RET tyrosine kinase inhibitor",0.29287,0.831,0.652,256,1,"apatinib, sorafenib, regorafenib",0.18575240426808,0,FALSE +"HCC827","Pearson.est","retinoid receptor agonist",0.37372,1.01,0.424,182,0.941,"fenretinide, adapalene, bexarotene",0.372634143407267,0.0264103765727431,FALSE +"HCC827","Pearson.est","ribonucleotide reductase inhibitor",-0.49441,-1.22,0.239,1065,0.712,"gemcitabine, triapine, hydroxyurea, fludarabine, clofarabine",0.621602099051862,0.147520006363144,FALSE +"HCC827","Pearson.est","serotonin receptor agonist",-0.46731,-1.15,0.294,1446,0.639,"aripiprazole",0.531652669587843,0.1944991418416,FALSE +"HCC827","Pearson.est","serotonin receptor antagonist",-0.48162,-1.17,0.294,1444,0.675,"RS.16566, aripiprazole",0.531652669587843,0.170696227168975,FALSE +"HCC827","Pearson.est","sodium channel blocker",0.42014,1.18,0.254,163,0.9,"brivaracetam, benzocaine, cibenzoline, benzethonium, mexiletine",0.595166283380062,0.0457574905606751,FALSE +"HCC827","Pearson.est","src inhibitor",-0.47998,-1.21,0.245,1028,0.669,"KX2.391, PP.1, bosutinib, PP.2",0.610833915635468,0.174573882232177,FALSE +"HCC827","Pearson.est","sterol demethylase inhibitor",0.39016,1.12,0.271,66,0.94,"chlormidazole",0.567030709125594,0.0268721464003014,FALSE +"HCC827","Pearson.est","TGF beta receptor inhibitor",-0.29199,-0.726,0.795,1355,0.968,"D.4476",0.0996328713435297,0.0141246426916063,FALSE +"HCC827","Pearson.est","thymidylate synthase inhibitor",-0.38363,-0.972,0.494,1102,0.821,"raltitrexed, trifluridine",0.306273051076353,0.0856568428805592,FALSE +"HCC827","Pearson.est","topoisomerase inhibitor",-0.50293,-1.23,0.219,978,0.724,"etoposide, teniposide, rubitecan, irinotecan, exatecan.mesylate, voreloxin, camptothecin, daunorubicin, TAS.103, valrubicin, amonafide, genz.644282, beta.lapachone, licochalcone.a",0.659555885159882,0.140261433802853,FALSE +"HCC827","Pearson.est","tubulin polymerization inhibitor",-0.21626,-0.537,0.954,1021,0.996,"paclitaxel, KX2.391, epothilone.b, combretastatin.A.4, docetaxel, fosbretabulin, epothilone.d",0.0204516252959049,0.00174066157630127,FALSE +"HCC827","Pearson.est","tyrosine kinase inhibitor",-0.30577,-0.747,0.775,1214,0.959,"AMG.208, NVP.TAE226, rheochrysidin, vandetanib, tyrphostin.AG.99, UNC2250",0.11069829749369,0.0181813928293364,FALSE +"HCC827","Pearson.est","VEGFR inhibitor",0.19972,0.57,0.962,92,0.949,"dovitinib, linifanib, lenvatinib, pazopanib, PD.173074",0.0168249279621871,0.0227337875727074,FALSE +"HCC827","Pearson.est","vitamin D receptor agonist",-0.41479,-1.03,0.421,825,0.771,"doxercalciferol, ercalcitriol, calcitriol, alfacalcidol, tacalcitol",0.375717904164332,0.112945621949043,FALSE +"CALU3","Pearson.est","EGFR inhibitor",-0.14573,-0.378,1,1143,0.999,"osimertinib, vandetanib, AEE788, TAK.285, brigatinib, PD.153035, BMS.599626",0,0.000434511774017692,FALSE +"CALU3","Pearson.est","Abl kinase inhibitor",-0.68891,-1.76,0.0214,1117,0.337,"imatinib, bafetinib, KW.2449, tozasertib, flumatinib, metatinib, ponatinib, dasatinib, GZD824",1.66958622665081,0.472370099128661,FALSE +"CALU3","Pearson.est","acetylcholine receptor agonist",0.47265,1.22,0.228,287,0.589,"pilocarpine, nefiracetam, oxiracetam",0.642065152999546,0.229884705212898,FALSE +"CALU3","Pearson.est","acetylcholine receptor antagonist",0.3678,0.971,0.477,48,0.698,"diphemanil",0.321481620959886,0.156144577376839,FALSE +"CALU3","Pearson.est","adenosine receptor antagonist",0.23774,0.615,0.898,87,0.935,"SCH.58261",0.0467236633326956,0.0291883891274822,FALSE +"CALU3","Pearson.est","adrenergic receptor agonist",-0.35046,-0.898,0.572,1176,0.748,"isoxsuprine, clenbuterol, A61603, terbutaline, buphenine, metaraminol",0.242603971206976,0.126098402135539,FALSE +"CALU3","Pearson.est","adrenergic receptor antagonist",0.30278,0.786,0.664,215,0.875,"prazosin, oxprenolol, RS.17053, atenolol......",0.177831920631982,0.0579919469776868,FALSE +"CALU3","Pearson.est","AKT inhibitor",0.29058,0.79,0.713,306,0.906,"GSK2110183, ONC201, GDC.0068",0.146910470148134,0.0428718023231869,FALSE +"CALU3","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.51178,-1.3,0.163,1257,0.543,"AP26113, brigatinib, CEP.37440, DMH1",0.787812395596042,0.265200170411153,FALSE +"CALU3","Pearson.est","androgen receptor antagonist",0.56923,1.52,0.101,289,0.426,"nilutamide, enzalutamide, bicalutamide",0.995678626217357,0.370590400897281,FALSE +"CALU3","Pearson.est","antioxidant",-0.5742,-1.48,0.0881,828,0.535,"taurine, trolox, chlorogenic.acid, benfotiamine, rutin, mesna",1.05502409158795,0.271646217978772,FALSE +"CALU3","Pearson.est","AP inhibitor",-0.20917,-0.528,0.969,1214,1,"LCL.161",0.0136762229492347,0,FALSE +"CALU3","Pearson.est","ATPase inhibitor",0.52688,1.41,0.108,65,0.423,"k.strophanthidin, rabeprazole, digitoxin",0.96657624451305,0.373659632624958,FALSE +"CALU3","Pearson.est","Aurora kinase inhibitor",-0.39399,-1.02,0.425,889,0.62,"MLN.8054, aurora.a.inhibitor.i, CYC116, PF.03814735, barasertib, ZM.447439, AT.9283, ENMD.2076, SNS.314, TAK.901, KW.2449, tozasertib, hesperadin, alisertib",0.371611069949688,0.207608310501746,FALSE +"CALU3","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.4274,-1.1,0.345,923,0.581,"valnemulin, josamycin, azalomycin.b, dirithromycin, tedizolid",0.462180904926726,0.235823867609669,FALSE +"CALU3","Pearson.est","bacterial DNA gyrase inhibitor",0.36674,0.973,0.456,68,0.731,"norfloxacin, finafloxacin",0.341035157335565,0.13608262304214,FALSE +"CALU3","Pearson.est","BCL inhibitor",-0.54771,-1.41,0.143,1110,0.497,"ABT.737, gossypol, navitoclax",0.844663962534938,0.303643611266668,FALSE +"CALU3","Pearson.est","Bcr.Abl kinase inhibitor",-0.6912,-1.79,0.0153,1117,0.407,"imatinib, bafetinib, tozasertib, flumatinib, metatinib, ponatinib, dasatinib, GZD824",1.8153085691824,0.39040559077478,FALSE +"CALU3","Pearson.est","benzodiazepine receptor agonist",0.40884,1.06,0.382,319,0.653,"bentazepam, nefiracetam, gamma.aminobutyric.acid, piperazine, eprinomectin",0.417936637088291,0.185086818724926,FALSE +"CALU3","Pearson.est","bromodomain inhibitor",-0.46012,-1.16,0.301,1156,0.56,"bromosporine, PFI.1",0.521433504406157,0.2518119729938,FALSE +"CALU3","Pearson.est","calcium channel blocker",-0.42031,-1.07,0.361,1289,0.594,"SKF.96365, penfluridol",0.442492798094342,0.226213555018806,FALSE +"CALU3","Pearson.est","CC chemokine receptor antagonist",-0.46387,-1.18,0.268,1099,0.619,"navarixin, UNBS.5162, MK.0812, RS.504393",0.571865205971211,0.208309350979882,FALSE +"CALU3","Pearson.est","CDK inhibitor",-0.53651,-1.37,0.133,949,0.504,"PHA.848125, TG.02, alvocidib, R547, kenpaullone, dinaciclib, BMS.265246, P276.00, AT.7519, JNJ.7706621, palbociclib, ribociclib, AZD5438, abemaciclib",0.876148359032914,0.297569463554475,FALSE +"CALU3","Pearson.est","CHK inhibitor",-0.5801,-1.53,0.0787,910,0.542,"AZD7762, CHIR.124, SCH.900776, LY2606368, SB.218078",1.10402526764094,0.266000713461613,FALSE +"CALU3","Pearson.est","cyclooxygenase inhibitor",0.27583,0.733,0.767,161,0.856,"pterostilbene, naproxen, aspirin, AM.404",0.115204636051019,0.0675262353228468,FALSE +"CALU3","Pearson.est","cytochrome P450 inhibitor",-0.43168,-1.1,0.349,1435,0.581,"itraconazole",0.45717457304082,0.235823867609669,FALSE +"CALU3","Pearson.est","DNA alkylating agent",-0.30849,-0.791,0.702,1081,0.891,"streptozotocin, TH.302, cisplatin, dianhydrogalactitol, estramustine, carmustine",0.153662887870195,0.0501222959631252,FALSE +"CALU3","Pearson.est","DNA inhibitor",0.297,0.799,0.68,421,0.931,"mechlorethamine, tirapazamine, carboplatin, metronidazole, teroxirone, nithiamide, bendamustine, busulfan, melphalan, nimorazole",0.167491087293764,0.0310503190186574,FALSE +"CALU3","Pearson.est","DNA methyltransferase inhibitor",-0.49186,-1.24,0.22,887,0.591,"RG108, fdcyd, azacitidine, SGI.1027, decitabine",0.657577319177794,0.228412519118745,FALSE +"CALU3","Pearson.est","DNA polymerase inhibitor",0.31569,0.834,0.654,303,0.909,"famciclovir, cidofovir, cephalomannine",0.184422251675733,0.0414361167780325,FALSE +"CALU3","Pearson.est","DNA synthesis inhibitor",0.19162,0.507,0.976,330,0.977,"artemisinin, artesunate, altretamine, nelarabine",0.0105501823333082,0.0101054362812269,FALSE +"CALU3","Pearson.est","dopamine receptor antagonist",0.55479,1.49,0.102,119,0.361,"remoxipride, thioproperazine, raclopride, oxiperomide",0.991399828238082,0.442492798094342,FALSE +"CALU3","Pearson.est","estrogen receptor agonist",0.4407,1.15,0.277,189,0.576,"levonorgestrel, erteberel, ethinyl.estradiol",0.557520230935551,0.239577516576788,FALSE +"CALU3","Pearson.est","estrogen receptor antagonist",-0.37184,-0.937,0.523,1140,0.721,"fulvestrant, tamoxifen, danazol",0.281498311132726,0.142064735280571,FALSE +"CALU3","Pearson.est","FGFR inhibitor",-0.42017,-1.08,0.354,1366,0.595,"nintedanib, MK.2461",0.450996737974212,0.22548303427145,FALSE +"CALU3","Pearson.est","FLT3 inhibitor",-0.45221,-1.15,0.301,1202,0.557,"midostaurin, pacritinib, gilteritinib, KW.2449, tozasertib, lestaurtinib, sunitinib, ponatinib",0.521433504406157,0.254144804826271,FALSE +"CALU3","Pearson.est","glucocorticoid receptor agonist",0.58182,1.52,0.0886,366,0.426,"hydrocortisone, prednisolone, desonide, ciclesonide, methylprednisolone, dexamethasone.acetate, triamcinolone.acetonide, halcinonide, fluticasone.propionate, piretanide, fludroxycortide, triamcinolone, difluprednate, betamethasone, deflazacort",1.05256627811295,0.370590400897281,FALSE +"CALU3","Pearson.est","glutamate receptor antagonist",0.28896,0.751,0.74,412,0.897,"tiletamine, latrepirdine, MTPG, CGP.37849, kynurenic.acid, ACDPP, IEM1754",0.130768280269024,0.0472075569559079,FALSE +"CALU3","Pearson.est","glycogen synthase kinase inhibitor",-0.46507,-1.17,0.274,935,0.587,"CHIR.98014, AZD2858, kenpaullone, tideglusib, GSK.3.inhibitor.IX, LY2090314",0.562249437179612,0.231361898752386,FALSE +"CALU3","Pearson.est","growth factor receptor inhibitor",-0.47615,-1.23,0.242,949,0.581,"PHA.848125, AZD3463, GSK1838705A, lestaurtinib",0.616184634019569,0.235823867609669,FALSE +"CALU3","Pearson.est","HCV inhibitor",0.44455,1.17,0.277,7,0.627,"PSI.7976",0.557520230935551,0.202732459169284,FALSE +"CALU3","Pearson.est","HDAC inhibitor",-0.456,-1.16,0.3,1123,0.56,"givinostat, PCI.24781, belinostat, trichostatin.a, entinostat, resminostat, dacinostat, JNJ.26481585, AR.42, M.344, R306465, RG2833",0.522878745280338,0.2518119729938,FALSE +"CALU3","Pearson.est","histamine receptor antagonist",0.24511,0.654,0.848,206,0.927,"ranitidine, epinastine, famotidine, terfenadine",0.0716041477432862,0.0329202658555029,FALSE +"CALU3","Pearson.est","HMGCR inhibitor",0.42545,1.16,0.282,22,0.6,"fluvastatin",0.549750891680639,0.221848749616356,FALSE +"CALU3","Pearson.est","HSP inhibitor",-0.52902,-1.35,0.16,1059,0.508,"alvespimycin, tanespimycin, SNX.2112, XL888, SNX.5422, ganetespib, VER.49009, NVP.AUY922",0.795880017344075,0.294136287716081,FALSE +"CALU3","Pearson.est","JAK inhibitor",-0.29549,-0.779,0.726,967,0.849,"TG.101209, TG.02, AZ960, AT.9283, PRT062070, baricitinib, pacritinib, tozasertib, lestaurtinib",0.139063379299906,0.0710923097560473,FALSE +"CALU3","Pearson.est","KIT inhibitor",-0.60997,-1.56,0.0696,1117,0.653,"imatinib, telatinib, midostaurin, motesanib, masitinib, pazopanib, vatalanib, sunitinib, dasatinib, KI.8751",1.15739076038944,0.185086818724926,FALSE +"CALU3","Pearson.est","MDM inhibitor",0.70735,1.84,0.0141,428,0.257,"idasanutlin, RITA, nutlin.3, serdemetan, CGM097, AMG.232",1.85078088734462,0.590066876668705,FALSE +"CALU3","Pearson.est","MEK inhibitor",-0.47941,-1.22,0.23,989,0.572,"refametinib, PD.184352, MEK162, BIX.02188, selumetinib, AS.703026, TAK.733, AZD8330, nobiletin, arctigenin, trametinib, cobimetinib",0.638272163982407,0.242603971206976,FALSE +"CALU3","Pearson.est","MET inhibitor",-0.80761,-2.05,0,1371,0.0949,"PHA.665752, LY2801653, INC.280, NVP.BVU972",Inf,1.02273378757271,TRUE +"CALU3","Pearson.est","microtubule inhibitor",-0.18774,-0.478,0.987,1356,1,"cytochalasin.b",0.00568284733036327,0,FALSE +"CALU3","Pearson.est","mTOR inhibitor",-0.29971,-0.763,0.737,1002,0.853,"WYE.354, AZD2014, MLN0128, deforolimus, GSK2126458, GDC.0980, NVP.BEZ235, torin.2, everolimus, temsirolimus",0.132532512140949,0.069050968832477,FALSE +"CALU3","Pearson.est","NFkB pathway inhibitor",-0.40412,-1.03,0.404,1346,0.622,"betulinic.acid, bortezomib, Ro.106.9920",0.393618634889395,0.206209615309181,FALSE +"CALU3","Pearson.est","opioid receptor agonist",-0.59869,-1.49,0.0909,1183,0.575,"trimebutine, cebranopadol",1.04143611677803,0.24033215531037,FALSE +"CALU3","Pearson.est","p38 MAPK inhibitor",0.39146,1.03,0.413,178,0.668,"talmapimod, SB.242235",0.384049948343599,0.175223537524454,FALSE +"CALU3","Pearson.est","PARP inhibitor",-0.29158,-0.738,0.785,1090,0.869,"olaparib, PJ.34, talazoparib",0.105130343254747,0.0609802235513335,FALSE +"CALU3","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.52178,-1.34,0.166,1117,0.496,"imatinib, telatinib, motesanib, masitinib, trapidil, CP.673451, nintedanib, pazopanib, vatalanib, sunitinib, ponatinib, dasatinib, KI.8751",0.779891911959945,0.304518323509803,FALSE +"CALU3","Pearson.est","phosphatase inhibitor",-0.22184,-0.568,0.955,319,0.999,"GSK2830371, bis.maltolato.oxovanadium.IV., mycophenolic.acid, mycophenolate.mofetil, CID.5458317, sodium.stibogluconate, AS.1949490, menadione, alexidine, BVT.948",0.0199966284162537,0.000434511774017692,FALSE +"CALU3","Pearson.est","phosphodiesterase inhibitor",-0.30659,-0.781,0.731,1160,0.866,"trequinsin, YM.976, EMD.53998",0.13608262304214,0.0624821079826534,FALSE +"CALU3","Pearson.est","PI3K inhibitor",-0.27093,-0.683,0.827,1037,0.925,"buparlisib, ZSTK.474, CH5132799, GSK2126458, GDC.0980, TG.100713, TG100.115, NVP.BEZ235, CUDC.907, PIK.75",0.0824944904474534,0.0338582672609674,FALSE +"CALU3","Pearson.est","PLK inhibitor",0.29422,0.748,0.769,231,0.867,"HMN.214, NMS.1286937",0.114073660198569,0.0619809025237897,FALSE +"CALU3","Pearson.est","potassium channel blocker",-0.46022,-1.17,0.296,1207,0.587,"dofetilide, mepivacaine",0.528708288941061,0.231361898752386,FALSE +"CALU3","Pearson.est","PPAR receptor agonist",0.58746,1.63,0.0439,9,0.392,"pterostilbene",1.35753547975788,0.406713932979543,FALSE +"CALU3","Pearson.est","progesterone receptor agonist",0.6618,1.75,0.0312,163,0.284,"norethindrone, levonorgestrel, norgestrel, dienogest, norethindrone.acetate",1.50584540598156,0.546681659952962,FALSE +"CALU3","Pearson.est","proteasome inhibitor",-0.56836,-1.41,0.135,1229,0.497,"ixazomib, carfilzomib, bortezomib",0.869666231504994,0.303643611266668,FALSE +"CALU3","Pearson.est","protein synthesis inhibitor",0.50482,1.29,0.167,144,0.511,"azomycin..2.nitroimidazole., chloramphenicol.palmitate, cycloheximide, clofoctol, tedizolid.phosphate, bruceantin",0.777283528852417,0.291579099865287,FALSE +"CALU3","Pearson.est","protein tyrosine kinase inhibitor",-0.40837,-1.04,0.402,1423,0.624,"BMS.599626",0.39577394691553,0.204815410317576,FALSE +"CALU3","Pearson.est","RAF inhibitor",-0.60857,-1.55,0.0486,948,0.572,"PLX.4720, sorafenib, vemurafenib, GDC.0879, SB.590885, TAK.632, RAF265, AZ.628, LGX818, dabrafenib",1.31336373073771,0.242603971206976,FALSE +"CALU3","Pearson.est","RET tyrosine kinase inhibitor",-0.54594,-1.37,0.134,939,0.504,"cabozantinib, sorafenib, vandetanib, sunitinib",0.872895201635192,0.297569463554475,FALSE +"CALU3","Pearson.est","retinoid receptor agonist",-0.25319,-0.651,0.881,1122,0.942,"AM.580, fenretinide, adarotene",0.0550240915879521,0.0259490972071227,FALSE +"CALU3","Pearson.est","ribonucleotide reductase inhibitor",-0.55843,-1.42,0.125,1147,0.564,"hydroxyurea, triapine, fludarabine, clofarabine",0.903089986991944,0.248720896016658,FALSE +"CALU3","Pearson.est","serotonin receptor agonist",0.77752,2.08,0.00691,1,0.0826,"aripiprazole",2.1605219526258,1.08301995267962,TRUE +"CALU3","Pearson.est","serotonin receptor antagonist",0.42718,1.11,0.31,1,0.605,"aripiprazole",0.508638306165727,0.218244625347531,FALSE +"CALU3","Pearson.est","sodium channel blocker",-0.30563,-0.782,0.717,981,0.885,"benzocaine, butamben, mexiletine, ajmaline, oxcarbazepine, quinidine, lappaconite, mepivacaine",0.1444808443322,0.0530567293021746,FALSE +"CALU3","Pearson.est","src inhibitor",-0.60455,-1.57,0.0661,1205,0.779,"masitinib, saracatinib, PP.1, dasatinib, TG.100572",1.17979854051436,0.108462542327436,FALSE +"CALU3","Pearson.est","sterol demethylase inhibitor",0.49854,1.36,0.131,321,0.451,"terconazole, lanoconazole, ketoconazole",0.882728704344236,0.345823458122039,FALSE +"CALU3","Pearson.est","TGF beta receptor inhibitor",-0.39864,-1,0.45,933,0.636,"LY2109761, SB.431542, repsox, D.4476",0.346787486224656,0.196542884351586,FALSE +"CALU3","Pearson.est","thymidylate synthase inhibitor",-0.43413,-1.11,0.339,1184,0.604,"raltitrexed, doxifluridine, trifluridine",0.469800301796918,0.218963061378868,FALSE +"CALU3","Pearson.est","topoisomerase inhibitor",-0.55942,-1.45,0.11,942,0.551,"nemorubicin, camptothecin, genz.644282, voreloxin, amonafide, exatecan.mesylate, fleroxacin, doxorubicin, licochalcone.a, topotecan, valrubicin, etoposide.phosphate, rubitecan, teniposide, SN.38, etoposide, daunorubicin, irinotecan",0.958607314841775,0.258848401148215,FALSE +"CALU3","Pearson.est","tubulin polymerization inhibitor",0.57638,1.49,0.111,219,0.361,"nocodazole, dolastatin.10, vinorelbine, taltobulin, BNC105, CYT.997, mebendazole, indibulin, KX2.391, ABT.751, vincristine, verubulin, vinblastine",0.954677021213343,0.442492798094342,FALSE +"CALU3","Pearson.est","tyrosine kinase inhibitor",-0.33975,-0.855,0.627,939,0.804,"cabozantinib, mubritinib, sorafenib, tyrphostin.AG.99, bafetinib, tivantinib, vandetanib, hypericin, sunitinib, dasatinib, BMS.599626",0.202732459169284,0.0947439512515487,FALSE +"CALU3","Pearson.est","VEGFR inhibitor",-0.50334,-1.26,0.198,1366,0.584,"nintedanib, pazopanib, tivozanib, vatalanib, sunitinib, KI.8751, MK.2461, golvatinib, TG.100572, foretinib",0.703334809738469,0.233587152887601,FALSE +"CALU3","Pearson.est","vitamin D receptor agonist",-0.34669,-0.904,0.548,790,0.756,"doxercalciferol, ercalcitriol, alfacalcidol, calcitriol, tacalcitol",0.261219441515631,0.121478204498793,FALSE +"H2009","Pearson.est","EGFR inhibitor",0.17971,0.505,0.992,108,0.983,"WZ.3146, BIBX.1382, CUDC.101, WZ.4002, CNX.2006",0.00348832784582135,0.00744648216786438,FALSE +"H2009","Pearson.est","Abl kinase inhibitor",-0.53111,-1.28,0.188,874,0.724,"metatinib, KW.2449, tozasertib, imatinib, nilotinib, flumatinib, bosutinib, ponatinib",0.72584215073632,0.140261433802853,FALSE +"H2009","Pearson.est","acetylcholine receptor agonist",-0.46759,-1.11,0.329,1141,0.693,"pilocarpine, nicotine",0.482804102050026,0.159266765388193,FALSE +"H2009","Pearson.est","acetylcholine receptor antagonist",-0.58871,-1.42,0.0966,911,0.601,"iododexetimide, darifenacin, hyoscyamine, dicycloverine, methscopolamine",1.01502287358451,0.22112552799726,FALSE +"H2009","Pearson.est","adenosine receptor antagonist",-0.52844,-1.28,0.156,1099,0.724,"istradefylline, sulmazole, PSB.1115",0.806875401645538,0.140261433802853,FALSE +"H2009","Pearson.est","adrenergic receptor agonist",-0.48395,-1.15,0.309,956,0.651,"ritodrine, metaraminol, isoxsuprine, epinephrine, buphenine, A61603, terbutaline, isoetharine, clenbuterol",0.510041520575165,0.186419011431808,FALSE +"H2009","Pearson.est","adrenergic receptor antagonist",-0.41894,-1.03,0.448,1003,0.724,"pindolol, levobunolol, idazoxan, metoprolol, atipamezole, atenolol...., dronedarone",0.348721986001856,0.140261433802853,FALSE +"H2009","Pearson.est","AKT inhibitor",-0.19235,-0.458,0.984,1107,1,"uprosertib, palomid.529",0.00700490156865849,0,FALSE +"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.25599,-0.63,0.916,1104,0.979,"GW.788388, CEP.37440, DMH1",0.0381045263321496,0.00921730819686218,FALSE +"H2009","Pearson.est","androgen receptor antagonist",-0.41524,-1.02,0.457,1108,0.725,"cyproterone.acetate, enzalutamide, flutamide",0.34008379993015,0.139661993429006,FALSE +"H2009","Pearson.est","antioxidant",-0.41149,-0.985,0.478,1122,0.758,"benfotiamine, taurine",0.320572103387881,0.120330794367946,FALSE +"H2009","Pearson.est","AP inhibitor",0.34323,0.963,0.423,313,0.741,"birinapant, tanshinone.i, embelin, idronoxil",0.373659632624958,0.130181792020672,FALSE +"H2009","Pearson.est","ATPase inhibitor",0.40152,1.1,0.317,11,0.746,"k.strophanthidin, rabeprazole",0.498940737782249,0.127261172527331,FALSE +"H2009","Pearson.est","Aurora kinase inhibitor",-0.19929,-0.475,0.99,850,1,"hesperadin, ZM.447439, KW.2449, tozasertib, MK.8745, SNS.314, CYC116, ENMD.2076, alisertib",0.00436480540245009,0,FALSE +"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.62109,-1.45,0.0812,933,0.639,"tilmicosin, josamycin, azalomycin.b, radezolid, tedizolid, dirithromycin",1.09044397075882,0.1944991418416,FALSE +"H2009","Pearson.est","bacterial DNA gyrase inhibitor",0.43069,1.19,0.253,59,0.648,"norfloxacin, finafloxacin, lomefloxacin",0.596879478824182,0.188424994129407,FALSE +"H2009","Pearson.est","BCL inhibitor",-0.34703,-0.854,0.675,1194,0.87,"ABT.737, navitoclax",0.170696227168975,0.0604807473813815,FALSE +"H2009","Pearson.est","Bcr.Abl kinase inhibitor",-0.53399,-1.27,0.194,874,0.71,"metatinib, tozasertib, imatinib, nilotinib, flumatinib, bosutinib, ponatinib",0.712198270069774,0.148741651280925,FALSE +"H2009","Pearson.est","benzodiazepine receptor agonist",0.28012,0.784,0.732,182,0.901,"eprinomectin, bentazepam, ivermectin, gamma.aminobutyric.acid",0.135488918941608,0.045275209020937,FALSE +"H2009","Pearson.est","bromodomain inhibitor",-0.7448,-1.83,0.00794,1074,0.277,"OTX015, PFI.1, I.BET.762, I.BET151, JQ1...., bromosporine",2.1001794975729,0.557520230935551,FALSE +"H2009","Pearson.est","calcium channel blocker",-0.26506,-0.638,0.905,1117,0.988,"tetrandrine, efonidipine.monoethanolate, SKF.96365",0.0433514207947967,0.00524305541237188,FALSE +"H2009","Pearson.est","CC chemokine receptor antagonist",-0.50911,-1.23,0.222,780,0.588,"UNBS.5162, SB.225002, PF.04136309, MK.0812, RS.504393",0.653647025549361,0.230622673923862,FALSE +"H2009","Pearson.est","CDK inhibitor",-0.50993,-1.24,0.208,971,0.646,"aminopurvalanol.a, JNJ.7706621, alvocidib, kenpaullone, AZD5438, indisulam, BMS.387032, palbociclib, PHA.793887, dinaciclib, ribociclib, TG.02, P276.00, AT.7519, abemaciclib",0.681936665037238,0.189767482004916,FALSE +"H2009","Pearson.est","CHK inhibitor",-0.49495,-1.18,0.261,838,0.63,"PF.477736, LY2606368, AZD7762, LY2603618, SB.218078",0.583359492661719,0.200659450546418,FALSE +"H2009","Pearson.est","cyclooxygenase inhibitor",-0.23569,-0.575,0.935,836,1,"piroxicam, acetylsalicylsalicylic.acid, phenazone, naproxen, phenylbutazone, ketoprofen, sulfasalazine, tryptanthrin, FR.122047, ramifenazone, indoprofen, suxibuzone",0.0291883891274822,0,FALSE +"H2009","Pearson.est","cytochrome P450 inhibitor",-0.51104,-1.23,0.208,1013,0.588,"clotrimazole, morin, PF.4981517, itraconazole",0.681936665037238,0.230622673923862,FALSE +"H2009","Pearson.est","DNA alkylating agent",-0.5237,-1.26,0.215,1144,0.698,"ifosfamide, streptozotocin, temozolomide, mitomycin.c, cisplatin, carmustine, estramustine",0.667561540084395,0.156144577376839,FALSE +"H2009","Pearson.est","DNA inhibitor",-0.31788,-0.774,0.75,1089,0.908,"bendamustine, busulfan, carmustine, pibenzimol, primaquine",0.1249387366083,0.0419141514789149,FALSE +"H2009","Pearson.est","DNA methyltransferase inhibitor",-0.52123,-1.24,0.237,944,0.646,"SGI.1027, fdcyd, decitabine, azacitidine",0.625251653989896,0.189767482004916,FALSE +"H2009","Pearson.est","DNA polymerase inhibitor",-0.30872,-0.751,0.784,1152,0.924,"idoxuridine, menadione, trifluridine",0.105683937315562,0.0343280287798933,FALSE +"H2009","Pearson.est","DNA synthesis inhibitor",-0.29743,-0.715,0.815,1224,0.955,"mitomycin.c, cisplatin, capecitabine",0.0888423912600234,0.0199966284162537,FALSE +"H2009","Pearson.est","dopamine receptor antagonist",-0.26798,-0.65,0.896,1088,0.994,"amisulpride, paliperidone, ziprasidone, mesoridazine, piperacetazine, lurasidone",0.0476919903378748,0.00261361560268669,FALSE +"H2009","Pearson.est","estrogen receptor agonist",-0.3681,-0.88,0.616,1017,0.844,"estradiol.cypionate, erteberel, PPT, estradiol",0.210419287835575,0.073657553374345,FALSE +"H2009","Pearson.est","estrogen receptor antagonist",-0.54696,-1.31,0.168,1048,0.781,"danazol, clomifene, tamoxifen",0.774690718274137,0.1073489661227,FALSE +"H2009","Pearson.est","FGFR inhibitor",-0.51013,-1.2,0.256,1091,0.634,"regorafenib, lucitanib, nintedanib, MK.2461",0.59176003468815,0.197910742118267,FALSE +"H2009","Pearson.est","FLT3 inhibitor",-0.40894,-0.998,0.468,847,0.75,"sorafenib, midostaurin, quizartinib, lestaurtinib, KW.2449, tozasertib, ENMD.2076, pacritinib, tandutinib, ponatinib, TG.02, gilteritinib",0.329754146925876,0.1249387366083,FALSE +"H2009","Pearson.est","glucocorticoid receptor agonist",0.24954,0.697,0.834,82,0.931,"hydrocortisone, triamcinolone.acetonide, ciclesonide",0.0788339493622613,0.0310503190186574,FALSE +"H2009","Pearson.est","glutamate receptor antagonist",-0.18465,-0.447,0.99,863,0.992,"IEM1754, kynurenic.acid, LY456236, ACDPP, diazooxonorleucine, JNJ.16259685",0.00436480540245009,0.00348832784582135,FALSE +"H2009","Pearson.est","glycogen synthase kinase inhibitor",0.2606,0.717,0.808,1073,0.958,"TWS.119, tideglusib, CHIR.98014, indirubin, AZD2858, GSK.3.inhibitor.IX, LY2090314, CHIR.99021, kenpaullone",0.0925886392254138,0.0186344909214556,FALSE +"H2009","Pearson.est","growth factor receptor inhibitor",-0.4938,-1.18,0.27,814,0.63,"AZD3463, PHA.848125, GSK1904529A, lestaurtinib, GSK1838705A",0.568636235841013,0.200659450546418,FALSE +"H2009","Pearson.est","HCV inhibitor",-0.54411,-1.31,0.168,1387,0.781,"narlaprevir, mericitabine",0.774690718274137,0.1073489661227,FALSE +"H2009","Pearson.est","HDAC inhibitor",-0.34412,-0.834,0.661,891,0.868,"RGFP966, AR.42, trichostatin.a, panobinostat, SB.939, entinostat, dacinostat, belinostat, pyroxamide, resminostat, vorinostat, R306465, M.344, RG2833",0.17979854051436,0.0614802748235081,FALSE +"H2009","Pearson.est","histamine receptor antagonist",-0.21798,-0.522,0.976,1065,1,"ICI.162846, lafutidine, BF2.649, cimetidine, tiotidine",0.0105501823333082,0,FALSE +"H2009","Pearson.est","HMGCR inhibitor",0.59536,1.64,0.0312,370,0.324,"fluvastatin, pitavastatin, simvastatin, atorvastatin, mevastatin",1.50584540598156,0.489454989793388,FALSE +"H2009","Pearson.est","HSP inhibitor",-0.58867,-1.42,0.0901,1026,0.601,"VER.49009, ganetespib, alvespimycin, tanespimycin, KW.2478, SNX.5422, NVP.AUY922, XL888",1.04527520902094,0.22112552799726,FALSE +"H2009","Pearson.est","JAK inhibitor",-0.52139,-1.28,0.195,893,0.724,"PRT062070, LY2784544, lestaurtinib, tozasertib, WHI.P154, TG.101209, AZD1480, AZ960, CEP.33779, atiprimod, pacritinib, baricitinib, TG.02",0.709965388637482,0.140261433802853,FALSE +"H2009","Pearson.est","KIT inhibitor",-0.44808,-1.08,0.373,737,0.696,"telatinib, sunitinib, masitinib, sorafenib, midostaurin, vatalanib, imatinib, regorafenib, motesanib, OSI.930, KI.8751, tandutinib, pazopanib",0.428291168191312,0.157390760389438,FALSE +"H2009","Pearson.est","MDM inhibitor",0.8192,2.29,0,206,0.0248,"idasanutlin, RITA, serdemetan, AMG.232, CGM097",Inf,1.60554831917378,TRUE +"H2009","Pearson.est","MEK inhibitor",-0.39213,-0.942,0.548,1083,0.785,"AS.703026, selumetinib, BIX.02188, nobiletin, trametinib, arctigenin, cobimetinib",0.261219441515631,0.105130343254747,FALSE +"H2009","Pearson.est","MET inhibitor",-0.70637,-1.68,0.0109,1053,0.556,"PHA.665752, LY2801653, AMG458, INC.280, NVP.BVU972",1.96257350205938,0.254925208417942,FALSE +"H2009","Pearson.est","microtubule inhibitor",-0.44527,-1.06,0.39,1114,0.719,"vinflunine, secnidazole, cytochalasin.b, D.64131",0.408935392973501,0.143271109617117,FALSE +"H2009","Pearson.est","mTOR inhibitor",0.49957,1.42,0.124,104,0.553,"torin.1, SB.2343, ku.0063794, PF.05212384, sirolimus, PKI.179, WAY.600, PP242",0.906578314837765,0.257274868695302,FALSE +"H2009","Pearson.est","NFkB pathway inhibitor",-0.4349,-1.05,0.402,1314,0.702,"Ro.106.9920, bortezomib, betulinic.acid",0.39577394691553,0.153662887870195,FALSE +"H2009","Pearson.est","opioid receptor agonist",-0.48813,-1.14,0.308,822,0.649,"cebranopadol, ADL5859, salvinorin.a, trimebutine",0.511449283499556,0.187755303199631,FALSE +"H2009","Pearson.est","p38 MAPK inhibitor",-0.41268,-0.984,0.484,1086,0.742,"SB.239063, TAK.715",0.315154638355588,0.129596094720973,FALSE +"H2009","Pearson.est","PARP inhibitor",-0.38725,-0.907,0.601,1057,0.814,"olaparib, talazoparib, PJ.34",0.22112552799726,0.0893755951107988,FALSE +"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.3926,-0.94,0.531,777,0.772,"sunitinib, masitinib, sorafenib, crenolanib, trapidil, vatalanib, SU014813, imatinib, regorafenib, motesanib, KI.8751, nintedanib, tandutinib, pazopanib, ponatinib, CP.673451",0.274905478918531,0.112382699664264,FALSE +"H2009","Pearson.est","phosphatase inhibitor",0.3028,0.818,0.683,7,0.971,"bis.maltolato.oxovanadium.IV.",0.165579296318467,0.0127807700919951,FALSE +"H2009","Pearson.est","phosphodiesterase inhibitor",-0.27883,-0.666,0.873,729,0.995,"zardaverine, cilostamide, YM.976, GSK256066, avanafil, papaverine, EMD.53998, trequinsin",0.0589857562944303,0.00217691925427455,FALSE +"H2009","Pearson.est","PI3K inhibitor",0.29781,0.816,0.663,128,0.905,"SB.2343, PF.05212384, PKI.179, YM.201636",0.178486471595227,0.0433514207947967,FALSE +"H2009","Pearson.est","PLK inhibitor",-0.55495,-1.33,0.147,1203,0.846,"rigosertib, GW.843682X, volasertib",0.832682665251824,0.0726296369609765,FALSE +"H2009","Pearson.est","potassium channel blocker",-0.61882,-1.47,0.0693,967,0.764,"oleoylethanolamide, mepivacaine, dofetilide",1.15926676538819,0.11690664142431,FALSE +"H2009","Pearson.est","PPAR receptor agonist",0.36909,1.03,0.402,147,0.818,"pterostilbene, clofibrate",0.39577394691553,0.087246696328677,FALSE +"H2009","Pearson.est","progesterone receptor agonist",0.35305,0.999,0.414,32,0.807,"norethindrone, levonorgestrel",0.382999658879101,0.0931264652779296,FALSE +"H2009","Pearson.est","proteasome inhibitor",-0.51122,-1.23,0.206,1364,0.588,"carfilzomib, bortezomib",0.686132779630847,0.230622673923862,FALSE +"H2009","Pearson.est","protein synthesis inhibitor",0.34597,0.978,0.436,177,0.777,"clofoctol, cycloheximide, chloramphenicol.palmitate, methacycline, mercaptopurine, thiostrepton",0.360513510731414,0.109578981199086,FALSE +"H2009","Pearson.est","protein tyrosine kinase inhibitor",-0.44592,-1.08,0.369,1150,0.696,"rheochrysidin, AV.412, BMS.599626",0.43297363384094,0.157390760389438,FALSE +"H2009","Pearson.est","RAF inhibitor",-0.51813,-1.24,0.202,1060,0.646,"AZ.628, regorafenib, GDC.0879, vemurafenib, TAK.632, dabrafenib, RAF265",0.694648630553376,0.189767482004916,FALSE +"H2009","Pearson.est","RET tyrosine kinase inhibitor",-0.47386,-1.15,0.27,777,0.651,"sunitinib, sorafenib, cabozantinib, apatinib, regorafenib",0.568636235841013,0.186419011431808,FALSE +"H2009","Pearson.est","retinoid receptor agonist",-0.59974,-1.45,0.0828,1375,0.639,"tamibarotene, adarotene",1.08196966321512,0.1944991418416,FALSE +"H2009","Pearson.est","ribonucleotide reductase inhibitor",-0.4396,-1.05,0.408,1197,0.702,"pentostatin, fludarabine, clofarabine",0.38933983691012,0.153662887870195,FALSE +"H2009","Pearson.est","serotonin receptor agonist",0.61344,1.74,0.0233,1,0.341,"aripiprazole",1.63264407897398,0.467245621007502,FALSE +"H2009","Pearson.est","serotonin receptor antagonist",-0.40413,-0.98,0.488,1151,0.733,"SB.216641, paliperidone, ziprasidone, SB.228357, lurasidone, RS.16566",0.311580177997289,0.134896025358872,FALSE +"H2009","Pearson.est","sodium channel blocker",-0.33001,-0.804,0.712,894,0.898,"ajmaline, oxcarbazepine, mepivacaine, benzethonium, lappaconite, triamterene, quinidine",0.147520006363144,0.0467236633326956,FALSE +"H2009","Pearson.est","src inhibitor",-0.61802,-1.49,0.0704,1320,0.815,"bosutinib, TG.100572, PP.1",1.15242734085789,0.0888423912600234,FALSE +"H2009","Pearson.est","sterol demethylase inhibitor",0.47007,1.28,0.189,275,0.576,"terconazole, lanoconazole, ketoconazole, sulconazole",0.723538195826756,0.239577516576788,FALSE +"H2009","Pearson.est","TGF beta receptor inhibitor",-0.64512,-1.56,0.0332,1332,0.656,"LY2109761, D.4476",1.47886191629596,0.18309616062434,FALSE +"H2009","Pearson.est","thymidylate synthase inhibitor",-0.69526,-1.66,0.0212,1112,0.436,"raltitrexed, trifluridine, doxifluridine, capecitabine",1.67366413907125,0.360513510731414,FALSE +"H2009","Pearson.est","topoisomerase inhibitor",0.20006,0.567,0.951,136,1,"epirubicin, beta.lapachone, voreloxin, TAS.103",0.0218194830625861,0,FALSE +"H2009","Pearson.est","tubulin polymerization inhibitor",-0.32683,-0.784,0.742,1147,0.911,"parbendazole, fosbretabulin, vindesine, docetaxel, albendazole, paclitaxel",0.129596094720973,0.0404816230270017,FALSE +"H2009","Pearson.est","tyrosine kinase inhibitor",-0.35334,-0.84,0.675,777,0.876,"sunitinib, tyrphostin.A9, CP.724714, sorafenib, AMG.208, cabozantinib, aminopurvalanol.a, apatinib, regorafenib, rheochrysidin, AV.412, hypericin, BMS.599626, tivantinib",0.170696227168975,0.0574958938319193,FALSE +"H2009","Pearson.est","VEGFR inhibitor",-0.45098,-1.09,0.35,1091,0.714,"regorafenib, lucitanib, motesanib, OSI.930, tivozanib, KI.8751, nintedanib, ENMD.2076, pazopanib, RAF265, TG.100572, MK.2461, golvatinib, foretinib",0.455931955649724,0.146301788223826,FALSE +"H2009","Pearson.est","vitamin D receptor agonist",0.46093,1.31,0.167,167,0.627,"doxercalciferol, maxacalcitol, paricalcitol",0.777283528852417,0.202732459169284,FALSE +"HCC4006","Pearson.est","EGFR inhibitor",-0.46484,-1.13,0.311,1123,0.653,"PD.153035, PD.168393, rociletinib, BIBU.1361, pelitinib, WZ.4002, icotinib, BMS.599626, gefitinib, canertinib, tucatinib, CP.724714, osimertinib, erlotinib, OSI.420, XL.647, AEE788, WZ8040",0.507239610973163,0.185086818724926,FALSE +"HCC4006","Pearson.est","Abl kinase inhibitor",-0.46968,-1.13,0.317,805,0.653,"metatinib, KW.2449, dasatinib, flumatinib, ZM.306416, tozasertib, imatinib, bosutinib",0.498940737782249,0.185086818724926,FALSE +"HCC4006","Pearson.est","acetylcholine receptor agonist",-0.41193,-0.993,0.484,594,0.837,"tremorine, xanomeline, oxiracetam, nicotine, nefiracetam, pilocarpine",0.315154638355588,0.07727454200674,FALSE +"HCC4006","Pearson.est","acetylcholine receptor antagonist",-0.39562,-0.944,0.54,680,0.869,"iododexetimide, diphemanil, methscopolamine, dicycloverine, darifenacin",0.267606240177031,0.0609802235513335,FALSE +"HCC4006","Pearson.est","adenosine receptor antagonist",-0.56551,-1.36,0.113,1249,0.682,"PSB.1115, CGS.15943, sulmazole",0.94692155651658,0.166215625343521,FALSE +"HCC4006","Pearson.est","adrenergic receptor agonist",0.29239,0.87,0.654,1029,0.914,"norepinephrine, ritodrine, terbutaline, isoxsuprine, A61603, lidamidine, methyldopa, metaraminol, oxymetazoline, buphenine, xylazine, isoetharine, epinephrine, clenbuterol, midodrine",0.184422251675733,0.0390538042661686,FALSE +"HCC4006","Pearson.est","adrenergic receptor antagonist",-0.47946,-1.15,0.279,1039,0.669,"idazoxan, RS.17053, dronedarone, vincamine, imiloxan, dihydroergocristine, oxprenolol, pindolol",0.554395796726402,0.174573882232177,FALSE +"HCC4006","Pearson.est","AKT inhibitor",-0.65591,-1.57,0.0306,1393,0.698,"AT7867, palomid.529, AZD5363, CCT128930",1.51427857351842,0.156144577376839,FALSE +"HCC4006","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.50449,-1.21,0.226,774,0.584,"SB.505124, AP26113, brigatinib, alectinib, DMH1, CEP.37440, GW.788388, AZD3463",0.645891560852599,0.233587152887601,FALSE +"HCC4006","Pearson.est","androgen receptor antagonist",-0.52111,-1.25,0.193,1009,0.58,"RU.58841, flutamide, nilutamide, bicalutamide",0.714442690992226,0.236572006437063,FALSE +"HCC4006","Pearson.est","antioxidant",-0.5388,-1.29,0.156,896,0.663,"mesna, chlorogenic.acid, benfotiamine, trolox, taurine",0.806875401645538,0.178486471595227,FALSE +"HCC4006","Pearson.est","AP inhibitor",0.52741,1.59,0.0571,87,0.156,"birinapant, GDC.0152, idronoxil",1.24336389175415,0.806875401645538,FALSE +"HCC4006","Pearson.est","ATPase inhibitor",-0.20832,-0.502,0.975,613,0.979,"rabeprazole, evodiamine, thonzonium, digitoxin, blebbistatin...., ouabain, oligomycin.a, omeprazole, digoxin",0.0109953843014632,0.00921730819686218,FALSE +"HCC4006","Pearson.est","Aurora kinase inhibitor",-0.53814,-1.29,0.16,977,0.663,"barasertib.HQPA, CCT137690, alisertib, AMG900, MK.8745, SNS.314, TAK.901, ENMD.2076, PF.03814735, tozasertib, ZM.447439, danusertib, AT.9283, CYC116, hesperadin, CCT129202",0.795880017344075,0.178486471595227,FALSE +"HCC4006","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.6141,-1.49,0.0449,1221,0.442,"tedizolid, azalomycin.b, valnemulin, tilmicosin",1.34775365899668,0.354577730650908,FALSE +"HCC4006","Pearson.est","bacterial DNA gyrase inhibitor",0.58533,1.79,0.0147,141,0.165,"sparfloxacin, sarafloxacin, finafloxacin, lomefloxacin, trovafloxacin",1.83268266525182,0.782516055786094,TRUE +"HCC4006","Pearson.est","BCL inhibitor",0.33798,1.05,0.394,178,0.798,"navitoclax, ABT.737, HA14.1",0.404503778174426,0.0979971086492706,FALSE +"HCC4006","Pearson.est","Bcr.Abl kinase inhibitor",-0.48043,-1.16,0.296,1256,0.667,"tozasertib, imatinib, bosutinib",0.528708288941061,0.175874166083451,FALSE +"HCC4006","Pearson.est","benzodiazepine receptor agonist",-0.2666,-0.628,0.907,1051,0.973,"nefiracetam, eprinomectin, lorazepam",0.0423927129399047,0.0118871597316481,FALSE +"HCC4006","Pearson.est","bromodomain inhibitor",-0.51963,-1.27,0.186,772,0.582,"I.BET151, bromosporine, OTX015, I.BET.762, JQ1....",0.730487055782084,0.235077015350112,FALSE +"HCC4006","Pearson.est","calcium channel blocker",-0.45405,-1.07,0.379,1125,0.736,"pranidipine, cinnarazine, mibefradil, tetrandrine",0.421360790031928,0.133122185662501,FALSE +"HCC4006","Pearson.est","CC chemokine receptor antagonist",-0.43609,-1.05,0.415,874,0.764,"RS.504393, SB.225002, PF.04136309, MK.0812, navarixin",0.381951903287907,0.11690664142431,FALSE +"HCC4006","Pearson.est","CDK inhibitor",-0.61361,-1.49,0.0526,1052,0.442,"arcyriaflavin.a, BMS.265246, dinaciclib, TG.02, ribociclib, abemaciclib, palbociclib, BMS.387032, AT.7519, indisulam, aminopurvalanol.a, JNJ.7706621, R547, PHA.793887",1.27901425584626,0.354577730650908,FALSE +"HCC4006","Pearson.est","CHK inhibitor",0.26162,0.789,0.655,1071,0.908,"CHIR.124, SCH.900776, LY2606368, SB.218078, AZD7762, PF.477736, LY2603618",0.183758700008217,0.0419141514789149,FALSE +"HCC4006","Pearson.est","cyclooxygenase inhibitor",-0.35683,-0.849,0.696,1104,0.858,"ketoprofen, ramifenazone, tryptanthrin, acetylsalicylsalicylic.acid, meloxicam, indoprofen, piroxicam, FR.122047",0.157390760389438,0.0665127121512946,FALSE +"HCC4006","Pearson.est","cytochrome P450 inhibitor",-0.41669,-1.01,0.478,1047,0.82,"PF.4981517, itraconazole, clotrimazole",0.320572103387881,0.0861861476162833,FALSE +"HCC4006","Pearson.est","DNA alkylating agent",-0.23597,-0.569,0.941,534,0.967,"cisplatin, carmustine, ifosfamide, mitomycin.c, estramustine, streptozotocin, melphalan, carboplatin, temozolomide, TH.302",0.0264103765727431,0.0145735259169983,FALSE +"HCC4006","Pearson.est","DNA inhibitor",-0.37558,-0.904,0.611,778,0.84,"valrubicin, tirapazamine, nimorazole, melphalan, carboplatin, chlorambucil, busulfan, bendamustine, pibenzimol, primaquine",0.213958789757446,0.0757207139381184,FALSE +"HCC4006","Pearson.est","DNA methyltransferase inhibitor",-0.47854,-1.16,0.264,1059,0.667,"SGI.1027, fdcyd, RG108",0.578396073130169,0.175874166083451,FALSE +"HCC4006","Pearson.est","DNA polymerase inhibitor",-0.47374,-1.12,0.312,1433,0.656,"idoxuridine",0.505845405981557,0.18309616062434,FALSE +"HCC4006","Pearson.est","DNA synthesis inhibitor",-0.29886,-0.714,0.831,844,0.925,"capecitabine, enocitabine, floxuridine, nelarabine, cyclocytidine, CB.10.277, anisomycin, azodicarbonamide",0.080398976215889,0.0338582672609674,FALSE +"HCC4006","Pearson.est","dopamine receptor antagonist",-0.25412,-0.614,0.914,883,0.954,"ziprasidone, nemonapride, UH.232...., paliperidone, piperacetazine, oxiperomide, mesoridazine",0.0390538042661686,0.0204516252959049,FALSE +"HCC4006","Pearson.est","estrogen receptor agonist",-0.3835,-0.921,0.591,794,0.878,"equol, estrone, estradiol.cypionate, estradiol, PPT",0.228412519118745,0.0565054840938974,FALSE +"HCC4006","Pearson.est","estrogen receptor antagonist",-0.50918,-1.23,0.209,985,0.581,"fulvestrant, tamoxifen, clomifene",0.679853713888946,0.235823867609669,FALSE +"HCC4006","Pearson.est","FGFR inhibitor",-0.61008,-1.46,0.0623,1359,0.476,"lucitanib, AZD4547, nintedanib",1.20551195334083,0.322393047279507,FALSE +"HCC4006","Pearson.est","FLT3 inhibitor",-0.37466,-0.902,0.611,1106,0.827,"tandutinib, lestaurtinib, TG.02, ENMD.2076, tozasertib, pacritinib",0.213958789757446,0.0824944904474534,FALSE +"HCC4006","Pearson.est","glucocorticoid receptor agonist",-0.33853,-0.811,0.735,897,0.887,"dexamethasone.acetate, rimexolone, fluorometholone, halobetasol.propionate, prednisolone, difluprednate, deflazacort, clobetasol.propionate, halcinonide, methylprednisolone, flumethasone",0.133712660915805,0.0520763801682736,FALSE +"HCC4006","Pearson.est","glutamate receptor antagonist",-0.29783,-0.716,0.827,740,0.938,"MTPG, diazooxonorleucine, latrepirdine, SIB.1757, tiletamine, CGP.37849, CPP, IEM1754",0.0824944904474534,0.0277971616209356,FALSE +"HCC4006","Pearson.est","glycogen synthase kinase inhibitor",0.30716,0.933,0.536,1006,0.981,"TWS.119, LY2090314, kenpaullone, GSK.3.inhibitor.IX, indirubin, tideglusib, AZD2858, CHIR.99021, CHIR.98014",0.27083521030723,0.0083309926200515,FALSE +"HCC4006","Pearson.est","growth factor receptor inhibitor",-0.71443,-1.71,0.0115,1148,0.71,"lestaurtinib, danusertib, AZD3463, GSK1838705A",1.93930215964639,0.148741651280925,FALSE +"HCC4006","Pearson.est","HCV inhibitor",-0.37988,-0.931,0.559,1160,0.876,"embelin, narlaprevir",0.252588192113577,0.0574958938319193,FALSE +"HCC4006","Pearson.est","HDAC inhibitor",-0.64704,-1.55,0.035,1149,0.608,"ACY.1215, chidamide, belinostat, mocetinostat, SB.939, PCI.24781, R306465, pyroxamide, givinostat, dacinostat, vorinostat, RG2833, resminostat, AR.42, M.344",1.45593195564972,0.216096420727265,FALSE +"HCC4006","Pearson.est","histamine receptor antagonist",-0.34994,-0.834,0.716,704,0.867,"ebastine, pheniramine, ranitidine, terfenadine, epinastine, BF2.649, ICI.162846, astemizole, nizatidine, tecastemizole, tiotidine, cimetidine, levocetirizine",0.145086977692144,0.0619809025237897,FALSE +"HCC4006","Pearson.est","HMGCR inhibitor",0.55687,1.68,0.0377,645,0.185,"pitavastatin, mevastatin, fluvastatin, atorvastatin, lovastatin, simvastatin",1.42365864979421,0.732828271596986,TRUE +"HCC4006","Pearson.est","HSP inhibitor",-0.37796,-0.917,0.593,591,0.867,"SNX.5422, NVP.AUY922, alvespimycin, KW.2478, guanidine, NMS.E973, tanespimycin, SNX.2112, PU.H71, XL888, VER.49009",0.226945306635737,0.0619809025237897,FALSE +"HCC4006","Pearson.est","JAK inhibitor",-0.53785,-1.28,0.178,1001,0.653,"TG.101209, atiprimod, filgotinib, lestaurtinib, AZD1480, TG.02, tozasertib, AT.9283, PRT062070, AZ960, pacritinib",0.749579997691106,0.185086818724926,FALSE +"HCC4006","Pearson.est","KIT inhibitor",-0.47347,-1.13,0.305,870,0.653,"telatinib, dasatinib, regorafenib, cediranib, sunitinib, motesanib, KI.8751, tandutinib, vatalanib, imatinib",0.515700160653214,0.185086818724926,FALSE +"HCC4006","Pearson.est","MDM inhibitor",-0.33969,-0.81,0.727,1417,0.873,"CGM097",0.138465589140962,0.0589857562944303,FALSE +"HCC4006","Pearson.est","MEK inhibitor",0.17572,0.537,0.971,154,0.972,"PD.318088, BIX.02188, MEK162, MEK1.2.inhibitor",0.0127807700919951,0.0123337350737254,FALSE +"HCC4006","Pearson.est","MET inhibitor",-0.5209,-1.24,0.176,1381,0.58,"AMG458",0.75448733218585,0.236572006437063,FALSE +"HCC4006","Pearson.est","microtubule inhibitor",-0.43088,-1.03,0.44,1082,0.791,"triclabendazole, D.64131, secnidazole",0.356547323513813,0.101823516502323,FALSE +"HCC4006","Pearson.est","mTOR inhibitor",-0.28087,-0.681,0.874,1212,0.944,"WYE.354, GSK2126458, palomid.529, LY303511",0.058488567365597,0.025028005701931,FALSE +"HCC4006","Pearson.est","NFkB pathway inhibitor",-0.31977,-0.772,0.789,1442,0.884,"betulinic.acid",0.10292299679058,0.0535477349869269,FALSE +"HCC4006","Pearson.est","opioid receptor agonist",-0.37101,-0.892,0.629,1207,0.814,"trimebutine, salvinorin.a",0.201349354554731,0.0893755951107988,FALSE +"HCC4006","Pearson.est","p38 MAPK inhibitor",-0.40588,-0.977,0.517,833,0.834,"skepinone.l, SB.239063, talmapimod, VX.702",0.286509456906058,0.0788339493622613,FALSE +"HCC4006","Pearson.est","PARP inhibitor",0.29796,0.849,0.664,85,0.869,"olaparib, niraparib",0.177831920631982,0.0609802235513335,FALSE +"HCC4006","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.40247,-0.986,0.488,933,0.834,"dasatinib, regorafenib, sunitinib, motesanib, KI.8751, tandutinib, CP.673451, vatalanib, crenolanib, trapidil, imatinib, nintedanib",0.311580177997289,0.0788339493622613,FALSE +"HCC4006","Pearson.est","phosphatase inhibitor",0.28841,0.888,0.585,79,0.974,"alexidine, mycophenolate.mofetil",0.23284413391782,0.0114410431213845,FALSE +"HCC4006","Pearson.est","phosphodiesterase inhibitor",0.19889,0.609,0.935,1162,0.994,"avanafil, zardaverine, anagrelide, enoximone, papaverine, cilostamide, YM.976, GSK256066, trequinsin, EMD.53998",0.0291883891274822,0.00261361560268669,FALSE +"HCC4006","Pearson.est","PI3K inhibitor",-0.3761,-0.912,0.595,1034,0.841,"buparlisib, CH5132799, TG.100713, alpelisib, GSK2126458, CUDC.907, PIK.75, taselisib, LY303511",0.22548303427145,0.0752040042020878,FALSE +"HCC4006","Pearson.est","PLK inhibitor",-0.55783,-1.34,0.116,878,0.69,"GW.843682X, GSK461364, volasertib, NMS.1286937, BI.2536",0.935542010773082,0.161150909262745,FALSE +"HCC4006","Pearson.est","potassium channel blocker",-0.44912,-1.08,0.354,1143,0.733,"oleoylethanolamide, mepivacaine",0.450996737974212,0.134896025358872,FALSE +"HCC4006","Pearson.est","PPAR receptor agonist",-0.26486,-0.626,0.926,1143,0.96,"oleoylethanolamide, S26948",0.0333890133180656,0.0177287669604316,FALSE +"HCC4006","Pearson.est","progesterone receptor agonist",0.69407,2.01,0,152,0.129,"norethindrone.acetate, norgestrel, norethindrone, dienogest, tanaproget, levonorgestrel",Inf,0.889410289700751,TRUE +"HCC4006","Pearson.est","proteasome inhibitor",-0.4007,-0.959,0.516,634,0.856,"delanzomib, oprozomib, ixazomib.citrate, carfilzomib, MG.132, bortezomib, ixazomib",0.287350298372789,0.0675262353228468,FALSE +"HCC4006","Pearson.est","protein synthesis inhibitor",-0.33867,-0.79,0.757,1155,0.873,"homoharringtonine, anguidine, thiostrepton, bruceantin, puromycin",0.120904120499927,0.0589857562944303,FALSE +"HCC4006","Pearson.est","protein tyrosine kinase inhibitor",-0.52812,-1.27,0.189,871,0.582,"AV.412, rheochrysidin, NVP.TAE226, tyrphostin.A9, BMS.599626, CP.724714",0.723538195826756,0.235077015350112,FALSE +"HCC4006","Pearson.est","RAF inhibitor",-0.33344,-0.806,0.748,1211,0.864,"CEP.32496, TAK.632, AZ.628",0.126098402135539,0.0634862575211067,FALSE +"HCC4006","Pearson.est","RET tyrosine kinase inhibitor",-0.62265,-1.49,0.0585,934,0.442,"regorafenib, sunitinib, apatinib, cabozantinib",1.23284413391782,0.354577730650908,FALSE +"HCC4006","Pearson.est","retinoid receptor agonist",0.43819,1.34,0.124,817,0.339,"adapalene, LE.135, bexarotene, adarotene, tamibarotene, AM.580, CD.437, fenretinide",0.906578314837765,0.469800301796918,FALSE +"HCC4006","Pearson.est","ribonucleotide reductase inhibitor",-0.52703,-1.27,0.177,1187,0.582,"gemcitabine, fludarabine, fludarabine.phosphate, clofarabine",0.752026733638193,0.235077015350112,FALSE +"HCC4006","Pearson.est","serotonin receptor agonist",-0.51884,-1.26,0.19,1048,0.582,"zolmitriptan, aripiprazole, ipsapirone",0.721246399047171,0.235077015350112,FALSE +"HCC4006","Pearson.est","serotonin receptor antagonist",-0.37384,-0.9,0.594,1065,0.815,"paliperidone, aripiprazole, SB.216641, SB.228357, RS.16566",0.226213555018806,0.0888423912600234,FALSE +"HCC4006","Pearson.est","sodium channel blocker",-0.57382,-1.37,0.113,1361,0.71,"butamben, triamterene, mepivacaine, quinidine",0.94692155651658,0.148741651280925,FALSE +"HCC4006","Pearson.est","src inhibitor",-0.55441,-1.31,0.145,933,0.688,"dasatinib, KX2.391, TG.100572, saracatinib, PP.1, ZM.306416, bosutinib",0.838631997765025,0.162411561764489,FALSE +"HCC4006","Pearson.est","sterol demethylase inhibitor",0.53398,1.61,0.0222,678,0.179,"sulconazole, chlormidazole, lanoconazole, ketoconazole, terconazole, posaconazole",1.65364702554936,0.747146969020107,TRUE +"HCC4006","Pearson.est","TGF beta receptor inhibitor",-0.66002,-1.57,0.0274,980,0.698,"SB.431542, LY2109761, repsox, D.4476, SB.525334",1.56224943717961,0.156144577376839,FALSE +"HCC4006","Pearson.est","thymidylate synthase inhibitor",-0.49653,-1.22,0.209,716,0.581,"trifluridine, capecitabine, doxifluridine, ftorafur, carmofur, raltitrexed",0.679853713888946,0.235823867609669,FALSE +"HCC4006","Pearson.est","topoisomerase inhibitor",0.21667,0.612,0.938,64,1,"etoposide.phosphate, epirubicin, doxorubicin, beta.lapachone",0.0277971616209356,0,FALSE +"HCC4006","Pearson.est","tubulin polymerization inhibitor",-0.38205,-0.916,0.583,849,0.851,"albendazole, docetaxel, mebendazole, combretastatin.A.4, KX2.391, parbendazole, fosbretabulin, epothilone.b, epothilone.d, oxibendazole, flubendazole, ABT.751, plinabulin",0.234331445240986,0.0700704399154121,FALSE +"HCC4006","Pearson.est","tyrosine kinase inhibitor",-0.54386,-1.31,0.144,933,0.688,"dasatinib, regorafenib, sunitinib, rheochrysidin, NVP.TAE226, AMG.208, tyrphostin.A9, BMS.599626, apatinib, CP.724714, tyrphostin.AG.99, aminopurvalanol.a, UNC2250, cabozantinib",0.84163750790475,0.162411561764489,FALSE +"HCC4006","Pearson.est","VEGFR inhibitor",-0.36958,-0.874,0.638,934,0.83,"regorafenib, cediranib, golvatinib, sunitinib, motesanib, TG.100572, KI.8751, ZM.306416, foretinib, ENMD.2076, vatalanib, lucitanib, XL.647, cabozantinib, AEE788, nintedanib",0.195179321278838,0.0809219076239261,FALSE +"HCC4006","Pearson.est","vitamin D receptor agonist",-0.64015,-1.52,0.0486,1227,0.589,"doxercalciferol, maxacalcitol, alfacalcidol, tacalcitol",1.31336373073771,0.229884705212898,FALSE +"HCC2279","Pearson.est","EGFR inhibitor",0.22676,0.551,0.957,205,0.973,"tucatinib, salvianolic.acid.B, dovitinib, BMS.599626, neratinib, AST.1306",0.0190880622231565,0.0118871597316481,FALSE +"HCC2279","Pearson.est","Abl kinase inhibitor",0.41009,0.997,0.466,691,0.701,"flumatinib, metatinib, ponatinib, imatinib, ZM.306416, bafetinib, bosutinib, nilotinib",0.33161408331,0.154281982033341,FALSE +"HCC2279","Pearson.est","acetylcholine receptor agonist",0.35607,0.877,0.605,699,0.767,"xanomeline, oxiracetam, tremorine, pilocarpine, nefiracetam",0.218244625347531,0.115204636051019,FALSE +"HCC2279","Pearson.est","acetylcholine receptor antagonist",0.53339,1.3,0.171,637,0.488,"darifenacin, methscopolamine, dicycloverine, hyoscyamine, diphemanil",0.767003889607846,0.311580177997289,FALSE +"HCC2279","Pearson.est","adenosine receptor antagonist",0.55354,1.36,0.129,100,0.437,"PSB.1115, istradefylline",0.889410289700751,0.359518563029578,FALSE +"HCC2279","Pearson.est","adrenergic receptor agonist",0.32801,0.79,0.703,348,0.805,"clenbuterol, buphenine, metaraminol, midodrine, methyldopa",0.153044674980176,0.0942041196321315,FALSE +"HCC2279","Pearson.est","adrenergic receptor antagonist",0.29171,0.717,0.807,615,0.854,"atenolol...., idazoxan, prazosin, atenolol......, practolol, dronedarone, RS.17053, levobunolol, pindolol, oxprenolol",0.0931264652779296,0.068542129310995,FALSE +"HCC2279","Pearson.est","AKT inhibitor",0.3788,0.925,0.542,258,0.754,"A.674563, uprosertib, GDC.0068",0.266000713461613,0.122628654130226,FALSE +"HCC2279","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.39437,0.962,0.515,514,0.726,"DMH1, CEP.37440, SB.505124, AZD3463, GW.788388, NVP.TAE684, crizotinib",0.288192770958809,0.139063379299906,FALSE +"HCC2279","Pearson.est","androgen receptor antagonist",-0.46351,-1.33,0.125,1178,0.622,"bicalutamide, nilutamide",0.903089986991944,0.206209615309181,FALSE +"HCC2279","Pearson.est","antioxidant",-0.38769,-1.06,0.348,1375,0.661,"chlorogenic.acid",0.458420756053419,0.17979854051436,FALSE +"HCC2279","Pearson.est","AP inhibitor",0.35689,0.876,0.589,238,0.753,"embelin, LCL.161",0.229884705212898,0.123205023799299,FALSE +"HCC2279","Pearson.est","ATPase inhibitor",0.45547,1.1,0.338,323,0.623,"digoxin, NMS.873, ouabain, omeprazole, evodiamine",0.471083299722345,0.20551195334083,FALSE +"HCC2279","Pearson.est","Aurora kinase inhibitor",0.2194,0.533,0.964,528,0.965,"danusertib, barasertib.HQPA, alisertib, ENMD.2076, MK.8745, SNS.314, CCT137690, barasertib, PHA.680632",0.0159229660971692,0.0154726866562074,FALSE +"HCC2279","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.6018,1.46,0.0764,543,0.407,"azalomycin.b, dirithromycin, tedizolid, valnemulin, josamycin, azithromycin",1.11690664142431,0.39040559077478,FALSE +"HCC2279","Pearson.est","bacterial DNA gyrase inhibitor",-0.6279,-1.74,0.0302,1151,0.435,"norfloxacin, trovafloxacin, lomefloxacin, novobiocin, finafloxacin",1.51999305704285,0.361510743045363,FALSE +"HCC2279","Pearson.est","BCL inhibitor",0.30983,0.764,0.735,108,0.824,"navitoclax",0.133712660915805,0.0840727883028842,FALSE +"HCC2279","Pearson.est","Bcr.Abl kinase inhibitor",0.47075,1.16,0.285,393,0.588,"flumatinib, metatinib, ponatinib, imatinib",0.54515513999149,0.230622673923862,FALSE +"HCC2279","Pearson.est","benzodiazepine receptor agonist",-0.34436,-0.951,0.473,1262,0.718,"CGS.20625, zaleplon, eprinomectin, bentazepam, ivermectin",0.325138859262188,0.1438755557577,FALSE +"HCC2279","Pearson.est","bromodomain inhibitor",0.62378,1.53,0.0577,417,0.334,"I.BET151, I.BET.762, JQ1...., PFI.1",1.23882418684427,0.476253533188435,FALSE +"HCC2279","Pearson.est","calcium channel blocker",0.61519,1.52,0.0637,209,0.321,"tetrandrine, efonidipine.monoethanolate, SKF.96365, penfluridol",1.19586056766465,0.493494967595128,FALSE +"HCC2279","Pearson.est","CC chemokine receptor antagonist",-0.17627,-0.488,0.991,254,0.988,"SB.225002, RS.504393, PF.04136309, UNBS.5162, MK.0812, ZK811752, navarixin",0.00392634551472468,0.00524305541237188,FALSE +"HCC2279","Pearson.est","CDK inhibitor",0.58463,1.45,0.0734,212,0.366,"ribociclib, AT.7519, abemaciclib, dinaciclib, palbociclib, JNJ.7706621, P276.00, PHA.848125, BMS.387032, PHA.793887",1.13430394008393,0.436518914605589,FALSE +"HCC2279","Pearson.est","CHK inhibitor",0.51756,1.24,0.228,8,0.54,"PF.477736",0.642065152999546,0.267606240177031,FALSE +"HCC2279","Pearson.est","cyclooxygenase inhibitor",-0.23515,-0.651,0.872,1089,0.922,"sulfasalazine, FR.122047, FK.3311, piroxicam, amfenac, metoxibutropate, AM.404, pterostilbene",0.0594835150674328,0.0352690789463706,FALSE +"HCC2279","Pearson.est","cytochrome P450 inhibitor",0.34977,0.846,0.668,73,0.784,"morin",0.175223537524454,0.105683937315562,FALSE +"HCC2279","Pearson.est","DNA alkylating agent",-0.2724,-0.768,0.719,1348,0.883,"dacarbazine, carboplatin, cyclophosphamide",0.143271109617117,0.0540392964224314,FALSE +"HCC2279","Pearson.est","DNA inhibitor",0.26159,0.635,0.911,279,0.926,"primaquine, pibenzimol, oxaliplatin, bendamustine",0.0404816230270017,0.0333890133180656,FALSE +"HCC2279","Pearson.est","DNA methyltransferase inhibitor",0.63427,1.53,0.0557,281,0.334,"SGI.1027, fdcyd, azacitidine",1.25414480482627,0.476253533188435,FALSE +"HCC2279","Pearson.est","DNA polymerase inhibitor",0.47756,1.16,0.281,305,0.588,"trifluridine, adefovir.dipivoxil, idoxuridine",0.55129368009492,0.230622673923862,FALSE +"HCC2279","Pearson.est","DNA synthesis inhibitor",-0.41384,-1.16,0.248,1314,0.577,"estramustine.phosphate, nelarabine, CB.10.277, altretamine",0.605548319173784,0.238824186844269,FALSE +"HCC2279","Pearson.est","dopamine receptor antagonist",-0.47482,-1.32,0.152,1182,0.554,"amisulpride, isofloxythepin, nemonapride, domperidone, acetophenazine, remoxipride, oxiperomide, clebopride, thioproperazine",0.818156412055227,0.25649023527157,FALSE +"HCC2279","Pearson.est","estrogen receptor agonist",-0.32708,-0.917,0.509,471,0.698,"erteberel, equol, estradiol, PPT, levonorgestrel, estrone, ethinyl.estradiol, estradiol.cypionate",0.293282217663241,0.156144577376839,FALSE +"HCC2279","Pearson.est","estrogen receptor antagonist",0.40483,1,0.455,186,0.714,"tamoxifen, clomifene",0.341988603342888,0.146301788223826,FALSE +"HCC2279","Pearson.est","FGFR inhibitor",0.77841,1.92,0.00431,124,0.149,"lucitanib, erdafitinib, dovitinib, PD.173074, regorafenib, nintedanib",2.36552272983927,0.826813731587726,TRUE +"HCC2279","Pearson.est","FLT3 inhibitor",0.51119,1.27,0.185,314,0.527,"sorafenib, dovitinib, pacritinib, ENMD.2076, tandutinib, gilteritinib, ponatinib, sunitinib",0.732828271596986,0.278189384787453,FALSE +"HCC2279","Pearson.est","glucocorticoid receptor agonist",-0.42072,-1.14,0.285,1098,0.563,"flumethasone.pivalate, clobetasol.propionate, dexamethasone.acetate, triamcinolone, piretanide, fludroxycortide, methylprednisolone, fluocinolone.acetonide, desonide, prednisolone.acetate, triamcinolone.acetonide, prednisolone, ciclesonide, hydrocortisone",0.54515513999149,0.249491605148654,FALSE +"HCC2279","Pearson.est","glutamate receptor antagonist",-0.37282,-1.04,0.376,1383,0.651,"MTPG, latrepirdine, SIB.1757",0.424812155072339,0.186419011431808,FALSE +"HCC2279","Pearson.est","glycogen synthase kinase inhibitor",-0.28214,-0.759,0.699,406,0.855,"CHIR.99021, CHIR.98014, GSK.3.inhibitor.IX, kenpaullone, tideglusib, indirubin, LY2090314, TWS.119, AZD2858",0.155522824254319,0.0680338852718274,FALSE +"HCC2279","Pearson.est","growth factor receptor inhibitor",0.5941,1.45,0.094,142,0.366,"GSK1838705A, danusertib, PHA.848125",1.0268721464003,0.436518914605589,FALSE +"HCC2279","Pearson.est","HCV inhibitor",0.39428,0.953,0.502,104,0.724,"embelin, mericitabine",0.299296282854981,0.140261433802853,FALSE +"HCC2279","Pearson.est","HDAC inhibitor",-0.25526,-0.72,0.774,1387,0.874,"mocetinostat, tacedinaline, JNJ.26481585",0.111259039317107,0.058488567365597,FALSE +"HCC2279","Pearson.est","histamine receptor antagonist",-0.35771,-0.977,0.411,1159,0.718,"epinastine, nizatidine, ranitidine, lafutidine, terfenadine, famotidine, chloropyramine",0.386158178123931,0.1438755557577,FALSE +"HCC2279","Pearson.est","HMGCR inhibitor",-0.72232,-2.03,0.0108,1326,0.187,"mevastatin, fluvastatin, pitavastatin",1.96657624451305,0.728158393463501,TRUE +"HCC2279","Pearson.est","HSP inhibitor",0.4358,1.07,0.384,554,0.606,"NMS.E973, XL888, NVP.AUY922, KW.2478, SNX.2112, alvespimycin, SNX.5422",0.415668775632469,0.217527375833714,FALSE +"HCC2279","Pearson.est","JAK inhibitor",0.46065,1.13,0.318,579,0.626,"pacritinib, AZ960, TG.101209, AZD1480, PRT062070, TG.02, filgotinib, TG.101348, lestaurtinib, baricitinib, atiprimod",0.497572880015567,0.20342566678957,FALSE +"HCC2279","Pearson.est","KIT inhibitor",0.6352,1.56,0.0388,393,0.563,"pazopanib, sorafenib, regorafenib, cediranib, masitinib, telatinib, tandutinib, sunitinib, OSI.930, lenvatinib, imatinib",1.41116827440579,0.249491605148654,FALSE +"HCC2279","Pearson.est","MDM inhibitor",-0.49762,-1.4,0.131,1101,0.596,"AMG.232, idasanutlin, serdemetan, RITA",0.882728704344236,0.224753740259764,FALSE +"HCC2279","Pearson.est","MEK inhibitor",-0.42828,-1.2,0.233,1139,0.624,"AZD8330, U.0126, TAK.733, Ro.4987655, MEK162, PD.318088, PD.184352, PD.98059, PD.198306, refametinib",0.632644078973981,0.204815410317576,FALSE +"HCC2279","Pearson.est","MET inhibitor",0.45102,1.08,0.394,388,0.622,"INC.280, AMG458, PHA.665752, LY2801653",0.404503778174426,0.206209615309181,FALSE +"HCC2279","Pearson.est","microtubule inhibitor",0.54118,1.32,0.15,241,0.494,"D.64131, vinflunine, cytochalasin.b, triclabendazole",0.823908740944319,0.306273051076353,FALSE +"HCC2279","Pearson.est","mTOR inhibitor",0.4737,1.17,0.288,340,0.634,"WYE.125132, torin.2, temsirolimus, WYE.354, AZD2014, OSI.027, deforolimus, voxtalisib, everolimus, PKI.179, LY3023414, AZD8055, XL388",0.540607512240769,0.197910742118267,FALSE +"HCC2279","Pearson.est","NFkB pathway inhibitor",0.44322,1.08,0.358,337,0.622,"Ro.106.9920, betulinic.acid, EVP4593, IKK.2.inhibitor.V, bortezomib",0.446116973356126,0.206209615309181,FALSE +"HCC2279","Pearson.est","opioid receptor agonist",-0.31128,-0.849,0.611,1408,0.783,"BW.180C",0.213958789757446,0.106238237942057,FALSE +"HCC2279","Pearson.est","p38 MAPK inhibitor",-0.41901,-1.17,0.253,1440,0.614,"CMPD.1",0.596879478824182,0.211831628858832,FALSE +"HCC2279","Pearson.est","PARP inhibitor",0.36561,0.905,0.575,769,0.771,"PJ.34, endo.IWR.1, E7449, AZD2461, talazoparib, olaparib",0.24033215531037,0.112945621949043,FALSE +"HCC2279","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.57679,1.41,0.104,393,0.388,"pazopanib, sorafenib, dovitinib, regorafenib, nintedanib, masitinib, telatinib, tandutinib, CP.673451, crenolanib, ponatinib, sunitinib, lenvatinib, imatinib",0.98296666070122,0.411168274405793,FALSE +"HCC2279","Pearson.est","phosphatase inhibitor",0.40398,0.987,0.478,335,0.701,"GSK2830371, CID.5458317, sodium.stibogluconate, AS.1949490",0.320572103387881,0.154281982033341,FALSE +"HCC2279","Pearson.est","phosphodiesterase inhibitor",0.30127,0.736,0.792,455,0.846,"trequinsin, cilostamide, papaverine, enoximone",0.101274818410506,0.0726296369609765,FALSE +"HCC2279","Pearson.est","PI3K inhibitor",0.36044,0.88,0.634,618,0.778,"BGT226, buparlisib, CH5132799, voxtalisib, PKI.179, LY3023414, taselisib, PI3K.IN.2, PI.828, LY303511, TG100.115, idelalisib, AZD6482, CUDC.907, PF.05212384, PF.04691502, PIK.75",0.197910742118267,0.109020403010311,FALSE +"HCC2279","Pearson.est","PLK inhibitor",0.70889,1.76,0.0167,239,0.335,"volasertib, NMS.1286937, GW.843682X, rigosertib",1.77728352885242,0.474955192963155,FALSE +"HCC2279","Pearson.est","potassium channel blocker",0.33607,0.833,0.679,365,0.788,"dofetilide, mepivacaine, ML133",0.168130225719498,0.103473782510445,FALSE +"HCC2279","Pearson.est","PPAR receptor agonist",-0.57111,-1.55,0.0758,1183,0.442,"S26948, pterostilbene, clofibrate",1.12033079436795,0.354577730650908,FALSE +"HCC2279","Pearson.est","progesterone receptor agonist",-0.60097,-1.65,0.0391,1249,0.406,"tanaproget, norethindrone, norgestrel, norethindrone.acetate",1.40782324260413,0.391473966422806,FALSE +"HCC2279","Pearson.est","proteasome inhibitor",0.45276,1.11,0.342,426,0.624,"MG.132, oprozomib, bortezomib, carfilzomib",0.465973893943865,0.204815410317576,FALSE +"HCC2279","Pearson.est","protein synthesis inhibitor",0.33009,0.796,0.708,282,0.812,"puromycin, tedizolid.phosphate, harringtonine, bruceantin, anguidine, homoharringtonine",0.149966742310231,0.0904439707588247,FALSE +"HCC2279","Pearson.est","protein tyrosine kinase inhibitor",0.65592,1.62,0.0314,473,0.488,"BMS.599626, AV.412, rheochrysidin, mubritinib, tyrphostin.A9, CP.724714, NVP.TAE226",1.50307035192679,0.311580177997289,FALSE +"HCC2279","Pearson.est","RAF inhibitor",0.71294,1.75,0.0151,92,0.246,"GDC.0879, sorafenib, RAF265, dabrafenib, TAK.632, regorafenib",1.82102305270683,0.609064892896621,TRUE +"HCC2279","Pearson.est","RET tyrosine kinase inhibitor",0.6351,1.54,0.0562,314,0.395,"sorafenib, regorafenib, apatinib, sunitinib",1.25026368443094,0.40340290437354,FALSE +"HCC2279","Pearson.est","retinoid receptor agonist",0.37577,0.896,0.589,221,0.769,"adarotene, fenretinide",0.229884705212898,0.114073660198569,FALSE +"HCC2279","Pearson.est","ribonucleotide reductase inhibitor",0.52812,1.3,0.175,391,0.488,"pentostatin, fludarabine.phosphate, LY2334737, cladribine",0.756961951313706,0.311580177997289,FALSE +"HCC2279","Pearson.est","serotonin receptor agonist",0.62996,1.54,0.043,398,0.395,"zolmitriptan, pardoprunox, ipsapirone, aripiprazole",1.36653154442041,0.40340290437354,FALSE +"HCC2279","Pearson.est","serotonin receptor antagonist",0.43517,1.07,0.366,653,0.606,"sertindole, lurasidone, SB.216641, aripiprazole, SB.200646, pirenperone, lerisetron, paliperidone, RS.16566, SB.228357, ziprasidone",0.436518914605589,0.217527375833714,FALSE +"HCC2279","Pearson.est","sodium channel blocker",0.4397,1.11,0.331,648,0.624,"lappaconite, mepivacaine, butamben, triamterene, quinidine, benzethonium, cibenzoline, oxcarbazepine",0.480172006224281,0.204815410317576,FALSE +"HCC2279","Pearson.est","src inhibitor",0.63045,1.54,0.0554,235,0.395,"TG.100572, PP.1, masitinib, saracatinib",1.25649023527157,0.40340290437354,FALSE +"HCC2279","Pearson.est","sterol demethylase inhibitor",-0.43252,-1.2,0.253,1209,0.624,"ketoconazole, lanoconazole, terconazole",0.596879478824182,0.204815410317576,FALSE +"HCC2279","Pearson.est","TGF beta receptor inhibitor",0.50624,1.25,0.234,718,0.544,"LY2109761, adaprev, D.4476, SB.431542, SB.525334, repsox",0.630784142589857,0.26440110030182,FALSE +"HCC2279","Pearson.est","thymidylate synthase inhibitor",0.56941,1.37,0.119,128,0.444,"trifluridine, capecitabine",0.924453038607469,0.35261702988538,FALSE +"HCC2279","Pearson.est","topoisomerase inhibitor",0.33749,0.819,0.689,341,0.794,"etoposide.phosphate, SN.38, daunorubicin, topotecan, dexrazoxane, irinotecan, fleroxacin",0.161780778092374,0.100179497572904,FALSE +"HCC2279","Pearson.est","tubulin polymerization inhibitor",0.4851,1.19,0.262,545,0.617,"vindesine, albendazole, paclitaxel, docetaxel, vincristine, parbendazole, vinorelbine, combretastatin.A.4, ABT.751, flubendazole, taltobulin, plinabulin, fosbretabulin, fenbendazole, CYT.997, verubulin, vinblastine",0.581698708680255,0.209714835966758,FALSE +"HCC2279","Pearson.est","tyrosine kinase inhibitor",0.48175,1.16,0.287,408,0.588,"tivantinib, sorafenib, regorafenib, BMS.599626, AV.412, hypericin, apatinib, aminopurvalanol.a, sunitinib, rheochrysidin, mubritinib, tyrphostin.A9, CP.724714",0.542118103266008,0.230622673923862,FALSE +"HCC2279","Pearson.est","VEGFR inhibitor",0.58025,1.44,0.0952,326,0.359,"TG.100572, foretinib, pazopanib, lucitanib, sorafenib, RAF265, golvatinib, dovitinib, PD.173074, regorafenib, nintedanib, cediranib, tivozanib, ENMD.2076, telatinib, AEE788, sunitinib, OSI.930",1.02136305161553,0.444905551421681,FALSE +"HCC2279","Pearson.est","vitamin D receptor agonist",-0.34499,-0.948,0.518,1266,0.681,"ercalcitriol, calcitriol",0.285670240254767,0.166852888087215,FALSE +"H520","Pearson.est","EGFR inhibitor",-0.43523,-1.07,0.373,831,0.729,"BIBU.1361, canertinib, PD.168393, icotinib, WZ.3146, pelitinib, XL.647, rociletinib, lapatinib, erlotinib, WZ8040, neratinib, ARRY.334543, tyrphostin.AG.1478, dacomitinib, WZ.4002, poziotinib, BIBX.1382, gefitinib, CNX.2006, tucatinib, AST.1306, AZD8931, CP.724714, CUDC.101",0.428291168191312,0.137272471682025,FALSE +"H520","Pearson.est","Abl kinase inhibitor",0.5935,1.66,0.0508,341,0.204,"GZD824, ponatinib, bafetinib, metatinib, dasatinib, tozasertib, imatinib, flumatinib",1.29413628771608,0.690369832574101,FALSE +"H520","Pearson.est","acetylcholine receptor agonist",-0.46921,-1.16,0.283,1175,0.687,"nefiracetam, oxiracetam, pilocarpine",0.54821356447571,0.16304326294045,FALSE +"H520","Pearson.est","acetylcholine receptor antagonist",-0.48604,-1.19,0.261,1057,0.691,"dicycloverine, methscopolamine, diphemanil",0.583359492661719,0.160521952625802,FALSE +"H520","Pearson.est","adenosine receptor antagonist",-0.5699,-1.41,0.0948,876,0.482,"MRS.1220, PSB.1115, CGS.15943, theophylline, SCH.58261",1.02319166266193,0.31695296176115,FALSE +"H520","Pearson.est","adrenergic receptor agonist",0.3651,1.04,0.356,255,0.628,"terbutaline, metaraminol, epinephrine, buphenine, oxymetazoline, clenbuterol",0.448550002027125,0.202040356262804,FALSE +"H520","Pearson.est","adrenergic receptor antagonist",-0.37159,-0.907,0.551,869,0.895,"dronedarone, pindolol, oxprenolol, imiloxan, atenolol...., propranolol, carvedilol, levobunolol, RS.17053, atenolol......, prazosin",0.258848401148215,0.048176964684088,FALSE +"H520","Pearson.est","AKT inhibitor",-0.35935,-0.886,0.599,950,0.857,"A.674563, GSK2110183, palomid.529, CCT128930, uprosertib, AT7867",0.222573177610689,0.0670191780768018,FALSE +"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.39813,1.08,0.333,483,0.622,"lorlatinib, brigatinib, CEP.37440, NVP.TAE684, alectinib, crizotinib, DMH1, GW.788388",0.47755576649368,0.206209615309181,FALSE +"H520","Pearson.est","androgen receptor antagonist",-0.42438,-1.04,0.395,896,0.711,"flutamide, RU.58841, bicalutamide",0.40340290437354,0.148130399270234,FALSE +"H520","Pearson.est","antioxidant",-0.56271,-1.38,0.12,1060,0.469,"chlorogenic.acid, rutin, trolox, taurine",0.920818753952375,0.328827157284917,FALSE +"H520","Pearson.est","AP inhibitor",0.31101,0.861,0.554,291,0.764,"LCL.161, birinapant, GDC.0152",0.25649023527157,0.11690664142431,FALSE +"H520","Pearson.est","ATPase inhibitor",-0.56151,-1.38,0.127,1201,0.469,"digitoxigenin, evodiamine, rabeprazole, ouabain, digoxin, k.strophanthidin",0.896196279044043,0.328827157284917,FALSE +"H520","Pearson.est","Aurora kinase inhibitor",-0.4342,-1.05,0.405,820,0.716,"alisertib, ZM.447439, CCT137690, GSK1070916, SNS.314, PF.03814735, ENMD.2076, barasertib.HQPA, barasertib, AMG900, AT.9283, MK.8745, danusertib, CCT129202, PHA.680632",0.392544976785331,0.145086977692144,FALSE +"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.40094,-0.99,0.449,906,0.756,"josamycin, radezolid, tilmicosin, azalomycin.b",0.347753658996677,0.121478204498793,FALSE +"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.44378,1.21,0.226,14,0.535,"sparfloxacin, novobiocin",0.645891560852599,0.271646217978772,FALSE +"H520","Pearson.est","BCL inhibitor",0.50644,1.45,0.105,189,0.316,"navitoclax, oridonin, gossypol, HA14.1, ABT.737",0.978810700930062,0.500312917381596,FALSE +"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.6257,1.72,0.0251,341,0.212,"GZD824, ponatinib, bafetinib, metatinib, dasatinib, tozasertib, imatinib, flumatinib",1.60032627851896,0.673664139071249,TRUE +"H520","Pearson.est","benzodiazepine receptor agonist",-0.36206,-0.89,0.608,1049,0.874,"temazepam, nefiracetam, bentazepam, eprinomectin",0.216096420727265,0.058488567365597,FALSE +"H520","Pearson.est","bromodomain inhibitor",-0.73664,-1.76,0.00992,1166,0.201,"OTX015, JQ1...., I.BET.762, I.BET151",2.00348832784582,0.696803942579511,TRUE +"H520","Pearson.est","calcium channel blocker",-0.25837,-0.629,0.893,1401,1,"mibefradil",0.0491485411114536,0,FALSE +"H520","Pearson.est","CC chemokine receptor antagonist",0.33531,0.928,0.527,343,0.699,"navarixin, UNBS.5162, RS.504393, ZK811752, MK.0812",0.278189384787453,0.155522824254319,FALSE +"H520","Pearson.est","CDK inhibitor",-0.34747,-0.851,0.628,1033,0.846,"PHA.793887, arcyriaflavin.a, TG.02, indisulam, aminopurvalanol.a, CR8..R., indirubin, BMS.387032, R547",0.202040356262804,0.0726296369609765,FALSE +"H520","Pearson.est","CHK inhibitor",0.71942,1.93,0.0161,155,0.117,"SCH.900776, LY2606368, AZD7762, LY2603618",1.79317412396815,0.931814138253838,TRUE +"H520","Pearson.est","cyclooxygenase inhibitor",-0.26074,-0.649,0.87,819,1,"piroxicam, phenazone, sulfasalazine, meloxicam, FK.3311, ketoprofen, tryptanthrin, tepoxalin, AM.404, aspirin, amfenac, naproxen",0.0604807473813815,0,FALSE +"H520","Pearson.est","cytochrome P450 inhibitor",0.38038,1.08,0.346,342,0.622,"itraconazole, eplerenone, clotrimazole, metyrapone",0.460923901207223,0.206209615309181,FALSE +"H520","Pearson.est","DNA alkylating agent",0.3364,0.936,0.495,222,0.749,"dianhydrogalactitol, estramustine, carmustine, cisplatin, cyclophosphamide",0.305394801066431,0.125518182300534,FALSE +"H520","Pearson.est","DNA inhibitor",-0.55568,-1.34,0.139,1294,0.524,"bendamustine, carboplatin, nimorazole, metronidazole, mechlorethamine",0.856985199745905,0.280668713016273,FALSE +"H520","Pearson.est","DNA methyltransferase inhibitor",0.51366,1.38,0.147,3,0.361,"decitabine",0.832682665251824,0.442492798094342,FALSE +"H520","Pearson.est","DNA polymerase inhibitor",-0.5476,-1.32,0.167,798,0.497,"menadione, famciclovir, foscarnet, cephalomannine, idoxuridine, cidofovir",0.777283528852417,0.303643611266668,FALSE +"H520","Pearson.est","DNA synthesis inhibitor",-0.41571,-1.01,0.439,1369,0.744,"artesunate, artemisinin",0.357535479757879,0.128427064454121,FALSE +"H520","Pearson.est","dopamine receptor antagonist",-0.47152,-1.15,0.303,1070,0.647,"sertindole, ziprasidone, mesoridazine, amisulpride, raclopride, thioproperazine, remoxipride",0.518557371497695,0.1890957193313,FALSE +"H520","Pearson.est","estrogen receptor agonist",-0.64061,-1.57,0.0344,1116,0.371,"PPT, estrone, erteberel, levonorgestrel",1.46344155742847,0.430626090384954,FALSE +"H520","Pearson.est","estrogen receptor antagonist",-0.43455,-1.07,0.385,1445,0.729,"clomifene",0.414539270491499,0.137272471682025,FALSE +"H520","Pearson.est","FGFR inhibitor",0.22347,0.589,0.915,256,0.937,"erdafitinib, MK.2461, dovitinib",0.0385789059335517,0.0282604091122217,FALSE +"H520","Pearson.est","FLT3 inhibitor",0.27369,0.769,0.786,256,0.86,"gilteritinib, ponatinib, sunitinib, lestaurtinib, tozasertib, dovitinib",0.104577453960592,0.0655015487564323,FALSE +"H520","Pearson.est","glucocorticoid receptor agonist",-0.62662,-1.51,0.0621,1004,0.349,"fluorometholone, triamcinolone, flumethasone, flumethasone.pivalate, rimexolone, triamcinolone.acetonide, deflazacort, fluocinolone.acetonide, ciclesonide, halcinonide, fluticasone.propionate, dexamethasone.acetate, prednisolone, betamethasone, difluprednate, methylprednisolone, desonide, hydrocortisone",1.20690839982342,0.45717457304082,FALSE +"H520","Pearson.est","glutamate receptor antagonist",-0.29769,-0.728,0.783,972,0.949,"CPP, IEM1754, CGP.37849, latrepirdine, tiletamine, ACDPP",0.106238237942057,0.0227337875727074,FALSE +"H520","Pearson.est","glycogen synthase kinase inhibitor",0.24438,0.673,0.852,128,0.884,"tideglusib, GSK.3.inhibitor.IX",0.0695604052332999,0.0535477349869269,FALSE +"H520","Pearson.est","growth factor receptor inhibitor",-0.33338,-0.82,0.659,1228,0.835,"GW.441756, danusertib",0.18111458540599,0.0783135245163979,FALSE +"H520","Pearson.est","HCV inhibitor",-0.34422,-0.848,0.65,1184,0.809,"narlaprevir, PSI.7976",0.187086643357144,0.0920514783877277,FALSE +"H520","Pearson.est","HDAC inhibitor",-0.2411,-0.601,0.94,857,0.983,"PCI.24781, scriptaid, givinostat, vorinostat, NSC.3852, panobinostat, M.344, entinostat, trichostatin.a, pyroxamide, RGFP966, mocetinostat",0.0268721464003014,0.00744648216786438,FALSE +"H520","Pearson.est","histamine receptor antagonist",-0.35082,-0.86,0.637,1071,0.878,"ebastine, zolantidine, pheniramine, nizatidine, famotidine, ranitidine",0.19586056766465,0.0565054840938974,FALSE +"H520","Pearson.est","HMGCR inhibitor",0.60774,1.71,0.0359,279,0.189,"mevastatin, atorvastatin, pitavastatin, simvastatin, lovastatin",1.44490555142168,0.723538195826756,TRUE +"H520","Pearson.est","HSP inhibitor",-0.28386,-0.687,0.828,1029,0.981,"KW.2478, tanespimycin, XL888, PU.H71",0.0819696632151199,0.0083309926200515,FALSE +"H520","Pearson.est","JAK inhibitor",-0.48517,-1.18,0.279,1136,0.678,"AT.9283, TG.101348, atiprimod, pacritinib, WHI.P154, filgotinib, TG.101209, AZD1480, CEP.33779",0.554395796726402,0.168770306132937,FALSE +"H520","Pearson.est","KIT inhibitor",0.37489,1.04,0.386,166,0.628,"KI.8751, pazopanib, sunitinib, dasatinib, motesanib",0.413412695328245,0.202040356262804,FALSE +"H520","Pearson.est","MDM inhibitor",-0.8476,-2.07,0.00141,1259,0.024,"AMG.232, RITA, nutlin.3, idasanutlin, CGM097",2.85078088734462,1.61978875828839,TRUE +"H520","Pearson.est","MEK inhibitor",0.56842,1.54,0.0884,170,0.28,"BIX.02188, cobimetinib, refametinib, TAK.733, AZD8330, arctigenin, trametinib, PD.98059, MEK162",1.05354773498693,0.552841968657781,FALSE +"H520","Pearson.est","MET inhibitor",0.8637,2.29,0,119,0.0241,"NVP.BVU972, LY2801653, INC.280, PF.04217903",Inf,1.61798295742513,TRUE +"H520","Pearson.est","microtubule inhibitor",-0.57439,-1.42,0.0835,1084,0.504,"vinblastine, triclabendazole, vinflunine, podophyllotoxin, cabazitaxel, secnidazole",1.0783135245164,0.297569463554475,FALSE +"H520","Pearson.est","mTOR inhibitor",-0.34484,-0.857,0.63,850,0.859,"LY3023414, OSI.027, ku.0063794, PI.103, PKI.179, PP242, WYE.354, palomid.529, XL388, PF.04691502, LY303511, voxtalisib, WYE.125132, torin.1, AZD8055",0.200659450546418,0.0660068361687577,FALSE +"H520","Pearson.est","NFkB pathway inhibitor",0.43122,1.17,0.277,77,0.568,"Ro.106.9920, BAY.11.7082, bortezomib, BAY.11.7085",0.557520230935551,0.245651664288981,FALSE +"H520","Pearson.est","opioid receptor agonist",-0.45092,-1.1,0.339,1135,0.723,"salvinorin.a, trimebutine",0.469800301796918,0.140861702705469,FALSE +"H520","Pearson.est","p38 MAPK inhibitor",-0.69282,-1.68,0.0163,1314,0.276,"VX.702, skepinone.l, talmapimod",1.78781239559604,0.559090917934782,FALSE +"H520","Pearson.est","PARP inhibitor",-0.48775,-1.19,0.263,1251,0.691,"E7449, endo.IWR.1, AG.14361",0.580044251510242,0.160521952625802,FALSE +"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.40791,1.13,0.294,166,0.607,"SU014813, ponatinib, KI.8751, pazopanib, sunitinib, dasatinib, motesanib",0.531652669587843,0.216811308924742,FALSE +"H520","Pearson.est","phosphatase inhibitor",0.27483,0.75,0.784,130,0.863,"BVT.948, alexidine",0.105683937315562,0.0639892042847904,FALSE +"H520","Pearson.est","phosphodiesterase inhibitor",-0.34937,-0.85,0.65,1349,0.826,"avanafil, cilostamide",0.187086643357144,0.0830199526796178,FALSE +"H520","Pearson.est","PI3K inhibitor",-0.22716,-0.548,0.964,1332,0.958,"voxtalisib, AZD6482, YM.201636",0.0159229660971692,0.0186344909214556,FALSE +"H520","Pearson.est","PLK inhibitor",-0.5447,-1.32,0.157,1188,0.497,"HMN.214, NMS.1286937",0.804100347590766,0.303643611266668,FALSE +"H520","Pearson.est","potassium channel blocker",0.2663,0.737,0.775,1064,0.827,"dofetilide, mepivacaine, meglitinide, oleoylethanolamide, ibutilide, ML133",0.11069829749369,0.0824944904474534,FALSE +"H520","Pearson.est","PPAR receptor agonist",-0.2355,-0.583,0.945,671,0.975,"GW.501516, ciprofibrate, S26948, oleoylethanolamide, fenofibrate",0.0245681914907371,0.0109953843014632,FALSE +"H520","Pearson.est","progesterone receptor agonist",-0.51982,-1.24,0.227,1256,0.643,"dienogest, levonorgestrel, norethindrone",0.643974142806877,0.191789027075778,FALSE +"H520","Pearson.est","proteasome inhibitor",0.74325,2.08,0.0139,238,0.0955,"carfilzomib, bortezomib, ixazomib, delanzomib, ONX.0914",1.8569851997459,1.01999662841625,TRUE +"H520","Pearson.est","protein synthesis inhibitor",-0.36739,-0.898,0.578,989,0.885,"florfenicol, methacycline, tedizolid.phosphate, harringtonine, azomycin..2.nitroimidazole., anguidine, cycloheximide, bruceantin",0.238072161579471,0.0530567293021746,FALSE +"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.62875,-1.53,0.0582,947,0.351,"mubritinib, PP.121, NVP.TAE226, AV.412, CP.724714",1.23507701535011,0.454692883534176,FALSE +"H520","Pearson.est","RAF inhibitor",0.52071,1.5,0.0825,201,0.297,"vemurafenib, LGX818, SB.590885, dabrafenib",1.08354605145007,0.527243550682788,FALSE +"H520","Pearson.est","RET tyrosine kinase inhibitor",0.68111,1.86,0.0301,277,0.143,"sunitinib, cabozantinib, vandetanib",1.52143350440616,0.844663962534938,TRUE +"H520","Pearson.est","retinoid receptor agonist",0.48573,1.32,0.159,192,0.409,"LE.135, CD.437, tamibarotene, fenretinide, AM.580",0.798602875679548,0.388276691992658,FALSE +"H520","Pearson.est","ribonucleotide reductase inhibitor",0.27239,0.749,0.742,108,0.836,"triapine, clofarabine",0.129596094720973,0.0777937225609836,FALSE +"H520","Pearson.est","serotonin receptor agonist",-0.74938,-1.84,0.00438,1218,0.155,"zolmitriptan, NAN.190, ipsapirone, aripiprazole",2.3585258894959,0.809668301829709,TRUE +"H520","Pearson.est","serotonin receptor antagonist",-0.47542,-1.15,0.301,1061,0.647,"SB.200646, sertindole, ziprasidone, pirenperone, aripiprazole",0.521433504406157,0.1890957193313,FALSE +"H520","Pearson.est","sodium channel blocker",-0.24758,-0.607,0.926,1157,0.999,"cibenzoline, A.803467, butamben",0.0333890133180656,0.000434511774017692,FALSE +"H520","Pearson.est","src inhibitor",0.28577,0.785,0.72,148,0.865,"TG.100572, dasatinib",0.142667503568732,0.0629838925351858,FALSE +"H520","Pearson.est","sterol demethylase inhibitor",-0.64178,-1.54,0.0546,1122,0.38,"chlormidazole, posaconazole, terconazole",1.26280735729526,0.42021640338319,FALSE +"H520","Pearson.est","TGF beta receptor inhibitor",-0.43278,-1.05,0.395,799,0.716,"LY2109761, adaprev, SB.525334, D.4476, SB.431542",0.40340290437354,0.145086977692144,FALSE +"H520","Pearson.est","thymidylate synthase inhibitor",0.36408,1,0.415,923,0.667,"doxifluridine, capecitabine, trifluridine, raltitrexed, carmofur, ftorafur",0.381951903287907,0.175874166083451,FALSE +"H520","Pearson.est","topoisomerase inhibitor",0.6655,1.94,0.0206,317,0.148,"irinotecan, topotecan, beta.lapachone, rubitecan, etoposide, daunorubicin, SN.38, doxorubicin, teniposide, epirubicin, nemorubicin, genz.644282, etoposide.phosphate, mitoxantrone, camptothecin, exatecan.mesylate",1.68613277963085,0.829738284605043,TRUE +"H520","Pearson.est","tubulin polymerization inhibitor",-0.64246,-1.57,0.0579,1084,0.371,"vinblastine, fenbendazole, CYT.997, parbendazole, podophyllotoxin, verubulin, flubendazole, indibulin, dolastatin.10, plinabulin, vincristine, epothilone.d, KX2.391, epothilone.b, taltobulin, ABT.751, albendazole, nocodazole, vinorelbine",1.23732143627256,0.430626090384954,FALSE +"H520","Pearson.est","tyrosine kinase inhibitor",-0.22714,-0.56,0.964,920,0.97,"tyrphostin.AG.99, mubritinib, PP.121, NVP.TAE226, UNC2250, aminopurvalanol.a, AV.412, CP.724714, GTP.14564",0.0159229660971692,0.0132282657337552,FALSE +"H520","Pearson.est","VEGFR inhibitor",0.34769,0.932,0.496,277,0.723,"foretinib, SU014813, KI.8751, pazopanib, sunitinib, golvatinib, TG.100572, cabozantinib, motesanib, MK.2461, tivozanib, dovitinib, vandetanib",0.304518323509803,0.140861702705469,FALSE +"H520","Pearson.est","vitamin D receptor agonist",0.31853,0.887,0.545,989,0.745,"paricalcitol, ercalcitriol, tacalcitol, maxacalcitol, calcitriol, alfacalcidol, doxercalciferol",0.263603497723358,0.127843727251707,FALSE +"HCC15","Pearson.est","EGFR inhibitor",0.35933,0.886,0.622,529,0.849,"BMS.599626, tucatinib, neratinib, osimertinib, BIBU.1361, OSI.420, AST.1306, lapatinib, AEE788, PD.153035, salvianolic.acid.B, XL.647, dovitinib, CP.724714, brigatinib, CUDC.101, BMS.690514, FERb.033, afatinib",0.206209615309181,0.0710923097560473,FALSE +"HCC15","Pearson.est","Abl kinase inhibitor",0.51676,1.26,0.202,360,0.693,"flumatinib, ZM.306416, metatinib, bafetinib, tozasertib, ponatinib",0.694648630553376,0.159266765388193,FALSE +"HCC15","Pearson.est","acetylcholine receptor agonist",0.47913,1.19,0.254,540,0.703,"tremorine, xanomeline, nicotine",0.595166283380062,0.153044674980176,FALSE +"HCC15","Pearson.est","acetylcholine receptor antagonist",0.45441,1.08,0.366,513,0.794,"darifenacin, dicycloverine, methscopolamine",0.436518914605589,0.100179497572904,FALSE +"HCC15","Pearson.est","adenosine receptor antagonist",0.64055,1.54,0.0473,231,0.43,"PSB.1115, sulmazole",1.32513885926219,0.366531544420413,FALSE +"HCC15","Pearson.est","adrenergic receptor agonist",0.3485,0.861,0.637,411,0.836,"clenbuterol, metaraminol, isoetharine, terbutaline, epinephrine, oxymetazoline, ritodrine",0.19586056766465,0.0777937225609836,FALSE +"HCC15","Pearson.est","adrenergic receptor antagonist",0.27381,0.676,0.843,787,0.991,"atipamezole, dronedarone, atenolol...., dihydroergocristine, oxprenolol, idazoxan, pindolol, practolol, levobunolol, vincamine, carvedilol, propranolol",0.0741724253752577,0.00392634551472468,FALSE +"HCC15","Pearson.est","AKT inhibitor",-0.24426,-0.688,0.82,351,0.962,"palomid.529, A.674563, CCT128930, GDC.0068, AZD5363, uprosertib, AT7867, MK.2206, triciribine, GSK2110183, ONC201",0.0861861476162833,0.0168249279621871,FALSE +"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.40312,0.978,0.491,607,0.845,"DMH1, CEP.37440, GW.788388, AZD3463, brigatinib, SB.505124, crizotinib",0.308918507877032,0.0731432910503077,FALSE +"HCC15","Pearson.est","androgen receptor antagonist",-0.2705,-0.744,0.798,1242,0.976,"nilutamide, enzalutamide",0.0979971086492706,0.0105501823333082,FALSE +"HCC15","Pearson.est","antioxidant",0.37804,0.931,0.549,184,0.828,"taurine",0.260427655549908,0.0819696632151199,FALSE +"HCC15","Pearson.est","AP inhibitor",-0.41262,-1.17,0.279,595,0.605,"tanshinone.i, embelin, LCL.161, GDC.0152, idronoxil, birinapant",0.554395796726402,0.218244625347531,FALSE +"HCC15","Pearson.est","ATPase inhibitor",-0.46673,-1.33,0.149,1383,0.518,"rabeprazole, digitoxigenin, k.strophanthidin",0.826813731587726,0.285670240254767,FALSE +"HCC15","Pearson.est","Aurora kinase inhibitor",0.2536,0.615,0.918,349,1,"ENMD.2076, alisertib, danusertib, ZM.447439, SNS.314, tozasertib",0.0371573187987575,0,FALSE +"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.50605,1.23,0.232,59,0.7,"dirithromycin, tedizolid",0.6345120151091,0.154901959985743,FALSE +"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",-0.26346,-0.766,0.739,1303,0.993,"norfloxacin, finafloxacin",0.131355561605174,0.00305075150461883,FALSE +"HCC15","Pearson.est","BCL inhibitor",0.31107,0.763,0.755,379,0.917,"navitoclax, oridonin, gossypol",0.122053048370812,0.0376306643299789,FALSE +"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",0.50047,1.23,0.209,360,0.7,"flumatinib, metatinib, bafetinib, tozasertib, ponatinib",0.679853713888946,0.154901959985743,FALSE +"HCC15","Pearson.est","benzodiazepine receptor agonist",0.22212,0.55,0.954,49,1,"ZK.93423",0.0204516252959049,0,FALSE +"HCC15","Pearson.est","bromodomain inhibitor",0.42025,1.03,0.433,842,0.806,"JQ1...., I.BET.762, PFI.1, I.BET151, bromosporine, OTX015",0.363512103646635,0.0936649581949093,FALSE +"HCC15","Pearson.est","calcium channel blocker",0.45562,1.13,0.32,617,0.704,"penfluridol, SKF.96365, fendiline, efonidipine.monoethanolate, pranidipine, mibefradil, tetrandrine",0.494850021680094,0.152427340857888,FALSE +"HCC15","Pearson.est","CC chemokine receptor antagonist",0.53718,1.33,0.161,489,0.623,"RS.504393, MK.0812, UNBS.5162, PF.04136309, SB.225002",0.79317412396815,0.20551195334083,FALSE +"HCC15","Pearson.est","CDK inhibitor",0.39908,0.96,0.523,419,0.813,"JNJ.7706621, abemaciclib, ribociclib, AT.7519, P276.00, PHA.793887, aminopurvalanol.a, palbociclib, kenpaullone, BMS.387032, R547",0.281498311132726,0.0899094544059319,FALSE +"HCC15","Pearson.est","CHK inhibitor",0.29896,0.729,0.805,72,0.944,"PF.477736",0.0942041196321315,0.025028005701931,FALSE +"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.22632,-0.644,0.898,1313,0.927,"FK.3311, pterostilbene, amfenac, AM.404",0.0467236633326956,0.0329202658555029,FALSE +"HCC15","Pearson.est","cytochrome P450 inhibitor",0.5376,1.31,0.163,199,0.594,"itraconazole, morin",0.787812395596042,0.226213555018806,FALSE +"HCC15","Pearson.est","DNA alkylating agent",0.41313,1,0.457,101,0.821,"estramustine, ifosfamide, carmustine, melphalan",0.34008379993015,0.0856568428805592,FALSE +"HCC15","Pearson.est","DNA inhibitor",0.3924,0.964,0.521,230,0.828,"primaquine, carmustine, melphalan, pibenzimol, bendamustine",0.283162276700476,0.0819696632151199,FALSE +"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.77446,1.92,0.00552,224,0.121,"SGI.1027, fdcyd, azacitidine, decitabine",2.2580609222708,0.91721462968355,TRUE +"HCC15","Pearson.est","DNA polymerase inhibitor",0.35753,0.87,0.61,217,0.839,"trifluridine, idoxuridine",0.214670164989233,0.0762380391712997,FALSE +"HCC15","Pearson.est","DNA synthesis inhibitor",-0.32688,-0.928,0.518,1386,0.838,"artesunate, altretamine",0.285670240254767,0.0767559813697235,FALSE +"HCC15","Pearson.est","dopamine receptor antagonist",-0.37326,-1.02,0.424,1280,0.704,"raclopride, oxiperomide, clebopride, remoxipride, thioproperazine",0.372634143407267,0.152427340857888,FALSE +"HCC15","Pearson.est","estrogen receptor agonist",0.35792,0.873,0.623,95,0.853,"estradiol",0.20551195334083,0.069050968832477,FALSE +"HCC15","Pearson.est","estrogen receptor antagonist",0.46419,1.15,0.282,592,0.711,"tamoxifen, fulvestrant, toremifene, clomifene, danazol",0.549750891680639,0.148130399270234,FALSE +"HCC15","Pearson.est","FGFR inhibitor",0.55863,1.35,0.131,466,0.613,"MK.2461, nintedanib, lucitanib, erdafitinib, PD.173074, regorafenib, dovitinib",0.882728704344236,0.212539525481585,FALSE +"HCC15","Pearson.est","FLT3 inhibitor",0.36646,0.899,0.592,368,0.846,"gilteritinib, tandutinib, ENMD.2076, tozasertib, ponatinib, sorafenib",0.22767829327708,0.0726296369609765,FALSE +"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.71385,-1.99,0.0122,1360,0.121,"fluticasone.propionate, fluocinolone.acetonide, prednisolone, flumethasone.pivalate, dexamethasone.acetate, triamcinolone.acetonide, ciclesonide, desonide, hydrocortisone",1.91364016932525,0.91721462968355,TRUE +"HCC15","Pearson.est","glutamate receptor antagonist",-0.28167,-0.81,0.637,1240,0.965,"CPP, tiletamine, MTPG, latrepirdine",0.19586056766465,0.0154726866562074,FALSE +"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.24145,-0.658,0.876,1424,0.954,"indirubin",0.0574958938319193,0.0204516252959049,FALSE +"HCC15","Pearson.est","growth factor receptor inhibitor",0.4641,1.13,0.311,227,0.704,"GSK1838705A, danusertib",0.507239610973163,0.152427340857888,FALSE +"HCC15","Pearson.est","HCV inhibitor",-0.43354,-1.22,0.245,1444,0.646,"PSI.7976",0.610833915635468,0.189767482004916,FALSE +"HCC15","Pearson.est","HDAC inhibitor",0.36319,0.902,0.583,409,0.861,"RG2833, dacinostat, pyroxamide, R306465, M.344, belinostat, resminostat, chidamide, trichostatin.a, givinostat, RGFP966",0.234331445240986,0.0649968485463452,FALSE +"HCC15","Pearson.est","histamine receptor antagonist",0.19439,0.479,0.985,111,1,"tiotidine, cimetidine",0.00656376950238827,0,FALSE +"HCC15","Pearson.est","HMGCR inhibitor",-0.37154,-1.09,0.317,1131,0.689,"pitavastatin, lovastatin, fluvastatin",0.498940737782249,0.161780778092374,FALSE +"HCC15","Pearson.est","HSP inhibitor",0.39029,0.952,0.529,192,0.809,"XL888, NMS.E973, SNX.5422",0.276544327964814,0.0920514783877277,FALSE +"HCC15","Pearson.est","JAK inhibitor",0.21797,0.535,0.969,751,1,"AZD1480, baricitinib, tozasertib, AZ960, atiprimod, TG.02, lestaurtinib, WHI.P154, filgotinib",0.0136762229492347,0,FALSE +"HCC15","Pearson.est","KIT inhibitor",0.48881,1.19,0.271,455,0.703,"pazopanib, motesanib, tandutinib, KI.8751, OSI.930, masitinib, sorafenib, regorafenib",0.567030709125594,0.153044674980176,FALSE +"HCC15","Pearson.est","MDM inhibitor",-0.79879,-2.18,0.00391,1199,0.0704,"serdemetan, CGM097, AMG.232, idasanutlin, RITA",2.40782324260413,1.15242734085789,TRUE +"HCC15","Pearson.est","MEK inhibitor",0.20659,0.505,0.966,346,1,"cobimetinib, trametinib, nobiletin, arctigenin",0.0150228735845067,0,FALSE +"HCC15","Pearson.est","MET inhibitor",0.72518,1.75,0.015,228,0.339,"AMG458, LY2801653, NVP.BVU972, INC.280",1.82390874094432,0.469800301796918,FALSE +"HCC15","Pearson.est","microtubule inhibitor",0.33656,0.823,0.698,261,0.862,"D.64131, vinflunine",0.156144577376839,0.0644927341752872,FALSE +"HCC15","Pearson.est","mTOR inhibitor",-0.48758,-1.35,0.161,1179,0.567,"OSI.027, AZD8055, ku.0063794, MLN0128, PKI.179, GDC.0980, PI.103, WAY.600, sirolimus, PP242, SB.2343, torin.1",0.79317412396815,0.246416941107093,FALSE +"HCC15","Pearson.est","NFkB pathway inhibitor",0.56765,1.37,0.121,93,0.609,"Ro.106.9920, bortezomib, betulinic.acid",0.91721462968355,0.215382707367125,FALSE +"HCC15","Pearson.est","opioid receptor agonist",0.41675,1.04,0.411,670,0.808,"trimebutine, salvinorin.a, cebranopadol, spiradoline",0.386158178123931,0.0925886392254138,FALSE +"HCC15","Pearson.est","p38 MAPK inhibitor",0.25137,0.606,0.906,262,1,"SB.239063",0.0428718023231869,0,FALSE +"HCC15","Pearson.est","PARP inhibitor",0.31816,0.786,0.734,40,0.901,"PJ.34",0.134303940083929,0.045275209020937,FALSE +"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.42724,1.04,0.415,466,0.808,"nintedanib, CP.673451, pazopanib, motesanib, tandutinib, KI.8751, masitinib, ponatinib, sorafenib, regorafenib, dovitinib",0.381951903287907,0.0925886392254138,FALSE +"HCC15","Pearson.est","phosphatase inhibitor",-0.29944,-0.863,0.625,1443,0.915,"bis.maltolato.oxovanadium.IV.",0.204119982655925,0.0385789059335517,FALSE +"HCC15","Pearson.est","phosphodiesterase inhibitor",0.25337,0.625,0.91,234,1,"trequinsin, YM.976",0.0409586076789064,0,FALSE +"HCC15","Pearson.est","PI3K inhibitor",-0.21711,-0.623,0.902,1142,0.908,"pilaralisib, idelalisib, GDC.0941, PI3K.IN.2, ZSTK.474, PKI.179, GDC.0980, PI.103, YM.201636, SB.2343",0.0447934624580583,0.0419141514789149,FALSE +"HCC15","Pearson.est","PLK inhibitor",0.66097,1.65,0.0254,342,0.287,"volasertib, GW.843682X, BI.2536, GSK461364, NMS.1286937",1.59516628338006,0.542118103266008,FALSE +"HCC15","Pearson.est","potassium channel blocker",0.40635,1,0.453,289,0.821,"mepivacaine, dofetilide, ML133",0.343901797987168,0.0856568428805592,FALSE +"HCC15","Pearson.est","PPAR receptor agonist",-0.36886,-1.05,0.355,1316,0.703,"pterostilbene, clofibrate",0.449771646944906,0.153044674980176,FALSE +"HCC15","Pearson.est","progesterone receptor agonist",-0.55081,-1.55,0.0567,1265,0.34,"norethindrone.acetate, levonorgestrel, tanaproget, norgestrel, norethindrone",1.24641694110709,0.468521082957745,FALSE +"HCC15","Pearson.est","proteasome inhibitor",0.6327,1.54,0.0516,430,0.43,"bortezomib, carfilzomib, MG.132, ixazomib, delanzomib, oprozomib",1.28735029837279,0.366531544420413,FALSE +"HCC15","Pearson.est","protein synthesis inhibitor",-0.25361,-0.712,0.804,1228,0.976,"azomycin..2.nitroimidazole., mercaptopurine, methacycline, cycloheximide, brefeldin.a",0.0947439512515487,0.0105501823333082,FALSE +"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.42367,1.05,0.397,635,0.839,"BMS.599626, NVP.TAE226, tyrphostin.A9, CP.724714, rheochrysidin, mubritinib",0.401209493236885,0.0762380391712997,FALSE +"HCC15","Pearson.est","RAF inhibitor",0.60764,1.46,0.0855,368,0.577,"GDC.0879, TAK.632, dabrafenib, SB.590885, RAF265, vemurafenib, LGX818, sorafenib",1.06803388527183,0.238824186844269,FALSE +"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.57105,1.37,0.11,455,0.609,"cabozantinib, apatinib, sorafenib, regorafenib",0.958607314841775,0.215382707367125,FALSE +"HCC15","Pearson.est","retinoid receptor agonist",0.57188,1.38,0.101,517,0.696,"adarotene, tamibarotene, fenretinide, AM.580, CD.437, bexarotene",0.995678626217357,0.157390760389438,FALSE +"HCC15","Pearson.est","ribonucleotide reductase inhibitor",0.48748,1.2,0.235,747,0.744,"triapine, fludarabine, clofarabine, hydroxyurea, fludarabine.phosphate, gemcitabine, LY2334737, cytarabine, cladribine, pentostatin",0.628932137728264,0.128427064454121,FALSE +"HCC15","Pearson.est","serotonin receptor agonist",-0.60023,-1.68,0.0746,1447,0.344,"aripiprazole",1.12726117252733,0.46344155742847,FALSE +"HCC15","Pearson.est","serotonin receptor antagonist",-0.43113,-1.19,0.237,1447,0.631,"aripiprazole",0.625251653989896,0.199970640755866,FALSE +"HCC15","Pearson.est","sodium channel blocker",0.33855,0.847,0.644,671,0.841,"quinidine, mepivacaine, triamterene, ajmaline, oxcarbazepine, lappaconite, butamben, benzethonium",0.191114132640188,0.0752040042020878,FALSE +"HCC15","Pearson.est","src inhibitor",0.58662,1.43,0.0819,316,0.603,"TG.100572, ZM.306416, PP.1, masitinib",1.08671609823958,0.219682687859849,FALSE +"HCC15","Pearson.est","sterol demethylase inhibitor",-0.57879,-1.56,0.0679,1300,0.414,"lanoconazole, sulconazole, ketoconazole, terconazole",1.1681302257195,0.382999658879101,FALSE +"HCC15","Pearson.est","TGF beta receptor inhibitor",0.71319,1.72,0.0131,148,0.286,"LY2109761, D.4476, repsox",1.88272870434424,0.543633966870957,FALSE +"HCC15","Pearson.est","thymidylate synthase inhibitor",0.69939,1.69,0.0135,376,0.274,"trifluridine, raltitrexed, capecitabine, ftorafur, doxifluridine",1.86966623150499,0.562249437179612,FALSE +"HCC15","Pearson.est","topoisomerase inhibitor",0.47345,1.15,0.312,293,0.711,"exatecan.mesylate, topotecan, SN.38, irinotecan, etoposide, rubitecan, genz.644282, fleroxacin, daunorubicin, etoposide.phosphate",0.505845405981557,0.148130399270234,FALSE +"HCC15","Pearson.est","tubulin polymerization inhibitor",0.17652,0.441,0.993,426,0.992,"vindesine, paclitaxel, parbendazole, docetaxel, albendazole",0.00305075150461883,0.00348832784582135,FALSE +"HCC15","Pearson.est","tyrosine kinase inhibitor",0.40247,0.966,0.511,368,0.847,"BMS.599626, hypericin, tivantinib, cabozantinib, NVP.TAE226, aminopurvalanol.a, apatinib, tyrphostin.A9, bafetinib, sorafenib",0.291579099865287,0.0721165896692931,FALSE +"HCC15","Pearson.est","VEGFR inhibitor",0.47355,1.17,0.267,252,0.722,"TG.100572, foretinib, MK.2461, nintedanib, lucitanib, golvatinib, pazopanib, motesanib, ZM.306416, cabozantinib, ENMD.2076, RAF265, KI.8751, OSI.930",0.573488738635425,0.141462802430361,FALSE +"HCC15","Pearson.est","vitamin D receptor agonist",0.52991,1.31,0.163,331,0.594,"tacalcitol, alfacalcidol",0.787812395596042,0.226213555018806,FALSE +"H460","Pearson.est","EGFR inhibitor",-0.33654,-0.804,0.745,606,0.93,"vandetanib, GW.583340, afatinib, canertinib, lapatinib, AZD8931, OSI.420, dacomitinib, PD.168393, WZ.4002, AST.1306, erlotinib, FERb.033, BIBX.1382, icotinib, gefitinib, AEE788, WZ8040, pelitinib, CUDC.101, BIBU.1361, BMS.599626, neratinib, XL.647, osimertinib, rociletinib, salvianolic.acid.B, CP.724714, tucatinib",0.127843727251707,0.0315170514460649,FALSE +"H460","Pearson.est","Abl kinase inhibitor",-0.42374,-1.03,0.429,1155,0.868,"tozasertib, flumatinib, KW.2449, bosutinib",0.367542707815276,0.0614802748235081,FALSE +"H460","Pearson.est","acetylcholine receptor agonist",-0.52174,-1.24,0.202,913,0.619,"oxiracetam, nefiracetam, xanomeline, pilocarpine",0.694648630553376,0.208309350979882,FALSE +"H460","Pearson.est","acetylcholine receptor antagonist",-0.35808,-0.863,0.65,598,0.946,"darifenacin, iododexetimide, hyoscyamine, dicycloverine, methscopolamine",0.187086643357144,0.0241088635982073,FALSE +"H460","Pearson.est","adenosine receptor antagonist",-0.4405,-1.07,0.383,796,0.833,"istradefylline, SCH.58261, PSB.1115, theophylline, sulmazole",0.416801226031377,0.0793549985932124,FALSE +"H460","Pearson.est","adrenergic receptor agonist",-0.28779,-0.699,0.878,881,0.989,"buphenine, methyldopa, clenbuterol, epinephrine, isoetharine, midodrine",0.0565054840938974,0.0048037084028206,FALSE +"H460","Pearson.est","adrenergic receptor antagonist",-0.20703,-0.495,0.972,808,0.996,"atenolol......, carvedilol, pindolol, dihydroergocristine, dronedarone, levobunolol, oxprenolol, idazoxan",0.0123337350737254,0.00174066157630127,FALSE +"H460","Pearson.est","AKT inhibitor",-0.56143,-1.38,0.0929,1170,0.522,"uprosertib, palomid.529, CCT128930, AT7867",1.03198428600636,0.282329496997738,FALSE +"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.31624,-0.763,0.802,826,0.96,"GW.788388, CEP.37440, AZD3463, DMH1, alectinib",0.0958256317158365,0.0177287669604316,FALSE +"H460","Pearson.est","androgen receptor antagonist",-0.46354,-1.12,0.311,680,0.772,"enzalutamide, RU.58841, cyproterone.acetate, bicalutamide, flutamide",0.507239610973163,0.112382699664264,FALSE +"H460","Pearson.est","antioxidant",-0.47259,-1.14,0.283,1009,0.741,"trolox, benfotiamine, taurine",0.54821356447571,0.130181792020672,FALSE +"H460","Pearson.est","AP inhibitor",0.30028,0.903,0.613,1015,0.971,"birinapant, tanshinone.i, idronoxil, GDC.0152, embelin, LCL.161",0.212539525481585,0.0127807700919951,FALSE +"H460","Pearson.est","ATPase inhibitor",-0.35642,-0.862,0.644,1035,0.93,"evodiamine, digitoxin, omeprazole, oligomycin.a, digoxin",0.191114132640188,0.0315170514460649,FALSE +"H460","Pearson.est","Aurora kinase inhibitor",-0.67101,-1.64,0.0126,1155,0.251,"tozasertib, CCT137690, CCT129202, KW.2449, ZM.447439, CYC116, alisertib, MK.8745, AMG900, barasertib.HQPA, PF.03814735, AT.9283, danusertib, ENMD.2076, SNS.314, hesperadin",1.89962945488244,0.600326278518962,FALSE +"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.52625,-1.28,0.166,879,0.666,"tilmicosin, radezolid, josamycin, dirithromycin, azalomycin.b, valnemulin",0.779891911959945,0.176525770829699,FALSE +"H460","Pearson.est","bacterial DNA gyrase inhibitor",0.59375,1.71,0.0569,593,0.367,"sparfloxacin, finafloxacin, trovafloxacin, lomefloxacin, norfloxacin, nadifloxacin, sarafloxacin, novobiocin",1.24488773360493,0.435333935747911,FALSE +"H460","Pearson.est","BCL inhibitor",-0.35416,-0.849,0.696,866,0.919,"ABT.737, venetoclax, gossypol, navitoclax, TW.37",0.157390760389438,0.0366844886138887,FALSE +"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.38812,-0.955,0.538,1155,0.862,"tozasertib, flumatinib, bosutinib",0.269217724333611,0.0644927341752872,FALSE +"H460","Pearson.est","benzodiazepine receptor agonist",-0.28999,-0.705,0.851,1025,0.999,"nefiracetam, piperazine, lorazepam",0.0700704399154121,0.000434511774017692,FALSE +"H460","Pearson.est","bromodomain inhibitor",-0.78849,-1.88,0.00113,1137,0.142,"OTX015, PFI.1, bromosporine, I.BET151, JQ1...., I.BET.762",2.94692155651658,0.847711655616944,TRUE +"H460","Pearson.est","calcium channel blocker",0.23783,0.746,0.765,1106,1,"SKF.96365, fendiline, efonidipine.monoethanolate, penfluridol, cinnarazine, pranidipine, SR.33805, tetrandrine, carboxyamidotriazole, mibefradil",0.116338564846382,0,FALSE +"H460","Pearson.est","CC chemokine receptor antagonist",-0.39548,-0.949,0.537,980,0.856,"RS.504393, PF.04136309, SB.225002, MK.0812",0.270025714300444,0.0675262353228468,FALSE +"H460","Pearson.est","CDK inhibitor",-0.56711,-1.37,0.103,1031,0.511,"TG.02, AT.7519, BMS.387032, palbociclib, indisulam, AZD5438, P276.00, PHA.793887, ribociclib, abemaciclib, BMS.265246, dinaciclib, R547, aminopurvalanol.a, JNJ.7706621",0.987162775294828,0.291579099865287,FALSE +"H460","Pearson.est","CHK inhibitor",-0.38873,-0.938,0.554,1176,0.862,"SB.218078, PF.477736",0.25649023527157,0.0644927341752872,FALSE +"H460","Pearson.est","cyclooxygenase inhibitor",-0.28997,-0.694,0.878,819,0.979,"indoprofen, suxibuzone, meloxicam, aspirin, FR.122047, acetylsalicylsalicylic.acid, ketoprofen, ramifenazone, piroxicam, phenazone",0.0565054840938974,0.00921730819686218,FALSE +"H460","Pearson.est","cytochrome P450 inhibitor",-0.23769,-0.574,0.957,610,0.995,"eplerenone, itraconazole, cobicistat, PF.4981517, clotrimazole",0.0190880622231565,0.00217691925427455,FALSE +"H460","Pearson.est","DNA alkylating agent",-0.49373,-1.19,0.242,1263,0.706,"mitomycin.c, temozolomide, TH.302, estramustine",0.616184634019569,0.151195298948196,FALSE +"H460","Pearson.est","DNA inhibitor",-0.25266,-0.614,0.931,1188,1,"pibenzimol, bendamustine, primaquine",0.0310503190186574,0,FALSE +"H460","Pearson.est","DNA methyltransferase inhibitor",-0.43546,-1.05,0.398,669,0.863,"disulfiram, RG108, decitabine, SGI.1027, fdcyd",0.400116927926312,0.0639892042847904,FALSE +"H460","Pearson.est","DNA polymerase inhibitor",-0.52124,-1.25,0.202,1384,0.684,"idoxuridine, trifluridine",0.694648630553376,0.164943898279884,FALSE +"H460","Pearson.est","DNA synthesis inhibitor",-0.22132,-0.533,0.974,670,0.998,"artemisinin, enocitabine, artesunate, azodicarbonamide, CB.10.277, floxuridine, anisomycin, cyclocytidine, capecitabine, mitomycin.c",0.0114410431213845,0.000869458712628891,FALSE +"H460","Pearson.est","dopamine receptor antagonist",-0.24653,-0.593,0.932,999,0.999,"ziprasidone, sertindole, paliperidone, lurasidone, thioproperazine, piperacetazine, UH.232....",0.0305840876460186,0.000434511774017692,FALSE +"H460","Pearson.est","estrogen receptor agonist",-0.40463,-0.962,0.547,617,0.865,"erteberel, equol, ethinyl.estradiol, estradiol.cypionate, estrone, estradiol, PPT",0.262012673666569,0.0629838925351858,FALSE +"H460","Pearson.est","estrogen receptor antagonist",-0.57048,-1.38,0.0911,1444,0.522,"clomifene",1.040481623027,0.282329496997738,FALSE +"H460","Pearson.est","FGFR inhibitor",-0.67335,-1.61,0.017,1205,0.26,"nintedanib, MK.2461, regorafenib, lucitanib",1.76955107862173,0.585026652029182,FALSE +"H460","Pearson.est","FLT3 inhibitor",-0.45728,-1.07,0.38,851,0.833,"gilteritinib, ponatinib, TG.101348, sorafenib, lestaurtinib, TG.02, tozasertib, pacritinib, KW.2449, tandutinib, ENMD.2076",0.42021640338319,0.0793549985932124,FALSE +"H460","Pearson.est","glucocorticoid receptor agonist",-0.34231,-0.818,0.733,1034,0.924,"prednisolone.hemisuccinate, fludroxycortide, deflazacort, fluorometholone, fluticasone.propionate, betamethasone, flumethasone, halobetasol.propionate, methylprednisolone, difluprednate, prednisolone",0.134896025358872,0.0343280287798933,FALSE +"H460","Pearson.est","glutamate receptor antagonist",0.19512,0.577,0.953,1168,0.953,"MTPG, kynurenic.acid, SIB.1757, felbamate, JNJ.16259685, CGP.37849, latrepirdine, LY456236, diazooxonorleucine, CPP, ACDPP, tiletamine, IEM1754",0.0209070993616736,0.0209070993616736,FALSE +"H460","Pearson.est","glycogen synthase kinase inhibitor",0.42252,1.23,0.178,840,0.492,"CHIR.98014, GSK.3.inhibitor.IX, tideglusib, TWS.119, LY2090314, kenpaullone, indirubin, CHIR.99021, AZD2858",0.749579997691106,0.30803489723264,FALSE +"H460","Pearson.est","growth factor receptor inhibitor",-0.52442,-1.25,0.182,948,0.684,"AZD3463, GW.441756, lestaurtinib, GSK1838705A, danusertib",0.739928612014925,0.164943898279884,FALSE +"H460","Pearson.est","HCV inhibitor",-0.35834,-0.863,0.666,1224,0.946,"narlaprevir, mericitabine",0.176525770829699,0.0241088635982073,FALSE +"H460","Pearson.est","HDAC inhibitor",-0.49091,-1.2,0.226,1106,0.705,"belinostat, vorinostat, mocetinostat, givinostat, R306465, AR.42, RG2833, M.344, dacinostat, trichostatin.a, resminostat",0.645891560852599,0.151810883008601,FALSE +"H460","Pearson.est","histamine receptor antagonist",-0.44073,-1.07,0.38,915,0.833,"lafutidine, levocetirizine, ebastine, astemizole, nizatidine, cimetidine, pheniramine, BF2.649, ICI.162846, tiotidine",0.42021640338319,0.0793549985932124,FALSE +"H460","Pearson.est","HMGCR inhibitor",0.53121,1.6,0.0485,682,0.302,"mevastatin, lovastatin, fluvastatin, simvastatin, pitavastatin, atorvastatin",1.31425826139774,0.519993057042849,FALSE +"H460","Pearson.est","HSP inhibitor",-0.60181,-1.47,0.0596,960,0.406,"tanespimycin, NVP.AUY922, SNX.5422, NMS.E973, alvespimycin, ganetespib, PU.H71, SNX.2112, VER.49009, XL888",1.22475374025976,0.391473966422806,FALSE +"H460","Pearson.est","JAK inhibitor",-0.64079,-1.56,0.0332,971,0.321,"TG.101348, lestaurtinib, WHI.P154, PRT062070, TG.02, baricitinib, tozasertib, pacritinib, TG.101209, atiprimod, AZD1480, AZ960, filgotinib, AT.9283",1.47886191629596,0.493494967595128,FALSE +"H460","Pearson.est","KIT inhibitor",-0.42362,-1.02,0.435,835,0.825,"motesanib, pazopanib, KI.8751, cediranib, OSI.930, sorafenib, telatinib, tandutinib, vatalanib, regorafenib",0.361510743045363,0.0835460514500749,FALSE +"H460","Pearson.est","MDM inhibitor",-0.38018,-0.917,0.598,1082,0.89,"nutlin.3, CGM097",0.223298816011589,0.0506099933550872,FALSE +"H460","Pearson.est","MEK inhibitor",0.41335,1.23,0.205,192,0.492,"U.0126, MEK162, PD.318088, AZD8330, PD.198306, BIX.02188, PD.184352, refametinib, Ro.4987655, TAK.733",0.688246138944246,0.30803489723264,FALSE +"H460","Pearson.est","MET inhibitor",-0.34219,-0.83,0.7,1322,0.92,"AMG458",0.154901959985743,0.0362121726544447,FALSE +"H460","Pearson.est","microtubule inhibitor",-0.48447,-1.17,0.247,861,0.68,"colchicine, podophyllotoxin, triclabendazole, cabazitaxel, cytochalasin.b, vinflunine, secnidazole, D.64131",0.607303046740334,0.167491087293764,FALSE +"H460","Pearson.est","mTOR inhibitor",0.39162,1.15,0.317,107,0.537,"SB.2343, sirolimus, PP242, WAY.600, OSI.027, deforolimus, torin.1, PF.05212384, temsirolimus",0.498940737782249,0.270025714300444,FALSE +"H460","Pearson.est","NFkB pathway inhibitor",-0.35827,-0.846,0.689,895,0.908,"IKK.2.inhibitor.V, Ro.106.9920, EVP4593, bortezomib, betulinic.acid",0.161780778092374,0.0419141514789149,FALSE +"H460","Pearson.est","opioid receptor agonist",-0.54533,-1.33,0.134,1298,0.553,"salvinorin.a, trimebutine",0.872895201635192,0.257274868695302,FALSE +"H460","Pearson.est","p38 MAPK inhibitor",-0.57544,-1.4,0.0842,1037,0.552,"SB.239063, SB.242235, talmapimod, VX.702",1.07468790850035,0.258060922270801,FALSE +"H460","Pearson.est","PARP inhibitor",-0.4013,-0.982,0.501,582,0.838,"endo.IWR.1, niraparib, AZD2461, E7449, PJ.34, olaparib, talazoparib",0.300162274132754,0.0767559813697235,FALSE +"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.42323,-1.02,0.454,835,0.825,"motesanib, pazopanib, ponatinib, KI.8751, axitinib, sorafenib, telatinib, trapidil, nintedanib, tandutinib, vatalanib, crenolanib, regorafenib, CP.673451",0.342944147142896,0.0835460514500749,FALSE +"H460","Pearson.est","phosphatase inhibitor",-0.40721,-0.983,0.498,1044,0.857,"mycophenolic.acid, menadione, GSK2830371, CID.5458317",0.302770657240282,0.0670191780768018,FALSE +"H460","Pearson.est","phosphodiesterase inhibitor",0.19533,0.598,0.965,116,1,"anagrelide, zardaverine, enoximone",0.0154726866562074,0,FALSE +"H460","Pearson.est","PI3K inhibitor",0.2117,0.644,0.875,135,1,"SB.2343, PI.828, PF.05212384, pilaralisib, idelalisib, PI3K.IN.2",0.0579919469776868,0,FALSE +"H460","Pearson.est","PLK inhibitor",-0.72545,-1.73,0.0078,1296,0.192,"GSK461364, GW.843682X, volasertib, NMS.1286937, BI.2536",2.10790539730952,0.71669877129645,TRUE +"H460","Pearson.est","potassium channel blocker",-0.24971,-0.605,0.943,921,1,"oleoylethanolamide, mepivacaine",0.0254883072626717,0,FALSE +"H460","Pearson.est","PPAR receptor agonist",0.47652,1.4,0.15,150,0.43,"pterostilbene, clofibrate, GW.501516",0.823908740944319,0.366531544420413,FALSE +"H460","Pearson.est","progesterone receptor agonist",0.26016,0.803,0.778,242,1,"tanaproget, norethindrone.acetate, norethindrone, levonorgestrel, norgestrel",0.109020403010311,0,FALSE +"H460","Pearson.est","proteasome inhibitor",-0.417,-1.02,0.431,725,0.825,"oprozomib, carfilzomib, ixazomib.citrate, MG.132, ixazomib, bortezomib",0.365522729839268,0.0835460514500749,FALSE +"H460","Pearson.est","protein synthesis inhibitor",-0.35774,-0.868,0.672,1316,0.976,"harringtonine, bruceantin, anguidine, puromycin",0.172630726946175,0.0105501823333082,FALSE +"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.51769,-1.24,0.192,855,0.619,"PP.121, tyrphostin.A9, NVP.TAE226, rheochrysidin, BMS.599626, CP.724714, AV.412",0.71669877129645,0.208309350979882,FALSE +"H460","Pearson.est","RAF inhibitor",-0.27524,-0.661,0.891,883,0.995,"GDC.0879, sorafenib, RAF265, regorafenib, TAK.632",0.0501222959631252,0.00217691925427455,FALSE +"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.43204,-1.04,0.416,978,0.865,"sorafenib, cabozantinib, regorafenib",0.380906669373257,0.0629838925351858,FALSE +"H460","Pearson.est","retinoid receptor agonist",-0.34887,-0.851,0.661,862,0.933,"tamibarotene, AM.580, bexarotene, adarotene",0.17979854051436,0.0301183562535,FALSE +"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.62068,-1.5,0.0414,983,0.373,"hydroxyurea, cladribine, gemcitabine, clofarabine, pentostatin, fludarabine, fludarabine.phosphate",1.3829996588791,0.428291168191312,FALSE +"H460","Pearson.est","serotonin receptor agonist",-0.75491,-1.83,0.00342,1359,0.117,"ipsapirone, zolmitriptan, aripiprazole",2.46597389394387,0.931814138253838,TRUE +"H460","Pearson.est","serotonin receptor antagonist",-0.62547,-1.53,0.0448,999,0.347,"ziprasidone, SB.200646, sertindole, paliperidone, lurasidone, SB.228357, SB.216641, RS.16566, aripiprazole",1.34872198600186,0.459670525209126,FALSE +"H460","Pearson.est","sodium channel blocker",-0.32528,-0.797,0.759,849,0.926,"triamterene, ajmaline, oxcarbazepine, mepivacaine, cibenzoline, butamben, quinidine",0.11975822410452,0.0333890133180656,FALSE +"H460","Pearson.est","src inhibitor",-0.4897,-1.17,0.258,1229,0.68,"PP.1, bosutinib, KX2.391",0.58838029403677,0.167491087293764,FALSE +"H460","Pearson.est","sterol demethylase inhibitor",-0.30299,-0.732,0.84,580,0.984,"lanoconazole, terconazole, ketoconazole, chlormidazole, posaconazole",0.0757207139381184,0.00700490156865849,FALSE +"H460","Pearson.est","TGF beta receptor inhibitor",-0.41284,-0.99,0.465,899,0.858,"SB.525334, LY2109761, D.4476",0.332547047110046,0.0665127121512946,FALSE +"H460","Pearson.est","thymidylate synthase inhibitor",-0.50849,-1.24,0.192,774,0.619,"doxifluridine, ftorafur, raltitrexed, capecitabine, trifluridine",0.71669877129645,0.208309350979882,FALSE +"H460","Pearson.est","topoisomerase inhibitor",-0.1813,-0.43,0.996,620,0.994,"fleroxacin, idarubicin, mitoxantrone, teniposide, etoposide.phosphate, amsacrine, dexrazoxane, camptothecin, daunorubicin, valrubicin, genz.644282, SN.38, amonafide, exatecan.mesylate, licochalcone.a",0.00174066157630127,0.00261361560268669,FALSE +"H460","Pearson.est","tubulin polymerization inhibitor",-0.55238,-1.34,0.115,968,0.56,"epothilone.d, vincristine, verubulin, vindesine, dolastatin.10, vinorelbine, plinabulin, taltobulin, oxibendazole, docetaxel, fosbretabulin, combretastatin.A.4, paclitaxel, epothilone.b, nocodazole, albendazole, parbendazole, KX2.391, ABT.751, flubendazole",0.939302159646388,0.2518119729938,FALSE +"H460","Pearson.est","tyrosine kinase inhibitor",-0.48551,-1.18,0.252,855,0.706,"PP.121, tyrphostin.A9, NVP.TAE226, hypericin, rheochrysidin, sorafenib, BMS.599626, cabozantinib, AMG.208, tyrphostin.AG.99, UNC2250, CP.724714, regorafenib, AV.412, tivantinib, aminopurvalanol.a",0.598599459218456,0.151195298948196,FALSE +"H460","Pearson.est","VEGFR inhibitor",-0.41568,-1.01,0.447,818,0.83,"AEE788, motesanib, pazopanib, KI.8751, cediranib, axitinib, OSI.930, sorafenib, TG.100572, cabozantinib, telatinib, RAF265, XL.647, tivozanib, nintedanib, foretinib, vatalanib, MK.2461, regorafenib, golvatinib, lucitanib, ENMD.2076",0.349692476868064,0.0809219076239261,FALSE +"H460","Pearson.est","vitamin D receptor agonist",-0.71279,-1.71,0.00896,1136,0.169,"alfacalcidol, doxercalciferol, tacalcitol",2.04769199033787,0.772113295386326,TRUE +"A549","Pearson.est","EGFR inhibitor",0.30611,0.805,0.665,242,0.825,"dacomitinib, GW.583340, pelitinib, poziotinib, ARRY.334543, tucatinib, AST.1306, WZ.3146, AZD8931, FERb.033",0.177178354696895,0.0835460514500749,FALSE +"A549","Pearson.est","Abl kinase inhibitor",0.45329,1.21,0.247,333,0.851,"ZM.306416, ponatinib, nilotinib, dasatinib, flumatinib, imatinib",0.607303046740334,0.0700704399154121,FALSE +"A549","Pearson.est","acetylcholine receptor agonist",-0.66967,-1.69,0.0255,997,0.387,"tremorine, xanomeline, nefiracetam, nicotine",1.59345981956604,0.412289034981089,FALSE +"A549","Pearson.est","acetylcholine receptor antagonist",-0.40461,-1.02,0.416,1180,0.815,"dicycloverine, darifenacin",0.380906669373257,0.0888423912600234,FALSE +"A549","Pearson.est","adenosine receptor antagonist",0.4381,1.14,0.286,7,0.766,"theophylline",0.543633966870957,0.115771230367396,FALSE +"A549","Pearson.est","adrenergic receptor agonist",-0.36432,-0.921,0.531,1215,0.796,"clenbuterol, oxymetazoline, isoxsuprine, metaraminol",0.274905478918531,0.0990869322623309,FALSE +"A549","Pearson.est","adrenergic receptor antagonist",-0.24087,-0.607,0.906,1309,0.937,"levobunolol, practolol, dronedarone",0.0428718023231869,0.0282604091122217,FALSE +"A549","Pearson.est","AKT inhibitor",0.37003,0.951,0.487,267,0.869,"CCT128930, AT7867, GSK2110183, A.674563",0.312471038785366,0.0609802235513335,FALSE +"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41726,-1.02,0.437,1017,0.815,"lorlatinib, SB.505124, crizotinib, GW.788388, DMH1, CEP.37440",0.359518563029578,0.0888423912600234,FALSE +"A549","Pearson.est","androgen receptor antagonist",-0.46564,-1.15,0.303,1434,0.686,"enzalutamide",0.518557371497695,0.163675884293248,FALSE +"A549","Pearson.est","antioxidant",0.40835,1.06,0.335,254,0.799,"taurine, trolox",0.474955192963155,0.0974532206860086,FALSE +"A549","Pearson.est","AP inhibitor",0.51824,1.34,0.163,199,0.766,"LCL.161, embelin",0.787812395596042,0.115771230367396,FALSE +"A549","Pearson.est","ATPase inhibitor",-0.64954,-1.64,0.0438,1351,0.395,"oligomycin.a, rabeprazole, omeprazole, thonzonium",1.3585258894959,0.40340290437354,FALSE +"A549","Pearson.est","Aurora kinase inhibitor",-0.56388,-1.37,0.129,1003,0.607,"MK.8745, GSK1070916, MLN.8054, MK.5108, ZM.447439, SNS.314, KW.2449, AT.9283, danusertib, CCT137690, alisertib, AMG900, barasertib, hesperadin, TAK.901, tozasertib",0.889410289700751,0.216811308924742,FALSE +"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.44815,1.16,0.26,223,0.776,"josamycin, azithromycin, dirithromycin",0.585026652029182,0.110138278741812,FALSE +"A549","Pearson.est","bacterial DNA gyrase inhibitor",0.19626,0.507,0.973,522,1,"lomefloxacin, sparfloxacin, norfloxacin, novobiocin, trovafloxacin",0.0118871597316481,0,FALSE +"A549","Pearson.est","BCL inhibitor",-0.45453,-1.12,0.327,1401,0.68,"gossypol, HA14.1",0.485452247339714,0.167491087293764,FALSE +"A549","Pearson.est","Bcr.Abl kinase inhibitor",0.45059,1.2,0.248,333,0.802,"ponatinib, nilotinib, dasatinib, flumatinib, imatinib",0.605548319173784,0.0958256317158365,FALSE +"A549","Pearson.est","benzodiazepine receptor agonist",-0.50266,-1.23,0.225,1121,0.592,"ivermectin, CL.218872, piperazine, indiplon, ZK.93423, nefiracetam",0.647817481888638,0.22767829327708,FALSE +"A549","Pearson.est","bromodomain inhibitor",0.33495,0.866,0.584,965,0.829,"PFI.1, I.BET.762, I.BET151, JQ1...., bromosporine, OTX015",0.233587152887601,0.0814454694497265,FALSE +"A549","Pearson.est","calcium channel blocker",-0.55059,-1.38,0.14,1316,0.647,"penfluridol, tetrandrine, efonidipine.monoethanolate, SKF.96365",0.853871964321762,0.1890957193313,FALSE +"A549","Pearson.est","CC chemokine receptor antagonist",0.3741,0.979,0.469,404,0.85,"MK.0812, UNBS.5162, RS.504393, SB.225002",0.328827157284917,0.0705810742857073,FALSE +"A549","Pearson.est","CDK inhibitor",-0.37535,-0.93,0.535,954,0.835,"aminopurvalanol.a, abemaciclib, BMS.387032, BMS.265246, R547, palbociclib, PHA.848125, TG.02, indisulam, PHA.793887, JNJ.7706621, AZD5438",0.271646217978772,0.0783135245163979,FALSE +"A549","Pearson.est","CHK inhibitor",-0.48819,-1.24,0.23,1076,0.611,"LY2606368, LY2603618, AZD7762, SCH.900776, CHIR.124",0.638272163982407,0.213958789757446,FALSE +"A549","Pearson.est","cyclooxygenase inhibitor",0.43137,1.11,0.358,248,0.736,"AM.404, FK.3311, pterostilbene, sulfasalazine, piroxicam, metoxibutropate",0.446116973356126,0.133122185662501,FALSE +"A549","Pearson.est","cytochrome P450 inhibitor",-0.41127,-1.01,0.438,1428,0.801,"itraconazole",0.3585258894959,0.0963674839157623,FALSE +"A549","Pearson.est","DNA alkylating agent",-0.2195,-0.545,0.949,1177,0.959,"temozolomide, cyclophosphamide, carmustine",0.0227337875727074,0.0181813928293364,FALSE +"A549","Pearson.est","DNA inhibitor",-0.25959,-0.632,0.886,860,0.959,"nithiamide, sangivamycin, valrubicin, primaquine, tirapazamine, busulfan, metronidazole, nimorazole, pibenzimol, carmustine",0.0525662781129492,0.0181813928293364,FALSE +"A549","Pearson.est","DNA methyltransferase inhibitor",0.51433,1.35,0.177,4,1,"RG108",0.752026733638193,0,FALSE +"A549","Pearson.est","DNA polymerase inhibitor",-0.31664,-0.796,0.7,916,0.885,"cephalomannine, adefovir.dipivoxil, foscarnet, menadione, famciclovir",0.154901959985743,0.0530567293021746,FALSE +"A549","Pearson.est","DNA synthesis inhibitor",0.34498,0.884,0.569,233,0.927,"capecitabine, enocitabine, estramustine.phosphate, CB.10.277, cisplatin",0.244887733604929,0.0329202658555029,FALSE +"A549","Pearson.est","dopamine receptor antagonist",-0.38066,-0.951,0.529,1224,0.855,"thioproperazine, isofloxythepin, mesoridazine, clebopride",0.276544327964814,0.0680338852718274,FALSE +"A549","Pearson.est","estrogen receptor agonist",0.34211,0.882,0.6,311,0.859,"equol, PPT, estradiol.cypionate, estrone",0.221848749616356,0.0660068361687577,FALSE +"A549","Pearson.est","estrogen receptor antagonist",0.50153,1.3,0.183,409,0.775,"danazol, tamoxifen, toremifene, clomifene",0.737548910269571,0.11069829749369,FALSE +"A549","Pearson.est","FGFR inhibitor",0.31553,0.842,0.623,190,0.843,"orantinib, lenvatinib, regorafenib",0.20551195334083,0.0741724253752577,FALSE +"A549","Pearson.est","FLT3 inhibitor",-0.3551,-0.863,0.617,1095,0.82,"KW.2449, TG.02, tandutinib, gilteritinib, TG.101348, pacritinib, sunitinib, tozasertib",0.209714835966758,0.0861861476162833,FALSE +"A549","Pearson.est","glucocorticoid receptor agonist",-0.26856,-0.658,0.859,987,0.954,"difluprednate, prednisolone.acetate, flumethasone, prednisolone, halobetasol.propionate, prednisolone.hemisuccinate, dexamethasone.acetate, hydrocortisone",0.0660068361687577,0.0204516252959049,FALSE +"A549","Pearson.est","glutamate receptor antagonist",0.3109,0.809,0.672,292,0.846,"LY456236, CGP.37849, tiletamine, MTPG, CPP",0.172630726946175,0.0726296369609765,FALSE +"A549","Pearson.est","glycogen synthase kinase inhibitor",-0.4678,-1.14,0.318,1141,0.672,"LY2090314, CHIR.98014, GSK.3.inhibitor.IX, AZD2858",0.497572880015567,0.172630726946175,FALSE +"A549","Pearson.est","growth factor receptor inhibitor",0.43209,1.12,0.313,30,0.761,"GW.441756",0.504455662453552,0.118615343229427,FALSE +"A549","Pearson.est","HCV inhibitor",0.33282,0.866,0.603,199,0.829,"narlaprevir, embelin",0.219682687859849,0.0814454694497265,FALSE +"A549","Pearson.est","HDAC inhibitor",-0.34878,-0.871,0.588,1053,0.832,"dacinostat, scriptaid, romidepsin, vorinostat, JNJ.26481585, RG2833, PCI.24781, M.344, AR.42, pyroxamide, R306465",0.230622673923862,0.0798766737092761,FALSE +"A549","Pearson.est","histamine receptor antagonist",-0.24886,-0.61,0.917,1229,0.957,"terfenadine, famotidine, chloropyramine, levocetirizine, ranitidine",0.0376306643299789,0.0190880622231565,FALSE +"A549","Pearson.est","HMGCR inhibitor",-0.59454,-1.46,0.0936,896,0.592,"simvastatin, mevastatin, fluvastatin, pitavastatin, lovastatin",1.02872415126189,0.22767829327708,FALSE +"A549","Pearson.est","HSP inhibitor",-0.3009,-0.75,0.772,942,0.883,"BIIB021, tanespimycin, NVP.AUY922, SNX.2112, guanidine, KW.2478",0.112382699664264,0.0540392964224314,FALSE +"A549","Pearson.est","JAK inhibitor",-0.34303,-0.841,0.665,1107,0.834,"TG.02, AT.9283, AZ960, TG.101348, pacritinib, tozasertib",0.177178354696895,0.0788339493622613,FALSE +"A549","Pearson.est","KIT inhibitor",0.26784,0.722,0.818,252,0.905,"cediranib, lenvatinib, regorafenib, dasatinib, masitinib",0.087246696328677,0.0433514207947967,FALSE +"A549","Pearson.est","MDM inhibitor",0.6705,1.71,0.042,355,0.462,"idasanutlin, AMG.232, CGM097, serdemetan",1.3767507096021,0.335358024443874,FALSE +"A549","Pearson.est","MEK inhibitor",-0.37851,-0.932,0.537,1221,0.862,"MEK162, PD.184352, AZD8330, refametinib, cobimetinib",0.270025714300444,0.0644927341752872,FALSE +"A549","Pearson.est","MET inhibitor",-0.76595,-1.91,0.00176,1147,0.176,"PHA.665752, LY2801653, NVP.BVU972, PF.04217903, INC.280",2.75448733218585,0.75448733218585,TRUE +"A549","Pearson.est","microtubule inhibitor",0.39159,1.02,0.4,109,0.844,"podophyllotoxin, estramustine.phosphate",0.397940008672038,0.073657553374345,FALSE +"A549","Pearson.est","mTOR inhibitor",-0.38425,-0.964,0.483,1218,0.861,"PF.04691502, SB.2343, GSK2126458, PF.05212384, PP242, WYE.354, torin.2, OSI.027",0.316052869248488,0.0649968485463452,FALSE +"A549","Pearson.est","NFkB pathway inhibitor",-0.62379,-1.54,0.0687,1155,0.468,"IKK.2.inhibitor.V, curcumin, tyloxapol, BAY.11.7085, Ro.106.9920, betulinic.acid, bortezomib",1.16304326294045,0.329754146925876,FALSE +"A549","Pearson.est","opioid receptor agonist",-0.37377,-0.926,0.534,1176,0.814,"trimebutine, BW.180C",0.272458742971444,0.0893755951107988,FALSE +"A549","Pearson.est","p38 MAPK inhibitor",-0.31705,-0.783,0.719,1422,0.857,"TAK.715",0.143271109617117,0.0670191780768018,FALSE +"A549","Pearson.est","PARP inhibitor",0.38736,1.01,0.427,117,0.824,"E7449, AG.14361",0.369572124974976,0.0840727883028842,FALSE +"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.24307,0.638,0.88,258,0.937,"ponatinib, orantinib, lenvatinib, regorafenib, dasatinib, masitinib, axitinib",0.0555173278498314,0.0282604091122217,FALSE +"A549","Pearson.est","phosphatase inhibitor",-0.32076,-0.794,0.721,1092,0.864,"mycophenolic.acid, menadione, alexidine",0.142064735280571,0.0634862575211067,FALSE +"A549","Pearson.est","phosphodiesterase inhibitor",0.45195,1.19,0.243,44,0.762,"cilostamide, trequinsin",0.614393726401688,0.1180450286604,FALSE +"A549","Pearson.est","PI3K inhibitor",-0.48773,-1.22,0.219,1211,0.578,"GDC.0941, PF.04691502, PI.828, SB.2343, GSK2126458, PF.05212384, PIK.75, pilaralisib, CUDC.907, TG100.115, CH5132799",0.659555885159882,0.238072161579471,FALSE +"A549","Pearson.est","PLK inhibitor",0.26944,0.694,0.809,67,0.919,"GSK461364",0.0920514783877277,0.0366844886138887,FALSE +"A549","Pearson.est","potassium channel blocker",-0.53722,-1.35,0.153,1261,0.597,"ML133, meglitinide",0.815308569182401,0.224025668870631,FALSE +"A549","Pearson.est","PPAR receptor agonist",0.35168,0.904,0.53,169,0.926,"fenofibrate, pterostilbene",0.275724130399211,0.0333890133180656,FALSE +"A549","Pearson.est","progesterone receptor agonist",0.29375,0.76,0.732,288,0.872,"danazol, norethindrone, norgestrel",0.135488918941608,0.0594835150674328,FALSE +"A549","Pearson.est","proteasome inhibitor",-0.66303,-1.63,0.0504,1091,0.337,"MG.132, ixazomib.citrate, ixazomib, carfilzomib, oprozomib, bortezomib",1.29756946355447,0.472370099128661,FALSE +"A549","Pearson.est","protein synthesis inhibitor",0.17889,0.457,0.993,486,0.992,"emetine, clindamycin.phosphate, harringtonine, mercaptopurine, bruceantin, cycloheximide, anguidine",0.00305075150461883,0.00348832784582135,FALSE +"A549","Pearson.est","protein tyrosine kinase inhibitor",-0.52229,-1.31,0.205,1313,0.589,"tyrphostin.A9, mubritinib, BMS.599626",0.688246138944246,0.229884705212898,FALSE +"A549","Pearson.est","RAF inhibitor",0.34281,0.883,0.574,291,0.892,"CEP.32496, AZ.628, PLX.4720, regorafenib, TAK.632",0.241088107602027,0.0496351456238769,FALSE +"A549","Pearson.est","RET tyrosine kinase inhibitor",-0.53013,-1.31,0.178,1377,0.589,"apatinib, sunitinib",0.749579997691106,0.229884705212898,FALSE +"A549","Pearson.est","retinoid receptor agonist",0.7253,1.88,0.00959,132,0.454,"adarotene, LE.135, adapalene",2.01818139282934,0.342944147142896,FALSE +"A549","Pearson.est","ribonucleotide reductase inhibitor",0.45126,1.21,0.234,274,0.851,"fludarabine.phosphate, hydroxyurea, cytarabine",0.630784142589857,0.0700704399154121,FALSE +"A549","Pearson.est","serotonin receptor agonist",-0.74424,-1.83,0.0102,1447,0.198,"aripiprazole",1.99139982823808,0.703334809738469,TRUE +"A549","Pearson.est","serotonin receptor antagonist",-0.5041,-1.26,0.198,1279,0.609,"lerisetron, RS.16566, aripiprazole",0.703334809738469,0.215382707367125,FALSE +"A549","Pearson.est","sodium channel blocker",-0.58258,-1.42,0.11,1120,0.619,"ajmaline, lappaconite, mexiletine, butamben, benzethonium, benzocaine",0.958607314841775,0.208309350979882,FALSE +"A549","Pearson.est","src inhibitor",0.51367,1.34,0.158,252,0.766,"ZM.306416, KX2.391, dasatinib, masitinib",0.801342913045577,0.115771230367396,FALSE +"A549","Pearson.est","sterol demethylase inhibitor",0.55375,1.43,0.122,415,1,"ketoconazole, chlormidazole, terconazole",0.913640169325252,0,FALSE +"A549","Pearson.est","TGF beta receptor inhibitor",-0.50925,-1.26,0.203,925,0.609,"SB.431542, D.4476, adaprev, repsox, SB.525334",0.692503962086787,0.215382707367125,FALSE +"A549","Pearson.est","thymidylate synthase inhibitor",0.68924,1.83,0.0191,98,0.326,"capecitabine, doxifluridine",1.71896663275227,0.486782399932061,FALSE +"A549","Pearson.est","topoisomerase inhibitor",-0.28179,-0.691,0.816,905,0.938,"genz.644282, valrubicin, voreloxin, camptothecin, teniposide, topotecan, dexrazoxane, irinotecan, doxorubicin, rubitecan, SN.38",0.0883098412461389,0.0277971616209356,FALSE +"A549","Pearson.est","tubulin polymerization inhibitor",0.51935,1.34,0.152,295,0.766,"dolastatin.10, combretastatin.A.4, podophyllotoxin, vincristine, taltobulin, KX2.391, CYT.997, fenbendazole, ABT.751, plinabulin, parbendazole, verubulin, vinorelbine",0.818156412055227,0.115771230367396,FALSE +"A549","Pearson.est","tyrosine kinase inhibitor",-0.36191,-0.885,0.583,1313,0.835,"tyrphostin.A9, apatinib, mubritinib, sunitinib, BMS.599626",0.234331445240986,0.0783135245163979,FALSE +"A549","Pearson.est","VEGFR inhibitor",0.26271,0.679,0.853,190,0.914,"ZM.306416, SAR131675, semaxanib, orantinib, cediranib, lenvatinib, ENMD.2076, regorafenib",0.069050968832477,0.0390538042661686,FALSE +"A549","Pearson.est","vitamin D receptor agonist",0.31275,0.822,0.651,15,0.851,"doxercalciferol",0.186419011431808,0.0700704399154121,FALSE +"HCC44","Pearson.est","EGFR inhibitor",-0.15057,-0.362,1,1116,0.999,"CNX.2006, WZ8040, WZ.4002, tyrphostin.AG.494, tyrphostin.AG.1478, BIBX.1382, rociletinib",0,0.000434511774017692,FALSE +"HCC44","Pearson.est","Abl kinase inhibitor",-0.50753,-1.22,0.234,1356,0.608,"bosutinib, tozasertib, KW.2449",0.630784142589857,0.216096420727265,FALSE +"HCC44","Pearson.est","acetylcholine receptor agonist",-0.57698,-1.37,0.129,832,0.589,"nefiracetam, tremorine, oxiracetam, xanomeline, nicotine, pilocarpine",0.889410289700751,0.229884705212898,FALSE +"HCC44","Pearson.est","acetylcholine receptor antagonist",-0.37489,-0.899,0.601,966,0.888,"dicycloverine, methscopolamine, iododexetimide",0.22112552799726,0.051587034221399,FALSE +"HCC44","Pearson.est","adenosine receptor antagonist",0.43932,1.29,0.194,93,0.403,"PSB.1115, CGS.15943",0.712198270069774,0.39469495385889,FALSE +"HCC44","Pearson.est","adrenergic receptor agonist",-0.29195,-0.703,0.851,1158,0.944,"epinephrine, xylazine, isoetharine, norepinephrine",0.0700704399154121,0.025028005701931,FALSE +"HCC44","Pearson.est","adrenergic receptor antagonist",-0.23199,-0.56,0.956,806,1,"oxprenolol, carvedilol, idazoxan, metoprolol, pindolol, levobunolol, vincamine, imiloxan, naftidrofuryl",0.0195421077238999,0,FALSE +"HCC44","Pearson.est","AKT inhibitor",-0.36152,-0.854,0.641,737,0.932,"triciribine, AZD5363, GSK2110183, A.674563, uprosertib, palomid.529, CCT128930, ONC201, AT7867",0.193141970481183,0.0305840876460186,FALSE +"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.26653,0.773,0.738,1065,0.812,"NVP.TAE684, GW.788388, CEP.37440, SB.505124, brigatinib, crizotinib, DMH1, lorlatinib, AZD3463, AP26113, alectinib",0.131943638176958,0.0904439707588247,FALSE +"HCC44","Pearson.est","androgen receptor antagonist",-0.5123,-1.25,0.184,1024,0.587,"RU.58841, flutamide, nilutamide, bicalutamide",0.735182176990464,0.231361898752386,FALSE +"HCC44","Pearson.est","antioxidant",-0.54993,-1.33,0.145,793,0.536,"taurine, rutin, mesna, benfotiamine, trolox, chlorogenic.acid",0.838631997765025,0.27083521030723,FALSE +"HCC44","Pearson.est","AP inhibitor",0.59577,1.68,0.0561,150,0.443,"tanshinone.i, birinapant, embelin",1.25103713874384,0.35359627377693,FALSE +"HCC44","Pearson.est","ATPase inhibitor",-0.42329,-1.03,0.421,1160,0.788,"oligomycin.a, rabeprazole, digitoxigenin, digitoxin",0.375717904164332,0.103473782510445,FALSE +"HCC44","Pearson.est","Aurora kinase inhibitor",-0.77635,-1.9,0.00125,1208,0.114,"ZM.447439, PHA.680632, alisertib, danusertib, barasertib.HQPA, TAK.901, MK.8745, GSK1070916, CCT129202, barasertib, CCT137690, tozasertib, SNS.314, KW.2449, AMG900, CYC116, PF.03814735, AT.9283, hesperadin",2.90308998699194,0.943095148663527,TRUE +"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.24267,-0.582,0.931,756,1,"azalomycin.b, josamycin, radezolid, tilmicosin, valnemulin",0.0310503190186574,0,FALSE +"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.3727,-0.893,0.613,1291,0.88,"norfloxacin, finafloxacin",0.212539525481585,0.0555173278498314,FALSE +"HCC44","Pearson.est","BCL inhibitor",-0.41204,-0.99,0.479,1301,0.789,"venetoclax, TW.37",0.319664486585437,0.10292299679058,FALSE +"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.41447,-0.992,0.474,1356,0.806,"bosutinib, tozasertib",0.324221658325915,0.0936649581949093,FALSE +"HCC44","Pearson.est","benzodiazepine receptor agonist",0.2672,0.773,0.737,188,0.812,"gamma.aminobutyric.acid, CL.218872, indiplon, ZK.93423, temazepam",0.132532512140949,0.0904439707588247,FALSE +"HCC44","Pearson.est","bromodomain inhibitor",-0.63731,-1.53,0.0551,919,0.409,"PFI.1, I.BET.762, OTX015, I.BET151, JQ1...., bromosporine",1.25884840114821,0.388276691992658,FALSE +"HCC44","Pearson.est","calcium channel blocker",0.46495,1.32,0.188,44,0.413,"fendiline, SKF.96365, efonidipine.monoethanolate",0.72584215073632,0.384049948343599,FALSE +"HCC44","Pearson.est","CC chemokine receptor antagonist",0.30412,0.875,0.575,136,0.769,"ZK811752, UNBS.5162",0.24033215531037,0.114073660198569,FALSE +"HCC44","Pearson.est","CDK inhibitor",-0.43104,-1.04,0.425,945,0.79,"TG.02, abemaciclib, AZD5438, palbociclib, PHA.793887, indisulam, PHA.848125, R547, aminopurvalanol.a, BMS.265246",0.371611069949688,0.102372908709559,FALSE +"HCC44","Pearson.est","CHK inhibitor",-0.45814,-1.1,0.362,1104,0.72,"LY2606368, LY2603618, SB.218078",0.441291429466834,0.142667503568732,FALSE +"HCC44","Pearson.est","cyclooxygenase inhibitor",-0.43785,-1.06,0.427,1020,0.768,"tepoxalin, curcumin, naproxen, aspirin, meloxicam, amfenac, FR.122047, ketoprofen, piroxicam",0.369572124974976,0.114638779968488,FALSE +"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.32511,-0.759,0.78,912,0.963,"clotrimazole, PF.4981517, eplerenone, cobicistat",0.10790539730952,0.0163737128754655,FALSE +"HCC44","Pearson.est","DNA alkylating agent",-0.46814,-1.12,0.318,1396,0.699,"carboplatin, streptozotocin, cyclophosphamide",0.497572880015567,0.155522824254319,FALSE +"HCC44","Pearson.est","DNA inhibitor",0.16281,0.466,1,173,0.994,"carmustine, bendamustine, sangivamycin",0,0.00261361560268669,FALSE +"HCC44","Pearson.est","DNA methyltransferase inhibitor",0.41132,1.19,0.238,239,0.503,"azacitidine, fdcyd, SGI.1027",0.623423042943488,0.298432014944073,FALSE +"HCC44","Pearson.est","DNA polymerase inhibitor",-0.52587,-1.25,0.199,1015,0.587,"famciclovir, idoxuridine, menadione, cephalomannine",0.701146923590293,0.231361898752386,FALSE +"HCC44","Pearson.est","DNA synthesis inhibitor",-0.48238,-1.15,0.315,1217,0.652,"anisomycin, artemisinin, altretamine, CB.10.277, artesunate",0.501689446210399,0.18575240426808,FALSE +"HCC44","Pearson.est","dopamine receptor antagonist",-0.50287,-1.2,0.266,1090,0.606,"amisulpride, remoxipride, oxiperomide, piperacetazine, raclopride, UH.232...., thioproperazine",0.575118363368933,0.217527375833714,FALSE +"HCC44","Pearson.est","estrogen receptor agonist",-0.53981,-1.29,0.165,1221,0.608,"estrone, estradiol.cypionate, ethinyl.estradiol, PPT",0.782516055786094,0.216096420727265,FALSE +"HCC44","Pearson.est","estrogen receptor antagonist",-0.33336,-0.812,0.718,1303,0.922,"clomifene",0.1438755557577,0.0352690789463706,FALSE +"HCC44","Pearson.est","FGFR inhibitor",0.4865,1.4,0.104,77,0.363,"erdafitinib, dovitinib, PD.173074",0.98296666070122,0.440093374963888,FALSE +"HCC44","Pearson.est","FLT3 inhibitor",-0.38171,-0.921,0.568,1032,0.865,"tyrphostin.AG.1296, lestaurtinib, quizartinib, TG.101348, pacritinib, tozasertib, KW.2449",0.245651664288981,0.0629838925351858,FALSE +"HCC44","Pearson.est","glucocorticoid receptor agonist",-0.6542,-1.59,0.0335,973,0.378,"fludroxycortide, halobetasol.propionate, triamcinolone, prednisolone.hemisuccinate, betamethasone, fluorometholone, difluprednate, flumethasone, clobetasol.propionate, flumethasone.pivalate, rimexolone, deflazacort, halcinonide, prednisolone.acetate, beclomethasone.dipropionate, fluticasone.propionate, desonide, hydrocortisone, dexamethasone.acetate, methylprednisolone, ciclesonide, fluocinolone.acetonide, prednisolone",1.47495519296315,0.422508200162775,FALSE +"HCC44","Pearson.est","glutamate receptor antagonist",-0.35182,-0.843,0.665,1275,0.93,"SIB.1757, latrepirdine, tiletamine",0.177178354696895,0.0315170514460649,FALSE +"HCC44","Pearson.est","glycogen synthase kinase inhibitor",0.26268,0.759,0.773,1070,0.793,"CHIR.98014, GSK.3.inhibitor.IX, CHIR.99021, indirubin, kenpaullone, tideglusib, LY2090314, TWS.119, AZD2858",0.111820506081675,0.100726812682396,FALSE +"HCC44","Pearson.est","growth factor receptor inhibitor",-0.49715,-1.19,0.268,917,0.605,"AZD3463, lestaurtinib, PHA.848125, danusertib",0.571865205971211,0.218244625347531,FALSE +"HCC44","Pearson.est","HCV inhibitor",-0.53316,-1.27,0.173,1306,0.626,"PSI.7976, narlaprevir",0.761953896871205,0.20342566678957,FALSE +"HCC44","Pearson.est","HDAC inhibitor",-0.43684,-1.07,0.388,994,0.768,"PCI.24781, romidepsin, SB.939, belinostat, mocetinostat, RG2833, M.344, dacinostat, givinostat, vorinostat, trichostatin.a, AR.42, ACY.1215",0.411168274405793,0.114638779968488,FALSE +"HCC44","Pearson.est","histamine receptor antagonist",-0.55757,-1.33,0.138,1095,0.536,"lafutidine, tiotidine, BF2.649, pheniramine, nizatidine, terfenadine, ICI.162846, famotidine",0.860120913598763,0.27083521030723,FALSE +"HCC44","Pearson.est","HMGCR inhibitor",-0.60765,-1.43,0.0798,1202,0.573,"fluvastatin, pitavastatin",1.09799710864927,0.24184537803261,FALSE +"HCC44","Pearson.est","HSP inhibitor",-0.58272,-1.4,0.114,934,0.608,"SNX.5422, alvespimycin, PU.H71, XL888, NVP.AUY922, SNX.2112, ganetespib, BIIB021, VER.49009, tanespimycin",0.943095148663527,0.216096420727265,FALSE +"HCC44","Pearson.est","JAK inhibitor",-0.60705,-1.46,0.0832,1075,0.552,"lestaurtinib, filgotinib, AZ960, TG.101348, PRT062070, WHI.P154, pacritinib, TG.101209, tozasertib, AT.9283",1.07987667370928,0.258060922270801,FALSE +"HCC44","Pearson.est","KIT inhibitor",-0.16966,-0.411,0.999,679,1,"regorafenib, cediranib, midostaurin, KI.8751, tandutinib, masitinib, imatinib, telatinib, vatalanib",0.000434511774017692,0,FALSE +"HCC44","Pearson.est","MDM inhibitor",-0.76634,-1.86,0.00369,1182,0.0913,"AMG.232, nutlin.3, idasanutlin, RITA, CGM097",2.43297363384094,1.0395292224657,TRUE +"HCC44","Pearson.est","MEK inhibitor",-0.19453,-0.471,0.987,890,1,"PD.0325901, PD.98059, PD.198306, PD.184352, refametinib, nobiletin",0.00568284733036327,0,FALSE +"HCC44","Pearson.est","MET inhibitor",0.5199,1.5,0.0718,283,0.436,"INC.280, NVP.BVU972, LY2801653, AMG458",1.1438755557577,0.360513510731414,FALSE +"HCC44","Pearson.est","microtubule inhibitor",-0.52587,-1.26,0.198,916,0.621,"cytochalasin.b, podophyllotoxin, vinblastine, secnidazole, cabazitaxel, colchicine, D.64131",0.703334809738469,0.20690839982342,FALSE +"HCC44","Pearson.est","mTOR inhibitor",0.36846,1.08,0.324,312,0.635,"temsirolimus, PF.05212384, OSI.027, everolimus, deforolimus, GSK2126458, torin.2, AZD2014, XL388, voxtalisib, WAY.600, LY3023414, sirolimus, AZD8055",0.489454989793388,0.197226274708024,FALSE +"HCC44","Pearson.est","NFkB pathway inhibitor",-0.31148,-0.738,0.807,765,0.973,"EVP4593, IKK.2.inhibitor.V, parthenolide, BAY.11.7085, curcumin, betulinic.acid",0.0931264652779296,0.0118871597316481,FALSE +"HCC44","Pearson.est","opioid receptor agonist",-0.5038,-1.2,0.23,961,0.606,"ADL5859, BW.180C, trimebutine, salvinorin.a",0.638272163982407,0.217527375833714,FALSE +"HCC44","Pearson.est","p38 MAPK inhibitor",-0.5311,-1.24,0.228,1346,0.585,"CMPD.1, VX.702",0.642065152999546,0.23284413391782,FALSE +"HCC44","Pearson.est","PARP inhibitor",-0.42984,-1.01,0.456,852,0.789,"AZD2461, E7449, endo.IWR.1, talazoparib, AG.14361, niraparib",0.341035157335565,0.10292299679058,FALSE +"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30518,-0.72,0.819,1040,0.96,"CP.673451, imatinib, telatinib, trapidil, nintedanib, crenolanib, axitinib, vatalanib",0.0867160982395816,0.0177287669604316,FALSE +"HCC44","Pearson.est","phosphatase inhibitor",-0.48369,-1.15,0.303,1270,0.652,"menadione, CID.5458317, bis.maltolato.oxovanadium.IV.",0.518557371497695,0.18575240426808,FALSE +"HCC44","Pearson.est","phosphodiesterase inhibitor",-0.27053,-0.642,0.901,1409,0.991,"GSK256066",0.045275209020937,0.00392634551472468,FALSE +"HCC44","Pearson.est","PI3K inhibitor",0.35325,1,0.419,127,0.678,"CH5132799, BGT226, PI.828, PF.05212384, buparlisib, PI3K.IN.2, idelalisib, TG100.115",0.377785977033705,0.168770306132937,FALSE +"HCC44","Pearson.est","PLK inhibitor",-0.56493,-1.33,0.151,1114,0.536,"HMN.214, BI.2536, rigosertib, GSK461364",0.821023052706831,0.27083521030723,FALSE +"HCC44","Pearson.est","potassium channel blocker",0.32004,0.904,0.542,121,0.816,"dofetilide, ML133",0.266000713461613,0.0883098412461389,FALSE +"HCC44","Pearson.est","PPAR receptor agonist",0.34074,1.02,0.419,957,0.693,"pterostilbene, GW.501516, S26948, clofibrate, oleoylethanolamide, ciprofibrate, fenofibrate",0.377785977033705,0.159266765388193,FALSE +"HCC44","Pearson.est","progesterone receptor agonist",-0.30287,-0.731,0.809,942,0.964,"melengestrol.acetate, nomegestrol.acetate, norgestrel, norethindrone",0.0920514783877277,0.0159229660971692,FALSE +"HCC44","Pearson.est","proteasome inhibitor",-0.66369,-1.58,0.0321,1309,0.338,"ixazomib.citrate, ixazomib",1.49349496759513,0.471083299722345,FALSE +"HCC44","Pearson.est","protein synthesis inhibitor",-0.39729,-0.954,0.536,1292,0.842,"bruceantin, emetine, anguidine, cycloheximide, mercaptopurine",0.27083521030723,0.0746879085003505,FALSE +"HCC44","Pearson.est","protein tyrosine kinase inhibitor",-0.29837,-0.706,0.846,726,0.958,"NVP.TAE226, tyrphostin.A9, rheochrysidin, CP.724714, AV.412, PP.121",0.0726296369609765,0.0186344909214556,FALSE +"HCC44","Pearson.est","RAF inhibitor",0.48559,1.42,0.153,76,0.393,"dabrafenib, vemurafenib, GDC.0879",0.815308569182401,0.405607449624573,FALSE +"HCC44","Pearson.est","RET tyrosine kinase inhibitor",0.53259,1.52,0.0833,680,0.539,"apatinib, sorafenib, vandetanib, sunitinib, cabozantinib, regorafenib",1.07935499859321,0.268411234813261,FALSE +"HCC44","Pearson.est","retinoid receptor agonist",0.69273,2.04,0.0151,271,0.217,"tamibarotene, adarotene, fenretinide, CD.437, LE.135",1.82102305270683,0.66354026615147,TRUE +"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.3451,-0.818,0.704,759,0.953,"pentostatin, hydroxyurea, gemcitabine, fludarabine.phosphate, clofarabine, fludarabine",0.152427340857888,0.0209070993616736,FALSE +"HCC44","Pearson.est","serotonin receptor agonist",-0.66901,-1.6,0.0248,1447,0.437,"aripiprazole",1.60554831917378,0.359518563029578,FALSE +"HCC44","Pearson.est","serotonin receptor antagonist",-0.55731,-1.36,0.12,1334,0.571,"RS.16566, aripiprazole",0.920818753952375,0.243363891754152,FALSE +"HCC44","Pearson.est","sodium channel blocker",-0.22514,-0.542,0.969,809,1,"triamterene, oxcarbazepine, A.803467, ajmaline, quinidine, butamben",0.0136762229492347,0,FALSE +"HCC44","Pearson.est","src inhibitor",-0.39388,-0.937,0.569,1356,0.855,"bosutinib, KX2.391",0.244887733604929,0.0680338852718274,FALSE +"HCC44","Pearson.est","sterol demethylase inhibitor",-0.68037,-1.63,0.0303,1375,0.469,"ketoconazole, terconazole",1.5185573714977,0.328827157284917,FALSE +"HCC44","Pearson.est","TGF beta receptor inhibitor",-0.34333,-0.814,0.721,1353,0.938,"D.4476",0.142064735280571,0.0277971616209356,FALSE +"HCC44","Pearson.est","thymidylate synthase inhibitor",0.5111,1.44,0.103,711,0.437,"doxifluridine, capecitabine, raltitrexed, trifluridine, ftorafur, carmofur",0.987162775294828,0.359518563029578,FALSE +"HCC44","Pearson.est","topoisomerase inhibitor",-0.42232,-1.02,0.434,1073,0.789,"amsacrine, valrubicin, idarubicin, licochalcone.a, teniposide, TAS.103, voreloxin, amonafide",0.362510270487489,0.10292299679058,FALSE +"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.5844,-1.39,0.0847,905,0.581,"indibulin, oxibendazole, CYT.997, vinorelbine, podophyllotoxin, BNC105, dolastatin.10, docetaxel, parbendazole, vinblastine, albendazole, taltobulin, verubulin, plinabulin, combretastatin.A.4, flubendazole, ABT.751, nocodazole, KX2.391, epothilone.b, fosbretabulin, epothilone.d",1.07211658966929,0.235823867609669,FALSE +"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.31447,-0.762,0.779,1329,0.979,"aminopurvalanol.a, tyrphostin.AG.99, UNC2250",0.108462542327436,0.00921730819686218,FALSE +"HCC44","Pearson.est","VEGFR inhibitor",0.29217,0.84,0.607,77,0.786,"TG.100572, pazopanib, dovitinib, foretinib, PD.173074",0.216811308924742,0.104577453960592,FALSE +"HCC44","Pearson.est","vitamin D receptor agonist",0.30837,0.895,0.567,33,0.782,"maxacalcitol",0.246416941107093,0.106793246940152,FALSE +"H1703","Pearson.est","EGFR inhibitor",-0.29748,-0.728,0.796,796,0.856,"icotinib, neratinib, poziotinib, vandetanib, CP.724714, lapatinib, pelitinib, OSI.420, gefitinib, XL.647, TAK.285, canertinib, CGP.52411, GW.583340, AEE788, CNX.2006, PD.153035, rociletinib, WZ8040, ARRY.334543, salvianolic.acid.B, BIBX.1382, PD.168393, WZ.4002",0.0990869322623309,0.0675262353228468,FALSE +"H1703","Pearson.est","Abl kinase inhibitor",-0.4933,-1.23,0.234,763,0.505,"bafetinib, ponatinib, GZD824, nilotinib, ZM.306416, metatinib, flumatinib, KW.2449, bosutinib, imatinib, tozasertib",0.630784142589857,0.296708621881339,FALSE +"H1703","Pearson.est","acetylcholine receptor agonist",0.24549,0.683,0.851,1094,0.943,"pilocarpine, nefiracetam, xanomeline, nicotine, oxiracetam, tremorine",0.0700704399154121,0.0254883072626717,FALSE +"H1703","Pearson.est","acetylcholine receptor antagonist",0.66385,1.84,0.0222,349,0.211,"hyoscyamine, diphemanil, dicycloverine, methscopolamine, darifenacin",1.65364702554936,0.675717544702307,TRUE +"H1703","Pearson.est","adenosine receptor antagonist",0.41671,1.14,0.29,74,0.722,"SCH.58261, PSB.1115",0.537602002101044,0.141462802430361,FALSE +"H1703","Pearson.est","adrenergic receptor agonist",0.47441,1.37,0.153,348,0.426,"methyldopa, ritodrine, clenbuterol, norepinephrine, A61603, metaraminol, buphenine, terbutaline",0.815308569182401,0.370590400897281,FALSE +"H1703","Pearson.est","adrenergic receptor antagonist",0.27866,0.802,0.664,20,0.836,"propranolol, atenolol....",0.177831920631982,0.0777937225609836,FALSE +"H1703","Pearson.est","AKT inhibitor",-0.45839,-1.15,0.294,1012,0.567,"triciribine, uprosertib, A.674563, AZD5363, ONC201, CCT128930, AT7867",0.531652669587843,0.246416941107093,FALSE +"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.34833,-0.872,0.622,1166,0.735,"crizotinib, AP26113, AZD3463",0.206209615309181,0.133712660915805,FALSE +"H1703","Pearson.est","androgen receptor antagonist",0.52448,1.45,0.0841,357,0.496,"bicalutamide, RU.58841, enzalutamide, cyproterone.acetate",1.07520400420209,0.304518323509803,FALSE +"H1703","Pearson.est","antioxidant",-0.54797,-1.35,0.149,969,0.467,"benfotiamine, chlorogenic.acid, mesna, rutin, trolox",0.826813731587726,0.330683119433888,FALSE +"H1703","Pearson.est","AP inhibitor",0.62259,1.73,0.0645,70,0.252,"GDC.0152, tanshinone.i, birinapant",1.19044028536473,0.598599459218456,FALSE +"H1703","Pearson.est","ATPase inhibitor",-0.44219,-1.08,0.365,788,0.595,"digitoxigenin, thonzonium, rabeprazole, blebbistatin...., digitoxin, oligomycin.a, digoxin, omeprazole",0.437707135543525,0.22548303427145,FALSE +"H1703","Pearson.est","Aurora kinase inhibitor",-0.62915,-1.57,0.0499,951,0.379,"PHA.680632, CCT137690, MK.5108, KW.2449, GSK1070916, ZM.447439, barasertib, PF.03814735, MK.8745, alisertib, AMG900, danusertib, SNS.314, CCT129202, tozasertib, hesperadin, AT.9283, TAK.901, CYC116",1.30189945437661,0.421360790031928,FALSE +"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.42587,-1.05,0.394,1311,0.595,"azalomycin.b, valnemulin",0.404503778174426,0.22548303427145,FALSE +"H1703","Pearson.est","bacterial DNA gyrase inhibitor",0.66432,1.92,0.0128,277,0.427,"trovafloxacin, lomefloxacin, sarafloxacin, sparfloxacin, nadifloxacin, finafloxacin",1.89279003035213,0.369572124974976,FALSE +"H1703","Pearson.est","BCL inhibitor",-0.48724,-1.23,0.245,867,0.505,"TW.37, venetoclax, obatoclax, ABT.737, gossypol",0.610833915635468,0.296708621881339,FALSE +"H1703","Pearson.est","Bcr.Abl kinase inhibitor",-0.48607,-1.19,0.275,763,0.534,"bafetinib, ponatinib, GZD824, nilotinib, metatinib, flumatinib, bosutinib, imatinib, tozasertib",0.560667306169737,0.272458742971444,FALSE +"H1703","Pearson.est","benzodiazepine receptor agonist",0.55781,1.51,0.0805,202,0.483,"gamma.aminobutyric.acid, bentazepam, piperazine, eprinomectin, temazepam, CL.218872",1.09420411963213,0.316052869248488,FALSE +"H1703","Pearson.est","bromodomain inhibitor",-0.55414,-1.38,0.118,956,0.536,"JQ1...., OTX015, PFI.1, bromosporine",0.928117992693875,0.27083521030723,FALSE +"H1703","Pearson.est","calcium channel blocker",0.31123,0.878,0.598,105,0.775,"efonidipine.monoethanolate, SKF.96365",0.223298816011589,0.11069829749369,FALSE +"H1703","Pearson.est","CC chemokine receptor antagonist",0.31031,0.892,0.574,369,0.788,"ZK811752, RS.504393, PF.04136309, UNBS.5162",0.241088107602027,0.103473782510445,FALSE +"H1703","Pearson.est","CDK inhibitor",-0.62042,-1.57,0.0464,1279,0.379,"dinaciclib, JNJ.7706621, AT.7519, arcyriaflavin.a, PHA.793887, aminopurvalanol.a, abemaciclib, palbociclib, BMS.265246, ribociclib",1.33348201944512,0.421360790031928,FALSE +"H1703","Pearson.est","CHK inhibitor",-0.62168,-1.57,0.0522,1139,0.379,"LY2606368, LY2603618, SCH.900776, SB.218078",1.28232949699774,0.421360790031928,FALSE +"H1703","Pearson.est","cyclooxygenase inhibitor",-0.32176,-0.807,0.716,1188,0.783,"FR.122047, tepoxalin, curcumin, ketoprofen, acetylsalicylsalicylic.acid",0.145086977692144,0.106238237942057,FALSE +"H1703","Pearson.est","cytochrome P450 inhibitor",0.51747,1.42,0.118,94,0.408,"morin, PF.4981517",0.928117992693875,0.38933983691012,FALSE +"H1703","Pearson.est","DNA alkylating agent",-0.4152,-1.02,0.444,873,0.596,"carboplatin, satraplatin, melphalan, mitomycin.c, cyclophosphamide, TH.302, dianhydrogalactitol",0.35261702988538,0.224753740259764,FALSE +"H1703","Pearson.est","DNA inhibitor",-0.20202,-0.504,0.984,1004,0.993,"melphalan, oxaliplatin, chlorambucil, teroxirone, primaquine, pibenzimol",0.00700490156865849,0.00305075150461883,FALSE +"H1703","Pearson.est","DNA methyltransferase inhibitor",-0.61742,-1.55,0.0531,1186,0.33,"disulfiram, RG108, decitabine",1.27490547891853,0.481486060122112,FALSE +"H1703","Pearson.est","DNA polymerase inhibitor",0.37038,1.04,0.383,268,0.666,"famciclovir, foscarnet, menadione",0.416801226031377,0.176525770829699,FALSE +"H1703","Pearson.est","DNA synthesis inhibitor",-0.46225,-1.19,0.271,932,0.534,"nelarabine, CB.10.277, enocitabine, artesunate, mitomycin.c, azodicarbonamide, cyclocytidine, anisomycin",0.567030709125594,0.272458742971444,FALSE +"H1703","Pearson.est","dopamine receptor antagonist",0.27466,0.772,0.767,430,0.85,"clebopride, domperidone, thioproperazine, acetophenazine, sertindole, ziprasidone, remoxipride, UH.232...., isofloxythepin, lurasidone",0.115204636051019,0.0705810742857073,FALSE +"H1703","Pearson.est","estrogen receptor agonist",0.50152,1.42,0.123,313,0.408,"erteberel, ethinyl.estradiol, levonorgestrel, estradiol",0.910094888560602,0.38933983691012,FALSE +"H1703","Pearson.est","estrogen receptor antagonist",-0.37867,-0.945,0.539,939,0.639,"danazol, raloxifene, fulvestrant",0.268411234813261,0.1944991418416,FALSE +"H1703","Pearson.est","FGFR inhibitor",-0.40641,-1.02,0.441,1296,0.596,"AZD4547, nintedanib",0.355561410532161,0.224753740259764,FALSE +"H1703","Pearson.est","FLT3 inhibitor",-0.46753,-1.18,0.279,975,0.532,"tyrphostin.AG.1296, KW.2449, TG.101348, TG.02, sunitinib, quizartinib, midostaurin, tozasertib, lestaurtinib, pacritinib",0.554395796726402,0.274088367704952,FALSE +"H1703","Pearson.est","glucocorticoid receptor agonist",-0.4207,-1.05,0.413,760,0.595,"methylprednisolone, prednisolone.hemisuccinate, prednisolone, triamcinolone.acetonide, halobetasol.propionate, prednisolone.acetate, deflazacort, flumethasone.pivalate, difluprednate, triamcinolone, dexamethasone.acetate, rimexolone, desonide, clobetasol.propionate, fluorometholone, halcinonide, flumethasone, beclomethasone.dipropionate, fluocinolone.acetonide, fluticasone.propionate",0.384049948343599,0.22548303427145,FALSE +"H1703","Pearson.est","glutamate receptor antagonist",0.20445,0.578,0.927,395,0.942,"kynurenic.acid, diazooxonorleucine, JNJ.16259685, felbamate, CGP.37849, latrepirdine",0.0329202658555029,0.0259490972071227,FALSE +"H1703","Pearson.est","glycogen synthase kinase inhibitor",-0.32743,-0.822,0.678,714,0.777,"GSK.3.inhibitor.IX, tideglusib, TWS.119, indirubin, LY2090314, AZD2858",0.168770306132937,0.109578981199086,FALSE +"H1703","Pearson.est","growth factor receptor inhibitor",-0.66629,-1.66,0.033,1098,0.488,"PHA.848125, danusertib, AZD3463, lestaurtinib",1.48148606012211,0.311580177997289,FALSE +"H1703","Pearson.est","HCV inhibitor",0.38311,1.06,0.363,161,0.671,"daclatasvir, PSI.7976",0.440093374963888,0.173277479831008,FALSE +"H1703","Pearson.est","HDAC inhibitor",-0.66207,-1.64,0.0344,1124,0.425,"scriptaid, SB.939, PCI.24781, trichostatin.a, romidepsin, chidamide, mocetinostat, belinostat, vorinostat, M.344, entinostat, RG2833, resminostat, givinostat, dacinostat, AR.42, ACY.1215",1.46344155742847,0.371611069949688,FALSE +"H1703","Pearson.est","histamine receptor antagonist",0.22612,0.608,0.886,284,0.952,"chloropyramine, famotidine, terfenadine, ranitidine, cyproheptadine, epinastine, zolantidine, cimetidine",0.0525662781129492,0.0213630516155257,FALSE +"H1703","Pearson.est","HMGCR inhibitor",-0.53486,-1.32,0.168,1386,0.448,"simvastatin",0.774690718274137,0.348721986001856,FALSE +"H1703","Pearson.est","HSP inhibitor",-0.54803,-1.38,0.112,879,0.536,"NMS.E973, XL888, PU.H71, BIIB021, SNX.2112, alvespimycin, NVP.AUY922, VER.49009, tanespimycin, ganetespib",0.950781977329818,0.27083521030723,FALSE +"H1703","Pearson.est","JAK inhibitor",-0.52109,-1.31,0.178,1378,0.444,"tozasertib, AZ960, AT.9283, PRT062070, lestaurtinib, pacritinib",0.749579997691106,0.35261702988538,FALSE +"H1703","Pearson.est","KIT inhibitor",-0.38699,-0.976,0.476,1195,0.636,"masitinib, sunitinib, telatinib, imatinib, midostaurin, vatalanib",0.322393047279507,0.196542884351586,FALSE +"H1703","Pearson.est","MDM inhibitor",-0.71857,-1.79,0.013,1225,0.268,"AMG.232, idasanutlin, RITA, CGM097",1.88605664769316,0.571865205971211,FALSE +"H1703","Pearson.est","MEK inhibitor",-0.44864,-1.12,0.34,1009,0.579,"cobimetinib, MEK162, arctigenin, trametinib, PD.184352, Ro.4987655, AS.703026, selumetinib, AZD8330, TAK.733, refametinib, nobiletin",0.468521082957745,0.237321436272564,FALSE +"H1703","Pearson.est","MET inhibitor",-0.53999,-1.36,0.126,902,0.506,"PHA.665752, AMG458, NVP.BVU972",0.899629454882437,0.295849483160201,FALSE +"H1703","Pearson.est","microtubule inhibitor",-0.53803,-1.34,0.163,910,0.437,"vinflunine, colchicine, secnidazole, cytochalasin.b, D.64131, cabazitaxel",0.787812395596042,0.359518563029578,FALSE +"H1703","Pearson.est","mTOR inhibitor",-0.1493,-0.377,0.999,212,0.998,"AZD8055, PP242, PI.103, palomid.529, everolimus, deforolimus, LY3023414, temsirolimus, voxtalisib, torin.2, torin.1, WYE.125132, WAY.600, OSI.027, PKI.179, MLN0128, ku.0063794, GDC.0980, sirolimus, XL388, GSK2126458, AZD2014, PF.04691502, NVP.BEZ235, LY303511, SB.2343, PF.05212384, WYE.354",0.000434511774017692,0.000869458712628891,FALSE +"H1703","Pearson.est","NFkB pathway inhibitor",-0.45352,-1.11,0.318,1234,0.561,"betulinic.acid, curcumin, Ro.106.9920",0.497572880015567,0.251037138743839,FALSE +"H1703","Pearson.est","opioid receptor agonist",-0.32203,-0.804,0.724,1315,0.771,"salvinorin.a",0.140261433802853,0.112945621949043,FALSE +"H1703","Pearson.est","p38 MAPK inhibitor",0.28586,0.803,0.673,331,0.873,"SB.242235, TAK.715, SB.239063",0.171984935776023,0.0589857562944303,FALSE +"H1703","Pearson.est","PARP inhibitor",-0.49584,-1.24,0.224,947,0.531,"endo.IWR.1, talazoparib, niraparib, AZD2461",0.649751981665837,0.274905478918531,FALSE +"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.42906,-1.05,0.401,1158,0.595,"trapidil, masitinib, sunitinib, telatinib, crenolanib, imatinib, axitinib, vatalanib, nintedanib",0.396855627379818,0.22548303427145,FALSE +"H1703","Pearson.est","phosphatase inhibitor",0.23721,0.674,0.848,268,0.918,"alexidine, sodium.stibogluconate, mycophenolate.mofetil, menadione",0.0716041477432862,0.0371573187987575,FALSE +"H1703","Pearson.est","phosphodiesterase inhibitor",0.35317,0.975,0.438,102,0.749,"avanafil, cilostamide",0.3585258894959,0.125518182300534,FALSE +"H1703","Pearson.est","PI3K inhibitor",-0.27303,-0.683,0.849,865,0.892,"PF.04691502, TG.100713, GDC.0941, NVP.BEZ235, CH5132799, LY303511, taselisib, alpelisib, ZSTK.474, SB.2343, pilaralisib, PF.05212384, CUDC.907, YM.201636, PIK.75",0.0710923097560473,0.0496351456238769,FALSE +"H1703","Pearson.est","PLK inhibitor",-0.6063,-1.49,0.0725,937,0.378,"NMS.1286937, volasertib, GW.843682X, BI.2536, rigosertib, GSK461364",1.13966199342901,0.422508200162775,FALSE +"H1703","Pearson.est","potassium channel blocker",0.38707,1.1,0.303,394,0.692,"meglitinide, ibutilide, dofetilide, ML133, oleoylethanolamide",0.518557371497695,0.159893905543242,FALSE +"H1703","Pearson.est","PPAR receptor agonist",0.40736,1.12,0.303,861,0.706,"pterostilbene, ciprofibrate, oleoylethanolamide, GW.501516, fenofibrate, clofibrate, S26948",0.518557371497695,0.151195298948196,FALSE +"H1703","Pearson.est","progesterone receptor agonist",0.47706,1.31,0.149,207,0.466,"dienogest, norethindrone.acetate, levonorgestrel",0.826813731587726,0.33161408331,FALSE +"H1703","Pearson.est","proteasome inhibitor",-0.53882,-1.36,0.144,809,0.506,"bortezomib, ONX.0914, oprozomib, ixazomib.citrate, carfilzomib, ixazomib",0.84163750790475,0.295849483160201,FALSE +"H1703","Pearson.est","protein synthesis inhibitor",-0.4479,-1.11,0.341,1175,0.561,"thiostrepton, mercaptopurine, cycloheximide, bruceantin, harringtonine, emetine, homoharringtonine",0.467245621007502,0.251037138743839,FALSE +"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.45099,-1.12,0.349,711,0.579,"NVP.TAE226, mubritinib, CP.724714, AV.412, tyrphostin.A9, PP.121, rheochrysidin",0.45717457304082,0.237321436272564,FALSE +"H1703","Pearson.est","RAF inhibitor",-0.33228,-0.822,0.685,981,0.777,"regorafenib, CEP.32496, LGX818, TAK.632, AZ.628",0.164309428507574,0.109578981199086,FALSE +"H1703","Pearson.est","RET tyrosine kinase inhibitor",-0.54122,-1.35,0.129,832,0.467,"vandetanib, regorafenib, sunitinib, cabozantinib",0.889410289700751,0.330683119433888,FALSE +"H1703","Pearson.est","retinoid receptor agonist",0.65065,1.86,0.00694,51,0.289,"adarotene, tamibarotene, adapalene",2.15864052954515,0.539102157243452,FALSE +"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.62561,-1.56,0.0523,1181,0.351,"pentostatin, gemcitabine, clofarabine, fludarabine",1.28149831113273,0.454692883534176,FALSE +"H1703","Pearson.est","serotonin receptor agonist",0.38751,1.07,0.341,170,0.697,"NAN.190, SR.57227A",0.467245621007502,0.156767221901991,FALSE +"H1703","Pearson.est","serotonin receptor antagonist",0.32067,0.896,0.528,372,0.867,"SB.200646, sertindole, ziprasidone, pirenperone, tropisetron, lerisetron",0.277366077466188,0.0619809025237897,FALSE +"H1703","Pearson.est","sodium channel blocker",0.32367,0.895,0.55,168,0.824,"ajmaline, brivaracetam, benzethonium, A.803467",0.259637310505756,0.0840727883028842,FALSE +"H1703","Pearson.est","src inhibitor",-0.39011,-0.978,0.479,936,0.648,"ZM.306416, saracatinib, masitinib, KX2.391, bosutinib",0.319664486585437,0.188424994129407,FALSE +"H1703","Pearson.est","sterol demethylase inhibitor",-0.61284,-1.53,0.0578,1437,0.333,"ketoconazole",1.23807216157947,0.47755576649368,FALSE +"H1703","Pearson.est","TGF beta receptor inhibitor",-0.41387,-1.03,0.412,967,0.611,"SB.525334, SB.431542, repsox",0.385102783966865,0.213958789757446,FALSE +"H1703","Pearson.est","thymidylate synthase inhibitor",-0.39079,-0.961,0.503,670,0.63,"raltitrexed, capecitabine, doxifluridine, carmofur",0.298432014944073,0.200659450546418,FALSE +"H1703","Pearson.est","topoisomerase inhibitor",-0.53938,-1.34,0.158,1152,0.437,"mitoxantrone, fleroxacin, etoposide, amsacrine, licochalcone.a, daunorubicin, TAS.103, SN.38, voreloxin, camptothecin, amonafide, teniposide",0.801342913045577,0.359518563029578,FALSE +"H1703","Pearson.est","tubulin polymerization inhibitor",-0.51685,-1.3,0.171,988,0.442,"flubendazole, ABT.751, vindesine, verubulin, dolastatin.10, CYT.997, oxibendazole, parbendazole, docetaxel, KX2.391, fosbretabulin, combretastatin.A.4, epothilone.b, epothilone.d, plinabulin",0.767003889607846,0.354577730650908,FALSE +"H1703","Pearson.est","tyrosine kinase inhibitor",-0.38823,-0.969,0.494,981,0.632,"regorafenib, AV.412, tyrphostin.A9, PP.121, rheochrysidin, sunitinib, cabozantinib, AMG.208, UNC2250, aminopurvalanol.a, tyrphostin.AG.99",0.306273051076353,0.199282921717615,FALSE +"H1703","Pearson.est","VEGFR inhibitor",-0.24131,-0.605,0.902,1198,0.951,"sunitinib, cabozantinib, telatinib, axitinib, vatalanib, nintedanib",0.0447934624580583,0.0218194830625861,FALSE +"H1703","Pearson.est","vitamin D receptor agonist",-0.76748,-1.94,0,1187,0.119,"maxacalcitol, paricalcitol, calcitriol, alfacalcidol, doxercalciferol, tacalcitol",Inf,0.924453038607469,TRUE +"H1299","Pearson.est","EGFR inhibitor",-0.26174,-0.626,0.928,731,1,"OSI.420, dovitinib, AST.1306, afatinib, XL.647, ARRY.334543, vandetanib, TAK.285, rociletinib, pelitinib, PD.153035, BIBU.1361, CUDC.101, dacomitinib, BMS.599626, CP.724714, FERb.033, neratinib, salvianolic.acid.B, tucatinib",0.0324520237811379,0,FALSE +"H1299","Pearson.est","Abl kinase inhibitor",-0.67294,-1.63,0.0152,1194,0.365,"imatinib, nilotinib, bosutinib, KW.2449, tozasertib, ponatinib, flumatinib",1.81815641205523,0.437707135543525,FALSE +"H1299","Pearson.est","acetylcholine receptor agonist",-0.48333,-1.17,0.259,768,0.499,"nefiracetam, xanomeline, oxiracetam, tremorine, pilocarpine",0.586700235918748,0.30189945437661,FALSE +"H1299","Pearson.est","acetylcholine receptor antagonist",-0.52439,-1.26,0.183,853,0.478,"diphemanil, iododexetimide, dicycloverine, methscopolamine",0.737548910269571,0.320572103387881,FALSE +"H1299","Pearson.est","adenosine receptor antagonist",-0.49567,-1.18,0.249,841,0.493,"theophylline, istradefylline, PSB.1115, sulmazole",0.603800652904264,0.30715308072277,FALSE +"H1299","Pearson.est","adrenergic receptor agonist",-0.44538,-1.07,0.373,1133,0.641,"oxymetazoline, epinephrine, isoetharine, clenbuterol, midodrine",0.428291168191312,0.193141970481183,FALSE +"H1299","Pearson.est","adrenergic receptor antagonist",-0.19694,-0.477,0.986,507,1,"RS.17053, dronedarone, prazosin, atipamezole, dihydroergocristine, atenolol......, naftidrofuryl, levobunolol, vincamine, imiloxan, propranolol, oxprenolol, pindolol, carvedilol, atenolol...., idazoxan",0.0061230850587888,0,FALSE +"H1299","Pearson.est","AKT inhibitor",-0.57258,-1.38,0.0951,1263,0.341,"palomid.529, uprosertib, CCT128930, AT7867",1.02181948306259,0.467245621007502,FALSE +"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.25713,-0.624,0.917,839,1,"alectinib, AP26113, CEP.37440, AZD3463, DMH1",0.0376306643299789,0,FALSE +"H1299","Pearson.est","androgen receptor antagonist",-0.52466,-1.25,0.186,1225,0.451,"bicalutamide, flutamide",0.730487055782084,0.345823458122039,FALSE +"H1299","Pearson.est","antioxidant",-0.52653,-1.25,0.194,849,0.451,"chlorogenic.acid, mesna, trolox, taurine, benfotiamine",0.712198270069774,0.345823458122039,FALSE +"H1299","Pearson.est","AP inhibitor",0.45684,1.41,0.0992,146,1,"birinapant, tanshinone.i, GDC.0152",1.00348832784582,0,FALSE +"H1299","Pearson.est","ATPase inhibitor",0.31584,0.963,0.503,47,0.691,"k.strophanthidin, thonzonium",0.298432014944073,0.160521952625802,FALSE +"H1299","Pearson.est","Aurora kinase inhibitor",-0.56818,-1.38,0.0971,1131,0.341,"CCT129202, CCT137690, barasertib.HQPA, barasertib, MK.8745, hesperadin, KW.2449, alisertib, tozasertib, ZM.447439, danusertib, SNS.314, ENMD.2076, AT.9283",1.012780770092,0.467245621007502,FALSE +"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.67192,-1.62,0.0234,1000,0.262,"tedizolid, radezolid, valnemulin, josamycin, dirithromycin, tilmicosin, azalomycin.b",1.63078414258986,0.581698708680255,FALSE +"H1299","Pearson.est","bacterial DNA gyrase inhibitor",0.38017,1.2,0.194,203,0.566,"lomefloxacin, sparfloxacin, nadifloxacin",0.712198270069774,0.247183568811729,FALSE +"H1299","Pearson.est","BCL inhibitor",-0.3934,-0.947,0.546,843,0.813,"gossypol, obatoclax, TW.37, venetoclax",0.262807357295263,0.0899094544059319,FALSE +"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.68093,-1.63,0.0245,1194,0.365,"imatinib, nilotinib, bosutinib, tozasertib, ponatinib, flumatinib",1.61083391563547,0.437707135543525,FALSE +"H1299","Pearson.est","benzodiazepine receptor agonist",0.23484,0.705,0.821,1111,0.928,"gamma.aminobutyric.acid, ivermectin, bentazepam, eprinomectin, indiplon, zaleplon, CL.218872, ZK.93423, temazepam, nefiracetam, CGS.20625, lorazepam, piperazine",0.0856568428805592,0.0324520237811379,FALSE +"H1299","Pearson.est","bromodomain inhibitor",-0.82247,-1.96,0.0023,1186,0.0435,"OTX015, I.BET151, I.BET.762, PFI.1, bromosporine, JQ1....",2.63827216398241,1.36151074304536,TRUE +"H1299","Pearson.est","calcium channel blocker",-0.36033,-0.877,0.639,818,0.855,"tetrandrine, carboxyamidotriazole, cinnarazine, mibefradil, pranidipine",0.1944991418416,0.0680338852718274,FALSE +"H1299","Pearson.est","CC chemokine receptor antagonist",-0.32807,-0.791,0.772,926,0.938,"PF.04136309, SB.225002, RS.504393, MK.0812",0.112382699664264,0.0277971616209356,FALSE +"H1299","Pearson.est","CDK inhibitor",-0.61917,-1.47,0.0659,1125,0.355,"BMS.265246, indisulam, R547, P276.00, AZD5438, PHA.793887, AT.7519, JNJ.7706621, PHA.848125, BMS.387032, aminopurvalanol.a, TG.02, palbociclib, ribociclib, dinaciclib, abemaciclib",1.18111458540599,0.449771646944906,FALSE +"H1299","Pearson.est","CHK inhibitor",-0.36118,-0.87,0.654,1399,0.837,"SB.218078",0.184422251675733,0.07727454200674,FALSE +"H1299","Pearson.est","cyclooxygenase inhibitor",-0.39141,-0.943,0.555,1190,0.805,"acetylsalicylsalicylic.acid, FR.122047, ketoprofen, aspirin, piroxicam, phenazone",0.255707016877324,0.0942041196321315,FALSE +"H1299","Pearson.est","cytochrome P450 inhibitor",-0.4425,-1.07,0.37,671,0.641,"clotrimazole, morin, PF.4981517, itraconazole, cobicistat, eplerenone",0.431798275933005,0.193141970481183,FALSE +"H1299","Pearson.est","DNA alkylating agent",-0.36108,-0.875,0.645,1285,0.843,"temozolomide, TH.302, estramustine",0.190440285364732,0.0741724253752577,FALSE +"H1299","Pearson.est","DNA inhibitor",-0.14695,-0.357,0.998,1407,1,"primaquine",0.000869458712628891,0,FALSE +"H1299","Pearson.est","DNA methyltransferase inhibitor",-0.63776,-1.53,0.0318,1249,0.414,"RG108, decitabine, SGI.1027",1.49757288001557,0.382999658879101,FALSE +"H1299","Pearson.est","DNA polymerase inhibitor",-0.61714,-1.5,0.0457,1389,0.354,"trifluridine, idoxuridine",1.34008379993015,0.450996737974212,FALSE +"H1299","Pearson.est","DNA synthesis inhibitor",-0.19491,-0.475,0.991,730,1,"artesunate, anisomycin, cyclocytidine, mitomycin.c, enocitabine, CB.10.277, azodicarbonamide, capecitabine",0.00392634551472468,0,FALSE +"H1299","Pearson.est","dopamine receptor antagonist",-0.28311,-0.678,0.869,1068,1,"sertindole, mesoridazine, ziprasidone, UH.232...., raclopride, paliperidone",0.0609802235513335,0,FALSE +"H1299","Pearson.est","estrogen receptor agonist",-0.42809,-1.04,0.421,963,0.678,"estradiol, estradiol.cypionate, estrone, PPT",0.375717904164332,0.168770306132937,FALSE +"H1299","Pearson.est","estrogen receptor antagonist",-0.68337,-1.66,0.0207,1411,0.586,"clomifene, tamoxifen",1.68402965454308,0.232102383981909,FALSE +"H1299","Pearson.est","FGFR inhibitor",-0.41503,-1.01,0.463,1287,0.726,"nintedanib, regorafenib, lucitanib",0.334419008982047,0.139063379299906,FALSE +"H1299","Pearson.est","FLT3 inhibitor",-0.56028,-1.35,0.0959,1023,0.348,"quizartinib, gilteritinib, sorafenib, lestaurtinib, KW.2449, pacritinib, tandutinib, tozasertib, TG.02, ponatinib, ENMD.2076",1.01818139282934,0.458420756053419,FALSE +"H1299","Pearson.est","glucocorticoid receptor agonist",-0.27774,-0.664,0.901,989,1,"halobetasol.propionate, fluocinolone.acetonide, flumethasone.pivalate, fluticasone.propionate, methylprednisolone, flumethasone, difluprednate, halcinonide, prednisolone, betamethasone",0.045275209020937,0,FALSE +"H1299","Pearson.est","glutamate receptor antagonist",-0.22613,-0.541,0.95,1098,1,"tiletamine, IEM1754, JNJ.16259685",0.0222763947111523,0,FALSE +"H1299","Pearson.est","glycogen synthase kinase inhibitor",0.30021,0.928,0.568,1016,0.661,"CHIR.98014, AZD2858, TWS.119, tideglusib, GSK.3.inhibitor.IX, indirubin, LY2090314, CHIR.99021, kenpaullone",0.245651664288981,0.17979854051436,FALSE +"H1299","Pearson.est","growth factor receptor inhibitor",-0.62941,-1.52,0.0498,1154,0.389,"lestaurtinib, AZD3463, danusertib, PHA.848125, GSK1838705A",1.30277065724028,0.410050398674292,FALSE +"H1299","Pearson.est","HCV inhibitor",-0.5684,-1.37,0.0906,1362,0.327,"mericitabine, narlaprevir",1.04287180232319,0.485452247339714,FALSE +"H1299","Pearson.est","HDAC inhibitor",-0.41596,-0.991,0.487,988,0.752,"ACY.1215, AR.42, R306465, RGFP966, givinostat, belinostat, resminostat, vorinostat, trichostatin.a, dacinostat, M.344, RG2833",0.312471038785366,0.123782159408358,FALSE +"H1299","Pearson.est","histamine receptor antagonist",-0.43323,-1.05,0.413,942,0.672,"pheniramine, levocetirizine, lafutidine, BF2.649, cimetidine, nizatidine, ICI.162846, tiotidine, ebastine",0.384049948343599,0.172630726946175,FALSE +"H1299","Pearson.est","HMGCR inhibitor",0.41262,1.34,0.0916,853,0.459,"mevastatin, fluvastatin, simvastatin, lovastatin, pitavastatin, atorvastatin",1.03810452633215,0.338187314462739,FALSE +"H1299","Pearson.est","HSP inhibitor",-0.57625,-1.39,0.0955,888,0.357,"KW.2478, guanidine, VER.49009, BIIB021, NMS.E973, PU.H71, tanespimycin, ganetespib, alvespimycin, NVP.AUY922, SNX.5422, XL888",1.01999662841625,0.447331783887807,FALSE +"H1299","Pearson.est","JAK inhibitor",-0.59818,-1.44,0.066,1102,0.394,"AZD1480, AZ960, baricitinib, lestaurtinib, TG.101209, filgotinib, pacritinib, tozasertib, PRT062070, TG.02, AT.9283",1.18045606445813,0.404503778174426,FALSE +"H1299","Pearson.est","KIT inhibitor",-0.51484,-1.25,0.187,1099,0.451,"OSI.930, sorafenib, imatinib, tandutinib, vatalanib, regorafenib, telatinib, masitinib",0.728158393463501,0.345823458122039,FALSE +"H1299","Pearson.est","MDM inhibitor",-0.62169,-1.51,0.0468,1171,0.37,"nutlin.3, CGM097",1.32975414692588,0.431798275933005,FALSE +"H1299","Pearson.est","MEK inhibitor",-0.14549,-0.348,1,716,0.999,"PD.0325901, AS.703026, cobimetinib, arctigenin, selumetinib, trametinib, nobiletin",0,0.000434511774017692,FALSE +"H1299","Pearson.est","MET inhibitor",-0.34312,-0.829,0.702,1281,0.893,"AMG458",0.153662887870195,0.0491485411114536,FALSE +"H1299","Pearson.est","microtubule inhibitor",-0.50611,-1.22,0.214,1253,0.466,"cytochalasin.b, secnidazole, D.64131",0.669586226650809,0.33161408331,FALSE +"H1299","Pearson.est","mTOR inhibitor",0.33839,1.03,0.43,104,0.661,"SB.2343, sirolimus, WAY.600, PP242, torin.1, deforolimus, PF.05212384",0.366531544420413,0.17979854051436,FALSE +"H1299","Pearson.est","NFkB pathway inhibitor",-0.28086,-0.681,0.88,871,1,"Ro.106.9920, EVP4593, bortezomib, IKK.2.inhibitor.V, betulinic.acid",0.0555173278498314,0,FALSE +"H1299","Pearson.est","opioid receptor agonist",-0.67293,-1.62,0.0219,1380,0.262,"salvinorin.a, trimebutine",1.65955588515988,0.581698708680255,FALSE +"H1299","Pearson.est","p38 MAPK inhibitor",-0.54933,-1.32,0.126,865,0.389,"SB.242235, talmapimod, SB.239063, skepinone.l, VX.702",0.899629454882437,0.410050398674292,FALSE +"H1299","Pearson.est","PARP inhibitor",-0.45596,-1.09,0.354,828,0.625,"AZD2461, PJ.34, niraparib, AG.14361, E7449, talazoparib",0.450996737974212,0.204119982655925,FALSE +"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.57578,-1.39,0.0906,1122,0.357,"sorafenib, trapidil, imatinib, tandutinib, nintedanib, vatalanib, regorafenib, axitinib, ponatinib, telatinib, CP.673451, crenolanib, masitinib",1.04287180232319,0.447331783887807,FALSE +"H1299","Pearson.est","phosphatase inhibitor",-0.37334,-0.903,0.624,1435,0.837,"CID.5458317",0.204815410317576,0.07727454200674,FALSE +"H1299","Pearson.est","phosphodiesterase inhibitor",-0.49873,-1.2,0.234,1038,0.479,"EMD.53998, trequinsin, cilostamide, GSK256066",0.630784142589857,0.319664486585437,FALSE +"H1299","Pearson.est","PI3K inhibitor",-0.15449,-0.369,1,1303,1,"PIK.75, LY303511",0,0,FALSE +"H1299","Pearson.est","PLK inhibitor",-0.60423,-1.49,0.0559,905,0.343,"GW.843682X, NMS.1286937, GSK461364, BI.2536, rigosertib, volasertib",1.25258819211358,0.464705879957229,FALSE +"H1299","Pearson.est","potassium channel blocker",-0.47388,-1.13,0.299,1347,0.553,"mepivacaine",0.52432881167557,0.257274868695302,FALSE +"H1299","Pearson.est","PPAR receptor agonist",0.44451,1.35,0.109,154,0.665,"pterostilbene, clofibrate, GW.501516",0.962573502059376,0.177178354696895,FALSE +"H1299","Pearson.est","progesterone receptor agonist",0.18207,0.54,0.961,1186,0.97,"levonorgestrel, norethindrone.acetate, norethindrone, tanaproget, dienogest, norgestrel, melengestrol.acetate, danazol, nomegestrol.acetate",0.0172766123314547,0.0132282657337552,FALSE +"H1299","Pearson.est","proteasome inhibitor",-0.4746,-1.16,0.289,907,0.506,"MG.132, carfilzomib, ixazomib, bortezomib, ixazomib.citrate",0.539102157243452,0.295849483160201,FALSE +"H1299","Pearson.est","protein synthesis inhibitor",-0.24067,-0.576,0.951,1120,1,"thiostrepton, harringtonine, bruceantin, anguidine, puromycin",0.0218194830625861,0,FALSE +"H1299","Pearson.est","protein tyrosine kinase inhibitor",-0.52047,-1.24,0.184,1049,0.442,"BMS.599626, rheochrysidin, CP.724714, AV.412",0.735182176990464,0.354577730650908,FALSE +"H1299","Pearson.est","RAF inhibitor",-0.58608,-1.41,0.0848,1021,0.434,"PLX.4720, dabrafenib, sorafenib, RAF265, GDC.0879, AZ.628, regorafenib, TAK.632",1.07160414774329,0.362510270487489,FALSE +"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.51143,-1.21,0.219,749,0.474,"cabozantinib, sunitinib, vandetanib, sorafenib, regorafenib",0.659555885159882,0.324221658325915,FALSE +"H1299","Pearson.est","retinoid receptor agonist",0.35069,1.06,0.348,166,0.723,"adapalene, LE.135, CD.437",0.458420756053419,0.140861702705469,FALSE +"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.59172,-1.4,0.0931,980,0.402,"cladribine, pentostatin, hydroxyurea, fludarabine, clofarabine, fludarabine.phosphate",1.03105031901866,0.39577394691553,FALSE +"H1299","Pearson.est","serotonin receptor agonist",-0.56197,-1.37,0.108,1134,0.327,"zolmitriptan, aripiprazole, ipsapirone",0.96657624451305,0.485452247339714,FALSE +"H1299","Pearson.est","serotonin receptor antagonist",-0.51954,-1.24,0.183,981,0.442,"SB.228357, sertindole, ziprasidone, aripiprazole, paliperidone, RS.16566, SB.216641",0.737548910269571,0.354577730650908,FALSE +"H1299","Pearson.est","sodium channel blocker",-0.32831,-0.781,0.775,1130,0.938,"triamterene, oxcarbazepine, mepivacaine, quinidine",0.11069829749369,0.0277971616209356,FALSE +"H1299","Pearson.est","src inhibitor",-0.52495,-1.27,0.17,1226,0.475,"KX2.391, bosutinib, PP.1, masitinib",0.769551078621726,0.323306390375133,FALSE +"H1299","Pearson.est","sterol demethylase inhibitor",-0.36286,-0.878,0.627,883,0.869,"ketoconazole, chlormidazole, posaconazole",0.202732459169284,0.0609802235513335,FALSE +"H1299","Pearson.est","TGF beta receptor inhibitor",-0.57317,-1.39,0.0936,1295,0.357,"LY2109761, D.4476",1.02872415126189,0.447331783887807,FALSE +"H1299","Pearson.est","thymidylate synthase inhibitor",-0.57902,-1.4,0.103,961,0.402,"raltitrexed, carmofur, capecitabine, trifluridine",0.987162775294828,0.39577394691553,FALSE +"H1299","Pearson.est","topoisomerase inhibitor",-0.20093,-0.489,0.979,588,1,"idarubicin, amsacrine, irinotecan, camptothecin, TAS.103, genz.644282, SN.38, dexrazoxane, etoposide, licochalcone.a, valrubicin, teniposide, exatecan.mesylate, fleroxacin, etoposide.phosphate, amonafide, daunorubicin",0.00921730819686218,0,FALSE +"H1299","Pearson.est","tubulin polymerization inhibitor",-0.49628,-1.18,0.24,872,0.493,"vinblastine, nocodazole, epothilone.b, verubulin, plinabulin, flubendazole, vincristine, taltobulin, vindesine, vinorelbine, KX2.391, ABT.751, parbendazole, combretastatin.A.4, docetaxel, albendazole, paclitaxel, fosbretabulin",0.619788758288394,0.30715308072277,FALSE +"H1299","Pearson.est","tyrosine kinase inhibitor",-0.38829,-0.941,0.533,728,0.793,"bafetinib, cabozantinib, sunitinib, vandetanib, AMG.208, hypericin, BMS.599626, rheochrysidin, UNC2250, CP.724714, sorafenib, AV.412, regorafenib, aminopurvalanol.a, tivantinib",0.273272790973428,0.100726812682396,FALSE +"H1299","Pearson.est","VEGFR inhibitor",-0.3965,-0.965,0.527,722,0.79,"cediranib, dovitinib, XL.647, cabozantinib, SAR131675, sunitinib, MK.2461, pazopanib, vandetanib, KI.8751, PD.173074, TG.100572, OSI.930, sorafenib, RAF265, tivozanib, nintedanib, foretinib, vatalanib, regorafenib, axitinib, telatinib, golvatinib, lucitanib, ENMD.2076",0.278189384787453,0.102372908709559,FALSE +"H1299","Pearson.est","vitamin D receptor agonist",-0.37323,-0.905,0.6,1074,0.849,"doxercalciferol, alfacalcidol, tacalcitol",0.221848749616356,0.0710923097560473,FALSE diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_venn_diagram.pdf b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_venn_diagram.pdf new file mode 100644 index 0000000000000000000000000000000000000000..458efd769483a777650faee25af2f30db514ed0b GIT binary patch literal 7599 zcmZ{pbzIYH`^O0Z9Vjg+3*vC$GDt$=jr9HU{tHl({t5u_xg1Vvf|VRTD}pa@7y zcgJsdj^~``Ilt%o*Y4}S>b~~R^?rTW)#Vg;!F+-McK;dwS^qx&A!8Q+7|0JqJh25x zNB}^xE^sKy2H_|NMZtlba`zzo5J7%0SOmf^C?o{t0)SKz7XR~3+XiKijnV`vx;m#vH$afKyAvD; zl7*t6_6RE=NF8bgM*;<~4w}Hf14RB6aOrpH?E-g1{pk*pML43cM!BtIVqGjc}jur@Nngw*){{})pYh4zx9vpx~#9Y)unaf8LJg$2oW$NcEo{8v@(qaJec<#g@n z)VutqRt}8qqPM1wiuXJ>tXfY;`!vNqxQ;r@JuA2KDWHGm;@Vq9ZM8=GY)CNuvFwvJ zgOBOg#TnXnqFS9ni~6GXFm@Aw>(RkS6Mg1m){49(dN8w8Gv(Cxdn8joiUxa~qKP?1 z2m9V{Bz+Y1O(mxVEp9X3s|qw2+FKa~GxGXQJf3~B`F)ajvbDcg10I1K8>D=j5qMXR zHXslh*jrpV_&#Yi_1KX1Tc*fT!cs)j66$7%Ghyn)mugX(#^l4VY481?eKDBUTuo$= 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+
+
+ + + + diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_mean_results.csv b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_mean_results.csv new file mode 100644 index 0000000..8dcb4e1 --- /dev/null +++ b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_mean_results.csv @@ -0,0 +1,3 @@ +"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"alpha amino acids",0.0415,1.15505777937046,0.166152839512075,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H520",0.166152839512075 +"acyl carnitines",-0.2254,1.32928787425131,0.00108227266904627,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"H2126, HCC2279, H460",0.00216454533809254 diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_results.csv b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_results.csv new file mode 100644 index 0000000..520d7c9 --- /dev/null +++ b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_results.csv @@ -0,0 +1,41 @@ +"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"H358","Input","alpha amino acids",-0.28972,-1.01,0.427,62,0.435,"sarcosine, homocysteine, glycine, citrulline, dimethylglycine, creatinine, betaine, acetylglycine, ornithine, phosphocreatine, creatine",0.369572124974976,0.361510743045363,FALSE +"H358","Input","acyl carnitines",-0.38991,-1.41,0.119,85,0.227,"propionylcarnitine, heptanoylcarnitine, stearoylcarnitine, malonylcarnitine, hexanoylcarnitine, palmitoylcarnitine, myristoylcarnitine",0.924453038607469,0.643974142806877,FALSE +"H1650","Input","alpha amino acids",-0.41638,-1.49,0.0853,173,0.1,"glycine, creatinine, betaine, ornithine, dimethylglycine, creatine, citrulline",1.06905096883248,1,FALSE +"H1650","Input","acyl carnitines",0.36239,1.24,0.191,146,0.195,"hexanoylcarnitine, myristoylcarnitine, heptanoylcarnitine, malonylcarnitine, palmitoylcarnitine, stearoylcarnitine, propionylcarnitine",0.718966632752272,0.709965388637482,FALSE +"HCC95","Input","alpha amino acids",-0.26711,-0.967,0.478,79,0.485,"homocysteine, creatine, glycine, citrulline, creatinine, dimethylglycine, betaine, sarcosine, acetylglycine, ornithine",0.320572103387881,0.314258261397736,FALSE +"HCC95","Input","acyl carnitines",-0.38991,-1.37,0.123,85,0.293,"stearoylcarnitine, propionylcarnitine, palmitoylcarnitine, myristoylcarnitine, malonylcarnitine, heptanoylcarnitine, hexanoylcarnitine",0.910094888560602,0.533132379645891,FALSE +"H3255","Input","alpha amino acids",0.33475,1.2,0.229,115,0.236,"homocysteine, creatine, acetylglycine, sarcosine, glycine, citrulline, dimethylglycine, creatinine, betaine",0.640164517660112,0.627087997029893,FALSE +"H3255","Input","acyl carnitines",-0.35088,-1.24,0.21,179,0.216,"propionylcarnitine, myristoylcarnitine, stearoylcarnitine, palmitoylcarnitine",0.677780705266081,0.665546248849069,FALSE +"H1648","Input","alpha amino acids",0.21893,0.775,0.727,40,0.736,"phosphocreatine, creatine, creatinine, glycine",0.138465589140962,0.133122185662501,FALSE +"H1648","Input","acyl carnitines",0.25529,0.888,0.589,13,1,"palmitoylcarnitine, myristoylcarnitine",0.229884705212898,0,FALSE +"H1975","Input","alpha amino acids",0.30803,1.07,0.36,39,0.361,"homocysteine, creatinine, dimethylglycine, phosphocreatine, ornithine",0.443697499232713,0.442492798094342,FALSE +"H1975","Input","acyl carnitines",-0.41428,-1.45,0.104,125,0.1,"heptanoylcarnitine, hexanoylcarnitine, malonylcarnitine, stearoylcarnitine, myristoylcarnitine, palmitoylcarnitine",0.98296666070122,1,FALSE +"HCC78","Input","alpha amino acids",-0.28078,-1,0.446,103,0.904,"phosphocreatine, citrulline, dimethylglycine, creatinine, homocysteine, betaine, creatine, ornithine, acetylglycine",0.350665141287858,0.0438315695246367,FALSE +"HCC78","Input","acyl carnitines",-0.27409,-0.982,0.474,126,0.469,"hexanoylcarnitine, myristoylcarnitine, palmitoylcarnitine, stearoylcarnitine, heptanoylcarnitine",0.324221658325915,0.328827157284917,FALSE +"H2126","Input","alpha amino acids",-0.28519,-1.01,0.41,104,0.42,"betaine, phosphocreatine, homocysteine, sarcosine, creatine, creatinine, dimethylglycine, citrulline, ornithine",0.387216143280265,0.3767507096021,FALSE +"H2126","Input","acyl carnitines",-0.50072,-1.79,0.0248,178,0.0422,"heptanoylcarnitine, myristoylcarnitine, propionylcarnitine, palmitoylcarnitine, stearoylcarnitine",1.60554831917378,1.37468754903833,TRUE +"HCC827","Input","alpha amino acids",0.26472,0.913,0.539,149,0.546,"ornithine, phosphocreatine, sarcosine, dimethylglycine, creatinine, glycine, creatine, homocysteine, betaine, citrulline",0.268411234813261,0.262807357295263,FALSE +"HCC827","Input","acyl carnitines",-0.15596,-0.563,0.952,34,0.945,"malonylcarnitine, heptanoylcarnitine, propionylcarnitine, hexanoylcarnitine, myristoylcarnitine, stearoylcarnitine, palmitoylcarnitine",0.0213630516155257,0.0245681914907371,FALSE +"CALU3","Input","alpha amino acids",-0.44662,-1.64,0.0501,163,0.0402,"sarcosine, creatine, dimethylglycine, betaine, citrulline, creatinine, glycine, phosphocreatine",1.30016227413275,1.39577394691553,FALSE +"CALU3","Input","acyl carnitines",0.34173,1.15,0.302,62,0.293,"palmitoylcarnitine, myristoylcarnitine, hexanoylcarnitine, stearoylcarnitine",0.519993057042849,0.533132379645891,FALSE +"H2009","Input","alpha amino acids",-0.30219,-1.08,0.359,150,0.724,"betaine, ornithine, creatinine, citrulline, sarcosine, dimethylglycine, homocysteine",0.444905551421681,0.140261433802853,FALSE +"H2009","Input","acyl carnitines",-0.23817,-0.874,0.576,87,0.595,"stearoylcarnitine, palmitoylcarnitine, heptanoylcarnitine, myristoylcarnitine, propionylcarnitine, hexanoylcarnitine",0.239577516576788,0.22548303427145,FALSE +"HCC4006","Input","alpha amino acids",0.24766,0.88,0.589,172,0.607,"sarcosine, glycine, betaine, creatine, acetylglycine, ornithine, phosphocreatine, creatinine, homocysteine, citrulline, dimethylglycine",0.229884705212898,0.216811308924742,FALSE +"HCC4006","Input","acyl carnitines",-0.30744,-1.09,0.344,100,0.351,"stearoylcarnitine, hexanoylcarnitine, propionylcarnitine, malonylcarnitine, palmitoylcarnitine, heptanoylcarnitine",0.46344155742847,0.454692883534176,FALSE +"HCC2279","Input","alpha amino acids",-0.23263,-0.818,0.733,136,0.705,"betaine, creatinine, acetylglycine, glycine, creatine, sarcosine, phosphocreatine",0.134896025358872,0.151810883008601,FALSE +"HCC2279","Input","acyl carnitines",0.55124,1.93,0.00977,75,0.0076,"stearoylcarnitine, palmitoylcarnitine, myristoylcarnitine, propionylcarnitine, malonylcarnitine, hexanoylcarnitine",2.01010543628123,2.11918640771921,TRUE +"H520","Input","alpha amino acids",0.55543,1.95,0.00704,69,0.0214,"homocysteine, phosphocreatine, sarcosine, betaine, creatinine, ornithine, dimethylglycine, creatine, glycine",2.15242734085789,1.66958622665081,TRUE +"H520","Input","acyl carnitines",0.37677,1.34,0.167,115,0.157,"hexanoylcarnitine, malonylcarnitine, myristoylcarnitine, propionylcarnitine, heptanoylcarnitine, palmitoylcarnitine",0.777283528852417,0.804100347590766,FALSE +"HCC15","Input","alpha amino acids",-0.19164,-0.694,0.847,64,0.851,"ornithine, creatinine, dimethylglycine, acetylglycine, sarcosine, betaine, citrulline, glycine, creatine, phosphocreatine",0.0721165896692931,0.0700704399154121,FALSE +"HCC15","Input","acyl carnitines",0.37551,1.31,0.168,112,0.161,"myristoylcarnitine, palmitoylcarnitine, hexanoylcarnitine, stearoylcarnitine, malonylcarnitine, propionylcarnitine",0.774690718274137,0.79317412396815,FALSE +"H460","Input","alpha amino acids",0.33725,1.19,0.246,134,0.257,"homocysteine, phosphocreatine, sarcosine, creatine, dimethylglycine, creatinine, citrulline, ornithine, glycine, betaine",0.609064892896621,0.590066876668705,FALSE +"H460","Input","acyl carnitines",-0.46083,-1.69,0.0309,208,0.0365,"myristoylcarnitine, heptanoylcarnitine, palmitoylcarnitine, stearoylcarnitine",1.51004152057517,1.43770713554353,TRUE +"A549","Input","alpha amino acids",0.14945,0.523,0.97,74,0.975,"ornithine, glycine, citrulline, sarcosine, homocysteine",0.0132282657337552,0.0109953843014632,FALSE +"A549","Input","acyl carnitines",0.42635,1.51,0.0727,39,0.14,"propionylcarnitine, malonylcarnitine, hexanoylcarnitine, stearoylcarnitine",1.13846558914096,0.853871964321762,FALSE +"HCC44","Input","alpha amino acids",0.44653,1.59,0.0656,111,0.0648,"homocysteine, phosphocreatine, creatinine, sarcosine, dimethylglycine, ornithine, creatine, glycine, betaine, citrulline",1.18309616062434,1.18842499412941,FALSE +"HCC44","Input","acyl carnitines",-0.26991,-0.947,0.511,192,0.501,"myristoylcarnitine, stearoylcarnitine, palmitoylcarnitine",0.291579099865287,0.300162274132754,FALSE +"H1703","Input","alpha amino acids",-0.16231,-0.572,0.955,182,0.948,"dimethylglycine, ornithine, betaine, sarcosine",0.0199966284162537,0.0231916626619338,FALSE +"H1703","Input","acyl carnitines",0.32084,1.11,0.335,124,0.321,"propionylcarnitine, hexanoylcarnitine, palmitoylcarnitine, myristoylcarnitine, malonylcarnitine, stearoylcarnitine",0.474955192963155,0.493494967595128,FALSE +"H1299","Input","alpha amino acids",0.29166,1.02,0.401,143,0.417,"homocysteine, sarcosine, citrulline, phosphocreatine, glycine, ornithine, creatinine, dimethylglycine, acetylglycine, betaine",0.396855627379818,0.379863945026242,FALSE +"H1299","Input","acyl carnitines",-0.44634,-1.58,0.053,200,0.0553,"myristoylcarnitine, stearoylcarnitine, palmitoylcarnitine, heptanoylcarnitine",1.27572413039921,1.2572748686953,FALSE diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_venn_diagram.pdf 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Garana (BG) +# Date created: 2023-12-21 +# Last edit: BG 2023-12-21 + +# To recreate: press run through the whole script +# Overview +# 1 - import CCLE data +# 2 - import Coldren et al. data +# 3 - import GSE31625 data +# 4 - import GSE12790 data +# 5 - run panSEA + +rm(list=ls(all=TRUE)) +library(plyr);library(dplyr);library(GSA);library(panSEA);library(GEOquery) + +##### Step 1: Import CCLE data (PRISM drug AUC, drug moa gmt, RNAseq, proteomics, metabolomics) ##### +#### cell line info (CCLE 19Q4) +cell.line.info <- read.csv(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/CCLE_sample_info.csv") +cell.line.info$X <- NULL + +#### drug sensitivity (PRISM AUC) for 481 cancer cell lines +AUC.df <- read.csv(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/PRISM_drug_mean_AUC_6-23-21.csv") +AUC.df$X <- NULL + +#### drug sets (PRISM moa) +gmt <- GSA.read.gmt(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/MOA_gmt_file_n6_no_special_chars.gmt") + +#### RNAseq (CCLE 19Q4) for 327 adherent cancer cell lines +download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin", + destfile = paste0(getwd(),"/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin")) +load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin") +download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin", + destfile = paste0(getwd(),"/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin")) +load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin") +RNA.df <- rbind(RNA.first200, RNA.rest) + +#### transcriptomics (IMPROVE) +options(timeout = 360) +download.file("https://figshare.com/ndownloader/files/42131304", "transcriptomics.csv.gz") +transcr.df <- read.csv(gzfile("transcriptomics.csv.gz"),fileEncoding="UTF-16LE") + +# merge with genes, samples to stop using improve IDs +transcr.df <- merge(transcr.df, genes) +transcr.df <- merge(transcr.df, samples) + +#### proteomics (IMPROVE) +download.file("https://figshare.com/ndownloader/files/41466702", "proteomics.csv.gz") +prot.df <- read.csv(gzfile("proteomics.csv.gz"),fileEncoding="UTF-16LE") + +allgenes = readr::read_csv("https://figshare.com/ndownloader/files/40576109") +genes = allgenes|> + dplyr::select(gene_symbol,entrez_id)|> + dplyr::distinct() + +allsamples = readr::read_csv('https://figshare.com/ndownloader/files/40576103') +samples = allsamples|> + dplyr::select(other_id,improve_sample_id)|> + unique() + +# merge prot.df with genes, samples to stop using improve IDs +prot.df <- merge(prot.df, genes) + +#### metabolomics (CCLE) +met.df <- read.csv(paste0("~/OneDrive - PNNL/Documents/GitHub/panSEA/Examples/", + "Inputs/CCLE_metabolomics_20190502.csv")) + +Sys.setenv("VROOM_CONNECTION_SIZE"=300000) # increase connection buffer size +##### Step 2: Coldren et al (EGFR inhibitor ) ##### +### Identify sensitive (SENS) or resistant (RES) cells +### based on Coldren et al, 2006 paper +### not in CCLE RNAseq: CALU3 +SENS.cells <- c("NCIH358","NCIH322C","CALU3","NCIH1334","NCIH1648", + "HCC827","HCC78","NCIH2126","HCC193","HCC95", + "NCIH3255","HCC4006","NCIH2009","NCIH1650","NCIH820","NCIH1975") +RES.cells <- c("NCIH125","NCIH1703","A549","NCIH157","NCIH460","NCIH520", + "HCC44","HCC15","NCIH157","NCIH1299","HCC2279") +SENS.cell.info <- cell.line.info[cell.line.info$stripped_cell_line_name %in% SENS.cells,] # 5 cell lines: NCIH1650, HCC95, NCIH1975, NCIH1648, NCIH2126 +SENS.CCLE_ID <- SENS.cell.info$CCLE_ID +RES.cell.info <- cell.line.info[cell.line.info$stripped_cell_line_name %in% RES.cells,] # 7 cell lines: NCIH520, NCIH460, NCIH1299, HCC44, A549, NCIH1703, HCC15 +RES.CCLE_ID <- RES.cell.info$CCLE_ID +Coldren.samples <- list(2:6, 7:13) + +### Get data for SENS and RES cells +## transcriptomics +SENS.data <- merge(SENS.cell.info, transcr.df, by="CCLE_ID") +SENS.data$stripped_cell_line_name <- NULL +rownames(SENS.data) <- SENS.data$CCLE_ID +SENS.data$CCLE_ID <- NULL +RES.data <- merge(RES.cell.info, transcr.df, by="CCLE_ID") +RES.data$stripped_cell_line_name <- NULL +rownames(RES.data) <- RES.data$CCLE_ID +RES.data$CCLE_ID <- NULL +data.SENS <- t(SENS.data) +data.RES <- t(RES.data) +Coldren.full.transcr.data <- cbind(data.SENS,data.RES) + +## proteomics +SENS.data <- merge(SENS.cell.info, prot.df, by="CCLE_ID") +SENS.data$stripped_cell_line_name <- NULL +rownames(SENS.data) <- SENS.data$CCLE_ID +SENS.data$CCLE_ID <- NULL +RES.data <- merge(RES.cell.info, prot.df, by="CCLE_ID") +RES.data$stripped_cell_line_name <- NULL +rownames(RES.data) <- RES.data$CCLE_ID +RES.data$CCLE_ID <- NULL +data.SENS <- t(SENS.data) +data.RES <- t(RES.data) +Coldren.full.prot.data <- cbind(data.SENS,data.RES) + +## metabolomics +SENS.data <- merge(SENS.cell.info, met.df, by="CCLE_ID") +SENS.data$stripped_cell_line_name <- NULL +rownames(SENS.data) <- SENS.data$CCLE_ID +SENS.data$CCLE_ID <- NULL +RES.data <- merge(RES.cell.info, met.df, by="CCLE_ID") +RES.data$stripped_cell_line_name <- NULL +rownames(RES.data) <- RES.data$CCLE_ID +RES.data$CCLE_ID <- NULL +data.SENS <- t(SENS.data) +data.RES <- t(RES.data) +Coldren.full.met.data <- cbind(data.SENS,data.RES) + +#### Get smaller data sets for comparison to GSE31625 +### randomly sample 3 sensitive cell lines & 2 resistant cell lines +sampled.SENS.CCLE_ID <- sample(SENS.CCLE_ID, 3) + +sampled.RES.CCLE_ID <- sample(RES.CCLE_ID, 2) + +### Get data for SENS and RES cells +## transcriptomics +SENS.data <- merge(SENS.cell.info[SENS.cell.info$CCLE_ID %in% + sampled.SENS.CCLE_ID, ], transcr.df, + by = "CCLE_ID") +SENS.data$stripped_cell_line_name <- NULL +rownames(SENS.data) <- SENS.data$CCLE_ID +SENS.data$CCLE_ID <- NULL +RES.data <- merge(RES.cell.info[RES.cell.info$CCLE_ID %in% + sampled.RES.CCLE_ID, ], transcr.df, + by = "CCLE_ID") +RES.data$stripped_cell_line_name <- NULL +rownames(RES.data) <- RES.data$CCLE_ID +RES.data$CCLE_ID <- NULL +data.SENS <- t(SENS.data) +data.RES <- t(RES.data) +Coldren.transcr.data <- cbind(data.SENS,data.RES) + +## proteomics +SENS.data <- merge(SENS.cell.info[SENS.cell.info$CCLE_ID %in% + sampled.SENS.CCLE_ID, ], prot.df, + by = "CCLE_ID") +SENS.data$stripped_cell_line_name <- NULL +rownames(SENS.data) <- SENS.data$CCLE_ID +SENS.data$CCLE_ID <- NULL +RES.data <- merge(RES.cell.info[RES.cell.info$CCLE_ID %in% + sampled.RES.CCLE_ID, ], prot.df, + by = "CCLE_ID") +RES.data$stripped_cell_line_name <- NULL +rownames(RES.data) <- RES.data$CCLE_ID +RES.data$CCLE_ID <- NULL +data.SENS <- t(SENS.data) +data.RES <- t(RES.data) +Coldren.prot.data <- cbind(data.SENS,data.RES) + +## metabolomics +SENS.data <- merge(SENS.cell.info[SENS.cell.info$CCLE_ID %in% + sampled.SENS.CCLE_ID, ], met.df, + by = "CCLE_ID") +SENS.data$stripped_cell_line_name <- NULL +rownames(SENS.data) <- SENS.data$CCLE_ID +SENS.data$CCLE_ID <- NULL +RES.data <- merge(RES.cell.info[RES.cell.info$CCLE_ID %in% + sampled.RES.CCLE_ID, ], met.df, + by = "CCLE_ID") +RES.data$stripped_cell_line_name <- NULL +rownames(RES.data) <- RES.data$CCLE_ID +RES.data$CCLE_ID <- NULL +data.SENS <- t(SENS.data) +data.RES <- t(RES.data) +Coldren.met.data <- cbind(data.SENS,data.RES) + +##### Step 3: GSE31625 (EGFR inhibitor) ##### +# load series and platform data from GEO +gset <- getGEO("GSE31625", GSEMatrix =TRUE, AnnotGPL=TRUE) +if (length(gset) > 1) idx <- grep("GPL570", attr(gset, "names")) else idx <- 1 +gset <- gset[[idx]] + +# make proper column names to match toptable +fvarLabels(gset) <- make.names(fvarLabels(gset)) + +# group membership for all samples +gsms <- paste0("X11111111XXXXXXXXX0000000XXXXXXXX0000X0000001111") # 0 is phenotype of numerator in FC; 1 of denominator; X: excluded +sml <- strsplit(gsms, split="")[[1]] + +# filter out excluded samples (marked as "X") +sel <- which(sml != "X") +sml <- sml[sel] + +##### Step 4: GSE12790 (EGFR inhibitor) ##### +# load series and platform data from GEO +gset <- getGEO("GSE12790", GSEMatrix =TRUE, AnnotGPL=TRUE) +if (length(gset) > 1) idx <- grep("GPL570", attr(gset, "names")) else idx <- 1 +gset <- gset[[idx]] + +# make proper column names to match toptable +fvarLabels(gset) <- make.names(fvarLabels(gset)) + +# group membership for all samples +gsms <- paste0("XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX1XX", + "X0X11X1XX1X1X1XX1XX1X1110X1XX1XXX11X1XX0XX1XXXXX") # 0 is phenotype of numerator in FC; 1 of denominator; X: excluded +sml <- strsplit(gsms, split="")[[1]] + +# filter out excluded samples (marked as "X") +sel <- which(sml != "X") +sml <- sml[sel] + +#### Get smaller data sets for comparison to GSE31625 +### randomly sample 3 sensitive cell lines & 2 resistant cell lines + +##### Step 5: run panSEA ##### +# IMPORTANT: each group must have the same # & position of samples across data sets +# e.g. "Sensitive" samples must be in the same columns across input data.list +# but "Resistant" could have different # as "Sensitive" hypothetically +group.names = c("Sensitive", "Resistant") +#### Step 5a: Fig2: 3 transcriptomic signatures of EGFRi sensitivity #### +types <- c("GSE12790", "GSE31625", "Coldren et al") +data.list <- list() +group.samples <- list() + +Fig2.panSEA <- panSEA::panSEA(data.list, types, group.names = group.names, + group.samples = group.samples) + +#### Step 5b: Fig3: transcriptomics, proteomics, and metabolomics signatures #### +types <- c("transcriptomics", "proteomics", "metabolomics") +data.list <- list() +feature.names <- c("Gene", "Gene", "Metabolite") +group.samples <- list() +gmt.features <- list("msigdb_Homo sapiens_C2_CP:KEGG", + "msigdb_Homo sapiens_C2_CP:KEGG", + "hmdb") + +Fig3.panSEA <- panSEA::panSEA(data.list, types, feature.names, + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features) + +#### Step 5c: Fig4: Fig3 but only querying non-small cell lung cancer cell line data #### +lung.samples <- cell.line.info[cell.line.info$tissue == "lung", ] # check column, lung filter +lung.RNAseq <- RNAseq[RNAseq$CCLE_ID %in% lung.samples, ] +expression <- list(lung.RNAseq, lung.RNAseq, lung.RNAseq) + +Fig3.panSEA <- panSEA::panSEA(data.list, types, feature.names, + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression) diff --git a/Examples/panSEA_examples_1group.R b/Examples/panSEA_examples_1group.R new file mode 100644 index 0000000..a5fa71d --- /dev/null +++ b/Examples/panSEA_examples_1group.R @@ -0,0 +1,569 @@ +# panSEA examples +# Author: Belinda B. Garana (BG) +# Date created: 2023-12-21 +# Last edit: BG 2023-12-21 + +# To recreate: press run through the whole script +# Overview +# 1 - import CCLE data +# 2 - import Coldren et al. data & run differential expression analysis +# 3 - import GSE31625 data & run differential expression analysis +# 4 - import GSE12790 data & run differential expression analysis +# 5 - run panSEA + +rm(list=ls(all=TRUE)) +library(plyr);library(dplyr);library(GSA);library(panSEA);library(GEOquery) +base.path <- "~/OneDrive - PNNL/Documents/GitHub/panSEA/Examples/" +setwd(paste0(base.path, "Inputs")) + +# function to save results +savePanSEA <- function(panSEA.results, fig.folder) { + # set file names + DMEA.files <- list("DMEA_results.csv" = + panSEA.results$mDMEA.results[[1]]$compiled.results$results, + "DMEA_mean_results.csv" = + panSEA.results$mDMEA.results[[1]]$compiled.results$mean.results, + "DMEA_correlation_matrix.pdf" = + panSEA.results$mDMEA.results[[1]]$compiled.results$corr.matrix, + "DMEA_venn_diagram.pdf" = + panSEA.results$mDMEA.results[[1]]$compiled.results$venn.diagram, + "DMEA_dot_plot.pdf" = + panSEA.results$mDMEA.results[[1]]$compiled.results$dot.plot, + "DMEA_interactive_network.graph.html" = + panSEA.results$mDMEA.network[[1]]$interactive) + GSEA.files <- list("GSEA_results.csv" = + panSEA.results$mGSEA.results[[1]]$compiled.results$results, + "GSEA_mean_results.csv" = + panSEA.results$mGSEA.results[[1]]$compiled.results$mean.results, + "GSEA_correlation_matrix.pdf" = + panSEA.results$mGSEA.results[[1]]$compiled.results$corr.matrix, + "GSEA_venn_diagram.pdf" = + panSEA.results$mGSEA.results[[1]]$compiled.results$venn.diagram, + "GSEA_dot_plot.pdf" = + panSEA.results$mGSEA.results[[1]]$compiled.results$dot.plot, + "GSEA_interactive_network.graph.html" = + panSEA.results$mGSEA.network[[1]]$interactive) + all.files <- list('GSEA' = GSEA.files, + 'DMEA' = DMEA.files) + + base.path <- getwd() + dir.create(fig.folder) + setwd(fig.folder) + for (i in 1:length(all.files)) { + # create local folder for subset of results + setwd(paste0(base.path, "/", fig.folder)) + dir.create(names(all.files)[i]) + setwd(names(all.files)[i]) + + # save results locally + temp.files <- all.files[[i]] + + CSV.files <- names(temp.files)[grepl(".csv", names(temp.files))] + for (j in 1:length(CSV.files)) { + write.csv(temp.files[[CSV.files[j]]], CSV.files[j], row.names = FALSE) + } + + PDF.files <- names(temp.files)[grepl(".pdf", names(temp.files))] + for (j in 1:length(PDF.files)) { + ggplot2::ggsave(PDF.files[j], temp.files[[PDF.files[j]]], device = "pdf") + } + + HTML.files <- names(temp.files)[grepl(".html", names(temp.files))] + if (length(HTML.files) > 0) { + for (j in 1:length(HTML.files)) { + visNetwork::visSave(temp.files[[HTML.files[j]]], HTML.files[j]) + } + } + } + setwd(paste0(base.path, "/", fig.folder)) + saveRDS(panSEA.results, paste0("panSEA_", fig.folder, ".rds")) +} + +##### Step 1: Import CCLE data (PRISM drug AUC, drug moa gmt, RNAseq, proteomics, metabolomics) ##### +#### cell line info (CCLE 19Q4) +cell.line.info <- read.csv(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/CCLE_sample_info.csv") +cell.line.info$X <- NULL + +#### RNAseq (CCLE 19Q4) for 327 adherent cancer cell lines +download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin", + destfile = paste0(getwd(),"/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin")) +load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin") +download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin", + destfile = paste0(getwd(),"/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin")) +load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin") +RNA.df <- rbind(RNA.first200, RNA.rest) +RNA.first200 <- NULL +RNA.rest <- NULL + +#### proteomics (CCLE from IMPROVE) +#download.file("https://figshare.com/ndownloader/files/41466702", "proteomics.csv.gz") +prot.df <- read.csv(gzfile("proteomics.csv.gz"),fileEncoding="UTF-16LE") + +allgenes = readr::read_csv("https://figshare.com/ndownloader/files/40576109") +genes = allgenes|> + dplyr::select(gene_symbol,entrez_id)|> + dplyr::distinct() +genes <- genes[genes$gene_symbol %in% colnames(RNA.df)[2:ncol(RNA.df)], ] + +allsamples = readr::read_csv('https://figshare.com/ndownloader/files/40576103') +CCLE.samples <- dplyr::distinct(allsamples[allsamples$id_source == "CCLE", + c("other_id","improve_sample_id")]) + +# merge prot.df with genes, samples to stop using improve IDs +prot.df <- merge(prot.df, CCLE.samples) +prot.df <- merge(prot.df, genes) +prot.df$entrez_id <- NULL +prot.df <- dplyr::distinct(prot.df) + +# convert to wide format for DMEA +prot.df <- reshape2::dcast(prot.df, other_id ~ gene_symbol, mean, + value.var = "proteomics") +colnames(prot.df)[1] <- "CCLE_ID" + +#### metabolomics (CCLE) +met.df <- read.csv(paste0("~/OneDrive - PNNL/Documents/GitHub/panSEA/Examples/", + "Inputs/CCLE_metabolomics_20190502.csv")) +met.df$DepMap_ID <- NULL + +Sys.setenv("VROOM_CONNECTION_SIZE"=300000) # increase connection buffer size +setwd(base.path) +##### Step 2: Coldren et al (EGFR inhibitor ) ##### +### Identify sensitive (SENS) or resistant (RES) cells +### based on Coldren et al, 2006 paper +SENS.cells <- c("NCIH358","NCIH322C","CALU3","NCIH1334","NCIH1648", + "HCC827","HCC78","NCIH2126","HCC193","HCC95", + "NCIH3255","HCC4006","NCIH2009","NCIH1650","NCIH820","NCIH1975") +RES.cells <- c("NCIH125","NCIH1703","A549","NCIH157","NCIH460","NCIH520", + "HCC44","HCC15","NCIH157","NCIH1299","HCC2279") +SENS.cell.info <- cell.line.info[cell.line.info$stripped_cell_line_name %in% SENS.cells,] +SENS.stripped_cell_line_name <- SENS.cell.info$stripped_cell_line_name +# 12 SENS cell lines: "HCC827", "NCIH1650", "HCC4006", "NCIH3255", "CALU3", +# "HCC95", "HCC78", "NCIH1975", "NCIH1648", "NCIH2126", "NCIH358", "NCIH2009" + +RES.cell.info <- cell.line.info[cell.line.info$stripped_cell_line_name %in% RES.cells,] +RES.stripped_cell_line_name <- RES.cell.info$stripped_cell_line_name +# 8 RES cell lines: "NCIH520", "NCIH460", "NCIH1299", "HCC44", "A549", +# "HCC2279", "NCIH1703", "HCC15" + +# Coldren.samples <- list(seq(2, length.out = length(SENS.stripped_cell_line_name)), +# seq((length(SENS.stripped_cell_line_name) + 2), +# length.out = length(RES.stripped_cell_line_name))) + +Coldren.sample.IDs <- CCLE.samples[CCLE.samples$other_id %in% + c(SENS.cell.info$CCLE_Name, + RES.cell.info$CCLE_Name),] +colnames(Coldren.sample.IDs)[1] <- "CCLE_Name" # change other_id to CCLE_Name +Coldren.sample.IDs <- merge(Coldren.sample.IDs, cell.line.info) +# Coldren.SENS.IDs <- Coldren.sample.IDs[Coldren.sample.IDs$CCLE_Name %in% +# SENS.cell.info$CCLE_Name, +# c("improve_sample_id", "CCLE_ID")] +# Coldren.RES.IDs <- Coldren.sample.IDs[Coldren.sample.IDs$CCLE_Name %in% +# RES.cell.info$CCLE_Name, +# c("improve_sample_id", "CCLE_ID")] + +### Get data for SENS and RES cells +## transcriptomics +SENS.data <- RNA.df[RNA.df$CCLE_ID %in% SENS.cell.info$CCLE_Name, ] +# 5 SENS cell lines: "NCIH1650_LUNG", "HCC95_LUNG", "NCIH1975_LUNG", +# "NCIH1648_LUNG", "NCIH2126_LUNG" +rownames(SENS.data) <- SENS.data$CCLE_ID +SENS.data$CCLE_ID <- NULL + +RES.data <- RNA.df[RNA.df$CCLE_ID %in% RES.cell.info$CCLE_Name, ] +# 7 cell lines: "NCIH520_LUNG", "NCIH460_LUNG", "NCIH1299_LUNG", "HCC44_LUNG", +# "A549_LUNG", "NCIH1703_LUNG", "HCC15_LUNG" +rownames(RES.data) <- RES.data$CCLE_ID +RES.data$CCLE_ID <- NULL + +data.SENS <- t(SENS.data) +data.RES <- t(RES.data) +Coldren.transcr <- as.data.frame(cbind(data.SENS,data.RES)) +Coldren.transcr$Gene <- rownames(Coldren.transcr) +Coldren.transcr <- Coldren.transcr[ , c("Gene", + colnames(Coldren.transcr)[ + 1:(ncol(Coldren.transcr)-1)])] + +## proteomics +SENS.data <- prot.df[prot.df$CCLE_ID %in% SENS.cell.info$CCLE_Name, ] +rownames(SENS.data) <- SENS.data$CCLE_ID +SENS.data$CCLE_ID <- NULL +# 8 cell lines: "HCC827_LUNG", "HCC95_LUNG", "NCIH1650_LUNG", "NCIH1975_LUNG", +# "NCIH2009_LUNG", "NCIH2126_LUNG", "NCIH3255_LUNG", "NCIH358_LUNG" + +RES.data <- prot.df[prot.df$CCLE_ID %in% RES.cell.info$CCLE_Name, ] +rownames(RES.data) <- RES.data$CCLE_ID +RES.data$CCLE_ID <- NULL +# 7 cell lines: "A549_LUNG", "HCC15_LUNG", "HCC44_LUNG", "NCIH1299_LUNG", +# "NCIH1703_LUNG", "NCIH460_LUNG", "NCIH520_LUNG" + +data.SENS <- t(SENS.data) +data.RES <- t(RES.data) +Coldren.prot <- as.data.frame(cbind(data.SENS,data.RES)) +Coldren.prot$Gene <- rownames(Coldren.prot) +Coldren.prot <- Coldren.prot[ , c("Gene", + colnames(Coldren.prot)[ + 1:(ncol(Coldren.prot)-1)])] + +## metabolomics +SENS.data <- met.df[met.df$CCLE_ID %in% SENS.cell.info$CCLE_Name, ] +rownames(SENS.data) <- SENS.data$CCLE_ID +SENS.data$CCLE_ID <- NULL +# 12 cell lines: "NCIH358_LUNG", "NCIH1650_LUNG", "HCC95_LUNG", +# "NCIH3255_LUNG", "NCIH1648_LUNG", "NCIH1975_LUNG", "HCC78_LUNG", +# "NCIH2126_LUNG", "HCC827_LUNG", "CALU3_LUNG", "NCIH2009_LUNG", "HCC4006_LUNG" + +RES.data <- met.df[met.df$CCLE_ID %in% RES.cell.info$CCLE_Name, ] +rownames(RES.data) <- RES.data$CCLE_ID +RES.data$CCLE_ID <- NULL +# 8 cell lines: "HCC2279_LUNG", "NCIH520_LUNG", "HCC15_LUNG", "NCIH460_LUNG", +# "A549_LUNG", "HCC44_LUNG", "NCIH1703_LUNG", "NCIH1299_LUNG" + +data.SENS <- t(SENS.data) +data.RES <- t(RES.data) +Coldren.met <- as.data.frame(cbind(data.SENS,data.RES)) +Coldren.met$Metabolite <- rownames(Coldren.met) +Coldren.met <- Coldren.met[ , c("Metabolite", + colnames(Coldren.met)[ + 1:(ncol(Coldren.met)-1)])] + +### run differential expression analysis +### have to do this separately for each omics because they have different +### numbers of SENS and RES samples +## transcriptomics +# group.samples <- list(seq(2, length.out = nrow(RNA.df[ +# RNA.df$CCLE_ID %in% SENS.cell.info$CCLE_Name, ])), +# seq((nrow(RNA.df[RNA.df$CCLE_ID %in% +# SENS.cell.info$CCLE_Name, ]) + 2), +# length.out = nrow(met.df[met.df$CCLE_ID %in% RES.cell.info$CCLE_Name, ]))) +group.samples <- list(RNA.df$CCLE_ID[RNA.df$CCLE_ID %in% + SENS.cell.info$CCLE_Name], + RNA.df$CCLE_ID[RNA.df$CCLE_ID %in% + RES.cell.info$CCLE_Name]) +Coldren.transcr.DEGs <- panSEA::mDEG(list(Coldren.transcr), types = "Transcriptomics", + group.names = c("Sensitive", "Resistant"), + group.samples, "Gene")$all.results[[1]] +write.csv(Coldren.transcr.DEGs, "Coldren_transcriptomics_DEGs_before_avg.csv", + row.names = FALSE) +Coldren.transcr.DEGs <- read.csv("Coldren_transcriptomics_DEGs_before_avg.csv") +library(plyr);library(dplyr) +Coldren.transcr <- ddply(Coldren.transcr.DEGs, .(Gene), summarise, + Log2FC = mean(Log2FC, na.rm=TRUE)) #prevent duplicate gene names +write.csv(Coldren.transcr, "Coldren_transcriptomics_DEGs.csv", + row.names = FALSE) +Coldren.transcr <- read.csv("Coldren_transcriptomics_DEGs.csv") + +## proteomics +group.samples <- list(prot.df$CCLE_ID[prot.df$CCLE_ID %in% + SENS.cell.info$CCLE_Name], + prot.df$CCLE_ID[prot.df$CCLE_ID %in% + RES.cell.info$CCLE_Name]) +Coldren.prot.DEGs <- panSEA::mDEG(list(Coldren.prot), types = "Proteomics", + group.names = c("Sensitive", "Resistant"), + group.samples, "Gene")$all.results[[1]] +write.csv(Coldren.prot.DEGs, "Coldren_proteomics_DEGs_before_avg.csv", + row.names = FALSE) +Coldren.prot.DEGs <- read.csv("Coldren_proteomics_DEGs_before_avg.csv") +Coldren.prot <- plyr::ddply(Coldren.prot.DEGs, .(Gene), summarise, + Log2FC = mean(Log2FC, na.rm=TRUE)) #prevent duplicate gene names +write.csv(Coldren.prot, "Coldren_proteomics_DEGs.csv", + row.names = FALSE) +Coldren.prot <- read.csv("Coldren_proteomics_DEGs.csv") + +## metabolomics +group.samples <- list(met.df$CCLE_ID[met.df$CCLE_ID %in% + SENS.cell.info$CCLE_Name], + met.df$CCLE_ID[met.df$CCLE_ID %in% + RES.cell.info$CCLE_Name]) +Coldren.met.DEGs <- panSEA::mDEG(list(Coldren.met), types = "Metabolomics", + group.names = c("Sensitive", "Resistant"), + group.samples, "Metabolite")$all.results[[1]] +write.csv(Coldren.met.DEGs, "Coldren_metabolomics_DEGs_before_avg.csv", + row.names = FALSE) +Coldren.met.DEGs <- read.csv("Coldren_metabolomics_DEGs_before_avg.csv") +Coldren.met <- plyr::ddply(Coldren.met.DEGs, .(Metabolite), summarise, + Log2FC = mean(Log2FC, na.rm=TRUE)) #prevent duplicate gene names +write.csv(Coldren.met, "Coldren_metabolomics_DEGs.csv", + row.names = FALSE) +Coldren.met <- read.csv("Coldren_metabolomics_DEGs.csv") + +##### Step 3: GSE31625 (EGFR inhibitor) ##### +# load series and platform data from GEO +gset <- getGEO("GSE31625", GSEMatrix =TRUE, AnnotGPL=TRUE) +if (length(gset) > 1) idx <- grep("GPL570", attr(gset, "names")) else idx <- 1 +gset <- gset[[idx]] + +# make proper column names to match toptable +fvarLabels(gset) <- make.names(fvarLabels(gset)) + +# group membership for all samples +gsms <- paste0("X11111111XXXXXXXXX0000000XXXXXXXX0000X0000001111") # 0 is phenotype of numerator in FC; 1 of denominator; X: excluded +sml <- strsplit(gsms, split="")[[1]] + +# filter out excluded samples (marked as "X") +sel <- which(sml != "X") +sml <- sml[sel] +gset <- gset[ ,sel] + +### run differential expression analysis +# log2 transformation +ex <- exprs(gset) +qx <- as.numeric(quantile(ex, c(0., 0.25, 0.5, 0.75, 0.99, 1.0), na.rm=T)) +LogC <- (qx[5] > 100) || + (qx[6]-qx[1] > 50 && qx[2] > 0) +if (LogC) { ex[which(ex <= 0)] <- NaN +exprs(gset) <- log2(ex) } +SENS.expr <- as.data.frame(exprs(gset[,which(sml==0)])) +RES.expr <- as.data.frame(exprs(gset[,which(sml==1)])) + +# assign samples to groups and set up design matrix +gs <- factor(sml) +groups <- make.names(c("test","test2")) +levels(gs) <- groups +gset$group <- gs +design <- model.matrix(~group + 0, gset) +colnames(design) <- levels(gs) + +fit <- limma::lmFit(gset, design) # fit linear model + +# set up contrasts of interest and recalculate model coefficients +cts <- paste(groups[1], groups[2], sep="-") +cont.matrix <- limma::makeContrasts(contrasts=cts, levels=design) +fit2 <- limma::contrasts.fit(fit, cont.matrix) + +# compute statistics and table of top significant genes +fit2 <- limma::eBayes(fit2, 0.01) +tT <- limma::topTable(fit2, adjust="fdr", sort.by="B", number=nrow(fit2)) +tT <- subset(tT, select=c("ID","adj.P.Val","P.Value","t","B","logFC","Gene.symbol","Gene.title")) # 22,215 genes +tT.noblanks <- tT[tT$Gene.symbol!="",] # 21,146 genes +colnames(tT.noblanks)[6] <- "Log2FC" +colnames(tT.noblanks)[7] <- "Gene" +GSE31625.DEGs <- tT.noblanks +GSE31625.DEGs$Log2Transformed <- LogC +write.csv(GSE31625.DEGs, "GSE31625_transcriptomics_DEGs_before_avg.csv", + row.names = FALSE) +GSE31625.DEGs <- read.csv("GSE31625_transcriptomics_DEGs_before_avg.csv") +GSE31625 <- plyr::ddply(GSE31625.DEGs, .(Gene), summarise, + Log2FC = mean(Log2FC, na.rm=TRUE)) #prevent duplicate gene names +write.csv(GSE31625, "GSE31625_transcriptomics_DEGs.csv", + row.names = FALSE) +GSE31625 <- read.csv("GSE31625_transcriptomics_DEGs.csv") + +# GSE31625.DEGs <- panSEA::mDEG(GSE31625, types = "Transcriptomics", +# group.names = c("Sensitive", "Resistant"), +# list(sml[which(sml == 0)], sml[which(sml == 1)]) +# )$all.results + +##### Step 4: GSE12790 (EGFR inhibitor) ##### +# load series and platform data from GEO +gset <- getGEO("GSE12790", GSEMatrix =TRUE, AnnotGPL=TRUE) +if (length(gset) > 1) idx <- grep("GPL570", attr(gset, "names")) else idx <- 1 +gset <- gset[[idx]] + +# make proper column names to match toptable +fvarLabels(gset) <- make.names(fvarLabels(gset)) + +# group membership for all samples +gsms <- paste0("XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX1XX", + "X0X11X1XX1X1X1XX1XX1X1110X1XX1XXX11X1XX0XX1XXXXX") # 0 is phenotype of numerator in FC; 1 of denominator; X: excluded +sml <- strsplit(gsms, split="")[[1]] + +# filter out excluded samples (marked as "X") +sel <- which(sml != "X") +sml <- sml[sel] +gset <- gset[ ,sel] + +### run differential expression analysis +# log2 transformation +ex <- exprs(gset) +qx <- as.numeric(quantile(ex, c(0., 0.25, 0.5, 0.75, 0.99, 1.0), na.rm=T)) +LogC <- (qx[5] > 100) || + (qx[6]-qx[1] > 50 && qx[2] > 0) +if (LogC) { ex[which(ex <= 0)] <- NaN +exprs(gset) <- log2(ex) } + +# assign samples to groups and set up design matrix +gs <- factor(sml) +groups <- make.names(c("test","test2")) +levels(gs) <- groups +gset$group <- gs +design <- model.matrix(~group + 0, gset) +colnames(design) <- levels(gs) + +fit <- limma::lmFit(gset, design) # fit linear model + +# set up contrasts of interest and recalculate model coefficients +cts <- paste(groups[1], groups[2], sep="-") +cont.matrix <- limma::makeContrasts(contrasts=cts, levels=design) +fit2 <- limma::contrasts.fit(fit, cont.matrix) + +# compute statistics and table of top significant genes +fit2 <- limma::eBayes(fit2, 0.01) +tT <- limma::topTable(fit2, adjust="fdr", sort.by="B", number=nrow(fit2)) + +tT <- subset(tT, select=c("ID","adj.P.Val","P.Value","t","B","logFC","Gene.symbol","Gene.title")) # 54,675 genes +tT.noblanks <- tT[tT$Gene.symbol!="",] #45,118 genes +colnames(tT.noblanks)[6] <- "Log2FC" +colnames(tT.noblanks)[7] <- "Gene" +GSE12790.DEGs <- tT.noblanks +GSE12790.DEGs$Log2Transformed <- LogC +write.csv(GSE12790.DEGs, "GSE12790_transcriptomics_DEGs_before_avg.csv", + row.names = FALSE) +GSE12790.DEGs <- read.csv("GSE12790_transcriptomics_DEGs_before_avg.csv") +GSE12790 <- dplyr::distinct(plyr::ddply(GSE12790.DEGs, .(Gene), summarise, + Log2FC = mean(Log2FC, na.rm=TRUE))) #prevent duplicate gene names +write.csv(GSE12790, "GSE12790_transcriptomics_DEGs.csv", + row.names = FALSE) +GSE12790 <- read.csv("GSE12790_transcriptomics_DEGs.csv") + +# GSE12790.DEGs <- panSEA::mDEG(GSE12790, types = "Transcriptomics", +# group.names = c("Sensitive", "Resistant"), +# list(sml[which(sml == 0)], sml[which(sml == 1)]) +# )$all.results + +##### Step 5: run panSEA ##### +# IMPORTANT: each group must have the same # & position of samples across data sets +# e.g. "Sensitive" samples must be in the same columns across input data.list +# but "Resistant" could have different # as "Sensitive" hypothetically +group.names <- "Sensitive vs. Resistant" +group.samples <- 2 + +# get gene set info +msigdb.info <- msigdbr::msigdbr("Homo sapiens", "C2", "CP:KEGG") + +# extract necessary info into data frame +msigdb.info <- as.data.frame(msigdb.info[, c( + "gene_symbol", + "gs_name", + "gs_description" +)]) + +gene.gmt <- DMEA::as_gmt( + msigdb.info, "gene_symbol", "gs_name", min.per.set = 6, + descriptions = "gs_description") +saveRDS(gene.gmt, "gmt_MSigDB_Homo-sapiens_C2_CP:KEGG.rds") +gene.gmt <- readRDS("Inputs/gmt_MSigDB_Homo-sapiens_C2_CP:KEGG.rds") + +# get metabolite set info +# based on hmdb v5.0 downloaded 20231220: https://hmdb.ca/downloads +hmdb <- XML::xmlToDataFrame("hmdb_metabolites.xml") +saveRDS(hmdb, "hmdb_metabolites_dataframe.rds") +hmdb <- readRDS("hmdb_metabolites_dataframe.rds") +#hmdb$class <- sub(".*belongs to the class of organic compounds known as (.+)\\..*", "\\1", hmdb$taxonomy) +hmdb$class <- NA +hmdb$class <- stringr::str_match(hmdb$taxonomy, "belongs to the class of organic compounds known as\\s*(.*?)\\s*\\. ")[ , 2] +#inorganic.hmdb <- hmdb[is.na(hmdb$class), ] # 72291 / 217920 +hmdb[is.na(hmdb$class), ]$class <- + stringr::str_match( + hmdb[is.na(hmdb$class), ]$taxonomy, + "belongs to the class of inorganic compounds known as\\s*(.*?)\\s*\\. ")[ , 2] +#unclassified.hmdb <- hmdb[is.na(hmdb$class), ] # 71984 / 217920 +#nonblank.unclassified.hmdb <- unclassified.hmdb[unclassified.hmdb$taxonomy != "\n ", ] # 1 / 71984 +hmdb[is.na(hmdb$class), ]$class <- + stringr::str_match( + hmdb[is.na(hmdb$class), ]$taxonomy, + "belongs to the class of chemical entities known as\\s*(.*?)\\s*\\. ")[ , 2] +#unclassified.hmdb <- hmdb[is.na(hmdb$class), ] # 71983 / 217920 +saveRDS(hmdb, "hmdb_metabolites_dataframe_with_class.rds") +hmdb <- readRDS("hmdb_metabolites_dataframe_with_class.rds") +hmdb <- dplyr::distinct(na.omit(hmdb[ , c("name", "class")])) # 145937 metabolites + +met.gmt <- DMEA::as_gmt(hmdb, "name", "class", min.per.set = 6) +saveRDS(met.gmt, "gmt_HMDB.rds") + +hmdb <- readRDS("hmdb_metabolites_dataframe_with_class.rds") +hmdb <- dplyr::distinct(na.omit(hmdb[ , c("name", "class")])) # 145937 metabolites +# hmdb.wide <- reshape2::dcast(hmdb, class ~ name) +# hmdb.match <- colnames(hmdb.wide)[tolower(colnames(hmdb.wide)) %in% colnames(met.df)[2:ncol(met.df)]] # 46 / 225 +hmdb.CCLE <- hmdb[tolower(hmdb$name) %in% colnames(met.df)[2:ncol(met.df)], ] # 46 / 225 +hmdb.CCLE$name <- lapply(hmdb.CCLE$name, tolower) +met.gmt <- DMEA::as_gmt(hmdb.CCLE, "name", "class", min.per.set = 6) +saveRDS(met.gmt, "gmt_HMDB_in_CCLE.rds") +hmdb <- NULL +met.gmt <- readRDS("gmt_HMDB_in_CCLE.rds") + +# increase # of groups with 6+ metabolites +hmdb.CCLE[grep("alpha", hmdb.CCLE$class), ]$class <- "alpha amino acids" +met.gmt <- DMEA::as_gmt(hmdb.CCLE, "name", "class", min.per.set = 6) +saveRDS(met.gmt, "gmt_HMDB_in_CCLE_2sets.rds") +met.gmt <- readRDS("Inputs/gmt_HMDB_in_CCLE_2sets.rds") + +# met.gmt <- DMEA::as_gmt(hmdb.CCLE, "name", "class", min.per.set = 4) +# saveRDS(met.gmt, "gmt_HMDB_in_CCLE_4minperset.rds") + +#### Step 5a: Fig2: 3 transcriptomic signatures of EGFRi sensitivity #### +types <- c("GSE12790", "GSE31625", "Coldren et al") +data.list <- list("GSE12790" = GSE12790, + "GSE31625" = GSE31625, + "Coldren et al" = Coldren.transcr) +gmt.features <- list(gene.gmt, gene.gmt, gene.gmt) +expression <- list(RNA.df, RNA.df, RNA.df) + +Fig2.panSEA <- panSEA::panSEA(data.list, types, group.names = group.names, + group.samples = group.samples, gmt.features = gmt.features, + expression = expression) +# save results +fig.folder <- "Fig2" +savePanSEA(Fig2.panSEA, fig.folder) +Fig2.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds")) +Fig2.panSEA <- NULL # make space to process next analysis + +#### Step 5b: Fig3: transcriptomics, proteomics, and metabolomics signatures #### +types <- c("transcriptomics", "proteomics", "metabolomics") +data.list <- list(Coldren.transcr, Coldren.prot, Coldren.met) +feature.names <- c("Gene", "Gene", "Metabolite") +gmt.features <- list(gene.gmt, gene.gmt, met.gmt) +prot.df.noNA <- prot.df[, colSums(is.na(prot.df)) == 0] # 5466 gene names +expression <- list(RNA.df, prot.df.noNA, met.df) + +Fig3.panSEA <- panSEA::panSEA(data.list, types, feature.names, + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression) +# proteomics: CCLE prot doesn't contain any of the gene symbols provided (?) +# had to skip line 15 (na.omit for expr) of DMEA::WV +# but then had: Error: id variables not found in data: WV +# it's because the CCLE need to have full coverage of the input gene names + +# save results +setwd(base.path) +savePanSEA(Fig3.panSEA, "Fig3") +Fig3.panSEA <- NULL # make space to process next analysis + +#### Step 5c: Fig4: Fig3 but only querying non-small cell lung cancer cell line data #### +NSCLC.samples <- cell.line.info[cell.line.info$lineage_subtype == "NSCLC", ] # 158 CCLE +NSCLC.RNA.df <- RNA.df[RNA.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 51 CCLE +NSCLC.prot.df <- prot.df[prot.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 63 CCLE +NSCLC.met.df <- met.df[met.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 122 CCLE +NSCLC.prot.df.noNA <- NSCLC.prot.df[, colSums(is.na(NSCLC.prot.df)) == 0] # 5729 gene names +expression <- list(NSCLC.RNA.df, NSCLC.prot.df.noNA, NSCLC.met.df) + +Fig4.panSEA <- panSEA::panSEA(data.list, types, feature.names, + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression) + +# save results +setwd(base.path) +savePanSEA(Fig4.panSEA, "Fig4") +Fig4.panSEA <- NULL # make space to process next analysis + +#### Step 5d: Fig5: Fig3 but only querying lung cancer cell line data #### +lung.samples <- cell.line.info[cell.line.info$lineage == "lung", ] # 273 CCLE +lung.RNA.df <- RNA.df[RNA.df$CCLE_ID %in% lung.samples$CCLE_Name, ] # 63 CCLE +lung.prot.df <- prot.df[prot.df$CCLE_ID %in% lung.samples$CCLE_Name, ] # 78 CCLE +lung.met.df <- met.df[met.df$CCLE_ID %in% lung.samples$CCLE_Name, ] # 182 CCLE +lung.prot.df.noNA <- lung.prot.df[, colSums(is.na(lung.prot.df)) == 0] # 5565 gene names +expression <- list(lung.RNA.df, lung.prot.df.noNA, lung.met.df) + +Fig5.panSEA <- panSEA::panSEA(data.list, types, feature.names, + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression) + +# save results +setwd(base.path) +savePanSEA(Fig5.panSEA, "Fig5") +Fig5.panSEA <- NULL # make space to process next analysis diff --git a/Examples/panSEA_examples_cell_corr.R b/Examples/panSEA_examples_cell_corr.R new file mode 100644 index 0000000..5ef65c8 --- /dev/null +++ b/Examples/panSEA_examples_cell_corr.R @@ -0,0 +1,1057 @@ +# panSEA examples +# Author: Belinda B. Garana (BG) +# Date created: 2023-12-21 +# Last edit: BG 2023-12-21 + +# To recreate: press run through the whole script +# Overview +# 1 - import CCLE data +# 2 - import Coldren et al. data & run differential expression analysis +# 3 - import GSE31625 data & run differential expression analysis +# 4 - import GSE12790 data & run differential expression analysis +# 5 - run panSEA with DMEA_cell_corr +# 6 - run panSEA with DMEA (WV) + +rm(list=ls(all=TRUE)) +library(plyr);library(dplyr);library(GSA);library(panSEA);library(GEOquery) +base.path <- "~/OneDrive - PNNL/Documents/GitHub/panSEA/Examples/" +setwd(paste0(base.path, "Inputs")) + +# function to save results +savePanSEA <- function(panSEA.results, fig.folder, GSEA = TRUE, RDS = TRUE) { + # set file names + DMEA.files <- list("DMEA_results.csv" = + panSEA.results$mDMEA.results[[1]]$compiled.results$results, + "DMEA_mean_results.csv" = + panSEA.results$mDMEA.results[[1]]$compiled.results$mean.results, + "DMEA_correlation_matrix.pdf" = + panSEA.results$mDMEA.results[[1]]$compiled.results$corr.matrix, + "DMEA_venn_diagram.pdf" = + panSEA.results$mDMEA.results[[1]]$compiled.results$venn.diagram, + "DMEA_dot_plot.pdf" = + panSEA.results$mDMEA.results[[1]]$compiled.results$dot.plot, + "DMEA_interactive_network.graph.html" = + panSEA.results$mDMEA.network[[1]]$interactive) + + if (GSEA) { + GSEA.files <- list("GSEA_results.csv" = + panSEA.results$mGSEA.results[[1]]$compiled.results$results, + "GSEA_mean_results.csv" = + panSEA.results$mGSEA.results[[1]]$compiled.results$mean.results, + "GSEA_correlation_matrix.pdf" = + panSEA.results$mGSEA.results[[1]]$compiled.results$corr.matrix, + "GSEA_venn_diagram.pdf" = + panSEA.results$mGSEA.results[[1]]$compiled.results$venn.diagram, + "GSEA_dot_plot.pdf" = + panSEA.results$mGSEA.results[[1]]$compiled.results$dot.plot, + "GSEA_interactive_network.graph.html" = + panSEA.results$mGSEA.network[[1]]$interactive) + all.files <- list('GSEA' = GSEA.files, + 'DMEA' = DMEA.files) + } else { + all.files <- list('DMEA' = DMEA.files) + } + + base.path <- getwd() + dir.create(fig.folder) + setwd(fig.folder) + for (i in 1:length(all.files)) { + # create local folder for subset of results + setwd(paste0(base.path, "/", fig.folder)) + dir.create(names(all.files)[i]) + setwd(names(all.files)[i]) + + # save results locally + temp.files <- all.files[[i]] + + CSV.files <- names(temp.files)[grepl(".csv", names(temp.files))] + for (j in 1:length(CSV.files)) { + write.csv(temp.files[[CSV.files[j]]], CSV.files[j], row.names = FALSE) + } + + PDF.files <- names(temp.files)[grepl(".pdf", names(temp.files))] + for (j in 1:length(PDF.files)) { + ggplot2::ggsave(PDF.files[j], temp.files[[PDF.files[j]]], device = "pdf") + } + + HTML.files <- names(temp.files)[grepl(".html", names(temp.files))] + if (length(HTML.files) > 0) { + for (j in 1:length(HTML.files)) { + visNetwork::visSave(temp.files[[HTML.files[j]]], HTML.files[j]) + } + } + } + setwd(paste0(base.path, "/", fig.folder)) + if (RDS) { + saveRDS(panSEA.results, paste0("panSEA_", fig.folder, ".rds")) + } +} + +##### Step 1: Import CCLE data (PRISM drug AUC, drug moa gmt, RNAseq, proteomics, metabolomics) ##### +#### cell line info (CCLE 19Q4) +cell.line.info <- read.csv(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/CCLE_sample_info.csv") +cell.line.info$X <- NULL + +#### RNAseq (CCLE 19Q4) for 327 adherent cancer cell lines +download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin", + destfile = paste0(getwd(),"/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin")) +load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin") +download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin", + destfile = paste0(getwd(),"/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin")) +load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin") +RNA.df <- rbind(RNA.first200, RNA.rest) +RNA.first200 <- NULL +RNA.rest <- NULL + +#### proteomics (CCLE from IMPROVE) +download.file("https://figshare.com/ndownloader/files/41466702", "proteomics.csv.gz") +prot.df <- read.csv(gzfile("proteomics.csv.gz"),fileEncoding="UTF-16LE") + +allgenes = readr::read_csv("https://figshare.com/ndownloader/files/40576109") +genes = allgenes|> + dplyr::select(gene_symbol,entrez_id)|> + dplyr::distinct() +genes <- genes[genes$gene_symbol %in% colnames(RNA.df)[2:ncol(RNA.df)], ] + +allsamples = readr::read_csv('https://figshare.com/ndownloader/files/40576103') +CCLE.samples <- dplyr::distinct(allsamples[allsamples$id_source == "CCLE", + c("other_id","improve_sample_id")]) + +# merge prot.df with genes, samples to stop using improve IDs +prot.df <- merge(prot.df, CCLE.samples) +prot.df <- merge(prot.df, genes) +prot.df$entrez_id <- NULL +prot.df <- dplyr::distinct(prot.df) + +# convert to wide format for DMEA +prot.df <- reshape2::dcast(prot.df, other_id ~ gene_symbol, mean, + value.var = "proteomics") +colnames(prot.df)[1] <- "CCLE_ID" + +#### metabolomics (CCLE) +met.df <- read.csv(paste0("~/OneDrive - PNNL/Documents/GitHub/panSEA/Examples/", + "Inputs/CCLE_metabolomics_20190502.csv")) +met.df$DepMap_ID <- NULL + +Sys.setenv("VROOM_CONNECTION_SIZE"=300000) # increase connection buffer size +setwd(base.path) +##### Step 2: Coldren et al (EGFR inhibitor ) ##### +### Identify sensitive (SENS) or resistant (RES) cells +### based on Coldren et al, 2006 paper +SENS.cells <- c("NCIH358","NCIH322C","CALU3","NCIH1334","NCIH1648", + "HCC827","HCC78","NCIH2126","HCC193","HCC95", + "NCIH3255","HCC4006","NCIH2009","NCIH1650","NCIH820","NCIH1975") +RES.cells <- c("NCIH125","NCIH1703","A549","NCIH157","NCIH460","NCIH520", + "HCC44","HCC15","NCIH157","NCIH1299","HCC2279") +SENS.cell.info <- cell.line.info[cell.line.info$stripped_cell_line_name %in% SENS.cells,] +SENS.stripped_cell_line_name <- SENS.cell.info$stripped_cell_line_name +# 12 SENS cell lines: "HCC827", "NCIH1650", "HCC4006", "NCIH3255", "CALU3", +# "HCC95", "HCC78", "NCIH1975", "NCIH1648", "NCIH2126", "NCIH358", "NCIH2009" + +RES.cell.info <- cell.line.info[cell.line.info$stripped_cell_line_name %in% RES.cells,] +RES.stripped_cell_line_name <- RES.cell.info$stripped_cell_line_name +# 8 RES cell lines: "NCIH520", "NCIH460", "NCIH1299", "HCC44", "A549", +# "HCC2279", "NCIH1703", "HCC15" + +# Coldren.samples <- list(seq(2, length.out = length(SENS.stripped_cell_line_name)), +# seq((length(SENS.stripped_cell_line_name) + 2), +# length.out = length(RES.stripped_cell_line_name))) + +Coldren.sample.IDs <- CCLE.samples[CCLE.samples$other_id %in% + c(SENS.cell.info$CCLE_Name, + RES.cell.info$CCLE_Name),] +colnames(Coldren.sample.IDs)[1] <- "CCLE_Name" # change other_id to CCLE_Name +Coldren.sample.IDs <- merge(Coldren.sample.IDs, cell.line.info) +# Coldren.SENS.IDs <- Coldren.sample.IDs[Coldren.sample.IDs$CCLE_Name %in% +# SENS.cell.info$CCLE_Name, +# c("improve_sample_id", "CCLE_ID")] +# Coldren.RES.IDs <- Coldren.sample.IDs[Coldren.sample.IDs$CCLE_Name %in% +# RES.cell.info$CCLE_Name, +# c("improve_sample_id", "CCLE_ID")] + +### Get data for SENS and RES cells +## transcriptomics +SENS.data <- RNA.df[RNA.df$CCLE_ID %in% SENS.cell.info$CCLE_Name, ] +# 5 SENS cell lines: "NCIH1650_LUNG", "HCC95_LUNG", "NCIH1975_LUNG", +# "NCIH1648_LUNG", "NCIH2126_LUNG" +rownames(SENS.data) <- SENS.data$CCLE_ID +SENS.data$CCLE_ID <- NULL + +RES.data <- RNA.df[RNA.df$CCLE_ID %in% RES.cell.info$CCLE_Name, ] +# 7 cell lines: "NCIH520_LUNG", "NCIH460_LUNG", "NCIH1299_LUNG", "HCC44_LUNG", +# "A549_LUNG", "NCIH1703_LUNG", "HCC15_LUNG" +rownames(RES.data) <- RES.data$CCLE_ID +RES.data$CCLE_ID <- NULL + +data.SENS <- t(SENS.data) +data.RES <- t(RES.data) +Coldren.transcr <- as.data.frame(cbind(data.SENS,data.RES)) +Coldren.transcr$Gene <- rownames(Coldren.transcr) +Coldren.transcr <- Coldren.transcr[ , c("Gene", + colnames(Coldren.transcr)[ + 1:(ncol(Coldren.transcr)-1)])] + +# compile data into list for panSEA input +all.Coldren.CCLE_IDs <- colnames(Coldren.transcr)[2:ncol(Coldren.transcr)] +all.Coldren.names <- c("H1650", "HCC95", "H1975", "H1648", "H2126", "H520", + "H460", "H1299", "HCC44", "A549", "H1703", "HCC15") +Coldren <- list() +for (i in 2:ncol(Coldren.transcr)) { + temp.df <- Coldren.transcr[ , c(1, i)] + colnames(temp.df)[2] <- "Input" + Coldren[[all.Coldren.names[i-1]]] <- temp.df +} + +## proteomics +SENS.data <- prot.df[prot.df$CCLE_ID %in% SENS.cell.info$CCLE_Name, ] +rownames(SENS.data) <- SENS.data$CCLE_ID +SENS.data$CCLE_ID <- NULL +# 8 cell lines: "HCC827_LUNG", "HCC95_LUNG", "NCIH1650_LUNG", "NCIH1975_LUNG", +# "NCIH2009_LUNG", "NCIH2126_LUNG", "NCIH3255_LUNG", "NCIH358_LUNG" + +RES.data <- prot.df[prot.df$CCLE_ID %in% RES.cell.info$CCLE_Name, ] +rownames(RES.data) <- RES.data$CCLE_ID +RES.data$CCLE_ID <- NULL +# 7 cell lines: "A549_LUNG", "HCC15_LUNG", "HCC44_LUNG", "NCIH1299_LUNG", +# "NCIH1703_LUNG", "NCIH460_LUNG", "NCIH520_LUNG" + +data.SENS <- t(SENS.data) +data.RES <- t(RES.data) +Coldren.prot <- as.data.frame(cbind(data.SENS,data.RES)) +Coldren.prot$Gene <- rownames(Coldren.prot) +Coldren.prot <- Coldren.prot[ , c("Gene", + colnames(Coldren.prot)[ + 1:(ncol(Coldren.prot)-1)])] + +all.Coldren.prot.CCLE_IDs <- colnames(Coldren.prot)[2:ncol(Coldren.prot)] +all.Coldren.prot.names <- c("HCC827", "HCC95", "H1650", "H1975", "H2009", + "H2126", "H3255", "H358", "A549", "HCC15", "HCC44", + "H1299", "H1703", "H460", "H520") +# compile data into list for panSEA input +Coldren.prot.list <- list() +for (i in 2:ncol(Coldren.prot)) { + temp.df <- Coldren.prot[ , c(1, i)] + colnames(temp.df)[2] <- "Input" + Coldren.prot.list[[all.Coldren.prot.names[i-1]]] <- temp.df +} + +## metabolomics +SENS.data <- met.df[met.df$CCLE_ID %in% SENS.cell.info$CCLE_Name, ] +rownames(SENS.data) <- SENS.data$CCLE_ID +SENS.data$CCLE_ID <- NULL +# 12 cell lines: "NCIH358_LUNG", "NCIH1650_LUNG", "HCC95_LUNG", +# "NCIH3255_LUNG", "NCIH1648_LUNG", "NCIH1975_LUNG", "HCC78_LUNG", +# "NCIH2126_LUNG", "HCC827_LUNG", "CALU3_LUNG", "NCIH2009_LUNG", "HCC4006_LUNG" + +RES.data <- met.df[met.df$CCLE_ID %in% RES.cell.info$CCLE_Name, ] +rownames(RES.data) <- RES.data$CCLE_ID +RES.data$CCLE_ID <- NULL +# 8 cell lines: "HCC2279_LUNG", "NCIH520_LUNG", "HCC15_LUNG", "NCIH460_LUNG", +# "A549_LUNG", "HCC44_LUNG", "NCIH1703_LUNG", "NCIH1299_LUNG" + +data.SENS <- t(SENS.data) +data.RES <- t(RES.data) +Coldren.met <- as.data.frame(cbind(data.SENS,data.RES)) +Coldren.met$Metabolite <- rownames(Coldren.met) +Coldren.met <- Coldren.met[ , c("Metabolite", + colnames(Coldren.met)[ + 1:(ncol(Coldren.met)-1)])] + +all.Coldren.met.CCLE_IDs <- colnames(Coldren.met)[2:ncol(Coldren.met)] +all.Coldren.met.names <- c("H358", "H1650", "HCC95", "H3255", "H1648", + "H1975", "HCC78", "H2126", "HCC827", "CALU3", + "H2009", "HCC4006", "HCC2279", "H520", "HCC15", + "H460", "A549", "HCC44", "H1703", "H1299") +# compile data into list for panSEA input +Coldren.met.list <- list() +for (i in 2:ncol(Coldren.met)) { + temp.df <- Coldren.met[ , c(1, i)] + colnames(temp.df)[2] <- "Input" + Coldren.met.list[[all.Coldren.met.names[i-1]]] <- temp.df +} + +##### Step 3: GSE31625 (EGFR inhibitor) ##### +# load series and platform data from GEO +gset <- getGEO("GSE31625", GSEMatrix =TRUE, AnnotGPL=TRUE) +if (length(gset) > 1) idx <- grep("GPL570", attr(gset, "names")) else idx <- 1 +gset <- gset[[idx]] + +# make proper column names to match toptable +fvarLabels(gset) <- make.names(fvarLabels(gset)) + +# group membership for all samples +gsms <- paste0("X11111111XXXXXXXXX0000000XXXXXXXX0000X0000001111") # 0 is phenotype of numerator in FC; 1 of denominator; X: excluded +sml <- strsplit(gsms, split="")[[1]] + +# filter out excluded samples (marked as "X") +sel <- which(sml != "X") +sml <- sml[sel] +gset <- gset[ ,sel] + +# log2 transformation +ex <- exprs(gset) +qx <- as.numeric(quantile(ex, c(0., 0.25, 0.5, 0.75, 0.99, 1.0), na.rm=T)) +LogC <- (qx[5] > 100) || + (qx[6]-qx[1] > 50 && qx[2] > 0) +if (LogC) { ex[which(ex <= 0)] <- NaN +exprs(gset) <- log2(ex) } + +SENS.expr <- as.data.frame(exprs(gset[,which(sml==0)])) +RES.expr <- as.data.frame(exprs(gset[,which(sml==1)])) +SENS.GSE31625 <- colnames(SENS.expr) +# matches with "H1650-8", "H1650-9", "H1650-H", "H1650A", "H1650B", "H1650C", +# "H1650p8", "H3255_1", "H3255_2", "H3255_3", "H32551-Dec", "PC-9_7", "PC-9_8", +# "PC-9_9", "PC-9_10", "PC9", "PC92-4val" on GEO +SENS.GSE31625.names <- c("H1650_1", "H1650_2", "H1650_3", "H1650_4", "H1650_5", + "H1650_6", "H1650_7", "H3255_1", "H3255_2", "H3255_3", + "H3255_4", "PC9_1", "PC9_2", "PC9_3", "PC9_4", "PC9_5", + "PC9_6") +colnames(SENS.expr) <- SENS.GSE31625.names + +RES.GSE31625 <- colnames(RES.expr) +# matches with "A549B", "A549C", "A549-3.05", "A549p2", "A549p3", "A549p4", +# "A549p5", "A549p6", "UKY-29_4", "UKY-29_5", "UKY-29_6", "UKY29-3" on GEO +RES.GSE31625.names <- c("A549_1", "A549_2", "A549-3", "A549_4", "A549_5", + "A549_6", "A549_7", "A549_8", "UKY29_1", "UKY29_2", + "UKY29_3", "UKY29_4") +colnames(RES.expr) <- RES.GSE31625.names + +GSE31625.df <- cbind(SENS.expr, RES.expr) +GSE31625.df$Gene <- rownames(GSE31625.df) +GSE31625.df <- GSE31625.df[ , c("Gene", + colnames(GSE31625.df)[ + 1:(ncol(GSE31625.df)-1)])] + +all.GSE31625.names <- c(SENS.GSE31625.names, RES.GSE31625.names) +GSE31625.names <- c("H1650", "H3255", "PC9", "A549", "UKY29") +GSE31625.CCLE_IDs <- c("NCIH1650_LUNG", "NCIH3255_LUNG", "PC9_LUNG", + "A549_LUNG") +all.GSE31625.CCLE_IDs <- c() +for (i in 1:length(all.GSE31625.names)) { + if (grepl(GSE31625.names[1], all.GSE31625.names[i])) { + all.GSE31625.CCLE_IDs <- c(all.GSE31625.CCLE_IDs, GSE31625.CCLE_IDs[1]) + } else if (grepl(GSE31625.names[2], all.GSE31625.names[i])) { + all.GSE31625.CCLE_IDs <- c(all.GSE31625.CCLE_IDs, GSE31625.CCLE_IDs[2]) + } else if (grepl(GSE31625.names[3], all.GSE31625.names[i])) { + all.GSE31625.CCLE_IDs <- c(all.GSE31625.CCLE_IDs, GSE31625.CCLE_IDs[3]) + } else if (grepl(GSE31625.names[4], all.GSE31625.names[i])) { + all.GSE31625.CCLE_IDs <- c(all.GSE31625.CCLE_IDs, GSE31625.CCLE_IDs[4]) + } else { + all.GSE31625.CCLE_IDs <- c(all.GSE31625.CCLE_IDs, NA) + } +} + +# compile data into list for panSEA input +GSE31625 <- list() +for (i in 2:ncol(GSE31625.df)) { + temp.df <- GSE31625.df[ , c(1, i)] + colnames(temp.df)[2] <- "Input" + GSE31625[[colnames(GSE31625.df)[i]]] <- temp.df +} +temp.df <- NULL + +##### Step 4: GSE12790 (EGFR inhibitor) ##### +# load series and platform data from GEO +gset <- getGEO("GSE12790", GSEMatrix =TRUE, AnnotGPL=TRUE) +if (length(gset) > 1) idx <- grep("GPL570", attr(gset, "names")) else idx <- 1 +gset <- gset[[idx]] + +# make proper column names to match toptable +fvarLabels(gset) <- make.names(fvarLabels(gset)) + +# group membership for all samples +gsms <- paste0("XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX1XX", + "X0X11X1XX1X1X1XX1XX1X1110X1XX1XXX11X1XX0XX1XXXXX") # 0 is phenotype of numerator in FC; 1 of denominator; X: excluded +sml <- strsplit(gsms, split="")[[1]] + +# filter out excluded samples (marked as "X") +sel <- which(sml != "X") +sml <- sml[sel] +gset <- gset[ ,sel] + +# log2 transformation +ex <- exprs(gset) +qx <- as.numeric(quantile(ex, c(0., 0.25, 0.5, 0.75, 0.99, 1.0), na.rm=T)) +LogC <- (qx[5] > 100) || + (qx[6]-qx[1] > 50 && qx[2] > 0) +if (LogC) { ex[which(ex <= 0)] <- NaN +exprs(gset) <- log2(ex) } +SENS.expr <- as.data.frame(exprs(gset[,which(sml==0)])) +RES.expr <- as.data.frame(exprs(gset[,which(sml==1)])) +SENS.GSE12790 <- colnames(SENS.expr) +# matches with "breast cancer cell line_HCC1806", +# "breast cancer cell line_CAL85-1", "breast cancer cell line_HDQ-P1" on GEO +SENS.GSE12790.names <- c("HCC1806", "CAL851", "HDQ-P1") +colnames(SENS.expr) <- SENS.GSE12790.names + +RES.GSE12790 <- colnames(RES.expr) +# matches with "breast cancer cell line_BT20", "breast cancer cell line_BT474", +# "breast cancer cell line_BT483", "breast cancer cell line_CAMA-1", +# "breast cancer cell line_MCF7", "breast cancer cell line_MDA-MB-231", +# "breast cancer cell line_MDA-MB-231", "breast cancer cell line_MDA-MB-453", +# "breast cancer cell line_T47D", "breast cancer cell line_ZR75-1", +# "breast cancer cell line_CAL-120", "breast cancer cell line_CAL-51", +# "breast cancer cell line_EFM-192A", "breast cancer cell line_KPL1", +# "breast cancer cell line_HCC1428", "breast cancer cell line_HCC1954", +# "breast cancer cell line_HCC1500", "breast cancer cell line_HCC1569" on GEO +RES.GSE12790.names <- c("BT20", "BT474", "BT483", "CAMA-1", "MCF7", + "MDAMB231_1", "MDAMB231_2", "MDAMB453", "T47D", + "ZR751", "CAL120", "CAL51", "EFM192A", "KPL1", + "HCC1428", "HCC1954", "HCC1500", "HCC1569") +colnames(RES.expr) <- RES.GSE12790.names + +GSE12790.df <- cbind(SENS.expr, RES.expr) +GSE12790.df$Gene <- rownames(GSE12790.df) +GSE12790.df <- GSE12790.df[ , c("Gene", + colnames(GSE12790.df)[ + 1:(ncol(GSE12790.df)-1)])] + +all.GSE12790.names <- c(SENS.GSE12790.names, RES.GSE12790.names) +GSE12790.names <- c("HCC1806", "CAL851", "HDQ-P1", "BT20", "BT474", "BT483", + "CAMA1", "MCF7", "MDAMB231", "MDAMB453", "T47D", + "ZR751", "CAL120", "CAL51", "EFM192A", "KPL1", + "HCC1428", "HCC1954", "HCC1500", "HCC1569") +GSE12790.CCLE_IDs <- c("HCC1806_BREAST", "CAL851_BREAST", "HDQP1_BREAST", + "BT20_BREAST", "BT474_BREAST", "BT483_BREAST", + "CAMA1_BREAST", "MCF7_BREAST", "MDAMB231_BREAST", + "MDAMB453_BREAST", "T47D_BREAST", "ZR751_BREAST", + "CAL120_BREAST", "CAL51_BREAST", "EFM192A_BREAST", + "KPL1_BREAST", "HCC1428_BREAST", "HCC1954_BREAST", + "HCC1500_BREAST", "HCC1569_BREAST") +all.GSE12790.CCLE_IDs <- c() +for (i in 1:length(all.GSE12790.names)) { + match <- FALSE + for (j in 1:length(GSE12790.names)) { + if (grepl(GSE12790.names[j], all.GSE12790.names[i])) { + all.GSE12790.CCLE_IDs <- c(all.GSE12790.CCLE_IDs, GSE12790.CCLE_IDs[j]) + match <- TRUE + break + } + } + if (!match) { + all.GSE12790.CCLE_IDs <- c(all.GSE12790.CCLE_IDs, NA) + } +} + +# compile data into list for panSEA input +GSE12790 <- list() +for (i in 2:ncol(GSE12790.df)) { + temp.df <- GSE12790.df[ , c(1, i)] + colnames(temp.df)[2] <- "Input" + GSE12790[[colnames(GSE12790.df)[i]]] <- temp.df +} +temp.df <- NULL + +##### Step 5: run panSEA ##### +dir.create("cell_corr") +setwd("cell_corr") +# IMPORTANT: each group must have the same # & position of samples across data sets +# e.g. "Sensitive" samples must be in the same columns across input data.list +# but "Resistant" could have different # as "Sensitive" hypothetically +group.names <- "Sensitive or Resistant" +group.samples <- 2 + +# get gene set info +msigdb.info <- msigdbr::msigdbr("Homo sapiens", "C2", "CP:KEGG") + +# extract necessary info into data frame +msigdb.info <- as.data.frame(msigdb.info[, c( + "gene_symbol", + "gs_name", + "gs_description" +)]) + +gene.gmt <- DMEA::as_gmt( + msigdb.info, "gene_symbol", "gs_name", min.per.set = 6, + descriptions = "gs_description") +saveRDS(gene.gmt, "gmt_MSigDB_Homo-sapiens_C2_CP:KEGG.rds") +gene.gmt <- readRDS("Inputs/gmt_MSigDB_Homo-sapiens_C2_CP:KEGG.rds") +gene.gmt <- readRDS("gmt_MSigDB_Homo-sapiens_C2_CP:KEGG.rds") + +# get metabolite set info +# based on hmdb v5.0 downloaded 20231220: https://hmdb.ca/downloads +hmdb <- XML::xmlToDataFrame("hmdb_metabolites.xml") +saveRDS(hmdb, "hmdb_metabolites_dataframe.rds") +hmdb <- readRDS("hmdb_metabolites_dataframe.rds") +#hmdb$class <- sub(".*belongs to the class of organic compounds known as (.+)\\..*", "\\1", hmdb$taxonomy) +hmdb$class <- NA +hmdb$class <- stringr::str_match(hmdb$taxonomy, "belongs to the class of organic compounds known as\\s*(.*?)\\s*\\. ")[ , 2] +#inorganic.hmdb <- hmdb[is.na(hmdb$class), ] # 72291 / 217920 +hmdb[is.na(hmdb$class), ]$class <- + stringr::str_match( + hmdb[is.na(hmdb$class), ]$taxonomy, + "belongs to the class of inorganic compounds known as\\s*(.*?)\\s*\\. ")[ , 2] +#unclassified.hmdb <- hmdb[is.na(hmdb$class), ] # 71984 / 217920 +#nonblank.unclassified.hmdb <- unclassified.hmdb[unclassified.hmdb$taxonomy != "\n ", ] # 1 / 71984 +hmdb[is.na(hmdb$class), ]$class <- + stringr::str_match( + hmdb[is.na(hmdb$class), ]$taxonomy, + "belongs to the class of chemical entities known as\\s*(.*?)\\s*\\. ")[ , 2] +#unclassified.hmdb <- hmdb[is.na(hmdb$class), ] # 71983 / 217920 +saveRDS(hmdb, "hmdb_metabolites_dataframe_with_class.rds") +hmdb <- readRDS("hmdb_metabolites_dataframe_with_class.rds") +hmdb <- dplyr::distinct(na.omit(hmdb[ , c("name", "class")])) # 145937 metabolites + +met.gmt <- DMEA::as_gmt(hmdb, "name", "class", min.per.set = 6) +saveRDS(met.gmt, "gmt_HMDB.rds") + +hmdb <- readRDS("hmdb_metabolites_dataframe_with_class.rds") +hmdb <- dplyr::distinct(na.omit(hmdb[ , c("name", "class")])) # 145937 metabolites +# hmdb.wide <- reshape2::dcast(hmdb, class ~ name) +# hmdb.match <- colnames(hmdb.wide)[tolower(colnames(hmdb.wide)) %in% colnames(met.df)[2:ncol(met.df)]] # 46 / 225 +hmdb.CCLE <- hmdb[tolower(hmdb$name) %in% colnames(met.df)[2:ncol(met.df)], ] # 46 / 225 +hmdb.CCLE$name <- lapply(hmdb.CCLE$name, tolower) +met.gmt <- DMEA::as_gmt(hmdb.CCLE, "name", "class", min.per.set = 6) +saveRDS(met.gmt, "gmt_HMDB_in_CCLE.rds") +hmdb <- NULL +met.gmt <- readRDS("gmt_HMDB_in_CCLE.rds") + +# increase # of groups with 6+ metabolites +hmdb.CCLE[grep("alpha", hmdb.CCLE$class), ]$class <- "alpha amino acids" +met.gmt <- DMEA::as_gmt(hmdb.CCLE, "name", "class", min.per.set = 6) +saveRDS(met.gmt, "gmt_HMDB_in_CCLE_2sets.rds") +met.gmt <- readRDS("Inputs/gmt_HMDB_in_CCLE_2sets.rds") +met.gmt <- readRDS("gmt_HMDB_in_CCLE_2sets.rds") + +# met.gmt <- DMEA::as_gmt(hmdb.CCLE, "name", "class", min.per.set = 4) +# saveRDS(met.gmt, "gmt_HMDB_in_CCLE_4minperset.rds") + +#### Step 5a: GSE12790 #### +gmt.features <- list() +expression <- list() +for (i in 1:length(all.GSE12790.names)) { + gmt.features[[all.GSE12790.names[i]]] <- gene.gmt + expression[[all.GSE12790.names[i]]] <- RNA.df[ + RNA.df$CCLE_ID != all.GSE12790.CCLE_IDs[i], ] +} + +Fig2.panSEA <- panSEA::panSEA(GSE12790, all.GSE12790.names, GSEA = FALSE, + GSEA.rank.var = rep("Input", length(GSE12790)), + DMEA.type = "cell_corr", + group.names = group.names, + group.samples = group.samples, + #gmt.features = gmt.features, + expression = expression, + scatter.plots = FALSE) + +# Loading PRISM drug sensitivity AUC scores +# Loading PRISM drug mechanism of action annotations +# Read 85 records +# Read 3655 items +# 123456789101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960616263646566676869707172737475767778798081828384851 +# 2 +# 3 +# 4 +# 5 +# 6 +# 7 +# 8 +# 9 +# 10 +# 11 +# 12 +# 13 +# 14 +# 15 +# 16 +# 17 +# 18 +# 19 +# 20 +# 21 +# 22 +# 23 +# 24 +# 25 +# 26 +# 27 +# 28 +# 29 +# 30 +# 31 +# 32 +# 33 +# 34 +# 35 +# 36 +# 37 +# 38 +# 39 +# 40 +# 41 +# 42 +# 43 +# 44 +# 45 +# 46 +# 47 +# 48 +# 49 +# 50 +# 51 +# 52 +# 53 +# 54 +# 55 +# 56 +# 57 +# 58 +# 59 +# 60 +# 61 +# 62 +# 63 +# 64 +# 65 +# 66 +# 67 +# 68 +# 69 +# 70 +# 71 +# 72 +# 73 +# 74 +# 75 +# 76 +# 77 +# 78 +# 79 +# 80 +# 81 +# 82 +# 83 +# 84 +# Running DMEA using HCC1806 data +# Running correlations and regressions... +# Error in `[.data.frame`(all.data.corr, , 3:ncol(all.data.corr)) : +# undefined columns selected + +# save results +fig.folder <- "Fig2" +savePanSEA(Fig2.panSEA, fig.folder) +#Fig2.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds")) +Fig2.panSEA <- NULL # make space to process next analysis + +#### Step 5b: GSE31625 #### +gmt.features <- list() +expression <- list() +for (i in 1:length(all.GSE31625.names)) { + gmt.features[[all.GSE31625.names[i]]] <- gene.gmt + expression[[all.GSE31625.names[i]]] <- RNA.df[ + RNA.df$CCLE_ID != all.GSE31625.CCLE_IDs[i], ] +} + +Fig3.panSEA <- panSEA::panSEA(GSE31625, all.GSE31625.names, GSEA = FALSE, + GSEA.rank.var = rep("Input", length(GSE31625)), + DMEA.type = "cell_corr", + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression, + scatter.plots = FALSE) +# not doing GSEA because not enough sets for H1650_1 sample +# again DMEA issue with H1650_1: +# Running DMEA using H1650_1 data +# Running correlations and regressions... +# Error in `[.data.frame`(all.data.corr, , 3:ncol(all.data.corr)) : +# undefined columns selected + +# try removing H1650_1 +GSE31625v2 <- GSE31625[2:length(GSE31625)] +all.GSE31625.namesv2 <- all.GSE31625.names[2:length(all.GSE31625.names)] +gmt.featuresv2 <- gmt.features[2:length(gmt.features)] +expressionv2 <- expression[2:length(expression)] + +Fig3.panSEA <- panSEA::panSEA(GSE31625v2, all.GSE31625.namesv2, GSEA = FALSE, + GSEA.rank.var = rep("Input", length(GSE31625v2)), + DMEA.type = "cell_corr", + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.featuresv2, + expression = expressionv2, + scatter.plots = FALSE) + +# realized it was because gene ids are not gene symbols +# save results +fig.folder <- "Fig3_GSE31625" +setwd(base.path) +setwd("cell_corr") +savePanSEA(Fig3.panSEA, fig.folder, GSEA = FALSE) +#Fig3.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds")) +Fig3.panSEA <- NULL # make space to process next analysis + +#### Step 5c: Coldren #### +gmt.features <- list() +expression <- list() +for (i in 1:length(all.Coldren.names)) { + gmt.features[[all.Coldren.names[i]]] <- gene.gmt + expression[[all.Coldren.names[i]]] <- RNA.df[ + RNA.df$CCLE_ID != all.Coldren.CCLE_IDs[i], ] +} + +Fig4.panSEA <- panSEA::panSEA(Coldren, all.Coldren.names, + GSEA.rank.var = rep("Input", length(Coldren)), + DMEA.type = "cell_corr", + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression) +# save results +fig.folder <- "Fig4" +savePanSEA(Fig4.panSEA, fig.folder) +#Fig4.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds")) +Fig4.panSEA <- NULL # make space to process next analysis + +#### Step 5d: Coldren proteomics #### +gmt.features <- list() +expression <- list() +for (i in 1:length(all.Coldren.prot.names)) { + gmt.features[[all.Coldren.prot.names[i]]] <- gene.gmt + expression[[all.Coldren.prot.names[i]]] <- prot.df[ + prot.df$CCLE_ID != all.Coldren.prot.CCLE_IDs[i], ] +} + +Fig5.panSEA <- panSEA::panSEA(Coldren.prot.list, all.Coldren.prot.names, + GSEA.rank.var = rep("Input", + length(Coldren.prot.list)), + DMEA.type = "cell_corr", + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression) +# save results +fig.folder <- "Fig5" +setwd(base.path) +setwd("cell_corr") +savePanSEA(Fig5.panSEA, fig.folder) +#Fig5.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds")) +Fig5.panSEA <- NULL # make space to process next analysis + +#### Step 5e: Coldren metabolomics #### +gmt.features <- list() +expression <- list() +for (i in 1:length(all.Coldren.met.names)) { + gmt.features[[all.Coldren.met.names[i]]] <- met.gmt + expression[[all.Coldren.met.names[i]]] <- met.df[ + met.df$CCLE_ID != all.Coldren.met.CCLE_IDs[i], ] +} + +Fig6.panSEA <- panSEA::panSEA(Coldren.met.list, all.Coldren.met.names, + feature.names = rep("Metabolite", length(Coldren.met.list)), + GSEA.rank.var = rep("Input", + length(Coldren.met.list)), + DMEA.type = "cell_corr", + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression, + scatter.plots = FALSE) +# save results +fig.folder <- "Fig6" +setwd(base.path) +setwd("cell_corr") +savePanSEA(Fig6.panSEA, fig.folder) +#Fig6.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds")) +Fig6.panSEA <- NULL # make space to process next analysis + +#### Step 5f: Coldren but only querying non-small-cell lung cancer cell line data #### +NSCLC.samples <- cell.line.info[cell.line.info$lineage_subtype == "NSCLC", ] # 273 CCLE +NSCLC.RNA.df <- RNA.df[RNA.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 63 CCLE +NSCLC.prot.df <- prot.df[prot.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 78 CCLE +NSCLC.met.df <- met.df[met.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 182 CCLE +NSCLC.prot.df.noNA <- NSCLC.prot.df[, colSums(is.na(NSCLC.prot.df)) == 0] # 5565 gene names + +gmt.features <- list() +expression <- list() +for (i in 1:length(all.Coldren.names)) { + gmt.features[[all.Coldren.names[i]]] <- gene.gmt + expression[[all.Coldren.names[i]]] <- NSCLC.RNA.df[ + NSCLC.RNA.df$CCLE_ID != all.Coldren.CCLE_IDs[i], ] +} + +Fig7.panSEA <- panSEA::panSEA(Coldren, all.Coldren.names, + GSEA.rank.var = rep("Input", length(Coldren)), + DMEA.type = "cell_corr", + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression, + scatter.plots = FALSE) + +# save results +setwd(base.path) +setwd("cell_corr") +savePanSEA(Fig7.panSEA, "Fig7_Coldren_transcr_NSCLC") +Fig7.panSEA <- NULL # make space to process next analysis + +#### Step 5g: Coldren proteomics but only querying non-small-cell lung cancer cell line data #### +gmt.features <- list() +expression <- list() +for (i in 1:length(all.Coldren.prot.names)) { + gmt.features[[all.Coldren.prot.names[i]]] <- gene.gmt + expression[[all.Coldren.prot.names[i]]] <- NSCLC.prot.df.noNA[ + NSCLC.prot.df.noNA$CCLE_ID != all.Coldren.prot.CCLE_IDs[i], ] +} + +Fig8.panSEA <- panSEA::panSEA(Coldren.prot.list, all.Coldren.prot.names, + GSEA.rank.var = rep("Input", + length(Coldren.prot.list)), + DMEA.type = "cell_corr", + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression, + scatter.plots = FALSE) + +# save results +setwd(base.path) +setwd("cell_corr") +savePanSEA(Fig8.panSEA, "Fig8_Coldren_prot_NSCLC") +Fig8.panSEA <- NULL # make space to process next analysis + +#### Step 5h: Coldren metabolomics but only querying non-small-cell lung cancer cell line data #### +gmt.features <- list() +expression <- list() +for (i in 1:length(all.Coldren.met.names)) { + gmt.features[[all.Coldren.met.names[i]]] <- met.gmt + expression[[all.Coldren.met.names[i]]] <- NSCLC.met.df[ + NSCLC.met.df$CCLE_ID != all.Coldren.met.CCLE_IDs[i], ] +} + +Fig9.panSEA <- panSEA::panSEA(Coldren.met.list, all.Coldren.met.names, + feature.names = rep("Metabolite", length(Coldren.met.list)), + GSEA.rank.var = rep("Input", + length(Coldren.met.list)), + DMEA.type = "cell_corr", + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression, + scatter.plots = FALSE) + +# save results +setwd(base.path) +setwd("cell_corr") +savePanSEA(Fig9.panSEA, "Fig9_Coldren_met_NSCLC") +Fig9.panSEA <- NULL # make space to process next analysis + +##### Step 6: run panSEA with WV ##### +setwd(base.path) +dir.create("ssDMEA_WV") +setwd("ssDMEA_WV") +# IMPORTANT: each group must have the same # & position of samples across data sets +# e.g. "Sensitive" samples must be in the same columns across input data.list +# but "Resistant" could have different # as "Sensitive" hypothetically +group.names <- "Sensitive or Resistant" +group.samples <- 2 + +# get gene set info +gene.gmt <- readRDS("gmt_MSigDB_Homo-sapiens_C2_CP:KEGG.rds") + +# get metabolite set info +met.gmt <- readRDS("gmt_HMDB_in_CCLE_2sets.rds") + +#### Step 6a: GSE12790 #### +gmt.features <- list() +expression <- list() +for (i in 1:length(all.GSE12790.names)) { + gmt.features[[all.GSE12790.names[i]]] <- gene.gmt + expression[[all.GSE12790.names[i]]] <- RNA.df[ + RNA.df$CCLE_ID != all.GSE12790.CCLE_IDs[i], ] +} + +GSE12790.panSEA <- panSEA::panSEA(GSE12790, all.GSE12790.names, GSEA = FALSE, + GSEA.rank.var = rep("Input", length(GSE12790)), + GSEA = FALSE, DMEA.type = "WV", + group.names = group.names, + group.samples = group.samples, + #gmt.features = gmt.features, + expression = expression, + scatter.plots = FALSE) + +# save results +fig.folder <- "GSE12790" +savePanSEA(GSE12790.panSEA, fig.folder) +#GSE12790.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds")) +GSE12790.panSEA <- NULL # make space to process next analysis + +#### Step 6b: GSE31625 #### +gmt.features <- list() +expression <- list() +for (i in 1:length(all.GSE31625.names)) { + gmt.features[[all.GSE31625.names[i]]] <- gene.gmt + expression[[all.GSE31625.names[i]]] <- RNA.df[ + RNA.df$CCLE_ID != all.GSE31625.CCLE_IDs[i], ] +} + +GSE31625.panSEA <- panSEA::panSEA(GSE31625, all.GSE31625.names, + GSEA.rank.var = rep("Input", length(GSE31625)), + GSEA = FALSE, DMEA.type = "WV", + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression, + scatter.plots = FALSE) +# save results +fig.folder <- "GSE31625" +savePanSEA(GSE31625.panSEA, fig.folder) +#GSE31625.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds")) +GSE31625.panSEA <- NULL # make space to process next analysis + +#### Step 6c: Coldren #### +gmt.features <- list() +expression <- list() +for (i in 1:length(all.Coldren.names)) { + gmt.features[[all.Coldren.names[i]]] <- gene.gmt + expression[[all.Coldren.names[i]]] <- RNA.df[ + RNA.df$CCLE_ID != all.Coldren.CCLE_IDs[i], ] +} + +Coldren.panSEA <- panSEA::panSEA(Coldren, all.Coldren.names, + GSEA.rank.var = rep("Input", length(Coldren)), + GSEA = FALSE, DMEA.type = "WV", + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression, + scatter.plots = FALSE) +# save results +fig.folder <- "Coldren" +savePanSEA(Coldren.panSEA, fig.folder, GSEA = FALSE) +#Coldren.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds")) +Coldren.panSEA <- NULL # make space to process next analysis + +#### Step 6d: Coldren proteomics #### +gmt.features <- list() +expression <- list() +for (i in 1:length(all.Coldren.prot.names)) { + gmt.features[[all.Coldren.prot.names[i]]] <- gene.gmt + expression[[all.Coldren.prot.names[i]]] <- prot.df[ + prot.df$CCLE_ID != all.Coldren.prot.CCLE_IDs[i], ] +} + +Coldren.prot.panSEA <- panSEA::panSEA(Coldren.prot.list, all.Coldren.prot.names, + GSEA.rank.var = rep("Input", + length(Coldren.prot.list)), + GSEA = FALSE, DMEA.type = "WV", + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression, scatter.plots = FALSE) +# save results +fig.folder <- "Coldren.prot" +setwd(base.path) +setwd("ssDMEA_WV") +savePanSEA(Coldren.prot.panSEA, fig.folder, GSEA = FALSE) +#Coldren.prot.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds")) +Coldren.prot.panSEA <- NULL # make space to process next analysis + +#### Step 6e: Coldren metabolomics #### +gmt.features <- list() +expression <- list() +for (i in 1:length(all.Coldren.met.names)) { + gmt.features[[all.Coldren.met.names[i]]] <- met.gmt + expression[[all.Coldren.met.names[i]]] <- met.df[ + met.df$CCLE_ID != all.Coldren.met.CCLE_IDs[i], ] +} + +Coldren.met.panSEA <- panSEA::panSEA(Coldren.met.list, all.Coldren.met.names, + feature.names = rep("Metabolite", length(Coldren.met.list)), + GSEA.rank.var = rep("Input", + length(Coldren.met.list)), + GSEA = FALSE, DMEA.type = "WV", + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression, + scatter.plots = FALSE) +# save results +fig.folder <- "Coldren.met" +setwd(base.path) +setwd("ssDMEA_WV") +savePanSEA(Coldren.met.panSEA, fig.folder, GSEA = FALSE) +#Coldren.met.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds")) +Coldren.met.panSEA <- NULL # make space to process next analysis + +#### Step 6f: Coldren but only querying non-small-cell lung cancer cell line data #### +NSCLC.samples <- cell.line.info[cell.line.info$lineage_subtype == "NSCLC", ] # 273 CCLE +NSCLC.RNA.df <- RNA.df[RNA.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 63 CCLE +NSCLC.prot.df <- prot.df[prot.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 78 CCLE +NSCLC.met.df <- met.df[met.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 182 CCLE +NSCLC.prot.df.noNA <- NSCLC.prot.df[, colSums(is.na(NSCLC.prot.df)) == 0] # 5565 gene names + +gmt.features <- list() +expression <- list() +for (i in 1:length(all.Coldren.names)) { + gmt.features[[all.Coldren.names[i]]] <- gene.gmt + expression[[all.Coldren.names[i]]] <- NSCLC.RNA.df[ + NSCLC.RNA.df$CCLE_ID != all.Coldren.CCLE_IDs[i], ] +} + +Coldren.NSCLC.panSEA <- panSEA::panSEA(Coldren, all.Coldren.names, + GSEA.rank.var = rep("Input", length(Coldren)), + GSEA = FALSE, DMEA.type = "WV", + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression, + scatter.plots = FALSE) + +# save results +setwd(base.path) +setwd("ssDMEA_WV") +savePanSEA(Coldren.NSCLC.panSEA, "Coldren_trascr_NSCLC", GSEA = FALSE) +Coldren.NSCLC.panSEA <- NULL # make space to process next analysis + +#### Step 6g: Coldren proteomics but only querying non-small-cell lung cancer cell line data #### +gmt.features <- list() +expression <- list() +for (i in 1:length(all.Coldren.prot.names)) { + gmt.features[[all.Coldren.prot.names[i]]] <- gene.gmt + expression[[all.Coldren.prot.names[i]]] <- NSCLC.prot.df.noNA[ + NSCLC.prot.df.noNA$CCLE_ID != all.Coldren.prot.CCLE_IDs[i], ] +} + +Coldren.NSCLC.prot.panSEA <- panSEA::panSEA(Coldren.prot.list, all.Coldren.prot.names, + GSEA.rank.var = rep("Input", + length(Coldren.prot.list)), + GSEA = FALSE, DMEA.type = "WV", + group.names = group.names, + group.samples = group.samples, + gmt.features = gmt.features, + expression = expression, + scatter.plots = FALSE) + +# save results +setwd(base.path) +setwd("ssDMEA_WV") +savePanSEA(Coldren.NSCLC.prot.panSEA, "Coldren_prot_NSCLC", GSEA = FALSE) +Coldren.NSCLC.prot.panSEA <- NULL # make space to process next analysis + +#### Step 6h: Coldren metabolomics but only querying non-small-cell lung cancer cell line data #### +gmt.features <- list() +expression <- list() +for (i in 1:length(all.Coldren.met.names)) { + gmt.features[[all.Coldren.met.names[i]]] <- met.gmt + expression[[all.Coldren.met.names[i]]] <- NSCLC.met.df[ + NSCLC.met.df$CCLE_ID != all.Coldren.met.CCLE_IDs[i], ] +} + +Coldren.NSCLC.met.panSEA <- panSEA::panSEA(Coldren.met.list, all.Coldren.met.names, + feature.names = rep("Metabolite", length(Coldren.met.list)), + GSEA.rank.var = rep("Input", + 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z|0(0_bsC1DC_J!bWnuKv34!bUkxU4QA|@)aFdzn#IK?8dh3%Azp%Wty(2bFq5%DsN zNJvx&B!n2?I#t><^_C+icFuIZJDiuTx8m=4a=q?7O&_P5yOZ(j&&Jos`@>!Te!TX5 z`}w;P$BE69FEdlBfKr7Nm+)lsxFxT9^^S~=oh6JP*oN=Eg}5N0n7+4;WS!(S=&*FA5OPduzBgHbOi-_xV=L>~F z-~}i{bIk=Hu?va0Mna&aC5;4L2)NVId>^Q(r3En{NJ|S{Xct=2pjU}NH_C^WirPJOCOKnFOx0^o5V5G{|-?Reothm8sk!QMeO3 KoldWR;QRwRAY{P+ literal 0 HcmV?d00001 diff --git a/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_interactive_network.graph.html b/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_interactive_network.graph.html new file mode 100644 index 0000000..60f6cca --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_interactive_network.graph.html @@ -0,0 +1,5318 @@ + + + + +visNetwork + + + + + + + +
+
+
+ + + + diff --git a/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_mean_results.csv b/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..1dffa5b --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"MEK inhibitor",1.837,0.0718258126889007,1.04805803593986e-14,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"A549",4.34944084915044e-13 +"AP inhibitor",1.658,0.161264738208555,3.3671360440357e-10,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"CALU3",6.98680729137407e-09 +"HSP inhibitor",1.4845,0.162204386987204,7.84433373523757e-07,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",5.91890636386107e-06 +"CHK inhibitor",1.459,0.124515904712273,2.49244058868342e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",1.47766120614803e-05 +"bacterial DNA gyrase inhibitor",1.398,0.113721728701895,5.93068477388403e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.000307654272645234 +"estrogen receptor agonist",1.2995,0.0888212279036706,0.00199808555192968,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.00753823185500743 +"thymidylate synthase inhibitor",1.2256,0.188098070725157,0.0130029033245659,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0415092683053451 +"glucocorticoid receptor agonist",1.2007,0.187024653595807,0.0260713767854997,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0769886029780495 +"adrenergic receptor antagonist",1.1705,0.0814652008367279,0.0570644407717307,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.143525714668292 +"proteasome inhibitor",1.1327,0.157606471948331,0.10491171311871,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.248790633967226 +"EGFR inhibitor",1.1262,0.148325602006283,0.127977156233972,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.295058443539436 +"ATPase inhibitor",0.83905,0.115644862447609,0.998061654194559,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"phosphodiesterase inhibitor",0.76505,0.17273846217849,0.999923243164951,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"DNA polymerase inhibitor",0.6789,0.482692110650475,0.999173327925464,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"cytochrome P450 inhibitor",0.62805,0.646229426018834,0.970017345337301,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"tubulin polymerization inhibitor",0.60165,0.537214675799849,0.998994665050148,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"benzodiazepine receptor agonist",0.54955,0.369565958075715,0.999999999956194,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"potassium channel blocker",0.53295,0.618733041234901,0.999579694939796,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"glutamate receptor antagonist",0.466,0.660526902914396,0.999874413399112,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"HCV inhibitor",0.4564,0.679967135428734,0.999807482677365,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"protein synthesis inhibitor",0.4486,0.793560225552508,0.983668059741666,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"src inhibitor",0.3754,0.945900150511058,0.752690881653816,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"RAF inhibitor",0.0822999999999999,0.801939694543306,0.99996382852263,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"PLK inhibitor",-0.01665,0.827688682575253,0.999779321057991,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"DNA methyltransferase inhibitor",-0.03195,0.985599922836207,0.907422784600226,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"microtubule inhibitor",-0.0979,0.591130308904275,0.999999999999991,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"tyrosine kinase inhibitor",-0.33585,0.527821368806172,0.999999999999913,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"RET tyrosine kinase inhibitor",-0.4127,0.78838756832838,0.9972876450892,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"TGF beta receptor inhibitor",-0.4863,0.790787821698949,0.985255632193486,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"ALK tyrosine kinase receptor inhibitor",-0.5731,0.43039833447144,0.999999989123903,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"topoisomerase inhibitor",-0.6991,0.340221584141555,0.999980915607873,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"protein tyrosine kinase inhibitor",-0.70065,0.376475941077948,0.999974859367147,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"NFkB pathway inhibitor",-0.7625,0.162951881822438,0.9999821647786,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"histamine receptor antagonist",-0.76335,0.114108108941984,0.999994692911645,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"cyclooxygenase inhibitor",-0.7705,0.0433620013133012,0.999997319224395,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"ribonucleotide reductase inhibitor",-0.78155,0.0886011019297045,0.999986589116802,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"VEGFR inhibitor",-0.807,0.0794043615400247,0.99995711607612,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"DNA synthesis inhibitor",-0.8334,0.0772394772257378,0.999711085773,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"progesterone receptor agonist",-0.85815,0.0710820689507262,0.999110209679851,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"JAK inhibitor",-0.8592,0.0840711478138418,0.998951201956296,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"PPAR receptor agonist",-0.8788,0.0778166536092845,0.996498089611052,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"DNA alkylating agent",-0.90985,0.0758032598937956,0.988467027005913,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"HMGCR inhibitor",-0.92915,0.515218019769046,0.351644249465577,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.694916016801021 +"PI3K inhibitor",-0.94995,0.0644780460393507,0.952406632479659,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"DNA inhibitor",-0.9703,0.0807172452714445,0.919173511629033,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"dopamine receptor antagonist",-0.9774,0.0688380249877241,0.907873250445604,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"CDK inhibitor",-0.99695,0.228528352496439,0.665560924904876,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"opioid receptor agonist",-1.01205,0.175418439587657,0.713462791798366,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"mTOR inhibitor",-1.0258,0.0899746163034184,0.733392721944979,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"adrenergic receptor agonist",-1.0335,0.109414951350112,0.694733318769849,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"sodium channel blocker",-1.0539,0.0615013050781509,0.599552023234603,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991 +"acetylcholine receptor agonist",-1.0721,0.0859509652130366,0.529611475537834,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.99903982885546 +"CC chemokine receptor antagonist",-1.079,0.186614717081957,0.363867647047123,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.702349179183981 +"KIT inhibitor",-1.10615,0.0745980633303008,0.336461213113685,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.681128797278922 +"BCL inhibitor",-1.11665,0.170836725683049,0.190451749940676,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.400633051217512 +"phosphatase inhibitor",-1.1286,0.0917957687363352,0.193076169261452,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.400633051217512 +"AKT inhibitor",-1.13275,0.170969949652594,0.139538304499633,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.313018358742419 +"p38 MAPK inhibitor",-1.14975,0.0867154299388159,0.143409429021606,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.313236384441929 +"PDGFR tyrosine kinase receptor inhibitor",-1.1715,0.0640127454414147,0.0938326096386162,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.229061958823681 +"MDM inhibitor",-1.19205,0.19130946959807,0.0278272058956806,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0769886029780495 +"antioxidant",-1.19555,0.0894677095528414,0.0541876529562529,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.140549224855281 +"acetylcholine receptor antagonist",-1.2049,0.139171193329049,0.0312283163105961,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0836112985090153 +"growth factor receptor inhibitor",-1.2165,0.0873754753017718,0.0233061897848472,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0716449537830488 +"serotonin receptor antagonist",-1.2215,0.077342369405541,0.0271127185821637,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0769886029780495 +"Bcr.Abl kinase inhibitor",-1.2475,0.122297092963686,0.0101361296128085,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0336519503145243 +"HDAC inhibitor",-1.263,0.121573023323433,0.004788238329597,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0165593242231896 +"Abl kinase inhibitor",-1.267,0.107120198105237,0.00406328611433477,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0146631629343385 +"adenosine receptor antagonist",-1.2915,0.115041182557424,0.00131193028439299,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.00544451068023093 +"glycogen synthase kinase inhibitor",-1.2925,0.0789986675437264,0.00185730876296803,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.00734079177744505 +"retinoid receptor agonist",-1.3245,0.169441031506229,0.000182196746427658,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.000840129441860868 +"vitamin D receptor agonist",-1.328,0.102320446071206,0.000329944258200849,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0014413354437195 +"bacterial 50S ribosomal subunit inhibitor",-1.339,0.0994670006108876,0.000152020199449106,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.000742216267898577 +"calcium channel blocker",-1.4,0.144913767461894,3.35624847546601e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",1.85712415642453e-05 +"androgen receptor antagonist",-1.41,0.15556349186104,2.3420775476773e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",1.47766120614803e-05 +"serotonin receptor agonist",-1.4245,0.0628678647724943,2.26521432280365e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",1.47766120614803e-05 +"sterol demethylase inhibitor",-1.4375,0.129487857589652,2.96178476951966e-07,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",2.45828135870132e-06 +"Aurora kinase inhibitor",-1.4515,0.106290317428011,2.18601397223425e-07,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",2.0159906632827e-06 +"FLT3 inhibitor",-1.457,0.0606196077363196,1.80806381591151e-07,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",1.87586620900819e-06 +"FGFR inhibitor",-1.4725,0.117198661749141,4.13354078350316e-08,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",4.90119835758232e-07 +"PARP inhibitor",-1.479,0.0689698637468798,2.09328525795183e-08,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",2.89571127350003e-07 +"bromodomain inhibitor",-1.49355,0.313164573347625,9.21872485605836e-10,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H358, H520, H460, H1299",1.53030832610569e-08 +"MET inhibitor",-1.5835,0.145973141004559,6.72990294094476e-11,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC95",1.86193981366138e-09 +"estrogen receptor antagonist",-1.7155,0.100758961988761,1.41776750072524e-17,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H3255, HCC15",1.17674702560195e-15 diff --git a/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_results.csv b/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_results.csv new file mode 100644 index 0000000..2a8e021 --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_results.csv @@ -0,0 +1,1661 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"H358","Pearson.est","EGFR inhibitor",0.32984,0.937,0.516,70,0.754,"pelitinib, vandetanib, canertinib, brigatinib, erlotinib, XL.647, BMS.690514, rociletinib, afatinib",0.287350298372789,0.122628654130226,FALSE +"H358","Pearson.est","Abl kinase inhibitor",-0.47766,-1.15,0.28,1109,0.68,"flumatinib, nilotinib, KW.2449, ponatinib, imatinib, tozasertib",0.552841968657781,0.167491087293764,FALSE +"H358","Pearson.est","acetylcholine receptor agonist",-0.40273,-0.966,0.524,945,0.814,"xanomeline, nicotine, nefiracetam, pilocarpine",0.280668713016273,0.0893755951107988,FALSE +"H358","Pearson.est","acetylcholine receptor antagonist",-0.51404,-1.25,0.197,830,0.527,"diphemanil, dicycloverine, iododexetimide, methscopolamine",0.705533773838407,0.278189384787453,FALSE +"H358","Pearson.est","adenosine receptor antagonist",-0.60691,-1.49,0.0556,1227,0.48,"MRS.1220, CGS.15943, SCH.58261",1.25492520841794,0.318758762624413,FALSE +"H358","Pearson.est","adrenergic receptor agonist",-0.40384,-0.969,0.506,1137,0.829,"clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.295849483160201,0.0814454694497265,FALSE +"H358","Pearson.est","adrenergic receptor antagonist",0.38547,1.13,0.273,218,0.763,"prazosin, vincamine, RS.17053, practolol, imiloxan, atenolol...., levobunolol, idazoxan",0.563837352959244,0.11747546204512,FALSE +"H358","Pearson.est","AKT inhibitor",-0.60187,-1.44,0.071,1106,0.463,"GDC.0068, triciribine, ONC201, CCT128930, uprosertib, A.674563",1.14874165128092,0.334419008982047,FALSE +"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.24096,-0.583,0.944,1163,0.951,"AP26113, alectinib, DMH1",0.025028005701931,0.0218194830625861,FALSE +"H358","Pearson.est","androgen receptor antagonist",-0.61522,-1.5,0.0616,995,0.517,"nilutamide, flutamide, bicalutamide",1.21041928783557,0.286509456906058,FALSE +"H358","Pearson.est","antioxidant",-0.45293,-1.12,0.329,1274,0.725,"benfotiamine, trolox",0.482804102050026,0.139661993429006,FALSE +"H358","Pearson.est","AP inhibitor",0.62938,1.81,0.0258,25,0.54,"GDC.0152, birinapant",1.58838029403677,0.267606240177031,FALSE +"H358","Pearson.est","ATPase inhibitor",0.31855,0.903,0.557,124,0.721,"k.strophanthidin, digitoxin, ouabain",0.254144804826271,0.142064735280571,FALSE +"H358","Pearson.est","Aurora kinase inhibitor",-0.63562,-1.52,0.0553,1131,0.543,"CCT137690, CCT129202, KW.2449, ENMD.2076, barasertib.HQPA, AMG900, aurora.a.inhibitor.i, MK.8745, PF.03814735, SNS.314, AT.9283, barasertib, hesperadin, tozasertib",1.2572748686953,0.265200170411153,FALSE +"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.55922,-1.33,0.14,822,0.496,"azithromycin, valnemulin, azalomycin.b, josamycin, tilmicosin, radezolid, dirithromycin",0.853871964321762,0.304518323509803,FALSE +"H358","Pearson.est","bacterial DNA gyrase inhibitor",0.53677,1.55,0.0702,207,0.492,"finafloxacin, sarafloxacin, novobiocin, sparfloxacin",1.15366288787019,0.30803489723264,FALSE +"H358","Pearson.est","BCL inhibitor",-0.5451,-1.32,0.157,1217,0.465,"gossypol, ABT.737",0.804100347590766,0.332547047110046,FALSE +"H358","Pearson.est","Bcr.Abl kinase inhibitor",-0.44341,-1.05,0.405,1109,0.789,"flumatinib, nilotinib, ponatinib, imatinib, tozasertib",0.392544976785331,0.10292299679058,FALSE +"H358","Pearson.est","benzodiazepine receptor agonist",0.22955,0.67,0.887,134,0.908,"gamma.aminobutyric.acid, ZK.93423, eprinomectin",0.0520763801682736,0.0419141514789149,FALSE +"H358","Pearson.est","bromodomain inhibitor",-0.80675,-1.94,0.00254,1192,0.0685,"OTX015, PFI.1, JQ1...., bromosporine, I.BET151",2.59516628338006,1.16430942850757,TRUE +"H358","Pearson.est","calcium channel blocker",-0.64665,-1.57,0.0426,1239,0.594,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.37059040089728,0.226213555018806,FALSE +"H358","Pearson.est","CC chemokine receptor antagonist",-0.51865,-1.27,0.197,1072,0.528,"SB.225002, PF.04136309, navarixin",0.705533773838407,0.277366077466188,FALSE +"H358","Pearson.est","CDK inhibitor",-0.5444,-1.32,0.141,1039,0.465,"TG.02, palbociclib, AZD5438, BMS.265246, NU6027, indisulam, JNJ.7706621, ribociclib, abemaciclib, kenpaullone, indirubin, R547, arcyriaflavin.a",0.85078088734462,0.332547047110046,FALSE +"H358","Pearson.est","CHK inhibitor",0.51553,1.45,0.135,182,0.532,"SCH.900776, CHIR.124, LY2603618, LY2606368",0.869666231504994,0.274088367704952,FALSE +"H358","Pearson.est","cyclooxygenase inhibitor",-0.30426,-0.736,0.8,944,0.934,"indoprofen, FK.3311, curcumin, tepoxalin, piroxicam, aspirin, pterostilbene, naproxen, FR.122047, tryptanthrin",0.0969100130080564,0.0296531237699066,FALSE +"H358","Pearson.est","cytochrome P450 inhibitor",0.40963,1.2,0.232,237,0.694,"PF.4981517, morin, eplerenone, metyrapone",0.6345120151091,0.158640529545145,FALSE +"H358","Pearson.est","DNA alkylating agent",-0.32362,-0.788,0.745,807,0.914,"streptozotocin, carboplatin, temozolomide, ifosfamide, carmustine, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.127843727251707,0.0390538042661686,FALSE +"H358","Pearson.est","DNA inhibitor",-0.35823,-0.876,0.637,841,0.867,"oxaliplatin, carboplatin, valrubicin, carmustine, metronidazole, tirapazamine, pibenzimol, melphalan, mechlorethamine, primaquine",0.19586056766465,0.0619809025237897,FALSE +"H358","Pearson.est","DNA methyltransferase inhibitor",-0.38425,-0.924,0.575,1031,0.836,"fdcyd, RG108, disulfiram",0.24033215531037,0.0777937225609836,FALSE +"H358","Pearson.est","DNA polymerase inhibitor",0.29583,0.844,0.591,1022,0.733,"cephalomannine, menadione, famciclovir, adefovir.dipivoxil, idoxuridine, foscarnet, trifluridine, cidofovir",0.228412519118745,0.134896025358872,FALSE +"H358","Pearson.est","DNA synthesis inhibitor",-0.30582,-0.744,0.793,769,0.941,"cyclocytidine, altretamine, azodicarbonamide, artesunate, anisomycin, estramustine.phosphate, CB.10.277, enocitabine, mitomycin.c",0.100726812682396,0.0264103765727431,FALSE +"H358","Pearson.est","dopamine receptor antagonist",-0.4414,-1.07,0.376,1171,0.768,"paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.424812155072339,0.114638779968488,FALSE +"H358","Pearson.est","estrogen receptor agonist",0.45019,1.33,0.156,176,0.53,"PPT, levonorgestrel, ethinyl.estradiol",0.806875401645538,0.275724130399211,FALSE +"H358","Pearson.est","estrogen receptor antagonist",-0.65727,-1.61,0.0324,1267,0.899,"toremifene, danazol, fulvestrant",1.48945498979339,0.0462403082667712,FALSE +"H358","Pearson.est","FGFR inhibitor",-0.57921,-1.38,0.109,1133,0.465,"PD.173074, MK.2461, lenvatinib, erdafitinib, lucitanib",0.962573502059376,0.332547047110046,FALSE +"H358","Pearson.est","FLT3 inhibitor",-0.60871,-1.46,0.073,1039,0.509,"TG.02, sunitinib, pacritinib, tandutinib, KW.2449, ENMD.2076, ponatinib, TG.101348, GTP.14564, sorafenib, quizartinib, tozasertib",1.13667713987954,0.293282217663241,FALSE +"H358","Pearson.est","glucocorticoid receptor agonist",0.31466,0.864,0.587,319,0.742,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, fluocinolone.acetonide, ciclesonide, halcinonide, prednisolone, fludroxycortide, triamcinolone.acetonide",0.231361898752386,0.129596094720973,FALSE +"H358","Pearson.est","glutamate receptor antagonist",0.31039,0.914,0.553,282,0.746,"SIB.1757, latrepirdine, kynurenic.acid, CGP.37849, JNJ.16259685, CPP",0.257274868695302,0.127261172527331,FALSE +"H358","Pearson.est","glycogen synthase kinase inhibitor",-0.55259,-1.35,0.131,1213,0.507,"GSK.3.inhibitor.IX, LY2090314, kenpaullone, CHIR.98014, indirubin",0.882728704344236,0.294992040666664,FALSE +"H358","Pearson.est","growth factor receptor inhibitor",-0.51515,-1.25,0.205,880,0.527,"GSK1904529A, lestaurtinib, AZD3463, GSK1838705A, GW.441756",0.688246138944246,0.278189384787453,FALSE +"H358","Pearson.est","HCV inhibitor",0.23781,0.693,0.877,69,0.927,"daclatasvir",0.0570004066339595,0.0329202658555029,FALSE +"H358","Pearson.est","HDAC inhibitor",-0.5445,-1.33,0.134,1045,0.496,"entinostat, PCI.24781, dacinostat, panobinostat, scriptaid, AR.42, trichostatin.a, vorinostat, givinostat, RG2833, resminostat, M.344, R306465, RGFP966",0.872895201635192,0.304518323509803,FALSE +"H358","Pearson.est","histamine receptor antagonist",-0.24304,-0.602,0.899,987,0.97,"cyproheptadine, tecastemizole, BF2.649, lafutidine, epinastine",0.0462403082667712,0.0132282657337552,FALSE +"H358","Pearson.est","HMGCR inhibitor",-0.22758,-0.557,0.958,979,0.951,"fluvastatin, lovastatin",0.0186344909214556,0.0218194830625861,FALSE +"H358","Pearson.est","HSP inhibitor",0.4815,1.42,0.114,286,0.471,"BIIB021, KW.2478, SNX.2112, SNX.5422, alvespimycin, NVP.AUY922, ganetespib, VER.49009",0.943095148663527,0.326979092871104,FALSE +"H358","Pearson.est","JAK inhibitor",-0.4049,-0.975,0.487,975,0.862,"lestaurtinib, LY2784544, AZD1480, TG.02, pacritinib, TG.101348, AT.9283, TG.101209, tozasertib",0.312471038785366,0.0644927341752872,FALSE +"H358","Pearson.est","KIT inhibitor",-0.42799,-1.02,0.453,1198,0.808,"lenvatinib, tandutinib, imatinib, sorafenib, KI.8751, masitinib",0.343901797987168,0.0925886392254138,FALSE +"H358","Pearson.est","MDM inhibitor",-0.52506,-1.28,0.184,1164,0.529,"serdemetan, RITA",0.735182176990464,0.276544327964814,FALSE +"H358","Pearson.est","MEK inhibitor",0.62941,1.78,0.0455,201,0.306,"selumetinib, trametinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, cobimetinib, TAK.733, AZD8330, PD.198306, PD.0325901",1.34198860334289,0.51427857351842,FALSE +"H358","Pearson.est","MET inhibitor",-0.59719,-1.44,0.0822,1401,0.463,"NVP.BVU972, AMG458",1.08512818245995,0.334419008982047,FALSE +"H358","Pearson.est","microtubule inhibitor",-0.23995,-0.585,0.938,1334,0.966,"D.64131",0.0277971616209356,0.0150228735845067,FALSE +"H358","Pearson.est","mTOR inhibitor",-0.44583,-1.08,0.374,757,0.77,"GDC.0980, NVP.BEZ235, PF.05212384, AZD8055, OSI.027, voxtalisib, PKI.179, WYE.125132, torin.2, sirolimus, MLN0128, LY303511, XL388, torin.1, LY3023414, PF.04691502, GSK2126458, ku.0063794, WYE.354, SB.2343, AZD2014",0.42712839779952,0.113509274827518,FALSE +"H358","Pearson.est","NFkB pathway inhibitor",-0.39847,-0.973,0.502,1369,0.843,"EVP4593, betulinic.acid",0.299296282854981,0.0741724253752577,FALSE +"H358","Pearson.est","opioid receptor agonist",-0.30186,-0.733,0.804,879,0.92,"salvinorin.a, trimebutine, cebranopadol",0.0947439512515487,0.0362121726544447,FALSE +"H358","Pearson.est","p38 MAPK inhibitor",-0.50835,-1.22,0.242,1365,0.545,"SB.239063, skepinone.l",0.616184634019569,0.263603497723358,FALSE +"H358","Pearson.est","PARP inhibitor",-0.63077,-1.54,0.036,1183,0.572,"AG.14361, PJ.34, E7449, niraparib",1.44369749923271,0.242603971206976,FALSE +"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.46008,-1.11,0.322,1056,0.724,"sunitinib, linifanib, axitinib, crenolanib, lenvatinib, tandutinib, ponatinib, imatinib, sorafenib, KI.8751, masitinib",0.492144128304169,0.140261433802853,FALSE +"H358","Pearson.est","phosphatase inhibitor",-0.41656,-1.01,0.455,680,0.808,"mycophenolic.acid, bis.maltolato.oxovanadium.IV., sodium.stibogluconate, AS.1949490, BVT.948, CID.5458317, alexidine, GSK2830371",0.341988603342888,0.0925886392254138,FALSE +"H358","Pearson.est","phosphodiesterase inhibitor",0.34145,0.993,0.429,957,0.757,"cilostamide, EMD.53998, anagrelide, enoximone, avanafil, papaverine, zardaverine, trequinsin, GSK256066, YM.976",0.367542707815276,0.120904120499927,FALSE +"H358","Pearson.est","PI3K inhibitor",-0.38477,-0.932,0.548,874,0.841,"voxtalisib, PKI.179, BGT226, YM.201636, AZD6482, PI3K.IN.2, TG.100713, LY303511, LY3023414, PF.04691502, GDC.0941, GSK2126458, CUDC.907, SB.2343, CH5132799",0.261219441515631,0.0752040042020878,FALSE +"H358","Pearson.est","PLK inhibitor",-0.31659,-0.76,0.771,720,0.937,"NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.112945621949043,0.0282604091122217,FALSE +"H358","Pearson.est","potassium channel blocker",0.38121,1.1,0.313,132,0.745,"dofetilide, mepivacaine",0.504455662453552,0.127843727251707,FALSE +"H358","Pearson.est","PPAR receptor agonist",-0.35137,-0.852,0.645,897,0.889,"GW.501516, pterostilbene",0.190440285364732,0.0510982390297863,FALSE +"H358","Pearson.est","progesterone receptor agonist",-0.3603,-0.881,0.631,1338,0.878,"melengestrol.acetate, danazol",0.199970640755866,0.0565054840938974,FALSE +"H358","Pearson.est","proteasome inhibitor",0.34431,0.991,0.462,113,0.701,"MG.132, carfilzomib",0.335358024443874,0.154281982033341,FALSE +"H358","Pearson.est","protein synthesis inhibitor",-0.25952,-0.635,0.902,1371,0.959,"florfenicol, azomycin..2.nitroimidazole.",0.0447934624580583,0.0181813928293364,FALSE +"H358","Pearson.est","protein tyrosine kinase inhibitor",-0.38935,-0.936,0.544,1078,0.855,"NVP.TAE226, mubritinib, BMS.599626",0.26440110030182,0.0680338852718274,FALSE +"H358","Pearson.est","RAF inhibitor",-0.29224,-0.708,0.841,1337,0.917,"sorafenib, TAK.632",0.0752040042020878,0.0376306643299789,FALSE +"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.30192,-0.726,0.794,1056,0.912,"sunitinib, cabozantinib, sorafenib",0.100179497572904,0.0400051616715838,FALSE +"H358","Pearson.est","retinoid receptor agonist",-0.65106,-1.59,0.0345,1312,0.686,"adapalene, fenretinide, bexarotene",1.46218090492673,0.163675884293248,FALSE +"H358","Pearson.est","ribonucleotide reductase inhibitor",-0.34825,-0.845,0.66,838,0.881,"clofarabine, cytarabine, fludarabine, cladribine, pentostatin",0.180456064458131,0.0550240915879521,FALSE +"H358","Pearson.est","serotonin receptor agonist",-0.58377,-1.42,0.0883,1225,0.472,"ipsapirone, aripiprazole",1.05403929642243,0.326058001365912,FALSE +"H358","Pearson.est","serotonin receptor antagonist",-0.50702,-1.23,0.219,1374,0.544,"lurasidone, aripiprazole",0.659555885159882,0.26440110030182,FALSE +"H358","Pearson.est","sodium channel blocker",-0.42192,-1.03,0.437,1237,0.811,"triamterene, quinidine, ajmaline, lappaconite",0.359518563029578,0.090979145788844,FALSE +"H358","Pearson.est","src inhibitor",0.37597,1.07,0.338,20,0.668,"dasatinib, saracatinib",0.471083299722345,0.175223537524454,FALSE +"H358","Pearson.est","sterol demethylase inhibitor",-0.58877,-1.4,0.0922,1047,0.451,"terconazole, ketoconazole",1.03526907894637,0.345823458122039,FALSE +"H358","Pearson.est","TGF beta receptor inhibitor",-0.31905,-0.79,0.74,1359,0.93,"adaprev",0.130768280269024,0.0315170514460649,FALSE +"H358","Pearson.est","thymidylate synthase inhibitor",0.37308,1.08,0.316,232,0.711,"capecitabine, doxifluridine, ftorafur",0.500312917381596,0.148130399270234,FALSE +"H358","Pearson.est","topoisomerase inhibitor",-0.36856,-0.901,0.571,873,0.859,"topotecan, valrubicin, camptothecin, nemorubicin, etoposide.phosphate, voreloxin, fleroxacin, rubitecan, SN.38, TAS.103, dexrazoxane, genz.644282, irinotecan",0.243363891754152,0.0660068361687577,FALSE +"H358","Pearson.est","tubulin polymerization inhibitor",0.14547,0.411,1,5,0.998,"mebendazole",0,0.000869458712628891,FALSE +"H358","Pearson.est","tyrosine kinase inhibitor",-0.28411,-0.688,0.874,1056,0.923,"sunitinib, cabozantinib, NVP.TAE226, mubritinib, BMS.599626, GTP.14564, sorafenib, UNC2250",0.058488567365597,0.0347982989740879,FALSE +"H358","Pearson.est","VEGFR inhibitor",-0.33972,-0.823,0.706,1056,0.898,"sunitinib, cabozantinib, linifanib, RAF265, axitinib, PD.173074, MK.2461, lenvatinib, ENMD.2076, tivozanib, MGCD.265, sorafenib, lucitanib, KI.8751",0.151195298948196,0.0467236633326956,FALSE +"H358","Pearson.est","vitamin D receptor agonist",-0.57068,-1.4,0.0943,1279,0.451,"maxacalcitol, paricalcitol, tacalcitol",1.02548830726267,0.345823458122039,FALSE +"H1650","Pearson.est","EGFR inhibitor",0.42459,1.2,0.237,225,0.51,"pelitinib, canertinib, afatinib, XL.647, vandetanib, brigatinib, BMS.690514, rociletinib, erlotinib, CUDC.101, dacomitinib, AZD8931, neratinib, lapatinib, poziotinib, PD.168393, AEE788",0.625251653989896,0.292429823902064,FALSE +"H1650","Pearson.est","Abl kinase inhibitor",-0.5425,-1.33,0.149,1063,0.62,"metatinib, KW.2449, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.826813731587726,0.207608310501746,FALSE +"H1650","Pearson.est","acetylcholine receptor agonist",-0.45659,-1.12,0.331,1151,0.624,"nicotine, nefiracetam, pilocarpine",0.480172006224281,0.204815410317576,FALSE +"H1650","Pearson.est","acetylcholine receptor antagonist",-0.5,-1.21,0.235,721,0.677,"hyoscyamine, darifenacin, diphemanil, dicycloverine, iododexetimide, methscopolamine",0.628932137728264,0.169411331314856,FALSE +"H1650","Pearson.est","adenosine receptor antagonist",-0.54559,-1.33,0.149,901,0.62,"sulmazole, CGS.15943, istradefylline, MRS.1220, SCH.58261",0.826813731587726,0.207608310501746,FALSE +"H1650","Pearson.est","adrenergic receptor agonist",-0.40619,-0.99,0.508,750,0.74,"midodrine, metaraminol, xylazine, methyldopa, ritodrine, A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.294136287716081,0.130768280269024,FALSE +"H1650","Pearson.est","adrenergic receptor antagonist",0.43388,1.21,0.23,276,0.604,"prazosin, vincamine, RS.17053, practolol, levobunolol, dihydroergocristine, imiloxan, idazoxan, atenolol....",0.638272163982407,0.218963061378868,FALSE +"H1650","Pearson.est","AKT inhibitor",-0.39566,-0.967,0.487,1116,0.763,"ONC201, uprosertib, A.674563, CCT128930",0.312471038785366,0.11747546204512,FALSE +"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.30112,-0.73,0.829,1213,0.892,"AP26113, alectinib, DMH1",0.0814454694497265,0.0496351456238769,FALSE +"H1650","Pearson.est","androgen receptor antagonist",-0.54233,-1.31,0.158,992,0.637,"nilutamide, flutamide, bicalutamide",0.801342913045577,0.19586056766465,FALSE +"H1650","Pearson.est","antioxidant",-0.48184,-1.15,0.286,1322,0.675,"benfotiamine, trolox",0.543633966870957,0.170696227168975,FALSE +"H1650","Pearson.est","AP inhibitor",0.54764,1.55,0.0945,60,0.86,"birinapant, GDC.0152",1.02456819149074,0.0655015487564323,FALSE +"H1650","Pearson.est","ATPase inhibitor",0.23444,0.65,0.908,282,1,"k.strophanthidin, digitoxin, blebbistatin...., ouabain",0.0419141514789149,0,FALSE +"H1650","Pearson.est","Aurora kinase inhibitor",-0.55976,-1.37,0.123,1076,0.805,"AMG900, SNS.314, KW.2449, CCT129202, AT.9283, aurora.a.inhibitor.i, MK.8745, PF.03814735, barasertib, ENMD.2076, hesperadin, tozasertib",0.910094888560602,0.0942041196321315,FALSE +"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.49327,-1.22,0.216,1035,0.685,"josamycin, tilmicosin, radezolid, dirithromycin",0.665546248849069,0.164309428507574,FALSE +"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.47315,1.33,0.144,184,0.62,"novobiocin, finafloxacin, sarafloxacin",0.84163750790475,0.207608310501746,FALSE +"H1650","Pearson.est","BCL inhibitor",-0.41492,-1.01,0.452,1031,0.721,"gossypol, ABT.737",0.344861565188618,0.142064735280571,FALSE +"H1650","Pearson.est","Bcr.Abl kinase inhibitor",-0.54162,-1.3,0.167,1063,0.622,"metatinib, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.777283528852417,0.206209615309181,FALSE +"H1650","Pearson.est","benzodiazepine receptor agonist",0.22733,0.649,0.9,74,0.964,"ZK.93423, gamma.aminobutyric.acid",0.0457574905606751,0.0159229660971692,FALSE +"H1650","Pearson.est","bromodomain inhibitor",-0.46154,-1.13,0.317,932,0.625,"JQ1...., PFI.1, bromosporine, I.BET151",0.498940737782249,0.204119982655925,FALSE +"H1650","Pearson.est","calcium channel blocker",-0.55487,-1.35,0.13,1218,0.722,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",0.886056647693163,0.141462802430361,FALSE +"H1650","Pearson.est","CC chemokine receptor antagonist",-0.46291,-1.13,0.326,754,0.625,"UNBS.5162, MK.0812, RS.504393, SB.225002, PF.04136309, navarixin",0.486782399932061,0.204119982655925,FALSE +"H1650","Pearson.est","CDK inhibitor",-0.30902,-0.754,0.771,1089,0.893,"abemaciclib, ribociclib, kenpaullone, NU6027, R547, indirubin, arcyriaflavin.a",0.112945621949043,0.0491485411114536,FALSE +"H1650","Pearson.est","CHK inhibitor",0.52087,1.48,0.0664,92,0.555,"SCH.900776, CHIR.124, LY2603618",1.17783192063198,0.255707016877324,FALSE +"H1650","Pearson.est","cyclooxygenase inhibitor",-0.29618,-0.707,0.831,1003,0.887,"tepoxalin, piroxicam, FK.3311, metoxibutropate, indoprofen, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.080398976215889,0.0520763801682736,FALSE +"H1650","Pearson.est","cytochrome P450 inhibitor",0.22317,0.632,0.924,296,0.902,"PF.4981517, morin, eplerenone",0.0343280287798933,0.0447934624580583,FALSE +"H1650","Pearson.est","DNA alkylating agent",-0.38774,-0.939,0.55,1047,0.776,"carmustine, temozolomide, cyclophosphamide, carboplatin, melphalan, satraplatin, mitomycin.c",0.259637310505756,0.110138278741812,FALSE +"H1650","Pearson.est","DNA inhibitor",-0.44238,-1.08,0.372,1047,0.628,"carmustine, pibenzimol, primaquine, carboplatin, melphalan, tirapazamine, metronidazole, mechlorethamine",0.429457060118102,0.202040356262804,FALSE +"H1650","Pearson.est","DNA methyltransferase inhibitor",0.33916,0.933,0.5,228,0.867,"decitabine, SGI.1027, azacitidine",0.301029995663981,0.0619809025237897,FALSE +"H1650","Pearson.est","DNA polymerase inhibitor",0.30903,0.869,0.651,1003,0.836,"cephalomannine, menadione, famciclovir, adefovir.dipivoxil, idoxuridine, trifluridine, cidofovir, foscarnet",0.186419011431808,0.0777937225609836,FALSE +"H1650","Pearson.est","DNA synthesis inhibitor",-0.35591,-0.872,0.615,793,0.802,"cisplatin, nelarabine, azodicarbonamide, artesunate, estramustine.phosphate, enocitabine, altretamine, CB.10.277, mitomycin.c",0.211124884224583,0.0958256317158365,FALSE +"H1650","Pearson.est","dopamine receptor antagonist",-0.42633,-1.05,0.428,747,0.664,"clebopride, oxiperomide, ziprasidone, raclopride, domperidone, amisulpride, paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.368556230986828,0.177831920631982,FALSE +"H1650","Pearson.est","estrogen receptor agonist",0.4752,1.34,0.152,30,0.719,"PPT, levonorgestrel",0.818156412055227,0.143271109617117,FALSE +"H1650","Pearson.est","estrogen receptor antagonist",-0.74426,-1.8,0.0069,1268,0.396,"toremifene, fulvestrant, danazol",2.16115090926274,0.402304814074488,FALSE +"H1650","Pearson.est","FGFR inhibitor",-0.61889,-1.49,0.0519,1037,0.77,"orantinib, PD.173074, lucitanib, lenvatinib, MK.2461, erdafitinib",1.28483264215154,0.113509274827518,FALSE +"H1650","Pearson.est","FLT3 inhibitor",-0.63389,-1.51,0.0547,1096,0.857,"midostaurin, KW.2449, sunitinib, sorafenib, TG.101348, tandutinib, GTP.14564, ENMD.2076, quizartinib, ponatinib, tozasertib",1.26201267366657,0.0670191780768018,FALSE +"H1650","Pearson.est","glucocorticoid receptor agonist",0.45273,1.26,0.183,279,0.578,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, prednisolone, triamcinolone.acetonide, fluocinolone.acetonide, fludroxycortide, halcinonide, desonide",0.737548910269571,0.238072161579471,FALSE +"H1650","Pearson.est","glutamate receptor antagonist",0.25111,0.707,0.813,100,0.98,"SIB.1757, latrepirdine",0.0899094544059319,0.00877392430750515,FALSE +"H1650","Pearson.est","glycogen synthase kinase inhibitor",-0.54843,-1.33,0.15,1202,0.62,"kenpaullone, LY2090314, GSK.3.inhibitor.IX, indirubin, CHIR.98014",0.823908740944319,0.207608310501746,FALSE +"H1650","Pearson.est","growth factor receptor inhibitor",-0.51855,-1.26,0.187,774,0.652,"GSK1904529A, AZD3463, lestaurtinib, GSK1838705A, GW.441756",0.728158393463501,0.18575240426808,FALSE +"H1650","Pearson.est","HCV inhibitor",-0.36197,-0.874,0.602,1305,0.817,"narlaprevir",0.220403508742175,0.0877779434675845,FALSE +"H1650","Pearson.est","HDAC inhibitor",-0.4644,-1.14,0.313,1126,0.673,"AR.42, panobinostat, givinostat, trichostatin.a, vorinostat, resminostat, M.344, RG2833, R306465, RGFP966",0.504455662453552,0.171984935776023,FALSE +"H1650","Pearson.est","histamine receptor antagonist",-0.37707,-0.92,0.569,1198,0.792,"BF2.649, lafutidine, tecastemizole, epinastine",0.244887733604929,0.101274818410506,FALSE +"H1650","Pearson.est","HMGCR inhibitor",-0.55585,-1.36,0.115,1285,0.758,"lovastatin, fluvastatin",0.939302159646388,0.120330794367946,FALSE +"H1650","Pearson.est","HSP inhibitor",0.55286,1.52,0.0785,293,0.643,"BIIB021, KW.2478, alvespimycin, SNX.5422, SNX.2112, NVP.AUY922, VER.49009, ganetespib",1.10513034325475,0.191789027075778,FALSE +"H1650","Pearson.est","JAK inhibitor",-0.33795,-0.812,0.705,864,0.883,"WHI.P154, LY2784544, lestaurtinib, CEP.33779, AT.9283, AZD1480, TG.101348, TG.101209, tozasertib",0.151810883008601,0.0540392964224314,FALSE +"H1650","Pearson.est","KIT inhibitor",-0.49765,-1.2,0.248,1096,0.671,"midostaurin, sunitinib, sorafenib, imatinib, tandutinib, lenvatinib, KI.8751, masitinib",0.605548319173784,0.173277479831008,FALSE +"H1650","Pearson.est","MDM inhibitor",-0.4558,-1.11,0.371,1352,0.624,"RITA",0.430626090384954,0.204815410317576,FALSE +"H1650","Pearson.est","MEK inhibitor",0.67269,1.87,0.0123,176,0.477,"trametinib, selumetinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, cobimetinib, AZD8330, TAK.733, PD.198306, PD.0325901",1.9100948885606,0.321481620959886,FALSE +"H1650","Pearson.est","MET inhibitor",-0.6643,-1.61,0.0301,1411,0.899,"NVP.BVU972, AMG458",1.52143350440616,0.0462403082667712,FALSE +"H1650","Pearson.est","microtubule inhibitor",0.22462,0.636,0.919,1125,0.936,"secnidazole, triclabendazole, vinflunine, podophyllotoxin, vinblastine, cytochalasin.b, cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.0366844886138887,0.0287241512618947,FALSE +"H1650","Pearson.est","mTOR inhibitor",-0.45002,-1.08,0.373,810,0.628,"temsirolimus, deforolimus, NVP.BEZ235, PKI.179, torin.2, OSI.027, voxtalisib, MLN0128, LY303511, sirolimus, XL388, GSK2126458, PF.04691502, torin.1, ku.0063794, LY3023414, WYE.354, AZD2014, SB.2343",0.428291168191312,0.202040356262804,FALSE +"H1650","Pearson.est","NFkB pathway inhibitor",-0.30137,-0.727,0.805,812,0.879,"parthenolide, curcumin, bortezomib, bindarit, EVP4593, betulinic.acid",0.0942041196321315,0.0560111249262281,FALSE +"H1650","Pearson.est","opioid receptor agonist",-0.50057,-1.22,0.241,876,0.685,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.617982957425132,0.164309428507574,FALSE +"H1650","Pearson.est","p38 MAPK inhibitor",-0.51628,-1.27,0.2,1004,0.663,"SB.242235, TAK.715, SB.239063, skepinone.l",0.698970004336019,0.178486471595227,FALSE +"H1650","Pearson.est","PARP inhibitor",-0.60004,-1.48,0.0695,1163,0.681,"AG.14361, niraparib, PJ.34, E7449",1.15801519540989,0.166852888087215,FALSE +"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49183,-1.19,0.259,1037,0.637,"orantinib, crenolanib, sunitinib, axitinib, sorafenib, linifanib, imatinib, tandutinib, lenvatinib, ponatinib, KI.8751, masitinib",0.586700235918748,0.19586056766465,FALSE +"H1650","Pearson.est","phosphatase inhibitor",-0.47754,-1.16,0.295,928,0.679,"sodium.stibogluconate, bis.maltolato.oxovanadium.IV., CID.5458317, alexidine, GSK2830371, BVT.948",0.530177984021837,0.168130225719498,FALSE +"H1650","Pearson.est","phosphodiesterase inhibitor",0.24965,0.713,0.789,1089,1,"cilostamide, EMD.53998, enoximone, avanafil, anagrelide, papaverine, trequinsin, zardaverine, YM.976, GSK256066",0.10292299679058,0,FALSE +"H1650","Pearson.est","PI3K inhibitor",-0.39275,-0.956,0.504,781,0.764,"pilaralisib, PI.828, NVP.BEZ235, PI3K.IN.2, PKI.179, TG.100713, voxtalisib, TG100.115, BGT226, LY303511, AZD6482, GSK2126458, CUDC.907, PF.04691502, LY3023414, GDC.0941, CH5132799, SB.2343",0.297569463554475,0.11690664142431,FALSE +"H1650","Pearson.est","PLK inhibitor",0.30673,0.874,0.573,1006,0.878,"HMN.214, GSK461364, BI.2536, NMS.1286937, volasertib, rigosertib, GW.843682X",0.24184537803261,0.0565054840938974,FALSE +"H1650","Pearson.est","potassium channel blocker",-0.23605,-0.57,0.941,947,0.978,"ML133, ibutilide, meglitinide",0.0264103765727431,0.00966114521239857,FALSE +"H1650","Pearson.est","PPAR receptor agonist",-0.37035,-0.903,0.584,1291,0.804,"pterostilbene",0.233587152887601,0.0947439512515487,FALSE +"H1650","Pearson.est","progesterone receptor agonist",-0.32688,-0.803,0.735,1288,0.861,"melengestrol.acetate, danazol",0.133712660915805,0.0649968485463452,FALSE +"H1650","Pearson.est","proteasome inhibitor",0.43607,1.2,0.237,85,0.51,"MG.132, carfilzomib",0.625251653989896,0.292429823902064,FALSE +"H1650","Pearson.est","protein synthesis inhibitor",0.37826,1.04,0.399,107,0.759,"homoharringtonine, bruceantin, cycloheximide, anguidine, chloramphenicol.palmitate, clofoctol",0.399027104313252,0.11975822410452,FALSE +"H1650","Pearson.est","protein tyrosine kinase inhibitor",-0.28628,-0.705,0.828,1087,0.873,"mubritinib, BMS.599626",0.0819696632151199,0.0589857562944303,FALSE +"H1650","Pearson.est","RAF inhibitor",0.28005,0.775,0.775,101,0.968,"AZ.628, vemurafenib, LGX818",0.11069829749369,0.0141246426916063,FALSE +"H1650","Pearson.est","RET tyrosine kinase inhibitor",-0.31141,-0.757,0.761,910,0.907,"apatinib, cabozantinib, sunitinib, sorafenib",0.118615343229427,0.0423927129399047,FALSE +"H1650","Pearson.est","retinoid receptor agonist",-0.48763,-1.19,0.252,1215,0.637,"fenretinide, adapalene, bexarotene",0.598599459218456,0.19586056766465,FALSE +"H1650","Pearson.est","ribonucleotide reductase inhibitor",-0.31274,-0.749,0.775,803,0.883,"fludarabine, clofarabine, hydroxyurea, cytarabine, cladribine, pentostatin",0.11069829749369,0.0540392964224314,FALSE +"H1650","Pearson.est","serotonin receptor agonist",-0.56616,-1.39,0.121,1316,0.938,"ipsapirone, aripiprazole",0.91721462968355,0.0277971616209356,FALSE +"H1650","Pearson.est","serotonin receptor antagonist",-0.46722,-1.13,0.32,1351,0.625,"lurasidone, aripiprazole",0.494850021680094,0.204119982655925,FALSE +"H1650","Pearson.est","sodium channel blocker",-0.45897,-1.1,0.347,993,0.626,"cibenzoline, A.803467, oxcarbazepine, ajmaline, triamterene, quinidine, lappaconite",0.459670525209126,0.20342566678957,FALSE +"H1650","Pearson.est","src inhibitor",0.3346,0.932,0.489,22,0.811,"saracatinib, dasatinib",0.31069114087638,0.090979145788844,FALSE +"H1650","Pearson.est","sterol demethylase inhibitor",-0.61916,-1.52,0.0553,1185,1,"terconazole, ketoconazole",1.2572748686953,0,FALSE +"H1650","Pearson.est","TGF beta receptor inhibitor",-0.36906,-0.895,0.576,1384,0.8,"adaprev",0.239577516576788,0.0969100130080564,FALSE +"H1650","Pearson.est","thymidylate synthase inhibitor",0.46542,1.3,0.143,99,0.587,"capecitabine, doxifluridine",0.844663962534938,0.231361898752386,FALSE +"H1650","Pearson.est","topoisomerase inhibitor",-0.22291,-0.549,0.946,787,0.973,"topotecan, voreloxin, camptothecin, valrubicin, nemorubicin, etoposide.phosphate, rubitecan, SN.38, TAS.103, genz.644282, dexrazoxane, fleroxacin, irinotecan",0.0241088635982073,0.0118871597316481,FALSE +"H1650","Pearson.est","tubulin polymerization inhibitor",0.35078,0.982,0.46,364,0.824,"mebendazole, CYT.997, paclitaxel, BNC105, vincristine, vindesine, taltobulin, epothilone.b, vinorelbine, oxibendazole, fosbretabulin, verubulin, dolastatin.10, fenbendazole",0.337242168318426,0.0840727883028842,FALSE +"H1650","Pearson.est","tyrosine kinase inhibitor",-0.21991,-0.533,0.966,1070,0.965,"cabozantinib, mubritinib, sunitinib, sorafenib, BMS.599626, GTP.14564, UNC2250",0.0150228735845067,0.0154726866562074,FALSE +"H1650","Pearson.est","VEGFR inhibitor",-0.33358,-0.81,0.702,1037,0.868,"orantinib, RAF265, cabozantinib, sunitinib, PD.173074, axitinib, sorafenib, linifanib, lucitanib, lenvatinib, MK.2461, ENMD.2076, MGCD.265, tivozanib, KI.8751",0.153662887870195,0.0614802748235081,FALSE +"H1650","Pearson.est","vitamin D receptor agonist",-0.55625,-1.38,0.107,1183,0.86,"maxacalcitol, paricalcitol, tacalcitol",0.97061622231479,0.0655015487564323,FALSE +"HCC95","Pearson.est","EGFR inhibitor",0.40029,1.11,0.281,187,0.674,"canertinib, pelitinib, BMS.690514, brigatinib, erlotinib, vandetanib, XL.647, afatinib, rociletinib, CUDC.101, AZD8931, neratinib, dacomitinib, PD.168393, lapatinib",0.55129368009492,0.17134010346468,FALSE +"HCC95","Pearson.est","Abl kinase inhibitor",-0.55118,-1.34,0.149,1052,0.6,"metatinib, flumatinib, nilotinib, KW.2449, imatinib, ponatinib, tozasertib",0.826813731587726,0.221848749616356,FALSE +"HCC95","Pearson.est","acetylcholine receptor agonist",-0.47506,-1.18,0.265,1181,0.548,"nicotine, nefiracetam, pilocarpine",0.576754126063192,0.261219441515631,FALSE +"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.57666,-1.41,0.0978,1071,0.862,"dicycloverine, iododexetimide, methscopolamine",1.0096611452124,0.0644927341752872,FALSE +"HCC95","Pearson.est","adenosine receptor antagonist",-0.50479,-1.23,0.232,976,0.53,"istradefylline, CGS.15943, MRS.1220, SCH.58261",0.6345120151091,0.275724130399211,FALSE +"HCC95","Pearson.est","adrenergic receptor agonist",-0.48151,-1.18,0.272,1123,0.548,"A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.565431095965801,0.261219441515631,FALSE +"HCC95","Pearson.est","adrenergic receptor antagonist",0.45575,1.3,0.149,257,0.584,"prazosin, vincamine, RS.17053, practolol, levobunolol, imiloxan, dihydroergocristine, atenolol...., idazoxan",0.826813731587726,0.233587152887601,FALSE +"HCC95","Pearson.est","AKT inhibitor",-0.50086,-1.21,0.254,1225,0.548,"ONC201, uprosertib, A.674563, CCT128930",0.595166283380062,0.261219441515631,FALSE +"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.26846,-0.654,0.887,1204,0.925,"alectinib, AP26113, DMH1",0.0520763801682736,0.0338582672609674,FALSE +"HCC95","Pearson.est","androgen receptor antagonist",-0.57143,-1.4,0.107,1002,0.708,"nilutamide, flutamide, bicalutamide",0.97061622231479,0.149966742310231,FALSE +"HCC95","Pearson.est","antioxidant",-0.49417,-1.18,0.283,1328,0.548,"benfotiamine, trolox",0.54821356447571,0.261219441515631,FALSE +"HCC95","Pearson.est","AP inhibitor",0.55424,1.59,0.052,53,0.794,"birinapant, GDC.0152",1.2839966563652,0.100179497572904,FALSE +"HCC95","Pearson.est","ATPase inhibitor",0.27405,0.781,0.7,232,0.952,"k.strophanthidin, ouabain, digitoxin, blebbistatin....",0.154901959985743,0.0213630516155257,FALSE +"HCC95","Pearson.est","Aurora kinase inhibitor",-0.58542,-1.43,0.11,1077,0.902,"barasertib.HQPA, CCT129202, AT.9283, aurora.a.inhibitor.i, AMG900, SNS.314, KW.2449, MK.8745, PF.03814735, ENMD.2076, barasertib, hesperadin, tozasertib",0.958607314841775,0.0447934624580583,FALSE +"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.53302,-1.29,0.173,806,0.581,"valnemulin, azithromycin, azalomycin.b, josamycin, tilmicosin, radezolid, dirithromycin",0.761953896871205,0.235823867609669,FALSE +"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.50667,1.4,0.138,133,0.747,"finafloxacin, sarafloxacin, novobiocin",0.860120913598763,0.126679398184601,FALSE +"HCC95","Pearson.est","BCL inhibitor",-0.51576,-1.24,0.216,1199,0.606,"gossypol, ABT.737",0.665546248849069,0.217527375833714,FALSE +"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.53868,-1.33,0.163,1052,0.549,"metatinib, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.787812395596042,0.260427655549908,FALSE +"HCC95","Pearson.est","benzodiazepine receptor agonist",0.26377,0.753,0.746,50,0.903,"ZK.93423, gamma.aminobutyric.acid",0.127261172527331,0.0443122496864942,FALSE +"HCC95","Pearson.est","bromodomain inhibitor",-0.56203,-1.35,0.132,1065,0.668,"JQ1...., PFI.1, I.BET151, bromosporine",0.87942606879415,0.175223537524454,FALSE +"HCC95","Pearson.est","calcium channel blocker",-0.54724,-1.33,0.14,1209,0.549,"cinnarazine, mibefradil, carboxyamidotriazole, SR.33805",0.853871964321762,0.260427655549908,FALSE +"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.36195,-0.884,0.612,737,0.837,"RS.504393, MK.0812, SB.225002, PF.04136309, navarixin",0.213248577854439,0.07727454200674,FALSE +"HCC95","Pearson.est","CDK inhibitor",-0.39096,-0.953,0.513,942,0.754,"AZD5438, palbociclib, BMS.265246, JNJ.7706621, indisulam, ribociclib, kenpaullone, abemaciclib, NU6027, R547, indirubin, arcyriaflavin.a",0.289882634888184,0.122628654130226,FALSE +"HCC95","Pearson.est","CHK inhibitor",0.47175,1.31,0.148,149,0.657,"SCH.900776, CHIR.124, LY2603618",0.829738284605043,0.182434630440219,FALSE +"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.29145,-0.71,0.824,910,0.898,"meloxicam, curcumin, naproxen, metoxibutropate, piroxicam, aspirin, FK.3311, indoprofen, tepoxalin, pterostilbene, FR.122047, tryptanthrin",0.0840727883028842,0.0467236633326956,FALSE +"HCC95","Pearson.est","cytochrome P450 inhibitor",0.23857,0.657,0.864,353,0.908,"PF.4981517, morin, eplerenone, metyrapone",0.0634862575211067,0.0419141514789149,FALSE +"HCC95","Pearson.est","DNA alkylating agent",-0.40624,-0.989,0.471,895,0.742,"temozolomide, ifosfamide, streptozotocin, carboplatin, carmustine, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.326979092871104,0.129596094720973,FALSE +"HCC95","Pearson.est","DNA inhibitor",-0.45822,-1.11,0.351,1035,0.623,"carboplatin, tirapazamine, carmustine, primaquine, metronidazole, pibenzimol, melphalan, mechlorethamine",0.454692883534176,0.20551195334083,FALSE +"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.35786,-0.868,0.644,1271,0.826,"RG108, disulfiram",0.191114132640188,0.0830199526796178,FALSE +"HCC95","Pearson.est","DNA polymerase inhibitor",0.30069,0.834,0.59,1015,1,"cephalomannine, famciclovir, menadione, adefovir.dipivoxil, idoxuridine, trifluridine, cidofovir, foscarnet",0.229147988357856,0,FALSE +"HCC95","Pearson.est","DNA synthesis inhibitor",-0.33834,-0.825,0.69,758,0.806,"anisomycin, nelarabine, cisplatin, artesunate, azodicarbonamide, estramustine.phosphate, CB.10.277, altretamine, enocitabine, mitomycin.c",0.161150909262745,0.0936649581949093,FALSE +"HCC95","Pearson.est","dopamine receptor antagonist",-0.42318,-1.03,0.431,985,0.743,"raclopride, amisulpride, UH.232...., paliperidone, nemonapride, lurasidone, mesoridazine",0.365522729839268,0.129011186239425,FALSE +"HCC95","Pearson.est","estrogen receptor agonist",0.44615,1.24,0.211,33,0.621,"levonorgestrel, PPT",0.675717544702307,0.20690839982342,FALSE +"HCC95","Pearson.est","estrogen receptor antagonist",-0.69692,-1.69,0.0219,1244,0.53,"toremifene, fulvestrant, danazol",1.65955588515988,0.275724130399211,FALSE +"HCC95","Pearson.est","FGFR inhibitor",-0.58217,-1.4,0.0938,1022,0.708,"orantinib, PD.173074, lenvatinib, MK.2461, erdafitinib, lucitanib",1.02779716162094,0.149966742310231,FALSE +"HCC95","Pearson.est","FLT3 inhibitor",-0.63292,-1.54,0.0456,1101,0.992,"midostaurin, tandutinib, sunitinib, TG.101348, KW.2449, GTP.14564, sorafenib, ENMD.2076, quizartinib, ponatinib, tozasertib",1.34103515733556,0.00348832784582135,FALSE +"HCC95","Pearson.est","glucocorticoid receptor agonist",0.48436,1.36,0.115,271,0.679,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, prednisolone, halcinonide, fluocinolone.acetonide, triamcinolone.acetonide, desonide, fludroxycortide",0.939302159646388,0.168130225719498,FALSE +"HCC95","Pearson.est","glutamate receptor antagonist",0.29559,0.824,0.69,61,0.978,"SIB.1757, latrepirdine",0.161150909262745,0.00966114521239857,FALSE +"HCC95","Pearson.est","glycogen synthase kinase inhibitor",-0.50413,-1.23,0.225,1150,0.53,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, CHIR.98014, indirubin",0.647817481888638,0.275724130399211,FALSE +"HCC95","Pearson.est","growth factor receptor inhibitor",-0.51633,-1.23,0.235,786,0.53,"GSK1904529A, lestaurtinib, AZD3463, GSK1838705A, GW.441756",0.628932137728264,0.275724130399211,FALSE +"HCC95","Pearson.est","HCV inhibitor",0.29728,0.82,0.69,64,0.931,"daclatasvir",0.161150909262745,0.0310503190186574,FALSE +"HCC95","Pearson.est","HDAC inhibitor",-0.55162,-1.34,0.152,1075,0.6,"PCI.24781, entinostat, dacinostat, AR.42, panobinostat, vorinostat, trichostatin.a, givinostat, M.344, RG2833, R306465, resminostat, RGFP966",0.818156412055227,0.221848749616356,FALSE +"HCC95","Pearson.est","histamine receptor antagonist",-0.35967,-0.878,0.625,1183,0.828,"BF2.649, tecastemizole, lafutidine, epinastine",0.204119982655925,0.0819696632151199,FALSE +"HCC95","Pearson.est","HMGCR inhibitor",-0.40853,-0.989,0.486,1145,0.742,"fluvastatin, lovastatin",0.313363730737707,0.129596094720973,FALSE +"HCC95","Pearson.est","HSP inhibitor",0.53932,1.46,0.106,311,0.809,"BIIB021, KW.2478, alvespimycin, SNX.5422, SNX.2112, VER.49009, NVP.AUY922",0.97469413473523,0.0920514783877277,FALSE +"HCC95","Pearson.est","JAK inhibitor",-0.31264,-0.758,0.769,867,0.871,"lestaurtinib, pacritinib, CEP.33779, LY2784544, AZD1480, AT.9283, TG.101348, TG.101209, tozasertib",0.114073660198569,0.0599818449923368,FALSE +"HCC95","Pearson.est","KIT inhibitor",-0.52729,-1.27,0.196,1061,0.596,"telatinib, midostaurin, tandutinib, sunitinib, sorafenib, lenvatinib, imatinib, KI.8751, masitinib",0.707743928643524,0.224753740259764,FALSE +"HCC95","Pearson.est","MDM inhibitor",-0.34788,-0.839,0.666,1092,0.818,"serdemetan, RITA",0.176525770829699,0.087246696328677,FALSE +"HCC95","Pearson.est","MEK inhibitor",0.68065,1.93,0.0112,127,0.363,"trametinib, selumetinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, AZD8330, cobimetinib, TAK.733, PD.198306, PD.0325901",1.95078197732982,0.440093374963888,FALSE +"HCC95","Pearson.est","MET inhibitor",-0.77155,-1.88,0,1424,0.18,"NVP.BVU972, AMG458",Inf,0.744727494896694,TRUE +"HCC95","Pearson.est","microtubule inhibitor",-0.1864,-0.451,0.989,1073,0.991,"estramustine.phosphate, D.64131",0.0048037084028206,0.00392634551472468,FALSE +"HCC95","Pearson.est","mTOR inhibitor",-0.41782,-1.03,0.422,800,0.743,"temsirolimus, PKI.179, voxtalisib, NVP.BEZ235, OSI.027, torin.2, MLN0128, LY303511, sirolimus, XL388, GSK2126458, LY3023414, PF.04691502, torin.1, ku.0063794, AZD2014, WYE.354, SB.2343",0.374687549038326,0.129011186239425,FALSE +"HCC95","Pearson.est","NFkB pathway inhibitor",-0.28526,-0.703,0.836,834,0.89,"bindarit, parthenolide, bortezomib, curcumin, EVP4593, betulinic.acid",0.0777937225609836,0.0506099933550872,FALSE +"HCC95","Pearson.est","opioid receptor agonist",-0.4795,-1.16,0.294,925,0.547,"salvinorin.a, ADL5859, trimebutine, cebranopadol",0.531652669587843,0.262012673666569,FALSE +"HCC95","Pearson.est","p38 MAPK inhibitor",-0.40585,-0.977,0.466,1280,0.746,"SB.239063, skepinone.l",0.33161408331,0.127261172527331,FALSE +"HCC95","Pearson.est","PARP inhibitor",-0.56347,-1.38,0.127,1104,0.699,"AG.14361, niraparib, PJ.34, E7449",0.896196279044043,0.155522824254319,FALSE +"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.5222,-1.26,0.183,1022,0.588,"orantinib, telatinib, crenolanib, tandutinib, sunitinib, linifanib, axitinib, sorafenib, lenvatinib, imatinib, ponatinib, KI.8751, masitinib",0.737548910269571,0.230622673923862,FALSE +"HCC95","Pearson.est","phosphatase inhibitor",-0.47928,-1.17,0.247,843,0.547,"AS.1949490, sodium.stibogluconate, bis.maltolato.oxovanadium.IV., CID.5458317, alexidine, GSK2830371, BVT.948",0.607303046740334,0.262012673666569,FALSE +"HCC95","Pearson.est","phosphodiesterase inhibitor",0.20472,0.581,0.934,171,0.94,"cilostamide, EMD.53998",0.0296531237699066,0.0268721464003014,FALSE +"HCC95","Pearson.est","PI3K inhibitor",-0.41224,-0.989,0.481,803,0.742,"PKI.179, YM.201636, voxtalisib, NVP.BEZ235, pilaralisib, AZD6482, TG.100713, TG100.115, BGT226, PI3K.IN.2, LY303511, GSK2126458, LY3023414, PF.04691502, GDC.0941, CUDC.907, CH5132799, SB.2343",0.317854923626168,0.129596094720973,FALSE +"HCC95","Pearson.est","PLK inhibitor",0.27134,0.765,0.722,1057,0.93,"HMN.214, NMS.1286937, GSK461364, BI.2536, volasertib, rigosertib, GW.843682X",0.141462802430361,0.0315170514460649,FALSE +"HCC95","Pearson.est","potassium channel blocker",0.25413,0.705,0.808,290,0.886,"dofetilide, oleoylethanolamide, mepivacaine",0.0925886392254138,0.0525662781129492,FALSE +"HCC95","Pearson.est","PPAR receptor agonist",-0.3419,-0.834,0.666,1286,0.809,"pterostilbene",0.176525770829699,0.0920514783877277,FALSE +"HCC95","Pearson.est","progesterone receptor agonist",-0.34019,-0.84,0.664,1288,0.834,"melengestrol.acetate, danazol",0.177831920631982,0.0788339493622613,FALSE +"HCC95","Pearson.est","proteasome inhibitor",0.40558,1.11,0.303,112,0.674,"MG.132, carfilzomib",0.518557371497695,0.17134010346468,FALSE +"HCC95","Pearson.est","protein synthesis inhibitor",0.31632,0.878,0.592,301,0.993,"clofoctol, cycloheximide, homoharringtonine, bruceantin, chloramphenicol.palmitate, anguidine, methacycline, puromycin, harringtonine",0.22767829327708,0.00305075150461883,FALSE +"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.29791,-0.715,0.828,691,0.909,"tyrphostin.A9, PP.121, rheochrysidin, NVP.TAE226, mubritinib, BMS.599626",0.0819696632151199,0.0414361167780325,FALSE +"HCC95","Pearson.est","RAF inhibitor",0.26731,0.742,0.744,99,0.876,"vemurafenib, AZ.628, LGX818",0.128427064454121,0.0574958938319193,FALSE +"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.41429,-1.02,0.453,1154,0.743,"sunitinib, cabozantinib, sorafenib",0.343901797987168,0.129011186239425,FALSE +"HCC95","Pearson.est","retinoid receptor agonist",-0.59462,-1.44,0.0933,1320,1,"adapalene, bexarotene, fenretinide",1.0301183562535,0,FALSE +"HCC95","Pearson.est","ribonucleotide reductase inhibitor",-0.32701,-0.81,0.699,877,0.812,"hydroxyurea, clofarabine, fludarabine, cladribine, pentostatin",0.155522824254319,0.0904439707588247,FALSE +"HCC95","Pearson.est","serotonin receptor agonist",-0.60681,-1.48,0.0774,1001,1,"zolmitriptan, NAN.190, ipsapirone, aripiprazole",1.11125903931711,0,FALSE +"HCC95","Pearson.est","serotonin receptor antagonist",-0.50267,-1.23,0.248,1178,0.53,"paliperidone, lurasidone, aripiprazole",0.605548319173784,0.275724130399211,FALSE +"HCC95","Pearson.est","sodium channel blocker",-0.39499,-0.968,0.505,1226,0.745,"ajmaline, quinidine, triamterene, lappaconite",0.296708621881339,0.127843727251707,FALSE +"HCC95","Pearson.est","src inhibitor",-0.34836,-0.847,0.644,1142,0.841,"KX2.391, PP.1, masitinib",0.191114132640188,0.0752040042020878,FALSE +"HCC95","Pearson.est","sterol demethylase inhibitor",-0.55363,-1.36,0.127,1162,0.698,"terconazole, ketoconazole",0.896196279044043,0.156144577376839,FALSE +"HCC95","Pearson.est","TGF beta receptor inhibitor",0.39919,1.1,0.319,92,0.638,"repsox, SB.525334",0.496209316942819,0.195179321278838,FALSE +"HCC95","Pearson.est","thymidylate synthase inhibitor",0.43664,1.19,0.249,135,0.649,"capecitabine, doxifluridine",0.603800652904264,0.187755303199631,FALSE +"HCC95","Pearson.est","topoisomerase inhibitor",-0.25514,-0.617,0.911,858,0.942,"topotecan, valrubicin, camptothecin, etoposide.phosphate, nemorubicin, SN.38, TAS.103, rubitecan, genz.644282, dexrazoxane, fleroxacin, irinotecan",0.0404816230270017,0.0259490972071227,FALSE +"HCC95","Pearson.est","tubulin polymerization inhibitor",0.30916,0.889,0.554,270,1,"mebendazole, CYT.997, vincristine, paclitaxel, BNC105, vindesine, oxibendazole, epothilone.b",0.25649023527157,0,FALSE +"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.22179,-0.531,0.954,1140,0.982,"BMS.599626, sunitinib, cabozantinib, GTP.14564, sorafenib, UNC2250",0.0204516252959049,0.00788851221305034,FALSE +"HCC95","Pearson.est","VEGFR inhibitor",-0.37564,-0.898,0.588,1022,0.83,"orantinib, RAF265, telatinib, PD.173074, sunitinib, cabozantinib, linifanib, axitinib, sorafenib, ENMD.2076, lenvatinib, MK.2461, lucitanib, tivozanib, MGCD.265, KI.8751",0.230622673923862,0.0809219076239261,FALSE +"HCC95","Pearson.est","vitamin D receptor agonist",-0.54349,-1.32,0.15,1191,0.539,"maxacalcitol, paricalcitol, tacalcitol",0.823908740944319,0.268411234813261,FALSE +"H3255","Pearson.est","EGFR inhibitor",0.49584,1.37,0.141,241,0.593,"canertinib, pelitinib, BMS.690514, XL.647, afatinib, erlotinib, rociletinib, vandetanib, brigatinib, AZD8931, CUDC.101, dacomitinib, lapatinib, neratinib, poziotinib, PD.168393, gefitinib, AEE788, osimertinib",0.85078088734462,0.226945306635737,FALSE +"H3255","Pearson.est","Abl kinase inhibitor",-0.46955,-1.18,0.255,1090,0.617,"KW.2449, nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.593459819566045,0.209714835966758,FALSE +"H3255","Pearson.est","acetylcholine receptor agonist",-0.51262,-1.24,0.224,1223,0.776,"nefiracetam, nicotine, pilocarpine",0.649751981665837,0.110138278741812,FALSE +"H3255","Pearson.est","acetylcholine receptor antagonist",-0.62081,-1.53,0.0552,1175,0.524,"dicycloverine, methscopolamine, iododexetimide",1.2580609222708,0.280668713016273,FALSE +"H3255","Pearson.est","adenosine receptor antagonist",-0.42874,-1.02,0.459,760,0.757,"CGS.15943, sulmazole, istradefylline, MRS.1220, SCH.58261",0.338187314462739,0.120904120499927,FALSE +"H3255","Pearson.est","adrenergic receptor agonist",-0.47998,-1.17,0.283,1207,0.591,"isoxsuprine, A61603, isoetharine, buphenine, norepinephrine",0.54821356447571,0.228412519118745,FALSE +"H3255","Pearson.est","adrenergic receptor antagonist",0.40234,1.14,0.291,277,0.493,"prazosin, vincamine, RS.17053, practolol, dihydroergocristine, levobunolol, idazoxan, imiloxan",0.536107011014093,0.30715308072277,FALSE +"H3255","Pearson.est","AKT inhibitor",-0.36232,-0.877,0.615,1045,0.834,"uprosertib, ONC201, A.674563, CCT128930",0.211124884224583,0.0788339493622613,FALSE +"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.31672,-0.775,0.756,1240,0.847,"alectinib, AP26113, DMH1",0.121478204498793,0.0721165896692931,FALSE +"H3255","Pearson.est","androgen receptor antagonist",-0.63481,-1.55,0.0564,1125,0.697,"nilutamide, flutamide, bicalutamide",1.24872089601666,0.156767221901991,FALSE +"H3255","Pearson.est","antioxidant",-0.55511,-1.36,0.144,1352,0.683,"benfotiamine, trolox",0.84163750790475,0.165579296318467,FALSE +"H3255","Pearson.est","AP inhibitor",0.5637,1.59,0.0726,59,0.542,"birinapant, GDC.0152",1.13906337929991,0.266000713461613,FALSE +"H3255","Pearson.est","ATPase inhibitor",0.26377,0.702,0.774,7,1,"k.strophanthidin",0.111259039317107,0,FALSE +"H3255","Pearson.est","Aurora kinase inhibitor",-0.51031,-1.24,0.207,1004,0.776,"barasertib.HQPA, AMG900, aurora.a.inhibitor.i, CCT129202, AT.9283, SNS.314, KW.2449, MK.8745, ENMD.2076, PF.03814735, barasertib, hesperadin, tozasertib",0.684029654543082,0.110138278741812,FALSE +"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.59929,-1.45,0.086,973,0.609,"azithromycin, azalomycin.b, josamycin, radezolid, tilmicosin, dirithromycin",1.06550154875643,0.215382707367125,FALSE +"H3255","Pearson.est","bacterial DNA gyrase inhibitor",0.48365,1.31,0.165,170,0.622,"finafloxacin, novobiocin, sarafloxacin",0.782516055786094,0.206209615309181,FALSE +"H3255","Pearson.est","BCL inhibitor",-0.34925,-0.848,0.644,1135,0.806,"gossypol, ABT.737",0.191114132640188,0.0936649581949093,FALSE +"H3255","Pearson.est","Bcr.Abl kinase inhibitor",-0.53686,-1.32,0.165,1182,0.748,"nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.782516055786094,0.126098402135539,FALSE +"H3255","Pearson.est","benzodiazepine receptor agonist",0.21783,0.609,0.938,96,1,"ZK.93423, gamma.aminobutyric.acid",0.0277971616209356,0,FALSE +"H3255","Pearson.est","bromodomain inhibitor",-0.43252,-1.04,0.412,871,0.765,"JQ1...., PFI.1, I.BET151, bromosporine",0.385102783966865,0.116338564846382,FALSE +"H3255","Pearson.est","calcium channel blocker",-0.49267,-1.21,0.241,1173,0.73,"cinnarazine, mibefradil, carboxyamidotriazole, SR.33805",0.617982957425132,0.136677139879544,FALSE +"H3255","Pearson.est","CC chemokine receptor antagonist",-0.36157,-0.878,0.614,1170,0.874,"PF.04136309, navarixin",0.211831628858832,0.058488567365597,FALSE +"H3255","Pearson.est","CDK inhibitor",-0.28386,-0.689,0.84,900,0.888,"BMS.265246, indisulam, AZD5438, JNJ.7706621, kenpaullone, ribociclib, abemaciclib, NU6027, R547, arcyriaflavin.a, indirubin",0.0757207139381184,0.051587034221399,FALSE +"H3255","Pearson.est","CHK inhibitor",0.5472,1.52,0.0931,89,0.538,"SCH.900776, CHIR.124, LY2603618",1.03105031901866,0.269217724333611,FALSE +"H3255","Pearson.est","cyclooxygenase inhibitor",-0.29365,-0.71,0.822,1022,0.882,"aspirin, FK.3311, tepoxalin, piroxicam, metoxibutropate, indoprofen, naproxen, pterostilbene, FR.122047, tryptanthrin",0.0851281824599496,0.0545314148681803,FALSE +"H3255","Pearson.est","cytochrome P450 inhibitor",-0.25583,-0.61,0.909,1337,0.948,"clotrimazole",0.0414361167780325,0.0231916626619338,FALSE +"H3255","Pearson.est","DNA alkylating agent",-0.4127,-1.01,0.444,1075,0.754,"temozolomide, cyclophosphamide, carmustine, carboplatin, melphalan, satraplatin, mitomycin.c",0.35261702988538,0.122628654130226,FALSE +"H3255","Pearson.est","DNA inhibitor",-0.42267,-1.02,0.44,1113,0.757,"pibenzimol, carmustine, carboplatin, metronidazole, melphalan, tirapazamine, mechlorethamine",0.356547323513813,0.120904120499927,FALSE +"H3255","Pearson.est","DNA methyltransferase inhibitor",0.42506,1.19,0.219,198,0.581,"decitabine, SGI.1027, azacitidine",0.659555885159882,0.235823867609669,FALSE +"H3255","Pearson.est","DNA polymerase inhibitor",0.34743,0.991,0.4,64,0.667,"cephalomannine",0.397940008672038,0.175874166083451,FALSE +"H3255","Pearson.est","DNA synthesis inhibitor",-0.3372,-0.836,0.676,972,0.808,"nelarabine, estramustine.phosphate, enocitabine, CB.10.277, altretamine, mitomycin.c",0.170053304058364,0.0925886392254138,FALSE +"H3255","Pearson.est","dopamine receptor antagonist",-0.40525,-0.979,0.463,1088,0.774,"amisulpride, paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.334419008982047,0.111259039317107,FALSE +"H3255","Pearson.est","estrogen receptor agonist",0.43425,1.2,0.229,43,0.617,"PPT, levonorgestrel",0.640164517660112,0.209714835966758,FALSE +"H3255","Pearson.est","estrogen receptor antagonist",-0.76628,-1.88,0.00855,1336,0.202,"toremifene, fulvestrant, danazol",2.06803388527183,0.694648630553376,TRUE +"H3255","Pearson.est","FGFR inhibitor",-0.63245,-1.54,0.0438,1039,0.593,"orantinib, PD.173074, lenvatinib, MK.2461, lucitanib, erdafitinib",1.3585258894959,0.226945306635737,FALSE +"H3255","Pearson.est","FLT3 inhibitor",-0.63194,-1.5,0.0722,1084,0.534,"sunitinib, KW.2449, sorafenib, ENMD.2076, midostaurin, GTP.14564, tandutinib, TG.101348, quizartinib, ponatinib, tozasertib",1.14146280243036,0.272458742971444,FALSE +"H3255","Pearson.est","glucocorticoid receptor agonist",0.43726,1.17,0.274,272,0.566,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, prednisolone, triamcinolone.acetonide, halcinonide, desonide, fluocinolone.acetonide",0.562249437179612,0.247183568811729,FALSE +"H3255","Pearson.est","glutamate receptor antagonist",0.23694,0.667,0.827,110,1,"SIB.1757, latrepirdine",0.0824944904474534,0,FALSE +"H3255","Pearson.est","glycogen synthase kinase inhibitor",-0.5166,-1.27,0.181,1246,0.851,"GSK.3.inhibitor.IX, LY2090314, indirubin, CHIR.98014",0.742321425130815,0.0700704399154121,FALSE +"H3255","Pearson.est","growth factor receptor inhibitor",-0.49056,-1.2,0.228,782,0.684,"AZD3463, lestaurtinib, GSK1904529A, GSK1838705A, GW.441756",0.642065152999546,0.164943898279884,FALSE +"H3255","Pearson.est","HCV inhibitor",0.38666,1.06,0.375,53,0.587,"daclatasvir",0.425968732272281,0.231361898752386,FALSE +"H3255","Pearson.est","HDAC inhibitor",-0.4784,-1.17,0.3,1063,0.591,"AR.42, panobinostat, trichostatin.a, givinostat, vorinostat, M.344, RG2833, resminostat, R306465, RGFP966",0.522878745280338,0.228412519118745,FALSE +"H3255","Pearson.est","histamine receptor antagonist",-0.29622,-0.71,0.834,1142,0.882,"BF2.649, tecastemizole, lafutidine, epinastine",0.0788339493622613,0.0545314148681803,FALSE +"H3255","Pearson.est","HMGCR inhibitor",-0.64843,-1.56,0.0427,983,0.872,"mevastatin, atorvastatin, lovastatin, fluvastatin",1.36957212497498,0.0594835150674328,FALSE +"H3255","Pearson.est","HSP inhibitor",0.62413,1.69,0.0356,280,0.574,"BIIB021, KW.2478, alvespimycin, SNX.5422, SNX.2112, NVP.AUY922, VER.49009, ganetespib",1.44855000202712,0.241088107602027,FALSE +"H3255","Pearson.est","JAK inhibitor",-0.35901,-0.877,0.632,1067,0.834,"AZD1480, AT.9283, CEP.33779, TG.101348, TG.101209, tozasertib",0.199282921717615,0.0788339493622613,FALSE +"H3255","Pearson.est","KIT inhibitor",-0.49898,-1.19,0.271,1084,0.646,"sunitinib, sorafenib, imatinib, midostaurin, tandutinib, lenvatinib, KI.8751, masitinib",0.567030709125594,0.189767482004916,FALSE +"H3255","Pearson.est","MDM inhibitor",-0.36796,-0.913,0.557,1083,0.854,"serdemetan, RITA",0.254144804826271,0.068542129310995,FALSE +"H3255","Pearson.est","MEK inhibitor",0.6913,1.87,0.027,132,0.506,"trametinib, selumetinib, AS.703026, Ro.4987655, AZD8330, MEK1.2.inhibitor, cobimetinib, TAK.733, PD.0325901, PD.198306",1.56863623584101,0.295849483160201,FALSE +"H3255","Pearson.est","MET inhibitor",-0.70389,-1.72,0.0157,1413,0.415,"NVP.BVU972, AMG458",1.80410034759077,0.381951903287907,FALSE +"H3255","Pearson.est","microtubule inhibitor",0.20723,0.582,0.925,1150,1,"triclabendazole, secnidazole, vinflunine, podophyllotoxin, vinblastine, cytochalasin.b, cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.0338582672609674,0,FALSE +"H3255","Pearson.est","mTOR inhibitor",-0.3858,-0.927,0.575,969,0.851,"XL388, sirolimus, GSK2126458, LY303511, torin.1, LY3023414, PF.04691502, AZD2014, ku.0063794, WYE.354, SB.2343",0.24033215531037,0.0700704399154121,FALSE +"H3255","Pearson.est","NFkB pathway inhibitor",-0.21609,-0.526,0.969,762,0.966,"BAY.11.7085, bortezomib, bindarit, curcumin, parthenolide, EVP4593, betulinic.acid",0.0136762229492347,0.0150228735845067,FALSE +"H3255","Pearson.est","opioid receptor agonist",-0.45999,-1.14,0.301,771,0.628,"BW.180C, ADL5859, salvinorin.a, trimebutine, cebranopadol",0.521433504406157,0.202040356262804,FALSE +"H3255","Pearson.est","p38 MAPK inhibitor",-0.48778,-1.18,0.253,1157,0.617,"TAK.715, SB.239063, skepinone.l",0.596879478824182,0.209714835966758,FALSE +"H3255","Pearson.est","PARP inhibitor",-0.58771,-1.44,0.0958,1158,0.57,"AG.14361, niraparib, PJ.34, E7449",1.01863449092146,0.244125144327509,FALSE +"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.48509,-1.19,0.275,1039,0.646,"orantinib, sunitinib, crenolanib, sorafenib, axitinib, linifanib, imatinib, tandutinib, lenvatinib, ponatinib, KI.8751, masitinib",0.560667306169737,0.189767482004916,FALSE +"H3255","Pearson.est","phosphatase inhibitor",-0.46127,-1.13,0.302,870,0.626,"AS.1949490, CID.5458317, sodium.stibogluconate, bis.maltolato.oxovanadium.IV., alexidine, GSK2830371, BVT.948",0.519993057042849,0.20342566678957,FALSE +"H3255","Pearson.est","phosphodiesterase inhibitor",0.19301,0.563,0.951,189,0.99,"cilostamide, EMD.53998",0.0218194830625861,0.00436480540245009,FALSE +"H3255","Pearson.est","PI3K inhibitor",-0.36507,-0.892,0.59,774,0.871,"voxtalisib, PI.828, TG.100713, PI3K.IN.2, YM.201636, BGT226, pilaralisib, TG100.115, GSK2126458, LY303511, AZD6482, LY3023414, CUDC.907, PF.04691502, GDC.0941, CH5132799, SB.2343",0.229147988357856,0.0599818449923368,FALSE +"H3255","Pearson.est","PLK inhibitor",0.32933,0.905,0.539,95,0.744,"HMN.214",0.268411234813261,0.128427064454121,FALSE +"H3255","Pearson.est","potassium channel blocker",-0.35444,-0.87,0.625,1181,0.826,"ibutilide, meglitinide",0.204119982655925,0.0830199526796178,FALSE +"H3255","Pearson.est","PPAR receptor agonist",-0.35309,-0.858,0.637,1286,0.827,"pterostilbene",0.19586056766465,0.0824944904474534,FALSE +"H3255","Pearson.est","progesterone receptor agonist",-0.41991,-1.05,0.399,1169,0.769,"dienogest, melengestrol.acetate, danazol",0.399027104313252,0.114073660198569,FALSE +"H3255","Pearson.est","proteasome inhibitor",0.45494,1.26,0.188,94,0.565,"carfilzomib, MG.132",0.72584215073632,0.247951552180562,FALSE +"H3255","Pearson.est","protein synthesis inhibitor",0.42804,1.26,0.171,305,0.565,"homoharringtonine, bruceantin, cycloheximide, anguidine, clofoctol, chloramphenicol.palmitate, harringtonine, methacycline, puromycin, emetine",0.767003889607846,0.247951552180562,FALSE +"H3255","Pearson.est","protein tyrosine kinase inhibitor",0.28681,0.789,0.722,1035,0.913,"AV.412, tyrphostin.A9, CP.724714, PP.121, mubritinib, NVP.TAE226, rheochrysidin, BMS.599626",0.141462802430361,0.039529222465701,FALSE +"H3255","Pearson.est","RAF inhibitor",0.32205,0.906,0.576,121,0.783,"AZ.628, LGX818, vemurafenib",0.239577516576788,0.106238237942057,FALSE +"H3255","Pearson.est","RET tyrosine kinase inhibitor",-0.32491,-0.793,0.722,1084,0.839,"sunitinib, sorafenib, cabozantinib",0.141462802430361,0.0762380391712997,FALSE +"H3255","Pearson.est","retinoid receptor agonist",-0.52257,-1.26,0.2,1247,0.822,"fenretinide, adapalene, bexarotene",0.698970004336019,0.0851281824599496,FALSE +"H3255","Pearson.est","ribonucleotide reductase inhibitor",-0.33086,-0.809,0.686,845,0.832,"cytarabine, hydroxyurea, clofarabine, fludarabine, cladribine, pentostatin",0.163675884293248,0.0798766737092761,FALSE +"H3255","Pearson.est","serotonin receptor agonist",-0.57527,-1.38,0.122,1117,0.684,"NAN.190, ipsapirone, aripiprazole",0.913640169325252,0.164943898279884,FALSE +"H3255","Pearson.est","serotonin receptor antagonist",-0.49694,-1.22,0.236,1323,0.788,"lurasidone, aripiprazole",0.627087997029893,0.103473782510445,FALSE +"H3255","Pearson.est","sodium channel blocker",-0.40308,-0.984,0.473,960,0.785,"cibenzoline, A.803467, ajmaline, oxcarbazepine, triamterene, quinidine, lappaconite",0.325138859262188,0.105130343254747,FALSE +"H3255","Pearson.est","src inhibitor",-0.34356,-0.85,0.654,1146,0.821,"KX2.391, PP.1, masitinib",0.184422251675733,0.0856568428805592,FALSE +"H3255","Pearson.est","sterol demethylase inhibitor",-0.49964,-1.21,0.23,1159,0.73,"terconazole, ketoconazole",0.638272163982407,0.136677139879544,FALSE +"H3255","Pearson.est","TGF beta receptor inhibitor",0.41881,1.15,0.264,104,0.514,"repsox, SB.525334",0.578396073130169,0.289036881004724,FALSE +"H3255","Pearson.est","thymidylate synthase inhibitor",0.52417,1.47,0.122,319,0.512,"capecitabine, doxifluridine, ftorafur, carmofur",0.913640169325252,0.290730039024169,FALSE +"H3255","Pearson.est","topoisomerase inhibitor",-0.21691,-0.532,0.967,859,0.981,"camptothecin, voreloxin, topotecan, nemorubicin, SN.38, etoposide.phosphate, TAS.103, rubitecan, genz.644282, dexrazoxane, fleroxacin, irinotecan",0.0145735259169983,0.0083309926200515,FALSE +"H3255","Pearson.est","tubulin polymerization inhibitor",0.4244,1.15,0.256,367,0.514,"mebendazole, paclitaxel, CYT.997, BNC105, vindesine, vincristine, epothilone.b, taltobulin, oxibendazole, dolastatin.10, vinorelbine, podophyllotoxin, fenbendazole, fosbretabulin",0.59176003468815,0.289036881004724,FALSE +"H3255","Pearson.est","tyrosine kinase inhibitor",0.16647,0.468,0.993,175,0.991,"vandetanib, dasatinib, hypericin, AV.412",0.00305075150461883,0.00392634551472468,FALSE +"H3255","Pearson.est","VEGFR inhibitor",-0.29843,-0.74,0.796,1084,0.878,"sunitinib, sorafenib, cabozantinib, axitinib, PD.173074, linifanib, ENMD.2076, lenvatinib, MK.2461, lucitanib, tivozanib, MGCD.265, KI.8751",0.0990869322623309,0.0565054840938974,FALSE +"H3255","Pearson.est","vitamin D receptor agonist",-0.49027,-1.2,0.234,1111,0.684,"maxacalcitol, paricalcitol, tacalcitol",0.630784142589857,0.164943898279884,FALSE +"H1648","Pearson.est","EGFR inhibitor",0.40956,1.19,0.243,186,0.815,"pelitinib, canertinib, brigatinib, vandetanib, XL.647, BMS.690514, afatinib, erlotinib, rociletinib, CUDC.101, dacomitinib, AZD8931, neratinib, PD.168393, lapatinib",0.614393726401688,0.0888423912600234,FALSE +"H1648","Pearson.est","Abl kinase inhibitor",-0.52206,-1.27,0.196,1158,0.67,"KW.2449, nilotinib, imatinib, flumatinib, ponatinib, tozasertib",0.707743928643524,0.173925197299174,FALSE +"H1648","Pearson.est","acetylcholine receptor agonist",-0.40693,-0.987,0.483,1064,0.751,"nicotine, nefiracetam, pilocarpine",0.316052869248488,0.124360062995832,FALSE +"H1648","Pearson.est","acetylcholine receptor antagonist",-0.47575,-1.16,0.291,1056,0.643,"dicycloverine, iododexetimide, methscopolamine",0.536107011014093,0.191789027075778,FALSE +"H1648","Pearson.est","adenosine receptor antagonist",-0.57482,-1.38,0.13,1027,0.598,"CGS.15943, istradefylline, MRS.1220, SCH.58261",0.886056647693163,0.223298816011589,FALSE +"H1648","Pearson.est","adrenergic receptor agonist",-0.48498,-1.17,0.279,1099,0.647,"A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.554395796726402,0.1890957193313,FALSE +"H1648","Pearson.est","adrenergic receptor antagonist",0.38544,1.1,0.321,230,0.866,"prazosin, vincamine, RS.17053, practolol, levobunolol, dihydroergocristine, idazoxan",0.493494967595128,0.0624821079826534,FALSE +"H1648","Pearson.est","AKT inhibitor",-0.40502,-0.974,0.503,1095,0.755,"ONC201, uprosertib, A.674563, CCT128930",0.298432014944073,0.122053048370812,FALSE +"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.2471,0.686,0.841,143,1,"brigatinib, GW.788388, lorlatinib",0.0752040042020878,0,FALSE +"H1648","Pearson.est","androgen receptor antagonist",-0.61496,-1.48,0.0595,1032,0.774,"nilutamide, flutamide, bicalutamide",1.22548303427145,0.111259039317107,FALSE +"H1648","Pearson.est","antioxidant",-0.49244,-1.19,0.251,1323,0.63,"benfotiamine, trolox",0.600326278518962,0.200659450546418,FALSE +"H1648","Pearson.est","AP inhibitor",0.54387,1.5,0.0897,50,0.58,"GDC.0152, birinapant",1.04720755695591,0.236572006437063,FALSE +"H1648","Pearson.est","ATPase inhibitor",0.26585,0.744,0.781,198,1,"k.strophanthidin, digitoxin, ouabain",0.1073489661227,0,FALSE +"H1648","Pearson.est","Aurora kinase inhibitor",-0.58096,-1.42,0.104,1077,0.671,"barasertib.HQPA, AMG900, CCT129202, aurora.a.inhibitor.i, AT.9283, KW.2449, SNS.314, ENMD.2076, PF.03814735, MK.8745, barasertib, hesperadin, tozasertib",0.98296666070122,0.173277479831008,FALSE +"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.49843,-1.21,0.237,848,0.71,"azithromycin, azalomycin.b, tilmicosin, josamycin, radezolid, dirithromycin",0.625251653989896,0.148741651280925,FALSE +"H1648","Pearson.est","bacterial DNA gyrase inhibitor",0.41798,1.16,0.304,218,0.8,"novobiocin, finafloxacin, sarafloxacin",0.517126416391246,0.0969100130080564,FALSE +"H1648","Pearson.est","BCL inhibitor",-0.39412,-0.957,0.516,1129,0.746,"gossypol, ABT.737",0.287350298372789,0.127261172527331,FALSE +"H1648","Pearson.est","Bcr.Abl kinase inhibitor",-0.51987,-1.26,0.201,1176,0.62,"nilotinib, imatinib, flumatinib, ponatinib, tozasertib",0.696803942579511,0.207608310501746,FALSE +"H1648","Pearson.est","benzodiazepine receptor agonist",0.18389,0.523,0.979,171,1,"ZK.93423, gamma.aminobutyric.acid, eprinomectin",0.00921730819686218,0,FALSE +"H1648","Pearson.est","bromodomain inhibitor",-0.58773,-1.42,0.0857,1050,0.671,"JQ1...., PFI.1, I.BET151, bromosporine",1.0670191780768,0.173277479831008,FALSE +"H1648","Pearson.est","calcium channel blocker",-0.56673,-1.39,0.109,1205,0.625,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",0.962573502059376,0.204119982655925,FALSE +"H1648","Pearson.est","CC chemokine receptor antagonist",-0.45353,-1.1,0.345,817,0.676,"RS.504393, MK.0812, SB.225002, PF.04136309, navarixin",0.462180904926726,0.170053304058364,FALSE +"H1648","Pearson.est","CDK inhibitor",-0.34089,-0.816,0.709,978,0.831,"AZD5438, BMS.265246, abemaciclib, ribociclib, JNJ.7706621, NU6027, kenpaullone, R547, indirubin, arcyriaflavin.a",0.149353764816933,0.080398976215889,FALSE +"H1648","Pearson.est","CHK inhibitor",0.55562,1.59,0.0598,83,0.557,"SCH.900776, CHIR.124, LY2603618",1.22329881601159,0.254144804826271,FALSE +"H1648","Pearson.est","cyclooxygenase inhibitor",-0.3438,-0.844,0.648,1089,0.884,"FK.3311, tepoxalin, indoprofen, piroxicam, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.188424994129407,0.0535477349869269,FALSE +"H1648","Pearson.est","cytochrome P450 inhibitor",-0.20945,-0.514,0.971,1039,0.972,"cobicistat, clotrimazole",0.0127807700919951,0.0123337350737254,FALSE +"H1648","Pearson.est","DNA alkylating agent",-0.40385,-0.963,0.52,1036,0.755,"temozolomide, carmustine, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.283996656365201,0.122053048370812,FALSE +"H1648","Pearson.est","DNA inhibitor",-0.42145,-1.02,0.45,1055,0.729,"carmustine, carboplatin, pibenzimol, melphalan, metronidazole, primaquine, tirapazamine, mechlorethamine",0.346787486224656,0.137272471682025,FALSE +"H1648","Pearson.est","DNA methyltransferase inhibitor",0.36269,1.06,0.369,214,0.811,"decitabine, SGI.1027, azacitidine",0.43297363384094,0.090979145788844,FALSE +"H1648","Pearson.est","DNA polymerase inhibitor",0.35556,0.974,0.462,936,0.881,"cephalomannine, menadione, famciclovir, adefovir.dipivoxil, idoxuridine, trifluridine, foscarnet, cidofovir",0.335358024443874,0.0550240915879521,FALSE +"H1648","Pearson.est","DNA synthesis inhibitor",-0.32137,-0.771,0.756,783,0.859,"cisplatin, nelarabine, azodicarbonamide, artesunate, estramustine.phosphate, altretamine, enocitabine, CB.10.277, mitomycin.c",0.121478204498793,0.0660068361687577,FALSE +"H1648","Pearson.est","dopamine receptor antagonist",-0.40927,-1,0.465,1131,0.747,"paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.332547047110046,0.126679398184601,FALSE +"H1648","Pearson.est","estrogen receptor agonist",0.43086,1.23,0.206,40,0.958,"PPT, levonorgestrel",0.686132779630847,0.0186344909214556,FALSE +"H1648","Pearson.est","estrogen receptor antagonist",-0.71319,-1.73,0.012,1262,0.669,"toremifene, danazol, fulvestrant",1.92081875395238,0.174573882232177,FALSE +"H1648","Pearson.est","FGFR inhibitor",-0.63062,-1.55,0.048,985,0.838,"orantinib, PD.173074, lenvatinib, MK.2461, erdafitinib, lucitanib",1.31875876262441,0.0767559813697235,FALSE +"H1648","Pearson.est","FLT3 inhibitor",-0.56447,-1.37,0.121,1098,0.572,"midostaurin, sorafenib, KW.2449, ENMD.2076, tandutinib, TG.101348, ponatinib, GTP.14564, quizartinib, tozasertib",0.91721462968355,0.242603971206976,FALSE +"H1648","Pearson.est","glucocorticoid receptor agonist",0.37849,1.08,0.343,284,0.834,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, halcinonide, prednisolone, fluocinolone.acetonide, triamcinolone.acetonide, desonide",0.464705879957229,0.0788339493622613,FALSE +"H1648","Pearson.est","glutamate receptor antagonist",-0.23727,-0.574,0.939,1259,0.976,"MTPG, IEM1754",0.0273344077338891,0.0105501823333082,FALSE +"H1648","Pearson.est","glycogen synthase kinase inhibitor",-0.53439,-1.3,0.174,1169,0.672,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, CHIR.98014, indirubin",0.7594507517174,0.172630726946175,FALSE +"H1648","Pearson.est","growth factor receptor inhibitor",-0.48657,-1.2,0.237,896,0.7,"lestaurtinib, GSK1904529A, GSK1838705A, GW.441756",0.625251653989896,0.154901959985743,FALSE +"H1648","Pearson.est","HCV inhibitor",0.29376,0.835,0.656,82,0.962,"daclatasvir",0.18309616062434,0.0168249279621871,FALSE +"H1648","Pearson.est","HDAC inhibitor",-0.5183,-1.26,0.206,1109,0.62,"dacinostat, AR.42, panobinostat, vorinostat, givinostat, trichostatin.a, RG2833, M.344, resminostat, R306465, RGFP966",0.686132779630847,0.207608310501746,FALSE +"H1648","Pearson.est","histamine receptor antagonist",-0.33658,-0.833,0.673,1078,0.881,"cyproheptadine, BF2.649, tecastemizole, lafutidine, epinastine",0.171984935776023,0.0550240915879521,FALSE +"H1648","Pearson.est","HMGCR inhibitor",-0.48895,-1.19,0.263,1238,0.63,"fluvastatin, lovastatin",0.580044251510242,0.200659450546418,FALSE +"H1648","Pearson.est","HSP inhibitor",0.57715,1.63,0.0622,245,0.715,"BIIB021, KW.2478, SNX.5422, alvespimycin, SNX.2112, NVP.AUY922, ganetespib, VER.49009",1.20620961530918,0.145693958198919,FALSE +"H1648","Pearson.est","JAK inhibitor",-0.32192,-0.783,0.741,1157,0.861,"AT.9283, AZD1480, TG.101348, TG.101209, tozasertib",0.130181792020672,0.0649968485463452,FALSE +"H1648","Pearson.est","KIT inhibitor",-0.44088,-1.08,0.358,1098,0.653,"midostaurin, sorafenib, imatinib, tandutinib, lenvatinib, KI.8751, masitinib",0.446116973356126,0.185086818724926,FALSE +"H1648","Pearson.est","MDM inhibitor",-0.44831,-1.1,0.37,1101,0.676,"serdemetan, RITA",0.431798275933005,0.170053304058364,FALSE +"H1648","Pearson.est","MEK inhibitor",0.66901,1.89,0.00833,178,0.475,"selumetinib, trametinib, AS.703026, Ro.4987655, cobimetinib, MEK1.2.inhibitor, AZD8330, TAK.733, PD.198306, PD.0325901",2.07935499859321,0.323306390375133,FALSE +"H1648","Pearson.est","MET inhibitor",-0.70283,-1.72,0.0211,1416,0.362,"NVP.BVU972, AMG458",1.67571754470231,0.441291429466834,FALSE +"H1648","Pearson.est","microtubule inhibitor",0.1669,0.486,0.988,1208,0.987,"secnidazole, triclabendazole, vinflunine, podophyllotoxin, vinblastine, cytochalasin.b, cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.00524305541237188,0.00568284733036327,FALSE +"H1648","Pearson.est","mTOR inhibitor",-0.37835,-0.919,0.565,1006,0.793,"LY303511, sirolimus, GSK2126458, XL388, torin.1, PF.04691502, LY3023414, ku.0063794, AZD2014, WYE.354, SB.2343",0.247951552180562,0.100726812682396,FALSE +"H1648","Pearson.est","NFkB pathway inhibitor",-0.27686,-0.669,0.85,883,0.914,"parthenolide, bindarit, curcumin, EVP4593, betulinic.acid",0.0705810742857073,0.0390538042661686,FALSE +"H1648","Pearson.est","opioid receptor agonist",-0.47589,-1.15,0.297,851,0.64,"ADL5859, trimebutine, salvinorin.a, cebranopadol",0.527243550682788,0.193820026016113,FALSE +"H1648","Pearson.est","p38 MAPK inhibitor",-0.48859,-1.19,0.273,975,0.63,"TAK.715, SB.242235, SB.239063, skepinone.l",0.563837352959244,0.200659450546418,FALSE +"H1648","Pearson.est","PARP inhibitor",-0.59979,-1.47,0.0729,1191,0.683,"AG.14361, niraparib, E7449, PJ.34",1.13727247168203,0.165579296318467,FALSE +"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.45248,-1.08,0.365,985,0.653,"orantinib, sunitinib, crenolanib, sorafenib, axitinib, linifanib, imatinib, tandutinib, lenvatinib, ponatinib, KI.8751, masitinib",0.437707135543525,0.185086818724926,FALSE +"H1648","Pearson.est","phosphatase inhibitor",-0.4488,-1.09,0.341,824,0.676,"AS.1949490, bis.maltolato.oxovanadium.IV., sodium.stibogluconate, CID.5458317, BVT.948, alexidine, GSK2830371",0.467245621007502,0.170053304058364,FALSE +"H1648","Pearson.est","phosphodiesterase inhibitor",0.25243,0.713,0.829,1085,1,"cilostamide, EMD.53998, enoximone, anagrelide, avanafil, trequinsin, papaverine, zardaverine, GSK256066, YM.976",0.0814454694497265,0,FALSE +"H1648","Pearson.est","PI3K inhibitor",-0.34208,-0.831,0.665,724,0.845,"NVP.BEZ235, voxtalisib, pilaralisib, PI3K.IN.2, YM.201636, TG100.115, PKI.179, BGT226, TG.100713, LY303511, GSK2126458, AZD6482, PF.04691502, LY3023414, GDC.0941, CUDC.907, CH5132799, SB.2343",0.177178354696895,0.0731432910503077,FALSE +"H1648","Pearson.est","PLK inhibitor",0.22137,0.636,0.911,1129,1,"HMN.214, GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.0404816230270017,0,FALSE +"H1648","Pearson.est","potassium channel blocker",0.20742,0.594,0.925,304,1,"dofetilide, mepivacaine, oleoylethanolamide",0.0338582672609674,0,FALSE +"H1648","Pearson.est","PPAR receptor agonist",-0.33588,-0.82,0.674,1277,0.843,"pterostilbene",0.17134010346468,0.0741724253752577,FALSE +"H1648","Pearson.est","progesterone receptor agonist",-0.35992,-0.874,0.645,1318,0.852,"melengestrol.acetate, danazol",0.190440285364732,0.0695604052332999,FALSE +"H1648","Pearson.est","proteasome inhibitor",0.41601,1.22,0.212,92,0.849,"MG.132, carfilzomib",0.673664139071249,0.0710923097560473,FALSE +"H1648","Pearson.est","protein synthesis inhibitor",0.32281,0.911,0.534,279,0.904,"clofoctol, homoharringtonine, cycloheximide, anguidine, bruceantin, chloramphenicol.palmitate, methacycline, harringtonine, puromycin",0.272458742971444,0.0438315695246367,FALSE +"H1648","Pearson.est","protein tyrosine kinase inhibitor",-0.30155,-0.731,0.783,705,0.895,"rheochrysidin, CP.724714, PP.121, NVP.TAE226, mubritinib, BMS.599626",0.106238237942057,0.048176964684088,FALSE +"H1648","Pearson.est","RAF inhibitor",0.30484,0.859,0.593,90,0.964,"AZ.628, vemurafenib, LGX818",0.226945306635737,0.0159229660971692,FALSE +"H1648","Pearson.est","RET tyrosine kinase inhibitor",0.3202,0.95,0.51,24,0.875,"vandetanib",0.292429823902064,0.0579919469776868,FALSE +"H1648","Pearson.est","retinoid receptor agonist",-0.45689,-1.13,0.307,1210,0.66,"fenretinide, adapalene, bexarotene",0.512861624522813,0.180456064458131,FALSE +"H1648","Pearson.est","ribonucleotide reductase inhibitor",-0.28703,-0.685,0.858,777,0.915,"clofarabine, hydroxyurea, cytarabine, fludarabine, cladribine, pentostatin",0.0665127121512946,0.0385789059335517,FALSE +"H1648","Pearson.est","serotonin receptor agonist",-0.61357,-1.48,0.0746,1012,0.774,"zolmitriptan, NAN.190, ipsapirone, aripiprazole",1.12726117252733,0.111259039317107,FALSE +"H1648","Pearson.est","serotonin receptor antagonist",-0.52947,-1.31,0.181,1370,0.694,"lurasidone, aripiprazole",0.742321425130815,0.158640529545145,FALSE +"H1648","Pearson.est","sodium channel blocker",-0.42555,-1.02,0.441,1049,0.729,"oxcarbazepine, A.803467, triamterene, ajmaline, quinidine, lappaconite",0.355561410532161,0.137272471682025,FALSE +"H1648","Pearson.est","src inhibitor",0.36599,1.04,0.407,18,0.792,"dasatinib, saracatinib",0.39040559077478,0.101274818410506,FALSE +"H1648","Pearson.est","sterol demethylase inhibitor",-0.57205,-1.4,0.0997,1184,0.664,"terconazole, ketoconazole",1.00130484168834,0.177831920631982,FALSE +"H1648","Pearson.est","TGF beta receptor inhibitor",-0.34196,-0.831,0.711,1387,0.845,"adaprev",0.148130399270234,0.0731432910503077,FALSE +"H1648","Pearson.est","thymidylate synthase inhibitor",0.50783,1.47,0.112,276,0.52,"capecitabine, doxifluridine, ftorafur, carmofur",0.950781977329818,0.283996656365201,FALSE +"H1648","Pearson.est","topoisomerase inhibitor",-0.21768,-0.523,0.975,834,0.986,"nemorubicin, camptothecin, valrubicin, voreloxin, etoposide.phosphate, rubitecan, SN.38, TAS.103, genz.644282, fleroxacin, dexrazoxane, irinotecan",0.0109953843014632,0.0061230850587888,FALSE +"H1648","Pearson.est","tubulin polymerization inhibitor",0.29075,0.831,0.611,388,0.92,"mebendazole, paclitaxel, BNC105, CYT.997, vincristine, vindesine, epothilone.b, oxibendazole, taltobulin, verubulin, vinorelbine, dolastatin.10, fosbretabulin, podophyllotoxin",0.213958789757446,0.0362121726544447,FALSE +"H1648","Pearson.est","tyrosine kinase inhibitor",0.18939,0.554,0.978,24,1,"dasatinib, vandetanib",0.00966114521239857,0,FALSE +"H1648","Pearson.est","VEGFR inhibitor",-0.29167,-0.711,0.813,931,0.902,"telatinib, RAF265, orantinib, sunitinib, cabozantinib, PD.173074, sorafenib, axitinib, linifanib, ENMD.2076, lenvatinib, MK.2461, lucitanib, tivozanib, MGCD.265, KI.8751",0.0899094544059319,0.0447934624580583,FALSE +"H1648","Pearson.est","vitamin D receptor agonist",-0.52263,-1.29,0.179,1199,0.655,"maxacalcitol, tacalcitol, paricalcitol",0.747146969020107,0.183758700008217,FALSE +"H1975","Pearson.est","EGFR inhibitor",0.45153,1.29,0.158,154,0.732,"pelitinib, canertinib, vandetanib, BMS.690514, afatinib, XL.647, rociletinib, erlotinib, brigatinib, dacomitinib, AZD8931, lapatinib, neratinib, poziotinib, CUDC.101",0.801342913045577,0.135488918941608,FALSE +"H1975","Pearson.est","Abl kinase inhibitor",-0.59683,-1.46,0.0846,1103,1,"metatinib, flumatinib, nilotinib, KW.2449, imatinib, ponatinib, tozasertib",1.07262963696098,0,FALSE +"H1975","Pearson.est","acetylcholine receptor agonist",-0.4732,-1.15,0.306,1168,0.613,"nicotine, nefiracetam, pilocarpine",0.51427857351842,0.212539525481585,FALSE +"H1975","Pearson.est","acetylcholine receptor antagonist",-0.54511,-1.32,0.144,1020,0.602,"dicycloverine, iododexetimide, methscopolamine",0.84163750790475,0.220403508742175,FALSE +"H1975","Pearson.est","adenosine receptor antagonist",-0.47511,-1.14,0.328,812,0.613,"sulmazole, CGS.15943, istradefylline, MRS.1220, SCH.58261",0.484126156288321,0.212539525481585,FALSE +"H1975","Pearson.est","adrenergic receptor agonist",-0.47212,-1.15,0.307,1118,0.613,"A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.512861624522813,0.212539525481585,FALSE +"H1975","Pearson.est","adrenergic receptor antagonist",0.43364,1.24,0.208,247,0.642,"prazosin, vincamine, RS.17053, practolol, imiloxan, dihydroergocristine, atenolol...., levobunolol, idazoxan",0.681936665037238,0.192464971931147,FALSE +"H1975","Pearson.est","AKT inhibitor",-0.44939,-1.09,0.368,1018,0.694,"triciribine, uprosertib, ONC201, A.674563, CCT128930",0.434152181326482,0.158640529545145,FALSE +"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.33814,-0.825,0.697,1263,0.845,"alectinib, AP26113, DMH1",0.156767221901991,0.0731432910503077,FALSE +"H1975","Pearson.est","androgen receptor antagonist",-0.59789,-1.45,0.0876,1005,0.697,"nilutamide, flutamide, bicalutamide",1.05749589383192,0.156767221901991,FALSE +"H1975","Pearson.est","antioxidant",-0.53452,-1.3,0.18,1358,0.579,"benfotiamine, trolox",0.744727494896694,0.237321436272564,FALSE +"H1975","Pearson.est","AP inhibitor",0.58908,1.65,0.0595,46,0.633,"birinapant, GDC.0152",1.22548303427145,0.198596289982645,FALSE +"H1975","Pearson.est","ATPase inhibitor",0.266,0.739,0.783,3,1,"k.strophanthidin",0.106238237942057,0,FALSE +"H1975","Pearson.est","Aurora kinase inhibitor",-0.5926,-1.45,0.0772,1105,0.697,"barasertib.HQPA, aurora.a.inhibitor.i, CCT129202, AMG900, ENMD.2076, SNS.314, KW.2449, AT.9283, MK.8745, PF.03814735, barasertib, hesperadin, tozasertib",1.11238269966426,0.156767221901991,FALSE +"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.5205,-1.28,0.18,796,0.595,"azithromycin, valnemulin, azalomycin.b, josamycin, tilmicosin, radezolid, dirithromycin",0.744727494896694,0.22548303427145,FALSE +"H1975","Pearson.est","bacterial DNA gyrase inhibitor",0.53795,1.49,0.103,152,0.447,"finafloxacin, sarafloxacin, novobiocin",0.987162775294828,0.349692476868064,FALSE +"H1975","Pearson.est","BCL inhibitor",-0.44202,-1.07,0.378,1111,0.671,"gossypol, ABT.737",0.422508200162775,0.173277479831008,FALSE +"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.58512,-1.44,0.103,1103,0.573,"metatinib, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.987162775294828,0.24184537803261,FALSE +"H1975","Pearson.est","benzodiazepine receptor agonist",0.26308,0.738,0.751,47,0.97,"ZK.93423, gamma.aminobutyric.acid",0.124360062995832,0.0132282657337552,FALSE +"H1975","Pearson.est","bromodomain inhibitor",-0.48436,-1.19,0.248,961,0.599,"JQ1...., PFI.1, I.BET151, bromosporine",0.605548319173784,0.222573177610689,FALSE +"H1975","Pearson.est","calcium channel blocker",-0.51556,-1.23,0.219,1157,0.591,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",0.659555885159882,0.228412519118745,FALSE +"H1975","Pearson.est","CC chemokine receptor antagonist",-0.3502,-0.843,0.666,634,0.854,"UNBS.5162, RS.504393, MK.0812, SB.225002, PF.04136309, navarixin",0.176525770829699,0.068542129310995,FALSE +"H1975","Pearson.est","CDK inhibitor",-0.39343,-0.953,0.511,939,0.776,"palbociclib, indisulam, BMS.265246, AZD5438, JNJ.7706621, NU6027, kenpaullone, ribociclib, abemaciclib, indirubin, R547, arcyriaflavin.a",0.291579099865287,0.110138278741812,FALSE +"H1975","Pearson.est","CHK inhibitor",0.53401,1.49,0.0842,121,0.447,"SCH.900776, CHIR.124, LY2603618",1.07468790850035,0.349692476868064,FALSE +"H1975","Pearson.est","cyclooxygenase inhibitor",-0.3051,-0.74,0.812,1006,0.862,"metoxibutropate, piroxicam, FK.3311, indoprofen, tepoxalin, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.0904439707588247,0.0644927341752872,FALSE +"H1975","Pearson.est","cytochrome P450 inhibitor",0.24741,0.718,0.791,166,0.957,"PF.4981517, morin",0.101823516502323,0.0190880622231565,FALSE +"H1975","Pearson.est","DNA alkylating agent",-0.41597,-1.03,0.439,926,0.709,"streptozotocin, ifosfamide, carmustine, temozolomide, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.357535479757879,0.149353764816933,FALSE +"H1975","Pearson.est","DNA inhibitor",-0.41781,-1.01,0.448,1019,0.708,"carmustine, carboplatin, primaquine, pibenzimol, metronidazole, tirapazamine, melphalan, mechlorethamine",0.348721986001856,0.149966742310231,FALSE +"H1975","Pearson.est","DNA methyltransferase inhibitor",0.32672,0.909,0.5,242,0.894,"decitabine, SGI.1027, azacitidine",0.301029995663981,0.0486624812040823,FALSE +"H1975","Pearson.est","DNA polymerase inhibitor",0.31458,0.869,0.613,995,0.924,"cephalomannine, menadione, famciclovir, adefovir.dipivoxil, idoxuridine, trifluridine, cidofovir, foscarnet",0.212539525481585,0.0343280287798933,FALSE +"H1975","Pearson.est","DNA synthesis inhibitor",-0.32748,-0.786,0.741,773,0.85,"nelarabine, cisplatin, artesunate, azodicarbonamide, estramustine.phosphate, CB.10.277, enocitabine, altretamine, mitomycin.c",0.130181792020672,0.0705810742857073,FALSE +"H1975","Pearson.est","dopamine receptor antagonist",-0.39325,-0.963,0.505,950,0.777,"raclopride, amisulpride, UH.232...., paliperidone, nemonapride, lurasidone, mesoridazine",0.296708621881339,0.109578981199086,FALSE +"H1975","Pearson.est","estrogen receptor agonist",0.45122,1.22,0.231,37,0.549,"levonorgestrel, PPT",0.636388020107856,0.260427655549908,FALSE +"H1975","Pearson.est","estrogen receptor antagonist",-0.74758,-1.79,0.00951,1290,0.45,"toremifene, fulvestrant, danazol",2.02181948306259,0.346787486224656,FALSE +"H1975","Pearson.est","FGFR inhibitor",-0.5862,-1.43,0.0995,1145,0.49,"PD.173074, MK.2461, lenvatinib, erdafitinib, lucitanib",1.00217691925427,0.309803919971486,FALSE +"H1975","Pearson.est","FLT3 inhibitor",-0.61733,-1.48,0.069,1112,1,"sunitinib, midostaurin, ENMD.2076, tandutinib, KW.2449, sorafenib, GTP.14564, TG.101348, quizartinib, ponatinib, tozasertib",1.16115090926274,0,FALSE +"H1975","Pearson.est","glucocorticoid receptor agonist",0.43796,1.23,0.224,294,0.592,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, triamcinolone.acetonide, ciclesonide, halcinonide, prednisolone, fluocinolone.acetonide, desonide, fludroxycortide",0.649751981665837,0.22767829327708,FALSE +"H1975","Pearson.est","glutamate receptor antagonist",0.26673,0.75,0.754,165,1,"SIB.1757, latrepirdine, kynurenic.acid",0.122628654130226,0,FALSE +"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.48809,-1.19,0.268,1123,0.599,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, indirubin, CHIR.98014",0.571865205971211,0.222573177610689,FALSE +"H1975","Pearson.est","growth factor receptor inhibitor",-0.55162,-1.33,0.133,872,0.615,"lestaurtinib, GSK1904529A, AZD3463, GSK1838705A, GW.441756",0.876148359032914,0.211124884224583,FALSE +"H1975","Pearson.est","HCV inhibitor",0.36415,1.02,0.402,52,0.842,"daclatasvir",0.39577394691553,0.0746879085003505,FALSE +"H1975","Pearson.est","HDAC inhibitor",-0.49198,-1.21,0.245,1270,0.607,"trichostatin.a, givinostat, vorinostat, M.344, R306465, RG2833, resminostat, RGFP966",0.610833915635468,0.216811308924742,FALSE +"H1975","Pearson.est","histamine receptor antagonist",-0.34126,-0.826,0.675,1170,0.861,"tecastemizole, lafutidine, BF2.649, epinastine",0.170696227168975,0.0649968485463452,FALSE +"H1975","Pearson.est","HMGCR inhibitor",-0.56358,-1.38,0.107,1281,0.571,"lovastatin, fluvastatin",0.97061622231479,0.243363891754152,FALSE +"H1975","Pearson.est","HSP inhibitor",0.57273,1.56,0.0717,304,0.572,"BIIB021, KW.2478, SNX.5422, alvespimycin, SNX.2112, NVP.AUY922, VER.49009, ganetespib",1.1444808443322,0.242603971206976,FALSE +"H1975","Pearson.est","JAK inhibitor",-0.3292,-0.815,0.685,872,0.824,"lestaurtinib, pacritinib, LY2784544, AZD1480, CEP.33779, AT.9283, TG.101348, TG.101209, tozasertib",0.164309428507574,0.0840727883028842,FALSE +"H1975","Pearson.est","KIT inhibitor",-0.51244,-1.24,0.219,1112,0.597,"sunitinib, midostaurin, tandutinib, sorafenib, imatinib, lenvatinib, KI.8751, masitinib",0.659555885159882,0.224025668870631,FALSE +"H1975","Pearson.est","MDM inhibitor",-0.42641,-1.02,0.439,1120,0.707,"serdemetan, RITA",0.357535479757879,0.150580586203101,FALSE +"H1975","Pearson.est","MEK inhibitor",0.66027,1.83,0.0412,158,0.6,"selumetinib, trametinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, AZD8330, TAK.733, cobimetinib, PD.198306, PD.0325901",1.38510278396687,0.221848749616356,FALSE +"H1975","Pearson.est","MET inhibitor",-0.67436,-1.65,0.0275,1403,0.719,"NVP.BVU972, AMG458",1.56066730616974,0.143271109617117,FALSE +"H1975","Pearson.est","microtubule inhibitor",-0.13971,-0.337,1,766,1,"cabazitaxel, colchicine, estramustine.phosphate, D.64131",0,0,FALSE +"H1975","Pearson.est","mTOR inhibitor",-0.38761,-0.944,0.529,722,0.772,"deforolimus, NVP.BEZ235, voxtalisib, temsirolimus, PKI.179, OSI.027, torin.2, MLN0128, sirolimus, LY303511, XL388, GSK2126458, torin.1, PF.04691502, LY3023414, ku.0063794, AZD2014, WYE.354, SB.2343",0.276544327964814,0.112382699664264,FALSE +"H1975","Pearson.est","NFkB pathway inhibitor",-0.2749,-0.665,0.859,819,0.914,"parthenolide, curcumin, bortezomib, bindarit, EVP4593, betulinic.acid",0.0660068361687577,0.0390538042661686,FALSE +"H1975","Pearson.est","opioid receptor agonist",-0.44164,-1.07,0.383,798,0.671,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.416801226031377,0.173277479831008,FALSE +"H1975","Pearson.est","p38 MAPK inhibitor",-0.43447,-1.06,0.397,1300,0.672,"SB.239063, skepinone.l",0.401209493236885,0.172630726946175,FALSE +"H1975","Pearson.est","PARP inhibitor",-0.6051,-1.45,0.0755,1160,0.697,"AG.14361, PJ.34, niraparib, E7449",1.12205304837081,0.156767221901991,FALSE +"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.51173,-1.27,0.19,1112,0.556,"sunitinib, linifanib, crenolanib, axitinib, tandutinib, sorafenib, imatinib, lenvatinib, ponatinib, KI.8751, masitinib",0.721246399047171,0.254925208417942,FALSE +"H1975","Pearson.est","phosphatase inhibitor",-0.52899,-1.3,0.173,913,0.579,"AS.1949490, sodium.stibogluconate, bis.maltolato.oxovanadium.IV., CID.5458317, alexidine, BVT.948, GSK2830371",0.761953896871205,0.237321436272564,FALSE +"H1975","Pearson.est","phosphodiesterase inhibitor",0.25191,0.717,0.778,155,0.915,"cilostamide, EMD.53998",0.109020403010311,0.0385789059335517,FALSE +"H1975","Pearson.est","PI3K inhibitor",-0.37949,-0.922,0.557,740,0.794,"pilaralisib, NVP.BEZ235, voxtalisib, YM.201636, PKI.179, PI3K.IN.2, TG100.115, TG.100713, BGT226, LY303511, AZD6482, GSK2126458, PF.04691502, LY3023414, GDC.0941, CUDC.907, CH5132799, SB.2343",0.254144804826271,0.100179497572904,FALSE +"H1975","Pearson.est","PLK inhibitor",0.24844,0.704,0.833,1090,0.893,"HMN.214, GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.0793549985932124,0.0491485411114536,FALSE +"H1975","Pearson.est","potassium channel blocker",0.23757,0.663,0.878,303,0.869,"dofetilide, mepivacaine, oleoylethanolamide",0.0565054840938974,0.0609802235513335,FALSE +"H1975","Pearson.est","PPAR receptor agonist",-0.31787,-0.78,0.743,1255,0.842,"pterostilbene",0.129011186239425,0.0746879085003505,FALSE +"H1975","Pearson.est","progesterone receptor agonist",-0.37393,-0.916,0.569,1151,0.767,"dienogest, melengestrol.acetate, danazol",0.244887733604929,0.115204636051019,FALSE +"H1975","Pearson.est","proteasome inhibitor",0.4225,1.18,0.274,104,0.569,"carfilzomib, MG.132",0.562249437179612,0.244887733604929,FALSE +"H1975","Pearson.est","protein synthesis inhibitor",0.34789,0.963,0.471,147,0.902,"homoharringtonine, bruceantin, cycloheximide, clofoctol, chloramphenicol.palmitate, anguidine",0.326979092871104,0.0447934624580583,FALSE +"H1975","Pearson.est","protein tyrosine kinase inhibitor",-0.24162,-0.585,0.935,947,0.968,"NVP.TAE226, mubritinib, BMS.599626",0.0291883891274822,0.0141246426916063,FALSE +"H1975","Pearson.est","RAF inhibitor",0.28963,0.824,0.663,90,0.969,"AZ.628, LGX818, vemurafenib",0.178486471595227,0.0136762229492347,FALSE +"H1975","Pearson.est","RET tyrosine kinase inhibitor",-0.35619,-0.868,0.635,1112,0.832,"sunitinib, cabozantinib, sorafenib",0.197226274708024,0.0798766737092761,FALSE +"H1975","Pearson.est","retinoid receptor agonist",-0.56103,-1.36,0.101,1283,0.581,"fenretinide, adapalene, bexarotene",0.995678626217357,0.235823867609669,FALSE +"H1975","Pearson.est","ribonucleotide reductase inhibitor",-0.31425,-0.761,0.754,780,0.851,"cytarabine, hydroxyurea, clofarabine, fludarabine, cladribine, pentostatin",0.122628654130226,0.0700704399154121,FALSE +"H1975","Pearson.est","serotonin receptor agonist",-0.59748,-1.43,0.108,975,0.49,"zolmitriptan, NAN.190, ipsapirone, aripiprazole",0.96657624451305,0.309803919971486,FALSE +"H1975","Pearson.est","serotonin receptor antagonist",-0.48294,-1.15,0.302,1331,0.613,"lurasidone, aripiprazole",0.519993057042849,0.212539525481585,FALSE +"H1975","Pearson.est","sodium channel blocker",-0.4458,-1.08,0.36,1002,0.692,"oxcarbazepine, A.803467, cibenzoline, triamterene, ajmaline, quinidine, lappaconite",0.443697499232713,0.159893905543242,FALSE +"H1975","Pearson.est","src inhibitor",-0.38744,-0.921,0.561,1203,0.777,"PP.1, KX2.391, masitinib",0.251037138743839,0.109578981199086,FALSE +"H1975","Pearson.est","sterol demethylase inhibitor",-0.59575,-1.44,0.0976,1153,0.573,"terconazole, ketoconazole",1.01055018233331,0.24184537803261,FALSE +"H1975","Pearson.est","TGF beta receptor inhibitor",0.33732,0.932,0.504,271,0.906,"repsox, SB.525334, LY2109761",0.297569463554475,0.0428718023231869,FALSE +"H1975","Pearson.est","thymidylate synthase inhibitor",0.46176,1.28,0.153,217,0.649,"capecitabine, doxifluridine, ftorafur",0.815308569182401,0.187755303199631,FALSE +"H1975","Pearson.est","topoisomerase inhibitor",-0.30055,-0.733,0.794,859,0.854,"valrubicin, topotecan, etoposide.phosphate, voreloxin, nemorubicin, camptothecin, SN.38, rubitecan, genz.644282, TAS.103, fleroxacin, dexrazoxane, irinotecan",0.100179497572904,0.068542129310995,FALSE +"H1975","Pearson.est","tubulin polymerization inhibitor",0.24947,0.682,0.829,404,0.882,"mebendazole, CYT.997, paclitaxel, BNC105, vincristine, vindesine, taltobulin, epothilone.b, oxibendazole, vinorelbine, fenbendazole, dolastatin.10, podophyllotoxin, verubulin",0.0814454694497265,0.0545314148681803,FALSE +"H1975","Pearson.est","tyrosine kinase inhibitor",-0.20373,-0.492,0.98,1112,0.998,"sunitinib, cabozantinib, BMS.599626, sorafenib, GTP.14564, UNC2250",0.00877392430750515,0.000869458712628891,FALSE +"H1975","Pearson.est","VEGFR inhibitor",-0.33319,-0.816,0.713,1112,0.841,"sunitinib, linifanib, cabozantinib, PD.173074, ENMD.2076, axitinib, sorafenib, MK.2461, lenvatinib, MGCD.265, lucitanib, tivozanib, KI.8751",0.146910470148134,0.0752040042020878,FALSE +"H1975","Pearson.est","vitamin D receptor agonist",-0.52272,-1.27,0.206,1150,0.556,"maxacalcitol, paricalcitol, tacalcitol",0.686132779630847,0.254925208417942,FALSE +"HCC78","Pearson.est","EGFR inhibitor",0.32835,0.938,0.496,233,0.653,"pelitinib, canertinib, erlotinib, vandetanib, afatinib, XL.647, brigatinib, BMS.690514, rociletinib, dacomitinib, poziotinib, PD.168393, AZD8931, lapatinib, neratinib",0.304518323509803,0.185086818724926,FALSE +"HCC78","Pearson.est","Abl kinase inhibitor",-0.57238,-1.4,0.102,1109,0.538,"nilotinib, metatinib, flumatinib, imatinib, KW.2449, ponatinib, tozasertib",0.991399828238082,0.269217724333611,FALSE +"HCC78","Pearson.est","acetylcholine receptor agonist",-0.39333,-0.96,0.51,1054,0.799,"nicotine, nefiracetam, pilocarpine",0.292429823902064,0.0974532206860086,FALSE +"HCC78","Pearson.est","acetylcholine receptor antagonist",-0.44155,-1.08,0.368,641,0.717,"darifenacin, diphemanil, dicycloverine, iododexetimide, methscopolamine",0.434152181326482,0.1444808443322,FALSE +"HCC78","Pearson.est","adenosine receptor antagonist",-0.55507,-1.32,0.138,1151,0.496,"MRS.1220, CGS.15943, SCH.58261",0.860120913598763,0.304518323509803,FALSE +"HCC78","Pearson.est","adrenergic receptor agonist",-0.40626,-0.981,0.497,1060,0.797,"A61603, clenbuterol, isoxsuprine, isoetharine, norepinephrine, buphenine",0.303643611266668,0.0985416786038876,FALSE +"HCC78","Pearson.est","adrenergic receptor antagonist",0.40319,1.13,0.29,231,0.751,"prazosin, vincamine, RS.17053, imiloxan, practolol, atenolol...., levobunolol, dihydroergocristine",0.537602002101044,0.124360062995832,FALSE +"HCC78","Pearson.est","AKT inhibitor",-0.57059,-1.4,0.122,994,0.538,"MK.2206, GDC.0068, triciribine, ONC201, CCT128930, uprosertib, A.674563",0.913640169325252,0.269217724333611,FALSE +"HCC78","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.32662,-0.809,0.697,987,0.788,"NVP.TAE684, CEP.37440, AZD3463, AP26113, alectinib, DMH1",0.156767221901991,0.103473782510445,FALSE +"HCC78","Pearson.est","androgen receptor antagonist",-0.46476,-1.13,0.319,792,0.726,"nilutamide, flutamide, bicalutamide",0.496209316942819,0.139063379299906,FALSE +"HCC78","Pearson.est","antioxidant",-0.41114,-0.991,0.49,1246,0.797,"benfotiamine, trolox",0.309803919971486,0.0985416786038876,FALSE +"HCC78","Pearson.est","AP inhibitor",0.61263,1.72,0.0342,27,0.402,"birinapant, GDC.0152",1.46597389394386,0.39577394691553,FALSE +"HCC78","Pearson.est","ATPase inhibitor",0.36731,1.09,0.351,119,0.681,"k.strophanthidin, ouabain, digitoxin",0.454692883534176,0.166852888087215,FALSE +"HCC78","Pearson.est","Aurora kinase inhibitor",-0.64598,-1.59,0.0338,1121,0.735,"CCT129202, CCT137690, barasertib.HQPA, aurora.a.inhibitor.i, KW.2449, ENMD.2076, SNS.314, PF.03814735, AMG900, MK.8745, AT.9283, barasertib, hesperadin, tozasertib",1.47108329972235,0.133712660915805,FALSE +"HCC78","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.63582,-1.55,0.0397,932,0.561,"azithromycin, azalomycin.b, josamycin, tilmicosin, valnemulin, radezolid, dirithromycin",1.40120949323689,0.251037138743839,FALSE +"HCC78","Pearson.est","bacterial DNA gyrase inhibitor",0.54756,1.55,0.0992,259,0.504,"finafloxacin, sarafloxacin, novobiocin, sparfloxacin",1.00348832784582,0.297569463554475,FALSE +"HCC78","Pearson.est","BCL inhibitor",-0.45426,-1.11,0.352,1198,0.721,"gossypol, ABT.737",0.453457336521869,0.142064735280571,FALSE +"HCC78","Pearson.est","Bcr.Abl kinase inhibitor",-0.55739,-1.36,0.125,1109,0.56,"nilotinib, metatinib, flumatinib, imatinib, ponatinib, tozasertib",0.903089986991944,0.2518119729938,FALSE +"HCC78","Pearson.est","benzodiazepine receptor agonist",0.28544,0.798,0.717,100,0.809,"ZK.93423, gamma.aminobutyric.acid, eprinomectin",0.1444808443322,0.0920514783877277,FALSE +"HCC78","Pearson.est","bromodomain inhibitor",-0.72862,-1.78,0.00664,1074,0.52,"OTX015, PFI.1, JQ1...., bromosporine, I.BET151",2.17783192063198,0.283996656365201,FALSE +"HCC78","Pearson.est","calcium channel blocker",-0.59375,-1.48,0.0612,1224,0.608,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.21324857785444,0.216096420727265,FALSE +"HCC78","Pearson.est","CC chemokine receptor antagonist",-0.49986,-1.2,0.255,1043,0.664,"SB.225002, PF.04136309, navarixin",0.593459819566045,0.177831920631982,FALSE +"HCC78","Pearson.est","CDK inhibitor",-0.51005,-1.23,0.207,1094,0.652,"AZD5438, NU6027, BMS.265246, palbociclib, indisulam, JNJ.7706621, ribociclib, kenpaullone, abemaciclib, indirubin, R547, arcyriaflavin.a",0.684029654543082,0.18575240426808,FALSE +"HCC78","Pearson.est","CHK inhibitor",0.41098,1.14,0.265,167,0.832,"SCH.900776, CHIR.124, LY2603618",0.576754126063192,0.0798766737092761,FALSE +"HCC78","Pearson.est","cyclooxygenase inhibitor",-0.31447,-0.77,0.766,940,0.823,"FK.3311, curcumin, indoprofen, piroxicam, tepoxalin, naproxen, aspirin, pterostilbene, FR.122047, tryptanthrin",0.115771230367396,0.0846001647877302,FALSE +"HCC78","Pearson.est","cytochrome P450 inhibitor",0.35888,1.05,0.365,281,0.701,"PF.4981517, morin, eplerenone, metyrapone",0.437707135543525,0.154281982033341,FALSE +"HCC78","Pearson.est","DNA alkylating agent",-0.38882,-0.942,0.525,875,0.743,"streptozotocin, cisplatin, temozolomide, carmustine, ifosfamide, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.279840696594043,0.129011186239425,FALSE +"HCC78","Pearson.est","DNA inhibitor",-0.34224,-0.829,0.694,1081,0.787,"tirapazamine, pibenzimol, metronidazole, primaquine, melphalan, mechlorethamine",0.158640529545145,0.104025267640935,FALSE +"HCC78","Pearson.est","DNA methyltransferase inhibitor",-0.39166,-0.948,0.512,1036,0.766,"fdcyd, disulfiram, RG108",0.290730039024169,0.115771230367396,FALSE +"HCC78","Pearson.est","DNA polymerase inhibitor",-0.28552,-0.694,0.85,941,0.871,"idoxuridine, cidofovir, trifluridine, foscarnet",0.0705810742857073,0.0599818449923368,FALSE +"HCC78","Pearson.est","DNA synthesis inhibitor",-0.43121,-1.04,0.407,848,0.759,"cyclocytidine, azodicarbonamide, cisplatin, estramustine.phosphate, artesunate, anisomycin, altretamine, CB.10.277, enocitabine, mitomycin.c",0.39040559077478,0.11975822410452,FALSE +"HCC78","Pearson.est","dopamine receptor antagonist",-0.37789,-0.927,0.567,1071,0.738,"UH.232...., nemonapride, paliperidone, lurasidone, mesoridazine",0.246416941107093,0.131943638176958,FALSE +"HCC78","Pearson.est","estrogen receptor agonist",0.49882,1.46,0.0938,152,0.515,"levonorgestrel, PPT, ethinyl.estradiol",1.02779716162094,0.288192770958809,FALSE +"HCC78","Pearson.est","estrogen receptor antagonist",-0.65125,-1.58,0.0277,1242,0.581,"toremifene, danazol, fulvestrant",1.55752023093555,0.235823867609669,FALSE +"HCC78","Pearson.est","FGFR inhibitor",-0.54572,-1.34,0.143,1137,0.536,"PD.173074, MK.2461, lenvatinib, erdafitinib, lucitanib",0.844663962534938,0.27083521030723,FALSE +"HCC78","Pearson.est","FLT3 inhibitor",-0.61919,-1.51,0.0574,1021,0.594,"TG.02, midostaurin, sunitinib, pacritinib, tandutinib, GTP.14564, KW.2449, ENMD.2076, TG.101348, ponatinib, sorafenib, quizartinib, tozasertib",1.24108810760203,0.226213555018806,FALSE +"HCC78","Pearson.est","glucocorticoid receptor agonist",0.49733,1.39,0.124,279,0.443,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, halcinonide, fluocinolone.acetonide, triamcinolone.acetonide, ciclesonide, prednisolone, desonide, fludroxycortide",0.906578314837765,0.35359627377693,FALSE +"HCC78","Pearson.est","glutamate receptor antagonist",0.36664,1.03,0.4,248,0.68,"SIB.1757, latrepirdine, kynurenic.acid, CPP, JNJ.16259685, CGP.37849",0.397940008672038,0.167491087293764,FALSE +"HCC78","Pearson.est","glycogen synthase kinase inhibitor",-0.55919,-1.35,0.135,1234,0.546,"GSK.3.inhibitor.IX, LY2090314, kenpaullone, CHIR.98014, indirubin",0.869666231504994,0.262807357295263,FALSE +"HCC78","Pearson.est","growth factor receptor inhibitor",-0.49067,-1.2,0.23,844,0.664,"GSK1904529A, lestaurtinib, AZD3463, GSK1838705A, GW.441756",0.638272163982407,0.177831920631982,FALSE +"HCC78","Pearson.est","HCV inhibitor",0.2493,0.717,0.804,64,0.846,"daclatasvir",0.0947439512515487,0.0726296369609765,FALSE +"HCC78","Pearson.est","HDAC inhibitor",-0.56849,-1.39,0.103,1112,0.522,"PCI.24781, scriptaid, dacinostat, panobinostat, AR.42, trichostatin.a, givinostat, vorinostat, RG2833, M.344, R306465, resminostat, RGFP966",0.987162775294828,0.282329496997738,FALSE +"HCC78","Pearson.est","histamine receptor antagonist",-0.2994,-0.729,0.815,1079,0.846,"tecastemizole, lafutidine, cyproheptadine, BF2.649, epinastine",0.0888423912600234,0.0726296369609765,FALSE +"HCC78","Pearson.est","HMGCR inhibitor",-0.2106,-0.514,0.979,927,0.972,"fluvastatin, lovastatin",0.00921730819686218,0.0123337350737254,FALSE +"HCC78","Pearson.est","HSP inhibitor",0.48119,1.41,0.108,186,0.496,"BIIB021, KW.2478, SNX.2112, alvespimycin, SNX.5422",0.96657624451305,0.304518323509803,FALSE +"HCC78","Pearson.est","JAK inhibitor",-0.414,-1.01,0.452,918,0.8,"CEP.33779, lestaurtinib, LY2784544, TG.02, AZD1480, pacritinib, TG.101348, AT.9283, TG.101209, tozasertib",0.344861565188618,0.0969100130080564,FALSE +"HCC78","Pearson.est","KIT inhibitor",-0.43822,-1.09,0.334,953,0.718,"regorafenib, telatinib, midostaurin, sunitinib, tandutinib, lenvatinib, imatinib, sorafenib, KI.8751, masitinib",0.476253533188435,0.1438755557577,FALSE +"HCC78","Pearson.est","MDM inhibitor",-0.49633,-1.23,0.214,1232,0.652,"serdemetan, RITA",0.669586226650809,0.18575240426808,FALSE +"HCC78","Pearson.est","MEK inhibitor",0.62868,1.74,0.036,166,0.734,"selumetinib, AS.703026, trametinib, Ro.4987655, MEK1.2.inhibitor, TAK.733, AZD8330, PD.198306, cobimetinib, PD.0325901",1.44369749923271,0.134303940083929,FALSE +"HCC78","Pearson.est","MET inhibitor",-0.68743,-1.68,0.0228,1390,0.584,"NVP.BVU972, AMG458",1.64206515299955,0.233587152887601,FALSE +"HCC78","Pearson.est","microtubule inhibitor",-0.2272,-0.545,0.951,1327,0.974,"D.64131",0.0218194830625861,0.0114410431213845,FALSE +"HCC78","Pearson.est","mTOR inhibitor",-0.46212,-1.13,0.305,766,0.726,"deforolimus, AZD8055, GDC.0980, OSI.027, NVP.BEZ235, voxtalisib, WYE.125132, temsirolimus, PKI.179, torin.2, MLN0128, sirolimus, LY303511, XL388, torin.1, PF.04691502, LY3023414, ku.0063794, GSK2126458, WYE.354, AZD2014, SB.2343",0.515700160653214,0.139063379299906,FALSE +"HCC78","Pearson.est","NFkB pathway inhibitor",-0.39461,-0.959,0.514,1343,0.781,"EVP4593, betulinic.acid",0.289036881004724,0.1073489661227,FALSE +"HCC78","Pearson.est","opioid receptor agonist",-0.35051,-0.845,0.651,897,0.778,"salvinorin.a, trimebutine, cebranopadol",0.186419011431808,0.109020403010311,FALSE +"HCC78","Pearson.est","p38 MAPK inhibitor",-0.45257,-1.11,0.334,1326,0.721,"SB.239063, skepinone.l",0.476253533188435,0.142064735280571,FALSE +"HCC78","Pearson.est","PARP inhibitor",-0.58442,-1.41,0.101,1139,0.613,"AG.14361, PJ.34, niraparib, E7449",0.995678626217357,0.212539525481585,FALSE +"HCC78","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49034,-1.19,0.255,1108,0.661,"sunitinib, linifanib, crenolanib, axitinib, tandutinib, lenvatinib, imatinib, ponatinib, sorafenib, KI.8751, masitinib",0.593459819566045,0.17979854051436,FALSE +"HCC78","Pearson.est","phosphatase inhibitor",-0.43242,-1.05,0.386,769,0.759,"sodium.stibogluconate, bis.maltolato.oxovanadium.IV., AS.1949490, BVT.948, CID.5458317, alexidine, GSK2830371",0.413412695328245,0.11975822410452,FALSE +"HCC78","Pearson.est","phosphodiesterase inhibitor",0.29424,0.814,0.644,121,0.828,"cilostamide, EMD.53998",0.191114132640188,0.0819696632151199,FALSE +"HCC78","Pearson.est","PI3K inhibitor",-0.39446,-0.964,0.494,782,0.812,"GDC.0980, TG100.115, YM.201636, NVP.BEZ235, voxtalisib, PKI.179, AZD6482, TG.100713, BGT226, PI3K.IN.2, LY303511, PF.04691502, LY3023414, GDC.0941, GSK2126458, CUDC.907, CH5132799, SB.2343",0.306273051076353,0.0904439707588247,FALSE +"HCC78","Pearson.est","PLK inhibitor",-0.3918,-0.95,0.532,742,0.781,"GSK461364, NMS.1286937, BI.2536, rigosertib, volasertib, GW.843682X",0.274088367704952,0.1073489661227,FALSE +"HCC78","Pearson.est","potassium channel blocker",0.31137,0.945,0.474,999,0.731,"dofetilide, mepivacaine, oleoylethanolamide, ibutilide, meglitinide, ML133",0.324221658325915,0.13608262304214,FALSE +"HCC78","Pearson.est","PPAR receptor agonist",-0.37485,-0.908,0.576,1270,0.74,"pterostilbene",0.239577516576788,0.130768280269024,FALSE +"HCC78","Pearson.est","progesterone receptor agonist",-0.33876,-0.822,0.685,1321,0.784,"melengestrol.acetate, danazol",0.164309428507574,0.105683937315562,FALSE +"HCC78","Pearson.est","proteasome inhibitor",0.38967,1.12,0.305,108,0.69,"MG.132, carfilzomib",0.515700160653214,0.161150909262745,FALSE +"HCC78","Pearson.est","protein synthesis inhibitor",0.25938,0.761,0.754,282,0.825,"clofoctol, cycloheximide, chloramphenicol.palmitate, homoharringtonine, bruceantin, puromycin, methacycline, anguidine",0.122628654130226,0.0835460514500749,FALSE +"HCC78","Pearson.est","protein tyrosine kinase inhibitor",-0.41233,-0.995,0.473,1134,0.811,"mubritinib, NVP.TAE226, BMS.599626",0.325138859262188,0.090979145788844,FALSE +"HCC78","Pearson.est","RAF inhibitor",-0.30335,-0.737,0.792,1200,0.85,"RAF265, sorafenib, TAK.632",0.101274818410506,0.0705810742857073,FALSE +"HCC78","Pearson.est","RET tyrosine kinase inhibitor",-0.38638,-0.947,0.531,953,0.75,"regorafenib, sunitinib, cabozantinib, sorafenib",0.274905478918531,0.1249387366083,FALSE +"HCC78","Pearson.est","retinoid receptor agonist",-0.58651,-1.44,0.0824,1239,0.661,"adapalene, fenretinide, bexarotene",1.08407278830288,0.17979854051436,FALSE +"HCC78","Pearson.est","ribonucleotide reductase inhibitor",-0.35868,-0.869,0.618,828,0.786,"cytarabine, clofarabine, fludarabine, cladribine, pentostatin",0.209011524911184,0.104577453960592,FALSE +"HCC78","Pearson.est","serotonin receptor agonist",-0.54406,-1.32,0.152,1204,0.496,"ipsapirone, aripiprazole",0.818156412055227,0.304518323509803,FALSE +"HCC78","Pearson.est","serotonin receptor antagonist",-0.47017,-1.13,0.333,1189,0.726,"paliperidone, lurasidone, aripiprazole",0.47755576649368,0.139063379299906,FALSE +"HCC78","Pearson.est","sodium channel blocker",-0.44989,-1.09,0.344,1245,0.718,"quinidine, triamterene, ajmaline, lappaconite",0.46344155742847,0.1438755557577,FALSE +"HCC78","Pearson.est","src inhibitor",0.3661,1.02,0.381,19,0.644,"dasatinib, saracatinib",0.419075024324381,0.191114132640188,FALSE +"HCC78","Pearson.est","sterol demethylase inhibitor",-0.53445,-1.32,0.161,1026,0.496,"terconazole, ketoconazole",0.79317412396815,0.304518323509803,FALSE +"HCC78","Pearson.est","TGF beta receptor inhibitor",-0.3472,-0.854,0.658,1387,0.795,"adaprev",0.181774106386044,0.0996328713435297,FALSE +"HCC78","Pearson.est","thymidylate synthase inhibitor",0.32741,0.938,0.506,229,0.653,"capecitabine, ftorafur, doxifluridine",0.295849483160201,0.185086818724926,FALSE +"HCC78","Pearson.est","topoisomerase inhibitor",-0.37515,-0.919,0.563,772,0.736,"daunorubicin, exatecan.mesylate, valrubicin, beta.lapachone, voreloxin, etoposide.phosphate, camptothecin, topotecan, nemorubicin, fleroxacin, SN.38, dexrazoxane, TAS.103, rubitecan, genz.644282, irinotecan",0.249491605148654,0.133122185662501,FALSE +"HCC78","Pearson.est","tubulin polymerization inhibitor",0.15631,0.445,0.991,4,0.994,"mebendazole",0.00392634551472468,0.00261361560268669,FALSE +"HCC78","Pearson.est","tyrosine kinase inhibitor",-0.3472,-0.849,0.651,1108,0.787,"sunitinib, mubritinib, cabozantinib, NVP.TAE226, BMS.599626, GTP.14564, sorafenib, UNC2250",0.186419011431808,0.104025267640935,FALSE +"HCC78","Pearson.est","VEGFR inhibitor",-0.38416,-0.929,0.578,1108,0.75,"sunitinib, PD.173074, linifanib, MK.2461, axitinib, cabozantinib, RAF265, lenvatinib, ENMD.2076, MGCD.265, sorafenib, lucitanib, tivozanib, KI.8751",0.238072161579471,0.1249387366083,FALSE +"HCC78","Pearson.est","vitamin D receptor agonist",-0.59629,-1.43,0.0939,1291,0.615,"paricalcitol, maxacalcitol, tacalcitol",1.02733440773389,0.211124884224583,FALSE +"H2126","Pearson.est","EGFR inhibitor",0.41056,1.19,0.233,188,0.641,"pelitinib, canertinib, vandetanib, XL.647, BMS.690514, rociletinib, erlotinib, brigatinib, afatinib, CUDC.101, AZD8931, dacomitinib, neratinib, lapatinib",0.632644078973981,0.193141970481183,FALSE +"H2126","Pearson.est","Abl kinase inhibitor",-0.45944,-1.13,0.316,1106,0.721,"KW.2449, nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.500312917381596,0.142064735280571,FALSE +"H2126","Pearson.est","acetylcholine receptor agonist",-0.48685,-1.18,0.292,1222,0.662,"nicotine, nefiracetam, pilocarpine",0.534617148551582,0.1791420105603,FALSE +"H2126","Pearson.est","acetylcholine receptor antagonist",-0.46047,-1.11,0.341,664,0.666,"darifenacin, hyoscyamine, diphemanil, dicycloverine, methscopolamine, iododexetimide",0.467245621007502,0.176525770829699,FALSE +"H2126","Pearson.est","adenosine receptor antagonist",-0.53524,-1.25,0.207,869,0.677,"sulmazole, CGS.15943, istradefylline, MRS.1220, SCH.58261",0.684029654543082,0.169411331314856,FALSE +"H2126","Pearson.est","adrenergic receptor agonist",-0.38459,-0.932,0.528,773,0.81,"methyldopa, midodrine, xylazine, ritodrine, clenbuterol, A61603, isoxsuprine, isoetharine, buphenine, norepinephrine",0.277366077466188,0.0915149811213502,FALSE +"H2126","Pearson.est","adrenergic receptor antagonist",0.40152,1.13,0.29,267,0.63,"prazosin, vincamine, RS.17053, practolol, levobunolol, dihydroergocristine, idazoxan, atenolol....",0.537602002101044,0.200659450546418,FALSE +"H2126","Pearson.est","AKT inhibitor",-0.40313,-0.971,0.488,1085,0.777,"ONC201, uprosertib, A.674563, CCT128930",0.311580177997289,0.109578981199086,FALSE +"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.28079,-0.692,0.834,1190,0.903,"alectinib, AP26113, DMH1",0.0788339493622613,0.0443122496864942,FALSE +"H2126","Pearson.est","androgen receptor antagonist",-0.61302,-1.49,0.0584,1031,0.774,"nilutamide, flutamide, bicalutamide",1.2335871528876,0.111259039317107,FALSE +"H2126","Pearson.est","antioxidant",-0.50492,-1.21,0.248,1337,0.681,"benfotiamine, trolox",0.605548319173784,0.166852888087215,FALSE +"H2126","Pearson.est","AP inhibitor",0.5066,1.44,0.0789,49,0.638,"birinapant, GDC.0152",1.10292299679058,0.195179321278838,FALSE +"H2126","Pearson.est","ATPase inhibitor",0.28977,0.794,0.701,170,0.884,"k.strophanthidin, digitoxin, blebbistatin....",0.154281982033341,0.0535477349869269,FALSE +"H2126","Pearson.est","Aurora kinase inhibitor",-0.57664,-1.4,0.105,1083,0.789,"CCT129202, barasertib.HQPA, KW.2449, AMG900, aurora.a.inhibitor.i, SNS.314, AT.9283, barasertib, ENMD.2076, MK.8745, PF.03814735, hesperadin, tozasertib",0.978810700930062,0.10292299679058,FALSE +"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.55121,-1.36,0.137,910,0.764,"azalomycin.b, azithromycin, tilmicosin, josamycin, radezolid, dirithromycin",0.863279432843593,0.11690664142431,FALSE +"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.45362,1.22,0.194,159,0.658,"novobiocin, finafloxacin, sarafloxacin",0.712198270069774,0.181774106386044,FALSE +"H2126","Pearson.est","BCL inhibitor",-0.49332,-1.2,0.237,1147,0.644,"gossypol, ABT.737",0.625251653989896,0.191114132640188,FALSE +"H2126","Pearson.est","Bcr.Abl kinase inhibitor",-0.44422,-1.08,0.379,1118,0.684,"nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.421360790031928,0.164943898279884,FALSE +"H2126","Pearson.est","benzodiazepine receptor agonist",0.2112,0.588,0.916,78,1,"ZK.93423, gamma.aminobutyric.acid",0.0381045263321496,0,FALSE +"H2126","Pearson.est","bromodomain inhibitor",-0.56044,-1.36,0.125,1038,0.764,"JQ1...., PFI.1, I.BET151, bromosporine",0.903089986991944,0.11690664142431,FALSE +"H2126","Pearson.est","calcium channel blocker",-0.58841,-1.41,0.102,1238,0.857,"cinnarazine, mibefradil, carboxyamidotriazole, SR.33805",0.991399828238082,0.0670191780768018,FALSE +"H2126","Pearson.est","CC chemokine receptor antagonist",-0.3583,-0.874,0.636,936,0.835,"SB.225002, PF.04136309, navarixin",0.196542884351586,0.0783135245163979,FALSE +"H2126","Pearson.est","CDK inhibitor",-0.30728,-0.746,0.792,880,0.924,"AZD5438, indisulam, BMS.265246, abemaciclib, JNJ.7706621, ribociclib, kenpaullone, NU6027, indirubin, R547, arcyriaflavin.a",0.101274818410506,0.0343280287798933,FALSE +"H2126","Pearson.est","CHK inhibitor",0.5521,1.55,0.0769,91,0.58,"SCH.900776, CHIR.124, LY2603618",1.11407366019857,0.236572006437063,FALSE +"H2126","Pearson.est","cyclooxygenase inhibitor",-0.34065,-0.82,0.693,1078,0.868,"tepoxalin, indoprofen, piroxicam, FK.3311, metoxibutropate, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.159266765388193,0.0614802748235081,FALSE +"H2126","Pearson.est","cytochrome P450 inhibitor",0.26995,0.78,0.765,317,0.863,"PF.4981517, morin, eplerenone, metyrapone",0.116338564846382,0.0639892042847904,FALSE +"H2126","Pearson.est","DNA alkylating agent",-0.35047,-0.856,0.65,1079,0.846,"carmustine, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.187086643357144,0.0726296369609765,FALSE +"H2126","Pearson.est","DNA inhibitor",-0.44556,-1.09,0.365,1079,0.686,"carmustine, carboplatin, pibenzimol, metronidazole, primaquine, melphalan, tirapazamine, mechlorethamine",0.437707135543525,0.163675884293248,FALSE +"H2126","Pearson.est","DNA methyltransferase inhibitor",-0.31079,-0.752,0.77,1256,0.935,"RG108, disulfiram",0.113509274827518,0.0291883891274822,FALSE +"H2126","Pearson.est","DNA polymerase inhibitor",0.29375,0.828,0.671,1025,0.921,"cephalomannine, menadione, famciclovir, idoxuridine, adefovir.dipivoxil, trifluridine, foscarnet, cidofovir",0.173277479831008,0.0357403698031511,FALSE +"H2126","Pearson.est","DNA synthesis inhibitor",-0.33076,-0.801,0.714,1059,0.88,"estramustine.phosphate, enocitabine, CB.10.277, altretamine, mitomycin.c",0.146301788223826,0.0555173278498314,FALSE +"H2126","Pearson.est","dopamine receptor antagonist",-0.41521,-1.01,0.452,792,0.72,"ziprasidone, oxiperomide, domperidone, raclopride, amisulpride, paliperidone, nemonapride, UH.232...., lurasidone, mesoridazine",0.344861565188618,0.142667503568732,FALSE +"H2126","Pearson.est","estrogen receptor agonist",0.46711,1.29,0.179,47,0.602,"PPT, levonorgestrel",0.747146969020107,0.220403508742175,FALSE +"H2126","Pearson.est","estrogen receptor antagonist",-0.73645,-1.76,0.0093,1317,0.559,"toremifene, fulvestrant, danazol",2.03151705144606,0.252588192113577,FALSE +"H2126","Pearson.est","FGFR inhibitor",-0.64909,-1.57,0.0362,1036,1,"orantinib, PD.173074, MK.2461, erdafitinib, lenvatinib, lucitanib",1.44129142946683,0,FALSE +"H2126","Pearson.est","FLT3 inhibitor",-0.60396,-1.45,0.0832,1041,0.812,"sunitinib, sorafenib, KW.2449, midostaurin, TG.101348, tandutinib, ENMD.2076, ponatinib, GTP.14564, quizartinib, tozasertib",1.07987667370928,0.0904439707588247,FALSE +"H2126","Pearson.est","glucocorticoid receptor agonist",0.42079,1.18,0.241,285,0.595,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, fluocinolone.acetonide, prednisolone, desonide, halcinonide, triamcinolone.acetonide, fludroxycortide",0.617982957425132,0.22548303427145,FALSE +"H2126","Pearson.est","glutamate receptor antagonist",-0.27903,-0.68,0.852,1314,0.9,"MTPG, IEM1754",0.0695604052332999,0.0457574905606751,FALSE +"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.51053,-1.25,0.2,1134,0.677,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, indirubin, CHIR.98014",0.698970004336019,0.169411331314856,FALSE +"H2126","Pearson.est","growth factor receptor inhibitor",-0.45613,-1.11,0.307,788,0.666,"AZD3463, lestaurtinib, GSK1904529A, GSK1838705A, GW.441756",0.512861624522813,0.176525770829699,FALSE +"H2126","Pearson.est","HCV inhibitor",0.31429,0.891,0.515,56,0.847,"daclatasvir",0.288192770958809,0.0721165896692931,FALSE +"H2126","Pearson.est","HDAC inhibitor",-0.45423,-1.11,0.342,865,0.666,"ACY.1215, scriptaid, romidepsin, PCI.24781, dacinostat, entinostat, panobinostat, AR.42, vorinostat, givinostat, trichostatin.a, RG2833, resminostat, M.344, R306465, RGFP966",0.465973893943865,0.176525770829699,FALSE +"H2126","Pearson.est","histamine receptor antagonist",-0.36822,-0.906,0.575,1188,0.837,"lafutidine, BF2.649, tecastemizole, epinastine",0.24033215531037,0.07727454200674,FALSE +"H2126","Pearson.est","HMGCR inhibitor",-0.53292,-1.3,0.166,1285,0.713,"lovastatin, fluvastatin",0.779891911959945,0.146910470148134,FALSE +"H2126","Pearson.est","HSP inhibitor",0.56643,1.62,0.0522,292,0.681,"BIIB021, KW.2478, SNX.5422, NVP.AUY922, alvespimycin, SNX.2112, ganetespib, VER.49009",1.28232949699774,0.166852888087215,FALSE +"H2126","Pearson.est","JAK inhibitor",-0.30905,-0.743,0.782,966,0.91,"LY2784544, CEP.33779, AZD1480, AT.9283, TG.101348, TG.101209, tozasertib",0.106793246940152,0.0409586076789064,FALSE +"H2126","Pearson.est","KIT inhibitor",-0.44369,-1.06,0.396,1041,0.703,"sunitinib, sorafenib, midostaurin, imatinib, tandutinib, lenvatinib, KI.8751, masitinib",0.402304814074488,0.153044674980176,FALSE +"H2126","Pearson.est","MDM inhibitor",-0.46002,-1.12,0.329,1389,0.716,"RITA",0.482804102050026,0.145086977692144,FALSE +"H2126","Pearson.est","MEK inhibitor",0.66636,1.96,0.0178,165,0.286,"trametinib, selumetinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, cobimetinib, AZD8330, TAK.733, PD.198306, PD.0325901",1.74957999769111,0.543633966870957,FALSE +"H2126","Pearson.est","MET inhibitor",-0.62803,-1.53,0.0495,1415,1,"NVP.BVU972, AMG458",1.30539480106643,0,FALSE +"H2126","Pearson.est","microtubule inhibitor",0.19193,0.555,0.969,1172,1,"secnidazole, triclabendazole, vinflunine, vinblastine, podophyllotoxin, cytochalasin.b, cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.0136762229492347,0,FALSE +"H2126","Pearson.est","mTOR inhibitor",-0.43347,-1.03,0.438,1076,0.702,"XL388, sirolimus, LY303511, GSK2126458, LY3023414, PF.04691502, torin.1, AZD2014, WYE.354, ku.0063794, SB.2343",0.3585258894959,0.153662887870195,FALSE +"H2126","Pearson.est","NFkB pathway inhibitor",-0.22064,-0.537,0.959,1230,0.963,"EVP4593, betulinic.acid",0.0181813928293364,0.0163737128754655,FALSE +"H2126","Pearson.est","opioid receptor agonist",-0.52431,-1.3,0.181,927,0.713,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.742321425130815,0.146910470148134,FALSE +"H2126","Pearson.est","p38 MAPK inhibitor",-0.4687,-1.14,0.321,993,0.726,"SB.242235, TAK.715, SB.239063, skepinone.l",0.493494967595128,0.139063379299906,FALSE +"H2126","Pearson.est","PARP inhibitor",-0.62992,-1.51,0.0552,1179,0.86,"AG.14361, niraparib, PJ.34, E7449",1.2580609222708,0.0655015487564323,FALSE +"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49416,-1.2,0.259,1036,0.644,"orantinib, sunitinib, crenolanib, axitinib, sorafenib, linifanib, imatinib, tandutinib, ponatinib, lenvatinib, KI.8751, masitinib",0.586700235918748,0.191114132640188,FALSE +"H2126","Pearson.est","phosphatase inhibitor",-0.50958,-1.25,0.202,835,0.677,"bis.maltolato.oxovanadium.IV., AS.1949490, sodium.stibogluconate, CID.5458317, alexidine, GSK2830371, BVT.948",0.694648630553376,0.169411331314856,FALSE +"H2126","Pearson.est","phosphodiesterase inhibitor",0.21627,0.608,0.925,1137,1,"cilostamide, EMD.53998, enoximone, anagrelide, avanafil, papaverine, trequinsin, zardaverine, GSK256066, YM.976",0.0338582672609674,0,FALSE +"H2126","Pearson.est","PI3K inhibitor",-0.42425,-1.04,0.406,786,0.701,"TG100.115, YM.201636, PI3K.IN.2, pilaralisib, PKI.179, PI.828, voxtalisib, BGT226, TG.100713, LY303511, GSK2126458, AZD6482, LY3023414, PF.04691502, GDC.0941, CUDC.907, CH5132799, SB.2343",0.391473966422806,0.154281982033341,FALSE +"H2126","Pearson.est","PLK inhibitor",0.28799,0.819,0.662,1033,0.888,"HMN.214, GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.1791420105603,0.051587034221399,FALSE +"H2126","Pearson.est","potassium channel blocker",-0.21903,-0.54,0.955,1093,0.978,"ibutilide, meglitinide",0.0199966284162537,0.00966114521239857,FALSE +"H2126","Pearson.est","PPAR receptor agonist",-0.42109,-1.04,0.401,1324,0.701,"pterostilbene",0.396855627379818,0.154281982033341,FALSE +"H2126","Pearson.est","progesterone receptor agonist",-0.37235,-0.899,0.597,1145,0.811,"dienogest, melengestrol.acetate, danazol",0.224025668870631,0.090979145788844,FALSE +"H2126","Pearson.est","proteasome inhibitor",0.45951,1.31,0.16,83,0.66,"carfilzomib, MG.132",0.795880017344075,0.180456064458131,FALSE +"H2126","Pearson.est","protein synthesis inhibitor",0.34602,0.95,0.504,157,0.97,"homoharringtonine, cycloheximide, clofoctol, anguidine, bruceantin, chloramphenicol.palmitate",0.297569463554475,0.0132282657337552,FALSE +"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.29335,-0.708,0.821,669,0.901,"CP.724714, PP.121, rheochrysidin, NVP.TAE226, mubritinib, BMS.599626",0.0856568428805592,0.045275209020937,FALSE +"H2126","Pearson.est","RAF inhibitor",0.32618,0.922,0.508,87,0.896,"AZ.628, LGX818, vemurafenib",0.294136287716081,0.0476919903378748,FALSE +"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.32823,0.92,0.512,24,0.841,"vandetanib",0.290730039024169,0.0752040042020878,FALSE +"H2126","Pearson.est","retinoid receptor agonist",-0.49512,-1.21,0.241,1206,0.681,"fenretinide, adapalene, bexarotene",0.617982957425132,0.166852888087215,FALSE +"H2126","Pearson.est","ribonucleotide reductase inhibitor",-0.31139,-0.735,0.801,791,0.903,"hydroxyurea, cytarabine, fludarabine, clofarabine, cladribine, pentostatin",0.0963674839157623,0.0443122496864942,FALSE +"H2126","Pearson.est","serotonin receptor agonist",-0.56098,-1.35,0.136,1000,0.727,"zolmitriptan, NAN.190, ipsapirone, aripiprazole",0.866461091629782,0.138465589140962,FALSE +"H2126","Pearson.est","serotonin receptor antagonist",-0.50387,-1.22,0.232,1363,0.725,"lurasidone, aripiprazole",0.6345120151091,0.139661993429006,FALSE +"H2126","Pearson.est","sodium channel blocker",-0.39731,-0.959,0.513,1027,0.779,"A.803467, oxcarbazepine, ajmaline, triamterene, quinidine, lappaconite",0.289882634888184,0.108462542327436,FALSE +"H2126","Pearson.est","src inhibitor",-0.35528,-0.847,0.656,1185,0.843,"KX2.391, PP.1, masitinib",0.18309616062434,0.0741724253752577,FALSE +"H2126","Pearson.est","sterol demethylase inhibitor",-0.52827,-1.29,0.162,1142,0.694,"terconazole, ketoconazole",0.790484985457369,0.158640529545145,FALSE +"H2126","Pearson.est","TGF beta receptor inhibitor",-0.37231,-0.901,0.573,1379,0.826,"adaprev",0.24184537803261,0.0830199526796178,FALSE +"H2126","Pearson.est","thymidylate synthase inhibitor",0.48569,1.4,0.0915,247,0.585,"capecitabine, doxifluridine, ftorafur",1.03857890593355,0.23284413391782,FALSE +"H2126","Pearson.est","topoisomerase inhibitor",-0.23043,-0.569,0.941,890,0.979,"etoposide.phosphate, rubitecan, valrubicin, nemorubicin, voreloxin, SN.38, TAS.103, genz.644282, fleroxacin, dexrazoxane, irinotecan",0.0264103765727431,0.00921730819686218,FALSE +"H2126","Pearson.est","tubulin polymerization inhibitor",0.33226,0.949,0.498,399,0.898,"mebendazole, paclitaxel, BNC105, vindesine, CYT.997, vincristine, epothilone.b, taltobulin, vinorelbine, oxibendazole, fosbretabulin, verubulin, vinblastine, dolastatin.10, fenbendazole, podophyllotoxin",0.302770657240282,0.0467236633326956,FALSE +"H2126","Pearson.est","tyrosine kinase inhibitor",0.18499,0.522,0.989,24,0.976,"dasatinib, vandetanib",0.0048037084028206,0.0105501823333082,FALSE +"H2126","Pearson.est","VEGFR inhibitor",-0.30424,-0.734,0.805,1036,0.887,"orantinib, sunitinib, cabozantinib, axitinib, sorafenib, PD.173074, linifanib, ENMD.2076, MK.2461, lenvatinib, tivozanib, lucitanib, MGCD.265, KI.8751",0.0942041196321315,0.0520763801682736,FALSE +"H2126","Pearson.est","vitamin D receptor agonist",-0.5563,-1.33,0.144,922,0.732,"alfacalcidol, ercalcitriol, maxacalcitol, tacalcitol, paricalcitol",0.84163750790475,0.135488918941608,FALSE +"HCC827","Pearson.est","EGFR inhibitor",0.30987,0.87,0.578,215,1,"pelitinib, canertinib, brigatinib, vandetanib, XL.647, BMS.690514, rociletinib, erlotinib, afatinib, dacomitinib, lapatinib, AZD8931, poziotinib, neratinib",0.238072161579471,0,FALSE +"HCC827","Pearson.est","Abl kinase inhibitor",-0.58133,-1.42,0.104,1181,0.646,"imatinib, nilotinib, KW.2449, flumatinib, ponatinib, tozasertib",0.98296666070122,0.189767482004916,FALSE +"HCC827","Pearson.est","acetylcholine receptor agonist",-0.4664,-1.13,0.318,1162,0.694,"nicotine, nefiracetam, pilocarpine",0.497572880015567,0.158640529545145,FALSE +"HCC827","Pearson.est","acetylcholine receptor antagonist",-0.52689,-1.29,0.174,1027,0.536,"dicycloverine, iododexetimide, methscopolamine",0.7594507517174,0.27083521030723,FALSE +"HCC827","Pearson.est","adenosine receptor antagonist",-0.49502,-1.21,0.233,825,0.635,"sulmazole, istradefylline, MRS.1220, CGS.15943, SCH.58261",0.632644078973981,0.197226274708024,FALSE +"HCC827","Pearson.est","adrenergic receptor agonist",-0.43868,-1.07,0.379,1076,0.756,"clenbuterol, A61603, isoxsuprine, isoetharine, buphenine, norepinephrine",0.421360790031928,0.121478204498793,FALSE +"HCC827","Pearson.est","adrenergic receptor antagonist",0.42582,1.23,0.198,238,0.664,"prazosin, vincamine, RS.17053, practolol, imiloxan, dihydroergocristine, atenolol...., levobunolol, idazoxan",0.703334809738469,0.177831920631982,FALSE +"HCC827","Pearson.est","AKT inhibitor",-0.4402,-1.05,0.409,1017,0.776,"triciribine, ONC201, uprosertib, A.674563, CCT128930",0.388276691992658,0.110138278741812,FALSE +"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.34834,-0.835,0.667,1275,0.839,"alectinib, AP26113, DMH1",0.175874166083451,0.0762380391712997,FALSE +"HCC827","Pearson.est","androgen receptor antagonist",-0.64412,-1.58,0.0381,1060,0.57,"nilutamide, flutamide, bicalutamide",1.41907502432438,0.244125144327509,FALSE +"HCC827","Pearson.est","antioxidant",-0.52921,-1.31,0.158,1322,0.515,"benfotiamine, trolox",0.801342913045577,0.288192770958809,FALSE +"HCC827","Pearson.est","AP inhibitor",0.60206,1.78,0.0299,34,0.683,"birinapant, GDC.0152",1.52432881167557,0.165579296318467,FALSE +"HCC827","Pearson.est","ATPase inhibitor",0.28657,0.842,0.625,240,0.921,"k.strophanthidin, digitoxin, ouabain, blebbistatin....",0.204119982655925,0.0357403698031511,FALSE +"HCC827","Pearson.est","Aurora kinase inhibitor",-0.59922,-1.46,0.0793,1123,0.787,"CCT129202, barasertib.HQPA, AMG900, aurora.a.inhibitor.i, KW.2449, ENMD.2076, AT.9283, SNS.314, MK.8745, PF.03814735, barasertib, hesperadin, tozasertib",1.1007268126824,0.104025267640935,FALSE +"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.54228,-1.32,0.15,820,0.55,"valnemulin, azithromycin, azalomycin.b, josamycin, tilmicosin, radezolid, dirithromycin",0.823908740944319,0.259637310505756,FALSE +"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",0.47629,1.36,0.123,174,0.617,"finafloxacin, sarafloxacin, novobiocin",0.910094888560602,0.209714835966758,FALSE +"HCC827","Pearson.est","BCL inhibitor",-0.3903,-0.951,0.536,1125,0.784,"gossypol, ABT.737",0.27083521030723,0.105683937315562,FALSE +"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",-0.55909,-1.37,0.116,1181,0.525,"imatinib, nilotinib, flumatinib, ponatinib, tozasertib",0.935542010773082,0.279840696594043,FALSE +"HCC827","Pearson.est","benzodiazepine receptor agonist",0.23932,0.678,0.86,45,0.939,"ZK.93423, gamma.aminobutyric.acid",0.0655015487564323,0.0273344077338891,FALSE +"HCC827","Pearson.est","bromodomain inhibitor",-0.59094,-1.43,0.0841,1097,0.692,"PFI.1, JQ1...., bromosporine, I.BET151",1.07520400420209,0.159893905543242,FALSE +"HCC827","Pearson.est","calcium channel blocker",-0.57453,-1.4,0.0978,1201,0.582,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.0096611452124,0.235077015350112,FALSE +"HCC827","Pearson.est","CC chemokine receptor antagonist",-0.41567,-0.995,0.463,735,0.778,"RS.504393, MK.0812, SB.225002, PF.04136309, navarixin",0.334419008982047,0.109020403010311,FALSE +"HCC827","Pearson.est","CDK inhibitor",-0.42795,-1.04,0.42,1015,0.773,"AZD5438, indisulam, BMS.265246, NU6027, JNJ.7706621, ribociclib, abemaciclib, kenpaullone, indirubin, R547, arcyriaflavin.a",0.3767507096021,0.111820506081675,FALSE +"HCC827","Pearson.est","CHK inhibitor",0.48923,1.41,0.0952,122,0.645,"SCH.900776, CHIR.124, LY2603618",1.02136305161553,0.190440285364732,FALSE +"HCC827","Pearson.est","cyclooxygenase inhibitor",-0.3199,-0.774,0.741,901,0.846,"meloxicam, curcumin, metoxibutropate, FK.3311, indoprofen, tepoxalin, piroxicam, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.130181792020672,0.0726296369609765,FALSE +"HCC827","Pearson.est","cytochrome P450 inhibitor",0.28647,0.788,0.675,292,0.816,"PF.4981517, morin, eplerenone, metyrapone",0.170696227168975,0.0883098412461389,FALSE +"HCC827","Pearson.est","DNA alkylating agent",-0.4218,-1.01,0.45,961,0.771,"ifosfamide, carboplatin, temozolomide, carmustine, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.346787486224656,0.112945621949043,FALSE +"HCC827","Pearson.est","DNA inhibitor",-0.39887,-0.955,0.517,982,0.796,"carboplatin, carmustine, pibenzimol, primaquine, tirapazamine, metronidazole, melphalan, mechlorethamine",0.286509456906058,0.0990869322623309,FALSE +"HCC827","Pearson.est","DNA methyltransferase inhibitor",0.28671,0.814,0.685,149,0.816,"decitabine, SGI.1027",0.164309428507574,0.0883098412461389,FALSE +"HCC827","Pearson.est","DNA polymerase inhibitor",0.30278,0.855,0.6,1012,0.96,"cephalomannine, famciclovir, menadione, adefovir.dipivoxil, idoxuridine, trifluridine, cidofovir, foscarnet",0.221848749616356,0.0177287669604316,FALSE +"HCC827","Pearson.est","DNA synthesis inhibitor",-0.3576,-0.866,0.64,774,0.824,"cisplatin, anisomycin, nelarabine, artesunate, azodicarbonamide, altretamine, estramustine.phosphate, CB.10.277, enocitabine, mitomycin.c",0.193820026016113,0.0840727883028842,FALSE +"HCC827","Pearson.est","dopamine receptor antagonist",-0.42314,-1.03,0.421,1168,0.772,"paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.375717904164332,0.112382699664264,FALSE +"HCC827","Pearson.est","estrogen receptor agonist",0.43392,1.24,0.203,33,0.75,"PPT, levonorgestrel",0.692503962086787,0.1249387366083,FALSE +"HCC827","Pearson.est","estrogen receptor antagonist",-0.72358,-1.76,0.0105,1272,0.598,"toremifene, danazol, fulvestrant",1.97881070093006,0.223298816011589,FALSE +"HCC827","Pearson.est","FGFR inhibitor",-0.66853,-1.58,0.0273,1055,0.57,"orantinib, PD.173074, lenvatinib, erdafitinib, MK.2461, lucitanib",1.56383735295924,0.244125144327509,FALSE +"HCC827","Pearson.est","FLT3 inhibitor",-0.57019,-1.36,0.125,1198,0.515,"KW.2449, ENMD.2076, sorafenib, GTP.14564, TG.101348, tandutinib, quizartinib, ponatinib, tozasertib",0.903089986991944,0.288192770958809,FALSE +"HCC827","Pearson.est","glucocorticoid receptor agonist",0.37493,1.09,0.329,323,0.721,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, prednisolone, fluocinolone.acetonide, halcinonide, triamcinolone.acetonide, fludroxycortide, desonide",0.482804102050026,0.142064735280571,FALSE +"HCC827","Pearson.est","glutamate receptor antagonist",0.29574,0.835,0.622,130,0.877,"SIB.1757, latrepirdine, kynurenic.acid",0.206209615309181,0.0570004066339595,FALSE +"HCC827","Pearson.est","glycogen synthase kinase inhibitor",-0.55618,-1.38,0.115,1197,0.541,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, indirubin, CHIR.98014",0.939302159646388,0.266802734893431,FALSE +"HCC827","Pearson.est","growth factor receptor inhibitor",-0.55928,-1.33,0.138,867,0.557,"lestaurtinib, GSK1904529A, AZD3463, GSK1838705A, GW.441756",0.860120913598763,0.254144804826271,FALSE +"HCC827","Pearson.est","HCV inhibitor",-0.28909,-0.701,0.825,1277,0.875,"narlaprevir",0.0835460514500749,0.0579919469776868,FALSE +"HCC827","Pearson.est","HDAC inhibitor",-0.5403,-1.31,0.152,1211,0.515,"AR.42, panobinostat, trichostatin.a, givinostat, vorinostat, M.344, RG2833, resminostat, R306465, RGFP966",0.818156412055227,0.288192770958809,FALSE +"HCC827","Pearson.est","histamine receptor antagonist",-0.31971,-0.78,0.738,1064,0.854,"cyproheptadine, lafutidine, tecastemizole, BF2.649, epinastine",0.131943638176958,0.068542129310995,FALSE +"HCC827","Pearson.est","HMGCR inhibitor",-0.44162,-1.08,0.358,1179,0.76,"fluvastatin, lovastatin",0.446116973356126,0.119186407719209,FALSE +"HCC827","Pearson.est","HSP inhibitor",0.59706,1.69,0.0259,286,0.321,"BIIB021, KW.2478, alvespimycin, SNX.5422, SNX.2112, NVP.AUY922, VER.49009, ganetespib",1.58670023591875,0.493494967595128,FALSE +"HCC827","Pearson.est","JAK inhibitor",-0.33876,-0.824,0.699,936,0.839,"LY2784544, pacritinib, CEP.33779, AZD1480, AT.9283, TG.101348, TG.101209, tozasertib",0.155522824254319,0.0762380391712997,FALSE +"HCC827","Pearson.est","KIT inhibitor",-0.46876,-1.14,0.325,1041,0.696,"sunitinib, midostaurin, imatinib, sorafenib, lenvatinib, tandutinib, KI.8751, masitinib",0.488116639021126,0.157390760389438,FALSE +"HCC827","Pearson.est","MDM inhibitor",-0.40389,-0.969,0.514,1089,0.789,"serdemetan, RITA",0.289036881004724,0.10292299679058,FALSE +"HCC827","Pearson.est","MEK inhibitor",0.63532,1.77,0.0535,182,0.356,"selumetinib, AS.703026, trametinib, Ro.4987655, MEK1.2.inhibitor, TAK.733, AZD8330, cobimetinib, PD.198306, PD.0325901",1.27164621797877,0.448550002027125,FALSE +"HCC827","Pearson.est","MET inhibitor",-0.66043,-1.59,0.0256,1410,1,"NVP.BVU972, AMG458",1.59176003468815,0,FALSE +"HCC827","Pearson.est","microtubule inhibitor",-0.16612,-0.404,0.999,1061,0.997,"estramustine.phosphate, D.64131",0.000434511774017692,0.00130484168834428,FALSE +"HCC827","Pearson.est","mTOR inhibitor",-0.35438,-0.867,0.647,1012,0.84,"XL388, LY303511, torin.1, LY3023414, GSK2126458, PF.04691502, ku.0063794, AZD2014, WYE.354, SB.2343",0.1890957193313,0.0757207139381184,FALSE +"HCC827","Pearson.est","NFkB pathway inhibitor",-0.31328,-0.751,0.783,832,0.846,"bindarit, parthenolide, curcumin, bortezomib, EVP4593, betulinic.acid",0.106238237942057,0.0726296369609765,FALSE +"HCC827","Pearson.est","opioid receptor agonist",-0.41465,-1.01,0.447,778,0.771,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.349692476868064,0.112945621949043,FALSE +"HCC827","Pearson.est","p38 MAPK inhibitor",-0.45983,-1.1,0.359,1332,0.738,"SB.239063, skepinone.l",0.444905551421681,0.131943638176958,FALSE +"HCC827","Pearson.est","PARP inhibitor",-0.60047,-1.45,0.0779,1160,0.711,"AG.14361, niraparib, PJ.34, E7449",1.10846254232744,0.148130399270234,FALSE +"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.50659,-1.22,0.228,1041,0.672,"sunitinib, orantinib, linifanib, crenolanib, axitinib, imatinib, sorafenib, lenvatinib, tandutinib, ponatinib, KI.8751, masitinib",0.642065152999546,0.172630726946175,FALSE +"HCC827","Pearson.est","phosphatase inhibitor",-0.48986,-1.17,0.274,821,0.706,"sodium.stibogluconate, bis.maltolato.oxovanadium.IV., AS.1949490, CID.5458317, BVT.948, alexidine, GSK2830371",0.562249437179612,0.151195298948196,FALSE +"HCC827","Pearson.est","phosphodiesterase inhibitor",0.22949,0.639,0.896,1118,0.938,"cilostamide, EMD.53998, enoximone, anagrelide, avanafil, papaverine, trequinsin, zardaverine, GSK256066, YM.976",0.0476919903378748,0.0277971616209356,FALSE +"HCC827","Pearson.est","PI3K inhibitor",-0.37646,-0.905,0.576,843,0.83,"PI3K.IN.2, YM.201636, BGT226, TG100.115, TG.100713, LY303511, AZD6482, LY3023414, GSK2126458, PF.04691502, GDC.0941, CUDC.907, CH5132799, SB.2343",0.239577516576788,0.0809219076239261,FALSE +"HCC827","Pearson.est","PLK inhibitor",0.21999,0.603,0.926,1131,0.928,"HMN.214, GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.0333890133180656,0.0324520237811379,FALSE +"HCC827","Pearson.est","potassium channel blocker",-0.22232,-0.55,0.96,1074,0.988,"ibutilide, meglitinide",0.0177287669604316,0.00524305541237188,FALSE +"HCC827","Pearson.est","PPAR receptor agonist",-0.36223,-0.882,0.617,1305,0.852,"pterostilbene",0.209714835966758,0.0695604052332999,FALSE +"HCC827","Pearson.est","progesterone receptor agonist",-0.38876,-0.945,0.522,1341,0.776,"melengestrol.acetate, danazol",0.282329496997738,0.110138278741812,FALSE +"HCC827","Pearson.est","proteasome inhibitor",0.39024,1.11,0.299,104,0.754,"MG.132, carfilzomib",0.52432881167557,0.122628654130226,FALSE +"HCC827","Pearson.est","protein synthesis inhibitor",0.34201,0.936,0.531,151,1,"homoharringtonine, cycloheximide, clofoctol, bruceantin, anguidine, chloramphenicol.palmitate",0.274905478918531,0,FALSE +"HCC827","Pearson.est","protein tyrosine kinase inhibitor",-0.31799,-0.765,0.746,628,0.843,"PP.121, tyrphostin.A9, CP.724714, rheochrysidin, mubritinib, NVP.TAE226, BMS.599626",0.127261172527331,0.0741724253752577,FALSE +"HCC827","Pearson.est","RAF inhibitor",0.29939,0.863,0.615,76,1,"vemurafenib, AZ.628, LGX818",0.211124884224583,0,FALSE +"HCC827","Pearson.est","RET tyrosine kinase inhibitor",-0.33619,-0.821,0.702,1041,0.827,"sunitinib, cabozantinib, sorafenib",0.153662887870195,0.0824944904474534,FALSE +"HCC827","Pearson.est","retinoid receptor agonist",-0.50995,-1.21,0.246,1242,0.635,"adapalene, fenretinide, bexarotene",0.609064892896621,0.197226274708024,FALSE +"HCC827","Pearson.est","ribonucleotide reductase inhibitor",-0.32612,-0.789,0.725,882,0.856,"clofarabine, cytarabine, fludarabine, cladribine, pentostatin",0.139661993429006,0.0675262353228468,FALSE +"HCC827","Pearson.est","serotonin receptor agonist",-0.57104,-1.38,0.121,1244,0.541,"ipsapirone, aripiprazole",0.91721462968355,0.266802734893431,FALSE +"HCC827","Pearson.est","serotonin receptor antagonist",-0.47928,-1.16,0.299,1168,0.701,"paliperidone, lurasidone, aripiprazole",0.52432881167557,0.154281982033341,FALSE +"HCC827","Pearson.est","sodium channel blocker",-0.46433,-1.14,0.309,976,0.696,"oxcarbazepine, cibenzoline, A.803467, triamterene, ajmaline, quinidine, lappaconite",0.510041520575165,0.157390760389438,FALSE +"HCC827","Pearson.est","src inhibitor",-0.40403,-0.972,0.484,1185,0.803,"KX2.391, PP.1, masitinib",0.315154638355588,0.095284454721319,FALSE +"HCC827","Pearson.est","sterol demethylase inhibitor",-0.61435,-1.47,0.0696,1174,0.888,"terconazole, ketoconazole",1.15739076038944,0.051587034221399,FALSE +"HCC827","Pearson.est","TGF beta receptor inhibitor",-0.34185,-0.84,0.671,1375,0.848,"adaprev",0.173277479831008,0.0716041477432862,FALSE +"HCC827","Pearson.est","thymidylate synthase inhibitor",0.41914,1.16,0.273,113,0.727,"capecitabine, doxifluridine",0.563837352959244,0.138465589140962,FALSE +"HCC827","Pearson.est","topoisomerase inhibitor",-0.30184,-0.732,0.794,849,0.854,"valrubicin, etoposide.phosphate, topotecan, voreloxin, nemorubicin, camptothecin, SN.38, TAS.103, rubitecan, fleroxacin, genz.644282, dexrazoxane, irinotecan",0.100179497572904,0.068542129310995,FALSE +"HCC827","Pearson.est","tubulin polymerization inhibitor",0.2799,0.818,0.654,384,0.856,"mebendazole, CYT.997, BNC105, paclitaxel, vindesine, vincristine, epothilone.b, fenbendazole, taltobulin, verubulin, dolastatin.10, vinblastine, vinorelbine, oxibendazole, podophyllotoxin, fosbretabulin",0.184422251675733,0.0675262353228468,FALSE +"HCC827","Pearson.est","tyrosine kinase inhibitor",-0.21299,-0.518,0.971,1035,0.987,"NVP.TAE226, sunitinib, cabozantinib, sorafenib, GTP.14564, BMS.599626, UNC2250",0.0127807700919951,0.00568284733036327,FALSE +"HCC827","Pearson.est","VEGFR inhibitor",-0.35564,-0.875,0.639,1018,0.845,"RAF265, sunitinib, orantinib, linifanib, PD.173074, cabozantinib, axitinib, ENMD.2076, sorafenib, lenvatinib, MK.2461, MGCD.265, lucitanib, tivozanib, KI.8751",0.1944991418416,0.0731432910503077,FALSE +"HCC827","Pearson.est","vitamin D receptor agonist",-0.57307,-1.41,0.0948,1260,0.611,"maxacalcitol, paricalcitol, tacalcitol",1.02319166266193,0.213958789757446,FALSE +"CALU3","Pearson.est","EGFR inhibitor",0.38803,1.04,0.361,197,0.674,"pelitinib, canertinib, erlotinib, afatinib, brigatinib, XL.647, rociletinib, BMS.690514, vandetanib, PD.168393, poziotinib, AZD8931, neratinib, dacomitinib",0.442492798094342,0.17134010346468,FALSE +"CALU3","Pearson.est","Abl kinase inhibitor",-0.49386,-1.19,0.253,1064,0.687,"metatinib, nilotinib, flumatinib, KW.2449, imatinib, ponatinib, tozasertib",0.596879478824182,0.16304326294045,FALSE +"CALU3","Pearson.est","acetylcholine receptor agonist",-0.41186,-0.993,0.471,1112,0.713,"nicotine, nefiracetam, pilocarpine",0.326979092871104,0.146910470148134,FALSE +"CALU3","Pearson.est","acetylcholine receptor antagonist",-0.5596,-1.38,0.118,1035,0.445,"dicycloverine, iododexetimide, methscopolamine",0.928117992693875,0.351639989019068,FALSE +"CALU3","Pearson.est","adenosine receptor antagonist",-0.56199,-1.38,0.127,1213,0.445,"MRS.1220, CGS.15943, SCH.58261",0.896196279044043,0.351639989019068,FALSE +"CALU3","Pearson.est","adrenergic receptor agonist",-0.45512,-1.13,0.31,1141,0.637,"metaraminol, isoxsuprine, clenbuterol, isoetharine, norepinephrine, buphenine",0.508638306165727,0.19586056766465,FALSE +"CALU3","Pearson.est","adrenergic receptor antagonist",0.45011,1.24,0.196,281,0.756,"prazosin, vincamine, RS.17053, imiloxan, levobunolol, dihydroergocristine, idazoxan, atenolol...., practolol",0.707743928643524,0.121478204498793,FALSE +"CALU3","Pearson.est","AKT inhibitor",-0.48269,-1.22,0.229,1134,0.648,"triciribine, ONC201, CCT128930, uprosertib, A.674563",0.640164517660112,0.188424994129407,FALSE +"CALU3","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.2247,-0.551,0.946,983,0.971,"AZD3463, AP26113, CEP.37440, alectinib, DMH1",0.0241088635982073,0.0127807700919951,FALSE +"CALU3","Pearson.est","androgen receptor antagonist",-0.45809,-1.14,0.305,687,0.717,"cyproterone.acetate, RU.58841, nilutamide, flutamide, bicalutamide",0.515700160653214,0.1444808443322,FALSE +"CALU3","Pearson.est","antioxidant",-0.45616,-1.11,0.339,1307,0.633,"benfotiamine, trolox",0.469800301796918,0.198596289982645,FALSE +"CALU3","Pearson.est","AP inhibitor",0.74371,1.99,0.0134,30,0.242,"GDC.0152, birinapant",1.87289520163519,0.616184634019569,TRUE +"CALU3","Pearson.est","ATPase inhibitor",0.37978,1.07,0.372,121,0.727,"k.strophanthidin, digitoxin, ouabain",0.429457060118102,0.138465589140962,FALSE +"CALU3","Pearson.est","Aurora kinase inhibitor",-0.56645,-1.42,0.107,1048,0.494,"CCT129202, CCT137690, AT.9283, SNS.314, MK.8745, AMG900, ENMD.2076, PF.03814735, KW.2449, aurora.a.inhibitor.i, barasertib, hesperadin, tozasertib",0.97061622231479,0.306273051076353,FALSE +"CALU3","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.57026,-1.42,0.0977,855,0.494,"azalomycin.b, josamycin, tilmicosin, azithromycin, valnemulin, radezolid, dirithromycin",1.01010543628123,0.306273051076353,FALSE +"CALU3","Pearson.est","bacterial DNA gyrase inhibitor",0.49922,1.35,0.164,412,0.626,"finafloxacin, sarafloxacin, novobiocin, lomefloxacin, sparfloxacin, trovafloxacin, norfloxacin",0.785156151952302,0.20342566678957,FALSE +"CALU3","Pearson.est","BCL inhibitor",-0.45702,-1.13,0.317,1261,0.637,"ABT.737, gossypol",0.498940737782249,0.19586056766465,FALSE +"CALU3","Pearson.est","Bcr.Abl kinase inhibitor",-0.49183,-1.22,0.236,1064,0.648,"metatinib, nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.627087997029893,0.188424994129407,FALSE +"CALU3","Pearson.est","benzodiazepine receptor agonist",0.28464,0.773,0.754,35,0.904,"ZK.93423, gamma.aminobutyric.acid",0.122628654130226,0.0438315695246367,FALSE +"CALU3","Pearson.est","bromodomain inhibitor",-0.63522,-1.57,0.0542,1154,0.642,"PFI.1, JQ1...., I.BET151, bromosporine",1.26600071346161,0.192464971931147,FALSE +"CALU3","Pearson.est","calcium channel blocker",-0.55072,-1.36,0.142,1249,0.459,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",0.847711655616944,0.338187314462739,FALSE +"CALU3","Pearson.est","CC chemokine receptor antagonist",-0.4822,-1.18,0.277,868,0.652,"RS.504393, SB.225002, PF.04136309, navarixin",0.557520230935551,0.18575240426808,FALSE +"CALU3","Pearson.est","CDK inhibitor",-0.43302,-1.06,0.405,1071,0.649,"JNJ.7706621, BMS.265246, palbociclib, AZD5438, ribociclib, abemaciclib, NU6027, kenpaullone, R547, indirubin, arcyriaflavin.a",0.392544976785331,0.187755303199631,FALSE +"CALU3","Pearson.est","CHK inhibitor",0.53167,1.43,0.115,294,0.576,"SCH.900776, CHIR.124, LY2603618, PF.477736, LY2606368, AZD7762",0.939302159646388,0.239577516576788,FALSE +"CALU3","Pearson.est","cyclooxygenase inhibitor",-0.30451,-0.747,0.764,1011,0.848,"piroxicam, naproxen, curcumin, indoprofen, aspirin, tepoxalin, pterostilbene, FR.122047, tryptanthrin",0.11690664142431,0.0716041477432862,FALSE +"CALU3","Pearson.est","cytochrome P450 inhibitor",0.40775,1.16,0.238,312,0.616,"PF.4981517, morin, eplerenone, metyrapone",0.623423042943488,0.210419287835575,FALSE +"CALU3","Pearson.est","DNA alkylating agent",-0.35887,-0.875,0.601,804,0.776,"streptozotocin, carboplatin, temozolomide, cisplatin, ifosfamide, cyclophosphamide, carmustine, satraplatin, melphalan, mitomycin.c",0.22112552799726,0.110138278741812,FALSE +"CALU3","Pearson.est","DNA inhibitor",-0.38627,-0.955,0.505,1150,0.726,"carmustine, pibenzimol, primaquine, mechlorethamine, metronidazole, melphalan",0.296708621881339,0.139063379299906,FALSE +"CALU3","Pearson.est","DNA methyltransferase inhibitor",-0.28908,-0.724,0.811,1194,0.846,"disulfiram, RG108",0.090979145788844,0.0726296369609765,FALSE +"CALU3","Pearson.est","DNA polymerase inhibitor",0.21157,0.576,0.941,313,0.981,"cephalomannine, famciclovir, menadione",0.0264103765727431,0.0083309926200515,FALSE +"CALU3","Pearson.est","DNA synthesis inhibitor",-0.36752,-0.923,0.535,908,0.731,"azodicarbonamide, cisplatin, anisomycin, estramustine.phosphate, CB.10.277, artesunate, enocitabine, mitomycin.c",0.271646217978772,0.13608262304214,FALSE +"CALU3","Pearson.est","dopamine receptor antagonist",-0.39384,-0.965,0.488,1227,0.726,"paliperidone, nemonapride, lurasidone, mesoridazine",0.311580177997289,0.139063379299906,FALSE +"CALU3","Pearson.est","estrogen receptor agonist",0.43255,1.18,0.275,267,0.635,"levonorgestrel, PPT, ethinyl.estradiol, erteberel",0.560667306169737,0.197226274708024,FALSE +"CALU3","Pearson.est","estrogen receptor antagonist",-0.70105,-1.72,0.0157,1270,0.454,"toremifene, danazol, fulvestrant",1.80410034759077,0.342944147142896,FALSE +"CALU3","Pearson.est","FGFR inhibitor",-0.60473,-1.49,0.0699,984,0.69,"regorafenib, orantinib, PD.173074, lenvatinib, MK.2461, lucitanib, erdafitinib",1.15552282425432,0.161150909262745,FALSE +"CALU3","Pearson.est","FLT3 inhibitor",-0.64927,-1.57,0.0228,1124,0.642,"pacritinib, tandutinib, sunitinib, TG.101348, GTP.14564, ENMD.2076, KW.2449, sorafenib, quizartinib, ponatinib, tozasertib",1.64206515299955,0.192464971931147,FALSE +"CALU3","Pearson.est","glucocorticoid receptor agonist",0.5931,1.65,0.0605,278,0.434,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, halcinonide, fluocinolone.acetonide, prednisolone, ciclesonide, triamcinolone.acetonide, fludroxycortide, desonide, dexamethasone.acetate",1.21824462534753,0.362510270487489,FALSE +"CALU3","Pearson.est","glutamate receptor antagonist",0.38391,1.05,0.363,234,0.707,"SIB.1757, latrepirdine, kynurenic.acid, CPP, CGP.37849",0.440093374963888,0.150580586203101,FALSE +"CALU3","Pearson.est","glycogen synthase kinase inhibitor",-0.59869,-1.49,0.0715,1262,0.69,"LY2090314, CHIR.98014, GSK.3.inhibitor.IX, kenpaullone, indirubin",1.14569395819892,0.161150909262745,FALSE +"CALU3","Pearson.est","growth factor receptor inhibitor",-0.43489,-1.06,0.382,842,0.649,"lestaurtinib, AZD3463, GSK1838705A, GW.441756",0.417936637088291,0.187755303199631,FALSE +"CALU3","Pearson.est","HCV inhibitor",0.25798,0.706,0.85,1076,0.92,"daclatasvir, mericitabine, embelin, PSI.7976, Ro.9187, narlaprevir",0.0705810742857073,0.0362121726544447,FALSE +"CALU3","Pearson.est","HDAC inhibitor",-0.58982,-1.46,0.081,1097,0.605,"PCI.24781, scriptaid, dacinostat, entinostat, panobinostat, trichostatin.a, AR.42, vorinostat, givinostat, RGFP966, RG2833, R306465, M.344, resminostat",1.09151498112135,0.218244625347531,FALSE +"CALU3","Pearson.est","histamine receptor antagonist",-0.34977,-0.843,0.659,1103,0.761,"tecastemizole, cyproheptadine, BF2.649, lafutidine, epinastine",0.18111458540599,0.118615343229427,FALSE +"CALU3","Pearson.est","HMGCR inhibitor",-0.20101,-0.496,0.98,1180,0.979,"lovastatin",0.00877392430750515,0.00921730819686218,FALSE +"CALU3","Pearson.est","HSP inhibitor",0.53638,1.55,0.0631,201,0.476,"KW.2478, BIIB021, alvespimycin, SNX.2112, SNX.5422",1.19997064075587,0.322393047279507,FALSE +"CALU3","Pearson.est","JAK inhibitor",-0.34936,-0.874,0.637,1124,0.761,"pacritinib, AT.9283, TG.101348, TG.101209, tozasertib",0.19586056766465,0.118615343229427,FALSE +"CALU3","Pearson.est","KIT inhibitor",-0.46928,-1.13,0.311,1128,0.637,"telatinib, tandutinib, lenvatinib, sunitinib, imatinib, sorafenib, KI.8751, masitinib",0.507239610973163,0.19586056766465,FALSE +"CALU3","Pearson.est","MDM inhibitor",-0.47381,-1.18,0.284,1164,0.652,"serdemetan, RITA",0.546681659952962,0.18575240426808,FALSE +"CALU3","Pearson.est","MEK inhibitor",0.60038,1.65,0.0465,181,0.434,"Ro.4987655, selumetinib, AS.703026, trametinib, MEK1.2.inhibitor, TAK.733, PD.198306, AZD8330, PD.0325901, cobimetinib",1.33254704711005,0.362510270487489,FALSE +"CALU3","Pearson.est","MET inhibitor",-0.74291,-1.82,0.0102,1414,0.396,"NVP.BVU972, AMG458",1.99139982823808,0.402304814074488,FALSE +"CALU3","Pearson.est","microtubule inhibitor",0.22457,0.632,0.894,347,0.973,"secnidazole, triclabendazole, vinblastine, vinflunine",0.0486624812040823,0.0118871597316481,FALSE +"CALU3","Pearson.est","mTOR inhibitor",-0.48596,-1.22,0.249,930,0.648,"GDC.0980, WYE.125132, temsirolimus, NVP.BEZ235, torin.2, LY303511, PF.04691502, XL388, sirolimus, MLN0128, torin.1, LY3023414, GSK2126458, ku.0063794, AZD2014, WYE.354, SB.2343",0.603800652904264,0.188424994129407,FALSE +"CALU3","Pearson.est","NFkB pathway inhibitor",-0.3587,-0.872,0.621,1338,0.749,"EVP4593, betulinic.acid",0.20690839982342,0.125518182300534,FALSE +"CALU3","Pearson.est","opioid receptor agonist",-0.30449,-0.735,0.779,766,0.848,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.108462542327436,0.0716041477432862,FALSE +"CALU3","Pearson.est","p38 MAPK inhibitor",-0.39915,-0.988,0.477,1277,0.703,"SB.239063, skepinone.l",0.321481620959886,0.153044674980176,FALSE +"CALU3","Pearson.est","PARP inhibitor",-0.56085,-1.38,0.125,1286,0.445,"PJ.34, niraparib, E7449",0.903089986991944,0.351639989019068,FALSE +"CALU3","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.52698,-1.3,0.165,1128,0.554,"telatinib, axitinib, tandutinib, crenolanib, linifanib, lenvatinib, sunitinib, imatinib, sorafenib, ponatinib, KI.8751, masitinib",0.782516055786094,0.25649023527157,FALSE +"CALU3","Pearson.est","phosphatase inhibitor",-0.45414,-1.12,0.302,987,0.634,"bis.maltolato.oxovanadium.IV., CID.5458317, BVT.948, alexidine, GSK2830371",0.519993057042849,0.197910742118267,FALSE +"CALU3","Pearson.est","phosphodiesterase inhibitor",0.2694,0.73,0.782,166,0.928,"cilostamide, EMD.53998",0.106793246940152,0.0324520237811379,FALSE +"CALU3","Pearson.est","PI3K inhibitor",-0.42574,-1.03,0.416,930,0.685,"GDC.0980, TG.100713, NVP.BEZ235, LY303511, BGT226, TG100.115, PF.04691502, PI3K.IN.2, LY3023414, GDC.0941, GSK2126458, CUDC.907, CH5132799, SB.2343",0.380906669373257,0.164309428507574,FALSE +"CALU3","Pearson.est","PLK inhibitor",0.20958,0.57,0.951,1146,0.946,"HMN.214, NMS.1286937, BI.2536, GSK461364, volasertib, rigosertib, GW.843682X",0.0218194830625861,0.0241088635982073,FALSE +"CALU3","Pearson.est","potassium channel blocker",0.33773,0.92,0.493,961,0.687,"dofetilide, mepivacaine, oleoylethanolamide, meglitinide, ML133, ibutilide",0.30715308072277,0.16304326294045,FALSE +"CALU3","Pearson.est","PPAR receptor agonist",-0.38488,-0.935,0.528,1300,0.728,"pterostilbene",0.277366077466188,0.137868620686963,FALSE +"CALU3","Pearson.est","progesterone receptor agonist",-0.32306,-0.8,0.707,1310,0.793,"melengestrol.acetate, danazol",0.150580586203101,0.100726812682396,FALSE +"CALU3","Pearson.est","proteasome inhibitor",0.37456,1.01,0.384,154,0.604,"MG.132, carfilzomib",0.415668775632469,0.218963061378868,FALSE +"CALU3","Pearson.est","protein synthesis inhibitor",0.36332,1.03,0.419,111,0.648,"cycloheximide, clofoctol, bruceantin, chloramphenicol.palmitate, puromycin, homoharringtonine",0.377785977033705,0.188424994129407,FALSE +"CALU3","Pearson.est","protein tyrosine kinase inhibitor",-0.41779,-1.02,0.441,933,0.685,"tyrphostin.A9, NVP.TAE226, mubritinib, BMS.599626",0.355561410532161,0.164309428507574,FALSE +"CALU3","Pearson.est","RAF inhibitor",-0.34395,-0.853,0.648,1366,0.762,"sorafenib, TAK.632",0.188424994129407,0.1180450286604,FALSE +"CALU3","Pearson.est","RET tyrosine kinase inhibitor",-0.44483,-1.08,0.366,984,0.65,"regorafenib, cabozantinib, sunitinib, sorafenib",0.436518914605589,0.187086643357144,FALSE +"CALU3","Pearson.est","retinoid receptor agonist",-0.59488,-1.47,0.0745,1321,0.659,"adapalene, bexarotene, fenretinide",1.12784372725171,0.18111458540599,FALSE +"CALU3","Pearson.est","ribonucleotide reductase inhibitor",-0.38244,-0.95,0.514,844,0.718,"cytarabine, hydroxyurea, clofarabine, fludarabine, cladribine, pentostatin",0.289036881004724,0.1438755557577,FALSE +"CALU3","Pearson.est","serotonin receptor agonist",-0.56637,-1.41,0.117,1095,0.478,"NAN.190, ipsapirone, aripiprazole",0.931814138253838,0.320572103387881,FALSE +"CALU3","Pearson.est","serotonin receptor antagonist",-0.45977,-1.13,0.336,1227,0.637,"paliperidone, lurasidone, aripiprazole",0.473660722610156,0.19586056766465,FALSE +"CALU3","Pearson.est","sodium channel blocker",-0.45013,-1.08,0.366,1272,0.65,"quinidine, triamterene, lappaconite, ajmaline",0.436518914605589,0.187086643357144,FALSE +"CALU3","Pearson.est","src inhibitor",0.35567,0.973,0.438,27,0.631,"saracatinib, dasatinib",0.3585258894959,0.199970640755866,FALSE +"CALU3","Pearson.est","sterol demethylase inhibitor",-0.58389,-1.43,0.0946,1053,0.563,"terconazole, ketoconazole",1.02410886359821,0.249491605148654,FALSE +"CALU3","Pearson.est","TGF beta receptor inhibitor",0.36657,1.02,0.415,110,0.625,"repsox, SB.525334",0.381951903287907,0.204119982655925,FALSE +"CALU3","Pearson.est","thymidylate synthase inhibitor",0.41215,1.21,0.221,241,0.727,"capecitabine, doxifluridine, ftorafur",0.655607726314889,0.138465589140962,FALSE +"CALU3","Pearson.est","topoisomerase inhibitor",-0.33262,-0.809,0.71,1005,0.796,"etoposide.phosphate, TAS.103, SN.38, topotecan, nemorubicin, fleroxacin, dexrazoxane, genz.644282, rubitecan, irinotecan",0.148741651280925,0.0990869322623309,FALSE +"CALU3","Pearson.est","tubulin polymerization inhibitor",0.41293,1.18,0.254,353,0.635,"mebendazole, CYT.997, vincristine, paclitaxel, BNC105, epothilone.b, vindesine, verubulin, vinorelbine, dolastatin.10, vinblastine, oxibendazole",0.595166283380062,0.197226274708024,FALSE +"CALU3","Pearson.est","tyrosine kinase inhibitor",-0.29472,-0.711,0.806,904,0.846,"bafetinib, tyrphostin.A9, regorafenib, NVP.TAE226, cabozantinib, mubritinib, BMS.599626, sunitinib, GTP.14564, UNC2250, sorafenib",0.0936649581949093,0.0726296369609765,FALSE +"CALU3","Pearson.est","VEGFR inhibitor",-0.37757,-0.917,0.563,1019,0.725,"orantinib, foretinib, RAF265, cabozantinib, telatinib, PD.173074, axitinib, linifanib, lenvatinib, sunitinib, ENMD.2076, MK.2461, MGCD.265, lucitanib, sorafenib, tivozanib, KI.8751",0.249491605148654,0.139661993429006,FALSE +"CALU3","Pearson.est","vitamin D receptor agonist",-0.58269,-1.43,0.106,1288,0.563,"maxacalcitol, paricalcitol, tacalcitol",0.97469413473523,0.249491605148654,FALSE +"H2009","Pearson.est","EGFR inhibitor",0.33711,0.951,0.502,71,0.97,"pelitinib, canertinib, brigatinib, erlotinib, vandetanib, BMS.690514, rociletinib, XL.647, afatinib",0.299296282854981,0.0132282657337552,FALSE +"H2009","Pearson.est","Abl kinase inhibitor",-0.45177,-1.09,0.363,1087,0.814,"flumatinib, nilotinib, imatinib, KW.2449, ponatinib, tozasertib",0.440093374963888,0.0893755951107988,FALSE +"H2009","Pearson.est","acetylcholine receptor agonist",-0.43452,-1.06,0.404,1141,0.729,"nicotine, nefiracetam, pilocarpine",0.393618634889395,0.137272471682025,FALSE +"H2009","Pearson.est","acetylcholine receptor antagonist",-0.52396,-1.26,0.195,882,0.57,"diphemanil, dicycloverine, iododexetimide, methscopolamine",0.709965388637482,0.244125144327509,FALSE +"H2009","Pearson.est","adenosine receptor antagonist",-0.54367,-1.34,0.145,1178,0.601,"MRS.1220, CGS.15943, SCH.58261",0.838631997765025,0.22112552799726,FALSE +"H2009","Pearson.est","adrenergic receptor agonist",-0.42098,-1.02,0.446,1050,0.71,"A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.350665141287858,0.148741651280925,FALSE +"H2009","Pearson.est","adrenergic receptor antagonist",0.43772,1.25,0.233,217,0.633,"prazosin, vincamine, RS.17053, practolol, imiloxan, levobunolol, atenolol...., dihydroergocristine, idazoxan",0.632644078973981,0.198596289982645,FALSE +"H2009","Pearson.est","AKT inhibitor",-0.53931,-1.3,0.157,1168,0.594,"triciribine, ONC201, CCT128930, uprosertib, A.674563",0.804100347590766,0.226213555018806,FALSE +"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27959,-0.684,0.869,1007,0.896,"AZD3463, CEP.37440, AP26113, alectinib, DMH1",0.0609802235513335,0.0476919903378748,FALSE +"H2009","Pearson.est","androgen receptor antagonist",-0.54501,-1.29,0.172,946,0.557,"nilutamide, flutamide, bicalutamide",0.764471553092451,0.254144804826271,FALSE +"H2009","Pearson.est","antioxidant",-0.4472,-1.07,0.385,1273,0.779,"benfotiamine, trolox",0.414539270491499,0.108462542327436,FALSE +"H2009","Pearson.est","AP inhibitor",0.60406,1.8,0.039,32,0.292,"GDC.0152, birinapant",1.4089353929735,0.534617148551582,FALSE +"H2009","Pearson.est","ATPase inhibitor",0.30959,0.884,0.55,205,0.845,"k.strophanthidin, digitoxin, ouabain, blebbistatin....",0.259637310505756,0.0731432910503077,FALSE +"H2009","Pearson.est","Aurora kinase inhibitor",-0.62806,-1.55,0.0389,1097,0.69,"CCT129202, CCT137690, barasertib.HQPA, KW.2449, aurora.a.inhibitor.i, AMG900, AT.9283, MK.8745, ENMD.2076, SNS.314, PF.03814735, barasertib, hesperadin, tozasertib",1.41005039867429,0.161150909262745,FALSE +"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.63497,-1.53,0.0538,921,0.623,"valnemulin, azalomycin.b, azithromycin, josamycin, tilmicosin, radezolid, dirithromycin",1.26921772433361,0.20551195334083,FALSE +"H2009","Pearson.est","bacterial DNA gyrase inhibitor",0.4705,1.27,0.212,138,0.69,"finafloxacin, sarafloxacin, novobiocin",0.673664139071249,0.161150909262745,FALSE +"H2009","Pearson.est","BCL inhibitor",-0.54946,-1.34,0.139,1294,0.601,"gossypol, ABT.737",0.856985199745905,0.22112552799726,FALSE +"H2009","Pearson.est","Bcr.Abl kinase inhibitor",-0.42968,-1.03,0.427,1087,0.728,"flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.369572124974976,0.137868620686963,FALSE +"H2009","Pearson.est","benzodiazepine receptor agonist",0.23563,0.698,0.819,37,0.961,"gamma.aminobutyric.acid, ZK.93423",0.0867160982395816,0.0172766123314547,FALSE +"H2009","Pearson.est","bromodomain inhibitor",-0.76289,-1.83,0.0013,1108,0.314,"OTX015, PFI.1, JQ1...., bromosporine, I.BET151",2.88605664769316,0.503070351926785,FALSE +"H2009","Pearson.est","calcium channel blocker",-0.6204,-1.49,0.0575,1249,0.557,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.24033215531037,0.254144804826271,FALSE +"H2009","Pearson.est","CC chemokine receptor antagonist",-0.52495,-1.25,0.208,1046,0.542,"SB.225002, PF.04136309, navarixin",0.681936665037238,0.266000713461613,FALSE +"H2009","Pearson.est","CDK inhibitor",-0.5256,-1.29,0.181,1014,0.557,"palbociclib, AZD5438, TG.02, BMS.265246, JNJ.7706621, NU6027, indisulam, ribociclib, abemaciclib, kenpaullone, indirubin, R547, arcyriaflavin.a",0.742321425130815,0.254144804826271,FALSE +"H2009","Pearson.est","CHK inhibitor",0.4894,1.45,0.105,318,0.728,"SCH.900776, CHIR.124, LY2603618, LY2606368, PF.477736, AZD7762",0.978810700930062,0.137868620686963,FALSE +"H2009","Pearson.est","cyclooxygenase inhibitor",-0.3088,-0.744,0.787,881,0.858,"metoxibutropate, meloxicam, FK.3311, curcumin, indoprofen, piroxicam, tepoxalin, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.104025267640935,0.0665127121512946,FALSE +"H2009","Pearson.est","cytochrome P450 inhibitor",0.40522,1.14,0.301,250,0.688,"PF.4981517, morin, eplerenone, metyrapone",0.521433504406157,0.162411561764489,FALSE +"H2009","Pearson.est","DNA alkylating agent",-0.35278,-0.864,0.633,778,0.781,"streptozotocin, cisplatin, temozolomide, carboplatin, ifosfamide, carmustine, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.198596289982645,0.1073489661227,FALSE +"H2009","Pearson.est","DNA inhibitor",-0.35593,-0.874,0.616,998,0.797,"tirapazamine, carmustine, metronidazole, pibenzimol, primaquine, mechlorethamine, melphalan",0.210419287835575,0.0985416786038876,FALSE +"H2009","Pearson.est","DNA methyltransferase inhibitor",-0.38696,-0.951,0.544,1042,0.827,"fdcyd, RG108, disulfiram",0.26440110030182,0.0824944904474534,FALSE +"H2009","Pearson.est","DNA polymerase inhibitor",0.28542,0.789,0.749,1037,0.919,"cephalomannine, famciclovir, menadione, adefovir.dipivoxil, idoxuridine, cidofovir, trifluridine, foscarnet",0.125518182300534,0.0366844886138887,FALSE +"H2009","Pearson.est","DNA synthesis inhibitor",-0.31715,-0.772,0.752,854,0.868,"artesunate, anisomycin, azodicarbonamide, estramustine.phosphate, altretamine, CB.10.277, enocitabine, mitomycin.c",0.123782159408358,0.0614802748235081,FALSE +"H2009","Pearson.est","dopamine receptor antagonist",-0.38244,-0.926,0.56,1091,0.794,"UH.232...., nemonapride, paliperidone, lurasidone, mesoridazine",0.2518119729938,0.100179497572904,FALSE +"H2009","Pearson.est","estrogen receptor agonist",0.4742,1.35,0.142,46,0.782,"PPT, levonorgestrel",0.847711655616944,0.106793246940152,FALSE +"H2009","Pearson.est","estrogen receptor antagonist",-0.66459,-1.62,0.0286,1276,0.875,"toremifene, danazol, fulvestrant",1.54363396687096,0.0579919469776868,FALSE +"H2009","Pearson.est","FGFR inhibitor",-0.57235,-1.39,0.104,894,0.606,"regorafenib, orantinib, PD.173074, lenvatinib, MK.2461, erdafitinib, lucitanib",0.98296666070122,0.217527375833714,FALSE +"H2009","Pearson.est","FLT3 inhibitor",-0.61228,-1.47,0.0796,1024,0.547,"TG.02, pacritinib, sunitinib, GTP.14564, KW.2449, tandutinib, TG.101348, ENMD.2076, ponatinib, sorafenib, quizartinib, tozasertib",1.09908693226233,0.262012673666569,FALSE +"H2009","Pearson.est","glucocorticoid receptor agonist",0.45798,1.3,0.154,291,0.751,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, fluocinolone.acetonide, ciclesonide, halcinonide, fludroxycortide, prednisolone, desonide, triamcinolone.acetonide",0.812479279163537,0.124360062995832,FALSE +"H2009","Pearson.est","glutamate receptor antagonist",0.33489,0.926,0.485,283,0.874,"SIB.1757, latrepirdine, kynurenic.acid, CGP.37849, CPP, JNJ.16259685",0.314258261397736,0.058488567365597,FALSE +"H2009","Pearson.est","glycogen synthase kinase inhibitor",-0.54172,-1.33,0.155,1209,0.55,"GSK.3.inhibitor.IX, LY2090314, kenpaullone, CHIR.98014, indirubin",0.809668301829709,0.259637310505756,FALSE +"H2009","Pearson.est","growth factor receptor inhibitor",-0.47638,-1.16,0.284,904,0.696,"lestaurtinib, AZD3463, GSK1838705A, GW.441756",0.546681659952962,0.157390760389438,FALSE +"H2009","Pearson.est","HCV inhibitor",-0.21592,-0.52,0.963,1262,0.986,"narlaprevir",0.0163737128754655,0.0061230850587888,FALSE +"H2009","Pearson.est","HDAC inhibitor",-0.55568,-1.33,0.14,1040,0.55,"scriptaid, PCI.24781, entinostat, dacinostat, panobinostat, AR.42, trichostatin.a, vorinostat, givinostat, RG2833, resminostat, M.344, R306465, RGFP966",0.853871964321762,0.259637310505756,FALSE +"H2009","Pearson.est","histamine receptor antagonist",-0.31257,-0.755,0.766,1063,0.859,"cyproheptadine, tecastemizole, BF2.649, lafutidine, epinastine",0.115771230367396,0.0660068361687577,FALSE +"H2009","Pearson.est","HMGCR inhibitor",0.24827,0.697,0.845,1090,0.914,"pitavastatin, simvastatin, mevastatin, atorvastatin, fluvastatin, lovastatin",0.0731432910503077,0.0390538042661686,FALSE +"H2009","Pearson.est","HSP inhibitor",0.42702,1.22,0.245,324,0.608,"BIIB021, KW.2478, SNX.2112, alvespimycin, SNX.5422, VER.49009, NVP.AUY922",0.610833915635468,0.216096420727265,FALSE +"H2009","Pearson.est","JAK inhibitor",-0.38101,-0.917,0.59,876,0.792,"CEP.33779, lestaurtinib, LY2784544, TG.02, pacritinib, AZD1480, TG.101348, AT.9283, TG.101209, tozasertib",0.229147988357856,0.101274818410506,FALSE +"H2009","Pearson.est","KIT inhibitor",-0.43848,-1.06,0.387,1149,0.729,"sunitinib, imatinib, lenvatinib, tandutinib, sorafenib, KI.8751, masitinib",0.412289034981089,0.137272471682025,FALSE +"H2009","Pearson.est","MDM inhibitor",-0.43514,-1.06,0.394,1177,0.729,"serdemetan, RITA",0.404503778174426,0.137272471682025,FALSE +"H2009","Pearson.est","MEK inhibitor",0.63625,1.81,0.0224,161,0.557,"selumetinib, trametinib, AS.703026, MEK1.2.inhibitor, Ro.4987655, TAK.733, AZD8330, cobimetinib, PD.198306, PD.0325901",1.64975198166584,0.254144804826271,FALSE +"H2009","Pearson.est","MET inhibitor",-0.65206,-1.58,0.0333,1411,0.762,"NVP.BVU972, AMG458",1.47755576649368,0.1180450286604,FALSE +"H2009","Pearson.est","microtubule inhibitor",-0.20399,-0.495,0.972,1304,0.979,"D.64131",0.0123337350737254,0.00921730819686218,FALSE +"H2009","Pearson.est","mTOR inhibitor",-0.44505,-1.08,0.368,700,0.809,"deforolimus, AZD8055, PF.05212384, NVP.BEZ235, PKI.179, GDC.0980, temsirolimus, WYE.125132, OSI.027, voxtalisib, MLN0128, torin.2, sirolimus, LY303511, XL388, torin.1, LY3023414, PF.04691502, GSK2126458, WYE.354, ku.0063794, AZD2014, SB.2343",0.434152181326482,0.0920514783877277,FALSE +"H2009","Pearson.est","NFkB pathway inhibitor",-0.33387,-0.805,0.719,1330,0.837,"EVP4593, betulinic.acid",0.143271109617117,0.07727454200674,FALSE +"H2009","Pearson.est","opioid receptor agonist",-0.38969,-0.946,0.543,820,0.816,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.265200170411153,0.0883098412461389,FALSE +"H2009","Pearson.est","p38 MAPK inhibitor",-0.44491,-1.07,0.375,1338,0.779,"SB.239063, skepinone.l",0.425968732272281,0.108462542327436,FALSE +"H2009","Pearson.est","PARP inhibitor",-0.59784,-1.44,0.0731,1122,0.513,"AG.14361, PJ.34, E7449, niraparib",1.13608262304214,0.289882634888184,FALSE +"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.47729,-1.17,0.278,1100,0.699,"axitinib, linifanib, crenolanib, sunitinib, imatinib, lenvatinib, tandutinib, ponatinib, sorafenib, KI.8751, masitinib",0.555955204081924,0.155522824254319,FALSE +"H2009","Pearson.est","phosphatase inhibitor",-0.42714,-1.04,0.423,698,0.729,"bis.maltolato.oxovanadium.IV., sodium.stibogluconate, mycophenolic.acid, AS.1949490, BVT.948, CID.5458317, alexidine, GSK2830371",0.373659632624958,0.137272471682025,FALSE +"H2009","Pearson.est","phosphodiesterase inhibitor",0.21912,0.647,0.9,148,0.929,"cilostamide, EMD.53998",0.0457574905606751,0.0319842860063582,FALSE +"H2009","Pearson.est","PI3K inhibitor",-0.42772,-1.04,0.419,730,0.729,"alpelisib, PF.05212384, PI.828, NVP.BEZ235, PKI.179, GDC.0980, TG100.115, YM.201636, voxtalisib, AZD6482, BGT226, TG.100713, PI3K.IN.2, LY303511, LY3023414, PF.04691502, GDC.0941, CUDC.907, GSK2126458, SB.2343, CH5132799",0.377785977033705,0.137272471682025,FALSE +"H2009","Pearson.est","PLK inhibitor",-0.25585,-0.622,0.9,694,0.939,"NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.0457574905606751,0.0273344077338891,FALSE +"H2009","Pearson.est","potassium channel blocker",0.3143,0.902,0.547,183,0.865,"dofetilide, mepivacaine",0.262012673666569,0.0629838925351858,FALSE +"H2009","Pearson.est","PPAR receptor agonist",-0.42145,-1.02,0.434,1265,0.71,"pterostilbene",0.362510270487489,0.148741651280925,FALSE +"H2009","Pearson.est","progesterone receptor agonist",-0.37147,-0.9,0.586,1340,0.771,"melengestrol.acetate, danazol",0.232102383981909,0.112945621949043,FALSE +"H2009","Pearson.est","proteasome inhibitor",0.29527,0.856,0.602,156,0.846,"MG.132, carfilzomib",0.220403508742175,0.0726296369609765,FALSE +"H2009","Pearson.est","protein synthesis inhibitor",0.24995,0.712,0.844,288,0.994,"clofoctol, cycloheximide, homoharringtonine, chloramphenicol.palmitate, bruceantin, methacycline, anguidine, emetine",0.073657553374345,0.00261361560268669,FALSE +"H2009","Pearson.est","protein tyrosine kinase inhibitor",-0.38497,-0.926,0.561,914,0.794,"tyrphostin.A9, NVP.TAE226, mubritinib, BMS.599626",0.251037138743839,0.100179497572904,FALSE +"H2009","Pearson.est","RAF inhibitor",-0.30464,-0.738,0.782,1345,0.85,"sorafenib, TAK.632",0.106793246940152,0.0705810742857073,FALSE +"H2009","Pearson.est","RET tyrosine kinase inhibitor",-0.38129,-0.915,0.594,1126,0.778,"cabozantinib, sunitinib, sorafenib",0.226213555018806,0.109020403010311,FALSE +"H2009","Pearson.est","retinoid receptor agonist",-0.61883,-1.49,0.0612,1285,0.557,"adapalene, fenretinide, bexarotene",1.21324857785444,0.254144804826271,FALSE +"H2009","Pearson.est","ribonucleotide reductase inhibitor",-0.38373,-0.939,0.538,1008,0.809,"clofarabine, fludarabine, cladribine, pentostatin",0.269217724333611,0.0920514783877277,FALSE +"H2009","Pearson.est","serotonin receptor agonist",-0.56269,-1.35,0.135,920,0.668,"NAN.190, zolmitriptan, ipsapirone, aripiprazole",0.869666231504994,0.175223537524454,FALSE +"H2009","Pearson.est","serotonin receptor antagonist",-0.52625,-1.28,0.19,1391,0.554,"lurasidone, aripiprazole",0.721246399047171,0.25649023527157,FALSE +"H2009","Pearson.est","sodium channel blocker",-0.47074,-1.15,0.296,1243,0.692,"quinidine, triamterene, ajmaline, lappaconite",0.528708288941061,0.159893905543242,FALSE +"H2009","Pearson.est","src inhibitor",0.36716,1.02,0.388,20,0.88,"dasatinib, saracatinib",0.411168274405793,0.0555173278498314,FALSE +"H2009","Pearson.est","sterol demethylase inhibitor",-0.51326,-1.25,0.208,1000,0.542,"terconazole, ketoconazole",0.681936665037238,0.266000713461613,FALSE +"H2009","Pearson.est","TGF beta receptor inhibitor",-0.33625,-0.811,0.706,1356,0.845,"adaprev",0.151195298948196,0.0731432910503077,FALSE +"H2009","Pearson.est","thymidylate synthase inhibitor",0.33864,0.938,0.465,258,0.92,"capecitabine, doxifluridine, ftorafur",0.332547047110046,0.0362121726544447,FALSE +"H2009","Pearson.est","topoisomerase inhibitor",-0.37367,-0.906,0.589,891,0.777,"valrubicin, voreloxin, camptothecin, topotecan, nemorubicin, etoposide.phosphate, SN.38, TAS.103, fleroxacin, rubitecan, dexrazoxane, genz.644282, irinotecan",0.229884705212898,0.109578981199086,FALSE +"H2009","Pearson.est","tubulin polymerization inhibitor",0.19821,0.576,0.952,278,0.947,"mebendazole, CYT.997, BNC105, paclitaxel, vincristine, vindesine, epothilone.b",0.0213630516155257,0.0236500209967266,FALSE +"H2009","Pearson.est","tyrosine kinase inhibitor",-0.31367,-0.769,0.768,1090,0.855,"NVP.TAE226, mubritinib, cabozantinib, sunitinib, GTP.14564, BMS.599626, sorafenib, UNC2250",0.114638779968488,0.0680338852718274,FALSE +"H2009","Pearson.est","VEGFR inhibitor",-0.35663,-0.868,0.622,1085,0.791,"RAF265, axitinib, PD.173074, linifanib, cabozantinib, sunitinib, lenvatinib, MK.2461, ENMD.2076, tivozanib, sorafenib, MGCD.265, lucitanib, KI.8751",0.206209615309181,0.101823516502323,FALSE +"H2009","Pearson.est","vitamin D receptor agonist",-0.59065,-1.45,0.0788,1286,0.541,"maxacalcitol, paricalcitol, tacalcitol",1.10347378251044,0.266802734893431,FALSE +"HCC4006","Pearson.est","EGFR inhibitor",0.31362,0.918,0.557,77,0.854,"pelitinib, vandetanib, canertinib, brigatinib, erlotinib, rociletinib, BMS.690514, XL.647, afatinib",0.254144804826271,0.068542129310995,FALSE +"HCC4006","Pearson.est","Abl kinase inhibitor",-0.54753,-1.32,0.145,1074,0.577,"metatinib, flumatinib, nilotinib, KW.2449, imatinib, ponatinib, tozasertib",0.838631997765025,0.238824186844269,FALSE +"HCC4006","Pearson.est","acetylcholine receptor agonist",-0.40891,-0.981,0.495,959,0.846,"xanomeline, nicotine, nefiracetam, pilocarpine",0.305394801066431,0.0726296369609765,FALSE +"HCC4006","Pearson.est","acetylcholine receptor antagonist",-0.4195,-1.01,0.444,670,0.832,"darifenacin, diphemanil, dicycloverine, methscopolamine, iododexetimide",0.35261702988538,0.0798766737092761,FALSE +"HCC4006","Pearson.est","adenosine receptor antagonist",-0.62184,-1.52,0.0497,1229,0.462,"MRS.1220, CGS.15943, SCH.58261",1.30364361126667,0.335358024443874,FALSE +"HCC4006","Pearson.est","adrenergic receptor agonist",-0.37382,-0.921,0.56,1036,0.882,"A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.2518119729938,0.0545314148681803,FALSE +"HCC4006","Pearson.est","adrenergic receptor antagonist",0.39999,1.22,0.224,252,0.649,"prazosin, vincamine, RS.17053, imiloxan, atenolol...., practolol, levobunolol, dihydroergocristine, idazoxan",0.649751981665837,0.187755303199631,FALSE +"HCC4006","Pearson.est","AKT inhibitor",-0.5334,-1.29,0.173,1053,0.556,"GDC.0068, triciribine, ONC201, uprosertib, CCT128930, A.674563",0.761953896871205,0.254925208417942,FALSE +"HCC4006","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27703,-0.681,0.868,890,0.918,"CEP.37440, NVP.TAE684, AZD3463, AP26113, alectinib, DMH1",0.0614802748235081,0.0371573187987575,FALSE +"HCC4006","Pearson.est","androgen receptor antagonist",-0.55423,-1.33,0.147,909,0.587,"nilutamide, flutamide, bicalutamide",0.832682665251824,0.231361898752386,FALSE +"HCC4006","Pearson.est","antioxidant",-0.46971,-1.14,0.292,1296,0.653,"benfotiamine, trolox",0.534617148551582,0.185086818724926,FALSE +"HCC4006","Pearson.est","AP inhibitor",0.57911,1.67,0.0258,32,0.474,"GDC.0152, birinapant",1.58838029403677,0.324221658325915,FALSE +"HCC4006","Pearson.est","ATPase inhibitor",0.30218,0.872,0.586,138,0.891,"k.strophanthidin, digitoxin, ouabain",0.232102383981909,0.0501222959631252,FALSE +"HCC4006","Pearson.est","Aurora kinase inhibitor",-0.64017,-1.54,0.0477,1200,0.72,"CCT129202, KW.2449, barasertib.HQPA, AMG900, ENMD.2076, SNS.314, aurora.a.inhibitor.i, PF.03814735, MK.8745, AT.9283, barasertib, hesperadin, tozasertib",1.32148162095989,0.142667503568732,FALSE +"HCC4006","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.53029,-1.28,0.181,886,0.55,"valnemulin, azalomycin.b, josamycin, tilmicosin, radezolid, dirithromycin",0.742321425130815,0.259637310505756,FALSE +"HCC4006","Pearson.est","bacterial DNA gyrase inhibitor",0.53241,1.56,0.0957,235,0.48,"sarafloxacin, finafloxacin, novobiocin, sparfloxacin",1.01908806222316,0.318758762624413,FALSE +"HCC4006","Pearson.est","BCL inhibitor",-0.54705,-1.33,0.145,1166,0.587,"gossypol, ABT.737",0.838631997765025,0.231361898752386,FALSE +"HCC4006","Pearson.est","Bcr.Abl kinase inhibitor",-0.53114,-1.3,0.159,1074,0.56,"metatinib, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.798602875679548,0.2518119729938,FALSE +"HCC4006","Pearson.est","benzodiazepine receptor agonist",0.21624,0.611,0.933,46,0.969,"ZK.93423, gamma.aminobutyric.acid",0.0301183562535,0.0136762229492347,FALSE +"HCC4006","Pearson.est","bromodomain inhibitor",-0.68154,-1.67,0.0214,1007,1,"OTX015, PFI.1, JQ1...., bromosporine, I.BET151",1.66958622665081,0,FALSE +"HCC4006","Pearson.est","calcium channel blocker",-0.63627,-1.53,0.0526,1251,0.508,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.27901425584626,0.294136287716081,FALSE +"HCC4006","Pearson.est","CC chemokine receptor antagonist",-0.46332,-1.13,0.319,1002,0.653,"SB.225002, PF.04136309, navarixin",0.496209316942819,0.185086818724926,FALSE +"HCC4006","Pearson.est","CDK inhibitor",-0.47845,-1.16,0.276,996,0.677,"palbociclib, AZD5438, BMS.265246, NU6027, JNJ.7706621, indisulam, kenpaullone, abemaciclib, ribociclib, indirubin, R547, arcyriaflavin.a",0.559090917934782,0.169411331314856,FALSE +"HCC4006","Pearson.est","CHK inhibitor",0.51032,1.45,0.0882,209,0.427,"SCH.900776, CHIR.124, LY2603618, LY2606368",1.05453141486818,0.369572124974976,FALSE +"HCC4006","Pearson.est","cyclooxygenase inhibitor",-0.34444,-0.828,0.706,970,0.791,"curcumin, tepoxalin, metoxibutropate, indoprofen, FK.3311, piroxicam, naproxen, aspirin, pterostilbene, FR.122047, tryptanthrin",0.151195298948196,0.101823516502323,FALSE +"HCC4006","Pearson.est","cytochrome P450 inhibitor",0.34402,1.01,0.382,289,0.716,"PF.4981517, morin, eplerenone, metyrapone",0.417936637088291,0.145086977692144,FALSE +"HCC4006","Pearson.est","DNA alkylating agent",-0.36436,-0.877,0.627,918,0.845,"carmustine, carboplatin, temozolomide, ifosfamide, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.202732459169284,0.0731432910503077,FALSE +"HCC4006","Pearson.est","DNA inhibitor",-0.3881,-0.946,0.54,918,0.877,"carmustine, carboplatin, valrubicin, tirapazamine, pibenzimol, metronidazole, melphalan, primaquine, mechlorethamine",0.267606240177031,0.0570004066339595,FALSE +"HCC4006","Pearson.est","DNA methyltransferase inhibitor",-0.37963,-0.91,0.577,1030,0.841,"fdcyd, disulfiram, RG108",0.238824186844269,0.0752040042020878,FALSE +"HCC4006","Pearson.est","DNA polymerase inhibitor",0.25486,0.722,0.793,1081,0.89,"cephalomannine, famciclovir, menadione, adefovir.dipivoxil, idoxuridine, trifluridine, foscarnet, cidofovir",0.100726812682396,0.0506099933550872,FALSE +"HCC4006","Pearson.est","DNA synthesis inhibitor",-0.35257,-0.85,0.666,833,0.821,"cisplatin, anisomycin, artesunate, azodicarbonamide, estramustine.phosphate, altretamine, CB.10.277, enocitabine, mitomycin.c",0.176525770829699,0.0856568428805592,FALSE +"HCC4006","Pearson.est","dopamine receptor antagonist",-0.36829,-0.91,0.587,1100,0.841,"paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.231361898752386,0.0752040042020878,FALSE +"HCC4006","Pearson.est","estrogen receptor agonist",0.49076,1.46,0.1,31,0.514,"PPT, levonorgestrel",1,0.289036881004724,FALSE +"HCC4006","Pearson.est","estrogen receptor antagonist",-0.68093,-1.65,0.0196,1262,0.676,"toremifene, danazol, fulvestrant",1.70774392864352,0.170053304058364,FALSE +"HCC4006","Pearson.est","FGFR inhibitor",-0.59068,-1.45,0.081,1171,0.439,"PD.173074, MK.2461, erdafitinib, lenvatinib, lucitanib",1.09151498112135,0.357535479757879,FALSE +"HCC4006","Pearson.est","FLT3 inhibitor",-0.57714,-1.4,0.106,1127,0.522,"sunitinib, tandutinib, KW.2449, GTP.14564, TG.101348, ENMD.2076, sorafenib, ponatinib, quizartinib, tozasertib",0.97469413473523,0.282329496997738,FALSE +"HCC4006","Pearson.est","glucocorticoid receptor agonist",0.4117,1.2,0.256,290,0.604,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, fluocinolone.acetonide, ciclesonide, prednisolone, halcinonide, triamcinolone.acetonide, fludroxycortide, desonide",0.59176003468815,0.218963061378868,FALSE +"HCC4006","Pearson.est","glutamate receptor antagonist",0.28657,0.819,0.682,132,0.826,"SIB.1757, latrepirdine, kynurenic.acid",0.166215625343521,0.0830199526796178,FALSE +"HCC4006","Pearson.est","glycogen synthase kinase inhibitor",-0.49768,-1.22,0.226,1175,0.637,"kenpaullone, LY2090314, GSK.3.inhibitor.IX, indirubin, CHIR.98014",0.645891560852599,0.19586056766465,FALSE +"HCC4006","Pearson.est","growth factor receptor inhibitor",-0.50215,-1.19,0.264,863,0.656,"GSK1904529A, lestaurtinib, AZD3463, GSK1838705A, GW.441756",0.578396073130169,0.18309616062434,FALSE +"HCC4006","Pearson.est","HCV inhibitor",0.26808,0.806,0.694,58,0.8,"daclatasvir",0.158640529545145,0.0969100130080564,FALSE +"HCC4006","Pearson.est","HDAC inhibitor",-0.54329,-1.31,0.166,1049,0.567,"entinostat, PCI.24781, scriptaid, dacinostat, panobinostat, AR.42, trichostatin.a, vorinostat, givinostat, RG2833, resminostat, M.344, R306465, RGFP966",0.779891911959945,0.246416941107093,FALSE +"HCC4006","Pearson.est","histamine receptor antagonist",-0.24261,-0.593,0.931,1095,0.946,"lafutidine, BF2.649, tecastemizole, epinastine",0.0310503190186574,0.0241088635982073,FALSE +"HCC4006","Pearson.est","HMGCR inhibitor",-0.25749,-0.624,0.924,1006,0.939,"fluvastatin, lovastatin",0.0343280287798933,0.0273344077338891,FALSE +"HCC4006","Pearson.est","HSP inhibitor",0.44405,1.29,0.16,323,0.602,"BIIB021, KW.2478, SNX.5422, SNX.2112, alvespimycin, NVP.AUY922, ganetespib, VER.49009",0.795880017344075,0.220403508742175,FALSE +"HCC4006","Pearson.est","JAK inhibitor",-0.35878,-0.869,0.641,810,0.823,"WHI.P154, TG.02, CEP.33779, lestaurtinib, LY2784544, pacritinib, AZD1480, TG.101348, AT.9283, TG.101209, tozasertib",0.193141970481183,0.0846001647877302,FALSE +"HCC4006","Pearson.est","KIT inhibitor",-0.44242,-1.07,0.367,1127,0.741,"sunitinib, tandutinib, imatinib, lenvatinib, sorafenib, KI.8751, masitinib",0.435333935747911,0.130181792020672,FALSE +"HCC4006","Pearson.est","MDM inhibitor",-0.48485,-1.16,0.296,1123,0.677,"serdemetan, RITA",0.528708288941061,0.169411331314856,FALSE +"HCC4006","Pearson.est","MEK inhibitor",0.63054,1.88,0.0142,177,0.416,"selumetinib, AS.703026, trametinib, Ro.4987655, MEK1.2.inhibitor, cobimetinib, AZD8330, TAK.733, PD.198306, PD.0325901",1.84771165561694,0.380906669373257,FALSE +"HCC4006","Pearson.est","MET inhibitor",-0.61123,-1.46,0.0599,1394,0.568,"NVP.BVU972, AMG458",1.22257317761069,0.245651664288981,FALSE +"HCC4006","Pearson.est","microtubule inhibitor",-0.20263,-0.481,0.983,773,0.984,"cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.00744648216786438,0.00700490156865849,FALSE +"HCC4006","Pearson.est","mTOR inhibitor",-0.47602,-1.14,0.303,817,0.653,"NVP.BEZ235, AZD8055, temsirolimus, deforolimus, voxtalisib, OSI.027, PF.05212384, PKI.179, torin.2, MLN0128, sirolimus, LY303511, XL388, torin.1, LY3023414, PF.04691502, ku.0063794, GSK2126458, WYE.354, AZD2014, SB.2343",0.518557371497695,0.185086818724926,FALSE +"HCC4006","Pearson.est","NFkB pathway inhibitor",-0.35071,-0.854,0.653,1323,0.831,"EVP4593, betulinic.acid",0.185086818724926,0.080398976215889,FALSE +"HCC4006","Pearson.est","opioid receptor agonist",-0.36522,-0.873,0.609,738,0.833,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.215382707367125,0.0793549985932124,FALSE +"HCC4006","Pearson.est","p38 MAPK inhibitor",-0.46799,-1.15,0.29,1340,0.677,"SB.239063, skepinone.l",0.537602002101044,0.169411331314856,FALSE +"HCC4006","Pearson.est","PARP inhibitor",-0.63686,-1.53,0.0449,1189,0.508,"AG.14361, PJ.34, E7449, niraparib",1.34775365899668,0.294136287716081,FALSE +"HCC4006","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49434,-1.19,0.242,1103,0.656,"crenolanib, sunitinib, linifanib, axitinib, tandutinib, imatinib, lenvatinib, sorafenib, ponatinib, KI.8751, masitinib",0.616184634019569,0.18309616062434,FALSE +"HCC4006","Pearson.est","phosphatase inhibitor",-0.43859,-1.07,0.367,840,0.741,"AS.1949490, sodium.stibogluconate, BVT.948, CID.5458317, alexidine, GSK2830371",0.435333935747911,0.130181792020672,FALSE +"HCC4006","Pearson.est","phosphodiesterase inhibitor",0.29624,0.846,0.633,1022,0.88,"cilostamide, EMD.53998, anagrelide, enoximone, avanafil, papaverine, trequinsin, zardaverine, GSK256066, YM.976",0.198596289982645,0.0555173278498314,FALSE +"HCC4006","Pearson.est","PI3K inhibitor",-0.41176,-0.985,0.483,871,0.861,"voxtalisib, PF.05212384, YM.201636, PKI.179, PI3K.IN.2, AZD6482, TG.100713, BGT226, LY303511, LY3023414, PF.04691502, GDC.0941, GSK2126458, CUDC.907, CH5132799, SB.2343",0.316052869248488,0.0649968485463452,FALSE +"HCC4006","Pearson.est","PLK inhibitor",-0.34936,-0.836,0.669,787,0.81,"BI.2536, NMS.1286937, volasertib, rigosertib, GW.843682X",0.174573882232177,0.0915149811213502,FALSE +"HCC4006","Pearson.est","potassium channel blocker",0.27925,0.822,0.665,167,0.872,"dofetilide, mepivacaine",0.177178354696895,0.0594835150674328,FALSE +"HCC4006","Pearson.est","PPAR receptor agonist",-0.37953,-0.929,0.56,1298,0.888,"pterostilbene",0.2518119729938,0.051587034221399,FALSE +"HCC4006","Pearson.est","progesterone receptor agonist",-0.34099,-0.835,0.689,1322,0.796,"melengestrol.acetate, danazol",0.161780778092374,0.0990869322623309,FALSE +"HCC4006","Pearson.est","proteasome inhibitor",0.38436,1.09,0.33,117,0.678,"MG.132, carfilzomib",0.481486060122112,0.168770306132937,FALSE +"HCC4006","Pearson.est","protein synthesis inhibitor",-0.29786,-0.729,0.804,1268,0.879,"thiostrepton, florfenicol, azomycin..2.nitroimidazole.",0.0947439512515487,0.0560111249262281,FALSE +"HCC4006","Pearson.est","protein tyrosine kinase inhibitor",-0.37837,-0.918,0.583,1092,0.866,"NVP.TAE226, mubritinib, BMS.599626",0.234331445240986,0.0624821079826534,FALSE +"HCC4006","Pearson.est","RAF inhibitor",-0.25243,-0.625,0.906,1293,0.954,"sorafenib, TAK.632",0.0428718023231869,0.0204516252959049,FALSE +"HCC4006","Pearson.est","RET tyrosine kinase inhibitor",-0.37109,-0.879,0.641,1127,0.86,"sunitinib, cabozantinib, sorafenib",0.193141970481183,0.0655015487564323,FALSE +"HCC4006","Pearson.est","retinoid receptor agonist",-0.55568,-1.34,0.154,1254,0.646,"adapalene, fenretinide, bexarotene",0.812479279163537,0.189767482004916,FALSE +"HCC4006","Pearson.est","ribonucleotide reductase inhibitor",-0.31069,-0.756,0.776,804,0.861,"fludarabine, clofarabine, cytarabine, cladribine, pentostatin",0.110138278741812,0.0649968485463452,FALSE +"HCC4006","Pearson.est","serotonin receptor agonist",-0.59799,-1.45,0.0708,1275,0.439,"ipsapirone, aripiprazole",1.14996674231023,0.357535479757879,FALSE +"HCC4006","Pearson.est","serotonin receptor antagonist",-0.514,-1.22,0.216,1382,0.637,"lurasidone, aripiprazole",0.665546248849069,0.19586056766465,FALSE +"HCC4006","Pearson.est","sodium channel blocker",-0.42123,-1.03,0.429,906,0.811,"oxcarbazepine, cibenzoline, A.803467, triamterene, quinidine, ajmaline, lappaconite",0.367542707815276,0.090979145788844,FALSE +"HCC4006","Pearson.est","src inhibitor",0.35834,1.05,0.352,19,0.697,"dasatinib, saracatinib",0.453457336521869,0.156767221901991,FALSE +"HCC4006","Pearson.est","sterol demethylase inhibitor",-0.65288,-1.61,0.0352,1099,0.598,"terconazole, ketoconazole",1.45345733652187,0.223298816011589,FALSE +"HCC4006","Pearson.est","TGF beta receptor inhibitor",-0.39388,-0.952,0.542,1385,0.887,"adaprev",0.266000713461613,0.0520763801682736,FALSE +"HCC4006","Pearson.est","thymidylate synthase inhibitor",0.4026,1.18,0.244,218,0.569,"capecitabine, doxifluridine, ftorafur",0.612610173661271,0.244887733604929,FALSE +"HCC4006","Pearson.est","topoisomerase inhibitor",-0.35465,-0.845,0.68,900,0.813,"etoposide.phosphate, voreloxin, valrubicin, camptothecin, nemorubicin, rubitecan, fleroxacin, SN.38, dexrazoxane, TAS.103, genz.644282, irinotecan",0.167491087293764,0.0899094544059319,FALSE +"HCC4006","Pearson.est","tubulin polymerization inhibitor",0.14697,0.433,1,236,0.996,"mebendazole, CYT.997, BNC105, paclitaxel, vindesine",0,0.00174066157630127,FALSE +"HCC4006","Pearson.est","tyrosine kinase inhibitor",-0.30598,-0.758,0.77,1092,0.874,"NVP.TAE226, sunitinib, mubritinib, cabozantinib, BMS.599626, GTP.14564, sorafenib, UNC2250",0.113509274827518,0.058488567365597,FALSE +"HCC4006","Pearson.est","VEGFR inhibitor",-0.36819,-0.892,0.618,1127,0.856,"sunitinib, linifanib, axitinib, cabozantinib, PD.173074, MK.2461, ENMD.2076, lenvatinib, sorafenib, MGCD.265, tivozanib, lucitanib, KI.8751",0.209011524911184,0.0675262353228468,FALSE +"HCC4006","Pearson.est","vitamin D receptor agonist",-0.61241,-1.45,0.0765,1288,0.439,"paricalcitol, maxacalcitol, tacalcitol",1.11633856484638,0.357535479757879,FALSE +"HCC2279","Pearson.est","EGFR inhibitor",0.42545,1.18,0.247,173,0.525,"pelitinib, canertinib, vandetanib, rociletinib, XL.647, afatinib, brigatinib, erlotinib, BMS.690514, CUDC.101, dacomitinib, neratinib, AZD8931, lapatinib",0.607303046740334,0.279840696594043,FALSE +"HCC2279","Pearson.est","Abl kinase inhibitor",-0.51902,-1.26,0.2,1034,0.782,"metatinib, KW.2449, imatinib, nilotinib, flumatinib, ponatinib, tozasertib",0.698970004336019,0.106793246940152,FALSE +"HCC2279","Pearson.est","acetylcholine receptor agonist",-0.47252,-1.13,0.339,1190,0.804,"nicotine, nefiracetam, pilocarpine",0.469800301796918,0.0947439512515487,FALSE +"HCC2279","Pearson.est","acetylcholine receptor antagonist",-0.50208,-1.2,0.26,724,0.731,"hyoscyamine, darifenacin, diphemanil, dicycloverine, iododexetimide, methscopolamine",0.585026652029182,0.13608262304214,FALSE +"HCC2279","Pearson.est","adenosine receptor antagonist",-0.5157,-1.27,0.173,875,0.805,"sulmazole, istradefylline, CGS.15943, MRS.1220, SCH.58261",0.761953896871205,0.0942041196321315,FALSE +"HCC2279","Pearson.est","adrenergic receptor agonist",-0.46039,-1.1,0.353,1011,0.811,"ritodrine, A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.452225294612177,0.090979145788844,FALSE +"HCC2279","Pearson.est","adrenergic receptor antagonist",0.45082,1.26,0.181,186,0.545,"prazosin, vincamine, RS.17053, practolol, levobunolol, dihydroergocristine, idazoxan",0.742321425130815,0.263603497723358,FALSE +"HCC2279","Pearson.est","AKT inhibitor",-0.34255,-0.832,0.675,971,0.864,"uprosertib, ONC201, A.674563, CCT128930",0.170696227168975,0.0634862575211067,FALSE +"HCC2279","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.3131,-0.754,0.767,1209,0.909,"alectinib, AP26113, DMH1",0.115204636051019,0.0414361167780325,FALSE +"HCC2279","Pearson.est","androgen receptor antagonist",-0.69017,-1.68,0.0255,1148,0.402,"nilutamide, flutamide, bicalutamide",1.59345981956604,0.39577394691553,FALSE +"HCC2279","Pearson.est","antioxidant",-0.53854,-1.32,0.16,1357,0.767,"benfotiamine, trolox",0.795880017344075,0.115204636051019,FALSE +"HCC2279","Pearson.est","AP inhibitor",0.58129,1.65,0.0528,59,0.438,"birinapant, GDC.0152",1.27736607746619,0.3585258894959,FALSE +"HCC2279","Pearson.est","ATPase inhibitor",0.29322,0.803,0.662,221,0.899,"k.strophanthidin, blebbistatin...., digitoxin",0.1791420105603,0.0462403082667712,FALSE +"HCC2279","Pearson.est","Aurora kinase inhibitor",-0.49231,-1.21,0.224,1022,0.785,"AMG900, SNS.314, AT.9283, KW.2449, ENMD.2076, aurora.a.inhibitor.i, MK.8745, CCT129202, PF.03814735, barasertib, hesperadin, tozasertib",0.649751981665837,0.105130343254747,FALSE +"HCC2279","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.53932,-1.32,0.156,1082,0.767,"josamycin, tilmicosin, radezolid, dirithromycin",0.806875401645538,0.115204636051019,FALSE +"HCC2279","Pearson.est","bacterial DNA gyrase inhibitor",0.49883,1.36,0.148,223,0.507,"novobiocin, finafloxacin, sarafloxacin",0.829738284605043,0.294992040666664,FALSE +"HCC2279","Pearson.est","BCL inhibitor",-0.33794,-0.828,0.658,1360,0.852,"ABT.737",0.181774106386044,0.0695604052332999,FALSE +"HCC2279","Pearson.est","Bcr.Abl kinase inhibitor",-0.53641,-1.3,0.188,1184,0.769,"imatinib, nilotinib, flumatinib, ponatinib, tozasertib",0.72584215073632,0.114073660198569,FALSE +"HCC2279","Pearson.est","benzodiazepine receptor agonist",-0.20827,-0.501,0.978,801,0.994,"CL.218872, ivermectin, bentazepam, piperazine, indiplon, temazepam, nefiracetam, lorazepam",0.00966114521239857,0.00261361560268669,FALSE +"HCC2279","Pearson.est","bromodomain inhibitor",-0.38403,-0.951,0.518,862,0.815,"JQ1...., PFI.1, I.BET151, bromosporine",0.285670240254767,0.0888423912600234,FALSE +"HCC2279","Pearson.est","calcium channel blocker",-0.44446,-1.08,0.351,1283,0.769,"carboxyamidotriazole, cinnarazine, SR.33805",0.454692883534176,0.114073660198569,FALSE +"HCC2279","Pearson.est","CC chemokine receptor antagonist",-0.36518,-0.891,0.593,1141,0.803,"PF.04136309, navarixin",0.226945306635737,0.095284454721319,FALSE +"HCC2279","Pearson.est","CDK inhibitor",-0.23354,-0.562,0.951,1352,1,"R547, indirubin, arcyriaflavin.a",0.0218194830625861,0,FALSE +"HCC2279","Pearson.est","CHK inhibitor",0.52066,1.43,0.119,97,0.563,"SCH.900776, CHIR.124, LY2603618",0.924453038607469,0.249491605148654,FALSE +"HCC2279","Pearson.est","cyclooxygenase inhibitor",-0.32507,-0.803,0.697,1026,0.855,"tepoxalin, FK.3311, indoprofen, piroxicam, metoxibutropate, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.156767221901991,0.0680338852718274,FALSE +"HCC2279","Pearson.est","cytochrome P450 inhibitor",-0.25665,-0.63,0.896,1345,0.982,"clotrimazole",0.0476919903378748,0.00788851221305034,FALSE +"HCC2279","Pearson.est","DNA alkylating agent",-0.37959,-0.922,0.555,1075,0.826,"cyclophosphamide, carmustine, temozolomide, carboplatin, melphalan, satraplatin, mitomycin.c",0.255707016877324,0.0830199526796178,FALSE +"HCC2279","Pearson.est","DNA inhibitor",-0.41766,-1.02,0.436,1040,0.793,"pibenzimol, primaquine, carmustine, carboplatin, melphalan, metronidazole, tirapazamine, mechlorethamine",0.360513510731414,0.100726812682396,FALSE +"HCC2279","Pearson.est","DNA methyltransferase inhibitor",0.43956,1.2,0.262,183,0.538,"decitabine, SGI.1027, azacitidine",0.581698708680255,0.269217724333611,FALSE +"HCC2279","Pearson.est","DNA polymerase inhibitor",0.31319,0.875,0.568,997,0.81,"cephalomannine, menadione, idoxuridine, adefovir.dipivoxil, famciclovir, trifluridine, cidofovir, foscarnet",0.245651664288981,0.0915149811213502,FALSE +"HCC2279","Pearson.est","DNA synthesis inhibitor",-0.38809,-0.94,0.529,840,0.813,"cisplatin, azodicarbonamide, artesunate, nelarabine, estramustine.phosphate, enocitabine, altretamine, CB.10.277, mitomycin.c",0.276544327964814,0.0899094544059319,FALSE +"HCC2279","Pearson.est","dopamine receptor antagonist",-0.41313,-0.99,0.467,784,0.784,"ziprasidone, clebopride, oxiperomide, raclopride, domperidone, amisulpride, paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.330683119433888,0.105683937315562,FALSE +"HCC2279","Pearson.est","estrogen receptor agonist",0.45787,1.22,0.238,37,0.556,"PPT, levonorgestrel",0.623423042943488,0.254925208417942,FALSE +"HCC2279","Pearson.est","estrogen receptor antagonist",-0.76464,-1.85,0.00576,1286,0.287,"toremifene, fulvestrant, danazol",2.23957751657679,0.542118103266008,FALSE +"HCC2279","Pearson.est","FGFR inhibitor",-0.70487,-1.75,0.0146,1119,0.361,"orantinib, PD.173074, lucitanib, lenvatinib, erdafitinib, MK.2461",1.83564714421556,0.442492798094342,FALSE +"HCC2279","Pearson.est","FLT3 inhibitor",-0.60535,-1.47,0.0813,998,0.904,"sorafenib, sunitinib, KW.2449, ENMD.2076, midostaurin, TG.101348, tandutinib, GTP.14564, quizartinib, ponatinib, tozasertib",1.08990945440593,0.0438315695246367,FALSE +"HCC2279","Pearson.est","glucocorticoid receptor agonist",0.41621,1.14,0.273,317,0.545,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, prednisolone, fludroxycortide, halcinonide, triamcinolone.acetonide, fluocinolone.acetonide, desonide",0.563837352959244,0.263603497723358,FALSE +"HCC2279","Pearson.est","glutamate receptor antagonist",-0.28599,-0.674,0.859,1312,0.955,"MTPG, IEM1754",0.0660068361687577,0.0199966284162537,FALSE +"HCC2279","Pearson.est","glycogen synthase kinase inhibitor",-0.49341,-1.21,0.24,1257,0.785,"GSK.3.inhibitor.IX, LY2090314, indirubin, CHIR.98014",0.619788758288394,0.105130343254747,FALSE +"HCC2279","Pearson.est","growth factor receptor inhibitor",-0.41168,-1,0.455,741,0.811,"AZD3463, lestaurtinib, GSK1904529A, GSK1838705A, GW.441756",0.341988603342888,0.090979145788844,FALSE +"HCC2279","Pearson.est","HCV inhibitor",0.29815,0.795,0.691,98,0.868,"daclatasvir",0.160521952625802,0.0614802748235081,FALSE +"HCC2279","Pearson.est","HDAC inhibitor",-0.42237,-1.03,0.412,1098,0.823,"panobinostat, trichostatin.a, givinostat, vorinostat, M.344, R306465, resminostat, RG2833, RGFP966",0.385102783966865,0.0846001647877302,FALSE +"HCC2279","Pearson.est","histamine receptor antagonist",-0.37141,-0.895,0.597,1205,0.815,"BF2.649, lafutidine, tecastemizole, epinastine",0.224025668870631,0.0888423912600234,FALSE +"HCC2279","Pearson.est","HMGCR inhibitor",-0.59718,-1.44,0.069,1304,0.757,"lovastatin, fluvastatin",1.16115090926274,0.120904120499927,FALSE +"HCC2279","Pearson.est","HSP inhibitor",0.63349,1.68,0.0764,269,0.591,"BIIB021, KW.2478, alvespimycin, SNX.5422, SNX.2112, NVP.AUY922, ganetespib, VER.49009",1.11690664142431,0.228412519118745,FALSE +"HCC2279","Pearson.est","JAK inhibitor",-0.29219,-0.715,0.811,904,0.944,"LY2784544, CEP.33779, AT.9283, AZD1480, TG.101348, TG.101209, tozasertib",0.090979145788844,0.025028005701931,FALSE +"HCC2279","Pearson.est","KIT inhibitor",-0.44123,-1.07,0.378,1182,0.764,"midostaurin, imatinib, tandutinib, lenvatinib, KI.8751, masitinib",0.422508200162775,0.11690664142431,FALSE +"HCC2279","Pearson.est","MDM inhibitor",-0.44998,-1.09,0.361,1383,0.804,"RITA",0.442492798094342,0.0947439512515487,FALSE +"HCC2279","Pearson.est","MEK inhibitor",0.65343,1.86,0.0505,198,0.532,"trametinib, selumetinib, AS.703026, Ro.4987655, cobimetinib, AZD8330, MEK1.2.inhibitor, TAK.733, PD.198306, PD.0325901",1.29670862188134,0.274088367704952,FALSE +"HCC2279","Pearson.est","MET inhibitor",-0.66907,-1.6,0.0392,1420,0.525,"NVP.BVU972, AMG458",1.40671393297954,0.279840696594043,FALSE +"HCC2279","Pearson.est","microtubule inhibitor",0.28517,0.788,0.719,348,0.838,"vinflunine, secnidazole, triclabendazole, podophyllotoxin, vinblastine",0.143271109617117,0.0767559813697235,FALSE +"HCC2279","Pearson.est","mTOR inhibitor",-0.40617,-0.995,0.458,1054,0.797,"GSK2126458, sirolimus, LY303511, torin.1, LY3023414, PF.04691502, AZD2014, ku.0063794, WYE.354, SB.2343",0.339134521996131,0.0985416786038876,FALSE +"HCC2279","Pearson.est","NFkB pathway inhibitor",-0.19003,-0.467,0.989,748,0.988,"BAY.11.7085, bortezomib, curcumin, parthenolide, bindarit, EVP4593, betulinic.acid",0.0048037084028206,0.00524305541237188,FALSE +"HCC2279","Pearson.est","opioid receptor agonist",-0.4829,-1.17,0.29,914,0.77,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.537602002101044,0.113509274827518,FALSE +"HCC2279","Pearson.est","p38 MAPK inhibitor",-0.50718,-1.23,0.234,1162,0.821,"TAK.715, SB.239063, skepinone.l",0.630784142589857,0.0856568428805592,FALSE +"HCC2279","Pearson.est","PARP inhibitor",-0.56282,-1.4,0.102,1176,0.715,"niraparib, AG.14361, PJ.34, E7449",0.991399828238082,0.145693958198919,FALSE +"HCC2279","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.45892,-1.1,0.363,998,0.811,"sorafenib, crenolanib, sunitinib, axitinib, orantinib, imatinib, linifanib, tandutinib, lenvatinib, ponatinib, KI.8751, masitinib",0.440093374963888,0.090979145788844,FALSE +"HCC2279","Pearson.est","phosphatase inhibitor",-0.47707,-1.16,0.292,906,0.761,"AS.1949490, CID.5458317, bis.maltolato.oxovanadium.IV., sodium.stibogluconate, alexidine, GSK2830371, BVT.948",0.534617148551582,0.118615343229427,FALSE +"HCC2279","Pearson.est","phosphodiesterase inhibitor",0.21001,0.58,0.951,1146,0.983,"cilostamide, EMD.53998, avanafil, enoximone, anagrelide, papaverine, trequinsin, zardaverine, GSK256066, YM.976",0.0218194830625861,0.00744648216786438,FALSE +"HCC2279","Pearson.est","PI3K inhibitor",-0.37087,-0.904,0.584,730,0.819,"PI3K.IN.2, NVP.BEZ235, YM.201636, PKI.179, voxtalisib, pilaralisib, BGT226, TG.100713, PI.828, TG100.115, GSK2126458, LY303511, CUDC.907, AZD6482, LY3023414, PF.04691502, GDC.0941, CH5132799, SB.2343",0.233587152887601,0.0867160982395816,FALSE +"HCC2279","Pearson.est","PLK inhibitor",0.35253,0.974,0.441,940,0.758,"HMN.214, NMS.1286937, GSK461364, BI.2536, volasertib, rigosertib, GW.843682X",0.355561410532161,0.120330794367946,FALSE +"HCC2279","Pearson.est","potassium channel blocker",0.2205,0.601,0.93,319,1,"dofetilide, mepivacaine, oleoylethanolamide",0.0315170514460649,0,FALSE +"HCC2279","Pearson.est","PPAR receptor agonist",-0.36462,-0.873,0.602,1332,0.814,"pterostilbene",0.220403508742175,0.0893755951107988,FALSE +"HCC2279","Pearson.est","progesterone receptor agonist",-0.37478,-0.907,0.559,1319,0.834,"melengestrol.acetate, danazol",0.252588192113577,0.0788339493622613,FALSE +"HCC2279","Pearson.est","proteasome inhibitor",0.51432,1.42,0.118,71,0.485,"MG.132, carfilzomib",0.928117992693875,0.314258261397736,FALSE +"HCC2279","Pearson.est","protein synthesis inhibitor",0.40401,1.13,0.285,304,0.521,"homoharringtonine, bruceantin, anguidine, cycloheximide, clofoctol, chloramphenicol.palmitate, harringtonine, emetine, methacycline, puromycin",0.54515513999149,0.283162276700476,FALSE +"HCC2279","Pearson.est","protein tyrosine kinase inhibitor",-0.21701,-0.539,0.968,706,0.995,"PP.121, NVP.TAE226, rheochrysidin, mubritinib, BMS.599626",0.0141246426916063,0.00217691925427455,FALSE +"HCC2279","Pearson.est","RAF inhibitor",0.33747,0.96,0.46,115,0.739,"AZ.628, LGX818, vemurafenib",0.337242168318426,0.131355561605174,FALSE +"HCC2279","Pearson.est","RET tyrosine kinase inhibitor",0.32305,0.887,0.574,24,0.833,"vandetanib",0.241088107602027,0.0793549985932124,FALSE +"HCC2279","Pearson.est","retinoid receptor agonist",-0.44498,-1.08,0.353,1195,0.769,"fenretinide, adapalene, bexarotene",0.452225294612177,0.114073660198569,FALSE +"HCC2279","Pearson.est","ribonucleotide reductase inhibitor",-0.24254,-0.587,0.931,758,1,"clofarabine, hydroxyurea, fludarabine, cytarabine, cladribine, pentostatin",0.0310503190186574,0,FALSE +"HCC2279","Pearson.est","serotonin receptor agonist",-0.57977,-1.43,0.101,1316,0.695,"ipsapirone, aripiprazole",0.995678626217357,0.158015195409886,FALSE +"HCC2279","Pearson.est","serotonin receptor antagonist",-0.50347,-1.2,0.261,1361,0.731,"lurasidone, aripiprazole",0.583359492661719,0.13608262304214,FALSE +"HCC2279","Pearson.est","sodium channel blocker",-0.42177,-1.02,0.434,997,0.793,"cibenzoline, A.803467, oxcarbazepine, triamterene, ajmaline, quinidine, lappaconite",0.362510270487489,0.100726812682396,FALSE +"HCC2279","Pearson.est","src inhibitor",-0.342,-0.821,0.673,1443,0.844,"masitinib",0.171984935776023,0.073657553374345,FALSE +"HCC2279","Pearson.est","sterol demethylase inhibitor",-0.59683,-1.45,0.0763,1222,0.84,"terconazole, ketoconazole",1.11747546204512,0.0757207139381184,FALSE +"HCC2279","Pearson.est","TGF beta receptor inhibitor",-0.38818,-0.958,0.511,1391,0.823,"adaprev",0.291579099865287,0.0846001647877302,FALSE +"HCC2279","Pearson.est","thymidylate synthase inhibitor",0.55601,1.55,0.086,306,0.471,"capecitabine, doxifluridine, ftorafur, carmofur",1.06550154875643,0.326979092871104,FALSE +"HCC2279","Pearson.est","topoisomerase inhibitor",0.19146,0.53,0.965,232,0.971,"amsacrine, idarubicin, amonafide, etoposide, teniposide, epirubicin, mitoxantrone",0.0154726866562074,0.0127807700919951,FALSE +"HCC2279","Pearson.est","tubulin polymerization inhibitor",0.47588,1.34,0.152,352,0.475,"mebendazole, CYT.997, paclitaxel, vindesine, BNC105, vincristine, taltobulin, fosbretabulin, vinorelbine, epothilone.b, verubulin, fenbendazole, podophyllotoxin, dolastatin.10, vinblastine, oxibendazole",0.818156412055227,0.323306390375133,FALSE +"HCC2279","Pearson.est","tyrosine kinase inhibitor",0.21038,0.584,0.944,179,1,"vandetanib, dasatinib, AV.412, tivantinib, hypericin",0.025028005701931,0,FALSE +"HCC2279","Pearson.est","VEGFR inhibitor",-0.28007,-0.68,0.849,1064,0.967,"sunitinib, axitinib, ENMD.2076, cabozantinib, orantinib, PD.173074, linifanib, lucitanib, lenvatinib, MK.2461, MGCD.265, tivozanib, KI.8751",0.0710923097560473,0.0145735259169983,FALSE +"HCC2279","Pearson.est","vitamin D receptor agonist",-0.57276,-1.38,0.129,1196,0.705,"maxacalcitol, paricalcitol, tacalcitol",0.889410289700751,0.151810883008601,FALSE +"H520","Pearson.est","EGFR inhibitor",0.35524,1.06,0.366,59,0.6,"vandetanib, pelitinib, canertinib, brigatinib, XL.647, erlotinib, rociletinib, BMS.690514, afatinib",0.436518914605589,0.221848749616356,FALSE +"H520","Pearson.est","Abl kinase inhibitor",-0.46253,-1.13,0.306,1098,0.71,"ponatinib, KW.2449, flumatinib, nilotinib, imatinib, tozasertib",0.51427857351842,0.148741651280925,FALSE +"H520","Pearson.est","acetylcholine receptor agonist",-0.45822,-1.08,0.385,1008,0.804,"nicotine, xanomeline, nefiracetam, pilocarpine",0.414539270491499,0.0947439512515487,FALSE +"H520","Pearson.est","acetylcholine receptor antagonist",-0.42094,-1.02,0.454,607,0.823,"hyoscyamine, darifenacin, dicycloverine, diphemanil, methscopolamine, iododexetimide",0.342944147142896,0.0846001647877302,FALSE +"H520","Pearson.est","adenosine receptor antagonist",-0.54957,-1.33,0.14,1143,0.558,"CGS.15943, MRS.1220, SCH.58261",0.853871964321762,0.253365801062421,FALSE +"H520","Pearson.est","adrenergic receptor agonist",-0.3374,-0.815,0.703,1307,0.874,"isoetharine, buphenine, norepinephrine",0.153044674980176,0.058488567365597,FALSE +"H520","Pearson.est","adrenergic receptor antagonist",0.37425,1.12,0.288,243,0.602,"vincamine, prazosin, RS.17053, practolol, levobunolol, atenolol...., idazoxan, imiloxan, dihydroergocristine",0.540607512240769,0.220403508742175,FALSE +"H520","Pearson.est","AKT inhibitor",-0.50868,-1.24,0.196,862,0.6,"AZD5363, triciribine, GDC.0068, ONC201, uprosertib, CCT128930, A.674563",0.707743928643524,0.221848749616356,FALSE +"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.31727,-0.75,0.788,1221,0.899,"AP26113, alectinib, DMH1",0.103473782510445,0.0462403082667712,FALSE +"H520","Pearson.est","androgen receptor antagonist",-0.60977,-1.47,0.0744,1028,0.542,"nilutamide, bicalutamide, flutamide",1.12842706445412,0.266000713461613,FALSE +"H520","Pearson.est","antioxidant",-0.47738,-1.16,0.282,1283,0.719,"benfotiamine, trolox",0.549750891680639,0.143271109617117,FALSE +"H520","Pearson.est","AP inhibitor",0.55104,1.56,0.0864,33,0.455,"GDC.0152, birinapant",1.06348625752111,0.341988603342888,FALSE +"H520","Pearson.est","ATPase inhibitor",0.28511,0.797,0.683,185,0.928,"k.strophanthidin, digitoxin, ouabain, blebbistatin....",0.165579296318467,0.0324520237811379,FALSE +"H520","Pearson.est","Aurora kinase inhibitor",-0.60073,-1.42,0.077,1026,0.477,"ZM.447439, GSK1070916, CCT137690, KW.2449, CCT129202, aurora.a.inhibitor.i, ENMD.2076, AMG900, PF.03814735, barasertib.HQPA, barasertib, MK.8745, SNS.314, AT.9283, hesperadin, tozasertib",1.11350927482752,0.321481620959886,FALSE +"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.51359,-1.26,0.19,1089,0.608,"tilmicosin, josamycin, dirithromycin, radezolid",0.721246399047171,0.216096420727265,FALSE +"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.47609,1.42,0.109,191,0.45,"novobiocin, finafloxacin, sarafloxacin, sparfloxacin",0.962573502059376,0.346787486224656,FALSE +"H520","Pearson.est","BCL inhibitor",-0.46744,-1.13,0.314,1076,0.71,"gossypol, ABT.737",0.503070351926785,0.148741651280925,FALSE +"H520","Pearson.est","Bcr.Abl kinase inhibitor",-0.42933,-1.02,0.457,1098,0.823,"ponatinib, flumatinib, nilotinib, imatinib, tozasertib",0.34008379993015,0.0846001647877302,FALSE +"H520","Pearson.est","benzodiazepine receptor agonist",0.229,0.677,0.818,114,0.855,"ZK.93423, gamma.aminobutyric.acid, eprinomectin",0.087246696328677,0.0680338852718274,FALSE +"H520","Pearson.est","bromodomain inhibitor",-0.79604,-1.94,0,1175,0.0795,"OTX015, PFI.1, JQ1...., bromosporine, I.BET151",Inf,1.09963287134353,TRUE +"H520","Pearson.est","calcium channel blocker",-0.6769,-1.63,0.0281,1281,0.518,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.55129368009492,0.285670240254767,FALSE +"H520","Pearson.est","CC chemokine receptor antagonist",-0.58639,-1.43,0.0886,1109,0.543,"PF.04136309, SB.225002, navarixin",1.05256627811295,0.265200170411153,FALSE +"H520","Pearson.est","CDK inhibitor",-0.45316,-1.07,0.37,1120,0.801,"abemaciclib, NU6027, indisulam, kenpaullone, JNJ.7706621, ribociclib, indirubin, R547, arcyriaflavin.a",0.431798275933005,0.0963674839157623,FALSE +"H520","Pearson.est","CHK inhibitor",0.62225,1.78,0.0268,101,0.271,"SCH.900776, CHIR.124, LY2603618, LY2606368",1.57186520597121,0.567030709125594,FALSE +"H520","Pearson.est","cyclooxygenase inhibitor",-0.32319,-0.783,0.741,995,0.887,"curcumin, metoxibutropate, FK.3311, tepoxalin, piroxicam, aspirin, pterostilbene, naproxen, FR.122047, tryptanthrin",0.130181792020672,0.0520763801682736,FALSE +"H520","Pearson.est","cytochrome P450 inhibitor",0.40357,1.17,0.245,263,0.574,"PF.4981517, morin, eplerenone, metyrapone, itraconazole",0.610833915635468,0.241088107602027,FALSE +"H520","Pearson.est","DNA alkylating agent",-0.29826,-0.732,0.816,851,0.905,"ifosfamide, carmustine, temozolomide, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.0883098412461389,0.0433514207947967,FALSE +"H520","Pearson.est","DNA inhibitor",-0.38714,-0.909,0.585,870,0.971,"carmustine, oxaliplatin, carboplatin, valrubicin, metronidazole, pibenzimol, tirapazamine, melphalan, primaquine, mechlorethamine",0.23284413391782,0.0127807700919951,FALSE +"H520","Pearson.est","DNA methyltransferase inhibitor",-0.34487,-0.831,0.686,1055,0.901,"fdcyd, RG108, disulfiram",0.163675884293248,0.045275209020937,FALSE +"H520","Pearson.est","DNA polymerase inhibitor",0.27778,0.769,0.732,1048,0.869,"cephalomannine, menadione, famciclovir, adefovir.dipivoxil, idoxuridine, foscarnet, trifluridine, cidofovir",0.135488918941608,0.0609802235513335,FALSE +"H520","Pearson.est","DNA synthesis inhibitor",-0.29778,-0.719,0.808,623,0.889,"cisplatin, cyclocytidine, nelarabine, artemisinin, floxuridine, artesunate, anisomycin, azodicarbonamide, estramustine.phosphate, altretamine, CB.10.277, enocitabine, mitomycin.c",0.0925886392254138,0.0510982390297863,FALSE +"H520","Pearson.est","dopamine receptor antagonist",-0.40314,-0.969,0.518,835,0.867,"oxiperomide, clebopride, domperidone, amisulpride, paliperidone, nemonapride, UH.232...., lurasidone, mesoridazine",0.285670240254767,0.0619809025237897,FALSE +"H520","Pearson.est","estrogen receptor agonist",0.43776,1.24,0.207,56,0.678,"PPT, levonorgestrel",0.684029654543082,0.168770306132937,FALSE +"H520","Pearson.est","estrogen receptor antagonist",-0.66321,-1.58,0.0457,1250,0.55,"toremifene, fulvestrant, danazol",1.34008379993015,0.259637310505756,FALSE +"H520","Pearson.est","FGFR inhibitor",-0.63791,-1.53,0.057,1025,0.434,"orantinib, PD.173074, erdafitinib, MK.2461, lenvatinib, lucitanib",1.24412514432751,0.362510270487489,FALSE +"H520","Pearson.est","FLT3 inhibitor",-0.59095,-1.42,0.0862,954,0.477,"pacritinib, lestaurtinib, sunitinib, midostaurin, ponatinib, KW.2449, tandutinib, sorafenib, ENMD.2076, TG.101348, GTP.14564, quizartinib, tozasertib",1.06449273417529,0.321481620959886,FALSE +"H520","Pearson.est","glucocorticoid receptor agonist",0.26934,0.78,0.73,115,0.902,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone",0.136677139879544,0.0447934624580583,FALSE +"H520","Pearson.est","glutamate receptor antagonist",0.25807,0.746,0.742,139,0.81,"SIB.1757, latrepirdine, kynurenic.acid",0.129596094720973,0.0915149811213502,FALSE +"H520","Pearson.est","glycogen synthase kinase inhibitor",-0.5495,-1.33,0.151,1179,0.558,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, CHIR.98014, indirubin",0.821023052706831,0.253365801062421,FALSE +"H520","Pearson.est","growth factor receptor inhibitor",-0.52103,-1.26,0.188,819,0.608,"AZD3463, danusertib, GSK1904529A, lestaurtinib, GSK1838705A, GW.441756",0.72584215073632,0.216096420727265,FALSE +"H520","Pearson.est","HCV inhibitor",0.27385,0.768,0.719,44,0.822,"daclatasvir",0.143271109617117,0.0851281824599496,FALSE +"H520","Pearson.est","HDAC inhibitor",-0.54114,-1.29,0.163,996,0.627,"dacinostat, ACY.1215, PCI.24781, entinostat, panobinostat, scriptaid, AR.42, trichostatin.a, givinostat, vorinostat, RG2833, resminostat, M.344, R306465, RGFP966",0.787812395596042,0.202732459169284,FALSE +"H520","Pearson.est","histamine receptor antagonist",-0.25236,-0.612,0.918,1445,0.947,"epinastine",0.0371573187987575,0.0236500209967266,FALSE +"H520","Pearson.est","HMGCR inhibitor",-0.3457,-0.83,0.692,759,0.884,"atorvastatin, mevastatin, lovastatin, fluvastatin",0.159893905543242,0.0535477349869269,FALSE +"H520","Pearson.est","HSP inhibitor",0.5048,1.42,0.124,198,0.45,"BIIB021, KW.2478, NVP.AUY922, SNX.5422, SNX.2112, ganetespib, alvespimycin",0.906578314837765,0.346787486224656,FALSE +"H520","Pearson.est","JAK inhibitor",-0.37616,-0.905,0.594,753,0.954,"AZ960, WHI.P154, atiprimod, TG.02, pacritinib, CEP.33779, lestaurtinib, LY2784544, AZD1480, TG.101348, AT.9283, TG.101209, tozasertib",0.226213555018806,0.0204516252959049,FALSE +"H520","Pearson.est","KIT inhibitor",-0.44326,-1.06,0.405,1203,0.8,"tandutinib, imatinib, sorafenib, lenvatinib, KI.8751, masitinib",0.392544976785331,0.0969100130080564,FALSE +"H520","Pearson.est","MDM inhibitor",-0.59462,-1.43,0.0744,1158,0.543,"serdemetan, RITA",1.12842706445412,0.265200170411153,FALSE +"H520","Pearson.est","MEK inhibitor",0.63993,1.83,0.0179,91,0.428,"trametinib, selumetinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, cobimetinib, AZD8330, TAK.733",1.74714696902011,0.368556230986828,FALSE +"H520","Pearson.est","MET inhibitor",-0.53035,-1.27,0.182,1385,0.647,"NVP.BVU972, AMG458",0.739928612014925,0.1890957193313,FALSE +"H520","Pearson.est","microtubule inhibitor",-0.32868,-0.777,0.737,900,0.879,"cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.132532512140949,0.0560111249262281,FALSE +"H520","Pearson.est","mTOR inhibitor",-0.43418,-1.05,0.399,813,0.799,"deforolimus, WYE.125132, AZD8055, voxtalisib, torin.2, PF.05212384, PKI.179, sirolimus, LY3023414, XL388, LY303511, torin.1, PF.04691502, GSK2126458, ku.0063794, WYE.354, AZD2014, SB.2343",0.399027104313252,0.0974532206860086,FALSE +"H520","Pearson.est","NFkB pathway inhibitor",-0.3597,-0.874,0.605,1351,0.906,"betulinic.acid, EVP4593",0.218244625347531,0.0428718023231869,FALSE +"H520","Pearson.est","opioid receptor agonist",-0.36211,-0.862,0.626,733,0.906,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.20342566678957,0.0428718023231869,FALSE +"H520","Pearson.est","p38 MAPK inhibitor",-0.52127,-1.25,0.201,1366,0.602,"SB.239063, skepinone.l",0.696803942579511,0.220403508742175,FALSE +"H520","Pearson.est","PARP inhibitor",-0.71313,-1.68,0.0144,1261,0.537,"AG.14361, E7449, PJ.34, niraparib",1.84163750790475,0.270025714300444,FALSE +"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49223,-1.18,0.261,1023,0.696,"crenolanib, orantinib, sunitinib, ponatinib, linifanib, axitinib, tandutinib, imatinib, sorafenib, lenvatinib, KI.8751, masitinib",0.583359492661719,0.157390760389438,FALSE +"H520","Pearson.est","phosphatase inhibitor",-0.40914,-0.991,0.469,685,0.866,"bis.maltolato.oxovanadium.IV., AS.1949490, BVT.948, sodium.stibogluconate, CID.5458317, alexidine, GSK2830371",0.328827157284917,0.0624821079826534,FALSE +"H520","Pearson.est","phosphodiesterase inhibitor",0.43602,1.23,0.221,821,0.601,"cilostamide, EMD.53998, enoximone, anagrelide, avanafil, papaverine, zardaverine, YM.976, GSK256066, trequinsin",0.655607726314889,0.22112552799726,FALSE +"H520","Pearson.est","PI3K inhibitor",-0.41601,-0.99,0.485,781,0.844,"pilaralisib, PI.828, voxtalisib, TG.100713, BGT226, PF.05212384, PKI.179, YM.201636, LY3023414, AZD6482, LY303511, GDC.0941, PF.04691502, GSK2126458, CH5132799, CUDC.907, SB.2343",0.314258261397736,0.073657553374345,FALSE +"H520","Pearson.est","PLK inhibitor",-0.3747,-0.9,0.607,704,0.941,"BI.2536, volasertib, NMS.1286937, rigosertib, GW.843682X",0.216811308924742,0.0264103765727431,FALSE +"H520","Pearson.est","potassium channel blocker",0.33742,0.986,0.438,138,0.683,"dofetilide, mepivacaine",0.3585258894959,0.165579296318467,FALSE +"H520","Pearson.est","PPAR receptor agonist",-0.33752,-0.808,0.719,1255,0.867,"pterostilbene",0.143271109617117,0.0619809025237897,FALSE +"H520","Pearson.est","progesterone receptor agonist",-0.33263,-0.816,0.709,1308,0.889,"melengestrol.acetate, danazol",0.149353764816933,0.0510982390297863,FALSE +"H520","Pearson.est","proteasome inhibitor",0.3242,0.949,0.48,129,0.703,"carfilzomib, MG.132",0.318758762624413,0.153044674980176,FALSE +"H520","Pearson.est","protein synthesis inhibitor",-0.29759,-0.727,0.79,1205,0.896,"thiostrepton, florfenicol, azomycin..2.nitroimidazole.",0.102372908709559,0.0476919903378748,FALSE +"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.36831,-0.887,0.591,910,0.945,"CP.724714, NVP.TAE226, BMS.599626, mubritinib",0.228412519118745,0.0245681914907371,FALSE +"H520","Pearson.est","RAF inhibitor",-0.25985,-0.619,0.902,1027,0.958,"RAF265, CEP.32496, sorafenib, TAK.632",0.0447934624580583,0.0186344909214556,FALSE +"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.34244,-0.834,0.675,989,0.915,"apatinib, sunitinib, cabozantinib, sorafenib",0.170696227168975,0.0385789059335517,FALSE +"H520","Pearson.est","retinoid receptor agonist",-0.61623,-1.53,0.0465,1258,0.434,"adapalene, fenretinide, bexarotene",1.33254704711005,0.362510270487489,FALSE +"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.2577,-0.624,0.914,746,0.97,"fludarabine, clofarabine, cytarabine, cladribine, pentostatin",0.0390538042661686,0.0132282657337552,FALSE +"H520","Pearson.est","serotonin receptor agonist",-0.65109,-1.54,0.0442,1320,0.57,"ipsapirone, aripiprazole",1.35457773065091,0.244125144327509,FALSE +"H520","Pearson.est","serotonin receptor antagonist",-0.58782,-1.4,0.0976,1389,0.489,"lurasidone, aripiprazole",1.01055018233331,0.31069114087638,FALSE +"H520","Pearson.est","sodium channel blocker",-0.46987,-1.13,0.312,968,0.71,"cibenzoline, oxcarbazepine, A.803467, ajmaline, triamterene, quinidine, lappaconite",0.505845405981557,0.148741651280925,FALSE +"H520","Pearson.est","src inhibitor",0.38442,1.09,0.303,18,0.601,"dasatinib, saracatinib",0.518557371497695,0.22112552799726,FALSE +"H520","Pearson.est","sterol demethylase inhibitor",-0.57116,-1.35,0.123,1004,0.581,"terconazole, ketoconazole",0.910094888560602,0.235823867609669,FALSE +"H520","Pearson.est","TGF beta receptor inhibitor",-0.36183,-0.875,0.629,1381,0.925,"adaprev",0.201349354554731,0.0338582672609674,FALSE +"H520","Pearson.est","thymidylate synthase inhibitor",0.42381,1.19,0.209,207,0.6,"capecitabine, doxifluridine, ftorafur",0.679853713888946,0.221848749616356,FALSE +"H520","Pearson.est","topoisomerase inhibitor",-0.36852,-0.883,0.612,892,0.931,"fleroxacin, camptothecin, nemorubicin, rubitecan, valrubicin, etoposide.phosphate, voreloxin, SN.38, genz.644282, TAS.103, dexrazoxane, irinotecan",0.213248577854439,0.0310503190186574,FALSE +"H520","Pearson.est","tubulin polymerization inhibitor",-0.19093,-0.463,0.99,800,0.988,"parbendazole, albendazole, flubendazole, indibulin, nocodazole, plinabulin, docetaxel, ABT.751, KX2.391, epothilone.d",0.00436480540245009,0.00524305541237188,FALSE +"H520","Pearson.est","tyrosine kinase inhibitor",-0.25436,-0.609,0.925,962,0.934,"tyrphostin.AG.99, apatinib, NVP.TAE226, sunitinib, cabozantinib, BMS.599626, sorafenib, mubritinib, GTP.14564, UNC2250",0.0338582672609674,0.0296531237699066,FALSE +"H520","Pearson.est","VEGFR inhibitor",-0.34613,-0.838,0.671,1025,0.928,"orantinib, RAF265, sunitinib, PD.173074, cabozantinib, linifanib, axitinib, MK.2461, sorafenib, lenvatinib, ENMD.2076, tivozanib, MGCD.265, lucitanib, KI.8751",0.173277479831008,0.0324520237811379,FALSE +"H520","Pearson.est","vitamin D receptor agonist",-0.4907,-1.19,0.253,979,0.699,"ercalcitriol, maxacalcitol, paricalcitol, tacalcitol",0.596879478824182,0.155522824254319,FALSE +"HCC15","Pearson.est","EGFR inhibitor",0.47478,1.32,0.182,249,0.451,"pelitinib, canertinib, vandetanib, XL.647, rociletinib, afatinib, erlotinib, BMS.690514, brigatinib, CUDC.101, dacomitinib, AZD8931, neratinib, lapatinib, PD.168393, poziotinib, AEE788, gefitinib, osimertinib",0.739928612014925,0.345823458122039,FALSE +"HCC15","Pearson.est","Abl kinase inhibitor",-0.47548,-1.18,0.271,1010,0.743,"metatinib, KW.2449, flumatinib, imatinib, nilotinib, ponatinib, tozasertib",0.567030709125594,0.129011186239425,FALSE +"HCC15","Pearson.est","acetylcholine receptor agonist",-0.43946,-1.07,0.377,1160,0.688,"nicotine, nefiracetam, pilocarpine",0.423658649794207,0.162411561764489,FALSE +"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.5104,-1.24,0.218,736,0.738,"hyoscyamine, darifenacin, diphemanil, dicycloverine, iododexetimide, methscopolamine",0.661543506395395,0.131943638176958,FALSE +"HCC15","Pearson.est","adenosine receptor antagonist",-0.47068,-1.15,0.313,859,0.691,"sulmazole, CGS.15943, istradefylline, MRS.1220, SCH.58261",0.504455662453552,0.160521952625802,FALSE +"HCC15","Pearson.est","adrenergic receptor agonist",-0.46174,-1.12,0.351,1106,0.654,"A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.454692883534176,0.184422251675733,FALSE +"HCC15","Pearson.est","adrenergic receptor antagonist",0.408,1.12,0.314,224,0.627,"prazosin, vincamine, RS.17053, practolol, dihydroergocristine, levobunolol, idazoxan",0.503070351926785,0.202732459169284,FALSE +"HCC15","Pearson.est","AKT inhibitor",-0.38643,-0.924,0.54,923,0.848,"triciribine, uprosertib, ONC201, A.674563, CCT128930",0.267606240177031,0.0716041477432862,FALSE +"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.31408,-0.765,0.745,1222,0.896,"alectinib, AP26113, DMH1",0.127843727251707,0.0476919903378748,FALSE +"HCC15","Pearson.est","androgen receptor antagonist",-0.67075,-1.69,0.0179,1125,0.562,"nilutamide, flutamide, bicalutamide",1.74714696902011,0.250263684430939,FALSE +"HCC15","Pearson.est","antioxidant",-0.51722,-1.25,0.222,1343,0.753,"benfotiamine, trolox",0.653647025549361,0.123205023799299,FALSE +"HCC15","Pearson.est","AP inhibitor",0.5202,1.45,0.103,62,0.529,"birinapant, GDC.0152",0.987162775294828,0.276544327964814,FALSE +"HCC15","Pearson.est","ATPase inhibitor",0.26415,0.732,0.787,214,0.979,"k.strophanthidin, blebbistatin...., digitoxin",0.104025267640935,0.00921730819686218,FALSE +"HCC15","Pearson.est","Aurora kinase inhibitor",-0.54382,-1.34,0.15,1025,0.833,"barasertib.HQPA, KW.2449, AMG900, aurora.a.inhibitor.i, CCT129202, SNS.314, ENMD.2076, MK.8745, barasertib, AT.9283, PF.03814735, hesperadin, tozasertib",0.823908740944319,0.0793549985932124,FALSE +"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.53761,-1.3,0.159,1108,0.895,"josamycin, tilmicosin, radezolid, dirithromycin",0.798602875679548,0.048176964684088,FALSE +"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.49343,1.4,0.126,194,0.523,"novobiocin, finafloxacin, sarafloxacin",0.899629454882437,0.281498311132726,FALSE +"HCC15","Pearson.est","BCL inhibitor",-0.38774,-0.943,0.519,1362,0.831,"ABT.737",0.284832642151542,0.080398976215889,FALSE +"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",-0.51875,-1.27,0.203,1188,0.861,"flumatinib, imatinib, nilotinib, ponatinib, tozasertib",0.692503962086787,0.0649968485463452,FALSE +"HCC15","Pearson.est","benzodiazepine receptor agonist",0.21446,0.576,0.936,91,0.987,"ZK.93423, gamma.aminobutyric.acid",0.0287241512618947,0.00568284733036327,FALSE +"HCC15","Pearson.est","bromodomain inhibitor",-0.44616,-1.11,0.354,910,0.653,"JQ1...., PFI.1, I.BET151, bromosporine",0.450996737974212,0.185086818724926,FALSE +"HCC15","Pearson.est","calcium channel blocker",-0.48091,-1.17,0.285,1302,0.733,"cinnarazine, carboxyamidotriazole, SR.33805",0.54515513999149,0.134896025358872,FALSE +"HCC15","Pearson.est","CC chemokine receptor antagonist",-0.32237,-0.785,0.747,703,0.886,"MK.0812, UNBS.5162, SB.225002, PF.04136309, navarixin",0.126679398184601,0.0525662781129492,FALSE +"HCC15","Pearson.est","CDK inhibitor",-0.28626,-0.711,0.836,921,0.914,"AZD5438, BMS.265246, abemaciclib, JNJ.7706621, ribociclib, kenpaullone, NU6027, R547, indirubin, arcyriaflavin.a",0.0777937225609836,0.0390538042661686,FALSE +"HCC15","Pearson.est","CHK inhibitor",0.54305,1.47,0.0874,92,0.617,"SCH.900776, LY2603618, CHIR.124",1.0584885673656,0.209714835966758,FALSE +"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.32676,-0.819,0.679,1053,0.888,"tepoxalin, FK.3311, indoprofen, aspirin, piroxicam, metoxibutropate, pterostilbene, naproxen, FR.122047, tryptanthrin",0.168130225719498,0.051587034221399,FALSE +"HCC15","Pearson.est","cytochrome P450 inhibitor",-0.23832,-0.571,0.94,1330,0.978,"clotrimazole",0.0268721464003014,0.00966114521239857,FALSE +"HCC15","Pearson.est","DNA alkylating agent",-0.35014,-0.841,0.657,1026,0.893,"carmustine, temozolomide, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.182434630440219,0.0491485411114536,FALSE +"HCC15","Pearson.est","DNA inhibitor",-0.39646,-0.972,0.499,1026,0.819,"carmustine, pibenzimol, primaquine, carboplatin, melphalan, metronidazole, tirapazamine, mechlorethamine",0.30189945437661,0.0867160982395816,FALSE +"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.44184,1.24,0.213,177,0.521,"decitabine, SGI.1027, azacitidine",0.671620396561262,0.283162276700476,FALSE +"HCC15","Pearson.est","DNA polymerase inhibitor",0.33542,0.893,0.569,965,0.774,"cephalomannine, menadione, idoxuridine, adefovir.dipivoxil, famciclovir, trifluridine, foscarnet, cidofovir",0.244887733604929,0.111259039317107,FALSE +"HCC15","Pearson.est","DNA synthesis inhibitor",-0.34133,-0.818,0.709,1070,0.871,"estramustine.phosphate, enocitabine, CB.10.277, altretamine, mitomycin.c",0.149353764816933,0.0599818449923368,FALSE +"HCC15","Pearson.est","dopamine receptor antagonist",-0.44915,-1.09,0.378,811,0.671,"ziprasidone, domperidone, clebopride, oxiperomide, raclopride, amisulpride, paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.422508200162775,0.173277479831008,FALSE +"HCC15","Pearson.est","estrogen receptor agonist",0.46611,1.32,0.178,43,0.451,"PPT, levonorgestrel",0.749579997691106,0.345823458122039,FALSE +"HCC15","Pearson.est","estrogen receptor antagonist",-0.78428,-1.92,0.00425,1314,0.138,"toremifene, fulvestrant, danazol",2.37161106994969,0.860120913598763,TRUE +"HCC15","Pearson.est","FGFR inhibitor",-0.68967,-1.68,0.025,1112,0.403,"PD.173074, orantinib, MK.2461, lucitanib, lenvatinib, erdafitinib",1.60205999132796,0.39469495385889,FALSE +"HCC15","Pearson.est","FLT3 inhibitor",-0.62344,-1.48,0.0751,1048,0.599,"sorafenib, KW.2449, sunitinib, ENMD.2076, midostaurin, TG.101348, tandutinib, GTP.14564, ponatinib, quizartinib, tozasertib",1.12436006299583,0.222573177610689,FALSE +"HCC15","Pearson.est","glucocorticoid receptor agonist",0.41327,1.14,0.292,297,0.643,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, fluocinolone.acetonide, prednisolone, fludroxycortide, triamcinolone.acetonide, desonide, halcinonide",0.534617148551582,0.191789027075778,FALSE +"HCC15","Pearson.est","glutamate receptor antagonist",-0.26697,-0.646,0.884,1307,0.952,"MTPG, IEM1754",0.0535477349869269,0.0213630516155257,FALSE +"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.50164,-1.23,0.199,1259,0.725,"GSK.3.inhibitor.IX, LY2090314, indirubin, CHIR.98014",0.701146923590293,0.139661993429006,FALSE +"HCC15","Pearson.est","growth factor receptor inhibitor",-0.48406,-1.16,0.311,889,0.696,"GSK1904529A, lestaurtinib, GSK1838705A, GW.441756",0.507239610973163,0.157390760389438,FALSE +"HCC15","Pearson.est","HCV inhibitor",0.31572,0.885,0.591,73,0.748,"daclatasvir",0.228412519118745,0.126098402135539,FALSE +"HCC15","Pearson.est","HDAC inhibitor",-0.42309,-1.01,0.447,1147,0.764,"givinostat, trichostatin.a, vorinostat, M.344, RG2833, resminostat, R306465, RGFP966",0.349692476868064,0.11690664142431,FALSE +"HCC15","Pearson.est","histamine receptor antagonist",-0.34289,-0.833,0.684,1175,0.886,"BF2.649, lafutidine, tecastemizole, epinastine",0.164943898279884,0.0525662781129492,FALSE +"HCC15","Pearson.est","HMGCR inhibitor",-0.59352,-1.46,0.0816,929,0.515,"mevastatin, atorvastatin, lovastatin, fluvastatin",1.08830984124614,0.288192770958809,FALSE +"HCC15","Pearson.est","HSP inhibitor",0.61353,1.71,0.028,204,0.478,"BIIB021, KW.2478, SNX.5422, NVP.AUY922, SNX.2112, alvespimycin, ganetespib",1.55284196865778,0.320572103387881,FALSE +"HCC15","Pearson.est","JAK inhibitor",-0.32444,-0.791,0.726,904,0.895,"lestaurtinib, LY2784544, CEP.33779, AZD1480, AT.9283, TG.101348, TG.101209, tozasertib",0.139063379299906,0.048176964684088,FALSE +"HCC15","Pearson.est","KIT inhibitor",-0.46522,-1.13,0.32,1048,0.68,"sorafenib, sunitinib, midostaurin, imatinib, tandutinib, lenvatinib, KI.8751, masitinib",0.494850021680094,0.167491087293764,FALSE +"HCC15","Pearson.est","MDM inhibitor",-0.51524,-1.26,0.205,1063,0.777,"serdemetan, RITA",0.688246138944246,0.109578981199086,FALSE +"HCC15","Pearson.est","MEK inhibitor",0.65741,1.83,0.0276,188,0.562,"trametinib, AS.703026, selumetinib, Ro.4987655, cobimetinib, AZD8330, MEK1.2.inhibitor, TAK.733, PD.0325901, PD.198306",1.55909091793478,0.250263684430939,FALSE +"HCC15","Pearson.est","MET inhibitor",-0.64383,-1.58,0.0435,1418,0.595,"NVP.BVU972, AMG458",1.36151074304536,0.22548303427145,FALSE +"HCC15","Pearson.est","microtubule inhibitor",0.2114,0.599,0.952,1144,1,"secnidazole, vinflunine, triclabendazole, podophyllotoxin, vinblastine, cytochalasin.b, cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.0213630516155257,0,FALSE +"HCC15","Pearson.est","mTOR inhibitor",-0.40126,-0.969,0.48,1013,0.802,"XL388, LY303511, GSK2126458, sirolimus, LY3023414, PF.04691502, torin.1, AZD2014, ku.0063794, WYE.354, SB.2343",0.318758762624413,0.0958256317158365,FALSE +"HCC15","Pearson.est","NFkB pathway inhibitor",-0.22146,-0.531,0.96,1212,0.984,"EVP4593, betulinic.acid",0.0177287669604316,0.00700490156865849,FALSE +"HCC15","Pearson.est","opioid receptor agonist",-0.48178,-1.16,0.284,873,0.696,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.546681659952962,0.157390760389438,FALSE +"HCC15","Pearson.est","p38 MAPK inhibitor",-0.49778,-1.2,0.248,1140,0.729,"TAK.715, SB.239063, skepinone.l",0.605548319173784,0.137272471682025,FALSE +"HCC15","Pearson.est","PARP inhibitor",-0.63255,-1.52,0.0559,1210,0.568,"niraparib, AG.14361, PJ.34, E7449",1.25258819211358,0.245651664288981,FALSE +"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.50328,-1.22,0.219,1048,0.714,"sorafenib, crenolanib, axitinib, sunitinib, orantinib, linifanib, imatinib, tandutinib, ponatinib, lenvatinib, KI.8751, masitinib",0.659555885159882,0.146301788223826,FALSE +"HCC15","Pearson.est","phosphatase inhibitor",-0.46787,-1.13,0.317,869,0.68,"AS.1949490, sodium.stibogluconate, bis.maltolato.oxovanadium.IV., CID.5458317, alexidine, GSK2830371, BVT.948",0.498940737782249,0.167491087293764,FALSE +"HCC15","Pearson.est","phosphodiesterase inhibitor",0.23922,0.654,0.878,1104,1,"cilostamide, EMD.53998, enoximone, avanafil, anagrelide, papaverine, trequinsin, zardaverine, YM.976, GSK256066",0.0565054840938974,0,FALSE +"HCC15","Pearson.est","PI3K inhibitor",-0.37127,-0.917,0.571,781,0.839,"PI3K.IN.2, pilaralisib, PKI.179, BGT226, voxtalisib, PI.828, TG.100713, TG100.115, LY303511, GSK2126458, CUDC.907, LY3023414, PF.04691502, AZD6482, GDC.0941, CH5132799, SB.2343",0.243363891754152,0.0762380391712997,FALSE +"HCC15","Pearson.est","PLK inhibitor",0.32894,0.906,0.53,974,0.792,"HMN.214, GSK461364, BI.2536, NMS.1286937, volasertib, rigosertib, GW.843682X",0.275724130399211,0.101274818410506,FALSE +"HCC15","Pearson.est","potassium channel blocker",0.23739,0.657,0.884,280,1,"dofetilide, mepivacaine, oleoylethanolamide",0.0535477349869269,0,FALSE +"HCC15","Pearson.est","PPAR receptor agonist",-0.3589,-0.875,0.632,1298,0.855,"pterostilbene",0.199282921717615,0.0680338852718274,FALSE +"HCC15","Pearson.est","progesterone receptor agonist",-0.29644,-0.727,0.816,978,0.912,"norethindrone, dienogest, melengestrol.acetate, danazol",0.0883098412461389,0.0400051616715838,FALSE +"HCC15","Pearson.est","proteasome inhibitor",0.47929,1.35,0.116,102,0.524,"carfilzomib, MG.132",0.935542010773082,0.280668713016273,FALSE +"HCC15","Pearson.est","protein synthesis inhibitor",0.37253,1.02,0.4,151,0.77,"homoharringtonine, anguidine, bruceantin, cycloheximide, chloramphenicol.palmitate, clofoctol",0.397940008672038,0.113509274827518,FALSE +"HCC15","Pearson.est","protein tyrosine kinase inhibitor",-0.2349,-0.571,0.943,674,0.978,"NVP.TAE226, PP.121, rheochrysidin, mubritinib, BMS.599626",0.0254883072626717,0.00966114521239857,FALSE +"HCC15","Pearson.est","RAF inhibitor",0.33598,0.944,0.5,103,0.817,"AZ.628, LGX818, vemurafenib",0.301029995663981,0.0877779434675845,FALSE +"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.33888,0.928,0.516,20,0.797,"vandetanib",0.287350298372789,0.0985416786038876,FALSE +"HCC15","Pearson.est","retinoid receptor agonist",-0.43174,-1.05,0.403,1150,0.708,"fenretinide, adapalene, bexarotene",0.39469495385889,0.149966742310231,FALSE +"HCC15","Pearson.est","ribonucleotide reductase inhibitor",-0.30566,-0.742,0.777,812,0.909,"hydroxyurea, clofarabine, fludarabine, cytarabine, cladribine, pentostatin",0.109578981199086,0.0414361167780325,FALSE +"HCC15","Pearson.est","serotonin receptor agonist",-0.62101,-1.52,0.0516,1326,0.568,"ipsapirone, aripiprazole",1.28735029837279,0.245651664288981,FALSE +"HCC15","Pearson.est","serotonin receptor antagonist",-0.52143,-1.29,0.185,1351,0.857,"lurasidone, aripiprazole",0.732828271596986,0.0670191780768018,FALSE +"HCC15","Pearson.est","sodium channel blocker",-0.46388,-1.12,0.343,1030,0.654,"cibenzoline, A.803467, ajmaline, oxcarbazepine, triamterene, quinidine, lappaconite",0.464705879957229,0.184422251675733,FALSE +"HCC15","Pearson.est","src inhibitor",-0.35807,-0.885,0.62,1172,0.858,"PP.1, KX2.391, masitinib",0.207608310501746,0.0665127121512946,FALSE +"HCC15","Pearson.est","sterol demethylase inhibitor",-0.60277,-1.47,0.0695,1213,0.552,"terconazole, ketoconazole",1.15801519540989,0.258060922270801,FALSE +"HCC15","Pearson.est","TGF beta receptor inhibitor",-0.36973,-0.892,0.599,1389,0.866,"adaprev",0.222573177610689,0.0624821079826534,FALSE +"HCC15","Pearson.est","thymidylate synthase inhibitor",0.54786,1.52,0.0885,219,0.693,"capecitabine, doxifluridine, ftorafur",1.05305672930217,0.159266765388193,FALSE +"HCC15","Pearson.est","topoisomerase inhibitor",-0.17282,-0.415,0.997,865,0.996,"camptothecin, voreloxin, nemorubicin, rubitecan, SN.38, etoposide.phosphate, genz.644282, TAS.103, fleroxacin, dexrazoxane, irinotecan",0.00130484168834428,0.00174066157630127,FALSE +"HCC15","Pearson.est","tubulin polymerization inhibitor",0.34779,0.953,0.457,402,0.856,"mebendazole, paclitaxel, CYT.997, BNC105, vindesine, vincristine, taltobulin, fosbretabulin, vinorelbine, epothilone.b, fenbendazole, oxibendazole, verubulin, podophyllotoxin, dolastatin.10",0.34008379993015,0.0675262353228468,FALSE +"HCC15","Pearson.est","tyrosine kinase inhibitor",0.20817,0.567,0.956,196,0.953,"vandetanib, dasatinib, hypericin, AV.412, tivantinib",0.0195421077238999,0.0209070993616736,FALSE +"HCC15","Pearson.est","VEGFR inhibitor",-0.28477,-0.693,0.848,1039,0.918,"cabozantinib, sorafenib, axitinib, sunitinib, PD.173074, orantinib, ENMD.2076, linifanib, MK.2461, lucitanib, lenvatinib, tivozanib, MGCD.265, KI.8751",0.0716041477432862,0.0371573187987575,FALSE +"HCC15","Pearson.est","vitamin D receptor agonist",-0.50547,-1.26,0.211,919,0.777,"ercalcitriol, maxacalcitol, tacalcitol, paricalcitol",0.675717544702307,0.109578981199086,FALSE +"H460","Pearson.est","EGFR inhibitor",0.43205,1.29,0.153,190,0.536,"pelitinib, canertinib, vandetanib, erlotinib, BMS.690514, XL.647, rociletinib, brigatinib, afatinib, AZD8931, dacomitinib, poziotinib, PD.168393, lapatinib, neratinib, icotinib, gefitinib",0.815308569182401,0.27083521030723,FALSE +"H460","Pearson.est","Abl kinase inhibitor",-0.50146,-1.22,0.224,1030,0.634,"metatinib, flumatinib, nilotinib, imatinib, KW.2449, ponatinib, tozasertib",0.649751981665837,0.197910742118267,FALSE +"H460","Pearson.est","acetylcholine receptor agonist",-0.47795,-1.17,0.279,1004,0.605,"xanomeline, nicotine, nefiracetam, pilocarpine",0.554395796726402,0.218244625347531,FALSE +"H460","Pearson.est","acetylcholine receptor antagonist",-0.40278,-0.978,0.501,716,0.794,"diphemanil, dicycloverine, iododexetimide, methscopolamine",0.300162274132754,0.100179497572904,FALSE +"H460","Pearson.est","adenosine receptor antagonist",-0.50493,-1.22,0.209,781,0.634,"sulmazole, istradefylline, CGS.15943, MRS.1220, SCH.58261",0.679853713888946,0.197910742118267,FALSE +"H460","Pearson.est","adrenergic receptor agonist",-0.40212,-0.976,0.5,1065,0.778,"clenbuterol, A61603, isoxsuprine, isoetharine, buphenine, norepinephrine",0.301029995663981,0.109020403010311,FALSE +"H460","Pearson.est","adrenergic receptor antagonist",0.36417,1.04,0.341,150,0.65,"prazosin, vincamine, RS.17053, practolol, imiloxan, atenolol....",0.467245621007502,0.187086643357144,FALSE +"H460","Pearson.est","AKT inhibitor",-0.51338,-1.25,0.214,1119,0.645,"triciribine, ONC201, CCT128930, uprosertib, A.674563",0.669586226650809,0.190440285364732,FALSE +"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.2693,-0.663,0.874,1162,0.933,"AP26113, alectinib, DMH1",0.058488567365597,0.0301183562535,FALSE +"H460","Pearson.est","androgen receptor antagonist",-0.50086,-1.21,0.242,840,0.631,"nilutamide, flutamide, bicalutamide",0.616184634019569,0.199970640755866,FALSE +"H460","Pearson.est","antioxidant",-0.48458,-1.17,0.278,1302,0.605,"benfotiamine, trolox",0.555955204081924,0.218244625347531,FALSE +"H460","Pearson.est","AP inhibitor",0.53199,1.54,0.0667,36,0.695,"birinapant, GDC.0152",1.17587416608345,0.158015195409886,FALSE +"H460","Pearson.est","ATPase inhibitor",0.32177,0.94,0.498,101,0.639,"k.strophanthidin, ouabain, digitoxin",0.302770657240282,0.1944991418416,FALSE +"H460","Pearson.est","Aurora kinase inhibitor",-0.66418,-1.59,0.0362,1143,0.726,"ZM.447439, CCT129202, CCT137690, aurora.a.inhibitor.i, KW.2449, AMG900, ENMD.2076, barasertib.HQPA, PF.03814735, MK.8745, barasertib, SNS.314, AT.9283, hesperadin, tozasertib",1.44129142946683,0.139063379299906,FALSE +"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.59487,-1.43,0.094,978,0.507,"azalomycin.b, tilmicosin, valnemulin, josamycin, radezolid, dirithromycin",1.0268721464003,0.294992040666664,FALSE +"H460","Pearson.est","bacterial DNA gyrase inhibitor",0.47257,1.39,0.142,216,0.777,"sarafloxacin, finafloxacin, novobiocin, sparfloxacin",0.847711655616944,0.109578981199086,FALSE +"H460","Pearson.est","BCL inhibitor",-0.54623,-1.34,0.133,1221,0.581,"gossypol, ABT.737",0.876148359032914,0.235823867609669,FALSE +"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.4812,-1.17,0.277,1030,0.605,"metatinib, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.557520230935551,0.218244625347531,FALSE +"H460","Pearson.est","benzodiazepine receptor agonist",0.22779,0.666,0.858,126,0.87,"ZK.93423, gamma.aminobutyric.acid, eprinomectin",0.0665127121512946,0.0604807473813815,FALSE +"H460","Pearson.est","bromodomain inhibitor",-0.78728,-1.89,0.00254,1168,0.177,"OTX015, PFI.1, JQ1...., bromosporine, I.BET151",2.59516628338006,0.752026733638193,TRUE +"H460","Pearson.est","calcium channel blocker",-0.65167,-1.57,0.0431,1236,0.617,"cinnarazine, mibefradil, carboxyamidotriazole, SR.33805",1.36552272983927,0.209714835966758,FALSE +"H460","Pearson.est","CC chemokine receptor antagonist",-0.57927,-1.39,0.112,1130,0.574,"SB.225002, PF.04136309, navarixin",0.950781977329818,0.241088107602027,FALSE +"H460","Pearson.est","CDK inhibitor",-0.53921,-1.3,0.166,1054,0.577,"palbociclib, NU6027, AZD5438, BMS.265246, JNJ.7706621, kenpaullone, indisulam, abemaciclib, ribociclib, indirubin, arcyriaflavin.a, R547",0.779891911959945,0.238824186844269,FALSE +"H460","Pearson.est","CHK inhibitor",0.48955,1.36,0.113,109,0.648,"SCH.900776, CHIR.124, LY2603618",0.94692155651658,0.188424994129407,FALSE +"H460","Pearson.est","cyclooxygenase inhibitor",-0.32242,-0.796,0.71,933,0.897,"curcumin, metoxibutropate, indoprofen, FK.3311, tepoxalin, piroxicam, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.148741651280925,0.0472075569559079,FALSE +"H460","Pearson.est","cytochrome P450 inhibitor",0.39152,1.11,0.307,256,0.576,"PF.4981517, morin, eplerenone, metyrapone",0.512861624522813,0.239577516576788,FALSE +"H460","Pearson.est","DNA alkylating agent",-0.35346,-0.86,0.649,776,0.884,"carmustine, temozolomide, cisplatin, carboplatin, streptozotocin, ifosfamide, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.187755303199631,0.0535477349869269,FALSE +"H460","Pearson.est","DNA inhibitor",-0.34979,-0.848,0.651,1099,0.886,"metronidazole, tirapazamine, pibenzimol, primaquine, melphalan, mechlorethamine",0.186419011431808,0.0525662781129492,FALSE +"H460","Pearson.est","DNA methyltransferase inhibitor",-0.47326,-1.16,0.28,1151,0.606,"fdcyd, RG108, disulfiram",0.552841968657781,0.217527375833714,FALSE +"H460","Pearson.est","DNA polymerase inhibitor",0.28056,0.78,0.702,1044,0.77,"cephalomannine, famciclovir, menadione, adefovir.dipivoxil, idoxuridine, cidofovir, foscarnet, trifluridine",0.153662887870195,0.113509274827518,FALSE +"H460","Pearson.est","DNA synthesis inhibitor",-0.37767,-0.929,0.575,798,0.852,"cisplatin, azodicarbonamide, artesunate, cyclocytidine, estramustine.phosphate, CB.10.277, anisomycin, altretamine, enocitabine, mitomycin.c",0.24033215531037,0.0695604052332999,FALSE +"H460","Pearson.est","dopamine receptor antagonist",-0.37798,-0.908,0.599,1110,0.873,"nemonapride, paliperidone, UH.232...., lurasidone, mesoridazine",0.222573177610689,0.0589857562944303,FALSE +"H460","Pearson.est","estrogen receptor agonist",0.44663,1.25,0.226,37,0.526,"PPT, levonorgestrel",0.645891560852599,0.279014255846261,FALSE +"H460","Pearson.est","estrogen receptor antagonist",-0.67382,-1.69,0.0218,1283,0.529,"toremifene, danazol, fulvestrant",1.6615435063954,0.276544327964814,FALSE +"H460","Pearson.est","FGFR inhibitor",-0.53145,-1.29,0.181,1092,0.571,"PD.173074, MK.2461, lenvatinib, erdafitinib, lucitanib",0.742321425130815,0.243363891754152,FALSE +"H460","Pearson.est","FLT3 inhibitor",-0.60419,-1.45,0.0875,1048,0.556,"midostaurin, pacritinib, sunitinib, tandutinib, KW.2449, ponatinib, GTP.14564, TG.101348, ENMD.2076, sorafenib, quizartinib, tozasertib",1.05799194697769,0.254925208417942,FALSE +"H460","Pearson.est","glucocorticoid receptor agonist",0.45807,1.33,0.144,206,0.569,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, fluocinolone.acetonide, triamcinolone.acetonide, ciclesonide, halcinonide, desonide",0.84163750790475,0.244887733604929,FALSE +"H460","Pearson.est","glutamate receptor antagonist",0.30342,0.887,0.594,181,0.687,"SIB.1757, latrepirdine, kynurenic.acid, CGP.37849",0.226213555018806,0.16304326294045,FALSE +"H460","Pearson.est","glycogen synthase kinase inhibitor",-0.5279,-1.3,0.185,1193,0.577,"GSK.3.inhibitor.IX, kenpaullone, LY2090314, indirubin, CHIR.98014",0.732828271596986,0.238824186844269,FALSE +"H460","Pearson.est","growth factor receptor inhibitor",-0.54454,-1.32,0.164,802,0.594,"GSK1904529A, danusertib, AZD3463, lestaurtinib, GSK1838705A, GW.441756",0.785156151952302,0.226213555018806,FALSE +"H460","Pearson.est","HCV inhibitor",-0.27137,-0.66,0.858,1304,0.906,"narlaprevir",0.0665127121512946,0.0428718023231869,FALSE +"H460","Pearson.est","HDAC inhibitor",-0.55024,-1.35,0.144,1053,0.593,"PCI.24781, panobinostat, entinostat, dacinostat, scriptaid, AR.42, givinostat, trichostatin.a, vorinostat, RG2833, resminostat, R306465, M.344, RGFP966",0.84163750790475,0.226945306635737,FALSE +"H460","Pearson.est","histamine receptor antagonist",-0.23169,-0.559,0.945,938,0.952,"chloropyramine, cyproheptadine, tecastemizole, lafutidine, BF2.649, epinastine",0.0245681914907371,0.0213630516155257,FALSE +"H460","Pearson.est","HMGCR inhibitor",-0.28774,-0.709,0.839,1077,0.914,"fluvastatin, lovastatin",0.0762380391712997,0.0390538042661686,FALSE +"H460","Pearson.est","HSP inhibitor",0.43475,1.23,0.21,278,0.493,"BIIB021, KW.2478, SNX.5422, SNX.2112, alvespimycin, NVP.AUY922, ganetespib",0.677780705266081,0.30715308072277,FALSE +"H460","Pearson.est","JAK inhibitor",-0.41197,-1.01,0.471,923,0.789,"CEP.33779, lestaurtinib, LY2784544, TG.02, AZD1480, pacritinib, TG.101348, AT.9283, TG.101209, tozasertib",0.326979092871104,0.10292299679058,FALSE +"H460","Pearson.est","KIT inhibitor",-0.41554,-1.02,0.453,1048,0.811,"midostaurin, sunitinib, tandutinib, lenvatinib, imatinib, sorafenib, KI.8751, masitinib",0.343901797987168,0.090979145788844,FALSE +"H460","Pearson.est","MDM inhibitor",-0.62445,-1.5,0.0524,1247,0.754,"serdemetan, RITA",1.28066871301627,0.122628654130226,FALSE +"H460","Pearson.est","MEK inhibitor",0.62567,1.85,0.0205,160,0.42,"selumetinib, trametinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, AZD8330, cobimetinib, TAK.733, PD.198306, PD.0325901",1.68824613894425,0.3767507096021,FALSE +"H460","Pearson.est","MET inhibitor",-0.57053,-1.37,0.109,1357,0.583,"NVP.BVU972, AMG458",0.962573502059376,0.234331445240986,FALSE +"H460","Pearson.est","microtubule inhibitor",-0.32533,-0.79,0.736,906,0.872,"estramustine.phosphate, colchicine, cabazitaxel, D.64131",0.133122185662501,0.0594835150674328,FALSE +"H460","Pearson.est","mTOR inhibitor",-0.40812,-0.99,0.476,792,0.81,"deforolimus, WYE.125132, voxtalisib, AZD8055, PKI.179, MLN0128, sirolimus, torin.2, XL388, LY303511, LY3023414, torin.1, PF.04691502, GSK2126458, ku.0063794, WYE.354, AZD2014, SB.2343",0.322393047279507,0.0915149811213502,FALSE +"H460","Pearson.est","NFkB pathway inhibitor",-0.40028,-0.982,0.492,1373,0.806,"EVP4593, betulinic.acid",0.30803489723264,0.0936649581949093,FALSE +"H460","Pearson.est","opioid receptor agonist",-0.33528,-0.811,0.704,1098,0.891,"trimebutine, cebranopadol",0.152427340857888,0.0501222959631252,FALSE +"H460","Pearson.est","p38 MAPK inhibitor",-0.49149,-1.19,0.247,915,0.627,"TAK.715, talmapimod, SB.242235, SB.239063, skepinone.l",0.607303046740334,0.202732459169284,FALSE +"H460","Pearson.est","PARP inhibitor",-0.61577,-1.49,0.048,1154,0.667,"AG.14361, PJ.34, E7449, niraparib",1.31875876262441,0.175874166083451,FALSE +"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.44807,-1.09,0.365,1066,0.718,"sunitinib, linifanib, crenolanib, tandutinib, axitinib, lenvatinib, imatinib, ponatinib, sorafenib, KI.8751, masitinib",0.437707135543525,0.1438755557577,FALSE +"H460","Pearson.est","phosphatase inhibitor",-0.43302,-1.06,0.385,745,0.765,"bis.maltolato.oxovanadium.IV., sodium.stibogluconate, AS.1949490, BVT.948, CID.5458317, alexidine, GSK2830371",0.414539270491499,0.116338564846382,FALSE +"H460","Pearson.est","phosphodiesterase inhibitor",0.33102,0.979,0.445,972,0.715,"cilostamide, EMD.53998, avanafil, enoximone, anagrelide, papaverine, zardaverine, GSK256066, trequinsin, YM.976",0.351639989019068,0.145693958198919,FALSE +"H460","Pearson.est","PI3K inhibitor",-0.37002,-0.895,0.595,899,0.879,"TG.100713, PKI.179, YM.201636, BGT226, AZD6482, GDC.0941, LY303511, LY3023414, PF.04691502, GSK2126458, CH5132799, CUDC.907, SB.2343",0.22548303427145,0.0560111249262281,FALSE +"H460","Pearson.est","PLK inhibitor",-0.46492,-1.13,0.298,902,0.653,"NMS.1286937, volasertib, BI.2536, rigosertib, GW.843682X",0.525783735923745,0.185086818724926,FALSE +"H460","Pearson.est","potassium channel blocker",0.31924,0.94,0.493,145,0.639,"dofetilide, mepivacaine",0.30715308072277,0.1944991418416,FALSE +"H460","Pearson.est","PPAR receptor agonist",-0.32679,-0.784,0.747,1216,0.864,"pterostilbene",0.126679398184601,0.0634862575211067,FALSE +"H460","Pearson.est","progesterone receptor agonist",-0.36334,-0.879,0.623,1158,0.888,"dienogest, melengestrol.acetate, danazol",0.20551195334083,0.051587034221399,FALSE +"H460","Pearson.est","proteasome inhibitor",0.29128,0.818,0.635,129,0.753,"carfilzomib, MG.132",0.197226274708024,0.123205023799299,FALSE +"H460","Pearson.est","protein synthesis inhibitor",-0.32194,-0.781,0.743,1248,0.853,"thiostrepton, florfenicol, azomycin..2.nitroimidazole.",0.129011186239425,0.069050968832477,FALSE +"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.34806,-0.841,0.694,1078,0.879,"NVP.TAE226, BMS.599626, mubritinib",0.158640529545145,0.0560111249262281,FALSE +"H460","Pearson.est","RAF inhibitor",-0.28838,-0.692,0.849,1332,0.918,"sorafenib, TAK.632",0.0710923097560473,0.0371573187987575,FALSE +"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.30763,-0.738,0.806,1066,0.895,"sunitinib, cabozantinib, sorafenib",0.0936649581949093,0.048176964684088,FALSE +"H460","Pearson.est","retinoid receptor agonist",-0.58861,-1.44,0.0834,1211,0.528,"adapalene, fenretinide, bexarotene",1.07883394936226,0.277366077466188,FALSE +"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.33067,-0.795,0.744,928,0.881,"fludarabine, clofarabine, cladribine, pentostatin",0.128427064454121,0.0550240915879521,FALSE +"H460","Pearson.est","serotonin receptor agonist",-0.59417,-1.48,0.0782,1046,0.605,"zolmitriptan, ipsapirone, aripiprazole",1.10679324694015,0.218244625347531,FALSE +"H460","Pearson.est","serotonin receptor antagonist",-0.51412,-1.24,0.21,1380,0.639,"lurasidone, aripiprazole",0.677780705266081,0.1944991418416,FALSE +"H460","Pearson.est","sodium channel blocker",-0.41969,-1.01,0.451,996,0.789,"cibenzoline, A.803467, triamterene, quinidine, ajmaline, lappaconite",0.345823458122039,0.10292299679058,FALSE +"H460","Pearson.est","src inhibitor",0.38878,1.16,0.269,11,0.553,"dasatinib, saracatinib",0.570247719997592,0.257274868695302,FALSE +"H460","Pearson.est","sterol demethylase inhibitor",-0.59928,-1.45,0.0683,1007,0.556,"terconazole, ketoconazole",1.16557929631847,0.254925208417942,FALSE +"H460","Pearson.est","TGF beta receptor inhibitor",-0.36061,-0.872,0.631,1359,0.881,"adaprev",0.199970640755866,0.0550240915879521,FALSE +"H460","Pearson.est","thymidylate synthase inhibitor",0.33524,0.966,0.495,204,0.685,"capecitabine, doxifluridine, ftorafur",0.305394801066431,0.164309428507574,FALSE +"H460","Pearson.est","topoisomerase inhibitor",-0.43336,-1.04,0.426,936,0.788,"nemorubicin, topotecan, fleroxacin, valrubicin, etoposide.phosphate, camptothecin, voreloxin, rubitecan, SN.38, dexrazoxane, genz.644282, TAS.103, irinotecan",0.370590400897281,0.103473782510445,FALSE +"H460","Pearson.est","tubulin polymerization inhibitor",-0.25649,-0.631,0.904,931,0.917,"indibulin, flubendazole, albendazole, plinabulin, nocodazole, ABT.751, docetaxel, epothilone.d, KX2.391",0.0438315695246367,0.0376306643299789,FALSE +"H460","Pearson.est","tyrosine kinase inhibitor",-0.2775,-0.661,0.879,1066,0.92,"sunitinib, NVP.TAE226, BMS.599626, cabozantinib, mubritinib, GTP.14564, sorafenib, UNC2250",0.0560111249262281,0.0362121726544447,FALSE +"H460","Pearson.est","VEGFR inhibitor",-0.34231,-0.826,0.697,1066,0.885,"sunitinib, linifanib, PD.173074, RAF265, MK.2461, cabozantinib, axitinib, lenvatinib, ENMD.2076, sorafenib, MGCD.265, tivozanib, lucitanib, KI.8751",0.156767221901991,0.0530567293021746,FALSE +"H460","Pearson.est","vitamin D receptor agonist",-0.50499,-1.2,0.247,867,0.629,"alfacalcidol, ercalcitriol, maxacalcitol, paricalcitol, tacalcitol",0.607303046740334,0.201349354554731,FALSE +"A549","Pearson.est","EGFR inhibitor",0.39186,1.09,0.32,256,0.834,"pelitinib, canertinib, vandetanib, brigatinib, erlotinib, XL.647, afatinib, rociletinib, BMS.690514, dacomitinib, neratinib, AZD8931, PD.168393, lapatinib, poziotinib, AEE788, icotinib, CUDC.101",0.494850021680094,0.0788339493622613,FALSE +"A549","Pearson.est","Abl kinase inhibitor",-0.5224,-1.27,0.18,1055,0.595,"metatinib, KW.2449, nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.744727494896694,0.22548303427145,FALSE +"A549","Pearson.est","acetylcholine receptor agonist",-0.41942,-1.03,0.432,1075,0.717,"nicotine, nefiracetam, pilocarpine",0.364516253185088,0.1444808443322,FALSE +"A549","Pearson.est","acetylcholine receptor antagonist",-0.46813,-1.12,0.339,741,0.7,"darifenacin, diphemanil, dicycloverine, iododexetimide, methscopolamine",0.469800301796918,0.154901959985743,FALSE +"A549","Pearson.est","adenosine receptor antagonist",-0.53642,-1.3,0.168,1127,0.582,"CGS.15943, MRS.1220, SCH.58261",0.774690718274137,0.235077015350112,FALSE +"A549","Pearson.est","adrenergic receptor agonist",-0.42171,-1.02,0.436,1143,0.699,"isoxsuprine, clenbuterol, isoetharine, norepinephrine, buphenine",0.360513510731414,0.155522824254319,FALSE +"A549","Pearson.est","adrenergic receptor antagonist",0.37555,1.06,0.356,272,0.681,"prazosin, vincamine, RS.17053, dihydroergocristine, levobunolol, idazoxan, imiloxan, atenolol...., practolol",0.448550002027125,0.166852888087215,FALSE +"A549","Pearson.est","AKT inhibitor",-0.48625,-1.19,0.265,991,0.644,"GDC.0068, triciribine, ONC201, uprosertib, A.674563, CCT128930",0.576754126063192,0.191114132640188,FALSE +"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.22256,0.639,0.908,64,0.894,"brigatinib, GW.788388",0.0419141514789149,0.0486624812040823,FALSE +"A549","Pearson.est","androgen receptor antagonist",-0.56106,-1.35,0.113,1004,0.715,"nilutamide, flutamide, bicalutamide",0.94692155651658,0.145693958198919,FALSE +"A549","Pearson.est","antioxidant",-0.51247,-1.23,0.231,1329,0.601,"benfotiamine, trolox",0.636388020107856,0.22112552799726,FALSE +"A549","Pearson.est","AP inhibitor",0.67189,1.98,0.0136,36,0.286,"GDC.0152, birinapant",1.86646109162978,0.543633966870957,FALSE +"A549","Pearson.est","ATPase inhibitor",0.31492,0.883,0.602,140,1,"k.strophanthidin, digitoxin, ouabain",0.220403508742175,0,FALSE +"A549","Pearson.est","Aurora kinase inhibitor",-0.61234,-1.48,0.0788,1089,0.669,"CCT137690, ENMD.2076, KW.2449, AMG900, barasertib.HQPA, SNS.314, CCT129202, aurora.a.inhibitor.i, AT.9283, PF.03814735, MK.8745, barasertib, hesperadin, tozasertib",1.10347378251044,0.174573882232177,FALSE +"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.50919,-1.24,0.189,752,0.606,"azithromycin, azalomycin.b, valnemulin, josamycin, tilmicosin, radezolid, dirithromycin",0.723538195826756,0.217527375833714,FALSE +"A549","Pearson.est","bacterial DNA gyrase inhibitor",0.48781,1.38,0.143,158,0.511,"finafloxacin, novobiocin, sarafloxacin",0.844663962534938,0.291579099865287,FALSE +"A549","Pearson.est","BCL inhibitor",-0.42032,-1.02,0.45,1203,0.699,"gossypol, ABT.737",0.346787486224656,0.155522824254319,FALSE +"A549","Pearson.est","Bcr.Abl kinase inhibitor",-0.52202,-1.26,0.217,1055,0.588,"metatinib, nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.66354026615147,0.230622673923862,FALSE +"A549","Pearson.est","benzodiazepine receptor agonist",-0.21624,-0.523,0.962,898,0.985,"ivermectin, indiplon, piperazine, temazepam, nefiracetam, lorazepam",0.0168249279621871,0.00656376950238827,FALSE +"A549","Pearson.est","bromodomain inhibitor",-0.61977,-1.49,0.0685,1095,0.761,"PFI.1, JQ1...., bromosporine, I.BET151",1.16430942850757,0.118615343229427,FALSE +"A549","Pearson.est","calcium channel blocker",-0.57959,-1.4,0.0827,1182,0.686,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.08249449044745,0.163675884293248,FALSE +"A549","Pearson.est","CC chemokine receptor antagonist",-0.42716,-1.04,0.418,1208,0.718,"PF.04136309, navarixin",0.378823718224965,0.1438755557577,FALSE +"A549","Pearson.est","CDK inhibitor",-0.45261,-1.09,0.348,1044,0.697,"AZD5438, BMS.265246, indisulam, JNJ.7706621, kenpaullone, NU6027, abemaciclib, ribociclib, indirubin, R547, arcyriaflavin.a",0.458420756053419,0.156767221901991,FALSE +"A549","Pearson.est","CHK inhibitor",0.49092,1.43,0.097,106,0.519,"SCH.900776, LY2603618, CHIR.124",1.01322826573376,0.284832642151542,FALSE +"A549","Pearson.est","cyclooxygenase inhibitor",-0.31878,-0.777,0.761,916,0.882,"metoxibutropate, curcumin, FK.3311, indoprofen, tepoxalin, piroxicam, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.118615343229427,0.0545314148681803,FALSE +"A549","Pearson.est","cytochrome P450 inhibitor",0.29378,0.847,0.612,241,0.956,"PF.4981517, eplerenone, morin",0.213248577854439,0.0195421077238999,FALSE +"A549","Pearson.est","DNA alkylating agent",-0.39862,-0.955,0.519,903,0.768,"cisplatin, ifosfamide, temozolomide, carboplatin, carmustine, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.284832642151542,0.114638779968488,FALSE +"A549","Pearson.est","DNA inhibitor",-0.38216,-0.92,0.561,1002,0.76,"carboplatin, carmustine, pibenzimol, melphalan, primaquine, metronidazole, tirapazamine, mechlorethamine",0.251037138743839,0.119186407719209,FALSE +"A549","Pearson.est","DNA methyltransferase inhibitor",0.30399,0.882,0.573,222,0.943,"decitabine, SGI.1027, azacitidine",0.24184537803261,0.0254883072626717,FALSE +"A549","Pearson.est","DNA polymerase inhibitor",0.25278,0.718,0.77,1084,0.881,"cephalomannine, menadione, famciclovir, adefovir.dipivoxil, idoxuridine, cidofovir, trifluridine, foscarnet",0.113509274827518,0.0550240915879521,FALSE +"A549","Pearson.est","DNA synthesis inhibitor",-0.31991,-0.783,0.744,698,0.909,"cyclocytidine, nelarabine, altretamine, azodicarbonamide, anisomycin, cisplatin, estramustine.phosphate, artesunate, CB.10.277, enocitabine, mitomycin.c",0.128427064454121,0.0414361167780325,FALSE +"A549","Pearson.est","dopamine receptor antagonist",-0.40492,-0.98,0.485,1120,0.739,"paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.314258261397736,0.131355561605174,FALSE +"A549","Pearson.est","estrogen receptor agonist",0.49245,1.43,0.0905,27,0.519,"PPT, levonorgestrel",1.0433514207948,0.284832642151542,FALSE +"A549","Pearson.est","estrogen receptor antagonist",-0.6821,-1.66,0.0196,1245,0.631,"toremifene, danazol, fulvestrant",1.70774392864352,0.199970640755866,FALSE +"A549","Pearson.est","FGFR inhibitor",-0.57968,-1.41,0.102,1156,0.84,"PD.173074, MK.2461, lenvatinib, lucitanib, erdafitinib",0.991399828238082,0.0757207139381184,FALSE +"A549","Pearson.est","FLT3 inhibitor",-0.57059,-1.37,0.114,1069,0.72,"sunitinib, midostaurin, ENMD.2076, KW.2449, tandutinib, GTP.14564, sorafenib, ponatinib, TG.101348, quizartinib, tozasertib",0.943095148663527,0.142667503568732,FALSE +"A549","Pearson.est","glucocorticoid receptor agonist",0.46594,1.34,0.158,286,0.495,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, fluocinolone.acetonide, ciclesonide, triamcinolone.acetonide, halcinonide, prednisolone, fludroxycortide, desonide",0.801342913045577,0.305394801066431,FALSE +"A549","Pearson.est","glutamate receptor antagonist",0.24802,0.72,0.799,171,0.922,"SIB.1757, latrepirdine, kynurenic.acid",0.0974532206860086,0.0352690789463706,FALSE +"A549","Pearson.est","glycogen synthase kinase inhibitor",-0.47883,-1.16,0.297,1016,0.686,"TWS.119, kenpaullone, LY2090314, GSK.3.inhibitor.IX, indirubin, CHIR.98014",0.527243550682788,0.163675884293248,FALSE +"A549","Pearson.est","growth factor receptor inhibitor",-0.51526,-1.27,0.224,835,0.595,"lestaurtinib, GSK1904529A, AZD3463, GSK1838705A, GW.441756",0.649751981665837,0.22548303427145,FALSE +"A549","Pearson.est","HCV inhibitor",0.26876,0.767,0.766,83,0.895,"daclatasvir",0.115771230367396,0.048176964684088,FALSE +"A549","Pearson.est","HDAC inhibitor",-0.5435,-1.3,0.172,1168,0.582,"scriptaid, panobinostat, AR.42, trichostatin.a, vorinostat, givinostat, RG2833, resminostat, M.344, R306465, RGFP966",0.764471553092451,0.235077015350112,FALSE +"A549","Pearson.est","histamine receptor antagonist",-0.31569,-0.763,0.776,1021,0.868,"cyproheptadine, nizatidine, BF2.649, tecastemizole, lafutidine, epinastine",0.110138278741812,0.0614802748235081,FALSE +"A549","Pearson.est","HMGCR inhibitor",-0.37223,-0.903,0.587,1081,0.756,"fluvastatin, lovastatin",0.231361898752386,0.121478204498793,FALSE +"A549","Pearson.est","HSP inhibitor",0.50358,1.45,0.121,248,0.802,"BIIB021, KW.2478, SNX.5422, SNX.2112, alvespimycin, ganetespib, NVP.AUY922",0.91721462968355,0.0958256317158365,FALSE +"A549","Pearson.est","JAK inhibitor",-0.37341,-0.903,0.59,1272,0.756,"AT.9283, TG.101348, TG.101209, tozasertib",0.229147988357856,0.121478204498793,FALSE +"A549","Pearson.est","KIT inhibitor",-0.4559,-1.12,0.336,1069,0.7,"sunitinib, midostaurin, imatinib, tandutinib, lenvatinib, sorafenib, KI.8751, masitinib",0.473660722610156,0.154901959985743,FALSE +"A549","Pearson.est","MDM inhibitor",-0.57102,-1.4,0.101,1138,0.686,"serdemetan, RITA",0.995678626217357,0.163675884293248,FALSE +"A549","Pearson.est","MEK inhibitor",0.64319,1.9,0.0211,164,0.207,"selumetinib, trametinib, AS.703026, Ro.4987655, cobimetinib, MEK1.2.inhibitor, TAK.733, AZD8330, PD.198306, PD.0325901",1.67571754470231,0.684029654543082,TRUE +"A549","Pearson.est","MET inhibitor",-0.66326,-1.62,0.0299,1400,0.552,"NVP.BVU972, AMG458",1.52432881167557,0.258060922270801,FALSE +"A549","Pearson.est","microtubule inhibitor",-0.16822,-0.409,0.991,1268,0.996,"D.64131",0.00392634551472468,0.00174066157630127,FALSE +"A549","Pearson.est","mTOR inhibitor",-0.4557,-1.11,0.356,725,0.701,"PF.05212384, deforolimus, AZD8055, everolimus, OSI.027, NVP.BEZ235, WYE.125132, voxtalisib, temsirolimus, torin.2, PKI.179, LY303511, MLN0128, XL388, sirolimus, PF.04691502, torin.1, GSK2126458, LY3023414, ku.0063794, AZD2014, WYE.354, SB.2343",0.448550002027125,0.154281982033341,FALSE +"A549","Pearson.est","NFkB pathway inhibitor",-0.38839,-0.929,0.567,1342,0.761,"EVP4593, betulinic.acid",0.246416941107093,0.118615343229427,FALSE +"A549","Pearson.est","opioid receptor agonist",-0.43594,-1.07,0.395,944,0.718,"salvinorin.a, trimebutine, cebranopadol",0.40340290437354,0.1438755557577,FALSE +"A549","Pearson.est","p38 MAPK inhibitor",-0.54469,-1.3,0.143,1039,0.582,"TAK.715, SB.242235, SB.239063, skepinone.l",0.844663962534938,0.235077015350112,FALSE +"A549","Pearson.est","PARP inhibitor",-0.62814,-1.51,0.055,1223,0.845,"AG.14361, E7449, PJ.34, niraparib",1.25963731050576,0.0731432910503077,FALSE +"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.46497,-1.13,0.315,1144,0.729,"crenolanib, linifanib, imatinib, tandutinib, axitinib, lenvatinib, sorafenib, ponatinib, KI.8751, masitinib",0.501689446210399,0.137272471682025,FALSE +"A549","Pearson.est","phosphatase inhibitor",-0.49594,-1.19,0.273,927,0.644,"AS.1949490, sodium.stibogluconate, CID.5458317, BVT.948, alexidine, GSK2830371",0.563837352959244,0.191114132640188,FALSE +"A549","Pearson.est","phosphodiesterase inhibitor",0.29833,0.829,0.633,1019,0.933,"cilostamide, EMD.53998, anagrelide, enoximone, avanafil, trequinsin, papaverine, zardaverine, GSK256066, YM.976",0.198596289982645,0.0301183562535,FALSE +"A549","Pearson.est","PI3K inhibitor",-0.42734,-1.04,0.414,828,0.718,"TG100.115, NVP.BEZ235, voxtalisib, YM.201636, TG.100713, PI3K.IN.2, PKI.179, BGT226, LY303511, AZD6482, PF.04691502, GSK2126458, LY3023414, GDC.0941, CUDC.907, CH5132799, SB.2343",0.382999658879101,0.1438755557577,FALSE +"A549","Pearson.est","PLK inhibitor",-0.24423,-0.586,0.933,872,0.966,"volasertib, rigosertib, GW.843682X",0.0301183562535,0.0150228735845067,FALSE +"A549","Pearson.est","potassium channel blocker",0.27369,0.791,0.733,160,0.9,"dofetilide, mepivacaine",0.134896025358872,0.0457574905606751,FALSE +"A549","Pearson.est","PPAR receptor agonist",-0.40929,-0.998,0.474,1314,0.723,"pterostilbene",0.324221658325915,0.140861702705469,FALSE +"A549","Pearson.est","progesterone receptor agonist",-0.3593,-0.87,0.661,1345,0.793,"melengestrol.acetate, danazol",0.17979854051436,0.100726812682396,FALSE +"A549","Pearson.est","proteasome inhibitor",0.42683,1.23,0.195,104,0.606,"MG.132, carfilzomib",0.709965388637482,0.217527375833714,FALSE +"A549","Pearson.est","protein synthesis inhibitor",-0.29716,-0.723,0.808,1415,0.869,"florfenicol, azomycin..2.nitroimidazole.",0.0925886392254138,0.0609802235513335,FALSE +"A549","Pearson.est","protein tyrosine kinase inhibitor",-0.32571,-0.78,0.773,1031,0.895,"NVP.TAE226, BMS.599626, mubritinib",0.111820506081675,0.048176964684088,FALSE +"A549","Pearson.est","RAF inhibitor",0.29052,0.812,0.72,86,0.91,"vemurafenib, AZ.628, LGX818",0.142667503568732,0.0409586076789064,FALSE +"A549","Pearson.est","RET tyrosine kinase inhibitor",-0.31235,-0.749,0.771,906,0.869,"apatinib, sunitinib, cabozantinib, sorafenib",0.112945621949043,0.0609802235513335,FALSE +"A549","Pearson.est","retinoid receptor agonist",-0.54094,-1.31,0.153,1292,0.676,"adapalene, fenretinide, bexarotene",0.815308569182401,0.170053304058364,FALSE +"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.31125,-0.763,0.791,783,0.868,"clofarabine, fludarabine, cytarabine, cladribine, pentostatin",0.101823516502323,0.0614802748235081,FALSE +"A549","Pearson.est","serotonin receptor agonist",-0.54747,-1.32,0.135,1247,0.697,"ipsapirone, aripiprazole",0.869666231504994,0.156767221901991,FALSE +"A549","Pearson.est","serotonin receptor antagonist",-0.45843,-1.09,0.364,1375,0.697,"lurasidone, aripiprazole",0.438898616350944,0.156767221901991,FALSE +"A549","Pearson.est","sodium channel blocker",-0.42922,-1.06,0.403,973,0.718,"cibenzoline, oxcarbazepine, A.803467, triamterene, quinidine, ajmaline, lappaconite",0.39469495385889,0.1438755557577,FALSE +"A549","Pearson.est","src inhibitor",0.36658,1.07,0.352,16,0.724,"dasatinib, saracatinib",0.453457336521869,0.140261433802853,FALSE +"A549","Pearson.est","sterol demethylase inhibitor",-0.7094,-1.74,0.0183,1179,0.653,"terconazole, ketoconazole",1.73754891026957,0.185086818724926,FALSE +"A549","Pearson.est","TGF beta receptor inhibitor",-0.37927,-0.937,0.525,1391,0.764,"adaprev",0.279840696594043,0.11690664142431,FALSE +"A549","Pearson.est","thymidylate synthase inhibitor",0.39084,1.07,0.331,325,0.724,"capecitabine, doxifluridine, ftorafur, carmofur",0.480172006224281,0.140261433802853,FALSE +"A549","Pearson.est","topoisomerase inhibitor",-0.39578,-0.948,0.532,920,0.762,"voreloxin, valrubicin, camptothecin, nemorubicin, etoposide.phosphate, SN.38, rubitecan, fleroxacin, TAS.103, genz.644282, dexrazoxane, irinotecan",0.274088367704952,0.1180450286604,FALSE +"A549","Pearson.est","tubulin polymerization inhibitor",0.22916,0.689,0.889,365,0.878,"mebendazole, CYT.997, paclitaxel, BNC105, vincristine, vindesine, epothilone.b, verubulin, fosbretabulin, taltobulin, dolastatin.10, vinorelbine, podophyllotoxin",0.0510982390297863,0.0565054840938974,FALSE +"A549","Pearson.est","tyrosine kinase inhibitor",-0.24234,-0.589,0.955,1031,0.981,"NVP.TAE226, sunitinib, cabozantinib, BMS.599626, mubritinib, GTP.14564, sorafenib, UNC2250",0.0199966284162537,0.0083309926200515,FALSE +"A549","Pearson.est","VEGFR inhibitor",-0.30074,-0.737,0.775,1069,0.868,"sunitinib, cabozantinib, ENMD.2076, PD.173074, linifanib, MK.2461, axitinib, lenvatinib, lucitanib, sorafenib, MGCD.265, tivozanib, KI.8751",0.11069829749369,0.0614802748235081,FALSE +"A549","Pearson.est","vitamin D receptor agonist",-0.55644,-1.34,0.148,1257,0.688,"maxacalcitol, paricalcitol, tacalcitol",0.829738284605043,0.162411561764489,FALSE +"HCC44","Pearson.est","EGFR inhibitor",0.46107,1.28,0.168,181,0.676,"pelitinib, canertinib, vandetanib, XL.647, BMS.690514, afatinib, brigatinib, erlotinib, rociletinib, dacomitinib, AZD8931, neratinib, lapatinib, poziotinib, CUDC.101, PD.168393, AEE788",0.774690718274137,0.170053304058364,FALSE +"HCC44","Pearson.est","Abl kinase inhibitor",-0.5691,-1.4,0.102,1185,0.613,"KW.2449, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.991399828238082,0.212539525481585,FALSE +"HCC44","Pearson.est","acetylcholine receptor agonist",-0.40697,-0.989,0.484,1055,0.825,"nicotine, nefiracetam, pilocarpine",0.315154638355588,0.0835460514500749,FALSE +"HCC44","Pearson.est","acetylcholine receptor antagonist",-0.4726,-1.16,0.304,986,0.685,"dicycloverine, iododexetimide, methscopolamine",0.517126416391246,0.164309428507574,FALSE +"HCC44","Pearson.est","adenosine receptor antagonist",-0.56326,-1.35,0.133,873,0.523,"sulmazole, CGS.15943, istradefylline, MRS.1220, SCH.58261",0.876148359032914,0.281498311132726,FALSE +"HCC44","Pearson.est","adrenergic receptor agonist",-0.47732,-1.15,0.297,1117,0.683,"A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.527243550682788,0.165579296318467,FALSE +"HCC44","Pearson.est","adrenergic receptor antagonist",0.38565,1.1,0.31,266,0.661,"prazosin, vincamine, RS.17053, practolol, dihydroergocristine, atenolol...., levobunolol, imiloxan, idazoxan",0.508638306165727,0.17979854051436,FALSE +"HCC44","Pearson.est","AKT inhibitor",-0.44724,-1.09,0.354,998,0.698,"triciribine, uprosertib, ONC201, A.674563, CCT128930",0.450996737974212,0.156144577376839,FALSE +"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.33558,-0.806,0.713,1234,0.858,"alectinib, AP26113, DMH1",0.146910470148134,0.0665127121512946,FALSE +"HCC44","Pearson.est","androgen receptor antagonist",-0.59204,-1.45,0.0876,1015,0.672,"nilutamide, flutamide, bicalutamide",1.05749589383192,0.172630726946175,FALSE +"HCC44","Pearson.est","antioxidant",-0.52167,-1.25,0.193,1350,0.647,"benfotiamine, trolox",0.714442690992226,0.1890957193313,FALSE +"HCC44","Pearson.est","AP inhibitor",0.51529,1.44,0.115,50,0.586,"birinapant, GDC.0152",0.939302159646388,0.232102383981909,FALSE +"HCC44","Pearson.est","ATPase inhibitor",0.25835,0.764,0.737,2,0.906,"k.strophanthidin",0.132532512140949,0.0428718023231869,FALSE +"HCC44","Pearson.est","Aurora kinase inhibitor",-0.6182,-1.5,0.0533,1160,0.707,"aurora.a.inhibitor.i, CCT129202, AMG900, KW.2449, barasertib.HQPA, ENMD.2076, SNS.314, AT.9283, barasertib, MK.8745, PF.03814735, hesperadin, tozasertib",1.27327279097343,0.150580586203101,FALSE +"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.49996,-1.22,0.235,1080,0.628,"tilmicosin, josamycin, radezolid, dirithromycin",0.628932137728264,0.202040356262804,FALSE +"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",0.4762,1.39,0.0972,126,0.558,"novobiocin, finafloxacin, sarafloxacin",1.01233373507373,0.253365801062421,FALSE +"HCC44","Pearson.est","BCL inhibitor",-0.40969,-0.976,0.497,1059,0.829,"gossypol, ABT.737",0.303643611266668,0.0814454694497265,FALSE +"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.56179,-1.39,0.0964,1211,0.587,"flumatinib, nilotinib, imatinib, ponatinib, tozasertib",1.01592296609717,0.231361898752386,FALSE +"HCC44","Pearson.est","benzodiazepine receptor agonist",0.21665,0.608,0.92,53,0.967,"ZK.93423, gamma.aminobutyric.acid",0.0362121726544447,0.0145735259169983,FALSE +"HCC44","Pearson.est","bromodomain inhibitor",-0.56718,-1.38,0.112,1056,0.565,"JQ1...., PFI.1, I.BET151, bromosporine",0.950781977329818,0.247951552180562,FALSE +"HCC44","Pearson.est","calcium channel blocker",-0.55503,-1.37,0.117,1171,0.547,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",0.931814138253838,0.262012673666569,FALSE +"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.42657,-1.04,0.434,760,0.739,"RS.504393, MK.0812, SB.225002, PF.04136309, navarixin",0.362510270487489,0.131355561605174,FALSE +"HCC44","Pearson.est","CDK inhibitor",-0.38451,-0.927,0.564,1067,0.86,"BMS.265246, JNJ.7706621, NU6027, abemaciclib, ribociclib, kenpaullone, indirubin, R547, arcyriaflavin.a",0.248720896016658,0.0655015487564323,FALSE +"HCC44","Pearson.est","CHK inhibitor",0.53261,1.57,0.0574,102,0.712,"SCH.900776, LY2603618, CHIR.124",1.24108810760203,0.147520006363144,FALSE +"HCC44","Pearson.est","cyclooxygenase inhibitor",-0.33995,-0.824,0.689,1021,0.903,"tepoxalin, metoxibutropate, indoprofen, piroxicam, FK.3311, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.161780778092374,0.0443122496864942,FALSE +"HCC44","Pearson.est","cytochrome P450 inhibitor",0.23167,0.669,0.825,254,0.997,"PF.4981517, morin, eplerenone",0.0835460514500749,0.00130484168834428,FALSE +"HCC44","Pearson.est","DNA alkylating agent",-0.38584,-0.932,0.549,946,0.872,"carmustine, streptozotocin, temozolomide, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.260427655549908,0.0594835150674328,FALSE +"HCC44","Pearson.est","DNA inhibitor",-0.38984,-0.952,0.495,1079,0.855,"pibenzimol, carboplatin, metronidazole, melphalan, primaquine, tirapazamine, mechlorethamine",0.305394801066431,0.0680338852718274,FALSE +"HCC44","Pearson.est","DNA methyltransferase inhibitor",0.32476,0.952,0.502,202,0.864,"decitabine, SGI.1027, azacitidine",0.299296282854981,0.0634862575211067,FALSE +"HCC44","Pearson.est","DNA polymerase inhibitor",0.31806,0.925,0.489,990,0.865,"cephalomannine, menadione, famciclovir, adefovir.dipivoxil, idoxuridine, trifluridine, cidofovir, foscarnet",0.31069114087638,0.0629838925351858,FALSE +"HCC44","Pearson.est","DNA synthesis inhibitor",-0.33522,-0.809,0.705,709,0.889,"cyclocytidine, anisomycin, nelarabine, cisplatin, azodicarbonamide, artesunate, estramustine.phosphate, enocitabine, CB.10.277, altretamine, mitomycin.c",0.151810883008601,0.0510982390297863,FALSE +"HCC44","Pearson.est","dopamine receptor antagonist",-0.36871,-0.894,0.589,645,0.883,"ziprasidone, clebopride, acetophenazine, piperacetazine, oxiperomide, domperidone, raclopride, amisulpride, paliperidone, nemonapride, UH.232...., lurasidone, mesoridazine",0.229884705212898,0.0540392964224314,FALSE +"HCC44","Pearson.est","estrogen receptor agonist",0.44247,1.27,0.183,28,0.6,"levonorgestrel, PPT",0.737548910269571,0.221848749616356,FALSE +"HCC44","Pearson.est","estrogen receptor antagonist",-0.72554,-1.77,0.00759,1284,0.487,"toremifene, fulvestrant, danazol",2.11975822410452,0.312471038785366,FALSE +"HCC44","Pearson.est","FGFR inhibitor",-0.57576,-1.41,0.102,972,0.646,"orantinib, PD.173074, lenvatinib, MK.2461, erdafitinib, lucitanib",0.991399828238082,0.189767482004916,FALSE +"HCC44","Pearson.est","FLT3 inhibitor",-0.58477,-1.41,0.0854,1126,0.646,"midostaurin, sorafenib, KW.2449, ENMD.2076, tandutinib, TG.101348, GTP.14564, ponatinib, quizartinib, tozasertib",1.06854212931099,0.189767482004916,FALSE +"HCC44","Pearson.est","glucocorticoid receptor agonist",0.39227,1.13,0.272,292,0.663,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, triamcinolone.acetonide, ciclesonide, desonide, fluocinolone.acetonide, prednisolone, halcinonide, fludroxycortide",0.565431095965801,0.178486471595227,FALSE +"HCC44","Pearson.est","glutamate receptor antagonist",-0.25259,-0.607,0.916,1291,0.935,"MTPG, IEM1754",0.0381045263321496,0.0291883891274822,FALSE +"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.51643,-1.24,0.215,1152,0.641,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, indirubin, CHIR.98014",0.667561540084395,0.193141970481183,FALSE +"HCC44","Pearson.est","growth factor receptor inhibitor",-0.51003,-1.23,0.219,817,0.633,"AZD3463, lestaurtinib, GSK1904529A, GSK1838705A, GW.441756",0.659555885159882,0.198596289982645,FALSE +"HCC44","Pearson.est","HCV inhibitor",0.28531,0.814,0.662,60,0.866,"daclatasvir",0.1791420105603,0.0624821079826534,FALSE +"HCC44","Pearson.est","HDAC inhibitor",-0.48732,-1.19,0.253,960,0.643,"entinostat, scriptaid, PCI.24781, dacinostat, panobinostat, AR.42, givinostat, trichostatin.a, vorinostat, resminostat, RG2833, R306465, M.344, RGFP966",0.596879478824182,0.191789027075778,FALSE +"HCC44","Pearson.est","histamine receptor antagonist",-0.3457,-0.846,0.649,1193,0.907,"BF2.649, lafutidine, tecastemizole, epinastine",0.187755303199631,0.0423927129399047,FALSE +"HCC44","Pearson.est","HMGCR inhibitor",-0.51603,-1.25,0.213,1245,0.647,"lovastatin, fluvastatin",0.671620396561262,0.1890957193313,FALSE +"HCC44","Pearson.est","HSP inhibitor",0.55166,1.55,0.0376,283,0.513,"BIIB021, KW.2478, alvespimycin, SNX.5422, NVP.AUY922, SNX.2112, ganetespib, VER.49009",1.42481215507234,0.289882634888184,FALSE +"HCC44","Pearson.est","JAK inhibitor",-0.34455,-0.844,0.68,889,0.89,"WHI.P154, lestaurtinib, LY2784544, CEP.33779, AZD1480, TG.101348, AT.9283, TG.101209, tozasertib",0.167491087293764,0.0506099933550872,FALSE +"HCC44","Pearson.est","KIT inhibitor",-0.4698,-1.13,0.317,1126,0.704,"midostaurin, sorafenib, tandutinib, imatinib, lenvatinib, KI.8751, masitinib",0.498940737782249,0.152427340857888,FALSE +"HCC44","Pearson.est","MDM inhibitor",-0.55641,-1.35,0.137,1119,0.523,"serdemetan, RITA",0.863279432843593,0.281498311132726,FALSE +"HCC44","Pearson.est","MEK inhibitor",0.65847,1.91,0.0128,173,0.372,"trametinib, selumetinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, AZD8330, cobimetinib, TAK.733, PD.0325901, PD.198306",1.89279003035213,0.429457060118102,FALSE +"HCC44","Pearson.est","MET inhibitor",-0.66107,-1.6,0.0318,1407,0.933,"NVP.BVU972, AMG458",1.49757288001557,0.0301183562535,FALSE +"HCC44","Pearson.est","microtubule inhibitor",-0.27795,-0.672,0.894,831,0.925,"cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.0486624812040823,0.0338582672609674,FALSE +"HCC44","Pearson.est","mTOR inhibitor",-0.37076,-0.895,0.607,708,0.903,"OSI.027, AZD8055, NVP.BEZ235, deforolimus, voxtalisib, torin.2, PKI.179, MLN0128, sirolimus, XL388, GSK2126458, LY303511, PF.04691502, torin.1, LY3023414, ku.0063794, AZD2014, WYE.354, SB.2343",0.216811308924742,0.0443122496864942,FALSE +"HCC44","Pearson.est","NFkB pathway inhibitor",-0.28038,-0.677,0.856,1255,0.937,"EVP4593, betulinic.acid",0.0675262353228468,0.0282604091122217,FALSE +"HCC44","Pearson.est","opioid receptor agonist",-0.49043,-1.19,0.246,840,0.643,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.609064892896621,0.191789027075778,FALSE +"HCC44","Pearson.est","p38 MAPK inhibitor",-0.45882,-1.11,0.342,968,0.7,"SB.242235, TAK.715, SB.239063, skepinone.l",0.465973893943865,0.154901959985743,FALSE +"HCC44","Pearson.est","PARP inhibitor",-0.63667,-1.54,0.0413,1207,0.693,"AG.14361, niraparib, PJ.34, E7449",1.3840499483436,0.159266765388193,FALSE +"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.45476,-1.1,0.368,1088,0.698,"linifanib, crenolanib, axitinib, sorafenib, tandutinib, imatinib, lenvatinib, ponatinib, KI.8751, masitinib",0.434152181326482,0.156144577376839,FALSE +"HCC44","Pearson.est","phosphatase inhibitor",-0.54518,-1.29,0.158,914,0.648,"AS.1949490, sodium.stibogluconate, bis.maltolato.oxovanadium.IV., CID.5458317, alexidine, BVT.948, GSK2830371",0.801342913045577,0.188424994129407,FALSE +"HCC44","Pearson.est","phosphodiesterase inhibitor",0.28442,0.827,0.676,1039,0.894,"cilostamide, EMD.53998, enoximone, avanafil, anagrelide, papaverine, trequinsin, zardaverine, GSK256066, YM.976",0.170053304058364,0.0486624812040823,FALSE +"HCC44","Pearson.est","PI3K inhibitor",-0.35464,-0.863,0.632,724,0.898,"TG100.115, NVP.BEZ235, pilaralisib, voxtalisib, YM.201636, PKI.179, BGT226, TG.100713, GSK2126458, LY303511, AZD6482, PF.04691502, GDC.0941, LY3023414, CH5132799, CUDC.907, SB.2343",0.199282921717615,0.0467236633326956,FALSE +"HCC44","Pearson.est","PLK inhibitor",-0.28469,-0.691,0.825,632,0.939,"GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.0835460514500749,0.0273344077338891,FALSE +"HCC44","Pearson.est","potassium channel blocker",0.21721,0.621,0.918,196,1,"dofetilide, mepivacaine",0.0371573187987575,0,FALSE +"HCC44","Pearson.est","PPAR receptor agonist",-0.32995,-0.806,0.722,1246,0.858,"pterostilbene",0.141462802430361,0.0665127121512946,FALSE +"HCC44","Pearson.est","progesterone receptor agonist",-0.33542,-0.818,0.702,1131,0.893,"dienogest, melengestrol.acetate, danazol",0.153662887870195,0.0491485411114536,FALSE +"HCC44","Pearson.est","proteasome inhibitor",0.4499,1.26,0.166,87,0.543,"carfilzomib, MG.132",0.779891911959945,0.265200170411153,FALSE +"HCC44","Pearson.est","protein synthesis inhibitor",0.31401,0.859,0.627,153,0.883,"homoharringtonine, clofoctol, cycloheximide, bruceantin, chloramphenicol.palmitate, anguidine",0.202732459169284,0.0540392964224314,FALSE +"HCC44","Pearson.est","protein tyrosine kinase inhibitor",-0.27246,-0.665,0.871,593,0.916,"CP.724714, tyrphostin.A9, PP.121, rheochrysidin, NVP.TAE226, mubritinib, BMS.599626",0.0599818449923368,0.0381045263321496,FALSE +"HCC44","Pearson.est","RAF inhibitor",-0.24677,-0.609,0.924,1001,0.949,"CEP.32496, RAF265, sorafenib, TAK.632",0.0343280287798933,0.0227337875727074,FALSE +"HCC44","Pearson.est","RET tyrosine kinase inhibitor",0.30878,0.863,0.609,19,0.933,"vandetanib",0.215382707367125,0.0301183562535,FALSE +"HCC44","Pearson.est","retinoid receptor agonist",-0.43435,-1.06,0.409,1180,0.719,"fenretinide, adapalene, bexarotene",0.388276691992658,0.143271109617117,FALSE +"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.32116,-0.783,0.718,843,0.858,"cytarabine, fludarabine, clofarabine, cladribine, pentostatin",0.1438755557577,0.0665127121512946,FALSE +"HCC44","Pearson.est","serotonin receptor agonist",-0.59191,-1.46,0.0702,1293,0.744,"ipsapirone, aripiprazole",1.15366288787019,0.128427064454121,FALSE +"HCC44","Pearson.est","serotonin receptor antagonist",-0.52382,-1.28,0.173,1349,0.637,"lurasidone, aripiprazole",0.761953896871205,0.19586056766465,FALSE +"HCC44","Pearson.est","sodium channel blocker",-0.43813,-1.06,0.388,991,0.719,"cibenzoline, oxcarbazepine, A.803467, triamterene, ajmaline, quinidine, lappaconite",0.411168274405793,0.143271109617117,FALSE +"HCC44","Pearson.est","src inhibitor",0.35406,0.966,0.469,17,0.9,"saracatinib, dasatinib",0.328827157284917,0.0457574905606751,FALSE +"HCC44","Pearson.est","sterol demethylase inhibitor",-0.64766,-1.56,0.0425,1216,0.811,"terconazole, ketoconazole",1.37161106994969,0.090979145788844,FALSE +"HCC44","Pearson.est","TGF beta receptor inhibitor",-0.35969,-0.883,0.619,1379,0.883,"adaprev",0.208309350979882,0.0540392964224314,FALSE +"HCC44","Pearson.est","thymidylate synthase inhibitor",0.43364,1.23,0.229,210,0.532,"capecitabine, doxifluridine, ftorafur",0.640164517660112,0.274088367704952,FALSE +"HCC44","Pearson.est","topoisomerase inhibitor",-0.33399,-0.796,0.719,886,0.856,"valrubicin, nemorubicin, etoposide.phosphate, camptothecin, voreloxin, rubitecan, SN.38, fleroxacin, dexrazoxane, genz.644282, TAS.103, irinotecan",0.143271109617117,0.0675262353228468,FALSE +"HCC44","Pearson.est","tubulin polymerization inhibitor",0.17442,0.514,0.991,218,0.979,"mebendazole, paclitaxel, BNC105, vindesine, CYT.997",0.00392634551472468,0.00921730819686218,FALSE +"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.18608,-0.45,0.994,834,0.991,"AMG.208, apatinib, NVP.TAE226, tyrphostin.AG.99, sunitinib, mubritinib, cabozantinib, BMS.599626, sorafenib, GTP.14564, UNC2250",0.00261361560268669,0.00392634551472468,FALSE +"HCC44","Pearson.est","VEGFR inhibitor",-0.28876,-0.695,0.842,972,0.952,"orantinib, sunitinib, RAF265, PD.173074, cabozantinib, linifanib, axitinib, sorafenib, ENMD.2076, lenvatinib, MK.2461, lucitanib, tivozanib, MGCD.265, KI.8751",0.0746879085003505,0.0213630516155257,FALSE +"HCC44","Pearson.est","vitamin D receptor agonist",-0.45837,-1.11,0.355,793,0.7,"alfacalcidol, ercalcitriol, maxacalcitol, paricalcitol, tacalcitol",0.449771646944906,0.154901959985743,FALSE +"H1703","Pearson.est","EGFR inhibitor",0.39102,1.12,0.301,220,0.625,"pelitinib, canertinib, vandetanib, XL.647, brigatinib, afatinib, erlotinib, BMS.690514, rociletinib, dacomitinib, AZD8931, neratinib, PD.168393, CUDC.101, poziotinib, lapatinib",0.521433504406157,0.204119982655925,FALSE +"H1703","Pearson.est","Abl kinase inhibitor",-0.5569,-1.33,0.142,1093,0.554,"metatinib, flumatinib, nilotinib, KW.2449, imatinib, ponatinib, tozasertib",0.847711655616944,0.25649023527157,FALSE +"H1703","Pearson.est","acetylcholine receptor agonist",-0.40463,-0.976,0.499,1095,0.8,"nicotine, nefiracetam, pilocarpine",0.30189945437661,0.0969100130080564,FALSE +"H1703","Pearson.est","acetylcholine receptor antagonist",-0.47397,-1.15,0.33,985,0.687,"dicycloverine, iododexetimide, methscopolamine",0.481486060122112,0.16304326294045,FALSE +"H1703","Pearson.est","adenosine receptor antagonist",-0.54651,-1.3,0.159,1005,0.56,"istradefylline, CGS.15943, MRS.1220, SCH.58261",0.798602875679548,0.2518119729938,FALSE +"H1703","Pearson.est","adrenergic receptor agonist",-0.38734,-0.933,0.531,835,0.822,"metaraminol, ritodrine, midodrine, A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.274905478918531,0.0851281824599496,FALSE +"H1703","Pearson.est","adrenergic receptor antagonist",0.45186,1.31,0.17,227,0.474,"prazosin, vincamine, RS.17053, practolol, imiloxan, dihydroergocristine, levobunolol, atenolol...., idazoxan",0.769551078621726,0.324221658325915,FALSE +"H1703","Pearson.est","AKT inhibitor",-0.46532,-1.13,0.323,1195,0.681,"ONC201, uprosertib, A.674563, CCT128930",0.490797477668897,0.166852888087215,FALSE +"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.25949,-0.623,0.894,906,0.923,"NVP.TAE684, CEP.37440, AZD3463, AP26113, alectinib, DMH1",0.0486624812040823,0.0347982989740879,FALSE +"H1703","Pearson.est","androgen receptor antagonist",-0.55134,-1.33,0.15,853,0.554,"nilutamide, flutamide, bicalutamide",0.823908740944319,0.25649023527157,FALSE +"H1703","Pearson.est","antioxidant",-0.49249,-1.21,0.24,1332,0.627,"benfotiamine, trolox",0.619788758288394,0.202732459169284,FALSE +"H1703","Pearson.est","AP inhibitor",0.60439,1.7,0.0574,38,0.49,"birinapant, GDC.0152",1.24108810760203,0.309803919971486,FALSE +"H1703","Pearson.est","ATPase inhibitor",0.29462,0.815,0.646,147,0.85,"k.strophanthidin, digitoxin, ouabain",0.189767482004916,0.0705810742857073,FALSE +"H1703","Pearson.est","Aurora kinase inhibitor",-0.62369,-1.51,0.0622,1137,0.707,"barasertib.HQPA, KW.2449, CCT129202, ENMD.2076, AMG900, SNS.314, aurora.a.inhibitor.i, PF.03814735, MK.8745, AT.9283, barasertib, hesperadin, tozasertib",1.20620961530918,0.150580586203101,FALSE +"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.54825,-1.35,0.132,836,0.674,"azithromycin, azalomycin.b, valnemulin, tilmicosin, josamycin, radezolid, dirithromycin",0.87942606879415,0.17134010346468,FALSE +"H1703","Pearson.est","bacterial DNA gyrase inhibitor",0.54456,1.58,0.0368,133,0.506,"finafloxacin, sarafloxacin, novobiocin",1.43415218132648,0.295849483160201,FALSE +"H1703","Pearson.est","BCL inhibitor",-0.52318,-1.28,0.164,1131,0.522,"gossypol, ABT.737",0.785156151952302,0.282329496997738,FALSE +"H1703","Pearson.est","Bcr.Abl kinase inhibitor",-0.53866,-1.29,0.177,1093,0.527,"metatinib, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.752026733638193,0.278189384787453,FALSE +"H1703","Pearson.est","benzodiazepine receptor agonist",0.24645,0.72,0.826,49,0.917,"ZK.93423, gamma.aminobutyric.acid",0.0830199526796178,0.0376306643299789,FALSE +"H1703","Pearson.est","bromodomain inhibitor",-0.62594,-1.53,0.0587,1121,1,"PFI.1, JQ1...., bromosporine, I.BET151",1.23136189875239,0,FALSE +"H1703","Pearson.est","calcium channel blocker",-0.6211,-1.51,0.0626,1257,0.707,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.20342566678957,0.150580586203101,FALSE +"H1703","Pearson.est","CC chemokine receptor antagonist",-0.41835,-1.01,0.463,712,0.82,"RS.504393, MK.0812, SB.225002, PF.04136309, navarixin",0.334419008982047,0.0861861476162833,FALSE +"H1703","Pearson.est","CDK inhibitor",-0.40481,-0.988,0.499,916,0.798,"palbociclib, AZD5438, indisulam, BMS.265246, JNJ.7706621, ribociclib, abemaciclib, kenpaullone, NU6027, indirubin, R547, arcyriaflavin.a",0.30189945437661,0.0979971086492706,FALSE +"H1703","Pearson.est","CHK inhibitor",0.49102,1.37,0.13,107,0.517,"SCH.900776, CHIR.124, LY2603618",0.886056647693163,0.286509456906058,FALSE +"H1703","Pearson.est","cyclooxygenase inhibitor",-0.30235,-0.72,0.821,943,0.87,"metoxibutropate, curcumin, tepoxalin, piroxicam, indoprofen, FK.3311, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.0856568428805592,0.0604807473813815,FALSE +"H1703","Pearson.est","cytochrome P450 inhibitor",0.32296,0.935,0.49,323,0.884,"PF.4981517, morin, eplerenone, metyrapone",0.309803919971486,0.0535477349869269,FALSE +"H1703","Pearson.est","DNA alkylating agent",-0.377,-0.907,0.581,800,0.85,"streptozotocin, cisplatin, temozolomide, ifosfamide, carmustine, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.235823867609669,0.0705810742857073,FALSE +"H1703","Pearson.est","DNA inhibitor",-0.40224,-0.96,0.503,1009,0.811,"carmustine, carboplatin, tirapazamine, pibenzimol, metronidazole, primaquine, melphalan, mechlorethamine",0.298432014944073,0.090979145788844,FALSE +"H1703","Pearson.est","DNA methyltransferase inhibitor",-0.32096,-0.778,0.737,1247,0.875,"disulfiram, RG108",0.132532512140949,0.0579919469776868,FALSE +"H1703","Pearson.est","DNA polymerase inhibitor",0.30556,0.879,0.597,1008,0.829,"cephalomannine, famciclovir, menadione, adefovir.dipivoxil, idoxuridine, trifluridine, cidofovir, foscarnet",0.224025668870631,0.0814454694497265,FALSE +"H1703","Pearson.est","DNA synthesis inhibitor",-0.32107,-0.778,0.734,920,0.875,"artesunate, azodicarbonamide, estramustine.phosphate, altretamine, CB.10.277, enocitabine, mitomycin.c",0.134303940083929,0.0579919469776868,FALSE +"H1703","Pearson.est","dopamine receptor antagonist",-0.33677,-0.807,0.709,1041,0.886,"UH.232...., paliperidone, nemonapride, lurasidone, mesoridazine",0.149353764816933,0.0525662781129492,FALSE +"H1703","Pearson.est","estrogen receptor agonist",0.5161,1.44,0.1,26,0.616,"levonorgestrel, PPT",1,0.210419287835575,FALSE +"H1703","Pearson.est","estrogen receptor antagonist",-0.69799,-1.67,0.0218,1265,1,"toremifene, danazol, fulvestrant",1.6615435063954,0,FALSE +"H1703","Pearson.est","FGFR inhibitor",-0.59329,-1.45,0.0751,1011,0.546,"orantinib, PD.173074, MK.2461, lenvatinib, erdafitinib, lucitanib",1.12436006299583,0.262807357295263,FALSE +"H1703","Pearson.est","FLT3 inhibitor",-0.57423,-1.39,0.133,1115,0.606,"sunitinib, tandutinib, KW.2449, ENMD.2076, GTP.14564, TG.101348, sorafenib, ponatinib, quizartinib, tozasertib",0.876148359032914,0.217527375833714,FALSE +"H1703","Pearson.est","glucocorticoid receptor agonist",0.46603,1.29,0.201,286,0.452,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, fluocinolone.acetonide, ciclesonide, triamcinolone.acetonide, prednisolone, halcinonide, fludroxycortide, desonide",0.696803942579511,0.344861565188618,FALSE +"H1703","Pearson.est","glutamate receptor antagonist",0.26803,0.755,0.758,154,0.906,"SIB.1757, latrepirdine, kynurenic.acid",0.120330794367946,0.0428718023231869,FALSE +"H1703","Pearson.est","glycogen synthase kinase inhibitor",-0.54867,-1.31,0.161,1218,0.568,"kenpaullone, LY2090314, GSK.3.inhibitor.IX, indirubin, CHIR.98014",0.79317412396815,0.245651664288981,FALSE +"H1703","Pearson.est","growth factor receptor inhibitor",-0.52426,-1.27,0.195,819,0.52,"GSK1904529A, lestaurtinib, AZD3463, GSK1838705A, GW.441756",0.709965388637482,0.283996656365201,FALSE +"H1703","Pearson.est","HCV inhibitor",0.33574,0.933,0.494,63,0.825,"daclatasvir",0.306273051076353,0.0835460514500749,FALSE +"H1703","Pearson.est","HDAC inhibitor",-0.54463,-1.33,0.152,1043,0.554,"PCI.24781, scriptaid, entinostat, dacinostat, panobinostat, AR.42, trichostatin.a, vorinostat, givinostat, RG2833, R306465, resminostat, M.344, RGFP966",0.818156412055227,0.25649023527157,FALSE +"H1703","Pearson.est","histamine receptor antagonist",-0.31412,-0.766,0.748,1139,0.874,"lafutidine, BF2.649, tecastemizole, epinastine",0.126098402135539,0.058488567365597,FALSE +"H1703","Pearson.est","HMGCR inhibitor",-0.40881,-0.992,0.488,1151,0.812,"fluvastatin, lovastatin",0.311580177997289,0.0904439707588247,FALSE +"H1703","Pearson.est","HSP inhibitor",0.50524,1.37,0.146,180,0.517,"BIIB021, KW.2478, SNX.5422, SNX.2112, alvespimycin",0.835647144215563,0.286509456906058,FALSE +"H1703","Pearson.est","JAK inhibitor",-0.33512,-0.825,0.687,1246,0.915,"TG.101348, AT.9283, TG.101209, tozasertib",0.16304326294045,0.0385789059335517,FALSE +"H1703","Pearson.est","KIT inhibitor",-0.43721,-1.06,0.4,1115,0.785,"sunitinib, tandutinib, imatinib, lenvatinib, sorafenib, KI.8751, masitinib",0.397940008672038,0.105130343254747,FALSE +"H1703","Pearson.est","MDM inhibitor",-0.53279,-1.29,0.178,1134,0.527,"serdemetan, RITA",0.749579997691106,0.278189384787453,FALSE +"H1703","Pearson.est","MEK inhibitor",0.63658,1.79,0.0195,174,0.682,"selumetinib, trametinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, cobimetinib, AZD8330, TAK.733, PD.198306, PD.0325901",1.70996538863748,0.166215625343521,FALSE +"H1703","Pearson.est","MET inhibitor",-0.63129,-1.5,0.0581,1402,0.624,"NVP.BVU972, AMG458",1.23582386760967,0.204815410317576,FALSE +"H1703","Pearson.est","microtubule inhibitor",0.1509,0.438,0.996,1231,0.996,"secnidazole, triclabendazole, vinflunine, vinblastine, podophyllotoxin, cytochalasin.b, cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.00174066157630127,0.00174066157630127,FALSE +"H1703","Pearson.est","mTOR inhibitor",-0.42557,-1.03,0.424,773,0.827,"PF.05212384, NVP.BEZ235, deforolimus, temsirolimus, voxtalisib, OSI.027, PKI.179, torin.2, MLN0128, LY303511, sirolimus, XL388, LY3023414, torin.1, GSK2126458, PF.04691502, ku.0063794, WYE.354, AZD2014, SB.2343",0.372634143407267,0.0824944904474534,FALSE +"H1703","Pearson.est","NFkB pathway inhibitor",-0.33785,-0.812,0.697,1309,0.916,"EVP4593, betulinic.acid",0.156767221901991,0.0381045263321496,FALSE +"H1703","Pearson.est","opioid receptor agonist",-0.41862,-1,0.457,809,0.818,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.34008379993015,0.087246696328677,FALSE +"H1703","Pearson.est","p38 MAPK inhibitor",-0.46367,-1.11,0.343,1322,0.7,"SB.239063, skepinone.l",0.464705879957229,0.154901959985743,FALSE +"H1703","Pearson.est","PARP inhibitor",-0.60621,-1.46,0.0803,1169,0.583,"AG.14361, PJ.34, niraparib, E7449",1.09528445472132,0.234331445240986,FALSE +"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.47221,-1.14,0.305,1067,0.684,"crenolanib, sunitinib, linifanib, tandutinib, axitinib, imatinib, lenvatinib, sorafenib, ponatinib, KI.8751, masitinib",0.515700160653214,0.164943898279884,FALSE +"H1703","Pearson.est","phosphatase inhibitor",-0.49677,-1.2,0.237,850,0.599,"sodium.stibogluconate, bis.maltolato.oxovanadium.IV., AS.1949490, CID.5458317, BVT.948, alexidine, GSK2830371",0.625251653989896,0.222573177610689,FALSE +"H1703","Pearson.est","phosphodiesterase inhibitor",0.24131,0.668,0.897,1101,0.945,"cilostamide, EMD.53998, enoximone, avanafil, anagrelide, papaverine, trequinsin, zardaverine, GSK256066, YM.976",0.0472075569559079,0.0245681914907371,FALSE +"H1703","Pearson.est","PI3K inhibitor",-0.42619,-1.02,0.426,736,0.823,"PI.828, TG100.115, PF.05212384, pilaralisib, NVP.BEZ235, YM.201636, voxtalisib, TG.100713, PI3K.IN.2, PKI.179, BGT226, AZD6482, LY303511, GDC.0941, LY3023414, GSK2126458, PF.04691502, CUDC.907, CH5132799, SB.2343",0.370590400897281,0.0846001647877302,FALSE +"H1703","Pearson.est","PLK inhibitor",-0.27315,-0.651,0.892,676,0.931,"GSK461364, BI.2536, NMS.1286937, volasertib, rigosertib, GW.843682X",0.0496351456238769,0.0310503190186574,FALSE +"H1703","Pearson.est","potassium channel blocker",0.32007,0.922,0.498,238,0.792,"dofetilide, oleoylethanolamide, mepivacaine",0.302770657240282,0.101274818410506,FALSE +"H1703","Pearson.est","PPAR receptor agonist",-0.37307,-0.9,0.584,1310,0.843,"pterostilbene",0.233587152887601,0.0741724253752577,FALSE +"H1703","Pearson.est","progesterone receptor agonist",-0.31491,-0.753,0.784,1301,0.859,"melengestrol.acetate, danazol",0.105683937315562,0.0660068361687577,FALSE +"H1703","Pearson.est","proteasome inhibitor",0.3938,1.12,0.326,109,0.625,"MG.132, carfilzomib",0.486782399932061,0.204119982655925,FALSE +"H1703","Pearson.est","protein synthesis inhibitor",0.29014,0.836,0.595,175,0.861,"cycloheximide, clofoctol, homoharringtonine, chloramphenicol.palmitate, bruceantin, anguidine",0.22548303427145,0.0649968485463452,FALSE +"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.3074,-0.728,0.781,987,0.876,"NVP.TAE226, mubritinib, BMS.599626",0.1073489661227,0.0574958938319193,FALSE +"H1703","Pearson.est","RAF inhibitor",-0.26152,-0.634,0.899,1278,0.93,"sorafenib, TAK.632",0.0462403082667712,0.0315170514460649,FALSE +"H1703","Pearson.est","RET tyrosine kinase inhibitor",-0.35206,-0.852,0.639,1110,0.889,"cabozantinib, sunitinib, sorafenib",0.1944991418416,0.0510982390297863,FALSE +"H1703","Pearson.est","retinoid receptor agonist",-0.5551,-1.34,0.138,1287,0.65,"adapalene, fenretinide, bexarotene",0.860120913598763,0.187086643357144,FALSE +"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.33057,-0.794,0.728,776,0.886,"hydroxyurea, clofarabine, cytarabine, fludarabine, cladribine, pentostatin",0.137868620686963,0.0525662781129492,FALSE +"H1703","Pearson.est","serotonin receptor agonist",-0.57415,-1.42,0.0905,1271,0.575,"ipsapirone, aripiprazole",1.0433514207948,0.24033215531037,FALSE +"H1703","Pearson.est","serotonin receptor antagonist",-0.49512,-1.2,0.263,1369,0.599,"lurasidone, aripiprazole",0.580044251510242,0.222573177610689,FALSE +"H1703","Pearson.est","sodium channel blocker",-0.38709,-0.947,0.519,1004,0.815,"cibenzoline, A.803467, quinidine, ajmaline, triamterene, lappaconite",0.284832642151542,0.0888423912600234,FALSE +"H1703","Pearson.est","src inhibitor",0.37515,1.03,0.391,17,0.746,"dasatinib, saracatinib",0.407823242604133,0.127261172527331,FALSE +"H1703","Pearson.est","sterol demethylase inhibitor",-0.66846,-1.62,0.0147,1156,0.864,"terconazole, ketoconazole",1.83268266525182,0.0634862575211067,FALSE +"H1703","Pearson.est","TGF beta receptor inhibitor",-0.36029,-0.875,0.605,1386,0.868,"adaprev",0.218244625347531,0.0614802748235081,FALSE +"H1703","Pearson.est","thymidylate synthase inhibitor",0.46395,1.31,0.181,208,0.474,"capecitabine, doxifluridine, ftorafur",0.742321425130815,0.324221658325915,FALSE +"H1703","Pearson.est","topoisomerase inhibitor",-0.31615,-0.765,0.744,891,0.859,"voreloxin, valrubicin, etoposide.phosphate, camptothecin, nemorubicin, rubitecan, SN.38, fleroxacin, TAS.103, genz.644282, dexrazoxane, irinotecan",0.128427064454121,0.0660068361687577,FALSE +"H1703","Pearson.est","tubulin polymerization inhibitor",0.22723,0.665,0.91,355,0.906,"mebendazole, CYT.997, BNC105, paclitaxel, vincristine, vindesine, taltobulin, verubulin, epothilone.b, vinorelbine, oxibendazole",0.0409586076789064,0.0428718023231869,FALSE +"H1703","Pearson.est","tyrosine kinase inhibitor",-0.24615,-0.59,0.931,1110,0.932,"cabozantinib, sunitinib, mubritinib, BMS.599626, GTP.14564, sorafenib, UNC2250",0.0310503190186574,0.0305840876460186,FALSE +"H1703","Pearson.est","VEGFR inhibitor",-0.33446,-0.81,0.713,1110,0.9,"cabozantinib, sunitinib, linifanib, PD.173074, axitinib, ENMD.2076, MK.2461, lenvatinib, sorafenib, MGCD.265, lucitanib, tivozanib, KI.8751",0.146910470148134,0.0457574905606751,FALSE +"H1703","Pearson.est","vitamin D receptor agonist",-0.59758,-1.46,0.0734,1254,0.583,"maxacalcitol, paricalcitol, tacalcitol",1.13430394008393,0.234331445240986,FALSE +"H1299","Pearson.est","EGFR inhibitor",0.40182,1.18,0.237,183,0.555,"pelitinib, canertinib, vandetanib, BMS.690514, erlotinib, brigatinib, XL.647, afatinib, rociletinib, AZD8931, PD.168393, dacomitinib, poziotinib, lapatinib, neratinib, icotinib",0.625251653989896,0.255707016877324,FALSE +"H1299","Pearson.est","Abl kinase inhibitor",-0.51717,-1.27,0.179,1164,0.545,"nilotinib, flumatinib, KW.2449, imatinib, ponatinib, tozasertib",0.747146969020107,0.263603497723358,FALSE +"H1299","Pearson.est","acetylcholine receptor agonist",-0.43348,-1.05,0.41,960,0.778,"xanomeline, nicotine, nefiracetam, pilocarpine",0.387216143280265,0.109020403010311,FALSE +"H1299","Pearson.est","acetylcholine receptor antagonist",-0.49852,-1.22,0.222,852,0.588,"dicycloverine, diphemanil, iododexetimide, methscopolamine",0.653647025549361,0.230622673923862,FALSE +"H1299","Pearson.est","adenosine receptor antagonist",-0.53912,-1.3,0.153,958,0.528,"istradefylline, CGS.15943, MRS.1220, SCH.58261",0.815308569182401,0.277366077466188,FALSE +"H1299","Pearson.est","adrenergic receptor agonist",-0.36595,-0.873,0.644,996,0.915,"A61603, isoxsuprine, clenbuterol, isoetharine, buphenine, norepinephrine",0.191114132640188,0.0385789059335517,FALSE +"H1299","Pearson.est","adrenergic receptor antagonist",0.3726,1.08,0.345,186,0.606,"prazosin, vincamine, RS.17053, practolol, imiloxan, levobunolol, atenolol....",0.462180904926726,0.217527375833714,FALSE +"H1299","Pearson.est","AKT inhibitor",-0.50255,-1.21,0.228,1101,0.59,"triciribine, ONC201, CCT128930, uprosertib, A.674563",0.642065152999546,0.229147988357856,FALSE +"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.24882,-0.607,0.93,888,0.935,"CEP.37440, NVP.TAE684, AZD3463, AP26113, alectinib, DMH1",0.0315170514460649,0.0291883891274822,FALSE +"H1299","Pearson.est","androgen receptor antagonist",-0.56584,-1.37,0.121,899,0.506,"nilutamide, flutamide, bicalutamide",0.91721462968355,0.295849483160201,FALSE +"H1299","Pearson.est","antioxidant",-0.48629,-1.19,0.257,1310,0.592,"benfotiamine, trolox",0.590066876668705,0.22767829327708,FALSE +"H1299","Pearson.est","AP inhibitor",0.59545,1.75,0.0233,27,0.288,"birinapant, GDC.0152",1.63264407897398,0.540607512240769,FALSE +"H1299","Pearson.est","ATPase inhibitor",0.33368,0.976,0.482,114,0.548,"k.strophanthidin, ouabain, digitoxin",0.31695296176115,0.261219441515631,FALSE +"H1299","Pearson.est","Aurora kinase inhibitor",-0.65789,-1.59,0.033,1158,1,"CCT129202, CCT137690, aurora.a.inhibitor.i, KW.2449, barasertib.HQPA, PF.03814735, AMG900, ENMD.2076, MK.8745, AT.9283, SNS.314, barasertib, hesperadin, tozasertib",1.48148606012211,0,FALSE +"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.58512,-1.42,0.0837,948,0.531,"valnemulin, azalomycin.b, tilmicosin, josamycin, radezolid, dirithromycin",1.07727454200674,0.274905478918531,FALSE +"H1299","Pearson.est","bacterial DNA gyrase inhibitor",0.51149,1.49,0.0711,212,0.386,"sarafloxacin, finafloxacin, novobiocin, sparfloxacin",1.14813039927023,0.413412695328245,FALSE +"H1299","Pearson.est","BCL inhibitor",-0.52948,-1.31,0.159,1206,0.561,"gossypol, ABT.737",0.798602875679548,0.251037138743839,FALSE +"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.48467,-1.19,0.257,1164,0.592,"nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.590066876668705,0.22767829327708,FALSE +"H1299","Pearson.est","benzodiazepine receptor agonist",0.23773,0.68,0.885,118,0.853,"gamma.aminobutyric.acid, ZK.93423, eprinomectin",0.0530567293021746,0.069050968832477,FALSE +"H1299","Pearson.est","bromodomain inhibitor",-0.76933,-1.87,0.00386,1128,0.207,"OTX015, PFI.1, JQ1...., bromosporine, I.BET151",2.41341269532824,0.684029654543082,TRUE +"H1299","Pearson.est","calcium channel blocker",-0.63135,-1.52,0.052,1237,0.485,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.2839966563652,0.314258261397736,FALSE +"H1299","Pearson.est","CC chemokine receptor antagonist",-0.52527,-1.26,0.209,1098,0.521,"SB.225002, PF.04136309, navarixin",0.679853713888946,0.283162276700476,FALSE +"H1299","Pearson.est","CDK inhibitor",-0.53221,-1.28,0.159,1077,0.549,"palbociclib, BMS.265246, AZD5438, NU6027, indisulam, JNJ.7706621, kenpaullone, abemaciclib, ribociclib, indirubin, R547, arcyriaflavin.a",0.798602875679548,0.260427655549908,FALSE +"H1299","Pearson.est","CHK inhibitor",0.52934,1.5,0.0935,187,0.497,"SCH.900776, CHIR.124, LY2603618, LY2606368",1.02918838912748,0.303643611266668,FALSE +"H1299","Pearson.est","cyclooxygenase inhibitor",-0.30719,-0.758,0.763,921,0.915,"metoxibutropate, indoprofen, curcumin, FK.3311, tepoxalin, piroxicam, pterostilbene, naproxen, aspirin, FR.122047, tryptanthrin",0.11747546204512,0.0385789059335517,FALSE +"H1299","Pearson.est","cytochrome P450 inhibitor",0.35685,1.02,0.367,178,0.519,"PF.4981517, morin, eplerenone",0.435333935747911,0.284832642151542,FALSE +"H1299","Pearson.est","DNA alkylating agent",-0.37621,-0.905,0.571,855,0.893,"temozolomide, ifosfamide, streptozotocin, carmustine, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.243363891754152,0.0491485411114536,FALSE +"H1299","Pearson.est","DNA inhibitor",-0.43159,-1.06,0.399,934,0.804,"oxaliplatin, carmustine, valrubicin, carboplatin, metronidazole, tirapazamine, pibenzimol, melphalan, primaquine, mechlorethamine",0.399027104313252,0.0947439512515487,FALSE +"H1299","Pearson.est","DNA methyltransferase inhibitor",-0.40118,-0.973,0.492,1060,0.836,"fdcyd, RG108, disulfiram",0.30803489723264,0.0777937225609836,FALSE +"H1299","Pearson.est","DNA polymerase inhibitor",-0.29744,-0.718,0.809,890,0.903,"idoxuridine, foscarnet, cidofovir, trifluridine",0.0920514783877277,0.0443122496864942,FALSE +"H1299","Pearson.est","DNA synthesis inhibitor",-0.34056,-0.806,0.723,704,0.933,"floxuridine, cisplatin, cyclocytidine, azodicarbonamide, estramustine.phosphate, artesunate, anisomycin, altretamine, CB.10.277, enocitabine, mitomycin.c",0.140861702705469,0.0301183562535,FALSE +"H1299","Pearson.est","dopamine receptor antagonist",-0.43672,-1.05,0.401,1187,0.778,"nemonapride, paliperidone, UH.232...., lurasidone, mesoridazine",0.396855627379818,0.109020403010311,FALSE +"H1299","Pearson.est","estrogen receptor agonist",0.44188,1.28,0.194,39,0.638,"PPT, levonorgestrel",0.712198270069774,0.195179321278838,FALSE +"H1299","Pearson.est","estrogen receptor antagonist",-0.65624,-1.58,0.0422,1238,0.771,"toremifene, danazol, fulvestrant",1.37468754903833,0.112945621949043,FALSE +"H1299","Pearson.est","FGFR inhibitor",-0.55111,-1.32,0.158,1127,0.568,"PD.173074, MK.2461, lenvatinib, erdafitinib, lucitanib",0.801342913045577,0.245651664288981,FALSE +"H1299","Pearson.est","FLT3 inhibitor",-0.62995,-1.53,0.0555,964,0.535,"midostaurin, TG.02, lestaurtinib, pacritinib, sunitinib, tandutinib, KW.2449, TG.101348, ENMD.2076, ponatinib, GTP.14564, sorafenib, quizartinib, tozasertib",1.25570701687732,0.271646217978772,FALSE +"H1299","Pearson.est","glucocorticoid receptor agonist",0.37584,1.09,0.327,258,0.655,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, fluocinolone.acetonide, triamcinolone.acetonide, ciclesonide, halcinonide, desonide",0.485452247339714,0.183758700008217,FALSE +"H1299","Pearson.est","glutamate receptor antagonist",0.30568,0.871,0.599,162,0.63,"SIB.1757, latrepirdine, kynurenic.acid, CGP.37849",0.222573177610689,0.200659450546418,FALSE +"H1299","Pearson.est","glycogen synthase kinase inhibitor",-0.56931,-1.38,0.1,1215,0.515,"LY2090314, GSK.3.inhibitor.IX, kenpaullone, CHIR.98014, indirubin",1,0.288192770958809,FALSE +"H1299","Pearson.est","growth factor receptor inhibitor",-0.53339,-1.3,0.145,913,0.528,"GSK1904529A, AZD3463, lestaurtinib, GSK1838705A, GW.441756",0.838631997765025,0.277366077466188,FALSE +"H1299","Pearson.est","HCV inhibitor",-0.25735,-0.627,0.902,1291,0.949,"narlaprevir",0.0447934624580583,0.0227337875727074,FALSE +"H1299","Pearson.est","HDAC inhibitor",-0.57037,-1.4,0.104,1075,0.499,"PCI.24781, entinostat, scriptaid, panobinostat, dacinostat, AR.42, trichostatin.a, givinostat, vorinostat, RG2833, resminostat, R306465, M.344, RGFP966",0.98296666070122,0.30189945437661,FALSE +"H1299","Pearson.est","histamine receptor antagonist",-0.25117,-0.618,0.934,998,0.941,"cyproheptadine, tecastemizole, BF2.649, lafutidine, epinastine",0.0296531237699066,0.0264103765727431,FALSE +"H1299","Pearson.est","HMGCR inhibitor",-0.26443,-0.646,0.887,1033,0.947,"fluvastatin, lovastatin",0.0520763801682736,0.0236500209967266,FALSE +"H1299","Pearson.est","HSP inhibitor",0.42534,1.22,0.21,307,0.555,"BIIB021, KW.2478, SNX.2112, SNX.5422, alvespimycin, NVP.AUY922, ganetespib, VER.49009",0.677780705266081,0.255707016877324,FALSE +"H1299","Pearson.est","JAK inhibitor",-0.38867,-0.934,0.542,989,0.854,"LY2784544, TG.02, AZD1480, lestaurtinib, pacritinib, TG.101348, AT.9283, TG.101209, tozasertib",0.266000713461613,0.068542129310995,FALSE +"H1299","Pearson.est","KIT inhibitor",-0.40371,-0.983,0.497,1112,0.837,"sunitinib, tandutinib, lenvatinib, imatinib, sorafenib, KI.8751, masitinib",0.303643611266668,0.07727454200674,FALSE +"H1299","Pearson.est","MDM inhibitor",-0.63653,-1.54,0.0485,1223,0.605,"serdemetan, RITA",1.31425826139774,0.218244625347531,FALSE +"H1299","Pearson.est","MEK inhibitor",0.61207,1.79,0.027,201,0.485,"selumetinib, trametinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, cobimetinib, AZD8330, TAK.733, PD.198306, PD.0325901",1.56863623584101,0.314258261397736,FALSE +"H1299","Pearson.est","MET inhibitor",-0.60239,-1.45,0.0782,1377,0.503,"NVP.BVU972, AMG458",1.10679324694015,0.298432014944073,FALSE +"H1299","Pearson.est","microtubule inhibitor",-0.29532,-0.728,0.826,846,0.923,"cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.0830199526796178,0.0347982989740879,FALSE +"H1299","Pearson.est","mTOR inhibitor",-0.42663,-1.03,0.43,720,0.78,"deforolimus, NVP.BEZ235, PF.05212384, OSI.027, voxtalisib, AZD8055, WYE.125132, PKI.179, torin.2, MLN0128, sirolimus, LY3023414, torin.1, PF.04691502, XL388, LY303511, GSK2126458, ku.0063794, WYE.354, SB.2343, AZD2014",0.366531544420413,0.10790539730952,FALSE +"H1299","Pearson.est","NFkB pathway inhibitor",-0.3907,-0.937,0.557,1378,0.869,"betulinic.acid, EVP4593",0.254144804826271,0.0609802235513335,FALSE +"H1299","Pearson.est","opioid receptor agonist",-0.32585,-0.796,0.736,714,0.93,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.133122185662501,0.0315170514460649,FALSE +"H1299","Pearson.est","p38 MAPK inhibitor",-0.48156,-1.15,0.293,893,0.663,"TAK.715, talmapimod, SB.242235, SB.239063, skepinone.l",0.533132379645891,0.178486471595227,FALSE +"H1299","Pearson.est","PARP inhibitor",-0.62871,-1.5,0.0713,1185,0.478,"AG.14361, PJ.34, E7449, niraparib",1.14691047014813,0.320572103387881,FALSE +"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.45659,-1.1,0.357,1080,0.736,"linifanib, sunitinib, crenolanib, tandutinib, axitinib, lenvatinib, imatinib, ponatinib, sorafenib, KI.8751, masitinib",0.447331783887807,0.133122185662501,FALSE +"H1299","Pearson.est","phosphatase inhibitor",-0.40751,-0.991,0.475,1012,0.841,"BVT.948, CID.5458317, alexidine, GSK2830371",0.323306390375133,0.0752040042020878,FALSE +"H1299","Pearson.est","phosphodiesterase inhibitor",0.3491,0.97,0.468,946,0.523,"cilostamide, EMD.53998, enoximone, avanafil, anagrelide, papaverine, zardaverine, trequinsin, GSK256066, YM.976",0.329754146925876,0.281498311132726,FALSE +"H1299","Pearson.est","PI3K inhibitor",-0.36473,-0.884,0.627,850,0.914,"PI3K.IN.2, YM.201636, TG.100713, PKI.179, BGT226, AZD6482, LY3023414, PF.04691502, LY303511, GDC.0941, GSK2126458, CH5132799, CUDC.907, SB.2343",0.202732459169284,0.0390538042661686,FALSE +"H1299","Pearson.est","PLK inhibitor",-0.39669,-0.963,0.517,701,0.835,"GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.286509456906058,0.0783135245163979,FALSE +"H1299","Pearson.est","potassium channel blocker",0.34636,1.02,0.429,144,0.519,"dofetilide, mepivacaine",0.367542707815276,0.284832642151542,FALSE +"H1299","Pearson.est","PPAR receptor agonist",-0.31593,-0.771,0.75,877,0.931,"GW.501516, pterostilbene",0.1249387366083,0.0310503190186574,FALSE +"H1299","Pearson.est","progesterone receptor agonist",-0.34016,-0.828,0.698,1323,0.935,"melengestrol.acetate, danazol",0.156144577376839,0.0291883891274822,FALSE +"H1299","Pearson.est","proteasome inhibitor",0.36132,1.05,0.367,107,0.555,"MG.132, carfilzomib",0.435333935747911,0.255707016877324,FALSE +"H1299","Pearson.est","protein synthesis inhibitor",-0.29467,-0.719,0.813,1246,0.918,"thiostrepton, florfenicol, azomycin..2.nitroimidazole.",0.0899094544059319,0.0371573187987575,FALSE +"H1299","Pearson.est","protein tyrosine kinase inhibitor",-0.32649,-0.787,0.749,1070,0.925,"NVP.TAE226, BMS.599626, mubritinib",0.125518182300534,0.0338582672609674,FALSE +"H1299","Pearson.est","RAF inhibitor",-0.30453,-0.746,0.771,1336,0.915,"sorafenib, TAK.632",0.112945621949043,0.0385789059335517,FALSE +"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.3392,-0.823,0.687,1112,0.924,"sunitinib, cabozantinib, sorafenib",0.16304326294045,0.0343280287798933,FALSE +"H1299","Pearson.est","retinoid receptor agonist",-0.64042,-1.55,0.0549,1290,0.708,"adapalene, fenretinide, bexarotene",1.26042765554991,0.149966742310231,FALSE +"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.35204,-0.846,0.658,947,0.923,"clofarabine, fludarabine, cladribine, pentostatin",0.181774106386044,0.0347982989740879,FALSE +"H1299","Pearson.est","serotonin receptor agonist",-0.60398,-1.48,0.0667,1257,0.475,"ipsapirone, aripiprazole",1.17587416608345,0.323306390375133,FALSE +"H1299","Pearson.est","serotonin receptor antagonist",-0.54234,-1.32,0.136,1379,0.568,"lurasidone, aripiprazole",0.866461091629782,0.245651664288981,FALSE +"H1299","Pearson.est","sodium channel blocker",-0.45029,-1.1,0.347,1248,0.736,"quinidine, triamterene, ajmaline, lappaconite",0.459670525209126,0.133122185662501,FALSE +"H1299","Pearson.est","src inhibitor",0.40397,1.23,0.201,7,0.627,"dasatinib, saracatinib",0.696803942579511,0.202732459169284,FALSE +"H1299","Pearson.est","sterol demethylase inhibitor",-0.5831,-1.41,0.0973,1004,0.513,"terconazole, ketoconazole",1.01188715973165,0.289882634888184,FALSE +"H1299","Pearson.est","TGF beta receptor inhibitor",-0.31274,-0.762,0.792,1343,0.927,"adaprev",0.101274818410506,0.0329202658555029,FALSE +"H1299","Pearson.est","thymidylate synthase inhibitor",0.36479,1.06,0.336,184,0.588,"capecitabine, doxifluridine, ftorafur",0.473660722610156,0.230622673923862,FALSE +"H1299","Pearson.est","topoisomerase inhibitor",-0.42285,-1.03,0.441,939,0.78,"beta.lapachone, camptothecin, nemorubicin, 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+visNetwork + + + + + + + +
+
+
+ + + + diff --git a/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_mean_results.csv b/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..291c61e --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_mean_results.csv @@ -0,0 +1,83 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"estrogen receptor antagonist",0.8851,1.14384832424972,0.00170439338368609,"HCC827, HCC95, H1650, H2009, H2126, H3255, H1299, H1703, H460, H520",10,3,"HCC827, HCC95, H1299",0.0113464066409016 +"KIT inhibitor",0.839466666666667,0.803198326928631,0.19121708254354,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.307447073893535 +"PDGFR tyrosine kinase receptor inhibitor",0.8026,0.784486711168519,0.357883032418245,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.481088666529444 +"microtubule inhibitor",0.770533333333333,0.903426008249127,0.114816218863349,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.208310356372865 +"FLT3 inhibitor",0.677733333333333,0.959667983260481,0.137914163518786,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.23079513078654 +"VEGFR inhibitor",0.595733333333333,0.863282809700164,0.607982672900286,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.744098196683932 +"RET tyrosine kinase inhibitor",0.573428571428571,1.32970243717479,0.0239655681574714,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",14,2,"H2009, H3255",0.0701848781754521 +"tyrosine kinase inhibitor",0.556133333333333,0.869785841183799,0.690775001579834,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.820596210897299 +"vitamin D receptor agonist",0.549642857142857,1.36886952837525,0.0475892932624293,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, HCC44, H1299, H1703, H460, H520",14,2,"H2126, H1299",0.118252183258158 +"phosphatase inhibitor",0.4786,1.01344094196808,0.325808489249211,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.446884199423928 +"FGFR inhibitor",0.4696,1.13571467744827,0.120120437869359,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.209571827772073 +"histamine receptor antagonist",0.416133333333333,0.951023198355079,0.67544344869976,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.81450533519677 +"ATPase inhibitor",0.411533333333333,1.17289342267419,0.0385494299994575,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.105368441998517 +"tubulin polymerization inhibitor",0.402333333333333,1.32053661531248,0.00227791502989198,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, H2009",0.0133420737465102 +"cytochrome P450 inhibitor",0.393076923076923,1.35978763424897,0.00344947591532525,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H520",13,1,"H358",0.018857135003778 +"CC chemokine receptor antagonist",0.3636,1.07077720771943,0.326988438602874,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.446884199423928 +"androgen receptor antagonist",0.329,1.55017123478113,0.000888251145708769,"HCC827, HCC95, H1650, H2126, A549, HCC15, H460, H520",8,1,"H520",0.00809295488312434 +"acetylcholine receptor agonist",0.317272727272727,1.21997853185284,0.0830351587096072,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, H1703, H460, H520",11,0,"",0.174586743953533 +"MET inhibitor",0.299642857142857,1.35854920395267,0.00456728950628658,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",14,2,"H3255, H520",0.0234073587197187 +"RAF inhibitor",0.279333333333333,1.18965196991549,0.0897258113656997,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.179451622731399 +"PI3K inhibitor",0.269933333333333,0.873835753336703,0.970160276568316,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.994414283482524 +"acetylcholine receptor antagonist",0.255583333333333,1.46268218497472,0.000574967513496775,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, H1703, H460, H520",12,2,"HCC827, H520",0.00667744342406333 +"HCV inhibitor",0.252333333333333,1.66280977063924,0.0404494935445278,"HCC95, H1650, H2126",3,1,"H2126",0.106995434537138 +"Bcr.Abl kinase inhibitor",0.242866666666667,1.31318608553323,0.00946312735091422,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.0369512591797603 +"CDK inhibitor",0.2346,1.05436018513599,0.515173034480734,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.643245580591472 +"protein tyrosine kinase inhibitor",0.2198,1.28920120340354,0.0150872673834341,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.0526342477945311 +"phosphodiesterase inhibitor",0.215866666666667,1.18091767383715,0.103406399754913,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC827",0.192711926815974 +"protein synthesis inhibitor",0.215666666666667,1.1380993972827,0.223548542544777,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.345867556390032 +"Abl kinase inhibitor",0.211666666666667,1.19977745952362,0.0967920359681462,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.184580161613674 +"AKT inhibitor",0.202066666666667,1.11403984711157,0.294622577041667,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.431411630668156 +"sodium channel blocker",0.202066666666667,0.997834259546048,0.76415742175529,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.829002800604204 +"Aurora kinase inhibitor",0.193466666666667,1.39324604875842,0.000651457895030568,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, HCC15",0.00667744342406333 +"JAK inhibitor",0.1906,1.05944829308196,0.517734247793136,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.643245580591472 +"PPAR receptor agonist",0.180333333333333,1.15114551643135,0.324169860550375,"HCC827, HCC95, H1650, H1975, H2126, H3255, A549, HCC15, H520",9,0,"",0.446884199423928 +"topoisomerase inhibitor",0.174133333333333,1.22948914284794,0.0374414601257941,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H520",0.105368441998517 +"thymidylate synthase inhibitor",0.172666666666667,1.33068755947908,0.00683375180867201,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0311315360172836 +"proteasome inhibitor",0.1566,1.66280661189792,0.0004488483204824,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,6,"H1650, H2009, H2126, HCC15, HCC44, H520",0.00613426037992614 +"calcium channel blocker",0.1564,1.00755147333949,0.749350522627746,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.829002800604204 +"adrenergic receptor agonist",0.156066666666667,1.01618062698846,0.738996105873,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.829002800604204 +"adrenergic receptor antagonist",0.1464,0.96060968734891,0.876466860201191,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.933380292681788 +"retinoid receptor agonist",0.142733333333333,1.49692625386951,0.00113915341974756,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC827, H1650, H460",0.00849187094720905 +"HDAC inhibitor",0.140933333333333,1.19780826432916,0.116857029184778,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H520",0.208310356372865 +"glutamate receptor antagonist",0.1316,1.03153331086716,0.717593262624976,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.820596210897299 +"DNA polymerase inhibitor",0.121133333333333,1.11883203556634,0.281802030716572,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.42014120943198 +"p38 MAPK inhibitor",0.112133333333333,1.28435085697387,0.0197801780415804,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H520",0.0623836384388304 +"dopamine receptor antagonist",0.104066666666667,1.00620961084278,0.768344059096579,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.829002800604204 +"NFkB pathway inhibitor",0.101266666666667,1.01840796390856,0.720523502251287,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.820596210897299 +"estrogen receptor agonist",0.0958666666666666,1.23278105266488,0.0539026687462208,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.130000554035003 +"growth factor receptor inhibitor",0.0930714285714285,1.33328117320136,0.00758242775850614,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",14,2,"HCC95, H1975",0.0327241619051318 +"PARP inhibitor",0.0758,1.31580698758269,0.0105458707427728,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0393073364048803 +"progesterone receptor agonist",0.0749333333333334,1.22358387339736,0.0602338598054067,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.141119328686953 +"sterol demethylase inhibitor",0.0470769230769232,1.44773653574229,0.000410104063120403,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, HCC44, H1299, H1703, H520",13,4,"HCC827, HCC95, H1975, H2126",0.00613426037992614 +"DNA inhibitor",0.0252666666666666,0.926540220903756,0.959470890947323,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.994414283482524 +"adenosine receptor antagonist",0.0247142857142857,1.360399004171,0.00654636876144202,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",14,2,"H358, H520",0.0311315360172836 +"opioid receptor agonist",0.0243076923076923,1.22585401418871,0.088645632297815,"HCC827, HCC95, H1650, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",13,0,"",0.179451622731399 +"cyclooxygenase inhibitor",0.0159333333333333,0.877131157049313,0.993011081052835,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.995803359462341 +"ribonucleotide reductase inhibitor",0,1.08591001995035,0.50378480371297,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.643245580591472 +"DNA alkylating agent",-0.0186666666666666,0.858306028229581,0.995803359462341,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.995803359462341 +"mTOR inhibitor",-0.0252666666666666,1.09878448859681,0.454162966796078,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.591132750432991 +"serotonin receptor antagonist",-0.0269333333333333,0.911887717607716,0.957515272450734,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.994414283482524 +"ALK tyrosine kinase receptor inhibitor",-0.0446666666666667,1.16079736552489,0.25201862318328,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.382694946315351 +"glycogen synthase kinase inhibitor",-0.0522,1.21404366831322,0.0961651329110097,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.184580161613674 +"PLK inhibitor",-0.0701333333333333,1.52403969139664,0.000999606405274106,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, H2009, H460, H520",0.00819677252324767 +"MDM inhibitor",-0.0708000000000001,1.66942363972986,1.56270817326498e-05,"HCC827, HCC95, H1650, H1975, H2126, H3255, A549, HCC15, H1703, H520",10,4,"HCC95, H1650, A549, HCC15",0.000640710351038642 +"benzodiazepine receptor agonist",-0.0820666666666666,1.02639072667748,0.707471534520014,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.820596210897299 +"BCL inhibitor",-0.0991333333333333,1.1177867076547,0.321780236635162,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.446884199423928 +"src inhibitor",-0.103733333333333,1.27221451844898,0.0233276406645266,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.0701848781754521 +"DNA synthesis inhibitor",-0.113333333333333,1.08893904241479,0.419663100419937,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.555038294103788 +"DNA methyltransferase inhibitor",-0.117923076923077,1.18734714535798,0.206687310061696,"HCC827, HCC95, H1650, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",13,1,"H1650",0.325929988943443 +"TGF beta receptor inhibitor",-0.134428571428571,1.47191124911617,4.93800000911267e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",14,2,"H2126, HCC15",0.0010122900018681 +"antioxidant",-0.154461538461539,1.47953413925829,0.00930092235482115,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, HCC15, H1299, H1703, H460, H520",13,3,"HCC95, H358, H1299",0.0369512591797603 +"EGFR inhibitor",-0.168266666666667,1.29604301442433,0.0192857874899016,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.0623836384388304 +"HMGCR inhibitor",-0.237428571428571,1.72200288977137,0.075956984258917,"HCC95, H1650, H2126, A549, HCC15, H1703, H460",7,2,"HCC95, A549",0.163907176558716 +"bacterial DNA gyrase inhibitor",-0.255428571428571,1.13860776756162,0.17306815712699,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1703, H460, H520",14,1,"H1703",0.283831777688264 +"bacterial 50S ribosomal subunit inhibitor",-0.304466666666667,1.12757558293806,0.133955195667609,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.228840125932165 +"bromodomain inhibitor",-0.314769230769231,1.50190352296933,3.03863454928732e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, HCC44, H1703, H460, H520",13,4,"HCC95, HCC15, H1703, H520",0.000830560110138535 +"glucocorticoid receptor agonist",-0.3748,1.2018185149419,0.041973067144815,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.107555984558588 +"MEK inhibitor",-0.406666666666667,1.33239942888581,0.00179882056502098,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, H1703",0.0113464066409016 +"AP inhibitor",-0.482846153846154,1.63842718514606,2.24458832074295e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, H1299, H1703, H460, H520",13,5,"HCC95, H1975, H2126, A549, H460",1.84056242300922e-05 +"HSP inhibitor",-0.5138,1.11503089002695,0.0733558848355029,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, HCC44, H520",0.162572501527331 +"potassium channel blocker",-0.621,1.06096756869293,0.0651150256396577,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, H1703, H460, H520",12,0,"",0.148317558401442 +"CHK inhibitor",-0.700214285714286,1.34756236782007,0.0154051456959603,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",14,4,"HCC95, H1650, H2126, A549",0.0526342477945311 diff --git a/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_results.csv b/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_results.csv new file mode 100644 index 0000000..a6fe0fd --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_results.csv @@ -0,0 +1,1156 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"HCC827","Pearson.est","EGFR inhibitor",-0.58091,-1.56,0.0895,1183,0.46,"neratinib, CGP.52411, BMS.599626, GW.583340, OSI.420, PD.153035, PD.168393, CNX.2006, tucatinib, afatinib, poziotinib, BMS.690514, CP.724714, erlotinib, gefitinib, XL.647, lapatinib, canertinib, AZD8931, pelitinib, dacomitinib, rociletinib",1.04817696468409,0.337242168318426,FALSE +"HCC827","Pearson.est","Abl kinase inhibitor",-0.19255,-0.518,0.959,274,0.971,"imatinib, GZD824, tozasertib, bafetinib, ponatinib, flumatinib, nilotinib, dasatinib, KW.2449, bosutinib, metatinib, ZM.306416",0.0181813928293364,0.0127807700919951,FALSE +"HCC827","Pearson.est","acetylcholine receptor agonist",0.44648,1.18,0.254,33,0.853,"tremorine",0.595166283380062,0.069050968832477,FALSE +"HCC827","Pearson.est","acetylcholine receptor antagonist",0.67072,1.8,0.0166,156,0.2,"darifenacin, dicycloverine",1.77989191195995,0.698970004336019,TRUE +"HCC827","Pearson.est","adenosine receptor antagonist",-0.43307,-1.15,0.275,1208,0.771,"sulmazole, CGS.15943",0.560667306169737,0.112945621949043,FALSE +"HCC827","Pearson.est","adrenergic receptor agonist",0.14296,0.38,1,1232,0.999,"xylazine, buphenine, isoetharine, epinephrine, norepinephrine, methyldopa, ritodrine, oxymetazoline, A61603, midodrine, terbutaline, isoxsuprine, clenbuterol, lidamidine, metaraminol",0,0.000434511774017692,FALSE +"HCC827","Pearson.est","adrenergic receptor antagonist",-0.29568,-0.807,0.655,1261,0.884,"pindolol, propranolol, dronedarone, prazosin",0.183758700008217,0.0535477349869269,FALSE +"HCC827","Pearson.est","AKT inhibitor",-0.2281,-0.62,0.91,1133,0.925,"MK.2206, palomid.529, A.674563",0.0409586076789064,0.0338582672609674,FALSE +"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.25945,-0.711,0.782,1153,0.981,"crizotinib, AP26113, AZD3463, GW.788388",0.106793246940152,0.0083309926200515,FALSE +"HCC827","Pearson.est","androgen receptor antagonist",0.53691,1.45,0.0898,455,0.74,"flutamide, RU.58841, nilutamide, enzalutamide",1.0467236633327,0.130768280269024,FALSE +"HCC827","Pearson.est","antioxidant",-0.23243,-0.629,0.881,919,0.968,"benfotiamine, chlorogenic.acid, mesna, trolox",0.0550240915879521,0.0141246426916063,FALSE +"HCC827","Pearson.est","AP inhibitor",0.35568,0.945,0.485,15,1,"idronoxil",0.314258261397736,0,FALSE +"HCC827","Pearson.est","ATPase inhibitor",0.40984,1.09,0.354,450,0.962,"blebbistatin...., digitoxigenin, oligomycin.a, evodiamine, rabeprazole",0.450996737974212,0.0168249279621871,FALSE +"HCC827","Pearson.est","Aurora kinase inhibitor",-0.30848,-0.85,0.599,928,0.87,"PHA.680632, danusertib, KW.2449, CYC116, ZM.447439, MLN.8054, GSK1070916, MK.5108, TAK.901, PF.03814735, AT.9283, CCT129202",0.222573177610689,0.0604807473813815,FALSE +"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.53637,-1.48,0.104,1198,0.539,"radezolid, valnemulin, azalomycin.b, tilmicosin, tedizolid",0.98296666070122,0.268411234813261,FALSE +"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",-0.31663,-0.854,0.587,1221,0.895,"trovafloxacin, nadifloxacin",0.231361898752386,0.048176964684088,FALSE +"HCC827","Pearson.est","BCL inhibitor",-0.41157,-1.13,0.285,1233,0.764,"navitoclax, TW.37, HA14.1",0.54515513999149,0.11690664142431,FALSE +"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",0.33056,0.89,0.561,539,0.958,"imatinib, GZD824, tozasertib, bafetinib, ponatinib, flumatinib",0.251037138743839,0.0186344909214556,FALSE +"HCC827","Pearson.est","benzodiazepine receptor agonist",0.27498,0.709,0.791,338,1,"piperazine, eprinomectin, bentazepam, CL.218872",0.101823516502323,0,FALSE +"HCC827","Pearson.est","bromodomain inhibitor",0.3364,0.906,0.537,550,0.962,"I.BET151, PFI.1, JQ1....",0.270025714300444,0.0168249279621871,FALSE +"HCC827","Pearson.est","calcium channel blocker",-0.23172,-0.624,0.935,1413,0.946,"fendiline",0.0291883891274822,0.0241088635982073,FALSE +"HCC827","Pearson.est","CC chemokine receptor antagonist",0.37793,0.989,0.434,347,1,"SB.225002, UNBS.5162, PF.04136309",0.362510270487489,0,FALSE +"HCC827","Pearson.est","CDK inhibitor",-0.45914,-1.23,0.213,960,0.778,"arcyriaflavin.a, indisulam, BMS.265246, P276.00, PHA.793887, kenpaullone, aminopurvalanol.a, BMS.387032, AT.7519, R547, indirubin, CR8..R.",0.671620396561262,0.109020403010311,FALSE +"HCC827","Pearson.est","CHK inhibitor",-0.50086,-1.36,0.166,1093,0.633,"LY2606368, CHIR.124, AZD7762, LY2603618",0.779891911959945,0.198596289982645,FALSE +"HCC827","Pearson.est","cyclooxygenase inhibitor",0.35539,0.933,0.53,339,0.987,"naproxen, piroxicam, amfenac, tepoxalin, aspirin, AM.404, suxibuzone, metoxibutropate, acetylsalicylsalicylic.acid, curcumin",0.275724130399211,0.00568284733036327,FALSE +"HCC827","Pearson.est","cytochrome P450 inhibitor",0.49714,1.34,0.166,482,0.66,"clotrimazole, cobicistat, metyrapone, eplerenone",0.779891911959945,0.180456064458131,FALSE +"HCC827","Pearson.est","DNA alkylating agent",0.32822,0.852,0.65,313,1,"cisplatin, TH.302, dianhydrogalactitol, carmustine, estramustine, cyclophosphamide, carboplatin",0.187086643357144,0,FALSE +"HCC827","Pearson.est","DNA inhibitor",0.2113,0.555,0.952,199,1,"carmustine, tirapazamine, mechlorethamine",0.0213630516155257,0,FALSE +"HCC827","Pearson.est","DNA methyltransferase inhibitor",-0.33493,-0.895,0.544,1422,0.847,"fdcyd",0.26440110030182,0.0721165896692931,FALSE +"HCC827","Pearson.est","DNA polymerase inhibitor",0.26901,0.713,0.796,369,1,"cidofovir, famciclovir, foscarnet",0.0990869322623309,0,FALSE +"HCC827","Pearson.est","DNA synthesis inhibitor",0.48775,1.31,0.154,160,0.667,"cisplatin, azodicarbonamide, artesunate, nelarabine, estramustine.phosphate",0.812479279163537,0.175874166083451,FALSE +"HCC827","Pearson.est","dopamine receptor antagonist",0.26614,0.706,0.824,505,1,"lurasidone, isofloxythepin, UH.232...., amisulpride, raclopride, sertindole, acetophenazine",0.0840727883028842,0,FALSE +"HCC827","Pearson.est","estrogen receptor agonist",0.50455,1.36,0.116,161,0.765,"equol, ethinyl.estradiol, estradiol.cypionate",0.935542010773082,0.116338564846382,FALSE +"HCC827","Pearson.est","estrogen receptor antagonist",0.70625,1.91,0.00727,287,0.184,"toremifene, tamoxifen, fulvestrant, raloxifene",2.13846558914096,0.735182176990464,TRUE +"HCC827","Pearson.est","FGFR inhibitor",-0.29486,-0.801,0.692,1083,0.865,"nintedanib, PD.173074, orantinib, AZD4547, MK.2461",0.159893905543242,0.0629838925351858,FALSE +"HCC827","Pearson.est","FLT3 inhibitor",0.31868,0.85,0.632,502,0.969,"tyrphostin.AG.1296, dovitinib, ENMD.2076, sunitinib, tozasertib, gilteritinib, TG.101348, TG.02, ponatinib, sorafenib",0.199282921717615,0.0136762229492347,FALSE +"HCC827","Pearson.est","glucocorticoid receptor agonist",-0.24382,-0.653,0.86,1365,0.969,"rimexolone, methylprednisolone, deflazacort",0.0655015487564323,0.0136762229492347,FALSE +"HCC827","Pearson.est","glutamate receptor antagonist",0.37034,0.967,0.479,274,1,"latrepirdine, felbamate, IEM1754, diazooxonorleucine, MTPG",0.319664486585437,0,FALSE +"HCC827","Pearson.est","glycogen synthase kinase inhibitor",-0.69535,-1.91,0.011,1089,0.42,"kenpaullone, AZD2858, CHIR.99021, indirubin, CHIR.98014",1.95860731484178,0.3767507096021,FALSE +"HCC827","Pearson.est","growth factor receptor inhibitor",-0.43109,-1.19,0.25,1176,0.802,"lestaurtinib, GSK1904529A, AZD3463",0.602059991327962,0.0958256317158365,FALSE +"HCC827","Pearson.est","HDAC inhibitor",-0.45562,-1.24,0.228,1068,0.832,"chidamide, panobinostat, R306465, belinostat, pyroxamide, scriptaid, RG2833, givinostat, SB.939, JNJ.26481585, entinostat, mocetinostat, tacedinaline, resminostat",0.642065152999546,0.0798766737092761,FALSE +"HCC827","Pearson.est","histamine receptor antagonist",0.41266,1.12,0.299,443,0.944,"chloropyramine, tiotidine, cyproheptadine, cimetidine, famotidine, lafutidine, tecastemizole, epinastine, nizatidine, BF2.649, terfenadine",0.52432881167557,0.025028005701931,FALSE +"HCC827","Pearson.est","HSP inhibitor",-0.39156,-1.03,0.399,1346,0.841,"XL888, KW.2478, tanespimycin",0.399027104313252,0.0752040042020878,FALSE +"HCC827","Pearson.est","JAK inhibitor",-0.36523,-0.992,0.435,1088,0.759,"WHI.P154, pacritinib, PRT062070, TG.101209, lestaurtinib, AT.9283, baricitinib",0.361510743045363,0.11975822410452,FALSE +"HCC827","Pearson.est","KIT inhibitor",0.25641,0.665,0.87,312,1,"motesanib, imatinib, masitinib, regorafenib, sunitinib",0.0604807473813815,0,FALSE +"HCC827","Pearson.est","MDM inhibitor",0.28041,0.752,0.739,459,1,"idasanutlin, nutlin.3, AMG.232",0.131355561605174,0,FALSE +"HCC827","Pearson.est","MEK inhibitor",-0.35688,-0.991,0.453,986,0.728,"MEK162, AZD8330, Ro.4987655, PD.318088, TAK.733, U.0126, refametinib, PD.184352, arctigenin",0.343901797987168,0.137868620686963,FALSE +"HCC827","Pearson.est","MET inhibitor",-0.58165,-1.57,0.0763,1099,0.533,"PF.04217903, AMG458, LY2801653, INC.280",1.11747546204512,0.273272790973428,FALSE +"HCC827","Pearson.est","microtubule inhibitor",0.38674,1.03,0.397,472,1,"estramustine.phosphate, triclabendazole, D.64131, vinflunine, colchicine, vinblastine, secnidazole",0.401209493236885,0,FALSE +"HCC827","Pearson.est","mTOR inhibitor",-0.23651,-0.656,0.881,1239,1,"AZD8055, palomid.529, LY3023414, XL388, WYE.125132",0.0550240915879521,0,FALSE +"HCC827","Pearson.est","NFkB pathway inhibitor",0.2226,0.578,0.931,531,1,"parthenolide...., curcumin, bindarit, BAY.11.7082, EVP4593, betulinic.acid",0.0310503190186574,0,FALSE +"HCC827","Pearson.est","opioid receptor agonist",-0.38947,-1.03,0.415,1031,0.841,"ADL5859, spiradoline, salvinorin.a",0.381951903287907,0.0752040042020878,FALSE +"HCC827","Pearson.est","p38 MAPK inhibitor",0.35827,0.953,0.491,365,1,"SB.242235, skepinone.l, CMPD.1",0.308918507877032,0,FALSE +"HCC827","Pearson.est","PARP inhibitor",0.30269,0.797,0.694,465,1,"AZD2461, PJ.34, niraparib, AG.14361",0.158640529545145,0,FALSE +"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.19075,0.507,0.967,502,1,"dovitinib, motesanib, imatinib, masitinib, regorafenib, sunitinib, lenvatinib, linifanib, ponatinib, sorafenib",0.0145735259169983,0,FALSE +"HCC827","Pearson.est","phosphatase inhibitor",0.50091,1.35,0.163,412,0.706,"CID.5458317, bis.maltolato.oxovanadium.IV., GSK2830371, alexidine, BVT.948, mycophenolate.mofetil, sodium.stibogluconate",0.787812395596042,0.151195298948196,FALSE +"HCC827","Pearson.est","phosphodiesterase inhibitor",-0.72191,-1.9,0.00842,1260,0.226,"avanafil, papaverine, EMD.53998, GSK256066, cilostamide, YM.976",2.07468790850035,0.645891560852599,TRUE +"HCC827","Pearson.est","PI3K inhibitor",-0.36476,-1.02,0.414,1107,0.817,"ZSTK.474, GSK2126458, CUDC.907, YM.201636, TG100.115, CH5132799, buparlisib, TG.100713, LY3023414, taselisib, alpelisib",0.382999658879101,0.0877779434675845,FALSE +"HCC827","Pearson.est","PLK inhibitor",-0.62268,-1.67,0.0448,898,0.579,"GW.843682X, rigosertib, BI.2536, NMS.1286937, GSK461364, volasertib",1.34872198600186,0.237321436272564,FALSE +"HCC827","Pearson.est","potassium channel blocker",-0.37411,-1.01,0.413,1132,0.796,"oleoylethanolamide, ML133",0.384049948343599,0.0990869322623309,FALSE +"HCC827","Pearson.est","PPAR receptor agonist",-0.3649,-1,0.433,1132,0.778,"oleoylethanolamide, ciprofibrate, pterostilbene",0.363512103646635,0.109020403010311,FALSE +"HCC827","Pearson.est","progesterone receptor agonist",0.286,0.755,0.736,51,1,"nomegestrol.acetate",0.133122185662501,0,FALSE +"HCC827","Pearson.est","proteasome inhibitor",0.22296,0.587,0.938,464,1,"MG.132, oprozomib, ixazomib, ixazomib.citrate",0.0277971616209356,0,FALSE +"HCC827","Pearson.est","protein synthesis inhibitor",0.2157,0.561,0.952,227,1,"chloramphenicol.palmitate, anguidine, azomycin..2.nitroimidazole., clindamycin.phosphate",0.0213630516155257,0,FALSE +"HCC827","Pearson.est","protein tyrosine kinase inhibitor",-0.38498,-1.03,0.413,1212,0.841,"BMS.599626, NVP.TAE226, AV.412, CP.724714",0.384049948343599,0.0752040042020878,FALSE +"HCC827","Pearson.est","RAF inhibitor",0.46693,1.29,0.169,502,0.655,"SB.590885, vemurafenib, CEP.32496, regorafenib, AZ.628, dabrafenib, GDC.0879, sorafenib",0.772113295386326,0.183758700008217,FALSE +"HCC827","Pearson.est","RET tyrosine kinase inhibitor",0.3353,0.909,0.555,312,0.997,"vandetanib, regorafenib, sunitinib",0.255707016877324,0.00130484168834428,FALSE +"HCC827","Pearson.est","retinoid receptor agonist",0.74749,1.98,0.00542,219,0.219,"AM.580, adapalene, fenretinide, LE.135",2.26600071346161,0.659555885159882,TRUE +"HCC827","Pearson.est","ribonucleotide reductase inhibitor",-0.309,-0.823,0.67,1078,0.889,"triapine, gemcitabine, fludarabine",0.173925197299174,0.0510982390297863,FALSE +"HCC827","Pearson.est","serotonin receptor antagonist",0.29447,0.804,0.679,441,1,"lurasidone, pirenperone, lerisetron, SB.200646, sertindole",0.168130225719498,0,FALSE +"HCC827","Pearson.est","sodium channel blocker",0.53513,1.42,0.12,310,0.708,"oxcarbazepine, benzocaine, cibenzoline, butamben, ajmaline, brivaracetam",0.920818753952375,0.149966742310231,FALSE +"HCC827","Pearson.est","src inhibitor",-0.60044,-1.61,0.0614,1308,0.567,"PP.1, ZM.306416, TG.100572, PP.2",1.21183162885883,0.246416941107093,FALSE +"HCC827","Pearson.est","sterol demethylase inhibitor",0.70066,1.84,0.0192,296,0.205,"ketoconazole, terconazole, posaconazole, sulconazole",1.71669877129645,0.688246138944246,TRUE +"HCC827","Pearson.est","TGF beta receptor inhibitor",0.60056,1.6,0.0425,230,0.464,"D.4476, adaprev, SB.431542",1.37161106994969,0.333482019445119,FALSE +"HCC827","Pearson.est","thymidylate synthase inhibitor",-0.43119,-1.17,0.26,941,0.783,"raltitrexed, trifluridine, ftorafur, doxifluridine",0.585026652029182,0.106238237942057,FALSE +"HCC827","Pearson.est","topoisomerase inhibitor",0.203,0.539,0.967,523,1,"etoposide.phosphate, beta.lapachone, dexrazoxane, amsacrine, TAS.103, epirubicin, mitoxantrone, nemorubicin, amonafide, topotecan",0.0145735259169983,0,FALSE +"HCC827","Pearson.est","tubulin polymerization inhibitor",0.40194,1.06,0.371,484,0.98,"taltobulin, flubendazole, dolastatin.10, nocodazole, KX2.391, combretastatin.A.4, CYT.997, oxibendazole, indibulin, vinblastine, epothilone.d, verubulin, vindesine",0.430626090384954,0.00877392430750515,FALSE +"HCC827","Pearson.est","tyrosine kinase inhibitor",-0.23421,-0.654,0.871,1285,0.997,"NVP.TAE226, AMG.208, AV.412, cabozantinib, CP.724714",0.0599818449923368,0.00130484168834428,FALSE +"HCC827","Pearson.est","VEGFR inhibitor",-0.34386,-0.94,0.502,1083,0.79,"nintedanib, PD.173074, vatalanib, KI.8751, golvatinib, orantinib, MK.2461, foretinib, ZM.306416, cabozantinib, BMS.690514, TG.100572, XL.647",0.299296282854981,0.102372908709559,FALSE +"HCC827","Pearson.est","vitamin D receptor agonist",-0.51255,-1.38,0.143,1228,0.669,"tacalcitol, calcitriol, ercalcitriol",0.844663962534938,0.174573882232177,FALSE +"HCC95","Pearson.est","EGFR inhibitor",-0.57702,-1.51,0.0847,1076,0.28,"AST.1306, afatinib, tyrphostin.AG.494, poziotinib, erlotinib, canertinib, osimertinib, tyrphostin.AG.1478, vandetanib, rociletinib, tucatinib, BMS.690514, neratinib, dovitinib, TAK.285, WZ8040, WZ.4002, WZ.3146, AEE788, ARRY.334543, lapatinib, XL.647, GW.583340, gefitinib, CP.724714, dacomitinib, AZD8931, pelitinib",1.07211658966929,0.552841968657781,FALSE +"HCC95","Pearson.est","Abl kinase inhibitor",-0.41747,-1.11,0.335,966,0.529,"tozasertib, GZD824, metatinib, ponatinib, imatinib, bosutinib, dasatinib",0.474955192963155,0.276544327964814,FALSE +"HCC95","Pearson.est","acetylcholine receptor agonist",-0.39232,-1.04,0.399,1164,0.605,"oxiracetam, xanomeline",0.399027104313252,0.218244625347531,FALSE +"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.37871,-0.996,0.447,989,0.576,"diphemanil, iododexetimide, hyoscyamine",0.349692476868064,0.239577516576788,FALSE +"HCC95","Pearson.est","adenosine receptor antagonist",-0.39178,-1.03,0.408,843,0.586,"PSB.1115, theophylline, SCH.58261, CGS.15943",0.38933983691012,0.232102383981909,FALSE +"HCC95","Pearson.est","adrenergic receptor agonist",0.23639,0.696,0.824,422,0.945,"metaraminol, methyldopa, isoetharine, oxymetazoline, xylazine, ritodrine",0.0840727883028842,0.0245681914907371,FALSE +"HCC95","Pearson.est","adrenergic receptor antagonist",-0.22449,-0.602,0.93,1092,0.915,"atenolol...., metoprolol, prazosin, RS.17053, practolol",0.0315170514460649,0.0385789059335517,FALSE +"HCC95","Pearson.est","AKT inhibitor",-0.47178,-1.22,0.256,1159,0.484,"CCT128930, triciribine, AZD5363, GDC.0068, GSK2110183, uprosertib",0.59176003468815,0.315154638355588,FALSE +"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.60228,-1.61,0.0538,886,0.26,"brigatinib, AZD3463, DMH1, crizotinib, alectinib, SB.505124, AP26113, NVP.TAE684, CEP.37440, GW.788388",1.26921772433361,0.585026652029182,FALSE +"HCC95","Pearson.est","androgen receptor antagonist",0.5284,1.51,0.0829,508,0.275,"enzalutamide, RU.58841, bicalutamide",1.08144546944973,0.560667306169737,FALSE +"HCC95","Pearson.est","antioxidant",0.61925,1.78,0.0396,421,0.146,"mesna, benfotiamine, trolox, chlorogenic.acid",1.40230481407449,0.835647144215563,TRUE +"HCC95","Pearson.est","AP inhibitor",0.65109,1.88,0.0242,157,0.106,"tanshinone.i, LCL.161, birinapant, GDC.0152",1.61618463401957,0.97469413473523,TRUE +"HCC95","Pearson.est","ATPase inhibitor",0.42317,1.22,0.216,191,0.576,"oligomycin.a, thonzonium, omeprazole, blebbistatin...., k.strophanthidin",0.665546248849069,0.239577516576788,FALSE +"HCC95","Pearson.est","Aurora kinase inhibitor",-0.49804,-1.31,0.176,906,0.388,"PHA.680632, CCT129202, barasertib.HQPA, MK.8745, GSK1070916, tozasertib, AT.9283, MK.5108, AMG900, alisertib, aurora.a.inhibitor.i, PF.03814735, TAK.901, barasertib, danusertib, CCT137690",0.75448733218585,0.411168274405793,FALSE +"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.29052,0.826,0.65,433,0.873,"tilmicosin, josamycin, valnemulin, tedizolid",0.187086643357144,0.0589857562944303,FALSE +"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.60345,1.64,0.0803,363,0.217,"finafloxacin, novobiocin, sarafloxacin, sparfloxacin, norfloxacin",1.09528445472132,0.66354026615147,FALSE +"HCC95","Pearson.est","BCL inhibitor",-0.46096,-1.22,0.237,1001,0.484,"HA14.1, ABT.737, obatoclax, navitoclax",0.625251653989896,0.315154638355588,FALSE +"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.52128,-1.39,0.155,966,0.386,"tozasertib, GZD824, metatinib, ponatinib, imatinib, bosutinib, dasatinib",0.809668301829709,0.413412695328245,FALSE +"HCC95","Pearson.est","benzodiazepine receptor agonist",0.3704,1.04,0.393,95,0.688,"lorazepam, temazepam, bentazepam",0.405607449624573,0.162411561764489,FALSE +"HCC95","Pearson.est","bromodomain inhibitor",-0.72227,-1.87,0.0172,1187,0.143,"JQ1...., PFI.1, I.BET.762, OTX015",1.76447155309245,0.844663962534938,TRUE +"HCC95","Pearson.est","calcium channel blocker",0.33097,0.938,0.49,243,0.81,"cinnarazine, SR.33805, fendiline, pranidipine",0.309803919971486,0.0915149811213502,FALSE +"HCC95","Pearson.est","CC chemokine receptor antagonist",0.359,1.05,0.357,373,0.71,"MK.0812, navarixin, PF.04136309",0.447331783887807,0.148741651280925,FALSE +"HCC95","Pearson.est","CDK inhibitor",-0.2923,-0.769,0.727,1248,0.815,"TG.02, PHA.848125, alvocidib, R547, abemaciclib",0.138465589140962,0.0888423912600234,FALSE +"HCC95","Pearson.est","CHK inhibitor",-0.65271,-1.73,0.0162,1056,0.189,"SCH.900776, PF.477736, LY2606368, CHIR.124, SB.218078",1.79048498545737,0.723538195826756,TRUE +"HCC95","Pearson.est","cyclooxygenase inhibitor",0.24102,0.694,0.805,110,0.914,"metoxibutropate, phenylbutazone, FR.122047",0.0942041196321315,0.0390538042661686,FALSE +"HCC95","Pearson.est","cytochrome P450 inhibitor",-0.54443,-1.45,0.109,962,0.342,"morin, PF.4981517, metyrapone",0.962573502059376,0.465973893943865,FALSE +"HCC95","Pearson.est","DNA alkylating agent",-0.33084,-0.887,0.576,1275,0.692,"cyclophosphamide, mitomycin.c, dacarbazine, TH.302",0.239577516576788,0.159893905543242,FALSE +"HCC95","Pearson.est","DNA inhibitor",-0.34654,-0.909,0.548,1100,0.675,"mechlorethamine, nithiamide, teroxirone, bendamustine, chlorambucil, valrubicin",0.261219441515631,0.170696227168975,FALSE +"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.57536,-1.53,0.0723,918,0.298,"disulfiram, fdcyd, SGI.1027, decitabine",1.14086170270547,0.525783735923745,FALSE +"HCC95","Pearson.est","DNA polymerase inhibitor",0.39585,1.11,0.297,310,0.734,"famciclovir, cidofovir, foscarnet, menadione",0.527243550682788,0.134303940083929,FALSE +"HCC95","Pearson.est","DNA synthesis inhibitor",-0.38423,-1.01,0.417,1293,0.57,"artemisinin, mitomycin.c, azodicarbonamide, artesunate",0.379863945026242,0.244125144327509,FALSE +"HCC95","Pearson.est","dopamine receptor antagonist",0.3804,1.08,0.329,330,0.695,"amisulpride, UH.232...., remoxipride, raclopride, nemonapride, thioproperazine, isofloxythepin, domperidone",0.482804102050026,0.158015195409886,FALSE +"HCC95","Pearson.est","estrogen receptor agonist",-0.27946,-0.723,0.79,950,0.823,"estradiol, PPT, estradiol.cypionate, levonorgestrel",0.102372908709559,0.0846001647877302,FALSE +"HCC95","Pearson.est","estrogen receptor antagonist",0.68694,1.95,0.0114,11,0.146,"toremifene, fulvestrant",1.94309514866353,0.835647144215563,TRUE +"HCC95","Pearson.est","FGFR inhibitor",-0.52185,-1.39,0.125,1178,0.386,"erdafitinib, dovitinib, lenvatinib, nintedanib",0.903089986991944,0.413412695328245,FALSE +"HCC95","Pearson.est","FLT3 inhibitor",-0.45307,-1.18,0.25,1248,0.491,"TG.02, midostaurin, dovitinib, pacritinib, TG.101348, lestaurtinib",0.602059991327962,0.308918507877032,FALSE +"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.49086,-1.31,0.197,881,0.388,"prednisolone.acetate, halobetasol.propionate, difluprednate, halcinonide, prednisolone.hemisuccinate, ciclesonide, fluocinolone.acetonide, fluticasone.propionate, flumethasone, desonide, methylprednisolone, deflazacort, triamcinolone.acetonide, beclomethasone.dipropionate, triamcinolone, betamethasone, fluorometholone",0.705533773838407,0.411168274405793,FALSE +"HCC95","Pearson.est","glutamate receptor antagonist",0.31395,0.908,0.557,992,0.793,"latrepirdine, IEM1754, ACDPP, SIB.1757, tiletamine, JNJ.16259685, CPP, felbamate, diazooxonorleucine, LY456236, MTPG, kynurenic.acid, CGP.37849",0.254144804826271,0.100726812682396,FALSE +"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.27911,0.804,0.679,150,0.809,"kenpaullone, LY2090314, GSK.3.inhibitor.IX",0.168130225719498,0.0920514783877277,FALSE +"HCC95","Pearson.est","growth factor receptor inhibitor",-0.65709,-1.74,0.0237,1325,0.214,"PHA.848125, GSK1838705A, danusertib, lestaurtinib",1.6252516539899,0.669586226650809,TRUE +"HCC95","Pearson.est","HCV inhibitor",0.31836,0.917,0.508,158,0.813,"narlaprevir, PSI.7976",0.294136287716081,0.0899094544059319,FALSE +"HCC95","Pearson.est","HDAC inhibitor",-0.278,-0.724,0.774,1039,0.84,"chidamide, panobinostat, ACY.1215, scriptaid, pyroxamide, belinostat, RGFP966, NSC.3852, resminostat, vorinostat",0.111259039317107,0.0757207139381184,FALSE +"HCC95","Pearson.est","histamine receptor antagonist",0.54948,1.61,0.072,271,0.218,"nizatidine, astemizole, famotidine, ICI.162846, tecastemizole, BF2.649, zolantidine, tiotidine, epinastine",1.14266750356873,0.661543506395395,FALSE +"HCC95","Pearson.est","HMGCR inhibitor",0.76538,2.22,0,162,0.0702,"atorvastatin, pitavastatin, fluvastatin, lovastatin",Inf,1.15366288787019,TRUE +"HCC95","Pearson.est","HSP inhibitor",-0.64617,-1.71,0.0267,986,0.185,"alvespimycin, NMS.E973, XL888, VER.49009, NVP.AUY922, ganetespib, SNX.5422, tanespimycin, SNX.2112, BIIB021, PU.H71",1.57348873863542,0.732828271596986,TRUE +"HCC95","Pearson.est","JAK inhibitor",-0.50259,-1.34,0.155,966,0.38,"tozasertib, ruxolitinib, PRT062070, baricitinib, AT.9283, LY2784544, AZ960, TG.02, pacritinib, TG.101348, lestaurtinib",0.809668301829709,0.42021640338319,FALSE +"HCC95","Pearson.est","KIT inhibitor",-0.39138,-1.01,0.44,1094,0.57,"imatinib, masitinib, dasatinib, midostaurin, motesanib, lenvatinib",0.356547323513813,0.244125144327509,FALSE +"HCC95","Pearson.est","MDM inhibitor",0.67816,1.91,0.0207,288,0.108,"idasanutlin, RITA, nutlin.3",1.68402965454308,0.96657624451305,TRUE +"HCC95","Pearson.est","MEK inhibitor",0.68571,1.99,0.0154,333,0.17,"selumetinib, refametinib, TAK.733, MEK162, AZD8330, Ro.4987655, PD.184352, U.0126, cobimetinib, PD.98059, PD.318088, PD.0325901, trametinib, AS.703026, PD.198306",1.81247927916354,0.769551078621726,TRUE +"HCC95","Pearson.est","MET inhibitor",-0.3439,-0.922,0.555,965,0.671,"NVP.BVU972, PF.04217903, LY2801653",0.255707016877324,0.173277479831008,FALSE +"HCC95","Pearson.est","microtubule inhibitor",-0.57764,-1.52,0.081,1035,0.288,"vinblastine, podophyllotoxin, cabazitaxel, cytochalasin.b, triclabendazole, colchicine, vinflunine, D.64131",1.09151498112135,0.540607512240769,FALSE +"HCC95","Pearson.est","mTOR inhibitor",-0.5199,-1.38,0.129,1020,0.359,"SB.2343, voxtalisib, temsirolimus, AZD2014, WAY.600, PF.04691502, NVP.BEZ235, MLN0128, sirolimus, AZD8055, OSI.027, GSK2126458, LY3023414, PF.05212384, WYE.125132, GDC.0980, everolimus",0.889410289700751,0.444905551421681,FALSE +"HCC95","Pearson.est","NFkB pathway inhibitor",0.34137,0.989,0.448,107,0.743,"tyloxapol, parthenolide, BAY.11.7085",0.348721986001856,0.129011186239425,FALSE +"HCC95","Pearson.est","opioid receptor agonist",-0.31193,-0.814,0.672,1217,0.768,"salvinorin.a, spiradoline",0.172630726946175,0.114638779968488,FALSE +"HCC95","Pearson.est","p38 MAPK inhibitor",-0.42806,-1.12,0.315,1108,0.53,"SB.239063, skepinone.l, talmapimod",0.501689446210399,0.275724130399211,FALSE +"HCC95","Pearson.est","PARP inhibitor",-0.59112,-1.55,0.0613,1006,0.322,"niraparib, PJ.34, endo.IWR.1, olaparib, talazoparib",1.21253952548158,0.492144128304169,FALSE +"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.38676,-1.01,0.426,1072,0.57,"ponatinib, imatinib, masitinib, crenolanib, dasatinib, motesanib, dovitinib, lenvatinib, linifanib, nintedanib",0.370590400897281,0.244125144327509,FALSE +"HCC95","Pearson.est","phosphatase inhibitor",0.17656,0.498,0.982,395,0.983,"BVT.948, AS.1949490, menadione, alexidine",0.00788851221305034,0.00744648216786438,FALSE +"HCC95","Pearson.est","phosphodiesterase inhibitor",0.28878,0.835,0.639,367,0.895,"EMD.53998, enoximone, trequinsin, GSK256066",0.1944991418416,0.048176964684088,FALSE +"HCC95","Pearson.est","PI3K inhibitor",-0.50704,-1.35,0.16,988,0.384,"idelalisib, SB.2343, voxtalisib, taselisib, GDC.0941, buparlisib, CUDC.907, PF.04691502, YM.201636, NVP.BEZ235, TG.100713, GSK2126458, LY3023414, PF.05212384, GDC.0980, CH5132799, PI3K.IN.2",0.795880017344075,0.415668775632469,FALSE +"HCC95","Pearson.est","PLK inhibitor",-0.77682,-2.03,0.00317,1235,0.0984,"HMN.214, NMS.1286937, GSK461364, GW.843682X, volasertib, BI.2536",2.49894073778225,1.00700490156866,TRUE +"HCC95","Pearson.est","potassium channel blocker",-0.26737,-0.702,0.806,1032,0.832,"mepivacaine, ibutilide, ML133",0.0936649581949093,0.0798766737092761,FALSE +"HCC95","Pearson.est","PPAR receptor agonist",0.37444,1.09,0.313,125,0.724,"clofibrate, GW.501516",0.504455662453552,0.140261433802853,FALSE +"HCC95","Pearson.est","progesterone receptor agonist",0.1884,0.541,0.957,318,0.997,"nomegestrol.acetate, norgestrel, norethindrone.acetate",0.0190880622231565,0.00130484168834428,FALSE +"HCC95","Pearson.est","proteasome inhibitor",0.28188,0.817,0.665,39,0.854,"oprozomib",0.177178354696895,0.068542129310995,FALSE +"HCC95","Pearson.est","protein synthesis inhibitor",-0.43855,-1.15,0.29,1000,0.5,"tedizolid.phosphate, bruceantin, mercaptopurine, puromycin, anguidine, harringtonine, emetine, chloramphenicol.palmitate",0.537602002101044,0.301029995663981,FALSE +"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.44536,-1.18,0.283,1391,0.491,"PP.121, CP.724714",0.54821356447571,0.308918507877032,FALSE +"HCC95","Pearson.est","RAF inhibitor",0.67295,1.93,0.0163,254,0.12,"dabrafenib, AZ.628, vemurafenib, CEP.32496, LGX818, SB.590885, PLX.4720",1.78781239559604,0.920818753952375,TRUE +"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.5291,-1.38,0.137,1199,0.359,"vandetanib, cabozantinib",0.863279432843593,0.444905551421681,FALSE +"HCC95","Pearson.est","retinoid receptor agonist",-0.28491,-0.747,0.749,1053,0.827,"bexarotene, CD.437, tamibarotene",0.125518182300534,0.0824944904474534,FALSE +"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.22867,0.645,0.898,1113,0.941,"pentostatin, gemcitabine, fludarabine, cladribine, hydroxyurea, triapine, clofarabine, cytarabine, fludarabine.phosphate, LY2334737",0.0467236633326956,0.0264103765727431,FALSE +"HCC95","Pearson.est","serotonin receptor antagonist",-0.31604,-0.827,0.665,1417,0.767,"pirenperone",0.177178354696895,0.115204636051019,FALSE +"HCC95","Pearson.est","sodium channel blocker",0.41229,1.22,0.226,248,0.576,"A.803467, cibenzoline, benzethonium, ajmaline, quinidine",0.645891560852599,0.239577516576788,FALSE +"HCC95","Pearson.est","src inhibitor",-0.7274,-1.92,0.00626,1077,0.139,"PP.2, masitinib, KX2.391, bosutinib, dasatinib, saracatinib, TG.100572",2.20342566678957,0.856985199745905,TRUE +"HCC95","Pearson.est","sterol demethylase inhibitor",-0.61546,-1.64,0.0416,1055,0.247,"sulconazole, terconazole, lanoconazole",1.38090666937326,0.607303046740334,TRUE +"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.43649,-1.15,0.288,821,0.5,"SB.525334, repsox, SB.431542, LY2109761, adaprev",0.540607512240769,0.301029995663981,FALSE +"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.40538,-1.07,0.371,876,0.575,"capecitabine, doxifluridine, carmofur, raltitrexed",0.430626090384954,0.24033215531037,FALSE +"HCC95","Pearson.est","topoisomerase inhibitor",-0.57304,-1.53,0.0773,1162,0.298,"topotecan, SN.38, irinotecan, exatecan.mesylate, etoposide, daunorubicin, licochalcone.a, genz.644282, camptothecin, fleroxacin, teniposide, mitoxantrone, TAS.103, amsacrine, valrubicin",1.11182050608168,0.525783735923745,FALSE +"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.68665,-1.79,0.0143,1035,0.19,"vinblastine, albendazole, vindesine, CYT.997, fosbretabulin, podophyllotoxin, KX2.391, dolastatin.10, mebendazole, verubulin, BNC105, indibulin, nocodazole, flubendazole, oxibendazole, plinabulin, parbendazole, fenbendazole, taltobulin, paclitaxel, ABT.751, epothilone.b, vinorelbine, docetaxel",1.84466396253494,0.721246399047171,TRUE +"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.38891,-1.03,0.42,1157,0.586,"tyrphostin.AG.99, vandetanib, tivantinib, cabozantinib, dasatinib, UNC2250, PP.121, CP.724714",0.3767507096021,0.232102383981909,FALSE +"HCC95","Pearson.est","VEGFR inhibitor",-0.46184,-1.21,0.228,1199,0.48,"vandetanib, cabozantinib, motesanib, BMS.690514, dovitinib, lenvatinib, foretinib, AEE788, TG.100572, XL.647, linifanib, nintedanib",0.642065152999546,0.318758762624413,FALSE +"HCC95","Pearson.est","vitamin D receptor agonist",0.27785,0.809,0.702,334,0.833,"ercalcitriol, maxacalcitol, alfacalcidol",0.153662887870195,0.0793549985932124,FALSE +"H1650","Pearson.est","EGFR inhibitor",-0.3432,-0.982,0.444,1165,0.594,"AZD8931, canertinib, ARRY.334543, CP.724714, pelitinib, WZ8040, dovitinib, dacomitinib, AST.1306, PD.168393, BIBU.1361, poziotinib, osimertinib, FERb.033, BMS.690514, afatinib, icotinib, erlotinib, vandetanib",0.35261702988538,0.226213555018806,FALSE +"H1650","Pearson.est","Abl kinase inhibitor",0.52231,1.31,0.178,347,1,"bosutinib, flumatinib, KW.2449, nilotinib, metatinib, imatinib",0.749579997691106,0,FALSE +"H1650","Pearson.est","acetylcholine receptor agonist",0.32694,0.817,0.697,432,0.973,"tremorine, nicotine",0.156767221901991,0.0118871597316481,FALSE +"H1650","Pearson.est","acetylcholine receptor antagonist",0.30986,0.783,0.736,129,0.916,"dicycloverine",0.133122185662501,0.0381045263321496,FALSE +"H1650","Pearson.est","adenosine receptor antagonist",0.42246,1.05,0.384,259,0.877,"sulmazole, PSB.1115",0.415668775632469,0.0570004066339595,FALSE +"H1650","Pearson.est","adrenergic receptor agonist",-0.25532,-0.712,0.812,1145,0.957,"A61603, buphenine, isoetharine, epinephrine, isoxsuprine, terbutaline",0.0904439707588247,0.0190880622231565,FALSE +"H1650","Pearson.est","adrenergic receptor antagonist",0.46659,1.18,0.286,497,0.921,"dronedarone, naftidrofuryl, dihydroergocristine, imiloxan, metoprolol, carvedilol, propranolol, oxprenolol, idazoxan, practolol",0.543633966870957,0.0357403698031511,FALSE +"H1650","Pearson.est","AKT inhibitor",-0.21523,-0.619,0.932,308,0.953,"AT7867, palomid.529, ONC201, CCT128930, uprosertib, AZD5363, triciribine, A.674563, MK.2206, GSK2110183, GDC.0068",0.0305840876460186,0.0209070993616736,FALSE +"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.35893,0.904,0.564,333,0.992,"DMH1, AZD3463, crizotinib, brigatinib",0.248720896016658,0.00348832784582135,FALSE +"H1650","Pearson.est","androgen receptor antagonist",0.30195,0.762,0.78,491,0.907,"nilutamide, flutamide, enzalutamide",0.10790539730952,0.0423927129399047,FALSE +"H1650","Pearson.est","antioxidant",0.4993,1.27,0.203,725,0.97,"chlorogenic.acid, trolox, taurine, rutin, benfotiamine, mesna",0.692503962086787,0.0132282657337552,FALSE +"H1650","Pearson.est","AP inhibitor",-0.49486,-1.35,0.143,1146,0.433,"birinapant, LCL.161, GDC.0152",0.844663962534938,0.363512103646635,FALSE +"H1650","Pearson.est","ATPase inhibitor",0.51671,1.3,0.156,596,0.951,"digoxin, digitoxin, rabeprazole, k.strophanthidin, omeprazole, ouabain, oligomycin.a, digitoxigenin, NMS.873",0.806875401645538,0.0218194830625861,FALSE +"H1650","Pearson.est","Aurora kinase inhibitor",-0.25176,-0.718,0.813,1160,0.992,"CCT137690, GSK1070916, AT.9283, PF.03814735, TAK.901, hesperadin, barasertib, MLN.8054, ZM.447439",0.0899094544059319,0.00348832784582135,FALSE +"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.54236,1.35,0.121,540,1,"valnemulin, josamycin, tedizolid, dirithromycin, azithromycin",0.91721462968355,0,FALSE +"H1650","Pearson.est","bacterial DNA gyrase inhibitor",-0.21688,-0.617,0.915,311,0.919,"lomefloxacin, sparfloxacin, finafloxacin, novobiocin, norfloxacin, sarafloxacin, nadifloxacin, trovafloxacin",0.0385789059335517,0.0366844886138887,FALSE +"H1650","Pearson.est","BCL inhibitor",-0.39515,-1.14,0.295,1125,0.579,"HA14.1, navitoclax, ABT.737, venetoclax",0.530177984021837,0.237321436272564,FALSE +"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.6161,1.53,0.0567,535,1,"bosutinib, flumatinib, nilotinib, metatinib, imatinib, GZD824, dasatinib",1.24641694110709,0,FALSE +"H1650","Pearson.est","benzodiazepine receptor agonist",0.29469,0.73,0.802,189,0.933,"temazepam, indiplon, eprinomectin",0.0958256317158365,0.0301183562535,FALSE +"H1650","Pearson.est","bromodomain inhibitor",0.39851,0.993,0.463,499,0.948,"bromosporine, I.BET.762, I.BET151",0.334419008982047,0.0231916626619338,FALSE +"H1650","Pearson.est","calcium channel blocker",0.36196,0.906,0.564,173,1,"carboxyamidotriazole, SR.33805",0.248720896016658,0,FALSE +"H1650","Pearson.est","CC chemokine receptor antagonist",0.47565,1.18,0.25,196,0.921,"navarixin, SB.225002",0.602059991327962,0.0357403698031511,FALSE +"H1650","Pearson.est","CDK inhibitor",0.48975,1.23,0.219,455,0.882,"BMS.265246, BMS.387032, P276.00, dinaciclib, PHA.793887, JNJ.7706621, aminopurvalanol.a, kenpaullone, indirubin, TG.02, AT.7519, PHA.848125",0.659555885159882,0.0545314148681803,FALSE +"H1650","Pearson.est","CHK inhibitor",-0.84939,-2.4,0,1252,0.00698,"SCH.900776, PF.477736, CHIR.124, LY2606368, AZD7762, LY2603618",Inf,2.15614457737684,TRUE +"H1650","Pearson.est","cyclooxygenase inhibitor",0.34258,0.857,0.644,362,0.975,"tryptanthrin, FR.122047, sulfasalazine, piroxicam, indoprofen, suxibuzone, tepoxalin, ketoprofen",0.191114132640188,0.0109953843014632,FALSE +"H1650","Pearson.est","cytochrome P450 inhibitor",0.42646,1.07,0.404,4,0.942,"itraconazole",0.393618634889395,0.0259490972071227,FALSE +"H1650","Pearson.est","DNA alkylating agent",0.37778,0.937,0.535,232,1,"temozolomide, carboplatin, satraplatin, streptozotocin",0.271646217978772,0,FALSE +"H1650","Pearson.est","DNA inhibitor",0.26721,0.667,0.86,430,0.991,"carboplatin, sangivamycin, primaquine, pibenzimol, tirapazamine, carmustine, busulfan",0.0655015487564323,0.00392634551472468,FALSE +"H1650","Pearson.est","DNA methyltransferase inhibitor",-0.62533,-1.81,0.0351,1211,0.175,"azacitidine, decitabine, fdcyd",1.45469288353418,0.756961951313706,TRUE +"H1650","Pearson.est","DNA polymerase inhibitor",-0.49698,-1.42,0.104,1395,0.436,"adefovir.dipivoxil, trifluridine, cephalomannine",0.98296666070122,0.360513510731414,FALSE +"H1650","Pearson.est","DNA synthesis inhibitor",-0.52685,-1.56,0.0731,1342,0.316,"estramustine.phosphate, floxuridine, capecitabine, artesunate",1.13608262304214,0.500312917381596,FALSE +"H1650","Pearson.est","dopamine receptor antagonist",-0.42326,-1.2,0.246,1378,0.519,"piperacetazine, sertindole, clebopride, thioproperazine",0.609064892896621,0.284832642151542,FALSE +"H1650","Pearson.est","estrogen receptor agonist",-0.34519,-0.991,0.454,495,0.682,"equol, estradiol, estrone, erteberel, estradiol.cypionate, PPT, ethinyl.estradiol, levonorgestrel",0.342944147142896,0.166215625343521,FALSE +"H1650","Pearson.est","estrogen receptor antagonist",0.57476,1.44,0.0927,429,1,"danazol, raloxifene, tamoxifen, clomifene",1.0329202658555,0,FALSE +"H1650","Pearson.est","FGFR inhibitor",0.44233,1.11,0.332,503,1,"AZD4547, erdafitinib, regorafenib, lucitanib, PD.173074, nintedanib",0.478861916295964,0,FALSE +"H1650","Pearson.est","FLT3 inhibitor",0.45241,1.1,0.349,514,1,"ENMD.2076, GTP.14564, TG.101348, tyrphostin.AG.1296, KW.2449, tandutinib, TG.02, quizartinib, sorafenib",0.45717457304082,0,FALSE +"H1650","Pearson.est","glucocorticoid receptor agonist",-0.36822,-1.03,0.389,1237,0.692,"fluticasone.propionate, desonide, dexamethasone.acetate, prednisolone.hemisuccinate, triamcinolone.acetonide, prednisolone.acetate, fludroxycortide",0.410050398674292,0.159893905543242,FALSE +"H1650","Pearson.est","glutamate receptor antagonist",0.39998,1.01,0.454,636,0.942,"LY456236, tiletamine, diazooxonorleucine, CGP.37849, IEM1754, MTPG, CPP, ACDPP",0.342944147142896,0.0259490972071227,FALSE +"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.3526,0.878,0.615,365,0.99,"GSK.3.inhibitor.IX, tideglusib, kenpaullone, indirubin",0.211124884224583,0.00436480540245009,FALSE +"H1650","Pearson.est","growth factor receptor inhibitor",0.48537,1.23,0.227,455,0.882,"GSK1904529A, AZD3463, PHA.848125",0.643974142806877,0.0545314148681803,FALSE +"H1650","Pearson.est","HCV inhibitor",0.59355,1.48,0.0689,581,1,"PSI.7976, narlaprevir, daclatasvir, mericitabine, embelin",1.16178077809237,0,FALSE +"H1650","Pearson.est","HDAC inhibitor",0.26313,0.655,0.869,465,0.965,"M.344, AR.42, mocetinostat, givinostat, pyroxamide, entinostat, R306465, PCI.24781, RG2833, tacedinaline, SB.939",0.0609802235513335,0.0154726866562074,FALSE +"H1650","Pearson.est","histamine receptor antagonist",0.20931,0.524,0.979,332,1,"zolantidine, chloropyramine, lafutidine, tecastemizole",0.00921730819686218,0,FALSE +"H1650","Pearson.est","HMGCR inhibitor",-0.34935,-0.983,0.434,1164,0.623,"mevastatin, pitavastatin, simvastatin",0.362510270487489,0.20551195334083,FALSE +"H1650","Pearson.est","HSP inhibitor",-0.42066,-1.2,0.218,1098,0.519,"VER.49009, ganetespib, SNX.2112, BIIB021, tanespimycin, alvespimycin",0.661543506395395,0.284832642151542,FALSE +"H1650","Pearson.est","JAK inhibitor",0.41793,1.05,0.387,387,0.877,"filgotinib, CEP.33779, AZD1480, TG.101348, TG.101209, AZ960, TG.02, atiprimod",0.412289034981089,0.0570004066339595,FALSE +"H1650","Pearson.est","KIT inhibitor",0.30913,0.776,0.734,687,0.907,"cediranib, tandutinib, regorafenib, pazopanib, imatinib, masitinib, sorafenib, dasatinib, lenvatinib, KI.8751, telatinib",0.134303940083929,0.0423927129399047,FALSE +"H1650","Pearson.est","MDM inhibitor",-0.68225,-1.9,0.0146,1313,0.152,"RITA, serdemetan",1.83564714421556,0.818156412055227,TRUE +"H1650","Pearson.est","MEK inhibitor",-0.29227,-0.84,0.619,1106,0.82,"selumetinib, cobimetinib, Ro.4987655, trametinib, AZD8330, TAK.733, PD.318088, BIX.02188",0.208309350979882,0.0861861476162833,FALSE +"H1650","Pearson.est","MET inhibitor",-0.24164,-0.701,0.843,347,0.934,"PHA.665752, AMG458, PF.04217903, NVP.BVU972, LY2801653, INC.280",0.0741724253752577,0.0296531237699066,FALSE +"H1650","Pearson.est","microtubule inhibitor",0.35292,0.886,0.602,389,1,"D.64131, secnidazole, cabazitaxel",0.220403508742175,0,FALSE +"H1650","Pearson.est","mTOR inhibitor",0.45655,1.15,0.301,587,0.96,"ku.0063794, PP242, torin.1, PKI.179, WYE.354, AZD8055, AZD2014, GSK2126458, OSI.027, deforolimus, palomid.529, MLN0128, PF.04691502, GDC.0980, XL388, SB.2343, voxtalisib",0.521433504406157,0.0177287669604316,FALSE +"H1650","Pearson.est","NFkB pathway inhibitor",0.33573,0.85,0.661,323,0.962,"bindarit, EVP4593, Ro.106.9920, tyloxapol",0.17979854051436,0.0168249279621871,FALSE +"H1650","Pearson.est","opioid receptor agonist",0.56327,1.4,0.123,183,1,"trimebutine, cebranopadol",0.910094888560602,0,FALSE +"H1650","Pearson.est","p38 MAPK inhibitor",0.36882,0.92,0.571,267,1,"skepinone.l, talmapimod",0.243363891754152,0,FALSE +"H1650","Pearson.est","PARP inhibitor",0.49924,1.25,0.212,527,0.956,"niraparib, olaparib, PJ.34, endo.IWR.1, AG.14361",0.673664139071249,0.0195421077238999,FALSE +"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.31615,0.797,0.724,535,0.96,"trapidil, crenolanib, tandutinib, regorafenib, pazopanib, imatinib, masitinib, CP.673451, nintedanib, sorafenib, dasatinib",0.140261433802853,0.0177287669604316,FALSE +"H1650","Pearson.est","phosphatase inhibitor",0.31217,0.793,0.738,180,0.944,"menadione, AS.1949490, BVT.948",0.131943638176958,0.025028005701931,FALSE +"H1650","Pearson.est","phosphodiesterase inhibitor",-0.35764,-1.01,0.392,1350,0.685,"trequinsin, papaverine",0.406713932979543,0.164309428507574,FALSE +"H1650","Pearson.est","PI3K inhibitor",0.42417,1.06,0.391,785,0.926,"alpelisib, ZSTK.474, PKI.179, BGT226, GSK2126458, PI.828, pilaralisib, buparlisib, PF.04691502, GDC.0980, PI3K.IN.2, SB.2343, voxtalisib, taselisib, TG.100713, NVP.BEZ235, LY303511, CH5132799, GDC.0941, YM.201636, CUDC.907, PIK.75",0.407823242604133,0.0333890133180656,FALSE +"H1650","Pearson.est","PLK inhibitor",0.32229,0.802,0.697,680,0.975,"NMS.1286937, HMN.214, rigosertib",0.156767221901991,0.0109953843014632,FALSE +"H1650","Pearson.est","potassium channel blocker",-0.40111,-1.13,0.286,576,0.554,"dofetilide, mepivacaine, meglitinide, ML133, oleoylethanolamide, ibutilide",0.543633966870957,0.25649023527157,FALSE +"H1650","Pearson.est","PPAR receptor agonist",0.25157,0.638,0.905,1081,0.963,"GW.501516, clofibrate, pterostilbene, ciprofibrate, oleoylethanolamide, S26948, fenofibrate",0.0433514207947967,0.0163737128754655,FALSE +"H1650","Pearson.est","progesterone receptor agonist",0.36928,0.937,0.532,630,1,"danazol, melengestrol.acetate, dienogest, norethindrone, tanaproget",0.274088367704952,0,FALSE +"H1650","Pearson.est","proteasome inhibitor",-0.62273,-1.77,0.0253,1120,0.167,"oprozomib, bortezomib, ixazomib.citrate, ixazomib, delanzomib, ONX.0914",1.59687947882418,0.777283528852417,TRUE +"H1650","Pearson.est","protein synthesis inhibitor",0.43039,1.08,0.367,361,0.96,"cycloheximide, mercaptopurine, bruceantin, clofoctol, chloramphenicol.palmitate, brefeldin.a, florfenicol, homoharringtonine",0.435333935747911,0.0177287669604316,FALSE +"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.44253,1.09,0.368,367,0.98,"mubritinib, BMS.599626, rheochrysidin, tyrphostin.A9",0.434152181326482,0.00877392430750515,FALSE +"H1650","Pearson.est","RAF inhibitor",0.52797,1.32,0.149,664,1,"CEP.32496, TAK.632, SB.590885, regorafenib, PLX.4720, sorafenib, RAF265, AZ.628, vemurafenib",0.826813731587726,0,FALSE +"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.31061,0.783,0.745,514,0.916,"apatinib, regorafenib, sorafenib",0.127843727251707,0.0381045263321496,FALSE +"H1650","Pearson.est","retinoid receptor agonist",-0.82902,-2.41,0,1357,0.0105,"CD.437, adapalene, bexarotene, AM.580",Inf,1.97881070093006,TRUE +"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.25436,0.633,0.885,437,0.95,"fludarabine, hydroxyurea, cladribine, LY2334737",0.0530567293021746,0.0222763947111523,FALSE +"H1650","Pearson.est","serotonin receptor antagonist",0.26986,0.665,0.854,569,0.973,"SB.200646, lerisetron, lurasidone, RS.16566, SB.216641, SB.228357",0.068542129310995,0.0118871597316481,FALSE +"H1650","Pearson.est","sodium channel blocker",-0.22592,-0.644,0.896,1256,0.965,"ajmaline, brivaracetam, A.803467",0.0476919903378748,0.0154726866562074,FALSE +"H1650","Pearson.est","src inhibitor",0.34117,0.859,0.622,597,0.998,"bosutinib, PP.1, masitinib, saracatinib, dasatinib, KX2.391",0.206209615309181,0.000869458712628891,FALSE +"H1650","Pearson.est","sterol demethylase inhibitor",0.58547,1.45,0.0801,294,1,"lanoconazole, chlormidazole, posaconazole",1.09636748391576,0,FALSE +"H1650","Pearson.est","TGF beta receptor inhibitor",-0.51184,-1.41,0.122,735,0.395,"repsox, SB.431542, D.4476, adaprev, SB.525334, LY2109761",0.913640169325252,0.40340290437354,FALSE +"H1650","Pearson.est","thymidylate synthase inhibitor",-0.44373,-1.27,0.184,1425,0.505,"trifluridine, capecitabine",0.735182176990464,0.296708621881339,FALSE +"H1650","Pearson.est","topoisomerase inhibitor",-0.36338,-0.987,0.441,1318,0.65,"beta.lapachone, topotecan, irinotecan, rubitecan, camptothecin, exatecan.mesylate",0.355561410532161,0.187086643357144,FALSE +"H1650","Pearson.est","tubulin polymerization inhibitor",0.20292,0.511,0.966,658,0.993,"mebendazole, epothilone.d, oxibendazole, fenbendazole, CYT.997, combretastatin.A.4, ABT.751, KX2.391, vincristine, paclitaxel, plinabulin",0.0150228735845067,0.00305075150461883,FALSE +"H1650","Pearson.est","tyrosine kinase inhibitor",0.33369,0.842,0.659,367,0.952,"GTP.14564, mubritinib, BMS.599626, rheochrysidin, apatinib, regorafenib, aminopurvalanol.a, tivantinib, tyrphostin.A9",0.18111458540599,0.0213630516155257,FALSE +"H1650","Pearson.est","VEGFR inhibitor",0.18765,0.469,0.997,514,0.988,"cediranib, ENMD.2076, golvatinib, regorafenib, pazopanib, MGCD.265, SAR131675, lucitanib, PD.173074, tivozanib, nintedanib, sorafenib",0.00130484168834428,0.00524305541237188,FALSE +"H1650","Pearson.est","vitamin D receptor agonist",0.56069,1.42,0.106,306,1,"tacalcitol, alfacalcidol, ercalcitriol, maxacalcitol",0.97469413473523,0,FALSE +"H1975","Pearson.est","EGFR inhibitor",-0.65752,-1.96,0.0123,1061,0.179,"PD.153035, icotinib, vandetanib, CNX.2006, rociletinib, CP.724714, neratinib, afatinib, tucatinib, BIBX.1382, erlotinib, osimertinib, WZ.4002, lapatinib, dacomitinib, XL.647, BMS.690514, PD.168393, GW.583340, canertinib, AZD8931, WZ8040, poziotinib, WZ.3146, pelitinib, BIBU.1361",1.9100948885606,0.747146969020107,TRUE +"H1975","Pearson.est","Abl kinase inhibitor",-0.33708,-1,0.408,1302,0.649,"GZD824, dasatinib, bosutinib",0.38933983691012,0.187755303199631,FALSE +"H1975","Pearson.est","acetylcholine receptor agonist",0.43255,1.16,0.293,456,0.764,"pilocarpine, tremorine, nefiracetam, nicotine",0.533132379645891,0.11690664142431,FALSE +"H1975","Pearson.est","acetylcholine receptor antagonist",0.63138,1.69,0.0251,316,1,"dicycloverine, iododexetimide, methscopolamine",1.60032627851896,0,FALSE +"H1975","Pearson.est","adenosine receptor antagonist",0.48316,1.3,0.182,459,0.755,"SCH.58261, theophylline, PSB.1115, istradefylline, sulmazole",0.739928612014925,0.122053048370812,FALSE +"H1975","Pearson.est","adrenergic receptor agonist",0.24451,0.667,0.872,526,0.996,"isoetharine, clenbuterol, buphenine, terbutaline, epinephrine, A61603",0.0594835150674328,0.00174066157630127,FALSE +"H1975","Pearson.est","adrenergic receptor antagonist",0.27373,0.748,0.743,344,0.93,"carvedilol, idazoxan, pindolol, atipamezole, vincamine, oxprenolol",0.129011186239425,0.0315170514460649,FALSE +"H1975","Pearson.est","AKT inhibitor",-0.38873,-1.17,0.256,1158,0.517,"CCT128930, triciribine, GDC.0068, AT7867, MK.2206",0.59176003468815,0.286509456906058,FALSE +"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.51472,-1.54,0.0781,1221,0.241,"SB.505124, lorlatinib, AP26113, AZD3463, CEP.37440",1.1073489661227,0.617982957425132,FALSE +"H1975","Pearson.est","antioxidant",0.41654,1.13,0.326,659,0.753,"trolox, chlorogenic.acid, benfotiamine",0.486782399932061,0.123205023799299,FALSE +"H1975","Pearson.est","AP inhibitor",-0.60799,-1.81,0.0265,1156,0.168,"GDC.0152, tanshinone.i, idronoxil",1.57675412606319,0.774690718274137,TRUE +"H1975","Pearson.est","ATPase inhibitor",0.55161,1.48,0.0875,185,0.706,"ouabain, digitoxin, evodiamine, thonzonium, digitoxigenin",1.05799194697769,0.151195298948196,FALSE +"H1975","Pearson.est","Aurora kinase inhibitor",0.37194,1,0.434,178,0.724,"TAK.901, MK.5108, alisertib, tozasertib, barasertib, ZM.447439, AMG900",0.362510270487489,0.140261433802853,FALSE +"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.40004,1.08,0.36,212,0.726,"azalomycin.b, valnemulin",0.443697499232713,0.139063379299906,FALSE +"H1975","Pearson.est","bacterial DNA gyrase inhibitor",0.44353,1.2,0.254,238,0.713,"trovafloxacin, nadifloxacin, sarafloxacin, norfloxacin",0.595166283380062,0.146910470148134,FALSE +"H1975","Pearson.est","BCL inhibitor",-0.44562,-1.29,0.166,1228,0.415,"navitoclax, ABT.737, venetoclax",0.779891911959945,0.381951903287907,FALSE +"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.37221,-1.11,0.331,1302,0.573,"GZD824, dasatinib, bosutinib",0.480172006224281,0.24184537803261,FALSE +"H1975","Pearson.est","benzodiazepine receptor agonist",-0.24105,-0.743,0.758,1260,0.912,"bentazepam, CGS.20625",0.120330794367946,0.0400051616715838,FALSE +"H1975","Pearson.est","bromodomain inhibitor",0.33045,0.889,0.578,249,0.808,"I.BET151",0.238072161579471,0.0925886392254138,FALSE +"H1975","Pearson.est","calcium channel blocker",-0.32082,-0.952,0.488,436,0.696,"SKF.96365, tetrandrine, mibefradil, SR.33805, efonidipine.monoethanolate, carboxyamidotriazole, penfluridol",0.311580177997289,0.157390760389438,FALSE +"H1975","Pearson.est","CC chemokine receptor antagonist",0.56105,1.48,0.0866,397,0.706,"ZK811752, MK.0812, RS.504393, SB.225002",1.06248210798265,0.151195298948196,FALSE +"H1975","Pearson.est","CDK inhibitor",0.17686,0.483,0.982,413,1,"dinaciclib, PHA.793887, palbociclib, ribociclib, NU6027, abemaciclib, AT.7519",0.00788851221305034,0,FALSE +"H1975","Pearson.est","CHK inhibitor",0.28109,0.752,0.768,984,0.947,"LY2606368, SB.218078, PF.477736, AZD7762, SCH.900776, CHIR.124, LY2603618",0.114638779968488,0.0236500209967266,FALSE +"H1975","Pearson.est","cyclooxygenase inhibitor",-0.18748,-0.567,0.957,1171,0.989,"phenazone, tryptanthrin, phenylbutazone, ramifenazone",0.0190880622231565,0.0048037084028206,FALSE +"H1975","Pearson.est","cytochrome P450 inhibitor",0.406,1.09,0.354,462,0.804,"PF.4981517, cobicistat",0.450996737974212,0.0947439512515487,FALSE +"H1975","Pearson.est","DNA alkylating agent",0.14156,0.389,0.992,523,0.998,"estramustine, mitomycin.c, melphalan, cisplatin, satraplatin",0.00348832784582135,0.000869458712628891,FALSE +"H1975","Pearson.est","DNA inhibitor",-0.21428,-0.634,0.88,1163,0.971,"nithiamide, pibenzimol, chlorambucil, sangivamycin",0.0555173278498314,0.0127807700919951,FALSE +"H1975","Pearson.est","DNA polymerase inhibitor",0.36583,0.995,0.455,91,0.711,"menadione, cephalomannine",0.341988603342888,0.148130399270234,FALSE +"H1975","Pearson.est","DNA synthesis inhibitor",0.35272,0.939,0.522,507,0.79,"estramustine.phosphate, cyclocytidine, mitomycin.c, anisomycin, CB.10.277, capecitabine, artesunate, cisplatin",0.282329496997738,0.102372908709559,FALSE +"H1975","Pearson.est","dopamine receptor antagonist",0.24085,0.653,0.879,471,0.99,"paliperidone, nemonapride, UH.232...., domperidone, amisulpride, piperacetazine",0.0560111249262281,0.00436480540245009,FALSE +"H1975","Pearson.est","estrogen receptor agonist",-0.5283,-1.57,0.0559,1343,0.25,"equol, ethinyl.estradiol",1.25258819211358,0.602059991327962,FALSE +"H1975","Pearson.est","FGFR inhibitor",0.47288,1.27,0.203,375,0.629,"nintedanib, MK.2461, regorafenib, erdafitinib",0.692503962086787,0.201349354554731,FALSE +"H1975","Pearson.est","FLT3 inhibitor",0.20237,0.557,0.969,1093,1,"tozasertib, tandutinib, tyrphostin.AG.1296, TG.02, gilteritinib, sunitinib, ENMD.2076, ponatinib, lestaurtinib, sorafenib, dovitinib, quizartinib, GTP.14564, midostaurin, pacritinib, TG.101348, KW.2449",0.0136762229492347,0,FALSE +"H1975","Pearson.est","glucocorticoid receptor agonist",-0.53122,-1.57,0.0833,1088,0.25,"piretanide, ciclesonide, difluprednate, fluticasone.propionate, prednisolone.acetate, fluorometholone, clobetasol.propionate, dexamethasone.acetate, betamethasone, flumethasone.pivalate, triamcinolone.acetonide",1.07935499859321,0.602059991327962,FALSE +"H1975","Pearson.est","glutamate receptor antagonist",0.39527,1.04,0.417,509,0.779,"LY456236, MTPG, ACDPP, felbamate, IEM1754, diazooxonorleucine",0.379863945026242,0.108462542327436,FALSE +"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.28155,-0.846,0.634,1251,0.812,"LY2090314, TWS.119",0.197910742118267,0.0904439707588247,FALSE +"H1975","Pearson.est","growth factor receptor inhibitor",-0.70055,-2.07,0.00286,1195,0.205,"GSK1904529A, AZD3463, PHA.848125",2.54363396687096,0.688246138944246,TRUE +"H1975","Pearson.est","HDAC inhibitor",0.40054,1.08,0.352,551,0.726,"RGFP966, RG2833, M.344, belinostat, givinostat, trichostatin.a, panobinostat, R306465, ACY.1215, nexturastat.a, SB.939, dacinostat, pyroxamide, resminostat, scriptaid, vorinostat",0.453457336521869,0.139063379299906,FALSE +"H1975","Pearson.est","histamine receptor antagonist",0.50531,1.35,0.148,434,0.749,"astemizole, lafutidine, ICI.162846, epinastine, cimetidine, BF2.649, famotidine, nizatidine, tecastemizole",0.829738284605043,0.125518182300534,FALSE +"H1975","Pearson.est","HSP inhibitor",-0.26534,-0.764,0.73,359,0.92,"BIIB021, tanespimycin, NVP.AUY922, KW.2478, alvespimycin, guanidine, SNX.2112, XL888, ganetespib, SNX.5422, PU.H71, VER.49009, NMS.E973",0.136677139879544,0.0362121726544447,FALSE +"H1975","Pearson.est","JAK inhibitor",0.37757,1.01,0.438,599,0.754,"tozasertib, PRT062070, AZD1480, WHI.P154, AT.9283, TG.02, TG.101209, AZ960, baricitinib",0.3585258894959,0.122628654130226,FALSE +"H1975","Pearson.est","KIT inhibitor",0.34812,0.934,0.543,438,0.775,"masitinib, imatinib, tandutinib, regorafenib, telatinib, cediranib",0.265200170411153,0.11069829749369,FALSE +"H1975","Pearson.est","MDM inhibitor",0.43043,1.15,0.317,9,0.748,"serdemetan",0.498940737782249,0.126098402135539,FALSE +"H1975","Pearson.est","MEK inhibitor",-0.47669,-1.44,0.0984,1023,0.278,"MEK1.2.inhibitor, nobiletin, refametinib, AS.703026, cobimetinib, trametinib, TAK.733, PD.0325901, Ro.4987655, PD.318088, AZD8330",1.00700490156866,0.555955204081924,FALSE +"H1975","Pearson.est","MET inhibitor",0.55825,1.47,0.0913,506,0.634,"INC.280, NVP.BVU972, AMG458, LY2801653, PHA.665752",1.0395292224657,0.197910742118267,FALSE +"H1975","Pearson.est","microtubule inhibitor",0.62755,1.68,0.0375,156,0.467,"vinflunine, estramustine.phosphate, vinblastine, cabazitaxel, triclabendazole, D.64131",1.42596873227228,0.330683119433888,FALSE +"H1975","Pearson.est","mTOR inhibitor",-0.34562,-1.04,0.36,1085,0.617,"PKI.179, PP242, PI.103, everolimus, torin.1, OSI.027, torin.2, WYE.354, SB.2343, WAY.600, ku.0063794, XL388",0.443697499232713,0.209714835966758,FALSE +"H1975","Pearson.est","NFkB pathway inhibitor",-0.27897,-0.847,0.622,378,0.853,"betulinic.acid, IKK.2.inhibitor.V, BAY.11.7085, bindarit, Ro.106.9920, bortezomib, curcumin, EVP4593, BAY.11.7082, parthenolide...., parthenolide",0.206209615309181,0.069050968832477,FALSE +"H1975","Pearson.est","p38 MAPK inhibitor",-0.23915,-0.717,0.814,325,0.909,"talmapimod, TAK.715, CMPD.1, skepinone.l, SB.239063, VX.702, SB.242235",0.0893755951107988,0.0414361167780325,FALSE +"H1975","Pearson.est","PARP inhibitor",0.48618,1.29,0.214,356,0.67,"talazoparib, niraparib, endo.IWR.1, olaparib",0.669586226650809,0.173925197299174,FALSE +"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.40156,1.08,0.377,395,0.726,"linifanib, nintedanib, masitinib, imatinib, tandutinib, crenolanib, CP.673451, regorafenib, telatinib",0.423658649794207,0.139063379299906,FALSE +"H1975","Pearson.est","phosphatase inhibitor",0.27934,0.755,0.761,321,0.967,"menadione, mycophenolate.mofetil, AS.1949490",0.118615343229427,0.0145735259169983,FALSE +"H1975","Pearson.est","phosphodiesterase inhibitor",0.19034,0.505,0.975,428,1,"EMD.53998, YM.976, papaverine",0.0109953843014632,0,FALSE +"H1975","Pearson.est","PI3K inhibitor",0.19485,0.535,0.976,394,1,"PF.05212384, PF.04691502, GDC.0941, AZD6482, GDC.0980, NVP.BEZ235, CH5132799, PI.828, voxtalisib",0.0105501823333082,0,FALSE +"H1975","Pearson.est","PLK inhibitor",0.63793,1.68,0.037,481,0.467,"BI.2536, volasertib, rigosertib, GSK461364, HMN.214, GW.843682X",1.431798275933,0.330683119433888,FALSE +"H1975","Pearson.est","potassium channel blocker",0.3012,0.805,0.699,233,0.91,"meglitinide, oleoylethanolamide",0.155522824254319,0.0409586076789064,FALSE +"H1975","Pearson.est","PPAR receptor agonist",0.49317,1.29,0.175,233,0.67,"GW.501516, oleoylethanolamide",0.756961951313706,0.173925197299174,FALSE +"H1975","Pearson.est","progesterone receptor agonist",0.54412,1.46,0.0937,311,0.584,"norethindrone.acetate, melengestrol.acetate, dienogest, nomegestrol.acetate, danazol",1.02826040911222,0.233587152887601,FALSE +"H1975","Pearson.est","proteasome inhibitor",0.5076,1.36,0.124,467,0.797,"ONX.0914, carfilzomib, MG.132, oprozomib",0.906578314837765,0.0985416786038876,FALSE +"H1975","Pearson.est","protein synthesis inhibitor",0.4684,1.25,0.218,307,0.634,"chloramphenicol.palmitate, azomycin..2.nitroimidazole., homoharringtonine, puromycin, bruceantin, anguidine, harringtonine, emetine, cycloheximide",0.661543506395395,0.197910742118267,FALSE +"H1975","Pearson.est","protein tyrosine kinase inhibitor",-0.57903,-1.69,0.0439,1039,0.222,"rheochrysidin, mubritinib, CP.724714, AV.412",1.35753547975788,0.653647025549361,TRUE +"H1975","Pearson.est","RAF inhibitor",-0.35174,-1.04,0.368,1094,0.617,"CEP.32496, TAK.632, LGX818, RAF265, PLX.4720",0.434152181326482,0.209714835966758,FALSE +"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.37577,1.03,0.418,366,0.769,"apatinib, regorafenib",0.378823718224965,0.114073660198569,FALSE +"H1975","Pearson.est","retinoid receptor agonist",0.37817,1.01,0.435,150,0.754,"LE.135, fenretinide",0.361510743045363,0.122628654130226,FALSE +"H1975","Pearson.est","ribonucleotide reductase inhibitor",-0.48764,-1.47,0.0948,1110,0.275,"hydroxyurea, pentostatin, fludarabine.phosphate, cladribine, cytarabine",1.02319166266193,0.560667306169737,FALSE +"H1975","Pearson.est","serotonin receptor antagonist",0.36994,1,0.448,695,0.724,"paliperidone, SB.228357, pirenperone, tropisetron, RS.16566, lurasidone, lerisetron",0.348721986001856,0.140261433802853,FALSE +"H1975","Pearson.est","sodium channel blocker",0.3062,0.825,0.652,41,0.897,"benzocaine, butamben",0.18575240426808,0.0472075569559079,FALSE +"H1975","Pearson.est","src inhibitor",-0.40301,-1.2,0.243,1297,0.512,"saracatinib, dasatinib, bosutinib",0.614393726401688,0.290730039024169,FALSE +"H1975","Pearson.est","sterol demethylase inhibitor",-0.63509,-1.83,0.0123,1180,0.206,"posaconazole, lanoconazole, terconazole",1.9100948885606,0.686132779630847,TRUE +"H1975","Pearson.est","TGF beta receptor inhibitor",-0.18685,-0.539,0.967,1103,0.967,"LY2109761, repsox",0.0145735259169983,0.0145735259169983,FALSE +"H1975","Pearson.est","thymidylate synthase inhibitor",0.48492,1.3,0.191,457,0.755,"ftorafur, raltitrexed, doxifluridine, capecitabine",0.718966632752272,0.122053048370812,FALSE +"H1975","Pearson.est","topoisomerase inhibitor",0.47352,1.28,0.2,439,0.649,"nemorubicin, daunorubicin, exatecan.mesylate, amsacrine, etoposide, mitoxantrone, dexrazoxane, rubitecan, idarubicin, irinotecan, doxorubicin, valrubicin, topotecan, fleroxacin",0.698970004336019,0.187755303199631,FALSE +"H1975","Pearson.est","tubulin polymerization inhibitor",0.61565,1.65,0.0261,417,0.425,"flubendazole, combretastatin.A.4, taltobulin, vinblastine, paclitaxel, vindesine, verubulin, fosbretabulin, parbendazole, docetaxel, vincristine, albendazole, dolastatin.10, epothilone.b, mebendazole, BNC105, nocodazole, fenbendazole, plinabulin, oxibendazole, ABT.751, podophyllotoxin, KX2.391",1.58335949266172,0.371611069949688,FALSE +"H1975","Pearson.est","tyrosine kinase inhibitor",0.21118,0.56,0.945,261,1,"tivantinib, UNC2250, AMG.208, hypericin, apatinib",0.0245681914907371,0,FALSE +"H1975","Pearson.est","VEGFR inhibitor",0.26859,0.706,0.81,438,0.968,"SAR131675, golvatinib, linifanib, nintedanib, foretinib, TG.100572, MK.2461, regorafenib, telatinib, AEE788, tivozanib, cediranib",0.0915149811213502,0.0141246426916063,FALSE +"H1975","Pearson.est","vitamin D receptor agonist",0.33279,0.899,0.571,427,0.815,"alfacalcidol, tacalcitol, calcitriol",0.243363891754152,0.0888423912600234,FALSE +"H2009","Pearson.est","EGFR inhibitor",-0.48523,-1.3,0.181,1012,0.604,"afatinib, dacomitinib, BIBU.1361, poziotinib, AZD8931, PD.153035, neratinib, PD.168393, lapatinib, erlotinib, tyrphostin.AG.494, canertinib, pelitinib, ARRY.334543, OSI.420, osimertinib, tyrphostin.AG.1478, TAK.285, WZ.4002, gefitinib",0.742321425130815,0.218963061378868,FALSE +"H2009","Pearson.est","Abl kinase inhibitor",0.61654,1.83,0.0193,297,0.0998,"flumatinib, nilotinib, bafetinib, ponatinib, tozasertib, dasatinib, GZD824",1.71444269099223,1.00086945871263,TRUE +"H2009","Pearson.est","acetylcholine receptor agonist",-0.45869,-1.22,0.247,1045,0.686,"nefiracetam, tremorine, nicotine, pilocarpine",0.607303046740334,0.163675884293248,FALSE +"H2009","Pearson.est","acetylcholine receptor antagonist",-0.42446,-1.12,0.346,876,0.605,"hyoscyamine, darifenacin, methscopolamine, dicycloverine",0.460923901207223,0.218244625347531,FALSE +"H2009","Pearson.est","adenosine receptor antagonist",-0.56455,-1.53,0.0774,794,0.59,"PSB.1115, sulmazole, SCH.58261, MRS.1220, CGS.15943",1.11125903931711,0.229147988357856,FALSE +"H2009","Pearson.est","adrenergic receptor agonist",-0.32352,-0.866,0.59,826,0.709,"A61603, oxymetazoline, methyldopa, lidamidine, isoetharine, terbutaline, midodrine, metaraminol",0.229147988357856,0.149353764816933,FALSE +"H2009","Pearson.est","adrenergic receptor antagonist",-0.41966,-1.12,0.316,844,0.605,"vincamine, propranolol, pindolol, metoprolol, idazoxan, levobunolol, carvedilol, oxprenolol, prazosin, atenolol....",0.500312917381596,0.218244625347531,FALSE +"H2009","Pearson.est","AKT inhibitor",-0.36319,-0.972,0.481,913,0.688,"GDC.0068, GSK2110183, AZD5363, A.674563, uprosertib, CCT128930",0.317854923626168,0.162411561764489,FALSE +"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.27043,0.819,0.644,993,0.828,"brigatinib, DMH1, CEP.37440, GW.788388, alectinib, crizotinib, SB.505124, lorlatinib, AZD3463, AP26113, NVP.TAE684",0.191114132640188,0.0819696632151199,FALSE +"H2009","Pearson.est","antioxidant",-0.55937,-1.49,0.0804,783,0.398,"trolox, rutin, benfotiamine, taurine, chlorogenic.acid",1.09474395125155,0.400116927926312,FALSE +"H2009","Pearson.est","AP inhibitor",0.47646,1.4,0.117,143,0.253,"GDC.0152, birinapant, LCL.161",0.931814138253838,0.596879478824182,FALSE +"H2009","Pearson.est","ATPase inhibitor",0.34925,1.03,0.369,121,0.598,"ouabain, digoxin",0.43297363384094,0.223298816011589,FALSE +"H2009","Pearson.est","Aurora kinase inhibitor",0.57384,1.68,0.0344,257,0.159,"barasertib.HQPA, hesperadin, danusertib, PF.03814735, AMG900, AT.9283, barasertib, ENMD.2076, alisertib, SNS.314, tozasertib, CCT137690",1.46344155742847,0.798602875679548,TRUE +"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.32978,-0.878,0.601,1019,0.71,"josamycin, azithromycin, dirithromycin",0.22112552799726,0.148741651280925,FALSE +"H2009","Pearson.est","bacterial DNA gyrase inhibitor",-0.33905,-0.922,0.535,918,0.703,"trovafloxacin, sparfloxacin",0.271646217978772,0.153044674980176,FALSE +"H2009","Pearson.est","BCL inhibitor",0.34841,1.03,0.378,887,0.598,"gossypol, navitoclax, obatoclax, ABT.737, HA14.1, TW.37, oridonin, venetoclax",0.422508200162775,0.223298816011589,FALSE +"H2009","Pearson.est","Bcr.Abl kinase inhibitor",0.71573,2.09,0.0148,297,0.0988,"flumatinib, nilotinib, bafetinib, ponatinib, tozasertib, dasatinib, GZD824",1.82973828460504,1.00524305541237,TRUE +"H2009","Pearson.est","benzodiazepine receptor agonist",-0.42834,-1.15,0.3,1000,0.669,"piperazine, bentazepam, nefiracetam, gamma.aminobutyric.acid, indiplon, CL.218872, zaleplon",0.522878745280338,0.174573882232177,FALSE +"H2009","Pearson.est","bromodomain inhibitor",-0.55892,-1.5,0.0748,1061,0.486,"JQ1...., I.BET151, I.BET.762",1.12609840213554,0.313363730737707,FALSE +"H2009","Pearson.est","calcium channel blocker",0.24006,0.709,0.815,136,0.948,"SKF.96365, tetrandrine",0.0888423912600234,0.0231916626619338,FALSE +"H2009","Pearson.est","CC chemokine receptor antagonist",-0.41115,-1.12,0.321,846,0.605,"ZK811752, SB.225002, MK.0812, PF.04136309, navarixin",0.493494967595128,0.218244625347531,FALSE +"H2009","Pearson.est","CDK inhibitor",-0.45477,-1.21,0.245,899,0.663,"alvocidib, PHA.793887, AT.7519, BMS.387032, abemaciclib, JNJ.7706621, dinaciclib, indirubin, kenpaullone, BMS.265246, NU6027, P276.00, R547, arcyriaflavin.a",0.610833915635468,0.178486471595227,FALSE +"H2009","Pearson.est","CHK inhibitor",-0.29759,-0.799,0.712,1317,0.789,"SB.218078",0.147520006363144,0.10292299679058,FALSE +"H2009","Pearson.est","cyclooxygenase inhibitor",-0.36274,-0.99,0.451,1101,0.732,"ramifenazone, suxibuzone, pterostilbene, ketoprofen, FK.3311, aspirin, tryptanthrin",0.345823458122039,0.135488918941608,FALSE +"H2009","Pearson.est","cytochrome P450 inhibitor",0.33599,1.02,0.401,20,0.585,"metyrapone",0.396855627379818,0.23284413391782,FALSE +"H2009","Pearson.est","DNA alkylating agent",-0.4458,-1.2,0.251,1034,0.645,"carboplatin, cisplatin, melphalan, satraplatin, ifosfamide, cyclophosphamide",0.600326278518962,0.190440285364732,FALSE +"H2009","Pearson.est","DNA inhibitor",0.30131,0.894,0.534,77,0.748,"valrubicin, nimorazole, primaquine",0.272458742971444,0.126098402135539,FALSE +"H2009","Pearson.est","DNA methyltransferase inhibitor",0.41151,1.23,0.212,366,0.41,"SGI.1027, decitabine, azacitidine",0.673664139071249,0.387216143280265,FALSE +"H2009","Pearson.est","DNA polymerase inhibitor",-0.26973,-0.707,0.812,1171,0.828,"cephalomannine",0.0904439707588247,0.0819696632151199,FALSE +"H2009","Pearson.est","DNA synthesis inhibitor",-0.46491,-1.25,0.231,1094,0.666,"cisplatin, artemisinin, nelarabine, estramustine.phosphate, capecitabine, azodicarbonamide, CB.10.277",0.636388020107856,0.176525770829699,FALSE +"H2009","Pearson.est","dopamine receptor antagonist",-0.39661,-1.04,0.391,911,0.722,"mesoridazine, clebopride, isofloxythepin, acetophenazine, ziprasidone, lurasidone, sertindole",0.407823242604133,0.141462802430361,FALSE +"H2009","Pearson.est","estrogen receptor agonist",-0.37221,-1.03,0.426,1287,0.713,"estradiol, ethinyl.estradiol",0.370590400897281,0.146910470148134,FALSE +"H2009","Pearson.est","estrogen receptor antagonist",-0.53495,-1.45,0.0905,800,0.429,"toremifene, fulvestrant, clomifene, danazol",1.0433514207948,0.367542707815276,FALSE +"H2009","Pearson.est","FGFR inhibitor",0.71935,2.12,0.0174,213,0.13,"erdafitinib, MK.2461, PD.173074, regorafenib, lenvatinib, dovitinib, nintedanib",1.7594507517174,0.886056647693163,TRUE +"H2009","Pearson.est","FLT3 inhibitor",0.5079,1.51,0.0891,314,0.196,"sunitinib, tandutinib, ponatinib, ENMD.2076, midostaurin, dovitinib, tozasertib, sorafenib, GTP.14564, tyrphostin.AG.1296",1.05012229596313,0.707743928643524,FALSE +"H2009","Pearson.est","glucocorticoid receptor agonist",-0.54618,-1.49,0.0697,919,0.398,"fluocinolone.acetonide, flumethasone.pivalate, beclomethasone.dipropionate, flumethasone, ciclesonide, prednisolone.hemisuccinate, prednisolone, clobetasol.propionate, fluorometholone, methylprednisolone, desonide, deflazacort, fludroxycortide, halcinonide, triamcinolone",1.15676722190199,0.400116927926312,FALSE +"H2009","Pearson.est","glutamate receptor antagonist",-0.34517,-0.93,0.523,976,0.712,"kynurenic.acid, diazooxonorleucine, CPP, ACDPP, JNJ.16259685",0.281498311132726,0.147520006363144,FALSE +"H2009","Pearson.est","glycogen synthase kinase inhibitor",-0.27832,-0.752,0.748,984,0.834,"CHIR.99021, indirubin, kenpaullone",0.126098402135539,0.0788339493622613,FALSE +"H2009","Pearson.est","growth factor receptor inhibitor",0.22308,0.657,0.864,76,0.955,"danusertib",0.0634862575211067,0.0199966284162537,FALSE +"H2009","Pearson.est","HDAC inhibitor",-0.49665,-1.33,0.164,897,0.58,"nexturastat.a, trichostatin.a, tacedinaline, SB.939, RGFP966, AR.42, belinostat, panobinostat, ACY.1215, M.344, PCI.24781, resminostat, vorinostat, entinostat, givinostat, chidamide",0.785156151952302,0.236572006437063,FALSE +"H2009","Pearson.est","histamine receptor antagonist",-0.3637,-0.98,0.479,761,0.698,"lafutidine, tecastemizole, cimetidine, levocetirizine, ranitidine, cyproheptadine, tiotidine, terfenadine, pheniramine, nizatidine, famotidine, epinastine",0.319664486585437,0.156144577376839,FALSE +"H2009","Pearson.est","HSP inhibitor",0.19717,0.576,0.927,1092,1,"XL888, tanespimycin, NVP.AUY922, NMS.E973, ganetespib, SNX.2112, alvespimycin, VER.49009, PU.H71, guanidine, KW.2478, BIIB021, SNX.5422",0.0329202658555029,0,FALSE +"H2009","Pearson.est","JAK inhibitor",-0.15344,-0.417,0.991,908,0.995,"CEP.33779, TG.101209, LY2784544, WHI.P154, filgotinib",0.00392634551472468,0.00217691925427455,FALSE +"H2009","Pearson.est","KIT inhibitor",0.69843,2.03,0.0145,399,0.0816,"sunitinib, tandutinib, regorafenib, pazopanib, cediranib, lenvatinib, midostaurin, vatalanib, KI.8751, sorafenib, dasatinib, motesanib, OSI.930, masitinib, telatinib",1.83863199776503,1.08830984124614,TRUE +"H2009","Pearson.est","MEK inhibitor",0.1806,0.53,0.973,1115,0.969,"BIX.02188, PD.318088, MEK162, Ro.4987655, AS.703026, PD.184352, PD.0325901, selumetinib, cobimetinib, AZD8330, TAK.733, trametinib, arctigenin, MEK1.2.inhibitor, PD.198306, U.0126, nobiletin",0.0118871597316481,0.0136762229492347,FALSE +"H2009","Pearson.est","MET inhibitor",0.36926,1.09,0.348,116,0.584,"INC.280, NVP.BVU972",0.458420756053419,0.233587152887601,FALSE +"H2009","Pearson.est","microtubule inhibitor",0.51264,1.56,0.0636,246,0.175,"vinblastine, vinflunine, podophyllotoxin, D.64131, triclabendazole, colchicine",1.19654288435159,0.756961951313706,FALSE +"H2009","Pearson.est","mTOR inhibitor",-0.3408,-0.921,0.532,774,0.683,"palomid.529, LY3023414, torin.1, LY303511, ku.0063794, temsirolimus, PP242, WAY.600, GDC.0980, AZD2014, AZD8055, torin.2, MLN0128, PF.05212384, PF.04691502, OSI.027, XL388",0.274088367704952,0.165579296318467,FALSE +"H2009","Pearson.est","NFkB pathway inhibitor",-0.34351,-0.939,0.498,766,0.72,"curcumin, parthenolide, Ro.106.9920, EVP4593, BAY.11.7082, IKK.2.inhibitor.V, bindarit, parthenolide....",0.302770657240282,0.142667503568732,FALSE +"H2009","Pearson.est","opioid receptor agonist",-0.49318,-1.36,0.146,929,0.564,"trimebutine, ADL5859, cebranopadol, spiradoline",0.835647144215563,0.248720896016658,FALSE +"H2009","Pearson.est","p38 MAPK inhibitor",-0.57096,-1.56,0.0469,1187,0.853,"SB.239063, SB.242235, talmapimod, TAK.715",1.32882715728492,0.069050968832477,FALSE +"H2009","Pearson.est","PARP inhibitor",-0.57639,-1.54,0.0614,942,0.706,"E7449, talazoparib, endo.IWR.1, AZD2461, olaparib, niraparib",1.21183162885883,0.151195298948196,FALSE +"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.7051,2.05,0.0118,255,0.0929,"SU014813, sunitinib, CP.673451, crenolanib, tandutinib, linifanib, regorafenib, ponatinib, axitinib, pazopanib, lenvatinib, dovitinib, nintedanib, vatalanib, KI.8751, sorafenib, dasatinib",1.92811799269387,1.03198428600636,TRUE +"H2009","Pearson.est","phosphatase inhibitor",0.23371,0.68,0.817,158,0.957,"CID.5458317, BVT.948",0.0877779434675845,0.0190880622231565,FALSE +"H2009","Pearson.est","phosphodiesterase inhibitor",-0.36355,-0.987,0.446,915,0.711,"avanafil, cilostamide, YM.976, zardaverine, anagrelide",0.350665141287858,0.148130399270234,FALSE +"H2009","Pearson.est","PI3K inhibitor",0.18387,0.549,0.962,172,0.989,"buparlisib, idelalisib, SB.2343, ZSTK.474, GDC.0941",0.0168249279621871,0.0048037084028206,FALSE +"H2009","Pearson.est","PLK inhibitor",0.63352,1.84,0.0379,295,0.108,"BI.2536, rigosertib, HMN.214, volasertib",1.42136079003193,0.96657624451305,TRUE +"H2009","Pearson.est","potassium channel blocker",-0.56442,-1.51,0.0746,956,0.54,"dofetilide, meglitinide, mepivacaine",1.12726117252733,0.267606240177031,FALSE +"H2009","Pearson.est","progesterone receptor agonist",-0.42879,-1.14,0.282,954,0.654,"norethindrone.acetate, melengestrol.acetate, danazol, dienogest",0.549750891680639,0.184422251675733,FALSE +"H2009","Pearson.est","proteasome inhibitor",0.78033,2.34,0,185,0.0505,"bortezomib, ixazomib.citrate, carfilzomib, ixazomib, MG.132, delanzomib, oprozomib",Inf,1.29670862188134,TRUE +"H2009","Pearson.est","protein synthesis inhibitor",0.47859,1.43,0.106,171,0.242,"thiostrepton, anguidine, bruceantin, mercaptopurine, harringtonine, cycloheximide",0.97469413473523,0.616184634019569,FALSE +"H2009","Pearson.est","protein tyrosine kinase inhibitor",-0.32738,-0.884,0.595,1003,0.72,"tyrphostin.A9, rheochrysidin, PP.121",0.22548303427145,0.142667503568732,FALSE +"H2009","Pearson.est","RAF inhibitor",0.28104,0.861,0.64,979,0.78,"regorafenib, sorafenib, CEP.32496, TAK.632, AZ.628, PLX.4720, SB.590885, GDC.0879, dabrafenib, LGX818, vemurafenib, RAF265",0.193820026016113,0.10790539730952,FALSE +"H2009","Pearson.est","RET tyrosine kinase inhibitor",0.62312,1.86,0.0414,252,0.115,"cabozantinib, sunitinib, regorafenib, sorafenib",1.3829996588791,0.939302159646388,TRUE +"H2009","Pearson.est","retinoid receptor agonist",-0.26681,-0.72,0.804,872,0.833,"bexarotene, CD.437, AM.580",0.0947439512515487,0.0793549985932124,FALSE +"H2009","Pearson.est","ribonucleotide reductase inhibitor",0.27482,0.802,0.687,109,0.828,"LY2334737, cladribine",0.16304326294045,0.0819696632151199,FALSE +"H2009","Pearson.est","serotonin receptor antagonist",-0.59051,-1.59,0.0442,1038,1,"SB.228357, lerisetron, ziprasidone, pirenperone, lurasidone, sertindole, tropisetron",1.35457773065091,0,FALSE +"H2009","Pearson.est","sodium channel blocker",-0.3746,-1.01,0.42,916,0.723,"A.803467, triamterene, mexiletine, lappaconite, butamben, mepivacaine",0.3767507096021,0.140861702705469,FALSE +"H2009","Pearson.est","src inhibitor",0.34199,1,0.425,896,0.594,"KX2.391, dasatinib, PP.2, masitinib, PP.1, saracatinib, ZM.306416, bosutinib, TG.100572",0.371611069949688,0.226213555018806,FALSE +"H2009","Pearson.est","sterol demethylase inhibitor",-0.2719,-0.725,0.807,900,0.848,"posaconazole, terconazole",0.0931264652779296,0.0716041477432862,FALSE +"H2009","Pearson.est","TGF beta receptor inhibitor",-0.44492,-1.19,0.265,757,0.627,"adaprev, SB.431542, D.4476",0.576754126063192,0.202732459169284,FALSE +"H2009","Pearson.est","thymidylate synthase inhibitor",-0.66164,-1.77,0.0182,1205,0.761,"capecitabine, carmofur",1.73992861201493,0.118615343229427,FALSE +"H2009","Pearson.est","topoisomerase inhibitor",0.54886,1.65,0.0316,216,0.162,"voreloxin, idarubicin, valrubicin, mitoxantrone, amsacrine, TAS.103, etoposide, doxorubicin, teniposide, licochalcone.a, daunorubicin, dexrazoxane, epirubicin",1.5003129173816,0.790484985457369,TRUE +"H2009","Pearson.est","tubulin polymerization inhibitor",0.66033,1.98,0.0271,289,0.0844,"vinblastine, BNC105, CYT.997, mebendazole, vindesine, taltobulin, verubulin, KX2.391, podophyllotoxin, oxibendazole, vincristine, fenbendazole, fosbretabulin, parbendazole, flubendazole, dolastatin.10, ABT.751",1.56703070912559,1.07365755337434,TRUE +"H2009","Pearson.est","tyrosine kinase inhibitor",0.36255,1.08,0.347,376,0.569,"cabozantinib, sunitinib, UNC2250, bafetinib, regorafenib, aminopurvalanol.a, BMS.599626, NVP.TAE226, sorafenib, dasatinib, GTP.14564, AMG.208, hypericin, apatinib",0.459670525209126,0.244887733604929,FALSE +"H2009","Pearson.est","VEGFR inhibitor",0.56038,1.64,0.0632,291,0.154,"SU014813, cabozantinib, sunitinib, MK.2461, PD.173074, linifanib, MGCD.265, regorafenib, axitinib, tivozanib, ENMD.2076, pazopanib, cediranib, lenvatinib, dovitinib, nintedanib, vatalanib, KI.8751, sorafenib, golvatinib, foretinib",1.19928292171761,0.812479279163537,FALSE +"H2009","Pearson.est","vitamin D receptor agonist",0.52109,1.57,0.0531,124,0.181,"tacalcitol, alfacalcidol, doxercalciferol",1.27490547891853,0.742321425130815,FALSE +"H2126","Pearson.est","EGFR inhibitor",0.61179,1.55,0.056,348,0.331,"vandetanib, CP.724714, AZD8931, CUDC.101, icotinib, XL.647, gefitinib, lapatinib, neratinib, WZ.4002, erlotinib, BIBU.1361, BMS.690514, rociletinib, poziotinib, pelitinib, ARRY.334543, dacomitinib, FERb.033, osimertinib, CGP.52411, PD.168393, afatinib, AST.1306, WZ.3146, canertinib, BMS.599626",1.2518119729938,0.480172006224281,FALSE +"H2126","Pearson.est","Abl kinase inhibitor",0.60069,1.51,0.0715,375,0.338,"ponatinib, dasatinib, flumatinib, metatinib, tozasertib, GZD824, nilotinib, KW.2449, ZM.306416",1.14569395819892,0.471083299722345,FALSE +"H2126","Pearson.est","acetylcholine receptor agonist",0.60837,1.55,0.054,383,0.331,"pilocarpine, xanomeline, nefiracetam",1.26760624017703,0.480172006224281,FALSE +"H2126","Pearson.est","acetylcholine receptor antagonist",0.55623,1.41,0.102,409,0.449,"dicycloverine, diphemanil, methscopolamine, darifenacin",0.991399828238082,0.347753658996677,FALSE +"H2126","Pearson.est","adenosine receptor antagonist",0.46684,1.17,0.285,45,0.569,"sulmazole",0.54515513999149,0.244887733604929,FALSE +"H2126","Pearson.est","adrenergic receptor agonist",0.28327,0.726,0.788,366,0.926,"buphenine, oxymetazoline, A61603, epinephrine, clenbuterol, isoetharine",0.103473782510445,0.0333890133180656,FALSE +"H2126","Pearson.est","adrenergic receptor antagonist",0.34888,0.9,0.584,458,0.818,"propranolol, pindolol, dihydroergocristine, metoprolol, idazoxan, practolol, RS.17053, atipamezole, naftidrofuryl, vincamine",0.233587152887601,0.087246696328677,FALSE +"H2126","Pearson.est","AKT inhibitor",0.52511,1.32,0.16,429,0.551,"AT7867, uprosertib, palomid.529, ONC201, triciribine, GSK2110183, CCT128930",0.795880017344075,0.258848401148215,FALSE +"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.41234,1.06,0.417,462,0.641,"AP26113, DMH1, CEP.37440, NVP.TAE684, AZD3463",0.379863945026242,0.193141970481183,FALSE +"H2126","Pearson.est","androgen receptor antagonist",-0.51129,-1.51,0.0969,1282,0.275,"RU.58841, bicalutamide",1.01367622294923,0.560667306169737,FALSE +"H2126","Pearson.est","antioxidant",0.61827,1.57,0.0494,414,0.379,"taurine, benfotiamine, trolox, rutin",1.30627305107635,0.421360790031928,FALSE +"H2126","Pearson.est","AP inhibitor",-0.75408,-2.14,0.00746,1290,0.0347,"LCL.161, GDC.0152, birinapant, idronoxil",2.12726117252733,1.45967052520913,TRUE +"H2126","Pearson.est","ATPase inhibitor",0.37935,0.971,0.494,635,0.746,"digitoxin, digitoxigenin, omeprazole, blebbistatin...., ouabain, evodiamine, thonzonium, oligomycin.a, NMS.873",0.306273051076353,0.127261172527331,FALSE +"H2126","Pearson.est","Aurora kinase inhibitor",0.49381,1.27,0.202,702,0.575,"hesperadin, ENMD.2076, AMG900, MLN.8054, tozasertib, CYC116, danusertib, KW.2449, barasertib.HQPA, CCT129202, alisertib, AT.9283, MK.8745, PHA.680632, CCT137690, SNS.314, aurora.a.inhibitor.i, barasertib, GSK1070916, PF.03814735, ZM.447439",0.694648630553376,0.24033215531037,FALSE +"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.35964,-1.06,0.352,1155,0.514,"valnemulin, radezolid, dirithromycin, azithromycin",0.453457336521869,0.289036881004724,FALSE +"H2126","Pearson.est","bacterial DNA gyrase inhibitor",-0.3184,-0.92,0.519,1125,0.67,"finafloxacin, sarafloxacin, nadifloxacin, norfloxacin, trovafloxacin",0.284832642151542,0.173925197299174,FALSE +"H2126","Pearson.est","BCL inhibitor",-0.2858,-0.854,0.63,1320,0.709,"ABT.737, venetoclax",0.200659450546418,0.149353764816933,FALSE +"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.6109,1.54,0.0388,320,0.315,"ponatinib, dasatinib, flumatinib, metatinib, tozasertib, GZD824, nilotinib",1.41116827440579,0.501689446210399,FALSE +"H2126","Pearson.est","benzodiazepine receptor agonist",-0.42007,-1.22,0.208,1352,0.42,"temazepam, piperazine, gamma.aminobutyric.acid, eprinomectin",0.681936665037238,0.3767507096021,FALSE +"H2126","Pearson.est","bromodomain inhibitor",0.49891,1.27,0.188,541,0.575,"I.BET.762, JQ1...., OTX015",0.72584215073632,0.24033215531037,FALSE +"H2126","Pearson.est","calcium channel blocker",0.46203,1.19,0.249,364,0.573,"penfluridol, cinnarazine, mibefradil, pranidipine, tetrandrine",0.603800652904264,0.24184537803261,FALSE +"H2126","Pearson.est","CC chemokine receptor antagonist",0.343,0.874,0.623,17,0.824,"RS.504393",0.20551195334083,0.0840727883028842,FALSE +"H2126","Pearson.est","CDK inhibitor",0.25773,0.665,0.862,624,0.927,"indirubin, P276.00, R547, PHA.848125, ribociclib, palbociclib, AZD5438, aminopurvalanol.a, AT.7519, alvocidib, arcyriaflavin.a, abemaciclib",0.0644927341752872,0.0329202658555029,FALSE +"H2126","Pearson.est","CHK inhibitor",-0.63566,-1.87,0.0268,1185,0.113,"CHIR.124, AZD7762, PF.477736, SCH.900776",1.57186520597121,0.94692155651658,TRUE +"H2126","Pearson.est","cyclooxygenase inhibitor",0.35172,0.91,0.591,241,0.818,"piroxicam, tepoxalin, suxibuzone, acetylsalicylsalicylic.acid, ramifenazone, FR.122047",0.228412519118745,0.087246696328677,FALSE +"H2126","Pearson.est","cytochrome P450 inhibitor",0.65095,1.64,0.0235,433,0.339,"PF.4981517, morin, eplerenone, cobicistat",1.62893213772826,0.469800301796918,FALSE +"H2126","Pearson.est","DNA alkylating agent",0.34296,0.878,0.627,307,0.837,"dacarbazine, TH.302, ifosfamide",0.202732459169284,0.07727454200674,FALSE +"H2126","Pearson.est","DNA inhibitor",-0.35305,-0.983,0.413,1353,0.6,"sangivamycin, pibenzimol, nithiamide, chlorambucil",0.384049948343599,0.221848749616356,FALSE +"H2126","Pearson.est","DNA methyltransferase inhibitor",0.40856,1.04,0.408,469,0.643,"RG108, disulfiram",0.38933983691012,0.191789027075778,FALSE +"H2126","Pearson.est","DNA polymerase inhibitor",0.26508,0.674,0.851,305,0.934,"cephalomannine, menadione",0.0700704399154121,0.0296531237699066,FALSE +"H2126","Pearson.est","DNA synthesis inhibitor",0.21878,0.554,0.959,663,0.969,"CB.10.277, azodicarbonamide, nelarabine, estramustine.phosphate, anisomycin, cyclocytidine, altretamine, artesunate",0.0181813928293364,0.0136762229492347,FALSE +"H2126","Pearson.est","dopamine receptor antagonist",0.2228,0.568,0.948,155,0.977,"UH.232...., clebopride",0.0231916626619338,0.0101054362812269,FALSE +"H2126","Pearson.est","estrogen receptor agonist",0.54821,1.39,0.116,96,0.46,"estradiol.cypionate, ethinyl.estradiol",0.935542010773082,0.337242168318426,FALSE +"H2126","Pearson.est","estrogen receptor antagonist",0.41082,1.06,0.394,606,0.641,"tamoxifen, toremifene, raloxifene, clomifene, fulvestrant",0.404503778174426,0.193141970481183,FALSE +"H2126","Pearson.est","FGFR inhibitor",0.32957,0.843,0.643,139,0.842,"PD.173074, orantinib",0.191789027075778,0.0746879085003505,FALSE +"H2126","Pearson.est","FLT3 inhibitor",0.5888,1.48,0.063,374,0.37,"midostaurin, ponatinib, sorafenib, ENMD.2076, GTP.14564, quizartinib, pacritinib, tozasertib, gilteritinib, KW.2449, lestaurtinib",1.20065945054642,0.431798275933005,FALSE +"H2126","Pearson.est","glucocorticoid receptor agonist",0.31874,0.81,0.699,146,0.858,"methylprednisolone, betamethasone, fluticasone.propionate, prednisolone, dexamethasone.acetate",0.155522824254319,0.0665127121512946,FALSE +"H2126","Pearson.est","glutamate receptor antagonist",-0.41767,-1.2,0.259,1238,0.413,"diazooxonorleucine, CPP, CGP.37849, kynurenic.acid, JNJ.16259685, latrepirdine",0.586700235918748,0.384049948343599,FALSE +"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.42337,-1.19,0.262,1262,0.396,"CHIR.98014, LY2090314, CHIR.99021, kenpaullone",0.581698708680255,0.402304814074488,FALSE +"H2126","Pearson.est","growth factor receptor inhibitor",0.48476,1.21,0.24,620,0.556,"danusertib, lestaurtinib, PHA.848125, AZD3463, GSK1838705A",0.619788758288394,0.254925208417942,FALSE +"H2126","Pearson.est","HCV inhibitor",-0.5657,-1.64,0.0395,1269,0.234,"PSI.7976, daclatasvir, Ro.9187",1.40340290437354,0.630784142589857,TRUE +"H2126","Pearson.est","HDAC inhibitor",0.48541,1.21,0.254,485,0.556,"belinostat, resminostat, nexturastat.a, M.344, ACY.1215, panobinostat, chidamide, RG2833, vorinostat, RGFP966, mocetinostat, givinostat, tacedinaline, PCI.24781",0.595166283380062,0.254925208417942,FALSE +"H2126","Pearson.est","histamine receptor antagonist",0.47728,1.21,0.25,509,0.556,"pheniramine, tiotidine, ranitidine, BF2.649, lafutidine, terfenadine, ebastine, ICI.162846, levocetirizine, tecastemizole, famotidine",0.602059991327962,0.254925208417942,FALSE +"H2126","Pearson.est","HMGCR inhibitor",-0.44304,-1.26,0.196,1437,0.447,"lovastatin",0.707743928643524,0.349692476868064,FALSE +"H2126","Pearson.est","HSP inhibitor",-0.233,-0.665,0.881,1316,0.867,"alvespimycin, SNX.2112, VER.49009",0.0550240915879521,0.0619809025237897,FALSE +"H2126","Pearson.est","JAK inhibitor",0.4446,1.14,0.314,501,0.586,"ruxolitinib, pacritinib, PRT062070, CEP.33779, tozasertib, lestaurtinib, TG.101209, atiprimod, AZ960, AT.9283",0.503070351926785,0.232102383981909,FALSE +"H2126","Pearson.est","KIT inhibitor",0.46842,1.21,0.242,259,0.556,"midostaurin, masitinib, sorafenib, dasatinib, pazopanib, motesanib",0.616184634019569,0.254925208417942,FALSE +"H2126","Pearson.est","MDM inhibitor",-0.56252,-1.59,0.0581,1223,0.239,"serdemetan, CGM097, AMG.232, idasanutlin",1.23582386760967,0.621602099051862,FALSE +"H2126","Pearson.est","MEK inhibitor",-0.46123,-1.36,0.161,1157,0.36,"selumetinib, TAK.733, PD.318088, cobimetinib, AS.703026, PD.184352, trametinib, refametinib",0.79317412396815,0.443697499232713,FALSE +"H2126","Pearson.est","MET inhibitor",-0.40796,-1.24,0.216,1275,0.431,"INC.280, PF.04217903",0.665546248849069,0.365522729839268,FALSE +"H2126","Pearson.est","microtubule inhibitor",0.43088,1.08,0.376,589,0.64,"secnidazole, cabazitaxel, D.64131, estramustine.phosphate, cytochalasin.b, vinflunine",0.424812155072339,0.193820026016113,FALSE +"H2126","Pearson.est","mTOR inhibitor",0.37139,0.942,0.528,515,0.78,"GSK2126458, everolimus, temsirolimus, AZD2014, LY3023414, deforolimus, palomid.529, PI.103, WYE.125132, AZD8055, NVP.BEZ235, torin.1, MLN0128, torin.2, WYE.354, PF.05212384",0.277366077466188,0.10790539730952,FALSE +"H2126","Pearson.est","NFkB pathway inhibitor",-0.24662,-0.728,0.799,1136,0.824,"curcumin, IKK.2.inhibitor.V, bortezomib, tyloxapol, bindarit",0.0974532206860086,0.0840727883028842,FALSE +"H2126","Pearson.est","opioid receptor agonist",0.49199,1.24,0.233,735,0.588,"salvinorin.a, spiradoline, BW.180C, ADL5859, trimebutine, cebranopadol",0.632644078973981,0.230622673923862,FALSE +"H2126","Pearson.est","p38 MAPK inhibitor",0.70848,1.78,0.0202,379,0.306,"VX.702, TAK.715, SB.242235, talmapimod, CMPD.1",1.69464863055338,0.51427857351842,FALSE +"H2126","Pearson.est","PARP inhibitor",0.45429,1.16,0.281,790,0.57,"PJ.34, E7449, AZD2461, olaparib, endo.IWR.1, niraparib, talazoparib, AG.14361",0.55129368009492,0.244125144327509,FALSE +"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.46661,1.18,0.262,259,0.571,"masitinib, ponatinib, sorafenib, orantinib, dasatinib, axitinib, pazopanib, motesanib",0.581698708680255,0.243363891754152,FALSE +"H2126","Pearson.est","phosphatase inhibitor",0.26917,0.683,0.846,511,0.96,"sodium.stibogluconate, mycophenolic.acid, menadione, bis.maltolato.oxovanadium.IV., CID.5458317",0.0726296369609765,0.0177287669604316,FALSE +"H2126","Pearson.est","phosphodiesterase inhibitor",0.5398,1.36,0.131,380,0.496,"YM.976, GSK256066, cilostamide, enoximone",0.882728704344236,0.304518323509803,FALSE +"H2126","Pearson.est","PI3K inhibitor",0.32877,0.837,0.667,778,0.833,"GSK2126458, LY3023414, YM.201636, alpelisib, PI.103, GDC.0941, NVP.BEZ235, buparlisib, PF.05212384, GDC.0980, PKI.179, TG.100713, taselisib, BGT226, PI.828, PIK.75, voxtalisib, CH5132799, PI3K.IN.2, CUDC.907",0.175874166083451,0.0793549985932124,FALSE +"H2126","Pearson.est","PLK inhibitor",0.42473,1.09,0.362,764,0.641,"volasertib, NMS.1286937, HMN.214, GW.843682X, rigosertib, GSK461364",0.441291429466834,0.193141970481183,FALSE +"H2126","Pearson.est","potassium channel blocker",-0.30585,-0.866,0.586,1314,0.726,"dofetilide, mepivacaine",0.232102383981909,0.139063379299906,FALSE +"H2126","Pearson.est","PPAR receptor agonist",-0.37267,-1.07,0.363,1281,0.533,"clofibrate, pterostilbene",0.440093374963888,0.273272790973428,FALSE +"H2126","Pearson.est","progesterone receptor agonist",-0.5085,-1.5,0.076,1344,0.251,"danazol, norgestrel, norethindrone.acetate",1.11918640771921,0.600326278518962,FALSE +"H2126","Pearson.est","proteasome inhibitor",-0.75506,-2.2,0,1082,0.0347,"ixazomib.citrate, ixazomib, delanzomib, bortezomib, MG.132, ONX.0914, carfilzomib, oprozomib",Inf,1.45967052520913,TRUE +"H2126","Pearson.est","protein synthesis inhibitor",0.26486,0.677,0.848,159,0.948,"tedizolid.phosphate, cycloheximide",0.0716041477432862,0.0231916626619338,FALSE +"H2126","Pearson.est","protein tyrosine kinase inhibitor",0.57641,1.46,0.0803,443,0.379,"CP.724714, NVP.TAE226, PP.121, BMS.599626, AV.412",1.09528445472132,0.421360790031928,FALSE +"H2126","Pearson.est","RAF inhibitor",0.29654,0.75,0.789,108,0.912,"SB.590885, sorafenib",0.10292299679058,0.0400051616715838,FALSE +"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.7394,1.85,0.00974,208,0.351,"vandetanib, sorafenib, apatinib",2.01144104312138,0.454692883534176,FALSE +"H2126","Pearson.est","retinoid receptor agonist",0.30224,0.766,0.764,497,0.908,"adapalene, CD.437, bexarotene, adarotene",0.11690664142431,0.0419141514789149,FALSE +"H2126","Pearson.est","ribonucleotide reductase inhibitor",-0.28654,-0.84,0.611,1302,0.696,"cytarabine, cladribine",0.213958789757446,0.157390760389438,FALSE +"H2126","Pearson.est","serotonin receptor antagonist",0.20012,0.507,0.99,51,0.975,"SB.216641",0.00436480540245009,0.0109953843014632,FALSE +"H2126","Pearson.est","sodium channel blocker",0.41512,1.05,0.411,290,0.642,"oxcarbazepine, brivaracetam, benzocaine, quinidine, A.803467",0.386158178123931,0.192464971931147,FALSE +"H2126","Pearson.est","src inhibitor",0.63945,1.62,0.0321,375,0.323,"masitinib, saracatinib, dasatinib, TG.100572, ZM.306416",1.49349496759513,0.490797477668897,FALSE +"H2126","Pearson.est","sterol demethylase inhibitor",0.66141,1.72,0.0224,64,0.238,"lanoconazole, ketoconazole, chlormidazole",1.64975198166584,0.623423042943488,TRUE +"H2126","Pearson.est","TGF beta receptor inhibitor",0.68001,1.72,0.0124,339,0.238,"D.4476, adaprev, SB.431542, repsox",1.90657831483776,0.623423042943488,TRUE +"H2126","Pearson.est","thymidylate synthase inhibitor",0.33925,0.863,0.618,136,0.825,"ftorafur",0.209011524911184,0.0835460514500749,FALSE +"H2126","Pearson.est","topoisomerase inhibitor",0.23898,0.603,0.901,577,0.969,"doxorubicin, amsacrine, mitoxantrone, epirubicin, etoposide, valrubicin, amonafide, dexrazoxane, voreloxin, rubitecan",0.045275209020937,0.0136762229492347,FALSE +"H2126","Pearson.est","tubulin polymerization inhibitor",0.43504,1.09,0.344,723,0.641,"nocodazole, epothilone.d, vincristine, ABT.751, fosbretabulin, paclitaxel, taltobulin, epothilone.b, docetaxel, indibulin, BNC105, albendazole, mebendazole, vindesine, dolastatin.10, parbendazole, flubendazole, plinabulin, vinorelbine, vinblastine",0.46344155742847,0.193141970481183,FALSE +"H2126","Pearson.est","tyrosine kinase inhibitor",0.5243,1.31,0.172,208,0.543,"vandetanib, CP.724714, NVP.TAE226, sorafenib, GTP.14564, dasatinib, PP.121, apatinib",0.764471553092451,0.265200170411153,FALSE +"H2126","Pearson.est","VEGFR inhibitor",0.49558,1.24,0.228,375,0.588,"semaxanib, vandetanib, XL.647, sorafenib, ENMD.2076, PD.173074, orantinib, BMS.690514, axitinib, pazopanib, motesanib, SAR131675, TG.100572, tivozanib, ZM.306416",0.642065152999546,0.230622673923862,FALSE +"H2126","Pearson.est","vitamin D receptor agonist",-0.76081,-2.26,0,1091,0.0459,"calcitriol, tacalcitol, ercalcitriol, maxacalcitol, alfacalcidol, paricalcitol, doxercalciferol",Inf,1.33818731446274,TRUE +"H3255","Pearson.est","EGFR inhibitor",0.15854,0.469,0.996,172,0.991,"dovitinib, icotinib, brigatinib, gefitinib, ARRY.334543, erlotinib, rociletinib",0.00174066157630127,0.00392634551472468,FALSE +"H3255","Pearson.est","Abl kinase inhibitor",-0.33503,-0.887,0.601,1069,1,"ZM.306416, flumatinib, KW.2449, metatinib",0.22112552799726,0,FALSE +"H3255","Pearson.est","acetylcholine receptor agonist",-0.45432,-1.23,0.223,826,0.801,"tremorine, nefiracetam, xanomeline, nicotine",0.651695136951839,0.0963674839157623,FALSE +"H3255","Pearson.est","acetylcholine receptor antagonist",-0.5721,-1.53,0.0735,918,0.463,"darifenacin, diphemanil, hyoscyamine",1.1337126609158,0.334419008982047,FALSE +"H3255","Pearson.est","adenosine receptor antagonist",-0.20525,-0.547,0.944,736,0.99,"PSB.1115, theophylline, sulmazole, istradefylline",0.025028005701931,0.00436480540245009,FALSE +"H3255","Pearson.est","adrenergic receptor agonist",-0.3923,-1.06,0.383,846,0.982,"isoetharine, A61603, buphenine, norepinephrine, metaraminol, methyldopa, xylazine",0.416801226031377,0.00788851221305034,FALSE +"H3255","Pearson.est","adrenergic receptor antagonist",-0.27974,-0.758,0.752,881,0.913,"dihydroergocristine, vincamine, atenolol...., atenolol......, oxprenolol, metoprolol, dronedarone, imiloxan",0.123782159408358,0.039529222465701,FALSE +"H3255","Pearson.est","AKT inhibitor",0.26309,0.855,0.617,204,0.936,"uprosertib, AZD5363, AT7867, ONC201",0.209714835966758,0.0287241512618947,FALSE +"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.32129,0.976,0.469,338,0.84,"brigatinib, alectinib, lorlatinib, SB.505124, crizotinib, NVP.TAE684",0.328827157284917,0.0757207139381184,FALSE +"H3255","Pearson.est","antioxidant",-0.50424,-1.33,0.164,1047,0.632,"taurine, mesna, benfotiamine, rutin",0.785156151952302,0.199282921717615,FALSE +"H3255","Pearson.est","AP inhibitor",-0.58639,-1.59,0.0597,1178,0.392,"birinapant, GDC.0152, tanshinone.i, embelin",1.22402566887063,0.406713932979543,FALSE +"H3255","Pearson.est","ATPase inhibitor",0.22783,0.749,0.748,230,0.988,"omeprazole, evodiamine, digitoxigenin",0.126098402135539,0.00524305541237188,FALSE +"H3255","Pearson.est","Aurora kinase inhibitor",-0.38298,-1.03,0.426,971,0.932,"SNS.314, danusertib, CCT137690, PF.03814735, PHA.680632, AT.9283, KW.2449, MK.8745, GSK1070916, CCT129202",0.370590400897281,0.0305840876460186,FALSE +"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.66387,-1.79,0.00691,1253,0.636,"tedizolid, radezolid, josamycin, dirithromycin, tilmicosin",2.1605219526258,0.196542884351586,FALSE +"H3255","Pearson.est","bacterial DNA gyrase inhibitor",0.23421,0.755,0.752,1087,1,"lomefloxacin, sparfloxacin, nadifloxacin, trovafloxacin, novobiocin, norfloxacin, finafloxacin, sarafloxacin",0.123782159408358,0,FALSE +"H3255","Pearson.est","BCL inhibitor",0.32576,1.03,0.401,958,0.919,"oridonin, obatoclax, TW.37, venetoclax, gossypol, navitoclax, ABT.737, HA14.1",0.396855627379818,0.0366844886138887,FALSE +"H3255","Pearson.est","Bcr.Abl kinase inhibitor",-0.19439,-0.515,0.963,1109,0.969,"flumatinib, metatinib",0.0163737128754655,0.0136762229492347,FALSE +"H3255","Pearson.est","benzodiazepine receptor agonist",-0.20771,-0.556,0.937,861,1,"eprinomectin, nefiracetam, piperazine, lorazepam, temazepam, ivermectin",0.0282604091122217,0,FALSE +"H3255","Pearson.est","bromodomain inhibitor",-0.39989,-1.07,0.382,1329,1,"OTX015, JQ1....",0.417936637088291,0,FALSE +"H3255","Pearson.est","calcium channel blocker",-0.39452,-1.06,0.393,1227,0.982,"SKF.96365, mibefradil, cinnarazine",0.405607449624573,0.00788851221305034,FALSE +"H3255","Pearson.est","CC chemokine receptor antagonist",-0.41879,-1.12,0.317,1269,1,"navarixin, PF.04136309",0.498940737782249,0,FALSE +"H3255","Pearson.est","CDK inhibitor",0.2276,0.708,0.817,352,0.96,"abemaciclib, ribociclib, indirubin, indisulam, R547, dinaciclib, PHA.848125, AT.7519, P276.00",0.0877779434675845,0.0177287669604316,FALSE +"H3255","Pearson.est","CHK inhibitor",-0.6328,-1.68,0.0211,1010,0.341,"SB.218078, SCH.900776, CHIR.124, PF.477736, AZD7762",1.67571754470231,0.467245621007502,FALSE +"H3255","Pearson.est","cyclooxygenase inhibitor",-0.29705,-0.779,0.737,662,0.925,"ketoprofen, ramifenazone, amfenac, aspirin, phenylbutazone, piroxicam, FK.3311, indoprofen, FR.122047, phenazone, acetylsalicylsalicylic.acid, suxibuzone, naproxen",0.132532512140949,0.0338582672609674,FALSE +"H3255","Pearson.est","cytochrome P450 inhibitor",-0.30168,-0.794,0.724,1014,0.946,"clotrimazole, cobicistat, morin",0.140261433802853,0.0241088635982073,FALSE +"H3255","Pearson.est","DNA alkylating agent",-0.37024,-0.986,0.469,951,0.898,"melphalan, carboplatin, carmustine, satraplatin, streptozotocin, ifosfamide, cyclophosphamide, temozolomide",0.328827157284917,0.0467236633326956,FALSE +"H3255","Pearson.est","DNA inhibitor",-0.4167,-1.11,0.344,927,1,"oxaliplatin, nimorazole, nithiamide, melphalan, carboplatin, bendamustine, carmustine, teroxirone, mechlorethamine, busulfan",0.46344155742847,0,FALSE +"H3255","Pearson.est","DNA methyltransferase inhibitor",-0.31866,-0.864,0.649,998,1,"RG108, SGI.1027, fdcyd",0.187755303199631,0,FALSE +"H3255","Pearson.est","DNA polymerase inhibitor",-0.59694,-1.62,0.0347,1012,0.399,"idoxuridine, foscarnet, cidofovir, adefovir.dipivoxil, trifluridine",1.45967052520913,0.399027104313252,FALSE +"H3255","Pearson.est","DNA synthesis inhibitor",-0.38142,-1.02,0.43,779,0.885,"mitomycin.c, CB.10.277, azodicarbonamide, enocitabine, artemisinin, artesunate, floxuridine, nelarabine",0.366531544420413,0.0530567293021746,FALSE +"H3255","Pearson.est","dopamine receptor antagonist",-0.24624,-0.658,0.855,791,0.957,"UH.232...., acetophenazine, piperacetazine, isofloxythepin, amisulpride, domperidone, raclopride",0.0680338852718274,0.0190880622231565,FALSE +"H3255","Pearson.est","estrogen receptor agonist",-0.51548,-1.41,0.113,960,0.58,"equol, PPT, estradiol.cypionate, estrone, estradiol",0.94692155651658,0.236572006437063,FALSE +"H3255","Pearson.est","estrogen receptor antagonist",-0.30441,-0.805,0.699,653,0.977,"tamoxifen, clomifene, fulvestrant, danazol, raloxifene",0.155522824254319,0.0101054362812269,FALSE +"H3255","Pearson.est","FGFR inhibitor",0.3454,1.09,0.348,54,0.849,"dovitinib, regorafenib, PD.173074",0.458420756053419,0.0710923097560473,FALSE +"H3255","Pearson.est","FLT3 inhibitor",0.43744,1.34,0.16,42,0.554,"sorafenib, ENMD.2076, dovitinib, sunitinib, pacritinib",0.795880017344075,0.25649023527157,FALSE +"H3255","Pearson.est","glucocorticoid receptor agonist",-0.37853,-1.01,0.447,744,0.875,"piretanide, fluocinolone.acetonide, difluprednate, halcinonide, flumethasone, rimexolone, beclomethasone.dipropionate, fluorometholone, fluticasone.propionate, halobetasol.propionate, prednisolone, triamcinolone, prednisolone.hemisuccinate, methylprednisolone",0.349692476868064,0.0579919469776868,FALSE +"H3255","Pearson.est","glutamate receptor antagonist",0.22719,0.723,0.823,201,0.982,"CPP, MTPG, felbamate, CGP.37849",0.0846001647877302,0.00788851221305034,FALSE +"H3255","Pearson.est","glycogen synthase kinase inhibitor",-0.2997,-0.797,0.708,1148,0.965,"CHIR.98014, tideglusib, kenpaullone",0.149966742310231,0.0154726866562074,FALSE +"H3255","Pearson.est","growth factor receptor inhibitor",-0.38846,-1.04,0.419,896,0.947,"GW.441756, AZD3463, danusertib, GSK1904529A, lestaurtinib",0.377785977033705,0.0236500209967266,FALSE +"H3255","Pearson.est","HDAC inhibitor",0.41179,1.26,0.189,266,0.56,"vorinostat, tacedinaline, resminostat, scriptaid, romidepsin, entinostat, JNJ.26481585, nexturastat.a, panobinostat, AR.42, dacinostat",0.723538195826756,0.2518119729938,FALSE +"H3255","Pearson.est","histamine receptor antagonist",-0.2882,-0.785,0.714,703,0.938,"ICI.162846, BF2.649, levocetirizine, ebastine, pheniramine, tecastemizole, famotidine, cimetidine, terfenadine, nizatidine, ranitidine",0.146301788223826,0.0277971616209356,FALSE +"H3255","Pearson.est","HSP inhibitor",-0.30528,-0.824,0.673,1187,1,"guanidine, SNX.5422, XL888, NMS.E973",0.171984935776023,0,FALSE +"H3255","Pearson.est","JAK inhibitor",-0.49323,-1.33,0.141,1124,0.632,"AT.9283, TG.101348, baricitinib, TG.101209, LY2784544, lestaurtinib, CEP.33779, atiprimod",0.85078088734462,0.199282921717615,FALSE +"H3255","Pearson.est","KIT inhibitor",0.5161,1.61,0.0376,183,0.503,"sorafenib, sunitinib, regorafenib, motesanib, imatinib, vatalanib",1.42481215507234,0.298432014944073,FALSE +"H3255","Pearson.est","MDM inhibitor",-0.37274,-1.02,0.433,615,0.885,"CGM097, serdemetan, RITA, AMG.232, nutlin.3",0.363512103646635,0.0530567293021746,FALSE +"H3255","Pearson.est","MEK inhibitor",-0.46026,-1.26,0.197,776,0.771,"trametinib, AZD8330, PD.98059, refametinib, U.0126, PD.318088, PD.184352, PD.0325901, TAK.733, selumetinib, AS.703026, MEK162, MEK1.2.inhibitor, arctigenin",0.705533773838407,0.112945621949043,FALSE +"H3255","Pearson.est","MET inhibitor",0.67423,2.11,0.00837,300,0.104,"LY2801653, PF.04217903, INC.280, AMG458",2.07727454200674,0.98296666070122,TRUE +"H3255","Pearson.est","microtubule inhibitor",0.41649,1.29,0.14,831,0.569,"cytochalasin.b, colchicine, secnidazole, vinblastine, triclabendazole, vinflunine, cabazitaxel, estramustine.phosphate, D.64131, podophyllotoxin",0.853871964321762,0.244887733604929,FALSE +"H3255","Pearson.est","mTOR inhibitor",-0.39896,-1.06,0.375,902,0.982,"ku.0063794, voxtalisib, WYE.125132, sirolimus, MLN0128, everolimus, LY303511, temsirolimus, AZD2014, torin.1, LY3023414, torin.2, PP242, PKI.179, deforolimus, AZD8055",0.425968732272281,0.00788851221305034,FALSE +"H3255","Pearson.est","NFkB pathway inhibitor",0.22033,0.679,0.871,283,0.917,"BAY.11.7082, curcumin, parthenolide...., bindarit",0.0599818449923368,0.0376306643299789,FALSE +"H3255","Pearson.est","opioid receptor agonist",-0.66194,-1.76,0.0137,1288,0.392,"ADL5859, cebranopadol",1.86327943284359,0.406713932979543,FALSE +"H3255","Pearson.est","p38 MAPK inhibitor",-0.56341,-1.52,0.0686,1081,0.426,"talmapimod, VX.702, SB.239063, CMPD.1, SB.242235",1.16367588429325,0.370590400897281,FALSE +"H3255","Pearson.est","PARP inhibitor",-0.27392,-0.732,0.782,851,0.929,"endo.IWR.1, AZD2461, E7449",0.106793246940152,0.0319842860063582,FALSE +"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.53436,1.58,0.0656,219,0.42,"sorafenib, axitinib, dovitinib, sunitinib, regorafenib, motesanib, SU014813, imatinib, CP.673451, vatalanib, trapidil",1.18309616062434,0.3767507096021,FALSE +"H3255","Pearson.est","phosphatase inhibitor",-0.2027,-0.54,0.955,868,0.975,"alexidine, BVT.948, mycophenolate.mofetil, mycophenolic.acid",0.0199966284162537,0.0109953843014632,FALSE +"H3255","Pearson.est","phosphodiesterase inhibitor",0.32397,1.02,0.385,128,0.865,"trequinsin, enoximone, anagrelide",0.414539270491499,0.0629838925351858,FALSE +"H3255","Pearson.est","PI3K inhibitor",0.21982,0.701,0.862,253,0.928,"idelalisib, GSK2126458, pilaralisib, YM.201636, PI.103, buparlisib, AZD6482, CH5132799, PI.828, SB.2343",0.0644927341752872,0.0324520237811379,FALSE +"H3255","Pearson.est","PLK inhibitor",0.27961,0.865,0.585,264,0.971,"GW.843682X, GSK461364, rigosertib",0.23284413391782,0.0127807700919951,FALSE +"H3255","Pearson.est","potassium channel blocker",0.18852,0.591,0.93,1151,0.97,"dofetilide, meglitinide, ibutilide, oleoylethanolamide, mepivacaine, ML133",0.0315170514460649,0.0132282657337552,FALSE +"H3255","Pearson.est","PPAR receptor agonist",-0.38895,-1.04,0.416,1291,0.947,"S26948, clofibrate",0.380906669373257,0.0236500209967266,FALSE +"H3255","Pearson.est","progesterone receptor agonist",-0.28552,-0.772,0.757,800,0.914,"melengestrol.acetate, norgestrel, danazol, tanaproget, nomegestrol.acetate",0.120904120499927,0.0390538042661686,FALSE +"H3255","Pearson.est","proteasome inhibitor",-0.51001,-1.38,0.122,976,0.608,"oprozomib, bortezomib, ixazomib, ixazomib.citrate, delanzomib",0.913640169325252,0.216096420727265,FALSE +"H3255","Pearson.est","protein synthesis inhibitor",0.2771,0.847,0.657,854,0.9,"brefeldin.a, cycloheximide, harringtonine, chloramphenicol.palmitate, emetine, anguidine, homoharringtonine, azomycin..2.nitroimidazole., bruceantin, tedizolid.phosphate, puromycin, mercaptopurine, clofoctol, thiostrepton, florfenicol, clindamycin.phosphate",0.182434630440219,0.0457574905606751,FALSE +"H3255","Pearson.est","protein tyrosine kinase inhibitor",-0.54805,-1.47,0.0839,824,0.485,"CP.724714, NVP.TAE226, PP.121, tyrphostin.A9, BMS.599626, mubritinib, AV.412",1.0762380391713,0.314258261397736,FALSE +"H3255","Pearson.est","RAF inhibitor",-0.21641,-0.593,0.926,825,0.999,"SB.590885, PLX.4720, GDC.0879, TAK.632, CEP.32496, LGX818, dabrafenib",0.0333890133180656,0.000434511774017692,FALSE +"H3255","Pearson.est","RET tyrosine kinase inhibitor",0.8246,2.58,0,43,0.00255,"sorafenib, sunitinib, cabozantinib, regorafenib",Inf,2.59345981956604,TRUE +"H3255","Pearson.est","retinoid receptor agonist",0.49644,1.52,0.0988,137,0.421,"adapalene, bexarotene, AM.580",1.00524305541237,0.375717904164332,FALSE +"H3255","Pearson.est","ribonucleotide reductase inhibitor",-0.35131,-0.936,0.53,657,0.943,"fludarabine.phosphate, fludarabine, cytarabine, LY2334737, triapine, gemcitabine, clofarabine",0.275724130399211,0.0254883072626717,FALSE +"H3255","Pearson.est","serotonin receptor antagonist",-0.25932,-0.694,0.837,869,0.957,"SB.228357, RS.16566, lerisetron, SB.216641, SB.200646",0.07727454200674,0.0190880622231565,FALSE +"H3255","Pearson.est","sodium channel blocker",-0.30567,-0.815,0.682,753,0.984,"butamben, lappaconite, brivaracetam, oxcarbazepine, mepivacaine, triamterene, quinidine, ajmaline, benzethonium",0.166215625343521,0.00700490156865849,FALSE +"H3255","Pearson.est","src inhibitor",-0.25107,-0.684,0.843,812,0.948,"TG.100572, KX2.391, PP.2, ZM.306416",0.0741724253752577,0.0231916626619338,FALSE +"H3255","Pearson.est","sterol demethylase inhibitor",-0.30566,-0.825,0.683,1174,1,"lanoconazole, posaconazole",0.165579296318467,0,FALSE +"H3255","Pearson.est","TGF beta receptor inhibitor",-0.64232,-1.73,0.0173,1352,0.321,"adaprev, SB.525334, LY2109761",1.7619538968712,0.493494967595128,FALSE +"H3255","Pearson.est","thymidylate synthase inhibitor",-0.30585,-0.817,0.694,844,1,"ftorafur, carmofur, raltitrexed, trifluridine",0.158640529545145,0,FALSE +"H3255","Pearson.est","topoisomerase inhibitor",-0.30546,-0.834,0.638,654,1,"nemorubicin, exatecan.mesylate, doxorubicin, etoposide.phosphate, amsacrine, etoposide, rubitecan, valrubicin, idarubicin, camptothecin, mitoxantrone, irinotecan, teniposide, topotecan, fleroxacin, amonafide, genz.644282, voreloxin, TAS.103, SN.38",0.195179321278838,0,FALSE +"H3255","Pearson.est","tubulin polymerization inhibitor",0.32322,0.99,0.415,299,0.868,"mebendazole, vinorelbine, nocodazole, docetaxel, verubulin, paclitaxel, fosbretabulin, parbendazole, vindesine, BNC105, vincristine",0.381951903287907,0.0614802748235081,FALSE +"H3255","Pearson.est","tyrosine kinase inhibitor",0.311,0.959,0.494,88,0.82,"sorafenib, sunitinib, cabozantinib, regorafenib, tyrphostin.AG.99",0.306273051076353,0.0861861476162833,FALSE +"H3255","Pearson.est","VEGFR inhibitor",0.47776,1.4,0.11,209,0.526,"sorafenib, axitinib, ENMD.2076, dovitinib, sunitinib, cabozantinib, regorafenib, motesanib, SU014813, PD.173074, tivozanib, semaxanib, vatalanib, MK.2461, MGCD.265",0.958607314841775,0.279014255846261,FALSE +"H3255","Pearson.est","vitamin D receptor agonist",-0.36014,-0.963,0.497,880,0.915,"alfacalcidol, calcitriol, doxercalciferol, tacalcitol, ercalcitriol",0.303643611266668,0.0385789059335517,FALSE +"H358","Pearson.est","EGFR inhibitor",-0.37886,-1.1,0.321,867,0.517,"WZ.4002, BIBU.1361, erlotinib, tyrphostin.AG.1478, lapatinib, dacomitinib, AZD8931, ARRY.334543, FERb.033, afatinib, pelitinib, poziotinib, PD.168393, dovitinib, osimertinib, neratinib, tyrphostin.AG.494, vandetanib, BIBX.1382, BMS.690514, canertinib",0.493494967595128,0.286509456906058,FALSE +"H358","Pearson.est","Abl kinase inhibitor",0.50577,1.33,0.154,414,0.463,"GZD824, metatinib, flumatinib, KW.2449, imatinib, tozasertib, nilotinib",0.812479279163537,0.334419008982047,FALSE +"H358","Pearson.est","adenosine receptor antagonist",-0.7832,-2.23,0.00279,1118,0.0226,"theophylline, sulmazole, SCH.58261, PSB.1115",2.5543957967264,1.6458915608526,TRUE +"H358","Pearson.est","adrenergic receptor agonist",-0.49644,-1.43,0.129,1141,0.484,"ritodrine, A61603, isoetharine, xylazine",0.889410289700751,0.315154638355588,FALSE +"H358","Pearson.est","adrenergic receptor antagonist",-0.29941,-0.837,0.658,1013,0.789,"pindolol, RS.17053, prazosin, atenolol....",0.181774106386044,0.10292299679058,FALSE +"H358","Pearson.est","AKT inhibitor",0.39081,1.04,0.421,459,0.639,"GDC.0068, MK.2206, A.674563, CCT128930, AZD5363, uprosertib, triciribine",0.375717904164332,0.1944991418416,FALSE +"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.48722,-1.38,0.133,1031,0.494,"GW.788388, AZD3463, CEP.37440, crizotinib, SB.505124",0.876148359032914,0.306273051076353,FALSE +"H358","Pearson.est","antioxidant",-0.82175,-2.34,0,1056,0.0164,"rutin, taurine, chlorogenic.acid, benfotiamine, trolox",Inf,1.7851561519523,TRUE +"H358","Pearson.est","ATPase inhibitor",0.56153,1.48,0.0887,482,0.624,"ouabain, NMS.873, blebbistatin...., thonzonium, digitoxigenin",1.05207638016827,0.204815410317576,FALSE +"H358","Pearson.est","Aurora kinase inhibitor",0.65107,1.72,0.024,371,1,"barasertib.HQPA, SNS.314, CYC116, PF.03814735, danusertib, AMG900, ZM.447439, MK.5108, CCT129202, ENMD.2076, barasertib, TAK.901, CCT137690, PHA.680632, aurora.a.inhibitor.i, KW.2449, tozasertib, AT.9283",1.61978875828839,0,FALSE +"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.2921,0.785,0.729,8,0.811,"tedizolid",0.137272471682025,0.090979145788844,FALSE +"H358","Pearson.est","bacterial DNA gyrase inhibitor",0.36916,0.988,0.448,319,0.68,"trovafloxacin, sarafloxacin",0.348721986001856,0.167491087293764,FALSE +"H358","Pearson.est","BCL inhibitor",0.5106,1.35,0.15,206,0.459,"HA14.1, TW.37, ABT.737, venetoclax",0.823908740944319,0.338187314462739,FALSE +"H358","Pearson.est","Bcr.Abl kinase inhibitor",0.5405,1.43,0.105,414,0.52,"GZD824, metatinib, flumatinib, imatinib, tozasertib, nilotinib",0.978810700930062,0.283996656365201,FALSE +"H358","Pearson.est","benzodiazepine receptor agonist",-0.36214,-1.04,0.402,902,0.546,"zaleplon, temazepam, CGS.20625, nefiracetam, gamma.aminobutyric.acid",0.39577394691553,0.262807357295263,FALSE +"H358","Pearson.est","calcium channel blocker",0.4579,1.23,0.214,536,0.468,"SKF.96365, mibefradil, SR.33805, tetrandrine, pranidipine, carboxyamidotriazole, penfluridol, efonidipine.monoethanolate",0.669586226650809,0.329754146925876,FALSE +"H358","Pearson.est","CC chemokine receptor antagonist",0.29196,0.778,0.72,395,0.801,"RS.504393, ZK811752, SB.225002",0.142667503568732,0.0963674839157623,FALSE +"H358","Pearson.est","CDK inhibitor",0.49328,1.3,0.173,315,0.406,"kenpaullone, AZD5438, BMS.387032, alvocidib, TG.02, BMS.265246, indisulam, AT.7519, aminopurvalanol.a, P276.00, dinaciclib",0.761953896871205,0.391473966422806,FALSE +"H358","Pearson.est","CHK inhibitor",0.36529,0.968,0.492,238,0.669,"PF.477736, CHIR.124, AZD7762",0.30803489723264,0.174573882232177,FALSE +"H358","Pearson.est","cyclooxygenase inhibitor",0.30963,0.816,0.671,305,0.806,"piroxicam, amfenac, acetylsalicylsalicylic.acid, curcumin, tryptanthrin",0.173277479831008,0.0936649581949093,FALSE +"H358","Pearson.est","cytochrome P450 inhibitor",-0.71831,-2.03,0.0141,1038,0.0716,"metyrapone, PF.4981517, eplerenone, morin",1.85078088734462,1.14508697769214,TRUE +"H358","Pearson.est","DNA alkylating agent",-0.29116,-0.827,0.648,1088,0.769,"carboplatin, ifosfamide, dacarbazine, cisplatin",0.188424994129407,0.114073660198569,FALSE +"H358","Pearson.est","DNA inhibitor",0.32207,0.859,0.632,330,0.782,"melphalan, chlorambucil, pibenzimol, valrubicin, oxaliplatin, primaquine",0.199282921717615,0.106793246940152,FALSE +"H358","Pearson.est","DNA methyltransferase inhibitor",0.44101,1.16,0.293,611,0.532,"disulfiram, fdcyd, decitabine, azacitidine",0.533132379645891,0.274088367704952,FALSE +"H358","Pearson.est","DNA polymerase inhibitor",-0.42939,-1.23,0.214,526,0.425,"trifluridine, menadione, cidofovir, foscarnet, cephalomannine, idoxuridine",0.669586226650809,0.371611069949688,FALSE +"H358","Pearson.est","DNA synthesis inhibitor",-0.30809,-0.872,0.603,939,0.763,"azodicarbonamide, artemisinin, artesunate, cisplatin, capecitabine",0.219682687859849,0.11747546204512,FALSE +"H358","Pearson.est","dopamine receptor antagonist",-0.46175,-1.34,0.15,1179,0.394,"ziprasidone, oxiperomide, amisulpride, domperidone",0.823908740944319,0.404503778174426,FALSE +"H358","Pearson.est","estrogen receptor agonist",0.49608,1.32,0.153,530,0.45,"estradiol, equol, PPT, estrone",0.815308569182401,0.346787486224656,FALSE +"H358","Pearson.est","FGFR inhibitor",-0.24528,-0.677,0.857,983,0.888,"PD.173074, dovitinib, AZD4547",0.0670191780768018,0.051587034221399,FALSE +"H358","Pearson.est","FLT3 inhibitor",0.52278,1.38,0.128,358,0.476,"lestaurtinib, GTP.14564, TG.02, quizartinib, ENMD.2076, tyrphostin.AG.1296, midostaurin, KW.2449, tozasertib, pacritinib, sunitinib",0.892790030352132,0.322393047279507,FALSE +"H358","Pearson.est","glucocorticoid receptor agonist",-0.38682,-1.07,0.363,959,0.53,"triamcinolone, fluocinolone.acetonide, prednisolone.hemisuccinate, desonide, deflazacort, fludroxycortide",0.440093374963888,0.275724130399211,FALSE +"H358","Pearson.est","glutamate receptor antagonist",-0.47351,-1.36,0.139,1084,0.462,"CPP, SIB.1757, kynurenic.acid, JNJ.16259685, felbamate",0.856985199745905,0.335358024443874,FALSE +"H358","Pearson.est","glycogen synthase kinase inhibitor",0.59237,1.58,0.0655,444,0.582,"kenpaullone, LY2090314, CHIR.98014, CHIR.99021, AZD2858, GSK.3.inhibitor.IX",1.18375870000822,0.235077015350112,FALSE +"H358","Pearson.est","growth factor receptor inhibitor",0.40266,1.07,0.371,63,0.61,"lestaurtinib, danusertib",0.430626090384954,0.214670164989233,FALSE +"H358","Pearson.est","HDAC inhibitor",0.51166,1.35,0.154,295,0.459,"M.344, dacinostat, chidamide, entinostat, SB.939, romidepsin, PCI.24781, givinostat, scriptaid, AR.42, ACY.1215",0.812479279163537,0.338187314462739,FALSE +"H358","Pearson.est","histamine receptor antagonist",0.19531,0.521,0.964,5,0.97,"ICI.162846",0.0159229660971692,0.0132282657337552,FALSE +"H358","Pearson.est","HSP inhibitor",0.42928,1.11,0.326,164,0.59,"XL888, PU.H71, NMS.E973, alvespimycin, SNX.5422",0.486782399932061,0.229147988357856,FALSE +"H358","Pearson.est","JAK inhibitor",0.41605,1.1,0.323,371,0.582,"lestaurtinib, PRT062070, TG.02, TG.101209, tozasertib, pacritinib, WHI.P154, AT.9283",0.490797477668897,0.235077015350112,FALSE +"H358","Pearson.est","KIT inhibitor",0.30449,0.804,0.677,358,0.802,"OSI.930, KI.8751, pazopanib, midostaurin, imatinib, telatinib, sunitinib",0.169411331314856,0.0958256317158365,FALSE +"H358","Pearson.est","MEK inhibitor",-0.5586,-1.61,0.0556,932,0.38,"PD.0325901, PD.98059, selumetinib, Ro.4987655, AZD8330, PD.318088, TAK.733, PD.198306, trametinib, PD.184352, cobimetinib, AS.703026",1.25492520841794,0.42021640338319,FALSE +"H358","Pearson.est","MET inhibitor",-0.42221,-1.22,0.231,886,0.379,"PHA.665752, INC.280, PF.04217903, NVP.BVU972",0.636388020107856,0.421360790031928,FALSE +"H358","Pearson.est","microtubule inhibitor",0.36726,0.972,0.475,153,0.684,"cabazitaxel, D.64131",0.323306390375133,0.164943898279884,FALSE +"H358","Pearson.est","mTOR inhibitor",0.49742,1.31,0.15,340,0.414,"WAY.600, PF.05212384, torin.2, ku.0063794, XL388, OSI.027, torin.1, WYE.125132, AZD8055, PF.04691502, deforolimus, PKI.179, WYE.354, sirolimus, MLN0128",0.823908740944319,0.382999658879101,FALSE +"H358","Pearson.est","NFkB pathway inhibitor",0.5574,1.45,0.0895,321,0.535,"parthenolide, EVP4593, curcumin, betulinic.acid, bindarit, BAY.11.7085",1.04817696468409,0.271646217978772,FALSE +"H358","Pearson.est","opioid receptor agonist",-0.50326,-1.47,0.113,828,0.505,"BW.180C, ADL5859, trimebutine, salvinorin.a",0.94692155651658,0.296708621881339,FALSE +"H358","Pearson.est","p38 MAPK inhibitor",-0.47794,-1.34,0.157,1020,0.394,"TAK.715, SB.242235",0.804100347590766,0.404503778174426,FALSE +"H358","Pearson.est","PARP inhibitor",0.52978,1.4,0.109,382,0.479,"PJ.34, talazoparib, olaparib, niraparib",0.962573502059376,0.319664486585437,FALSE +"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.24139,0.649,0.881,358,0.898,"axitinib, KI.8751, crenolanib, pazopanib, CP.673451, imatinib, telatinib, sunitinib",0.0550240915879521,0.0467236633326956,FALSE +"H358","Pearson.est","phosphatase inhibitor",0.55321,1.51,0.0744,402,0.656,"CID.5458317, sodium.stibogluconate, BVT.948, alexidine",1.12842706445412,0.18309616062434,FALSE +"H358","Pearson.est","phosphodiesterase inhibitor",-0.42031,-1.22,0.232,955,0.379,"EMD.53998, trequinsin, avanafil, enoximone",0.6345120151091,0.421360790031928,FALSE +"H358","Pearson.est","PI3K inhibitor",0.3225,0.855,0.61,486,0.766,"PIK.75, PF.05212384, CUDC.907, PF.04691502, PKI.179, CH5132799, PI3K.IN.2, NVP.BEZ235, AZD6482, BGT226, PI.103, YM.201636, TG.100713, ZSTK.474",0.214670164989233,0.115771230367396,FALSE +"H358","Pearson.est","PLK inhibitor",0.32735,0.863,0.613,830,0.799,"rigosertib, volasertib, HMN.214, BI.2536, GSK461364, GW.843682X",0.212539525481585,0.0974532206860086,FALSE +"H358","Pearson.est","progesterone receptor agonist",0.385,1.03,0.42,173,0.633,"melengestrol.acetate, dienogest",0.3767507096021,0.198596289982645,FALSE +"H358","Pearson.est","proteasome inhibitor",0.50376,1.31,0.192,317,0.414,"MG.132, oprozomib, ONX.0914, delanzomib",0.71669877129645,0.382999658879101,FALSE +"H358","Pearson.est","protein synthesis inhibitor",0.4845,1.29,0.19,323,0.399,"florfenicol, thiostrepton, methacycline, tedizolid.phosphate, mercaptopurine, anguidine, harringtonine, cycloheximide, homoharringtonine",0.721246399047171,0.399027104313252,FALSE +"H358","Pearson.est","protein tyrosine kinase inhibitor",0.57945,1.58,0.0524,362,0.582,"BMS.599626, PP.121, tyrphostin.A9, AV.412",1.28066871301627,0.235077015350112,FALSE +"H358","Pearson.est","RAF inhibitor",0.27149,0.723,0.772,276,0.855,"SB.590885, CEP.32496, RAF265",0.112382699664264,0.0680338852718274,FALSE +"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.27837,-0.799,0.674,341,0.781,"cabozantinib, sunitinib, regorafenib, apatinib, sorafenib, vandetanib",0.17134010346468,0.1073489661227,FALSE +"H358","Pearson.est","retinoid receptor agonist",0.63918,1.7,0.0271,448,0.585,"CD.437, tamibarotene, adapalene, LE.135, bexarotene, fenretinide",1.56703070912559,0.23284413391782,FALSE +"H358","Pearson.est","ribonucleotide reductase inhibitor",0.32452,0.868,0.599,303,0.815,"triapine, clofarabine, fludarabine.phosphate, LY2334737",0.222573177610689,0.0888423912600234,FALSE +"H358","Pearson.est","serotonin receptor antagonist",-0.21244,-0.619,0.918,906,0.914,"SB.216641, lurasidone, SB.200646, ziprasidone",0.0371573187987575,0.0390538042661686,FALSE +"H358","Pearson.est","sodium channel blocker",-0.26149,-0.733,0.762,1115,0.849,"butamben, oxcarbazepine",0.1180450286604,0.0710923097560473,FALSE +"H358","Pearson.est","src inhibitor",-0.35145,-1.02,0.399,891,0.55,"ZM.306416, masitinib, dasatinib, saracatinib",0.399027104313252,0.259637310505756,FALSE +"H358","Pearson.est","TGF beta receptor inhibitor",-0.45111,-1.3,0.168,857,0.372,"SB.525334, repsox, SB.431542, D.4476, LY2109761",0.774690718274137,0.429457060118102,FALSE +"H358","Pearson.est","thymidylate synthase inhibitor",-0.47438,-1.3,0.158,1131,0.372,"carmofur, capecitabine",0.801342913045577,0.429457060118102,FALSE +"H358","Pearson.est","topoisomerase inhibitor",0.54248,1.45,0.13,386,0.535,"doxorubicin, exatecan.mesylate, voreloxin, nemorubicin, irinotecan, genz.644282, valrubicin, etoposide, beta.lapachone, etoposide.phosphate, teniposide, topotecan",0.886056647693163,0.271646217978772,FALSE +"H358","Pearson.est","tubulin polymerization inhibitor",0.52489,1.41,0.117,208,0.506,"taltobulin, albendazole, parbendazole, KX2.391, vinorelbine, combretastatin.A.4, paclitaxel, docetaxel",0.931814138253838,0.295849483160201,FALSE +"H358","Pearson.est","tyrosine kinase inhibitor",0.43693,1.18,0.274,362,0.522,"UNC2250, BMS.599626, GTP.14564, PP.121, tyrphostin.A9, aminopurvalanol.a, tivantinib, cabozantinib, sunitinib, AV.412",0.562249437179612,0.282329496997738,FALSE +"H358","Pearson.est","VEGFR inhibitor",0.25216,0.68,0.846,358,0.886,"OSI.930, axitinib, KI.8751, lucitanib, ENMD.2076, AEE788, pazopanib, RAF265, semaxanib, telatinib, cabozantinib, sunitinib",0.0726296369609765,0.0525662781129492,FALSE +"A549","Pearson.est","EGFR inhibitor",0.61182,1.79,0.0328,332,0.407,"erlotinib, vandetanib, pelitinib, gefitinib, GW.583340, afatinib, canertinib, PD.168393, icotinib, XL.647, poziotinib, neratinib, lapatinib, BMS.690514, osimertinib, BMS.599626, dacomitinib, TAK.285, AZD8931, CNX.2006, BIBX.1382, AST.1306, WZ8040, rociletinib, CP.724714, OSI.420, tyrphostin.AG.1478, BIBU.1361, brigatinib, WZ.3146",1.48412615628832,0.39040559077478,FALSE +"A549","Pearson.est","Abl kinase inhibitor",0.43276,1.26,0.217,199,0.707,"ZM.306416, bosutinib, dasatinib, GZD824, ponatinib",0.66354026615147,0.150580586203101,FALSE +"A549","Pearson.est","acetylcholine receptor agonist",-0.46893,-1.31,0.182,1076,0.552,"pilocarpine, nefiracetam, oxiracetam, nicotine",0.739928612014925,0.258060922270801,FALSE +"A549","Pearson.est","acetylcholine receptor antagonist",-0.59188,-1.64,0.0475,970,0.346,"diphemanil, darifenacin, dicycloverine, iododexetimide",1.32330639037513,0.460923901207223,FALSE +"A549","Pearson.est","adenosine receptor antagonist",0.32125,0.926,0.507,294,0.895,"CGS.15943, SCH.58261",0.294992040666664,0.048176964684088,FALSE +"A549","Pearson.est","adrenergic receptor agonist",-0.32274,-0.925,0.531,1138,0.805,"ritodrine, epinephrine, isoxsuprine, isoetharine, xylazine, methyldopa",0.274905478918531,0.0942041196321315,FALSE +"A549","Pearson.est","adrenergic receptor antagonist",-0.17849,-0.515,0.982,798,0.998,"naftidrofuryl, practolol, atenolol...., pindolol, oxprenolol, metoprolol, vincamine, idazoxan, levobunolol",0.00788851221305034,0.000869458712628891,FALSE +"A549","Pearson.est","AKT inhibitor",0.28799,0.804,0.669,516,0.875,"ONC201, CCT128930, AT7867, uprosertib, GSK2110183, GDC.0068",0.174573882232177,0.0579919469776868,FALSE +"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.49903,1.44,0.108,363,0.567,"AP26113, CEP.37440, crizotinib, NVP.TAE684, brigatinib, AZD3463, DMH1",0.96657624451305,0.246416941107093,FALSE +"A549","Pearson.est","androgen receptor antagonist",-0.36129,-1.03,0.4,949,0.805,"bicalutamide, flutamide, nilutamide",0.397940008672038,0.0942041196321315,FALSE +"A549","Pearson.est","AP inhibitor",-0.6771,-1.97,0.00753,1019,0.0907,"LCL.161, idronoxil, GDC.0152, tanshinone.i, embelin",2.1232050237993,1.0423927129399,TRUE +"A549","Pearson.est","ATPase inhibitor",-0.51397,-1.45,0.114,1064,0.472,"omeprazole, digoxin, rabeprazole, ouabain, blebbistatin...., digitoxigenin, digitoxin",0.943095148663527,0.326058001365912,FALSE +"A549","Pearson.est","Aurora kinase inhibitor",0.42892,1.25,0.2,414,0.633,"AMG900, CCT129202, hesperadin, GSK1070916, alisertib, barasertib.HQPA, PHA.680632, danusertib, CCT137690, TAK.901, tozasertib, ENMD.2076, SNS.314, CYC116",0.698970004336019,0.198596289982645,FALSE +"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.44521,-1.26,0.204,1289,0.593,"tilmicosin, azithromycin, dirithromycin",0.690369832574101,0.226945306635737,FALSE +"A549","Pearson.est","bacterial DNA gyrase inhibitor",-0.32131,-0.908,0.539,1136,0.768,"trovafloxacin, sarafloxacin, lomefloxacin",0.268411234813261,0.114638779968488,FALSE +"A549","Pearson.est","BCL inhibitor",0.22454,0.641,0.892,287,0.939,"venetoclax, obatoclax",0.0496351456238769,0.0273344077338891,FALSE +"A549","Pearson.est","Bcr.Abl kinase inhibitor",0.44096,1.28,0.202,308,0.717,"bosutinib, dasatinib, GZD824, ponatinib, tozasertib",0.694648630553376,0.1444808443322,FALSE +"A549","Pearson.est","benzodiazepine receptor agonist",-0.32882,-0.922,0.522,753,0.775,"ivermectin, CL.218872, zaleplon, lorazepam, temazepam, indiplon, bentazepam, nefiracetam, ZK.93423, CGS.20625",0.282329496997738,0.11069829749369,FALSE +"A549","Pearson.est","bromodomain inhibitor",0.42601,1.25,0.21,370,0.633,"JQ1...., OTX015, I.BET.762, I.BET151",0.677780705266081,0.198596289982645,FALSE +"A549","Pearson.est","calcium channel blocker",-0.26868,-0.762,0.69,1298,0.886,"cinnarazine, pranidipine",0.161150909262745,0.0525662781129492,FALSE +"A549","Pearson.est","CC chemokine receptor antagonist",0.52559,1.52,0.0809,36,0.64,"SB.225002, ZK811752",1.09205147838773,0.193820026016113,FALSE +"A549","Pearson.est","CDK inhibitor",0.34615,0.983,0.46,320,0.881,"palbociclib, AT.7519, indisulam, aminopurvalanol.a, abemaciclib, alvocidib, PHA.848125, PHA.793887, ribociclib",0.337242168318426,0.0550240915879521,FALSE +"A549","Pearson.est","CHK inhibitor",-0.8002,-2.28,0,1161,0.0221,"CHIR.124, AZD7762, SB.218078, PF.477736, LY2606368, SCH.900776",Inf,1.65560772631489,TRUE +"A549","Pearson.est","cyclooxygenase inhibitor",-0.32578,-0.935,0.518,1302,0.823,"tepoxalin, amfenac, metoxibutropate, ketoprofen, AM.404",0.285670240254767,0.0846001647877302,FALSE +"A549","Pearson.est","cytochrome P450 inhibitor",0.3982,1.16,0.258,496,0.733,"cobicistat, morin, eplerenone, PF.4981517",0.58838029403677,0.134896025358872,FALSE +"A549","Pearson.est","DNA alkylating agent",-0.29449,-0.837,0.6,1115,0.86,"cisplatin, dianhydrogalactitol, carboplatin, ifosfamide, temozolomide, cyclophosphamide",0.221848749616356,0.0655015487564323,FALSE +"A549","Pearson.est","DNA inhibitor",-0.46055,-1.31,0.18,1156,0.552,"chlorambucil, carboplatin, tirapazamine, teroxirone, busulfan, metronidazole, pibenzimol",0.744727494896694,0.258060922270801,FALSE +"A549","Pearson.est","DNA methyltransferase inhibitor",0.35624,1.04,0.361,125,0.871,"azacitidine, fdcyd",0.442492798094342,0.0599818449923368,FALSE +"A549","Pearson.est","DNA polymerase inhibitor",0.31349,0.92,0.53,447,0.874,"adefovir.dipivoxil, cephalomannine, trifluridine, cidofovir, menadione",0.275724130399211,0.058488567365597,FALSE +"A549","Pearson.est","DNA synthesis inhibitor",-0.36211,-1.02,0.423,1243,0.781,"CB.10.277, artemisinin, azodicarbonamide, nelarabine",0.373659632624958,0.1073489661227,FALSE +"A549","Pearson.est","dopamine receptor antagonist",0.25905,0.756,0.714,339,0.881,"remoxipride, piperacetazine, ziprasidone, oxiperomide, clebopride, domperidone",0.146301788223826,0.0550240915879521,FALSE +"A549","Pearson.est","estrogen receptor agonist",0.2094,0.598,0.903,1118,0.939,"erteberel, levonorgestrel, equol, estradiol.cypionate, ethinyl.estradiol, PPT, estradiol, estrone",0.0443122496864942,0.0273344077338891,FALSE +"A549","Pearson.est","FGFR inhibitor",-0.22505,-0.641,0.87,1061,0.991,"MK.2461, lucitanib, orantinib",0.0604807473813815,0.00392634551472468,FALSE +"A549","Pearson.est","FLT3 inhibitor",-0.22547,-0.64,0.872,1067,0.96,"tandutinib, KW.2449, gilteritinib, lestaurtinib, sunitinib",0.0594835150674328,0.0177287669604316,FALSE +"A549","Pearson.est","glucocorticoid receptor agonist",0.4962,1.39,0.134,456,0.546,"ciclesonide, clobetasol.propionate, methylprednisolone, triamcinolone.acetonide, halobetasol.propionate, deflazacort, prednisolone.hemisuccinate, betamethasone, fludroxycortide, beclomethasone.dipropionate, prednisolone.acetate, flumethasone, triamcinolone, flumethasone.pivalate, dexamethasone.acetate, rimexolone",0.872895201635192,0.262807357295263,FALSE +"A549","Pearson.est","glutamate receptor antagonist",0.26345,0.767,0.701,444,0.888,"CPP, SIB.1757, MTPG, diazooxonorleucine, felbamate, latrepirdine",0.154281982033341,0.051587034221399,FALSE +"A549","Pearson.est","glycogen synthase kinase inhibitor",0.23664,0.7,0.813,1080,0.936,"TWS.119, CHIR.99021, tideglusib, AZD2858, LY2090314, kenpaullone, CHIR.98014, GSK.3.inhibitor.IX, indirubin",0.0899094544059319,0.0287241512618947,FALSE +"A549","Pearson.est","growth factor receptor inhibitor",0.52532,1.51,0.0921,347,0.57,"GSK1904529A, GSK1838705A, danusertib, PHA.848125, AZD3463",1.03574036980315,0.244125144327509,FALSE +"A549","Pearson.est","HDAC inhibitor",0.26512,0.769,0.752,519,0.909,"belinostat, panobinostat, pyroxamide, resminostat, JNJ.26481585, scriptaid, givinostat, AR.42, entinostat, NSC.3852, vorinostat, nexturastat.a, trichostatin.a, R306465, PCI.24781",0.123782159408358,0.0414361167780325,FALSE +"A549","Pearson.est","histamine receptor antagonist",-0.32675,-0.945,0.503,1092,0.845,"nizatidine, epinastine, cyproheptadine, famotidine, ICI.162846, lafutidine, tecastemizole",0.298432014944073,0.0731432910503077,FALSE +"A549","Pearson.est","HMGCR inhibitor",-0.79618,-2.24,0,1165,0.0176,"mevastatin, atorvastatin, simvastatin, fluvastatin, pitavastatin",Inf,1.75448733218585,TRUE +"A549","Pearson.est","HSP inhibitor",-0.18372,-0.523,0.965,954,1,"guanidine, XL888, SNX.2112, NMS.E973",0.0154726866562074,0,FALSE +"A549","Pearson.est","JAK inhibitor",0.21633,0.633,0.864,333,0.925,"atiprimod, ruxolitinib, pacritinib, tozasertib, WHI.P154, filgotinib",0.0634862575211067,0.0338582672609674,FALSE +"A549","Pearson.est","KIT inhibitor",0.28792,0.82,0.641,315,0.873,"dasatinib, lenvatinib, vatalanib, midostaurin, motesanib, regorafenib",0.193141970481183,0.0589857562944303,FALSE +"A549","Pearson.est","MDM inhibitor",-0.62931,-1.79,0.0164,1219,0.203,"AMG.232, CGM097, serdemetan",1.7851561519523,0.692503962086787,TRUE +"A549","Pearson.est","MEK inhibitor",0.55728,1.61,0.0589,281,0.543,"selumetinib, AZD8330, cobimetinib, AS.703026, refametinib, Ro.4987655, trametinib, PD.0325901, TAK.733, PD.318088, arctigenin, U.0126",1.2298847052129,0.265200170411153,FALSE +"A549","Pearson.est","MET inhibitor",0.36574,1.06,0.374,383,0.869,"NVP.BVU972, PHA.665752, LY2801653",0.42712839779952,0.0609802235513335,FALSE +"A549","Pearson.est","microtubule inhibitor",0.24048,0.68,0.83,30,0.938,"triclabendazole",0.0809219076239261,0.0277971616209356,FALSE +"A549","Pearson.est","mTOR inhibitor",-0.34671,-0.986,0.468,952,0.807,"palomid.529, MLN0128, deforolimus, PP242, OSI.027, torin.1, WYE.125132, torin.2, sirolimus, LY3023414, ku.0063794",0.329754146925876,0.0931264652779296,FALSE +"A549","Pearson.est","NFkB pathway inhibitor",0.29381,0.839,0.638,266,0.919,"tyloxapol, IKK.2.inhibitor.V, bortezomib, bindarit",0.195179321278838,0.0366844886138887,FALSE +"A549","Pearson.est","opioid receptor agonist",-0.27715,-0.769,0.72,1150,0.906,"ADL5859, BW.180C",0.142667503568732,0.0428718023231869,FALSE +"A549","Pearson.est","p38 MAPK inhibitor",-0.26811,-0.761,0.727,1215,0.857,"SB.242235, skepinone.l",0.138465589140962,0.0670191780768018,FALSE +"A549","Pearson.est","PARP inhibitor",-0.39874,-1.14,0.295,1348,0.725,"PJ.34, AG.14361",0.530177984021837,0.139661993429006,FALSE +"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.28728,0.832,0.627,315,0.903,"axitinib, dasatinib, lenvatinib, linifanib, ponatinib, vatalanib, motesanib, regorafenib",0.202732459169284,0.0443122496864942,FALSE +"A549","Pearson.est","phosphatase inhibitor",-0.28111,-0.795,0.694,1157,0.898,"CID.5458317, BVT.948, bis.maltolato.oxovanadium.IV.",0.158640529545145,0.0467236633326956,FALSE +"A549","Pearson.est","phosphodiesterase inhibitor",0.30735,0.869,0.603,151,0.95,"cilostamide, papaverine",0.219682687859849,0.0222763947111523,FALSE +"A549","Pearson.est","PI3K inhibitor",0.1686,0.497,0.98,215,0.977,"PI.828, alpelisib, CH5132799, TG.100713",0.00877392430750515,0.0101054362812269,FALSE +"A549","Pearson.est","PLK inhibitor",0.63238,1.8,0.0234,413,0.58,"GSK461364, volasertib, NMS.1286937, BI.2536",1.63078414258986,0.236572006437063,FALSE +"A549","Pearson.est","potassium channel blocker",-0.5156,-1.48,0.0689,1027,0.481,"mepivacaine, ibutilide, meglitinide, dofetilide",1.16178077809237,0.317854923626168,FALSE +"A549","Pearson.est","PPAR receptor agonist",0.34588,1.03,0.392,439,0.851,"ciprofibrate, oleoylethanolamide, clofibrate",0.406713932979543,0.0700704399154121,FALSE +"A549","Pearson.est","progesterone receptor agonist",-0.52624,-1.54,0.0705,1125,0.445,"norethindrone.acetate, melengestrol.acetate, norgestrel, danazol",1.1518108830086,0.351639989019068,FALSE +"A549","Pearson.est","proteasome inhibitor",0.33333,0.971,0.498,944,0.869,"bortezomib, ONX.0914, carfilzomib, oprozomib, delanzomib, MG.132, ixazomib.citrate, ixazomib",0.302770657240282,0.0609802235513335,FALSE +"A549","Pearson.est","protein synthesis inhibitor",-0.39897,-1.13,0.304,1105,0.695,"cycloheximide, thiostrepton, bruceantin, chloramphenicol.palmitate, mercaptopurine, azomycin..2.nitroimidazole.",0.517126416391246,0.158015195409886,FALSE +"A549","Pearson.est","protein tyrosine kinase inhibitor",0.42096,1.22,0.213,271,0.652,"NVP.TAE226, BMS.599626, mubritinib, CP.724714",0.671620396561262,0.18575240426808,FALSE +"A549","Pearson.est","RAF inhibitor",0.30033,0.867,0.592,315,0.89,"CEP.32496, TAK.632, AZ.628, regorafenib",0.22767829327708,0.0506099933550872,FALSE +"A549","Pearson.est","RET tyrosine kinase inhibitor",-0.44491,-1.25,0.209,1350,0.565,"apatinib, sunitinib",0.679853713888946,0.247951552180562,FALSE +"A549","Pearson.est","retinoid receptor agonist",0.68364,1.97,0.0207,279,0.425,"CD.437, bexarotene, tamibarotene, fenretinide, AM.580, adapalene",1.68402965454308,0.371611069949688,FALSE +"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.36866,-1.05,0.383,1323,0.812,"pentostatin, cytarabine",0.416801226031377,0.0904439707588247,FALSE +"A549","Pearson.est","serotonin receptor antagonist",-0.14297,-0.395,0.996,841,0.997,"sertindole, lurasidone, RS.16566, tropisetron, SB.200646",0.00174066157630127,0.00130484168834428,FALSE +"A549","Pearson.est","sodium channel blocker",0.30685,0.867,0.599,157,0.89,"brivaracetam, ajmaline, benzethonium",0.222573177610689,0.0506099933550872,FALSE +"A549","Pearson.est","src inhibitor",0.48787,1.39,0.14,136,0.546,"saracatinib, ZM.306416, bosutinib, dasatinib",0.853871964321762,0.262807357295263,FALSE +"A549","Pearson.est","sterol demethylase inhibitor",0.29425,0.825,0.633,263,0.89,"sulconazole, chlormidazole",0.198596289982645,0.0506099933550872,FALSE +"A549","Pearson.est","TGF beta receptor inhibitor",-0.48438,-1.37,0.151,1137,0.555,"LY2109761, adaprev, D.4476",0.821023052706831,0.255707016877324,FALSE +"A549","Pearson.est","thymidylate synthase inhibitor",0.51961,1.47,0.11,415,0.568,"carmofur, raltitrexed, capecitabine, trifluridine, doxifluridine",0.958607314841775,0.245651664288981,FALSE +"A549","Pearson.est","topoisomerase inhibitor",0.23069,0.671,0.844,62,0.927,"dexrazoxane, daunorubicin, epirubicin",0.073657553374345,0.0329202658555029,FALSE +"A549","Pearson.est","tubulin polymerization inhibitor",0.35216,0.997,0.422,328,0.887,"mebendazole, albendazole, paclitaxel, indibulin, epothilone.b, docetaxel, plinabulin, parbendazole, vincristine",0.374687549038326,0.0520763801682736,FALSE +"A549","Pearson.est","tyrosine kinase inhibitor",0.39875,1.15,0.279,315,0.711,"NVP.TAE226, vandetanib, tyrphostin.AG.99, BMS.599626, dasatinib, aminopurvalanol.a, mubritinib, tivantinib, AMG.208, CP.724714, regorafenib",0.554395796726402,0.148130399270234,FALSE +"A549","Pearson.est","VEGFR inhibitor",0.32981,0.963,0.489,432,0.85,"vandetanib, tivozanib, ZM.306416, XL.647, axitinib, BMS.690514, golvatinib, lenvatinib, linifanib, vatalanib, motesanib, regorafenib, ENMD.2076, semaxanib, cediranib, AEE788, PD.173074",0.31069114087638,0.0705810742857073,FALSE +"A549","Pearson.est","vitamin D receptor agonist",0.58106,1.66,0.0593,351,0.557,"calcitriol, alfacalcidol, tacalcitol, paricalcitol, maxacalcitol",1.22694530663574,0.254144804826271,FALSE +"HCC15","Pearson.est","EGFR inhibitor",-0.20418,-0.594,0.922,1291,0.928,"PD.168393, XL.647, tyrphostin.AG.1478, gefitinib, vandetanib, ARRY.334543",0.0352690789463706,0.0324520237811379,FALSE +"HCC15","Pearson.est","Abl kinase inhibitor",0.26327,0.706,0.824,226,0.976,"bafetinib, KW.2449, tozasertib",0.0840727883028842,0.0105501823333082,FALSE +"HCC15","Pearson.est","acetylcholine receptor antagonist",0.40581,1.09,0.356,635,0.633,"methscopolamine, darifenacin, dicycloverine, hyoscyamine",0.448550002027125,0.198596289982645,FALSE +"HCC15","Pearson.est","adenosine receptor antagonist",-0.4358,-1.25,0.223,1108,0.51,"CGS.15943, theophylline, sulmazole",0.651695136951839,0.292429823902064,FALSE +"HCC15","Pearson.est","adrenergic receptor agonist",0.23336,0.608,0.904,116,0.966,"buphenine, metaraminol",0.0438315695246367,0.0150228735845067,FALSE +"HCC15","Pearson.est","adrenergic receptor antagonist",-0.35669,-1.02,0.409,1253,0.669,"idazoxan, imiloxan, naftidrofuryl, atenolol...., practolol, carvedilol",0.388276691992658,0.174573882232177,FALSE +"HCC15","Pearson.est","AKT inhibitor",0.60668,1.59,0.0349,194,0.34,"MK.2206, A.674563, triciribine, GSK2110183, AZD5363, GDC.0068",1.45717457304082,0.468521082957745,FALSE +"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.38019,0.999,0.454,441,0.759,"CEP.37440, AP26113, AZD3463, NVP.TAE684",0.342944147142896,0.11975822410452,FALSE +"HCC15","Pearson.est","androgen receptor antagonist",-0.67353,-1.92,0.0106,949,0.38,"enzalutamide, cyproterone.acetate, RU.58841, bicalutamide, flutamide, nilutamide",1.97469413473523,0.42021640338319,FALSE +"HCC15","Pearson.est","antioxidant",-0.23419,-0.664,0.846,1285,0.936,"benfotiamine",0.0726296369609765,0.0287241512618947,FALSE +"HCC15","Pearson.est","AP inhibitor",0.60547,1.61,0.0487,545,0.347,"birinapant, idronoxil, tanshinone.i, LCL.161, GDC.0152",1.31247103878537,0.459670525209126,FALSE +"HCC15","Pearson.est","ATPase inhibitor",0.43873,1.18,0.264,329,0.582,"thonzonium, oligomycin.a, ouabain, evodiamine, omeprazole, digoxin",0.578396073130169,0.235077015350112,FALSE +"HCC15","Pearson.est","Aurora kinase inhibitor",0.67754,1.79,0.0142,360,0.195,"TAK.901, PHA.680632, hesperadin, AT.9283, barasertib, ZM.447439, danusertib, GSK1070916, barasertib.HQPA, CCT129202, KW.2449, tozasertib, SNS.314, AMG900, PF.03814735, alisertib, aurora.a.inhibitor.i, MK.8745, CYC116",1.84771165561694,0.709965388637482,TRUE +"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.26865,0.712,0.783,259,1,"tedizolid, radezolid",0.106238237942057,0,FALSE +"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",-0.48903,-1.43,0.111,1371,0.564,"finafloxacin, nadifloxacin",0.954677021213343,0.248720896016658,FALSE +"HCC15","Pearson.est","BCL inhibitor",0.63651,1.69,0.0324,172,0.3,"ABT.737, navitoclax, obatoclax, TW.37",1.48945498979339,0.522878745280338,FALSE +"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",-0.28125,-0.837,0.624,1247,0.794,"bosutinib, imatinib, dasatinib",0.204815410317576,0.100179497572904,FALSE +"HCC15","Pearson.est","benzodiazepine receptor agonist",-0.4481,-1.29,0.178,1328,0.504,"gamma.aminobutyric.acid, bentazepam, zaleplon",0.749579997691106,0.297569463554475,FALSE +"HCC15","Pearson.est","bromodomain inhibitor",0.69007,1.84,0.0137,375,0.185,"JQ1...., bromosporine, PFI.1, OTX015",1.86327943284359,0.732828271596986,TRUE +"HCC15","Pearson.est","calcium channel blocker",0.284,0.766,0.731,372,0.952,"mibefradil, SKF.96365, carboxyamidotriazole, tetrandrine",0.13608262304214,0.0213630516155257,FALSE +"HCC15","Pearson.est","CC chemokine receptor antagonist",0.29988,0.798,0.685,471,0.97,"navarixin, SB.225002, UNBS.5162, ZK811752",0.164309428507574,0.0132282657337552,FALSE +"HCC15","Pearson.est","CDK inhibitor",0.51321,1.38,0.14,476,0.42,"BMS.387032, dinaciclib, JNJ.7706621, indisulam, TG.02, kenpaullone, NU6027, AZD5438, AT.7519, palbociclib, BMS.265246, R547, abemaciclib, ribociclib",0.853871964321762,0.3767507096021,FALSE +"HCC15","Pearson.est","CHK inhibitor",0.23489,0.624,0.896,607,0.971,"SB.218078, CHIR.124, AZD7762, SCH.900776",0.0476919903378748,0.0127807700919951,FALSE +"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.22217,-0.645,0.895,1156,0.919,"phenylbutazone, tryptanthrin, acetylsalicylsalicylic.acid, aspirin, metoxibutropate, phenazone",0.048176964684088,0.0366844886138887,FALSE +"HCC15","Pearson.est","cytochrome P450 inhibitor",-0.60937,-1.73,0.0386,884,0.322,"morin, PF.4981517, clotrimazole, eplerenone, metyrapone",1.41341269532825,0.492144128304169,FALSE +"HCC15","Pearson.est","DNA alkylating agent",0.26352,0.692,0.828,416,0.974,"carmustine, melphalan, dianhydrogalactitol, mitomycin.c, estramustine, TH.302",0.0819696632151199,0.0114410431213845,FALSE +"HCC15","Pearson.est","DNA inhibitor",0.44101,1.17,0.272,303,0.578,"chlorambucil, oxaliplatin, carmustine, melphalan, valrubicin, mechlorethamine",0.565431095965801,0.238072161579471,FALSE +"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.47532,1.25,0.212,450,0.529,"azacitidine, disulfiram, fdcyd, SGI.1027",0.673664139071249,0.276544327964814,FALSE +"HCC15","Pearson.est","DNA polymerase inhibitor",0.24958,0.66,0.872,18,0.971,"cephalomannine",0.0594835150674328,0.0127807700919951,FALSE +"HCC15","Pearson.est","DNA synthesis inhibitor",0.21621,0.571,0.941,382,0.976,"enocitabine, floxuridine, cyclocytidine, mitomycin.c",0.0264103765727431,0.0105501823333082,FALSE +"HCC15","Pearson.est","dopamine receptor antagonist",-0.44764,-1.29,0.197,1057,0.504,"amisulpride, lurasidone, clebopride, UH.232...., raclopride, piperacetazine, mesoridazine",0.705533773838407,0.297569463554475,FALSE +"HCC15","Pearson.est","estrogen receptor agonist",-0.47744,-1.38,0.127,1319,0.56,"estrone, estradiol.cypionate",0.896196279044043,0.2518119729938,FALSE +"HCC15","Pearson.est","FGFR inhibitor",0.6053,1.62,0.053,378,0.385,"erdafitinib, PD.173074, nintedanib, dovitinib, lucitanib, regorafenib",1.27572413039921,0.414539270491499,FALSE +"HCC15","Pearson.est","FLT3 inhibitor",0.42469,1.11,0.33,511,0.618,"KW.2449, sorafenib, tozasertib, TG.02, TG.101348, quizartinib, dovitinib, pacritinib, ponatinib, lestaurtinib",0.481486060122112,0.209011524911184,FALSE +"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.54318,-1.58,0.0771,1063,0.419,"methylprednisolone, prednisolone.acetate, flumethasone, difluprednate, desonide, flumethasone.pivalate, fluticasone.propionate, beclomethasone.dipropionate, clobetasol.propionate, fluocinolone.acetonide, halcinonide, halobetasol.propionate, ciclesonide, dexamethasone.acetate",1.11294562194904,0.377785977033705,FALSE +"HCC15","Pearson.est","glutamate receptor antagonist",-0.41344,-1.18,0.254,1407,0.576,"tiletamine, MTPG",0.595166283380062,0.239577516576788,FALSE +"HCC15","Pearson.est","glycogen synthase kinase inhibitor",0.53294,1.43,0.105,373,0.392,"CHIR.99021, AZD2858, kenpaullone, LY2090314, TWS.119",0.978810700930062,0.406713932979543,FALSE +"HCC15","Pearson.est","growth factor receptor inhibitor",0.54966,1.46,0.0782,511,0.425,"danusertib, GSK1904529A, AZD3463, GW.441756, lestaurtinib",1.10679324694015,0.371611069949688,FALSE +"HCC15","Pearson.est","HDAC inhibitor",0.45984,1.22,0.22,567,0.533,"PCI.24781, AR.42, givinostat, NSC.3852, tacedinaline, chidamide, entinostat, M.344, scriptaid, RGFP966, pyroxamide, panobinostat, dacinostat, romidepsin, trichostatin.a, JNJ.26481585, SB.939, vorinostat",0.657577319177794,0.273272790973428,FALSE +"HCC15","Pearson.est","histamine receptor antagonist",-0.45702,-1.32,0.173,1056,0.589,"tecastemizole, cyproheptadine, terfenadine, cimetidine, epinastine, famotidine, ICI.162846, zolantidine, ranitidine",0.761953896871205,0.229884705212898,FALSE +"HCC15","Pearson.est","HMGCR inhibitor",0.35433,0.941,0.526,528,0.799,"simvastatin, mevastatin, lovastatin, fluvastatin, atorvastatin",0.279014255846261,0.0974532206860086,FALSE +"HCC15","Pearson.est","HSP inhibitor",0.20521,0.538,0.943,251,0.978,"VER.49009, XL888",0.0254883072626717,0.00966114521239857,FALSE +"HCC15","Pearson.est","JAK inhibitor",0.41664,1.12,0.319,286,0.622,"AT.9283, TG.101209, CEP.33779, tozasertib, TG.02, TG.101348, AZ960",0.496209316942819,0.206209615309181,FALSE +"HCC15","Pearson.est","KIT inhibitor",0.20567,0.529,0.95,418,0.964,"sorafenib, OSI.930, KI.8751, regorafenib, motesanib",0.0222763947111523,0.0159229660971692,FALSE +"HCC15","Pearson.est","MDM inhibitor",0.73989,1.93,0.00458,153,0.131,"nutlin.3, idasanutlin, AMG.232, CGM097",2.33913452199613,0.882728704344236,TRUE +"HCC15","Pearson.est","MEK inhibitor",-0.28163,-0.795,0.705,1179,0.827,"PD.318088, arctigenin, refametinib, Ro.4987655, AS.703026",0.151810883008601,0.0824944904474534,FALSE +"HCC15","Pearson.est","MET inhibitor",0.29708,0.788,0.709,404,0.962,"PF.04217903, PHA.665752",0.149353764816933,0.0168249279621871,FALSE +"HCC15","Pearson.est","microtubule inhibitor",0.49469,1.3,0.18,310,0.512,"vinflunine, cytochalasin.b, D.64131, colchicine, triclabendazole",0.744727494896694,0.290730039024169,FALSE +"HCC15","Pearson.est","mTOR inhibitor",0.26169,0.691,0.83,243,0.954,"XL388, PI.103, WYE.125132, GSK2126458, PF.04691502, OSI.027",0.0809219076239261,0.0204516252959049,FALSE +"HCC15","Pearson.est","NFkB pathway inhibitor",0.42719,1.16,0.276,736,0.574,"parthenolide...., curcumin, EVP4593, BAY.11.7082, Ro.106.9920, bortezomib, IKK.2.inhibitor.V, bindarit",0.559090917934782,0.241088107602027,FALSE +"HCC15","Pearson.est","opioid receptor agonist",0.24706,0.654,0.86,649,0.958,"ADL5859, trimebutine, salvinorin.a, cebranopadol",0.0655015487564323,0.0186344909214556,FALSE +"HCC15","Pearson.est","p38 MAPK inhibitor",0.54367,1.43,0.122,297,0.392,"SB.242235, talmapimod, skepinone.l, SB.239063",0.913640169325252,0.406713932979543,FALSE +"HCC15","Pearson.est","PARP inhibitor",0.58209,1.54,0.0673,596,0.39,"olaparib, talazoparib, niraparib, AG.14361, PJ.34, endo.IWR.1, AZD2461, E7449",1.17198493577602,0.408935392973501,FALSE +"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.26111,0.706,0.82,418,0.976,"sorafenib, nintedanib, KI.8751, dovitinib, SU014813, axitinib, linifanib, regorafenib, motesanib",0.0861861476162833,0.0105501823333082,FALSE +"HCC15","Pearson.est","phosphatase inhibitor",0.33106,0.908,0.559,133,0.813,"sodium.stibogluconate, CID.5458317",0.252588192113577,0.0899094544059319,FALSE +"HCC15","Pearson.est","phosphodiesterase inhibitor",0.47247,1.25,0.216,192,0.529,"cilostamide, papaverine, YM.976",0.665546248849069,0.276544327964814,FALSE +"HCC15","Pearson.est","PI3K inhibitor",0.29144,0.773,0.742,477,0.964,"PI.103, CH5132799, GSK2126458, PF.04691502, buparlisib, taselisib, BGT226, alpelisib, voxtalisib, CUDC.907, ZSTK.474, GDC.0941, PI3K.IN.2",0.129596094720973,0.0159229660971692,FALSE +"HCC15","Pearson.est","PLK inhibitor",-0.31377,-0.914,0.548,1150,0.78,"HMN.214, rigosertib",0.261219441515631,0.10790539730952,FALSE +"HCC15","Pearson.est","potassium channel blocker",-0.34993,-1.02,0.398,1301,0.669,"mepivacaine, oleoylethanolamide",0.400116927926312,0.174573882232177,FALSE +"HCC15","Pearson.est","PPAR receptor agonist",-0.31027,-0.905,0.553,1116,0.753,"ciprofibrate, fenofibrate, oleoylethanolamide",0.257274868695302,0.123205023799299,FALSE +"HCC15","Pearson.est","progesterone receptor agonist",-0.30161,-0.849,0.596,935,0.815,"melengestrol.acetate, dienogest, levonorgestrel, norgestrel, danazol, norethindrone.acetate",0.224753740259764,0.0888423912600234,FALSE +"HCC15","Pearson.est","proteasome inhibitor",0.82848,2.21,0,164,0.00966,"ixazomib.citrate, delanzomib, MG.132, carfilzomib, oprozomib, ixazomib",Inf,2.01502287358451,TRUE +"HCC15","Pearson.est","protein synthesis inhibitor",0.37313,0.997,0.469,498,0.74,"methacycline, florfenicol, harringtonine, bruceantin, anguidine, tedizolid.phosphate, brefeldin.a, homoharringtonine",0.328827157284917,0.130768280269024,FALSE +"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.52595,1.38,0.125,341,0.42,"NVP.TAE226, mubritinib, tyrphostin.A9",0.903089986991944,0.3767507096021,FALSE +"HCC15","Pearson.est","RAF inhibitor",0.50701,1.34,0.149,420,0.464,"TAK.632, CEP.32496, sorafenib, AZ.628, RAF265, regorafenib, LGX818",0.826813731587726,0.333482019445119,FALSE +"HCC15","Pearson.est","RET tyrosine kinase inhibitor",-0.24403,-0.695,0.834,1334,0.939,"vandetanib",0.0788339493622613,0.0273344077338891,FALSE +"HCC15","Pearson.est","retinoid receptor agonist",0.54139,1.43,0.111,532,0.392,"AM.580, tamibarotene, bexarotene, fenretinide, CD.437",0.954677021213343,0.406713932979543,FALSE +"HCC15","Pearson.est","ribonucleotide reductase inhibitor",0.37092,0.999,0.449,603,0.759,"LY2334737, clofarabine, fludarabine, triapine, cladribine, pentostatin, gemcitabine, fludarabine.phosphate",0.347753658996677,0.11975822410452,FALSE +"HCC15","Pearson.est","serotonin receptor antagonist",0.34782,0.918,0.572,513,0.817,"SB.200646, pirenperone, ziprasidone, sertindole, SB.216641, SB.228357",0.242603971206976,0.0877779434675845,FALSE +"HCC15","Pearson.est","sodium channel blocker",-0.34429,-0.99,0.413,1245,0.682,"oxcarbazepine, quinidine, mepivacaine, benzocaine",0.384049948343599,0.166215625343521,FALSE +"HCC15","Pearson.est","src inhibitor",-0.36537,-1.1,0.347,1207,0.619,"saracatinib, bosutinib, PP.2, dasatinib",0.459670525209126,0.208309350979882,FALSE +"HCC15","Pearson.est","sterol demethylase inhibitor",-0.39557,-1.15,0.279,1183,0.579,"posaconazole, terconazole, lanoconazole",0.554395796726402,0.237321436272564,FALSE +"HCC15","Pearson.est","TGF beta receptor inhibitor",-0.64729,-1.88,0.014,1269,0.242,"D.4476, repsox, LY2109761",1.85387196432176,0.616184634019569,TRUE +"HCC15","Pearson.est","thymidylate synthase inhibitor",0.57091,1.52,0.0797,436,0.384,"raltitrexed, carmofur, doxifluridine",1.09854167860389,0.415668775632469,FALSE +"HCC15","Pearson.est","topoisomerase inhibitor",0.56227,1.47,0.0978,411,0.443,"nemorubicin, mitoxantrone, topotecan, genz.644282, TAS.103, amsacrine, etoposide.phosphate, etoposide, epirubicin, idarubicin, voreloxin, valrubicin, doxorubicin, licochalcone.a, daunorubicin, teniposide, dexrazoxane, camptothecin",1.0096611452124,0.35359627377693,FALSE +"HCC15","Pearson.est","tubulin polymerization inhibitor",0.4848,1.29,0.196,405,0.506,"fenbendazole, vincristine, CYT.997, oxibendazole, vinorelbine, mebendazole, nocodazole, KX2.391, albendazole, parbendazole, indibulin, combretastatin.A.4, flubendazole, docetaxel, dolastatin.10, plinabulin, vindesine",0.707743928643524,0.295849483160201,FALSE +"HCC15","Pearson.est","tyrosine kinase inhibitor",0.31361,0.831,0.638,378,0.934,"bafetinib, UNC2250, sorafenib, NVP.TAE226, mubritinib, tyrphostin.A9, regorafenib",0.195179321278838,0.0296531237699066,FALSE +"HCC15","Pearson.est","VEGFR inhibitor",0.46221,1.24,0.24,418,0.523,"foretinib, PD.173074, AEE788, sorafenib, OSI.930, golvatinib, MGCD.265, nintedanib, KI.8751, RAF265, dovitinib, SU014813, lucitanib, axitinib, tivozanib, linifanib, regorafenib, motesanib",0.619788758288394,0.281498311132726,FALSE +"HCC15","Pearson.est","vitamin D receptor agonist",0.37165,0.99,0.453,82,0.731,"ercalcitriol, alfacalcidol",0.343901797987168,0.13608262304214,FALSE +"HCC44","Pearson.est","EGFR inhibitor",-0.12151,-0.378,1,281,0.999,"dovitinib, WZ.4002, PD.153035, AZD8931, poziotinib, tyrphostin.AG.1478, tucatinib, PD.168393, icotinib, osimertinib, erlotinib, CNX.2006, dacomitinib, afatinib, AEE788, brigatinib, WZ8040, pelitinib, BIBX.1382, neratinib, CP.724714, BIBU.1361, ARRY.334543, tyrphostin.AG.494, canertinib, gefitinib, XL.647, lapatinib, rociletinib, OSI.420, salvianolic.acid.B, FERb.033, BMS.690514",0,0.000434511774017692,FALSE +"HCC44","Pearson.est","Abl kinase inhibitor",0.38209,1.04,0.414,333,0.587,"GZD824, KW.2449, tozasertib, bafetinib, flumatinib, ZM.306416",0.382999658879101,0.231361898752386,FALSE +"HCC44","Pearson.est","adrenergic receptor agonist",0.34917,0.974,0.477,22,0.618,"clenbuterol, midodrine",0.321481620959886,0.209011524911184,FALSE +"HCC44","Pearson.est","adrenergic receptor antagonist",0.363,1.03,0.403,445,0.558,"oxprenolol, dronedarone, practolol, naftidrofuryl, vincamine, metoprolol, atipamezole, idazoxan",0.39469495385889,0.253365801062421,FALSE +"HCC44","Pearson.est","AKT inhibitor",-0.31927,-0.973,0.436,821,0.735,"AZD5363, triciribine, GDC.0068, ONC201, GSK2110183",0.360513510731414,0.133712660915805,FALSE +"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.32892,-1.04,0.378,1039,0.82,"DMH1, crizotinib",0.422508200162775,0.0861861476162833,FALSE +"HCC44","Pearson.est","ATPase inhibitor",-0.33154,-0.997,0.415,1064,0.791,"digoxin, digitoxigenin",0.381951903287907,0.101823516502323,FALSE +"HCC44","Pearson.est","Aurora kinase inhibitor",0.52812,1.44,0.0836,411,0.416,"MLN.8054, KW.2449, danusertib, GSK1070916, tozasertib, CCT137690, aurora.a.inhibitor.i, PHA.680632, CCT129202",1.07779372256098,0.380906669373257,FALSE +"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34099,-1.07,0.34,1146,0.911,"azalomycin.b",0.468521082957745,0.0404816230270017,FALSE +"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",0.37504,1.04,0.408,55,0.587,"trovafloxacin",0.38933983691012,0.231361898752386,FALSE +"HCC44","Pearson.est","BCL inhibitor",-0.29326,-0.914,0.535,976,0.762,"navitoclax, oridonin, venetoclax",0.271646217978772,0.1180450286604,FALSE +"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",0.29236,0.831,0.646,325,0.761,"GZD824, tozasertib, bafetinib, flumatinib",0.189767482004916,0.118615343229427,FALSE +"HCC44","Pearson.est","benzodiazepine receptor agonist",-0.31893,-0.978,0.444,369,0.773,"ivermectin, zaleplon, ZK.93423, bentazepam, CGS.20625, indiplon, CL.218872, nefiracetam",0.35261702988538,0.111820506081675,FALSE +"HCC44","Pearson.est","bromodomain inhibitor",-0.54679,-1.72,0.0316,870,0.525,"I.BET.762, bromosporine, JQ1...., OTX015",1.5003129173816,0.279840696594043,FALSE +"HCC44","Pearson.est","calcium channel blocker",-0.34618,-1.09,0.346,861,1,"tetrandrine, mibefradil, pranidipine, penfluridol, SR.33805, fendiline",0.460923901207223,0,FALSE +"HCC44","Pearson.est","CC chemokine receptor antagonist",0.4306,1.18,0.282,531,0.541,"SB.225002, navarixin, MK.0812, ZK811752",0.549750891680639,0.266802734893431,FALSE +"HCC44","Pearson.est","CDK inhibitor",0.39845,1.1,0.345,231,0.653,"aminopurvalanol.a, abemaciclib, PHA.848125, indisulam, ribociclib, PHA.793887, TG.02",0.462180904926726,0.185086818724926,FALSE +"HCC44","Pearson.est","cyclooxygenase inhibitor",0.49714,1.37,0.153,440,0.381,"metoxibutropate, FR.122047, piroxicam, ketoprofen, amfenac, meloxicam, suxibuzone, curcumin, pterostilbene",0.815308569182401,0.419075024324381,FALSE +"HCC44","Pearson.est","DNA alkylating agent",0.23995,0.676,0.859,81,0.922,"mitomycin.c, satraplatin",0.0660068361687577,0.0352690789463706,FALSE +"HCC44","Pearson.est","DNA inhibitor",-0.23632,-0.719,0.795,882,0.825,"busulfan, chlorambucil, bendamustine, teroxirone, mechlorethamine",0.0996328713435297,0.0835460514500749,FALSE +"HCC44","Pearson.est","DNA polymerase inhibitor",-0.34685,-1.06,0.352,1034,0.849,"trifluridine, cidofovir",0.453457336521869,0.0710923097560473,FALSE +"HCC44","Pearson.est","DNA synthesis inhibitor",0.16431,0.456,0.99,201,0.987,"mitomycin.c, estramustine.phosphate",0.00436480540245009,0.00568284733036327,FALSE +"HCC44","Pearson.est","dopamine receptor antagonist",0.5042,1.42,0.105,124,0.367,"acetophenazine, piperacetazine, UH.232...., oxiperomide, lurasidone",0.978810700930062,0.435333935747911,FALSE +"HCC44","Pearson.est","estrogen receptor agonist",0.51028,1.41,0.104,74,0.352,"estradiol, estrone",0.98296666070122,0.453457336521869,FALSE +"HCC44","Pearson.est","FGFR inhibitor",-0.24287,-0.776,0.763,281,0.885,"dovitinib, nintedanib, regorafenib, MK.2461, lucitanib, erdafitinib, AZD4547, lenvatinib",0.11747546204512,0.0530567293021746,FALSE +"HCC44","Pearson.est","FLT3 inhibitor",0.39417,1.06,0.416,282,0.605,"sunitinib, KW.2449, sorafenib, tozasertib, TG.02, lestaurtinib, dovitinib",0.380906669373257,0.218244625347531,FALSE +"HCC44","Pearson.est","glucocorticoid receptor agonist",0.64499,1.79,0.0125,274,0.188,"deflazacort, triamcinolone, ciclesonide, fludroxycortide, fluorometholone, halobetasol.propionate, rimexolone, fluocinolone.acetonide, flumethasone.pivalate, halcinonide, clobetasol.propionate, flumethasone, difluprednate",1.90308998699194,0.72584215073632,TRUE +"HCC44","Pearson.est","glutamate receptor antagonist",-0.24699,-0.756,0.776,967,0.88,"felbamate, CGP.37849",0.110138278741812,0.0555173278498314,FALSE +"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.35955,-1.11,0.298,416,1,"indirubin, GSK.3.inhibitor.IX, kenpaullone, LY2090314, CHIR.98014, TWS.119, tideglusib, AZD2858",0.525783735923745,0,FALSE +"HCC44","Pearson.est","HDAC inhibitor",-0.42036,-1.34,0.139,852,0.808,"tacedinaline, vorinostat, M.344, AR.42, chidamide, pyroxamide, entinostat, dacinostat, panobinostat, SB.939, romidepsin, resminostat",0.856985199745905,0.0925886392254138,FALSE +"HCC44","Pearson.est","histamine receptor antagonist",0.20063,0.538,0.945,412,0.982,"epinastine, astemizole, ranitidine, levocetirizine, tiotidine, BF2.649",0.0245681914907371,0.00788851221305034,FALSE +"HCC44","Pearson.est","HSP inhibitor",-0.7409,-2.31,0.00621,981,0.0458,"NMS.E973, NVP.AUY922, alvespimycin, ganetespib, tanespimycin, BIIB021, SNX.5422, VER.49009",2.20690839982342,1.33913452199613,TRUE +"HCC44","Pearson.est","JAK inhibitor",0.23666,0.658,0.883,305,0.914,"tozasertib, TG.02, lestaurtinib, atiprimod, TG.101209",0.0540392964224314,0.0390538042661686,FALSE +"HCC44","Pearson.est","KIT inhibitor",0.47037,1.31,0.174,102,0.444,"masitinib, KI.8751, sunitinib, sorafenib",0.7594507517174,0.35261702988538,FALSE +"HCC44","Pearson.est","MEK inhibitor",0.42679,1.19,0.24,423,0.554,"trametinib, PD.198306, PD.318088, TAK.733, PD.0325901, cobimetinib, AZD8330, MEK162, AS.703026, nobiletin, arctigenin",0.619788758288394,0.25649023527157,FALSE +"HCC44","Pearson.est","microtubule inhibitor",0.4638,1.27,0.187,436,0.479,"colchicine, vinflunine, vinblastine, estramustine.phosphate, D.64131, cytochalasin.b, secnidazole, podophyllotoxin",0.728158393463501,0.319664486585437,FALSE +"HCC44","Pearson.est","mTOR inhibitor",-0.24972,-0.754,0.755,1022,0.845,"PI.103, deforolimus, GSK2126458, SB.2343, PP242",0.122053048370812,0.0731432910503077,FALSE +"HCC44","Pearson.est","NFkB pathway inhibitor",-0.33076,-1.03,0.393,1046,0.78,"bindarit, Ro.106.9920, parthenolide",0.405607449624573,0.10790539730952,FALSE +"HCC44","Pearson.est","p38 MAPK inhibitor",0.39018,1.07,0.384,191,0.643,"skepinone.l, CMPD.1",0.415668775632469,0.191789027075778,FALSE +"HCC44","Pearson.est","PARP inhibitor",-0.37456,-1.14,0.282,886,1,"niraparib, olaparib, PJ.34, E7449, endo.IWR.1",0.549750891680639,0,FALSE +"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.39769,1.08,0.37,106,0.657,"masitinib, KI.8751, sunitinib, axitinib, sorafenib, crenolanib",0.431798275933005,0.182434630440219,FALSE +"HCC44","Pearson.est","phosphatase inhibitor",0.5874,1.6,0.0561,277,0.289,"alexidine, CID.5458317, BVT.948, mycophenolic.acid, menadione",1.25103713874384,0.539102157243452,FALSE +"HCC44","Pearson.est","phosphodiesterase inhibitor",-0.52049,-1.6,0.0685,946,0.55,"enoximone, trequinsin, anagrelide, EMD.53998",1.16430942850757,0.259637310505756,FALSE +"HCC44","Pearson.est","PI3K inhibitor",-0.43984,-1.37,0.152,901,0.918,"taselisib, buparlisib, PF.05212384, TG100.115, idelalisib, CUDC.907, PI.103, TG.100713, CH5132799, GSK2126458, GDC.0941, SB.2343",0.818156412055227,0.0371573187987575,FALSE +"HCC44","Pearson.est","PLK inhibitor",0.34188,0.962,0.476,372,0.614,"rigosertib, NMS.1286937, GSK461364",0.322393047279507,0.211831628858832,FALSE +"HCC44","Pearson.est","progesterone receptor agonist",0.30424,0.839,0.642,205,0.774,"melengestrol.acetate, norgestrel",0.192464971931147,0.111259039317107,FALSE +"HCC44","Pearson.est","proteasome inhibitor",0.7695,2.16,0.00297,270,0.0228,"oprozomib, carfilzomib, ixazomib.citrate, ixazomib, bortezomib, ONX.0914",2.52724355068279,1.64206515299955,TRUE +"HCC44","Pearson.est","protein synthesis inhibitor",0.59364,1.63,0.0379,297,0.295,"florfenicol, harringtonine, anguidine, bruceantin, chloramphenicol.palmitate, puromycin, tedizolid.phosphate, mercaptopurine, brefeldin.a, methacycline, cycloheximide, azomycin..2.nitroimidazole.",1.42136079003193,0.530177984021837,FALSE +"HCC44","Pearson.est","protein tyrosine kinase inhibitor",0.5126,1.42,0.108,347,0.367,"rheochrysidin, mubritinib, tyrphostin.A9",0.96657624451305,0.435333935747911,FALSE +"HCC44","Pearson.est","RAF inhibitor",0.52678,1.45,0.0929,360,0.448,"vemurafenib, sorafenib, dabrafenib, RAF265, LGX818, CEP.32496, AZ.628",1.03198428600636,0.348721986001856,FALSE +"HCC44","Pearson.est","retinoid receptor agonist",-0.28756,-0.893,0.529,333,0.723,"fenretinide, LE.135, adapalene, bexarotene, CD.437, AM.580, tamibarotene",0.276544327964814,0.140861702705469,FALSE +"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.29934,-0.942,0.495,895,0.751,"clofarabine, fludarabine, gemcitabine, fludarabine.phosphate, LY2334737",0.305394801066431,0.124360062995832,FALSE +"HCC44","Pearson.est","serotonin receptor antagonist",0.37048,1.03,0.426,409,0.558,"SB.228357, lurasidone, SB.200646, ziprasidone",0.370590400897281,0.253365801062421,FALSE +"HCC44","Pearson.est","sodium channel blocker",0.37076,1.06,0.397,317,0.605,"quinidine, A.803467, triamterene, butamben, lappaconite",0.401209493236885,0.218244625347531,FALSE +"HCC44","Pearson.est","src inhibitor",-0.30721,-0.912,0.526,892,0.726,"dasatinib, saracatinib, bosutinib, TG.100572",0.279014255846261,0.139063379299906,FALSE +"HCC44","Pearson.est","sterol demethylase inhibitor",0.63974,1.8,0.0147,307,0.27,"ketoconazole, lanoconazole, terconazole, chlormidazole, sulconazole",1.83268266525182,0.568636235841013,FALSE +"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.239,-0.734,0.751,277,0.838,"carmofur, raltitrexed, ftorafur, capecitabine, doxifluridine, trifluridine",0.124360062995832,0.0767559813697235,FALSE +"HCC44","Pearson.est","topoisomerase inhibitor",0.44015,1.22,0.23,414,0.535,"beta.lapachone, valrubicin, irinotecan, dexrazoxane, etoposide.phosphate, camptothecin, TAS.103, teniposide, amonafide, daunorubicin, topotecan, etoposide",0.638272163982407,0.271646217978772,FALSE +"HCC44","Pearson.est","tubulin polymerization inhibitor",0.60467,1.66,0.0314,459,0.311,"albendazole, mebendazole, parbendazole, verubulin, vincristine, vinblastine, ABT.751, plinabulin, indibulin, vindesine, combretastatin.A.4, CYT.997, taltobulin, vinorelbine, flubendazole, docetaxel, dolastatin.10, paclitaxel, BNC105, epothilone.d, podophyllotoxin, nocodazole, oxibendazole",1.50307035192679,0.507239610973163,FALSE +"HCC44","Pearson.est","tyrosine kinase inhibitor",0.5393,1.53,0.0782,351,0.354,"sunitinib, apatinib, sorafenib, aminopurvalanol.a, rheochrysidin, cabozantinib, tivantinib, mubritinib, bafetinib, tyrphostin.A9, AMG.208",1.10679324694015,0.450996737974212,FALSE +"HCC44","Pearson.est","VEGFR inhibitor",0.27644,0.786,0.715,399,0.802,"KI.8751, sunitinib, axitinib, sorafenib, RAF265, cabozantinib, dovitinib, nintedanib, ZM.306416, vatalanib, SU014813, golvatinib",0.145693958198919,0.0958256317158365,FALSE +"HCC44","Pearson.est","vitamin D receptor agonist",-0.33687,-1.07,0.354,894,0.911,"alfacalcidol, doxercalciferol, maxacalcitol",0.450996737974212,0.0404816230270017,FALSE +"H1299","Pearson.est","EGFR inhibitor",0.53844,1.56,0.0822,350,0.221,"osimertinib, poziotinib, afatinib, tucatinib, dacomitinib, canertinib, tyrphostin.AG.494, AZD8931, pelitinib, erlotinib, ARRY.334543, BIBX.1382, CP.724714, PD.168393, neratinib, vandetanib, PD.153035, XL.647, BIBU.1361, WZ.4002, CNX.2006, gefitinib, TAK.285, BMS.690514, lapatinib",1.08512818245995,0.655607726314889,FALSE +"H1299","Pearson.est","Abl kinase inhibitor",-0.5501,-1.45,0.109,972,0.408,"metatinib, tozasertib, imatinib, flumatinib, nilotinib, KW.2449, GZD824",0.962573502059376,0.38933983691012,FALSE +"H1299","Pearson.est","adenosine receptor antagonist",0.60468,1.73,0.0409,158,0.264,"SCH.58261, PSB.1115, istradefylline",1.38827669199266,0.578396073130169,FALSE +"H1299","Pearson.est","adrenergic receptor agonist",0.545,1.56,0.0705,150,0.221,"lidamidine, A61603, isoetharine, ritodrine, norepinephrine, xylazine",1.1518108830086,0.655607726314889,FALSE +"H1299","Pearson.est","adrenergic receptor antagonist",0.55908,1.61,0.0426,229,0.331,"prazosin, naftidrofuryl, atenolol...., pindolol, propranolol, imiloxan",1.37059040089728,0.480172006224281,FALSE +"H1299","Pearson.est","AKT inhibitor",-0.31407,-0.844,0.631,695,0.819,"GSK2110183, CCT128930, GDC.0068, uprosertib, AZD5363, triciribine, MK.2206, A.674563",0.199970640755866,0.0867160982395816,FALSE +"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.2079,0.595,0.949,1074,0.931,"SB.505124, GW.788388, AZD3463, DMH1, NVP.TAE684, CEP.37440, crizotinib, brigatinib, lorlatinib, alectinib, AP26113",0.0227337875727074,0.0310503190186574,FALSE +"H1299","Pearson.est","antioxidant",0.69234,1.98,0.0114,369,0.157,"rutin, trolox, benfotiamine, taurine, chlorogenic.acid",1.94309514866353,0.804100347590766,TRUE +"H1299","Pearson.est","AP inhibitor",-0.71722,-1.89,0.00657,1310,0.336,"birinapant, GDC.0152, LCL.161",2.18243463044022,0.473660722610156,FALSE +"H1299","Pearson.est","ATPase inhibitor",-0.68567,-1.84,0.00939,1034,0.248,"blebbistatin...., NMS.873, digitoxigenin, ouabain, omeprazole, digitoxin",2.02733440773389,0.605548319173784,TRUE +"H1299","Pearson.est","Aurora kinase inhibitor",-0.62085,-1.67,0.032,922,0.481,"MK.8745, GSK1070916, aurora.a.inhibitor.i, AT.9283, tozasertib, ENMD.2076, TAK.901, PHA.680632, barasertib, ZM.447439, MK.5108, KW.2449, CCT137690, danusertib, CCT129202, CYC116, AMG900, SNS.314, PF.03814735, barasertib.HQPA",1.49485002168009,0.317854923626168,FALSE +"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.30271,-0.812,0.693,1316,0.849,"tedizolid",0.159266765388193,0.0710923097560473,FALSE +"H1299","Pearson.est","BCL inhibitor",-0.49357,-1.33,0.157,995,0.362,"TW.37, oridonin, venetoclax, ABT.737, HA14.1",0.804100347590766,0.441291429466834,FALSE +"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.55374,-1.49,0.0845,972,0.47,"metatinib, tozasertib, imatinib, flumatinib, nilotinib, GZD824",1.07314329105031,0.327902142064283,FALSE +"H1299","Pearson.est","benzodiazepine receptor agonist",0.40619,1.19,0.251,429,0.441,"gamma.aminobutyric.acid, eprinomectin, indiplon, zaleplon, temazepam, CL.218872, nefiracetam",0.600326278518962,0.355561410532161,FALSE +"H1299","Pearson.est","calcium channel blocker",-0.57566,-1.51,0.0756,939,0.493,"efonidipine.monoethanolate, pranidipine, penfluridol, carboxyamidotriazole, SR.33805, tetrandrine, SKF.96365",1.12147820449879,0.30715308072277,FALSE +"H1299","Pearson.est","CC chemokine receptor antagonist",-0.37115,-0.987,0.456,1185,0.648,"RS.504393",0.341035157335565,0.188424994129407,FALSE +"H1299","Pearson.est","CDK inhibitor",-0.46332,-1.23,0.227,924,0.433,"palbociclib, TG.02, dinaciclib, BMS.265246, aminopurvalanol.a, arcyriaflavin.a, AZD5438, alvocidib, PHA.793887, indisulam, kenpaullone, AT.7519, BMS.387032",0.643974142806877,0.363512103646635,FALSE +"H1299","Pearson.est","CHK inhibitor",-0.52486,-1.38,0.132,997,0.427,"AZD7762, SB.218078, CHIR.124, PF.477736",0.87942606879415,0.369572124974976,FALSE +"H1299","Pearson.est","cyclooxygenase inhibitor",-0.28511,-0.766,0.75,1112,0.875,"curcumin, piroxicam, aspirin, acetylsalicylsalicylic.acid, indoprofen, AM.404",0.1249387366083,0.0579919469776868,FALSE +"H1299","Pearson.est","cytochrome P450 inhibitor",0.53703,1.53,0.0972,246,0.219,"eplerenone, morin, PF.4981517",1.01233373507373,0.659555885159882,FALSE +"H1299","Pearson.est","DNA alkylating agent",-0.33262,-0.894,0.576,1018,0.784,"estramustine, TH.302, dianhydrogalactitol, melphalan, cyclophosphamide, mitomycin.c",0.239577516576788,0.105683937315562,FALSE +"H1299","Pearson.est","DNA inhibitor",0.23899,0.672,0.845,213,0.962,"mechlorethamine, nimorazole, metronidazole, carboplatin, tirapazamine",0.0731432910503077,0.0168249279621871,FALSE +"H1299","Pearson.est","DNA methyltransferase inhibitor",-0.48309,-1.27,0.202,819,0.41,"disulfiram, decitabine, fdcyd",0.694648630553376,0.387216143280265,FALSE +"H1299","Pearson.est","DNA polymerase inhibitor",0.32615,0.916,0.516,914,0.674,"famciclovir, idoxuridine, cidofovir, foscarnet, cephalomannine, trifluridine, adefovir.dipivoxil",0.287350298372789,0.17134010346468,FALSE +"H1299","Pearson.est","DNA synthesis inhibitor",-0.2076,-0.548,0.942,1221,0.976,"mitomycin.c, altretamine",0.0259490972071227,0.0105501823333082,FALSE +"H1299","Pearson.est","dopamine receptor antagonist",-0.27888,-0.752,0.743,1181,0.851,"isofloxythepin, acetophenazine, raclopride, piperacetazine",0.129011186239425,0.0700704399154121,FALSE +"H1299","Pearson.est","estrogen receptor agonist",0.44305,1.31,0.16,8,0.415,"levonorgestrel",0.795880017344075,0.381951903287907,FALSE +"H1299","Pearson.est","estrogen receptor antagonist",0.62616,1.83,0.0187,131,0.22,"raloxifene, clomifene, danazol",1.7281583934635,0.657577319177794,TRUE +"H1299","Pearson.est","FGFR inhibitor",-0.23053,-0.614,0.906,940,0.949,"nintedanib, orantinib, lucitanib",0.0428718023231869,0.0227337875727074,FALSE +"H1299","Pearson.est","FLT3 inhibitor",-0.52513,-1.38,0.142,973,0.427,"TG.02, tozasertib, tyrphostin.AG.1296, TG.101348, ENMD.2076, GTP.14564, quizartinib, midostaurin, KW.2449, lestaurtinib",0.847711655616944,0.369572124974976,FALSE +"H1299","Pearson.est","glucocorticoid receptor agonist",0.37444,1.06,0.371,267,0.484,"fludroxycortide, methylprednisolone, prednisolone.acetate, deflazacort, desonide, triamcinolone, fluocinolone.acetonide, triamcinolone.acetonide, beclomethasone.dipropionate, prednisolone.hemisuccinate",0.430626090384954,0.315154638355588,FALSE +"H1299","Pearson.est","glutamate receptor antagonist",0.38652,1.15,0.274,310,0.414,"JNJ.16259685, felbamate, CGP.37849, kynurenic.acid, SIB.1757, CPP, diazooxonorleucine",0.562249437179612,0.382999658879101,FALSE +"H1299","Pearson.est","glycogen synthase kinase inhibitor",-0.48271,-1.3,0.182,1040,0.386,"LY2090314, kenpaullone, CHIR.99021, AZD2858, CHIR.98014",0.739928612014925,0.413412695328245,FALSE +"H1299","Pearson.est","growth factor receptor inhibitor",-0.40248,-1.06,0.384,1243,0.574,"danusertib, lestaurtinib",0.415668775632469,0.241088107602027,FALSE +"H1299","Pearson.est","HDAC inhibitor",-0.43771,-1.18,0.257,984,0.469,"givinostat, PCI.24781, entinostat, AR.42, SB.939, pyroxamide, romidepsin, tacedinaline, M.344, dacinostat, mocetinostat",0.590066876668705,0.328827157284917,FALSE +"H1299","Pearson.est","histamine receptor antagonist",0.41462,1.16,0.289,290,0.426,"astemizole, famotidine, epinastine, nizatidine, zolantidine, BF2.649",0.539102157243452,0.370590400897281,FALSE +"H1299","Pearson.est","HSP inhibitor",-0.41695,-1.1,0.34,951,0.533,"alvespimycin, SNX.5422, SNX.2112, NVP.AUY922, NMS.E973, XL888, PU.H71",0.468521082957745,0.273272790973428,FALSE +"H1299","Pearson.est","JAK inhibitor",-0.39481,-1.05,0.395,953,0.57,"WHI.P154, AT.9283, TG.02, tozasertib, TG.101348, TG.101209, PRT062070, lestaurtinib",0.40340290437354,0.244125144327509,FALSE +"H1299","Pearson.est","KIT inhibitor",-0.28942,-0.756,0.75,914,0.867,"cediranib, imatinib, midostaurin, KI.8751, pazopanib, OSI.930",0.1249387366083,0.0619809025237897,FALSE +"H1299","Pearson.est","MEK inhibitor",0.43598,1.3,0.162,340,0.392,"refametinib, PD.198306, PD.184352, trametinib, TAK.733, AS.703026, PD.0325901, AZD8330, cobimetinib, PD.318088, Ro.4987655, PD.98059",0.790484985457369,0.406713932979543,FALSE +"H1299","Pearson.est","MET inhibitor",0.53817,1.59,0.055,151,0.296,"NVP.BVU972, PF.04217903",1.25963731050576,0.528708288941061,FALSE +"H1299","Pearson.est","microtubule inhibitor",-0.43628,-1.14,0.317,933,0.491,"vinblastine, vinflunine, D.64131, colchicine, cabazitaxel",0.498940737782249,0.308918507877032,FALSE +"H1299","Pearson.est","mTOR inhibitor",-0.43431,-1.15,0.283,892,0.495,"ku.0063794, PI.103, WYE.354, WYE.125132, AZD8055, PF.04691502, PKI.179, XL388, OSI.027, deforolimus, sirolimus, torin.2, torin.1, PF.05212384",0.54821356447571,0.305394801066431,FALSE +"H1299","Pearson.est","NFkB pathway inhibitor",-0.54396,-1.45,0.11,856,0.408,"bindarit, betulinic.acid, EVP4593, Ro.106.9920, BAY.11.7085, curcumin, tyloxapol, parthenolide",0.958607314841775,0.38933983691012,FALSE +"H1299","Pearson.est","opioid receptor agonist",0.40015,1.16,0.261,814,0.426,"salvinorin.a, BW.180C, trimebutine, ADL5859, cebranopadol, spiradoline",0.583359492661719,0.370590400897281,FALSE +"H1299","Pearson.est","p38 MAPK inhibitor",0.21422,0.617,0.916,121,0.947,"SB.242235",0.0381045263321496,0.0236500209967266,FALSE +"H1299","Pearson.est","PARP inhibitor",-0.56113,-1.51,0.0767,983,0.493,"niraparib, olaparib, talazoparib, PJ.34",1.11520463605102,0.30715308072277,FALSE +"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.27714,-0.735,0.774,940,0.854,"nintedanib, orantinib, imatinib, axitinib, crenolanib, CP.673451, KI.8751, pazopanib",0.111259039317107,0.068542129310995,FALSE +"H1299","Pearson.est","phosphatase inhibitor",-0.52213,-1.37,0.136,806,0.415,"alexidine, GSK2830371, sodium.stibogluconate, mycophenolic.acid, CID.5458317",0.866461091629782,0.381951903287907,FALSE +"H1299","Pearson.est","phosphodiesterase inhibitor",0.25084,0.748,0.791,461,0.93,"enoximone, trequinsin, avanafil, YM.976, papaverine",0.101823516502323,0.0315170514460649,FALSE +"H1299","Pearson.est","PI3K inhibitor",0.23334,0.651,0.887,34,0.947,"GDC.0980, idelalisib, alpelisib",0.0520763801682736,0.0236500209967266,FALSE +"H1299","Pearson.est","PLK inhibitor",-0.45409,-1.23,0.245,744,0.433,"GSK461364, HMN.214, BI.2536, rigosertib, volasertib",0.610833915635468,0.363512103646635,FALSE +"H1299","Pearson.est","progesterone receptor agonist",0.54307,1.56,0.0588,131,0.221,"levonorgestrel, norgestrel, nomegestrol.acetate, danazol",1.23062267392386,0.655607726314889,FALSE +"H1299","Pearson.est","proteasome inhibitor",-0.61763,-1.65,0.0334,862,0.405,"carfilzomib, ixazomib, ONX.0914, oprozomib, ixazomib.citrate, delanzomib, MG.132",1.47625353318844,0.392544976785331,FALSE +"H1299","Pearson.est","protein synthesis inhibitor",-0.50024,-1.35,0.145,1062,0.373,"cycloheximide, homoharringtonine, bruceantin, harringtonine, anguidine, methacycline, florfenicol, mercaptopurine, tedizolid.phosphate, thiostrepton",0.838631997765025,0.428291168191312,FALSE +"H1299","Pearson.est","protein tyrosine kinase inhibitor",-0.50345,-1.35,0.153,1234,0.373,"BMS.599626, tyrphostin.A9, PP.121",0.815308569182401,0.428291168191312,FALSE +"H1299","Pearson.est","RAF inhibitor",-0.4455,-1.2,0.245,1131,0.458,"PLX.4720, RAF265, CEP.32496, SB.590885",0.610833915635468,0.339134521996131,FALSE +"H1299","Pearson.est","RET tyrosine kinase inhibitor",0.36451,1.07,0.326,862,0.495,"vandetanib, regorafenib, sorafenib, apatinib, sunitinib, cabozantinib",0.486782399932061,0.305394801066431,FALSE +"H1299","Pearson.est","retinoid receptor agonist",-0.59604,-1.59,0.0537,934,0.463,"adapalene, fenretinide, CD.437, tamibarotene, LE.135",1.27002571430044,0.334419008982047,FALSE +"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.53023,-1.46,0.0978,947,0.479,"fludarabine.phosphate, cladribine, LY2334737, triapine, clofarabine",1.0096611452124,0.319664486585437,FALSE +"H1299","Pearson.est","serotonin receptor antagonist",-0.18027,-0.482,0.991,1266,0.983,"lerisetron",0.00392634551472468,0.00744648216786438,FALSE +"H1299","Pearson.est","sodium channel blocker",-0.52735,-1.42,0.116,1138,0.424,"brivaracetam, cibenzoline, benzocaine, benzethonium, ajmaline",0.935542010773082,0.372634143407267,FALSE +"H1299","Pearson.est","src inhibitor",0.24702,0.697,0.812,304,0.969,"PP.1, masitinib, saracatinib",0.0904439707588247,0.0136762229492347,FALSE +"H1299","Pearson.est","sterol demethylase inhibitor",-0.28395,-0.773,0.724,974,0.888,"sulconazole, terconazole",0.140261433802853,0.051587034221399,FALSE +"H1299","Pearson.est","TGF beta receptor inhibitor",0.43451,1.29,0.171,159,0.372,"SB.431542, LY2109761",0.767003889607846,0.429457060118102,FALSE +"H1299","Pearson.est","thymidylate synthase inhibitor",0.42217,1.25,0.186,89,0.392,"carmofur, capecitabine",0.730487055782084,0.406713932979543,FALSE +"H1299","Pearson.est","topoisomerase inhibitor",-0.49806,-1.36,0.13,946,0.405,"teniposide, rubitecan, irinotecan, doxorubicin, valrubicin, topotecan, genz.644282, beta.lapachone, etoposide, exatecan.mesylate, nemorubicin, epirubicin, etoposide.phosphate, voreloxin, dexrazoxane",0.886056647693163,0.392544976785331,FALSE +"H1299","Pearson.est","tubulin polymerization inhibitor",-0.50412,-1.34,0.165,708,0.367,"oxibendazole, CYT.997, plinabulin, epothilone.b, podophyllotoxin, dolastatin.10, verubulin, vincristine, flubendazole, indibulin, vindesine, BNC105, vinblastine, fosbretabulin, mebendazole, combretastatin.A.4, docetaxel, fenbendazole, paclitaxel, KX2.391, parbendazole, nocodazole, taltobulin, albendazole, vinorelbine",0.782516055786094,0.435333935747911,FALSE +"H1299","Pearson.est","tyrosine kinase inhibitor",-0.31868,-0.849,0.635,861,0.835,"cabozantinib, NVP.TAE226, AV.412, aminopurvalanol.a, GTP.14564, UNC2250, tivantinib, BMS.599626, tyrphostin.A9, PP.121",0.197226274708024,0.0783135245163979,FALSE +"H1299","Pearson.est","VEGFR inhibitor",-0.23636,-0.648,0.885,914,0.937,"cediranib, nintedanib, orantinib, semaxanib, axitinib, ENMD.2076, lucitanib, RAF265, KI.8751, AEE788, pazopanib, OSI.930",0.0530567293021746,0.0282604091122217,FALSE +"H1299","Pearson.est","vitamin D receptor agonist",0.76861,2.2,0,228,0.0564,"calcitriol, maxacalcitol, tacalcitol, doxercalciferol, alfacalcidol",Inf,1.24872089601666,TRUE +"H1703","Pearson.est","EGFR inhibitor",0.24664,0.739,0.77,565,0.895,"BMS.599626, OSI.420, PD.168393, TAK.285, osimertinib, lapatinib, WZ.4002, AEE788, erlotinib, BMS.690514, ARRY.334543, neratinib, GW.583340, vandetanib, pelitinib, tucatinib, PD.153035, BIBX.1382, afatinib, AZD8931, canertinib, XL.647, dacomitinib",0.113509274827518,0.048176964684088,FALSE +"H1703","Pearson.est","Abl kinase inhibitor",-0.41455,-1.22,0.234,1061,0.633,"bosutinib, ponatinib, dasatinib, flumatinib, bafetinib, GZD824",0.630784142589857,0.198596289982645,FALSE +"H1703","Pearson.est","acetylcholine receptor agonist",0.39084,1.2,0.252,70,0.684,"oxiracetam, nefiracetam",0.598599459218456,0.164943898279884,FALSE +"H1703","Pearson.est","acetylcholine receptor antagonist",-0.5153,-1.51,0.0942,995,0.615,"dicycloverine, iododexetimide, hyoscyamine, diphemanil",1.02594909720712,0.211124884224583,FALSE +"H1703","Pearson.est","adenosine receptor antagonist",-0.25729,-0.749,0.743,752,0.852,"PSB.1115, theophylline, MRS.1220, SCH.58261",0.129011186239425,0.0695604052332999,FALSE +"H1703","Pearson.est","adrenergic receptor agonist",-0.29236,-0.877,0.588,841,0.798,"A61603, methyldopa, ritodrine, norepinephrine, metaraminol, buphenine, xylazine, epinephrine, isoetharine",0.230622673923862,0.0979971086492706,FALSE +"H1703","Pearson.est","adrenergic receptor antagonist",0.31959,0.949,0.498,250,0.899,"RS.17053, atenolol...., dihydroergocristine, idazoxan, vincamine",0.302770657240282,0.0462403082667712,FALSE +"H1703","Pearson.est","AKT inhibitor",0.51674,1.54,0.0792,429,1,"ONC201, MK.2206, palomid.529, GSK2110183, GDC.0068, AZD5363, CCT128930, triciribine",1.10127481841051,0,FALSE +"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.48621,-1.4,0.133,1350,0.77,"GW.788388, DMH1, SB.505124",0.876148359032914,0.113509274827518,FALSE +"H1703","Pearson.est","antioxidant",-0.29584,-0.861,0.613,1170,0.8,"mesna, chlorogenic.acid",0.212539525481585,0.0969100130080564,FALSE +"H1703","Pearson.est","AP inhibitor",-0.30177,-0.882,0.559,1240,0.818,"GDC.0152, birinapant",0.252588192113577,0.087246696328677,FALSE +"H1703","Pearson.est","ATPase inhibitor",0.4268,1.29,0.187,278,0.664,"rabeprazole, digitoxigenin, thonzonium, digitoxin",0.728158393463501,0.177831920631982,FALSE +"H1703","Pearson.est","Aurora kinase inhibitor",-0.42279,-1.23,0.227,1271,0.659,"TAK.901, CYC116, GSK1070916, danusertib, barasertib.HQPA, SNS.314, AT.9283, hesperadin",0.643974142806877,0.18111458540599,FALSE +"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.21954,-0.64,0.87,966,0.939,"tilmicosin, azalomycin.b, radezolid",0.0604807473813815,0.0273344077338891,FALSE +"H1703","Pearson.est","bacterial DNA gyrase inhibitor",-0.69109,-2.05,0.00193,1145,0.0982,"lomefloxacin, nadifloxacin, sarafloxacin, novobiocin, trovafloxacin, finafloxacin",2.71444269099223,1.00788851221305,TRUE +"H1703","Pearson.est","BCL inhibitor",-0.23616,-0.687,0.791,907,0.911,"navitoclax, obatoclax, ABT.737, HA14.1",0.101823516502323,0.0404816230270017,FALSE +"H1703","Pearson.est","Bcr.Abl kinase inhibitor",-0.45762,-1.32,0.203,1061,0.636,"bosutinib, ponatinib, dasatinib, flumatinib, bafetinib, GZD824",0.692503962086787,0.196542884351586,FALSE +"H1703","Pearson.est","benzodiazepine receptor agonist",0.2508,0.759,0.739,123,0.892,"eprinomectin, nefiracetam, lorazepam",0.131355561605174,0.0496351456238769,FALSE +"H1703","Pearson.est","bromodomain inhibitor",-0.71574,-2.09,0.00571,1095,0.146,"I.BET151, OTX015, JQ1...., bromosporine",2.24336389175415,0.835647144215563,TRUE +"H1703","Pearson.est","calcium channel blocker",0.32354,0.978,0.449,160,0.881,"fendiline, tetrandrine, penfluridol",0.347753658996677,0.0550240915879521,FALSE +"H1703","Pearson.est","CC chemokine receptor antagonist",-0.26318,-0.755,0.731,887,0.868,"PF.04136309, SB.225002, RS.504393",0.13608262304214,0.0614802748235081,FALSE +"H1703","Pearson.est","CDK inhibitor",0.2322,0.693,0.829,393,0.907,"AZD5438, CR8..R., ribociclib, arcyriaflavin.a, aminopurvalanol.a, NU6027, indisulam, BMS.265246",0.0814454694497265,0.0423927129399047,FALSE +"H1703","Pearson.est","CHK inhibitor",0.29018,0.876,0.562,468,0.896,"LY2606368, AZD7762, CHIR.124, SB.218078",0.250263684430939,0.0476919903378748,FALSE +"H1703","Pearson.est","cyclooxygenase inhibitor",-0.3192,-0.932,0.506,946,0.89,"ketoprofen, FK.3311, ramifenazone, tepoxalin, aspirin, pterostilbene, sulfasalazine, indoprofen, piroxicam, amfenac, phenazone",0.295849483160201,0.0506099933550872,FALSE +"H1703","Pearson.est","cytochrome P450 inhibitor",0.26476,0.784,0.695,356,0.876,"cobicistat, metyrapone, clotrimazole",0.158015195409886,0.0574958938319193,FALSE +"H1703","Pearson.est","DNA alkylating agent",0.26855,0.803,0.654,117,0.902,"estramustine, satraplatin, TH.302",0.184422251675733,0.0447934624580583,FALSE +"H1703","Pearson.est","DNA inhibitor",0.3525,1.06,0.361,118,0.834,"oxaliplatin, sangivamycin, pibenzimol, busulfan",0.442492798094342,0.0788339493622613,FALSE +"H1703","Pearson.est","DNA methyltransferase inhibitor",0.23075,0.693,0.837,432,0.907,"fdcyd, SGI.1027, disulfiram",0.07727454200674,0.0423927129399047,FALSE +"H1703","Pearson.est","DNA polymerase inhibitor",0.43353,1.32,0.164,78,0.74,"idoxuridine, cidofovir",0.785156151952302,0.130768280269024,FALSE +"H1703","Pearson.est","DNA synthesis inhibitor",0.43571,1.3,0.188,183,0.709,"CB.10.277, azodicarbonamide, capecitabine, enocitabine, floxuridine",0.72584215073632,0.149353764816933,FALSE +"H1703","Pearson.est","dopamine receptor antagonist",0.28491,0.88,0.562,151,0.926,"sertindole, paliperidone, oxiperomide, nemonapride",0.250263684430939,0.0333890133180656,FALSE +"H1703","Pearson.est","estrogen receptor agonist",-0.30193,-0.889,0.574,1245,0.866,"PPT, erteberel",0.241088107602027,0.0624821079826534,FALSE +"H1703","Pearson.est","estrogen receptor antagonist",0.35064,1.05,0.35,481,0.768,"raloxifene, fulvestrant, clomifene, danazol",0.455931955649724,0.114638779968488,FALSE +"H1703","Pearson.est","FGFR inhibitor",0.48051,1.45,0.103,96,0.737,"orantinib, lucitanib, lenvatinib",0.987162775294828,0.132532512140949,FALSE +"H1703","Pearson.est","FLT3 inhibitor",0.29223,0.866,0.574,23,0.848,"tandutinib, sorafenib",0.241088107602027,0.0716041477432862,FALSE +"H1703","Pearson.est","glucocorticoid receptor agonist",-0.19081,-0.561,0.951,883,0.962,"fluticasone.propionate, fludroxycortide, triamcinolone, prednisolone, halcinonide, methylprednisolone, beclomethasone.dipropionate, clobetasol.propionate, flumethasone.pivalate, prednisolone.hemisuccinate, betamethasone",0.0218194830625861,0.0168249279621871,FALSE +"H1703","Pearson.est","glutamate receptor antagonist",-0.33194,-0.965,0.503,905,0.861,"ACDPP, tiletamine, kynurenic.acid, diazooxonorleucine, latrepirdine, IEM1754",0.298432014944073,0.0649968485463452,FALSE +"H1703","Pearson.est","glycogen synthase kinase inhibitor",-0.29098,-0.854,0.604,1213,0.785,"CHIR.99021, tideglusib",0.218963061378868,0.105130343254747,FALSE +"H1703","Pearson.est","growth factor receptor inhibitor",-0.31571,-0.925,0.535,1096,0.868,"GSK1838705A, GSK1904529A, danusertib",0.271646217978772,0.0614802748235081,FALSE +"H1703","Pearson.est","HDAC inhibitor",0.401,1.21,0.234,231,0.715,"entinostat, PCI.24781, romidepsin, givinostat, M.344, scriptaid, JNJ.26481585, NSC.3852, ACY.1215, R306465",0.630784142589857,0.145693958198919,FALSE +"H1703","Pearson.est","histamine receptor antagonist",0.21958,0.656,0.832,438,0.877,"levocetirizine, astemizole, zolantidine, tiotidine, nizatidine, ranitidine, cyproheptadine, lafutidine",0.0798766737092761,0.0570004066339595,FALSE +"H1703","Pearson.est","HMGCR inhibitor",-0.58065,-1.71,0.0377,1212,0.316,"pitavastatin, mevastatin, atorvastatin, lovastatin",1.42365864979421,0.500312917381596,FALSE +"H1703","Pearson.est","HSP inhibitor",0.29159,0.865,0.579,465,0.82,"PU.H71, guanidine, SNX.2112, alvespimycin, SNX.5422, BIIB021, XL888, KW.2478",0.237321436272564,0.0861861476162833,FALSE +"H1703","Pearson.est","JAK inhibitor",-0.33407,-0.993,0.426,1071,0.885,"CEP.33779, filgotinib, WHI.P154, ruxolitinib, baricitinib, AT.9283",0.370590400897281,0.0530567293021746,FALSE +"H1703","Pearson.est","KIT inhibitor",0.47297,1.42,0.121,240,0.698,"tandutinib, sorafenib, pazopanib, lenvatinib, masitinib, cediranib, KI.8751, vatalanib",0.91721462968355,0.156144577376839,FALSE +"H1703","Pearson.est","MDM inhibitor",-0.58258,-1.73,0.0342,1129,0.354,"idasanutlin, AMG.232, nutlin.3, serdemetan",1.46597389394386,0.450996737974212,FALSE +"H1703","Pearson.est","MEK inhibitor",-0.64077,-1.9,0.00792,1014,0.184,"trametinib, refametinib, PD.184352, cobimetinib, U.0126, MEK162, AZD8330, Ro.4987655, AS.703026, PD.0325901, TAK.733, selumetinib, PD.198306, PD.318088, MEK1.2.inhibitor",2.10127481841051,0.735182176990464,TRUE +"H1703","Pearson.est","MET inhibitor",-0.44773,-1.28,0.193,1360,0.609,"NVP.BVU972, INC.280",0.714442690992226,0.215382707367125,FALSE +"H1703","Pearson.est","microtubule inhibitor",0.22674,0.672,0.834,112,0.882,"triclabendazole, secnidazole",0.0788339493622613,0.0545314148681803,FALSE +"H1703","Pearson.est","mTOR inhibitor",0.34718,1.05,0.359,488,0.768,"ku.0063794, palomid.529, WAY.600, GSK2126458, deforolimus, LY3023414, sirolimus, LY303511, PKI.179, OSI.027, torin.2, AZD2014, everolimus, torin.1, temsirolimus, PI.103, voxtalisib",0.444905551421681,0.114638779968488,FALSE +"H1703","Pearson.est","NFkB pathway inhibitor",-0.14874,-0.429,0.994,760,0.993,"bortezomib, EVP4593, BAY.11.7082, curcumin, bindarit, parthenolide, Ro.106.9920, BAY.11.7085",0.00261361560268669,0.00305075150461883,FALSE +"H1703","Pearson.est","opioid receptor agonist",0.22498,0.685,0.825,224,0.891,"BW.180C, cebranopadol",0.0835460514500749,0.0501222959631252,FALSE +"H1703","Pearson.est","p38 MAPK inhibitor",-0.37941,-1.1,0.312,747,0.7,"SB.239063, CMPD.1, VX.702, TAK.715",0.505845405981557,0.154901959985743,FALSE +"H1703","Pearson.est","PARP inhibitor",0.29197,0.882,0.555,523,0.962,"E7449, niraparib, AZD2461, PJ.34, talazoparib",0.255707016877324,0.0168249279621871,FALSE +"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.44518,1.34,0.173,270,0.779,"orantinib, tandutinib, sorafenib, pazopanib, axitinib, lenvatinib, masitinib, KI.8751, vatalanib, linifanib",0.761953896871205,0.108462542327436,FALSE +"H1703","Pearson.est","phosphatase inhibitor",-0.47495,-1.37,0.139,1094,0.594,"menadione, GSK2830371, sodium.stibogluconate, AS.1949490, CID.5458317",0.856985199745905,0.226213555018806,FALSE +"H1703","Pearson.est","phosphodiesterase inhibitor",0.35589,1.07,0.341,347,0.863,"trequinsin, avanafil, anagrelide, enoximone",0.467245621007502,0.0639892042847904,FALSE +"H1703","Pearson.est","PI3K inhibitor",0.35334,1.07,0.358,275,0.863,"YM.201636, pilaralisib, CH5132799, GSK2126458, LY3023414, ZSTK.474, PI3K.IN.2, LY303511, TG100.115, PKI.179, taselisib",0.446116973356126,0.0639892042847904,FALSE +"H1703","Pearson.est","PLK inhibitor",-0.34332,-0.97,0.473,781,0.891,"GW.843682X, HMN.214, BI.2536, volasertib, rigosertib, NMS.1286937",0.325138859262188,0.0501222959631252,FALSE +"H1703","Pearson.est","potassium channel blocker",-0.46474,-1.37,0.133,908,0.594,"ibutilide, mepivacaine, dofetilide, oleoylethanolamide, ML133",0.876148359032914,0.226213555018806,FALSE +"H1703","Pearson.est","progesterone receptor agonist",-0.27845,-0.807,0.674,389,0.838,"melengestrol.acetate, levonorgestrel, danazol, norethindrone.acetate, norgestrel, norethindrone, nomegestrol.acetate, tanaproget, dienogest",0.17134010346468,0.0767559813697235,FALSE +"H1703","Pearson.est","proteasome inhibitor",-0.39452,-1.15,0.295,1016,0.683,"ixazomib, MG.132, oprozomib",0.530177984021837,0.165579296318467,FALSE +"H1703","Pearson.est","protein synthesis inhibitor",-0.31286,-0.921,0.523,1243,0.841,"emetine, anguidine, harringtonine, bruceantin, mercaptopurine",0.281498311132726,0.0752040042020878,FALSE +"H1703","Pearson.est","protein tyrosine kinase inhibitor",0.31288,0.935,0.527,308,0.886,"BMS.599626, AV.412, tyrphostin.A9, PP.121",0.278189384787453,0.0525662781129492,FALSE +"H1703","Pearson.est","RAF inhibitor",-0.44601,-1.31,0.191,1133,0.603,"dabrafenib, TAK.632, CEP.32496, AZ.628, LGX818, PLX.4720",0.718966632752272,0.219682687859849,FALSE +"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.51022,1.51,0.0979,48,0.719,"sorafenib, apatinib",1.00921730819686,0.143271109617117,FALSE +"H1703","Pearson.est","retinoid receptor agonist",-0.2597,-0.763,0.727,1314,0.881,"adapalene",0.138465589140962,0.0550240915879521,FALSE +"H1703","Pearson.est","ribonucleotide reductase inhibitor",0.56068,1.67,0.0413,243,1,"hydroxyurea, fludarabine.phosphate, triapine, gemcitabine, clofarabine, cladribine",1.3840499483436,0,FALSE +"H1703","Pearson.est","serotonin receptor antagonist",-0.38154,-1.14,0.291,1155,0.662,"SB.200646, SB.216641, tropisetron, lerisetron, RS.16566",0.536107011014093,0.1791420105603,FALSE +"H1703","Pearson.est","sodium channel blocker",0.19754,0.592,0.9,425,0.918,"butamben, brivaracetam, triamterene, lappaconite, mexiletine, oxcarbazepine",0.0457574905606751,0.0371573187987575,FALSE +"H1703","Pearson.est","src inhibitor",-0.40942,-1.19,0.269,1061,0.65,"bosutinib, PP.2, dasatinib, PP.1, KX2.391",0.570247719997592,0.187086643357144,FALSE +"H1703","Pearson.est","sterol demethylase inhibitor",-0.48381,-1.39,0.129,1254,0.698,"posaconazole, sulconazole",0.889410289700751,0.156144577376839,FALSE +"H1703","Pearson.est","TGF beta receptor inhibitor",0.25571,0.787,0.683,1048,0.9,"SB.431542, repsox, D.4476, SB.525334, adaprev, LY2109761",0.165579296318467,0.0457574905606751,FALSE +"H1703","Pearson.est","thymidylate synthase inhibitor",0.63346,1.89,0.0186,255,0.776,"capecitabine, raltitrexed, carmofur",1.73048705578208,0.110138278741812,FALSE +"H1703","Pearson.est","topoisomerase inhibitor",-0.21702,-0.625,0.892,909,0.931,"mitoxantrone, genz.644282, etoposide.phosphate, beta.lapachone, doxorubicin, epirubicin, topotecan, idarubicin, TAS.103, teniposide",0.0496351456238769,0.0310503190186574,FALSE +"H1703","Pearson.est","tubulin polymerization inhibitor",-0.29886,-0.883,0.607,1043,0.846,"podophyllotoxin, vindesine, verubulin, taltobulin, mebendazole, CYT.997, BNC105, vinblastine, KX2.391, oxibendazole",0.216811308924742,0.0726296369609765,FALSE +"H1703","Pearson.est","tyrosine kinase inhibitor",0.28778,0.867,0.621,308,0.879,"BMS.599626, hypericin, sorafenib, apatinib, AV.412, AMG.208, tyrphostin.A9, aminopurvalanol.a, PP.121",0.20690839982342,0.0560111249262281,FALSE +"H1703","Pearson.est","VEGFR inhibitor",0.41452,1.24,0.212,373,0.709,"orantinib, sorafenib, pazopanib, axitinib, lucitanib, lenvatinib, cediranib, KI.8751, tivozanib, vatalanib, golvatinib, linifanib, AEE788, MGCD.265, BMS.690514, TG.100572, motesanib",0.673664139071249,0.149353764816933,FALSE +"H1703","Pearson.est","vitamin D receptor agonist",0.51284,1.53,0.0977,369,0.845,"maxacalcitol, paricalcitol, calcitriol, tacalcitol, doxercalciferol",1.01010543628123,0.0731432910503077,FALSE +"H460","Pearson.est","EGFR inhibitor",-0.17666,-0.608,0.923,753,1,"PD.168393, erlotinib, BIBU.1361, icotinib, OSI.420, gefitinib, WZ.3146, tyrphostin.AG.1478, AEE788, CGP.52411, WZ.4002, AZD8931, BMS.599626, canertinib, BMS.690514, pelitinib, dacomitinib, brigatinib, GW.583340, dovitinib, CP.724714, TAK.285, osimertinib, FERb.033, afatinib, vandetanib, rociletinib, poziotinib, CNX.2006, tucatinib, salvianolic.acid.B",0.0347982989740879,0,FALSE +"H460","Pearson.est","Abl kinase inhibitor",0.37845,1.08,0.362,433,0.674,"dasatinib, GZD824, bosutinib, flumatinib, metatinib, ponatinib",0.441291429466834,0.17134010346468,FALSE +"H460","Pearson.est","acetylcholine receptor agonist",0.50599,1.42,0.0979,36,0.56,"pilocarpine, nefiracetam",1.00921730819686,0.2518119729938,FALSE +"H460","Pearson.est","acetylcholine receptor antagonist",0.46661,1.32,0.146,580,0.63,"diphemanil, iododexetimide, dicycloverine, hyoscyamine, methscopolamine",0.835647144215563,0.200659450546418,FALSE +"H460","Pearson.est","adenosine receptor antagonist",0.3059,0.876,0.618,729,0.771,"sulmazole, PSB.1115, istradefylline, MRS.1220, CGS.15943",0.209011524911184,0.112945621949043,FALSE +"H460","Pearson.est","adrenergic receptor agonist",0.39769,1.16,0.287,392,0.592,"isoetharine, xylazine, epinephrine, buphenine, A61603, clenbuterol, methyldopa, oxymetazoline",0.542118103266008,0.22767829327708,FALSE +"H460","Pearson.est","adrenergic receptor antagonist",0.20139,0.574,0.936,701,0.935,"metoprolol, naftidrofuryl, oxprenolol, propranolol, dihydroergocristine, prazosin, imiloxan, atenolol...., atipamezole, dronedarone, RS.17053",0.0287241512618947,0.0291883891274822,FALSE +"H460","Pearson.est","AKT inhibitor",0.42284,1.23,0.222,455,0.583,"AZD5363, ONC201, A.674563, palomid.529, AT7867, CCT128930, triciribine",0.653647025549361,0.234331445240986,FALSE +"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.33225,0.965,0.514,625,0.809,"GW.788388, SB.505124, DMH1, AZD3463, NVP.TAE684, crizotinib",0.289036881004724,0.0920514783877277,FALSE +"H460","Pearson.est","androgen receptor antagonist",0.54573,1.59,0.0388,403,1,"flutamide, RU.58841, bicalutamide, nilutamide",1.41116827440579,0,FALSE +"H460","Pearson.est","antioxidant",-0.43755,-1.49,0.0874,599,0.369,"taurine, chlorogenic.acid, benfotiamine, rutin, mesna, trolox",1.0584885673656,0.43297363384094,FALSE +"H460","Pearson.est","AP inhibitor",-0.56481,-1.93,0.0118,1242,0.239,"tanshinone.i, birinapant, LCL.161, GDC.0152",1.92811799269387,0.621602099051862,TRUE +"H460","Pearson.est","ATPase inhibitor",-0.14287,-0.485,0.967,1347,0.979,"rabeprazole",0.0145735259169983,0.00921730819686218,FALSE +"H460","Pearson.est","Aurora kinase inhibitor",0.41054,1.21,0.237,677,0.599,"ENMD.2076, GSK1070916, PF.03814735, SNS.314, barasertib.HQPA, CCT137690, AMG900, MLN.8054, CYC116, AT.9283, danusertib, alisertib, MK.5108, ZM.447439, hesperadin, KW.2449, aurora.a.inhibitor.i, MK.8745",0.625251653989896,0.222573177610689,FALSE +"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.38796,1.11,0.347,514,0.654,"tedizolid, tilmicosin, josamycin, valnemulin, radezolid",0.459670525209126,0.184422251675733,FALSE +"H460","Pearson.est","bacterial DNA gyrase inhibitor",-0.24146,-0.817,0.661,847,0.889,"norfloxacin, sarafloxacin, sparfloxacin, finafloxacin, nadifloxacin, trovafloxacin",0.17979854051436,0.0510982390297863,FALSE +"H460","Pearson.est","BCL inhibitor",0.23685,0.672,0.848,73,0.885,"gossypol",0.0716041477432862,0.0530567293021746,FALSE +"H460","Pearson.est","Bcr.Abl kinase inhibitor",0.50454,1.46,0.078,433,0.736,"dasatinib, GZD824, bosutinib, flumatinib, metatinib, ponatinib",1.10790539730952,0.133122185662501,FALSE +"H460","Pearson.est","benzodiazepine receptor agonist",0.41109,1.18,0.259,529,0.592,"nefiracetam, ZK.93423, eprinomectin, lorazepam, ivermectin, CL.218872, CGS.20625",0.586700235918748,0.22767829327708,FALSE +"H460","Pearson.est","bromodomain inhibitor",-0.29584,-0.99,0.448,405,0.882,"bromosporine, PFI.1, OTX015, JQ1...., I.BET151, I.BET.762",0.348721986001856,0.0545314148681803,FALSE +"H460","Pearson.est","calcium channel blocker",0.36849,1.05,0.401,684,0.716,"pranidipine, carboxyamidotriazole, efonidipine.monoethanolate, cinnarazine, mibefradil, SR.33805",0.396855627379818,0.145086977692144,FALSE +"H460","Pearson.est","CC chemokine receptor antagonist",0.32036,0.917,0.57,706,0.804,"RS.504393, PF.04136309, navarixin, ZK811752",0.244125144327509,0.0947439512515487,FALSE +"H460","Pearson.est","CDK inhibitor",0.26118,0.756,0.77,224,0.866,"JNJ.7706621, palbociclib, kenpaullone, abemaciclib, ribociclib, TG.02",0.113509274827518,0.0624821079826534,FALSE +"H460","Pearson.est","CHK inhibitor",-0.30117,-0.994,0.421,412,0.996,"SB.218078, AZD7762, LY2606368, SCH.900776, CHIR.124, PF.477736, LY2603618",0.375717904164332,0.00174066157630127,FALSE +"H460","Pearson.est","cyclooxygenase inhibitor",0.24256,0.696,0.837,660,0.891,"meloxicam, curcumin, tepoxalin, metoxibutropate, ramifenazone, suxibuzone, FR.122047, acetylsalicylsalicylic.acid, ketoprofen, tryptanthrin, FK.3311, indoprofen",0.07727454200674,0.0501222959631252,FALSE +"H460","Pearson.est","DNA alkylating agent",0.24566,0.703,0.821,874,0.898,"streptozotocin, temozolomide, dacarbazine, ifosfamide, carboplatin, dianhydrogalactitol, TH.302, melphalan, mitomycin.c",0.0856568428805592,0.0467236633326956,FALSE +"H460","Pearson.est","DNA inhibitor",0.28938,0.832,0.669,303,0.791,"metronidazole, tirapazamine, nithiamide, valrubicin, busulfan",0.174573882232177,0.101823516502323,FALSE +"H460","Pearson.est","DNA methyltransferase inhibitor",-0.26735,-0.869,0.59,366,0.954,"decitabine, fdcyd, RG108, azacitidine, disulfiram, SGI.1027",0.229147988357856,0.0204516252959049,FALSE +"H460","Pearson.est","DNA polymerase inhibitor",0.50792,1.45,0.101,530,0.673,"trifluridine, idoxuridine, cidofovir, foscarnet, famciclovir",0.995678626217357,0.171984935776023,FALSE +"H460","Pearson.est","DNA synthesis inhibitor",0.53376,1.53,0.0554,418,0.732,"capecitabine, azodicarbonamide, artesunate, nelarabine, anisomycin, floxuridine, artemisinin, CB.10.277, estramustine.phosphate",1.25649023527157,0.135488918941608,FALSE +"H460","Pearson.est","dopamine receptor antagonist",0.31592,0.9,0.577,329,0.78,"paliperidone, lurasidone, piperacetazine, oxiperomide, nemonapride, amisulpride, UH.232....",0.238824186844269,0.10790539730952,FALSE +"H460","Pearson.est","estrogen receptor agonist",0.30878,0.903,0.596,161,0.792,"estradiol, estradiol.cypionate",0.224753740259764,0.101274818410506,FALSE +"H460","Pearson.est","estrogen receptor antagonist",0.2932,0.836,0.663,375,0.801,"tamoxifen, toremifene, danazol",0.178486471595227,0.0963674839157623,FALSE +"H460","Pearson.est","FGFR inhibitor",0.4366,1.25,0.196,383,0.592,"MK.2461, AZD4547, PD.173074, nintedanib, regorafenib",0.707743928643524,0.22767829327708,FALSE +"H460","Pearson.est","FLT3 inhibitor",0.50781,1.46,0.0849,490,0.736,"gilteritinib, midostaurin, ENMD.2076, TG.02, tandutinib, lestaurtinib, quizartinib, pacritinib, ponatinib, sunitinib, TG.101348",1.07109230975605,0.133122185662501,FALSE +"H460","Pearson.est","glucocorticoid receptor agonist",0.31617,0.912,0.569,192,0.794,"methylprednisolone, clobetasol.propionate, halobetasol.propionate, ciclesonide, halcinonide, deflazacort, desonide",0.244887733604929,0.100179497572904,FALSE +"H460","Pearson.est","glutamate receptor antagonist",0.20802,0.59,0.938,176,0.94,"CGP.37849, tiletamine, latrepirdine",0.0277971616209356,0.0268721464003014,FALSE +"H460","Pearson.est","glycogen synthase kinase inhibitor",0.3285,0.934,0.549,870,0.809,"TWS.119, kenpaullone, LY2090314, CHIR.99021, CHIR.98014, tideglusib, indirubin, GSK.3.inhibitor.IX",0.260427655549908,0.0920514783877277,FALSE +"H460","Pearson.est","growth factor receptor inhibitor",0.4499,1.29,0.191,538,0.563,"GSK1838705A, lestaurtinib, AZD3463, GW.441756, danusertib",0.718966632752272,0.249491605148654,FALSE +"H460","Pearson.est","HDAC inhibitor",0.28455,0.814,0.679,952,0.803,"pyroxamide, trichostatin.a, RG2833, nexturastat.a, vorinostat, tacedinaline, NSC.3852, panobinostat, entinostat, SB.939, belinostat, mocetinostat, JNJ.26481585, AR.42, M.344, givinostat, RGFP966, R306465, resminostat, dacinostat, scriptaid, chidamide, romidepsin",0.168130225719498,0.095284454721319,FALSE +"H460","Pearson.est","histamine receptor antagonist",0.34067,0.95,0.518,426,0.819,"tecastemizole, epinastine, nizatidine, BF2.649, lafutidine, levocetirizine, famotidine, ICI.162846",0.285670240254767,0.0867160982395816,FALSE +"H460","Pearson.est","HMGCR inhibitor",0.49004,1.37,0.125,259,0.588,"lovastatin, atorvastatin, mevastatin",0.903089986991944,0.230622673923862,FALSE +"H460","Pearson.est","HSP inhibitor",0.4142,1.18,0.247,645,0.592,"guanidine, XL888, SNX.2112, NVP.AUY922, BIIB021, ganetespib, VER.49009, PU.H71",0.607303046740334,0.22767829327708,FALSE +"H460","Pearson.est","JAK inhibitor",0.49675,1.41,0.123,526,0.537,"WHI.P154, CEP.33779, ruxolitinib, AZ960, TG.02, AZD1480, lestaurtinib, PRT062070, TG.101209, pacritinib, filgotinib, TG.101348, AT.9283",0.910094888560602,0.270025714300444,FALSE +"H460","Pearson.est","KIT inhibitor",0.43992,1.29,0.179,766,0.563,"dasatinib, midostaurin, KI.8751, tandutinib, OSI.930, motesanib, regorafenib, sunitinib, masitinib, telatinib, vatalanib, lenvatinib, cediranib",0.747146969020107,0.249491605148654,FALSE +"H460","Pearson.est","MEK inhibitor",-0.28997,-0.964,0.478,600,0.846,"arctigenin, cobimetinib, refametinib, PD.184352, trametinib, PD.318088, selumetinib, U.0126, TAK.733, AS.703026, PD.198306, Ro.4987655, PD.0325901, MEK1.2.inhibitor, AZD8330, MEK162, BIX.02188",0.320572103387881,0.0726296369609765,FALSE +"H460","Pearson.est","MET inhibitor",0.43629,1.24,0.202,657,0.587,"PHA.665752, NVP.BVU972, INC.280, PF.04217903, LY2801653",0.694648630553376,0.231361898752386,FALSE +"H460","Pearson.est","microtubule inhibitor",0.33885,0.976,0.472,612,0.83,"secnidazole, estramustine.phosphate, triclabendazole, cabazitaxel",0.326058001365912,0.0809219076239261,FALSE +"H460","Pearson.est","mTOR inhibitor",0.30775,0.885,0.593,695,0.772,"PP242, palomid.529, WAY.600, temsirolimus, LY303511, torin.1, GSK2126458, NVP.BEZ235, XL388, AZD8055, MLN0128, sirolimus, GDC.0980, deforolimus, LY3023414, OSI.027, torin.2, PKI.179",0.226945306635737,0.112382699664264,FALSE +"H460","Pearson.est","NFkB pathway inhibitor",0.46289,1.31,0.172,217,0.617,"curcumin, EVP4593, bortezomib, betulinic.acid",0.764471553092451,0.209714835966758,FALSE +"H460","Pearson.est","opioid receptor agonist",0.47023,1.34,0.144,593,0.62,"cebranopadol, salvinorin.a, trimebutine, ADL5859, spiradoline",0.84163750790475,0.207608310501746,FALSE +"H460","Pearson.est","p38 MAPK inhibitor",0.4497,1.29,0.158,646,0.563,"CMPD.1, TAK.715, VX.702, SB.242235, talmapimod",0.801342913045577,0.249491605148654,FALSE +"H460","Pearson.est","PARP inhibitor",0.54724,1.58,0.0492,362,0.707,"AG.14361, PJ.34, olaparib, talazoparib",1.30803489723264,0.150580586203101,FALSE +"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.3893,1.11,0.328,557,0.654,"dasatinib, CP.673451, KI.8751, tandutinib, motesanib, nintedanib, regorafenib, ponatinib, sunitinib, masitinib, SU014813, telatinib",0.484126156288321,0.184422251675733,FALSE +"H460","Pearson.est","phosphatase inhibitor",0.31521,0.917,0.563,190,0.804,"CID.5458317, mycophenolate.mofetil, sodium.stibogluconate",0.249491605148654,0.0947439512515487,FALSE +"H460","Pearson.est","phosphodiesterase inhibitor",0.33836,0.968,0.499,409,0.824,"avanafil, EMD.53998, trequinsin, anagrelide, YM.976",0.30189945437661,0.0840727883028842,FALSE +"H460","Pearson.est","PI3K inhibitor",-0.16395,-0.563,0.95,221,1,"GDC.0941, LY303511, BGT226, GSK2126458, NVP.BEZ235, TG100.115, taselisib, GDC.0980, LY3023414, TG.100713, ZSTK.474, PKI.179, idelalisib, alpelisib, buparlisib, CUDC.907, CH5132799, PI3K.IN.2, SB.2343, voxtalisib, PI.103, pilaralisib, PIK.75, AZD6482, PF.05212384, PF.04691502, YM.201636",0.0222763947111523,0,FALSE +"H460","Pearson.est","PLK inhibitor",-0.54094,-1.82,0.0347,740,0.129,"GW.843682X, GSK461364, rigosertib, volasertib, HMN.214, BI.2536, NMS.1286937",1.45967052520913,0.889410289700751,TRUE +"H460","Pearson.est","potassium channel blocker",0.59864,1.71,0.0225,402,1,"dofetilide, meglitinide, oleoylethanolamide, mepivacaine, ML133",1.64781748188864,0,FALSE +"H460","Pearson.est","progesterone receptor agonist",-0.36735,-1.26,0.196,1295,0.639,"levonorgestrel, nomegestrol.acetate, norethindrone",0.707743928643524,0.1944991418416,FALSE +"H460","Pearson.est","proteasome inhibitor",0.26065,0.754,0.771,683,0.853,"bortezomib, carfilzomib, ixazomib, oprozomib",0.112945621949043,0.069050968832477,FALSE +"H460","Pearson.est","protein synthesis inhibitor",-0.24934,-0.866,0.615,1228,0.873,"clofoctol, harringtonine, homoharringtonine, bruceantin, anguidine, chloramphenicol.palmitate",0.211124884224583,0.0589857562944303,FALSE +"H460","Pearson.est","protein tyrosine kinase inhibitor",0.42007,1.2,0.255,370,0.595,"NVP.TAE226, mubritinib",0.593459819566045,0.22548303427145,FALSE +"H460","Pearson.est","RAF inhibitor",-0.20308,-0.668,0.85,277,1,"vemurafenib, regorafenib, TAK.632, CEP.32496, GDC.0879, AZ.628, sorafenib, LGX818, RAF265, PLX.4720, SB.590885",0.0705810742857073,0,FALSE +"H460","Pearson.est","RET tyrosine kinase inhibitor",0.5534,1.58,0.0465,447,0.707,"apatinib, cabozantinib, regorafenib, sunitinib",1.33254704711005,0.150580586203101,FALSE +"H460","Pearson.est","retinoid receptor agonist",-0.56382,-1.9,0.00571,1308,0.138,"LE.135, AM.580, CD.437",2.24336389175415,0.860120913598763,TRUE +"H460","Pearson.est","ribonucleotide reductase inhibitor",0.23674,0.674,0.861,619,0.899,"triapine, hydroxyurea, gemcitabine, cladribine",0.0649968485463452,0.0462403082667712,FALSE +"H460","Pearson.est","serotonin receptor antagonist",0.38478,1.09,0.347,468,0.675,"paliperidone, lurasidone, tropisetron, RS.16566, lerisetron, SB.228357",0.459670525209126,0.170696227168975,FALSE +"H460","Pearson.est","sodium channel blocker",0.3638,1.04,0.411,365,0.715,"oxcarbazepine, ajmaline, mexiletine, triamterene, butamben, mepivacaine",0.386158178123931,0.145693958198919,FALSE +"H460","Pearson.est","src inhibitor",0.32925,0.944,0.512,799,0.809,"dasatinib, saracatinib, bosutinib, PP.2, masitinib, PP.1, ZM.306416, KX2.391",0.290730039024169,0.0920514783877277,FALSE +"H460","Pearson.est","TGF beta receptor inhibitor",0.50559,1.43,0.104,159,0.591,"LY2109761, repsox, adaprev",0.98296666070122,0.228412519118745,FALSE +"H460","Pearson.est","thymidylate synthase inhibitor",0.50207,1.43,0.0983,633,0.591,"capecitabine, raltitrexed, trifluridine, ftorafur, carmofur",1.00744648216786,0.228412519118745,FALSE +"H460","Pearson.est","topoisomerase inhibitor",0.3109,0.895,0.594,594,0.771,"camptothecin, etoposide, fleroxacin, valrubicin, idarubicin, TAS.103, teniposide, amsacrine, SN.38, voreloxin, genz.644282, amonafide",0.226213555018806,0.112945621949043,FALSE +"H460","Pearson.est","tubulin polymerization inhibitor",-0.32028,-1.06,0.356,639,0.977,"epothilone.d, flubendazole, CYT.997, dolastatin.10, KX2.391, parbendazole, nocodazole, epothilone.b, plinabulin, docetaxel, ABT.751, podophyllotoxin, paclitaxel, combretastatin.A.4, verubulin, BNC105, fosbretabulin, vincristine, albendazole, indibulin, taltobulin, vindesine, vinblastine, vinorelbine, fenbendazole",0.448550002027125,0.0101054362812269,FALSE +"H460","Pearson.est","tyrosine kinase inhibitor",0.40625,1.16,0.281,447,0.592,"dasatinib, apatinib, cabozantinib, AMG.208, UNC2250, NVP.TAE226, mubritinib, regorafenib, sunitinib",0.55129368009492,0.22767829327708,FALSE +"H460","Pearson.est","VEGFR inhibitor",0.3012,0.862,0.62,447,0.776,"cabozantinib, tivozanib, ENMD.2076, MK.2461, foretinib, KI.8751, PD.173074, OSI.930, XL.647, motesanib, nintedanib, regorafenib, MGCD.265, sunitinib",0.207608310501746,0.110138278741812,FALSE +"H460","Pearson.est","vitamin D receptor agonist",0.44152,1.25,0.194,771,0.592,"tacalcitol, maxacalcitol, alfacalcidol, ercalcitriol, paricalcitol, doxercalciferol, calcitriol",0.712198270069774,0.22767829327708,FALSE +"H520","Pearson.est","EGFR inhibitor",0.50425,1.36,0.15,434,0.392,"WZ.3146, lapatinib, tucatinib, tyrphostin.AG.494, osimertinib, brigatinib, WZ8040, CGP.52411, PD.168393, BMS.599626, pelitinib, icotinib, CUDC.101, XL.647, poziotinib, canertinib, PD.153035, AZD8931, erlotinib, gefitinib, vandetanib, dacomitinib",0.823908740944319,0.406713932979543,FALSE +"H520","Pearson.est","Abl kinase inhibitor",-0.25796,-0.706,0.816,1216,0.99,"KW.2449, GZD824, tozasertib",0.0883098412461389,0.00436480540245009,FALSE +"H520","Pearson.est","acetylcholine receptor agonist",0.34805,0.963,0.478,146,0.719,"nicotine, nefiracetam",0.320572103387881,0.143271109617117,FALSE +"H520","Pearson.est","acetylcholine receptor antagonist",0.64941,1.77,0.0371,507,0.202,"dicycloverine, iododexetimide, darifenacin, diphemanil, hyoscyamine, methscopolamine",1.43062609038495,0.694648630553376,TRUE +"H520","Pearson.est","adenosine receptor antagonist",0.64709,1.78,0.0147,479,0.232,"CGS.15943, MRS.1220, theophylline, PSB.1115, sulmazole, istradefylline",1.83268266525182,0.6345120151091,TRUE +"H520","Pearson.est","adrenergic receptor agonist",0.52221,1.44,0.118,244,0.318,"isoxsuprine, isoetharine, methyldopa, metaraminol, buphenine, terbutaline, ritodrine",0.928117992693875,0.497572880015567,FALSE +"H520","Pearson.est","adrenergic receptor antagonist",0.3148,0.864,0.607,283,0.779,"atenolol...., prazosin, imiloxan, RS.17053, metoprolol, pindolol",0.216811308924742,0.108462542327436,FALSE +"H520","Pearson.est","AKT inhibitor",0.40578,1.07,0.391,412,0.671,"GSK2110183, AT7867, GDC.0068, palomid.529, AZD5363, CCT128930",0.407823242604133,0.173277479831008,FALSE +"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27958,-0.747,0.764,1141,1,"SB.505124, NVP.TAE684, lorlatinib",0.11690664142431,0,FALSE +"H520","Pearson.est","androgen receptor antagonist",0.662,1.78,0.0271,418,0.232,"RU.58841, cyproterone.acetate, enzalutamide, flutamide, nilutamide",1.56703070912559,0.6345120151091,TRUE +"H520","Pearson.est","antioxidant",-0.3454,-0.934,0.521,1262,0.85,"mesna, chlorogenic.acid",0.283162276700476,0.0705810742857073,FALSE +"H520","Pearson.est","AP inhibitor",0.54622,1.45,0.127,361,0.326,"embelin, tanshinone.i, idronoxil, GDC.0152",0.896196279044043,0.486782399932061,FALSE +"H520","Pearson.est","ATPase inhibitor",-0.31517,-0.845,0.63,1074,0.906,"evodiamine, digoxin, thonzonium, NMS.873",0.200659450546418,0.0428718023231869,FALSE +"H520","Pearson.est","Aurora kinase inhibitor",-0.62188,-1.65,0.0468,1088,0.25,"MK.8745, TAK.901, alisertib, CCT129202, CCT137690, KW.2449, MK.5108, PHA.680632, PF.03814735, aurora.a.inhibitor.i, danusertib, GSK1070916, hesperadin, tozasertib, MLN.8054, barasertib",1.32975414692588,0.602059991327962,FALSE +"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.54204,-1.44,0.114,1042,0.305,"radezolid, azalomycin.b, tedizolid, azithromycin, valnemulin",0.943095148663527,0.515700160653214,FALSE +"H520","Pearson.est","bacterial DNA gyrase inhibitor",-0.25104,-0.681,0.831,1225,0.989,"novobiocin, trovafloxacin",0.080398976215889,0.0048037084028206,FALSE +"H520","Pearson.est","BCL inhibitor",0.2426,0.665,0.877,39,0.981,"gossypol",0.0570004066339595,0.0083309926200515,FALSE +"H520","Pearson.est","Bcr.Abl kinase inhibitor",-0.27086,-0.746,0.769,1290,1,"GZD824, tozasertib",0.114073660198569,0,FALSE +"H520","Pearson.est","benzodiazepine receptor agonist",0.38213,1.06,0.354,229,0.663,"CL.218872, nefiracetam, gamma.aminobutyric.acid, ivermectin",0.450996737974212,0.178486471595227,FALSE +"H520","Pearson.est","bromodomain inhibitor",-0.76421,-2,0.00205,1235,0.0479,"OTX015, PFI.1, I.BET151, I.BET.762",2.68824613894425,1.31966448658544,TRUE +"H520","Pearson.est","calcium channel blocker",0.21404,0.577,0.94,1130,0.979,"mibefradil, cinnarazine, efonidipine.monoethanolate, pranidipine, SR.33805, SKF.96365, fendiline, penfluridol, tetrandrine, carboxyamidotriazole",0.0268721464003014,0.00921730819686218,FALSE +"H520","Pearson.est","CC chemokine receptor antagonist",-0.48319,-1.33,0.158,1057,0.387,"ZK811752, PF.04136309, SB.225002, MK.0812",0.801342913045577,0.412289034981089,FALSE +"H520","Pearson.est","CDK inhibitor",-0.4988,-1.34,0.154,1351,0.403,"PHA.793887, R547, indisulam, BMS.265246, AZD5438",0.812479279163537,0.39469495385889,FALSE +"H520","Pearson.est","CHK inhibitor",0.53642,1.47,0.0936,24,0.325,"SCH.900776",1.02872415126189,0.488116639021126,FALSE +"H520","Pearson.est","cyclooxygenase inhibitor",-0.15828,-0.423,0.99,1244,0.996,"indoprofen, sulfasalazine, AM.404",0.00436480540245009,0.00174066157630127,FALSE +"H520","Pearson.est","cytochrome P450 inhibitor",0.5525,1.48,0.0982,362,0.335,"clotrimazole, eplerenone, morin, metyrapone, cobicistat",1.00788851221305,0.474955192963155,FALSE +"H520","Pearson.est","DNA alkylating agent",-0.21496,-0.579,0.926,1238,0.965,"mitomycin.c, carmustine",0.0333890133180656,0.0154726866562074,FALSE +"H520","Pearson.est","DNA inhibitor",-0.2491,-0.665,0.845,876,0.942,"teroxirone, mechlorethamine, busulfan, carboplatin, oxaliplatin, valrubicin, sangivamycin, carmustine",0.0731432910503077,0.0259490972071227,FALSE +"H520","Pearson.est","DNA methyltransferase inhibitor",-0.26032,-0.708,0.793,944,1,"azacitidine, decitabine, disulfiram, SGI.1027",0.100726812682396,0,FALSE +"H520","Pearson.est","DNA polymerase inhibitor",-0.34041,-0.904,0.525,1077,0.83,"foscarnet, idoxuridine, cephalomannine, cidofovir",0.279840696594043,0.0809219076239261,FALSE +"H520","Pearson.est","DNA synthesis inhibitor",-0.40324,-1.08,0.356,1238,0.643,"mitomycin.c, enocitabine, anisomycin, capecitabine",0.448550002027125,0.191789027075778,FALSE +"H520","Pearson.est","dopamine receptor antagonist",0.32001,0.878,0.595,513,0.8,"ziprasidone, remoxipride, piperacetazine, sertindole, clebopride, lurasidone, mesoridazine, UH.232...., nemonapride, isofloxythepin",0.22548303427145,0.0969100130080564,FALSE +"H520","Pearson.est","estrogen receptor agonist",0.42255,1.14,0.289,15,0.575,"levonorgestrel",0.539102157243452,0.24033215531037,FALSE +"H520","Pearson.est","estrogen receptor antagonist",0.374,1.03,0.411,336,0.644,"clomifene, tamoxifen, raloxifene",0.386158178123931,0.191114132640188,FALSE +"H520","Pearson.est","FGFR inhibitor",0.43655,1.19,0.239,384,0.52,"lucitanib, PD.173074, orantinib, regorafenib, erdafitinib",0.621602099051862,0.283996656365201,FALSE +"H520","Pearson.est","FLT3 inhibitor",0.24132,0.653,0.868,140,0.973,"tandutinib, GTP.14564, midostaurin",0.0614802748235081,0.0118871597316481,FALSE +"H520","Pearson.est","glucocorticoid receptor agonist",-0.48744,-1.31,0.183,1002,0.386,"fludroxycortide, fluticasone.propionate, triamcinolone.acetonide, deflazacort, clobetasol.propionate, flumethasone.pivalate, betamethasone, halcinonide, halobetasol.propionate, beclomethasone.dipropionate, rimexolone, fluorometholone",0.737548910269571,0.413412695328245,FALSE +"H520","Pearson.est","glutamate receptor antagonist",0.44626,1.21,0.247,224,0.512,"SIB.1757, ACDPP, JNJ.16259685, kynurenic.acid, diazooxonorleucine",0.607303046740334,0.290730039024169,FALSE +"H520","Pearson.est","glycogen synthase kinase inhibitor",0.6047,1.65,0.0402,97,0.288,"TWS.119, indirubin, GSK.3.inhibitor.IX",1.39577394691553,0.540607512240769,FALSE +"H520","Pearson.est","growth factor receptor inhibitor",0.33456,0.901,0.541,135,0.784,"GW.441756, GSK1838705A",0.266802734893431,0.105683937315562,FALSE +"H520","Pearson.est","HDAC inhibitor",-0.61829,-1.64,0.0451,1105,0.225,"vorinostat, ACY.1215, entinostat, NSC.3852, resminostat, chidamide, PCI.24781, panobinostat, scriptaid, belinostat, SB.939, trichostatin.a, AR.42, givinostat, JNJ.26481585, romidepsin, dacinostat, M.344",1.34582345812204,0.647817481888638,TRUE +"H520","Pearson.est","histamine receptor antagonist",0.2337,0.633,0.861,118,0.973,"terfenadine, chloropyramine, famotidine",0.0649968485463452,0.0118871597316481,FALSE +"H520","Pearson.est","HSP inhibitor",-0.68719,-1.85,0.00967,1224,0.111,"alvespimycin, PU.H71, ganetespib, KW.2478, BIIB021, NMS.E973, VER.49009, tanespimycin, SNX.2112",2.014573525917,0.954677021213343,TRUE +"H520","Pearson.est","JAK inhibitor",0.32204,0.86,0.619,233,0.765,"baricitinib, atiprimod, AT.9283, ruxolitinib, LY2784544",0.208309350979882,0.116338564846382,FALSE +"H520","Pearson.est","KIT inhibitor",0.35763,0.96,0.498,205,0.702,"tandutinib, dasatinib, midostaurin, masitinib, telatinib, imatinib",0.302770657240282,0.153662887870195,FALSE +"H520","Pearson.est","MDM inhibitor",0.58642,1.58,0.0621,597,0.314,"AMG.232, RITA, CGM097, idasanutlin, nutlin.3, serdemetan",1.20690839982342,0.503070351926785,FALSE +"H520","Pearson.est","MEK inhibitor",-0.59363,-1.56,0.0711,1277,0.285,"PD.98059, PD.318088, PD.184352, PD.0325901, TAK.733, AZD8330, MEK162, Ro.4987655, refametinib, PD.198306",1.14813039927023,0.54515513999149,FALSE +"H520","Pearson.est","MET inhibitor",0.64528,1.78,0.0264,435,0.232,"NVP.BVU972, PF.04217903, INC.280, LY2801653, PHA.665752",1.57839607313017,0.6345120151091,TRUE +"H520","Pearson.est","microtubule inhibitor",0.2976,0.822,0.656,212,0.789,"colchicine, estramustine.phosphate, secnidazole",0.18309616062434,0.10292299679058,FALSE +"H520","Pearson.est","mTOR inhibitor",0.57334,1.54,0.0795,471,0.285,"torin.1, PI.103, SB.2343, sirolimus, LY3023414, deforolimus, torin.2, WAY.600, OSI.027, PF.04691502, everolimus, ku.0063794, temsirolimus, palomid.529, WYE.125132, AZD8055, NVP.BEZ235, PP242, GDC.0980",1.09963287134353,0.54515513999149,FALSE +"H520","Pearson.est","NFkB pathway inhibitor",-0.34911,-0.913,0.514,1102,0.852,"BAY.11.7085, Ro.106.9920, parthenolide...., EVP4593",0.289036881004724,0.0695604052332999,FALSE +"H520","Pearson.est","opioid receptor agonist",0.3898,1.04,0.404,332,0.649,"cebranopadol, ADL5859, trimebutine",0.393618634889395,0.187755303199631,FALSE +"H520","Pearson.est","p38 MAPK inhibitor",0.64458,1.74,0.0333,437,0.205,"SB.242235, TAK.715, SB.239063, skepinone.l, VX.702",1.47755576649368,0.688246138944246,TRUE +"H520","Pearson.est","PARP inhibitor",-0.43612,-1.15,0.298,1099,0.59,"endo.IWR.1, AG.14361, talazoparib, olaparib",0.525783735923745,0.229147988357856,FALSE +"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.32762,0.873,0.604,280,0.787,"tandutinib, dasatinib, SU014813, masitinib, telatinib, imatinib, orantinib, regorafenib",0.218963061378868,0.104025267640935,FALSE +"H520","Pearson.est","phosphatase inhibitor",0.56727,1.56,0.0693,407,0.284,"menadione, AS.1949490, mycophenolic.acid, BVT.948, mycophenolate.mofetil, alexidine",1.15926676538819,0.546681659952962,FALSE +"H520","Pearson.est","phosphodiesterase inhibitor",0.4956,1.33,0.154,318,0.409,"GSK256066, avanafil, enoximone, cilostamide",0.812479279163537,0.388276691992658,FALSE +"H520","Pearson.est","PI3K inhibitor",0.30378,0.824,0.649,167,0.806,"PI.103, SB.2343, TG100.115, LY3023414, PF.04691502",0.187755303199631,0.0936649581949093,FALSE +"H520","Pearson.est","PLK inhibitor",-0.86557,-2.32,0,1289,0.00476,"volasertib, NMS.1286937, GW.843682X, GSK461364, rigosertib, BI.2536",Inf,2.32239304727951,TRUE +"H520","Pearson.est","potassium channel blocker",-0.55153,-1.47,0.101,1411,0.3,"dofetilide",0.995678626217357,0.522878745280338,FALSE +"H520","Pearson.est","PPAR receptor agonist",0.60406,1.59,0.0598,156,0.336,"pterostilbene, S26948, GW.501516",1.22329881601159,0.473660722610156,FALSE +"H520","Pearson.est","progesterone receptor agonist",0.68736,1.87,0.00982,26,0.673,"norethindrone.acetate, levonorgestrel, nomegestrol.acetate",2.00788851221305,0.171984935776023,FALSE +"H520","Pearson.est","proteasome inhibitor",-0.75661,-2.01,0.00397,1108,0.0658,"oprozomib, delanzomib, ixazomib, ONX.0914, carfilzomib",2.40120949323688,1.18177410638604,TRUE +"H520","Pearson.est","protein synthesis inhibitor",-0.41425,-1.11,0.307,1109,0.624,"anguidine, thiostrepton, harringtonine, puromycin, azomycin..2.nitroimidazole., cycloheximide, bruceantin, tedizolid.phosphate",0.512861624522813,0.204815410317576,FALSE +"H520","Pearson.est","protein tyrosine kinase inhibitor",0.22801,0.616,0.895,210,0.967,"mubritinib, BMS.599626",0.048176964684088,0.0145735259169983,FALSE +"H520","Pearson.est","RAF inhibitor",-0.57183,-1.53,0.0765,967,0.259,"AZ.628, GDC.0879, vemurafenib, dabrafenib, RAF265, SB.590885, PLX.4720, CEP.32496, TAK.632, sorafenib",1.11633856484638,0.586700235918748,FALSE +"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.38152,-1.02,0.433,1420,0.716,"sorafenib",0.363512103646635,0.145086977692144,FALSE +"H520","Pearson.est","retinoid receptor agonist",0.28575,0.788,0.708,441,0.824,"fenretinide, CD.437, bexarotene, tamibarotene",0.149966742310231,0.0840727883028842,FALSE +"H520","Pearson.est","ribonucleotide reductase inhibitor",0.45577,1.23,0.222,402,0.505,"triapine, cladribine, cytarabine, pentostatin, gemcitabine",0.653647025549361,0.296708621881339,FALSE +"H520","Pearson.est","serotonin receptor antagonist",-0.25005,-0.671,0.848,1089,0.968,"SB.228357, pirenperone, SB.200646, paliperidone, tropisetron",0.0716041477432862,0.0141246426916063,FALSE +"H520","Pearson.est","sodium channel blocker",0.20745,0.569,0.941,1140,0.963,"A.803467, benzocaine, oxcarbazepine, ajmaline, cibenzoline, brivaracetam, butamben, quinidine, triamterene, mepivacaine, lappaconite, mexiletine, benzethonium",0.0264103765727431,0.0163737128754655,FALSE +"H520","Pearson.est","src inhibitor",0.59563,1.57,0.0708,185,0.297,"dasatinib, saracatinib, masitinib, PP.2",1.14996674231023,0.527243550682788,FALSE +"H520","Pearson.est","sterol demethylase inhibitor",0.49154,1.31,0.172,460,0.412,"terconazole, posaconazole, sulconazole, lanoconazole",0.764471553092451,0.385102783966865,FALSE +"H520","Pearson.est","TGF beta receptor inhibitor",0.69526,1.86,0.00826,154,0.361,"SB.525334, LY2109761",2.08301995267962,0.442492798094342,FALSE +"H520","Pearson.est","thymidylate synthase inhibitor",0.37096,0.998,0.439,172,0.68,"ftorafur, doxifluridine",0.357535479757879,0.167491087293764,FALSE +"H520","Pearson.est","topoisomerase inhibitor",-0.66722,-1.83,0.00774,1018,0.1,"amonafide, licochalcone.a, etoposide.phosphate, valrubicin, voreloxin, nemorubicin, teniposide, genz.644282, etoposide, epirubicin, TAS.103, irinotecan, camptothecin, daunorubicin, rubitecan, amsacrine, idarubicin, mitoxantrone, doxorubicin, topotecan, dexrazoxane",2.11125903931711,1,TRUE +"H520","Pearson.est","tubulin polymerization inhibitor",-0.5495,-1.53,0.0877,997,0.259,"KX2.391, plinabulin, BNC105, ABT.751, taltobulin, vinblastine, dolastatin.10, combretastatin.A.4, parbendazole, vincristine, epothilone.b, vindesine, vinorelbine, fosbretabulin, docetaxel, paclitaxel, fenbendazole",1.05700040663396,0.586700235918748,FALSE +"H520","Pearson.est","tyrosine kinase inhibitor",-0.22073,-0.594,0.929,1350,0.984,"tivantinib, PP.121, sorafenib",0.0319842860063582,0.00700490156865849,FALSE +"H520","Pearson.est","VEGFR inhibitor",0.1907,0.508,0.98,485,0.975,"lucitanib, SU014813, PD.173074, telatinib, foretinib, semaxanib, orantinib, regorafenib, XL.647, golvatinib, linifanib, SAR131675, vandetanib, KI.8751, sunitinib, BMS.690514",0.00877392430750515,0.0109953843014632,FALSE +"H520","Pearson.est","vitamin D receptor agonist",0.38851,1.04,0.384,627,0.649,"doxercalciferol, ercalcitriol, maxacalcitol, tacalcitol, alfacalcidol, paricalcitol",0.415668775632469,0.187755303199631,FALSE diff --git a/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_venn_diagram.pdf b/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_venn_diagram.pdf new file mode 100644 index 0000000000000000000000000000000000000000..7464b0d832b644be9b502dfa3fb4b588448b931a GIT binary patch literal 7604 zcmZ{pbzGBs`^V`RC@CQ|P&&rQO+t`VxqYo8v#SRAU#xJXarC|^_qmZgp@cKEDMH;gC)U&0FVyS;eWm}c0s%0y$pdG z-Y`#R7dQ&2he3N{(0Dg}Z=?eTj_^KzD48~qz`jKpn#Hi14H0{9Ay9HaBg>Q?Tzq2|7i|VL3*I^M-&k9%N=Bh 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+
+
+ + + + diff --git a/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_mean_results.csv b/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..8d70ace --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"estrogen receptor antagonist",1.00241666666667,0.696588891192885,0.124327712710528,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.265331768848105 +"RAF inhibitor",0.698,1.13162080060577,0.0047006947780887,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.0278684047558116 +"MEK inhibitor",0.667833333333333,1.60164357817685,5.08540197049992e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"H1650, H520, H460, H1299, H1703",0.000844176727102987 +"retinoid receptor agonist",0.610333333333333,1.03738520357968,0.171997633009449,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.339900084280579 +"HMGCR inhibitor",0.5195,1.9209607681385,8.5331314142516e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,7,"HCC95, H1975, H1648, H2126, H1299, HCC44, H1703",0.000395749475218249 +"MDM inhibitor",0.45425,1.52040958147946,0.00416580339781743,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1650, HCC95, H1648, H460",0.0265970524629882 +"glutamate receptor antagonist",0.43275,0.716226237111761,0.987358742586612,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"BCL inhibitor",0.425416666666667,1.05488159252232,0.304199929869937,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.515277432228669 +"dopamine receptor antagonist",0.4205,0.89417046371585,0.875993102824703,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"RET tyrosine kinase inhibitor",0.406416666666667,1.0790967989551,0.291163973828253,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.50697819475302 +"phosphatase inhibitor",0.393166666666667,0.983230744520175,0.513890846378439,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.804772457536046 +"thymidylate synthase inhibitor",0.353416666666667,1.40048059662216,4.67424917816275e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1650, H2126, HCC44",0.000844176727102987 +"FGFR inhibitor",0.32725,1.13192427669956,0.176518018039236,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.340720825517595 +"benzodiazepine receptor agonist",0.32275,0.573400562037965,0.999999744255947,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"Bcr.Abl kinase inhibitor",0.311416666666667,1.25046772764386,0.0259847661335041,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.0937711125687321 +"antioxidant",0.2925,1.39479633573573,0.0129712791125946,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.0616112951911576 +"Abl kinase inhibitor",0.2875,1.24619431579801,0.041043726324705,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.121665331605376 +"acetylcholine receptor agonist",0.236583333333333,0.981314559736844,0.770707396593526,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"cytochrome P450 inhibitor",0.232083333333333,1.30142770960716,0.0150124187360823,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.0655805660576229 +"proteasome inhibitor",0.221916666666667,1.25182531879966,0.0251527702555807,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0937711125687321 +"CC chemokine receptor antagonist",0.215916666666667,1.30495743283647,0.00678708773166565,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.0375552187818833 +"p38 MAPK inhibitor",0.213916666666667,1.20391123640886,0.094665808369185,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.218257280406732 +"adenosine receptor antagonist",0.185,1.38904735176831,0.00218259813041714,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H2126, H1299, H1703",0.0164686949840566 +"TGF beta receptor inhibitor",0.164,1.2726662063272,0.0381301100288775,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.117214782681364 +"adrenergic receptor agonist",0.142583333333333,0.841425031320874,0.992401426537453,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"FLT3 inhibitor",0.13425,1.09332463157106,0.410067230754878,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.667364316718723 +"bacterial DNA gyrase inhibitor",0.13425,1.03675017811341,0.684040247241143,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.946255675350247 +"HCV inhibitor",0.126916666666667,1.05333370852506,0.633163264300218,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646 +"sterol demethylase inhibitor",0.125583333333333,0.99504037911062,0.792730624396318,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"histamine receptor antagonist",0.113166666666667,0.67722251390022,0.999997961805646,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"growth factor receptor inhibitor",0.10475,1.26224044136535,0.0379479136146386,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.117214782681364 +"ALK tyrosine kinase receptor inhibitor",0.0668333333333333,1.01703542740952,0.741185677459224,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.999999744255948 +"EGFR inhibitor",0.058,1.84339055201895,3.20369112697271e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,7,"HCC95, H1975, H1648, H2126, H520, H1299, H1703",0.000844176727102987 +"mTOR inhibitor",0.0465833333333333,1.05096738625406,0.614580823363627,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646 +"glycogen synthase kinase inhibitor",0.0435,0.980106534098114,0.998823553215968,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.999999744255948 +"bromodomain inhibitor",0.04025,1.53547914493993,0.0340763504946138,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, A549",0.113133483642118 +"glucocorticoid receptor agonist",0.0339166666666667,1.29597309584401,0.0158476448165722,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0657677259887745 +"src inhibitor",0.0273333333333334,1.50636403503954,8.24951913546827e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"HCC95, H520, H1299, HCC44, H1703",0.00114118348040644 +"KIT inhibitor",0.0248333333333333,0.94747125965846,0.935832669479616,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"HDAC inhibitor",0.0211666666666666,1.1537745039914,0.293192209013795,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, A549",0.50697819475302 +"acetylcholine receptor antagonist",-0.00183333333333337,1.23950597441322,0.0779561053013444,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.200456681429326 +"estrogen receptor agonist",-0.00725000000000005,0.801671336532735,0.999452080686153,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"DNA inhibitor",-0.00916666666666668,0.931550694793202,0.966638581217711,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"progesterone receptor agonist",-0.0171666666666666,1.09721745862666,0.46373187184175,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.740187410824331 +"PI3K inhibitor",-0.0253333333333333,1.06693608339985,0.608568603424358,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646 +"tyrosine kinase inhibitor",-0.02975,1.00830380748156,0.811127303266585,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"DNA polymerase inhibitor",-0.0300833333333334,1.04827507305472,0.588924130380289,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646 +"DNA methyltransferase inhibitor",-0.0356666666666666,1.13077329400028,0.283229556884785,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.50697819475302 +"ribonucleotide reductase inhibitor",-0.0415000000000001,1.28968385837206,0.0329390189674143,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.113133483642118 +"opioid receptor agonist",-0.0475833333333333,1.23267303475255,0.0933508384303763,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.218257280406732 +"AP inhibitor",-0.0699166666666666,1.33192556837722,0.101268730435768,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1975, A549",0.227170395301859 +"PPAR receptor agonist",-0.0780833333333334,1.27135793245814,0.0627046999800293,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.167886777365885 +"NFkB pathway inhibitor",-0.0893333333333333,0.704062669386925,0.99998542119808,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"JAK inhibitor",-0.0970833333333334,1.01858515583969,0.812129700429645,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"AKT inhibitor",-0.119916666666667,1.24744243505978,0.0796996444237081,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H2126",0.200456681429326 +"phosphodiesterase inhibitor",-0.125833333333333,0.938912313974704,0.926782184949637,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"PDGFR tyrosine kinase receptor inhibitor",-0.1285,1.00276857658276,0.762426676890818,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"protein tyrosine kinase inhibitor",-0.166416666666667,1.3955663860522,0.000996752902459099,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H1648, H2126",0.0103413113630132 +"CDK inhibitor",-0.201916666666667,1.16107743523249,0.0941930017532901,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.218257280406732 +"CHK inhibitor",-0.209583333333333,1.18310919025279,0.204180911811555,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.385159447280888 +"protein synthesis inhibitor",-0.248833333333333,1.17580137726909,0.140001294478339,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.290502686042554 +"serotonin receptor antagonist",-0.263916666666667,1.03078244405388,0.624882064154891,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646 +"VEGFR inhibitor",-0.2715,0.741741868846568,0.999534634664959,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"calcium channel blocker",-0.27525,0.937528775315966,0.866095767459057,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"adrenergic receptor antagonist",-0.275916666666667,0.770525494632584,0.998631425519013,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"androgen receptor antagonist",-0.29825,1.28566609018615,0.0133614857041065,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, A549, HCC15",0.0616112951911576 +"bacterial 50S ribosomal subunit inhibitor",-0.31975,0.987198158702423,0.630216737456706,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646 +"Aurora kinase inhibitor",-0.37975,1.24472122654761,0.0085197872386698,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0441963963005996 +"PARP inhibitor",-0.394416666666667,1.1955539954601,0.044614158385556,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.127688798137971 +"DNA alkylating agent",-0.401166666666667,0.901674486046865,0.846215198379105,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"potassium channel blocker",-0.408,1.0340825534128,0.399605399146996,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.663344962584014 +"sodium channel blocker",-0.409833333333333,0.682226013380708,0.998626395757675,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"DNA synthesis inhibitor",-0.438166666666667,1.10393995499865,0.226980227883247,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.41865242031799 +"vitamin D receptor agonist",-0.442416666666667,1.55978701683236,0.0206707016748029,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1648, H2126, H1299",0.08169848757184 +"MET inhibitor",-0.4645,1.14146233960095,0.165128270570095,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.334284059934583 +"cyclooxygenase inhibitor",-0.46875,0.609628370402822,0.999158830773346,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"tubulin polymerization inhibitor",-0.49775,1.28656894844035,0.00133279142519831,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H2126, H1299",0.012291298699051 +"PLK inhibitor",-0.596666666666667,1.47931392779548,9.53613193296986e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H460, H1299",0.000395749475218249 +"microtubule inhibitor",-0.613833333333333,1.17771124978867,0.00249951164829279,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H2126, H460, H1299",0.0172882889006918 +"topoisomerase inhibitor",-0.66875,1.22133058029497,0.00183574463749805,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1299, H1703",0.0152366804912338 +"ATPase inhibitor",-0.752666666666667,1.00384717537838,0.0468005257141872,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1299",0.129481454475918 +"serotonin receptor agonist",-0.81,1.27959148310559,0.00014168317666895,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1975",0.00167995766621755 +"HSP inhibitor",-0.958416666666667,0.69444293676604,0.124673963675616,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.265331768848105 diff --git a/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_results.csv b/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_results.csv new file mode 100644 index 0000000..6cd3803 --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_results.csv @@ -0,0 +1,997 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"H1650","Pearson.est","EGFR inhibitor",-0.18808,-0.582,0.967,1165,0.95,"AZD8931, TAK.285, FERb.033, WZ8040, icotinib, WZ.3146, BMS.599626, neratinib, rociletinib, ARRY.334543, CP.724714, lapatinib, osimertinib, PD.168393, GW.583340, brigatinib, canertinib, BMS.690514, tucatinib",0.0145735259169983,0.0222763947111523,FALSE +"H1650","Pearson.est","Abl kinase inhibitor",0.54126,1.27,0.168,427,0.685,"KW.2449, GZD824, tozasertib, bafetinib, ponatinib, nilotinib, flumatinib",0.774690718274137,0.164309428507574,FALSE +"H1650","Pearson.est","acetylcholine receptor agonist",0.55053,1.31,0.143,550,0.745,"oxiracetam, tremorine, pilocarpine, xanomeline, nicotine",0.844663962534938,0.127843727251707,FALSE +"H1650","Pearson.est","acetylcholine receptor antagonist",-0.52982,-1.61,0.0464,764,0.393,"hyoscyamine, iododexetimide, dicycloverine, diphemanil, methscopolamine, darifenacin",1.33348201944512,0.405607449624573,FALSE +"H1650","Pearson.est","adenosine receptor antagonist",0.45164,1.08,0.365,328,0.885,"istradefylline, sulmazole, PSB.1115, SCH.58261",0.437707135543525,0.0530567293021746,FALSE +"H1650","Pearson.est","adrenergic receptor agonist",-0.19853,-0.624,0.915,1447,0.978,"xylazine",0.0385789059335517,0.00966114521239857,FALSE +"H1650","Pearson.est","adrenergic receptor antagonist",0.34548,0.829,0.694,317,1,"oxprenolol, carvedilol, atipamezole, atenolol......, idazoxan",0.158640529545145,0,FALSE +"H1650","Pearson.est","AKT inhibitor",-0.31037,-0.9,0.587,446,0.645,"palomid.529, ONC201, uprosertib, AT7867, AZD5363, MK.2206, triciribine, GSK2110183, CCT128930, A.674563, GDC.0068",0.231361898752386,0.190440285364732,FALSE +"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.39974,0.947,0.545,510,0.988,"AZD3463, alectinib, DMH1, lorlatinib, CEP.37440",0.263603497723358,0.00524305541237188,FALSE +"H1650","Pearson.est","androgen receptor antagonist",-0.35563,-1.06,0.35,1234,0.475,"enzalutamide, flutamide, RU.58841",0.455931955649724,0.323306390375133,FALSE +"H1650","Pearson.est","antioxidant",0.45589,1.07,0.398,231,0.854,"mesna, trolox",0.400116927926312,0.068542129310995,FALSE +"H1650","Pearson.est","AP inhibitor",-0.45002,-1.36,0.109,1216,0.526,"LCL.161, tanshinone.i, birinapant, GDC.0152",0.962573502059376,0.279014255846261,FALSE +"H1650","Pearson.est","ATPase inhibitor",-0.44453,-1.42,0.109,1318,0.559,"rabeprazole, digitoxigenin, oligomycin.a, omeprazole, k.strophanthidin",0.962573502059376,0.252588192113577,FALSE +"H1650","Pearson.est","Aurora kinase inhibitor",0.56442,1.33,0.124,533,0.729,"GSK1070916, SNS.314, KW.2449, tozasertib, AT.9283, danusertib, hesperadin, alisertib, CCT129202, AMG900, barasertib, barasertib.HQPA, ENMD.2076, CCT137690, PHA.680632, PF.03814735, MK.8745, MK.5108",0.906578314837765,0.137272471682025,FALSE +"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.30728,0.734,0.824,684,1,"valnemulin, tedizolid, tilmicosin, azalomycin.b, azithromycin",0.0840727883028842,0,FALSE +"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.53356,1.27,0.178,146,0.685,"finafloxacin, novobiocin",0.749579997691106,0.164309428507574,FALSE +"H1650","Pearson.est","BCL inhibitor",0.51208,1.23,0.202,224,0.693,"gossypol, TW.37, obatoclax",0.694648630553376,0.159266765388193,FALSE +"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.51671,1.23,0.209,427,0.693,"GZD824, tozasertib, bafetinib, ponatinib, nilotinib, flumatinib",0.679853713888946,0.159266765388193,FALSE +"H1650","Pearson.est","benzodiazepine receptor agonist",0.17413,0.42,0.991,706,0.995,"zaleplon, ZK.93423, lorazepam, ivermectin, eprinomectin, temazepam",0.00392634551472468,0.00217691925427455,FALSE +"H1650","Pearson.est","bromodomain inhibitor",0.49653,1.21,0.228,732,0.686,"bromosporine, I.BET.762, JQ1...., PFI.1, I.BET151, OTX015",0.642065152999546,0.163675884293248,FALSE +"H1650","Pearson.est","calcium channel blocker",0.33933,0.813,0.723,342,1,"tetrandrine, cinnarazine, mibefradil",0.140861702705469,0,FALSE +"H1650","Pearson.est","CC chemokine receptor antagonist",0.70818,1.69,0.0131,233,0.17,"navarixin, ZK811752, PF.04136309, SB.225002",1.88272870434424,0.769551078621726,TRUE +"H1650","Pearson.est","CDK inhibitor",0.69186,1.64,0.0126,248,0.214,"palbociclib, AZD5438, ribociclib, indisulam, abemaciclib, alvocidib, PHA.848125, JNJ.7706621, TG.02, aminopurvalanol.a, dinaciclib, P276.00",1.89962945488244,0.669586226650809,TRUE +"H1650","Pearson.est","CHK inhibitor",-0.43234,-1.3,0.196,623,0.514,"SB.218078, AZD7762, CHIR.124, LY2606368, SCH.900776, LY2603618, PF.477736",0.707743928643524,0.289036881004724,FALSE +"H1650","Pearson.est","cyclooxygenase inhibitor",0.2703,0.644,0.904,453,1,"tepoxalin, meloxicam, FR.122047, ketoprofen, curcumin, aspirin, piroxicam, indoprofen",0.0438315695246367,0,FALSE +"H1650","Pearson.est","cytochrome P450 inhibitor",0.44419,1.05,0.399,486,0.854,"morin, itraconazole, cobicistat",0.399027104313252,0.068542129310995,FALSE +"H1650","Pearson.est","DNA alkylating agent",0.43944,1.04,0.411,482,0.854,"carmustine, melphalan, cyclophosphamide, carboplatin, temozolomide, TH.302, streptozotocin",0.386158178123931,0.068542129310995,FALSE +"H1650","Pearson.est","DNA inhibitor",0.39707,0.941,0.549,395,0.976,"carmustine, oxaliplatin, melphalan, carboplatin, mechlorethamine, sangivamycin, bendamustine",0.260427655549908,0.0105501823333082,FALSE +"H1650","Pearson.est","DNA methyltransferase inhibitor",0.27229,0.654,0.901,653,1,"fdcyd, disulfiram, decitabine, RG108",0.045275209020937,0,FALSE +"H1650","Pearson.est","DNA polymerase inhibitor",0.47391,1.13,0.323,457,0.77,"idoxuridine, trifluridine, adefovir.dipivoxil, foscarnet, famciclovir",0.490797477668897,0.113509274827518,FALSE +"H1650","Pearson.est","DNA synthesis inhibitor",0.44794,1.07,0.392,226,0.854,"anisomycin, floxuridine, cyclocytidine, CB.10.277",0.406713932979543,0.068542129310995,FALSE +"H1650","Pearson.est","dopamine receptor antagonist",0.46674,1.13,0.311,280,0.77,"domperidone, amisulpride, UH.232...., sertindole, paliperidone, isofloxythepin, mesoridazine",0.507239610973163,0.113509274827518,FALSE +"H1650","Pearson.est","estrogen receptor agonist",0.30122,0.715,0.842,481,1,"PPT, estrone, erteberel, ethinyl.estradiol",0.0746879085003505,0,FALSE +"H1650","Pearson.est","estrogen receptor antagonist",0.52217,1.22,0.218,456,0.689,"raloxifene, clomifene, fulvestrant",0.661543506395395,0.161780778092374,FALSE +"H1650","Pearson.est","FGFR inhibitor",0.38321,0.91,0.587,378,0.975,"regorafenib, PD.173074, dovitinib",0.231361898752386,0.0109953843014632,FALSE +"H1650","Pearson.est","FLT3 inhibitor",0.57249,1.36,0.113,436,0.838,"gilteritinib, KW.2449, tozasertib, ponatinib, TG.02, pacritinib, lestaurtinib, TG.101348, ENMD.2076, dovitinib, sunitinib",0.94692155651658,0.0767559813697235,FALSE +"H1650","Pearson.est","glucocorticoid receptor agonist",0.55703,1.34,0.137,407,0.758,"hydrocortisone, prednisolone, ciclesonide, fluocinolone.acetonide, triamcinolone.acetonide, rimexolone, halobetasol.propionate, difluprednate, methylprednisolone, desonide, fluticasone.propionate, flumethasone.pivalate, halcinonide, triamcinolone, prednisolone.acetate",0.863279432843593,0.120330794367946,FALSE +"H1650","Pearson.est","glutamate receptor antagonist",0.29918,0.714,0.843,160,1,"diazooxonorleucine, SIB.1757",0.0741724253752577,0,FALSE +"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.3524,0.848,0.669,615,1,"tideglusib, TWS.119, CHIR.99021, kenpaullone, AZD2858",0.174573882232177,0,FALSE +"H1650","Pearson.est","growth factor receptor inhibitor",0.65866,1.57,0.0297,327,0.304,"GSK1838705A, AZD3463, PHA.848125, danusertib, lestaurtinib, GSK1904529A",1.52724355068279,0.517126416391246,FALSE +"H1650","Pearson.est","HCV inhibitor",0.41615,0.992,0.493,600,0.927,"embelin, PSI.7976, mericitabine",0.30715308072277,0.0329202658555029,FALSE +"H1650","Pearson.est","HDAC inhibitor",0.22243,0.543,0.952,555,1,"PCI.24781, givinostat, trichostatin.a, panobinostat, AR.42, resminostat, belinostat, entinostat, dacinostat, R306465",0.0213630516155257,0,FALSE +"H1650","Pearson.est","histamine receptor antagonist",0.2411,0.575,0.951,923,1,"pheniramine, astemizole, tiotidine, ranitidine, ICI.162846, epinastine, BF2.649, zolantidine, levocetirizine, famotidine, tecastemizole, cimetidine, nizatidine, cyproheptadine",0.0218194830625861,0,FALSE +"H1650","Pearson.est","HMGCR inhibitor",-0.41401,-1.27,0.195,597,0.413,"lovastatin, simvastatin, atorvastatin, mevastatin, fluvastatin, pitavastatin",0.709965388637482,0.384049948343599,FALSE +"H1650","Pearson.est","HSP inhibitor",-0.35367,-1.07,0.323,1294,0.502,"VER.49009, tanespimycin, guanidine, alvespimycin, KW.2478",0.490797477668897,0.299296282854981,FALSE +"H1650","Pearson.est","JAK inhibitor",0.49631,1.18,0.27,431,0.713,"atiprimod, TG.101209, tozasertib, AZ960, TG.02, AT.9283, pacritinib, lestaurtinib, TG.101348, AZD1480, filgotinib",0.568636235841013,0.146910470148134,FALSE +"H1650","Pearson.est","KIT inhibitor",0.39485,0.928,0.566,149,0.958,"KI.8751, regorafenib, OSI.930",0.247183568811729,0.0186344909214556,FALSE +"H1650","Pearson.est","MDM inhibitor",0.82133,1.94,0,180,0.0323,"idasanutlin, nutlin.3, serdemetan, CGM097, AMG.232",Inf,1.4907974776689,TRUE +"H1650","Pearson.est","MEK inhibitor",0.86838,2.1,0,96,0.00468,"cobimetinib, AZD8330, AS.703026, PD.0325901, trametinib, TAK.733, MEK162, Ro.4987655, selumetinib, PD.318088, refametinib, PD.198306, PD.184352",Inf,2.32975414692588,TRUE +"H1650","Pearson.est","MET inhibitor",0.33916,0.808,0.71,678,1,"PHA.665752, LY2801653, AMG458",0.148741651280925,0,FALSE +"H1650","Pearson.est","microtubule inhibitor",0.31595,0.756,0.796,608,1,"vinflunine, podophyllotoxin, vinblastine, D.64131, triclabendazole, secnidazole",0.0990869322623309,0,FALSE +"H1650","Pearson.est","mTOR inhibitor",0.36306,0.853,0.689,463,1,"XL388, WAY.600, ku.0063794, LY303511, WYE.354, torin.1, PF.04691502, PP242, OSI.027, palomid.529, GSK2126458, voxtalisib, AZD8055",0.161780778092374,0,FALSE +"H1650","Pearson.est","NFkB pathway inhibitor",0.27807,0.663,0.89,621,1,"bortezomib, curcumin, betulinic.acid, parthenolide...., EVP4593, parthenolide",0.0506099933550872,0,FALSE +"H1650","Pearson.est","opioid receptor agonist",0.49789,1.18,0.251,562,0.713,"trimebutine, salvinorin.a, cebranopadol",0.600326278518962,0.146910470148134,FALSE +"H1650","Pearson.est","p38 MAPK inhibitor",0.44356,1.06,0.401,696,0.854,"skepinone.l, SB.242235, VX.702, TAK.715, CMPD.1",0.396855627379818,0.068542129310995,FALSE +"H1650","Pearson.est","PARP inhibitor",0.54492,1.29,0.159,333,0.707,"talazoparib, niraparib, AG.14361",0.798602875679548,0.150580586203101,FALSE +"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.23349,0.561,0.949,448,1,"KI.8751, regorafenib, ponatinib, dovitinib, sunitinib, crenolanib",0.0227337875727074,0,FALSE +"H1650","Pearson.est","phosphatase inhibitor",0.24877,0.592,0.941,225,1,"GSK2830371, sodium.stibogluconate",0.0264103765727431,0,FALSE +"H1650","Pearson.est","phosphodiesterase inhibitor",-0.33171,-0.984,0.428,477,0.553,"avanafil, GSK256066, EMD.53998, anagrelide, zardaverine, cilostamide, YM.976, trequinsin, papaverine, enoximone",0.368556230986828,0.257274868695302,FALSE +"H1650","Pearson.est","PI3K inhibitor",0.3958,0.931,0.564,503,0.975,"YM.201636, LY303511, buparlisib, PIK.75, ZSTK.474, GDC.0941, AZD6482, PF.04691502, GSK2126458, voxtalisib, TG.100713",0.248720896016658,0.0109953843014632,FALSE +"H1650","Pearson.est","PLK inhibitor",0.62742,1.48,0.0734,296,0.487,"rigosertib, NMS.1286937, volasertib, GSK461364",1.13430394008393,0.312471038785366,FALSE +"H1650","Pearson.est","potassium channel blocker",-0.38488,-1.18,0.252,555,0.485,"meglitinide, oleoylethanolamide, ML133, ibutilide, mepivacaine, dofetilide",0.598599459218456,0.314258261397736,FALSE +"H1650","Pearson.est","PPAR receptor agonist",-0.38793,-1.15,0.265,559,0.477,"ciprofibrate, oleoylethanolamide, fenofibrate, clofibrate, S26948, pterostilbene, GW.501516",0.576754126063192,0.321481620959886,FALSE +"H1650","Pearson.est","progesterone receptor agonist",0.32588,0.774,0.755,426,1,"melengestrol.acetate, nomegestrol.acetate, tanaproget",0.122053048370812,0,FALSE +"H1650","Pearson.est","proteasome inhibitor",0.20868,0.498,0.979,563,1,"bortezomib, ixazomib, MG.132",0.00921730819686218,0,FALSE +"H1650","Pearson.est","protein synthesis inhibitor",0.41826,0.988,0.493,120,0.912,"brefeldin.a, cycloheximide, homoharringtonine",0.30715308072277,0.0400051616715838,FALSE +"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.29662,0.699,0.842,57,1,"NVP.TAE226",0.0746879085003505,0,FALSE +"H1650","Pearson.est","RAF inhibitor",0.74518,1.76,0.00585,144,0.106,"AZ.628, dabrafenib, CEP.32496, GDC.0879, LGX818, SB.590885, vemurafenib, regorafenib",2.23284413391782,0.97469413473523,TRUE +"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.48011,1.14,0.284,670,0.801,"regorafenib, sunitinib, sorafenib, vandetanib",0.546681659952962,0.0963674839157623,FALSE +"H1650","Pearson.est","retinoid receptor agonist",0.4206,1,0.482,281,0.933,"tamibarotene, CD.437, adarotene",0.31695296176115,0.0301183562535,FALSE +"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.54497,1.3,0.165,331,0.723,"LY2334737, triapine, clofarabine, fludarabine.phosphate, cladribine",0.782516055786094,0.140861702705469,FALSE +"H1650","Pearson.est","serotonin receptor agonist",0.28963,0.693,0.849,855,1,"NAN.190, ipsapirone, aripiprazole, SR.57227A, zolmitriptan",0.0710923097560473,0,FALSE +"H1650","Pearson.est","serotonin receptor antagonist",0.55315,1.34,0.126,274,0.758,"pirenperone, sertindole, paliperidone, SB.216641, SB.200646, lerisetron",0.899629454882437,0.120330794367946,FALSE +"H1650","Pearson.est","sodium channel blocker",0.32985,0.785,0.75,419,1,"ajmaline, mexiletine, benzethonium, quinidine, butamben",0.1249387366083,0,FALSE +"H1650","Pearson.est","src inhibitor",0.27796,0.668,0.891,51,1,"PP.2",0.0501222959631252,0,FALSE +"H1650","Pearson.est","sterol demethylase inhibitor",-0.38003,-1.13,0.256,548,0.455,"terconazole, posaconazole, lanoconazole, ketoconazole, sulconazole, chlormidazole",0.59176003468815,0.341988603342888,FALSE +"H1650","Pearson.est","TGF beta receptor inhibitor",-0.42718,-1.28,0.155,616,0.464,"SB.525334, D.4476, adaprev, SB.431542, repsox, LY2109761",0.809668301829709,0.333482019445119,FALSE +"H1650","Pearson.est","thymidylate synthase inhibitor",0.75588,1.79,0.0034,295,0.109,"carmofur, raltitrexed, trifluridine, ftorafur",2.46852108295775,0.962573502059376,TRUE +"H1650","Pearson.est","topoisomerase inhibitor",0.38246,0.899,0.601,681,0.976,"amsacrine, topotecan, fleroxacin, idarubicin, voreloxin, teniposide, TAS.103, SN.38, exatecan.mesylate, rubitecan, daunorubicin, valrubicin, nemorubicin, doxorubicin, genz.644282, licochalcone.a",0.22112552799726,0.0105501823333082,FALSE +"H1650","Pearson.est","tubulin polymerization inhibitor",0.52319,1.25,0.206,479,0.706,"verubulin, indibulin, albendazole, fosbretabulin, oxibendazole, parbendazole, podophyllotoxin, nocodazole, vindesine, vinorelbine, vinblastine, epothilone.b, BNC105, combretastatin.A.4, taltobulin, plinabulin, vincristine, dolastatin.10",0.686132779630847,0.151195298948196,FALSE +"H1650","Pearson.est","tyrosine kinase inhibitor",0.31444,0.758,0.769,708,1,"NVP.TAE226, regorafenib, bafetinib, aminopurvalanol.a, tivantinib, UNC2250, sunitinib, tyrphostin.A9, PP.121, hypericin, sorafenib, vandetanib, dasatinib",0.114073660198569,0,FALSE +"H1650","Pearson.est","VEGFR inhibitor",0.19227,0.457,0.983,796,1,"KI.8751, regorafenib, OSI.930, PD.173074, ENMD.2076, TG.100572, dovitinib, sunitinib, RAF265, sorafenib, golvatinib, vandetanib, axitinib, semaxanib, MK.2461, SAR131675, orantinib, vatalanib, pazopanib",0.00744648216786438,0,FALSE +"H1650","Pearson.est","vitamin D receptor agonist",-0.51224,-1.63,0.0192,1326,0.725,"calcitriol, maxacalcitol",1.71669877129645,0.139661993429006,FALSE +"HCC95","Pearson.est","EGFR inhibitor",-0.82172,-2.01,0,1330,0.0316,"CNX.2006, CUDC.101, TAK.285, PD.168393, GW.583340, BMS.599626, WZ8040, brigatinib, AST.1306, WZ.3146, icotinib, WZ.4002, BIBX.1382, ARRY.334543, CP.724714, AEE788, pelitinib, BMS.690514, tucatinib, rociletinib, lapatinib, neratinib, AZD8931, dacomitinib, osimertinib, erlotinib, XL.647, gefitinib, afatinib, canertinib, poziotinib",Inf,1.5003129173816,TRUE +"HCC95","Pearson.est","Abl kinase inhibitor",-0.37517,-0.915,0.568,1227,0.85,"metatinib, bosutinib, ZM.306416",0.245651664288981,0.0705810742857073,FALSE +"HCC95","Pearson.est","acetylcholine receptor agonist",0.52402,1.42,0.135,407,0.303,"tremorine, nefiracetam, oxiracetam, nicotine, pilocarpine",0.869666231504994,0.518557371497695,FALSE +"HCC95","Pearson.est","acetylcholine receptor antagonist",0.46524,1.29,0.161,19,0.395,"iododexetimide",0.79317412396815,0.40340290437354,FALSE +"HCC95","Pearson.est","adenosine receptor antagonist",-0.54128,-1.33,0.147,1443,0.455,"CGS.15943",0.832682665251824,0.341988603342888,FALSE +"HCC95","Pearson.est","adrenergic receptor agonist",0.37474,1.03,0.411,386,0.558,"ritodrine, isoxsuprine, isoetharine, oxymetazoline, norepinephrine, epinephrine, xylazine",0.386158178123931,0.253365801062421,FALSE +"HCC95","Pearson.est","adrenergic receptor antagonist",-0.22971,-0.571,0.932,1081,1,"dihydroergocristine, vincamine, carvedilol, RS.17053, imiloxan",0.0305840876460186,0,FALSE +"HCC95","Pearson.est","AKT inhibitor",-0.60551,-1.45,0.0902,1305,0.361,"CCT128930, GDC.0068, triciribine, uprosertib",1.04479346245806,0.442492798094342,FALSE +"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.73298,-1.78,0.0147,1246,0.134,"SB.505124, CEP.37440, alectinib, NVP.TAE684, AZD3463, brigatinib",1.83268266525182,0.872895201635192,TRUE +"HCC95","Pearson.est","androgen receptor antagonist",0.63795,1.67,0.0458,222,0.201,"bicalutamide, enzalutamide",1.33913452199613,0.696803942579511,TRUE +"HCC95","Pearson.est","antioxidant",0.74347,2.06,0,200,0.0553,"benfotiamine, chlorogenic.acid, trolox, mesna",Inf,1.2572748686953,TRUE +"HCC95","Pearson.est","AP inhibitor",0.41269,1.15,0.277,22,0.442,"idronoxil",0.557520230935551,0.354577730650908,FALSE +"HCC95","Pearson.est","ATPase inhibitor",-0.5272,-1.27,0.186,1057,0.497,"digitoxigenin, omeprazole, evodiamine, digoxin, oligomycin.a, NMS.873, k.strophanthidin, rabeprazole",0.730487055782084,0.303643611266668,FALSE +"HCC95","Pearson.est","Aurora kinase inhibitor",-0.65344,-1.59,0.0318,1085,0.271,"barasertib, GSK1070916, CCT137690, PF.03814735, MK.5108, alisertib, aurora.a.inhibitor.i, ENMD.2076, CCT129202, hesperadin, MLN.8054, MK.8745, CYC116, ZM.447439, TAK.901, danusertib, barasertib.HQPA, PHA.680632",1.49757288001557,0.567030709125594,FALSE +"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.45658,-1.12,0.318,1024,0.646,"tedizolid, valnemulin, azithromycin, radezolid",0.497572880015567,0.189767482004916,FALSE +"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.56518,1.58,0.0733,116,0.225,"nadifloxacin, novobiocin, sparfloxacin",1.13489602535887,0.647817481888638,FALSE +"HCC95","Pearson.est","BCL inhibitor",0.53749,1.47,0.107,400,0.279,"oridonin, venetoclax, ABT.737, navitoclax, gossypol",0.97061622231479,0.554395796726402,FALSE +"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.24612,-0.59,0.909,1227,1,"metatinib, bosutinib",0.0414361167780325,0,FALSE +"HCC95","Pearson.est","benzodiazepine receptor agonist",-0.20328,-0.498,0.981,1064,1,"ZK.93423, ivermectin, bentazepam",0.0083309926200515,0,FALSE +"HCC95","Pearson.est","bromodomain inhibitor",-0.5225,-1.3,0.193,1029,0.463,"JQ1...., I.BET151, OTX015, I.BET.762",0.714442690992226,0.334419008982047,FALSE +"HCC95","Pearson.est","calcium channel blocker",-0.42758,-1.06,0.373,873,0.691,"tetrandrine, fendiline, carboxyamidotriazole, efonidipine.monoethanolate, penfluridol",0.428291168191312,0.160521952625802,FALSE +"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.25951,-0.63,0.906,1044,1,"MK.0812, SB.225002, ZK811752",0.0428718023231869,0,FALSE +"HCC95","Pearson.est","CDK inhibitor",-0.60637,-1.47,0.0849,1012,0.386,"CR8..R., ribociclib, palbociclib, PHA.848125, dinaciclib, alvocidib, TG.02, aminopurvalanol.a, R547, arcyriaflavin.a, JNJ.7706621, indisulam, BMS.265246, PHA.793887, BMS.387032, AT.7519",1.07109230975605,0.413412695328245,FALSE +"HCC95","Pearson.est","CHK inhibitor",-0.39923,-0.975,0.489,765,0.784,"AZD7762, PF.477736, CHIR.124, LY2603618, SB.218078",0.31069114087638,0.105683937315562,FALSE +"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.1866,-0.455,0.991,787,1,"indoprofen, sulfasalazine, curcumin, piroxicam, aspirin, phenazone, FR.122047, ramifenazone, FK.3311, tryptanthrin, amfenac",0.00392634551472468,0,FALSE +"HCC95","Pearson.est","cytochrome P450 inhibitor",0.62507,1.79,0.0261,181,0.167,"metyrapone, morin, clotrimazole",1.58335949266172,0.777283528852417,TRUE +"HCC95","Pearson.est","DNA alkylating agent",-0.28241,-0.687,0.819,1096,1,"cyclophosphamide, mitomycin.c, estramustine, dacarbazine",0.0867160982395816,0,FALSE +"HCC95","Pearson.est","DNA inhibitor",0.37521,1.02,0.411,248,0.524,"nimorazole, metronidazole, carboplatin, bendamustine, pibenzimol, nithiamide, carmustine",0.386158178123931,0.280668713016273,FALSE +"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.66148,-1.59,0.042,1146,0.271,"fdcyd, SGI.1027, azacitidine, decitabine",1.3767507096021,0.567030709125594,FALSE +"HCC95","Pearson.est","DNA polymerase inhibitor",-0.2787,-0.678,0.859,1380,1,"cephalomannine",0.0660068361687577,0,FALSE +"HCC95","Pearson.est","DNA synthesis inhibitor",-0.41843,-1.03,0.427,1211,0.727,"mitomycin.c, anisomycin, cyclocytidine, enocitabine",0.369572124974976,0.138465589140962,FALSE +"HCC95","Pearson.est","dopamine receptor antagonist",0.22873,0.63,0.87,144,1,"amisulpride, clebopride, ziprasidone",0.0604807473813815,0,FALSE +"HCC95","Pearson.est","estrogen receptor agonist",-0.3061,-0.738,0.765,1362,1,"levonorgestrel",0.116338564846382,0,FALSE +"HCC95","Pearson.est","estrogen receptor antagonist",0.42984,1.18,0.257,92,0.428,"danazol, toremifene",0.590066876668705,0.368556230986828,FALSE +"HCC95","Pearson.est","FGFR inhibitor",0.21958,0.616,0.898,202,0.977,"erdafitinib, orantinib",0.0467236633326956,0.0101054362812269,FALSE +"HCC95","Pearson.est","FLT3 inhibitor",0.20475,0.556,0.962,397,0.987,"GTP.14564, ponatinib, gilteritinib, midostaurin, KW.2449, dovitinib, tyrphostin.AG.1296, tandutinib",0.0168249279621871,0.00568284733036327,FALSE +"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.40631,-0.988,0.459,1001,0.784,"betamethasone, methylprednisolone, halcinonide, difluprednate, clobetasol.propionate, flumethasone.pivalate, deflazacort, beclomethasone.dipropionate, triamcinolone.acetonide, halobetasol.propionate, ciclesonide, flumethasone, fluorometholone",0.338187314462739,0.105683937315562,FALSE +"HCC95","Pearson.est","glutamate receptor antagonist",-0.17529,-0.424,0.997,1344,0.995,"LY456236",0.00130484168834428,0.00217691925427455,FALSE +"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.73408,2.03,0,130,0.0522,"CHIR.98014, CHIR.99021, GSK.3.inhibitor.IX, tideglusib, LY2090314",Inf,1.28232949699774,TRUE +"HCC95","Pearson.est","growth factor receptor inhibitor",-0.55436,-1.33,0.161,935,0.455,"lestaurtinib, PHA.848125, GSK1838705A, danusertib, AZD3463",0.79317412396815,0.341988603342888,FALSE +"HCC95","Pearson.est","HCV inhibitor",0.24965,0.668,0.869,1088,0.993,"Ro.9187, embelin, mericitabine, daclatasvir, PSI.7976, narlaprevir",0.0609802235513335,0.00305075150461883,FALSE +"HCC95","Pearson.est","HDAC inhibitor",-0.38257,-0.928,0.537,847,0.851,"resminostat, R306465, RGFP966, chidamide, AR.42, belinostat, ACY.1215, M.344, trichostatin.a, NSC.3852, scriptaid, vorinostat, PCI.24781, JNJ.26481585, givinostat, dacinostat, SB.939",0.270025714300444,0.0700704399154121,FALSE +"HCC95","Pearson.est","histamine receptor antagonist",0.12867,0.35,1,1264,1,"epinastine, lafutidine, chloropyramine, nizatidine, famotidine, ICI.162846, cimetidine, pheniramine, tecastemizole, astemizole, ranitidine, tiotidine, cyproheptadine, zolantidine, BF2.649, terfenadine, levocetirizine, ebastine",0,0,FALSE +"HCC95","Pearson.est","HMGCR inhibitor",0.9154,2.5,0,128,0,"lovastatin, pitavastatin, fluvastatin, mevastatin, atorvastatin, simvastatin",Inf,Inf,TRUE +"HCC95","Pearson.est","HSP inhibitor",-0.58608,-1.4,0.116,931,0.375,"ganetespib, XL888, VER.49009, alvespimycin, NVP.AUY922, BIIB021, KW.2478, tanespimycin, PU.H71",0.935542010773082,0.425968732272281,FALSE +"HCC95","Pearson.est","JAK inhibitor",-0.53095,-1.31,0.193,1008,0.468,"baricitinib, AT.9283, LY2784544, WHI.P154, TG.02, AZD1480, ruxolitinib, AZ960, pacritinib, filgotinib, PRT062070",0.714442690992226,0.329754146925876,FALSE +"HCC95","Pearson.est","KIT inhibitor",-0.19135,-0.465,0.993,1033,1,"lenvatinib, vatalanib, cediranib, OSI.930",0.00305075150461883,0,FALSE +"HCC95","Pearson.est","MDM inhibitor",0.85188,2.36,0,71,0.00404,"AMG.232, idasanutlin, CGM097, nutlin.3",Inf,2.3936186348894,TRUE +"HCC95","Pearson.est","MEK inhibitor",0.43088,1.18,0.267,392,0.428,"refametinib, BIX.02188, cobimetinib, U.0126, TAK.733, MEK1.2.inhibitor, PD.184352, MEK162",0.573488738635425,0.368556230986828,FALSE +"HCC95","Pearson.est","MET inhibitor",0.60658,1.68,0.0458,213,0.226,"PHA.665752, NVP.BVU972, AMG458",1.33913452199613,0.645891560852599,TRUE +"HCC95","Pearson.est","microtubule inhibitor",-0.59596,-1.46,0.0804,1139,0.373,"podophyllotoxin, colchicine, vinflunine, cabazitaxel, D.64131",1.09474395125155,0.428291168191312,FALSE +"HCC95","Pearson.est","mTOR inhibitor",-0.45945,-1.12,0.329,1056,0.646,"PP242, torin.1, MLN0128, WYE.125132, torin.2, deforolimus, AZD8055, PI.103, GDC.0980, WYE.354, GSK2126458, PF.05212384",0.482804102050026,0.189767482004916,FALSE +"HCC95","Pearson.est","NFkB pathway inhibitor",-0.20611,-0.5,0.983,832,1,"curcumin, parthenolide...., IKK.2.inhibitor.V, parthenolide, Ro.106.9920, EVP4593",0.00744648216786438,0,FALSE +"HCC95","Pearson.est","opioid receptor agonist",0.49728,1.33,0.166,103,0.373,"BW.180C, ADL5859",0.779891911959945,0.428291168191312,FALSE +"HCC95","Pearson.est","p38 MAPK inhibitor",-0.58875,-1.41,0.103,1240,0.381,"CMPD.1, SB.239063, talmapimod",0.987162775294828,0.419075024324381,FALSE +"HCC95","Pearson.est","PARP inhibitor",-0.36089,-0.872,0.62,907,0.908,"AZD2461, olaparib, PJ.34, niraparib, talazoparib",0.207608310501746,0.0419141514789149,FALSE +"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.2569,0.705,0.784,464,0.976,"KI.8751, orantinib, ponatinib, linifanib, dovitinib, CP.673451, telatinib, tandutinib, pazopanib, sunitinib, regorafenib, trapidil",0.105683937315562,0.0105501823333082,FALSE +"HCC95","Pearson.est","phosphatase inhibitor",0.45718,1.25,0.212,232,0.418,"bis.maltolato.oxovanadium.IV., GSK2830371, BVT.948, menadione, CID.5458317",0.673664139071249,0.378823718224965,FALSE +"HCC95","Pearson.est","phosphodiesterase inhibitor",0.37454,1.02,0.41,121,0.524,"anagrelide, GSK256066, enoximone",0.387216143280265,0.280668713016273,FALSE +"HCC95","Pearson.est","PI3K inhibitor",-0.49432,-1.19,0.253,1196,0.604,"TG.100713, PI.103, GDC.0980, PIK.75, GSK2126458, CH5132799, PF.05212384, alpelisib, taselisib",0.596879478824182,0.218963061378868,FALSE +"HCC95","Pearson.est","PLK inhibitor",-0.814,-1.97,0,1348,0.0307,"GW.843682X, HMN.214, BI.2536, volasertib, NMS.1286937",Inf,1.51286162452281,TRUE +"HCC95","Pearson.est","potassium channel blocker",0.3966,1.13,0.308,212,0.444,"meglitinide, ML133",0.511449283499556,0.35261702988538,FALSE +"HCC95","Pearson.est","PPAR receptor agonist",0.57999,1.62,0.0655,132,0.219,"fenofibrate, S26948, clofibrate",1.18375870000822,0.659555885159882,FALSE +"HCC95","Pearson.est","progesterone receptor agonist",0.54867,1.48,0.1,198,0.297,"norethindrone, nomegestrol.acetate, danazol, norethindrone.acetate, norgestrel",1,0.527243550682788,FALSE +"HCC95","Pearson.est","proteasome inhibitor",-0.44815,-1.07,0.368,1178,0.696,"carfilzomib",0.434152181326482,0.157390760389438,FALSE +"HCC95","Pearson.est","protein synthesis inhibitor",-0.51442,-1.22,0.22,1181,0.57,"thiostrepton, cycloheximide, harringtonine, anguidine, puromycin, homoharringtonine, tedizolid.phosphate, bruceantin",0.657577319177794,0.244125144327509,FALSE +"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.74314,-1.78,0.00855,1372,0.134,"BMS.599626, NVP.TAE226, CP.724714, AV.412",2.06803388527183,0.872895201635192,TRUE +"HCC95","Pearson.est","RAF inhibitor",0.44794,1.24,0.235,35,0.403,"dabrafenib, vemurafenib",0.628932137728264,0.39469495385889,FALSE +"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.32328,-0.791,0.708,1037,1,"cabozantinib, vandetanib",0.149966742310231,0,FALSE +"HCC95","Pearson.est","retinoid receptor agonist",-0.35302,-0.86,0.627,971,0.905,"adarotene, bexarotene, adapalene, CD.437",0.202732459169284,0.0433514207947967,FALSE +"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.30177,0.832,0.625,241,0.794,"pentostatin, hydroxyurea, fludarabine",0.204119982655925,0.100179497572904,FALSE +"HCC95","Pearson.est","serotonin receptor agonist",-0.65005,-1.57,0.0427,1238,0.27,"zolmitriptan, pardoprunox, aripiprazole",1.36957212497498,0.568636235841013,FALSE +"HCC95","Pearson.est","serotonin receptor antagonist",-0.31608,-0.766,0.763,1436,1,"aripiprazole",0.11747546204512,0,FALSE +"HCC95","Pearson.est","sodium channel blocker",-0.24539,-0.589,0.927,960,1,"benzethonium, triamterene, lappaconite, A.803467, brivaracetam",0.0329202658555029,0,FALSE +"HCC95","Pearson.est","src inhibitor",-0.71705,-1.73,0.0171,1369,0.157,"bosutinib, saracatinib, ZM.306416",1.76700388960785,0.804100347590766,TRUE +"HCC95","Pearson.est","sterol demethylase inhibitor",-0.23717,-0.582,0.918,342,1,"posaconazole, terconazole, ketoconazole, chlormidazole, sulconazole, lanoconazole",0.0371573187987575,0,FALSE +"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.60175,-1.47,0.0727,1083,0.386,"adaprev, SB.525334, D.4476, repsox",1.13846558914096,0.413412695328245,FALSE +"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.24124,-0.593,0.905,1268,1,"carmofur",0.0433514207947967,0,FALSE +"HCC95","Pearson.est","topoisomerase inhibitor",-0.43995,-1.07,0.395,798,0.696,"licochalcone.a, epirubicin, voreloxin, valrubicin, teniposide, idarubicin, daunorubicin, beta.lapachone, etoposide, amsacrine, TAS.103, irinotecan, mitoxantrone, genz.644282, amonafide, camptothecin, SN.38, exatecan.mesylate, dexrazoxane",0.40340290437354,0.157390760389438,FALSE +"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.6977,-1.68,0.0192,1139,0.198,"podophyllotoxin, combretastatin.A.4, flubendazole, indibulin, CYT.997, plinabulin, albendazole, fenbendazole, vincristine, mebendazole, dolastatin.10, fosbretabulin, taltobulin, nocodazole, ABT.751, vinorelbine, epothilone.b, parbendazole, docetaxel, paclitaxel",1.71669877129645,0.703334809738469,TRUE +"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.46455,-1.12,0.336,1372,0.646,"BMS.599626, NVP.TAE226, CP.724714, AV.412, tivantinib",0.473660722610156,0.189767482004916,FALSE +"HCC95","Pearson.est","VEGFR inhibitor",-0.47148,-1.15,0.289,933,0.662,"SAR131675, RAF265, TG.100572, golvatinib, foretinib, semaxanib, lenvatinib, cabozantinib, SU014813, vatalanib, cediranib, ENMD.2076, PD.173074, lucitanib, vandetanib, OSI.930, ZM.306416, AEE788, BMS.690514, XL.647",0.539102157243452,0.1791420105603,FALSE +"HCC95","Pearson.est","vitamin D receptor agonist",-0.58103,-1.44,0.102,846,0.353,"ercalcitriol, calcitriol, doxercalciferol, paricalcitol, tacalcitol, maxacalcitol",0.991399828238082,0.452225294612177,FALSE +"H1975","Pearson.est","EGFR inhibitor",0.75378,1.74,0.0062,170,0.215,"gefitinib, poziotinib, AZD8931, afatinib, AST.1306, neratinib, dacomitinib, erlotinib, pelitinib, XL.647, BIBU.1361, CUDC.101, lapatinib, osimertinib, BMS.690514, canertinib, ARRY.334543, vandetanib, WZ.4002, tucatinib, CNX.2006, PD.153035, BIBX.1382, AEE788, BMS.599626, icotinib",2.20760831050175,0.667561540084395,TRUE +"H1975","Pearson.est","Abl kinase inhibitor",0.44677,1.06,0.405,666,0.769,"ZM.306416, dasatinib, bosutinib, bafetinib, nilotinib, GZD824, imatinib, tozasertib",0.392544976785331,0.114073660198569,FALSE +"H1975","Pearson.est","acetylcholine receptor agonist",0.31852,0.738,0.792,634,0.941,"pilocarpine, tremorine, xanomeline, oxiracetam",0.101274818410506,0.0264103765727431,FALSE +"H1975","Pearson.est","acetylcholine receptor antagonist",-0.3726,-1.03,0.407,1262,0.869,"iododexetimide, methscopolamine",0.39040559077478,0.0609802235513335,FALSE +"H1975","Pearson.est","adenosine receptor antagonist",0.53704,1.27,0.188,399,0.549,"CGS.15943, PSB.1115, istradefylline, MRS.1220, SCH.58261, sulmazole",0.72584215073632,0.260427655549908,FALSE +"H1975","Pearson.est","adrenergic receptor agonist",-0.42733,-1.23,0.165,1186,0.749,"clenbuterol, midodrine, epinephrine, A61603, norepinephrine, lidamidine, xylazine",0.782516055786094,0.125518182300534,FALSE +"H1975","Pearson.est","adrenergic receptor antagonist",0.2973,0.689,0.845,567,0.94,"atenolol......, dihydroergocristine, dronedarone, oxprenolol, imiloxan, idazoxan, practolol, naftidrofuryl, prazosin",0.0731432910503077,0.0268721464003014,FALSE +"H1975","Pearson.est","AKT inhibitor",0.42379,0.995,0.475,438,0.76,"uprosertib, triciribine, palomid.529, GDC.0068, GSK2110183",0.323306390375133,0.119186407719209,FALSE +"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.41655,0.969,0.521,727,0.749,"AZD3463, alectinib, CEP.37440, SB.505124, NVP.TAE684, brigatinib, crizotinib, DMH1, lorlatinib",0.283162276700476,0.125518182300534,FALSE +"H1975","Pearson.est","androgen receptor antagonist",-0.32119,-0.878,0.551,1255,0.943,"enzalutamide, flutamide",0.258848401148215,0.0254883072626717,FALSE +"H1975","Pearson.est","antioxidant",-0.35198,-1.01,0.369,1332,0.853,"taurine, rutin",0.43297363384094,0.069050968832477,FALSE +"H1975","Pearson.est","AP inhibitor",-0.71291,-2.1,0,1426,0.081,"birinapant, LCL.161, GDC.0152",Inf,1.09151498112135,TRUE +"H1975","Pearson.est","ATPase inhibitor",-0.39797,-1.14,0.263,1224,0.724,"oligomycin.a, blebbistatin...., ouabain, digitoxigenin, digitoxin, omeprazole",0.580044251510242,0.140261433802853,FALSE +"H1975","Pearson.est","Aurora kinase inhibitor",0.42594,1,0.448,690,0.795,"ENMD.2076, PHA.680632, danusertib, CCT137690, hesperadin, barasertib.HQPA, CCT129202, GSK1070916, alisertib, AT.9283, CYC116, SNS.314, barasertib, tozasertib, MK.8745, PF.03814735",0.348721986001856,0.0996328713435297,FALSE +"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.42094,0.966,0.521,600,0.716,"azithromycin, azalomycin.b, tilmicosin, tedizolid, valnemulin, radezolid",0.283162276700476,0.145086977692144,FALSE +"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.30415,-0.851,0.632,1428,0.864,"sparfloxacin",0.199282921717615,0.0634862575211067,FALSE +"H1975","Pearson.est","BCL inhibitor",0.63111,1.45,0.0754,166,0.557,"obatoclax, gossypol, TW.37",1.12262865413023,0.254144804826271,FALSE +"H1975","Pearson.est","Bcr.Abl kinase inhibitor",0.43761,1.03,0.423,666,0.783,"dasatinib, bosutinib, bafetinib, nilotinib, GZD824, imatinib, tozasertib",0.373659632624958,0.106238237942057,FALSE +"H1975","Pearson.est","benzodiazepine receptor agonist",0.27345,0.626,0.912,377,0.944,"eprinomectin, zaleplon, ZK.93423, piperazine",0.0400051616715838,0.025028005701931,FALSE +"H1975","Pearson.est","bromodomain inhibitor",0.71298,1.67,0.0114,303,0.265,"JQ1...., I.BET151, bromosporine, OTX015, I.BET.762",1.94309514866353,0.576754126063192,FALSE +"H1975","Pearson.est","calcium channel blocker",0.47116,1.09,0.353,256,0.783,"tetrandrine, cinnarazine, mibefradil",0.452225294612177,0.106238237942057,FALSE +"H1975","Pearson.est","CC chemokine receptor antagonist",0.46866,1.09,0.358,648,0.783,"ZK811752, SB.225002, PF.04136309, navarixin",0.446116973356126,0.106238237942057,FALSE +"H1975","Pearson.est","CDK inhibitor",0.56804,1.3,0.155,556,0.509,"TG.02, P276.00, R547, JNJ.7706621, indisulam, ribociclib, aminopurvalanol.a, PHA.848125, AZD5438, palbociclib, alvocidib, indirubin, BMS.387032, arcyriaflavin.a, AT.7519, NU6027, dinaciclib, abemaciclib",0.809668301829709,0.293282217663241,FALSE +"H1975","Pearson.est","CHK inhibitor",0.30654,0.707,0.846,781,0.939,"AZD7762, SB.218078, LY2603618, CHIR.124, PF.477736",0.0726296369609765,0.0273344077338891,FALSE +"H1975","Pearson.est","cyclooxygenase inhibitor",-0.20462,-0.592,0.908,1236,1,"amfenac, acetylsalicylsalicylic.acid, naproxen, AM.404, suxibuzone, metoxibutropate",0.0419141514789149,0,FALSE +"H1975","Pearson.est","cytochrome P450 inhibitor",-0.28623,-0.809,0.674,1244,0.903,"eplerenone, clotrimazole",0.17134010346468,0.0443122496864942,FALSE +"H1975","Pearson.est","DNA alkylating agent",-0.19577,-0.535,0.979,1259,1,"carboplatin, dianhydrogalactitol, cisplatin",0.00921730819686218,0,FALSE +"H1975","Pearson.est","DNA inhibitor",0.37094,0.865,0.642,684,0.815,"mechlorethamine, oxaliplatin, bendamustine, carmustine, nimorazole, sangivamycin, valrubicin, melphalan, nithiamide, busulfan",0.192464971931147,0.0888423912600234,FALSE +"H1975","Pearson.est","DNA methyltransferase inhibitor",0.59498,1.38,0.0907,213,0.531,"fdcyd, azacitidine, disulfiram",1.0423927129399,0.274905478918531,FALSE +"H1975","Pearson.est","DNA polymerase inhibitor",0.44102,1.04,0.426,333,0.786,"idoxuridine, adefovir.dipivoxil, trifluridine, cidofovir",0.370590400897281,0.104577453960592,FALSE +"H1975","Pearson.est","DNA synthesis inhibitor",0.32948,0.764,0.781,366,0.949,"anisomycin, enocitabine, cyclocytidine, floxuridine, CB.10.277",0.1073489661227,0.0227337875727074,FALSE +"H1975","Pearson.est","dopamine receptor antagonist",0.42308,0.997,0.468,125,0.778,"mesoridazine, sertindole, domperidone",0.329754146925876,0.109020403010311,FALSE +"H1975","Pearson.est","estrogen receptor agonist",-0.31695,-0.896,0.538,1386,0.953,"estradiol, estradiol.cypionate",0.269217724333611,0.0209070993616736,FALSE +"H1975","Pearson.est","estrogen receptor antagonist",0.45424,1.07,0.385,289,0.774,"clomifene, raloxifene",0.414539270491499,0.111259039317107,FALSE +"H1975","Pearson.est","FGFR inhibitor",0.32505,0.755,0.801,335,0.939,"regorafenib, PD.173074, dovitinib",0.0963674839157623,0.0273344077338891,FALSE +"H1975","Pearson.est","FLT3 inhibitor",0.4293,0.993,0.483,666,0.742,"pacritinib, TG.02, ENMD.2076, dovitinib, TG.101348, gilteritinib, sorafenib, GTP.14564, quizartinib, lestaurtinib, sunitinib, tozasertib",0.316052869248488,0.129596094720973,FALSE +"H1975","Pearson.est","glucocorticoid receptor agonist",0.70775,1.63,0.0201,234,0.279,"hydrocortisone, ciclesonide, triamcinolone.acetonide, difluprednate, desonide, halobetasol.propionate, rimexolone, methylprednisolone, halcinonide, fluocinolone.acetonide, flumethasone.pivalate, prednisolone, clobetasol.propionate, deflazacort, prednisolone.acetate, fludroxycortide, triamcinolone",1.69680394257951,0.554395796726402,FALSE +"H1975","Pearson.est","glutamate receptor antagonist",0.25863,0.598,0.9,176,0.929,"CPP, CGP.37849",0.0457574905606751,0.0319842860063582,FALSE +"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.30987,-0.867,0.575,1192,0.873,"tideglusib, CHIR.99021, CHIR.98014",0.24033215531037,0.0589857562944303,FALSE +"H1975","Pearson.est","growth factor receptor inhibitor",0.58508,1.36,0.127,577,0.494,"danusertib, AZD3463, GSK1838705A, PHA.848125, GSK1904529A, lestaurtinib",0.896196279044043,0.306273051076353,FALSE +"H1975","Pearson.est","HCV inhibitor",0.3914,0.92,0.575,231,0.743,"embelin",0.24033215531037,0.129011186239425,FALSE +"H1975","Pearson.est","HDAC inhibitor",0.41467,0.967,0.508,456,0.732,"PCI.24781, givinostat, AR.42, trichostatin.a, M.344, RGFP966, R306465, dacinostat, belinostat, scriptaid, NSC.3852, vorinostat, SB.939",0.294136287716081,0.135488918941608,FALSE +"H1975","Pearson.est","histamine receptor antagonist",-0.20597,-0.569,0.939,1228,1,"zolantidine, tiotidine, cimetidine, lafutidine, chloropyramine",0.0273344077338891,0,FALSE +"H1975","Pearson.est","HMGCR inhibitor",-0.8444,-2.41,0,1281,0.0088,"atorvastatin, fluvastatin, pitavastatin, mevastatin",Inf,2.05551732784983,TRUE +"H1975","Pearson.est","HSP inhibitor",-0.52195,-1.49,0.0739,1091,0.501,"BIIB021, PU.H71, NMS.E973, ganetespib, NVP.AUY922, guanidine, KW.2478, alvespimycin",1.13135556160517,0.300162274132754,FALSE +"H1975","Pearson.est","JAK inhibitor",0.4837,1.12,0.329,360,0.807,"pacritinib, atiprimod, TG.02, AZ960, TG.101209, AZD1480, LY2784544, TG.101348",0.482804102050026,0.0931264652779296,FALSE +"H1975","Pearson.est","KIT inhibitor",0.26704,0.621,0.921,653,0.93,"OSI.930, regorafenib, dasatinib, sorafenib, masitinib, imatinib, sunitinib",0.0357403698031511,0.0315170514460649,FALSE +"H1975","Pearson.est","MDM inhibitor",0.75333,1.75,0.00493,222,0.393,"nutlin.3, idasanutlin, RITA, CGM097, serdemetan",2.30715308072277,0.405607449624573,FALSE +"H1975","Pearson.est","MEK inhibitor",0.66147,1.56,0.0418,107,0.38,"cobimetinib, AS.703026, trametinib, PD.0325901, AZD8330, selumetinib, TAK.733, Ro.4987655, MEK162",1.37882371822496,0.42021640338319,FALSE +"H1975","Pearson.est","MET inhibitor",-0.62097,-1.72,0.0591,1261,0.27,"PF.04217903, LY2801653",1.22841251911874,0.568636235841013,FALSE +"H1975","Pearson.est","microtubule inhibitor",-0.38804,-1.08,0.335,558,0.808,"podophyllotoxin, D.64131, secnidazole, triclabendazole, vinflunine, colchicine, cabazitaxel, estramustine.phosphate, vinblastine, cytochalasin.b",0.474955192963155,0.0925886392254138,FALSE +"H1975","Pearson.est","mTOR inhibitor",0.60923,1.42,0.1,364,0.519,"GSK2126458, WAY.600, WYE.354, AZD8055, XL388, WYE.125132, PP242, OSI.027, voxtalisib, LY303511, AZD2014, torin.2, PF.04691502, torin.1, GDC.0980, palomid.529",1,0.284832642151542,FALSE +"H1975","Pearson.est","NFkB pathway inhibitor",0.27781,0.648,0.912,363,0.942,"EVP4593, curcumin, betulinic.acid",0.0400051616715838,0.0259490972071227,FALSE +"H1975","Pearson.est","opioid receptor agonist",-0.40275,-1.14,0.28,1312,0.724,"ADL5859, BW.180C, spiradoline",0.552841968657781,0.140261433802853,FALSE +"H1975","Pearson.est","p38 MAPK inhibitor",0.58902,1.38,0.1,565,0.531,"SB.242235, CMPD.1, skepinone.l, talmapimod, SB.239063, VX.702",1,0.274905478918531,FALSE +"H1975","Pearson.est","PARP inhibitor",-0.32294,-0.908,0.522,1372,0.982,"olaparib, E7449",0.282329496997738,0.00788851221305034,FALSE +"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.27858,-0.792,0.762,1257,0.897,"motesanib, trapidil, nintedanib, SU014813, CP.673451, linifanib",0.1180450286604,0.0472075569559079,FALSE +"H1975","Pearson.est","phosphatase inhibitor",0.28426,0.654,0.866,637,0.956,"alexidine, mycophenolic.acid, mycophenolate.mofetil, sodium.stibogluconate, CID.5458317, GSK2830371",0.0624821079826534,0.0195421077238999,FALSE +"H1975","Pearson.est","phosphodiesterase inhibitor",-0.32359,-0.953,0.469,1177,0.932,"zardaverine, anagrelide, YM.976, GSK256066, enoximone",0.328827157284917,0.0305840876460186,FALSE +"H1975","Pearson.est","PI3K inhibitor",0.56867,1.34,0.132,526,0.508,"GSK2126458, taselisib, YM.201636, GDC.0941, alpelisib, buparlisib, voxtalisib, PI3K.IN.2, LY303511, CH5132799, PIK.75, PF.04691502, GDC.0980, CUDC.907, PI.828, AZD6482, TG.100713, BGT226, pilaralisib, PI.103, PKI.179",0.87942606879415,0.294136287716081,FALSE +"H1975","Pearson.est","PLK inhibitor",0.48608,1.15,0.293,189,0.796,"NMS.1286937",0.533132379645891,0.0990869322623309,FALSE +"H1975","Pearson.est","potassium channel blocker",-0.32401,-0.871,0.58,1375,0.911,"dofetilide",0.236572006437063,0.0404816230270017,FALSE +"H1975","Pearson.est","PPAR receptor agonist",-0.4364,-1.25,0.183,1220,0.808,"fenofibrate, S26948, clofibrate",0.737548910269571,0.0925886392254138,FALSE +"H1975","Pearson.est","progesterone receptor agonist",-0.43153,-1.22,0.19,1358,0.689,"norethindrone, dienogest, norgestrel",0.721246399047171,0.161780778092374,FALSE +"H1975","Pearson.est","proteasome inhibitor",-0.50534,-1.46,0.0545,1389,0.462,"ONX.0914, delanzomib",1.26360349772336,0.335358024443874,FALSE +"H1975","Pearson.est","protein synthesis inhibitor",0.41908,0.987,0.482,515,0.734,"brefeldin.a, cycloheximide, azomycin..2.nitroimidazole., homoharringtonine, clindamycin.phosphate, anguidine, bruceantin, emetine, thiostrepton",0.31695296176115,0.134303940083929,FALSE +"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.6247,1.49,0.0605,243,0.507,"NVP.TAE226, AV.412, BMS.599626, tyrphostin.A9, CP.724714",1.21824462534753,0.294992040666664,FALSE +"H1975","Pearson.est","RAF inhibitor",0.56058,1.32,0.148,223,0.523,"AZ.628, SB.590885, CEP.32496, regorafenib, LGX818",0.829738284605043,0.281498311132726,FALSE +"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.5478,1.3,0.159,653,0.509,"vandetanib, regorafenib, sorafenib, apatinib, sunitinib",0.798602875679548,0.293282217663241,FALSE +"H1975","Pearson.est","retinoid receptor agonist",0.45567,1.08,0.351,313,0.779,"CD.437, tamibarotene, adarotene",0.454692883534176,0.108462542327436,FALSE +"H1975","Pearson.est","ribonucleotide reductase inhibitor",0.30906,0.716,0.829,660,0.948,"cytarabine, fludarabine.phosphate, LY2334737, triapine, clofarabine",0.0814454694497265,0.0231916626619338,FALSE +"H1975","Pearson.est","serotonin receptor agonist",-0.67324,-2.01,0.0193,1288,0.0998,"SR.57227A, pardoprunox, aripiprazole",1.71444269099223,1.00086945871263,TRUE +"H1975","Pearson.est","serotonin receptor antagonist",0.39151,0.928,0.57,267,0.747,"SB.228357, SB.200646, sertindole, SB.216641, pirenperone",0.244125144327509,0.126679398184601,FALSE +"H1975","Pearson.est","sodium channel blocker",-0.22201,-0.619,0.917,1248,1,"lappaconite, oxcarbazepine, brivaracetam, cibenzoline",0.0376306643299789,0,FALSE +"H1975","Pearson.est","src inhibitor",0.47974,1.14,0.313,356,0.787,"ZM.306416, saracatinib, dasatinib, bosutinib",0.504455662453552,0.104025267640935,FALSE +"H1975","Pearson.est","sterol demethylase inhibitor",0.43812,1.02,0.438,445,0.778,"lanoconazole, posaconazole, sulconazole",0.3585258894959,0.109020403010311,FALSE +"H1975","Pearson.est","TGF beta receptor inhibitor",0.49183,1.15,0.316,461,0.796,"D.4476, SB.525334, SB.431542, repsox",0.500312917381596,0.0990869322623309,FALSE +"H1975","Pearson.est","thymidylate synthase inhibitor",0.595,1.36,0.121,326,0.494,"carmofur, raltitrexed, trifluridine",0.91721462968355,0.306273051076353,FALSE +"H1975","Pearson.est","topoisomerase inhibitor",-0.17217,-0.481,0.985,245,0.989,"amsacrine, idarubicin, SN.38, exatecan.mesylate, voreloxin, valrubicin, licochalcone.a, TAS.103, camptothecin, dexrazoxane, teniposide, doxorubicin, nemorubicin, beta.lapachone, topotecan, fleroxacin, mitoxantrone, genz.644282, rubitecan, daunorubicin, amonafide, irinotecan, etoposide, epirubicin, etoposide.phosphate",0.00656376950238827,0.0048037084028206,FALSE +"H1975","Pearson.est","tubulin polymerization inhibitor",-0.20114,-0.559,0.958,1327,1,"docetaxel, vinblastine, paclitaxel, epothilone.d, BNC105",0.0186344909214556,0,FALSE +"H1975","Pearson.est","tyrosine kinase inhibitor",0.47713,1.1,0.342,441,0.824,"NVP.TAE226, vandetanib, AV.412, hypericin, BMS.599626, tyrphostin.A9, regorafenib, CP.724714, dasatinib, aminopurvalanol.a, tivantinib, sorafenib, bafetinib",0.465973893943865,0.0840727883028842,FALSE +"H1975","Pearson.est","VEGFR inhibitor",0.40466,0.957,0.541,335,0.714,"XL.647, BMS.690514, ZM.306416, OSI.930, vandetanib, ENMD.2076, AEE788, regorafenib, golvatinib, PD.173074, dovitinib",0.266802734893431,0.146301788223826,FALSE +"H1975","Pearson.est","vitamin D receptor agonist",0.6109,1.43,0.084,459,0.549,"tacalcitol, alfacalcidol, ercalcitriol, calcitriol, maxacalcitol",1.07572071393812,0.260427655549908,FALSE +"H1648","Pearson.est","EGFR inhibitor",-0.8675,-2.36,0.00325,1404,0.00209,"icotinib, BIBU.1361, PD.153035, AST.1306, TAK.285, AEE788, rociletinib, vandetanib, WZ8040, CP.724714, BMS.599626, BIBX.1382, pelitinib, GW.583340, ARRY.334543, PD.168393, erlotinib, gefitinib, osimertinib, afatinib, BMS.690514, lapatinib, dacomitinib, XL.647, canertinib, tucatinib, neratinib, poziotinib, AZD8931",2.48811663902113,2.67985371388895,TRUE +"H1648","Pearson.est","Abl kinase inhibitor",0.46859,1.11,0.335,264,0.59,"GZD824, tozasertib, ponatinib, nilotinib, bafetinib, KW.2449, flumatinib",0.474955192963155,0.229147988357856,FALSE +"H1648","Pearson.est","acetylcholine receptor agonist",0.52918,1.26,0.182,36,0.488,"oxiracetam",0.739928612014925,0.311580177997289,FALSE +"H1648","Pearson.est","acetylcholine receptor antagonist",0.50363,1.2,0.267,520,0.528,"iododexetimide, diphemanil, darifenacin",0.573488738635425,0.277366077466188,FALSE +"H1648","Pearson.est","adenosine receptor antagonist",-0.48527,-1.27,0.196,1291,0.559,"theophylline, MRS.1220, CGS.15943",0.707743928643524,0.252588192113577,FALSE +"H1648","Pearson.est","adrenergic receptor agonist",0.26433,0.634,0.903,794,0.985,"buphenine, isoetharine, oxymetazoline, norepinephrine, metaraminol, ritodrine, clenbuterol, lidamidine, isoxsuprine, midodrine",0.0443122496864942,0.00656376950238827,FALSE +"H1648","Pearson.est","adrenergic receptor antagonist",0.37103,0.879,0.615,452,0.785,"oxprenolol, metoprolol, carvedilol, naftidrofuryl, levobunolol, atipamezole, idazoxan",0.211124884224583,0.105130343254747,FALSE +"H1648","Pearson.est","AKT inhibitor",-0.62829,-1.65,0.0645,1247,0.323,"A.674563, GSK2110183, CCT128930, triciribine, uprosertib, GDC.0068",1.19044028536473,0.490797477668897,FALSE +"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27322,-0.707,0.798,1360,0.955,"GW.788388, brigatinib",0.0979971086492706,0.0199966284162537,FALSE +"H1648","Pearson.est","androgen receptor antagonist",0.51595,1.23,0.217,268,0.488,"nilutamide, bicalutamide",0.66354026615147,0.311580177997289,FALSE +"H1648","Pearson.est","antioxidant",0.63141,1.51,0.0641,258,0.451,"trolox, benfotiamine, chlorogenic.acid",1.19314197048118,0.345823458122039,FALSE +"H1648","Pearson.est","AP inhibitor",0.45152,1.07,0.374,239,0.593,"idronoxil, embelin",0.42712839779952,0.226945306635737,FALSE +"H1648","Pearson.est","ATPase inhibitor",0.30413,0.731,0.807,615,0.933,"digoxin, blebbistatin...., digitoxin, ouabain, thonzonium, evodiamine, digitoxigenin",0.0931264652779296,0.0301183562535,FALSE +"H1648","Pearson.est","Aurora kinase inhibitor",0.42414,1.02,0.446,412,0.629,"barasertib, tozasertib, AT.9283, AMG900, SNS.314, KW.2449, PF.03814735, hesperadin, barasertib.HQPA, ENMD.2076, alisertib",0.350665141287858,0.201349354554731,FALSE +"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.36159,-0.954,0.46,1248,0.974,"josamycin, tedizolid, azithromycin",0.337242168318426,0.0114410431213845,FALSE +"H1648","Pearson.est","bacterial DNA gyrase inhibitor",0.21439,0.521,0.98,633,0.987,"novobiocin, sparfloxacin, norfloxacin, sarafloxacin",0.00877392430750515,0.00568284733036327,FALSE +"H1648","Pearson.est","BCL inhibitor",0.48386,1.17,0.263,553,0.513,"venetoclax, TW.37, oridonin, gossypol, ABT.737",0.580044251510242,0.289882634888184,FALSE +"H1648","Pearson.est","Bcr.Abl kinase inhibitor",0.55817,1.34,0.137,264,0.608,"GZD824, tozasertib, ponatinib, nilotinib, bafetinib, flumatinib",0.863279432843593,0.216096420727265,FALSE +"H1648","Pearson.est","benzodiazepine receptor agonist",0.31877,0.765,0.761,656,0.926,"temazepam, indiplon, ZK.93423, eprinomectin, zaleplon, piperazine, gamma.aminobutyric.acid",0.118615343229427,0.0333890133180656,FALSE +"H1648","Pearson.est","bromodomain inhibitor",-0.27947,-0.74,0.757,403,0.948,"bromosporine, PFI.1, I.BET.762, I.BET151, JQ1...., OTX015",0.120904120499927,0.0231916626619338,FALSE +"H1648","Pearson.est","calcium channel blocker",-0.28169,-0.762,0.782,1325,1,"fendiline, SKF.96365",0.106793246940152,0,FALSE +"H1648","Pearson.est","CC chemokine receptor antagonist",0.68501,1.63,0.0204,357,0.485,"UNBS.5162, navarixin, PF.04136309, SB.225002, MK.0812",1.6903698325741,0.314258261397736,FALSE +"H1648","Pearson.est","CDK inhibitor",-0.25131,-0.64,0.893,1371,1,"BMS.387032, indirubin, AT.7519",0.0491485411114536,0,FALSE +"H1648","Pearson.est","CHK inhibitor",-0.47606,-1.27,0.197,686,0.559,"SB.218078, PF.477736, SCH.900776, AZD7762, LY2606368, CHIR.124, LY2603618",0.705533773838407,0.252588192113577,FALSE +"H1648","Pearson.est","cyclooxygenase inhibitor",-0.20309,-0.541,0.961,1336,0.962,"tryptanthrin, ramifenazone, FK.3311, amfenac",0.0172766123314547,0.0168249279621871,FALSE +"H1648","Pearson.est","cytochrome P450 inhibitor",0.60897,1.45,0.0874,370,0.495,"metyrapone, morin, cobicistat, itraconazole",1.0584885673656,0.305394801066431,FALSE +"H1648","Pearson.est","DNA alkylating agent",0.37005,0.89,0.593,135,0.784,"melphalan, carboplatin, carmustine",0.226945306635737,0.105683937315562,FALSE +"H1648","Pearson.est","DNA inhibitor",0.41542,0.991,0.478,417,0.663,"melphalan, carboplatin, chlorambucil, carmustine, pibenzimol, bendamustine, valrubicin, teroxirone",0.320572103387881,0.178486471595227,FALSE +"H1648","Pearson.est","DNA methyltransferase inhibitor",-0.50353,-1.3,0.161,1380,0.655,"decitabine, azacitidine, SGI.1027",0.79317412396815,0.183758700008217,FALSE +"H1648","Pearson.est","DNA polymerase inhibitor",0.26677,0.645,0.884,495,0.993,"foscarnet, idoxuridine, trifluridine",0.0535477349869269,0.00305075150461883,FALSE +"H1648","Pearson.est","DNA synthesis inhibitor",0.49135,1.19,0.258,385,0.511,"nelarabine, azodicarbonamide, anisomycin, floxuridine, artesunate, artemisinin, CB.10.277",0.58838029403677,0.291579099865287,FALSE +"H1648","Pearson.est","dopamine receptor antagonist",0.27846,0.661,0.852,193,0.997,"amisulpride, raclopride, paliperidone",0.0695604052332999,0.00130484168834428,FALSE +"H1648","Pearson.est","estrogen receptor agonist",-0.27905,-0.746,0.786,1312,0.984,"erteberel, levonorgestrel",0.104577453960592,0.00700490156865849,FALSE +"H1648","Pearson.est","estrogen receptor antagonist",0.45424,1.1,0.367,324,0.574,"fulvestrant, danazol, toremifene",0.435333935747911,0.241088107602027,FALSE +"H1648","Pearson.est","FGFR inhibitor",0.64732,1.54,0.0435,236,0.441,"erdafitinib, dovitinib, regorafenib, nintedanib, MK.2461, orantinib",1.36151074304536,0.355561410532161,FALSE +"H1648","Pearson.est","FLT3 inhibitor",0.62797,1.48,0.0585,294,0.47,"dovitinib, TG.101348, tozasertib, midostaurin, ponatinib, quizartinib, sunitinib, KW.2449, lestaurtinib, gilteritinib",1.23284413391782,0.327902142064283,FALSE +"H1648","Pearson.est","glucocorticoid receptor agonist",-0.54631,-1.45,0.0886,1137,0.466,"difluprednate, dexamethasone.acetate, halobetasol.propionate, halcinonide, desonide, flumethasone.pivalate, methylprednisolone, beclomethasone.dipropionate, ciclesonide, fluorometholone, fludroxycortide, clobetasol.propionate, betamethasone, flumethasone, triamcinolone.acetonide",1.05256627811295,0.33161408331,FALSE +"H1648","Pearson.est","glutamate receptor antagonist",0.15631,0.369,1,741,0.999,"MTPG, ACDPP, IEM1754, diazooxonorleucine, felbamate, CPP, SIB.1757",0,0.000434511774017692,FALSE +"H1648","Pearson.est","glycogen synthase kinase inhibitor",0.31993,0.767,0.744,459,0.943,"tideglusib, CHIR.99021, CHIR.98014, GSK.3.inhibitor.IX",0.128427064454121,0.0254883072626717,FALSE +"H1648","Pearson.est","growth factor receptor inhibitor",0.37789,0.9,0.588,596,0.787,"lestaurtinib, danusertib, PHA.848125, GSK1838705A, AZD3463",0.230622673923862,0.104025267640935,FALSE +"H1648","Pearson.est","HCV inhibitor",0.49252,1.18,0.272,384,0.513,"narlaprevir, embelin, mericitabine",0.565431095965801,0.289882634888184,FALSE +"H1648","Pearson.est","HDAC inhibitor",0.30553,0.736,0.78,740,0.946,"entinostat, resminostat, dacinostat, trichostatin.a, RG2833, R306465, nexturastat.a, belinostat, M.344, vorinostat, ACY.1215, chidamide, scriptaid, NSC.3852, panobinostat",0.10790539730952,0.0241088635982073,FALSE +"H1648","Pearson.est","histamine receptor antagonist",0.24554,0.588,0.939,491,0.985,"pheniramine, famotidine, cimetidine, tiotidine, lafutidine, ICI.162846, epinastine, nizatidine",0.0273344077338891,0.00656376950238827,FALSE +"H1648","Pearson.est","HMGCR inhibitor",0.88532,2.13,0.00145,6,0.000981,"mevastatin, pitavastatin, fluvastatin, atorvastatin",2.83863199776503,3.00833099262005,TRUE +"H1648","Pearson.est","HSP inhibitor",-0.32629,-0.849,0.641,1307,0.948,"VER.49009, tanespimycin, alvespimycin, KW.2478",0.193141970481183,0.0231916626619338,FALSE +"H1648","Pearson.est","JAK inhibitor",0.45604,1.09,0.369,263,0.575,"TG.101348, tozasertib, AT.9283, TG.101209, AZ960, lestaurtinib",0.43297363384094,0.24033215531037,FALSE +"H1648","Pearson.est","KIT inhibitor",0.50095,1.19,0.279,529,0.511,"KI.8751, midostaurin, pazopanib, regorafenib, sunitinib, masitinib, motesanib, telatinib, sorafenib, lenvatinib",0.554395796726402,0.291579099865287,FALSE +"H1648","Pearson.est","MDM inhibitor",0.87828,2.14,0,80,0.00196,"idasanutlin, AMG.232, nutlin.3, CGM097, serdemetan",Inf,2.70774392864352,TRUE +"H1648","Pearson.est","MEK inhibitor",-0.33511,-0.894,0.579,1141,0.912,"PD.198306, PD.318088, PD.0325901, PD.184352, AZD8330, Ro.4987655, selumetinib, AS.703026, trametinib",0.237321436272564,0.0400051616715838,FALSE +"H1648","Pearson.est","MET inhibitor",-0.35399,-0.934,0.517,1422,0.947,"INC.280",0.286509456906058,0.0236500209967266,FALSE +"H1648","Pearson.est","microtubule inhibitor",0.54939,1.3,0.158,133,0.498,"vinblastine, secnidazole, vinflunine",0.801342913045577,0.302770657240282,FALSE +"H1648","Pearson.est","mTOR inhibitor",0.22145,0.537,0.964,669,0.998,"torin.1, ku.0063794, deforolimus, LY303511, WAY.600, SB.2343, LY3023414, sirolimus, NVP.BEZ235, PKI.179, XL388, temsirolimus, AZD8055, AZD2014",0.0159229660971692,0.000869458712628891,FALSE +"H1648","Pearson.est","NFkB pathway inhibitor",-0.2305,-0.618,0.895,331,0.98,"BAY.11.7082, bortezomib, betulinic.acid, BAY.11.7085, curcumin, parthenolide...., parthenolide, bindarit, EVP4593, tyloxapol, Ro.106.9920, IKK.2.inhibitor.V",0.048176964684088,0.00877392430750515,FALSE +"H1648","Pearson.est","opioid receptor agonist",0.59792,1.44,0.0795,518,0.473,"cebranopadol, trimebutine, BW.180C, spiradoline, salvinorin.a",1.09963287134353,0.325138859262188,FALSE +"H1648","Pearson.est","p38 MAPK inhibitor",-0.42596,-1.09,0.361,1323,0.879,"SB.239063, talmapimod",0.442492798094342,0.0560111249262281,FALSE +"H1648","Pearson.est","PARP inhibitor",0.55286,1.33,0.154,433,0.591,"talazoparib, AG.14361, niraparib, PJ.34",0.812479279163537,0.228412519118745,FALSE +"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.54535,1.31,0.153,529,0.504,"KI.8751, dovitinib, axitinib, ponatinib, pazopanib, regorafenib, sunitinib, nintedanib, orantinib, masitinib, CP.673451, SU014813, crenolanib, trapidil, motesanib, telatinib, sorafenib, lenvatinib",0.815308569182401,0.297569463554475,FALSE +"H1648","Pearson.est","phosphatase inhibitor",0.6766,1.6,0.0322,61,0.455,"bis.maltolato.oxovanadium.IV., GSK2830371, BVT.948, sodium.stibogluconate",1.49214412830417,0.341988603342888,FALSE +"H1648","Pearson.est","phosphodiesterase inhibitor",0.53453,1.26,0.183,33,0.488,"anagrelide, GSK256066",0.737548910269571,0.311580177997289,FALSE +"H1648","Pearson.est","PI3K inhibitor",-0.34815,-0.928,0.521,1265,0.896,"TG.100713, PF.05212384, GDC.0980, GSK2126458, CH5132799, alpelisib, taselisib",0.283162276700476,0.0476919903378748,FALSE +"H1648","Pearson.est","PLK inhibitor",0.57843,1.37,0.121,379,0.622,"rigosertib, volasertib, GSK461364",0.91721462968355,0.206209615309181,FALSE +"H1648","Pearson.est","potassium channel blocker",0.52543,1.25,0.184,558,0.488,"meglitinide, dofetilide, mepivacaine, oleoylethanolamide",0.735182176990464,0.311580177997289,FALSE +"H1648","Pearson.est","PPAR receptor agonist",0.45597,1.1,0.359,698,0.574,"clofibrate, GW.501516, fenofibrate, oleoylethanolamide, S26948, ciprofibrate",0.444905551421681,0.241088107602027,FALSE +"H1648","Pearson.est","progesterone receptor agonist",0.55625,1.32,0.155,153,0.577,"norethindrone, danazol, tanaproget",0.809668301829709,0.238824186844269,FALSE +"H1648","Pearson.est","proteasome inhibitor",0.54645,1.31,0.153,536,0.504,"ixazomib, MG.132, delanzomib, oprozomib, bortezomib, ONX.0914",0.815308569182401,0.297569463554475,FALSE +"H1648","Pearson.est","protein synthesis inhibitor",0.43581,1.06,0.393,336,0.593,"brefeldin.a, mercaptopurine, cycloheximide, homoharringtonine, harringtonine, methacycline, anguidine",0.405607449624573,0.226945306635737,FALSE +"H1648","Pearson.est","protein tyrosine kinase inhibitor",-0.73932,-1.96,0.00687,1418,0.0805,"CP.724714, BMS.599626, AV.412",2.16304326294045,1.09420411963213,TRUE +"H1648","Pearson.est","RAF inhibitor",0.54133,1.31,0.156,640,0.504,"dabrafenib, vemurafenib, regorafenib, TAK.632, LGX818, GDC.0879, CEP.32496, sorafenib, RAF265, SB.590885, AZ.628",0.806875401645538,0.297569463554475,FALSE +"H1648","Pearson.est","RET tyrosine kinase inhibitor",0.38665,0.929,0.564,151,0.754,"regorafenib, sunitinib",0.248720896016658,0.122628654130226,FALSE +"H1648","Pearson.est","retinoid receptor agonist",0.25275,0.6,0.912,137,0.994,"fenretinide",0.0400051616715838,0.00261361560268669,FALSE +"H1648","Pearson.est","ribonucleotide reductase inhibitor",0.66371,1.57,0.0418,443,0.437,"cladribine, pentostatin, triapine, clofarabine, fludarabine, fludarabine.phosphate, hydroxyurea, LY2334737",1.37882371822496,0.359518563029578,FALSE +"H1648","Pearson.est","serotonin receptor agonist",0.56884,1.35,0.129,527,0.627,"NAN.190, aripiprazole, SR.57227A, ipsapirone",0.889410289700751,0.202732459169284,FALSE +"H1648","Pearson.est","serotonin receptor antagonist",0.51875,1.24,0.221,262,0.487,"lerisetron, SB.200646, aripiprazole, paliperidone, pirenperone",0.655607726314889,0.312471038785366,FALSE +"H1648","Pearson.est","sodium channel blocker",-0.20939,-0.546,0.969,1286,0.997,"A.803467, lappaconite, brivaracetam",0.0136762229492347,0.00130484168834428,FALSE +"H1648","Pearson.est","src inhibitor",-0.58654,-1.55,0.0629,1332,0.389,"dasatinib, bosutinib, ZM.306416, saracatinib",1.20134935455473,0.410050398674292,FALSE +"H1648","Pearson.est","sterol demethylase inhibitor",0.5386,1.28,0.181,347,0.49,"ketoconazole, posaconazole, chlormidazole, lanoconazole",0.742321425130815,0.309803919971486,FALSE +"H1648","Pearson.est","TGF beta receptor inhibitor",-0.38776,-1.06,0.377,1402,0.866,"repsox",0.423658649794207,0.0624821079826534,FALSE +"H1648","Pearson.est","thymidylate synthase inhibitor",0.42473,1.02,0.444,523,0.629,"ftorafur, trifluridine, doxifluridine, raltitrexed",0.35261702988538,0.201349354554731,FALSE +"H1648","Pearson.est","topoisomerase inhibitor",0.53522,1.28,0.167,415,0.49,"nemorubicin, etoposide.phosphate, topotecan, teniposide, daunorubicin, voreloxin, doxorubicin, amsacrine, epirubicin, rubitecan, idarubicin, TAS.103, valrubicin, amonafide, etoposide",0.777283528852417,0.309803919971486,FALSE +"H1648","Pearson.est","tubulin polymerization inhibitor",0.492,1.16,0.29,511,0.515,"verubulin, vinblastine, BNC105, taltobulin, combretastatin.A.4, vindesine, CYT.997, vincristine, plinabulin, KX2.391, fosbretabulin, vinorelbine, podophyllotoxin, dolastatin.10",0.537602002101044,0.288192770958809,FALSE +"H1648","Pearson.est","tyrosine kinase inhibitor",-0.36687,-0.965,0.48,1415,1,"vandetanib, CP.724714, BMS.599626, AV.412",0.318758762624413,0,FALSE +"H1648","Pearson.est","VEGFR inhibitor",-0.30751,-0.794,0.652,1411,1,"AEE788, vandetanib, ZM.306416, BMS.690514, XL.647",0.18575240426808,0,FALSE +"H1648","Pearson.est","vitamin D receptor agonist",-0.85631,-2.28,0,1299,0.00627,"ercalcitriol, paricalcitol, tacalcitol, calcitriol, maxacalcitol",Inf,2.20273245916928,TRUE +"H2126","Pearson.est","EGFR inhibitor",-0.83003,-2.18,0,1371,0.0166,"rociletinib, AST.1306, vandetanib, BIBU.1361, afatinib, WZ8040, PD.153035, TAK.285, erlotinib, AEE788, CUDC.101, dacomitinib, ARRY.334543, BMS.599626, BIBX.1382, gefitinib, canertinib, osimertinib, CP.724714, GW.583340, XL.647, poziotinib, PD.168393, BMS.690514, lapatinib, neratinib, AZD8931, tucatinib",Inf,1.77989191195995,TRUE +"H2126","Pearson.est","Abl kinase inhibitor",0.48701,1.19,0.256,94,0.593,"ponatinib, GZD824, tozasertib, KW.2449",0.59176003468815,0.226945306635737,FALSE +"H2126","Pearson.est","acetylcholine receptor agonist",0.31132,0.769,0.766,79,0.882,"oxiracetam",0.115771230367396,0.0545314148681803,FALSE +"H2126","Pearson.est","acetylcholine receptor antagonist",0.23508,0.583,0.946,216,0.986,"iododexetimide",0.0241088635982073,0.0061230850587888,FALSE +"H2126","Pearson.est","adenosine receptor antagonist",-0.74087,-1.96,0.0119,1390,0.0524,"SCH.58261, MRS.1220, CGS.15943",1.92445303860747,1.28066871301627,TRUE +"H2126","Pearson.est","adrenergic receptor agonist",0.28732,0.682,0.848,538,0.943,"midodrine, lidamidine, buphenine, clenbuterol, oxymetazoline, terbutaline, ritodrine",0.0716041477432862,0.0254883072626717,FALSE +"H2126","Pearson.est","adrenergic receptor antagonist",0.22516,0.549,0.946,499,0.991,"oxprenolol, idazoxan, carvedilol, metoprolol, levobunolol, naftidrofuryl, atipamezole",0.0241088635982073,0.00392634551472468,FALSE +"H2126","Pearson.est","AKT inhibitor",-0.72093,-1.91,0.00893,1295,0.0523,"triciribine, A.674563, CCT128930, uprosertib, GSK2110183, GDC.0068",2.04914854111145,1.28149831113273,TRUE +"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.41451,0.994,0.475,346,0.784,"lorlatinib, DMH1, AZD3463, alectinib",0.323306390375133,0.105683937315562,FALSE +"H2126","Pearson.est","androgen receptor antagonist",0.37416,0.909,0.565,505,0.86,"nilutamide, bicalutamide, cyproterone.acetate",0.247951552180562,0.0655015487564323,FALSE +"H2126","Pearson.est","antioxidant",0.50686,1.23,0.224,594,0.584,"mesna, trolox, benfotiamine, chlorogenic.acid",0.649751981665837,0.233587152887601,FALSE +"H2126","Pearson.est","AP inhibitor",0.33481,0.811,0.692,593,0.89,"idronoxil, embelin, GDC.0152, LCL.161, birinapant",0.159893905543242,0.0506099933550872,FALSE +"H2126","Pearson.est","ATPase inhibitor",0.41785,1.01,0.454,310,0.775,"ouabain, blebbistatin...., digitoxin, digoxin, thonzonium, digitoxigenin",0.342944147142896,0.11069829749369,FALSE +"H2126","Pearson.est","Aurora kinase inhibitor",0.48142,1.14,0.331,348,0.625,"barasertib, tozasertib, KW.2449, AT.9283, AMG900, SNS.314, PF.03814735, hesperadin, GSK1070916, barasertib.HQPA, alisertib, ENMD.2076",0.480172006224281,0.204119982655925,FALSE +"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.25396,0.611,0.911,153,0.981,"valnemulin",0.0404816230270017,0.0083309926200515,FALSE +"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.38054,0.931,0.525,136,0.862,"sparfloxacin, novobiocin",0.279840696594043,0.0644927341752872,FALSE +"H2126","Pearson.est","BCL inhibitor",0.39995,0.984,0.492,484,0.78,"venetoclax, obatoclax, TW.37, ABT.737, gossypol",0.30803489723264,0.10790539730952,FALSE +"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.54689,1.32,0.162,397,0.602,"ponatinib, GZD824, tozasertib, nilotinib, flumatinib, bafetinib",0.790484985457369,0.220403508742175,FALSE +"H2126","Pearson.est","benzodiazepine receptor agonist",0.21028,0.513,0.972,742,0.991,"temazepam, piperazine, indiplon, eprinomectin, zaleplon, gamma.aminobutyric.acid, ivermectin, ZK.93423, CGS.20625",0.0123337350737254,0.00392634551472468,FALSE +"H2126","Pearson.est","bromodomain inhibitor",-0.8054,-2.13,0,1285,0.0177,"I.BET151, OTX015, JQ1....",Inf,1.75202673363819,TRUE +"H2126","Pearson.est","calcium channel blocker",-0.36069,-0.952,0.451,1224,0.774,"SKF.96365, SR.33805, fendiline",0.345823458122039,0.111259039317107,FALSE +"H2126","Pearson.est","CC chemokine receptor antagonist",0.68157,1.68,0.0214,377,0.319,"UNBS.5162, SB.225002, navarixin, PF.04136309, MK.0812",1.66958622665081,0.496209316942819,FALSE +"H2126","Pearson.est","CDK inhibitor",-0.24804,-0.666,0.852,1427,0.938,"arcyriaflavin.a, indirubin",0.0695604052332999,0.0277971616209356,FALSE +"H2126","Pearson.est","CHK inhibitor",0.4989,1.24,0.215,466,0.617,"SCH.900776, LY2606368, PF.477736, SB.218078",0.667561540084395,0.209714835966758,FALSE +"H2126","Pearson.est","cyclooxygenase inhibitor",-0.17321,-0.466,0.997,1067,0.99,"metoxibutropate, meloxicam, sulfasalazine, AM.404, ramifenazone, aspirin, FK.3311, amfenac, tryptanthrin",0.00130484168834428,0.00436480540245009,FALSE +"H2126","Pearson.est","cytochrome P450 inhibitor",0.6974,1.72,0.0139,114,0.444,"metyrapone, itraconazole, morin",1.8569851997459,0.35261702988538,FALSE +"H2126","Pearson.est","DNA alkylating agent",0.50166,1.23,0.256,328,0.584,"melphalan, carmustine, carboplatin, temozolomide, estramustine, streptozotocin",0.59176003468815,0.233587152887601,FALSE +"H2126","Pearson.est","DNA inhibitor",0.3449,0.831,0.68,257,0.877,"melphalan, carmustine, chlorambucil, carboplatin",0.167491087293764,0.0570004066339595,FALSE +"H2126","Pearson.est","DNA methyltransferase inhibitor",-0.31449,-0.823,0.644,1256,0.822,"azacitidine, SGI.1027",0.191114132640188,0.0851281824599496,FALSE +"H2126","Pearson.est","DNA polymerase inhibitor",0.4831,1.17,0.277,497,0.586,"trifluridine, idoxuridine, adefovir.dipivoxil, foscarnet",0.557520230935551,0.232102383981909,FALSE +"H2126","Pearson.est","DNA synthesis inhibitor",0.41355,1.01,0.439,644,0.775,"nelarabine, anisomycin, floxuridine, cyclocytidine, artesunate, azodicarbonamide, artemisinin, capecitabine, CB.10.277",0.357535479757879,0.11069829749369,FALSE +"H2126","Pearson.est","dopamine receptor antagonist",0.31935,0.793,0.741,160,0.882,"raclopride, paliperidone, amisulpride, isofloxythepin",0.130181792020672,0.0545314148681803,FALSE +"H2126","Pearson.est","estrogen receptor agonist",0.2636,0.634,0.888,524,0.977,"estrone, PPT, estradiol",0.051587034221399,0.0101054362812269,FALSE +"H2126","Pearson.est","estrogen receptor antagonist",0.34524,0.842,0.642,476,0.879,"toremifene, fulvestrant, raloxifene, danazol",0.192464971931147,0.0560111249262281,FALSE +"H2126","Pearson.est","FGFR inhibitor",0.53259,1.28,0.196,247,0.59,"erdafitinib, dovitinib, MK.2461, regorafenib",0.707743928643524,0.229147988357856,FALSE +"H2126","Pearson.est","FLT3 inhibitor",0.57093,1.43,0.114,348,0.491,"ponatinib, gilteritinib, tozasertib, dovitinib, KW.2449, lestaurtinib, sunitinib, midostaurin, tyrphostin.AG.1296, quizartinib, ENMD.2076",0.943095148663527,0.308918507877032,FALSE +"H2126","Pearson.est","glucocorticoid receptor agonist",-0.30724,-0.808,0.679,1050,0.806,"deflazacort, rimexolone, halobetasol.propionate, betamethasone, beclomethasone.dipropionate, difluprednate, fludroxycortide, halcinonide, flumethasone, methylprednisolone, triamcinolone.acetonide, clobetasol.propionate",0.168130225719498,0.0936649581949093,FALSE +"H2126","Pearson.est","glutamate receptor antagonist",-0.36744,-0.977,0.476,1160,0.779,"CPP, ACDPP, latrepirdine, LY456236, tiletamine, CGP.37849",0.322393047279507,0.108462542327436,FALSE +"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.32802,-0.88,0.538,1431,0.807,"indirubin",0.269217724333611,0.0931264652779296,FALSE +"H2126","Pearson.est","growth factor receptor inhibitor",0.47401,1.13,0.324,261,0.623,"PHA.848125, GSK1838705A, lestaurtinib, AZD3463",0.489454989793388,0.20551195334083,FALSE +"H2126","Pearson.est","HCV inhibitor",0.48922,1.2,0.267,386,0.596,"narlaprevir, embelin, mericitabine",0.573488738635425,0.224753740259764,FALSE +"H2126","Pearson.est","HDAC inhibitor",-0.63626,-1.73,0.0338,1080,0.119,"vorinostat, R306465, panobinostat, scriptaid, AR.42, tacedinaline, romidepsin, PCI.24781, M.344, JNJ.26481585, givinostat, mocetinostat, SB.939, pyroxamide",1.47108329972235,0.924453038607469,TRUE +"H2126","Pearson.est","histamine receptor antagonist",0.29944,0.719,0.82,302,0.915,"cimetidine, pheniramine, astemizole, tiotidine, famotidine",0.0861861476162833,0.0385789059335517,FALSE +"H2126","Pearson.est","HMGCR inhibitor",0.91756,2.25,0,14,0,"fluvastatin, atorvastatin, mevastatin, pitavastatin",Inf,Inf,TRUE +"H2126","Pearson.est","HSP inhibitor",0.45381,1.11,0.361,326,0.642,"SNX.2112, NVP.AUY922, ganetespib, NMS.E973, BIIB021, SNX.5422, PU.H71",0.442492798094342,0.192464971931147,FALSE +"H2126","Pearson.est","JAK inhibitor",0.35905,0.864,0.633,503,0.902,"tozasertib, AT.9283, lestaurtinib, AZ960, PRT062070, TG.101209, TG.101348",0.198596289982645,0.0447934624580583,FALSE +"H2126","Pearson.est","KIT inhibitor",0.49951,1.21,0.256,634,0.602,"KI.8751, sunitinib, midostaurin, motesanib, regorafenib, cediranib, pazopanib, lenvatinib, telatinib, dasatinib, sorafenib, OSI.930, masitinib",0.59176003468815,0.220403508742175,FALSE +"H2126","Pearson.est","MDM inhibitor",-0.31739,-0.829,0.669,1421,0.856,"RITA",0.174573882232177,0.0675262353228468,FALSE +"H2126","Pearson.est","MEK inhibitor",0.32807,0.808,0.671,755,0.876,"PD.318088, U.0126, cobimetinib, AZD8330, PD.0325901, refametinib, TAK.733, Ro.4987655, AS.703026, arctigenin, MEK162, BIX.02188",0.173277479831008,0.0574958938319193,FALSE +"H2126","Pearson.est","MET inhibitor",-0.4006,-1.03,0.415,1387,0.727,"NVP.BVU972, INC.280",0.381951903287907,0.138465589140962,FALSE +"H2126","Pearson.est","microtubule inhibitor",0.67524,1.66,0.0368,173,0.208,"vinblastine, vinflunine, podophyllotoxin, cabazitaxel, secnidazole",1.43415218132648,0.681936665037238,TRUE +"H2126","Pearson.est","mTOR inhibitor",-0.33124,-0.886,0.537,1111,0.847,"XL388, torin.2, voxtalisib, palomid.529, PP242, WYE.125132, PF.05212384, GDC.0980, PI.103, GSK2126458",0.270025714300444,0.0721165896692931,FALSE +"H2126","Pearson.est","NFkB pathway inhibitor",-0.18063,-0.478,0.989,1203,1,"Ro.106.9920, EVP4593, tyloxapol",0.0048037084028206,0,FALSE +"H2126","Pearson.est","opioid receptor agonist",0.56838,1.37,0.131,460,0.52,"spiradoline, cebranopadol, trimebutine, BW.180C",0.882728704344236,0.283996656365201,FALSE +"H2126","Pearson.est","p38 MAPK inhibitor",-0.4372,-1.17,0.273,630,0.711,"skepinone.l, TAK.715, CMPD.1, SB.242235, VX.702, talmapimod, SB.239063",0.563837352959244,0.148130399270234,FALSE +"H2126","Pearson.est","PARP inhibitor",0.5628,1.41,0.102,275,0.5,"talazoparib, niraparib, olaparib",0.991399828238082,0.301029995663981,FALSE +"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.52686,1.27,0.207,548,0.581,"ponatinib, KI.8751, SU014813, axitinib, dovitinib, CP.673451, sunitinib, motesanib, regorafenib, pazopanib, lenvatinib, telatinib, nintedanib, crenolanib, dasatinib, sorafenib",0.684029654543082,0.235823867609669,FALSE +"H2126","Pearson.est","phosphatase inhibitor",0.56742,1.39,0.122,97,0.509,"bis.maltolato.oxovanadium.IV., BVT.948, sodium.stibogluconate, GSK2830371",0.913640169325252,0.293282217663241,FALSE +"H2126","Pearson.est","phosphodiesterase inhibitor",0.40722,1.01,0.462,250,0.775,"anagrelide, GSK256066, YM.976",0.335358024443874,0.11069829749369,FALSE +"H2126","Pearson.est","PI3K inhibitor",-0.44974,-1.2,0.243,1207,0.732,"CUDC.907, PI3K.IN.2, PI.828, PF.05212384, GDC.0980, PI.103, GSK2126458, CH5132799, alpelisib, taselisib",0.614393726401688,0.135488918941608,FALSE +"H2126","Pearson.est","PLK inhibitor",0.59805,1.46,0.0655,512,0.464,"rigosertib, GSK461364, volasertib, GW.843682X, HMN.214, BI.2536",1.18375870000822,0.333482019445119,FALSE +"H2126","Pearson.est","potassium channel blocker",0.30974,0.742,0.793,609,0.901,"dofetilide, mepivacaine, meglitinide",0.100726812682396,0.045275209020937,FALSE +"H2126","Pearson.est","PPAR receptor agonist",0.3599,0.856,0.646,140,0.895,"fenofibrate",0.189767482004916,0.048176964684088,FALSE +"H2126","Pearson.est","progesterone receptor agonist",0.3669,0.868,0.626,476,0.916,"norethindrone, tanaproget, danazol",0.20342566678957,0.0381045263321496,FALSE +"H2126","Pearson.est","proteasome inhibitor",0.68299,1.7,0.0141,294,0.357,"ixazomib, bortezomib, delanzomib, MG.132, carfilzomib",1.85078088734462,0.447331783887807,FALSE +"H2126","Pearson.est","protein synthesis inhibitor",0.49112,1.18,0.264,205,0.589,"brefeldin.a, mercaptopurine, cycloheximide, methacycline, homoharringtonine",0.578396073130169,0.229884705212898,FALSE +"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.75244,-1.93,0.00592,1249,0.0545,"tyrphostin.A9, mubritinib, AV.412, BMS.599626, CP.724714",2.22767829327708,1.26360349772336,TRUE +"H2126","Pearson.est","RAF inhibitor",0.66605,1.58,0.043,247,0.281,"dabrafenib, vemurafenib, RAF265, GDC.0879, LGX818, AZ.628, regorafenib",1.36653154442041,0.55129368009492,FALSE +"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.31953,0.775,0.739,247,0.89,"sunitinib, regorafenib",0.131355561605174,0.0506099933550872,FALSE +"H2126","Pearson.est","retinoid receptor agonist",0.3507,0.851,0.645,234,0.884,"adarotene, tamibarotene",0.190440285364732,0.0535477349869269,FALSE +"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.53448,1.29,0.185,428,0.597,"cladribine, clofarabine, triapine, fludarabine.phosphate, LY2334737, pentostatin, gemcitabine",0.732828271596986,0.224025668870631,FALSE +"H2126","Pearson.est","serotonin receptor agonist",0.67564,1.67,0.0259,267,0.272,"aripiprazole, NAN.190, ipsapirone, SR.57227A",1.58670023591875,0.565431095965801,FALSE +"H2126","Pearson.est","serotonin receptor antagonist",0.37798,0.916,0.567,119,0.867,"aripiprazole, lerisetron, paliperidone",0.246416941107093,0.0619809025237897,FALSE +"H2126","Pearson.est","sodium channel blocker",0.18867,0.455,0.994,516,0.991,"quinidine, mexiletine, benzocaine, mepivacaine",0.00261361560268669,0.00392634551472468,FALSE +"H2126","Pearson.est","src inhibitor",-0.39411,-1.05,0.361,1411,0.748,"ZM.306416, saracatinib",0.442492798094342,0.126098402135539,FALSE +"H2126","Pearson.est","sterol demethylase inhibitor",0.53761,1.29,0.18,571,0.597,"ketoconazole, posaconazole, lanoconazole, terconazole, chlormidazole",0.744727494896694,0.224025668870631,FALSE +"H2126","Pearson.est","TGF beta receptor inhibitor",-0.41401,-1.1,0.341,597,0.71,"D.4476, LY2109761, adaprev, SB.525334, SB.431542, repsox",0.467245621007502,0.148741651280925,FALSE +"H2126","Pearson.est","thymidylate synthase inhibitor",0.67145,1.63,0.0316,338,0.227,"raltitrexed, trifluridine, carmofur, ftorafur",1.5003129173816,0.643974142806877,TRUE +"H2126","Pearson.est","topoisomerase inhibitor",0.62204,1.49,0.089,286,0.434,"topotecan, etoposide.phosphate, teniposide, rubitecan, daunorubicin, nemorubicin, irinotecan, doxorubicin, voreloxin, SN.38, TAS.103, etoposide, idarubicin, amsacrine, dexrazoxane",1.05060999335509,0.362510270487489,FALSE +"H2126","Pearson.est","tubulin polymerization inhibitor",0.69618,1.66,0.0235,305,0.208,"verubulin, vinblastine, BNC105, taltobulin, vindesine, podophyllotoxin, CYT.997, docetaxel, vincristine, dolastatin.10, combretastatin.A.4, plinabulin, paclitaxel, fosbretabulin, ABT.751, vinorelbine, KX2.391, epothilone.b, indibulin",1.62893213772826,0.681936665037238,TRUE +"H2126","Pearson.est","tyrosine kinase inhibitor",-0.41526,-1.13,0.278,1320,0.716,"GTP.14564, mubritinib, vandetanib, AV.412, BMS.599626, CP.724714",0.555955204081924,0.145086977692144,FALSE +"H2126","Pearson.est","VEGFR inhibitor",-0.27477,-0.746,0.796,1382,0.867,"vandetanib, semaxanib, ZM.306416, AEE788, XL.647, BMS.690514",0.0990869322623309,0.0619809025237897,FALSE +"H2126","Pearson.est","vitamin D receptor agonist",-0.82106,-2.23,0,1345,0.0182,"ercalcitriol, paricalcitol, calcitriol, tacalcitol, maxacalcitol",Inf,1.73992861201493,TRUE +"H520","Pearson.est","EGFR inhibitor",0.72338,1.79,0.0174,130,0.191,"poziotinib, PD.153035, vandetanib, icotinib, erlotinib, pelitinib, XL.647, gefitinib, BIBU.1361, afatinib, dacomitinib, osimertinib, AZD8931, canertinib, lapatinib, AST.1306, neratinib, BMS.599626, PD.168393",1.7594507517174,0.718966632752272,TRUE +"H520","Pearson.est","Abl kinase inhibitor",0.6975,1.75,0.0153,321,0.197,"dasatinib, bosutinib, ZM.306416, GZD824, metatinib, ponatinib, nilotinib",1.8153085691824,0.705533773838407,TRUE +"H520","Pearson.est","acetylcholine receptor agonist",0.38711,0.955,0.522,201,0.98,"nicotine, pilocarpine",0.282329496997738,0.00877392430750515,FALSE +"H520","Pearson.est","acetylcholine receptor antagonist",-0.38687,-1.01,0.391,1404,0.993,"diphemanil",0.407823242604133,0.00305075150461883,FALSE +"H520","Pearson.est","adenosine receptor antagonist",0.38874,0.962,0.509,292,1,"PSB.1115, CGS.15943",0.293282217663241,0,FALSE +"H520","Pearson.est","adrenergic receptor agonist",0.46375,1.14,0.312,273,0.728,"ritodrine, isoxsuprine, oxymetazoline, buphenine, epinephrine",0.505845405981557,0.137868620686963,FALSE +"H520","Pearson.est","adrenergic receptor antagonist",-0.23295,-0.62,0.907,1066,1,"carvedilol, practolol, propranolol, metoprolol, dihydroergocristine, pindolol",0.0423927129399047,0,FALSE +"H520","Pearson.est","AKT inhibitor",-0.27207,-0.699,0.802,1177,1,"GSK2110183, ONC201, GDC.0068, A.674563",0.0958256317158365,0,FALSE +"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.2398,0.598,0.917,149,0.985,"lorlatinib, GW.788388",0.0376306643299789,0.00656376950238827,FALSE +"H520","Pearson.est","androgen receptor antagonist",0.29131,0.721,0.823,470,0.965,"RU.58841, nilutamide, bicalutamide",0.0846001647877302,0.0154726866562074,FALSE +"H520","Pearson.est","antioxidant",0.54097,1.32,0.172,309,0.637,"mesna, chlorogenic.acid",0.764471553092451,0.19586056766465,FALSE +"H520","Pearson.est","AP inhibitor",0.6253,1.59,0.0516,286,0.311,"birinapant, GDC.0152, LCL.161, embelin",1.28735029837279,0.507239610973163,FALSE +"H520","Pearson.est","ATPase inhibitor",-0.44657,-1.16,0.287,1201,0.751,"omeprazole, digoxin, evodiamine, rabeprazole, oligomycin.a",0.542118103266008,0.124360062995832,FALSE +"H520","Pearson.est","Aurora kinase inhibitor",-0.65043,-1.67,0.0408,1202,0.429,"PF.03814735, danusertib, AT.9283, SNS.314, PHA.680632, AMG900, aurora.a.inhibitor.i, MK.8745, TAK.901, CCT137690, barasertib.HQPA, barasertib, ZM.447439",1.38933983691012,0.367542707815276,FALSE +"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.38886,0.948,0.496,48,0.956,"tedizolid",0.304518323509803,0.0195421077238999,FALSE +"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.37796,0.939,0.506,14,0.937,"finafloxacin",0.295849483160201,0.0282604091122217,FALSE +"H520","Pearson.est","BCL inhibitor",-0.37735,-0.965,0.437,1126,0.991,"navitoclax, TW.37, HA14.1, ABT.737, oridonin",0.359518563029578,0.00392634551472468,FALSE +"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.70004,1.74,0.0216,321,0.169,"dasatinib, bosutinib, GZD824, metatinib, ponatinib, nilotinib",1.66554624884907,0.772113295386326,TRUE +"H520","Pearson.est","benzodiazepine receptor agonist",0.31482,0.782,0.715,329,0.983,"lorazepam, piperazine, eprinomectin, CGS.20625",0.145693958198919,0.00744648216786438,FALSE +"H520","Pearson.est","bromodomain inhibitor",-0.72072,-1.92,0.00771,1120,0.35,"bromosporine, I.BET.762, PFI.1, I.BET151, OTX015",2.11294562194904,0.455931955649724,FALSE +"H520","Pearson.est","calcium channel blocker",0.38857,0.964,0.495,278,1,"SKF.96365, efonidipine.monoethanolate, cinnarazine",0.305394801066431,0,FALSE +"H520","Pearson.est","CC chemokine receptor antagonist",0.49066,1.21,0.243,132,0.746,"navarixin, ZK811752",0.614393726401688,0.127261172527331,FALSE +"H520","Pearson.est","CDK inhibitor",0.21788,0.544,0.949,511,0.956,"AZD5438, alvocidib, palbociclib, kenpaullone, JNJ.7706621, ribociclib, aminopurvalanol.a, AT.7519, PHA.848125, P276.00",0.0227337875727074,0.0195421077238999,FALSE +"H520","Pearson.est","CHK inhibitor",-0.62331,-1.64,0.0644,1318,0.329,"SB.218078, PF.477736",1.19111413264019,0.482804102050026,FALSE +"H520","Pearson.est","cyclooxygenase inhibitor",-0.26361,-0.694,0.798,1342,1,"AM.404, sulfasalazine, naproxen",0.0979971086492706,0,FALSE +"H520","Pearson.est","cytochrome P450 inhibitor",0.62174,1.51,0.0701,268,0.423,"morin, metyrapone, itraconazole",1.15428198203334,0.373659632624958,FALSE +"H520","Pearson.est","DNA alkylating agent",-0.36093,-0.94,0.498,1273,0.903,"melphalan, satraplatin, dianhydrogalactitol, mitomycin.c",0.302770657240282,0.0443122496864942,FALSE +"H520","Pearson.est","DNA inhibitor",-0.36156,-0.984,0.462,1166,1,"primaquine, tirapazamine, melphalan, bendamustine, pibenzimol, chlorambucil, valrubicin, mechlorethamine",0.335358024443874,0,FALSE +"H520","Pearson.est","DNA methyltransferase inhibitor",-0.28711,-0.775,0.728,993,1,"fdcyd, disulfiram, SGI.1027",0.137868620686963,0,FALSE +"H520","Pearson.est","DNA polymerase inhibitor",0.25074,0.622,0.886,304,1,"foscarnet, adefovir.dipivoxil",0.0525662781129492,0,FALSE +"H520","Pearson.est","DNA synthesis inhibitor",-0.31062,-0.811,0.664,1237,1,"estramustine.phosphate, artemisinin, azodicarbonamide, mitomycin.c",0.177831920631982,0,FALSE +"H520","Pearson.est","dopamine receptor antagonist",0.45375,1.14,0.315,399,0.728,"clebopride, acetophenazine, oxiperomide, isofloxythepin, amisulpride, domperidone, piperacetazine, UH.232....",0.501689446210399,0.137868620686963,FALSE +"H520","Pearson.est","estrogen receptor agonist",0.23476,0.579,0.927,463,0.978,"erteberel, PPT, estrone, ethinyl.estradiol",0.0329202658555029,0.00966114521239857,FALSE +"H520","Pearson.est","estrogen receptor antagonist",0.36681,0.909,0.542,221,0.896,"raloxifene, clomifene",0.266000713461613,0.0476919903378748,FALSE +"H520","Pearson.est","FGFR inhibitor",-0.53967,-1.42,0.118,1255,0.521,"dovitinib, regorafenib, erdafitinib, lenvatinib, nintedanib",0.928117992693875,0.283162276700476,FALSE +"H520","Pearson.est","FLT3 inhibitor",-0.23279,-0.612,0.901,913,1,"lestaurtinib, pacritinib, tozasertib, tyrphostin.AG.1296, midostaurin, quizartinib, TG.02, ENMD.2076, sorafenib, dovitinib, TG.101348",0.045275209020937,0,FALSE +"H520","Pearson.est","glucocorticoid receptor agonist",0.52123,1.31,0.169,259,0.609,"hydrocortisone, fluocinolone.acetonide, ciclesonide, dexamethasone.acetate, flumethasone.pivalate, triamcinolone.acetonide, halobetasol.propionate, prednisolone.acetate, desonide",0.772113295386326,0.215382707367125,FALSE +"H520","Pearson.est","glutamate receptor antagonist",0.28854,0.722,0.799,312,0.991,"SIB.1757, diazooxonorleucine, MTPG, latrepirdine",0.0974532206860086,0.00392634551472468,FALSE +"H520","Pearson.est","glycogen synthase kinase inhibitor",0.36965,0.931,0.548,356,0.885,"LY2090314, tideglusib, kenpaullone, TWS.119",0.261219441515631,0.0530567293021746,FALSE +"H520","Pearson.est","growth factor receptor inhibitor",0.36099,0.869,0.607,53,0.913,"GSK1904529A",0.216811308924742,0.039529222465701,FALSE +"H520","Pearson.est","HCV inhibitor",0.37946,0.932,0.517,341,0.917,"PSI.7976, embelin, daclatasvir",0.286509456906058,0.0376306643299789,FALSE +"H520","Pearson.est","HDAC inhibitor",-0.57682,-1.56,0.0765,1052,0.347,"belinostat, nexturastat.a, entinostat, mocetinostat, trichostatin.a, dacinostat, PCI.24781, NSC.3852, RGFP966, ACY.1215, givinostat, SB.939, R306465, vorinostat, resminostat, chidamide, pyroxamide, scriptaid, M.344",1.11633856484638,0.459670525209126,FALSE +"H520","Pearson.est","histamine receptor antagonist",0.28328,0.726,0.776,426,1,"astemizole, ranitidine, terfenadine, zolantidine, levocetirizine, tecastemizole, cimetidine",0.110138278741812,0,FALSE +"H520","Pearson.est","HMGCR inhibitor",0.53804,1.34,0.159,466,0.708,"lovastatin, fluvastatin, pitavastatin, simvastatin",0.798602875679548,0.149966742310231,FALSE +"H520","Pearson.est","HSP inhibitor",-0.33422,-0.893,0.547,1439,0.965,"NMS.E973",0.262012673666569,0.0154726866562074,FALSE +"H520","Pearson.est","JAK inhibitor",-0.21345,-0.575,0.954,1167,0.968,"PRT062070, LY2784544, AT.9283, ruxolitinib, TG.101348",0.0204516252959049,0.0141246426916063,FALSE +"H520","Pearson.est","KIT inhibitor",0.29841,0.734,0.809,1,1,"dasatinib",0.0920514783877277,0,FALSE +"H520","Pearson.est","MDM inhibitor",0.47695,1.19,0.267,332,0.744,"idasanutlin, nutlin.3",0.573488738635425,0.128427064454121,FALSE +"H520","Pearson.est","MEK inhibitor",0.79814,2.02,0.00514,44,0.0597,"TAK.733, AZD8330, trametinib, PD.0325901, cobimetinib, Ro.4987655, refametinib, AS.703026, selumetinib, PD.318088, MEK162",2.28903688100472,1.22402566887063,TRUE +"H520","Pearson.est","MET inhibitor",-0.28754,-0.741,0.802,1082,1,"NVP.BVU972, INC.280, AMG458",0.0958256317158365,0,FALSE +"H520","Pearson.est","microtubule inhibitor",-0.39052,-1.02,0.404,1237,1,"estramustine.phosphate, vinflunine, colchicine",0.393618634889395,0,FALSE +"H520","Pearson.est","mTOR inhibitor",0.54424,1.35,0.162,494,0.757,"WAY.600, torin.1, WYE.354, OSI.027, LY303511, XL388, PP242, GSK2126458, AZD8055, SB.2343, PF.04691502, AZD2014, MLN0128, voxtalisib, LY3023414, ku.0063794, NVP.BEZ235, temsirolimus",0.790484985457369,0.120904120499927,FALSE +"H520","Pearson.est","NFkB pathway inhibitor",-0.23904,-0.612,0.923,1423,1,"BAY.11.7082",0.0347982989740879,0,FALSE +"H520","Pearson.est","opioid receptor agonist",0.52359,1.33,0.155,288,0.666,"ADL5859, trimebutine, BW.180C",0.809668301829709,0.176525770829699,FALSE +"H520","Pearson.est","p38 MAPK inhibitor",0.2219,0.557,0.939,425,0.97,"TAK.715, VX.702",0.0273344077338891,0.0132282657337552,FALSE +"H520","Pearson.est","PARP inhibitor",-0.65403,-1.69,0.02,1296,0.514,"PJ.34, olaparib, AZD2461, niraparib, talazoparib",1.69897000433602,0.289036881004724,FALSE +"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.31053,-0.814,0.688,1089,1,"motesanib, sorafenib, trapidil, masitinib, axitinib, dovitinib, regorafenib, linifanib, lenvatinib, pazopanib, nintedanib",0.162411561764489,0,FALSE +"H520","Pearson.est","phosphatase inhibitor",-0.31279,-0.8,0.668,1034,1,"menadione, AS.1949490, mycophenolate.mofetil, CID.5458317",0.175223537524454,0,FALSE +"H520","Pearson.est","phosphodiesterase inhibitor",-0.21295,-0.555,0.956,1373,0.955,"enoximone",0.0195421077238999,0.0199966284162537,FALSE +"H520","Pearson.est","PI3K inhibitor",0.3208,0.806,0.689,480,1,"TG.100713, LY303511, AZD6482, GSK2126458, SB.2343, buparlisib, PF.04691502, GDC.0941, voxtalisib, LY3023414, NVP.BEZ235, PIK.75",0.161780778092374,0,FALSE +"H520","Pearson.est","PLK inhibitor",-0.70099,-1.82,0.0217,1189,0.378,"HMN.214, BI.2536, NMS.1286937, volasertib",1.66354026615147,0.422508200162775,FALSE +"H520","Pearson.est","potassium channel blocker",-0.2982,-0.78,0.714,430,1,"oleoylethanolamide, mepivacaine, meglitinide, ML133, ibutilide, dofetilide",0.146301788223826,0,FALSE +"H520","Pearson.est","PPAR receptor agonist",-0.51085,-1.35,0.153,1170,0.536,"pterostilbene, clofibrate, ciprofibrate, GW.501516",0.815308569182401,0.27083521030723,FALSE +"H520","Pearson.est","progesterone receptor agonist",-0.23141,-0.609,0.894,333,0.993,"melengestrol.acetate, nomegestrol.acetate, levonorgestrel, norethindrone, dienogest, tanaproget, norethindrone.acetate, norgestrel, danazol",0.0486624812040823,0.00305075150461883,FALSE +"H520","Pearson.est","proteasome inhibitor",-0.26018,-0.677,0.848,1096,1,"oprozomib, delanzomib, MG.132",0.0716041477432862,0,FALSE +"H520","Pearson.est","protein synthesis inhibitor",-0.3581,-0.951,0.483,1246,0.971,"azomycin..2.nitroimidazole., harringtonine, bruceantin, homoharringtonine, clofoctol, anguidine",0.316052869248488,0.0127807700919951,FALSE +"H520","Pearson.est","protein tyrosine kinase inhibitor",0.27985,0.689,0.824,487,0.984,"BMS.599626, PP.121, AV.412, NVP.TAE226",0.0840727883028842,0.00700490156865849,FALSE +"H520","Pearson.est","RAF inhibitor",0.43296,1.09,0.365,305,0.795,"LGX818, AZ.628, CEP.32496, dabrafenib, vemurafenib, SB.590885",0.437707135543525,0.0996328713435297,FALSE +"H520","Pearson.est","RET tyrosine kinase inhibitor",0.52403,1.3,0.188,17,0.584,"vandetanib",0.72584215073632,0.233587152887601,FALSE +"H520","Pearson.est","retinoid receptor agonist",-0.49046,-1.25,0.231,1216,0.669,"adarotene, adapalene, bexarotene, fenretinide",0.636388020107856,0.174573882232177,FALSE +"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.60728,-1.6,0.061,1025,0.339,"gemcitabine, cladribine, fludarabine, clofarabine, hydroxyurea, cytarabine, pentostatin",1.21467016498923,0.469800301796918,FALSE +"H520","Pearson.est","serotonin receptor agonist",-0.52589,-1.39,0.145,1361,0.517,"zolmitriptan, aripiprazole",0.838631997765025,0.286509456906058,FALSE +"H520","Pearson.est","serotonin receptor antagonist",-0.35474,-0.949,0.506,1447,0.927,"aripiprazole",0.295849483160201,0.0329202658555029,FALSE +"H520","Pearson.est","sodium channel blocker",-0.22785,-0.604,0.908,1203,0.97,"brivaracetam, triamterene, oxcarbazepine, cibenzoline",0.0419141514789149,0.0132282657337552,FALSE +"H520","Pearson.est","src inhibitor",0.6866,1.69,0.0371,83,0.202,"dasatinib, PP.2, saracatinib, bosutinib, ZM.306416",1.43062609038495,0.694648630553376,TRUE +"H520","Pearson.est","sterol demethylase inhibitor",0.36398,0.906,0.552,169,0.871,"sulconazole, terconazole",0.258060922270801,0.0599818449923368,FALSE +"H520","Pearson.est","TGF beta receptor inhibitor",0.45947,1.14,0.297,92,0.728,"repsox",0.527243550682788,0.137868620686963,FALSE +"H520","Pearson.est","thymidylate synthase inhibitor",0.73357,1.8,0.00984,313,0.269,"carmofur, capecitabine, ftorafur, raltitrexed",2.00700490156866,0.570247719997592,FALSE +"H520","Pearson.est","topoisomerase inhibitor",-0.62958,-1.65,0.0622,1121,0.376,"amsacrine, irinotecan, genz.644282, dexrazoxane, teniposide, voreloxin, doxorubicin, daunorubicin, mitoxantrone, topotecan, valrubicin, etoposide, amonafide, nemorubicin, etoposide.phosphate, epirubicin",1.20620961530918,0.424812155072339,FALSE +"H520","Pearson.est","tubulin polymerization inhibitor",-0.4619,-1.19,0.281,945,0.74,"epothilone.d, dolastatin.10, mebendazole, vindesine, BNC105, vinorelbine, verubulin, fosbretabulin, vincristine, CYT.997, flubendazole, ABT.751, albendazole, combretastatin.A.4, fenbendazole, taltobulin, KX2.391",0.55129368009492,0.130768280269024,FALSE +"H520","Pearson.est","tyrosine kinase inhibitor",0.32734,0.803,0.69,126,0.975,"dasatinib, vandetanib, BMS.599626",0.161150909262745,0.0109953843014632,FALSE +"H520","Pearson.est","VEGFR inhibitor",0.24002,0.599,0.934,178,1,"vandetanib, XL.647, ZM.306416, SU014813, BMS.690514, lucitanib",0.0296531237699066,0,FALSE +"H520","Pearson.est","vitamin D receptor agonist",0.26865,0.688,0.813,310,0.96,"ercalcitriol, tacalcitol",0.0899094544059319,0.0177287669604316,FALSE +"H460","Pearson.est","EGFR inhibitor",0.18479,0.566,0.918,1188,1,"tucatinib, BMS.690514, canertinib, AZD8931, tyrphostin.AG.494, lapatinib, FERb.033, neratinib, PD.168393, brigatinib, XL.647, poziotinib, icotinib, ARRY.334543, GW.583340, salvianolic.acid.B, osimertinib, gefitinib, erlotinib, dacomitinib, TAK.285, vandetanib, BIBX.1382, WZ8040, CP.724714, afatinib, WZ.3146, rociletinib, AEE788, tyrphostin.AG.1478, CGP.52411, dovitinib, pelitinib, OSI.420, PD.153035, BMS.599626, CUDC.101, BIBU.1361, CNX.2006, WZ.4002, AST.1306",0.0371573187987575,0,FALSE +"H460","Pearson.est","Abl kinase inhibitor",-0.41326,-0.993,0.482,792,0.942,"ponatinib, flumatinib, GZD824, metatinib, tozasertib, nilotinib, KW.2449, bosutinib",0.31695296176115,0.0259490972071227,FALSE +"H460","Pearson.est","acetylcholine receptor agonist",-0.32193,-0.785,0.747,755,1,"tremorine, nicotine, pilocarpine, oxiracetam",0.126679398184601,0,FALSE +"H460","Pearson.est","acetylcholine receptor antagonist",0.4896,1.51,0.065,742,0.561,"diphemanil, darifenacin, iododexetimide, dicycloverine, hyoscyamine, methscopolamine",1.18708664335714,0.251037138743839,FALSE +"H460","Pearson.est","adenosine receptor antagonist",-0.22484,-0.547,0.974,1255,1,"istradefylline",0.0114410431213845,0,FALSE +"H460","Pearson.est","adrenergic receptor agonist",-0.24893,-0.61,0.935,916,1,"lidamidine, midodrine, oxymetazoline, buphenine, clenbuterol",0.0291883891274822,0,FALSE +"H460","Pearson.est","adrenergic receptor antagonist",-0.46215,-1.12,0.339,1247,0.873,"carvedilol, imiloxan, atipamezole, oxprenolol, vincamine",0.469800301796918,0.0589857562944303,FALSE +"H460","Pearson.est","AKT inhibitor",0.19385,0.6,0.919,123,1,"GDC.0068, GSK2110183, MK.2206",0.0366844886138887,0,FALSE +"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.31824,-0.766,0.804,1441,1,"AZD3463",0.0947439512515487,0,FALSE +"H460","Pearson.est","androgen receptor antagonist",-0.40086,-0.974,0.498,712,0.89,"cyproterone.acetate, RU.58841, nilutamide",0.302770657240282,0.0506099933550872,FALSE +"H460","Pearson.est","antioxidant",-0.55753,-1.33,0.122,851,0.598,"rutin, taurine, trolox, chlorogenic.acid, mesna",0.913640169325252,0.223298816011589,FALSE +"H460","Pearson.est","AP inhibitor",-0.39117,-0.926,0.594,635,0.988,"tanshinone.i, birinapant, embelin, LCL.161",0.226213555018806,0.00524305541237188,FALSE +"H460","Pearson.est","ATPase inhibitor",-0.37845,-0.917,0.582,939,0.961,"digitoxin, blebbistatin...., evodiamine, digitoxigenin, NMS.873, digoxin",0.235077015350112,0.0172766123314547,FALSE +"H460","Pearson.est","Aurora kinase inhibitor",-0.63544,-1.53,0.0347,1021,0.324,"MK.8745, tozasertib, barasertib, barasertib.HQPA, CCT129202, MLN.8054, KW.2449, CCT137690, MK.5108, alisertib, GSK1070916, PHA.680632, AMG900, ENMD.2076, danusertib, SNS.314, AT.9283, hesperadin, PF.03814735",1.45967052520913,0.489454989793388,FALSE +"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.54304,-1.33,0.127,1243,0.598,"tedizolid, radezolid, valnemulin",0.896196279044043,0.223298816011589,FALSE +"H460","Pearson.est","bacterial DNA gyrase inhibitor",-0.44114,-1.07,0.389,1438,0.863,"finafloxacin",0.410050398674292,0.0639892042847904,FALSE +"H460","Pearson.est","BCL inhibitor",-0.44563,-1.08,0.347,1396,0.896,"TW.37, gossypol",0.459670525209126,0.0476919903378748,FALSE +"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.41786,-0.998,0.462,792,0.956,"ponatinib, flumatinib, GZD824, metatinib, tozasertib, nilotinib, bosutinib",0.335358024443874,0.0195421077238999,FALSE +"H460","Pearson.est","benzodiazepine receptor agonist",0.26698,0.813,0.687,117,0.931,"CL.218872, indiplon, bentazepam, nefiracetam",0.16304326294045,0.0310503190186574,FALSE +"H460","Pearson.est","bromodomain inhibitor",-0.42727,-1.02,0.432,643,0.92,"OTX015, PFI.1, JQ1...., I.BET.762, bromosporine",0.364516253185088,0.0362121726544447,FALSE +"H460","Pearson.est","calcium channel blocker",-0.51528,-1.27,0.155,1077,0.706,"cinnarazine, carboxyamidotriazole, mibefradil, tetrandrine",0.809668301829709,0.151195298948196,FALSE +"H460","Pearson.est","CC chemokine receptor antagonist",-0.48901,-1.19,0.254,1215,0.761,"ZK811752, SB.225002, navarixin",0.595166283380062,0.118615343229427,FALSE +"H460","Pearson.est","CDK inhibitor",-0.54832,-1.33,0.115,1126,0.598,"BMS.387032, R547, PHA.793887, aminopurvalanol.a, JNJ.7706621, TG.02, kenpaullone, alvocidib, BMS.265246, ribociclib, abemaciclib, AZD5438, palbociclib",0.939302159646388,0.223298816011589,FALSE +"H460","Pearson.est","CHK inhibitor",0.4275,1.27,0.22,215,0.571,"PF.477736, SCH.900776, LY2606368, LY2603618",0.657577319177794,0.243363891754152,FALSE +"H460","Pearson.est","cyclooxygenase inhibitor",-0.34487,-0.834,0.718,1111,1,"tepoxalin, piroxicam, tryptanthrin, ketoprofen, indoprofen, FR.122047",0.1438755557577,0,FALSE +"H460","Pearson.est","cytochrome P450 inhibitor",-0.32168,-0.785,0.773,619,1,"eplerenone, cobicistat, morin, itraconazole",0.111820506081675,0,FALSE +"H460","Pearson.est","DNA alkylating agent",-0.39955,-0.984,0.484,655,0.913,"dianhydrogalactitol, temozolomide, cyclophosphamide, estramustine, carboplatin, satraplatin, TH.302, streptozotocin, melphalan, carmustine, mitomycin.c",0.315154638355588,0.039529222465701,FALSE +"H460","Pearson.est","DNA inhibitor",-0.35353,-0.847,0.685,1290,1,"melphalan, teroxirone, carmustine, oxaliplatin",0.164309428507574,0,FALSE +"H460","Pearson.est","DNA methyltransferase inhibitor",-0.25337,-0.62,0.916,591,1,"disulfiram, fdcyd, azacitidine, RG108, decitabine",0.0381045263321496,0,FALSE +"H460","Pearson.est","DNA polymerase inhibitor",-0.65464,-1.58,0.026,1283,0.303,"foscarnet, trifluridine, idoxuridine",1.58502665202918,0.518557371497695,FALSE +"H460","Pearson.est","DNA synthesis inhibitor",-0.51182,-1.23,0.195,1101,0.711,"artesunate, enocitabine, CB.10.277, floxuridine, mitomycin.c, cyclocytidine, anisomycin",0.709965388637482,0.148130399270234,FALSE +"H460","Pearson.est","dopamine receptor antagonist",-0.40495,-0.982,0.483,1050,0.894,"amisulpride, piperacetazine, domperidone, mesoridazine, sertindole, raclopride, oxiperomide, paliperidone, UH.232....",0.316052869248488,0.0486624812040823,FALSE +"H460","Pearson.est","estrogen receptor agonist",0.27473,0.834,0.692,139,0.969,"estradiol.cypionate, equol, levonorgestrel, ethinyl.estradiol",0.159893905543242,0.0136762229492347,FALSE +"H460","Pearson.est","estrogen receptor antagonist",0.32837,1.01,0.439,4,0.75,"toremifene",0.357535479757879,0.1249387366083,FALSE +"H460","Pearson.est","FGFR inhibitor",0.33102,1.05,0.326,972,0.74,"erdafitinib, lenvatinib, AZD4547, orantinib, nintedanib, lucitanib, dovitinib, MK.2461, regorafenib, PD.173074",0.486782399932061,0.130768280269024,FALSE +"H460","Pearson.est","FLT3 inhibitor",-0.44515,-1.07,0.379,792,0.863,"ponatinib, dovitinib, midostaurin, TG.101348, lestaurtinib, tozasertib, gilteritinib, sunitinib, pacritinib, KW.2449, TG.02, ENMD.2076, quizartinib",0.421360790031928,0.0639892042847904,FALSE +"H460","Pearson.est","glucocorticoid receptor agonist",-0.32852,-0.804,0.729,934,1,"desonide, flumethasone.pivalate, fluticasone.propionate, halcinonide, prednisolone, rimexolone, flumethasone, halobetasol.propionate, fluocinolone.acetonide, ciclesonide, hydrocortisone",0.137272471682025,0,FALSE +"H460","Pearson.est","glutamate receptor antagonist",0.35052,1.08,0.31,945,0.767,"felbamate, CGP.37849, JNJ.16259685, tiletamine, kynurenic.acid, IEM1754, MTPG, LY456236, CPP, latrepirdine, diazooxonorleucine, ACDPP, SIB.1757",0.508638306165727,0.115204636051019,FALSE +"H460","Pearson.est","glycogen synthase kinase inhibitor",-0.22609,-0.556,0.962,946,1,"TWS.119, tideglusib, kenpaullone",0.0168249279621871,0,FALSE +"H460","Pearson.est","growth factor receptor inhibitor",-0.58048,-1.38,0.104,901,0.648,"PHA.848125, lestaurtinib, GSK1904529A, GSK1838705A, danusertib, AZD3463",0.98296666070122,0.188424994129407,FALSE +"H460","Pearson.est","HCV inhibitor",-0.43235,-1.05,0.399,1217,0.892,"narlaprevir, mericitabine",0.399027104313252,0.0496351456238769,FALSE +"H460","Pearson.est","HDAC inhibitor",-0.21266,-0.512,0.98,574,0.993,"RGFP966, scriptaid, R306465, resminostat, romidepsin, JNJ.26481585, belinostat, trichostatin.a, AR.42, PCI.24781, RG2833, entinostat, givinostat, SB.939, dacinostat",0.00877392430750515,0.00305075150461883,FALSE +"H460","Pearson.est","histamine receptor antagonist",-0.21489,-0.523,0.983,763,1,"levocetirizine, nizatidine, terfenadine, zolantidine, astemizole, BF2.649, pheniramine, tiotidine",0.00744648216786438,0,FALSE +"H460","Pearson.est","HMGCR inhibitor",0.55687,1.7,0.0521,645,0.509,"pitavastatin, lovastatin, atorvastatin, mevastatin, fluvastatin, simvastatin",1.28316227670048,0.293282217663241,FALSE +"H460","Pearson.est","HSP inhibitor",-0.49358,-1.18,0.264,1207,0.757,"ganetespib, SNX.2112, NVP.AUY922, tanespimycin, PU.H71",0.578396073130169,0.120904120499927,FALSE +"H460","Pearson.est","JAK inhibitor",-0.43913,-1.04,0.423,1041,0.89,"tozasertib, AZD1480, pacritinib, AZ960, WHI.P154, TG.101209, TG.02, AT.9283, filgotinib",0.373659632624958,0.0506099933550872,FALSE +"H460","Pearson.est","KIT inhibitor",-0.31204,-0.755,0.82,1151,1,"OSI.930, sunitinib, vatalanib, KI.8751",0.0861861476162833,0,FALSE +"H460","Pearson.est","MDM inhibitor",-0.73615,-1.81,0.00224,1170,0.0784,"RITA, idasanutlin, CGM097, serdemetan, nutlin.3",2.64975198166584,1.10568393731556,TRUE +"H460","Pearson.est","MEK inhibitor",-0.77946,-1.91,0,1195,0.0811,"arctigenin, cobimetinib, refametinib, PD.198306, MEK162, trametinib, PD.184352, selumetinib, AS.703026, nobiletin, PD.318088, PD.0325901, TAK.733, AZD8330, Ro.4987655",Inf,1.09097914578884,TRUE +"H460","Pearson.est","MET inhibitor",0.46325,1.47,0.0696,780,0.439,"INC.280, NVP.BVU972, AMG458, PF.04217903, LY2801653, PHA.665752",1.15739076038944,0.357535479757879,FALSE +"H460","Pearson.est","microtubule inhibitor",-0.71337,-1.72,0.00682,1275,0.148,"cabazitaxel, secnidazole, vinflunine, D.64131, vinblastine, podophyllotoxin",2.16621562534352,0.829738284605043,TRUE +"H460","Pearson.est","mTOR inhibitor",-0.40351,-0.987,0.497,737,0.932,"palomid.529, torin.2, WYE.125132, voxtalisib, SB.2343, PKI.179, deforolimus, LY303511, GSK2126458, NVP.BEZ235, AZD2014, PP242, WAY.600, AZD8055, MLN0128, XL388, torin.1, WYE.354, ku.0063794",0.303643611266668,0.0305840876460186,FALSE +"H460","Pearson.est","NFkB pathway inhibitor",-0.21219,-0.509,0.977,719,0.979,"Ro.106.9920, parthenolide, bortezomib, betulinic.acid, EVP4593",0.0101054362812269,0.00921730819686218,FALSE +"H460","Pearson.est","opioid receptor agonist",-0.55926,-1.37,0.101,950,0.622,"spiradoline, cebranopadol, salvinorin.a, trimebutine",0.995678626217357,0.206209615309181,FALSE +"H460","Pearson.est","p38 MAPK inhibitor",0.32824,0.98,0.471,975,0.738,"talmapimod, SB.239063, TAK.715, SB.242235, VX.702, CMPD.1, skepinone.l",0.326979092871104,0.131943638176958,FALSE +"H460","Pearson.est","PARP inhibitor",-0.51074,-1.24,0.186,908,0.72,"AZD2461, niraparib, PJ.34, AG.14361, E7449, talazoparib",0.730487055782084,0.142667503568732,FALSE +"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.25466,-0.615,0.93,742,1,"axitinib, ponatinib, trapidil, dovitinib, regorafenib, CP.673451, SU014813, sunitinib, vatalanib, crenolanib, KI.8751",0.0315170514460649,0,FALSE +"H460","Pearson.est","phosphatase inhibitor",0.14882,0.434,1,1234,0.995,"menadione, alexidine, BVT.948, AS.1949490, mycophenolate.mofetil, CID.5458317, bis.maltolato.oxovanadium.IV., sodium.stibogluconate, mycophenolic.acid, GSK2830371",0,0.00217691925427455,FALSE +"H460","Pearson.est","phosphodiesterase inhibitor",0.20376,0.638,0.965,1155,1,"enoximone, trequinsin, avanafil, anagrelide, cilostamide, papaverine, YM.976, zardaverine, GSK256066, EMD.53998",0.0154726866562074,0,FALSE +"H460","Pearson.est","PI3K inhibitor",-0.24808,-0.599,0.934,764,1,"BGT226, voxtalisib, GDC.0941, SB.2343, TG.100713, PKI.179, LY303511, GSK2126458, CUDC.907, NVP.BEZ235, YM.201636, PIK.75, ZSTK.474",0.0296531237699066,0,FALSE +"H460","Pearson.est","PLK inhibitor",-0.75156,-1.85,0.00554,1083,0.0797,"GW.843682X, BI.2536, NMS.1286937, GSK461364, HMN.214, volasertib, rigosertib",2.25649023527157,1.09854167860389,TRUE +"H460","Pearson.est","potassium channel blocker",-0.33703,-0.821,0.732,486,1,"dofetilide, meglitinide, mepivacaine, ibutilide, ML133, oleoylethanolamide",0.135488918941608,0,FALSE +"H460","Pearson.est","PPAR receptor agonist",-0.23955,-0.58,0.944,1015,1,"ciprofibrate, oleoylethanolamide",0.025028005701931,0,FALSE +"H460","Pearson.est","progesterone receptor agonist",-0.26975,-0.667,0.892,953,1,"dienogest, melengestrol.acetate, tanaproget",0.0496351456238769,0,FALSE +"H460","Pearson.est","proteasome inhibitor",0.39375,1.2,0.224,881,0.602,"delanzomib, ONX.0914, oprozomib, carfilzomib, ixazomib.citrate, MG.132, bortezomib, ixazomib",0.649751981665837,0.220403508742175,FALSE +"H460","Pearson.est","protein synthesis inhibitor",-0.63246,-1.55,0.0355,1285,0.324,"emetine, brefeldin.a, mercaptopurine, harringtonine, anguidine, bruceantin, cycloheximide, homoharringtonine",1.44977164694491,0.489454989793388,FALSE +"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.33269,-0.802,0.741,888,1,"mubritinib, BMS.599626, tyrphostin.A9, NVP.TAE226",0.130181792020672,0,FALSE +"H460","Pearson.est","RAF inhibitor",-0.50483,-1.24,0.201,1105,0.72,"SB.590885, CEP.32496, RAF265, dabrafenib, LGX818, AZ.628, GDC.0879",0.696803942579511,0.142667503568732,FALSE +"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.34496,-0.836,0.705,873,1,"regorafenib, cabozantinib, sunitinib",0.151810883008601,0,FALSE +"H460","Pearson.est","retinoid receptor agonist",-0.35923,-0.87,0.655,1392,1,"adarotene",0.183758700008217,0,FALSE +"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.44285,-1.08,0.369,924,0.896,"gemcitabine, cladribine, triapine, clofarabine, LY2334737",0.43297363384094,0.0476919903378748,FALSE +"H460","Pearson.est","serotonin receptor agonist",-0.53638,-1.3,0.123,1447,0.652,"aripiprazole",0.910094888560602,0.18575240426808,FALSE +"H460","Pearson.est","serotonin receptor antagonist",-0.44652,-1.08,0.356,1068,0.896,"pirenperone, sertindole, paliperidone, SB.200646, aripiprazole",0.448550002027125,0.0476919903378748,FALSE +"H460","Pearson.est","sodium channel blocker",-0.38465,-0.923,0.591,1013,0.971,"triamterene, butamben, mexiletine, benzethonium, ajmaline, A.803467",0.228412519118745,0.0127807700919951,FALSE +"H460","Pearson.est","src inhibitor",-0.46449,-1.12,0.321,1133,0.873,"KX2.391, PP.2, TG.100572, bosutinib",0.493494967595128,0.0589857562944303,FALSE +"H460","Pearson.est","sterol demethylase inhibitor",-0.30791,-0.75,0.793,444,1,"posaconazole, chlormidazole, sulconazole, terconazole, lanoconazole, ketoconazole",0.100726812682396,0,FALSE +"H460","Pearson.est","TGF beta receptor inhibitor",0.42926,1.33,0.149,829,0.575,"LY2109761, SB.431542, repsox, D.4476, SB.525334, adaprev",0.826813731587726,0.24033215531037,FALSE +"H460","Pearson.est","thymidylate synthase inhibitor",-0.61761,-1.5,0.0411,1141,0.351,"ftorafur, trifluridine, raltitrexed, carmofur",1.38615817812393,0.454692883534176,FALSE +"H460","Pearson.est","topoisomerase inhibitor",-0.50043,-1.2,0.243,833,0.767,"irinotecan, nemorubicin, doxorubicin, camptothecin, SN.38, topotecan, exatecan.mesylate, fleroxacin, dexrazoxane, rubitecan, valrubicin, genz.644282, daunorubicin, voreloxin, teniposide, amonafide, idarubicin, amsacrine, TAS.103",0.614393726401688,0.115204636051019,FALSE +"H460","Pearson.est","tubulin polymerization inhibitor",-0.66396,-1.59,0.0233,1027,0.338,"mebendazole, oxibendazole, paclitaxel, KX2.391, vindesine, indibulin, vincristine, plinabulin, nocodazole, CYT.997, docetaxel, ABT.751, BNC105, vinorelbine, vinblastine, dolastatin.10, podophyllotoxin, parbendazole, combretastatin.A.4, albendazole, taltobulin, verubulin, epothilone.b, fosbretabulin",1.63264407897398,0.471083299722345,FALSE +"H460","Pearson.est","tyrosine kinase inhibitor",-0.2958,-0.717,0.819,873,1,"regorafenib, mubritinib, BMS.599626, cabozantinib, tyrphostin.A9, UNC2250, tivantinib, sunitinib, aminopurvalanol.a, NVP.TAE226",0.0867160982395816,0,FALSE +"H460","Pearson.est","VEGFR inhibitor",-0.2665,-0.644,0.92,817,1,"dovitinib, MK.2461, regorafenib, semaxanib, PD.173074, cabozantinib, SU014813, SAR131675, OSI.930, sunitinib, RAF265, vatalanib, TG.100572, ENMD.2076, KI.8751",0.0362121726544447,0,FALSE +"H460","Pearson.est","vitamin D receptor agonist",-0.35484,-0.852,0.677,847,1,"alfacalcidol, doxercalciferol, tacalcitol, ercalcitriol",0.169411331314856,0,FALSE +"H1299","Pearson.est","EGFR inhibitor",0.8326,2.35,0,121,0.0105,"AZD8931, poziotinib, XL.647, canertinib, neratinib, gefitinib, lapatinib, BMS.690514, dacomitinib, osimertinib, erlotinib, tucatinib, ARRY.334543, afatinib, vandetanib, BMS.599626, PD.168393, CUDC.101, icotinib, WZ8040, AST.1306, pelitinib, BIBU.1361, PD.153035, CP.724714, AEE788, rociletinib, WZ.4002, GW.583340",Inf,1.97881070093006,TRUE +"H1299","Pearson.est","Abl kinase inhibitor",-0.32189,-0.752,0.804,998,1,"ponatinib, flumatinib, nilotinib, KW.2449, tozasertib, GZD824",0.0947439512515487,0,FALSE +"H1299","Pearson.est","acetylcholine receptor agonist",-0.4728,-1.12,0.317,1189,0.73,"xanomeline, oxiracetam",0.498940737782249,0.136677139879544,FALSE +"H1299","Pearson.est","acetylcholine receptor antagonist",-0.4804,-1.12,0.329,1151,0.73,"methscopolamine, iododexetimide",0.482804102050026,0.136677139879544,FALSE +"H1299","Pearson.est","adenosine receptor antagonist",0.64509,1.76,0.00909,122,0.156,"CGS.15943, MRS.1220, SCH.58261, PSB.1115",2.04143611677803,0.806875401645538,TRUE +"H1299","Pearson.est","adrenergic receptor agonist",0.2568,0.734,0.824,1080,1,"isoxsuprine, methyldopa, oxymetazoline, isoetharine, ritodrine, norepinephrine, metaraminol, epinephrine, terbutaline, xylazine, A61603, clenbuterol, buphenine, lidamidine, midodrine",0.0840727883028842,0,FALSE +"H1299","Pearson.est","adrenergic receptor antagonist",-0.34419,-0.799,0.735,868,1,"pindolol, naftidrofuryl, metoprolol, oxprenolol, atipamezole, vincamine, idazoxan, carvedilol",0.133712660915805,0,FALSE +"H1299","Pearson.est","AKT inhibitor",0.46108,1.34,0.146,243,0.356,"GDC.0068, uprosertib, CCT128930, GSK2110183, AZD5363, triciribine",0.835647144215563,0.448550002027125,FALSE +"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.26514,0.741,0.796,1067,1,"GW.788388, brigatinib, SB.505124, NVP.TAE684, CEP.37440, alectinib, AP26113, AZD3463, crizotinib, DMH1, lorlatinib",0.0990869322623309,0,FALSE +"H1299","Pearson.est","androgen receptor antagonist",-0.26972,-0.638,0.913,551,0.952,"cyproterone.acetate, RU.58841, bicalutamide, flutamide, nilutamide",0.039529222465701,0.0213630516155257,FALSE +"H1299","Pearson.est","antioxidant",0.53883,1.49,0.0708,671,0.301,"mesna, taurine, trolox, rutin, chlorogenic.acid, benfotiamine",1.14996674231023,0.521433504406157,FALSE +"H1299","Pearson.est","AP inhibitor",-0.51716,-1.22,0.224,1012,0.668,"birinapant, GDC.0152, idronoxil",0.649751981665837,0.175223537524454,FALSE +"H1299","Pearson.est","ATPase inhibitor",-0.71887,-1.69,0.0193,1165,0.122,"evodiamine, digitoxin, ouabain, k.strophanthidin, thonzonium, NMS.873, digitoxigenin, oligomycin.a, digoxin",1.71444269099223,0.913640169325252,TRUE +"H1299","Pearson.est","Aurora kinase inhibitor",-0.64737,-1.55,0.0259,1167,0.31,"ZM.447439, GSK1070916, alisertib, KW.2449, tozasertib, MK.8745, barasertib.HQPA, hesperadin, CCT137690, AT.9283, barasertib, PF.03814735, MK.5108, AMG900, SNS.314, danusertib",1.58670023591875,0.508638306165727,FALSE +"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.30244,-0.703,0.847,940,0.993,"josamycin, radezolid, valnemulin",0.0721165896692931,0.00305075150461883,FALSE +"H1299","Pearson.est","bacterial DNA gyrase inhibitor",-0.31494,-0.749,0.783,702,1,"sparfloxacin, trovafloxacin, sarafloxacin, norfloxacin, lomefloxacin, novobiocin",0.106238237942057,0,FALSE +"H1299","Pearson.est","BCL inhibitor",-0.4493,-1.05,0.419,1229,0.861,"TW.37, gossypol",0.377785977033705,0.0649968485463452,FALSE +"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.37134,-0.875,0.653,998,1,"ponatinib, flumatinib, nilotinib, tozasertib, GZD824",0.185086818724926,0,FALSE +"H1299","Pearson.est","benzodiazepine receptor agonist",0.22997,0.661,0.859,1118,1,"CL.218872, gamma.aminobutyric.acid, nefiracetam, piperazine, eprinomectin, lorazepam, zaleplon, bentazepam, CGS.20625, indiplon, ZK.93423, ivermectin, temazepam",0.0660068361687577,0,FALSE +"H1299","Pearson.est","bromodomain inhibitor",-0.3536,-0.825,0.688,634,1,"I.BET151, OTX015, PFI.1, bromosporine",0.162411561764489,0,FALSE +"H1299","Pearson.est","calcium channel blocker",-0.33053,-0.765,0.746,1423,1,"carboxyamidotriazole",0.127261172527331,0,FALSE +"H1299","Pearson.est","CC chemokine receptor antagonist",-0.60278,-1.4,0.0927,913,0.507,"RS.504393, PF.04136309, MK.0812, SB.225002, UNBS.5162",1.0329202658555,0.294992040666664,FALSE +"H1299","Pearson.est","CDK inhibitor",-0.33829,-0.795,0.743,880,1,"JNJ.7706621, AZD5438, kenpaullone, palbociclib, dinaciclib, R547, PHA.848125, BMS.265246, BMS.387032, indisulam, abemaciclib, PHA.793887",0.129011186239425,0,FALSE +"H1299","Pearson.est","CHK inhibitor",-0.43828,-1.03,0.442,1191,0.884,"LY2606368, PF.477736",0.354577730650908,0.0535477349869269,FALSE +"H1299","Pearson.est","cyclooxygenase inhibitor",-0.30549,-0.725,0.813,1096,1,"indoprofen, piroxicam, AM.404, naproxen, suxibuzone, tepoxalin",0.0899094544059319,0,FALSE +"H1299","Pearson.est","cytochrome P450 inhibitor",-0.38331,-0.895,0.613,929,1,"clotrimazole, cobicistat, metyrapone",0.212539525481585,0,FALSE +"H1299","Pearson.est","DNA alkylating agent",-0.38587,-0.904,0.615,904,1,"streptozotocin, estramustine, cisplatin, carboplatin, TH.302, dianhydrogalactitol, satraplatin, melphalan",0.211124884224583,0,FALSE +"H1299","Pearson.est","DNA inhibitor",-0.38573,-0.908,0.577,1338,1,"valrubicin, melphalan, chlorambucil",0.238824186844269,0,FALSE +"H1299","Pearson.est","DNA methyltransferase inhibitor",0.24649,0.701,0.825,184,1,"azacitidine, fdcyd",0.0835460514500749,0,FALSE +"H1299","Pearson.est","DNA polymerase inhibitor",-0.41626,-0.965,0.52,1159,1,"trifluridine, idoxuridine, cephalomannine",0.283996656365201,0,FALSE +"H1299","Pearson.est","DNA synthesis inhibitor",-0.52826,-1.22,0.215,981,0.668,"nelarabine, azodicarbonamide, cyclocytidine, artesunate, enocitabine, cisplatin, CB.10.277, artemisinin, anisomycin",0.667561540084395,0.175223537524454,FALSE +"H1299","Pearson.est","dopamine receptor antagonist",0.21578,0.617,0.916,264,1,"lurasidone, clebopride, domperidone, ziprasidone, remoxipride, acetophenazine, nemonapride, mesoridazine, oxiperomide",0.0381045263321496,0,FALSE +"H1299","Pearson.est","estrogen receptor agonist",0.29792,0.83,0.668,1019,1,"levonorgestrel, erteberel, ethinyl.estradiol, equol, estradiol.cypionate, PPT, estradiol, estrone",0.175223537524454,0,FALSE +"H1299","Pearson.est","estrogen receptor antagonist",-0.39952,-0.941,0.537,1139,1,"fulvestrant, toremifene",0.270025714300444,0,FALSE +"H1299","Pearson.est","FGFR inhibitor",-0.50765,-1.19,0.246,1048,0.69,"MK.2461, dovitinib, nintedanib, erdafitinib, regorafenib",0.609064892896621,0.161150909262745,FALSE +"H1299","Pearson.est","FLT3 inhibitor",-0.49502,-1.17,0.272,998,0.715,"ponatinib, lestaurtinib, TG.101348, dovitinib, KW.2449, tyrphostin.AG.1296, tozasertib, midostaurin, quizartinib, sorafenib",0.565431095965801,0.145693958198919,FALSE +"H1299","Pearson.est","glucocorticoid receptor agonist",0.15179,0.417,0.991,1232,0.998,"triamcinolone.acetonide, ciclesonide, fludroxycortide, hydrocortisone, desonide, methylprednisolone, betamethasone, difluprednate, flumethasone.pivalate, dexamethasone.acetate, fluocinolone.acetonide, clobetasol.propionate, flumethasone, piretanide, prednisolone.acetate, triamcinolone, halobetasol.propionate, halcinonide, prednisolone, prednisolone.hemisuccinate, beclomethasone.dipropionate, rimexolone, deflazacort, fluticasone.propionate, fluorometholone",0.00392634551472468,0.000869458712628891,FALSE +"H1299","Pearson.est","glutamate receptor antagonist",0.42771,1.21,0.204,164,0.488,"diazooxonorleucine, latrepirdine, CGP.37849, kynurenic.acid, SIB.1757",0.690369832574101,0.311580177997289,FALSE +"H1299","Pearson.est","glycogen synthase kinase inhibitor",-0.27844,-0.66,0.882,926,0.983,"GSK.3.inhibitor.IX, TWS.119, kenpaullone, AZD2858, tideglusib",0.0545314148681803,0.00744648216786438,FALSE +"H1299","Pearson.est","growth factor receptor inhibitor",-0.36841,-0.873,0.649,927,1,"GSK1838705A, PHA.848125, lestaurtinib, danusertib",0.187755303199631,0,FALSE +"H1299","Pearson.est","HCV inhibitor",-0.65176,-1.53,0.0424,1138,0.314,"Ro.9187, mericitabine, narlaprevir",1.37263414340727,0.503070351926785,FALSE +"H1299","Pearson.est","HDAC inhibitor",-0.30694,-0.727,0.814,760,1,"R306465, ACY.1215, SB.939, trichostatin.a, givinostat, RG2833, AR.42, resminostat, scriptaid, chidamide, dacinostat, entinostat, belinostat",0.0893755951107988,0,FALSE +"H1299","Pearson.est","histamine receptor antagonist",-0.21575,-0.51,0.976,1180,0.994,"nizatidine, tiotidine, cimetidine",0.0105501823333082,0.00261361560268669,FALSE +"H1299","Pearson.est","HMGCR inhibitor",-0.84377,-2,0.00124,1408,0.0212,"pitavastatin, fluvastatin, mevastatin, atorvastatin",2.90657831483776,1.67366413907125,TRUE +"H1299","Pearson.est","HSP inhibitor",-0.64908,-1.52,0.052,1247,0.3,"BIIB021, PU.H71, ganetespib, SNX.2112, NVP.AUY922, NMS.E973",1.2839966563652,0.522878745280338,FALSE +"H1299","Pearson.est","JAK inhibitor",-0.36124,-0.849,0.67,1039,1,"lestaurtinib, TG.101348, AZ960, PRT062070, tozasertib, AT.9283",0.173925197299174,0,FALSE +"H1299","Pearson.est","KIT inhibitor",-0.5337,-1.25,0.191,1107,0.656,"cediranib, OSI.930, motesanib, vatalanib, midostaurin, sorafenib, KI.8751, regorafenib, pazopanib",0.718966632752272,0.18309616062434,FALSE +"H1299","Pearson.est","MDM inhibitor",-0.28205,-0.657,0.882,1222,0.968,"serdemetan",0.0545314148681803,0.0141246426916063,FALSE +"H1299","Pearson.est","MEK inhibitor",0.66475,2.05,0.00518,168,0.0514,"trametinib, AS.703026, selumetinib, cobimetinib, AZD8330, PD.0325901, TAK.733, Ro.4987655, MEK162, PD.318088, PD.198306, MEK1.2.inhibitor",2.28567024025477,1.28903688100472,TRUE +"H1299","Pearson.est","MET inhibitor",-0.2762,-0.647,0.903,955,0.96,"AMG458, PHA.665752, LY2801653",0.0443122496864942,0.0177287669604316,FALSE +"H1299","Pearson.est","microtubule inhibitor",-0.72772,-1.7,0.00855,1273,0.133,"D.64131, podophyllotoxin, secnidazole, cabazitaxel, vinflunine, vinblastine",2.06803388527183,0.876148359032914,TRUE +"H1299","Pearson.est","mTOR inhibitor",0.16318,0.456,1,1022,1,"GSK2126458, GDC.0980, LY303511, WYE.125132, voxtalisib, WAY.600, PP242, XL388, PI.103, OSI.027, torin.2, PF.04691502, SB.2343, everolimus, WYE.354, palomid.529, AZD2014, torin.1, AZD8055, temsirolimus, PF.05212384, MLN0128, NVP.BEZ235, ku.0063794, sirolimus, PKI.179, LY3023414",0,0,FALSE +"H1299","Pearson.est","NFkB pathway inhibitor",-0.32517,-0.773,0.786,613,1,"curcumin, parthenolide...., bindarit, BAY.11.7082, betulinic.acid, bortezomib, parthenolide, IKK.2.inhibitor.V, EVP4593",0.104577453960592,0,FALSE +"H1299","Pearson.est","opioid receptor agonist",-0.39109,-0.916,0.587,754,1,"salvinorin.a, trimebutine, cebranopadol, spiradoline",0.231361898752386,0,FALSE +"H1299","Pearson.est","p38 MAPK inhibitor",0.47606,1.39,0.0878,762,0.328,"SB.239063, talmapimod, SB.242235, TAK.715, skepinone.l, VX.702, CMPD.1",1.0565054840939,0.484126156288321,FALSE +"H1299","Pearson.est","PARP inhibitor",-0.49206,-1.15,0.303,728,0.707,"PJ.34, niraparib, AG.14361, E7449, olaparib, AZD2461, talazoparib",0.518557371497695,0.150580586203101,FALSE +"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.55223,-1.3,0.145,1131,0.588,"trapidil, motesanib, SU014813, dovitinib, nintedanib, vatalanib, axitinib, crenolanib, CP.673451, sorafenib, KI.8751, regorafenib, pazopanib",0.838631997765025,0.230622673923862,FALSE +"H1299","Pearson.est","phosphatase inhibitor",-0.40347,-0.925,0.587,935,1,"AS.1949490, BVT.948, CID.5458317, GSK2830371, bis.maltolato.oxovanadium.IV.",0.231361898752386,0,FALSE +"H1299","Pearson.est","phosphodiesterase inhibitor",-0.28672,-0.68,0.864,962,0.982,"papaverine, zardaverine, YM.976, GSK256066",0.0634862575211067,0.00788851221305034,FALSE +"H1299","Pearson.est","PI3K inhibitor",0.32666,0.883,0.553,92,1,"alpelisib, taselisib, GSK2126458, CH5132799, PI.828",0.257274868695302,0,FALSE +"H1299","Pearson.est","PLK inhibitor",-0.81124,-1.88,0.00124,1169,0.0515,"GW.843682X, HMN.214, GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib",2.90657831483776,1.28819277095881,TRUE +"H1299","Pearson.est","potassium channel blocker",-0.50625,-1.19,0.245,850,0.69,"ibutilide, meglitinide, mepivacaine, dofetilide",0.610833915635468,0.161150909262745,FALSE +"H1299","Pearson.est","PPAR receptor agonist",-0.35854,-0.833,0.71,809,1,"ciprofibrate, clofibrate, GW.501516",0.148741651280925,0,FALSE +"H1299","Pearson.est","progesterone receptor agonist",-0.18348,-0.435,0.994,799,0.994,"norgestrel, norethindrone, dienogest, tanaproget",0.00261361560268669,0.00261361560268669,FALSE +"H1299","Pearson.est","proteasome inhibitor",-0.59536,-1.38,0.0978,967,0.522,"bortezomib, ONX.0914, delanzomib, carfilzomib, ixazomib, MG.132",1.0096611452124,0.282329496997738,FALSE +"H1299","Pearson.est","protein synthesis inhibitor",-0.56802,-1.34,0.131,1206,0.515,"puromycin, cycloheximide, bruceantin, thiostrepton, harringtonine, mercaptopurine, homoharringtonine, anguidine",0.882728704344236,0.288192770958809,FALSE +"H1299","Pearson.est","protein tyrosine kinase inhibitor",0.42594,1.19,0.219,72,0.473,"BMS.599626, AV.412, CP.724714",0.659555885159882,0.325138859262188,FALSE +"H1299","Pearson.est","RAF inhibitor",-0.58449,-1.37,0.116,1250,0.508,"TAK.632, PLX.4720, RAF265, sorafenib, regorafenib",0.935542010773082,0.294136287716081,FALSE +"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.45537,-1.06,0.406,1345,0.866,"sorafenib, regorafenib",0.391473966422806,0.0624821079826534,FALSE +"H1299","Pearson.est","retinoid receptor agonist",0.31621,0.873,0.607,61,1,"CD.437, tamibarotene",0.216811308924742,0,FALSE +"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.59692,-1.41,0.0929,1302,0.527,"triapine, pentostatin, gemcitabine, cladribine, clofarabine",1.03198428600636,0.278189384787453,FALSE +"H1299","Pearson.est","serotonin receptor agonist",-0.55047,-1.28,0.185,1305,0.609,"pardoprunox, aripiprazole",0.732828271596986,0.215382707367125,FALSE +"H1299","Pearson.est","serotonin receptor antagonist",-0.49817,-1.16,0.289,1316,0.71,"paliperidone, lerisetron, aripiprazole",0.539102157243452,0.148741651280925,FALSE +"H1299","Pearson.est","sodium channel blocker",-0.5799,-1.36,0.138,971,0.496,"quinidine, mepivacaine, butamben, brivaracetam, triamterene, cibenzoline, benzethonium",0.860120913598763,0.304518323509803,FALSE +"H1299","Pearson.est","src inhibitor",0.62004,1.74,0.0249,41,0.134,"saracatinib, dasatinib, ZM.306416",1.60380065290426,0.872895201635192,TRUE +"H1299","Pearson.est","sterol demethylase inhibitor",-0.30205,-0.712,0.834,738,1,"lanoconazole, ketoconazole, posaconazole, chlormidazole",0.0788339493622613,0,FALSE +"H1299","Pearson.est","TGF beta receptor inhibitor",0.51299,1.43,0.0931,227,0.317,"repsox, LY2109761, SB.431542",1.03105031901866,0.498940737782249,FALSE +"H1299","Pearson.est","thymidylate synthase inhibitor",-0.27336,-0.636,0.894,664,0.937,"ftorafur, doxifluridine, raltitrexed, trifluridine",0.0486624812040823,0.0282604091122217,FALSE +"H1299","Pearson.est","topoisomerase inhibitor",-0.79476,-1.84,0.0025,1234,0.05,"genz.644282, amonafide, dexrazoxane, amsacrine, SN.38, nemorubicin, valrubicin, idarubicin, irinotecan, mitoxantrone, voreloxin, doxorubicin, epirubicin, TAS.103, rubitecan, etoposide, etoposide.phosphate, daunorubicin, teniposide, topotecan",2.60205999132796,1.30102999566398,TRUE +"H1299","Pearson.est","tubulin polymerization inhibitor",-0.77033,-1.82,0.00854,1175,0.0513,"parbendazole, mebendazole, epothilone.d, epothilone.b, albendazole, fenbendazole, plinabulin, fosbretabulin, ABT.751, dolastatin.10, podophyllotoxin, vinorelbine, KX2.391, CYT.997, paclitaxel, docetaxel, combretastatin.A.4, vincristine, vindesine, verubulin, taltobulin, BNC105, vinblastine",2.068542129311,1.28988263488818,TRUE +"H1299","Pearson.est","tyrosine kinase inhibitor",0.26174,0.74,0.807,72,1,"vandetanib, BMS.599626, dasatinib, AV.412, CP.724714",0.0931264652779296,0,FALSE +"H1299","Pearson.est","VEGFR inhibitor",-0.2861,-0.682,0.869,1048,0.998,"MK.2461, SAR131675, cediranib, OSI.930, motesanib, SU014813, dovitinib, nintedanib, vatalanib, tivozanib, axitinib, RAF265, sorafenib, KI.8751, regorafenib, pazopanib",0.0609802235513335,0.000869458712628891,FALSE +"H1299","Pearson.est","vitamin D receptor agonist",0.73963,2.15,0,144,0.0363,"maxacalcitol, paricalcitol, tacalcitol",Inf,1.44009337496389,TRUE +"HCC44","Pearson.est","EGFR inhibitor",-0.74153,-1.74,0.00917,1369,0.257,"WZ.4002, PD.168393, BMS.690514, BMS.599626, CUDC.101, icotinib, BIBU.1361, vandetanib, canertinib, lapatinib, PD.153035, osimertinib, neratinib, AST.1306, AZD8931, dacomitinib, pelitinib, gefitinib, afatinib, erlotinib, XL.647, poziotinib",2.03763066432998,0.590066876668705,FALSE +"HCC44","Pearson.est","Abl kinase inhibitor",-0.60626,-1.4,0.106,1396,0.58,"ZM.306416, bosutinib, dasatinib",0.97469413473523,0.236572006437063,FALSE +"HCC44","Pearson.est","acetylcholine receptor agonist",0.19626,0.54,0.956,1165,0.971,"nefiracetam, xanomeline, oxiracetam, nicotine, tremorine, pilocarpine",0.0195421077238999,0.0127807700919951,FALSE +"HCC44","Pearson.est","acetylcholine receptor antagonist",0.51275,1.45,0.0855,347,0.906,"diphemanil, iododexetimide, darifenacin, methscopolamine",1.06803388527183,0.0428718023231869,FALSE +"HCC44","Pearson.est","adenosine receptor antagonist",-0.63517,-1.49,0.0571,1352,0.582,"PSB.1115, CGS.15943",1.24336389175415,0.235077015350112,FALSE +"HCC44","Pearson.est","adrenergic receptor agonist",-0.29171,-0.672,0.874,1217,1,"isoxsuprine, ritodrine, oxymetazoline",0.058488567365597,0,FALSE +"HCC44","Pearson.est","adrenergic receptor antagonist",-0.21931,-0.515,0.965,922,1,"atenolol......, idazoxan, vincamine, atipamezole, naftidrofuryl, imiloxan, dronedarone",0.0154726866562074,0,FALSE +"HCC44","Pearson.est","AKT inhibitor",-0.41692,-0.962,0.515,953,0.893,"palomid.529, uprosertib, AZD5363, AT7867, triciribine",0.288192770958809,0.0491485411114536,FALSE +"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.37021,-0.86,0.668,822,1,"alectinib, lorlatinib, SB.505124, GW.788388, AP26113, AZD3463",0.175223537524454,0,FALSE +"HCC44","Pearson.est","androgen receptor antagonist",0.24856,0.711,0.824,237,1,"flutamide, enzalutamide",0.0840727883028842,0,FALSE +"HCC44","Pearson.est","antioxidant",-0.5485,-1.28,0.191,1398,0.542,"mesna",0.718966632752272,0.266000713461613,FALSE +"HCC44","Pearson.est","AP inhibitor",0.25515,0.725,0.811,68,1,"idronoxil",0.090979145788844,0,FALSE +"HCC44","Pearson.est","ATPase inhibitor",0.32566,0.894,0.546,183,1,"oligomycin.a, omeprazole, rabeprazole",0.262807357295263,0,FALSE +"HCC44","Pearson.est","Aurora kinase inhibitor",-0.31183,-0.716,0.815,968,1,"hesperadin, CCT129202, MK.5108, danusertib, ENMD.2076, alisertib, CYC116, PHA.680632, GSK1070916",0.0888423912600234,0,FALSE +"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.58114,-1.36,0.124,912,0.647,"dirithromycin, azalomycin.b, azithromycin, tilmicosin, radezolid, valnemulin, tedizolid",0.906578314837765,0.1890957193313,FALSE +"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.45392,-1.08,0.358,1422,0.885,"finafloxacin",0.446116973356126,0.0530567293021746,FALSE +"HCC44","Pearson.est","BCL inhibitor",0.39765,1.09,0.286,116,0.836,"oridonin, ABT.737, HA14.1",0.543633966870957,0.0777937225609836,FALSE +"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.55572,-1.31,0.137,1407,0.561,"bosutinib, dasatinib",0.863279432843593,0.251037138743839,FALSE +"HCC44","Pearson.est","benzodiazepine receptor agonist",-0.23279,-0.544,0.957,961,1,"CGS.20625, zaleplon, ZK.93423, eprinomectin, lorazepam, ivermectin",0.0190880622231565,0,FALSE +"HCC44","Pearson.est","bromodomain inhibitor",0.30236,0.855,0.61,1012,0.99,"PFI.1, I.BET151, OTX015, I.BET.762, bromosporine, JQ1....",0.214670164989233,0.00436480540245009,FALSE +"HCC44","Pearson.est","calcium channel blocker",-0.44882,-1.06,0.389,1228,0.901,"SKF.96365, cinnarazine, tetrandrine",0.410050398674292,0.045275209020937,FALSE +"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.43962,-1.02,0.426,1337,0.903,"navarixin, ZK811752",0.370590400897281,0.0443122496864942,FALSE +"HCC44","Pearson.est","CDK inhibitor",-0.57439,-1.33,0.149,1116,0.547,"BMS.387032, kenpaullone, palbociclib, PHA.848125, P276.00, BMS.265246, JNJ.7706621, aminopurvalanol.a, AT.7519, alvocidib, AZD5438",0.826813731587726,0.262012673666569,FALSE +"HCC44","Pearson.est","CHK inhibitor",0.23084,0.64,0.91,62,0.971,"PF.477736",0.0409586076789064,0.0127807700919951,FALSE +"HCC44","Pearson.est","cyclooxygenase inhibitor",0.30121,0.84,0.602,101,0.964,"naproxen, AM.404, sulfasalazine, metoxibutropate, suxibuzone",0.220403508742175,0.0159229660971692,FALSE +"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.48228,-1.13,0.308,1082,0.821,"morin, eplerenone, itraconazole",0.511449283499556,0.0856568428805592,FALSE +"HCC44","Pearson.est","DNA alkylating agent",-0.25409,-0.594,0.921,959,1,"estramustine, streptozotocin, dacarbazine, temozolomide, cyclophosphamide, carmustine",0.0357403698031511,0,FALSE +"HCC44","Pearson.est","DNA inhibitor",-0.22682,-0.528,0.971,849,1,"primaquine, busulfan, nimorazole, oxaliplatin, teroxirone, metronidazole, sangivamycin, carmustine",0.0127807700919951,0,FALSE +"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.57187,-1.33,0.146,1309,0.547,"azacitidine, decitabine",0.835647144215563,0.262012673666569,FALSE +"HCC44","Pearson.est","DNA polymerase inhibitor",-0.53296,-1.27,0.182,1032,0.535,"foscarnet, cidofovir, trifluridine, adefovir.dipivoxil, idoxuridine",0.739928612014925,0.271646217978772,FALSE +"HCC44","Pearson.est","DNA synthesis inhibitor",-0.27393,-0.641,0.89,1149,1,"capecitabine, cyclocytidine, CB.10.277, anisomycin",0.0506099933550872,0,FALSE +"HCC44","Pearson.est","dopamine receptor antagonist",-0.44209,-1.03,0.451,1063,0.911,"piperacetazine, UH.232...., domperidone, clebopride, oxiperomide, acetophenazine, mesoridazine",0.345823458122039,0.0404816230270017,FALSE +"HCC44","Pearson.est","estrogen receptor agonist",-0.24876,-0.587,0.936,948,1,"ethinyl.estradiol, estrone, PPT, erteberel",0.0287241512618947,0,FALSE +"HCC44","Pearson.est","estrogen receptor antagonist",0.33989,0.929,0.516,158,1,"toremifene, danazol",0.287350298372789,0,FALSE +"HCC44","Pearson.est","FGFR inhibitor",0.4823,1.34,0.148,284,0.788,"erdafitinib, nintedanib, lenvatinib, dovitinib, orantinib, regorafenib",0.829738284605043,0.103473782510445,FALSE +"HCC44","Pearson.est","FLT3 inhibitor",-0.21355,-0.498,0.98,893,0.997,"TG.02, GTP.14564, tandutinib, ENMD.2076, pacritinib, gilteritinib",0.00877392430750515,0.00130484168834428,FALSE +"HCC44","Pearson.est","glucocorticoid receptor agonist",-0.66066,-1.53,0.0501,1182,0.549,"difluprednate, prednisolone.acetate, halcinonide, rimexolone, dexamethasone.acetate, flumethasone.pivalate, flumethasone, methylprednisolone, desonide, halobetasol.propionate, triamcinolone.acetonide, ciclesonide, fluocinolone.acetonide, hydrocortisone",1.30016227413275,0.260427655549908,FALSE +"HCC44","Pearson.est","glutamate receptor antagonist",-0.27592,-0.636,0.873,1249,1,"diazooxonorleucine, SIB.1757",0.0589857562944303,0,FALSE +"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.26783,-0.62,0.909,1089,1,"TWS.119, kenpaullone, LY2090314",0.0414361167780325,0,FALSE +"HCC44","Pearson.est","growth factor receptor inhibitor",-0.57476,-1.35,0.139,1015,0.623,"danusertib, GSK1838705A, PHA.848125, AZD3463, GSK1904529A",0.856985199745905,0.20551195334083,FALSE +"HCC44","Pearson.est","HCV inhibitor",-0.36096,-0.851,0.67,1109,1,"embelin, PSI.7976",0.173925197299174,0,FALSE +"HCC44","Pearson.est","HDAC inhibitor",0.31392,0.886,0.553,224,0.977,"mocetinostat, pyroxamide, vorinostat, ACY.1215, scriptaid, chidamide, resminostat, M.344",0.257274868695302,0.0101054362812269,FALSE +"HCC44","Pearson.est","histamine receptor antagonist",-0.41138,-0.953,0.519,1020,0.886,"zolantidine, pheniramine, levocetirizine, ebastine, terfenadine, ranitidine, astemizole",0.284832642151542,0.0525662781129492,FALSE +"HCC44","Pearson.est","HMGCR inhibitor",0.75935,2.11,0.00858,60,0.132,"mevastatin, pitavastatin, atorvastatin",2.06651271215129,0.87942606879415,TRUE +"HCC44","Pearson.est","HSP inhibitor",-0.4145,-0.969,0.523,904,0.905,"tanespimycin, XL888, ganetespib, NVP.AUY922, SNX.2112, SNX.5422, PU.H71, BIIB021",0.281498311132726,0.0433514207947967,FALSE +"HCC44","Pearson.est","JAK inhibitor",-0.33483,-0.787,0.741,871,1,"baricitinib, atiprimod, TG.02, AZ960, CEP.33779, AZD1480, TG.101209, pacritinib, WHI.P154, filgotinib",0.130181792020672,0,FALSE +"HCC44","Pearson.est","KIT inhibitor",-0.25412,-0.601,0.92,1436,1,"dasatinib",0.0362121726544447,0,FALSE +"HCC44","Pearson.est","MDM inhibitor",0.26283,0.768,0.715,1069,1,"AMG.232, serdemetan, CGM097, idasanutlin, nutlin.3, RITA",0.145693958198919,0,FALSE +"HCC44","Pearson.est","MEK inhibitor",-0.77406,-1.8,0.00785,1295,0.295,"PD.184352, MEK162, refametinib, PD.318088, selumetinib, cobimetinib, Ro.4987655, AS.703026, PD.0325901, TAK.733, trametinib, AZD8330",2.10513034325475,0.530177984021837,FALSE +"HCC44","Pearson.est","MET inhibitor",-0.36281,-0.844,0.671,992,1,"PHA.665752, LY2801653, PF.04217903",0.173277479831008,0,FALSE +"HCC44","Pearson.est","microtubule inhibitor",-0.27379,-0.641,0.886,954,1,"D.64131, cabazitaxel, vinblastine, cytochalasin.b, podophyllotoxin",0.0525662781129492,0,FALSE +"HCC44","Pearson.est","mTOR inhibitor",-0.39847,-0.932,0.566,1069,0.906,"voxtalisib, torin.1, PF.04691502, LY303511, OSI.027, AZD8055, PP242, XL388, WAY.600, WYE.354, GSK2126458",0.247183568811729,0.0428718023231869,FALSE +"HCC44","Pearson.est","NFkB pathway inhibitor",-0.18799,-0.439,0.986,900,0.993,"EVP4593, bortezomib, curcumin, BAY.11.7085, betulinic.acid",0.0061230850587888,0.00305075150461883,FALSE +"HCC44","Pearson.est","opioid receptor agonist",-0.42135,-0.995,0.494,652,0.904,"spiradoline, ADL5859, salvinorin.a, cebranopadol, trimebutine",0.306273051076353,0.0438315695246367,FALSE +"HCC44","Pearson.est","p38 MAPK inhibitor",-0.55789,-1.29,0.174,809,0.547,"SB.242235, skepinone.l, VX.702, SB.239063, CMPD.1, TAK.715",0.7594507517174,0.262012673666569,FALSE +"HCC44","Pearson.est","PARP inhibitor",0.2542,0.687,0.85,342,0.953,"AZD2461, olaparib, talazoparib, PJ.34",0.0705810742857073,0.0209070993616736,FALSE +"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.33372,0.915,0.538,290,1,"nintedanib, lenvatinib, pazopanib, linifanib, motesanib, axitinib, dovitinib, trapidil, orantinib, sorafenib, regorafenib, telatinib",0.269217724333611,0,FALSE +"HCC44","Pearson.est","phosphatase inhibitor",0.35989,1,0.427,228,0.986,"bis.maltolato.oxovanadium.IV., BVT.948, menadione, CID.5458317",0.369572124974976,0.0061230850587888,FALSE +"HCC44","Pearson.est","phosphodiesterase inhibitor",0.2223,0.617,0.902,13,0.953,"enoximone",0.0447934624580583,0.0209070993616736,FALSE +"HCC44","Pearson.est","PI3K inhibitor",-0.47286,-1.11,0.324,941,0.84,"PIK.75, CH5132799, YM.201636, voxtalisib, PF.04691502, AZD6482, LY303511, buparlisib, taselisib, GDC.0941, alpelisib, TG.100713, GSK2126458",0.489454989793388,0.0757207139381184,FALSE +"HCC44","Pearson.est","PLK inhibitor",-0.45064,-1.05,0.377,772,0.892,"BI.2536, GSK461364, GW.843682X, rigosertib, NMS.1286937",0.423658649794207,0.0496351456238769,FALSE +"HCC44","Pearson.est","potassium channel blocker",0.25104,0.704,0.81,1086,0.97,"dofetilide, mepivacaine, meglitinide, ibutilide, ML133, oleoylethanolamide",0.0915149811213502,0.0132282657337552,FALSE +"HCC44","Pearson.est","PPAR receptor agonist",0.51969,1.48,0.0991,178,1,"GW.501516, clofibrate, pterostilbene",1.00392634551472,0,FALSE +"HCC44","Pearson.est","progesterone receptor agonist",0.49856,1.42,0.125,158,0.753,"norethindrone.acetate, norethindrone, norgestrel, danazol",0.903089986991944,0.123205023799299,FALSE +"HCC44","Pearson.est","proteasome inhibitor",0.41544,1.12,0.311,261,0.846,"delanzomib, ONX.0914, oprozomib, MG.132",0.507239610973163,0.0726296369609765,FALSE +"HCC44","Pearson.est","protein synthesis inhibitor",-0.33274,-0.78,0.747,786,1,"tedizolid.phosphate, florfenicol, chloramphenicol.palmitate, homoharringtonine, bruceantin, thiostrepton, emetine, cycloheximide, brefeldin.a",0.126679398184601,0,FALSE +"HCC44","Pearson.est","protein tyrosine kinase inhibitor",-0.56854,-1.34,0.148,1374,0.603,"NVP.TAE226, BMS.599626, AV.412",0.829738284605043,0.219682687859849,FALSE +"HCC44","Pearson.est","RAF inhibitor",-0.31407,-0.741,0.806,1014,1,"LGX818, CEP.32496, SB.590885, AZ.628",0.0936649581949093,0,FALSE +"HCC44","Pearson.est","RET tyrosine kinase inhibitor",-0.6037,-1.41,0.109,1418,0.787,"vandetanib",0.962573502059376,0.104025267640935,FALSE +"HCC44","Pearson.est","retinoid receptor agonist",0.43741,1.25,0.189,149,0.86,"fenretinide, adapalene, LE.135, bexarotene",0.723538195826756,0.0655015487564323,FALSE +"HCC44","Pearson.est","ribonucleotide reductase inhibitor",0.44038,1.21,0.22,250,0.831,"pentostatin, cladribine, hydroxyurea, fludarabine",0.657577319177794,0.080398976215889,FALSE +"HCC44","Pearson.est","serotonin receptor agonist",-0.42138,-0.993,0.484,1286,0.879,"ipsapirone",0.315154638355588,0.0560111249262281,FALSE +"HCC44","Pearson.est","serotonin receptor antagonist",-0.42529,-0.996,0.473,1072,0.932,"SB.216641, pirenperone, RS.16566, SB.228357",0.325138859262188,0.0305840876460186,FALSE +"HCC44","Pearson.est","sodium channel blocker",0.25567,0.716,0.803,25,1,"cibenzoline, oxcarbazepine",0.095284454721319,0,FALSE +"HCC44","Pearson.est","src inhibitor",-0.73033,-1.7,0.0117,1268,0.186,"PP.2, ZM.306416, bosutinib, saracatinib, dasatinib",1.93181413825384,0.730487055782084,TRUE +"HCC44","Pearson.est","sterol demethylase inhibitor",0.41401,1.18,0.242,259,0.796,"chlormidazole, ketoconazole, posaconazole",0.616184634019569,0.0990869322623309,FALSE +"HCC44","Pearson.est","TGF beta receptor inhibitor",-0.60439,-1.4,0.0913,1175,0.58,"D.4476, repsox",1.0395292224657,0.236572006437063,FALSE +"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.73496,-1.72,0.00789,1138,0.204,"trifluridine, capecitabine, ftorafur, raltitrexed, carmofur",2.10292299679058,0.690369832574101,TRUE +"HCC44","Pearson.est","topoisomerase inhibitor",-0.34027,-0.783,0.742,1124,1,"amsacrine, camptothecin, TAS.103, licochalcone.a, SN.38, idarubicin, exatecan.mesylate, fleroxacin",0.129596094720973,0,FALSE +"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.5069,-1.21,0.263,963,0.648,"vinblastine, dolastatin.10, vinorelbine, verubulin, plinabulin, paclitaxel, albendazole, oxibendazole, fosbretabulin, docetaxel, indibulin, podophyllotoxin, epothilone.b, parbendazole, nocodazole",0.580044251510242,0.188424994129407,FALSE +"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.55477,-1.29,0.175,1336,0.547,"aminopurvalanol.a, NVP.TAE226, tivantinib, BMS.599626, AV.412, vandetanib, dasatinib",0.756961951313706,0.262012673666569,FALSE +"HCC44","Pearson.est","VEGFR inhibitor",-0.30144,-0.71,0.83,1391,1,"BMS.690514, ZM.306416, vandetanib, XL.647",0.0809219076239261,0,FALSE +"HCC44","Pearson.est","vitamin D receptor agonist",-0.59072,-1.4,0.109,1126,0.58,"alfacalcidol, ercalcitriol, tacalcitol",0.962573502059376,0.236572006437063,FALSE +"A549","Pearson.est","EGFR inhibitor",-0.2672,-0.658,0.889,795,1,"ARRY.334543, tyrphostin.AG.494, CNX.2006, BMS.690514, dacomitinib, poziotinib, gefitinib, vandetanib, XL.647, afatinib, PD.153035, WZ8040, tyrphostin.AG.1478, pelitinib, PD.168393, erlotinib, OSI.420, icotinib, WZ.4002, BMS.599626",0.0510982390297863,0,FALSE +"A549","Pearson.est","Abl kinase inhibitor",-0.57696,-1.42,0.0984,1115,0.573,"KW.2449, flumatinib, GZD824, ponatinib, nilotinib, metatinib, bosutinib, dasatinib",1.00700490156866,0.24184537803261,FALSE +"A549","Pearson.est","acetylcholine receptor agonist",-0.24936,-0.616,0.911,672,1,"tremorine, nicotine, pilocarpine",0.0404816230270017,0,FALSE +"A549","Pearson.est","acetylcholine receptor antagonist",0.28502,0.834,0.658,1037,0.775,"diphemanil, iododexetimide, hyoscyamine, darifenacin, dicycloverine, methscopolamine",0.181774106386044,0.11069829749369,FALSE +"A549","Pearson.est","adenosine receptor antagonist",0.26509,0.825,0.677,1066,0.745,"MRS.1220, SCH.58261, istradefylline, CGS.15943, sulmazole, theophylline, PSB.1115",0.169411331314856,0.127843727251707,FALSE +"A549","Pearson.est","adrenergic receptor agonist",-0.31283,-0.759,0.774,1030,1,"oxymetazoline, isoetharine, midodrine, buphenine, clenbuterol, isoxsuprine",0.111259039317107,0,FALSE +"A549","Pearson.est","adrenergic receptor antagonist",-0.38915,-0.962,0.515,788,0.978,"prazosin, oxprenolol, RS.17053, carvedilol, pindolol, idazoxan, naftidrofuryl, dronedarone, imiloxan, vincamine, levobunolol, atipamezole",0.288192770958809,0.00966114521239857,FALSE +"A549","Pearson.est","AKT inhibitor",0.39772,1.21,0.214,110,0.471,"GDC.0068, uprosertib, GSK2110183, MK.2206",0.669586226650809,0.326979092871104,FALSE +"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.4207,-1.03,0.413,1444,0.95,"AZD3463",0.384049948343599,0.0222763947111523,FALSE +"A549","Pearson.est","androgen receptor antagonist",-0.77344,-1.89,0.0024,1389,0.147,"nilutamide, cyproterone.acetate, RU.58841",2.61978875828839,0.832682665251824,TRUE +"A549","Pearson.est","antioxidant",-0.59613,-1.47,0.0595,909,0.623,"taurine, chlorogenic.acid, mesna, trolox, rutin",1.22548303427145,0.20551195334083,FALSE +"A549","Pearson.est","AP inhibitor",0.53398,1.57,0.0391,678,0.187,"embelin, idronoxil, tanshinone.i, birinapant, GDC.0152, LCL.161",1.40782324260413,0.728158393463501,TRUE +"A549","Pearson.est","ATPase inhibitor",-0.5111,-1.26,0.201,1119,0.812,"digitoxin, digoxin, blebbistatin...., ouabain, digitoxigenin",0.696803942579511,0.0904439707588247,FALSE +"A549","Pearson.est","Aurora kinase inhibitor",-0.29338,-0.729,0.819,884,0.998,"MK.5108, hesperadin, SNS.314, alisertib, MLN.8054, KW.2449, CYC116, AT.9283, CCT129202, AMG900, PF.03814735",0.0867160982395816,0.000869458712628891,FALSE +"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.5828,-1.46,0.0896,1089,0.579,"tilmicosin, dirithromycin, valnemulin, radezolid, tedizolid",1.04769199033787,0.237321436272564,FALSE +"A549","Pearson.est","bacterial DNA gyrase inhibitor",-0.48335,-1.19,0.256,1433,0.849,"finafloxacin",0.59176003468815,0.0710923097560473,FALSE +"A549","Pearson.est","BCL inhibitor",0.27012,0.791,0.749,133,0.756,"ABT.737, oridonin, HA14.1",0.125518182300534,0.121478204498793,FALSE +"A549","Pearson.est","Bcr.Abl kinase inhibitor",-0.63302,-1.56,0.0375,1144,0.83,"flumatinib, GZD824, ponatinib, nilotinib, metatinib, bosutinib, dasatinib",1.42596873227228,0.0809219076239261,FALSE +"A549","Pearson.est","benzodiazepine receptor agonist",-0.3097,-0.761,0.781,1161,1,"lorazepam, CGS.20625, ivermectin, eprinomectin",0.1073489661227,0,FALSE +"A549","Pearson.est","bromodomain inhibitor",0.85058,2.55,0,190,0.00497,"I.BET151, OTX015, PFI.1, JQ1...., I.BET.762",Inf,2.30364361126667,TRUE +"A549","Pearson.est","calcium channel blocker",-0.20252,-0.499,0.988,1312,0.978,"cinnarazine",0.00524305541237188,0.00966114521239857,FALSE +"A549","Pearson.est","CC chemokine receptor antagonist",-0.39894,-0.992,0.494,1406,0.931,"navarixin",0.306273051076353,0.0310503190186574,FALSE +"A549","Pearson.est","CDK inhibitor",-0.54502,-1.35,0.122,1097,0.576,"CR8..R., NU6027, aminopurvalanol.a, JNJ.7706621, R547, abemaciclib, kenpaullone, PHA.848125, palbociclib, AZD5438, BMS.265246",0.913640169325252,0.239577516576788,FALSE +"A549","Pearson.est","CHK inhibitor",0.51839,1.55,0.0517,11,0.152,"PF.477736",1.28650945690606,0.818156412055227,FALSE +"A549","Pearson.est","cyclooxygenase inhibitor",-0.24007,-0.585,0.95,947,1,"piroxicam, meloxicam, acetylsalicylsalicylic.acid, tepoxalin, FR.122047, ketoprofen, indoprofen, tryptanthrin",0.0222763947111523,0,FALSE +"A549","Pearson.est","cytochrome P450 inhibitor",-0.58287,-1.44,0.078,934,0.574,"metyrapone, cobicistat, eplerenone, itraconazole",1.10790539730952,0.241088107602027,FALSE +"A549","Pearson.est","DNA alkylating agent",-0.44312,-1.1,0.352,764,0.964,"temozolomide, ifosfamide, dacarbazine, cyclophosphamide, melphalan, TH.302, carboplatin, carmustine, streptozotocin, mitomycin.c",0.453457336521869,0.0159229660971692,FALSE +"A549","Pearson.est","DNA inhibitor",-0.36606,-0.9,0.605,974,0.985,"melphalan, oxaliplatin, carboplatin, nimorazole, tirapazamine, valrubicin, carmustine, teroxirone",0.218244625347531,0.00656376950238827,FALSE +"A549","Pearson.est","DNA methyltransferase inhibitor",0.38071,1.16,0.245,23,0.498,"SGI.1027",0.610833915635468,0.302770657240282,FALSE +"A549","Pearson.est","DNA polymerase inhibitor",-0.30727,-0.757,0.774,1262,0.998,"idoxuridine, foscarnet",0.111259039317107,0.000869458712628891,FALSE +"A549","Pearson.est","DNA synthesis inhibitor",-0.54645,-1.35,0.149,1216,0.576,"CB.10.277, artesunate, floxuridine, mitomycin.c, cyclocytidine, anisomycin",0.826813731587726,0.239577516576788,FALSE +"A549","Pearson.est","dopamine receptor antagonist",-0.44472,-1.07,0.377,1145,0.938,"oxiperomide, amisulpride, piperacetazine, remoxipride, acetophenazine, mesoridazine, UH.232...., raclopride",0.423658649794207,0.0277971616209356,FALSE +"A549","Pearson.est","estrogen receptor agonist",-0.33536,-0.825,0.714,1156,1,"estradiol, estrone",0.146301788223826,0,FALSE +"A549","Pearson.est","estrogen receptor antagonist",0.68394,2.06,0.0166,1,0.072,"toremifene",1.77989191195995,1.14266750356873,TRUE +"A549","Pearson.est","FGFR inhibitor",-0.22677,-0.552,0.967,1381,0.972,"AZD4547",0.0145735259169983,0.0123337350737254,FALSE +"A549","Pearson.est","FLT3 inhibitor",-0.36625,-0.891,0.618,769,0.955,"pacritinib, ENMD.2076, gilteritinib, TG.101348, tandutinib, KW.2449, GTP.14564, ponatinib, midostaurin, quizartinib",0.209011524911184,0.0199966284162537,FALSE +"A549","Pearson.est","glucocorticoid receptor agonist",-0.55593,-1.37,0.134,1014,0.609,"methylprednisolone, dexamethasone.acetate, prednisolone, deflazacort, halcinonide, fludroxycortide, triamcinolone, flumethasone.pivalate, rimexolone, fluticasone.propionate, desonide, flumethasone, prednisolone.acetate, beclomethasone.dipropionate, ciclesonide, halobetasol.propionate, fluocinolone.acetonide",0.872895201635192,0.215382707367125,FALSE +"A549","Pearson.est","glutamate receptor antagonist",0.2729,0.834,0.649,161,0.775,"felbamate, CPP, CGP.37849",0.187755303199631,0.11069829749369,FALSE +"A549","Pearson.est","glycogen synthase kinase inhibitor",-0.3269,-0.809,0.725,1318,0.999,"TWS.119, kenpaullone",0.139661993429006,0.000434511774017692,FALSE +"A549","Pearson.est","growth factor receptor inhibitor",-0.63016,-1.54,0.0481,1371,0.708,"PHA.848125, AZD3463",1.31785492362617,0.149966742310231,FALSE +"A549","Pearson.est","HCV inhibitor",-0.36842,-0.904,0.603,855,1,"narlaprevir, Ro.9187, mericitabine",0.219682687859849,0,FALSE +"A549","Pearson.est","HDAC inhibitor",0.58289,1.79,0.024,248,0.119,"M.344, vorinostat, PCI.24781, tacedinaline, nexturastat.a, R306465, chidamide, NSC.3852, panobinostat, romidepsin, ACY.1215, trichostatin.a, pyroxamide, JNJ.26481585",1.61978875828839,0.924453038607469,TRUE +"A549","Pearson.est","histamine receptor antagonist",-0.252,-0.606,0.93,979,1,"zolantidine, cimetidine, tiotidine, BF2.649, pheniramine, terfenadine, nizatidine",0.0315170514460649,0,FALSE +"A549","Pearson.est","HMGCR inhibitor",0.33495,0.984,0.497,965,0.656,"pitavastatin, simvastatin, atorvastatin, mevastatin, lovastatin, fluvastatin",0.303643611266668,0.18309616062434,FALSE +"A549","Pearson.est","HSP inhibitor",-0.33644,-0.82,0.707,1049,1,"BIIB021, NVP.AUY922, PU.H71, ganetespib, SNX.2112, tanespimycin",0.150580586203101,0,FALSE +"A549","Pearson.est","JAK inhibitor",-0.44934,-1.09,0.35,1102,0.953,"CEP.33779, AT.9283, AZ960, WHI.P154, TG.101209, filgotinib",0.455931955649724,0.0209070993616736,FALSE +"A549","Pearson.est","KIT inhibitor",-0.30175,-0.732,0.823,1420,1,"KI.8751, dasatinib",0.0846001647877302,0,FALSE +"A549","Pearson.est","MDM inhibitor",-0.64964,-1.59,0.0238,1069,1,"serdemetan, nutlin.3, CGM097, idasanutlin, RITA",1.62342304294349,0,FALSE +"A549","Pearson.est","MEK inhibitor",-0.40769,-1,0.461,854,0.939,"U.0126, PD.184352, trametinib, Ro.4987655, PD.198306, selumetinib, TAK.733, PD.0325901, refametinib, AZD8330, PD.318088, arctigenin, nobiletin",0.336299074610352,0.0273344077338891,FALSE +"A549","Pearson.est","MET inhibitor",-0.3784,-0.926,0.574,804,1,"PHA.665752, NVP.BVU972, LY2801653, PF.04217903",0.241088107602027,0,FALSE +"A549","Pearson.est","microtubule inhibitor",-0.41579,-1.01,0.449,810,0.942,"vinblastine, cabazitaxel, secnidazole, D.64131, cytochalasin.b, podophyllotoxin",0.347753658996677,0.0259490972071227,FALSE +"A549","Pearson.est","mTOR inhibitor",-0.60826,-1.51,0.0639,958,0.681,"everolimus, OSI.027, deforolimus, PI.103, LY303511, PKI.179, palomid.529, voxtalisib, temsirolimus, WYE.125132, XL388, PP242, AZD2014, sirolimus, LY3023414, GSK2126458, NVP.BEZ235, GDC.0980, AZD8055, WAY.600, ku.0063794, MLN0128, SB.2343, WYE.354, torin.1",1.1944991418416,0.166852888087215,FALSE +"A549","Pearson.est","NFkB pathway inhibitor",0.25891,0.766,0.781,304,0.749,"parthenolide...., Ro.106.9920, parthenolide, bortezomib, bindarit, curcumin, tyloxapol",0.1073489661227,0.125518182300534,FALSE +"A549","Pearson.est","opioid receptor agonist",-0.49664,-1.2,0.251,830,0.864,"BW.180C, spiradoline, salvinorin.a, cebranopadol, trimebutine",0.600326278518962,0.0634862575211067,FALSE +"A549","Pearson.est","p38 MAPK inhibitor",-0.23173,-0.57,0.953,598,0.978,"CMPD.1, SB.242235, TAK.715, VX.702, skepinone.l",0.0209070993616736,0.00966114521239857,FALSE +"A549","Pearson.est","PARP inhibitor",-0.41165,-1.03,0.443,1437,0.95,"E7449",0.35359627377693,0.0222763947111523,FALSE +"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.37088,-0.91,0.597,1342,1,"CP.673451, KI.8751, crenolanib, dasatinib",0.224025668870631,0,FALSE +"A549","Pearson.est","phosphatase inhibitor",-0.25892,-0.637,0.898,1410,1,"mycophenolic.acid",0.0467236633326956,0,FALSE +"A549","Pearson.est","phosphodiesterase inhibitor",-0.33559,-0.817,0.715,1308,1,"zardaverine, YM.976",0.145693958198919,0,FALSE +"A549","Pearson.est","PI3K inhibitor",-0.46642,-1.14,0.297,993,0.925,"PI.103, LY303511, YM.201636, BGT226, PKI.179, voxtalisib, PI3K.IN.2, TG.100713, LY3023414, GDC.0941, GSK2126458, ZSTK.474, NVP.BEZ235, GDC.0980, SB.2343",0.527243550682788,0.0338582672609674,FALSE +"A549","Pearson.est","PLK inhibitor",-0.46077,-1.14,0.309,763,0.925,"HMN.214, BI.2536, GSK461364, volasertib, rigosertib, GW.843682X",0.510041520575165,0.0338582672609674,FALSE +"A549","Pearson.est","potassium channel blocker",-0.51452,-1.25,0.186,1203,0.795,"ibutilide, ML133",0.730487055782084,0.0996328713435297,FALSE +"A549","Pearson.est","PPAR receptor agonist",0.5059,1.57,0.0432,719,0.187,"pterostilbene, clofibrate, GW.501516, ciprofibrate, fenofibrate, S26948, oleoylethanolamide",1.36451625318509,0.728158393463501,TRUE +"A549","Pearson.est","progesterone receptor agonist",-0.41685,-1.02,0.445,1051,0.946,"dienogest, tanaproget, melengestrol.acetate",0.351639989019068,0.0241088635982073,FALSE +"A549","Pearson.est","proteasome inhibitor",0.51258,1.55,0.0783,231,0.152,"ONX.0914, carfilzomib, delanzomib, oprozomib, bortezomib",1.10623823794206,0.818156412055227,FALSE +"A549","Pearson.est","protein synthesis inhibitor",-0.49133,-1.2,0.219,1210,0.864,"emetine, brefeldin.a, methacycline, cycloheximide, mercaptopurine, florfenicol",0.659555885159882,0.0634862575211067,FALSE +"A549","Pearson.est","protein tyrosine kinase inhibitor",-0.3291,-0.813,0.708,1083,1,"NVP.TAE226, mubritinib, BMS.599626",0.149966742310231,0,FALSE +"A549","Pearson.est","RAF inhibitor",0.39358,1.15,0.268,154,0.468,"vemurafenib, TAK.632, regorafenib, AZ.628",0.571865205971211,0.329754146925876,FALSE +"A549","Pearson.est","RET tyrosine kinase inhibitor",0.35506,1.05,0.376,936,0.584,"regorafenib, sorafenib, sunitinib, cabozantinib, apatinib, vandetanib",0.424812155072339,0.233587152887601,FALSE +"A549","Pearson.est","retinoid receptor agonist",0.65541,1.94,0.024,318,0.0828,"fenretinide, adapalene, adarotene, tamibarotene, AM.580, CD.437",1.61978875828839,1.08196966321512,TRUE +"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.26455,-0.646,0.899,894,1,"cladribine, clofarabine, triapine, gemcitabine",0.0462403082667712,0,FALSE +"A549","Pearson.est","serotonin receptor agonist",-0.5982,-1.48,0.0652,1362,0.682,"aripiprazole, ipsapirone",1.18575240426808,0.166215625343521,FALSE +"A549","Pearson.est","serotonin receptor antagonist",-0.23574,-0.578,0.932,1296,0.989,"RS.16566, aripiprazole",0.0305840876460186,0.0048037084028206,FALSE +"A549","Pearson.est","sodium channel blocker",-0.36995,-0.905,0.586,1323,1,"A.803467, ajmaline, butamben",0.232102383981909,0,FALSE +"A549","Pearson.est","src inhibitor",-0.43544,-1.08,0.359,1397,0.945,"bosutinib, dasatinib",0.444905551421681,0.0245681914907371,FALSE +"A549","Pearson.est","sterol demethylase inhibitor",-0.36538,-0.892,0.601,670,0.977,"terconazole, sulconazole, lanoconazole, ketoconazole",0.22112552799726,0.0101054362812269,FALSE +"A549","Pearson.est","TGF beta receptor inhibitor",0.29126,0.868,0.58,1028,0.824,"LY2109761, D.4476, SB.525334, SB.431542, repsox, adaprev",0.236572006437063,0.0840727883028842,FALSE +"A549","Pearson.est","thymidylate synthase inhibitor",-0.5782,-1.41,0.0883,1253,0.548,"ftorafur, raltitrexed, carmofur",1.05403929642243,0.261219441515631,FALSE +"A549","Pearson.est","topoisomerase inhibitor",-0.44189,-1.11,0.347,1319,0.975,"exatecan.mesylate, teniposide, voreloxin, amsacrine, fleroxacin, idarubicin, TAS.103",0.459670525209126,0.0109953843014632,FALSE +"A549","Pearson.est","tubulin polymerization inhibitor",-0.42805,-1.05,0.396,810,0.961,"vinblastine, fenbendazole, dolastatin.10, plinabulin, albendazole, taltobulin, docetaxel, ABT.751, CYT.997, BNC105, parbendazole, epothilone.d, combretastatin.A.4, KX2.391, podophyllotoxin, verubulin, epothilone.b",0.402304814074488,0.0172766123314547,FALSE +"A549","Pearson.est","tyrosine kinase inhibitor",-0.26078,-0.626,0.902,833,1,"cabozantinib, hypericin, apatinib, vandetanib, UNC2250, NVP.TAE226, GTP.14564, aminopurvalanol.a, mubritinib, BMS.599626, dasatinib",0.0447934624580583,0,FALSE +"A549","Pearson.est","VEGFR inhibitor",-0.24381,-0.595,0.933,603,1,"tivozanib, sunitinib, SAR131675, semaxanib, SU014813, AEE788, motesanib, foretinib, PD.173074, TG.100572, ENMD.2076, RAF265, cabozantinib, nintedanib, BMS.690514, cediranib, vandetanib, ZM.306416, vatalanib, XL.647, telatinib, lucitanib, MGCD.265, KI.8751",0.0301183562535,0,FALSE +"A549","Pearson.est","vitamin D receptor agonist",-0.32022,-0.782,0.742,840,1,"alfacalcidol, ercalcitriol, tacalcitol",0.129596094720973,0,FALSE +"H1703","Pearson.est","EGFR inhibitor",0.82362,2.03,0,57,0.0668,"poziotinib, AZD8931, gefitinib, dacomitinib, XL.647, neratinib, afatinib, canertinib, lapatinib, erlotinib, osimertinib, BIBU.1361, AST.1306, pelitinib, BMS.690514, PD.153035, vandetanib, CUDC.101, tucatinib, icotinib, BMS.599626, ARRY.334543, PD.168393, WZ8040",Inf,1.17522353752445,TRUE +"H1703","Pearson.est","Abl kinase inhibitor",0.46962,1.2,0.265,104,0.877,"dasatinib, ZM.306416, bosutinib",0.576754126063192,0.0570004066339595,FALSE +"H1703","Pearson.est","acetylcholine receptor agonist",-0.28411,-0.709,0.807,1007,0.904,"nefiracetam, xanomeline, oxiracetam",0.0931264652779296,0.0438315695246367,FALSE +"H1703","Pearson.est","acetylcholine receptor antagonist",-0.56334,-1.38,0.126,1032,0.534,"diphemanil, darifenacin, iododexetimide, methscopolamine",0.899629454882437,0.272458742971444,FALSE +"H1703","Pearson.est","adenosine receptor antagonist",0.68445,1.73,0.0294,170,0.216,"CGS.15943, MRS.1220, SCH.58261, PSB.1115",1.53165266958784,0.665546248849069,TRUE +"H1703","Pearson.est","adrenergic receptor agonist",0.26044,0.654,0.893,150,0.977,"ritodrine, oxymetazoline, isoxsuprine",0.0491485411114536,0.0101054362812269,FALSE +"H1703","Pearson.est","adrenergic receptor antagonist",-0.30126,-0.735,0.782,1286,0.912,"metoprolol, carvedilol, pindolol",0.106793246940152,0.0400051616715838,FALSE +"H1703","Pearson.est","AKT inhibitor",0.4272,1.06,0.381,414,0.769,"uprosertib, triciribine, AZD5363, GDC.0068, CCT128930, MK.2206, GSK2110183, palomid.529",0.419075024324381,0.114073660198569,FALSE +"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.20058,0.526,0.968,523,1,"GW.788388, SB.505124, brigatinib, alectinib, AZD3463, CEP.37440, AP26113, NVP.TAE684",0.0141246426916063,0,FALSE +"H1703","Pearson.est","androgen receptor antagonist",-0.47712,-1.16,0.296,688,0.661,"cyproterone.acetate, bicalutamide, enzalutamide, RU.58841, nilutamide, flutamide",0.528708288941061,0.17979854051436,FALSE +"H1703","Pearson.est","antioxidant",0.4485,1.12,0.306,44,0.921,"mesna",0.51427857351842,0.0357403698031511,FALSE +"H1703","Pearson.est","AP inhibitor",-0.40077,-0.989,0.48,1417,0.77,"idronoxil",0.318758762624413,0.113509274827518,FALSE +"H1703","Pearson.est","ATPase inhibitor",-0.61923,-1.51,0.0802,984,0.498,"evodiamine, blebbistatin...., ouabain, omeprazole, k.strophanthidin, thonzonium, digitoxin, digitoxigenin, digoxin, oligomycin.a",1.09582563171584,0.302770657240282,FALSE +"H1703","Pearson.est","Aurora kinase inhibitor",-0.63111,-1.57,0.0538,988,0.41,"hesperadin, TAK.901, alisertib, KW.2449, MK.5108, CCT137690, MK.8745, tozasertib, danusertib, barasertib.HQPA, AT.9283, aurora.a.inhibitor.i, ZM.447439, SNS.314, PF.03814735, AMG900, barasertib",1.26921772433361,0.387216143280265,FALSE +"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.21224,0.54,0.954,432,1,"tedizolid, azithromycin, azalomycin.b, tilmicosin",0.0204516252959049,0,FALSE +"H1703","Pearson.est","bacterial DNA gyrase inhibitor",0.31223,0.796,0.693,46,0.932,"finafloxacin",0.159266765388193,0.0305840876460186,FALSE +"H1703","Pearson.est","BCL inhibitor",-0.32548,-0.794,0.711,776,0.916,"venetoclax, navitoclax, ABT.737, HA14.1, TW.37, oridonin",0.148130399270234,0.0381045263321496,FALSE +"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.40935,1.03,0.421,104,0.744,"dasatinib, bosutinib",0.375717904164332,0.128427064454121,FALSE +"H1703","Pearson.est","benzodiazepine receptor agonist",0.17979,0.456,0.991,1190,0.99,"piperazine, CL.218872, lorazepam, zaleplon, ivermectin, eprinomectin, gamma.aminobutyric.acid, ZK.93423, CGS.20625, temazepam, bentazepam, nefiracetam, indiplon",0.00392634551472468,0.00436480540245009,FALSE +"H1703","Pearson.est","bromodomain inhibitor",0.39459,0.993,0.423,879,0.705,"JQ1...., OTX015, I.BET.762, I.BET151, bromosporine, PFI.1",0.373659632624958,0.151810883008601,FALSE +"H1703","Pearson.est","calcium channel blocker",-0.32585,-0.795,0.738,1060,0.939,"penfluridol, pranidipine, SR.33805, carboxyamidotriazole",0.131943638176958,0.0273344077338891,FALSE +"H1703","Pearson.est","CC chemokine receptor antagonist",-0.3392,-0.827,0.648,1261,0.911,"MK.0812, UNBS.5162",0.188424994129407,0.0404816230270017,FALSE +"H1703","Pearson.est","CDK inhibitor",0.19668,0.494,0.975,237,1,"indirubin, alvocidib, P276.00, TG.02, AZD5438",0.0109953843014632,0,FALSE +"H1703","Pearson.est","CHK inhibitor",-0.34312,-0.832,0.652,1110,0.929,"SB.218078, PF.477736",0.18575240426808,0.0319842860063582,FALSE +"H1703","Pearson.est","cyclooxygenase inhibitor",-0.39138,-0.977,0.459,1370,0.765,"tepoxalin, suxibuzone, AM.404, naproxen",0.338187314462739,0.116338564846382,FALSE +"H1703","Pearson.est","cytochrome P450 inhibitor",-0.35725,-0.876,0.594,1104,0.9,"clotrimazole, metyrapone, cobicistat",0.226213555018806,0.0457574905606751,FALSE +"H1703","Pearson.est","DNA alkylating agent",-0.49277,-1.19,0.25,1080,0.666,"TH.302, mitomycin.c, carboplatin, satraplatin, cisplatin, dianhydrogalactitol, melphalan",0.602059991327962,0.176525770829699,FALSE +"H1703","Pearson.est","DNA inhibitor",-0.4796,-1.14,0.32,1122,0.671,"tirapazamine, pibenzimol, carboplatin, valrubicin, melphalan, chlorambucil",0.494850021680094,0.173277479831008,FALSE +"H1703","Pearson.est","DNA methyltransferase inhibitor",0.46029,1.17,0.309,210,0.872,"azacitidine, decitabine, fdcyd",0.510041520575165,0.0594835150674328,FALSE +"H1703","Pearson.est","DNA polymerase inhibitor",-0.28929,-0.712,0.794,1123,0.921,"menadione, cephalomannine",0.100179497572904,0.0357403698031511,FALSE +"H1703","Pearson.est","DNA synthesis inhibitor",-0.53567,-1.33,0.158,1157,0.518,"enocitabine, mitomycin.c, estramustine.phosphate, azodicarbonamide, cisplatin, artemisinin",0.801342913045577,0.285670240254767,FALSE +"H1703","Pearson.est","dopamine receptor antagonist",0.42894,1.08,0.385,221,0.822,"domperidone, clebopride, lurasidone, acetophenazine, mesoridazine, oxiperomide",0.414539270491499,0.0851281824599496,FALSE +"H1703","Pearson.est","estrogen receptor agonist",0.35167,0.923,0.518,198,0.768,"erteberel, levonorgestrel, ethinyl.estradiol",0.285670240254767,0.114638779968488,FALSE +"H1703","Pearson.est","estrogen receptor antagonist",0.43335,1.1,0.331,111,0.833,"clomifene, raloxifene",0.480172006224281,0.0793549985932124,FALSE +"H1703","Pearson.est","FGFR inhibitor",-0.58078,-1.4,0.121,1216,0.536,"regorafenib, lenvatinib, dovitinib, nintedanib, erdafitinib",0.91721462968355,0.27083521030723,FALSE +"H1703","Pearson.est","FLT3 inhibitor",-0.41291,-0.997,0.472,1036,0.812,"KW.2449, tyrphostin.AG.1296, tozasertib, quizartinib, sorafenib, TG.101348, midostaurin, dovitinib",0.326058001365912,0.0904439707588247,FALSE +"H1703","Pearson.est","glucocorticoid receptor agonist",0.55382,1.41,0.0874,295,0.618,"hydrocortisone, triamcinolone.acetonide, ciclesonide, fluocinolone.acetonide, flumethasone.pivalate, desonide, difluprednate, methylprednisolone, dexamethasone.acetate, fludroxycortide, prednisolone, flumethasone, halobetasol.propionate",1.0584885673656,0.209011524911184,FALSE +"H1703","Pearson.est","glutamate receptor antagonist",0.39271,1.01,0.427,340,0.708,"diazooxonorleucine, SIB.1757, CGP.37849, IEM1754, kynurenic.acid, latrepirdine, CPP",0.369572124974976,0.149966742310231,FALSE +"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.33722,0.85,0.618,152,0.869,"indirubin, LY2090314",0.209011524911184,0.0609802235513335,FALSE +"H1703","Pearson.est","growth factor receptor inhibitor",0.30297,0.771,0.676,71,0.942,"GSK1904529A",0.170053304058364,0.0259490972071227,FALSE +"H1703","Pearson.est","HCV inhibitor",-0.35152,-0.864,0.612,1038,0.896,"Ro.9187, mericitabine, narlaprevir",0.213248577854439,0.0476919903378748,FALSE +"H1703","Pearson.est","HDAC inhibitor",-0.19195,-0.471,0.99,677,0.986,"trichostatin.a, AR.42, vorinostat, M.344, R306465, nexturastat.a, RGFP966, mocetinostat, dacinostat, NSC.3852, ACY.1215, SB.939, belinostat, pyroxamide, RG2833, entinostat, resminostat, scriptaid, chidamide",0.00436480540245009,0.0061230850587888,FALSE +"H1703","Pearson.est","histamine receptor antagonist",0.29217,0.733,0.753,181,0.936,"ranitidine, terfenadine, levocetirizine, astemizole",0.123205023799299,0.0287241512618947,FALSE +"H1703","Pearson.est","HMGCR inhibitor",-0.94383,-2.26,0,1408,0,"fluvastatin, mevastatin, atorvastatin, pitavastatin",Inf,Inf,TRUE +"H1703","Pearson.est","HSP inhibitor",-0.52095,-1.28,0.211,1069,0.584,"PU.H71, SNX.2112, NVP.AUY922, ganetespib, NMS.E973",0.675717544702307,0.233587152887601,FALSE +"H1703","Pearson.est","JAK inhibitor",-0.27921,-0.678,0.842,1154,0.921,"tozasertib, ruxolitinib, AT.9283, TG.101348, PRT062070",0.0746879085003505,0.0357403698031511,FALSE +"H1703","Pearson.est","KIT inhibitor",-0.50547,-1.24,0.232,1180,0.598,"telatinib, cediranib, regorafenib, sorafenib, midostaurin, motesanib, lenvatinib, pazopanib",0.6345120151091,0.223298816011589,FALSE +"H1703","Pearson.est","MDM inhibitor",-0.37108,-0.901,0.586,1121,0.882,"AMG.232, serdemetan",0.232102383981909,0.0545314148681803,FALSE +"H1703","Pearson.est","MEK inhibitor",0.84685,2.18,0,107,0.0169,"trametinib, AS.703026, cobimetinib, AZD8330, TAK.733, PD.0325901, selumetinib, Ro.4987655, MEK162, PD.318088, refametinib, PD.198306, PD.184352",Inf,1.77211329538633,TRUE +"H1703","Pearson.est","MET inhibitor",-0.40727,-1,0.442,1126,0.836,"LY2801653, AMG458",0.354577730650908,0.0777937225609836,FALSE +"H1703","Pearson.est","microtubule inhibitor",-0.61266,-1.49,0.0643,881,0.429,"triclabendazole, colchicine, D.64131, cytochalasin.b, podophyllotoxin, estramustine.phosphate, cabazitaxel, secnidazole, vinflunine, vinblastine",1.19178902707578,0.367542707815276,FALSE +"H1703","Pearson.est","mTOR inhibitor",0.26649,0.663,0.832,378,0.999,"GSK2126458, LY303511, PP242, WAY.600, XL388, WYE.354, OSI.027, PF.04691502, GDC.0980, voxtalisib, WYE.125132",0.0798766737092761,0.000434511774017692,FALSE +"H1703","Pearson.est","NFkB pathway inhibitor",-0.19837,-0.48,0.981,1325,1,"BAY.11.7082",0.0083309926200515,0,FALSE +"H1703","Pearson.est","opioid receptor agonist",-0.22538,-0.54,0.957,325,1,"ADL5859, trimebutine, BW.180C, cebranopadol, salvinorin.a, spiradoline",0.0190880622231565,0,FALSE +"H1703","Pearson.est","p38 MAPK inhibitor",0.54823,1.39,0.135,658,0.584,"SB.239063, TAK.715, talmapimod, SB.242235, skepinone.l, CMPD.1, VX.702",0.869666231504994,0.233587152887601,FALSE +"H1703","Pearson.est","PARP inhibitor",-0.59277,-1.45,0.0952,1307,0.471,"olaparib, AZD2461, talazoparib",1.02136305161553,0.326979092871104,FALSE +"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.55008,-1.35,0.161,1171,0.515,"crenolanib, telatinib, trapidil, regorafenib, CP.673451, linifanib, sorafenib, motesanib, lenvatinib, dovitinib, axitinib, nintedanib, pazopanib",0.79317412396815,0.288192770958809,FALSE +"H1703","Pearson.est","phosphatase inhibitor",-0.42808,-1.05,0.407,1062,0.765,"AS.1949490, menadione, BVT.948, GSK2830371, bis.maltolato.oxovanadium.IV.",0.39040559077478,0.116338564846382,FALSE +"H1703","Pearson.est","phosphodiesterase inhibitor",-0.40968,-0.996,0.476,1176,0.785,"zardaverine, YM.976, enoximone, GSK256066",0.322393047279507,0.105130343254747,FALSE +"H1703","Pearson.est","PI3K inhibitor",0.4203,1.05,0.398,351,0.746,"alpelisib, taselisib, GSK2126458, TG.100713, CH5132799, LY303511, GDC.0941, PIK.75, PF.04691502, PI.828, GDC.0980, AZD6482, voxtalisib",0.400116927926312,0.127261172527331,FALSE +"H1703","Pearson.est","PLK inhibitor",-0.64391,-1.59,0.0495,1127,0.726,"GSK461364, HMN.214, BI.2536, rigosertib, volasertib",1.30539480106643,0.139063379299906,FALSE +"H1703","Pearson.est","potassium channel blocker",-0.5592,-1.36,0.151,1416,0.534,"dofetilide",0.821023052706831,0.272458742971444,FALSE +"H1703","Pearson.est","PPAR receptor agonist",-0.44832,-1.12,0.342,1054,0.655,"pterostilbene, clofibrate, GW.501516",0.465973893943865,0.183758700008217,FALSE +"H1703","Pearson.est","progesterone receptor agonist",-0.31414,-0.767,0.75,982,0.911,"danazol, dienogest, tanaproget, norgestrel, norethindrone",0.1249387366083,0.0404816230270017,FALSE +"H1703","Pearson.est","proteasome inhibitor",-0.45691,-1.12,0.324,926,0.655,"ixazomib, oprozomib, delanzomib, ONX.0914, MG.132",0.489454989793388,0.183758700008217,FALSE +"H1703","Pearson.est","protein synthesis inhibitor",-0.51746,-1.27,0.21,1161,0.569,"thiostrepton, clofoctol, puromycin, bruceantin, mercaptopurine, homoharringtonine, harringtonine, anguidine",0.677780705266081,0.244887733604929,FALSE +"H1703","Pearson.est","protein tyrosine kinase inhibitor",0.54835,1.43,0.105,200,0.664,"BMS.599626, AV.412, NVP.TAE226, CP.724714",0.978810700930062,0.177831920631982,FALSE +"H1703","Pearson.est","RAF inhibitor",0.30081,0.767,0.733,156,0.914,"AZ.628, CEP.32496, SB.590885",0.134896025358872,0.0390538042661686,FALSE +"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.44018,1.11,0.323,29,0.873,"vandetanib",0.490797477668897,0.0589857562944303,FALSE +"H1703","Pearson.est","retinoid receptor agonist",0.40017,1.01,0.441,48,0.708,"CD.437, tamibarotene",0.355561410532161,0.149966742310231,FALSE +"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.63686,-1.57,0.0595,963,0.41,"hydroxyurea, fludarabine.phosphate, triapine, gemcitabine, fludarabine, cladribine, clofarabine, pentostatin",1.22548303427145,0.387216143280265,FALSE +"H1703","Pearson.est","serotonin receptor agonist",-0.62589,-1.57,0.0587,1151,0.41,"SR.57227A, pardoprunox, aripiprazole",1.23136189875239,0.387216143280265,FALSE +"H1703","Pearson.est","serotonin receptor antagonist",-0.47896,-1.17,0.268,1262,0.674,"paliperidone, lerisetron, aripiprazole",0.571865205971211,0.17134010346468,FALSE +"H1703","Pearson.est","sodium channel blocker",-0.25562,-0.619,0.909,1021,0.963,"brivaracetam, triamterene, oxcarbazepine, butamben, cibenzoline",0.0414361167780325,0.0163737128754655,FALSE +"H1703","Pearson.est","src inhibitor",0.66148,1.76,0.0208,104,0.224,"saracatinib, dasatinib, ZM.306416, bosutinib",1.68193666503724,0.649751981665837,TRUE +"H1703","Pearson.est","sterol demethylase inhibitor",-0.31245,-0.772,0.73,1392,0.927,"chlormidazole",0.136677139879544,0.0329202658555029,FALSE +"H1703","Pearson.est","TGF beta receptor inhibitor",0.38532,0.99,0.458,480,0.679,"repsox, D.4476, SB.431542, LY2109761",0.339134521996131,0.168130225719498,FALSE +"H1703","Pearson.est","thymidylate synthase inhibitor",0.46965,1.2,0.249,364,0.877,"carmofur, capecitabine, raltitrexed",0.603800652904264,0.0570004066339595,FALSE +"H1703","Pearson.est","topoisomerase inhibitor",-0.73872,-1.81,0.0152,1243,0.23,"irinotecan, dexrazoxane, rubitecan, voreloxin, doxorubicin, valrubicin, mitoxantrone, TAS.103, amonafide, nemorubicin, daunorubicin, teniposide, etoposide, topotecan, etoposide.phosphate, epirubicin",1.81815641205523,0.638272163982407,TRUE +"H1703","Pearson.est","tubulin polymerization inhibitor",-0.60989,-1.5,0.0875,973,0.458,"fosbretabulin, epothilone.b, podophyllotoxin, mebendazole, fenbendazole, flubendazole, plinabulin, vinorelbine, docetaxel, epothilone.d, ABT.751, dolastatin.10, paclitaxel, CYT.997, vincristine, combretastatin.A.4, vindesine, KX2.391, vinblastine, verubulin, taltobulin, BNC105",1.05799194697769,0.339134521996131,FALSE +"H1703","Pearson.est","tyrosine kinase inhibitor",0.41593,1.06,0.374,200,0.769,"vandetanib, dasatinib, BMS.599626, AV.412, NVP.TAE226, hypericin, GTP.14564, CP.724714",0.42712839779952,0.114073660198569,FALSE +"H1703","Pearson.est","VEGFR inhibitor",-0.30703,-0.751,0.753,1180,0.912,"telatinib, cediranib, regorafenib, SAR131675, RAF265, linifanib, sorafenib, motesanib, lenvatinib, dovitinib, axitinib, tivozanib, nintedanib, pazopanib",0.123205023799299,0.0400051616715838,FALSE +"H1703","Pearson.est","vitamin D receptor agonist",0.70695,1.79,0.0187,321,0.254,"tacalcitol, paricalcitol, calcitriol, maxacalcitol, ercalcitriol, alfacalcidol",1.7281583934635,0.595166283380062,FALSE +"HCC15","Pearson.est","EGFR inhibitor",0.7297,1.75,0.00865,80,0.649,"gefitinib, poziotinib, afatinib, pelitinib, XL.647, CUDC.101, AZD8931, erlotinib, dacomitinib, BIBU.1361, AST.1306, osimertinib, lapatinib, neratinib, vandetanib, canertinib, icotinib, PD.153035, WZ.4002, tucatinib",2.06298389253519,0.187755303199631,FALSE +"HCC15","Pearson.est","Abl kinase inhibitor",0.56625,1.35,0.148,484,0.67,"dasatinib, ZM.306416, tozasertib, GZD824, nilotinib, ponatinib, imatinib, bosutinib",0.829738284605043,0.173925197299174,FALSE +"HCC15","Pearson.est","acetylcholine receptor agonist",-0.3505,-0.923,0.483,1398,0.728,"nefiracetam",0.316052869248488,0.137868620686963,FALSE +"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.27741,-0.739,0.748,1143,0.878,"darifenacin, diphemanil, methscopolamine",0.126098402135539,0.0565054840938974,FALSE +"HCC15","Pearson.est","adenosine receptor antagonist",0.48282,1.19,0.243,301,0.717,"istradefylline, sulmazole, CGS.15943, PSB.1115",0.614393726401688,0.1444808443322,FALSE +"HCC15","Pearson.est","adrenergic receptor agonist",0.30493,0.732,0.778,334,0.955,"ritodrine, terbutaline, oxymetazoline, methyldopa, isoxsuprine",0.109020403010311,0.0199966284162537,FALSE +"HCC15","Pearson.est","adrenergic receptor antagonist",-0.3474,-0.935,0.538,1306,0.74,"levobunolol, metoprolol, propranolol, pindolol",0.269217724333611,0.130768280269024,FALSE +"HCC15","Pearson.est","AKT inhibitor",0.38654,0.927,0.548,384,0.793,"uprosertib, MK.2206, GSK2110183, triciribine, AT7867",0.261219441515631,0.100726812682396,FALSE +"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.49057,1.17,0.273,400,0.697,"lorlatinib, SB.505124, CEP.37440, alectinib, AZD3463",0.563837352959244,0.156767221901991,FALSE +"HCC15","Pearson.est","androgen receptor antagonist",-0.82341,-2.22,0.00342,1256,0.0411,"flutamide, RU.58841, enzalutamide, cyproterone.acetate",2.46597389394387,1.38615817812393,TRUE +"HCC15","Pearson.est","antioxidant",-0.45702,-1.2,0.266,1426,0.628,"taurine, rutin",0.575118363368933,0.202040356262804,FALSE +"HCC15","Pearson.est","AP inhibitor",-0.43189,-1.16,0.257,1212,0.653,"birinapant, LCL.161, GDC.0152",0.590066876668705,0.185086818724926,FALSE +"HCC15","Pearson.est","ATPase inhibitor",-0.48383,-1.3,0.193,1266,0.707,"omeprazole, digitoxin, rabeprazole, digitoxigenin, oligomycin.a",0.714442690992226,0.150580586203101,FALSE +"HCC15","Pearson.est","Aurora kinase inhibitor",0.12973,0.308,0.999,320,1,"GSK1070916, tozasertib, ENMD.2076",0.000434511774017692,0,FALSE +"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.26389,-0.709,0.792,380,0.858,"tedizolid, valnemulin, azithromycin, tilmicosin, azalomycin.b, dirithromycin, radezolid, josamycin",0.101274818410506,0.0665127121512946,FALSE +"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.21394,0.514,0.978,380,0.989,"finafloxacin, novobiocin, sarafloxacin",0.00966114521239857,0.0048037084028206,FALSE +"HCC15","Pearson.est","BCL inhibitor",0.34132,0.809,0.67,346,0.886,"obatoclax, gossypol, venetoclax",0.173925197299174,0.0525662781129492,FALSE +"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",0.57356,1.38,0.122,484,0.921,"dasatinib, tozasertib, GZD824, nilotinib, ponatinib, imatinib, bosutinib",0.913640169325252,0.0357403698031511,FALSE +"HCC15","Pearson.est","benzodiazepine receptor agonist",0.26517,0.64,0.891,543,0.961,"ZK.93423, piperazine, bentazepam, zaleplon, CL.218872, eprinomectin",0.0501222959631252,0.0172766123314547,FALSE +"HCC15","Pearson.est","bromodomain inhibitor",0.46165,1.14,0.31,491,0.701,"JQ1...., I.BET.762, OTX015, I.BET151",0.508638306165727,0.154281982033341,FALSE +"HCC15","Pearson.est","calcium channel blocker",0.41373,0.993,0.461,560,0.737,"tetrandrine, SKF.96365, efonidipine.monoethanolate, penfluridol, mibefradil, fendiline",0.336299074610352,0.132532512140949,FALSE +"HCC15","Pearson.est","CC chemokine receptor antagonist",0.55356,1.35,0.155,173,0.67,"ZK811752, PF.04136309",0.809668301829709,0.173925197299174,FALSE +"HCC15","Pearson.est","CDK inhibitor",0.49761,1.18,0.295,385,0.706,"indisulam, P276.00, alvocidib, AT.7519, TG.02, dinaciclib, AZD5438, ribociclib, PHA.848125, palbociclib, JNJ.7706621",0.530177984021837,0.151195298948196,FALSE +"HCC15","Pearson.est","CHK inhibitor",-0.32408,-0.875,0.615,467,0.747,"LY2603618, AZD7762, LY2606368, PF.477736, SCH.900776, CHIR.124, SB.218078",0.211124884224583,0.126679398184601,FALSE +"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.4483,-1.24,0.2,1347,0.611,"AM.404, sulfasalazine, metoxibutropate, suxibuzone, naproxen",0.698970004336019,0.213958789757446,FALSE +"HCC15","Pearson.est","cytochrome P450 inhibitor",0.49946,1.2,0.252,165,0.731,"morin, metyrapone",0.598599459218456,0.13608262304214,FALSE +"HCC15","Pearson.est","DNA alkylating agent",-0.38211,-1.04,0.329,1151,0.623,"streptozotocin, ifosfamide, melphalan, satraplatin, cisplatin, dianhydrogalactitol, mitomycin.c",0.482804102050026,0.20551195334083,FALSE +"HCC15","Pearson.est","DNA inhibitor",0.22993,0.549,0.945,229,0.992,"sangivamycin, carmustine, bendamustine",0.0245681914907371,0.00348832784582135,FALSE +"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.39417,0.945,0.502,225,0.782,"decitabine, azacitidine",0.299296282854981,0.106793246940152,FALSE +"HCC15","Pearson.est","DNA polymerase inhibitor",0.40542,0.994,0.467,193,0.758,"cidofovir, idoxuridine",0.330683119433888,0.120330794367946,FALSE +"HCC15","Pearson.est","DNA synthesis inhibitor",-0.60115,-1.68,0.0639,1322,0.286,"floxuridine, cisplatin, artemisinin, estramustine.phosphate, mitomycin.c",1.1944991418416,0.543633966870957,FALSE +"HCC15","Pearson.est","dopamine receptor antagonist",0.45684,1.08,0.391,250,0.687,"clebopride, lurasidone, domperidone, mesoridazine, sertindole, amisulpride, thioproperazine",0.407823242604133,0.16304326294045,FALSE +"HCC15","Pearson.est","estrogen receptor agonist",-0.29437,-0.81,0.645,1442,0.828,"estradiol.cypionate",0.190440285364732,0.0819696632151199,FALSE +"HCC15","Pearson.est","estrogen receptor antagonist",0.63709,1.55,0.0579,134,0.529,"raloxifene, clomifene",1.23732143627256,0.276544327964814,FALSE +"HCC15","Pearson.est","FGFR inhibitor",0.40749,0.998,0.457,318,0.774,"PD.173074, MK.2461, lucitanib, regorafenib",0.34008379993015,0.111259039317107,FALSE +"HCC15","Pearson.est","FLT3 inhibitor",0.4217,1.03,0.417,430,0.736,"gilteritinib, pacritinib, tozasertib, TG.02, sunitinib, ENMD.2076, sorafenib, ponatinib, tyrphostin.AG.1296",0.379863945026242,0.133122185662501,FALSE +"HCC15","Pearson.est","glucocorticoid receptor agonist",0.52471,1.25,0.208,327,0.687,"hydrocortisone, ciclesonide, triamcinolone.acetonide, difluprednate, flumethasone.pivalate, halcinonide, halobetasol.propionate, fluocinolone.acetonide, prednisolone.acetate, desonide, prednisolone",0.681936665037238,0.16304326294045,FALSE +"HCC15","Pearson.est","glutamate receptor antagonist",0.28399,0.693,0.832,354,0.965,"SIB.1757, CPP, diazooxonorleucine, CGP.37849",0.0798766737092761,0.0154726866562074,FALSE +"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.18838,-0.512,0.971,1218,0.978,"indirubin, CHIR.98014",0.0127807700919951,0.00966114521239857,FALSE +"HCC15","Pearson.est","growth factor receptor inhibitor",0.46534,1.13,0.317,501,0.664,"GSK1904529A, GSK1838705A, PHA.848125, AZD3463, lestaurtinib, danusertib",0.498940737782249,0.177831920631982,FALSE +"HCC15","Pearson.est","HCV inhibitor",0.34683,0.83,0.679,47,0.897,"embelin",0.168130225719498,0.0472075569559079,FALSE +"HCC15","Pearson.est","HDAC inhibitor",0.51246,1.26,0.221,360,0.706,"PCI.24781, R306465, M.344, romidepsin, JNJ.26481585, dacinostat, givinostat, belinostat, trichostatin.a, NSC.3852, vorinostat, panobinostat, tacedinaline, entinostat, nexturastat.a",0.655607726314889,0.151195298948196,FALSE +"HCC15","Pearson.est","histamine receptor antagonist",0.34689,0.828,0.671,479,0.877,"ranitidine, astemizole, pheniramine, ebastine, chloropyramine, tecastemizole, lafutidine",0.173277479831008,0.0570004066339595,FALSE +"HCC15","Pearson.est","HMGCR inhibitor",0.48141,1.16,0.295,470,0.688,"lovastatin, pitavastatin, simvastatin",0.530177984021837,0.162411561764489,FALSE +"HCC15","Pearson.est","HSP inhibitor",-0.4397,-1.14,0.286,1253,0.642,"XL888, KW.2478, alvespimycin, VER.49009, tanespimycin",0.543633966870957,0.192464971931147,FALSE +"HCC15","Pearson.est","JAK inhibitor",0.37889,0.91,0.574,389,0.803,"atiprimod, pacritinib, tozasertib, TG.02, filgotinib, AZD1480",0.241088107602027,0.095284454721319,FALSE +"HCC15","Pearson.est","KIT inhibitor",0.27329,0.658,0.885,483,0.962,"dasatinib, sunitinib, regorafenib, sorafenib, imatinib, vatalanib",0.0530567293021746,0.0168249279621871,FALSE +"HCC15","Pearson.est","MDM inhibitor",0.43923,1.09,0.364,154,0.692,"nutlin.3, idasanutlin",0.438898616350944,0.159893905543242,FALSE +"HCC15","Pearson.est","MEK inhibitor",0.69964,1.72,0.0189,156,0.421,"cobimetinib, AZD8330, MEK162, TAK.733, AS.703026, trametinib, PD.0325901, Ro.4987655, selumetinib, MEK1.2.inhibitor",1.72353819582676,0.375717904164332,FALSE +"HCC15","Pearson.est","MET inhibitor",-0.62128,-1.69,0.0635,1099,0.34,"INC.280, AMG458, NVP.BVU972",1.19722627470802,0.468521082957745,FALSE +"HCC15","Pearson.est","microtubule inhibitor",-0.35202,-0.961,0.494,1358,0.729,"cytochalasin.b, estramustine.phosphate",0.306273051076353,0.137272471682025,FALSE +"HCC15","Pearson.est","mTOR inhibitor",0.2973,0.715,0.79,145,0.957,"GSK2126458, WAY.600, LY303511, XL388, OSI.027",0.102372908709559,0.0190880622231565,FALSE +"HCC15","Pearson.est","NFkB pathway inhibitor",0.52477,1.26,0.209,266,0.706,"curcumin, parthenolide...., bortezomib, Ro.106.9920, parthenolide",0.679853713888946,0.151195298948196,FALSE +"HCC15","Pearson.est","opioid receptor agonist",-0.40083,-1.06,0.395,578,0.626,"trimebutine, salvinorin.a, cebranopadol, ADL5859, BW.180C, spiradoline",0.40340290437354,0.20342566678957,FALSE +"HCC15","Pearson.est","p38 MAPK inhibitor",0.56299,1.34,0.153,583,0.642,"SB.242235, SB.239063, TAK.715, CMPD.1, talmapimod, VX.702",0.815308569182401,0.192464971931147,FALSE +"HCC15","Pearson.est","PARP inhibitor",-0.41383,-1.11,0.295,1235,0.612,"olaparib, AZD2461, E7449",0.530177984021837,0.213248577854439,FALSE +"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.19253,-0.522,0.959,1173,1,"crenolanib, lenvatinib, motesanib, tandutinib, trapidil, nintedanib, linifanib",0.0181813928293364,0,FALSE +"HCC15","Pearson.est","phosphatase inhibitor",0.50615,1.21,0.232,361,0.749,"GSK2830371, alexidine, CID.5458317, bis.maltolato.oxovanadium.IV., sodium.stibogluconate",0.6345120151091,0.125518182300534,FALSE +"HCC15","Pearson.est","phosphodiesterase inhibitor",-0.39081,-1.07,0.361,1157,0.644,"zardaverine, papaverine, GSK256066, YM.976, enoximone",0.442492798094342,0.191114132640188,FALSE +"HCC15","Pearson.est","PI3K inhibitor",0.35581,0.853,0.657,503,0.879,"buparlisib, YM.201636, GSK2126458, LY303511, TG.100713, taselisib, GDC.0941, PIK.75, AZD6482, CUDC.907, PF.04691502, pilaralisib, PF.05212384",0.182434630440219,0.0560111249262281,FALSE +"HCC15","Pearson.est","PLK inhibitor",-0.48448,-1.32,0.185,1111,0.757,"GSK461364, HMN.214, GW.843682X, BI.2536, volasertib",0.732828271596986,0.120904120499927,FALSE +"HCC15","Pearson.est","potassium channel blocker",-0.47471,-1.27,0.184,1267,0.616,"dofetilide, ML133",0.735182176990464,0.210419287835575,FALSE +"HCC15","Pearson.est","PPAR receptor agonist",-0.47031,-1.28,0.186,1108,0.662,"clofibrate, pterostilbene, ciprofibrate, GW.501516",0.730487055782084,0.1791420105603,FALSE +"HCC15","Pearson.est","progesterone receptor agonist",-0.50578,-1.35,0.136,1402,0.804,"dienogest, norgestrel",0.866461091629782,0.0947439512515487,FALSE +"HCC15","Pearson.est","proteasome inhibitor",0.4017,0.992,0.462,195,0.717,"carfilzomib, bortezomib",0.335358024443874,0.1444808443322,FALSE +"HCC15","Pearson.est","protein synthesis inhibitor",0.46752,1.11,0.346,417,0.679,"brefeldin.a, clindamycin.phosphate, chloramphenicol.palmitate, homoharringtonine, azomycin..2.nitroimidazole., cycloheximide, bruceantin, tedizolid.phosphate",0.460923901207223,0.168130225719498,FALSE +"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.46669,1.13,0.294,377,0.664,"AV.412, NVP.TAE226, PP.121",0.531652669587843,0.177831920631982,FALSE +"HCC15","Pearson.est","RAF inhibitor",0.63823,1.51,0.0622,200,0.557,"AZ.628, dabrafenib, vemurafenib, CEP.32496, LGX818, SB.590885",1.20620961530918,0.254144804826271,FALSE +"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.57362,1.37,0.125,406,0.751,"vandetanib, sunitinib, regorafenib, sorafenib",0.903089986991944,0.124360062995832,FALSE +"HCC15","Pearson.est","retinoid receptor agonist",0.71117,1.7,0.0219,194,0.322,"tamibarotene, CD.437, adarotene, AM.580",1.65955588515988,0.492144128304169,FALSE +"HCC15","Pearson.est","ribonucleotide reductase inhibitor",-0.40211,-1.11,0.309,1086,0.612,"pentostatin, fludarabine, cytarabine, hydroxyurea, clofarabine, gemcitabine",0.510041520575165,0.213248577854439,FALSE +"HCC15","Pearson.est","serotonin receptor agonist",-0.66371,-1.84,0.0226,1447,0.323,"aripiprazole",1.6458915608526,0.490797477668897,FALSE +"HCC15","Pearson.est","serotonin receptor antagonist",-0.31928,-0.892,0.58,1447,0.748,"aripiprazole",0.236572006437063,0.126098402135539,FALSE +"HCC15","Pearson.est","sodium channel blocker",-0.26782,-0.709,0.771,1276,0.858,"cibenzoline, lappaconite, oxcarbazepine",0.112945621949043,0.0665127121512946,FALSE +"HCC15","Pearson.est","src inhibitor",0.64064,1.56,0.0495,105,0.627,"saracatinib, dasatinib, ZM.306416, PP.2",1.30539480106643,0.202732459169284,FALSE +"HCC15","Pearson.est","sterol demethylase inhibitor",0.27717,0.669,0.855,465,0.972,"terconazole, sulconazole, lanoconazole",0.0680338852718274,0.0123337350737254,FALSE +"HCC15","Pearson.est","TGF beta receptor inhibitor",0.57039,1.37,0.15,66,0.751,"repsox, D.4476",0.823908740944319,0.124360062995832,FALSE +"HCC15","Pearson.est","thymidylate synthase inhibitor",0.53782,1.3,0.177,44,0.697,"carmofur",0.752026733638193,0.156767221901991,FALSE +"HCC15","Pearson.est","topoisomerase inhibitor",-0.63409,-1.75,0.0422,1117,0.341,"daunorubicin, epirubicin, camptothecin, rubitecan, valrubicin, amsacrine, teniposide, exatecan.mesylate, etoposide, idarubicin, nemorubicin, genz.644282, voreloxin, TAS.103, amonafide, mitoxantrone",1.37468754903833,0.467245621007502,FALSE +"HCC15","Pearson.est","tubulin polymerization inhibitor",0.23288,0.556,0.952,541,1,"nocodazole, indibulin, vindesine, vinorelbine, oxibendazole, podophyllotoxin, plinabulin, albendazole, mebendazole, vincristine, verubulin, parbendazole",0.0213630516155257,0,FALSE +"HCC15","Pearson.est","tyrosine kinase inhibitor",0.42549,1.03,0.423,406,0.736,"vandetanib, dasatinib, tivantinib, AV.412, NVP.TAE226, sunitinib, regorafenib, PP.121, sorafenib",0.373659632624958,0.133122185662501,FALSE +"HCC15","Pearson.est","VEGFR inhibitor",0.33429,0.801,0.715,320,0.877,"XL.647, vandetanib, ZM.306416, PD.173074, BMS.690514, MK.2461, lucitanib, sunitinib, regorafenib, ENMD.2076",0.145693958198919,0.0570004066339595,FALSE +"HCC15","Pearson.est","vitamin D receptor agonist",-0.27967,-0.753,0.734,403,0.89,"alfacalcidol, calcitriol, tacalcitol, ercalcitriol, paricalcitol, maxacalcitol, doxercalciferol",0.134303940083929,0.0506099933550872,FALSE diff --git a/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_venn_diagram.pdf b/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_venn_diagram.pdf new file mode 100644 index 0000000000000000000000000000000000000000..1ef26abc4a5283efe39a6f9c5bb83f9893d2930d GIT binary patch literal 7608 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+
+
+ + + + diff --git a/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_mean_results.csv b/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..8d70ace --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"estrogen receptor antagonist",1.00241666666667,0.696588891192885,0.124327712710528,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.265331768848105 +"RAF inhibitor",0.698,1.13162080060577,0.0047006947780887,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.0278684047558116 +"MEK inhibitor",0.667833333333333,1.60164357817685,5.08540197049992e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"H1650, H520, H460, H1299, H1703",0.000844176727102987 +"retinoid receptor agonist",0.610333333333333,1.03738520357968,0.171997633009449,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.339900084280579 +"HMGCR inhibitor",0.5195,1.9209607681385,8.5331314142516e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,7,"HCC95, H1975, H1648, H2126, H1299, HCC44, H1703",0.000395749475218249 +"MDM inhibitor",0.45425,1.52040958147946,0.00416580339781743,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1650, HCC95, H1648, H460",0.0265970524629882 +"glutamate receptor antagonist",0.43275,0.716226237111761,0.987358742586612,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"BCL inhibitor",0.425416666666667,1.05488159252232,0.304199929869937,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.515277432228669 +"dopamine receptor antagonist",0.4205,0.89417046371585,0.875993102824703,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"RET tyrosine kinase inhibitor",0.406416666666667,1.0790967989551,0.291163973828253,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.50697819475302 +"phosphatase inhibitor",0.393166666666667,0.983230744520175,0.513890846378439,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.804772457536046 +"thymidylate synthase inhibitor",0.353416666666667,1.40048059662216,4.67424917816275e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1650, H2126, HCC44",0.000844176727102987 +"FGFR inhibitor",0.32725,1.13192427669956,0.176518018039236,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.340720825517595 +"benzodiazepine receptor agonist",0.32275,0.573400562037965,0.999999744255947,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"Bcr.Abl kinase inhibitor",0.311416666666667,1.25046772764386,0.0259847661335041,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.0937711125687321 +"antioxidant",0.2925,1.39479633573573,0.0129712791125946,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.0616112951911576 +"Abl kinase inhibitor",0.2875,1.24619431579801,0.041043726324705,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.121665331605376 +"acetylcholine receptor agonist",0.236583333333333,0.981314559736844,0.770707396593526,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"cytochrome P450 inhibitor",0.232083333333333,1.30142770960716,0.0150124187360823,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.0655805660576229 +"proteasome inhibitor",0.221916666666667,1.25182531879966,0.0251527702555807,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0937711125687321 +"CC chemokine receptor antagonist",0.215916666666667,1.30495743283647,0.00678708773166565,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.0375552187818833 +"p38 MAPK inhibitor",0.213916666666667,1.20391123640886,0.094665808369185,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.218257280406732 +"adenosine receptor antagonist",0.185,1.38904735176831,0.00218259813041714,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H2126, H1299, H1703",0.0164686949840566 +"TGF beta receptor inhibitor",0.164,1.2726662063272,0.0381301100288775,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.117214782681364 +"adrenergic receptor agonist",0.142583333333333,0.841425031320874,0.992401426537453,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"FLT3 inhibitor",0.13425,1.09332463157106,0.410067230754878,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.667364316718723 +"bacterial DNA gyrase inhibitor",0.13425,1.03675017811341,0.684040247241143,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.946255675350247 +"HCV inhibitor",0.126916666666667,1.05333370852506,0.633163264300218,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646 +"sterol demethylase inhibitor",0.125583333333333,0.99504037911062,0.792730624396318,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"histamine receptor antagonist",0.113166666666667,0.67722251390022,0.999997961805646,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"growth factor receptor inhibitor",0.10475,1.26224044136535,0.0379479136146386,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.117214782681364 +"ALK tyrosine kinase receptor inhibitor",0.0668333333333333,1.01703542740952,0.741185677459224,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.999999744255948 +"EGFR inhibitor",0.058,1.84339055201895,3.20369112697271e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,7,"HCC95, H1975, H1648, H2126, H520, H1299, H1703",0.000844176727102987 +"mTOR inhibitor",0.0465833333333333,1.05096738625406,0.614580823363627,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646 +"glycogen synthase kinase inhibitor",0.0435,0.980106534098114,0.998823553215968,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.999999744255948 +"bromodomain inhibitor",0.04025,1.53547914493993,0.0340763504946138,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, A549",0.113133483642118 +"glucocorticoid receptor agonist",0.0339166666666667,1.29597309584401,0.0158476448165722,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0657677259887745 +"src inhibitor",0.0273333333333334,1.50636403503954,8.24951913546827e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"HCC95, H520, H1299, HCC44, H1703",0.00114118348040644 +"KIT inhibitor",0.0248333333333333,0.94747125965846,0.935832669479616,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"HDAC inhibitor",0.0211666666666666,1.1537745039914,0.293192209013795,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, A549",0.50697819475302 +"acetylcholine receptor antagonist",-0.00183333333333337,1.23950597441322,0.0779561053013444,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.200456681429326 +"estrogen receptor agonist",-0.00725000000000005,0.801671336532735,0.999452080686153,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"DNA inhibitor",-0.00916666666666668,0.931550694793202,0.966638581217711,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"progesterone receptor agonist",-0.0171666666666666,1.09721745862666,0.46373187184175,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.740187410824331 +"PI3K inhibitor",-0.0253333333333333,1.06693608339985,0.608568603424358,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646 +"tyrosine kinase inhibitor",-0.02975,1.00830380748156,0.811127303266585,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"DNA polymerase inhibitor",-0.0300833333333334,1.04827507305472,0.588924130380289,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646 +"DNA methyltransferase inhibitor",-0.0356666666666666,1.13077329400028,0.283229556884785,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.50697819475302 +"ribonucleotide reductase inhibitor",-0.0415000000000001,1.28968385837206,0.0329390189674143,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.113133483642118 +"opioid receptor agonist",-0.0475833333333333,1.23267303475255,0.0933508384303763,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.218257280406732 +"AP inhibitor",-0.0699166666666666,1.33192556837722,0.101268730435768,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1975, A549",0.227170395301859 +"PPAR receptor agonist",-0.0780833333333334,1.27135793245814,0.0627046999800293,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.167886777365885 +"NFkB pathway inhibitor",-0.0893333333333333,0.704062669386925,0.99998542119808,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"JAK inhibitor",-0.0970833333333334,1.01858515583969,0.812129700429645,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"AKT inhibitor",-0.119916666666667,1.24744243505978,0.0796996444237081,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H2126",0.200456681429326 +"phosphodiesterase inhibitor",-0.125833333333333,0.938912313974704,0.926782184949637,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"PDGFR tyrosine kinase receptor inhibitor",-0.1285,1.00276857658276,0.762426676890818,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"protein tyrosine kinase inhibitor",-0.166416666666667,1.3955663860522,0.000996752902459099,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H1648, H2126",0.0103413113630132 +"CDK inhibitor",-0.201916666666667,1.16107743523249,0.0941930017532901,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.218257280406732 +"CHK inhibitor",-0.209583333333333,1.18310919025279,0.204180911811555,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.385159447280888 +"protein synthesis inhibitor",-0.248833333333333,1.17580137726909,0.140001294478339,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.290502686042554 +"serotonin receptor antagonist",-0.263916666666667,1.03078244405388,0.624882064154891,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646 +"VEGFR inhibitor",-0.2715,0.741741868846568,0.999534634664959,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"calcium channel blocker",-0.27525,0.937528775315966,0.866095767459057,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"adrenergic receptor antagonist",-0.275916666666667,0.770525494632584,0.998631425519013,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"androgen receptor antagonist",-0.29825,1.28566609018615,0.0133614857041065,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, A549, HCC15",0.0616112951911576 +"bacterial 50S ribosomal subunit inhibitor",-0.31975,0.987198158702423,0.630216737456706,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646 +"Aurora kinase inhibitor",-0.37975,1.24472122654761,0.0085197872386698,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0441963963005996 +"PARP inhibitor",-0.394416666666667,1.1955539954601,0.044614158385556,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.127688798137971 +"DNA alkylating agent",-0.401166666666667,0.901674486046865,0.846215198379105,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"potassium channel blocker",-0.408,1.0340825534128,0.399605399146996,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.663344962584014 +"sodium channel blocker",-0.409833333333333,0.682226013380708,0.998626395757675,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"DNA synthesis inhibitor",-0.438166666666667,1.10393995499865,0.226980227883247,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.41865242031799 +"vitamin D receptor agonist",-0.442416666666667,1.55978701683236,0.0206707016748029,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1648, H2126, H1299",0.08169848757184 +"MET inhibitor",-0.4645,1.14146233960095,0.165128270570095,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.334284059934583 +"cyclooxygenase inhibitor",-0.46875,0.609628370402822,0.999158830773346,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948 +"tubulin polymerization inhibitor",-0.49775,1.28656894844035,0.00133279142519831,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H2126, H1299",0.012291298699051 +"PLK inhibitor",-0.596666666666667,1.47931392779548,9.53613193296986e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H460, H1299",0.000395749475218249 +"microtubule inhibitor",-0.613833333333333,1.17771124978867,0.00249951164829279,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H2126, H460, H1299",0.0172882889006918 +"topoisomerase inhibitor",-0.66875,1.22133058029497,0.00183574463749805,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1299, H1703",0.0152366804912338 +"ATPase inhibitor",-0.752666666666667,1.00384717537838,0.0468005257141872,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1299",0.129481454475918 +"serotonin receptor agonist",-0.81,1.27959148310559,0.00014168317666895,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1975",0.00167995766621755 +"HSP inhibitor",-0.958416666666667,0.69444293676604,0.124673963675616,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.265331768848105 diff --git a/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_results.csv b/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_results.csv new file mode 100644 index 0000000..6cd3803 --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_results.csv @@ -0,0 +1,997 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"H1650","Pearson.est","EGFR inhibitor",-0.18808,-0.582,0.967,1165,0.95,"AZD8931, TAK.285, FERb.033, WZ8040, icotinib, WZ.3146, BMS.599626, neratinib, rociletinib, ARRY.334543, CP.724714, lapatinib, osimertinib, PD.168393, GW.583340, brigatinib, canertinib, BMS.690514, tucatinib",0.0145735259169983,0.0222763947111523,FALSE +"H1650","Pearson.est","Abl kinase inhibitor",0.54126,1.27,0.168,427,0.685,"KW.2449, GZD824, tozasertib, bafetinib, ponatinib, nilotinib, flumatinib",0.774690718274137,0.164309428507574,FALSE +"H1650","Pearson.est","acetylcholine receptor agonist",0.55053,1.31,0.143,550,0.745,"oxiracetam, tremorine, pilocarpine, xanomeline, nicotine",0.844663962534938,0.127843727251707,FALSE +"H1650","Pearson.est","acetylcholine receptor antagonist",-0.52982,-1.61,0.0464,764,0.393,"hyoscyamine, iododexetimide, dicycloverine, diphemanil, methscopolamine, darifenacin",1.33348201944512,0.405607449624573,FALSE +"H1650","Pearson.est","adenosine receptor antagonist",0.45164,1.08,0.365,328,0.885,"istradefylline, sulmazole, PSB.1115, SCH.58261",0.437707135543525,0.0530567293021746,FALSE +"H1650","Pearson.est","adrenergic receptor agonist",-0.19853,-0.624,0.915,1447,0.978,"xylazine",0.0385789059335517,0.00966114521239857,FALSE +"H1650","Pearson.est","adrenergic receptor antagonist",0.34548,0.829,0.694,317,1,"oxprenolol, carvedilol, atipamezole, atenolol......, idazoxan",0.158640529545145,0,FALSE +"H1650","Pearson.est","AKT inhibitor",-0.31037,-0.9,0.587,446,0.645,"palomid.529, ONC201, uprosertib, AT7867, AZD5363, MK.2206, triciribine, GSK2110183, CCT128930, A.674563, GDC.0068",0.231361898752386,0.190440285364732,FALSE +"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.39974,0.947,0.545,510,0.988,"AZD3463, alectinib, DMH1, lorlatinib, CEP.37440",0.263603497723358,0.00524305541237188,FALSE +"H1650","Pearson.est","androgen receptor antagonist",-0.35563,-1.06,0.35,1234,0.475,"enzalutamide, flutamide, RU.58841",0.455931955649724,0.323306390375133,FALSE +"H1650","Pearson.est","antioxidant",0.45589,1.07,0.398,231,0.854,"mesna, trolox",0.400116927926312,0.068542129310995,FALSE +"H1650","Pearson.est","AP inhibitor",-0.45002,-1.36,0.109,1216,0.526,"LCL.161, tanshinone.i, birinapant, GDC.0152",0.962573502059376,0.279014255846261,FALSE +"H1650","Pearson.est","ATPase inhibitor",-0.44453,-1.42,0.109,1318,0.559,"rabeprazole, digitoxigenin, oligomycin.a, omeprazole, k.strophanthidin",0.962573502059376,0.252588192113577,FALSE +"H1650","Pearson.est","Aurora kinase inhibitor",0.56442,1.33,0.124,533,0.729,"GSK1070916, SNS.314, KW.2449, tozasertib, AT.9283, danusertib, hesperadin, alisertib, CCT129202, AMG900, barasertib, barasertib.HQPA, ENMD.2076, CCT137690, PHA.680632, PF.03814735, MK.8745, MK.5108",0.906578314837765,0.137272471682025,FALSE +"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.30728,0.734,0.824,684,1,"valnemulin, tedizolid, tilmicosin, azalomycin.b, azithromycin",0.0840727883028842,0,FALSE +"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.53356,1.27,0.178,146,0.685,"finafloxacin, novobiocin",0.749579997691106,0.164309428507574,FALSE +"H1650","Pearson.est","BCL inhibitor",0.51208,1.23,0.202,224,0.693,"gossypol, TW.37, obatoclax",0.694648630553376,0.159266765388193,FALSE +"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.51671,1.23,0.209,427,0.693,"GZD824, tozasertib, bafetinib, ponatinib, nilotinib, flumatinib",0.679853713888946,0.159266765388193,FALSE +"H1650","Pearson.est","benzodiazepine receptor agonist",0.17413,0.42,0.991,706,0.995,"zaleplon, ZK.93423, lorazepam, ivermectin, eprinomectin, temazepam",0.00392634551472468,0.00217691925427455,FALSE +"H1650","Pearson.est","bromodomain inhibitor",0.49653,1.21,0.228,732,0.686,"bromosporine, I.BET.762, JQ1...., PFI.1, I.BET151, OTX015",0.642065152999546,0.163675884293248,FALSE +"H1650","Pearson.est","calcium channel blocker",0.33933,0.813,0.723,342,1,"tetrandrine, cinnarazine, mibefradil",0.140861702705469,0,FALSE +"H1650","Pearson.est","CC chemokine receptor antagonist",0.70818,1.69,0.0131,233,0.17,"navarixin, ZK811752, PF.04136309, SB.225002",1.88272870434424,0.769551078621726,TRUE +"H1650","Pearson.est","CDK inhibitor",0.69186,1.64,0.0126,248,0.214,"palbociclib, AZD5438, ribociclib, indisulam, abemaciclib, alvocidib, PHA.848125, JNJ.7706621, TG.02, aminopurvalanol.a, dinaciclib, P276.00",1.89962945488244,0.669586226650809,TRUE +"H1650","Pearson.est","CHK inhibitor",-0.43234,-1.3,0.196,623,0.514,"SB.218078, AZD7762, CHIR.124, LY2606368, SCH.900776, LY2603618, PF.477736",0.707743928643524,0.289036881004724,FALSE +"H1650","Pearson.est","cyclooxygenase inhibitor",0.2703,0.644,0.904,453,1,"tepoxalin, meloxicam, FR.122047, ketoprofen, curcumin, aspirin, piroxicam, indoprofen",0.0438315695246367,0,FALSE +"H1650","Pearson.est","cytochrome P450 inhibitor",0.44419,1.05,0.399,486,0.854,"morin, itraconazole, cobicistat",0.399027104313252,0.068542129310995,FALSE +"H1650","Pearson.est","DNA alkylating agent",0.43944,1.04,0.411,482,0.854,"carmustine, melphalan, cyclophosphamide, carboplatin, temozolomide, TH.302, streptozotocin",0.386158178123931,0.068542129310995,FALSE +"H1650","Pearson.est","DNA inhibitor",0.39707,0.941,0.549,395,0.976,"carmustine, oxaliplatin, melphalan, carboplatin, mechlorethamine, sangivamycin, bendamustine",0.260427655549908,0.0105501823333082,FALSE +"H1650","Pearson.est","DNA methyltransferase inhibitor",0.27229,0.654,0.901,653,1,"fdcyd, disulfiram, decitabine, RG108",0.045275209020937,0,FALSE +"H1650","Pearson.est","DNA polymerase inhibitor",0.47391,1.13,0.323,457,0.77,"idoxuridine, trifluridine, adefovir.dipivoxil, foscarnet, famciclovir",0.490797477668897,0.113509274827518,FALSE +"H1650","Pearson.est","DNA synthesis inhibitor",0.44794,1.07,0.392,226,0.854,"anisomycin, floxuridine, cyclocytidine, CB.10.277",0.406713932979543,0.068542129310995,FALSE +"H1650","Pearson.est","dopamine receptor antagonist",0.46674,1.13,0.311,280,0.77,"domperidone, amisulpride, UH.232...., sertindole, paliperidone, isofloxythepin, mesoridazine",0.507239610973163,0.113509274827518,FALSE +"H1650","Pearson.est","estrogen receptor agonist",0.30122,0.715,0.842,481,1,"PPT, estrone, erteberel, ethinyl.estradiol",0.0746879085003505,0,FALSE +"H1650","Pearson.est","estrogen receptor antagonist",0.52217,1.22,0.218,456,0.689,"raloxifene, clomifene, fulvestrant",0.661543506395395,0.161780778092374,FALSE +"H1650","Pearson.est","FGFR inhibitor",0.38321,0.91,0.587,378,0.975,"regorafenib, PD.173074, dovitinib",0.231361898752386,0.0109953843014632,FALSE +"H1650","Pearson.est","FLT3 inhibitor",0.57249,1.36,0.113,436,0.838,"gilteritinib, KW.2449, tozasertib, ponatinib, TG.02, pacritinib, lestaurtinib, TG.101348, ENMD.2076, dovitinib, sunitinib",0.94692155651658,0.0767559813697235,FALSE +"H1650","Pearson.est","glucocorticoid receptor agonist",0.55703,1.34,0.137,407,0.758,"hydrocortisone, prednisolone, ciclesonide, fluocinolone.acetonide, triamcinolone.acetonide, rimexolone, halobetasol.propionate, difluprednate, methylprednisolone, desonide, fluticasone.propionate, flumethasone.pivalate, halcinonide, triamcinolone, prednisolone.acetate",0.863279432843593,0.120330794367946,FALSE +"H1650","Pearson.est","glutamate receptor antagonist",0.29918,0.714,0.843,160,1,"diazooxonorleucine, SIB.1757",0.0741724253752577,0,FALSE +"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.3524,0.848,0.669,615,1,"tideglusib, TWS.119, CHIR.99021, kenpaullone, AZD2858",0.174573882232177,0,FALSE +"H1650","Pearson.est","growth factor receptor inhibitor",0.65866,1.57,0.0297,327,0.304,"GSK1838705A, AZD3463, PHA.848125, danusertib, lestaurtinib, GSK1904529A",1.52724355068279,0.517126416391246,FALSE +"H1650","Pearson.est","HCV inhibitor",0.41615,0.992,0.493,600,0.927,"embelin, PSI.7976, mericitabine",0.30715308072277,0.0329202658555029,FALSE +"H1650","Pearson.est","HDAC inhibitor",0.22243,0.543,0.952,555,1,"PCI.24781, givinostat, trichostatin.a, panobinostat, AR.42, resminostat, belinostat, entinostat, dacinostat, R306465",0.0213630516155257,0,FALSE +"H1650","Pearson.est","histamine receptor antagonist",0.2411,0.575,0.951,923,1,"pheniramine, astemizole, tiotidine, ranitidine, ICI.162846, epinastine, BF2.649, zolantidine, levocetirizine, famotidine, tecastemizole, cimetidine, nizatidine, cyproheptadine",0.0218194830625861,0,FALSE +"H1650","Pearson.est","HMGCR inhibitor",-0.41401,-1.27,0.195,597,0.413,"lovastatin, simvastatin, atorvastatin, mevastatin, fluvastatin, pitavastatin",0.709965388637482,0.384049948343599,FALSE +"H1650","Pearson.est","HSP inhibitor",-0.35367,-1.07,0.323,1294,0.502,"VER.49009, tanespimycin, guanidine, alvespimycin, KW.2478",0.490797477668897,0.299296282854981,FALSE +"H1650","Pearson.est","JAK inhibitor",0.49631,1.18,0.27,431,0.713,"atiprimod, TG.101209, tozasertib, AZ960, TG.02, AT.9283, pacritinib, lestaurtinib, TG.101348, AZD1480, filgotinib",0.568636235841013,0.146910470148134,FALSE +"H1650","Pearson.est","KIT inhibitor",0.39485,0.928,0.566,149,0.958,"KI.8751, regorafenib, OSI.930",0.247183568811729,0.0186344909214556,FALSE +"H1650","Pearson.est","MDM inhibitor",0.82133,1.94,0,180,0.0323,"idasanutlin, nutlin.3, serdemetan, CGM097, AMG.232",Inf,1.4907974776689,TRUE +"H1650","Pearson.est","MEK inhibitor",0.86838,2.1,0,96,0.00468,"cobimetinib, AZD8330, AS.703026, PD.0325901, trametinib, TAK.733, MEK162, Ro.4987655, selumetinib, PD.318088, refametinib, PD.198306, PD.184352",Inf,2.32975414692588,TRUE +"H1650","Pearson.est","MET inhibitor",0.33916,0.808,0.71,678,1,"PHA.665752, LY2801653, AMG458",0.148741651280925,0,FALSE +"H1650","Pearson.est","microtubule inhibitor",0.31595,0.756,0.796,608,1,"vinflunine, podophyllotoxin, vinblastine, D.64131, triclabendazole, secnidazole",0.0990869322623309,0,FALSE +"H1650","Pearson.est","mTOR inhibitor",0.36306,0.853,0.689,463,1,"XL388, WAY.600, ku.0063794, LY303511, WYE.354, torin.1, PF.04691502, PP242, OSI.027, palomid.529, GSK2126458, voxtalisib, AZD8055",0.161780778092374,0,FALSE +"H1650","Pearson.est","NFkB pathway inhibitor",0.27807,0.663,0.89,621,1,"bortezomib, curcumin, betulinic.acid, parthenolide...., EVP4593, parthenolide",0.0506099933550872,0,FALSE +"H1650","Pearson.est","opioid receptor agonist",0.49789,1.18,0.251,562,0.713,"trimebutine, salvinorin.a, cebranopadol",0.600326278518962,0.146910470148134,FALSE +"H1650","Pearson.est","p38 MAPK inhibitor",0.44356,1.06,0.401,696,0.854,"skepinone.l, SB.242235, VX.702, TAK.715, CMPD.1",0.396855627379818,0.068542129310995,FALSE +"H1650","Pearson.est","PARP inhibitor",0.54492,1.29,0.159,333,0.707,"talazoparib, niraparib, AG.14361",0.798602875679548,0.150580586203101,FALSE +"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.23349,0.561,0.949,448,1,"KI.8751, regorafenib, ponatinib, dovitinib, sunitinib, crenolanib",0.0227337875727074,0,FALSE +"H1650","Pearson.est","phosphatase inhibitor",0.24877,0.592,0.941,225,1,"GSK2830371, sodium.stibogluconate",0.0264103765727431,0,FALSE +"H1650","Pearson.est","phosphodiesterase inhibitor",-0.33171,-0.984,0.428,477,0.553,"avanafil, GSK256066, EMD.53998, anagrelide, zardaverine, cilostamide, YM.976, trequinsin, papaverine, enoximone",0.368556230986828,0.257274868695302,FALSE +"H1650","Pearson.est","PI3K inhibitor",0.3958,0.931,0.564,503,0.975,"YM.201636, LY303511, buparlisib, PIK.75, ZSTK.474, GDC.0941, AZD6482, PF.04691502, GSK2126458, voxtalisib, TG.100713",0.248720896016658,0.0109953843014632,FALSE +"H1650","Pearson.est","PLK inhibitor",0.62742,1.48,0.0734,296,0.487,"rigosertib, NMS.1286937, volasertib, GSK461364",1.13430394008393,0.312471038785366,FALSE +"H1650","Pearson.est","potassium channel blocker",-0.38488,-1.18,0.252,555,0.485,"meglitinide, oleoylethanolamide, ML133, ibutilide, mepivacaine, dofetilide",0.598599459218456,0.314258261397736,FALSE +"H1650","Pearson.est","PPAR receptor agonist",-0.38793,-1.15,0.265,559,0.477,"ciprofibrate, oleoylethanolamide, fenofibrate, clofibrate, S26948, pterostilbene, GW.501516",0.576754126063192,0.321481620959886,FALSE +"H1650","Pearson.est","progesterone receptor agonist",0.32588,0.774,0.755,426,1,"melengestrol.acetate, nomegestrol.acetate, tanaproget",0.122053048370812,0,FALSE +"H1650","Pearson.est","proteasome inhibitor",0.20868,0.498,0.979,563,1,"bortezomib, ixazomib, MG.132",0.00921730819686218,0,FALSE +"H1650","Pearson.est","protein synthesis inhibitor",0.41826,0.988,0.493,120,0.912,"brefeldin.a, cycloheximide, homoharringtonine",0.30715308072277,0.0400051616715838,FALSE +"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.29662,0.699,0.842,57,1,"NVP.TAE226",0.0746879085003505,0,FALSE +"H1650","Pearson.est","RAF inhibitor",0.74518,1.76,0.00585,144,0.106,"AZ.628, dabrafenib, CEP.32496, GDC.0879, LGX818, SB.590885, vemurafenib, regorafenib",2.23284413391782,0.97469413473523,TRUE +"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.48011,1.14,0.284,670,0.801,"regorafenib, sunitinib, sorafenib, vandetanib",0.546681659952962,0.0963674839157623,FALSE +"H1650","Pearson.est","retinoid receptor agonist",0.4206,1,0.482,281,0.933,"tamibarotene, CD.437, adarotene",0.31695296176115,0.0301183562535,FALSE +"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.54497,1.3,0.165,331,0.723,"LY2334737, triapine, clofarabine, fludarabine.phosphate, cladribine",0.782516055786094,0.140861702705469,FALSE +"H1650","Pearson.est","serotonin receptor agonist",0.28963,0.693,0.849,855,1,"NAN.190, ipsapirone, aripiprazole, SR.57227A, zolmitriptan",0.0710923097560473,0,FALSE +"H1650","Pearson.est","serotonin receptor antagonist",0.55315,1.34,0.126,274,0.758,"pirenperone, sertindole, paliperidone, SB.216641, SB.200646, lerisetron",0.899629454882437,0.120330794367946,FALSE +"H1650","Pearson.est","sodium channel blocker",0.32985,0.785,0.75,419,1,"ajmaline, mexiletine, benzethonium, quinidine, butamben",0.1249387366083,0,FALSE +"H1650","Pearson.est","src inhibitor",0.27796,0.668,0.891,51,1,"PP.2",0.0501222959631252,0,FALSE +"H1650","Pearson.est","sterol demethylase inhibitor",-0.38003,-1.13,0.256,548,0.455,"terconazole, posaconazole, lanoconazole, ketoconazole, sulconazole, chlormidazole",0.59176003468815,0.341988603342888,FALSE +"H1650","Pearson.est","TGF beta receptor inhibitor",-0.42718,-1.28,0.155,616,0.464,"SB.525334, D.4476, adaprev, SB.431542, repsox, LY2109761",0.809668301829709,0.333482019445119,FALSE +"H1650","Pearson.est","thymidylate synthase inhibitor",0.75588,1.79,0.0034,295,0.109,"carmofur, raltitrexed, trifluridine, ftorafur",2.46852108295775,0.962573502059376,TRUE +"H1650","Pearson.est","topoisomerase inhibitor",0.38246,0.899,0.601,681,0.976,"amsacrine, topotecan, fleroxacin, idarubicin, voreloxin, teniposide, TAS.103, SN.38, exatecan.mesylate, rubitecan, daunorubicin, valrubicin, nemorubicin, doxorubicin, genz.644282, licochalcone.a",0.22112552799726,0.0105501823333082,FALSE +"H1650","Pearson.est","tubulin polymerization inhibitor",0.52319,1.25,0.206,479,0.706,"verubulin, indibulin, albendazole, fosbretabulin, oxibendazole, parbendazole, podophyllotoxin, nocodazole, vindesine, vinorelbine, vinblastine, epothilone.b, BNC105, combretastatin.A.4, taltobulin, plinabulin, vincristine, dolastatin.10",0.686132779630847,0.151195298948196,FALSE +"H1650","Pearson.est","tyrosine kinase inhibitor",0.31444,0.758,0.769,708,1,"NVP.TAE226, regorafenib, bafetinib, aminopurvalanol.a, tivantinib, UNC2250, sunitinib, tyrphostin.A9, PP.121, hypericin, sorafenib, vandetanib, dasatinib",0.114073660198569,0,FALSE +"H1650","Pearson.est","VEGFR inhibitor",0.19227,0.457,0.983,796,1,"KI.8751, regorafenib, OSI.930, PD.173074, ENMD.2076, TG.100572, dovitinib, sunitinib, RAF265, sorafenib, golvatinib, vandetanib, axitinib, semaxanib, MK.2461, SAR131675, orantinib, vatalanib, pazopanib",0.00744648216786438,0,FALSE +"H1650","Pearson.est","vitamin D receptor agonist",-0.51224,-1.63,0.0192,1326,0.725,"calcitriol, maxacalcitol",1.71669877129645,0.139661993429006,FALSE +"HCC95","Pearson.est","EGFR inhibitor",-0.82172,-2.01,0,1330,0.0316,"CNX.2006, CUDC.101, TAK.285, PD.168393, GW.583340, BMS.599626, WZ8040, brigatinib, AST.1306, WZ.3146, icotinib, WZ.4002, BIBX.1382, ARRY.334543, CP.724714, AEE788, pelitinib, BMS.690514, tucatinib, rociletinib, lapatinib, neratinib, AZD8931, dacomitinib, osimertinib, erlotinib, XL.647, gefitinib, afatinib, canertinib, poziotinib",Inf,1.5003129173816,TRUE +"HCC95","Pearson.est","Abl kinase inhibitor",-0.37517,-0.915,0.568,1227,0.85,"metatinib, bosutinib, ZM.306416",0.245651664288981,0.0705810742857073,FALSE +"HCC95","Pearson.est","acetylcholine receptor agonist",0.52402,1.42,0.135,407,0.303,"tremorine, nefiracetam, oxiracetam, nicotine, pilocarpine",0.869666231504994,0.518557371497695,FALSE +"HCC95","Pearson.est","acetylcholine receptor antagonist",0.46524,1.29,0.161,19,0.395,"iododexetimide",0.79317412396815,0.40340290437354,FALSE +"HCC95","Pearson.est","adenosine receptor antagonist",-0.54128,-1.33,0.147,1443,0.455,"CGS.15943",0.832682665251824,0.341988603342888,FALSE +"HCC95","Pearson.est","adrenergic receptor agonist",0.37474,1.03,0.411,386,0.558,"ritodrine, isoxsuprine, isoetharine, oxymetazoline, norepinephrine, epinephrine, xylazine",0.386158178123931,0.253365801062421,FALSE +"HCC95","Pearson.est","adrenergic receptor antagonist",-0.22971,-0.571,0.932,1081,1,"dihydroergocristine, vincamine, carvedilol, RS.17053, imiloxan",0.0305840876460186,0,FALSE +"HCC95","Pearson.est","AKT inhibitor",-0.60551,-1.45,0.0902,1305,0.361,"CCT128930, GDC.0068, triciribine, uprosertib",1.04479346245806,0.442492798094342,FALSE +"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.73298,-1.78,0.0147,1246,0.134,"SB.505124, CEP.37440, alectinib, NVP.TAE684, AZD3463, brigatinib",1.83268266525182,0.872895201635192,TRUE +"HCC95","Pearson.est","androgen receptor antagonist",0.63795,1.67,0.0458,222,0.201,"bicalutamide, enzalutamide",1.33913452199613,0.696803942579511,TRUE +"HCC95","Pearson.est","antioxidant",0.74347,2.06,0,200,0.0553,"benfotiamine, chlorogenic.acid, trolox, mesna",Inf,1.2572748686953,TRUE +"HCC95","Pearson.est","AP inhibitor",0.41269,1.15,0.277,22,0.442,"idronoxil",0.557520230935551,0.354577730650908,FALSE +"HCC95","Pearson.est","ATPase inhibitor",-0.5272,-1.27,0.186,1057,0.497,"digitoxigenin, omeprazole, evodiamine, digoxin, oligomycin.a, NMS.873, k.strophanthidin, rabeprazole",0.730487055782084,0.303643611266668,FALSE +"HCC95","Pearson.est","Aurora kinase inhibitor",-0.65344,-1.59,0.0318,1085,0.271,"barasertib, GSK1070916, CCT137690, PF.03814735, MK.5108, alisertib, aurora.a.inhibitor.i, ENMD.2076, CCT129202, hesperadin, MLN.8054, MK.8745, CYC116, ZM.447439, TAK.901, danusertib, barasertib.HQPA, PHA.680632",1.49757288001557,0.567030709125594,FALSE +"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.45658,-1.12,0.318,1024,0.646,"tedizolid, valnemulin, azithromycin, radezolid",0.497572880015567,0.189767482004916,FALSE +"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.56518,1.58,0.0733,116,0.225,"nadifloxacin, novobiocin, sparfloxacin",1.13489602535887,0.647817481888638,FALSE +"HCC95","Pearson.est","BCL inhibitor",0.53749,1.47,0.107,400,0.279,"oridonin, venetoclax, ABT.737, navitoclax, gossypol",0.97061622231479,0.554395796726402,FALSE +"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.24612,-0.59,0.909,1227,1,"metatinib, bosutinib",0.0414361167780325,0,FALSE +"HCC95","Pearson.est","benzodiazepine receptor agonist",-0.20328,-0.498,0.981,1064,1,"ZK.93423, ivermectin, bentazepam",0.0083309926200515,0,FALSE +"HCC95","Pearson.est","bromodomain inhibitor",-0.5225,-1.3,0.193,1029,0.463,"JQ1...., I.BET151, OTX015, I.BET.762",0.714442690992226,0.334419008982047,FALSE +"HCC95","Pearson.est","calcium channel blocker",-0.42758,-1.06,0.373,873,0.691,"tetrandrine, fendiline, carboxyamidotriazole, efonidipine.monoethanolate, penfluridol",0.428291168191312,0.160521952625802,FALSE +"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.25951,-0.63,0.906,1044,1,"MK.0812, SB.225002, ZK811752",0.0428718023231869,0,FALSE +"HCC95","Pearson.est","CDK inhibitor",-0.60637,-1.47,0.0849,1012,0.386,"CR8..R., ribociclib, palbociclib, PHA.848125, dinaciclib, alvocidib, TG.02, aminopurvalanol.a, R547, arcyriaflavin.a, JNJ.7706621, indisulam, BMS.265246, PHA.793887, BMS.387032, AT.7519",1.07109230975605,0.413412695328245,FALSE +"HCC95","Pearson.est","CHK inhibitor",-0.39923,-0.975,0.489,765,0.784,"AZD7762, PF.477736, CHIR.124, LY2603618, SB.218078",0.31069114087638,0.105683937315562,FALSE +"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.1866,-0.455,0.991,787,1,"indoprofen, sulfasalazine, curcumin, piroxicam, aspirin, phenazone, FR.122047, ramifenazone, FK.3311, tryptanthrin, amfenac",0.00392634551472468,0,FALSE +"HCC95","Pearson.est","cytochrome P450 inhibitor",0.62507,1.79,0.0261,181,0.167,"metyrapone, morin, clotrimazole",1.58335949266172,0.777283528852417,TRUE +"HCC95","Pearson.est","DNA alkylating agent",-0.28241,-0.687,0.819,1096,1,"cyclophosphamide, mitomycin.c, estramustine, dacarbazine",0.0867160982395816,0,FALSE +"HCC95","Pearson.est","DNA inhibitor",0.37521,1.02,0.411,248,0.524,"nimorazole, metronidazole, carboplatin, bendamustine, pibenzimol, nithiamide, carmustine",0.386158178123931,0.280668713016273,FALSE +"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.66148,-1.59,0.042,1146,0.271,"fdcyd, SGI.1027, azacitidine, decitabine",1.3767507096021,0.567030709125594,FALSE +"HCC95","Pearson.est","DNA polymerase inhibitor",-0.2787,-0.678,0.859,1380,1,"cephalomannine",0.0660068361687577,0,FALSE +"HCC95","Pearson.est","DNA synthesis inhibitor",-0.41843,-1.03,0.427,1211,0.727,"mitomycin.c, anisomycin, cyclocytidine, enocitabine",0.369572124974976,0.138465589140962,FALSE +"HCC95","Pearson.est","dopamine receptor antagonist",0.22873,0.63,0.87,144,1,"amisulpride, clebopride, ziprasidone",0.0604807473813815,0,FALSE +"HCC95","Pearson.est","estrogen receptor agonist",-0.3061,-0.738,0.765,1362,1,"levonorgestrel",0.116338564846382,0,FALSE +"HCC95","Pearson.est","estrogen receptor antagonist",0.42984,1.18,0.257,92,0.428,"danazol, toremifene",0.590066876668705,0.368556230986828,FALSE +"HCC95","Pearson.est","FGFR inhibitor",0.21958,0.616,0.898,202,0.977,"erdafitinib, orantinib",0.0467236633326956,0.0101054362812269,FALSE +"HCC95","Pearson.est","FLT3 inhibitor",0.20475,0.556,0.962,397,0.987,"GTP.14564, ponatinib, gilteritinib, midostaurin, KW.2449, dovitinib, tyrphostin.AG.1296, tandutinib",0.0168249279621871,0.00568284733036327,FALSE +"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.40631,-0.988,0.459,1001,0.784,"betamethasone, methylprednisolone, halcinonide, difluprednate, clobetasol.propionate, flumethasone.pivalate, deflazacort, beclomethasone.dipropionate, triamcinolone.acetonide, halobetasol.propionate, ciclesonide, flumethasone, fluorometholone",0.338187314462739,0.105683937315562,FALSE +"HCC95","Pearson.est","glutamate receptor antagonist",-0.17529,-0.424,0.997,1344,0.995,"LY456236",0.00130484168834428,0.00217691925427455,FALSE +"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.73408,2.03,0,130,0.0522,"CHIR.98014, CHIR.99021, GSK.3.inhibitor.IX, tideglusib, LY2090314",Inf,1.28232949699774,TRUE +"HCC95","Pearson.est","growth factor receptor inhibitor",-0.55436,-1.33,0.161,935,0.455,"lestaurtinib, PHA.848125, GSK1838705A, danusertib, AZD3463",0.79317412396815,0.341988603342888,FALSE +"HCC95","Pearson.est","HCV inhibitor",0.24965,0.668,0.869,1088,0.993,"Ro.9187, embelin, mericitabine, daclatasvir, PSI.7976, narlaprevir",0.0609802235513335,0.00305075150461883,FALSE +"HCC95","Pearson.est","HDAC inhibitor",-0.38257,-0.928,0.537,847,0.851,"resminostat, R306465, RGFP966, chidamide, AR.42, belinostat, ACY.1215, M.344, trichostatin.a, NSC.3852, scriptaid, vorinostat, PCI.24781, JNJ.26481585, givinostat, dacinostat, SB.939",0.270025714300444,0.0700704399154121,FALSE +"HCC95","Pearson.est","histamine receptor antagonist",0.12867,0.35,1,1264,1,"epinastine, lafutidine, chloropyramine, nizatidine, famotidine, ICI.162846, cimetidine, pheniramine, tecastemizole, astemizole, ranitidine, tiotidine, cyproheptadine, zolantidine, BF2.649, terfenadine, levocetirizine, ebastine",0,0,FALSE +"HCC95","Pearson.est","HMGCR inhibitor",0.9154,2.5,0,128,0,"lovastatin, pitavastatin, fluvastatin, mevastatin, atorvastatin, simvastatin",Inf,Inf,TRUE +"HCC95","Pearson.est","HSP inhibitor",-0.58608,-1.4,0.116,931,0.375,"ganetespib, XL888, VER.49009, alvespimycin, NVP.AUY922, BIIB021, KW.2478, tanespimycin, PU.H71",0.935542010773082,0.425968732272281,FALSE +"HCC95","Pearson.est","JAK inhibitor",-0.53095,-1.31,0.193,1008,0.468,"baricitinib, AT.9283, LY2784544, WHI.P154, TG.02, AZD1480, ruxolitinib, AZ960, pacritinib, filgotinib, PRT062070",0.714442690992226,0.329754146925876,FALSE +"HCC95","Pearson.est","KIT inhibitor",-0.19135,-0.465,0.993,1033,1,"lenvatinib, vatalanib, cediranib, OSI.930",0.00305075150461883,0,FALSE +"HCC95","Pearson.est","MDM inhibitor",0.85188,2.36,0,71,0.00404,"AMG.232, idasanutlin, CGM097, nutlin.3",Inf,2.3936186348894,TRUE +"HCC95","Pearson.est","MEK inhibitor",0.43088,1.18,0.267,392,0.428,"refametinib, BIX.02188, cobimetinib, U.0126, TAK.733, MEK1.2.inhibitor, PD.184352, MEK162",0.573488738635425,0.368556230986828,FALSE +"HCC95","Pearson.est","MET inhibitor",0.60658,1.68,0.0458,213,0.226,"PHA.665752, NVP.BVU972, AMG458",1.33913452199613,0.645891560852599,TRUE +"HCC95","Pearson.est","microtubule inhibitor",-0.59596,-1.46,0.0804,1139,0.373,"podophyllotoxin, colchicine, vinflunine, cabazitaxel, D.64131",1.09474395125155,0.428291168191312,FALSE +"HCC95","Pearson.est","mTOR inhibitor",-0.45945,-1.12,0.329,1056,0.646,"PP242, torin.1, MLN0128, WYE.125132, torin.2, deforolimus, AZD8055, PI.103, GDC.0980, WYE.354, GSK2126458, PF.05212384",0.482804102050026,0.189767482004916,FALSE +"HCC95","Pearson.est","NFkB pathway inhibitor",-0.20611,-0.5,0.983,832,1,"curcumin, parthenolide...., IKK.2.inhibitor.V, parthenolide, Ro.106.9920, EVP4593",0.00744648216786438,0,FALSE +"HCC95","Pearson.est","opioid receptor agonist",0.49728,1.33,0.166,103,0.373,"BW.180C, ADL5859",0.779891911959945,0.428291168191312,FALSE +"HCC95","Pearson.est","p38 MAPK inhibitor",-0.58875,-1.41,0.103,1240,0.381,"CMPD.1, SB.239063, talmapimod",0.987162775294828,0.419075024324381,FALSE +"HCC95","Pearson.est","PARP inhibitor",-0.36089,-0.872,0.62,907,0.908,"AZD2461, olaparib, PJ.34, niraparib, talazoparib",0.207608310501746,0.0419141514789149,FALSE +"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.2569,0.705,0.784,464,0.976,"KI.8751, orantinib, ponatinib, linifanib, dovitinib, CP.673451, telatinib, tandutinib, pazopanib, sunitinib, regorafenib, trapidil",0.105683937315562,0.0105501823333082,FALSE +"HCC95","Pearson.est","phosphatase inhibitor",0.45718,1.25,0.212,232,0.418,"bis.maltolato.oxovanadium.IV., GSK2830371, BVT.948, menadione, CID.5458317",0.673664139071249,0.378823718224965,FALSE +"HCC95","Pearson.est","phosphodiesterase inhibitor",0.37454,1.02,0.41,121,0.524,"anagrelide, GSK256066, enoximone",0.387216143280265,0.280668713016273,FALSE +"HCC95","Pearson.est","PI3K inhibitor",-0.49432,-1.19,0.253,1196,0.604,"TG.100713, PI.103, GDC.0980, PIK.75, GSK2126458, CH5132799, PF.05212384, alpelisib, taselisib",0.596879478824182,0.218963061378868,FALSE +"HCC95","Pearson.est","PLK inhibitor",-0.814,-1.97,0,1348,0.0307,"GW.843682X, HMN.214, BI.2536, volasertib, NMS.1286937",Inf,1.51286162452281,TRUE +"HCC95","Pearson.est","potassium channel blocker",0.3966,1.13,0.308,212,0.444,"meglitinide, ML133",0.511449283499556,0.35261702988538,FALSE +"HCC95","Pearson.est","PPAR receptor agonist",0.57999,1.62,0.0655,132,0.219,"fenofibrate, S26948, clofibrate",1.18375870000822,0.659555885159882,FALSE +"HCC95","Pearson.est","progesterone receptor agonist",0.54867,1.48,0.1,198,0.297,"norethindrone, nomegestrol.acetate, danazol, norethindrone.acetate, norgestrel",1,0.527243550682788,FALSE +"HCC95","Pearson.est","proteasome inhibitor",-0.44815,-1.07,0.368,1178,0.696,"carfilzomib",0.434152181326482,0.157390760389438,FALSE +"HCC95","Pearson.est","protein synthesis inhibitor",-0.51442,-1.22,0.22,1181,0.57,"thiostrepton, cycloheximide, harringtonine, anguidine, puromycin, homoharringtonine, tedizolid.phosphate, bruceantin",0.657577319177794,0.244125144327509,FALSE +"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.74314,-1.78,0.00855,1372,0.134,"BMS.599626, NVP.TAE226, CP.724714, AV.412",2.06803388527183,0.872895201635192,TRUE +"HCC95","Pearson.est","RAF inhibitor",0.44794,1.24,0.235,35,0.403,"dabrafenib, vemurafenib",0.628932137728264,0.39469495385889,FALSE +"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.32328,-0.791,0.708,1037,1,"cabozantinib, vandetanib",0.149966742310231,0,FALSE +"HCC95","Pearson.est","retinoid receptor agonist",-0.35302,-0.86,0.627,971,0.905,"adarotene, bexarotene, adapalene, CD.437",0.202732459169284,0.0433514207947967,FALSE +"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.30177,0.832,0.625,241,0.794,"pentostatin, hydroxyurea, fludarabine",0.204119982655925,0.100179497572904,FALSE +"HCC95","Pearson.est","serotonin receptor agonist",-0.65005,-1.57,0.0427,1238,0.27,"zolmitriptan, pardoprunox, aripiprazole",1.36957212497498,0.568636235841013,FALSE +"HCC95","Pearson.est","serotonin receptor antagonist",-0.31608,-0.766,0.763,1436,1,"aripiprazole",0.11747546204512,0,FALSE +"HCC95","Pearson.est","sodium channel blocker",-0.24539,-0.589,0.927,960,1,"benzethonium, triamterene, lappaconite, A.803467, brivaracetam",0.0329202658555029,0,FALSE +"HCC95","Pearson.est","src inhibitor",-0.71705,-1.73,0.0171,1369,0.157,"bosutinib, saracatinib, ZM.306416",1.76700388960785,0.804100347590766,TRUE +"HCC95","Pearson.est","sterol demethylase inhibitor",-0.23717,-0.582,0.918,342,1,"posaconazole, terconazole, ketoconazole, chlormidazole, sulconazole, lanoconazole",0.0371573187987575,0,FALSE +"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.60175,-1.47,0.0727,1083,0.386,"adaprev, SB.525334, D.4476, repsox",1.13846558914096,0.413412695328245,FALSE +"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.24124,-0.593,0.905,1268,1,"carmofur",0.0433514207947967,0,FALSE +"HCC95","Pearson.est","topoisomerase inhibitor",-0.43995,-1.07,0.395,798,0.696,"licochalcone.a, epirubicin, voreloxin, valrubicin, teniposide, idarubicin, daunorubicin, beta.lapachone, etoposide, amsacrine, TAS.103, irinotecan, mitoxantrone, genz.644282, amonafide, camptothecin, SN.38, exatecan.mesylate, dexrazoxane",0.40340290437354,0.157390760389438,FALSE +"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.6977,-1.68,0.0192,1139,0.198,"podophyllotoxin, combretastatin.A.4, flubendazole, indibulin, CYT.997, plinabulin, albendazole, fenbendazole, vincristine, mebendazole, dolastatin.10, fosbretabulin, taltobulin, nocodazole, ABT.751, vinorelbine, epothilone.b, parbendazole, docetaxel, paclitaxel",1.71669877129645,0.703334809738469,TRUE +"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.46455,-1.12,0.336,1372,0.646,"BMS.599626, NVP.TAE226, CP.724714, AV.412, tivantinib",0.473660722610156,0.189767482004916,FALSE +"HCC95","Pearson.est","VEGFR inhibitor",-0.47148,-1.15,0.289,933,0.662,"SAR131675, RAF265, TG.100572, golvatinib, foretinib, semaxanib, lenvatinib, cabozantinib, SU014813, vatalanib, cediranib, ENMD.2076, PD.173074, lucitanib, vandetanib, OSI.930, ZM.306416, AEE788, BMS.690514, XL.647",0.539102157243452,0.1791420105603,FALSE +"HCC95","Pearson.est","vitamin D receptor agonist",-0.58103,-1.44,0.102,846,0.353,"ercalcitriol, calcitriol, doxercalciferol, paricalcitol, tacalcitol, maxacalcitol",0.991399828238082,0.452225294612177,FALSE +"H1975","Pearson.est","EGFR inhibitor",0.75378,1.74,0.0062,170,0.215,"gefitinib, poziotinib, AZD8931, afatinib, AST.1306, neratinib, dacomitinib, erlotinib, pelitinib, XL.647, BIBU.1361, CUDC.101, lapatinib, osimertinib, BMS.690514, canertinib, ARRY.334543, vandetanib, WZ.4002, tucatinib, CNX.2006, PD.153035, BIBX.1382, AEE788, BMS.599626, icotinib",2.20760831050175,0.667561540084395,TRUE +"H1975","Pearson.est","Abl kinase inhibitor",0.44677,1.06,0.405,666,0.769,"ZM.306416, dasatinib, bosutinib, bafetinib, nilotinib, GZD824, imatinib, tozasertib",0.392544976785331,0.114073660198569,FALSE +"H1975","Pearson.est","acetylcholine receptor agonist",0.31852,0.738,0.792,634,0.941,"pilocarpine, tremorine, xanomeline, oxiracetam",0.101274818410506,0.0264103765727431,FALSE +"H1975","Pearson.est","acetylcholine receptor antagonist",-0.3726,-1.03,0.407,1262,0.869,"iododexetimide, methscopolamine",0.39040559077478,0.0609802235513335,FALSE +"H1975","Pearson.est","adenosine receptor antagonist",0.53704,1.27,0.188,399,0.549,"CGS.15943, PSB.1115, istradefylline, MRS.1220, SCH.58261, sulmazole",0.72584215073632,0.260427655549908,FALSE +"H1975","Pearson.est","adrenergic receptor agonist",-0.42733,-1.23,0.165,1186,0.749,"clenbuterol, midodrine, epinephrine, A61603, norepinephrine, lidamidine, xylazine",0.782516055786094,0.125518182300534,FALSE +"H1975","Pearson.est","adrenergic receptor antagonist",0.2973,0.689,0.845,567,0.94,"atenolol......, dihydroergocristine, dronedarone, oxprenolol, imiloxan, idazoxan, practolol, naftidrofuryl, prazosin",0.0731432910503077,0.0268721464003014,FALSE +"H1975","Pearson.est","AKT inhibitor",0.42379,0.995,0.475,438,0.76,"uprosertib, triciribine, palomid.529, GDC.0068, GSK2110183",0.323306390375133,0.119186407719209,FALSE +"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.41655,0.969,0.521,727,0.749,"AZD3463, alectinib, CEP.37440, SB.505124, NVP.TAE684, brigatinib, crizotinib, DMH1, lorlatinib",0.283162276700476,0.125518182300534,FALSE +"H1975","Pearson.est","androgen receptor antagonist",-0.32119,-0.878,0.551,1255,0.943,"enzalutamide, flutamide",0.258848401148215,0.0254883072626717,FALSE +"H1975","Pearson.est","antioxidant",-0.35198,-1.01,0.369,1332,0.853,"taurine, rutin",0.43297363384094,0.069050968832477,FALSE +"H1975","Pearson.est","AP inhibitor",-0.71291,-2.1,0,1426,0.081,"birinapant, LCL.161, GDC.0152",Inf,1.09151498112135,TRUE +"H1975","Pearson.est","ATPase inhibitor",-0.39797,-1.14,0.263,1224,0.724,"oligomycin.a, blebbistatin...., ouabain, digitoxigenin, digitoxin, omeprazole",0.580044251510242,0.140261433802853,FALSE +"H1975","Pearson.est","Aurora kinase inhibitor",0.42594,1,0.448,690,0.795,"ENMD.2076, PHA.680632, danusertib, CCT137690, hesperadin, barasertib.HQPA, CCT129202, GSK1070916, alisertib, AT.9283, CYC116, SNS.314, barasertib, tozasertib, MK.8745, PF.03814735",0.348721986001856,0.0996328713435297,FALSE +"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.42094,0.966,0.521,600,0.716,"azithromycin, azalomycin.b, tilmicosin, tedizolid, valnemulin, radezolid",0.283162276700476,0.145086977692144,FALSE +"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.30415,-0.851,0.632,1428,0.864,"sparfloxacin",0.199282921717615,0.0634862575211067,FALSE +"H1975","Pearson.est","BCL inhibitor",0.63111,1.45,0.0754,166,0.557,"obatoclax, gossypol, TW.37",1.12262865413023,0.254144804826271,FALSE +"H1975","Pearson.est","Bcr.Abl kinase inhibitor",0.43761,1.03,0.423,666,0.783,"dasatinib, bosutinib, bafetinib, nilotinib, GZD824, imatinib, tozasertib",0.373659632624958,0.106238237942057,FALSE +"H1975","Pearson.est","benzodiazepine receptor agonist",0.27345,0.626,0.912,377,0.944,"eprinomectin, zaleplon, ZK.93423, piperazine",0.0400051616715838,0.025028005701931,FALSE +"H1975","Pearson.est","bromodomain inhibitor",0.71298,1.67,0.0114,303,0.265,"JQ1...., I.BET151, bromosporine, OTX015, I.BET.762",1.94309514866353,0.576754126063192,FALSE +"H1975","Pearson.est","calcium channel blocker",0.47116,1.09,0.353,256,0.783,"tetrandrine, cinnarazine, mibefradil",0.452225294612177,0.106238237942057,FALSE +"H1975","Pearson.est","CC chemokine receptor antagonist",0.46866,1.09,0.358,648,0.783,"ZK811752, SB.225002, PF.04136309, navarixin",0.446116973356126,0.106238237942057,FALSE +"H1975","Pearson.est","CDK inhibitor",0.56804,1.3,0.155,556,0.509,"TG.02, P276.00, R547, JNJ.7706621, indisulam, ribociclib, aminopurvalanol.a, PHA.848125, AZD5438, palbociclib, alvocidib, indirubin, BMS.387032, arcyriaflavin.a, AT.7519, NU6027, dinaciclib, abemaciclib",0.809668301829709,0.293282217663241,FALSE +"H1975","Pearson.est","CHK inhibitor",0.30654,0.707,0.846,781,0.939,"AZD7762, SB.218078, LY2603618, CHIR.124, PF.477736",0.0726296369609765,0.0273344077338891,FALSE +"H1975","Pearson.est","cyclooxygenase inhibitor",-0.20462,-0.592,0.908,1236,1,"amfenac, acetylsalicylsalicylic.acid, naproxen, AM.404, suxibuzone, metoxibutropate",0.0419141514789149,0,FALSE +"H1975","Pearson.est","cytochrome P450 inhibitor",-0.28623,-0.809,0.674,1244,0.903,"eplerenone, clotrimazole",0.17134010346468,0.0443122496864942,FALSE +"H1975","Pearson.est","DNA alkylating agent",-0.19577,-0.535,0.979,1259,1,"carboplatin, dianhydrogalactitol, cisplatin",0.00921730819686218,0,FALSE +"H1975","Pearson.est","DNA inhibitor",0.37094,0.865,0.642,684,0.815,"mechlorethamine, oxaliplatin, bendamustine, carmustine, nimorazole, sangivamycin, valrubicin, melphalan, nithiamide, busulfan",0.192464971931147,0.0888423912600234,FALSE +"H1975","Pearson.est","DNA methyltransferase inhibitor",0.59498,1.38,0.0907,213,0.531,"fdcyd, azacitidine, disulfiram",1.0423927129399,0.274905478918531,FALSE +"H1975","Pearson.est","DNA polymerase inhibitor",0.44102,1.04,0.426,333,0.786,"idoxuridine, adefovir.dipivoxil, trifluridine, cidofovir",0.370590400897281,0.104577453960592,FALSE +"H1975","Pearson.est","DNA synthesis inhibitor",0.32948,0.764,0.781,366,0.949,"anisomycin, enocitabine, cyclocytidine, floxuridine, CB.10.277",0.1073489661227,0.0227337875727074,FALSE +"H1975","Pearson.est","dopamine receptor antagonist",0.42308,0.997,0.468,125,0.778,"mesoridazine, sertindole, domperidone",0.329754146925876,0.109020403010311,FALSE +"H1975","Pearson.est","estrogen receptor agonist",-0.31695,-0.896,0.538,1386,0.953,"estradiol, estradiol.cypionate",0.269217724333611,0.0209070993616736,FALSE +"H1975","Pearson.est","estrogen receptor antagonist",0.45424,1.07,0.385,289,0.774,"clomifene, raloxifene",0.414539270491499,0.111259039317107,FALSE +"H1975","Pearson.est","FGFR inhibitor",0.32505,0.755,0.801,335,0.939,"regorafenib, PD.173074, dovitinib",0.0963674839157623,0.0273344077338891,FALSE +"H1975","Pearson.est","FLT3 inhibitor",0.4293,0.993,0.483,666,0.742,"pacritinib, TG.02, ENMD.2076, dovitinib, TG.101348, gilteritinib, sorafenib, GTP.14564, quizartinib, lestaurtinib, sunitinib, tozasertib",0.316052869248488,0.129596094720973,FALSE +"H1975","Pearson.est","glucocorticoid receptor agonist",0.70775,1.63,0.0201,234,0.279,"hydrocortisone, ciclesonide, triamcinolone.acetonide, difluprednate, desonide, halobetasol.propionate, rimexolone, methylprednisolone, halcinonide, fluocinolone.acetonide, flumethasone.pivalate, prednisolone, clobetasol.propionate, deflazacort, prednisolone.acetate, fludroxycortide, triamcinolone",1.69680394257951,0.554395796726402,FALSE +"H1975","Pearson.est","glutamate receptor antagonist",0.25863,0.598,0.9,176,0.929,"CPP, CGP.37849",0.0457574905606751,0.0319842860063582,FALSE +"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.30987,-0.867,0.575,1192,0.873,"tideglusib, CHIR.99021, CHIR.98014",0.24033215531037,0.0589857562944303,FALSE +"H1975","Pearson.est","growth factor receptor inhibitor",0.58508,1.36,0.127,577,0.494,"danusertib, AZD3463, GSK1838705A, PHA.848125, GSK1904529A, lestaurtinib",0.896196279044043,0.306273051076353,FALSE +"H1975","Pearson.est","HCV inhibitor",0.3914,0.92,0.575,231,0.743,"embelin",0.24033215531037,0.129011186239425,FALSE +"H1975","Pearson.est","HDAC inhibitor",0.41467,0.967,0.508,456,0.732,"PCI.24781, givinostat, AR.42, trichostatin.a, M.344, RGFP966, R306465, dacinostat, belinostat, scriptaid, NSC.3852, vorinostat, SB.939",0.294136287716081,0.135488918941608,FALSE +"H1975","Pearson.est","histamine receptor antagonist",-0.20597,-0.569,0.939,1228,1,"zolantidine, tiotidine, cimetidine, lafutidine, chloropyramine",0.0273344077338891,0,FALSE +"H1975","Pearson.est","HMGCR inhibitor",-0.8444,-2.41,0,1281,0.0088,"atorvastatin, fluvastatin, pitavastatin, mevastatin",Inf,2.05551732784983,TRUE +"H1975","Pearson.est","HSP inhibitor",-0.52195,-1.49,0.0739,1091,0.501,"BIIB021, PU.H71, NMS.E973, ganetespib, NVP.AUY922, guanidine, KW.2478, alvespimycin",1.13135556160517,0.300162274132754,FALSE +"H1975","Pearson.est","JAK inhibitor",0.4837,1.12,0.329,360,0.807,"pacritinib, atiprimod, TG.02, AZ960, TG.101209, AZD1480, LY2784544, TG.101348",0.482804102050026,0.0931264652779296,FALSE +"H1975","Pearson.est","KIT inhibitor",0.26704,0.621,0.921,653,0.93,"OSI.930, regorafenib, dasatinib, sorafenib, masitinib, imatinib, sunitinib",0.0357403698031511,0.0315170514460649,FALSE +"H1975","Pearson.est","MDM inhibitor",0.75333,1.75,0.00493,222,0.393,"nutlin.3, idasanutlin, RITA, CGM097, serdemetan",2.30715308072277,0.405607449624573,FALSE +"H1975","Pearson.est","MEK inhibitor",0.66147,1.56,0.0418,107,0.38,"cobimetinib, AS.703026, trametinib, PD.0325901, AZD8330, selumetinib, TAK.733, Ro.4987655, MEK162",1.37882371822496,0.42021640338319,FALSE +"H1975","Pearson.est","MET inhibitor",-0.62097,-1.72,0.0591,1261,0.27,"PF.04217903, LY2801653",1.22841251911874,0.568636235841013,FALSE +"H1975","Pearson.est","microtubule inhibitor",-0.38804,-1.08,0.335,558,0.808,"podophyllotoxin, D.64131, secnidazole, triclabendazole, vinflunine, colchicine, cabazitaxel, estramustine.phosphate, vinblastine, cytochalasin.b",0.474955192963155,0.0925886392254138,FALSE +"H1975","Pearson.est","mTOR inhibitor",0.60923,1.42,0.1,364,0.519,"GSK2126458, WAY.600, WYE.354, AZD8055, XL388, WYE.125132, PP242, OSI.027, voxtalisib, LY303511, AZD2014, torin.2, PF.04691502, torin.1, GDC.0980, palomid.529",1,0.284832642151542,FALSE +"H1975","Pearson.est","NFkB pathway inhibitor",0.27781,0.648,0.912,363,0.942,"EVP4593, curcumin, betulinic.acid",0.0400051616715838,0.0259490972071227,FALSE +"H1975","Pearson.est","opioid receptor agonist",-0.40275,-1.14,0.28,1312,0.724,"ADL5859, BW.180C, spiradoline",0.552841968657781,0.140261433802853,FALSE +"H1975","Pearson.est","p38 MAPK inhibitor",0.58902,1.38,0.1,565,0.531,"SB.242235, CMPD.1, skepinone.l, talmapimod, SB.239063, VX.702",1,0.274905478918531,FALSE +"H1975","Pearson.est","PARP inhibitor",-0.32294,-0.908,0.522,1372,0.982,"olaparib, E7449",0.282329496997738,0.00788851221305034,FALSE +"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.27858,-0.792,0.762,1257,0.897,"motesanib, trapidil, nintedanib, SU014813, CP.673451, linifanib",0.1180450286604,0.0472075569559079,FALSE +"H1975","Pearson.est","phosphatase inhibitor",0.28426,0.654,0.866,637,0.956,"alexidine, mycophenolic.acid, mycophenolate.mofetil, sodium.stibogluconate, CID.5458317, GSK2830371",0.0624821079826534,0.0195421077238999,FALSE +"H1975","Pearson.est","phosphodiesterase inhibitor",-0.32359,-0.953,0.469,1177,0.932,"zardaverine, anagrelide, YM.976, GSK256066, enoximone",0.328827157284917,0.0305840876460186,FALSE +"H1975","Pearson.est","PI3K inhibitor",0.56867,1.34,0.132,526,0.508,"GSK2126458, taselisib, YM.201636, GDC.0941, alpelisib, buparlisib, voxtalisib, PI3K.IN.2, LY303511, CH5132799, PIK.75, PF.04691502, GDC.0980, CUDC.907, PI.828, AZD6482, TG.100713, BGT226, pilaralisib, PI.103, PKI.179",0.87942606879415,0.294136287716081,FALSE +"H1975","Pearson.est","PLK inhibitor",0.48608,1.15,0.293,189,0.796,"NMS.1286937",0.533132379645891,0.0990869322623309,FALSE +"H1975","Pearson.est","potassium channel blocker",-0.32401,-0.871,0.58,1375,0.911,"dofetilide",0.236572006437063,0.0404816230270017,FALSE +"H1975","Pearson.est","PPAR receptor agonist",-0.4364,-1.25,0.183,1220,0.808,"fenofibrate, S26948, clofibrate",0.737548910269571,0.0925886392254138,FALSE +"H1975","Pearson.est","progesterone receptor agonist",-0.43153,-1.22,0.19,1358,0.689,"norethindrone, dienogest, norgestrel",0.721246399047171,0.161780778092374,FALSE +"H1975","Pearson.est","proteasome inhibitor",-0.50534,-1.46,0.0545,1389,0.462,"ONX.0914, delanzomib",1.26360349772336,0.335358024443874,FALSE +"H1975","Pearson.est","protein synthesis inhibitor",0.41908,0.987,0.482,515,0.734,"brefeldin.a, cycloheximide, azomycin..2.nitroimidazole., homoharringtonine, clindamycin.phosphate, anguidine, bruceantin, emetine, thiostrepton",0.31695296176115,0.134303940083929,FALSE +"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.6247,1.49,0.0605,243,0.507,"NVP.TAE226, AV.412, BMS.599626, tyrphostin.A9, CP.724714",1.21824462534753,0.294992040666664,FALSE +"H1975","Pearson.est","RAF inhibitor",0.56058,1.32,0.148,223,0.523,"AZ.628, SB.590885, CEP.32496, regorafenib, LGX818",0.829738284605043,0.281498311132726,FALSE +"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.5478,1.3,0.159,653,0.509,"vandetanib, regorafenib, sorafenib, apatinib, sunitinib",0.798602875679548,0.293282217663241,FALSE +"H1975","Pearson.est","retinoid receptor agonist",0.45567,1.08,0.351,313,0.779,"CD.437, tamibarotene, adarotene",0.454692883534176,0.108462542327436,FALSE +"H1975","Pearson.est","ribonucleotide reductase inhibitor",0.30906,0.716,0.829,660,0.948,"cytarabine, fludarabine.phosphate, LY2334737, triapine, clofarabine",0.0814454694497265,0.0231916626619338,FALSE +"H1975","Pearson.est","serotonin receptor agonist",-0.67324,-2.01,0.0193,1288,0.0998,"SR.57227A, pardoprunox, aripiprazole",1.71444269099223,1.00086945871263,TRUE +"H1975","Pearson.est","serotonin receptor antagonist",0.39151,0.928,0.57,267,0.747,"SB.228357, SB.200646, sertindole, SB.216641, pirenperone",0.244125144327509,0.126679398184601,FALSE +"H1975","Pearson.est","sodium channel blocker",-0.22201,-0.619,0.917,1248,1,"lappaconite, oxcarbazepine, brivaracetam, cibenzoline",0.0376306643299789,0,FALSE +"H1975","Pearson.est","src inhibitor",0.47974,1.14,0.313,356,0.787,"ZM.306416, saracatinib, dasatinib, bosutinib",0.504455662453552,0.104025267640935,FALSE +"H1975","Pearson.est","sterol demethylase inhibitor",0.43812,1.02,0.438,445,0.778,"lanoconazole, posaconazole, sulconazole",0.3585258894959,0.109020403010311,FALSE +"H1975","Pearson.est","TGF beta receptor inhibitor",0.49183,1.15,0.316,461,0.796,"D.4476, SB.525334, SB.431542, repsox",0.500312917381596,0.0990869322623309,FALSE +"H1975","Pearson.est","thymidylate synthase inhibitor",0.595,1.36,0.121,326,0.494,"carmofur, raltitrexed, trifluridine",0.91721462968355,0.306273051076353,FALSE +"H1975","Pearson.est","topoisomerase inhibitor",-0.17217,-0.481,0.985,245,0.989,"amsacrine, idarubicin, SN.38, exatecan.mesylate, voreloxin, valrubicin, licochalcone.a, TAS.103, camptothecin, dexrazoxane, teniposide, doxorubicin, nemorubicin, beta.lapachone, topotecan, fleroxacin, mitoxantrone, genz.644282, rubitecan, daunorubicin, amonafide, irinotecan, etoposide, epirubicin, etoposide.phosphate",0.00656376950238827,0.0048037084028206,FALSE +"H1975","Pearson.est","tubulin polymerization inhibitor",-0.20114,-0.559,0.958,1327,1,"docetaxel, vinblastine, paclitaxel, epothilone.d, BNC105",0.0186344909214556,0,FALSE +"H1975","Pearson.est","tyrosine kinase inhibitor",0.47713,1.1,0.342,441,0.824,"NVP.TAE226, vandetanib, AV.412, hypericin, BMS.599626, tyrphostin.A9, regorafenib, CP.724714, dasatinib, aminopurvalanol.a, tivantinib, sorafenib, bafetinib",0.465973893943865,0.0840727883028842,FALSE +"H1975","Pearson.est","VEGFR inhibitor",0.40466,0.957,0.541,335,0.714,"XL.647, BMS.690514, ZM.306416, OSI.930, vandetanib, ENMD.2076, AEE788, regorafenib, golvatinib, PD.173074, dovitinib",0.266802734893431,0.146301788223826,FALSE +"H1975","Pearson.est","vitamin D receptor agonist",0.6109,1.43,0.084,459,0.549,"tacalcitol, alfacalcidol, ercalcitriol, calcitriol, maxacalcitol",1.07572071393812,0.260427655549908,FALSE +"H1648","Pearson.est","EGFR inhibitor",-0.8675,-2.36,0.00325,1404,0.00209,"icotinib, BIBU.1361, PD.153035, AST.1306, TAK.285, AEE788, rociletinib, vandetanib, WZ8040, CP.724714, BMS.599626, BIBX.1382, pelitinib, GW.583340, ARRY.334543, PD.168393, erlotinib, gefitinib, osimertinib, afatinib, BMS.690514, lapatinib, dacomitinib, XL.647, canertinib, tucatinib, neratinib, poziotinib, AZD8931",2.48811663902113,2.67985371388895,TRUE +"H1648","Pearson.est","Abl kinase inhibitor",0.46859,1.11,0.335,264,0.59,"GZD824, tozasertib, ponatinib, nilotinib, bafetinib, KW.2449, flumatinib",0.474955192963155,0.229147988357856,FALSE +"H1648","Pearson.est","acetylcholine receptor agonist",0.52918,1.26,0.182,36,0.488,"oxiracetam",0.739928612014925,0.311580177997289,FALSE +"H1648","Pearson.est","acetylcholine receptor antagonist",0.50363,1.2,0.267,520,0.528,"iododexetimide, diphemanil, darifenacin",0.573488738635425,0.277366077466188,FALSE +"H1648","Pearson.est","adenosine receptor antagonist",-0.48527,-1.27,0.196,1291,0.559,"theophylline, MRS.1220, CGS.15943",0.707743928643524,0.252588192113577,FALSE +"H1648","Pearson.est","adrenergic receptor agonist",0.26433,0.634,0.903,794,0.985,"buphenine, isoetharine, oxymetazoline, norepinephrine, metaraminol, ritodrine, clenbuterol, lidamidine, isoxsuprine, midodrine",0.0443122496864942,0.00656376950238827,FALSE +"H1648","Pearson.est","adrenergic receptor antagonist",0.37103,0.879,0.615,452,0.785,"oxprenolol, metoprolol, carvedilol, naftidrofuryl, levobunolol, atipamezole, idazoxan",0.211124884224583,0.105130343254747,FALSE +"H1648","Pearson.est","AKT inhibitor",-0.62829,-1.65,0.0645,1247,0.323,"A.674563, GSK2110183, CCT128930, triciribine, uprosertib, GDC.0068",1.19044028536473,0.490797477668897,FALSE +"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27322,-0.707,0.798,1360,0.955,"GW.788388, brigatinib",0.0979971086492706,0.0199966284162537,FALSE +"H1648","Pearson.est","androgen receptor antagonist",0.51595,1.23,0.217,268,0.488,"nilutamide, bicalutamide",0.66354026615147,0.311580177997289,FALSE +"H1648","Pearson.est","antioxidant",0.63141,1.51,0.0641,258,0.451,"trolox, benfotiamine, chlorogenic.acid",1.19314197048118,0.345823458122039,FALSE +"H1648","Pearson.est","AP inhibitor",0.45152,1.07,0.374,239,0.593,"idronoxil, embelin",0.42712839779952,0.226945306635737,FALSE +"H1648","Pearson.est","ATPase inhibitor",0.30413,0.731,0.807,615,0.933,"digoxin, blebbistatin...., digitoxin, ouabain, thonzonium, evodiamine, digitoxigenin",0.0931264652779296,0.0301183562535,FALSE +"H1648","Pearson.est","Aurora kinase inhibitor",0.42414,1.02,0.446,412,0.629,"barasertib, tozasertib, AT.9283, AMG900, SNS.314, KW.2449, PF.03814735, hesperadin, barasertib.HQPA, ENMD.2076, alisertib",0.350665141287858,0.201349354554731,FALSE +"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.36159,-0.954,0.46,1248,0.974,"josamycin, tedizolid, azithromycin",0.337242168318426,0.0114410431213845,FALSE +"H1648","Pearson.est","bacterial DNA gyrase inhibitor",0.21439,0.521,0.98,633,0.987,"novobiocin, sparfloxacin, norfloxacin, sarafloxacin",0.00877392430750515,0.00568284733036327,FALSE +"H1648","Pearson.est","BCL inhibitor",0.48386,1.17,0.263,553,0.513,"venetoclax, TW.37, oridonin, gossypol, ABT.737",0.580044251510242,0.289882634888184,FALSE +"H1648","Pearson.est","Bcr.Abl kinase inhibitor",0.55817,1.34,0.137,264,0.608,"GZD824, tozasertib, ponatinib, nilotinib, bafetinib, flumatinib",0.863279432843593,0.216096420727265,FALSE +"H1648","Pearson.est","benzodiazepine receptor agonist",0.31877,0.765,0.761,656,0.926,"temazepam, indiplon, ZK.93423, eprinomectin, zaleplon, piperazine, gamma.aminobutyric.acid",0.118615343229427,0.0333890133180656,FALSE +"H1648","Pearson.est","bromodomain inhibitor",-0.27947,-0.74,0.757,403,0.948,"bromosporine, PFI.1, I.BET.762, I.BET151, JQ1...., OTX015",0.120904120499927,0.0231916626619338,FALSE +"H1648","Pearson.est","calcium channel blocker",-0.28169,-0.762,0.782,1325,1,"fendiline, SKF.96365",0.106793246940152,0,FALSE +"H1648","Pearson.est","CC chemokine receptor antagonist",0.68501,1.63,0.0204,357,0.485,"UNBS.5162, navarixin, PF.04136309, SB.225002, MK.0812",1.6903698325741,0.314258261397736,FALSE +"H1648","Pearson.est","CDK inhibitor",-0.25131,-0.64,0.893,1371,1,"BMS.387032, indirubin, AT.7519",0.0491485411114536,0,FALSE +"H1648","Pearson.est","CHK inhibitor",-0.47606,-1.27,0.197,686,0.559,"SB.218078, PF.477736, SCH.900776, AZD7762, LY2606368, CHIR.124, LY2603618",0.705533773838407,0.252588192113577,FALSE +"H1648","Pearson.est","cyclooxygenase inhibitor",-0.20309,-0.541,0.961,1336,0.962,"tryptanthrin, ramifenazone, FK.3311, amfenac",0.0172766123314547,0.0168249279621871,FALSE +"H1648","Pearson.est","cytochrome P450 inhibitor",0.60897,1.45,0.0874,370,0.495,"metyrapone, morin, cobicistat, itraconazole",1.0584885673656,0.305394801066431,FALSE +"H1648","Pearson.est","DNA alkylating agent",0.37005,0.89,0.593,135,0.784,"melphalan, carboplatin, carmustine",0.226945306635737,0.105683937315562,FALSE +"H1648","Pearson.est","DNA inhibitor",0.41542,0.991,0.478,417,0.663,"melphalan, carboplatin, chlorambucil, carmustine, pibenzimol, bendamustine, valrubicin, teroxirone",0.320572103387881,0.178486471595227,FALSE +"H1648","Pearson.est","DNA methyltransferase inhibitor",-0.50353,-1.3,0.161,1380,0.655,"decitabine, azacitidine, SGI.1027",0.79317412396815,0.183758700008217,FALSE +"H1648","Pearson.est","DNA polymerase inhibitor",0.26677,0.645,0.884,495,0.993,"foscarnet, idoxuridine, trifluridine",0.0535477349869269,0.00305075150461883,FALSE +"H1648","Pearson.est","DNA synthesis inhibitor",0.49135,1.19,0.258,385,0.511,"nelarabine, azodicarbonamide, anisomycin, floxuridine, artesunate, artemisinin, CB.10.277",0.58838029403677,0.291579099865287,FALSE +"H1648","Pearson.est","dopamine receptor antagonist",0.27846,0.661,0.852,193,0.997,"amisulpride, raclopride, paliperidone",0.0695604052332999,0.00130484168834428,FALSE +"H1648","Pearson.est","estrogen receptor agonist",-0.27905,-0.746,0.786,1312,0.984,"erteberel, levonorgestrel",0.104577453960592,0.00700490156865849,FALSE +"H1648","Pearson.est","estrogen receptor antagonist",0.45424,1.1,0.367,324,0.574,"fulvestrant, danazol, toremifene",0.435333935747911,0.241088107602027,FALSE +"H1648","Pearson.est","FGFR inhibitor",0.64732,1.54,0.0435,236,0.441,"erdafitinib, dovitinib, regorafenib, nintedanib, MK.2461, orantinib",1.36151074304536,0.355561410532161,FALSE +"H1648","Pearson.est","FLT3 inhibitor",0.62797,1.48,0.0585,294,0.47,"dovitinib, TG.101348, tozasertib, midostaurin, ponatinib, quizartinib, sunitinib, KW.2449, lestaurtinib, gilteritinib",1.23284413391782,0.327902142064283,FALSE +"H1648","Pearson.est","glucocorticoid receptor agonist",-0.54631,-1.45,0.0886,1137,0.466,"difluprednate, dexamethasone.acetate, halobetasol.propionate, halcinonide, desonide, flumethasone.pivalate, methylprednisolone, beclomethasone.dipropionate, ciclesonide, fluorometholone, fludroxycortide, clobetasol.propionate, betamethasone, flumethasone, triamcinolone.acetonide",1.05256627811295,0.33161408331,FALSE +"H1648","Pearson.est","glutamate receptor antagonist",0.15631,0.369,1,741,0.999,"MTPG, ACDPP, IEM1754, diazooxonorleucine, felbamate, CPP, SIB.1757",0,0.000434511774017692,FALSE +"H1648","Pearson.est","glycogen synthase kinase inhibitor",0.31993,0.767,0.744,459,0.943,"tideglusib, CHIR.99021, CHIR.98014, GSK.3.inhibitor.IX",0.128427064454121,0.0254883072626717,FALSE +"H1648","Pearson.est","growth factor receptor inhibitor",0.37789,0.9,0.588,596,0.787,"lestaurtinib, danusertib, PHA.848125, GSK1838705A, AZD3463",0.230622673923862,0.104025267640935,FALSE +"H1648","Pearson.est","HCV inhibitor",0.49252,1.18,0.272,384,0.513,"narlaprevir, embelin, mericitabine",0.565431095965801,0.289882634888184,FALSE +"H1648","Pearson.est","HDAC inhibitor",0.30553,0.736,0.78,740,0.946,"entinostat, resminostat, dacinostat, trichostatin.a, RG2833, R306465, nexturastat.a, belinostat, M.344, vorinostat, ACY.1215, chidamide, scriptaid, NSC.3852, panobinostat",0.10790539730952,0.0241088635982073,FALSE +"H1648","Pearson.est","histamine receptor antagonist",0.24554,0.588,0.939,491,0.985,"pheniramine, famotidine, cimetidine, tiotidine, lafutidine, ICI.162846, epinastine, nizatidine",0.0273344077338891,0.00656376950238827,FALSE +"H1648","Pearson.est","HMGCR inhibitor",0.88532,2.13,0.00145,6,0.000981,"mevastatin, pitavastatin, fluvastatin, atorvastatin",2.83863199776503,3.00833099262005,TRUE +"H1648","Pearson.est","HSP inhibitor",-0.32629,-0.849,0.641,1307,0.948,"VER.49009, tanespimycin, alvespimycin, KW.2478",0.193141970481183,0.0231916626619338,FALSE +"H1648","Pearson.est","JAK inhibitor",0.45604,1.09,0.369,263,0.575,"TG.101348, tozasertib, AT.9283, TG.101209, AZ960, lestaurtinib",0.43297363384094,0.24033215531037,FALSE +"H1648","Pearson.est","KIT inhibitor",0.50095,1.19,0.279,529,0.511,"KI.8751, midostaurin, pazopanib, regorafenib, sunitinib, masitinib, motesanib, telatinib, sorafenib, lenvatinib",0.554395796726402,0.291579099865287,FALSE +"H1648","Pearson.est","MDM inhibitor",0.87828,2.14,0,80,0.00196,"idasanutlin, AMG.232, nutlin.3, CGM097, serdemetan",Inf,2.70774392864352,TRUE +"H1648","Pearson.est","MEK inhibitor",-0.33511,-0.894,0.579,1141,0.912,"PD.198306, PD.318088, PD.0325901, PD.184352, AZD8330, Ro.4987655, selumetinib, AS.703026, trametinib",0.237321436272564,0.0400051616715838,FALSE +"H1648","Pearson.est","MET inhibitor",-0.35399,-0.934,0.517,1422,0.947,"INC.280",0.286509456906058,0.0236500209967266,FALSE +"H1648","Pearson.est","microtubule inhibitor",0.54939,1.3,0.158,133,0.498,"vinblastine, secnidazole, vinflunine",0.801342913045577,0.302770657240282,FALSE +"H1648","Pearson.est","mTOR inhibitor",0.22145,0.537,0.964,669,0.998,"torin.1, ku.0063794, deforolimus, LY303511, WAY.600, SB.2343, LY3023414, sirolimus, NVP.BEZ235, PKI.179, XL388, temsirolimus, AZD8055, AZD2014",0.0159229660971692,0.000869458712628891,FALSE +"H1648","Pearson.est","NFkB pathway inhibitor",-0.2305,-0.618,0.895,331,0.98,"BAY.11.7082, bortezomib, betulinic.acid, BAY.11.7085, curcumin, parthenolide...., parthenolide, bindarit, EVP4593, tyloxapol, Ro.106.9920, IKK.2.inhibitor.V",0.048176964684088,0.00877392430750515,FALSE +"H1648","Pearson.est","opioid receptor agonist",0.59792,1.44,0.0795,518,0.473,"cebranopadol, trimebutine, BW.180C, spiradoline, salvinorin.a",1.09963287134353,0.325138859262188,FALSE +"H1648","Pearson.est","p38 MAPK inhibitor",-0.42596,-1.09,0.361,1323,0.879,"SB.239063, talmapimod",0.442492798094342,0.0560111249262281,FALSE +"H1648","Pearson.est","PARP inhibitor",0.55286,1.33,0.154,433,0.591,"talazoparib, AG.14361, niraparib, PJ.34",0.812479279163537,0.228412519118745,FALSE +"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.54535,1.31,0.153,529,0.504,"KI.8751, dovitinib, axitinib, ponatinib, pazopanib, regorafenib, sunitinib, nintedanib, orantinib, masitinib, CP.673451, SU014813, crenolanib, trapidil, motesanib, telatinib, sorafenib, lenvatinib",0.815308569182401,0.297569463554475,FALSE +"H1648","Pearson.est","phosphatase inhibitor",0.6766,1.6,0.0322,61,0.455,"bis.maltolato.oxovanadium.IV., GSK2830371, BVT.948, sodium.stibogluconate",1.49214412830417,0.341988603342888,FALSE +"H1648","Pearson.est","phosphodiesterase inhibitor",0.53453,1.26,0.183,33,0.488,"anagrelide, GSK256066",0.737548910269571,0.311580177997289,FALSE +"H1648","Pearson.est","PI3K inhibitor",-0.34815,-0.928,0.521,1265,0.896,"TG.100713, PF.05212384, GDC.0980, GSK2126458, CH5132799, alpelisib, taselisib",0.283162276700476,0.0476919903378748,FALSE +"H1648","Pearson.est","PLK inhibitor",0.57843,1.37,0.121,379,0.622,"rigosertib, volasertib, GSK461364",0.91721462968355,0.206209615309181,FALSE +"H1648","Pearson.est","potassium channel blocker",0.52543,1.25,0.184,558,0.488,"meglitinide, dofetilide, mepivacaine, oleoylethanolamide",0.735182176990464,0.311580177997289,FALSE +"H1648","Pearson.est","PPAR receptor agonist",0.45597,1.1,0.359,698,0.574,"clofibrate, GW.501516, fenofibrate, oleoylethanolamide, S26948, ciprofibrate",0.444905551421681,0.241088107602027,FALSE +"H1648","Pearson.est","progesterone receptor agonist",0.55625,1.32,0.155,153,0.577,"norethindrone, danazol, tanaproget",0.809668301829709,0.238824186844269,FALSE +"H1648","Pearson.est","proteasome inhibitor",0.54645,1.31,0.153,536,0.504,"ixazomib, MG.132, delanzomib, oprozomib, bortezomib, ONX.0914",0.815308569182401,0.297569463554475,FALSE +"H1648","Pearson.est","protein synthesis inhibitor",0.43581,1.06,0.393,336,0.593,"brefeldin.a, mercaptopurine, cycloheximide, homoharringtonine, harringtonine, methacycline, anguidine",0.405607449624573,0.226945306635737,FALSE +"H1648","Pearson.est","protein tyrosine kinase inhibitor",-0.73932,-1.96,0.00687,1418,0.0805,"CP.724714, BMS.599626, AV.412",2.16304326294045,1.09420411963213,TRUE +"H1648","Pearson.est","RAF inhibitor",0.54133,1.31,0.156,640,0.504,"dabrafenib, vemurafenib, regorafenib, TAK.632, LGX818, GDC.0879, CEP.32496, sorafenib, RAF265, SB.590885, AZ.628",0.806875401645538,0.297569463554475,FALSE +"H1648","Pearson.est","RET tyrosine kinase inhibitor",0.38665,0.929,0.564,151,0.754,"regorafenib, sunitinib",0.248720896016658,0.122628654130226,FALSE +"H1648","Pearson.est","retinoid receptor agonist",0.25275,0.6,0.912,137,0.994,"fenretinide",0.0400051616715838,0.00261361560268669,FALSE +"H1648","Pearson.est","ribonucleotide reductase inhibitor",0.66371,1.57,0.0418,443,0.437,"cladribine, pentostatin, triapine, clofarabine, fludarabine, fludarabine.phosphate, hydroxyurea, LY2334737",1.37882371822496,0.359518563029578,FALSE +"H1648","Pearson.est","serotonin receptor agonist",0.56884,1.35,0.129,527,0.627,"NAN.190, aripiprazole, SR.57227A, ipsapirone",0.889410289700751,0.202732459169284,FALSE +"H1648","Pearson.est","serotonin receptor antagonist",0.51875,1.24,0.221,262,0.487,"lerisetron, SB.200646, aripiprazole, paliperidone, pirenperone",0.655607726314889,0.312471038785366,FALSE +"H1648","Pearson.est","sodium channel blocker",-0.20939,-0.546,0.969,1286,0.997,"A.803467, lappaconite, brivaracetam",0.0136762229492347,0.00130484168834428,FALSE +"H1648","Pearson.est","src inhibitor",-0.58654,-1.55,0.0629,1332,0.389,"dasatinib, bosutinib, ZM.306416, saracatinib",1.20134935455473,0.410050398674292,FALSE +"H1648","Pearson.est","sterol demethylase inhibitor",0.5386,1.28,0.181,347,0.49,"ketoconazole, posaconazole, chlormidazole, lanoconazole",0.742321425130815,0.309803919971486,FALSE +"H1648","Pearson.est","TGF beta receptor inhibitor",-0.38776,-1.06,0.377,1402,0.866,"repsox",0.423658649794207,0.0624821079826534,FALSE +"H1648","Pearson.est","thymidylate synthase inhibitor",0.42473,1.02,0.444,523,0.629,"ftorafur, trifluridine, doxifluridine, raltitrexed",0.35261702988538,0.201349354554731,FALSE +"H1648","Pearson.est","topoisomerase inhibitor",0.53522,1.28,0.167,415,0.49,"nemorubicin, etoposide.phosphate, topotecan, teniposide, daunorubicin, voreloxin, doxorubicin, amsacrine, epirubicin, rubitecan, idarubicin, TAS.103, valrubicin, amonafide, etoposide",0.777283528852417,0.309803919971486,FALSE +"H1648","Pearson.est","tubulin polymerization inhibitor",0.492,1.16,0.29,511,0.515,"verubulin, vinblastine, BNC105, taltobulin, combretastatin.A.4, vindesine, CYT.997, vincristine, plinabulin, KX2.391, fosbretabulin, vinorelbine, podophyllotoxin, dolastatin.10",0.537602002101044,0.288192770958809,FALSE +"H1648","Pearson.est","tyrosine kinase inhibitor",-0.36687,-0.965,0.48,1415,1,"vandetanib, CP.724714, BMS.599626, AV.412",0.318758762624413,0,FALSE +"H1648","Pearson.est","VEGFR inhibitor",-0.30751,-0.794,0.652,1411,1,"AEE788, vandetanib, ZM.306416, BMS.690514, XL.647",0.18575240426808,0,FALSE +"H1648","Pearson.est","vitamin D receptor agonist",-0.85631,-2.28,0,1299,0.00627,"ercalcitriol, paricalcitol, tacalcitol, calcitriol, maxacalcitol",Inf,2.20273245916928,TRUE +"H2126","Pearson.est","EGFR inhibitor",-0.83003,-2.18,0,1371,0.0166,"rociletinib, AST.1306, vandetanib, BIBU.1361, afatinib, WZ8040, PD.153035, TAK.285, erlotinib, AEE788, CUDC.101, dacomitinib, ARRY.334543, BMS.599626, BIBX.1382, gefitinib, canertinib, osimertinib, CP.724714, GW.583340, XL.647, poziotinib, PD.168393, BMS.690514, lapatinib, neratinib, AZD8931, tucatinib",Inf,1.77989191195995,TRUE +"H2126","Pearson.est","Abl kinase inhibitor",0.48701,1.19,0.256,94,0.593,"ponatinib, GZD824, tozasertib, KW.2449",0.59176003468815,0.226945306635737,FALSE +"H2126","Pearson.est","acetylcholine receptor agonist",0.31132,0.769,0.766,79,0.882,"oxiracetam",0.115771230367396,0.0545314148681803,FALSE +"H2126","Pearson.est","acetylcholine receptor antagonist",0.23508,0.583,0.946,216,0.986,"iododexetimide",0.0241088635982073,0.0061230850587888,FALSE +"H2126","Pearson.est","adenosine receptor antagonist",-0.74087,-1.96,0.0119,1390,0.0524,"SCH.58261, MRS.1220, CGS.15943",1.92445303860747,1.28066871301627,TRUE +"H2126","Pearson.est","adrenergic receptor agonist",0.28732,0.682,0.848,538,0.943,"midodrine, lidamidine, buphenine, clenbuterol, oxymetazoline, terbutaline, ritodrine",0.0716041477432862,0.0254883072626717,FALSE +"H2126","Pearson.est","adrenergic receptor antagonist",0.22516,0.549,0.946,499,0.991,"oxprenolol, idazoxan, carvedilol, metoprolol, levobunolol, naftidrofuryl, atipamezole",0.0241088635982073,0.00392634551472468,FALSE +"H2126","Pearson.est","AKT inhibitor",-0.72093,-1.91,0.00893,1295,0.0523,"triciribine, A.674563, CCT128930, uprosertib, GSK2110183, GDC.0068",2.04914854111145,1.28149831113273,TRUE +"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.41451,0.994,0.475,346,0.784,"lorlatinib, DMH1, AZD3463, alectinib",0.323306390375133,0.105683937315562,FALSE +"H2126","Pearson.est","androgen receptor antagonist",0.37416,0.909,0.565,505,0.86,"nilutamide, bicalutamide, cyproterone.acetate",0.247951552180562,0.0655015487564323,FALSE +"H2126","Pearson.est","antioxidant",0.50686,1.23,0.224,594,0.584,"mesna, trolox, benfotiamine, chlorogenic.acid",0.649751981665837,0.233587152887601,FALSE +"H2126","Pearson.est","AP inhibitor",0.33481,0.811,0.692,593,0.89,"idronoxil, embelin, GDC.0152, LCL.161, birinapant",0.159893905543242,0.0506099933550872,FALSE +"H2126","Pearson.est","ATPase inhibitor",0.41785,1.01,0.454,310,0.775,"ouabain, blebbistatin...., digitoxin, digoxin, thonzonium, digitoxigenin",0.342944147142896,0.11069829749369,FALSE +"H2126","Pearson.est","Aurora kinase inhibitor",0.48142,1.14,0.331,348,0.625,"barasertib, tozasertib, KW.2449, AT.9283, AMG900, SNS.314, PF.03814735, hesperadin, GSK1070916, barasertib.HQPA, alisertib, ENMD.2076",0.480172006224281,0.204119982655925,FALSE +"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.25396,0.611,0.911,153,0.981,"valnemulin",0.0404816230270017,0.0083309926200515,FALSE +"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.38054,0.931,0.525,136,0.862,"sparfloxacin, novobiocin",0.279840696594043,0.0644927341752872,FALSE +"H2126","Pearson.est","BCL inhibitor",0.39995,0.984,0.492,484,0.78,"venetoclax, obatoclax, TW.37, ABT.737, gossypol",0.30803489723264,0.10790539730952,FALSE +"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.54689,1.32,0.162,397,0.602,"ponatinib, GZD824, tozasertib, nilotinib, flumatinib, bafetinib",0.790484985457369,0.220403508742175,FALSE +"H2126","Pearson.est","benzodiazepine receptor agonist",0.21028,0.513,0.972,742,0.991,"temazepam, piperazine, indiplon, eprinomectin, zaleplon, gamma.aminobutyric.acid, ivermectin, ZK.93423, CGS.20625",0.0123337350737254,0.00392634551472468,FALSE +"H2126","Pearson.est","bromodomain inhibitor",-0.8054,-2.13,0,1285,0.0177,"I.BET151, OTX015, JQ1....",Inf,1.75202673363819,TRUE +"H2126","Pearson.est","calcium channel blocker",-0.36069,-0.952,0.451,1224,0.774,"SKF.96365, SR.33805, fendiline",0.345823458122039,0.111259039317107,FALSE +"H2126","Pearson.est","CC chemokine receptor antagonist",0.68157,1.68,0.0214,377,0.319,"UNBS.5162, SB.225002, navarixin, PF.04136309, MK.0812",1.66958622665081,0.496209316942819,FALSE +"H2126","Pearson.est","CDK inhibitor",-0.24804,-0.666,0.852,1427,0.938,"arcyriaflavin.a, indirubin",0.0695604052332999,0.0277971616209356,FALSE +"H2126","Pearson.est","CHK inhibitor",0.4989,1.24,0.215,466,0.617,"SCH.900776, LY2606368, PF.477736, SB.218078",0.667561540084395,0.209714835966758,FALSE +"H2126","Pearson.est","cyclooxygenase inhibitor",-0.17321,-0.466,0.997,1067,0.99,"metoxibutropate, meloxicam, sulfasalazine, AM.404, ramifenazone, aspirin, FK.3311, amfenac, tryptanthrin",0.00130484168834428,0.00436480540245009,FALSE +"H2126","Pearson.est","cytochrome P450 inhibitor",0.6974,1.72,0.0139,114,0.444,"metyrapone, itraconazole, morin",1.8569851997459,0.35261702988538,FALSE +"H2126","Pearson.est","DNA alkylating agent",0.50166,1.23,0.256,328,0.584,"melphalan, carmustine, carboplatin, temozolomide, estramustine, streptozotocin",0.59176003468815,0.233587152887601,FALSE +"H2126","Pearson.est","DNA inhibitor",0.3449,0.831,0.68,257,0.877,"melphalan, carmustine, chlorambucil, carboplatin",0.167491087293764,0.0570004066339595,FALSE +"H2126","Pearson.est","DNA methyltransferase inhibitor",-0.31449,-0.823,0.644,1256,0.822,"azacitidine, SGI.1027",0.191114132640188,0.0851281824599496,FALSE +"H2126","Pearson.est","DNA polymerase inhibitor",0.4831,1.17,0.277,497,0.586,"trifluridine, idoxuridine, adefovir.dipivoxil, foscarnet",0.557520230935551,0.232102383981909,FALSE +"H2126","Pearson.est","DNA synthesis inhibitor",0.41355,1.01,0.439,644,0.775,"nelarabine, anisomycin, floxuridine, cyclocytidine, artesunate, azodicarbonamide, artemisinin, capecitabine, CB.10.277",0.357535479757879,0.11069829749369,FALSE +"H2126","Pearson.est","dopamine receptor antagonist",0.31935,0.793,0.741,160,0.882,"raclopride, paliperidone, amisulpride, isofloxythepin",0.130181792020672,0.0545314148681803,FALSE +"H2126","Pearson.est","estrogen receptor agonist",0.2636,0.634,0.888,524,0.977,"estrone, PPT, estradiol",0.051587034221399,0.0101054362812269,FALSE +"H2126","Pearson.est","estrogen receptor antagonist",0.34524,0.842,0.642,476,0.879,"toremifene, fulvestrant, raloxifene, danazol",0.192464971931147,0.0560111249262281,FALSE +"H2126","Pearson.est","FGFR inhibitor",0.53259,1.28,0.196,247,0.59,"erdafitinib, dovitinib, MK.2461, regorafenib",0.707743928643524,0.229147988357856,FALSE +"H2126","Pearson.est","FLT3 inhibitor",0.57093,1.43,0.114,348,0.491,"ponatinib, gilteritinib, tozasertib, dovitinib, KW.2449, lestaurtinib, sunitinib, midostaurin, tyrphostin.AG.1296, quizartinib, ENMD.2076",0.943095148663527,0.308918507877032,FALSE +"H2126","Pearson.est","glucocorticoid receptor agonist",-0.30724,-0.808,0.679,1050,0.806,"deflazacort, rimexolone, halobetasol.propionate, betamethasone, beclomethasone.dipropionate, difluprednate, fludroxycortide, halcinonide, flumethasone, methylprednisolone, triamcinolone.acetonide, clobetasol.propionate",0.168130225719498,0.0936649581949093,FALSE +"H2126","Pearson.est","glutamate receptor antagonist",-0.36744,-0.977,0.476,1160,0.779,"CPP, ACDPP, latrepirdine, LY456236, tiletamine, CGP.37849",0.322393047279507,0.108462542327436,FALSE +"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.32802,-0.88,0.538,1431,0.807,"indirubin",0.269217724333611,0.0931264652779296,FALSE +"H2126","Pearson.est","growth factor receptor inhibitor",0.47401,1.13,0.324,261,0.623,"PHA.848125, GSK1838705A, lestaurtinib, AZD3463",0.489454989793388,0.20551195334083,FALSE +"H2126","Pearson.est","HCV inhibitor",0.48922,1.2,0.267,386,0.596,"narlaprevir, embelin, mericitabine",0.573488738635425,0.224753740259764,FALSE +"H2126","Pearson.est","HDAC inhibitor",-0.63626,-1.73,0.0338,1080,0.119,"vorinostat, R306465, panobinostat, scriptaid, AR.42, tacedinaline, romidepsin, PCI.24781, M.344, JNJ.26481585, givinostat, mocetinostat, SB.939, pyroxamide",1.47108329972235,0.924453038607469,TRUE +"H2126","Pearson.est","histamine receptor antagonist",0.29944,0.719,0.82,302,0.915,"cimetidine, pheniramine, astemizole, tiotidine, famotidine",0.0861861476162833,0.0385789059335517,FALSE +"H2126","Pearson.est","HMGCR inhibitor",0.91756,2.25,0,14,0,"fluvastatin, atorvastatin, mevastatin, pitavastatin",Inf,Inf,TRUE +"H2126","Pearson.est","HSP inhibitor",0.45381,1.11,0.361,326,0.642,"SNX.2112, NVP.AUY922, ganetespib, NMS.E973, BIIB021, SNX.5422, PU.H71",0.442492798094342,0.192464971931147,FALSE +"H2126","Pearson.est","JAK inhibitor",0.35905,0.864,0.633,503,0.902,"tozasertib, AT.9283, lestaurtinib, AZ960, PRT062070, TG.101209, TG.101348",0.198596289982645,0.0447934624580583,FALSE +"H2126","Pearson.est","KIT inhibitor",0.49951,1.21,0.256,634,0.602,"KI.8751, sunitinib, midostaurin, motesanib, regorafenib, cediranib, pazopanib, lenvatinib, telatinib, dasatinib, sorafenib, OSI.930, masitinib",0.59176003468815,0.220403508742175,FALSE +"H2126","Pearson.est","MDM inhibitor",-0.31739,-0.829,0.669,1421,0.856,"RITA",0.174573882232177,0.0675262353228468,FALSE +"H2126","Pearson.est","MEK inhibitor",0.32807,0.808,0.671,755,0.876,"PD.318088, U.0126, cobimetinib, AZD8330, PD.0325901, refametinib, TAK.733, Ro.4987655, AS.703026, arctigenin, MEK162, BIX.02188",0.173277479831008,0.0574958938319193,FALSE +"H2126","Pearson.est","MET inhibitor",-0.4006,-1.03,0.415,1387,0.727,"NVP.BVU972, INC.280",0.381951903287907,0.138465589140962,FALSE +"H2126","Pearson.est","microtubule inhibitor",0.67524,1.66,0.0368,173,0.208,"vinblastine, vinflunine, podophyllotoxin, cabazitaxel, secnidazole",1.43415218132648,0.681936665037238,TRUE +"H2126","Pearson.est","mTOR inhibitor",-0.33124,-0.886,0.537,1111,0.847,"XL388, torin.2, voxtalisib, palomid.529, PP242, WYE.125132, PF.05212384, GDC.0980, PI.103, GSK2126458",0.270025714300444,0.0721165896692931,FALSE +"H2126","Pearson.est","NFkB pathway inhibitor",-0.18063,-0.478,0.989,1203,1,"Ro.106.9920, EVP4593, tyloxapol",0.0048037084028206,0,FALSE +"H2126","Pearson.est","opioid receptor agonist",0.56838,1.37,0.131,460,0.52,"spiradoline, cebranopadol, trimebutine, BW.180C",0.882728704344236,0.283996656365201,FALSE +"H2126","Pearson.est","p38 MAPK inhibitor",-0.4372,-1.17,0.273,630,0.711,"skepinone.l, TAK.715, CMPD.1, SB.242235, VX.702, talmapimod, SB.239063",0.563837352959244,0.148130399270234,FALSE +"H2126","Pearson.est","PARP inhibitor",0.5628,1.41,0.102,275,0.5,"talazoparib, niraparib, olaparib",0.991399828238082,0.301029995663981,FALSE +"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.52686,1.27,0.207,548,0.581,"ponatinib, KI.8751, SU014813, axitinib, dovitinib, CP.673451, sunitinib, motesanib, regorafenib, pazopanib, lenvatinib, telatinib, nintedanib, crenolanib, dasatinib, sorafenib",0.684029654543082,0.235823867609669,FALSE +"H2126","Pearson.est","phosphatase inhibitor",0.56742,1.39,0.122,97,0.509,"bis.maltolato.oxovanadium.IV., BVT.948, sodium.stibogluconate, GSK2830371",0.913640169325252,0.293282217663241,FALSE +"H2126","Pearson.est","phosphodiesterase inhibitor",0.40722,1.01,0.462,250,0.775,"anagrelide, GSK256066, YM.976",0.335358024443874,0.11069829749369,FALSE +"H2126","Pearson.est","PI3K inhibitor",-0.44974,-1.2,0.243,1207,0.732,"CUDC.907, PI3K.IN.2, PI.828, PF.05212384, GDC.0980, PI.103, GSK2126458, CH5132799, alpelisib, taselisib",0.614393726401688,0.135488918941608,FALSE +"H2126","Pearson.est","PLK inhibitor",0.59805,1.46,0.0655,512,0.464,"rigosertib, GSK461364, volasertib, GW.843682X, HMN.214, BI.2536",1.18375870000822,0.333482019445119,FALSE +"H2126","Pearson.est","potassium channel blocker",0.30974,0.742,0.793,609,0.901,"dofetilide, mepivacaine, meglitinide",0.100726812682396,0.045275209020937,FALSE +"H2126","Pearson.est","PPAR receptor agonist",0.3599,0.856,0.646,140,0.895,"fenofibrate",0.189767482004916,0.048176964684088,FALSE +"H2126","Pearson.est","progesterone receptor agonist",0.3669,0.868,0.626,476,0.916,"norethindrone, tanaproget, danazol",0.20342566678957,0.0381045263321496,FALSE +"H2126","Pearson.est","proteasome inhibitor",0.68299,1.7,0.0141,294,0.357,"ixazomib, bortezomib, delanzomib, MG.132, carfilzomib",1.85078088734462,0.447331783887807,FALSE +"H2126","Pearson.est","protein synthesis inhibitor",0.49112,1.18,0.264,205,0.589,"brefeldin.a, mercaptopurine, cycloheximide, methacycline, homoharringtonine",0.578396073130169,0.229884705212898,FALSE +"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.75244,-1.93,0.00592,1249,0.0545,"tyrphostin.A9, mubritinib, AV.412, BMS.599626, CP.724714",2.22767829327708,1.26360349772336,TRUE +"H2126","Pearson.est","RAF inhibitor",0.66605,1.58,0.043,247,0.281,"dabrafenib, vemurafenib, RAF265, GDC.0879, LGX818, AZ.628, regorafenib",1.36653154442041,0.55129368009492,FALSE +"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.31953,0.775,0.739,247,0.89,"sunitinib, regorafenib",0.131355561605174,0.0506099933550872,FALSE +"H2126","Pearson.est","retinoid receptor agonist",0.3507,0.851,0.645,234,0.884,"adarotene, tamibarotene",0.190440285364732,0.0535477349869269,FALSE +"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.53448,1.29,0.185,428,0.597,"cladribine, clofarabine, triapine, fludarabine.phosphate, LY2334737, pentostatin, gemcitabine",0.732828271596986,0.224025668870631,FALSE +"H2126","Pearson.est","serotonin receptor agonist",0.67564,1.67,0.0259,267,0.272,"aripiprazole, NAN.190, ipsapirone, SR.57227A",1.58670023591875,0.565431095965801,FALSE +"H2126","Pearson.est","serotonin receptor antagonist",0.37798,0.916,0.567,119,0.867,"aripiprazole, lerisetron, paliperidone",0.246416941107093,0.0619809025237897,FALSE +"H2126","Pearson.est","sodium channel blocker",0.18867,0.455,0.994,516,0.991,"quinidine, mexiletine, benzocaine, mepivacaine",0.00261361560268669,0.00392634551472468,FALSE +"H2126","Pearson.est","src inhibitor",-0.39411,-1.05,0.361,1411,0.748,"ZM.306416, saracatinib",0.442492798094342,0.126098402135539,FALSE +"H2126","Pearson.est","sterol demethylase inhibitor",0.53761,1.29,0.18,571,0.597,"ketoconazole, posaconazole, lanoconazole, terconazole, chlormidazole",0.744727494896694,0.224025668870631,FALSE +"H2126","Pearson.est","TGF beta receptor inhibitor",-0.41401,-1.1,0.341,597,0.71,"D.4476, LY2109761, adaprev, SB.525334, SB.431542, repsox",0.467245621007502,0.148741651280925,FALSE +"H2126","Pearson.est","thymidylate synthase inhibitor",0.67145,1.63,0.0316,338,0.227,"raltitrexed, trifluridine, carmofur, ftorafur",1.5003129173816,0.643974142806877,TRUE +"H2126","Pearson.est","topoisomerase inhibitor",0.62204,1.49,0.089,286,0.434,"topotecan, etoposide.phosphate, teniposide, rubitecan, daunorubicin, nemorubicin, irinotecan, doxorubicin, voreloxin, SN.38, TAS.103, etoposide, idarubicin, amsacrine, dexrazoxane",1.05060999335509,0.362510270487489,FALSE +"H2126","Pearson.est","tubulin polymerization inhibitor",0.69618,1.66,0.0235,305,0.208,"verubulin, vinblastine, BNC105, taltobulin, vindesine, podophyllotoxin, CYT.997, docetaxel, vincristine, dolastatin.10, combretastatin.A.4, plinabulin, paclitaxel, fosbretabulin, ABT.751, vinorelbine, KX2.391, epothilone.b, indibulin",1.62893213772826,0.681936665037238,TRUE +"H2126","Pearson.est","tyrosine kinase inhibitor",-0.41526,-1.13,0.278,1320,0.716,"GTP.14564, mubritinib, vandetanib, AV.412, BMS.599626, CP.724714",0.555955204081924,0.145086977692144,FALSE +"H2126","Pearson.est","VEGFR inhibitor",-0.27477,-0.746,0.796,1382,0.867,"vandetanib, semaxanib, ZM.306416, AEE788, XL.647, BMS.690514",0.0990869322623309,0.0619809025237897,FALSE +"H2126","Pearson.est","vitamin D receptor agonist",-0.82106,-2.23,0,1345,0.0182,"ercalcitriol, paricalcitol, calcitriol, tacalcitol, maxacalcitol",Inf,1.73992861201493,TRUE +"H520","Pearson.est","EGFR inhibitor",0.72338,1.79,0.0174,130,0.191,"poziotinib, PD.153035, vandetanib, icotinib, erlotinib, pelitinib, XL.647, gefitinib, BIBU.1361, afatinib, dacomitinib, osimertinib, AZD8931, canertinib, lapatinib, AST.1306, neratinib, BMS.599626, PD.168393",1.7594507517174,0.718966632752272,TRUE +"H520","Pearson.est","Abl kinase inhibitor",0.6975,1.75,0.0153,321,0.197,"dasatinib, bosutinib, ZM.306416, GZD824, metatinib, ponatinib, nilotinib",1.8153085691824,0.705533773838407,TRUE +"H520","Pearson.est","acetylcholine receptor agonist",0.38711,0.955,0.522,201,0.98,"nicotine, pilocarpine",0.282329496997738,0.00877392430750515,FALSE +"H520","Pearson.est","acetylcholine receptor antagonist",-0.38687,-1.01,0.391,1404,0.993,"diphemanil",0.407823242604133,0.00305075150461883,FALSE +"H520","Pearson.est","adenosine receptor antagonist",0.38874,0.962,0.509,292,1,"PSB.1115, CGS.15943",0.293282217663241,0,FALSE +"H520","Pearson.est","adrenergic receptor agonist",0.46375,1.14,0.312,273,0.728,"ritodrine, isoxsuprine, oxymetazoline, buphenine, epinephrine",0.505845405981557,0.137868620686963,FALSE +"H520","Pearson.est","adrenergic receptor antagonist",-0.23295,-0.62,0.907,1066,1,"carvedilol, practolol, propranolol, metoprolol, dihydroergocristine, pindolol",0.0423927129399047,0,FALSE +"H520","Pearson.est","AKT inhibitor",-0.27207,-0.699,0.802,1177,1,"GSK2110183, ONC201, GDC.0068, A.674563",0.0958256317158365,0,FALSE +"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.2398,0.598,0.917,149,0.985,"lorlatinib, GW.788388",0.0376306643299789,0.00656376950238827,FALSE +"H520","Pearson.est","androgen receptor antagonist",0.29131,0.721,0.823,470,0.965,"RU.58841, nilutamide, bicalutamide",0.0846001647877302,0.0154726866562074,FALSE +"H520","Pearson.est","antioxidant",0.54097,1.32,0.172,309,0.637,"mesna, chlorogenic.acid",0.764471553092451,0.19586056766465,FALSE +"H520","Pearson.est","AP inhibitor",0.6253,1.59,0.0516,286,0.311,"birinapant, GDC.0152, LCL.161, embelin",1.28735029837279,0.507239610973163,FALSE +"H520","Pearson.est","ATPase inhibitor",-0.44657,-1.16,0.287,1201,0.751,"omeprazole, digoxin, evodiamine, rabeprazole, oligomycin.a",0.542118103266008,0.124360062995832,FALSE +"H520","Pearson.est","Aurora kinase inhibitor",-0.65043,-1.67,0.0408,1202,0.429,"PF.03814735, danusertib, AT.9283, SNS.314, PHA.680632, AMG900, aurora.a.inhibitor.i, MK.8745, TAK.901, CCT137690, barasertib.HQPA, barasertib, ZM.447439",1.38933983691012,0.367542707815276,FALSE +"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.38886,0.948,0.496,48,0.956,"tedizolid",0.304518323509803,0.0195421077238999,FALSE +"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.37796,0.939,0.506,14,0.937,"finafloxacin",0.295849483160201,0.0282604091122217,FALSE +"H520","Pearson.est","BCL inhibitor",-0.37735,-0.965,0.437,1126,0.991,"navitoclax, TW.37, HA14.1, ABT.737, oridonin",0.359518563029578,0.00392634551472468,FALSE +"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.70004,1.74,0.0216,321,0.169,"dasatinib, bosutinib, GZD824, metatinib, ponatinib, nilotinib",1.66554624884907,0.772113295386326,TRUE +"H520","Pearson.est","benzodiazepine receptor agonist",0.31482,0.782,0.715,329,0.983,"lorazepam, piperazine, eprinomectin, CGS.20625",0.145693958198919,0.00744648216786438,FALSE +"H520","Pearson.est","bromodomain inhibitor",-0.72072,-1.92,0.00771,1120,0.35,"bromosporine, I.BET.762, PFI.1, I.BET151, OTX015",2.11294562194904,0.455931955649724,FALSE +"H520","Pearson.est","calcium channel blocker",0.38857,0.964,0.495,278,1,"SKF.96365, efonidipine.monoethanolate, cinnarazine",0.305394801066431,0,FALSE +"H520","Pearson.est","CC chemokine receptor antagonist",0.49066,1.21,0.243,132,0.746,"navarixin, ZK811752",0.614393726401688,0.127261172527331,FALSE +"H520","Pearson.est","CDK inhibitor",0.21788,0.544,0.949,511,0.956,"AZD5438, alvocidib, palbociclib, kenpaullone, JNJ.7706621, ribociclib, aminopurvalanol.a, AT.7519, PHA.848125, P276.00",0.0227337875727074,0.0195421077238999,FALSE +"H520","Pearson.est","CHK inhibitor",-0.62331,-1.64,0.0644,1318,0.329,"SB.218078, PF.477736",1.19111413264019,0.482804102050026,FALSE +"H520","Pearson.est","cyclooxygenase inhibitor",-0.26361,-0.694,0.798,1342,1,"AM.404, sulfasalazine, naproxen",0.0979971086492706,0,FALSE +"H520","Pearson.est","cytochrome P450 inhibitor",0.62174,1.51,0.0701,268,0.423,"morin, metyrapone, itraconazole",1.15428198203334,0.373659632624958,FALSE +"H520","Pearson.est","DNA alkylating agent",-0.36093,-0.94,0.498,1273,0.903,"melphalan, satraplatin, dianhydrogalactitol, mitomycin.c",0.302770657240282,0.0443122496864942,FALSE +"H520","Pearson.est","DNA inhibitor",-0.36156,-0.984,0.462,1166,1,"primaquine, tirapazamine, melphalan, bendamustine, pibenzimol, chlorambucil, valrubicin, mechlorethamine",0.335358024443874,0,FALSE +"H520","Pearson.est","DNA methyltransferase inhibitor",-0.28711,-0.775,0.728,993,1,"fdcyd, disulfiram, SGI.1027",0.137868620686963,0,FALSE +"H520","Pearson.est","DNA polymerase inhibitor",0.25074,0.622,0.886,304,1,"foscarnet, adefovir.dipivoxil",0.0525662781129492,0,FALSE +"H520","Pearson.est","DNA synthesis inhibitor",-0.31062,-0.811,0.664,1237,1,"estramustine.phosphate, artemisinin, azodicarbonamide, mitomycin.c",0.177831920631982,0,FALSE +"H520","Pearson.est","dopamine receptor antagonist",0.45375,1.14,0.315,399,0.728,"clebopride, acetophenazine, oxiperomide, isofloxythepin, amisulpride, domperidone, piperacetazine, UH.232....",0.501689446210399,0.137868620686963,FALSE +"H520","Pearson.est","estrogen receptor agonist",0.23476,0.579,0.927,463,0.978,"erteberel, PPT, estrone, ethinyl.estradiol",0.0329202658555029,0.00966114521239857,FALSE +"H520","Pearson.est","estrogen receptor antagonist",0.36681,0.909,0.542,221,0.896,"raloxifene, clomifene",0.266000713461613,0.0476919903378748,FALSE +"H520","Pearson.est","FGFR inhibitor",-0.53967,-1.42,0.118,1255,0.521,"dovitinib, regorafenib, erdafitinib, lenvatinib, nintedanib",0.928117992693875,0.283162276700476,FALSE +"H520","Pearson.est","FLT3 inhibitor",-0.23279,-0.612,0.901,913,1,"lestaurtinib, pacritinib, tozasertib, tyrphostin.AG.1296, midostaurin, quizartinib, TG.02, ENMD.2076, sorafenib, dovitinib, TG.101348",0.045275209020937,0,FALSE +"H520","Pearson.est","glucocorticoid receptor agonist",0.52123,1.31,0.169,259,0.609,"hydrocortisone, fluocinolone.acetonide, ciclesonide, dexamethasone.acetate, flumethasone.pivalate, triamcinolone.acetonide, halobetasol.propionate, prednisolone.acetate, desonide",0.772113295386326,0.215382707367125,FALSE +"H520","Pearson.est","glutamate receptor antagonist",0.28854,0.722,0.799,312,0.991,"SIB.1757, diazooxonorleucine, MTPG, latrepirdine",0.0974532206860086,0.00392634551472468,FALSE +"H520","Pearson.est","glycogen synthase kinase inhibitor",0.36965,0.931,0.548,356,0.885,"LY2090314, tideglusib, kenpaullone, TWS.119",0.261219441515631,0.0530567293021746,FALSE +"H520","Pearson.est","growth factor receptor inhibitor",0.36099,0.869,0.607,53,0.913,"GSK1904529A",0.216811308924742,0.039529222465701,FALSE +"H520","Pearson.est","HCV inhibitor",0.37946,0.932,0.517,341,0.917,"PSI.7976, embelin, daclatasvir",0.286509456906058,0.0376306643299789,FALSE +"H520","Pearson.est","HDAC inhibitor",-0.57682,-1.56,0.0765,1052,0.347,"belinostat, nexturastat.a, entinostat, mocetinostat, trichostatin.a, dacinostat, PCI.24781, NSC.3852, RGFP966, ACY.1215, givinostat, SB.939, R306465, vorinostat, resminostat, chidamide, pyroxamide, scriptaid, M.344",1.11633856484638,0.459670525209126,FALSE +"H520","Pearson.est","histamine receptor antagonist",0.28328,0.726,0.776,426,1,"astemizole, ranitidine, terfenadine, zolantidine, levocetirizine, tecastemizole, cimetidine",0.110138278741812,0,FALSE +"H520","Pearson.est","HMGCR inhibitor",0.53804,1.34,0.159,466,0.708,"lovastatin, fluvastatin, pitavastatin, simvastatin",0.798602875679548,0.149966742310231,FALSE +"H520","Pearson.est","HSP inhibitor",-0.33422,-0.893,0.547,1439,0.965,"NMS.E973",0.262012673666569,0.0154726866562074,FALSE +"H520","Pearson.est","JAK inhibitor",-0.21345,-0.575,0.954,1167,0.968,"PRT062070, LY2784544, AT.9283, ruxolitinib, TG.101348",0.0204516252959049,0.0141246426916063,FALSE +"H520","Pearson.est","KIT inhibitor",0.29841,0.734,0.809,1,1,"dasatinib",0.0920514783877277,0,FALSE +"H520","Pearson.est","MDM inhibitor",0.47695,1.19,0.267,332,0.744,"idasanutlin, nutlin.3",0.573488738635425,0.128427064454121,FALSE +"H520","Pearson.est","MEK inhibitor",0.79814,2.02,0.00514,44,0.0597,"TAK.733, AZD8330, trametinib, PD.0325901, cobimetinib, Ro.4987655, refametinib, AS.703026, selumetinib, PD.318088, MEK162",2.28903688100472,1.22402566887063,TRUE +"H520","Pearson.est","MET inhibitor",-0.28754,-0.741,0.802,1082,1,"NVP.BVU972, INC.280, AMG458",0.0958256317158365,0,FALSE +"H520","Pearson.est","microtubule inhibitor",-0.39052,-1.02,0.404,1237,1,"estramustine.phosphate, vinflunine, colchicine",0.393618634889395,0,FALSE +"H520","Pearson.est","mTOR inhibitor",0.54424,1.35,0.162,494,0.757,"WAY.600, torin.1, WYE.354, OSI.027, LY303511, XL388, PP242, GSK2126458, AZD8055, SB.2343, PF.04691502, AZD2014, MLN0128, voxtalisib, LY3023414, ku.0063794, NVP.BEZ235, temsirolimus",0.790484985457369,0.120904120499927,FALSE +"H520","Pearson.est","NFkB pathway inhibitor",-0.23904,-0.612,0.923,1423,1,"BAY.11.7082",0.0347982989740879,0,FALSE +"H520","Pearson.est","opioid receptor agonist",0.52359,1.33,0.155,288,0.666,"ADL5859, trimebutine, BW.180C",0.809668301829709,0.176525770829699,FALSE +"H520","Pearson.est","p38 MAPK inhibitor",0.2219,0.557,0.939,425,0.97,"TAK.715, VX.702",0.0273344077338891,0.0132282657337552,FALSE +"H520","Pearson.est","PARP inhibitor",-0.65403,-1.69,0.02,1296,0.514,"PJ.34, olaparib, AZD2461, niraparib, talazoparib",1.69897000433602,0.289036881004724,FALSE +"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.31053,-0.814,0.688,1089,1,"motesanib, sorafenib, trapidil, masitinib, axitinib, dovitinib, regorafenib, linifanib, lenvatinib, pazopanib, nintedanib",0.162411561764489,0,FALSE +"H520","Pearson.est","phosphatase inhibitor",-0.31279,-0.8,0.668,1034,1,"menadione, AS.1949490, mycophenolate.mofetil, CID.5458317",0.175223537524454,0,FALSE +"H520","Pearson.est","phosphodiesterase inhibitor",-0.21295,-0.555,0.956,1373,0.955,"enoximone",0.0195421077238999,0.0199966284162537,FALSE +"H520","Pearson.est","PI3K inhibitor",0.3208,0.806,0.689,480,1,"TG.100713, LY303511, AZD6482, GSK2126458, SB.2343, buparlisib, PF.04691502, GDC.0941, voxtalisib, LY3023414, NVP.BEZ235, PIK.75",0.161780778092374,0,FALSE +"H520","Pearson.est","PLK inhibitor",-0.70099,-1.82,0.0217,1189,0.378,"HMN.214, BI.2536, NMS.1286937, volasertib",1.66354026615147,0.422508200162775,FALSE +"H520","Pearson.est","potassium channel blocker",-0.2982,-0.78,0.714,430,1,"oleoylethanolamide, mepivacaine, meglitinide, ML133, ibutilide, dofetilide",0.146301788223826,0,FALSE +"H520","Pearson.est","PPAR receptor agonist",-0.51085,-1.35,0.153,1170,0.536,"pterostilbene, clofibrate, ciprofibrate, GW.501516",0.815308569182401,0.27083521030723,FALSE +"H520","Pearson.est","progesterone receptor agonist",-0.23141,-0.609,0.894,333,0.993,"melengestrol.acetate, nomegestrol.acetate, levonorgestrel, norethindrone, dienogest, tanaproget, norethindrone.acetate, norgestrel, danazol",0.0486624812040823,0.00305075150461883,FALSE +"H520","Pearson.est","proteasome inhibitor",-0.26018,-0.677,0.848,1096,1,"oprozomib, delanzomib, MG.132",0.0716041477432862,0,FALSE +"H520","Pearson.est","protein synthesis inhibitor",-0.3581,-0.951,0.483,1246,0.971,"azomycin..2.nitroimidazole., harringtonine, bruceantin, homoharringtonine, clofoctol, anguidine",0.316052869248488,0.0127807700919951,FALSE +"H520","Pearson.est","protein tyrosine kinase inhibitor",0.27985,0.689,0.824,487,0.984,"BMS.599626, PP.121, AV.412, NVP.TAE226",0.0840727883028842,0.00700490156865849,FALSE +"H520","Pearson.est","RAF inhibitor",0.43296,1.09,0.365,305,0.795,"LGX818, AZ.628, CEP.32496, dabrafenib, vemurafenib, SB.590885",0.437707135543525,0.0996328713435297,FALSE +"H520","Pearson.est","RET tyrosine kinase inhibitor",0.52403,1.3,0.188,17,0.584,"vandetanib",0.72584215073632,0.233587152887601,FALSE +"H520","Pearson.est","retinoid receptor agonist",-0.49046,-1.25,0.231,1216,0.669,"adarotene, adapalene, bexarotene, fenretinide",0.636388020107856,0.174573882232177,FALSE +"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.60728,-1.6,0.061,1025,0.339,"gemcitabine, cladribine, fludarabine, clofarabine, hydroxyurea, cytarabine, pentostatin",1.21467016498923,0.469800301796918,FALSE +"H520","Pearson.est","serotonin receptor agonist",-0.52589,-1.39,0.145,1361,0.517,"zolmitriptan, aripiprazole",0.838631997765025,0.286509456906058,FALSE +"H520","Pearson.est","serotonin receptor antagonist",-0.35474,-0.949,0.506,1447,0.927,"aripiprazole",0.295849483160201,0.0329202658555029,FALSE +"H520","Pearson.est","sodium channel blocker",-0.22785,-0.604,0.908,1203,0.97,"brivaracetam, triamterene, oxcarbazepine, cibenzoline",0.0419141514789149,0.0132282657337552,FALSE +"H520","Pearson.est","src inhibitor",0.6866,1.69,0.0371,83,0.202,"dasatinib, PP.2, saracatinib, bosutinib, ZM.306416",1.43062609038495,0.694648630553376,TRUE +"H520","Pearson.est","sterol demethylase inhibitor",0.36398,0.906,0.552,169,0.871,"sulconazole, terconazole",0.258060922270801,0.0599818449923368,FALSE +"H520","Pearson.est","TGF beta receptor inhibitor",0.45947,1.14,0.297,92,0.728,"repsox",0.527243550682788,0.137868620686963,FALSE +"H520","Pearson.est","thymidylate synthase inhibitor",0.73357,1.8,0.00984,313,0.269,"carmofur, capecitabine, ftorafur, raltitrexed",2.00700490156866,0.570247719997592,FALSE +"H520","Pearson.est","topoisomerase inhibitor",-0.62958,-1.65,0.0622,1121,0.376,"amsacrine, irinotecan, genz.644282, dexrazoxane, teniposide, voreloxin, doxorubicin, daunorubicin, mitoxantrone, topotecan, valrubicin, etoposide, amonafide, nemorubicin, etoposide.phosphate, epirubicin",1.20620961530918,0.424812155072339,FALSE +"H520","Pearson.est","tubulin polymerization inhibitor",-0.4619,-1.19,0.281,945,0.74,"epothilone.d, dolastatin.10, mebendazole, vindesine, BNC105, vinorelbine, verubulin, fosbretabulin, vincristine, CYT.997, flubendazole, ABT.751, albendazole, combretastatin.A.4, fenbendazole, taltobulin, KX2.391",0.55129368009492,0.130768280269024,FALSE +"H520","Pearson.est","tyrosine kinase inhibitor",0.32734,0.803,0.69,126,0.975,"dasatinib, vandetanib, BMS.599626",0.161150909262745,0.0109953843014632,FALSE +"H520","Pearson.est","VEGFR inhibitor",0.24002,0.599,0.934,178,1,"vandetanib, XL.647, ZM.306416, SU014813, BMS.690514, lucitanib",0.0296531237699066,0,FALSE +"H520","Pearson.est","vitamin D receptor agonist",0.26865,0.688,0.813,310,0.96,"ercalcitriol, tacalcitol",0.0899094544059319,0.0177287669604316,FALSE +"H460","Pearson.est","EGFR inhibitor",0.18479,0.566,0.918,1188,1,"tucatinib, BMS.690514, canertinib, AZD8931, tyrphostin.AG.494, lapatinib, FERb.033, neratinib, PD.168393, brigatinib, XL.647, poziotinib, icotinib, ARRY.334543, GW.583340, salvianolic.acid.B, osimertinib, gefitinib, erlotinib, dacomitinib, TAK.285, vandetanib, BIBX.1382, WZ8040, CP.724714, afatinib, WZ.3146, rociletinib, AEE788, tyrphostin.AG.1478, CGP.52411, dovitinib, pelitinib, OSI.420, PD.153035, BMS.599626, CUDC.101, BIBU.1361, CNX.2006, WZ.4002, AST.1306",0.0371573187987575,0,FALSE +"H460","Pearson.est","Abl kinase inhibitor",-0.41326,-0.993,0.482,792,0.942,"ponatinib, flumatinib, GZD824, metatinib, tozasertib, nilotinib, KW.2449, bosutinib",0.31695296176115,0.0259490972071227,FALSE +"H460","Pearson.est","acetylcholine receptor agonist",-0.32193,-0.785,0.747,755,1,"tremorine, nicotine, pilocarpine, oxiracetam",0.126679398184601,0,FALSE +"H460","Pearson.est","acetylcholine receptor antagonist",0.4896,1.51,0.065,742,0.561,"diphemanil, darifenacin, iododexetimide, dicycloverine, hyoscyamine, methscopolamine",1.18708664335714,0.251037138743839,FALSE +"H460","Pearson.est","adenosine receptor antagonist",-0.22484,-0.547,0.974,1255,1,"istradefylline",0.0114410431213845,0,FALSE +"H460","Pearson.est","adrenergic receptor agonist",-0.24893,-0.61,0.935,916,1,"lidamidine, midodrine, oxymetazoline, buphenine, clenbuterol",0.0291883891274822,0,FALSE +"H460","Pearson.est","adrenergic receptor antagonist",-0.46215,-1.12,0.339,1247,0.873,"carvedilol, imiloxan, atipamezole, oxprenolol, vincamine",0.469800301796918,0.0589857562944303,FALSE +"H460","Pearson.est","AKT inhibitor",0.19385,0.6,0.919,123,1,"GDC.0068, GSK2110183, MK.2206",0.0366844886138887,0,FALSE +"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.31824,-0.766,0.804,1441,1,"AZD3463",0.0947439512515487,0,FALSE +"H460","Pearson.est","androgen receptor antagonist",-0.40086,-0.974,0.498,712,0.89,"cyproterone.acetate, RU.58841, nilutamide",0.302770657240282,0.0506099933550872,FALSE +"H460","Pearson.est","antioxidant",-0.55753,-1.33,0.122,851,0.598,"rutin, taurine, trolox, chlorogenic.acid, mesna",0.913640169325252,0.223298816011589,FALSE +"H460","Pearson.est","AP inhibitor",-0.39117,-0.926,0.594,635,0.988,"tanshinone.i, birinapant, embelin, LCL.161",0.226213555018806,0.00524305541237188,FALSE +"H460","Pearson.est","ATPase inhibitor",-0.37845,-0.917,0.582,939,0.961,"digitoxin, blebbistatin...., evodiamine, digitoxigenin, NMS.873, digoxin",0.235077015350112,0.0172766123314547,FALSE +"H460","Pearson.est","Aurora kinase inhibitor",-0.63544,-1.53,0.0347,1021,0.324,"MK.8745, tozasertib, barasertib, barasertib.HQPA, CCT129202, MLN.8054, KW.2449, CCT137690, MK.5108, alisertib, GSK1070916, PHA.680632, AMG900, ENMD.2076, danusertib, SNS.314, AT.9283, hesperadin, PF.03814735",1.45967052520913,0.489454989793388,FALSE +"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.54304,-1.33,0.127,1243,0.598,"tedizolid, radezolid, valnemulin",0.896196279044043,0.223298816011589,FALSE +"H460","Pearson.est","bacterial DNA gyrase inhibitor",-0.44114,-1.07,0.389,1438,0.863,"finafloxacin",0.410050398674292,0.0639892042847904,FALSE +"H460","Pearson.est","BCL inhibitor",-0.44563,-1.08,0.347,1396,0.896,"TW.37, gossypol",0.459670525209126,0.0476919903378748,FALSE +"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.41786,-0.998,0.462,792,0.956,"ponatinib, flumatinib, GZD824, metatinib, tozasertib, nilotinib, bosutinib",0.335358024443874,0.0195421077238999,FALSE +"H460","Pearson.est","benzodiazepine receptor agonist",0.26698,0.813,0.687,117,0.931,"CL.218872, indiplon, bentazepam, nefiracetam",0.16304326294045,0.0310503190186574,FALSE +"H460","Pearson.est","bromodomain inhibitor",-0.42727,-1.02,0.432,643,0.92,"OTX015, PFI.1, JQ1...., I.BET.762, bromosporine",0.364516253185088,0.0362121726544447,FALSE +"H460","Pearson.est","calcium channel blocker",-0.51528,-1.27,0.155,1077,0.706,"cinnarazine, carboxyamidotriazole, mibefradil, tetrandrine",0.809668301829709,0.151195298948196,FALSE +"H460","Pearson.est","CC chemokine receptor antagonist",-0.48901,-1.19,0.254,1215,0.761,"ZK811752, SB.225002, navarixin",0.595166283380062,0.118615343229427,FALSE +"H460","Pearson.est","CDK inhibitor",-0.54832,-1.33,0.115,1126,0.598,"BMS.387032, R547, PHA.793887, aminopurvalanol.a, JNJ.7706621, TG.02, kenpaullone, alvocidib, BMS.265246, ribociclib, abemaciclib, AZD5438, palbociclib",0.939302159646388,0.223298816011589,FALSE +"H460","Pearson.est","CHK inhibitor",0.4275,1.27,0.22,215,0.571,"PF.477736, SCH.900776, LY2606368, LY2603618",0.657577319177794,0.243363891754152,FALSE +"H460","Pearson.est","cyclooxygenase inhibitor",-0.34487,-0.834,0.718,1111,1,"tepoxalin, piroxicam, tryptanthrin, ketoprofen, indoprofen, FR.122047",0.1438755557577,0,FALSE +"H460","Pearson.est","cytochrome P450 inhibitor",-0.32168,-0.785,0.773,619,1,"eplerenone, cobicistat, morin, itraconazole",0.111820506081675,0,FALSE +"H460","Pearson.est","DNA alkylating agent",-0.39955,-0.984,0.484,655,0.913,"dianhydrogalactitol, temozolomide, cyclophosphamide, estramustine, carboplatin, satraplatin, TH.302, streptozotocin, melphalan, carmustine, mitomycin.c",0.315154638355588,0.039529222465701,FALSE +"H460","Pearson.est","DNA inhibitor",-0.35353,-0.847,0.685,1290,1,"melphalan, teroxirone, carmustine, oxaliplatin",0.164309428507574,0,FALSE +"H460","Pearson.est","DNA methyltransferase inhibitor",-0.25337,-0.62,0.916,591,1,"disulfiram, fdcyd, azacitidine, RG108, decitabine",0.0381045263321496,0,FALSE +"H460","Pearson.est","DNA polymerase inhibitor",-0.65464,-1.58,0.026,1283,0.303,"foscarnet, trifluridine, idoxuridine",1.58502665202918,0.518557371497695,FALSE +"H460","Pearson.est","DNA synthesis inhibitor",-0.51182,-1.23,0.195,1101,0.711,"artesunate, enocitabine, CB.10.277, floxuridine, mitomycin.c, cyclocytidine, anisomycin",0.709965388637482,0.148130399270234,FALSE +"H460","Pearson.est","dopamine receptor antagonist",-0.40495,-0.982,0.483,1050,0.894,"amisulpride, piperacetazine, domperidone, mesoridazine, sertindole, raclopride, oxiperomide, paliperidone, UH.232....",0.316052869248488,0.0486624812040823,FALSE +"H460","Pearson.est","estrogen receptor agonist",0.27473,0.834,0.692,139,0.969,"estradiol.cypionate, equol, levonorgestrel, ethinyl.estradiol",0.159893905543242,0.0136762229492347,FALSE +"H460","Pearson.est","estrogen receptor antagonist",0.32837,1.01,0.439,4,0.75,"toremifene",0.357535479757879,0.1249387366083,FALSE +"H460","Pearson.est","FGFR inhibitor",0.33102,1.05,0.326,972,0.74,"erdafitinib, lenvatinib, AZD4547, orantinib, nintedanib, lucitanib, dovitinib, MK.2461, regorafenib, PD.173074",0.486782399932061,0.130768280269024,FALSE +"H460","Pearson.est","FLT3 inhibitor",-0.44515,-1.07,0.379,792,0.863,"ponatinib, dovitinib, midostaurin, TG.101348, lestaurtinib, tozasertib, gilteritinib, sunitinib, pacritinib, KW.2449, TG.02, ENMD.2076, quizartinib",0.421360790031928,0.0639892042847904,FALSE +"H460","Pearson.est","glucocorticoid receptor agonist",-0.32852,-0.804,0.729,934,1,"desonide, flumethasone.pivalate, fluticasone.propionate, halcinonide, prednisolone, rimexolone, flumethasone, halobetasol.propionate, fluocinolone.acetonide, ciclesonide, hydrocortisone",0.137272471682025,0,FALSE +"H460","Pearson.est","glutamate receptor antagonist",0.35052,1.08,0.31,945,0.767,"felbamate, CGP.37849, JNJ.16259685, tiletamine, kynurenic.acid, IEM1754, MTPG, LY456236, CPP, latrepirdine, diazooxonorleucine, ACDPP, SIB.1757",0.508638306165727,0.115204636051019,FALSE +"H460","Pearson.est","glycogen synthase kinase inhibitor",-0.22609,-0.556,0.962,946,1,"TWS.119, tideglusib, kenpaullone",0.0168249279621871,0,FALSE +"H460","Pearson.est","growth factor receptor inhibitor",-0.58048,-1.38,0.104,901,0.648,"PHA.848125, lestaurtinib, GSK1904529A, GSK1838705A, danusertib, AZD3463",0.98296666070122,0.188424994129407,FALSE +"H460","Pearson.est","HCV inhibitor",-0.43235,-1.05,0.399,1217,0.892,"narlaprevir, mericitabine",0.399027104313252,0.0496351456238769,FALSE +"H460","Pearson.est","HDAC inhibitor",-0.21266,-0.512,0.98,574,0.993,"RGFP966, scriptaid, R306465, resminostat, romidepsin, JNJ.26481585, belinostat, trichostatin.a, AR.42, PCI.24781, RG2833, entinostat, givinostat, SB.939, dacinostat",0.00877392430750515,0.00305075150461883,FALSE +"H460","Pearson.est","histamine receptor antagonist",-0.21489,-0.523,0.983,763,1,"levocetirizine, nizatidine, terfenadine, zolantidine, astemizole, BF2.649, pheniramine, tiotidine",0.00744648216786438,0,FALSE +"H460","Pearson.est","HMGCR inhibitor",0.55687,1.7,0.0521,645,0.509,"pitavastatin, lovastatin, atorvastatin, mevastatin, fluvastatin, simvastatin",1.28316227670048,0.293282217663241,FALSE +"H460","Pearson.est","HSP inhibitor",-0.49358,-1.18,0.264,1207,0.757,"ganetespib, SNX.2112, NVP.AUY922, tanespimycin, PU.H71",0.578396073130169,0.120904120499927,FALSE +"H460","Pearson.est","JAK inhibitor",-0.43913,-1.04,0.423,1041,0.89,"tozasertib, AZD1480, pacritinib, AZ960, WHI.P154, TG.101209, TG.02, AT.9283, filgotinib",0.373659632624958,0.0506099933550872,FALSE +"H460","Pearson.est","KIT inhibitor",-0.31204,-0.755,0.82,1151,1,"OSI.930, sunitinib, vatalanib, KI.8751",0.0861861476162833,0,FALSE +"H460","Pearson.est","MDM inhibitor",-0.73615,-1.81,0.00224,1170,0.0784,"RITA, idasanutlin, CGM097, serdemetan, nutlin.3",2.64975198166584,1.10568393731556,TRUE +"H460","Pearson.est","MEK inhibitor",-0.77946,-1.91,0,1195,0.0811,"arctigenin, cobimetinib, refametinib, PD.198306, MEK162, trametinib, PD.184352, selumetinib, AS.703026, nobiletin, PD.318088, PD.0325901, TAK.733, AZD8330, Ro.4987655",Inf,1.09097914578884,TRUE +"H460","Pearson.est","MET inhibitor",0.46325,1.47,0.0696,780,0.439,"INC.280, NVP.BVU972, AMG458, PF.04217903, LY2801653, PHA.665752",1.15739076038944,0.357535479757879,FALSE +"H460","Pearson.est","microtubule inhibitor",-0.71337,-1.72,0.00682,1275,0.148,"cabazitaxel, secnidazole, vinflunine, D.64131, vinblastine, podophyllotoxin",2.16621562534352,0.829738284605043,TRUE +"H460","Pearson.est","mTOR inhibitor",-0.40351,-0.987,0.497,737,0.932,"palomid.529, torin.2, WYE.125132, voxtalisib, SB.2343, PKI.179, deforolimus, LY303511, GSK2126458, NVP.BEZ235, AZD2014, PP242, WAY.600, AZD8055, MLN0128, XL388, torin.1, WYE.354, ku.0063794",0.303643611266668,0.0305840876460186,FALSE +"H460","Pearson.est","NFkB pathway inhibitor",-0.21219,-0.509,0.977,719,0.979,"Ro.106.9920, parthenolide, bortezomib, betulinic.acid, EVP4593",0.0101054362812269,0.00921730819686218,FALSE +"H460","Pearson.est","opioid receptor agonist",-0.55926,-1.37,0.101,950,0.622,"spiradoline, cebranopadol, salvinorin.a, trimebutine",0.995678626217357,0.206209615309181,FALSE +"H460","Pearson.est","p38 MAPK inhibitor",0.32824,0.98,0.471,975,0.738,"talmapimod, SB.239063, TAK.715, SB.242235, VX.702, CMPD.1, skepinone.l",0.326979092871104,0.131943638176958,FALSE +"H460","Pearson.est","PARP inhibitor",-0.51074,-1.24,0.186,908,0.72,"AZD2461, niraparib, PJ.34, AG.14361, E7449, talazoparib",0.730487055782084,0.142667503568732,FALSE +"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.25466,-0.615,0.93,742,1,"axitinib, ponatinib, trapidil, dovitinib, regorafenib, CP.673451, SU014813, sunitinib, vatalanib, crenolanib, KI.8751",0.0315170514460649,0,FALSE +"H460","Pearson.est","phosphatase inhibitor",0.14882,0.434,1,1234,0.995,"menadione, alexidine, BVT.948, AS.1949490, mycophenolate.mofetil, CID.5458317, bis.maltolato.oxovanadium.IV., sodium.stibogluconate, mycophenolic.acid, GSK2830371",0,0.00217691925427455,FALSE +"H460","Pearson.est","phosphodiesterase inhibitor",0.20376,0.638,0.965,1155,1,"enoximone, trequinsin, avanafil, anagrelide, cilostamide, papaverine, YM.976, zardaverine, GSK256066, EMD.53998",0.0154726866562074,0,FALSE +"H460","Pearson.est","PI3K inhibitor",-0.24808,-0.599,0.934,764,1,"BGT226, voxtalisib, GDC.0941, SB.2343, TG.100713, PKI.179, LY303511, GSK2126458, CUDC.907, NVP.BEZ235, YM.201636, PIK.75, ZSTK.474",0.0296531237699066,0,FALSE +"H460","Pearson.est","PLK inhibitor",-0.75156,-1.85,0.00554,1083,0.0797,"GW.843682X, BI.2536, NMS.1286937, GSK461364, HMN.214, volasertib, rigosertib",2.25649023527157,1.09854167860389,TRUE +"H460","Pearson.est","potassium channel blocker",-0.33703,-0.821,0.732,486,1,"dofetilide, meglitinide, mepivacaine, ibutilide, ML133, oleoylethanolamide",0.135488918941608,0,FALSE +"H460","Pearson.est","PPAR receptor agonist",-0.23955,-0.58,0.944,1015,1,"ciprofibrate, oleoylethanolamide",0.025028005701931,0,FALSE +"H460","Pearson.est","progesterone receptor agonist",-0.26975,-0.667,0.892,953,1,"dienogest, melengestrol.acetate, tanaproget",0.0496351456238769,0,FALSE +"H460","Pearson.est","proteasome inhibitor",0.39375,1.2,0.224,881,0.602,"delanzomib, ONX.0914, oprozomib, carfilzomib, ixazomib.citrate, MG.132, bortezomib, ixazomib",0.649751981665837,0.220403508742175,FALSE +"H460","Pearson.est","protein synthesis inhibitor",-0.63246,-1.55,0.0355,1285,0.324,"emetine, brefeldin.a, mercaptopurine, harringtonine, anguidine, bruceantin, cycloheximide, homoharringtonine",1.44977164694491,0.489454989793388,FALSE +"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.33269,-0.802,0.741,888,1,"mubritinib, BMS.599626, tyrphostin.A9, NVP.TAE226",0.130181792020672,0,FALSE +"H460","Pearson.est","RAF inhibitor",-0.50483,-1.24,0.201,1105,0.72,"SB.590885, CEP.32496, RAF265, dabrafenib, LGX818, AZ.628, GDC.0879",0.696803942579511,0.142667503568732,FALSE +"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.34496,-0.836,0.705,873,1,"regorafenib, cabozantinib, sunitinib",0.151810883008601,0,FALSE +"H460","Pearson.est","retinoid receptor agonist",-0.35923,-0.87,0.655,1392,1,"adarotene",0.183758700008217,0,FALSE +"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.44285,-1.08,0.369,924,0.896,"gemcitabine, cladribine, triapine, clofarabine, LY2334737",0.43297363384094,0.0476919903378748,FALSE +"H460","Pearson.est","serotonin receptor agonist",-0.53638,-1.3,0.123,1447,0.652,"aripiprazole",0.910094888560602,0.18575240426808,FALSE +"H460","Pearson.est","serotonin receptor antagonist",-0.44652,-1.08,0.356,1068,0.896,"pirenperone, sertindole, paliperidone, SB.200646, aripiprazole",0.448550002027125,0.0476919903378748,FALSE +"H460","Pearson.est","sodium channel blocker",-0.38465,-0.923,0.591,1013,0.971,"triamterene, butamben, mexiletine, benzethonium, ajmaline, A.803467",0.228412519118745,0.0127807700919951,FALSE +"H460","Pearson.est","src inhibitor",-0.46449,-1.12,0.321,1133,0.873,"KX2.391, PP.2, TG.100572, bosutinib",0.493494967595128,0.0589857562944303,FALSE +"H460","Pearson.est","sterol demethylase inhibitor",-0.30791,-0.75,0.793,444,1,"posaconazole, chlormidazole, sulconazole, terconazole, lanoconazole, ketoconazole",0.100726812682396,0,FALSE +"H460","Pearson.est","TGF beta receptor inhibitor",0.42926,1.33,0.149,829,0.575,"LY2109761, SB.431542, repsox, D.4476, SB.525334, adaprev",0.826813731587726,0.24033215531037,FALSE +"H460","Pearson.est","thymidylate synthase inhibitor",-0.61761,-1.5,0.0411,1141,0.351,"ftorafur, trifluridine, raltitrexed, carmofur",1.38615817812393,0.454692883534176,FALSE +"H460","Pearson.est","topoisomerase inhibitor",-0.50043,-1.2,0.243,833,0.767,"irinotecan, nemorubicin, doxorubicin, camptothecin, SN.38, topotecan, exatecan.mesylate, fleroxacin, dexrazoxane, rubitecan, valrubicin, genz.644282, daunorubicin, voreloxin, teniposide, amonafide, idarubicin, amsacrine, TAS.103",0.614393726401688,0.115204636051019,FALSE +"H460","Pearson.est","tubulin polymerization inhibitor",-0.66396,-1.59,0.0233,1027,0.338,"mebendazole, oxibendazole, paclitaxel, KX2.391, vindesine, indibulin, vincristine, plinabulin, nocodazole, CYT.997, docetaxel, ABT.751, BNC105, vinorelbine, vinblastine, dolastatin.10, podophyllotoxin, parbendazole, combretastatin.A.4, albendazole, taltobulin, verubulin, epothilone.b, fosbretabulin",1.63264407897398,0.471083299722345,FALSE +"H460","Pearson.est","tyrosine kinase inhibitor",-0.2958,-0.717,0.819,873,1,"regorafenib, mubritinib, BMS.599626, cabozantinib, tyrphostin.A9, UNC2250, tivantinib, sunitinib, aminopurvalanol.a, NVP.TAE226",0.0867160982395816,0,FALSE +"H460","Pearson.est","VEGFR inhibitor",-0.2665,-0.644,0.92,817,1,"dovitinib, MK.2461, regorafenib, semaxanib, PD.173074, cabozantinib, SU014813, SAR131675, OSI.930, sunitinib, RAF265, vatalanib, TG.100572, ENMD.2076, KI.8751",0.0362121726544447,0,FALSE +"H460","Pearson.est","vitamin D receptor agonist",-0.35484,-0.852,0.677,847,1,"alfacalcidol, doxercalciferol, tacalcitol, ercalcitriol",0.169411331314856,0,FALSE +"H1299","Pearson.est","EGFR inhibitor",0.8326,2.35,0,121,0.0105,"AZD8931, poziotinib, XL.647, canertinib, neratinib, gefitinib, lapatinib, BMS.690514, dacomitinib, osimertinib, erlotinib, tucatinib, ARRY.334543, afatinib, vandetanib, BMS.599626, PD.168393, CUDC.101, icotinib, WZ8040, AST.1306, pelitinib, BIBU.1361, PD.153035, CP.724714, AEE788, rociletinib, WZ.4002, GW.583340",Inf,1.97881070093006,TRUE +"H1299","Pearson.est","Abl kinase inhibitor",-0.32189,-0.752,0.804,998,1,"ponatinib, flumatinib, nilotinib, KW.2449, tozasertib, GZD824",0.0947439512515487,0,FALSE +"H1299","Pearson.est","acetylcholine receptor agonist",-0.4728,-1.12,0.317,1189,0.73,"xanomeline, oxiracetam",0.498940737782249,0.136677139879544,FALSE +"H1299","Pearson.est","acetylcholine receptor antagonist",-0.4804,-1.12,0.329,1151,0.73,"methscopolamine, iododexetimide",0.482804102050026,0.136677139879544,FALSE +"H1299","Pearson.est","adenosine receptor antagonist",0.64509,1.76,0.00909,122,0.156,"CGS.15943, MRS.1220, SCH.58261, PSB.1115",2.04143611677803,0.806875401645538,TRUE +"H1299","Pearson.est","adrenergic receptor agonist",0.2568,0.734,0.824,1080,1,"isoxsuprine, methyldopa, oxymetazoline, isoetharine, ritodrine, norepinephrine, metaraminol, epinephrine, terbutaline, xylazine, A61603, clenbuterol, buphenine, lidamidine, midodrine",0.0840727883028842,0,FALSE +"H1299","Pearson.est","adrenergic receptor antagonist",-0.34419,-0.799,0.735,868,1,"pindolol, naftidrofuryl, metoprolol, oxprenolol, atipamezole, vincamine, idazoxan, carvedilol",0.133712660915805,0,FALSE +"H1299","Pearson.est","AKT inhibitor",0.46108,1.34,0.146,243,0.356,"GDC.0068, uprosertib, CCT128930, GSK2110183, AZD5363, triciribine",0.835647144215563,0.448550002027125,FALSE +"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.26514,0.741,0.796,1067,1,"GW.788388, brigatinib, SB.505124, NVP.TAE684, CEP.37440, alectinib, AP26113, AZD3463, crizotinib, DMH1, lorlatinib",0.0990869322623309,0,FALSE +"H1299","Pearson.est","androgen receptor antagonist",-0.26972,-0.638,0.913,551,0.952,"cyproterone.acetate, RU.58841, bicalutamide, flutamide, nilutamide",0.039529222465701,0.0213630516155257,FALSE +"H1299","Pearson.est","antioxidant",0.53883,1.49,0.0708,671,0.301,"mesna, taurine, trolox, rutin, chlorogenic.acid, benfotiamine",1.14996674231023,0.521433504406157,FALSE +"H1299","Pearson.est","AP inhibitor",-0.51716,-1.22,0.224,1012,0.668,"birinapant, GDC.0152, idronoxil",0.649751981665837,0.175223537524454,FALSE +"H1299","Pearson.est","ATPase inhibitor",-0.71887,-1.69,0.0193,1165,0.122,"evodiamine, digitoxin, ouabain, k.strophanthidin, thonzonium, NMS.873, digitoxigenin, oligomycin.a, digoxin",1.71444269099223,0.913640169325252,TRUE +"H1299","Pearson.est","Aurora kinase inhibitor",-0.64737,-1.55,0.0259,1167,0.31,"ZM.447439, GSK1070916, alisertib, KW.2449, tozasertib, MK.8745, barasertib.HQPA, hesperadin, CCT137690, AT.9283, barasertib, PF.03814735, MK.5108, AMG900, SNS.314, danusertib",1.58670023591875,0.508638306165727,FALSE +"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.30244,-0.703,0.847,940,0.993,"josamycin, radezolid, valnemulin",0.0721165896692931,0.00305075150461883,FALSE +"H1299","Pearson.est","bacterial DNA gyrase inhibitor",-0.31494,-0.749,0.783,702,1,"sparfloxacin, trovafloxacin, sarafloxacin, norfloxacin, lomefloxacin, novobiocin",0.106238237942057,0,FALSE +"H1299","Pearson.est","BCL inhibitor",-0.4493,-1.05,0.419,1229,0.861,"TW.37, gossypol",0.377785977033705,0.0649968485463452,FALSE +"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.37134,-0.875,0.653,998,1,"ponatinib, flumatinib, nilotinib, tozasertib, GZD824",0.185086818724926,0,FALSE +"H1299","Pearson.est","benzodiazepine receptor agonist",0.22997,0.661,0.859,1118,1,"CL.218872, gamma.aminobutyric.acid, nefiracetam, piperazine, eprinomectin, lorazepam, zaleplon, bentazepam, CGS.20625, indiplon, ZK.93423, ivermectin, temazepam",0.0660068361687577,0,FALSE +"H1299","Pearson.est","bromodomain inhibitor",-0.3536,-0.825,0.688,634,1,"I.BET151, OTX015, PFI.1, bromosporine",0.162411561764489,0,FALSE +"H1299","Pearson.est","calcium channel blocker",-0.33053,-0.765,0.746,1423,1,"carboxyamidotriazole",0.127261172527331,0,FALSE +"H1299","Pearson.est","CC chemokine receptor antagonist",-0.60278,-1.4,0.0927,913,0.507,"RS.504393, PF.04136309, MK.0812, SB.225002, UNBS.5162",1.0329202658555,0.294992040666664,FALSE +"H1299","Pearson.est","CDK inhibitor",-0.33829,-0.795,0.743,880,1,"JNJ.7706621, AZD5438, kenpaullone, palbociclib, dinaciclib, R547, PHA.848125, BMS.265246, BMS.387032, indisulam, abemaciclib, PHA.793887",0.129011186239425,0,FALSE +"H1299","Pearson.est","CHK inhibitor",-0.43828,-1.03,0.442,1191,0.884,"LY2606368, PF.477736",0.354577730650908,0.0535477349869269,FALSE +"H1299","Pearson.est","cyclooxygenase inhibitor",-0.30549,-0.725,0.813,1096,1,"indoprofen, piroxicam, AM.404, naproxen, suxibuzone, tepoxalin",0.0899094544059319,0,FALSE +"H1299","Pearson.est","cytochrome P450 inhibitor",-0.38331,-0.895,0.613,929,1,"clotrimazole, cobicistat, metyrapone",0.212539525481585,0,FALSE +"H1299","Pearson.est","DNA alkylating agent",-0.38587,-0.904,0.615,904,1,"streptozotocin, estramustine, cisplatin, carboplatin, TH.302, dianhydrogalactitol, satraplatin, melphalan",0.211124884224583,0,FALSE +"H1299","Pearson.est","DNA inhibitor",-0.38573,-0.908,0.577,1338,1,"valrubicin, melphalan, chlorambucil",0.238824186844269,0,FALSE +"H1299","Pearson.est","DNA methyltransferase inhibitor",0.24649,0.701,0.825,184,1,"azacitidine, fdcyd",0.0835460514500749,0,FALSE +"H1299","Pearson.est","DNA polymerase inhibitor",-0.41626,-0.965,0.52,1159,1,"trifluridine, idoxuridine, cephalomannine",0.283996656365201,0,FALSE +"H1299","Pearson.est","DNA synthesis inhibitor",-0.52826,-1.22,0.215,981,0.668,"nelarabine, azodicarbonamide, cyclocytidine, artesunate, enocitabine, cisplatin, CB.10.277, artemisinin, anisomycin",0.667561540084395,0.175223537524454,FALSE +"H1299","Pearson.est","dopamine receptor antagonist",0.21578,0.617,0.916,264,1,"lurasidone, clebopride, domperidone, ziprasidone, remoxipride, acetophenazine, nemonapride, mesoridazine, oxiperomide",0.0381045263321496,0,FALSE +"H1299","Pearson.est","estrogen receptor agonist",0.29792,0.83,0.668,1019,1,"levonorgestrel, erteberel, ethinyl.estradiol, equol, estradiol.cypionate, PPT, estradiol, estrone",0.175223537524454,0,FALSE +"H1299","Pearson.est","estrogen receptor antagonist",-0.39952,-0.941,0.537,1139,1,"fulvestrant, toremifene",0.270025714300444,0,FALSE +"H1299","Pearson.est","FGFR inhibitor",-0.50765,-1.19,0.246,1048,0.69,"MK.2461, dovitinib, nintedanib, erdafitinib, regorafenib",0.609064892896621,0.161150909262745,FALSE +"H1299","Pearson.est","FLT3 inhibitor",-0.49502,-1.17,0.272,998,0.715,"ponatinib, lestaurtinib, TG.101348, dovitinib, KW.2449, tyrphostin.AG.1296, tozasertib, midostaurin, quizartinib, sorafenib",0.565431095965801,0.145693958198919,FALSE +"H1299","Pearson.est","glucocorticoid receptor agonist",0.15179,0.417,0.991,1232,0.998,"triamcinolone.acetonide, ciclesonide, fludroxycortide, hydrocortisone, desonide, methylprednisolone, betamethasone, difluprednate, flumethasone.pivalate, dexamethasone.acetate, fluocinolone.acetonide, clobetasol.propionate, flumethasone, piretanide, prednisolone.acetate, triamcinolone, halobetasol.propionate, halcinonide, prednisolone, prednisolone.hemisuccinate, beclomethasone.dipropionate, rimexolone, deflazacort, fluticasone.propionate, fluorometholone",0.00392634551472468,0.000869458712628891,FALSE +"H1299","Pearson.est","glutamate receptor antagonist",0.42771,1.21,0.204,164,0.488,"diazooxonorleucine, latrepirdine, CGP.37849, kynurenic.acid, SIB.1757",0.690369832574101,0.311580177997289,FALSE +"H1299","Pearson.est","glycogen synthase kinase inhibitor",-0.27844,-0.66,0.882,926,0.983,"GSK.3.inhibitor.IX, TWS.119, kenpaullone, AZD2858, tideglusib",0.0545314148681803,0.00744648216786438,FALSE +"H1299","Pearson.est","growth factor receptor inhibitor",-0.36841,-0.873,0.649,927,1,"GSK1838705A, PHA.848125, lestaurtinib, danusertib",0.187755303199631,0,FALSE +"H1299","Pearson.est","HCV inhibitor",-0.65176,-1.53,0.0424,1138,0.314,"Ro.9187, mericitabine, narlaprevir",1.37263414340727,0.503070351926785,FALSE +"H1299","Pearson.est","HDAC inhibitor",-0.30694,-0.727,0.814,760,1,"R306465, ACY.1215, SB.939, trichostatin.a, givinostat, RG2833, AR.42, resminostat, scriptaid, chidamide, dacinostat, entinostat, belinostat",0.0893755951107988,0,FALSE +"H1299","Pearson.est","histamine receptor antagonist",-0.21575,-0.51,0.976,1180,0.994,"nizatidine, tiotidine, cimetidine",0.0105501823333082,0.00261361560268669,FALSE +"H1299","Pearson.est","HMGCR inhibitor",-0.84377,-2,0.00124,1408,0.0212,"pitavastatin, fluvastatin, mevastatin, atorvastatin",2.90657831483776,1.67366413907125,TRUE +"H1299","Pearson.est","HSP inhibitor",-0.64908,-1.52,0.052,1247,0.3,"BIIB021, PU.H71, ganetespib, SNX.2112, NVP.AUY922, NMS.E973",1.2839966563652,0.522878745280338,FALSE +"H1299","Pearson.est","JAK inhibitor",-0.36124,-0.849,0.67,1039,1,"lestaurtinib, TG.101348, AZ960, PRT062070, tozasertib, AT.9283",0.173925197299174,0,FALSE +"H1299","Pearson.est","KIT inhibitor",-0.5337,-1.25,0.191,1107,0.656,"cediranib, OSI.930, motesanib, vatalanib, midostaurin, sorafenib, KI.8751, regorafenib, pazopanib",0.718966632752272,0.18309616062434,FALSE +"H1299","Pearson.est","MDM inhibitor",-0.28205,-0.657,0.882,1222,0.968,"serdemetan",0.0545314148681803,0.0141246426916063,FALSE +"H1299","Pearson.est","MEK inhibitor",0.66475,2.05,0.00518,168,0.0514,"trametinib, AS.703026, selumetinib, cobimetinib, AZD8330, PD.0325901, TAK.733, Ro.4987655, MEK162, PD.318088, PD.198306, MEK1.2.inhibitor",2.28567024025477,1.28903688100472,TRUE +"H1299","Pearson.est","MET inhibitor",-0.2762,-0.647,0.903,955,0.96,"AMG458, PHA.665752, LY2801653",0.0443122496864942,0.0177287669604316,FALSE +"H1299","Pearson.est","microtubule inhibitor",-0.72772,-1.7,0.00855,1273,0.133,"D.64131, podophyllotoxin, secnidazole, cabazitaxel, vinflunine, vinblastine",2.06803388527183,0.876148359032914,TRUE +"H1299","Pearson.est","mTOR inhibitor",0.16318,0.456,1,1022,1,"GSK2126458, GDC.0980, LY303511, WYE.125132, voxtalisib, WAY.600, PP242, XL388, PI.103, OSI.027, torin.2, PF.04691502, SB.2343, everolimus, WYE.354, palomid.529, AZD2014, torin.1, AZD8055, temsirolimus, PF.05212384, MLN0128, NVP.BEZ235, ku.0063794, sirolimus, PKI.179, LY3023414",0,0,FALSE +"H1299","Pearson.est","NFkB pathway inhibitor",-0.32517,-0.773,0.786,613,1,"curcumin, parthenolide...., bindarit, BAY.11.7082, betulinic.acid, bortezomib, parthenolide, IKK.2.inhibitor.V, EVP4593",0.104577453960592,0,FALSE +"H1299","Pearson.est","opioid receptor agonist",-0.39109,-0.916,0.587,754,1,"salvinorin.a, trimebutine, cebranopadol, spiradoline",0.231361898752386,0,FALSE +"H1299","Pearson.est","p38 MAPK inhibitor",0.47606,1.39,0.0878,762,0.328,"SB.239063, talmapimod, SB.242235, TAK.715, skepinone.l, VX.702, CMPD.1",1.0565054840939,0.484126156288321,FALSE +"H1299","Pearson.est","PARP inhibitor",-0.49206,-1.15,0.303,728,0.707,"PJ.34, niraparib, AG.14361, E7449, olaparib, AZD2461, talazoparib",0.518557371497695,0.150580586203101,FALSE +"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.55223,-1.3,0.145,1131,0.588,"trapidil, motesanib, SU014813, dovitinib, nintedanib, vatalanib, axitinib, crenolanib, CP.673451, sorafenib, KI.8751, regorafenib, pazopanib",0.838631997765025,0.230622673923862,FALSE +"H1299","Pearson.est","phosphatase inhibitor",-0.40347,-0.925,0.587,935,1,"AS.1949490, BVT.948, CID.5458317, GSK2830371, bis.maltolato.oxovanadium.IV.",0.231361898752386,0,FALSE +"H1299","Pearson.est","phosphodiesterase inhibitor",-0.28672,-0.68,0.864,962,0.982,"papaverine, zardaverine, YM.976, GSK256066",0.0634862575211067,0.00788851221305034,FALSE +"H1299","Pearson.est","PI3K inhibitor",0.32666,0.883,0.553,92,1,"alpelisib, taselisib, GSK2126458, CH5132799, PI.828",0.257274868695302,0,FALSE +"H1299","Pearson.est","PLK inhibitor",-0.81124,-1.88,0.00124,1169,0.0515,"GW.843682X, HMN.214, GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib",2.90657831483776,1.28819277095881,TRUE +"H1299","Pearson.est","potassium channel blocker",-0.50625,-1.19,0.245,850,0.69,"ibutilide, meglitinide, mepivacaine, dofetilide",0.610833915635468,0.161150909262745,FALSE +"H1299","Pearson.est","PPAR receptor agonist",-0.35854,-0.833,0.71,809,1,"ciprofibrate, clofibrate, GW.501516",0.148741651280925,0,FALSE +"H1299","Pearson.est","progesterone receptor agonist",-0.18348,-0.435,0.994,799,0.994,"norgestrel, norethindrone, dienogest, tanaproget",0.00261361560268669,0.00261361560268669,FALSE +"H1299","Pearson.est","proteasome inhibitor",-0.59536,-1.38,0.0978,967,0.522,"bortezomib, ONX.0914, delanzomib, carfilzomib, ixazomib, MG.132",1.0096611452124,0.282329496997738,FALSE +"H1299","Pearson.est","protein synthesis inhibitor",-0.56802,-1.34,0.131,1206,0.515,"puromycin, cycloheximide, bruceantin, thiostrepton, harringtonine, mercaptopurine, homoharringtonine, anguidine",0.882728704344236,0.288192770958809,FALSE +"H1299","Pearson.est","protein tyrosine kinase inhibitor",0.42594,1.19,0.219,72,0.473,"BMS.599626, AV.412, CP.724714",0.659555885159882,0.325138859262188,FALSE +"H1299","Pearson.est","RAF inhibitor",-0.58449,-1.37,0.116,1250,0.508,"TAK.632, PLX.4720, RAF265, sorafenib, regorafenib",0.935542010773082,0.294136287716081,FALSE +"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.45537,-1.06,0.406,1345,0.866,"sorafenib, regorafenib",0.391473966422806,0.0624821079826534,FALSE +"H1299","Pearson.est","retinoid receptor agonist",0.31621,0.873,0.607,61,1,"CD.437, tamibarotene",0.216811308924742,0,FALSE +"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.59692,-1.41,0.0929,1302,0.527,"triapine, pentostatin, gemcitabine, cladribine, clofarabine",1.03198428600636,0.278189384787453,FALSE +"H1299","Pearson.est","serotonin receptor agonist",-0.55047,-1.28,0.185,1305,0.609,"pardoprunox, aripiprazole",0.732828271596986,0.215382707367125,FALSE +"H1299","Pearson.est","serotonin receptor antagonist",-0.49817,-1.16,0.289,1316,0.71,"paliperidone, lerisetron, aripiprazole",0.539102157243452,0.148741651280925,FALSE +"H1299","Pearson.est","sodium channel blocker",-0.5799,-1.36,0.138,971,0.496,"quinidine, mepivacaine, butamben, brivaracetam, triamterene, cibenzoline, benzethonium",0.860120913598763,0.304518323509803,FALSE +"H1299","Pearson.est","src inhibitor",0.62004,1.74,0.0249,41,0.134,"saracatinib, dasatinib, ZM.306416",1.60380065290426,0.872895201635192,TRUE +"H1299","Pearson.est","sterol demethylase inhibitor",-0.30205,-0.712,0.834,738,1,"lanoconazole, ketoconazole, posaconazole, chlormidazole",0.0788339493622613,0,FALSE +"H1299","Pearson.est","TGF beta receptor inhibitor",0.51299,1.43,0.0931,227,0.317,"repsox, LY2109761, SB.431542",1.03105031901866,0.498940737782249,FALSE +"H1299","Pearson.est","thymidylate synthase inhibitor",-0.27336,-0.636,0.894,664,0.937,"ftorafur, doxifluridine, raltitrexed, trifluridine",0.0486624812040823,0.0282604091122217,FALSE +"H1299","Pearson.est","topoisomerase inhibitor",-0.79476,-1.84,0.0025,1234,0.05,"genz.644282, amonafide, dexrazoxane, amsacrine, SN.38, nemorubicin, valrubicin, idarubicin, irinotecan, mitoxantrone, voreloxin, doxorubicin, epirubicin, TAS.103, rubitecan, etoposide, etoposide.phosphate, daunorubicin, teniposide, topotecan",2.60205999132796,1.30102999566398,TRUE +"H1299","Pearson.est","tubulin polymerization inhibitor",-0.77033,-1.82,0.00854,1175,0.0513,"parbendazole, mebendazole, epothilone.d, epothilone.b, albendazole, fenbendazole, plinabulin, fosbretabulin, ABT.751, dolastatin.10, podophyllotoxin, vinorelbine, KX2.391, CYT.997, paclitaxel, docetaxel, combretastatin.A.4, vincristine, vindesine, verubulin, taltobulin, BNC105, vinblastine",2.068542129311,1.28988263488818,TRUE +"H1299","Pearson.est","tyrosine kinase inhibitor",0.26174,0.74,0.807,72,1,"vandetanib, BMS.599626, dasatinib, AV.412, CP.724714",0.0931264652779296,0,FALSE +"H1299","Pearson.est","VEGFR inhibitor",-0.2861,-0.682,0.869,1048,0.998,"MK.2461, SAR131675, cediranib, OSI.930, motesanib, SU014813, dovitinib, nintedanib, vatalanib, tivozanib, axitinib, RAF265, sorafenib, KI.8751, regorafenib, pazopanib",0.0609802235513335,0.000869458712628891,FALSE +"H1299","Pearson.est","vitamin D receptor agonist",0.73963,2.15,0,144,0.0363,"maxacalcitol, paricalcitol, tacalcitol",Inf,1.44009337496389,TRUE +"HCC44","Pearson.est","EGFR inhibitor",-0.74153,-1.74,0.00917,1369,0.257,"WZ.4002, PD.168393, BMS.690514, BMS.599626, CUDC.101, icotinib, BIBU.1361, vandetanib, canertinib, lapatinib, PD.153035, osimertinib, neratinib, AST.1306, AZD8931, dacomitinib, pelitinib, gefitinib, afatinib, erlotinib, XL.647, poziotinib",2.03763066432998,0.590066876668705,FALSE +"HCC44","Pearson.est","Abl kinase inhibitor",-0.60626,-1.4,0.106,1396,0.58,"ZM.306416, bosutinib, dasatinib",0.97469413473523,0.236572006437063,FALSE +"HCC44","Pearson.est","acetylcholine receptor agonist",0.19626,0.54,0.956,1165,0.971,"nefiracetam, xanomeline, oxiracetam, nicotine, tremorine, pilocarpine",0.0195421077238999,0.0127807700919951,FALSE +"HCC44","Pearson.est","acetylcholine receptor antagonist",0.51275,1.45,0.0855,347,0.906,"diphemanil, iododexetimide, darifenacin, methscopolamine",1.06803388527183,0.0428718023231869,FALSE +"HCC44","Pearson.est","adenosine receptor antagonist",-0.63517,-1.49,0.0571,1352,0.582,"PSB.1115, CGS.15943",1.24336389175415,0.235077015350112,FALSE +"HCC44","Pearson.est","adrenergic receptor agonist",-0.29171,-0.672,0.874,1217,1,"isoxsuprine, ritodrine, oxymetazoline",0.058488567365597,0,FALSE +"HCC44","Pearson.est","adrenergic receptor antagonist",-0.21931,-0.515,0.965,922,1,"atenolol......, idazoxan, vincamine, atipamezole, naftidrofuryl, imiloxan, dronedarone",0.0154726866562074,0,FALSE +"HCC44","Pearson.est","AKT inhibitor",-0.41692,-0.962,0.515,953,0.893,"palomid.529, uprosertib, AZD5363, AT7867, triciribine",0.288192770958809,0.0491485411114536,FALSE +"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.37021,-0.86,0.668,822,1,"alectinib, lorlatinib, SB.505124, GW.788388, AP26113, AZD3463",0.175223537524454,0,FALSE +"HCC44","Pearson.est","androgen receptor antagonist",0.24856,0.711,0.824,237,1,"flutamide, enzalutamide",0.0840727883028842,0,FALSE +"HCC44","Pearson.est","antioxidant",-0.5485,-1.28,0.191,1398,0.542,"mesna",0.718966632752272,0.266000713461613,FALSE +"HCC44","Pearson.est","AP inhibitor",0.25515,0.725,0.811,68,1,"idronoxil",0.090979145788844,0,FALSE +"HCC44","Pearson.est","ATPase inhibitor",0.32566,0.894,0.546,183,1,"oligomycin.a, omeprazole, rabeprazole",0.262807357295263,0,FALSE +"HCC44","Pearson.est","Aurora kinase inhibitor",-0.31183,-0.716,0.815,968,1,"hesperadin, CCT129202, MK.5108, danusertib, ENMD.2076, alisertib, CYC116, PHA.680632, GSK1070916",0.0888423912600234,0,FALSE +"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.58114,-1.36,0.124,912,0.647,"dirithromycin, azalomycin.b, azithromycin, tilmicosin, radezolid, valnemulin, tedizolid",0.906578314837765,0.1890957193313,FALSE +"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.45392,-1.08,0.358,1422,0.885,"finafloxacin",0.446116973356126,0.0530567293021746,FALSE +"HCC44","Pearson.est","BCL inhibitor",0.39765,1.09,0.286,116,0.836,"oridonin, ABT.737, HA14.1",0.543633966870957,0.0777937225609836,FALSE +"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.55572,-1.31,0.137,1407,0.561,"bosutinib, dasatinib",0.863279432843593,0.251037138743839,FALSE +"HCC44","Pearson.est","benzodiazepine receptor agonist",-0.23279,-0.544,0.957,961,1,"CGS.20625, zaleplon, ZK.93423, eprinomectin, lorazepam, ivermectin",0.0190880622231565,0,FALSE +"HCC44","Pearson.est","bromodomain inhibitor",0.30236,0.855,0.61,1012,0.99,"PFI.1, I.BET151, OTX015, I.BET.762, bromosporine, JQ1....",0.214670164989233,0.00436480540245009,FALSE +"HCC44","Pearson.est","calcium channel blocker",-0.44882,-1.06,0.389,1228,0.901,"SKF.96365, cinnarazine, tetrandrine",0.410050398674292,0.045275209020937,FALSE +"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.43962,-1.02,0.426,1337,0.903,"navarixin, ZK811752",0.370590400897281,0.0443122496864942,FALSE +"HCC44","Pearson.est","CDK inhibitor",-0.57439,-1.33,0.149,1116,0.547,"BMS.387032, kenpaullone, palbociclib, PHA.848125, P276.00, BMS.265246, JNJ.7706621, aminopurvalanol.a, AT.7519, alvocidib, AZD5438",0.826813731587726,0.262012673666569,FALSE +"HCC44","Pearson.est","CHK inhibitor",0.23084,0.64,0.91,62,0.971,"PF.477736",0.0409586076789064,0.0127807700919951,FALSE +"HCC44","Pearson.est","cyclooxygenase inhibitor",0.30121,0.84,0.602,101,0.964,"naproxen, AM.404, sulfasalazine, metoxibutropate, suxibuzone",0.220403508742175,0.0159229660971692,FALSE +"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.48228,-1.13,0.308,1082,0.821,"morin, eplerenone, itraconazole",0.511449283499556,0.0856568428805592,FALSE +"HCC44","Pearson.est","DNA alkylating agent",-0.25409,-0.594,0.921,959,1,"estramustine, streptozotocin, dacarbazine, temozolomide, cyclophosphamide, carmustine",0.0357403698031511,0,FALSE +"HCC44","Pearson.est","DNA inhibitor",-0.22682,-0.528,0.971,849,1,"primaquine, busulfan, nimorazole, oxaliplatin, teroxirone, metronidazole, sangivamycin, carmustine",0.0127807700919951,0,FALSE +"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.57187,-1.33,0.146,1309,0.547,"azacitidine, decitabine",0.835647144215563,0.262012673666569,FALSE +"HCC44","Pearson.est","DNA polymerase inhibitor",-0.53296,-1.27,0.182,1032,0.535,"foscarnet, cidofovir, trifluridine, adefovir.dipivoxil, idoxuridine",0.739928612014925,0.271646217978772,FALSE +"HCC44","Pearson.est","DNA synthesis inhibitor",-0.27393,-0.641,0.89,1149,1,"capecitabine, cyclocytidine, CB.10.277, anisomycin",0.0506099933550872,0,FALSE +"HCC44","Pearson.est","dopamine receptor antagonist",-0.44209,-1.03,0.451,1063,0.911,"piperacetazine, UH.232...., domperidone, clebopride, oxiperomide, acetophenazine, mesoridazine",0.345823458122039,0.0404816230270017,FALSE +"HCC44","Pearson.est","estrogen receptor agonist",-0.24876,-0.587,0.936,948,1,"ethinyl.estradiol, estrone, PPT, erteberel",0.0287241512618947,0,FALSE +"HCC44","Pearson.est","estrogen receptor antagonist",0.33989,0.929,0.516,158,1,"toremifene, danazol",0.287350298372789,0,FALSE +"HCC44","Pearson.est","FGFR inhibitor",0.4823,1.34,0.148,284,0.788,"erdafitinib, nintedanib, lenvatinib, dovitinib, orantinib, regorafenib",0.829738284605043,0.103473782510445,FALSE +"HCC44","Pearson.est","FLT3 inhibitor",-0.21355,-0.498,0.98,893,0.997,"TG.02, GTP.14564, tandutinib, ENMD.2076, pacritinib, gilteritinib",0.00877392430750515,0.00130484168834428,FALSE +"HCC44","Pearson.est","glucocorticoid receptor agonist",-0.66066,-1.53,0.0501,1182,0.549,"difluprednate, prednisolone.acetate, halcinonide, rimexolone, dexamethasone.acetate, flumethasone.pivalate, flumethasone, methylprednisolone, desonide, halobetasol.propionate, triamcinolone.acetonide, ciclesonide, fluocinolone.acetonide, hydrocortisone",1.30016227413275,0.260427655549908,FALSE +"HCC44","Pearson.est","glutamate receptor antagonist",-0.27592,-0.636,0.873,1249,1,"diazooxonorleucine, SIB.1757",0.0589857562944303,0,FALSE +"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.26783,-0.62,0.909,1089,1,"TWS.119, kenpaullone, LY2090314",0.0414361167780325,0,FALSE +"HCC44","Pearson.est","growth factor receptor inhibitor",-0.57476,-1.35,0.139,1015,0.623,"danusertib, GSK1838705A, PHA.848125, AZD3463, GSK1904529A",0.856985199745905,0.20551195334083,FALSE +"HCC44","Pearson.est","HCV inhibitor",-0.36096,-0.851,0.67,1109,1,"embelin, PSI.7976",0.173925197299174,0,FALSE +"HCC44","Pearson.est","HDAC inhibitor",0.31392,0.886,0.553,224,0.977,"mocetinostat, pyroxamide, vorinostat, ACY.1215, scriptaid, chidamide, resminostat, M.344",0.257274868695302,0.0101054362812269,FALSE +"HCC44","Pearson.est","histamine receptor antagonist",-0.41138,-0.953,0.519,1020,0.886,"zolantidine, pheniramine, levocetirizine, ebastine, terfenadine, ranitidine, astemizole",0.284832642151542,0.0525662781129492,FALSE +"HCC44","Pearson.est","HMGCR inhibitor",0.75935,2.11,0.00858,60,0.132,"mevastatin, pitavastatin, atorvastatin",2.06651271215129,0.87942606879415,TRUE +"HCC44","Pearson.est","HSP inhibitor",-0.4145,-0.969,0.523,904,0.905,"tanespimycin, XL888, ganetespib, NVP.AUY922, SNX.2112, SNX.5422, PU.H71, BIIB021",0.281498311132726,0.0433514207947967,FALSE +"HCC44","Pearson.est","JAK inhibitor",-0.33483,-0.787,0.741,871,1,"baricitinib, atiprimod, TG.02, AZ960, CEP.33779, AZD1480, TG.101209, pacritinib, WHI.P154, filgotinib",0.130181792020672,0,FALSE +"HCC44","Pearson.est","KIT inhibitor",-0.25412,-0.601,0.92,1436,1,"dasatinib",0.0362121726544447,0,FALSE +"HCC44","Pearson.est","MDM inhibitor",0.26283,0.768,0.715,1069,1,"AMG.232, serdemetan, CGM097, idasanutlin, nutlin.3, RITA",0.145693958198919,0,FALSE +"HCC44","Pearson.est","MEK inhibitor",-0.77406,-1.8,0.00785,1295,0.295,"PD.184352, MEK162, refametinib, PD.318088, selumetinib, cobimetinib, Ro.4987655, AS.703026, PD.0325901, TAK.733, trametinib, AZD8330",2.10513034325475,0.530177984021837,FALSE +"HCC44","Pearson.est","MET inhibitor",-0.36281,-0.844,0.671,992,1,"PHA.665752, LY2801653, PF.04217903",0.173277479831008,0,FALSE +"HCC44","Pearson.est","microtubule inhibitor",-0.27379,-0.641,0.886,954,1,"D.64131, cabazitaxel, vinblastine, cytochalasin.b, podophyllotoxin",0.0525662781129492,0,FALSE +"HCC44","Pearson.est","mTOR inhibitor",-0.39847,-0.932,0.566,1069,0.906,"voxtalisib, torin.1, PF.04691502, LY303511, OSI.027, AZD8055, PP242, XL388, WAY.600, WYE.354, GSK2126458",0.247183568811729,0.0428718023231869,FALSE +"HCC44","Pearson.est","NFkB pathway inhibitor",-0.18799,-0.439,0.986,900,0.993,"EVP4593, bortezomib, curcumin, BAY.11.7085, betulinic.acid",0.0061230850587888,0.00305075150461883,FALSE +"HCC44","Pearson.est","opioid receptor agonist",-0.42135,-0.995,0.494,652,0.904,"spiradoline, ADL5859, salvinorin.a, cebranopadol, trimebutine",0.306273051076353,0.0438315695246367,FALSE +"HCC44","Pearson.est","p38 MAPK inhibitor",-0.55789,-1.29,0.174,809,0.547,"SB.242235, skepinone.l, VX.702, SB.239063, CMPD.1, TAK.715",0.7594507517174,0.262012673666569,FALSE +"HCC44","Pearson.est","PARP inhibitor",0.2542,0.687,0.85,342,0.953,"AZD2461, olaparib, talazoparib, PJ.34",0.0705810742857073,0.0209070993616736,FALSE +"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.33372,0.915,0.538,290,1,"nintedanib, lenvatinib, pazopanib, linifanib, motesanib, axitinib, dovitinib, trapidil, orantinib, sorafenib, regorafenib, telatinib",0.269217724333611,0,FALSE +"HCC44","Pearson.est","phosphatase inhibitor",0.35989,1,0.427,228,0.986,"bis.maltolato.oxovanadium.IV., BVT.948, menadione, CID.5458317",0.369572124974976,0.0061230850587888,FALSE +"HCC44","Pearson.est","phosphodiesterase inhibitor",0.2223,0.617,0.902,13,0.953,"enoximone",0.0447934624580583,0.0209070993616736,FALSE +"HCC44","Pearson.est","PI3K inhibitor",-0.47286,-1.11,0.324,941,0.84,"PIK.75, CH5132799, YM.201636, voxtalisib, PF.04691502, AZD6482, LY303511, buparlisib, taselisib, GDC.0941, alpelisib, TG.100713, GSK2126458",0.489454989793388,0.0757207139381184,FALSE +"HCC44","Pearson.est","PLK inhibitor",-0.45064,-1.05,0.377,772,0.892,"BI.2536, GSK461364, GW.843682X, rigosertib, NMS.1286937",0.423658649794207,0.0496351456238769,FALSE +"HCC44","Pearson.est","potassium channel blocker",0.25104,0.704,0.81,1086,0.97,"dofetilide, mepivacaine, meglitinide, ibutilide, ML133, oleoylethanolamide",0.0915149811213502,0.0132282657337552,FALSE +"HCC44","Pearson.est","PPAR receptor agonist",0.51969,1.48,0.0991,178,1,"GW.501516, clofibrate, pterostilbene",1.00392634551472,0,FALSE +"HCC44","Pearson.est","progesterone receptor agonist",0.49856,1.42,0.125,158,0.753,"norethindrone.acetate, norethindrone, norgestrel, danazol",0.903089986991944,0.123205023799299,FALSE +"HCC44","Pearson.est","proteasome inhibitor",0.41544,1.12,0.311,261,0.846,"delanzomib, ONX.0914, oprozomib, MG.132",0.507239610973163,0.0726296369609765,FALSE +"HCC44","Pearson.est","protein synthesis inhibitor",-0.33274,-0.78,0.747,786,1,"tedizolid.phosphate, florfenicol, chloramphenicol.palmitate, homoharringtonine, bruceantin, thiostrepton, emetine, cycloheximide, brefeldin.a",0.126679398184601,0,FALSE +"HCC44","Pearson.est","protein tyrosine kinase inhibitor",-0.56854,-1.34,0.148,1374,0.603,"NVP.TAE226, BMS.599626, AV.412",0.829738284605043,0.219682687859849,FALSE +"HCC44","Pearson.est","RAF inhibitor",-0.31407,-0.741,0.806,1014,1,"LGX818, CEP.32496, SB.590885, AZ.628",0.0936649581949093,0,FALSE +"HCC44","Pearson.est","RET tyrosine kinase inhibitor",-0.6037,-1.41,0.109,1418,0.787,"vandetanib",0.962573502059376,0.104025267640935,FALSE +"HCC44","Pearson.est","retinoid receptor agonist",0.43741,1.25,0.189,149,0.86,"fenretinide, adapalene, LE.135, bexarotene",0.723538195826756,0.0655015487564323,FALSE +"HCC44","Pearson.est","ribonucleotide reductase inhibitor",0.44038,1.21,0.22,250,0.831,"pentostatin, cladribine, hydroxyurea, fludarabine",0.657577319177794,0.080398976215889,FALSE +"HCC44","Pearson.est","serotonin receptor agonist",-0.42138,-0.993,0.484,1286,0.879,"ipsapirone",0.315154638355588,0.0560111249262281,FALSE +"HCC44","Pearson.est","serotonin receptor antagonist",-0.42529,-0.996,0.473,1072,0.932,"SB.216641, pirenperone, RS.16566, SB.228357",0.325138859262188,0.0305840876460186,FALSE +"HCC44","Pearson.est","sodium channel blocker",0.25567,0.716,0.803,25,1,"cibenzoline, oxcarbazepine",0.095284454721319,0,FALSE +"HCC44","Pearson.est","src inhibitor",-0.73033,-1.7,0.0117,1268,0.186,"PP.2, ZM.306416, bosutinib, saracatinib, dasatinib",1.93181413825384,0.730487055782084,TRUE +"HCC44","Pearson.est","sterol demethylase inhibitor",0.41401,1.18,0.242,259,0.796,"chlormidazole, ketoconazole, posaconazole",0.616184634019569,0.0990869322623309,FALSE +"HCC44","Pearson.est","TGF beta receptor inhibitor",-0.60439,-1.4,0.0913,1175,0.58,"D.4476, repsox",1.0395292224657,0.236572006437063,FALSE +"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.73496,-1.72,0.00789,1138,0.204,"trifluridine, capecitabine, ftorafur, raltitrexed, carmofur",2.10292299679058,0.690369832574101,TRUE +"HCC44","Pearson.est","topoisomerase inhibitor",-0.34027,-0.783,0.742,1124,1,"amsacrine, camptothecin, TAS.103, licochalcone.a, SN.38, idarubicin, exatecan.mesylate, fleroxacin",0.129596094720973,0,FALSE +"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.5069,-1.21,0.263,963,0.648,"vinblastine, dolastatin.10, vinorelbine, verubulin, plinabulin, paclitaxel, albendazole, oxibendazole, fosbretabulin, docetaxel, indibulin, podophyllotoxin, epothilone.b, parbendazole, nocodazole",0.580044251510242,0.188424994129407,FALSE +"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.55477,-1.29,0.175,1336,0.547,"aminopurvalanol.a, NVP.TAE226, tivantinib, BMS.599626, AV.412, vandetanib, dasatinib",0.756961951313706,0.262012673666569,FALSE +"HCC44","Pearson.est","VEGFR inhibitor",-0.30144,-0.71,0.83,1391,1,"BMS.690514, ZM.306416, vandetanib, XL.647",0.0809219076239261,0,FALSE +"HCC44","Pearson.est","vitamin D receptor agonist",-0.59072,-1.4,0.109,1126,0.58,"alfacalcidol, ercalcitriol, tacalcitol",0.962573502059376,0.236572006437063,FALSE +"A549","Pearson.est","EGFR inhibitor",-0.2672,-0.658,0.889,795,1,"ARRY.334543, tyrphostin.AG.494, CNX.2006, BMS.690514, dacomitinib, poziotinib, gefitinib, vandetanib, XL.647, afatinib, PD.153035, WZ8040, tyrphostin.AG.1478, pelitinib, PD.168393, erlotinib, OSI.420, icotinib, WZ.4002, BMS.599626",0.0510982390297863,0,FALSE +"A549","Pearson.est","Abl kinase inhibitor",-0.57696,-1.42,0.0984,1115,0.573,"KW.2449, flumatinib, GZD824, ponatinib, nilotinib, metatinib, bosutinib, dasatinib",1.00700490156866,0.24184537803261,FALSE +"A549","Pearson.est","acetylcholine receptor agonist",-0.24936,-0.616,0.911,672,1,"tremorine, nicotine, pilocarpine",0.0404816230270017,0,FALSE +"A549","Pearson.est","acetylcholine receptor antagonist",0.28502,0.834,0.658,1037,0.775,"diphemanil, iododexetimide, hyoscyamine, darifenacin, dicycloverine, methscopolamine",0.181774106386044,0.11069829749369,FALSE +"A549","Pearson.est","adenosine receptor antagonist",0.26509,0.825,0.677,1066,0.745,"MRS.1220, SCH.58261, istradefylline, CGS.15943, sulmazole, theophylline, PSB.1115",0.169411331314856,0.127843727251707,FALSE +"A549","Pearson.est","adrenergic receptor agonist",-0.31283,-0.759,0.774,1030,1,"oxymetazoline, isoetharine, midodrine, buphenine, clenbuterol, isoxsuprine",0.111259039317107,0,FALSE +"A549","Pearson.est","adrenergic receptor antagonist",-0.38915,-0.962,0.515,788,0.978,"prazosin, oxprenolol, RS.17053, carvedilol, pindolol, idazoxan, naftidrofuryl, dronedarone, imiloxan, vincamine, levobunolol, atipamezole",0.288192770958809,0.00966114521239857,FALSE +"A549","Pearson.est","AKT inhibitor",0.39772,1.21,0.214,110,0.471,"GDC.0068, uprosertib, GSK2110183, MK.2206",0.669586226650809,0.326979092871104,FALSE +"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.4207,-1.03,0.413,1444,0.95,"AZD3463",0.384049948343599,0.0222763947111523,FALSE +"A549","Pearson.est","androgen receptor antagonist",-0.77344,-1.89,0.0024,1389,0.147,"nilutamide, cyproterone.acetate, RU.58841",2.61978875828839,0.832682665251824,TRUE +"A549","Pearson.est","antioxidant",-0.59613,-1.47,0.0595,909,0.623,"taurine, chlorogenic.acid, mesna, trolox, rutin",1.22548303427145,0.20551195334083,FALSE +"A549","Pearson.est","AP inhibitor",0.53398,1.57,0.0391,678,0.187,"embelin, idronoxil, tanshinone.i, birinapant, GDC.0152, LCL.161",1.40782324260413,0.728158393463501,TRUE +"A549","Pearson.est","ATPase inhibitor",-0.5111,-1.26,0.201,1119,0.812,"digitoxin, digoxin, blebbistatin...., ouabain, digitoxigenin",0.696803942579511,0.0904439707588247,FALSE +"A549","Pearson.est","Aurora kinase inhibitor",-0.29338,-0.729,0.819,884,0.998,"MK.5108, hesperadin, SNS.314, alisertib, MLN.8054, KW.2449, CYC116, AT.9283, CCT129202, AMG900, PF.03814735",0.0867160982395816,0.000869458712628891,FALSE +"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.5828,-1.46,0.0896,1089,0.579,"tilmicosin, dirithromycin, valnemulin, radezolid, tedizolid",1.04769199033787,0.237321436272564,FALSE +"A549","Pearson.est","bacterial DNA gyrase inhibitor",-0.48335,-1.19,0.256,1433,0.849,"finafloxacin",0.59176003468815,0.0710923097560473,FALSE +"A549","Pearson.est","BCL inhibitor",0.27012,0.791,0.749,133,0.756,"ABT.737, oridonin, HA14.1",0.125518182300534,0.121478204498793,FALSE +"A549","Pearson.est","Bcr.Abl kinase inhibitor",-0.63302,-1.56,0.0375,1144,0.83,"flumatinib, GZD824, ponatinib, nilotinib, metatinib, bosutinib, dasatinib",1.42596873227228,0.0809219076239261,FALSE +"A549","Pearson.est","benzodiazepine receptor agonist",-0.3097,-0.761,0.781,1161,1,"lorazepam, CGS.20625, ivermectin, eprinomectin",0.1073489661227,0,FALSE +"A549","Pearson.est","bromodomain inhibitor",0.85058,2.55,0,190,0.00497,"I.BET151, OTX015, PFI.1, JQ1...., I.BET.762",Inf,2.30364361126667,TRUE +"A549","Pearson.est","calcium channel blocker",-0.20252,-0.499,0.988,1312,0.978,"cinnarazine",0.00524305541237188,0.00966114521239857,FALSE +"A549","Pearson.est","CC chemokine receptor antagonist",-0.39894,-0.992,0.494,1406,0.931,"navarixin",0.306273051076353,0.0310503190186574,FALSE +"A549","Pearson.est","CDK inhibitor",-0.54502,-1.35,0.122,1097,0.576,"CR8..R., NU6027, aminopurvalanol.a, JNJ.7706621, R547, abemaciclib, kenpaullone, PHA.848125, palbociclib, AZD5438, BMS.265246",0.913640169325252,0.239577516576788,FALSE +"A549","Pearson.est","CHK inhibitor",0.51839,1.55,0.0517,11,0.152,"PF.477736",1.28650945690606,0.818156412055227,FALSE +"A549","Pearson.est","cyclooxygenase inhibitor",-0.24007,-0.585,0.95,947,1,"piroxicam, meloxicam, acetylsalicylsalicylic.acid, tepoxalin, FR.122047, ketoprofen, indoprofen, tryptanthrin",0.0222763947111523,0,FALSE +"A549","Pearson.est","cytochrome P450 inhibitor",-0.58287,-1.44,0.078,934,0.574,"metyrapone, cobicistat, eplerenone, itraconazole",1.10790539730952,0.241088107602027,FALSE +"A549","Pearson.est","DNA alkylating agent",-0.44312,-1.1,0.352,764,0.964,"temozolomide, ifosfamide, dacarbazine, cyclophosphamide, melphalan, TH.302, carboplatin, carmustine, streptozotocin, mitomycin.c",0.453457336521869,0.0159229660971692,FALSE +"A549","Pearson.est","DNA inhibitor",-0.36606,-0.9,0.605,974,0.985,"melphalan, oxaliplatin, carboplatin, nimorazole, tirapazamine, valrubicin, carmustine, teroxirone",0.218244625347531,0.00656376950238827,FALSE +"A549","Pearson.est","DNA methyltransferase inhibitor",0.38071,1.16,0.245,23,0.498,"SGI.1027",0.610833915635468,0.302770657240282,FALSE +"A549","Pearson.est","DNA polymerase inhibitor",-0.30727,-0.757,0.774,1262,0.998,"idoxuridine, foscarnet",0.111259039317107,0.000869458712628891,FALSE +"A549","Pearson.est","DNA synthesis inhibitor",-0.54645,-1.35,0.149,1216,0.576,"CB.10.277, artesunate, floxuridine, mitomycin.c, cyclocytidine, anisomycin",0.826813731587726,0.239577516576788,FALSE +"A549","Pearson.est","dopamine receptor antagonist",-0.44472,-1.07,0.377,1145,0.938,"oxiperomide, amisulpride, piperacetazine, remoxipride, acetophenazine, mesoridazine, UH.232...., raclopride",0.423658649794207,0.0277971616209356,FALSE +"A549","Pearson.est","estrogen receptor agonist",-0.33536,-0.825,0.714,1156,1,"estradiol, estrone",0.146301788223826,0,FALSE +"A549","Pearson.est","estrogen receptor antagonist",0.68394,2.06,0.0166,1,0.072,"toremifene",1.77989191195995,1.14266750356873,TRUE +"A549","Pearson.est","FGFR inhibitor",-0.22677,-0.552,0.967,1381,0.972,"AZD4547",0.0145735259169983,0.0123337350737254,FALSE +"A549","Pearson.est","FLT3 inhibitor",-0.36625,-0.891,0.618,769,0.955,"pacritinib, ENMD.2076, gilteritinib, TG.101348, tandutinib, KW.2449, GTP.14564, ponatinib, midostaurin, quizartinib",0.209011524911184,0.0199966284162537,FALSE +"A549","Pearson.est","glucocorticoid receptor agonist",-0.55593,-1.37,0.134,1014,0.609,"methylprednisolone, dexamethasone.acetate, prednisolone, deflazacort, halcinonide, fludroxycortide, triamcinolone, flumethasone.pivalate, rimexolone, fluticasone.propionate, desonide, flumethasone, prednisolone.acetate, beclomethasone.dipropionate, ciclesonide, halobetasol.propionate, fluocinolone.acetonide",0.872895201635192,0.215382707367125,FALSE +"A549","Pearson.est","glutamate receptor antagonist",0.2729,0.834,0.649,161,0.775,"felbamate, CPP, CGP.37849",0.187755303199631,0.11069829749369,FALSE +"A549","Pearson.est","glycogen synthase kinase inhibitor",-0.3269,-0.809,0.725,1318,0.999,"TWS.119, kenpaullone",0.139661993429006,0.000434511774017692,FALSE +"A549","Pearson.est","growth factor receptor inhibitor",-0.63016,-1.54,0.0481,1371,0.708,"PHA.848125, AZD3463",1.31785492362617,0.149966742310231,FALSE +"A549","Pearson.est","HCV inhibitor",-0.36842,-0.904,0.603,855,1,"narlaprevir, Ro.9187, mericitabine",0.219682687859849,0,FALSE +"A549","Pearson.est","HDAC inhibitor",0.58289,1.79,0.024,248,0.119,"M.344, vorinostat, PCI.24781, tacedinaline, nexturastat.a, R306465, chidamide, NSC.3852, panobinostat, romidepsin, ACY.1215, trichostatin.a, pyroxamide, JNJ.26481585",1.61978875828839,0.924453038607469,TRUE +"A549","Pearson.est","histamine receptor antagonist",-0.252,-0.606,0.93,979,1,"zolantidine, cimetidine, tiotidine, BF2.649, pheniramine, terfenadine, nizatidine",0.0315170514460649,0,FALSE +"A549","Pearson.est","HMGCR inhibitor",0.33495,0.984,0.497,965,0.656,"pitavastatin, simvastatin, atorvastatin, mevastatin, lovastatin, fluvastatin",0.303643611266668,0.18309616062434,FALSE +"A549","Pearson.est","HSP inhibitor",-0.33644,-0.82,0.707,1049,1,"BIIB021, NVP.AUY922, PU.H71, ganetespib, SNX.2112, tanespimycin",0.150580586203101,0,FALSE +"A549","Pearson.est","JAK inhibitor",-0.44934,-1.09,0.35,1102,0.953,"CEP.33779, AT.9283, AZ960, WHI.P154, TG.101209, filgotinib",0.455931955649724,0.0209070993616736,FALSE +"A549","Pearson.est","KIT inhibitor",-0.30175,-0.732,0.823,1420,1,"KI.8751, dasatinib",0.0846001647877302,0,FALSE +"A549","Pearson.est","MDM inhibitor",-0.64964,-1.59,0.0238,1069,1,"serdemetan, nutlin.3, CGM097, idasanutlin, RITA",1.62342304294349,0,FALSE +"A549","Pearson.est","MEK inhibitor",-0.40769,-1,0.461,854,0.939,"U.0126, PD.184352, trametinib, Ro.4987655, PD.198306, selumetinib, TAK.733, PD.0325901, refametinib, AZD8330, PD.318088, arctigenin, nobiletin",0.336299074610352,0.0273344077338891,FALSE +"A549","Pearson.est","MET inhibitor",-0.3784,-0.926,0.574,804,1,"PHA.665752, NVP.BVU972, LY2801653, PF.04217903",0.241088107602027,0,FALSE +"A549","Pearson.est","microtubule inhibitor",-0.41579,-1.01,0.449,810,0.942,"vinblastine, cabazitaxel, secnidazole, D.64131, cytochalasin.b, podophyllotoxin",0.347753658996677,0.0259490972071227,FALSE +"A549","Pearson.est","mTOR inhibitor",-0.60826,-1.51,0.0639,958,0.681,"everolimus, OSI.027, deforolimus, PI.103, LY303511, PKI.179, palomid.529, voxtalisib, temsirolimus, WYE.125132, XL388, PP242, AZD2014, sirolimus, LY3023414, GSK2126458, NVP.BEZ235, GDC.0980, AZD8055, WAY.600, ku.0063794, MLN0128, SB.2343, WYE.354, torin.1",1.1944991418416,0.166852888087215,FALSE +"A549","Pearson.est","NFkB pathway inhibitor",0.25891,0.766,0.781,304,0.749,"parthenolide...., Ro.106.9920, parthenolide, bortezomib, bindarit, curcumin, tyloxapol",0.1073489661227,0.125518182300534,FALSE +"A549","Pearson.est","opioid receptor agonist",-0.49664,-1.2,0.251,830,0.864,"BW.180C, spiradoline, salvinorin.a, cebranopadol, trimebutine",0.600326278518962,0.0634862575211067,FALSE +"A549","Pearson.est","p38 MAPK inhibitor",-0.23173,-0.57,0.953,598,0.978,"CMPD.1, SB.242235, TAK.715, VX.702, skepinone.l",0.0209070993616736,0.00966114521239857,FALSE +"A549","Pearson.est","PARP inhibitor",-0.41165,-1.03,0.443,1437,0.95,"E7449",0.35359627377693,0.0222763947111523,FALSE +"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.37088,-0.91,0.597,1342,1,"CP.673451, KI.8751, crenolanib, dasatinib",0.224025668870631,0,FALSE +"A549","Pearson.est","phosphatase inhibitor",-0.25892,-0.637,0.898,1410,1,"mycophenolic.acid",0.0467236633326956,0,FALSE +"A549","Pearson.est","phosphodiesterase inhibitor",-0.33559,-0.817,0.715,1308,1,"zardaverine, YM.976",0.145693958198919,0,FALSE +"A549","Pearson.est","PI3K inhibitor",-0.46642,-1.14,0.297,993,0.925,"PI.103, LY303511, YM.201636, BGT226, PKI.179, voxtalisib, PI3K.IN.2, TG.100713, LY3023414, GDC.0941, GSK2126458, ZSTK.474, NVP.BEZ235, GDC.0980, SB.2343",0.527243550682788,0.0338582672609674,FALSE +"A549","Pearson.est","PLK inhibitor",-0.46077,-1.14,0.309,763,0.925,"HMN.214, BI.2536, GSK461364, volasertib, rigosertib, GW.843682X",0.510041520575165,0.0338582672609674,FALSE +"A549","Pearson.est","potassium channel blocker",-0.51452,-1.25,0.186,1203,0.795,"ibutilide, ML133",0.730487055782084,0.0996328713435297,FALSE +"A549","Pearson.est","PPAR receptor agonist",0.5059,1.57,0.0432,719,0.187,"pterostilbene, clofibrate, GW.501516, ciprofibrate, fenofibrate, S26948, oleoylethanolamide",1.36451625318509,0.728158393463501,TRUE +"A549","Pearson.est","progesterone receptor agonist",-0.41685,-1.02,0.445,1051,0.946,"dienogest, tanaproget, melengestrol.acetate",0.351639989019068,0.0241088635982073,FALSE +"A549","Pearson.est","proteasome inhibitor",0.51258,1.55,0.0783,231,0.152,"ONX.0914, carfilzomib, delanzomib, oprozomib, bortezomib",1.10623823794206,0.818156412055227,FALSE +"A549","Pearson.est","protein synthesis inhibitor",-0.49133,-1.2,0.219,1210,0.864,"emetine, brefeldin.a, methacycline, cycloheximide, mercaptopurine, florfenicol",0.659555885159882,0.0634862575211067,FALSE +"A549","Pearson.est","protein tyrosine kinase inhibitor",-0.3291,-0.813,0.708,1083,1,"NVP.TAE226, mubritinib, BMS.599626",0.149966742310231,0,FALSE +"A549","Pearson.est","RAF inhibitor",0.39358,1.15,0.268,154,0.468,"vemurafenib, TAK.632, regorafenib, AZ.628",0.571865205971211,0.329754146925876,FALSE +"A549","Pearson.est","RET tyrosine kinase inhibitor",0.35506,1.05,0.376,936,0.584,"regorafenib, sorafenib, sunitinib, cabozantinib, apatinib, vandetanib",0.424812155072339,0.233587152887601,FALSE +"A549","Pearson.est","retinoid receptor agonist",0.65541,1.94,0.024,318,0.0828,"fenretinide, adapalene, adarotene, tamibarotene, AM.580, CD.437",1.61978875828839,1.08196966321512,TRUE +"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.26455,-0.646,0.899,894,1,"cladribine, clofarabine, triapine, gemcitabine",0.0462403082667712,0,FALSE +"A549","Pearson.est","serotonin receptor agonist",-0.5982,-1.48,0.0652,1362,0.682,"aripiprazole, ipsapirone",1.18575240426808,0.166215625343521,FALSE +"A549","Pearson.est","serotonin receptor antagonist",-0.23574,-0.578,0.932,1296,0.989,"RS.16566, aripiprazole",0.0305840876460186,0.0048037084028206,FALSE +"A549","Pearson.est","sodium channel blocker",-0.36995,-0.905,0.586,1323,1,"A.803467, ajmaline, butamben",0.232102383981909,0,FALSE +"A549","Pearson.est","src inhibitor",-0.43544,-1.08,0.359,1397,0.945,"bosutinib, dasatinib",0.444905551421681,0.0245681914907371,FALSE +"A549","Pearson.est","sterol demethylase inhibitor",-0.36538,-0.892,0.601,670,0.977,"terconazole, sulconazole, lanoconazole, ketoconazole",0.22112552799726,0.0101054362812269,FALSE +"A549","Pearson.est","TGF beta receptor inhibitor",0.29126,0.868,0.58,1028,0.824,"LY2109761, D.4476, SB.525334, SB.431542, repsox, adaprev",0.236572006437063,0.0840727883028842,FALSE +"A549","Pearson.est","thymidylate synthase inhibitor",-0.5782,-1.41,0.0883,1253,0.548,"ftorafur, raltitrexed, carmofur",1.05403929642243,0.261219441515631,FALSE +"A549","Pearson.est","topoisomerase inhibitor",-0.44189,-1.11,0.347,1319,0.975,"exatecan.mesylate, teniposide, voreloxin, amsacrine, fleroxacin, idarubicin, TAS.103",0.459670525209126,0.0109953843014632,FALSE +"A549","Pearson.est","tubulin polymerization inhibitor",-0.42805,-1.05,0.396,810,0.961,"vinblastine, fenbendazole, dolastatin.10, plinabulin, albendazole, taltobulin, docetaxel, ABT.751, CYT.997, BNC105, parbendazole, epothilone.d, combretastatin.A.4, KX2.391, podophyllotoxin, verubulin, epothilone.b",0.402304814074488,0.0172766123314547,FALSE +"A549","Pearson.est","tyrosine kinase inhibitor",-0.26078,-0.626,0.902,833,1,"cabozantinib, hypericin, apatinib, vandetanib, UNC2250, NVP.TAE226, GTP.14564, aminopurvalanol.a, mubritinib, BMS.599626, dasatinib",0.0447934624580583,0,FALSE +"A549","Pearson.est","VEGFR inhibitor",-0.24381,-0.595,0.933,603,1,"tivozanib, sunitinib, SAR131675, semaxanib, SU014813, AEE788, motesanib, foretinib, PD.173074, TG.100572, ENMD.2076, RAF265, cabozantinib, nintedanib, BMS.690514, cediranib, vandetanib, ZM.306416, vatalanib, XL.647, telatinib, lucitanib, MGCD.265, KI.8751",0.0301183562535,0,FALSE +"A549","Pearson.est","vitamin D receptor agonist",-0.32022,-0.782,0.742,840,1,"alfacalcidol, ercalcitriol, tacalcitol",0.129596094720973,0,FALSE +"H1703","Pearson.est","EGFR inhibitor",0.82362,2.03,0,57,0.0668,"poziotinib, AZD8931, gefitinib, dacomitinib, XL.647, neratinib, afatinib, canertinib, lapatinib, erlotinib, osimertinib, BIBU.1361, AST.1306, pelitinib, BMS.690514, PD.153035, vandetanib, CUDC.101, tucatinib, icotinib, BMS.599626, ARRY.334543, PD.168393, WZ8040",Inf,1.17522353752445,TRUE +"H1703","Pearson.est","Abl kinase inhibitor",0.46962,1.2,0.265,104,0.877,"dasatinib, ZM.306416, bosutinib",0.576754126063192,0.0570004066339595,FALSE +"H1703","Pearson.est","acetylcholine receptor agonist",-0.28411,-0.709,0.807,1007,0.904,"nefiracetam, xanomeline, oxiracetam",0.0931264652779296,0.0438315695246367,FALSE +"H1703","Pearson.est","acetylcholine receptor antagonist",-0.56334,-1.38,0.126,1032,0.534,"diphemanil, darifenacin, iododexetimide, methscopolamine",0.899629454882437,0.272458742971444,FALSE +"H1703","Pearson.est","adenosine receptor antagonist",0.68445,1.73,0.0294,170,0.216,"CGS.15943, MRS.1220, SCH.58261, PSB.1115",1.53165266958784,0.665546248849069,TRUE +"H1703","Pearson.est","adrenergic receptor agonist",0.26044,0.654,0.893,150,0.977,"ritodrine, oxymetazoline, isoxsuprine",0.0491485411114536,0.0101054362812269,FALSE +"H1703","Pearson.est","adrenergic receptor antagonist",-0.30126,-0.735,0.782,1286,0.912,"metoprolol, carvedilol, pindolol",0.106793246940152,0.0400051616715838,FALSE +"H1703","Pearson.est","AKT inhibitor",0.4272,1.06,0.381,414,0.769,"uprosertib, triciribine, AZD5363, GDC.0068, CCT128930, MK.2206, GSK2110183, palomid.529",0.419075024324381,0.114073660198569,FALSE +"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.20058,0.526,0.968,523,1,"GW.788388, SB.505124, brigatinib, alectinib, AZD3463, CEP.37440, AP26113, NVP.TAE684",0.0141246426916063,0,FALSE +"H1703","Pearson.est","androgen receptor antagonist",-0.47712,-1.16,0.296,688,0.661,"cyproterone.acetate, bicalutamide, enzalutamide, RU.58841, nilutamide, flutamide",0.528708288941061,0.17979854051436,FALSE +"H1703","Pearson.est","antioxidant",0.4485,1.12,0.306,44,0.921,"mesna",0.51427857351842,0.0357403698031511,FALSE +"H1703","Pearson.est","AP inhibitor",-0.40077,-0.989,0.48,1417,0.77,"idronoxil",0.318758762624413,0.113509274827518,FALSE +"H1703","Pearson.est","ATPase inhibitor",-0.61923,-1.51,0.0802,984,0.498,"evodiamine, blebbistatin...., ouabain, omeprazole, k.strophanthidin, thonzonium, digitoxin, digitoxigenin, digoxin, oligomycin.a",1.09582563171584,0.302770657240282,FALSE +"H1703","Pearson.est","Aurora kinase inhibitor",-0.63111,-1.57,0.0538,988,0.41,"hesperadin, TAK.901, alisertib, KW.2449, MK.5108, CCT137690, MK.8745, tozasertib, danusertib, barasertib.HQPA, AT.9283, aurora.a.inhibitor.i, ZM.447439, SNS.314, PF.03814735, AMG900, barasertib",1.26921772433361,0.387216143280265,FALSE +"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.21224,0.54,0.954,432,1,"tedizolid, azithromycin, azalomycin.b, tilmicosin",0.0204516252959049,0,FALSE +"H1703","Pearson.est","bacterial DNA gyrase inhibitor",0.31223,0.796,0.693,46,0.932,"finafloxacin",0.159266765388193,0.0305840876460186,FALSE +"H1703","Pearson.est","BCL inhibitor",-0.32548,-0.794,0.711,776,0.916,"venetoclax, navitoclax, ABT.737, HA14.1, TW.37, oridonin",0.148130399270234,0.0381045263321496,FALSE +"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.40935,1.03,0.421,104,0.744,"dasatinib, bosutinib",0.375717904164332,0.128427064454121,FALSE +"H1703","Pearson.est","benzodiazepine receptor agonist",0.17979,0.456,0.991,1190,0.99,"piperazine, CL.218872, lorazepam, zaleplon, ivermectin, eprinomectin, gamma.aminobutyric.acid, ZK.93423, CGS.20625, temazepam, bentazepam, nefiracetam, indiplon",0.00392634551472468,0.00436480540245009,FALSE +"H1703","Pearson.est","bromodomain inhibitor",0.39459,0.993,0.423,879,0.705,"JQ1...., OTX015, I.BET.762, I.BET151, bromosporine, PFI.1",0.373659632624958,0.151810883008601,FALSE +"H1703","Pearson.est","calcium channel blocker",-0.32585,-0.795,0.738,1060,0.939,"penfluridol, pranidipine, SR.33805, carboxyamidotriazole",0.131943638176958,0.0273344077338891,FALSE +"H1703","Pearson.est","CC chemokine receptor antagonist",-0.3392,-0.827,0.648,1261,0.911,"MK.0812, UNBS.5162",0.188424994129407,0.0404816230270017,FALSE +"H1703","Pearson.est","CDK inhibitor",0.19668,0.494,0.975,237,1,"indirubin, alvocidib, P276.00, TG.02, AZD5438",0.0109953843014632,0,FALSE +"H1703","Pearson.est","CHK inhibitor",-0.34312,-0.832,0.652,1110,0.929,"SB.218078, PF.477736",0.18575240426808,0.0319842860063582,FALSE +"H1703","Pearson.est","cyclooxygenase inhibitor",-0.39138,-0.977,0.459,1370,0.765,"tepoxalin, suxibuzone, AM.404, naproxen",0.338187314462739,0.116338564846382,FALSE +"H1703","Pearson.est","cytochrome P450 inhibitor",-0.35725,-0.876,0.594,1104,0.9,"clotrimazole, metyrapone, cobicistat",0.226213555018806,0.0457574905606751,FALSE +"H1703","Pearson.est","DNA alkylating agent",-0.49277,-1.19,0.25,1080,0.666,"TH.302, mitomycin.c, carboplatin, satraplatin, cisplatin, dianhydrogalactitol, melphalan",0.602059991327962,0.176525770829699,FALSE +"H1703","Pearson.est","DNA inhibitor",-0.4796,-1.14,0.32,1122,0.671,"tirapazamine, pibenzimol, carboplatin, valrubicin, melphalan, chlorambucil",0.494850021680094,0.173277479831008,FALSE +"H1703","Pearson.est","DNA methyltransferase inhibitor",0.46029,1.17,0.309,210,0.872,"azacitidine, decitabine, fdcyd",0.510041520575165,0.0594835150674328,FALSE +"H1703","Pearson.est","DNA polymerase inhibitor",-0.28929,-0.712,0.794,1123,0.921,"menadione, cephalomannine",0.100179497572904,0.0357403698031511,FALSE +"H1703","Pearson.est","DNA synthesis inhibitor",-0.53567,-1.33,0.158,1157,0.518,"enocitabine, mitomycin.c, estramustine.phosphate, azodicarbonamide, cisplatin, artemisinin",0.801342913045577,0.285670240254767,FALSE +"H1703","Pearson.est","dopamine receptor antagonist",0.42894,1.08,0.385,221,0.822,"domperidone, clebopride, lurasidone, acetophenazine, mesoridazine, oxiperomide",0.414539270491499,0.0851281824599496,FALSE +"H1703","Pearson.est","estrogen receptor agonist",0.35167,0.923,0.518,198,0.768,"erteberel, levonorgestrel, ethinyl.estradiol",0.285670240254767,0.114638779968488,FALSE +"H1703","Pearson.est","estrogen receptor antagonist",0.43335,1.1,0.331,111,0.833,"clomifene, raloxifene",0.480172006224281,0.0793549985932124,FALSE +"H1703","Pearson.est","FGFR inhibitor",-0.58078,-1.4,0.121,1216,0.536,"regorafenib, lenvatinib, dovitinib, nintedanib, erdafitinib",0.91721462968355,0.27083521030723,FALSE +"H1703","Pearson.est","FLT3 inhibitor",-0.41291,-0.997,0.472,1036,0.812,"KW.2449, tyrphostin.AG.1296, tozasertib, quizartinib, sorafenib, TG.101348, midostaurin, dovitinib",0.326058001365912,0.0904439707588247,FALSE +"H1703","Pearson.est","glucocorticoid receptor agonist",0.55382,1.41,0.0874,295,0.618,"hydrocortisone, triamcinolone.acetonide, ciclesonide, fluocinolone.acetonide, flumethasone.pivalate, desonide, difluprednate, methylprednisolone, dexamethasone.acetate, fludroxycortide, prednisolone, flumethasone, halobetasol.propionate",1.0584885673656,0.209011524911184,FALSE +"H1703","Pearson.est","glutamate receptor antagonist",0.39271,1.01,0.427,340,0.708,"diazooxonorleucine, SIB.1757, CGP.37849, IEM1754, kynurenic.acid, latrepirdine, CPP",0.369572124974976,0.149966742310231,FALSE +"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.33722,0.85,0.618,152,0.869,"indirubin, LY2090314",0.209011524911184,0.0609802235513335,FALSE +"H1703","Pearson.est","growth factor receptor inhibitor",0.30297,0.771,0.676,71,0.942,"GSK1904529A",0.170053304058364,0.0259490972071227,FALSE +"H1703","Pearson.est","HCV inhibitor",-0.35152,-0.864,0.612,1038,0.896,"Ro.9187, mericitabine, narlaprevir",0.213248577854439,0.0476919903378748,FALSE +"H1703","Pearson.est","HDAC inhibitor",-0.19195,-0.471,0.99,677,0.986,"trichostatin.a, AR.42, vorinostat, M.344, R306465, nexturastat.a, RGFP966, mocetinostat, dacinostat, NSC.3852, ACY.1215, SB.939, belinostat, pyroxamide, RG2833, entinostat, resminostat, scriptaid, chidamide",0.00436480540245009,0.0061230850587888,FALSE +"H1703","Pearson.est","histamine receptor antagonist",0.29217,0.733,0.753,181,0.936,"ranitidine, terfenadine, levocetirizine, astemizole",0.123205023799299,0.0287241512618947,FALSE +"H1703","Pearson.est","HMGCR inhibitor",-0.94383,-2.26,0,1408,0,"fluvastatin, mevastatin, atorvastatin, pitavastatin",Inf,Inf,TRUE +"H1703","Pearson.est","HSP inhibitor",-0.52095,-1.28,0.211,1069,0.584,"PU.H71, SNX.2112, NVP.AUY922, ganetespib, NMS.E973",0.675717544702307,0.233587152887601,FALSE +"H1703","Pearson.est","JAK inhibitor",-0.27921,-0.678,0.842,1154,0.921,"tozasertib, ruxolitinib, AT.9283, TG.101348, PRT062070",0.0746879085003505,0.0357403698031511,FALSE +"H1703","Pearson.est","KIT inhibitor",-0.50547,-1.24,0.232,1180,0.598,"telatinib, cediranib, regorafenib, sorafenib, midostaurin, motesanib, lenvatinib, pazopanib",0.6345120151091,0.223298816011589,FALSE +"H1703","Pearson.est","MDM inhibitor",-0.37108,-0.901,0.586,1121,0.882,"AMG.232, serdemetan",0.232102383981909,0.0545314148681803,FALSE +"H1703","Pearson.est","MEK inhibitor",0.84685,2.18,0,107,0.0169,"trametinib, AS.703026, cobimetinib, AZD8330, TAK.733, PD.0325901, selumetinib, Ro.4987655, MEK162, PD.318088, refametinib, PD.198306, PD.184352",Inf,1.77211329538633,TRUE +"H1703","Pearson.est","MET inhibitor",-0.40727,-1,0.442,1126,0.836,"LY2801653, AMG458",0.354577730650908,0.0777937225609836,FALSE +"H1703","Pearson.est","microtubule inhibitor",-0.61266,-1.49,0.0643,881,0.429,"triclabendazole, colchicine, D.64131, cytochalasin.b, podophyllotoxin, estramustine.phosphate, cabazitaxel, secnidazole, vinflunine, vinblastine",1.19178902707578,0.367542707815276,FALSE +"H1703","Pearson.est","mTOR inhibitor",0.26649,0.663,0.832,378,0.999,"GSK2126458, LY303511, PP242, WAY.600, XL388, WYE.354, OSI.027, PF.04691502, GDC.0980, voxtalisib, WYE.125132",0.0798766737092761,0.000434511774017692,FALSE +"H1703","Pearson.est","NFkB pathway inhibitor",-0.19837,-0.48,0.981,1325,1,"BAY.11.7082",0.0083309926200515,0,FALSE +"H1703","Pearson.est","opioid receptor agonist",-0.22538,-0.54,0.957,325,1,"ADL5859, trimebutine, BW.180C, cebranopadol, salvinorin.a, spiradoline",0.0190880622231565,0,FALSE +"H1703","Pearson.est","p38 MAPK inhibitor",0.54823,1.39,0.135,658,0.584,"SB.239063, TAK.715, talmapimod, SB.242235, skepinone.l, CMPD.1, VX.702",0.869666231504994,0.233587152887601,FALSE +"H1703","Pearson.est","PARP inhibitor",-0.59277,-1.45,0.0952,1307,0.471,"olaparib, AZD2461, talazoparib",1.02136305161553,0.326979092871104,FALSE +"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.55008,-1.35,0.161,1171,0.515,"crenolanib, telatinib, trapidil, regorafenib, CP.673451, linifanib, sorafenib, motesanib, lenvatinib, dovitinib, axitinib, nintedanib, pazopanib",0.79317412396815,0.288192770958809,FALSE +"H1703","Pearson.est","phosphatase inhibitor",-0.42808,-1.05,0.407,1062,0.765,"AS.1949490, menadione, BVT.948, GSK2830371, bis.maltolato.oxovanadium.IV.",0.39040559077478,0.116338564846382,FALSE +"H1703","Pearson.est","phosphodiesterase inhibitor",-0.40968,-0.996,0.476,1176,0.785,"zardaverine, YM.976, enoximone, GSK256066",0.322393047279507,0.105130343254747,FALSE +"H1703","Pearson.est","PI3K inhibitor",0.4203,1.05,0.398,351,0.746,"alpelisib, taselisib, GSK2126458, TG.100713, CH5132799, LY303511, GDC.0941, PIK.75, PF.04691502, PI.828, GDC.0980, AZD6482, voxtalisib",0.400116927926312,0.127261172527331,FALSE +"H1703","Pearson.est","PLK inhibitor",-0.64391,-1.59,0.0495,1127,0.726,"GSK461364, HMN.214, BI.2536, rigosertib, volasertib",1.30539480106643,0.139063379299906,FALSE +"H1703","Pearson.est","potassium channel blocker",-0.5592,-1.36,0.151,1416,0.534,"dofetilide",0.821023052706831,0.272458742971444,FALSE +"H1703","Pearson.est","PPAR receptor agonist",-0.44832,-1.12,0.342,1054,0.655,"pterostilbene, clofibrate, GW.501516",0.465973893943865,0.183758700008217,FALSE +"H1703","Pearson.est","progesterone receptor agonist",-0.31414,-0.767,0.75,982,0.911,"danazol, dienogest, tanaproget, norgestrel, norethindrone",0.1249387366083,0.0404816230270017,FALSE +"H1703","Pearson.est","proteasome inhibitor",-0.45691,-1.12,0.324,926,0.655,"ixazomib, oprozomib, delanzomib, ONX.0914, MG.132",0.489454989793388,0.183758700008217,FALSE +"H1703","Pearson.est","protein synthesis inhibitor",-0.51746,-1.27,0.21,1161,0.569,"thiostrepton, clofoctol, puromycin, bruceantin, mercaptopurine, homoharringtonine, harringtonine, anguidine",0.677780705266081,0.244887733604929,FALSE +"H1703","Pearson.est","protein tyrosine kinase inhibitor",0.54835,1.43,0.105,200,0.664,"BMS.599626, AV.412, NVP.TAE226, CP.724714",0.978810700930062,0.177831920631982,FALSE +"H1703","Pearson.est","RAF inhibitor",0.30081,0.767,0.733,156,0.914,"AZ.628, CEP.32496, SB.590885",0.134896025358872,0.0390538042661686,FALSE +"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.44018,1.11,0.323,29,0.873,"vandetanib",0.490797477668897,0.0589857562944303,FALSE +"H1703","Pearson.est","retinoid receptor agonist",0.40017,1.01,0.441,48,0.708,"CD.437, tamibarotene",0.355561410532161,0.149966742310231,FALSE +"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.63686,-1.57,0.0595,963,0.41,"hydroxyurea, fludarabine.phosphate, triapine, gemcitabine, fludarabine, cladribine, clofarabine, pentostatin",1.22548303427145,0.387216143280265,FALSE +"H1703","Pearson.est","serotonin receptor agonist",-0.62589,-1.57,0.0587,1151,0.41,"SR.57227A, pardoprunox, aripiprazole",1.23136189875239,0.387216143280265,FALSE +"H1703","Pearson.est","serotonin receptor antagonist",-0.47896,-1.17,0.268,1262,0.674,"paliperidone, lerisetron, aripiprazole",0.571865205971211,0.17134010346468,FALSE +"H1703","Pearson.est","sodium channel blocker",-0.25562,-0.619,0.909,1021,0.963,"brivaracetam, triamterene, oxcarbazepine, butamben, cibenzoline",0.0414361167780325,0.0163737128754655,FALSE +"H1703","Pearson.est","src inhibitor",0.66148,1.76,0.0208,104,0.224,"saracatinib, dasatinib, ZM.306416, bosutinib",1.68193666503724,0.649751981665837,TRUE +"H1703","Pearson.est","sterol demethylase inhibitor",-0.31245,-0.772,0.73,1392,0.927,"chlormidazole",0.136677139879544,0.0329202658555029,FALSE +"H1703","Pearson.est","TGF beta receptor inhibitor",0.38532,0.99,0.458,480,0.679,"repsox, D.4476, SB.431542, LY2109761",0.339134521996131,0.168130225719498,FALSE +"H1703","Pearson.est","thymidylate synthase inhibitor",0.46965,1.2,0.249,364,0.877,"carmofur, capecitabine, raltitrexed",0.603800652904264,0.0570004066339595,FALSE +"H1703","Pearson.est","topoisomerase inhibitor",-0.73872,-1.81,0.0152,1243,0.23,"irinotecan, dexrazoxane, rubitecan, voreloxin, doxorubicin, valrubicin, mitoxantrone, TAS.103, amonafide, nemorubicin, daunorubicin, teniposide, etoposide, topotecan, etoposide.phosphate, epirubicin",1.81815641205523,0.638272163982407,TRUE +"H1703","Pearson.est","tubulin polymerization inhibitor",-0.60989,-1.5,0.0875,973,0.458,"fosbretabulin, epothilone.b, podophyllotoxin, mebendazole, fenbendazole, flubendazole, plinabulin, vinorelbine, docetaxel, epothilone.d, ABT.751, dolastatin.10, paclitaxel, CYT.997, vincristine, combretastatin.A.4, vindesine, KX2.391, vinblastine, verubulin, taltobulin, BNC105",1.05799194697769,0.339134521996131,FALSE +"H1703","Pearson.est","tyrosine kinase inhibitor",0.41593,1.06,0.374,200,0.769,"vandetanib, dasatinib, BMS.599626, AV.412, NVP.TAE226, hypericin, GTP.14564, CP.724714",0.42712839779952,0.114073660198569,FALSE +"H1703","Pearson.est","VEGFR inhibitor",-0.30703,-0.751,0.753,1180,0.912,"telatinib, cediranib, regorafenib, SAR131675, RAF265, linifanib, sorafenib, motesanib, lenvatinib, dovitinib, axitinib, tivozanib, nintedanib, pazopanib",0.123205023799299,0.0400051616715838,FALSE +"H1703","Pearson.est","vitamin D receptor agonist",0.70695,1.79,0.0187,321,0.254,"tacalcitol, paricalcitol, calcitriol, maxacalcitol, ercalcitriol, alfacalcidol",1.7281583934635,0.595166283380062,FALSE +"HCC15","Pearson.est","EGFR inhibitor",0.7297,1.75,0.00865,80,0.649,"gefitinib, poziotinib, afatinib, pelitinib, XL.647, CUDC.101, AZD8931, erlotinib, dacomitinib, BIBU.1361, AST.1306, osimertinib, lapatinib, neratinib, vandetanib, canertinib, icotinib, PD.153035, WZ.4002, tucatinib",2.06298389253519,0.187755303199631,FALSE +"HCC15","Pearson.est","Abl kinase inhibitor",0.56625,1.35,0.148,484,0.67,"dasatinib, ZM.306416, tozasertib, GZD824, nilotinib, ponatinib, imatinib, bosutinib",0.829738284605043,0.173925197299174,FALSE +"HCC15","Pearson.est","acetylcholine receptor agonist",-0.3505,-0.923,0.483,1398,0.728,"nefiracetam",0.316052869248488,0.137868620686963,FALSE +"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.27741,-0.739,0.748,1143,0.878,"darifenacin, diphemanil, methscopolamine",0.126098402135539,0.0565054840938974,FALSE +"HCC15","Pearson.est","adenosine receptor antagonist",0.48282,1.19,0.243,301,0.717,"istradefylline, sulmazole, CGS.15943, PSB.1115",0.614393726401688,0.1444808443322,FALSE +"HCC15","Pearson.est","adrenergic receptor agonist",0.30493,0.732,0.778,334,0.955,"ritodrine, terbutaline, oxymetazoline, methyldopa, isoxsuprine",0.109020403010311,0.0199966284162537,FALSE +"HCC15","Pearson.est","adrenergic receptor antagonist",-0.3474,-0.935,0.538,1306,0.74,"levobunolol, metoprolol, propranolol, pindolol",0.269217724333611,0.130768280269024,FALSE +"HCC15","Pearson.est","AKT inhibitor",0.38654,0.927,0.548,384,0.793,"uprosertib, MK.2206, GSK2110183, triciribine, AT7867",0.261219441515631,0.100726812682396,FALSE +"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.49057,1.17,0.273,400,0.697,"lorlatinib, SB.505124, CEP.37440, alectinib, AZD3463",0.563837352959244,0.156767221901991,FALSE +"HCC15","Pearson.est","androgen receptor antagonist",-0.82341,-2.22,0.00342,1256,0.0411,"flutamide, RU.58841, enzalutamide, cyproterone.acetate",2.46597389394387,1.38615817812393,TRUE +"HCC15","Pearson.est","antioxidant",-0.45702,-1.2,0.266,1426,0.628,"taurine, rutin",0.575118363368933,0.202040356262804,FALSE +"HCC15","Pearson.est","AP inhibitor",-0.43189,-1.16,0.257,1212,0.653,"birinapant, LCL.161, GDC.0152",0.590066876668705,0.185086818724926,FALSE +"HCC15","Pearson.est","ATPase inhibitor",-0.48383,-1.3,0.193,1266,0.707,"omeprazole, digitoxin, rabeprazole, digitoxigenin, oligomycin.a",0.714442690992226,0.150580586203101,FALSE +"HCC15","Pearson.est","Aurora kinase inhibitor",0.12973,0.308,0.999,320,1,"GSK1070916, tozasertib, ENMD.2076",0.000434511774017692,0,FALSE +"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.26389,-0.709,0.792,380,0.858,"tedizolid, valnemulin, azithromycin, tilmicosin, azalomycin.b, dirithromycin, radezolid, josamycin",0.101274818410506,0.0665127121512946,FALSE +"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.21394,0.514,0.978,380,0.989,"finafloxacin, novobiocin, sarafloxacin",0.00966114521239857,0.0048037084028206,FALSE +"HCC15","Pearson.est","BCL inhibitor",0.34132,0.809,0.67,346,0.886,"obatoclax, gossypol, venetoclax",0.173925197299174,0.0525662781129492,FALSE +"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",0.57356,1.38,0.122,484,0.921,"dasatinib, tozasertib, GZD824, nilotinib, ponatinib, imatinib, bosutinib",0.913640169325252,0.0357403698031511,FALSE +"HCC15","Pearson.est","benzodiazepine receptor agonist",0.26517,0.64,0.891,543,0.961,"ZK.93423, piperazine, bentazepam, zaleplon, CL.218872, eprinomectin",0.0501222959631252,0.0172766123314547,FALSE +"HCC15","Pearson.est","bromodomain inhibitor",0.46165,1.14,0.31,491,0.701,"JQ1...., I.BET.762, OTX015, I.BET151",0.508638306165727,0.154281982033341,FALSE +"HCC15","Pearson.est","calcium channel blocker",0.41373,0.993,0.461,560,0.737,"tetrandrine, SKF.96365, efonidipine.monoethanolate, penfluridol, mibefradil, fendiline",0.336299074610352,0.132532512140949,FALSE +"HCC15","Pearson.est","CC chemokine receptor antagonist",0.55356,1.35,0.155,173,0.67,"ZK811752, PF.04136309",0.809668301829709,0.173925197299174,FALSE +"HCC15","Pearson.est","CDK inhibitor",0.49761,1.18,0.295,385,0.706,"indisulam, P276.00, alvocidib, AT.7519, TG.02, dinaciclib, AZD5438, ribociclib, PHA.848125, palbociclib, JNJ.7706621",0.530177984021837,0.151195298948196,FALSE +"HCC15","Pearson.est","CHK inhibitor",-0.32408,-0.875,0.615,467,0.747,"LY2603618, AZD7762, LY2606368, PF.477736, SCH.900776, CHIR.124, SB.218078",0.211124884224583,0.126679398184601,FALSE +"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.4483,-1.24,0.2,1347,0.611,"AM.404, sulfasalazine, metoxibutropate, suxibuzone, naproxen",0.698970004336019,0.213958789757446,FALSE +"HCC15","Pearson.est","cytochrome P450 inhibitor",0.49946,1.2,0.252,165,0.731,"morin, metyrapone",0.598599459218456,0.13608262304214,FALSE +"HCC15","Pearson.est","DNA alkylating agent",-0.38211,-1.04,0.329,1151,0.623,"streptozotocin, ifosfamide, melphalan, satraplatin, cisplatin, dianhydrogalactitol, mitomycin.c",0.482804102050026,0.20551195334083,FALSE +"HCC15","Pearson.est","DNA inhibitor",0.22993,0.549,0.945,229,0.992,"sangivamycin, carmustine, bendamustine",0.0245681914907371,0.00348832784582135,FALSE +"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.39417,0.945,0.502,225,0.782,"decitabine, azacitidine",0.299296282854981,0.106793246940152,FALSE +"HCC15","Pearson.est","DNA polymerase inhibitor",0.40542,0.994,0.467,193,0.758,"cidofovir, idoxuridine",0.330683119433888,0.120330794367946,FALSE +"HCC15","Pearson.est","DNA synthesis inhibitor",-0.60115,-1.68,0.0639,1322,0.286,"floxuridine, cisplatin, artemisinin, estramustine.phosphate, mitomycin.c",1.1944991418416,0.543633966870957,FALSE +"HCC15","Pearson.est","dopamine receptor antagonist",0.45684,1.08,0.391,250,0.687,"clebopride, lurasidone, domperidone, mesoridazine, sertindole, amisulpride, thioproperazine",0.407823242604133,0.16304326294045,FALSE +"HCC15","Pearson.est","estrogen receptor agonist",-0.29437,-0.81,0.645,1442,0.828,"estradiol.cypionate",0.190440285364732,0.0819696632151199,FALSE +"HCC15","Pearson.est","estrogen receptor antagonist",0.63709,1.55,0.0579,134,0.529,"raloxifene, clomifene",1.23732143627256,0.276544327964814,FALSE +"HCC15","Pearson.est","FGFR inhibitor",0.40749,0.998,0.457,318,0.774,"PD.173074, MK.2461, lucitanib, regorafenib",0.34008379993015,0.111259039317107,FALSE +"HCC15","Pearson.est","FLT3 inhibitor",0.4217,1.03,0.417,430,0.736,"gilteritinib, pacritinib, tozasertib, TG.02, sunitinib, ENMD.2076, sorafenib, ponatinib, tyrphostin.AG.1296",0.379863945026242,0.133122185662501,FALSE +"HCC15","Pearson.est","glucocorticoid receptor agonist",0.52471,1.25,0.208,327,0.687,"hydrocortisone, ciclesonide, triamcinolone.acetonide, difluprednate, flumethasone.pivalate, halcinonide, halobetasol.propionate, fluocinolone.acetonide, prednisolone.acetate, desonide, prednisolone",0.681936665037238,0.16304326294045,FALSE +"HCC15","Pearson.est","glutamate receptor antagonist",0.28399,0.693,0.832,354,0.965,"SIB.1757, CPP, diazooxonorleucine, CGP.37849",0.0798766737092761,0.0154726866562074,FALSE +"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.18838,-0.512,0.971,1218,0.978,"indirubin, CHIR.98014",0.0127807700919951,0.00966114521239857,FALSE +"HCC15","Pearson.est","growth factor receptor inhibitor",0.46534,1.13,0.317,501,0.664,"GSK1904529A, GSK1838705A, PHA.848125, AZD3463, lestaurtinib, danusertib",0.498940737782249,0.177831920631982,FALSE +"HCC15","Pearson.est","HCV inhibitor",0.34683,0.83,0.679,47,0.897,"embelin",0.168130225719498,0.0472075569559079,FALSE +"HCC15","Pearson.est","HDAC inhibitor",0.51246,1.26,0.221,360,0.706,"PCI.24781, R306465, M.344, romidepsin, JNJ.26481585, dacinostat, givinostat, belinostat, trichostatin.a, NSC.3852, vorinostat, panobinostat, tacedinaline, entinostat, nexturastat.a",0.655607726314889,0.151195298948196,FALSE +"HCC15","Pearson.est","histamine receptor antagonist",0.34689,0.828,0.671,479,0.877,"ranitidine, astemizole, pheniramine, ebastine, chloropyramine, tecastemizole, lafutidine",0.173277479831008,0.0570004066339595,FALSE +"HCC15","Pearson.est","HMGCR inhibitor",0.48141,1.16,0.295,470,0.688,"lovastatin, pitavastatin, simvastatin",0.530177984021837,0.162411561764489,FALSE +"HCC15","Pearson.est","HSP inhibitor",-0.4397,-1.14,0.286,1253,0.642,"XL888, KW.2478, alvespimycin, VER.49009, tanespimycin",0.543633966870957,0.192464971931147,FALSE +"HCC15","Pearson.est","JAK inhibitor",0.37889,0.91,0.574,389,0.803,"atiprimod, pacritinib, tozasertib, TG.02, filgotinib, AZD1480",0.241088107602027,0.095284454721319,FALSE +"HCC15","Pearson.est","KIT inhibitor",0.27329,0.658,0.885,483,0.962,"dasatinib, sunitinib, regorafenib, sorafenib, imatinib, vatalanib",0.0530567293021746,0.0168249279621871,FALSE +"HCC15","Pearson.est","MDM inhibitor",0.43923,1.09,0.364,154,0.692,"nutlin.3, idasanutlin",0.438898616350944,0.159893905543242,FALSE +"HCC15","Pearson.est","MEK inhibitor",0.69964,1.72,0.0189,156,0.421,"cobimetinib, AZD8330, MEK162, TAK.733, AS.703026, trametinib, PD.0325901, Ro.4987655, selumetinib, MEK1.2.inhibitor",1.72353819582676,0.375717904164332,FALSE +"HCC15","Pearson.est","MET inhibitor",-0.62128,-1.69,0.0635,1099,0.34,"INC.280, AMG458, NVP.BVU972",1.19722627470802,0.468521082957745,FALSE +"HCC15","Pearson.est","microtubule inhibitor",-0.35202,-0.961,0.494,1358,0.729,"cytochalasin.b, estramustine.phosphate",0.306273051076353,0.137272471682025,FALSE +"HCC15","Pearson.est","mTOR inhibitor",0.2973,0.715,0.79,145,0.957,"GSK2126458, WAY.600, LY303511, XL388, OSI.027",0.102372908709559,0.0190880622231565,FALSE +"HCC15","Pearson.est","NFkB pathway inhibitor",0.52477,1.26,0.209,266,0.706,"curcumin, parthenolide...., bortezomib, Ro.106.9920, parthenolide",0.679853713888946,0.151195298948196,FALSE +"HCC15","Pearson.est","opioid receptor agonist",-0.40083,-1.06,0.395,578,0.626,"trimebutine, salvinorin.a, cebranopadol, ADL5859, BW.180C, spiradoline",0.40340290437354,0.20342566678957,FALSE +"HCC15","Pearson.est","p38 MAPK inhibitor",0.56299,1.34,0.153,583,0.642,"SB.242235, SB.239063, TAK.715, CMPD.1, talmapimod, VX.702",0.815308569182401,0.192464971931147,FALSE +"HCC15","Pearson.est","PARP inhibitor",-0.41383,-1.11,0.295,1235,0.612,"olaparib, AZD2461, E7449",0.530177984021837,0.213248577854439,FALSE +"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.19253,-0.522,0.959,1173,1,"crenolanib, lenvatinib, motesanib, tandutinib, trapidil, nintedanib, linifanib",0.0181813928293364,0,FALSE +"HCC15","Pearson.est","phosphatase inhibitor",0.50615,1.21,0.232,361,0.749,"GSK2830371, alexidine, CID.5458317, bis.maltolato.oxovanadium.IV., sodium.stibogluconate",0.6345120151091,0.125518182300534,FALSE +"HCC15","Pearson.est","phosphodiesterase inhibitor",-0.39081,-1.07,0.361,1157,0.644,"zardaverine, papaverine, GSK256066, YM.976, enoximone",0.442492798094342,0.191114132640188,FALSE +"HCC15","Pearson.est","PI3K inhibitor",0.35581,0.853,0.657,503,0.879,"buparlisib, YM.201636, GSK2126458, LY303511, TG.100713, taselisib, GDC.0941, PIK.75, AZD6482, CUDC.907, PF.04691502, pilaralisib, PF.05212384",0.182434630440219,0.0560111249262281,FALSE +"HCC15","Pearson.est","PLK inhibitor",-0.48448,-1.32,0.185,1111,0.757,"GSK461364, HMN.214, GW.843682X, BI.2536, volasertib",0.732828271596986,0.120904120499927,FALSE +"HCC15","Pearson.est","potassium channel blocker",-0.47471,-1.27,0.184,1267,0.616,"dofetilide, ML133",0.735182176990464,0.210419287835575,FALSE +"HCC15","Pearson.est","PPAR receptor agonist",-0.47031,-1.28,0.186,1108,0.662,"clofibrate, pterostilbene, ciprofibrate, GW.501516",0.730487055782084,0.1791420105603,FALSE +"HCC15","Pearson.est","progesterone receptor agonist",-0.50578,-1.35,0.136,1402,0.804,"dienogest, norgestrel",0.866461091629782,0.0947439512515487,FALSE +"HCC15","Pearson.est","proteasome inhibitor",0.4017,0.992,0.462,195,0.717,"carfilzomib, bortezomib",0.335358024443874,0.1444808443322,FALSE +"HCC15","Pearson.est","protein synthesis inhibitor",0.46752,1.11,0.346,417,0.679,"brefeldin.a, clindamycin.phosphate, chloramphenicol.palmitate, homoharringtonine, azomycin..2.nitroimidazole., cycloheximide, bruceantin, tedizolid.phosphate",0.460923901207223,0.168130225719498,FALSE +"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.46669,1.13,0.294,377,0.664,"AV.412, NVP.TAE226, PP.121",0.531652669587843,0.177831920631982,FALSE +"HCC15","Pearson.est","RAF inhibitor",0.63823,1.51,0.0622,200,0.557,"AZ.628, dabrafenib, vemurafenib, CEP.32496, LGX818, SB.590885",1.20620961530918,0.254144804826271,FALSE +"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.57362,1.37,0.125,406,0.751,"vandetanib, sunitinib, regorafenib, sorafenib",0.903089986991944,0.124360062995832,FALSE +"HCC15","Pearson.est","retinoid receptor agonist",0.71117,1.7,0.0219,194,0.322,"tamibarotene, CD.437, adarotene, AM.580",1.65955588515988,0.492144128304169,FALSE +"HCC15","Pearson.est","ribonucleotide reductase inhibitor",-0.40211,-1.11,0.309,1086,0.612,"pentostatin, fludarabine, cytarabine, hydroxyurea, clofarabine, gemcitabine",0.510041520575165,0.213248577854439,FALSE +"HCC15","Pearson.est","serotonin receptor agonist",-0.66371,-1.84,0.0226,1447,0.323,"aripiprazole",1.6458915608526,0.490797477668897,FALSE +"HCC15","Pearson.est","serotonin receptor antagonist",-0.31928,-0.892,0.58,1447,0.748,"aripiprazole",0.236572006437063,0.126098402135539,FALSE +"HCC15","Pearson.est","sodium channel blocker",-0.26782,-0.709,0.771,1276,0.858,"cibenzoline, lappaconite, oxcarbazepine",0.112945621949043,0.0665127121512946,FALSE +"HCC15","Pearson.est","src inhibitor",0.64064,1.56,0.0495,105,0.627,"saracatinib, dasatinib, ZM.306416, PP.2",1.30539480106643,0.202732459169284,FALSE +"HCC15","Pearson.est","sterol demethylase inhibitor",0.27717,0.669,0.855,465,0.972,"terconazole, sulconazole, lanoconazole",0.0680338852718274,0.0123337350737254,FALSE +"HCC15","Pearson.est","TGF beta receptor inhibitor",0.57039,1.37,0.15,66,0.751,"repsox, D.4476",0.823908740944319,0.124360062995832,FALSE +"HCC15","Pearson.est","thymidylate synthase inhibitor",0.53782,1.3,0.177,44,0.697,"carmofur",0.752026733638193,0.156767221901991,FALSE +"HCC15","Pearson.est","topoisomerase inhibitor",-0.63409,-1.75,0.0422,1117,0.341,"daunorubicin, epirubicin, camptothecin, rubitecan, valrubicin, amsacrine, teniposide, exatecan.mesylate, etoposide, idarubicin, nemorubicin, genz.644282, voreloxin, TAS.103, amonafide, mitoxantrone",1.37468754903833,0.467245621007502,FALSE +"HCC15","Pearson.est","tubulin polymerization inhibitor",0.23288,0.556,0.952,541,1,"nocodazole, indibulin, vindesine, vinorelbine, oxibendazole, podophyllotoxin, plinabulin, albendazole, mebendazole, vincristine, verubulin, parbendazole",0.0213630516155257,0,FALSE +"HCC15","Pearson.est","tyrosine kinase inhibitor",0.42549,1.03,0.423,406,0.736,"vandetanib, dasatinib, tivantinib, AV.412, NVP.TAE226, sunitinib, regorafenib, PP.121, sorafenib",0.373659632624958,0.133122185662501,FALSE +"HCC15","Pearson.est","VEGFR inhibitor",0.33429,0.801,0.715,320,0.877,"XL.647, vandetanib, ZM.306416, PD.173074, BMS.690514, MK.2461, lucitanib, sunitinib, regorafenib, ENMD.2076",0.145693958198919,0.0570004066339595,FALSE +"HCC15","Pearson.est","vitamin D receptor agonist",-0.27967,-0.753,0.734,403,0.89,"alfacalcidol, calcitriol, tacalcitol, ercalcitriol, paricalcitol, maxacalcitol, doxercalciferol",0.134303940083929,0.0506099933550872,FALSE diff --git a/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_venn_diagram.pdf b/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_venn_diagram.pdf new file mode 100644 index 0000000000000000000000000000000000000000..575f51bb80243a73e2e42d828d4654178f459f50 GIT binary patch literal 7608 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+
+
+ + + + diff --git a/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_mean_results.csv b/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..ca89807 --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"mTOR inhibitor",1.749,0.0773168463974192,1.81770657168265e-15,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC827",5.02898818165532e-14 +"AP inhibitor",1.6535,0.0755523520132685,4.54471748498591e-11,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",4.71514439067288e-10 +"DNA methyltransferase inhibitor",1.568,0.164303954528442,4.91911199325153e-09,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",4.53651439377641e-08 +"potassium channel blocker",1.5105,0.0971962204160115,2.77990508975808e-07,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",1.92276768708267e-06 +"cytochrome P450 inhibitor",1.42335,0.138754715424852,1.86814499856125e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.000103370689920389 +"vitamin D receptor agonist",1.356,0.151844796108603,0.000210101338773053,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.00108990069488521 +"HSP inhibitor",1.322,0.149968417727832,0.000926496321902759,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.00452348204223112 +"HDAC inhibitor",1.166,0.0569764494284585,0.0967786388401707,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.401631351186709 +"benzodiazepine receptor agonist",1.1104,0.0654461610791649,0.262209222425643,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.946233280927322 +"ATPase inhibitor",1.10575,0.098505610313108,0.276686861938312,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.956875397536664 +"RAF inhibitor",1.0673,0.19274010316595,0.393170355853769,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"AKT inhibitor",1.06345,0.124425617179608,0.462291062814404,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"EGFR inhibitor",1.0527,0.124433072266517,0.510643799893822,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"tubulin polymerization inhibitor",1.03945,0.127331922238897,0.567924069219369,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"HCV inhibitor",1.0226,0.148299270679968,0.642672692732662,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"DNA polymerase inhibitor",1.01125,0.10167744406494,0.719223078754668,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"microtubule inhibitor",0.99945,0.0843223607729041,0.761881356671272,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"proteasome inhibitor",0.9991,0.124047910947852,0.735345838446027,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"bacterial DNA gyrase inhibitor",0.99845,0.143989208294452,0.730843891500061,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"HMGCR inhibitor",0.9921,0.172175522436599,0.756881291720326,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"glycogen synthase kinase inhibitor",0.95645,0.0786340457937574,0.897785829851299,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"PI3K inhibitor",0.94065,0.0646775605763333,0.943152705883192,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"adrenergic receptor antagonist",0.8513,0.0724780184462485,0.997692020232059,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"glutamate receptor antagonist",0.83055,0.0690975473705947,0.999126970013929,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"sodium channel blocker",0.82145,0.13733304696785,0.998915844082484,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"Aurora kinase inhibitor",0.8076,0.157815148362353,0.99929419741276,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"Bcr.Abl kinase inhibitor",0.77715,0.525378387450417,0.94424779269903,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"retinoid receptor agonist",0.75985,0.387731631958308,0.998284025469237,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"PLK inhibitor",0.7465,0.540690932243667,0.975484102506319,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"protein synthesis inhibitor",0.7229,0.079108120549297,0.999999557876575,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"topoisomerase inhibitor",0.6587,0.300590489046582,0.999999881659007,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"sterol demethylase inhibitor",0.6391,0.672213773954935,0.977773940363725,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"phosphodiesterase inhibitor",0.49995,0.480694943750575,0.999999995001786,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"tyrosine kinase inhibitor",0.4205,0.552137616331672,0.999999996706063,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"acetylcholine receptor agonist",0.40895,0.518550964353147,0.999999999849094,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"Abl kinase inhibitor",0.37755,0.738387679873841,0.99961702078595,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"VEGFR inhibitor",0.1306,0.582349180836594,0.999999999999998,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"adenosine receptor antagonist",-0.18175,0.95280096087936,0.917186682244559,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"MDM inhibitor",-0.2309,0.807614740096448,0.999364086978706,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"KIT inhibitor",-0.2856,0.775155970722905,0.999845525377226,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"protein tyrosine kinase inhibitor",-0.3517,0.788012964093198,0.998627128197425,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"thymidylate synthase inhibitor",-0.38475,0.729261694058486,0.999704979167057,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"CC chemokine receptor antagonist",-0.5173,0.450509080462256,0.999999997141223,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"CDK inhibitor",-0.56825,0.397803558371002,0.999999943267046,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"BCL inhibitor",-0.5941,0.788819097398797,0.856055565248078,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"p38 MAPK inhibitor",-0.59935,0.281905783999959,0.999999999540895,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"DNA inhibitor",-0.6392,0.0693348852727793,0.999999999971843,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"histamine receptor antagonist",-0.6692,0.0774124972910841,0.999999998631121,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"DNA synthesis inhibitor",-0.69915,0.31092955286062,0.999980156599818,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"bacterial 50S ribosomal subunit inhibitor",-0.7296,0.64428143572592,0.88420601736604,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"MEK inhibitor",-0.7445,0.11614306060336,0.999992140327109,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"PPAR receptor agonist",-0.7485,0.383463646805082,0.998646186855031,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"phosphatase inhibitor",-0.75555,0.353245922239659,0.998967731258152,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"FGFR inhibitor",-0.7957,0.169341790782025,0.999560383339883,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"estrogen receptor agonist",-0.8011,0.336723672436239,0.995423765507422,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"DNA alkylating agent",-0.85255,0.126899659905811,0.995109343422822,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"ALK tyrosine kinase receptor inhibitor",-0.89135,0.160093812957804,0.975707463200835,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"RET tyrosine kinase inhibitor",-0.90055,0.436464199412072,0.788218544040761,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"calcium channel blocker",-0.9185,0.0999376121177081,0.952838069351939,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"PDGFR tyrosine kinase receptor inhibitor",-0.9307,0.160510403007669,0.923144648720296,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"src inhibitor",-0.93535,0.18186758485517,0.914419006996309,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"FLT3 inhibitor",-0.945,0.0965810267953396,0.916365472930537,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"JAK inhibitor",-0.9644,0.112318813159122,0.853814317801295,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"glucocorticoid receptor agonist",-0.96475,0.14640170943782,0.853809512985718,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"dopamine receptor antagonist",-0.97,0.0769059576092092,0.855963497237929,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"ribonucleotide reductase inhibitor",-0.9703,0.0602469479462828,0.847431868676047,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"cyclooxygenase inhibitor",-1.01165,0.0935016324090542,0.682258748045896,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"adrenergic receptor agonist",-1.04165,0.0581715023375753,0.563684692077703,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"serotonin receptor antagonist",-1.043,0.453502161545362,0.179402530951814,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.709067146142885 +"NFkB pathway inhibitor",-1.0561,0.0797086140758622,0.486194204375438,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998 +"opioid receptor agonist",-1.1162,0.0597922719878889,0.245329067947084,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.925559665436727 +"bromodomain inhibitor",-1.1776,0.228974694074074,0.0539383000035225,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.235625205278546 +"CHK inhibitor",-1.1927,0.212135036437196,0.0356117705564163,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.164209830899031 +"TGF beta receptor inhibitor",-1.465,0.155817031701997,6.26067247011913e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",3.7116843929992e-05 +"PARP inhibitor",-1.472,0.0869119336485291,3.82990686108232e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",2.44524822669102e-05 +"growth factor receptor inhibitor",-1.5185,0.135734842131345,1.66808731112601e-07,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"HCC4006, H460",1.25864769839508e-06 +"antioxidant",-1.59,0.14682606967716,7.00979812697237e-09,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"HCC4006, HCC2279, HCC44",5.81813244538707e-08 +"progesterone receptor agonist",-1.6565,0.210694965343391,4.48035671584148e-12,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,8,"H358, H3255, H1648, H2126, HCC2279, H520, HCC15, HCC44",6.19782679024738e-11 +"MET inhibitor",-1.7265,0.218180876194139,1.33276086328534e-11,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,10,"H358, HCC95, HCC78, CALU3, H2009, HCC2279, H460, A549, H1703, H1299",1.58027359503833e-10 +"serotonin receptor agonist",-1.7526,0.22556231488158,3.81555527937888e-15,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,14,"H358, H1650, H1648, HCC78, H2126, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44",7.91727720471117e-14 +"androgen receptor antagonist",-1.9005,0.0845716762341425,2.06191825891495e-19,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,18,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, CALU3, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",8.55696077449703e-18 +"acetylcholine receptor antagonist",-1.936,0.0916170519637382,1.00447673629914e-20,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,19,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",8.33715691128287e-19 +"estrogen receptor antagonist",-2.1135,0.0883935577552549,9.28727143852532e-15,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,20,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",1.5416870587952e-13 diff --git a/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_results.csv b/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_results.csv new file mode 100644 index 0000000..6cee985 --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_results.csv @@ -0,0 +1,1661 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"H358","Pearson.est","EGFR inhibitor",0.40339,1.02,0.442,307,0.857,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, erlotinib, BMS.690514, WZ.3146, brigatinib, XL.647, canertinib, PD.168393, gefitinib, BIBU.1361, BIBX.1382, AST.1306, icotinib, AZD8931, pelitinib",0.354577730650908,0.0670191780768018,FALSE +"H358","Pearson.est","Abl kinase inhibitor",-0.21057,-0.566,0.956,1181,0.985,"imatinib, KW.2449, flumatinib",0.0195421077238999,0.00656376950238827,FALSE +"H358","Pearson.est","acetylcholine receptor agonist",0.18207,0.473,0.996,165,0.986,"xanomeline",0.00174066157630127,0.0061230850587888,FALSE +"H358","Pearson.est","acetylcholine receptor antagonist",-0.76326,-1.95,0.00607,1322,0.152,"iododexetimide, dicycloverine, methscopolamine",2.21681130892474,0.818156412055227,TRUE +"H358","Pearson.est","adenosine receptor antagonist",-0.38629,-0.986,0.437,1428,1,"istradefylline",0.359518563029578,0,FALSE +"H358","Pearson.est","adrenergic receptor agonist",-0.41,-1.07,0.367,1052,1,"clenbuterol, xylazine, ritodrine, midodrine, methyldopa, oxymetazoline, norepinephrine, isoetharine",0.435333935747911,0,FALSE +"H358","Pearson.est","adrenergic receptor antagonist",0.33404,0.858,0.633,188,0.858,"practolol, propranolol, idazoxan, vincamine",0.198596289982645,0.0665127121512946,FALSE +"H358","Pearson.est","AKT inhibitor",0.38861,1.01,0.427,366,0.833,"MK.2206, triciribine, ONC201, AT7867, palomid.529",0.369572124974976,0.0793549985932124,FALSE +"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.33107,-0.908,0.533,1231,0.899,"alectinib, CEP.37440, DMH1",0.273272790973428,0.0462403082667712,FALSE +"H358","Pearson.est","androgen receptor antagonist",-0.71669,-1.85,0.00828,1055,0.218,"bicalutamide, nilutamide, flutamide, enzalutamide, cyproterone.acetate",2.08196966321512,0.661543506395395,TRUE +"H358","Pearson.est","antioxidant",-0.64627,-1.66,0.0363,1200,0.301,"benfotiamine, trolox",1.44009337496389,0.521433504406157,FALSE +"H358","Pearson.est","AP inhibitor",0.68798,1.77,0.0252,59,0.732,"birinapant, GDC.0152",1.59859945921846,0.135488918941608,FALSE +"H358","Pearson.est","ATPase inhibitor",0.41834,1.07,0.383,289,0.983,"k.strophanthidin, oligomycin.a, evodiamine, blebbistatin...., ouabain",0.416801226031377,0.00744648216786438,FALSE +"H358","Pearson.est","Aurora kinase inhibitor",0.31149,0.801,0.693,564,0.89,"MK.5108, barasertib.HQPA, MK.8745, ENMD.2076, barasertib, alisertib, PF.03814735, ZM.447439, MLN.8054, CCT137690, SNS.314, AMG900, danusertib",0.159266765388193,0.0506099933550872,FALSE +"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.39566,-1.03,0.386,1359,1,"azalomycin.b, dirithromycin",0.413412695328245,0,FALSE +"H358","Pearson.est","bacterial DNA gyrase inhibitor",0.48743,1.27,0.211,144,1,"lomefloxacin, novobiocin, finafloxacin",0.675717544702307,0,FALSE +"H358","Pearson.est","BCL inhibitor",-0.34022,-0.88,0.556,1385,0.841,"gossypol, ABT.737",0.254925208417942,0.0752040042020878,FALSE +"H358","Pearson.est","Bcr.Abl kinase inhibitor",0.26067,0.679,0.824,304,0.948,"dasatinib, metatinib, bafetinib",0.0840727883028842,0.0231916626619338,FALSE +"H358","Pearson.est","benzodiazepine receptor agonist",0.41764,1.07,0.379,141,0.983,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.421360790031928,0.00744648216786438,FALSE +"H358","Pearson.est","bromodomain inhibitor",-0.62006,-1.56,0.0789,982,0.379,"bromosporine, JQ1...., I.BET151, PFI.1",1.10292299679058,0.421360790031928,FALSE +"H358","Pearson.est","calcium channel blocker",-0.38051,-1.02,0.407,1224,1,"efonidipine.monoethanolate, SR.33805, mibefradil",0.39040559077478,0,FALSE +"H358","Pearson.est","CC chemokine receptor antagonist",-0.20402,-0.544,0.972,294,0.958,"ZK811752, UNBS.5162, MK.0812, RS.504393, SB.225002, navarixin, PF.04136309",0.0123337350737254,0.0186344909214556,FALSE +"H358","Pearson.est","CDK inhibitor",-0.32523,-0.867,0.597,941,0.841,"BMS.387032, palbociclib, PHA.848125, arcyriaflavin.a, R547, indirubin, AZD5438, abemaciclib, ribociclib, BMS.265246, JNJ.7706621, TG.02",0.224025668870631,0.0752040042020878,FALSE +"H358","Pearson.est","CHK inhibitor",-0.37743,-0.983,0.435,1083,1,"SCH.900776, AZD7762, SB.218078",0.361510743045363,0,FALSE +"H358","Pearson.est","cyclooxygenase inhibitor",-0.342,-0.891,0.58,1247,0.875,"acetylsalicylsalicylic.acid, FR.122047, piroxicam, tryptanthrin, naproxen",0.236572006437063,0.0579919469776868,FALSE +"H358","Pearson.est","cytochrome P450 inhibitor",0.6093,1.55,0.069,254,0.816,"PF.4981517, eplerenone, morin",1.16115090926274,0.0883098412461389,FALSE +"H358","Pearson.est","DNA alkylating agent",-0.28961,-0.753,0.739,1027,0.92,"TH.302, streptozotocin, carmustine, cyclophosphamide, melphalan, satraplatin, temozolomide",0.131355561605174,0.0362121726544447,FALSE +"H358","Pearson.est","DNA inhibitor",-0.21882,-0.582,0.942,1062,1,"primaquine, carmustine, melphalan, busulfan, nithiamide, pibenzimol",0.0259490972071227,0,FALSE +"H358","Pearson.est","DNA methyltransferase inhibitor",0.54864,1.42,0.125,485,0.832,"decitabine, azacitidine, SGI.1027, fdcyd",0.903089986991944,0.0798766737092761,FALSE +"H358","Pearson.est","DNA polymerase inhibitor",0.37945,0.982,0.469,138,0.848,"cephalomannine, foscarnet, cidofovir",0.328827157284917,0.0716041477432862,FALSE +"H358","Pearson.est","DNA synthesis inhibitor",-0.22121,-0.578,0.94,1245,0.998,"altretamine, enocitabine",0.0268721464003014,0.000869458712628891,FALSE +"H358","Pearson.est","dopamine receptor antagonist",-0.36009,-0.944,0.489,1101,0.958,"mesoridazine, nemonapride, remoxipride, ziprasidone, paliperidone, amisulpride, lurasidone",0.31069114087638,0.0186344909214556,FALSE +"H358","Pearson.est","estrogen receptor agonist",-0.33575,-0.846,0.609,1195,0.856,"estrone, erteberel",0.215382707367125,0.0675262353228468,FALSE +"H358","Pearson.est","estrogen receptor antagonist",-0.80158,-2.07,0.00211,1257,0.0962,"danazol, raloxifene, fulvestrant, tamoxifen",2.67571754470231,1.01682492796219,TRUE +"H358","Pearson.est","FGFR inhibitor",-0.29795,-0.771,0.761,1010,0.915,"nintedanib, MK.2461, lenvatinib, lucitanib",0.118615343229427,0.0385789059335517,FALSE +"H358","Pearson.est","FLT3 inhibitor",-0.35743,-0.929,0.521,1128,0.921,"TG.101348, quizartinib, KW.2449, pacritinib, TG.02, sunitinib, lestaurtinib",0.283162276700476,0.0357403698031511,FALSE +"H358","Pearson.est","glucocorticoid receptor agonist",-0.37382,-0.972,0.488,906,0.972,"fludroxycortide, triamcinolone, desonide, clobetasol.propionate, triamcinolone.acetonide, halcinonide, prednisolone, halobetasol.propionate, prednisolone.acetate, flumethasone, rimexolone, beclomethasone.dipropionate, fluticasone.propionate, fluocinolone.acetonide, piretanide, flumethasone.pivalate, dexamethasone.acetate, hydrocortisone",0.311580177997289,0.0123337350737254,FALSE +"H358","Pearson.est","glutamate receptor antagonist",0.32873,0.828,0.645,195,0.878,"ACDPP, tiletamine, kynurenic.acid",0.190440285364732,0.0565054840938974,FALSE +"H358","Pearson.est","glycogen synthase kinase inhibitor",0.35703,0.958,0.479,53,0.854,"CHIR.99021",0.319664486585437,0.068542129310995,FALSE +"H358","Pearson.est","growth factor receptor inhibitor",-0.60071,-1.54,0.085,1216,0.371,"GSK1838705A, GW.441756, lestaurtinib",1.07058107428571,0.430626090384954,FALSE +"H358","Pearson.est","HCV inhibitor",0.35051,0.891,0.568,100,0.868,"daclatasvir",0.245651664288981,0.0614802748235081,FALSE +"H358","Pearson.est","HDAC inhibitor",0.45829,1.18,0.278,401,1,"chidamide, nexturastat.a, panobinostat, NSC.3852, belinostat, SB.939, scriptaid, entinostat, ACY.1215, M.344, mocetinostat, romidepsin, resminostat, givinostat",0.555955204081924,0,FALSE +"H358","Pearson.est","histamine receptor antagonist",-0.27476,-0.72,0.799,1137,0.947,"terfenadine, tiotidine, ranitidine, BF2.649, ebastine, epinastine",0.0974532206860086,0.0236500209967266,FALSE +"H358","Pearson.est","HMGCR inhibitor",0.39822,1.02,0.42,202,0.857,"atorvastatin, simvastatin",0.3767507096021,0.0670191780768018,FALSE +"H358","Pearson.est","HSP inhibitor",0.47046,1.22,0.226,283,1,"BIIB021, NMS.E973, PU.H71, SNX.2112, NVP.AUY922, ganetespib, SNX.5422",0.645891560852599,0,FALSE +"H358","Pearson.est","JAK inhibitor",-0.38869,-1,0.438,1128,1,"TG.101348, CEP.33779, AZD1480, pacritinib, filgotinib, TG.02, lestaurtinib",0.3585258894959,0,FALSE +"H358","Pearson.est","KIT inhibitor",-0.33479,-0.885,0.552,1181,0.858,"imatinib, lenvatinib, vatalanib, telatinib, sunitinib, masitinib",0.258060922270801,0.0665127121512946,FALSE +"H358","Pearson.est","MDM inhibitor",0.22816,0.59,0.915,1119,0.983,"serdemetan, idasanutlin, AMG.232, CGM097, nutlin.3, RITA",0.0385789059335517,0.00744648216786438,FALSE +"H358","Pearson.est","MEK inhibitor",-0.2082,-0.544,0.947,1199,0.958,"MEK162, BIX.02188, nobiletin, arctigenin",0.0236500209967266,0.0186344909214556,FALSE +"H358","Pearson.est","MET inhibitor",-0.67837,-1.79,0.0185,1172,0.242,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.73282827159699,0.616184634019569,TRUE +"H358","Pearson.est","microtubule inhibitor",0.42673,1.1,0.345,389,1,"estramustine.phosphate, triclabendazole, podophyllotoxin, cabazitaxel",0.462180904926726,0,FALSE +"H358","Pearson.est","mTOR inhibitor",0.66482,1.72,0.0214,332,0.5,"deforolimus, PI.103, PKI.179, AZD8055, torin.1, everolimus, temsirolimus, NVP.BEZ235, LY3023414, PP242, MLN0128, sirolimus, SB.2343, AZD2014, GDC.0980, torin.2, WYE.125132, PF.04691502, voxtalisib",1.66958622665081,0.301029995663981,FALSE +"H358","Pearson.est","NFkB pathway inhibitor",-0.40209,-1.05,0.392,1206,1,"bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.406713932979543,0,FALSE +"H358","Pearson.est","opioid receptor agonist",-0.41881,-1.1,0.337,1241,1,"ADL5859, salvinorin.a",0.472370099128661,0,FALSE +"H358","Pearson.est","p38 MAPK inhibitor",-0.3008,-0.789,0.73,1326,0.91,"skepinone.l",0.136677139879544,0.0409586076789064,FALSE +"H358","Pearson.est","PARP inhibitor",-0.60063,-1.59,0.0618,1024,0.375,"olaparib, niraparib, AZD2461, AG.14361, talazoparib",1.20901152491118,0.425968732272281,FALSE +"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.37863,-0.98,0.454,1008,0.996,"motesanib, nintedanib, crenolanib, KI.8751, axitinib, imatinib, lenvatinib, vatalanib, telatinib, sunitinib, CP.673451, masitinib",0.342944147142896,0.00174066157630127,FALSE +"H358","Pearson.est","phosphatase inhibitor",-0.34704,-0.907,0.547,1222,0.871,"CID.5458317, menadione, alexidine",0.262012673666569,0.0599818449923368,FALSE +"H358","Pearson.est","phosphodiesterase inhibitor",-0.22847,-0.6,0.926,1198,1,"trequinsin, GSK256066, avanafil",0.0333890133180656,0,FALSE +"H358","Pearson.est","PI3K inhibitor",0.35841,0.948,0.487,332,0.833,"PI.103, PKI.179, NVP.BEZ235, BGT226, LY3023414, SB.2343, GDC.0980, ZSTK.474, PF.04691502, voxtalisib",0.312471038785366,0.0793549985932124,FALSE +"H358","Pearson.est","PLK inhibitor",0.34282,0.91,0.572,954,0.869,"HMN.214, BI.2536, volasertib, GSK461364, rigosertib, NMS.1286937, GW.843682X",0.242603971206976,0.0609802235513335,FALSE +"H358","Pearson.est","potassium channel blocker",0.59895,1.53,0.0732,458,0.667,"ibutilide, ML133, mepivacaine, dofetilide, oleoylethanolamide",1.13548891894161,0.175874166083451,FALSE +"H358","Pearson.est","PPAR receptor agonist",-0.30572,-0.804,0.658,1071,0.908,"clofibrate, S26948, fenofibrate",0.181774106386044,0.0419141514789149,FALSE +"H358","Pearson.est","progesterone receptor agonist",-0.65161,-1.72,0.0246,1130,0.247,"norgestrel, dienogest, melengestrol.acetate, danazol, nomegestrol.acetate, norethindrone.acetate",1.60906489289662,0.607303046740334,TRUE +"H358","Pearson.est","proteasome inhibitor",0.33719,0.876,0.597,193,0.859,"ONX.0914, MG.132",0.224025668870631,0.0660068361687577,FALSE +"H358","Pearson.est","protein synthesis inhibitor",0.27276,0.709,0.804,502,0.939,"clofoctol, cycloheximide, brefeldin.a, thiostrepton, puromycin, methacycline, chloramphenicol.palmitate, azomycin..2.nitroimidazole.",0.0947439512515487,0.0273344077338891,FALSE +"H358","Pearson.est","protein tyrosine kinase inhibitor",-0.25486,-0.65,0.889,1313,0.993,"CP.724714, rheochrysidin",0.0510982390297863,0.00305075150461883,FALSE +"H358","Pearson.est","RAF inhibitor",0.40646,1.05,0.39,427,0.964,"SB.590885, vemurafenib, LGX818, dabrafenib, AZ.628, sorafenib",0.408935392973501,0.0159229660971692,FALSE +"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.3524,-0.933,0.537,1374,0.946,"sunitinib",0.270025714300444,0.0241088635982073,FALSE +"H358","Pearson.est","retinoid receptor agonist",0.40115,1.03,0.429,42,0.947,"LE.135",0.367542707815276,0.0236500209967266,FALSE +"H358","Pearson.est","ribonucleotide reductase inhibitor",-0.3761,-0.967,0.459,1440,0.943,"pentostatin",0.338187314462739,0.0254883072626717,FALSE +"H358","Pearson.est","serotonin receptor agonist",-0.68992,-1.76,0.0292,1335,0.239,"zolmitriptan, ipsapirone, aripiprazole",1.53461714855158,0.621602099051862,TRUE +"H358","Pearson.est","serotonin receptor antagonist",-0.48188,-1.29,0.176,1177,0.754,"RS.16566, ziprasidone, paliperidone, lurasidone, aripiprazole",0.75448733218585,0.122628654130226,FALSE +"H358","Pearson.est","sodium channel blocker",0.29636,0.785,0.71,450,0.853,"brivaracetam, ajmaline, cibenzoline, mexiletine, mepivacaine, butamben",0.148741651280925,0.069050968832477,FALSE +"H358","Pearson.est","src inhibitor",-0.39258,-1.02,0.406,999,1,"TG.100572, bosutinib, PP.1, PP.2, masitinib",0.391473966422806,0,FALSE +"H358","Pearson.est","sterol demethylase inhibitor",-0.35247,-0.909,0.55,1184,0.929,"sulconazole, posaconazole, ketoconazole",0.259637310505756,0.0319842860063582,FALSE +"H358","Pearson.est","TGF beta receptor inhibitor",-0.57122,-1.49,0.092,964,0.412,"repsox, adaprev, SB.525334, SB.431542, D.4476",1.03621217265444,0.385102783966865,FALSE +"H358","Pearson.est","thymidylate synthase inhibitor",-0.24896,-0.657,0.86,359,1,"ftorafur, raltitrexed, doxifluridine, carmofur, capecitabine, trifluridine",0.0655015487564323,0,FALSE +"H358","Pearson.est","topoisomerase inhibitor",0.30593,0.798,0.669,517,0.864,"mitoxantrone, idarubicin, exatecan.mesylate, doxorubicin, amsacrine, epirubicin, voreloxin, rubitecan, camptothecin, etoposide, teniposide, daunorubicin, valrubicin",0.174573882232177,0.0634862575211067,FALSE +"H358","Pearson.est","tubulin polymerization inhibitor",0.40809,1.09,0.352,400,1,"mebendazole, epothilone.b, BNC105, oxibendazole, CYT.997, vinorelbine, fenbendazole, indibulin, taltobulin, verubulin, podophyllotoxin, dolastatin.10",0.453457336521869,0,FALSE +"H358","Pearson.est","tyrosine kinase inhibitor",0.23553,0.626,0.895,427,0.98,"dasatinib, AV.412, NVP.TAE226, bafetinib, vandetanib, mubritinib, tyrphostin.A9, GTP.14564, apatinib, sorafenib",0.048176964684088,0.00877392430750515,FALSE +"H358","Pearson.est","VEGFR inhibitor",0.19918,0.508,0.963,111,1,"BMS.690514, SAR131675, OSI.930, XL.647",0.0163737128754655,0,FALSE +"H358","Pearson.est","vitamin D receptor agonist",0.5404,1.38,0.116,333,0.808,"ercalcitriol, calcitriol, maxacalcitol",0.935542010773082,0.0925886392254138,FALSE +"H1650","Pearson.est","EGFR inhibitor",0.43737,1.13,0.312,335,0.784,"CUDC.101, ARRY.334543, BMS.690514, erlotinib, tyrphostin.AG.1478, XL.647, canertinib, WZ.3146, gefitinib, AST.1306, brigatinib, PD.168393, icotinib, BIBU.1361, BIBX.1382, afatinib, pelitinib, osimertinib, AZD8931, lapatinib",0.505845405981557,0.105683937315562,FALSE +"H1650","Pearson.est","Abl kinase inhibitor",0.40855,1.04,0.386,148,0.888,"dasatinib, metatinib, bafetinib",0.413412695328245,0.051587034221399,FALSE +"H1650","Pearson.est","acetylcholine receptor agonist",0.29338,0.765,0.743,83,0.876,"xanomeline",0.129011186239425,0.0574958938319193,FALSE +"H1650","Pearson.est","acetylcholine receptor antagonist",-0.72074,-1.84,0.0103,1171,0.236,"hyoscyamine, dicycloverine, iododexetimide, methscopolamine",1.98716277529483,0.627087997029893,TRUE +"H1650","Pearson.est","adenosine receptor antagonist",0.34334,0.907,0.556,165,0.905,"theophylline, PSB.1115",0.254925208417942,0.0433514207947967,FALSE +"H1650","Pearson.est","adrenergic receptor agonist",-0.45937,-1.21,0.246,1117,0.908,"lidamidine, xylazine, oxymetazoline, ritodrine, methyldopa, norepinephrine, isoetharine",0.609064892896621,0.0419141514789149,FALSE +"H1650","Pearson.est","adrenergic receptor antagonist",0.29626,0.76,0.737,198,0.858,"practolol, vincamine, idazoxan, propranolol",0.132532512140949,0.0665127121512946,FALSE +"H1650","Pearson.est","AKT inhibitor",0.49716,1.28,0.188,409,0.919,"MK.2206, triciribine, palomid.529, AT7867, ONC201, GSK2110183",0.72584215073632,0.0366844886138887,FALSE +"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.32233,-0.846,0.633,1213,0.905,"alectinib, CEP.37440, DMH1",0.198596289982645,0.0433514207947967,FALSE +"H1650","Pearson.est","androgen receptor antagonist",-0.70446,-1.82,0.0257,1184,0.203,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",1.59006687666871,0.692503962086787,TRUE +"H1650","Pearson.est","antioxidant",-0.5841,-1.5,0.0803,1035,0.571,"benfotiamine, trolox",1.09528445472132,0.243363891754152,FALSE +"H1650","Pearson.est","AP inhibitor",0.63194,1.64,0.0552,111,0.561,"birinapant, GDC.0152",1.2580609222708,0.251037138743839,FALSE +"H1650","Pearson.est","ATPase inhibitor",0.39742,1.03,0.425,383,0.861,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873",0.371611069949688,0.0649968485463452,FALSE +"H1650","Pearson.est","Aurora kinase inhibitor",0.40718,1.04,0.402,548,0.888,"barasertib.HQPA, MK.8745, alisertib, barasertib, MK.5108, ZM.447439, PF.03814735, CCT137690, SNS.314, danusertib, hesperadin, ENMD.2076, AMG900, MLN.8054",0.39577394691553,0.051587034221399,FALSE +"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.38269,-0.997,0.408,1333,0.893,"azalomycin.b, dirithromycin",0.38933983691012,0.0491485411114536,FALSE +"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.31532,0.796,0.694,370,0.881,"lomefloxacin, novobiocin, trovafloxacin, finafloxacin",0.158640529545145,0.0550240915879521,FALSE +"H1650","Pearson.est","BCL inhibitor",-0.36829,-0.966,0.463,1386,0.885,"gossypol, ABT.737",0.334419008982047,0.0530567293021746,FALSE +"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.4627,1.2,0.244,148,0.864,"dasatinib, metatinib, bafetinib",0.612610173661271,0.0634862575211067,FALSE +"H1650","Pearson.est","benzodiazepine receptor agonist",0.46156,1.19,0.265,100,0.815,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.576754126063192,0.0888423912600234,FALSE +"H1650","Pearson.est","bromodomain inhibitor",-0.32216,-0.825,0.646,1096,0.889,"I.BET151, PFI.1",0.189767482004916,0.0510982390297863,FALSE +"H1650","Pearson.est","calcium channel blocker",-0.39734,-1.03,0.376,1295,0.899,"SR.33805, efonidipine.monoethanolate, mibefradil",0.424812155072339,0.0462403082667712,FALSE +"H1650","Pearson.est","CC chemokine receptor antagonist",-0.29493,-0.761,0.74,425,0.897,"MK.0812, UNBS.5162, ZK811752, RS.504393, SB.225002, navarixin, PF.04136309",0.130768280269024,0.0472075569559079,FALSE +"H1650","Pearson.est","CDK inhibitor",-0.23834,-0.622,0.886,1044,0.943,"abemaciclib, R547, indirubin, AZD5438, JNJ.7706621, ribociclib, BMS.265246, TG.02",0.0525662781129492,0.0254883072626717,FALSE +"H1650","Pearson.est","CHK inhibitor",-0.49408,-1.29,0.175,1148,0.77,"AZD7762, SCH.900776, SB.218078",0.756961951313706,0.113509274827518,FALSE +"H1650","Pearson.est","cyclooxygenase inhibitor",-0.42845,-1.1,0.328,1258,0.878,"AM.404, acetylsalicylsalicylic.acid, piroxicam, tryptanthrin, FR.122047, naproxen",0.484126156288321,0.0565054840938974,FALSE +"H1650","Pearson.est","cytochrome P450 inhibitor",0.61218,1.57,0.0545,196,0.594,"PF.4981517, morin, eplerenone",1.26360349772336,0.226213555018806,FALSE +"H1650","Pearson.est","DNA alkylating agent",-0.2796,-0.739,0.788,984,0.907,"melphalan, carmustine, mitomycin.c, streptozotocin, satraplatin, cyclophosphamide, temozolomide",0.103473782510445,0.0423927129399047,FALSE +"H1650","Pearson.est","DNA inhibitor",-0.32429,-0.847,0.638,1207,0.933,"metronidazole, busulfan, pibenzimol, nithiamide",0.195179321278838,0.0301183562535,FALSE +"H1650","Pearson.est","DNA methyltransferase inhibitor",0.66448,1.75,0.0236,483,0.867,"SGI.1027, azacitidine, decitabine, fdcyd, RG108",1.62708799702989,0.0619809025237897,FALSE +"H1650","Pearson.est","DNA polymerase inhibitor",0.36339,0.92,0.55,294,0.92,"cephalomannine, foscarnet, cidofovir, idoxuridine",0.259637310505756,0.0362121726544447,FALSE +"H1650","Pearson.est","DNA synthesis inhibitor",-0.3417,-0.903,0.569,1194,0.916,"artesunate, CB.10.277, altretamine, enocitabine",0.244887733604929,0.0381045263321496,FALSE +"H1650","Pearson.est","dopamine receptor antagonist",-0.4203,-1.1,0.321,1178,0.878,"paliperidone, mesoridazine, ziprasidone, remoxipride, amisulpride, lurasidone",0.493494967595128,0.0565054840938974,FALSE +"H1650","Pearson.est","estrogen receptor agonist",-0.37134,-0.973,0.483,1301,0.909,"estrone, erteberel",0.316052869248488,0.0414361167780325,FALSE +"H1650","Pearson.est","estrogen receptor antagonist",-0.83737,-2.2,0,1321,0.0169,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.77211329538633,TRUE +"H1650","Pearson.est","FGFR inhibitor",-0.21921,-0.566,0.945,1002,0.946,"nintedanib, lucitanib, MK.2461, lenvatinib",0.0245681914907371,0.0241088635982073,FALSE +"H1650","Pearson.est","FLT3 inhibitor",-0.31526,-0.833,0.628,1132,0.902,"TG.101348, pacritinib, quizartinib, TG.02, sunitinib, lestaurtinib",0.202040356262804,0.0447934624580583,FALSE +"H1650","Pearson.est","glucocorticoid receptor agonist",-0.39485,-1.04,0.393,962,0.92,"flumethasone, ciclesonide, fludroxycortide, halcinonide, desonide, prednisolone, triamcinolone.acetonide, triamcinolone, rimexolone, beclomethasone.dipropionate, prednisolone.acetate, fluticasone.propionate, piretanide, fluocinolone.acetonide, flumethasone.pivalate, dexamethasone.acetate, hydrocortisone",0.405607449624573,0.0362121726544447,FALSE +"H1650","Pearson.est","glutamate receptor antagonist",0.30263,0.756,0.737,257,0.838,"ACDPP, tiletamine, kynurenic.acid",0.132532512140949,0.0767559813697235,FALSE +"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.39659,1.02,0.42,39,0.837,"CHIR.99021",0.3767507096021,0.07727454200674,FALSE +"H1650","Pearson.est","growth factor receptor inhibitor",-0.58184,-1.49,0.0884,1388,0.521,"GW.441756, lestaurtinib",1.05354773498693,0.283162276700476,FALSE +"H1650","Pearson.est","HCV inhibitor",0.32453,0.831,0.673,90,0.914,"daclatasvir",0.171984935776023,0.0390538042661686,FALSE +"H1650","Pearson.est","HDAC inhibitor",0.4572,1.18,0.248,384,0.777,"nexturastat.a, chidamide, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, ACY.1215, resminostat, M.344, entinostat, givinostat, mocetinostat",0.605548319173784,0.109578981199086,FALSE +"H1650","Pearson.est","histamine receptor antagonist",-0.23456,-0.609,0.93,1015,0.934,"cyproheptadine, terfenadine, lafutidine, tiotidine, ICI.162846, ranitidine, ebastine, BF2.649, epinastine",0.0315170514460649,0.0296531237699066,FALSE +"H1650","Pearson.est","HMGCR inhibitor",0.29737,0.752,0.759,270,0.82,"atorvastatin, simvastatin",0.11975822410452,0.0861861476162833,FALSE +"H1650","Pearson.est","HSP inhibitor",0.56969,1.48,0.094,235,0.707,"BIIB021, PU.H71, NMS.E973, SNX.5422, NVP.AUY922, SNX.2112, ganetespib",1.0268721464003,0.150580586203101,FALSE +"H1650","Pearson.est","JAK inhibitor",-0.42393,-1.11,0.3,1132,0.968,"TG.101348, pacritinib, CEP.33779, AZD1480, filgotinib, TG.02, lestaurtinib",0.522878745280338,0.0141246426916063,FALSE +"H1650","Pearson.est","KIT inhibitor",-0.25608,-0.648,0.858,1128,0.937,"imatinib, lenvatinib, vatalanib, telatinib, sunitinib, masitinib",0.0665127121512946,0.0282604091122217,FALSE +"H1650","Pearson.est","MDM inhibitor",-0.30991,-0.813,0.693,1071,0.884,"CGM097, nutlin.3, RITA",0.159266765388193,0.0535477349869269,FALSE +"H1650","Pearson.est","MEK inhibitor",-0.31401,-0.812,0.661,1070,0.861,"PD.0325901, nobiletin, PD.318088, BIX.02188, refametinib, MEK162, arctigenin",0.17979854051436,0.0649968485463452,FALSE +"H1650","Pearson.est","MET inhibitor",-0.61558,-1.6,0.0485,1043,0.443,"PF.04217903, INC.280, PHA.665752, NVP.BVU972, AMG458",1.31425826139774,0.35359627377693,FALSE +"H1650","Pearson.est","microtubule inhibitor",0.39046,1,0.431,488,0.836,"estramustine.phosphate, triclabendazole, cabazitaxel, D.64131, podophyllotoxin",0.365522729839268,0.0777937225609836,FALSE +"H1650","Pearson.est","mTOR inhibitor",0.65427,1.69,0.0245,293,0.637,"deforolimus, PI.103, AZD8055, PKI.179, temsirolimus, everolimus, torin.1, LY3023414, NVP.BEZ235, MLN0128, AZD2014, PP242, GDC.0980, WYE.125132, sirolimus, torin.2, SB.2343, palomid.529",1.61083391563547,0.19586056766465,FALSE +"H1650","Pearson.est","NFkB pathway inhibitor",-0.43556,-1.14,0.289,1229,0.951,"bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.539102157243452,0.0218194830625861,FALSE +"H1650","Pearson.est","opioid receptor agonist",-0.38983,-1.05,0.361,1231,0.946,"ADL5859, salvinorin.a",0.442492798094342,0.0241088635982073,FALSE +"H1650","Pearson.est","p38 MAPK inhibitor",-0.25013,-0.655,0.878,939,0.952,"SB.242235, CMPD.1, TAK.715, skepinone.l",0.0565054840938974,0.0213630516155257,FALSE +"H1650","Pearson.est","PARP inhibitor",-0.53469,-1.4,0.142,937,0.65,"PJ.34, niraparib, AZD2461, olaparib, AG.14361, talazoparib",0.847711655616944,0.187086643357144,FALSE +"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30689,-0.797,0.696,945,0.862,"crenolanib, motesanib, ponatinib, nintedanib, linifanib, KI.8751, imatinib, axitinib, lenvatinib, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.157390760389438,0.0644927341752872,FALSE +"H1650","Pearson.est","phosphatase inhibitor",-0.27988,-0.72,0.779,1118,0.912,"CID.5458317, menadione, alexidine",0.108462542327436,0.0400051616715838,FALSE +"H1650","Pearson.est","phosphodiesterase inhibitor",0.32026,0.83,0.631,124,0.883,"papaverine, enoximone",0.199970640755866,0.0540392964224314,FALSE +"H1650","Pearson.est","PI3K inhibitor",0.33419,0.858,0.63,75,0.897,"PI.103, PKI.179, BGT226, LY3023414, NVP.BEZ235",0.200659450546418,0.0472075569559079,FALSE +"H1650","Pearson.est","PLK inhibitor",0.36364,0.936,0.524,924,0.929,"HMN.214, BI.2536, volasertib, NMS.1286937, GSK461364, rigosertib, GW.843682X",0.280668713016273,0.0319842860063582,FALSE +"H1650","Pearson.est","potassium channel blocker",0.51775,1.32,0.181,460,1,"ibutilide, ML133, dofetilide, mepivacaine, oleoylethanolamide",0.742321425130815,0,FALSE +"H1650","Pearson.est","PPAR receptor agonist",-0.32692,-0.852,0.634,1069,0.955,"S26948, clofibrate, fenofibrate",0.197910742118267,0.0199966284162537,FALSE +"H1650","Pearson.est","progesterone receptor agonist",-0.62857,-1.62,0.0482,1125,0.486,"norgestrel, dienogest, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",1.31695296176115,0.313363730737707,FALSE +"H1650","Pearson.est","proteasome inhibitor",0.48962,1.28,0.165,391,0.919,"ONX.0914, MG.132, delanzomib, carfilzomib",0.782516055786094,0.0366844886138887,FALSE +"H1650","Pearson.est","protein synthesis inhibitor",0.29468,0.769,0.739,511,0.897,"clofoctol, cycloheximide, puromycin, thiostrepton, brefeldin.a, azomycin..2.nitroimidazole., methacycline, chloramphenicol.palmitate, anguidine, homoharringtonine",0.131355561605174,0.0472075569559079,FALSE +"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.3377,0.885,0.584,359,0.912,"AV.412, NVP.TAE226, mubritinib, tyrphostin.A9, PP.121",0.233587152887601,0.0400051616715838,FALSE +"H1650","Pearson.est","RAF inhibitor",0.45185,1.16,0.288,510,0.767,"SB.590885, vemurafenib, sorafenib, LGX818, dabrafenib, AZ.628, regorafenib, PLX.4720",0.540607512240769,0.115204636051019,FALSE +"H1650","Pearson.est","RET tyrosine kinase inhibitor",-0.36016,-0.931,0.522,1380,0.891,"sunitinib",0.282329496997738,0.0501222959631252,FALSE +"H1650","Pearson.est","retinoid receptor agonist",0.32134,0.828,0.655,68,0.857,"LE.135",0.183758700008217,0.0670191780768018,FALSE +"H1650","Pearson.est","ribonucleotide reductase inhibitor",-0.38685,-0.999,0.446,1440,0.931,"pentostatin",0.350665141287858,0.0310503190186574,FALSE +"H1650","Pearson.est","serotonin receptor agonist",-0.72827,-1.91,0.00416,1252,0.203,"NAN.190, ipsapirone, zolmitriptan, aripiprazole",2.38090666937326,0.692503962086787,TRUE +"H1650","Pearson.est","serotonin receptor antagonist",-0.44543,-1.17,0.262,1306,0.943,"ziprasidone, lurasidone, aripiprazole",0.581698708680255,0.0254883072626717,FALSE +"H1650","Pearson.est","sodium channel blocker",0.34018,0.878,0.593,425,0.888,"brivaracetam, butamben, ajmaline, cibenzoline, mexiletine, mepivacaine",0.226945306635737,0.051587034221399,FALSE +"H1650","Pearson.est","src inhibitor",-0.26593,-0.696,0.804,1415,0.922,"masitinib",0.0947439512515487,0.0352690789463706,FALSE +"H1650","Pearson.est","sterol demethylase inhibitor",-0.36614,-0.95,0.522,1237,0.884,"sulconazole, posaconazole, ketoconazole",0.282329496997738,0.0535477349869269,FALSE +"H1650","Pearson.est","TGF beta receptor inhibitor",-0.5475,-1.39,0.135,971,0.607,"repsox, SB.431542, adaprev, SB.525334, D.4476",0.869666231504994,0.216811308924742,FALSE +"H1650","Pearson.est","thymidylate synthase inhibitor",-0.32802,-0.853,0.609,473,0.987,"doxifluridine, ftorafur, raltitrexed, carmofur, capecitabine, trifluridine",0.215382707367125,0.00568284733036327,FALSE +"H1650","Pearson.est","topoisomerase inhibitor",0.23345,0.604,0.918,169,0.942,"mitoxantrone, exatecan.mesylate, idarubicin, doxorubicin",0.0371573187987575,0.0259490972071227,FALSE +"H1650","Pearson.est","tubulin polymerization inhibitor",0.46271,1.21,0.248,488,0.923,"epothilone.b, oxibendazole, mebendazole, BNC105, CYT.997, vinorelbine, fenbendazole, taltobulin, verubulin, indibulin, dolastatin.10, parbendazole, plinabulin, combretastatin.A.4, KX2.391, podophyllotoxin",0.605548319173784,0.0347982989740879,FALSE +"H1650","Pearson.est","tyrosine kinase inhibitor",0.27847,0.724,0.78,449,0.833,"AV.412, dasatinib, bafetinib, NVP.TAE226, sorafenib, mubritinib, tyrphostin.A9, PP.121, tivantinib, aminopurvalanol.a, vandetanib",0.10790539730952,0.0793549985932124,FALSE +"H1650","Pearson.est","VEGFR inhibitor",0.21312,0.534,0.952,106,0.965,"BMS.690514, XL.647, SAR131675, OSI.930",0.0213630516155257,0.0154726866562074,FALSE +"H1650","Pearson.est","vitamin D receptor agonist",0.48954,1.27,0.197,586,0.843,"calcitriol, ercalcitriol, maxacalcitol, tacalcitol, doxercalciferol",0.705533773838407,0.0741724253752577,FALSE +"HCC95","Pearson.est","EGFR inhibitor",0.39045,1.02,0.417,296,0.908,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, erlotinib, BMS.690514, WZ.3146, XL.647, AST.1306, canertinib, gefitinib, icotinib, BIBU.1361, brigatinib, BIBX.1382, PD.168393",0.379863945026242,0.0419141514789149,FALSE +"HCC95","Pearson.est","Abl kinase inhibitor",-0.27286,-0.695,0.829,1174,0.968,"ponatinib, KW.2449, imatinib, flumatinib",0.0814454694497265,0.0141246426916063,FALSE +"HCC95","Pearson.est","acetylcholine receptor agonist",0.29493,0.777,0.73,325,0.916,"xanomeline, oxiracetam",0.136677139879544,0.0381045263321496,FALSE +"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.70559,-1.91,0.0164,1313,0.217,"dicycloverine, methscopolamine, iododexetimide",1.7851561519523,0.66354026615147,TRUE +"HCC95","Pearson.est","adenosine receptor antagonist",0.31168,0.809,0.677,172,0.962,"theophylline, PSB.1115",0.169411331314856,0.0168249279621871,FALSE +"HCC95","Pearson.est","adrenergic receptor agonist",-0.3712,-0.979,0.43,1402,0.962,"norepinephrine, isoetharine",0.366531544420413,0.0168249279621871,FALSE +"HCC95","Pearson.est","adrenergic receptor antagonist",0.29737,0.766,0.724,135,0.903,"practolol, propranolol, idazoxan",0.140261433802853,0.0443122496864942,FALSE +"HCC95","Pearson.est","AKT inhibitor",0.35332,0.916,0.509,366,0.866,"MK.2206, palomid.529, AT7867, ONC201, triciribine",0.293282217663241,0.0624821079826534,FALSE +"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.36842,-0.993,0.44,1218,0.973,"alectinib, CEP.37440, DMH1",0.356547323513813,0.0118871597316481,FALSE +"HCC95","Pearson.est","androgen receptor antagonist",-0.71887,-1.86,0.00641,1160,0.155,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",2.19314197048118,0.809668301829709,TRUE +"HCC95","Pearson.est","antioxidant",-0.64067,-1.65,0.0379,1100,0.354,"benfotiamine, trolox",1.42136079003193,0.450996737974212,FALSE +"HCC95","Pearson.est","AP inhibitor",0.59967,1.54,0.0766,49,0.889,"birinapant, GDC.0152",1.1157712303674,0.0510982390297863,FALSE +"HCC95","Pearson.est","ATPase inhibitor",0.43523,1.11,0.35,281,1,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin....",0.455931955649724,0,FALSE +"HCC95","Pearson.est","Aurora kinase inhibitor",0.25077,0.632,0.901,291,0.941,"MK.5108, barasertib.HQPA, MK.8745, barasertib, ENMD.2076, alisertib",0.045275209020937,0.0264103765727431,FALSE +"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.40285,-1.06,0.377,1328,0.951,"azalomycin.b, dirithromycin",0.423658649794207,0.0218194830625861,FALSE +"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.40919,1.05,0.397,375,1,"lomefloxacin, finafloxacin, novobiocin, trovafloxacin",0.401209493236885,0,FALSE +"HCC95","Pearson.est","BCL inhibitor",-0.41438,-1.1,0.319,1416,1,"gossypol, ABT.737",0.496209316942819,0,FALSE +"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",0.2699,0.688,0.812,256,0.932,"dasatinib, metatinib, bafetinib",0.0904439707588247,0.0305840876460186,FALSE +"HCC95","Pearson.est","benzodiazepine receptor agonist",0.46636,1.22,0.245,92,0.978,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.610833915635468,0.00966114521239857,FALSE +"HCC95","Pearson.est","bromodomain inhibitor",-0.38818,-1.01,0.422,1165,0.975,"I.BET151, PFI.1",0.374687549038326,0.0109953843014632,FALSE +"HCC95","Pearson.est","calcium channel blocker",-0.26303,-0.693,0.823,1123,0.946,"efonidipine.monoethanolate, SR.33805, mibefradil",0.0846001647877302,0.0241088635982073,FALSE +"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.24636,-0.652,0.87,355,0.951,"ZK811752, UNBS.5162, MK.0812, RS.504393, SB.225002, PF.04136309, navarixin",0.0604807473813815,0.0218194830625861,FALSE +"HCC95","Pearson.est","CDK inhibitor",-0.27016,-0.714,0.821,942,0.991,"AZD5438, PHA.848125, arcyriaflavin.a, R547, palbociclib, indirubin, abemaciclib, JNJ.7706621, BMS.265246, ribociclib, TG.02",0.0856568428805592,0.00392634551472468,FALSE +"HCC95","Pearson.est","CHK inhibitor",-0.50632,-1.31,0.177,1202,0.814,"SCH.900776, AZD7762, SB.218078",0.752026733638193,0.0893755951107988,FALSE +"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.42313,-1.12,0.314,1260,1,"AM.404, tryptanthrin, acetylsalicylsalicylic.acid, piroxicam, FR.122047, naproxen",0.503070351926785,0,FALSE +"HCC95","Pearson.est","cytochrome P450 inhibitor",0.57473,1.46,0.0951,262,0.953,"PF.4981517, morin, eplerenone",1.02181948306259,0.0209070993616736,FALSE +"HCC95","Pearson.est","DNA alkylating agent",-0.43799,-1.16,0.253,1117,1,"melphalan, carmustine, mitomycin.c, streptozotocin, satraplatin, temozolomide, cyclophosphamide",0.596879478824182,0,FALSE +"HCC95","Pearson.est","DNA inhibitor",-0.24957,-0.663,0.852,1117,0.962,"melphalan, carmustine, busulfan, nithiamide, pibenzimol",0.0695604052332999,0.0168249279621871,FALSE +"HCC95","Pearson.est","DNA methyltransferase inhibitor",0.46339,1.2,0.278,551,0.936,"SGI.1027, fdcyd, azacitidine, decitabine",0.555955204081924,0.0287241512618947,FALSE +"HCC95","Pearson.est","DNA polymerase inhibitor",0.4034,1.02,0.408,300,0.908,"foscarnet, cephalomannine, cidofovir, idoxuridine",0.38933983691012,0.0419141514789149,FALSE +"HCC95","Pearson.est","DNA synthesis inhibitor",-0.24103,-0.625,0.9,1437,0.958,"enocitabine",0.0457574905606751,0.0186344909214556,FALSE +"HCC95","Pearson.est","dopamine receptor antagonist",-0.34135,-0.908,0.533,1150,0.93,"mesoridazine, remoxipride, ziprasidone, paliperidone, lurasidone, amisulpride",0.273272790973428,0.0315170514460649,FALSE +"HCC95","Pearson.est","estrogen receptor agonist",-0.28523,-0.745,0.77,1404,0.969,"erteberel",0.113509274827518,0.0136762229492347,FALSE +"HCC95","Pearson.est","estrogen receptor antagonist",-0.83815,-2.15,0,1333,0.0504,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.29756946355447,TRUE +"HCC95","Pearson.est","FGFR inhibitor",-0.30717,-0.815,0.632,1074,0.928,"MK.2461, nintedanib, lenvatinib, lucitanib",0.199282921717615,0.0324520237811379,FALSE +"HCC95","Pearson.est","FLT3 inhibitor",-0.39654,-1.03,0.411,1174,0.974,"ponatinib, KW.2449, pacritinib, quizartinib, TG.02, sunitinib, lestaurtinib",0.386158178123931,0.0114410431213845,FALSE +"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.36764,-0.966,0.473,980,0.909,"triamcinolone.acetonide, rimexolone, halcinonide, fludroxycortide, prednisolone, flumethasone, triamcinolone, prednisolone.acetate, piretanide, beclomethasone.dipropionate, fluticasone.propionate, fluocinolone.acetonide, hydrocortisone, flumethasone.pivalate, dexamethasone.acetate",0.325138859262188,0.0414361167780325,FALSE +"HCC95","Pearson.est","glutamate receptor antagonist",0.33886,0.842,0.637,349,0.974,"ACDPP, tiletamine, kynurenic.acid, CGP.37849",0.19586056766465,0.0114410431213845,FALSE +"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.40081,1.05,0.367,36,1,"CHIR.99021",0.435333935747911,0,FALSE +"HCC95","Pearson.est","growth factor receptor inhibitor",-0.64846,-1.68,0.0477,1254,0.367,"GSK1838705A, GW.441756, lestaurtinib",1.32148162095989,0.435333935747911,FALSE +"HCC95","Pearson.est","HCV inhibitor",0.55748,1.45,0.0975,44,0.794,"daclatasvir",1.01099538430146,0.100179497572904,FALSE +"HCC95","Pearson.est","HDAC inhibitor",0.4075,1.05,0.393,378,1,"nexturastat.a, panobinostat, chidamide, belinostat, NSC.3852, scriptaid, SB.939, ACY.1215, entinostat, M.344, resminostat",0.405607449624573,0,FALSE +"HCC95","Pearson.est","histamine receptor antagonist",-0.23231,-0.608,0.895,1242,0.953,"tiotidine, ebastine, epinastine, BF2.649",0.048176964684088,0.0209070993616736,FALSE +"HCC95","Pearson.est","HMGCR inhibitor",0.5215,1.35,0.152,310,0.826,"atorvastatin, simvastatin, pitavastatin",0.818156412055227,0.0830199526796178,FALSE +"HCC95","Pearson.est","HSP inhibitor",0.48376,1.26,0.202,326,0.972,"BIIB021, NMS.E973, PU.H71, SNX.5422, SNX.2112, NVP.AUY922, ganetespib, KW.2478",0.694648630553376,0.0123337350737254,FALSE +"HCC95","Pearson.est","JAK inhibitor",-0.34799,-0.933,0.505,998,0.91,"AT.9283, PRT062070, TG.101348, CEP.33779, AZD1480, filgotinib, pacritinib, TG.02, lestaurtinib",0.296708621881339,0.0409586076789064,FALSE +"HCC95","Pearson.est","KIT inhibitor",-0.37258,-0.962,0.498,1175,0.881,"lenvatinib, KI.8751, imatinib, telatinib, vatalanib, sunitinib, masitinib",0.302770657240282,0.0550240915879521,FALSE +"HCC95","Pearson.est","MDM inhibitor",0.21012,0.54,0.965,1145,0.96,"serdemetan, idasanutlin, AMG.232, nutlin.3, CGM097, RITA",0.0154726866562074,0.0177287669604316,FALSE +"HCC95","Pearson.est","MEK inhibitor",-0.30583,-0.818,0.678,1284,0.951,"nobiletin, MEK162, BIX.02188, arctigenin",0.168770306132937,0.0218194830625861,FALSE +"HCC95","Pearson.est","MET inhibitor",-0.71135,-1.87,0.0128,1233,0.188,"INC.280, PHA.665752, AMG458, NVP.BVU972",1.89279003035213,0.72584215073632,TRUE +"HCC95","Pearson.est","microtubule inhibitor",0.37755,0.98,0.467,182,0.898,"estramustine.phosphate, triclabendazole",0.330683119433888,0.0467236633326956,FALSE +"HCC95","Pearson.est","mTOR inhibitor",0.68759,1.73,0.00916,332,0.937,"deforolimus, PI.103, AZD8055, PKI.179, torin.1, everolimus, LY3023414, NVP.BEZ235, temsirolimus, MLN0128, PP242, AZD2014, GDC.0980, WYE.125132, torin.2, sirolimus, SB.2343, voxtalisib, palomid.529, PF.04691502",2.03810452633215,0.0282604091122217,FALSE +"HCC95","Pearson.est","NFkB pathway inhibitor",-0.42576,-1.09,0.349,1079,0.981,"IKK.2.inhibitor.V, curcumin, bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.45717457304082,0.0083309926200515,FALSE +"HCC95","Pearson.est","opioid receptor agonist",-0.41695,-1.1,0.345,1262,1,"ADL5859, salvinorin.a",0.462180904926726,0,FALSE +"HCC95","Pearson.est","p38 MAPK inhibitor",-0.22533,-0.584,0.94,896,0.951,"talmapimod, CMPD.1, TAK.715, skepinone.l",0.0268721464003014,0.0218194830625861,FALSE +"HCC95","Pearson.est","PARP inhibitor",-0.54924,-1.47,0.0954,972,0.511,"niraparib, olaparib, AZD2461, AG.14361, talazoparib",1.0204516252959,0.291579099865287,FALSE +"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.45414,-1.19,0.235,1130,1,"nintedanib, ponatinib, lenvatinib, KI.8751, axitinib, imatinib, telatinib, vatalanib, CP.673451, sunitinib, masitinib",0.628932137728264,0,FALSE +"HCC95","Pearson.est","phosphatase inhibitor",-0.29123,-0.786,0.676,1177,0.927,"menadione, CID.5458317, alexidine",0.170053304058364,0.0329202658555029,FALSE +"HCC95","Pearson.est","phosphodiesterase inhibitor",0.27143,0.714,0.781,275,0.924,"papaverine, enoximone, EMD.53998",0.1073489661227,0.0343280287798933,FALSE +"HCC95","Pearson.est","PI3K inhibitor",0.3149,0.796,0.694,90,0.915,"PI.103, PKI.179, BGT226, LY3023414, NVP.BEZ235",0.158640529545145,0.0385789059335517,FALSE +"HCC95","Pearson.est","PLK inhibitor",0.31437,0.808,0.694,995,0.928,"HMN.214, BI.2536, NMS.1286937, volasertib, rigosertib, GSK461364, GW.843682X",0.158640529545145,0.0324520237811379,FALSE +"HCC95","Pearson.est","potassium channel blocker",0.63103,1.63,0.0472,422,0.856,"ML133, ibutilide, oleoylethanolamide, dofetilide, mepivacaine",1.32605800136591,0.0675262353228468,FALSE +"HCC95","Pearson.est","PPAR receptor agonist",-0.26982,-0.71,0.814,979,0.971,"GW.501516, S26948, clofibrate, fenofibrate",0.0893755951107988,0.0127807700919951,FALSE +"HCC95","Pearson.est","progesterone receptor agonist",-0.61232,-1.62,0.0552,1148,0.347,"dienogest, norgestrel, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",1.2580609222708,0.459670525209126,FALSE +"HCC95","Pearson.est","proteasome inhibitor",0.39475,1.02,0.418,183,0.908,"ONX.0914, MG.132",0.378823718224965,0.0419141514789149,FALSE +"HCC95","Pearson.est","protein synthesis inhibitor",0.29296,0.761,0.732,421,0.882,"clofoctol, cycloheximide, brefeldin.a, thiostrepton, puromycin, methacycline, azomycin..2.nitroimidazole., chloramphenicol.palmitate",0.135488918941608,0.0545314148681803,FALSE +"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.32526,-0.86,0.587,1331,0.966,"CP.724714, rheochrysidin",0.231361898752386,0.0150228735845067,FALSE +"HCC95","Pearson.est","RAF inhibitor",0.38643,0.99,0.446,368,0.925,"SB.590885, vemurafenib, dabrafenib, sorafenib, LGX818",0.350665141287858,0.0338582672609674,FALSE +"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.40723,-1.08,0.38,1410,0.949,"sunitinib",0.42021640338319,0.0227337875727074,FALSE +"HCC95","Pearson.est","retinoid receptor agonist",-0.30082,-0.806,0.696,1056,0.918,"CD.437, adarotene, AM.580",0.157390760389438,0.0371573187987575,FALSE +"HCC95","Pearson.est","ribonucleotide reductase inhibitor",-0.36759,-0.976,0.455,1439,0.926,"pentostatin",0.341988603342888,0.0333890133180656,FALSE +"HCC95","Pearson.est","serotonin receptor agonist",-0.32309,-0.832,0.658,1142,0.987,"NAN.190, ipsapirone, zolmitriptan",0.181774106386044,0.00568284733036327,FALSE +"HCC95","Pearson.est","serotonin receptor antagonist",0.32578,0.84,0.652,342,0.939,"SB.200646, sertindole, aripiprazole, lerisetron, SB.228357, pirenperone",0.18575240426808,0.0273344077338891,FALSE +"HCC95","Pearson.est","sodium channel blocker",0.36806,0.937,0.519,426,0.904,"brivaracetam, ajmaline, cibenzoline, butamben, mepivacaine, mexiletine",0.284832642151542,0.0438315695246367,FALSE +"HCC95","Pearson.est","src inhibitor",-0.34274,-0.9,0.559,1278,0.914,"PP.2, masitinib",0.252588192113577,0.0390538042661686,FALSE +"HCC95","Pearson.est","sterol demethylase inhibitor",0.36519,0.944,0.493,13,0.934,"chlormidazole",0.30715308072277,0.0296531237699066,FALSE +"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.57606,-1.49,0.107,1020,0.532,"SB.431542, adaprev, repsox, D.4476, SB.525334",0.97061622231479,0.274088367704952,FALSE +"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.31623,-0.82,0.649,456,0.978,"ftorafur, raltitrexed, carmofur, doxifluridine, capecitabine, trifluridine",0.187755303199631,0.00966114521239857,FALSE +"HCC95","Pearson.est","topoisomerase inhibitor",0.25312,0.653,0.877,174,0.946,"mitoxantrone, idarubicin, doxorubicin, exatecan.mesylate",0.0570004066339595,0.0241088635982073,FALSE +"HCC95","Pearson.est","tubulin polymerization inhibitor",0.36216,0.925,0.532,544,0.888,"mebendazole, epothilone.b, BNC105, oxibendazole, vinorelbine, CYT.997, indibulin, taltobulin, fenbendazole, verubulin, KX2.391, dolastatin.10, plinabulin, parbendazole, podophyllotoxin",0.274088367704952,0.051587034221399,FALSE +"HCC95","Pearson.est","tyrosine kinase inhibitor",0.23237,0.593,0.912,470,0.949,"dasatinib, AV.412, mubritinib, NVP.TAE226, bafetinib, GTP.14564, sorafenib, vandetanib, tyrphostin.A9, tivantinib, apatinib",0.0400051616715838,0.0227337875727074,FALSE +"HCC95","Pearson.est","VEGFR inhibitor",-0.20758,-0.562,0.947,1049,0.947,"AEE788, MK.2461, tivozanib, nintedanib, lenvatinib, KI.8751, axitinib, lucitanib, foretinib, telatinib, vatalanib, sunitinib",0.0236500209967266,0.0236500209967266,FALSE +"HCC95","Pearson.est","vitamin D receptor agonist",0.54269,1.4,0.134,465,0.805,"ercalcitriol, calcitriol, maxacalcitol, tacalcitol",0.872895201635192,0.0942041196321315,FALSE +"H3255","Pearson.est","EGFR inhibitor",0.47647,1.22,0.232,368,1,"CUDC.101, ARRY.334543, BMS.690514, erlotinib, tyrphostin.AG.1478, XL.647, canertinib, WZ.3146, gefitinib, brigatinib, AST.1306, BIBU.1361, PD.168393, icotinib, BIBX.1382, AZD8931, lapatinib, afatinib, rociletinib, pelitinib, osimertinib",0.6345120151091,0,FALSE +"H3255","Pearson.est","Abl kinase inhibitor",0.33791,0.856,0.631,232,0.881,"dasatinib, metatinib, bafetinib",0.199970640755866,0.0550240915879521,FALSE +"H3255","Pearson.est","acetylcholine receptor agonist",0.29605,0.757,0.74,306,0.853,"xanomeline, oxiracetam",0.130768280269024,0.069050968832477,FALSE +"H3255","Pearson.est","acetylcholine receptor antagonist",-0.76141,-2.01,0,1309,0.0687,"dicycloverine, methscopolamine, iododexetimide",Inf,1.16304326294045,TRUE +"H3255","Pearson.est","adenosine receptor antagonist",0.3399,0.884,0.582,173,0.861,"theophylline, PSB.1115",0.235077015350112,0.0649968485463452,FALSE +"H3255","Pearson.est","adrenergic receptor agonist",-0.39644,-1.06,0.345,1247,0.986,"methyldopa, ritodrine, norepinephrine, isoetharine",0.462180904926726,0.0061230850587888,FALSE +"H3255","Pearson.est","adrenergic receptor antagonist",0.37475,0.961,0.471,167,0.886,"practolol, idazoxan, propranolol, vincamine",0.326979092871104,0.0525662781129492,FALSE +"H3255","Pearson.est","AKT inhibitor",0.44547,1.12,0.327,341,0.987,"triciribine, MK.2206, AT7867, ONC201, palomid.529",0.485452247339714,0.00568284733036327,FALSE +"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27517,-0.73,0.791,1187,0.883,"alectinib, CEP.37440, DMH1",0.101823516502323,0.0540392964224314,FALSE +"H3255","Pearson.est","androgen receptor antagonist",-0.74927,-2.01,0.00642,1212,0.0687,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",2.19246497193115,1.16304326294045,TRUE +"H3255","Pearson.est","antioxidant",-0.57031,-1.5,0.0708,1114,0.485,"benfotiamine, trolox",1.14996674231023,0.314258261397736,FALSE +"H3255","Pearson.est","AP inhibitor",0.60776,1.57,0.0627,81,0.807,"birinapant, GDC.0152",1.20273245916928,0.0931264652779296,FALSE +"H3255","Pearson.est","ATPase inhibitor",0.3926,1.01,0.431,498,0.907,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873, thonzonium, digoxin",0.365522729839268,0.0423927129399047,FALSE +"H3255","Pearson.est","Aurora kinase inhibitor",0.38544,0.988,0.447,464,0.866,"barasertib, barasertib.HQPA, MK.8745, alisertib, MK.5108, ENMD.2076, ZM.447439, PF.03814735, CCT137690, danusertib, SNS.314",0.349692476868064,0.0624821079826534,FALSE +"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.27758,-0.733,0.774,1244,0.902,"azalomycin.b, dirithromycin",0.111259039317107,0.0447934624580583,FALSE +"H3255","Pearson.est","bacterial DNA gyrase inhibitor",0.35823,0.935,0.507,393,0.863,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.294992040666664,0.0639892042847904,FALSE +"H3255","Pearson.est","BCL inhibitor",-0.37109,-0.959,0.464,1398,1,"gossypol, ABT.737",0.333482019445119,0,FALSE +"H3255","Pearson.est","Bcr.Abl kinase inhibitor",0.39713,1.02,0.386,232,0.99,"dasatinib, metatinib, bafetinib",0.413412695328245,0.00436480540245009,FALSE +"H3255","Pearson.est","benzodiazepine receptor agonist",0.41276,1.06,0.378,129,1,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.422508200162775,0,FALSE +"H3255","Pearson.est","bromodomain inhibitor",-0.42149,-1.08,0.348,1180,1,"I.BET151, PFI.1",0.458420756053419,0,FALSE +"H3255","Pearson.est","calcium channel blocker",-0.34179,-0.891,0.556,1111,1,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.254925208417942,0,FALSE +"H3255","Pearson.est","CC chemokine receptor antagonist",-0.28938,-0.75,0.755,417,0.901,"ZK811752, MK.0812, UNBS.5162, RS.504393, SB.225002, navarixin, PF.04136309",0.122053048370812,0.045275209020937,FALSE +"H3255","Pearson.est","CDK inhibitor",-0.15919,-0.415,0.998,227,0.996,"alvocidib, NU6027, CR8..R., kenpaullone, AT.7519, dinaciclib, P276.00, aminopurvalanol.a, indisulam, PHA.793887, BMS.387032, palbociclib, arcyriaflavin.a, PHA.848125, R547, AZD5438, abemaciclib, indirubin, ribociclib, JNJ.7706621, BMS.265246, TG.02",0.000869458712628891,0.00174066157630127,FALSE +"H3255","Pearson.est","CHK inhibitor",-0.49896,-1.31,0.179,1174,0.751,"SCH.900776, AZD7762, SB.218078",0.747146969020107,0.124360062995832,FALSE +"H3255","Pearson.est","cyclooxygenase inhibitor",-0.40463,-1.08,0.358,1231,1,"acetylsalicylsalicylic.acid, AM.404, tryptanthrin, FR.122047, piroxicam, naproxen",0.446116973356126,0,FALSE +"H3255","Pearson.est","cytochrome P450 inhibitor",0.5224,1.32,0.17,295,0.989,"PF.4981517, morin, eplerenone",0.769551078621726,0.0048037084028206,FALSE +"H3255","Pearson.est","DNA alkylating agent",-0.3224,-0.885,0.586,1045,0.984,"streptozotocin, carmustine, melphalan, satraplatin, cyclophosphamide, temozolomide",0.232102383981909,0.00700490156865849,FALSE +"H3255","Pearson.est","DNA inhibitor",-0.24169,-0.642,0.868,1358,0.948,"pibenzimol, nithiamide",0.0614802748235081,0.0231916626619338,FALSE +"H3255","Pearson.est","DNA methyltransferase inhibitor",0.65378,1.69,0.0331,411,0.609,"SGI.1027, azacitidine, decitabine, fdcyd",1.48017200622428,0.215382707367125,FALSE +"H3255","Pearson.est","DNA polymerase inhibitor",0.46659,1.18,0.266,171,1,"foscarnet, cidofovir, cephalomannine, idoxuridine",0.575118363368933,0,FALSE +"H3255","Pearson.est","DNA synthesis inhibitor",-0.32865,-0.864,0.607,1388,0.955,"altretamine, enocitabine",0.216811308924742,0.0199966284162537,FALSE +"H3255","Pearson.est","dopamine receptor antagonist",-0.34498,-0.907,0.54,1188,1,"ziprasidone, paliperidone, remoxipride, lurasidone, amisulpride",0.267606240177031,0,FALSE +"H3255","Pearson.est","estrogen receptor agonist",-0.33647,-0.864,0.616,1126,0.955,"ethinyl.estradiol, estrone, erteberel",0.210419287835575,0.0199966284162537,FALSE +"H3255","Pearson.est","estrogen receptor antagonist",-0.78386,-2.1,0.00233,1287,0.0939,"danazol, raloxifene, fulvestrant, tamoxifen",2.63264407897398,1.02733440773389,TRUE +"H3255","Pearson.est","FGFR inhibitor",-0.22949,-0.607,0.923,330,0.959,"orantinib, AZD4547, regorafenib, erdafitinib, PD.173074, dovitinib, nintedanib, MK.2461, lenvatinib, lucitanib",0.0347982989740879,0.0181813928293364,FALSE +"H3255","Pearson.est","FLT3 inhibitor",-0.3107,-0.826,0.668,1171,0.935,"TG.101348, KW.2449, quizartinib, TG.02, sunitinib, lestaurtinib",0.175223537524454,0.0291883891274822,FALSE +"H3255","Pearson.est","glucocorticoid receptor agonist",-0.35685,-0.948,0.502,956,1,"flumethasone, desonide, halcinonide, triamcinolone.acetonide, rimexolone, fludroxycortide, prednisolone, triamcinolone, beclomethasone.dipropionate, prednisolone.acetate, fluticasone.propionate, fluocinolone.acetonide, piretanide, dexamethasone.acetate, flumethasone.pivalate, hydrocortisone",0.299296282854981,0,FALSE +"H3255","Pearson.est","glutamate receptor antagonist",0.30336,0.758,0.77,258,0.877,"ACDPP, tiletamine, kynurenic.acid",0.113509274827518,0.0570004066339595,FALSE +"H3255","Pearson.est","glycogen synthase kinase inhibitor",0.37363,0.96,0.456,31,0.85,"CHIR.99021",0.341035157335565,0.0705810742857073,FALSE +"H3255","Pearson.est","growth factor receptor inhibitor",-0.51585,-1.36,0.148,1176,0.709,"GSK1838705A, GW.441756, lestaurtinib",0.829738284605043,0.149353764816933,FALSE +"H3255","Pearson.est","HCV inhibitor",0.40114,1.02,0.435,63,0.99,"daclatasvir",0.361510743045363,0.00436480540245009,FALSE +"H3255","Pearson.est","HDAC inhibitor",0.46123,1.16,0.263,407,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, M.344, ACY.1215, entinostat, resminostat, mocetinostat, romidepsin, givinostat",0.580044251510242,0,FALSE +"H3255","Pearson.est","histamine receptor antagonist",-0.25592,-0.671,0.829,1103,0.938,"cyproheptadine, terfenadine, tiotidine, ranitidine, ebastine, BF2.649, epinastine",0.0814454694497265,0.0277971616209356,FALSE +"H3255","Pearson.est","HMGCR inhibitor",0.31895,0.808,0.686,257,0.875,"atorvastatin, simvastatin",0.163675884293248,0.0579919469776868,FALSE +"H3255","Pearson.est","HSP inhibitor",0.56564,1.45,0.0994,216,0.709,"BIIB021, NMS.E973, PU.H71, NVP.AUY922, SNX.2112, ganetespib, SNX.5422",1.00261361560269,0.149353764816933,FALSE +"H3255","Pearson.est","JAK inhibitor",-0.31267,-0.84,0.609,1171,0.971,"TG.101348, filgotinib, AZD1480, CEP.33779, TG.02, lestaurtinib",0.215382707367125,0.0127807700919951,FALSE +"H3255","Pearson.est","KIT inhibitor",0.29528,0.765,0.75,80,0.892,"midostaurin, OSI.930, dasatinib",0.1249387366083,0.0496351456238769,FALSE +"H3255","Pearson.est","MDM inhibitor",-0.29196,-0.768,0.744,421,0.898,"serdemetan, idasanutlin, AMG.232, nutlin.3, CGM097, RITA",0.128427064454121,0.0467236633326956,FALSE +"H3255","Pearson.est","MEK inhibitor",-0.30982,-0.831,0.641,1197,0.957,"refametinib, nobiletin, MEK162, arctigenin, BIX.02188",0.193141970481183,0.0190880622231565,FALSE +"H3255","Pearson.est","MET inhibitor",-0.61545,-1.6,0.0516,1144,0.422,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.28735029837279,0.374687549038326,FALSE +"H3255","Pearson.est","microtubule inhibitor",0.42306,1.11,0.312,151,0.942,"estramustine.phosphate, triclabendazole",0.505845405981557,0.0259490972071227,FALSE +"H3255","Pearson.est","mTOR inhibitor",0.69455,1.78,0.0156,190,0.677,"deforolimus, PI.103, AZD8055, PKI.179, everolimus, torin.1, NVP.BEZ235, temsirolimus, MLN0128, LY3023414, AZD2014, PP242, GDC.0980, WYE.125132, sirolimus, torin.2",1.80687540164554,0.169411331314856,FALSE +"H3255","Pearson.est","NFkB pathway inhibitor",-0.40553,-1.08,0.332,1039,1,"curcumin, tyloxapol, IKK.2.inhibitor.V, Ro.106.9920, bindarit, parthenolide, betulinic.acid",0.478861916295964,0,FALSE +"H3255","Pearson.est","opioid receptor agonist",-0.41123,-1.07,0.357,1268,1,"ADL5859, salvinorin.a",0.447331783887807,0,FALSE +"H3255","Pearson.est","p38 MAPK inhibitor",-0.21056,-0.556,0.945,1150,0.974,"TAK.715, skepinone.l",0.0245681914907371,0.0114410431213845,FALSE +"H3255","Pearson.est","PARP inhibitor",-0.59429,-1.56,0.0751,1033,0.432,"niraparib, AZD2461, olaparib, AG.14361, talazoparib",1.12436006299583,0.364516253185088,FALSE +"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.29832,-0.813,0.649,1116,0.872,"lenvatinib, KI.8751, axitinib, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.187755303199631,0.0594835150674328,FALSE +"H3255","Pearson.est","phosphatase inhibitor",-0.30875,-0.796,0.688,1159,0.876,"CID.5458317, menadione, alexidine",0.162411561764489,0.0574958938319193,FALSE +"H3255","Pearson.est","phosphodiesterase inhibitor",0.27198,0.689,0.825,259,0.873,"papaverine, enoximone, EMD.53998",0.0835460514500749,0.0589857562944303,FALSE +"H3255","Pearson.est","PI3K inhibitor",0.38613,1,0.451,493,0.884,"PI.103, PKI.179, NVP.BEZ235, BGT226, LY3023414, GDC.0980, voxtalisib, SB.2343, PF.04691502, ZSTK.474, buparlisib, PF.05212384, PI3K.IN.2, CUDC.907, PI.828",0.345823458122039,0.0535477349869269,FALSE +"H3255","Pearson.est","PLK inhibitor",0.36849,0.922,0.532,917,0.82,"HMN.214, BI.2536, volasertib, NMS.1286937, rigosertib, GSK461364, GW.843682X",0.274088367704952,0.0861861476162833,FALSE +"H3255","Pearson.est","potassium channel blocker",0.5926,1.51,0.0622,423,0.813,"ML133, ibutilide, oleoylethanolamide, mepivacaine, dofetilide",1.20620961530918,0.0899094544059319,FALSE +"H3255","Pearson.est","PPAR receptor agonist",-0.31467,-0.823,0.681,968,0.911,"GW.501516, S26948, clofibrate, fenofibrate",0.166852888087215,0.0404816230270017,FALSE +"H3255","Pearson.est","progesterone receptor agonist",-0.71483,-1.88,0.0129,1208,0.139,"norgestrel, melengestrol.acetate, dienogest, nomegestrol.acetate, danazol, norethindrone.acetate",1.88941028970075,0.856985199745905,TRUE +"H3255","Pearson.est","proteasome inhibitor",0.43907,1.14,0.3,146,1,"ONX.0914, MG.132",0.522878745280338,0,FALSE +"H3255","Pearson.est","protein synthesis inhibitor",0.26051,0.675,0.83,297,0.866,"clofoctol, cycloheximide, thiostrepton, puromycin, brefeldin.a",0.0809219076239261,0.0624821079826534,FALSE +"H3255","Pearson.est","protein tyrosine kinase inhibitor",0.33138,0.846,0.642,198,0.868,"AV.412, NVP.TAE226, mubritinib",0.192464971931147,0.0614802748235081,FALSE +"H3255","Pearson.est","RAF inhibitor",0.49427,1.24,0.246,338,1,"SB.590885, vemurafenib, sorafenib, LGX818, dabrafenib, AZ.628",0.609064892896621,0,FALSE +"H3255","Pearson.est","RET tyrosine kinase inhibitor",-0.30972,-0.821,0.661,1375,0.885,"sunitinib",0.17979854051436,0.0530567293021746,FALSE +"H3255","Pearson.est","retinoid receptor agonist",0.27529,0.703,0.815,102,0.878,"LE.135",0.0888423912600234,0.0565054840938974,FALSE +"H3255","Pearson.est","ribonucleotide reductase inhibitor",-0.36591,-0.978,0.462,1438,1,"pentostatin",0.335358024443874,0,FALSE +"H3255","Pearson.est","serotonin receptor agonist",-0.64949,-1.69,0.0566,1179,0.337,"NAN.190, ipsapirone, zolmitriptan, aripiprazole",1.24718356881173,0.472370099128661,FALSE +"H3255","Pearson.est","serotonin receptor antagonist",-0.3813,-1,0.422,1088,1,"RS.16566, tropisetron, ziprasidone, paliperidone, lurasidone, aripiprazole",0.374687549038326,0,FALSE +"H3255","Pearson.est","sodium channel blocker",0.31361,0.802,0.669,486,0.858,"brivaracetam, ajmaline, butamben, mepivacaine, cibenzoline, mexiletine",0.174573882232177,0.0665127121512946,FALSE +"H3255","Pearson.est","src inhibitor",-0.34036,-0.906,0.559,1294,1,"PP.2, masitinib",0.252588192113577,0,FALSE +"H3255","Pearson.est","sterol demethylase inhibitor",0.36053,0.925,0.527,10,0.847,"chlormidazole",0.278189384787453,0.0721165896692931,FALSE +"H3255","Pearson.est","TGF beta receptor inhibitor",-0.45113,-1.22,0.234,941,0.906,"repsox, adaprev, SB.431542, D.4476, SB.525334",0.630784142589857,0.0428718023231869,FALSE +"H3255","Pearson.est","thymidylate synthase inhibitor",-0.34327,-0.908,0.545,495,1,"ftorafur, raltitrexed, carmofur, doxifluridine, capecitabine, trifluridine",0.263603497723358,0,FALSE +"H3255","Pearson.est","topoisomerase inhibitor",0.27234,0.709,0.824,157,0.895,"mitoxantrone, idarubicin, exatecan.mesylate, doxorubicin",0.0840727883028842,0.048176964684088,FALSE +"H3255","Pearson.est","tubulin polymerization inhibitor",0.40052,1.01,0.423,492,0.907,"epothilone.b, mebendazole, oxibendazole, BNC105, vinorelbine, CYT.997, fenbendazole, taltobulin, verubulin, indibulin, plinabulin, parbendazole, KX2.391, dolastatin.10",0.373659632624958,0.0423927129399047,FALSE +"H3255","Pearson.est","tyrosine kinase inhibitor",0.31492,0.812,0.677,522,0.898,"dasatinib, AV.412, NVP.TAE226, mubritinib, bafetinib, sorafenib, tyrphostin.A9, GTP.14564, tivantinib, vandetanib, apatinib, PP.121, regorafenib, aminopurvalanol.a",0.169411331314856,0.0467236633326956,FALSE +"H3255","Pearson.est","VEGFR inhibitor",0.22416,0.59,0.947,118,0.927,"BMS.690514, OSI.930, XL.647, SAR131675",0.0236500209967266,0.0329202658555029,FALSE +"H3255","Pearson.est","vitamin D receptor agonist",0.57496,1.46,0.105,524,0.815,"ercalcitriol, calcitriol, maxacalcitol, tacalcitol, doxercalciferol",0.978810700930062,0.0888423912600234,FALSE +"H1648","Pearson.est","EGFR inhibitor",0.43902,1.14,0.287,414,1,"CUDC.101, ARRY.334543, BMS.690514, erlotinib, tyrphostin.AG.1478, XL.647, canertinib, WZ.3146, brigatinib, gefitinib, AST.1306, PD.168393, BIBU.1361, icotinib, AZD8931, lapatinib, pelitinib, BIBX.1382, osimertinib, afatinib, rociletinib, GW.583340, vandetanib",0.542118103266008,0,FALSE +"H1648","Pearson.est","Abl kinase inhibitor",0.33285,0.842,0.611,186,0.861,"dasatinib, metatinib, bafetinib",0.213958789757446,0.0649968485463452,FALSE +"H1648","Pearson.est","acetylcholine receptor agonist",0.2306,0.581,0.946,127,0.962,"xanomeline",0.0241088635982073,0.0168249279621871,FALSE +"H1648","Pearson.est","acetylcholine receptor antagonist",-0.7901,-2.09,0.00421,1327,0.0437,"dicycloverine, methscopolamine, iododexetimide",2.37571790416433,1.35951856302958,TRUE +"H1648","Pearson.est","adenosine receptor antagonist",0.37232,0.955,0.48,137,0.884,"theophylline, PSB.1115",0.318758762624413,0.0535477349869269,FALSE +"H1648","Pearson.est","adrenergic receptor agonist",-0.37097,-0.983,0.474,1413,0.926,"norepinephrine, isoetharine",0.324221658325915,0.0333890133180656,FALSE +"H1648","Pearson.est","adrenergic receptor antagonist",0.3527,0.908,0.562,178,0.868,"practolol, idazoxan, propranolol, vincamine",0.250263684430939,0.0614802748235081,FALSE +"H1648","Pearson.est","AKT inhibitor",0.45328,1.16,0.279,345,1,"MK.2206, triciribine, AT7867, palomid.529, ONC201",0.554395796726402,0,FALSE +"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.29754,-0.769,0.724,1169,0.91,"alectinib, CEP.37440, DMH1",0.140261433802853,0.0409586076789064,FALSE +"H1648","Pearson.est","androgen receptor antagonist",-0.74899,-1.99,0.00638,1172,0.0688,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",2.19517932127884,1.16241156176449,TRUE +"H1648","Pearson.est","antioxidant",-0.62411,-1.61,0.0678,1124,0.358,"benfotiamine, trolox",1.16877030613294,0.446116973356126,FALSE +"H1648","Pearson.est","AP inhibitor",0.64659,1.65,0.045,68,0.794,"birinapant, GDC.0152",1.34678748622466,0.100179497572904,FALSE +"H1648","Pearson.est","ATPase inhibitor",0.38965,1.03,0.381,373,0.852,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873",0.419075024324381,0.0695604052332999,FALSE +"H1648","Pearson.est","Aurora kinase inhibitor",0.26311,0.689,0.817,510,0.928,"MK.5108, barasertib.HQPA, barasertib, ENMD.2076, alisertib, MK.8745, ZM.447439, PF.03814735, CCT137690, danusertib",0.0877779434675845,0.0324520237811379,FALSE +"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.3809,-1.03,0.395,1314,1,"azalomycin.b, dirithromycin",0.40340290437354,0,FALSE +"H1648","Pearson.est","bacterial DNA gyrase inhibitor",0.34199,0.886,0.582,269,0.81,"lomefloxacin, novobiocin, finafloxacin",0.235077015350112,0.0915149811213502,FALSE +"H1648","Pearson.est","BCL inhibitor",-0.39017,-1.02,0.389,1401,1,"gossypol, ABT.737",0.410050398674292,0,FALSE +"H1648","Pearson.est","Bcr.Abl kinase inhibitor",0.40257,1.04,0.398,186,0.88,"dasatinib, metatinib, bafetinib",0.400116927926312,0.0555173278498314,FALSE +"H1648","Pearson.est","benzodiazepine receptor agonist",0.42871,1.1,0.322,108,1,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.492144128304169,0,FALSE +"H1648","Pearson.est","bromodomain inhibitor",-0.45891,-1.21,0.248,1220,0.908,"I.BET151, PFI.1",0.605548319173784,0.0419141514789149,FALSE +"H1648","Pearson.est","calcium channel blocker",-0.31662,-0.829,0.636,1080,0.941,"pranidipine, SR.33805, efonidipine.monoethanolate, mibefradil",0.196542884351586,0.0264103765727431,FALSE +"H1648","Pearson.est","CC chemokine receptor antagonist",-0.26579,-0.693,0.837,383,0.904,"ZK811752, UNBS.5162, MK.0812, RS.504393, SB.225002, navarixin, PF.04136309",0.07727454200674,0.0438315695246367,FALSE +"H1648","Pearson.est","CDK inhibitor",-0.2905,-0.762,0.719,1036,0.851,"R547, PHA.848125, AZD5438, indirubin, abemaciclib, ribociclib, JNJ.7706621, BMS.265246, TG.02",0.143271109617117,0.0700704399154121,FALSE +"H1648","Pearson.est","CHK inhibitor",-0.53591,-1.39,0.139,1193,0.605,"SCH.900776, AZD7762, SB.218078",0.856985199745905,0.218244625347531,FALSE +"H1648","Pearson.est","cyclooxygenase inhibitor",-0.38464,-1,0.414,1225,0.933,"acetylsalicylsalicylic.acid, AM.404, tryptanthrin, FR.122047, piroxicam, naproxen",0.382999658879101,0.0301183562535,FALSE +"H1648","Pearson.est","cytochrome P450 inhibitor",0.50524,1.33,0.155,318,0.904,"PF.4981517, morin, eplerenone",0.809668301829709,0.0438315695246367,FALSE +"H1648","Pearson.est","DNA alkylating agent",-0.31305,-0.814,0.664,942,0.94,"TH.302, mitomycin.c, carmustine, streptozotocin, melphalan, satraplatin, cyclophosphamide, temozolomide",0.177831920631982,0.0268721464003014,FALSE +"H1648","Pearson.est","DNA inhibitor",-0.23659,-0.607,0.905,1363,0.935,"pibenzimol, nithiamide",0.0433514207947967,0.0291883891274822,FALSE +"H1648","Pearson.est","DNA methyltransferase inhibitor",0.60751,1.59,0.0615,564,0.536,"decitabine, SGI.1027, azacitidine, fdcyd, RG108",1.21112488422458,0.27083521030723,FALSE +"H1648","Pearson.est","DNA polymerase inhibitor",0.41069,1.07,0.386,238,0.919,"foscarnet, cephalomannine, cidofovir, idoxuridine",0.413412695328245,0.0366844886138887,FALSE +"H1648","Pearson.est","DNA synthesis inhibitor",-0.33966,-0.886,0.564,1388,0.957,"altretamine, enocitabine",0.248720896016658,0.0190880622231565,FALSE +"H1648","Pearson.est","dopamine receptor antagonist",-0.3466,-0.903,0.545,1190,0.956,"ziprasidone, paliperidone, remoxipride, lurasidone, amisulpride",0.263603497723358,0.0195421077238999,FALSE +"H1648","Pearson.est","estrogen receptor agonist",-0.2993,-0.779,0.708,1101,0.974,"ethinyl.estradiol, estrone, erteberel",0.149966742310231,0.0114410431213845,FALSE +"H1648","Pearson.est","estrogen receptor antagonist",-0.80953,-2.18,0,1265,0.0261,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.58335949266172,TRUE +"H1648","Pearson.est","FGFR inhibitor",-0.2427,-0.633,0.878,349,0.953,"orantinib, regorafenib, erdafitinib, AZD4547, PD.173074, dovitinib, nintedanib, MK.2461, lenvatinib, lucitanib",0.0565054840938974,0.0209070993616736,FALSE +"H1648","Pearson.est","FLT3 inhibitor",-0.3725,-1,0.433,1155,0.933,"pacritinib, TG.101348, quizartinib, KW.2449, TG.02, sunitinib, lestaurtinib",0.363512103646635,0.0301183562535,FALSE +"H1648","Pearson.est","glucocorticoid receptor agonist",-0.39656,-1.05,0.377,999,1,"halcinonide, desonide, triamcinolone.acetonide, flumethasone, rimexolone, triamcinolone, prednisolone, prednisolone.acetate, beclomethasone.dipropionate, fluticasone.propionate, piretanide, fluocinolone.acetonide, flumethasone.pivalate, dexamethasone.acetate, hydrocortisone",0.423658649794207,0,FALSE +"H1648","Pearson.est","glutamate receptor antagonist",0.28994,0.746,0.758,351,0.932,"ACDPP, tiletamine, kynurenic.acid, CGP.37849",0.120330794367946,0.0305840876460186,FALSE +"H1648","Pearson.est","glycogen synthase kinase inhibitor",0.36302,0.928,0.53,33,0.862,"CHIR.99021",0.275724130399211,0.0644927341752872,FALSE +"H1648","Pearson.est","growth factor receptor inhibitor",-0.56773,-1.48,0.0875,1012,0.484,"GSK1904529A, PHA.848125, GSK1838705A, GW.441756, lestaurtinib",1.05799194697769,0.315154638355588,FALSE +"H1648","Pearson.est","HCV inhibitor",0.41064,1.08,0.365,71,0.957,"daclatasvir",0.437707135543525,0.0190880622231565,FALSE +"H1648","Pearson.est","HDAC inhibitor",0.46699,1.2,0.266,341,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, ACY.1215, entinostat, M.344, resminostat, mocetinostat",0.575118363368933,0,FALSE +"H1648","Pearson.est","histamine receptor antagonist",-0.2381,-0.616,0.927,1003,0.948,"ICI.162846, cyproheptadine, ranitidine, tiotidine, terfenadine, ebastine, epinastine, BF2.649",0.0329202658555029,0.0231916626619338,FALSE +"H1648","Pearson.est","HMGCR inhibitor",0.40417,1.05,0.381,185,0.91,"atorvastatin, simvastatin",0.419075024324381,0.0409586076789064,FALSE +"H1648","Pearson.est","HSP inhibitor",0.52317,1.38,0.15,244,0.878,"BIIB021, NMS.E973, PU.H71, SNX.2112, NVP.AUY922, SNX.5422, ganetespib",0.823908740944319,0.0565054840938974,FALSE +"H1648","Pearson.est","JAK inhibitor",-0.377,-1,0.429,1155,0.933,"pacritinib, TG.101348, filgotinib, AZD1480, CEP.33779, TG.02, lestaurtinib",0.367542707815276,0.0301183562535,FALSE +"H1648","Pearson.est","KIT inhibitor",-0.2915,-0.765,0.746,1294,0.869,"vatalanib, telatinib, sunitinib, masitinib",0.127261172527331,0.0609802235513335,FALSE +"H1648","Pearson.est","MDM inhibitor",-0.29473,-0.778,0.718,425,0.947,"serdemetan, idasanutlin, AMG.232, CGM097, nutlin.3, RITA",0.1438755557577,0.0236500209967266,FALSE +"H1648","Pearson.est","MEK inhibitor",-0.32479,-0.858,0.617,1215,0.945,"refametinib, nobiletin, BIX.02188, MEK162, arctigenin",0.209714835966758,0.0245681914907371,FALSE +"H1648","Pearson.est","MET inhibitor",-0.63363,-1.66,0.0489,1157,0.327,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.31069114087638,0.485452247339714,FALSE +"H1648","Pearson.est","microtubule inhibitor",0.39871,1.02,0.419,158,0.828,"estramustine.phosphate, triclabendazole",0.377785977033705,0.0819696632151199,FALSE +"H1648","Pearson.est","mTOR inhibitor",0.68077,1.73,0.0155,311,0.977,"deforolimus, PI.103, AZD8055, PKI.179, everolimus, torin.1, temsirolimus, NVP.BEZ235, LY3023414, MLN0128, AZD2014, PP242, GDC.0980, sirolimus, torin.2, WYE.125132, SB.2343, voxtalisib, palomid.529",1.80966830182971,0.0101054362812269,FALSE +"H1648","Pearson.est","NFkB pathway inhibitor",-0.42286,-1.09,0.338,1016,1,"tyloxapol, IKK.2.inhibitor.V, curcumin, bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.471083299722345,0,FALSE +"H1648","Pearson.est","opioid receptor agonist",-0.42753,-1.13,0.296,1270,1,"ADL5859, salvinorin.a",0.528708288941061,0,FALSE +"H1648","Pearson.est","p38 MAPK inhibitor",-0.22903,-0.594,0.92,1089,0.924,"TAK.715, skepinone.l",0.0362121726544447,0.0343280287798933,FALSE +"H1648","Pearson.est","PARP inhibitor",-0.57872,-1.54,0.0747,1001,0.428,"AZD2461, niraparib, olaparib, AG.14361, talazoparib",1.1266793981846,0.368556230986828,FALSE +"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30889,-0.83,0.624,1294,0.971,"vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.204815410317576,0.0127807700919951,FALSE +"H1648","Pearson.est","phosphatase inhibitor",-0.33563,-0.862,0.596,1194,0.971,"menadione, CID.5458317, alexidine",0.224753740259764,0.0127807700919951,FALSE +"H1648","Pearson.est","phosphodiesterase inhibitor",0.28265,0.734,0.769,278,0.92,"papaverine, enoximone, EMD.53998",0.114073660198569,0.0362121726544447,FALSE +"H1648","Pearson.est","PI3K inhibitor",0.3714,0.947,0.511,360,0.861,"PI.103, PKI.179, BGT226, NVP.BEZ235, LY3023414, GDC.0980, SB.2343, voxtalisib, ZSTK.474, PF.04691502, buparlisib",0.291579099865287,0.0649968485463452,FALSE +"H1648","Pearson.est","PLK inhibitor",0.31783,0.833,0.669,990,0.847,"HMN.214, BI.2536, volasertib, NMS.1286937, GSK461364, rigosertib, GW.843682X",0.174573882232177,0.0721165896692931,FALSE +"H1648","Pearson.est","potassium channel blocker",0.61961,1.63,0.0454,390,0.588,"ML133, ibutilide, mepivacaine, oleoylethanolamide, dofetilide",1.3429441471429,0.230622673923862,FALSE +"H1648","Pearson.est","PPAR receptor agonist",-0.28311,-0.748,0.749,1387,0.851,"fenofibrate",0.125518182300534,0.0700704399154121,FALSE +"H1648","Pearson.est","progesterone receptor agonist",-0.71232,-1.85,0.0172,1214,0.15,"norgestrel, dienogest, danazol, melengestrol.acetate, nomegestrol.acetate, norethindrone.acetate",1.76447155309245,0.823908740944319,TRUE +"H1648","Pearson.est","proteasome inhibitor",0.34414,0.886,0.567,210,0.81,"ONX.0914, MG.132",0.246416941107093,0.0915149811213502,FALSE +"H1648","Pearson.est","protein synthesis inhibitor",0.26426,0.682,0.83,304,0.91,"clofoctol, cycloheximide, brefeldin.a, puromycin, thiostrepton",0.0809219076239261,0.0409586076789064,FALSE +"H1648","Pearson.est","protein tyrosine kinase inhibitor",-0.29945,-0.775,0.711,1338,0.926,"CP.724714, rheochrysidin",0.148130399270234,0.0333890133180656,FALSE +"H1648","Pearson.est","RAF inhibitor",0.45136,1.17,0.281,371,1,"SB.590885, vemurafenib, LGX818, sorafenib, dabrafenib, AZ.628",0.55129368009492,0,FALSE +"H1648","Pearson.est","RET tyrosine kinase inhibitor",-0.35813,-0.926,0.54,1397,0.978,"sunitinib",0.267606240177031,0.00966114521239857,FALSE +"H1648","Pearson.est","retinoid receptor agonist",0.30451,0.789,0.709,280,0.893,"LE.135, adarotene",0.149353764816933,0.0491485411114536,FALSE +"H1648","Pearson.est","ribonucleotide reductase inhibitor",-0.37293,-0.94,0.505,1441,0.987,"pentostatin",0.296708621881339,0.00568284733036327,FALSE +"H1648","Pearson.est","serotonin receptor agonist",-0.68253,-1.84,0.0247,1208,0.131,"NAN.190, ipsapirone, zolmitriptan, aripiprazole",1.60730304674033,0.882728704344236,TRUE +"H1648","Pearson.est","serotonin receptor antagonist",-0.42248,-1.08,0.347,1093,1,"RS.16566, tropisetron, ziprasidone, paliperidone, lurasidone, aripiprazole",0.459670525209126,0,FALSE +"H1648","Pearson.est","sodium channel blocker",0.37794,0.988,0.473,382,0.853,"brivaracetam, ajmaline, cibenzoline, mepivacaine, butamben, mexiletine",0.325138859262188,0.069050968832477,FALSE +"H1648","Pearson.est","src inhibitor",-0.35053,-0.909,0.542,1291,0.98,"PP.2, masitinib",0.266000713461613,0.00877392430750515,FALSE +"H1648","Pearson.est","sterol demethylase inhibitor",0.34072,0.9,0.571,14,0.847,"chlormidazole",0.243363891754152,0.0721165896692931,FALSE +"H1648","Pearson.est","TGF beta receptor inhibitor",-0.47678,-1.26,0.208,1002,0.846,"SB.431542, adaprev, SB.525334, D.4476",0.681936665037238,0.0726296369609765,FALSE +"H1648","Pearson.est","thymidylate synthase inhibitor",-0.2982,-0.767,0.736,430,0.889,"ftorafur, doxifluridine, raltitrexed, carmofur, capecitabine, trifluridine",0.133122185662501,0.0510982390297863,FALSE +"H1648","Pearson.est","topoisomerase inhibitor",0.2791,0.731,0.795,133,0.897,"mitoxantrone, idarubicin, exatecan.mesylate, doxorubicin",0.0996328713435297,0.0472075569559079,FALSE +"H1648","Pearson.est","tubulin polymerization inhibitor",0.4118,1.08,0.324,499,0.957,"mebendazole, epothilone.b, oxibendazole, BNC105, CYT.997, vinorelbine, fenbendazole, taltobulin, indibulin, verubulin, dolastatin.10, plinabulin, podophyllotoxin, KX2.391, parbendazole",0.489454989793388,0.0190880622231565,FALSE +"H1648","Pearson.est","tyrosine kinase inhibitor",0.24889,0.638,0.88,517,0.936,"dasatinib, AV.412, bafetinib, NVP.TAE226, mubritinib, sorafenib, GTP.14564, tyrphostin.A9, vandetanib, tivantinib, apatinib, PP.121, regorafenib",0.0555173278498314,0.0287241512618947,FALSE +"H1648","Pearson.est","VEGFR inhibitor",0.20014,0.516,0.963,135,0.973,"BMS.690514, XL.647, OSI.930, SAR131675",0.0163737128754655,0.0118871597316481,FALSE +"H1648","Pearson.est","vitamin D receptor agonist",0.56759,1.43,0.111,515,0.877,"ercalcitriol, calcitriol, maxacalcitol, tacalcitol, doxercalciferol",0.954677021213343,0.0570004066339595,FALSE +"H1975","Pearson.est","EGFR inhibitor",0.40808,1.07,0.356,381,1,"CUDC.101, ARRY.334543, BMS.690514, tyrphostin.AG.1478, erlotinib, WZ.3146, XL.647, canertinib, gefitinib, AST.1306, brigatinib, BIBU.1361, PD.168393, lapatinib, AZD8931, icotinib, BIBX.1382, afatinib, pelitinib, osimertinib",0.448550002027125,0,FALSE +"H1975","Pearson.est","Abl kinase inhibitor",0.28576,0.734,0.776,226,0.897,"dasatinib, metatinib, bafetinib",0.110138278741812,0.0472075569559079,FALSE +"H1975","Pearson.est","acetylcholine receptor agonist",-0.20219,-0.517,0.968,1300,0.972,"nicotine",0.0141246426916063,0.0123337350737254,FALSE +"H1975","Pearson.est","acetylcholine receptor antagonist",-0.79312,-2.11,0,1299,0.0305,"dicycloverine, methscopolamine, iododexetimide",Inf,1.51570016065321,TRUE +"H1975","Pearson.est","adenosine receptor antagonist",0.34054,0.88,0.579,153,0.89,"theophylline, PSB.1115",0.237321436272564,0.0506099933550872,FALSE +"H1975","Pearson.est","adrenergic receptor agonist",-0.37351,-0.985,0.454,1416,0.96,"norepinephrine, isoetharine",0.342944147142896,0.0177287669604316,FALSE +"H1975","Pearson.est","adrenergic receptor antagonist",0.32942,0.868,0.609,197,0.879,"practolol, idazoxan, propranolol, vincamine",0.215382707367125,0.0560111249262281,FALSE +"H1975","Pearson.est","AKT inhibitor",0.39086,1.02,0.401,475,0.996,"MK.2206, triciribine, ONC201, palomid.529, AT7867, GSK2110183",0.396855627379818,0.00174066157630127,FALSE +"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.36373,-0.977,0.464,1214,0.936,"alectinib, CEP.37440, DMH1",0.333482019445119,0.0287241512618947,FALSE +"H1975","Pearson.est","androgen receptor antagonist",-0.75071,-1.98,0.0102,1223,0.0779,"flutamide, nilutamide, enzalutamide, cyproterone.acetate",1.99139982823808,1.10846254232744,TRUE +"H1975","Pearson.est","antioxidant",-0.62945,-1.63,0.0487,1141,0.334,"benfotiamine, trolox",1.31247103878537,0.476253533188435,FALSE +"H1975","Pearson.est","AP inhibitor",0.64682,1.67,0.0383,55,0.677,"birinapant, GDC.0152",1.41680122603138,0.169411331314856,FALSE +"H1975","Pearson.est","ATPase inhibitor",0.37475,0.975,0.479,215,0.996,"k.strophanthidin, oligomycin.a, ouabain, evodiamine",0.319664486585437,0.00174066157630127,FALSE +"H1975","Pearson.est","Aurora kinase inhibitor",0.26124,0.668,0.858,518,0.93,"MK.5108, MK.8745, barasertib.HQPA, barasertib, ENMD.2076, alisertib, ZM.447439, PF.03814735, CCT137690, danusertib, MLN.8054",0.0665127121512946,0.0315170514460649,FALSE +"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.36785,-0.964,0.484,1331,0.85,"azalomycin.b, dirithromycin",0.315154638355588,0.0705810742857073,FALSE +"H1975","Pearson.est","bacterial DNA gyrase inhibitor",0.39227,1.01,0.411,343,0.962,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.386158178123931,0.0168249279621871,FALSE +"H1975","Pearson.est","BCL inhibitor",-0.39726,-1.04,0.38,1411,1,"gossypol, ABT.737",0.42021640338319,0,FALSE +"H1975","Pearson.est","Bcr.Abl kinase inhibitor",0.34819,0.903,0.538,226,0.883,"dasatinib, metatinib, bafetinib",0.269217724333611,0.0540392964224314,FALSE +"H1975","Pearson.est","benzodiazepine receptor agonist",0.45473,1.18,0.25,98,1,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.602059991327962,0,FALSE +"H1975","Pearson.est","bromodomain inhibitor",-0.38166,-1.01,0.433,1163,0.945,"I.BET151, PFI.1",0.363512103646635,0.0245681914907371,FALSE +"H1975","Pearson.est","calcium channel blocker",-0.34609,-0.899,0.547,1125,0.828,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.262012673666569,0.0819696632151199,FALSE +"H1975","Pearson.est","CC chemokine receptor antagonist",-0.21374,-0.565,0.949,308,0.989,"ZK811752, UNBS.5162, MK.0812, RS.504393, SB.225002, navarixin, PF.04136309",0.0227337875727074,0.0048037084028206,FALSE +"H1975","Pearson.est","CDK inhibitor",-0.22725,-0.583,0.932,985,0.998,"PHA.848125, AZD5438, R547, abemaciclib, indirubin, ribociclib, JNJ.7706621, TG.02, BMS.265246",0.0305840876460186,0.000869458712628891,FALSE +"H1975","Pearson.est","CHK inhibitor",-0.45719,-1.2,0.241,1143,1,"SCH.900776, AZD7762, SB.218078",0.617982957425132,0,FALSE +"H1975","Pearson.est","cyclooxygenase inhibitor",-0.43817,-1.14,0.283,1256,1,"AM.404, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam, naproxen",0.54821356447571,0,FALSE +"H1975","Pearson.est","cytochrome P450 inhibitor",0.50427,1.31,0.176,336,1,"PF.4981517, morin, eplerenone",0.75448733218585,0,FALSE +"H1975","Pearson.est","DNA alkylating agent",-0.35691,-0.941,0.487,1027,0.833,"TH.302, carmustine, melphalan, streptozotocin, satraplatin, cyclophosphamide, temozolomide",0.312471038785366,0.0793549985932124,FALSE +"H1975","Pearson.est","DNA inhibitor",-0.2777,-0.708,0.788,1379,0.904,"nithiamide, pibenzimol",0.103473782510445,0.0438315695246367,FALSE +"H1975","Pearson.est","DNA methyltransferase inhibitor",0.62577,1.63,0.0508,457,0.563,"azacitidine, SGI.1027, fdcyd, decitabine",1.29413628771608,0.249491605148654,FALSE +"H1975","Pearson.est","DNA polymerase inhibitor",0.3896,1.02,0.449,257,0.996,"foscarnet, cidofovir, cephalomannine, idoxuridine",0.347753658996677,0.00174066157630127,FALSE +"H1975","Pearson.est","DNA synthesis inhibitor",-0.28476,-0.736,0.751,1350,0.909,"altretamine, enocitabine",0.124360062995832,0.0414361167780325,FALSE +"H1975","Pearson.est","dopamine receptor antagonist",-0.33187,-0.868,0.588,1034,0.811,"nemonapride, mesoridazine, ziprasidone, remoxipride, paliperidone, lurasidone, amisulpride",0.230622673923862,0.090979145788844,FALSE +"H1975","Pearson.est","estrogen receptor agonist",-0.37017,-0.97,0.464,1137,0.911,"ethinyl.estradiol, estrone, erteberel",0.333482019445119,0.0404816230270017,FALSE +"H1975","Pearson.est","estrogen receptor antagonist",-0.81816,-2.14,0.00412,1286,0.0474,"danazol, raloxifene, fulvestrant, tamoxifen",2.38510278396687,1.32422165832591,TRUE +"H1975","Pearson.est","FGFR inhibitor",-0.29302,-0.774,0.731,1005,0.9,"MK.2461, nintedanib, lenvatinib, lucitanib",0.13608262304214,0.0457574905606751,FALSE +"H1975","Pearson.est","FLT3 inhibitor",-0.39948,-1.02,0.393,1178,0.969,"pacritinib, TG.101348, quizartinib, KW.2449, TG.02, sunitinib, lestaurtinib",0.405607449624573,0.0136762229492347,FALSE +"H1975","Pearson.est","glucocorticoid receptor agonist",-0.35434,-0.898,0.569,910,0.803,"fludroxycortide, desonide, clobetasol.propionate, triamcinolone.acetonide, halcinonide, flumethasone, triamcinolone, rimexolone, prednisolone, prednisolone.acetate, beclomethasone.dipropionate, fluticasone.propionate, fluocinolone.acetonide, piretanide, flumethasone.pivalate, dexamethasone.acetate, hydrocortisone",0.244887733604929,0.095284454721319,FALSE +"H1975","Pearson.est","glutamate receptor antagonist",0.3251,0.837,0.657,203,0.871,"ACDPP, tiletamine, kynurenic.acid",0.182434630440219,0.0599818449923368,FALSE +"H1975","Pearson.est","glycogen synthase kinase inhibitor",0.3954,1.04,0.421,33,1,"CHIR.99021",0.375717904164332,0,FALSE +"H1975","Pearson.est","growth factor receptor inhibitor",-0.58762,-1.55,0.0551,1224,0.417,"GSK1838705A, GW.441756, lestaurtinib",1.25884840114821,0.379863945026242,FALSE +"H1975","Pearson.est","HCV inhibitor",0.41189,1.06,0.407,54,1,"daclatasvir",0.39040559077478,0,FALSE +"H1975","Pearson.est","HDAC inhibitor",0.43857,1.15,0.299,445,1,"nexturastat.a, chidamide, panobinostat, belinostat, NSC.3852, scriptaid, SB.939, entinostat, ACY.1215, M.344, resminostat, romidepsin, mocetinostat, givinostat",0.52432881167557,0,FALSE +"H1975","Pearson.est","histamine receptor antagonist",-0.2434,-0.642,0.878,972,0.963,"lafutidine, ICI.162846, cyproheptadine, ranitidine, terfenadine, tiotidine, ebastine, BF2.649, epinastine",0.0565054840938974,0.0163737128754655,FALSE +"H1975","Pearson.est","HMGCR inhibitor",0.31035,0.816,0.664,267,0.88,"atorvastatin, simvastatin",0.177831920631982,0.0555173278498314,FALSE +"H1975","Pearson.est","HSP inhibitor",0.48947,1.28,0.19,258,1,"BIIB021, NMS.E973, PU.H71, SNX.2112, NVP.AUY922, SNX.5422, ganetespib",0.721246399047171,0,FALSE +"H1975","Pearson.est","JAK inhibitor",-0.39369,-1.02,0.395,1177,0.969,"CEP.33779, pacritinib, TG.101348, AZD1480, TG.02, filgotinib, lestaurtinib",0.40340290437354,0.0136762229492347,FALSE +"H1975","Pearson.est","KIT inhibitor",-0.28998,-0.737,0.746,1102,0.932,"imatinib, lenvatinib, KI.8751, telatinib, vatalanib, sunitinib, masitinib",0.127261172527331,0.0305840876460186,FALSE +"H1975","Pearson.est","MDM inhibitor",-0.2862,-0.729,0.75,1013,0.896,"nutlin.3, CGM097, RITA",0.1249387366083,0.0476919903378748,FALSE +"H1975","Pearson.est","MEK inhibitor",-0.30813,-0.802,0.688,1182,0.878,"refametinib, nobiletin, BIX.02188, MEK162, arctigenin",0.162411561764489,0.0565054840938974,FALSE +"H1975","Pearson.est","MET inhibitor",-0.63959,-1.66,0.0471,1153,0.331,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.3269790928711,0.480172006224281,FALSE +"H1975","Pearson.est","microtubule inhibitor",0.43555,1.11,0.32,149,1,"estramustine.phosphate, triclabendazole",0.494850021680094,0,FALSE +"H1975","Pearson.est","mTOR inhibitor",0.69201,1.81,0.021,187,0.563,"deforolimus, PI.103, AZD8055, PKI.179, torin.1, everolimus, temsirolimus, NVP.BEZ235, LY3023414, PP242, MLN0128, AZD2014, sirolimus, GDC.0980, torin.2, WYE.125132",1.67778070526608,0.249491605148654,FALSE +"H1975","Pearson.est","NFkB pathway inhibitor",-0.41013,-1.06,0.374,1221,1,"bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.42712839779952,0,FALSE +"H1975","Pearson.est","opioid receptor agonist",-0.45098,-1.15,0.301,1266,1,"ADL5859, salvinorin.a",0.521433504406157,0,FALSE +"H1975","Pearson.est","p38 MAPK inhibitor",-0.20305,-0.53,0.971,1298,0.987,"skepinone.l",0.0127807700919951,0.00568284733036327,FALSE +"H1975","Pearson.est","PARP inhibitor",-0.54853,-1.43,0.126,980,0.6,"olaparib, AZD2461, niraparib, AG.14361, talazoparib",0.899629454882437,0.221848749616356,FALSE +"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.36807,-0.939,0.504,1019,0.808,"crenolanib, ponatinib, nintedanib, imatinib, lenvatinib, KI.8751, axitinib, telatinib, vatalanib, CP.673451, sunitinib, masitinib",0.297569463554475,0.0925886392254138,FALSE +"H1975","Pearson.est","phosphatase inhibitor",-0.40778,-1.08,0.329,1241,1,"CID.5458317, menadione, alexidine",0.482804102050026,0,FALSE +"H1975","Pearson.est","phosphodiesterase inhibitor",0.24375,0.646,0.905,164,0.928,"papaverine, enoximone",0.0433514207947967,0.0324520237811379,FALSE +"H1975","Pearson.est","PI3K inhibitor",0.3678,0.936,0.542,476,0.934,"PI.103, PKI.179, BGT226, NVP.BEZ235, LY3023414, GDC.0980, voxtalisib, SB.2343, ZSTK.474, buparlisib, PF.04691502, PI3K.IN.2, PF.05212384, PI.828, CUDC.907",0.266000713461613,0.0296531237699066,FALSE +"H1975","Pearson.est","PLK inhibitor",0.34906,0.92,0.534,945,0.886,"HMN.214, BI.2536, volasertib, NMS.1286937, GSK461364, rigosertib, GW.843682X",0.272458742971444,0.0525662781129492,FALSE +"H1975","Pearson.est","potassium channel blocker",0.58388,1.51,0.0742,464,0.755,"ML133, ibutilide, dofetilide, oleoylethanolamide, mepivacaine",1.12959609472097,0.122053048370812,FALSE +"H1975","Pearson.est","PPAR receptor agonist",-0.34172,-0.873,0.571,1085,0.827,"S26948, clofibrate, fenofibrate",0.243363891754152,0.0824944904474534,FALSE +"H1975","Pearson.est","progesterone receptor agonist",-0.65785,-1.71,0.037,1170,0.306,"dienogest, norgestrel, melengestrol.acetate, danazol, nomegestrol.acetate, norethindrone.acetate",1.431798275933,0.51427857351842,FALSE +"H1975","Pearson.est","proteasome inhibitor",0.3742,0.971,0.464,198,0.954,"ONX.0914, MG.132",0.333482019445119,0.0204516252959049,FALSE +"H1975","Pearson.est","protein synthesis inhibitor",0.28551,0.738,0.772,400,0.918,"clofoctol, cycloheximide, brefeldin.a, thiostrepton, puromycin, methacycline, azomycin..2.nitroimidazole.",0.112382699664264,0.0371573187987575,FALSE +"H1975","Pearson.est","protein tyrosine kinase inhibitor",-0.31976,-0.831,0.671,1354,0.852,"CP.724714, rheochrysidin",0.173277479831008,0.0695604052332999,FALSE +"H1975","Pearson.est","RAF inhibitor",0.46132,1.18,0.283,339,1,"SB.590885, vemurafenib, sorafenib, LGX818, dabrafenib, AZ.628",0.54821356447571,0,FALSE +"H1975","Pearson.est","RET tyrosine kinase inhibitor",-0.3526,-0.923,0.533,1384,0.811,"sunitinib",0.273272790973428,0.090979145788844,FALSE +"H1975","Pearson.est","retinoid receptor agonist",0.31175,0.813,0.69,71,0.856,"LE.135",0.161150909262745,0.0675262353228468,FALSE +"H1975","Pearson.est","ribonucleotide reductase inhibitor",-0.36384,-0.951,0.491,1442,0.845,"pentostatin",0.308918507877032,0.0731432910503077,FALSE +"H1975","Pearson.est","serotonin receptor agonist",-0.67638,-1.75,0.0264,1327,0.306,"zolmitriptan, ipsapirone, aripiprazole",1.57839607313017,0.51427857351842,FALSE +"H1975","Pearson.est","serotonin receptor antagonist",-0.38782,-1.03,0.395,1283,1,"paliperidone, lurasidone, aripiprazole",0.40340290437354,0,FALSE +"H1975","Pearson.est","sodium channel blocker",0.33324,0.853,0.605,464,0.874,"brivaracetam, ajmaline, butamben, cibenzoline, mexiletine, mepivacaine",0.218244625347531,0.058488567365597,FALSE +"H1975","Pearson.est","src inhibitor",-0.36515,-0.965,0.481,1056,0.883,"bosutinib, PP.1, PP.2, masitinib",0.317854923626168,0.0540392964224314,FALSE +"H1975","Pearson.est","sterol demethylase inhibitor",0.36424,0.949,0.508,10,0.954,"chlormidazole",0.294136287716081,0.0204516252959049,FALSE +"H1975","Pearson.est","TGF beta receptor inhibitor",-0.52052,-1.39,0.141,969,0.62,"adaprev, repsox, SB.431542, D.4476, SB.525334",0.85078088734462,0.207608310501746,FALSE +"H1975","Pearson.est","thymidylate synthase inhibitor",0.31521,0.799,0.7,586,0.85,"ftorafur, raltitrexed, doxifluridine, carmofur",0.154901959985743,0.0705810742857073,FALSE +"H1975","Pearson.est","topoisomerase inhibitor",0.26911,0.701,0.812,171,0.916,"mitoxantrone, doxorubicin, idarubicin, exatecan.mesylate",0.0904439707588247,0.0381045263321496,FALSE +"H1975","Pearson.est","tubulin polymerization inhibitor",0.36538,0.931,0.534,530,0.903,"mebendazole, epothilone.b, oxibendazole, BNC105, vinorelbine, CYT.997, fenbendazole, taltobulin, indibulin, verubulin, dolastatin.10, plinabulin, podophyllotoxin, parbendazole, KX2.391",0.272458742971444,0.0443122496864942,FALSE +"H1975","Pearson.est","tyrosine kinase inhibitor",0.23559,0.598,0.935,437,0.948,"AV.412, dasatinib, NVP.TAE226, bafetinib, mubritinib, sorafenib, GTP.14564, apatinib, tyrphostin.A9, tivantinib",0.0291883891274822,0.0231916626619338,FALSE +"H1975","Pearson.est","VEGFR inhibitor",0.1975,0.514,0.975,125,0.974,"BMS.690514, OSI.930, XL.647, SAR131675",0.0109953843014632,0.0114410431213845,FALSE +"H1975","Pearson.est","vitamin D receptor agonist",0.5536,1.42,0.115,253,0.888,"ercalcitriol, calcitriol, maxacalcitol",0.939302159646388,0.051587034221399,FALSE +"HCC78","Pearson.est","EGFR inhibitor",0.341,0.884,0.568,321,0.943,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, erlotinib, WZ.3146, BMS.690514, XL.647, canertinib, gefitinib, AST.1306, BIBX.1382, brigatinib, PD.168393, icotinib, afatinib, BIBU.1361",0.245651664288981,0.0254883072626717,FALSE +"HCC78","Pearson.est","Abl kinase inhibitor",-0.3141,-0.797,0.671,1062,0.866,"bosutinib, ponatinib, imatinib, KW.2449, flumatinib",0.173277479831008,0.0624821079826534,FALSE +"HCC78","Pearson.est","acetylcholine receptor agonist",0.22299,0.571,0.942,356,1,"xanomeline, oxiracetam",0.0259490972071227,0,FALSE +"HCC78","Pearson.est","acetylcholine receptor antagonist",-0.73108,-1.88,0.0125,1075,0.145,"darifenacin, hyoscyamine, dicycloverine, methscopolamine, iododexetimide",1.90308998699194,0.838631997765025,TRUE +"HCC78","Pearson.est","adenosine receptor antagonist",-0.38965,-1,0.44,1199,0.788,"sulmazole, istradefylline",0.356547323513813,0.103473782510445,FALSE +"HCC78","Pearson.est","adrenergic receptor agonist",-0.4071,-1.03,0.423,858,0.758,"isoxsuprine, clenbuterol, midodrine, A61603, terbutaline, xylazine, ritodrine, oxymetazoline, methyldopa, norepinephrine, isoetharine",0.373659632624958,0.120330794367946,FALSE +"HCC78","Pearson.est","adrenergic receptor antagonist",0.34413,0.894,0.54,193,1,"practolol, propranolol, idazoxan, vincamine",0.267606240177031,0,FALSE +"HCC78","Pearson.est","AKT inhibitor",0.38476,1,0.448,421,1,"ONC201, MK.2206, triciribine, palomid.529, AT7867, GSK2110183",0.348721986001856,0,FALSE +"HCC78","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.45139,-1.16,0.293,1254,0.709,"alectinib, DMH1, CEP.37440",0.533132379645891,0.149353764816933,FALSE +"HCC78","Pearson.est","androgen receptor antagonist",-0.6846,-1.76,0.0239,1017,0.215,"nilutamide, bicalutamide, flutamide, enzalutamide, cyproterone.acetate",1.62160209905186,0.667561540084395,TRUE +"HCC78","Pearson.est","antioxidant",-0.45091,-1.16,0.288,784,0.709,"taurine, mesna, rutin, benfotiamine, trolox",0.540607512240769,0.149353764816933,FALSE +"HCC78","Pearson.est","AP inhibitor",0.65078,1.69,0.0364,75,0.633,"birinapant, GDC.0152",1.43889861635094,0.198596289982645,FALSE +"HCC78","Pearson.est","ATPase inhibitor",0.47025,1.23,0.23,264,1,"k.strophanthidin, oligomycin.a, ouabain, evodiamine, blebbistatin....",0.638272163982407,0,FALSE +"HCC78","Pearson.est","Aurora kinase inhibitor",0.23853,0.626,0.894,517,0.987,"MK.5108, MK.8745, barasertib.HQPA, barasertib, MLN.8054, alisertib, ENMD.2076, PF.03814735, CCT137690, ZM.447439, danusertib",0.0486624812040823,0.00568284733036327,FALSE +"HCC78","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.48588,-1.25,0.212,1359,0.774,"azalomycin.b, dirithromycin",0.673664139071249,0.111259039317107,FALSE +"HCC78","Pearson.est","bacterial DNA gyrase inhibitor",0.31691,0.846,0.64,418,0.931,"lomefloxacin, finafloxacin, novobiocin, trovafloxacin",0.193820026016113,0.0310503190186574,FALSE +"HCC78","Pearson.est","BCL inhibitor",-0.38284,-0.963,0.5,1408,0.805,"gossypol, ABT.737",0.301029995663981,0.0942041196321315,FALSE +"HCC78","Pearson.est","Bcr.Abl kinase inhibitor",-0.25988,-0.673,0.856,1062,0.919,"bosutinib, ponatinib, imatinib, flumatinib",0.0675262353228468,0.0366844886138887,FALSE +"HCC78","Pearson.est","benzodiazepine receptor agonist",0.39574,1.05,0.387,147,1,"ivermectin, gamma.aminobutyric.acid, bentazepam, ZK.93423",0.412289034981089,0,FALSE +"HCC78","Pearson.est","bromodomain inhibitor",-0.58823,-1.5,0.0734,1031,0.479,"JQ1...., bromosporine, I.BET151, PFI.1",1.13430394008393,0.319664486585437,FALSE +"HCC78","Pearson.est","calcium channel blocker",-0.41531,-1.06,0.385,1278,0.786,"SR.33805, efonidipine.monoethanolate, mibefradil",0.414539270491499,0.104577453960592,FALSE +"HCC78","Pearson.est","CC chemokine receptor antagonist",-0.23916,-0.61,0.902,965,0.948,"SB.225002, navarixin, PF.04136309",0.0447934624580583,0.0231916626619338,FALSE +"HCC78","Pearson.est","CDK inhibitor",-0.35257,-0.893,0.565,970,0.835,"palbociclib, PHA.848125, R547, AZD5438, indirubin, abemaciclib, ribociclib, BMS.265246, JNJ.7706621, TG.02",0.247951552180562,0.0783135245163979,FALSE +"HCC78","Pearson.est","CHK inhibitor",-0.53752,-1.43,0.103,1120,0.568,"SCH.900776, AZD7762, SB.218078",0.987162775294828,0.245651664288981,FALSE +"HCC78","Pearson.est","cyclooxygenase inhibitor",-0.35196,-0.919,0.519,976,0.837,"indoprofen, amfenac, curcumin, phenazone, AM.404, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam, naproxen",0.284832642151542,0.07727454200674,FALSE +"HCC78","Pearson.est","cytochrome P450 inhibitor",0.37844,0.997,0.459,398,0.963,"PF.4981517, morin, eplerenone",0.338187314462739,0.0163737128754655,FALSE +"HCC78","Pearson.est","DNA alkylating agent",-0.38433,-0.989,0.473,1050,0.781,"melphalan, TH.302, satraplatin, carmustine, streptozotocin, cyclophosphamide, temozolomide",0.325138859262188,0.1073489661227,FALSE +"HCC78","Pearson.est","DNA inhibitor",-0.21682,-0.546,0.944,1366,0.977,"nithiamide, pibenzimol",0.025028005701931,0.0101054362812269,FALSE +"HCC78","Pearson.est","DNA methyltransferase inhibitor",0.58329,1.55,0.0787,543,0.815,"azacitidine, fdcyd, SGI.1027, decitabine",1.10402526764094,0.0888423912600234,FALSE +"HCC78","Pearson.est","DNA polymerase inhibitor",0.31726,0.844,0.622,182,0.894,"foscarnet, cidofovir, cephalomannine",0.206209615309181,0.0486624812040823,FALSE +"HCC78","Pearson.est","DNA synthesis inhibitor",-0.32156,-0.82,0.629,1362,0.872,"altretamine, enocitabine",0.201349354554731,0.0594835150674328,FALSE +"HCC78","Pearson.est","dopamine receptor antagonist",-0.40342,-1.04,0.394,1196,0.796,"mesoridazine, remoxipride, ziprasidone, paliperidone, lurasidone, amisulpride",0.404503778174426,0.0990869322623309,FALSE +"HCC78","Pearson.est","estrogen receptor agonist",-0.3295,-0.852,0.622,1224,0.861,"estrone, erteberel",0.206209615309181,0.0649968485463452,FALSE +"HCC78","Pearson.est","estrogen receptor antagonist",-0.7845,-2.05,0.00186,1228,0.0497,"raloxifene, danazol, fulvestrant, tamoxifen",2.73048705578208,1.30364361126667,TRUE +"HCC78","Pearson.est","FGFR inhibitor",-0.46186,-1.19,0.28,1083,0.764,"lenvatinib, MK.2461, nintedanib, lucitanib",0.552841968657781,0.11690664142431,FALSE +"HCC78","Pearson.est","FLT3 inhibitor",-0.42337,-1.07,0.381,1097,0.797,"ponatinib, TG.101348, quizartinib, pacritinib, KW.2449, TG.02, sunitinib, lestaurtinib",0.419075024324381,0.0985416786038876,FALSE +"HCC78","Pearson.est","glucocorticoid receptor agonist",-0.29868,-0.772,0.732,1027,0.885,"rimexolone, flumethasone, prednisolone, prednisolone.acetate, hydrocortisone, beclomethasone.dipropionate, fluticasone.propionate, piretanide, fluocinolone.acetonide, dexamethasone.acetate, flumethasone.pivalate",0.135488918941608,0.0530567293021746,FALSE +"HCC78","Pearson.est","glutamate receptor antagonist",0.27773,0.731,0.779,225,0.915,"ACDPP, tiletamine, kynurenic.acid",0.108462542327436,0.0385789059335517,FALSE +"HCC78","Pearson.est","glycogen synthase kinase inhibitor",0.30364,0.794,0.678,80,0.876,"CHIR.99021",0.168770306132937,0.0574958938319193,FALSE +"HCC78","Pearson.est","growth factor receptor inhibitor",-0.60759,-1.56,0.0857,954,0.411,"AZD3463, PHA.848125, GSK1904529A, GW.441756, GSK1838705A, lestaurtinib",1.0670191780768,0.386158178123931,FALSE +"HCC78","Pearson.est","HCV inhibitor",0.40292,1.05,0.381,91,1,"daclatasvir",0.419075024324381,0,FALSE +"HCC78","Pearson.est","HDAC inhibitor",0.45832,1.22,0.226,256,1,"chidamide, nexturastat.a, panobinostat, NSC.3852, belinostat, scriptaid, ACY.1215, SB.939, entinostat, mocetinostat",0.645891560852599,0,FALSE +"HCC78","Pearson.est","histamine receptor antagonist",-0.25853,-0.676,0.835,1230,0.936,"epinastine, tiotidine, ebastine, BF2.649",0.0783135245163979,0.0287241512618947,FALSE +"HCC78","Pearson.est","HMGCR inhibitor",0.39262,1.04,0.383,222,1,"atorvastatin, simvastatin",0.416801226031377,0,FALSE +"HCC78","Pearson.est","HSP inhibitor",0.44375,1.16,0.257,334,1,"BIIB021, PU.H71, NMS.E973, NVP.AUY922, ganetespib, KW.2478, SNX.2112, SNX.5422",0.590066876668705,0,FALSE +"HCC78","Pearson.est","JAK inhibitor",-0.39908,-1.03,0.405,1105,0.758,"TG.101348, CEP.33779, filgotinib, pacritinib, AZD1480, TG.02, lestaurtinib",0.392544976785331,0.120330794367946,FALSE +"HCC78","Pearson.est","KIT inhibitor",-0.3613,-0.947,0.522,1083,0.811,"lenvatinib, imatinib, KI.8751, telatinib, vatalanib, sunitinib, masitinib",0.282329496997738,0.090979145788844,FALSE +"HCC78","Pearson.est","MDM inhibitor",0.31969,0.826,0.656,987,0.891,"serdemetan, idasanutlin, AMG.232, CGM097, nutlin.3, RITA",0.18309616062434,0.0501222959631252,FALSE +"HCC78","Pearson.est","MEK inhibitor",-0.29832,-0.771,0.745,1175,0.865,"refametinib, MEK162, BIX.02188, nobiletin, arctigenin",0.127843727251707,0.0629838925351858,FALSE +"HCC78","Pearson.est","MET inhibitor",-0.79985,-2.06,0,1287,0.0973,"INC.280, PHA.665752, NVP.BVU972, AMG458",Inf,1.01188715973165,TRUE +"HCC78","Pearson.est","microtubule inhibitor",0.38032,1,0.423,163,1,"estramustine.phosphate, triclabendazole",0.373659632624958,0,FALSE +"HCC78","Pearson.est","mTOR inhibitor",0.67089,1.77,0.0277,207,0.795,"deforolimus, PI.103, torin.1, AZD8055, PKI.179, NVP.BEZ235, PP242, LY3023414, everolimus, MLN0128, temsirolimus, AZD2014, sirolimus, SB.2343, GDC.0980, WYE.125132",1.55752023093555,0.0996328713435297,FALSE +"HCC78","Pearson.est","NFkB pathway inhibitor",-0.46883,-1.21,0.236,1044,0.761,"IKK.2.inhibitor.V, bortezomib, curcumin, bindarit, parthenolide, Ro.106.9920, betulinic.acid",0.627087997029893,0.118615343229427,FALSE +"HCC78","Pearson.est","opioid receptor agonist",-0.42735,-1.1,0.348,1203,0.805,"ADL5859, salvinorin.a",0.458420756053419,0.0942041196321315,FALSE +"HCC78","Pearson.est","p38 MAPK inhibitor",-0.30785,-0.799,0.696,1320,0.885,"skepinone.l",0.157390760389438,0.0530567293021746,FALSE +"HCC78","Pearson.est","PARP inhibitor",-0.59525,-1.56,0.0624,947,0.411,"PJ.34, niraparib, olaparib, AZD2461, AG.14361, talazoparib",1.20481541031758,0.386158178123931,FALSE +"HCC78","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.45176,-1.16,0.282,1083,0.709,"lenvatinib, ponatinib, imatinib, axitinib, nintedanib, KI.8751, telatinib, vatalanib, CP.673451, sunitinib, masitinib",0.549750891680639,0.149353764816933,FALSE +"HCC78","Pearson.est","phosphatase inhibitor",-0.3398,-0.864,0.603,1177,0.864,"CID.5458317, menadione, alexidine",0.219682687859849,0.0634862575211067,FALSE +"HCC78","Pearson.est","phosphodiesterase inhibitor",-0.20975,-0.542,0.973,1154,0.96,"trequinsin, GSK256066, avanafil",0.0118871597316481,0.0177287669604316,FALSE +"HCC78","Pearson.est","PI3K inhibitor",0.35322,0.926,0.527,169,1,"PI.103, PKI.179, NVP.BEZ235, LY3023414, BGT226, SB.2343, GDC.0980",0.278189384787453,0,FALSE +"HCC78","Pearson.est","PLK inhibitor",-0.32105,-0.825,0.636,847,0.886,"rigosertib, volasertib, GSK461364, NMS.1286937, GW.843682X",0.196542884351586,0.0525662781129492,FALSE +"HCC78","Pearson.est","potassium channel blocker",0.56481,1.51,0.096,408,0.725,"ibutilide, ML133, oleoylethanolamide, dofetilide",1.01772876696043,0.139661993429006,FALSE +"HCC78","Pearson.est","PPAR receptor agonist",-0.25675,-0.662,0.866,1364,0.913,"fenofibrate",0.0624821079826534,0.039529222465701,FALSE +"HCC78","Pearson.est","progesterone receptor agonist",-0.49519,-1.28,0.189,1130,0.76,"dienogest, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",0.723538195826756,0.119186407719209,FALSE +"HCC78","Pearson.est","proteasome inhibitor",0.35436,0.937,0.5,179,1,"ONX.0914, MG.132",0.301029995663981,0,FALSE +"HCC78","Pearson.est","protein synthesis inhibitor",0.33061,0.864,0.6,358,0.936,"clofoctol, cycloheximide, chloramphenicol.palmitate, brefeldin.a, azomycin..2.nitroimidazole., methacycline, thiostrepton",0.221848749616356,0.0287241512618947,FALSE +"HCC78","Pearson.est","protein tyrosine kinase inhibitor",-0.41083,-1.07,0.377,1282,0.797,"BMS.599626, CP.724714, rheochrysidin",0.423658649794207,0.0985416786038876,FALSE +"HCC78","Pearson.est","RAF inhibitor",0.24771,0.641,0.909,148,1,"SB.590885, vemurafenib",0.0414361167780325,0,FALSE +"HCC78","Pearson.est","RET tyrosine kinase inhibitor",-0.50005,-1.28,0.202,1401,0.76,"sunitinib",0.694648630553376,0.119186407719209,FALSE +"HCC78","Pearson.est","retinoid receptor agonist",0.30978,0.815,0.628,50,0.876,"LE.135",0.202040356262804,0.0574958938319193,FALSE +"HCC78","Pearson.est","ribonucleotide reductase inhibitor",-0.35043,-0.894,0.551,1438,0.858,"pentostatin",0.258848401148215,0.0665127121512946,FALSE +"HCC78","Pearson.est","serotonin receptor agonist",-0.69102,-1.79,0.0179,1338,0.216,"zolmitriptan, ipsapirone, aripiprazole",1.74714696902011,0.665546248849069,TRUE +"HCC78","Pearson.est","serotonin receptor antagonist",-0.4855,-1.23,0.231,1210,0.766,"ziprasidone, RS.16566, paliperidone, lurasidone, aripiprazole",0.636388020107856,0.115771230367396,FALSE +"HCC78","Pearson.est","sodium channel blocker",0.20848,0.545,0.968,446,0.989,"brivaracetam, cibenzoline, ajmaline, mexiletine, butamben",0.0141246426916063,0.0048037084028206,FALSE +"HCC78","Pearson.est","src inhibitor",-0.50457,-1.29,0.199,1062,0.864,"bosutinib, TG.100572, PP.1, PP.2, masitinib",0.701146923590293,0.0634862575211067,FALSE +"HCC78","Pearson.est","sterol demethylase inhibitor",0.34269,0.888,0.571,19,0.983,"chlormidazole",0.243363891754152,0.00744648216786438,FALSE +"HCC78","Pearson.est","TGF beta receptor inhibitor",-0.63175,-1.61,0.0584,1021,0.433,"SB.525334, repsox, SB.431542, adaprev, D.4476",1.2335871528876,0.363512103646635,FALSE +"HCC78","Pearson.est","thymidylate synthase inhibitor",0.20735,0.544,0.955,1149,0.959,"ftorafur, raltitrexed, doxifluridine, carmofur, capecitabine, trifluridine",0.0199966284162537,0.0181813928293364,FALSE +"HCC78","Pearson.est","topoisomerase inhibitor",0.27905,0.742,0.77,239,0.931,"doxorubicin, mitoxantrone, idarubicin, amsacrine, epirubicin, exatecan.mesylate",0.113509274827518,0.0310503190186574,FALSE +"HCC78","Pearson.est","tubulin polymerization inhibitor",0.38816,1.02,0.411,283,1,"mebendazole, BNC105, vinorelbine, epothilone.b, CYT.997, oxibendazole, verubulin, indibulin, fenbendazole, taltobulin",0.386158178123931,0,FALSE +"HCC78","Pearson.est","tyrosine kinase inhibitor",-0.27498,-0.71,0.789,1282,0.913,"BMS.599626, CP.724714, rheochrysidin, sunitinib",0.10292299679058,0.039529222465701,FALSE +"HCC78","Pearson.est","VEGFR inhibitor",-0.27872,-0.716,0.805,1083,0.926,"lenvatinib, axitinib, MK.2461, nintedanib, TG.100572, tivozanib, KI.8751, telatinib, lucitanib, vatalanib, foretinib, sunitinib",0.0942041196321315,0.0333890133180656,FALSE +"HCC78","Pearson.est","vitamin D receptor agonist",0.42489,1.12,0.312,379,1,"ercalcitriol, calcitriol, maxacalcitol",0.505845405981557,0,FALSE +"H2126","Pearson.est","EGFR inhibitor",0.46772,1.18,0.275,400,1,"CUDC.101, ARRY.334543, BMS.690514, tyrphostin.AG.1478, erlotinib, XL.647, canertinib, brigatinib, WZ.3146, gefitinib, BIBU.1361, AST.1306, PD.168393, icotinib, BIBX.1382, afatinib, rociletinib, pelitinib, AZD8931, lapatinib, osimertinib, vandetanib",0.560667306169737,0,FALSE +"H2126","Pearson.est","Abl kinase inhibitor",0.39366,1,0.441,171,0.889,"dasatinib, metatinib, bafetinib",0.355561410532161,0.0510982390297863,FALSE +"H2126","Pearson.est","acetylcholine receptor agonist",0.28109,0.702,0.821,474,0.899,"xanomeline, oxiracetam, tremorine",0.0856568428805592,0.0462403082667712,FALSE +"H2126","Pearson.est","acetylcholine receptor antagonist",-0.73604,-1.92,0.00952,1282,0.133,"dicycloverine, methscopolamine, iododexetimide",2.02136305161553,0.876148359032914,TRUE +"H2126","Pearson.est","adenosine receptor antagonist",-0.3705,-0.973,0.477,1432,0.9,"istradefylline",0.321481620959886,0.0457574905606751,FALSE +"H2126","Pearson.est","adrenergic receptor agonist",-0.39197,-1.02,0.412,1256,0.882,"ritodrine, methyldopa, norepinephrine, isoetharine",0.385102783966865,0.0545314148681803,FALSE +"H2126","Pearson.est","adrenergic receptor antagonist",0.35561,0.902,0.564,194,0.798,"practolol, idazoxan, propranolol, vincamine",0.248720896016658,0.0979971086492706,FALSE +"H2126","Pearson.est","AKT inhibitor",0.45184,1.17,0.296,402,1,"triciribine, MK.2206, palomid.529, AT7867, ONC201",0.528708288941061,0,FALSE +"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.21619,-0.579,0.925,1176,0.987,"alectinib, CEP.37440, DMH1",0.0338582672609674,0.00568284733036327,FALSE +"H2126","Pearson.est","androgen receptor antagonist",-0.72463,-1.88,0.00457,1177,0.131,"flutamide, nilutamide, enzalutamide, cyproterone.acetate",2.34008379993015,0.882728704344236,TRUE +"H2126","Pearson.est","antioxidant",-0.60913,-1.69,0.0483,1109,0.263,"benfotiamine, trolox",1.31605286924849,0.580044251510242,FALSE +"H2126","Pearson.est","AP inhibitor",0.62122,1.55,0.0651,75,0.696,"birinapant, GDC.0152",1.18641901143181,0.157390760389438,FALSE +"H2126","Pearson.est","ATPase inhibitor",0.4408,1.13,0.316,420,1,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873, thonzonium",0.500312917381596,0,FALSE +"H2126","Pearson.est","Aurora kinase inhibitor",0.40132,1.03,0.407,440,0.905,"MK.5108, barasertib, alisertib, barasertib.HQPA, MK.8745, ENMD.2076, ZM.447439, CCT137690, PF.03814735, danusertib, SNS.314",0.39040559077478,0.0433514207947967,FALSE +"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.28198,0.722,0.793,188,0.919,"tedizolid, azithromycin",0.100726812682396,0.0366844886138887,FALSE +"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.41172,1.04,0.376,343,0.928,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.424812155072339,0.0324520237811379,FALSE +"H2126","Pearson.est","BCL inhibitor",0.37377,0.972,0.478,327,0.838,"oridonin, TW.37, obatoclax, HA14.1, venetoclax",0.320572103387881,0.0767559813697235,FALSE +"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.43545,1.1,0.343,171,0.936,"dasatinib, metatinib, bafetinib",0.464705879957229,0.0287241512618947,FALSE +"H2126","Pearson.est","benzodiazepine receptor agonist",0.43451,1.09,0.334,104,0.907,"gamma.aminobutyric.acid, ZK.93423, ivermectin, bentazepam",0.476253533188435,0.0423927129399047,FALSE +"H2126","Pearson.est","bromodomain inhibitor",-0.38667,-1.02,0.396,1157,0.882,"I.BET151, PFI.1",0.402304814074488,0.0545314148681803,FALSE +"H2126","Pearson.est","calcium channel blocker",-0.31465,-0.834,0.643,1212,0.958,"efonidipine.monoethanolate, SR.33805, mibefradil",0.191789027075778,0.0186344909214556,FALSE +"H2126","Pearson.est","CC chemokine receptor antagonist",0.29142,0.74,0.766,464,0.916,"UNBS.5162, ZK811752, MK.0812, RS.504393",0.115771230367396,0.0381045263321496,FALSE +"H2126","Pearson.est","CDK inhibitor",-0.17111,-0.453,0.993,244,0.991,"alvocidib, kenpaullone, NU6027, CR8..R., P276.00, AT.7519, aminopurvalanol.a, dinaciclib, BMS.387032, indisulam, PHA.793887, palbociclib, PHA.848125, AZD5438, arcyriaflavin.a, R547, abemaciclib, indirubin, ribociclib, JNJ.7706621, BMS.265246, TG.02",0.00305075150461883,0.00392634551472468,FALSE +"H2126","Pearson.est","CHK inhibitor",-0.50799,-1.35,0.151,1179,0.674,"SCH.900776, AZD7762, SB.218078",0.821023052706831,0.17134010346468,FALSE +"H2126","Pearson.est","cyclooxygenase inhibitor",-0.42754,-1.15,0.309,1257,0.918,"acetylsalicylsalicylic.acid, piroxicam, FR.122047, AM.404, tryptanthrin, naproxen",0.510041520575165,0.0371573187987575,FALSE +"H2126","Pearson.est","cytochrome P450 inhibitor",0.56089,1.43,0.119,205,0.805,"PF.4981517, morin, eplerenone",0.924453038607469,0.0942041196321315,FALSE +"H2126","Pearson.est","DNA alkylating agent",-0.27459,-0.719,0.814,984,0.965,"mitomycin.c, carmustine, streptozotocin, melphalan, satraplatin, cyclophosphamide, temozolomide",0.0893755951107988,0.0154726866562074,FALSE +"H2126","Pearson.est","DNA inhibitor",-0.23948,-0.618,0.879,1361,1,"pibenzimol, nithiamide",0.0560111249262281,0,FALSE +"H2126","Pearson.est","DNA methyltransferase inhibitor",0.64372,1.65,0.0355,412,0.79,"SGI.1027, decitabine, azacitidine, fdcyd",1.44977164694491,0.102372908709559,FALSE +"H2126","Pearson.est","DNA polymerase inhibitor",0.42296,1.1,0.329,243,0.936,"foscarnet, cephalomannine, idoxuridine, cidofovir",0.482804102050026,0.0287241512618947,FALSE +"H2126","Pearson.est","DNA synthesis inhibitor",-0.33039,-0.882,0.574,1384,0.934,"altretamine, enocitabine",0.241088107602027,0.0296531237699066,FALSE +"H2126","Pearson.est","dopamine receptor antagonist",-0.38029,-0.979,0.467,1100,0.932,"mesoridazine, nemonapride, ziprasidone, paliperidone, remoxipride, amisulpride, lurasidone",0.330683119433888,0.0305840876460186,FALSE +"H2126","Pearson.est","estrogen receptor agonist",-0.3096,-0.814,0.656,1089,0.928,"ethinyl.estradiol, estrone, erteberel",0.18309616062434,0.0324520237811379,FALSE +"H2126","Pearson.est","estrogen receptor antagonist",-0.7989,-2.08,0.00228,1288,0.105,"danazol, raloxifene, fulvestrant, tamoxifen",2.64206515299955,0.978810700930062,TRUE +"H2126","Pearson.est","FGFR inhibitor",-0.25869,-0.67,0.862,372,1,"orantinib, AZD4547, regorafenib, erdafitinib, PD.173074, dovitinib, nintedanib, MK.2461, lucitanib, lenvatinib",0.0644927341752872,0,FALSE +"H2126","Pearson.est","FLT3 inhibitor",-0.30279,-0.815,0.64,1114,0.96,"KW.2449, pacritinib, TG.101348, quizartinib, TG.02, sunitinib, lestaurtinib",0.193820026016113,0.0177287669604316,FALSE +"H2126","Pearson.est","glucocorticoid receptor agonist",-0.37715,-1.02,0.412,971,0.882,"flumethasone, fludroxycortide, halcinonide, triamcinolone.acetonide, prednisolone, rimexolone, desonide, triamcinolone, beclomethasone.dipropionate, prednisolone.acetate, fluticasone.propionate, fluocinolone.acetonide, piretanide, dexamethasone.acetate, flumethasone.pivalate, hydrocortisone",0.385102783966865,0.0545314148681803,FALSE +"H2126","Pearson.est","glutamate receptor antagonist",0.39358,0.991,0.458,189,0.87,"ACDPP, kynurenic.acid, tiletamine",0.339134521996131,0.0604807473813815,FALSE +"H2126","Pearson.est","glycogen synthase kinase inhibitor",0.36233,0.918,0.543,29,0.853,"CHIR.99021",0.265200170411153,0.069050968832477,FALSE +"H2126","Pearson.est","growth factor receptor inhibitor",-0.55766,-1.46,0.111,1359,0.522,"GW.441756, lestaurtinib",0.954677021213343,0.282329496997738,FALSE +"H2126","Pearson.est","HCV inhibitor",0.3693,0.933,0.538,49,0.886,"daclatasvir",0.269217724333611,0.0525662781129492,FALSE +"H2126","Pearson.est","HDAC inhibitor",0.45539,1.16,0.267,308,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, M.344, ACY.1215, entinostat, resminostat",0.573488738635425,0,FALSE +"H2126","Pearson.est","histamine receptor antagonist",-0.24492,-0.636,0.872,1130,1,"terfenadine, tiotidine, ebastine, ranitidine, BF2.649, epinastine",0.0594835150674328,0,FALSE +"H2126","Pearson.est","HMGCR inhibitor",0.35417,0.915,0.548,224,0.829,"atorvastatin, simvastatin",0.261219441515631,0.0814454694497265,FALSE +"H2126","Pearson.est","HSP inhibitor",0.57332,1.43,0.112,203,0.805,"BIIB021, NMS.E973, PU.H71, SNX.5422, SNX.2112, NVP.AUY922, ganetespib",0.950781977329818,0.0942041196321315,FALSE +"H2126","Pearson.est","JAK inhibitor",-0.31846,-0.835,0.642,1141,0.994,"pacritinib, TG.101348, filgotinib, CEP.33779, AZD1480, TG.02, lestaurtinib",0.192464971931147,0.00261361560268669,FALSE +"H2126","Pearson.est","KIT inhibitor",0.31706,0.81,0.701,73,0.854,"midostaurin, OSI.930, dasatinib",0.154281982033341,0.068542129310995,FALSE +"H2126","Pearson.est","MDM inhibitor",-0.2337,-0.607,0.9,337,0.991,"serdemetan, idasanutlin, AMG.232, nutlin.3, CGM097, RITA",0.0457574905606751,0.00392634551472468,FALSE +"H2126","Pearson.est","MEK inhibitor",-0.2221,-0.576,0.932,1154,0.963,"refametinib, nobiletin, MEK162, BIX.02188, arctigenin",0.0305840876460186,0.0163737128754655,FALSE +"H2126","Pearson.est","MET inhibitor",-0.57195,-1.5,0.0876,1108,0.514,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.05749589383192,0.289036881004724,FALSE +"H2126","Pearson.est","microtubule inhibitor",0.35119,0.906,0.531,560,0.817,"estramustine.phosphate, triclabendazole, podophyllotoxin, cabazitaxel, D.64131",0.274905478918531,0.0877779434675845,FALSE +"H2126","Pearson.est","mTOR inhibitor",0.67791,1.75,0.0125,389,0.856,"deforolimus, PI.103, AZD8055, everolimus, PKI.179, NVP.BEZ235, temsirolimus, torin.1, MLN0128, AZD2014, LY3023414, PP242, torin.2, GDC.0980, WYE.125132, sirolimus, SB.2343, PF.04691502, palomid.529, ku.0063794, voxtalisib",1.90308998699194,0.0675262353228468,FALSE +"H2126","Pearson.est","NFkB pathway inhibitor",-0.3568,-0.917,0.545,1151,0.899,"tyloxapol, Ro.106.9920, bindarit, parthenolide, betulinic.acid",0.263603497723358,0.0462403082667712,FALSE +"H2126","Pearson.est","opioid receptor agonist",-0.41929,-1.09,0.346,1279,1,"ADL5859, salvinorin.a",0.460923901207223,0,FALSE +"H2126","Pearson.est","p38 MAPK inhibitor",0.20452,0.522,0.976,163,0.97,"SB.239063",0.0105501823333082,0.0132282657337552,FALSE +"H2126","Pearson.est","PARP inhibitor",-0.48365,-1.28,0.209,884,0.758,"E7449, niraparib, AZD2461, olaparib, AG.14361, talazoparib",0.679853713888946,0.120330794367946,FALSE +"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30197,-0.805,0.663,1169,0.913,"axitinib, lenvatinib, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.178486471595227,0.039529222465701,FALSE +"H2126","Pearson.est","phosphatase inhibitor",0.26838,0.679,0.852,174,0.905,"AS.1949490, sodium.stibogluconate",0.0695604052332999,0.0433514207947967,FALSE +"H2126","Pearson.est","phosphodiesterase inhibitor",0.31413,0.786,0.698,228,0.869,"papaverine, enoximone, EMD.53998",0.156144577376839,0.0609802235513335,FALSE +"H2126","Pearson.est","PI3K inhibitor",0.38658,0.982,0.469,513,0.851,"PI.103, PKI.179, NVP.BEZ235, BGT226, LY3023414, GDC.0980, SB.2343, buparlisib, PF.04691502, ZSTK.474, voxtalisib, PI.828, PI3K.IN.2, CUDC.907, PF.05212384",0.328827157284917,0.0700704399154121,FALSE +"H2126","Pearson.est","PLK inhibitor",0.39695,1.02,0.434,876,0.885,"HMN.214, BI.2536, volasertib, rigosertib, NMS.1286937, GSK461364, GW.843682X",0.362510270487489,0.0530567293021746,FALSE +"H2126","Pearson.est","potassium channel blocker",0.61348,1.56,0.0627,416,0.881,"ML133, ibutilide, mepivacaine, oleoylethanolamide, dofetilide",1.20273245916928,0.0550240915879521,FALSE +"H2126","Pearson.est","PPAR receptor agonist",-0.34702,-0.922,0.514,1418,0.973,"fenofibrate",0.289036881004724,0.0118871597316481,FALSE +"H2126","Pearson.est","progesterone receptor agonist",-0.74559,-1.99,0.00233,1221,0.11,"norgestrel, dienogest, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",2.63264407897398,0.958607314841775,TRUE +"H2126","Pearson.est","proteasome inhibitor",0.46115,1.18,0.259,426,1,"ONX.0914, MG.132, carfilzomib, delanzomib",0.586700235918748,0,FALSE +"H2126","Pearson.est","protein synthesis inhibitor",0.24022,0.612,0.924,465,0.954,"clofoctol, cycloheximide, thiostrepton, puromycin, brefeldin.a, azomycin..2.nitroimidazole., methacycline",0.0343280287798933,0.0204516252959049,FALSE +"H2126","Pearson.est","protein tyrosine kinase inhibitor",0.32569,0.82,0.654,332,0.862,"AV.412, NVP.TAE226, mubritinib, tyrphostin.A9",0.184422251675733,0.0644927341752872,FALSE +"H2126","Pearson.est","RAF inhibitor",0.48858,1.25,0.202,353,1,"SB.590885, vemurafenib, LGX818, dabrafenib, sorafenib, AZ.628",0.694648630553376,0,FALSE +"H2126","Pearson.est","RET tyrosine kinase inhibitor",-0.30117,-0.783,0.694,1374,0.921,"sunitinib",0.158640529545145,0.0357403698031511,FALSE +"H2126","Pearson.est","retinoid receptor agonist",0.33427,0.862,0.62,92,0.843,"LE.135",0.207608310501746,0.0741724253752577,FALSE +"H2126","Pearson.est","ribonucleotide reductase inhibitor",-0.39037,-1.03,0.395,1442,1,"pentostatin",0.40340290437354,0,FALSE +"H2126","Pearson.est","serotonin receptor agonist",-0.67538,-1.8,0.0232,1314,0.175,"ipsapirone, zolmitriptan, aripiprazole",1.6345120151091,0.756961951313706,TRUE +"H2126","Pearson.est","serotonin receptor antagonist",-0.39527,-1.07,0.358,1382,0.992,"lurasidone, aripiprazole",0.446116973356126,0.00348832784582135,FALSE +"H2126","Pearson.est","sodium channel blocker",0.42317,1.1,0.337,427,0.936,"brivaracetam, ajmaline, mepivacaine, butamben, mexiletine, cibenzoline",0.472370099128661,0.0287241512618947,FALSE +"H2126","Pearson.est","src inhibitor",-0.29537,-0.777,0.695,1258,0.902,"PP.2, masitinib",0.158015195409886,0.0447934624580583,FALSE +"H2126","Pearson.est","sterol demethylase inhibitor",0.37253,0.926,0.555,10,0.868,"chlormidazole",0.255707016877324,0.0614802748235081,FALSE +"H2126","Pearson.est","TGF beta receptor inhibitor",-0.47494,-1.25,0.205,1034,0.754,"adaprev, SB.431542, D.4476, SB.525334",0.688246138944246,0.122628654130226,FALSE +"H2126","Pearson.est","thymidylate synthase inhibitor",-0.34189,-0.919,0.533,493,0.935,"raltitrexed, ftorafur, doxifluridine, carmofur, capecitabine, trifluridine",0.273272790973428,0.0291883891274822,FALSE +"H2126","Pearson.est","topoisomerase inhibitor",0.33189,0.845,0.623,574,0.846,"mitoxantrone, idarubicin, exatecan.mesylate, doxorubicin, amsacrine, rubitecan, voreloxin, camptothecin, etoposide, valrubicin, epirubicin, daunorubicin, teniposide, topotecan, genz.644282",0.20551195334083,0.0726296369609765,FALSE +"H2126","Pearson.est","tubulin polymerization inhibitor",0.41393,1.05,0.395,510,0.955,"epothilone.b, BNC105, mebendazole, oxibendazole, CYT.997, vinorelbine, taltobulin, fenbendazole, verubulin, indibulin, parbendazole, plinabulin, KX2.391, podophyllotoxin, dolastatin.10",0.40340290437354,0.0199966284162537,FALSE +"H2126","Pearson.est","tyrosine kinase inhibitor",0.27987,0.713,0.82,502,0.907,"dasatinib, AV.412, bafetinib, NVP.TAE226, mubritinib, sorafenib, tyrphostin.A9, tivantinib, vandetanib, apatinib, GTP.14564, aminopurvalanol.a",0.0861861476162833,0.0423927129399047,FALSE +"H2126","Pearson.est","VEGFR inhibitor",0.22044,0.572,0.956,123,0.964,"BMS.690514, OSI.930, XL.647, SAR131675",0.0195421077238999,0.0159229660971692,FALSE +"H2126","Pearson.est","vitamin D receptor agonist",0.45554,1.17,0.288,541,1,"ercalcitriol, calcitriol, maxacalcitol, tacalcitol",0.540607512240769,0,FALSE +"HCC827","Pearson.est","EGFR inhibitor",0.26301,0.685,0.841,309,0.858,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, WZ.3146, BMS.690514, erlotinib, XL.647, AST.1306, brigatinib, lapatinib, canertinib, AZD8931",0.0752040042020878,0.0665127121512946,FALSE +"HCC827","Pearson.est","Abl kinase inhibitor",-0.25484,-0.667,0.851,1045,0.889,"imatinib, ponatinib, bosutinib, KW.2449, flumatinib",0.0700704399154121,0.0510982390297863,FALSE +"HCC827","Pearson.est","acetylcholine receptor agonist",0.25287,0.662,0.858,122,0.86,"xanomeline",0.0665127121512946,0.0655015487564323,FALSE +"HCC827","Pearson.est","acetylcholine receptor antagonist",-0.75125,-1.95,0.00589,1308,0.123,"dicycloverine, iododexetimide, methscopolamine",2.2298847052129,0.910094888560602,TRUE +"HCC827","Pearson.est","adenosine receptor antagonist",-0.32399,-0.817,0.674,1206,0.891,"sulmazole, istradefylline",0.17134010346468,0.0501222959631252,FALSE +"HCC827","Pearson.est","adrenergic receptor agonist",-0.39482,-1.03,0.395,1091,1,"oxymetazoline, xylazine, methyldopa, ritodrine, norepinephrine, isoetharine",0.40340290437354,0,FALSE +"HCC827","Pearson.est","adrenergic receptor antagonist",0.28592,0.77,0.731,215,0.944,"practolol, idazoxan, propranolol, vincamine",0.13608262304214,0.025028005701931,FALSE +"HCC827","Pearson.est","AKT inhibitor",0.35662,0.939,0.506,485,0.981,"MK.2206, triciribine, ONC201, AT7867, palomid.529, GSK2110183",0.295849483160201,0.0083309926200515,FALSE +"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.38868,-0.998,0.448,1233,1,"alectinib, DMH1, CEP.37440",0.348721986001856,0,FALSE +"HCC827","Pearson.est","androgen receptor antagonist",-0.70365,-1.8,0.0247,1169,0.257,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",1.60730304674033,0.590066876668705,FALSE +"HCC827","Pearson.est","antioxidant",-0.55092,-1.42,0.124,1155,0.575,"benfotiamine, trolox",0.906578314837765,0.24033215531037,FALSE +"HCC827","Pearson.est","AP inhibitor",0.66251,1.73,0.0291,59,0.497,"birinapant, GDC.0152",1.53610701101409,0.303643611266668,FALSE +"HCC827","Pearson.est","ATPase inhibitor",0.42821,1.13,0.316,251,1,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, NMS.873",0.500312917381596,0,FALSE +"HCC827","Pearson.est","Aurora kinase inhibitor",0.26592,0.702,0.801,506,0.862,"barasertib, barasertib.HQPA, MK.8745, MK.5108, alisertib, ENMD.2076, ZM.447439, CCT137690, PF.03814735, danusertib, SNS.314",0.0963674839157623,0.0644927341752872,FALSE +"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.3691,-0.959,0.497,1334,0.868,"azalomycin.b, dirithromycin",0.303643611266668,0.0614802748235081,FALSE +"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",0.3554,0.916,0.525,271,0.934,"lomefloxacin, finafloxacin, novobiocin",0.279840696594043,0.0296531237699066,FALSE +"HCC827","Pearson.est","BCL inhibitor",-0.37912,-0.977,0.449,1395,0.862,"gossypol, ABT.737",0.347753658996677,0.0644927341752872,FALSE +"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",0.31312,0.834,0.634,205,0.938,"metatinib, dasatinib, bafetinib",0.197910742118267,0.0277971616209356,FALSE +"HCC827","Pearson.est","benzodiazepine receptor agonist",0.44134,1.19,0.271,107,1,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.567030709125594,0,FALSE +"HCC827","Pearson.est","bromodomain inhibitor",-0.5128,-1.34,0.158,941,0.64,"JQ1...., bromosporine, I.BET151, PFI.1",0.801342913045577,0.193820026016113,FALSE +"HCC827","Pearson.est","calcium channel blocker",-0.33914,-0.887,0.574,1196,0.894,"efonidipine.monoethanolate, SR.33805, mibefradil",0.241088107602027,0.0486624812040823,FALSE +"HCC827","Pearson.est","CC chemokine receptor antagonist",-0.25746,-0.678,0.833,371,0.896,"UNBS.5162, ZK811752, RS.504393, MK.0812, SB.225002, navarixin, PF.04136309",0.0793549985932124,0.0476919903378748,FALSE +"HCC827","Pearson.est","CDK inhibitor",-0.27759,-0.711,0.803,1020,0.916,"AZD5438, R547, abemaciclib, indirubin, ribociclib, JNJ.7706621, BMS.265246, TG.02",0.095284454721319,0.0381045263321496,FALSE +"HCC827","Pearson.est","CHK inhibitor",-0.55802,-1.45,0.0985,1204,0.572,"SCH.900776, AZD7762, SB.218078",1.00656376950239,0.242603971206976,FALSE +"HCC827","Pearson.est","cyclooxygenase inhibitor",-0.40828,-1.03,0.415,1219,1,"acetylsalicylsalicylic.acid, AM.404, tryptanthrin, FR.122047, piroxicam, naproxen",0.381951903287907,0,FALSE +"HCC827","Pearson.est","cytochrome P450 inhibitor",0.58439,1.51,0.0838,260,0.746,"PF.4981517, morin, eplerenone",1.07675598136972,0.127261172527331,FALSE +"HCC827","Pearson.est","DNA alkylating agent",-0.36376,-0.939,0.506,1001,0.849,"streptozotocin, TH.302, carmustine, melphalan, satraplatin, cyclophosphamide, temozolomide",0.295849483160201,0.0710923097560473,FALSE +"HCC827","Pearson.est","DNA inhibitor",-0.25037,-0.654,0.84,1372,0.885,"pibenzimol, nithiamide",0.0757207139381184,0.0530567293021746,FALSE +"HCC827","Pearson.est","DNA methyltransferase inhibitor",0.5783,1.51,0.0716,579,0.746,"SGI.1027, azacitidine, decitabine, fdcyd, disulfiram",1.14508697769214,0.127261172527331,FALSE +"HCC827","Pearson.est","DNA polymerase inhibitor",0.33866,0.874,0.601,164,0.936,"foscarnet, cephalomannine, cidofovir",0.22112552799726,0.0287241512618947,FALSE +"HCC827","Pearson.est","DNA synthesis inhibitor",-0.2745,-0.72,0.792,1297,0.927,"altretamine, enocitabine",0.101274818410506,0.0329202658555029,FALSE +"HCC827","Pearson.est","dopamine receptor antagonist",-0.3781,-0.987,0.445,1042,0.951,"nemonapride, piperacetazine, mesoridazine, ziprasidone, remoxipride, paliperidone, amisulpride, lurasidone",0.351639989019068,0.0218194830625861,FALSE +"HCC827","Pearson.est","estrogen receptor agonist",-0.35343,-0.92,0.537,1107,0.857,"ethinyl.estradiol, estrone, erteberel",0.270025714300444,0.0670191780768018,FALSE +"HCC827","Pearson.est","estrogen receptor antagonist",-0.83708,-2.21,0,1301,0.0111,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.95467702121334,TRUE +"HCC827","Pearson.est","FGFR inhibitor",-0.2733,-0.702,0.792,393,0.907,"orantinib, regorafenib, erdafitinib, AZD4547, PD.173074, dovitinib, nintedanib, lenvatinib, MK.2461, lucitanib",0.101274818410506,0.0423927129399047,FALSE +"HCC827","Pearson.est","FLT3 inhibitor",-0.38518,-0.979,0.463,1149,0.892,"TG.101348, pacritinib, quizartinib, KW.2449, TG.02, sunitinib, lestaurtinib",0.334419008982047,0.0496351456238769,FALSE +"HCC827","Pearson.est","glucocorticoid receptor agonist",-0.44482,-1.16,0.28,926,0.967,"fluorometholone, ciclesonide, halobetasol.propionate, desonide, fludroxycortide, halcinonide, flumethasone, clobetasol.propionate, triamcinolone, triamcinolone.acetonide, prednisolone, rimexolone, beclomethasone.dipropionate, fluticasone.propionate, piretanide, prednisolone.acetate, fluocinolone.acetonide, hydrocortisone, dexamethasone.acetate, flumethasone.pivalate",0.552841968657781,0.0145735259169983,FALSE +"HCC827","Pearson.est","glutamate receptor antagonist",0.36181,0.958,0.469,222,1,"ACDPP, kynurenic.acid, tiletamine, CGP.37849",0.328827157284917,0,FALSE +"HCC827","Pearson.est","glycogen synthase kinase inhibitor",0.31447,0.842,0.625,70,0.961,"CHIR.99021",0.204119982655925,0.0172766123314547,FALSE +"HCC827","Pearson.est","growth factor receptor inhibitor",-0.58456,-1.51,0.0741,1244,0.498,"GSK1838705A, GW.441756, lestaurtinib",1.13018179202067,0.302770657240282,FALSE +"HCC827","Pearson.est","HCV inhibitor",0.40828,1.11,0.306,65,0.947,"daclatasvir",0.51427857351842,0.0236500209967266,FALSE +"HCC827","Pearson.est","HDAC inhibitor",0.43518,1.12,0.311,302,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, scriptaid, SB.939, mocetinostat, ACY.1215, entinostat, M.344",0.507239610973163,0,FALSE +"HCC827","Pearson.est","histamine receptor antagonist",-0.31435,-0.826,0.633,1037,0.925,"ICI.162846, cyproheptadine, ranitidine, terfenadine, tiotidine, ebastine, BF2.649, epinastine",0.198596289982645,0.0338582672609674,FALSE +"HCC827","Pearson.est","HMGCR inhibitor",0.27538,0.722,0.78,262,0.89,"atorvastatin, simvastatin",0.10790539730952,0.0506099933550872,FALSE +"HCC827","Pearson.est","HSP inhibitor",0.50456,1.31,0.18,246,1,"NMS.E973, BIIB021, PU.H71, NVP.AUY922, SNX.2112, ganetespib, SNX.5422",0.744727494896694,0,FALSE +"HCC827","Pearson.est","JAK inhibitor",-0.43865,-1.13,0.298,1149,0.926,"TG.101348, pacritinib, CEP.33779, filgotinib, AZD1480, TG.02, lestaurtinib",0.525783735923745,0.0333890133180656,FALSE +"HCC827","Pearson.est","KIT inhibitor",-0.30203,-0.777,0.741,1312,0.886,"vatalanib, telatinib, sunitinib, masitinib",0.130181792020672,0.0525662781129492,FALSE +"HCC827","Pearson.est","MDM inhibitor",-0.26642,-0.685,0.854,1022,0.907,"nutlin.3, CGM097, RITA",0.068542129310995,0.0423927129399047,FALSE +"HCC827","Pearson.est","MEK inhibitor",-0.32071,-0.825,0.628,1166,0.901,"refametinib, MEK162, nobiletin, BIX.02188, arctigenin",0.202040356262804,0.045275209020937,FALSE +"HCC827","Pearson.est","MET inhibitor",-0.58274,-1.55,0.0758,1101,0.483,"INC.280, PHA.665752, AMG458, NVP.BVU972",1.12033079436795,0.316052869248488,FALSE +"HCC827","Pearson.est","microtubule inhibitor",0.34902,0.913,0.538,165,0.896,"estramustine.phosphate, triclabendazole",0.269217724333611,0.0476919903378748,FALSE +"HCC827","Pearson.est","mTOR inhibitor",0.72123,1.95,0.0127,186,0.21,"deforolimus, PKI.179, PI.103, AZD8055, torin.1, temsirolimus, everolimus, LY3023414, NVP.BEZ235, AZD2014, MLN0128, PP242, sirolimus, GDC.0980, WYE.125132, SB.2343, torin.2",1.89619627904404,0.677780705266081,TRUE +"HCC827","Pearson.est","NFkB pathway inhibitor",-0.39424,-1.03,0.415,1032,1,"IKK.2.inhibitor.V, curcumin, bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.381951903287907,0,FALSE +"HCC827","Pearson.est","opioid receptor agonist",-0.4026,-1.02,0.397,1222,1,"ADL5859, salvinorin.a",0.401209493236885,0,FALSE +"HCC827","Pearson.est","p38 MAPK inhibitor",-0.33382,-0.867,0.603,1356,0.876,"skepinone.l",0.219682687859849,0.0574958938319193,FALSE +"HCC827","Pearson.est","PARP inhibitor",-0.53081,-1.36,0.153,887,0.651,"PJ.34, olaparib, AZD2461, niraparib, AG.14361, talazoparib",0.815308569182401,0.186419011431808,FALSE +"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.38669,-0.995,0.481,987,0.976,"crenolanib, nintedanib, lenvatinib, imatinib, ponatinib, motesanib, KI.8751, axitinib, vatalanib, telatinib, sunitinib, CP.673451, masitinib",0.317854923626168,0.0105501823333082,FALSE +"HCC827","Pearson.est","phosphatase inhibitor",-0.38176,-0.983,0.446,1194,0.92,"CID.5458317, menadione, alexidine",0.350665141287858,0.0362121726544447,FALSE +"HCC827","Pearson.est","phosphodiesterase inhibitor",0.29935,0.771,0.73,130,0.979,"papaverine, enoximone",0.136677139879544,0.00921730819686218,FALSE +"HCC827","Pearson.est","PI3K inhibitor",0.37876,0.964,0.478,365,1,"PKI.179, PI.103, BGT226, LY3023414, NVP.BEZ235, GDC.0980, SB.2343, voxtalisib, ZSTK.474, PF.04691502, buparlisib, PI3K.IN.2",0.320572103387881,0,FALSE +"HCC827","Pearson.est","PLK inhibitor",0.35878,0.938,0.498,931,0.932,"HMN.214, BI.2536, NMS.1286937, volasertib, rigosertib, GSK461364, GW.843682X",0.302770657240282,0.0305840876460186,FALSE +"HCC827","Pearson.est","potassium channel blocker",0.51654,1.36,0.155,505,1,"ML133, ibutilide, oleoylethanolamide, dofetilide, mepivacaine",0.809668301829709,0,FALSE +"HCC827","Pearson.est","PPAR receptor agonist",-0.29494,-0.754,0.756,1029,0.901,"clofibrate, S26948, fenofibrate",0.121478204498793,0.045275209020937,FALSE +"HCC827","Pearson.est","progesterone receptor agonist",-0.65779,-1.71,0.0264,1198,0.356,"dienogest, norgestrel, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",1.57839607313017,0.448550002027125,FALSE +"HCC827","Pearson.est","proteasome inhibitor",0.37144,0.971,0.478,143,1,"ONX.0914, MG.132",0.320572103387881,0,FALSE +"HCC827","Pearson.est","protein synthesis inhibitor",0.28833,0.737,0.765,430,0.93,"clofoctol, cycloheximide, brefeldin.a, thiostrepton, puromycin, methacycline, azomycin..2.nitroimidazole., chloramphenicol.palmitate",0.116338564846382,0.0315170514460649,FALSE +"HCC827","Pearson.est","protein tyrosine kinase inhibitor",-0.31362,-0.807,0.67,1329,0.883,"CP.724714, rheochrysidin",0.173925197299174,0.0540392964224314,FALSE +"HCC827","Pearson.est","RAF inhibitor",0.42764,1.13,0.296,403,1,"SB.590885, vemurafenib, sorafenib, AZ.628, LGX818, dabrafenib, regorafenib",0.528708288941061,0,FALSE +"HCC827","Pearson.est","RET tyrosine kinase inhibitor",-0.36107,-0.952,0.479,1368,0.851,"sunitinib",0.319664486585437,0.0700704399154121,FALSE +"HCC827","Pearson.est","retinoid receptor agonist",0.27733,0.734,0.78,73,0.903,"LE.135",0.10790539730952,0.0443122496864942,FALSE +"HCC827","Pearson.est","ribonucleotide reductase inhibitor",-0.33642,-0.868,0.569,1435,0.902,"pentostatin",0.244887733604929,0.0447934624580583,FALSE +"HCC827","Pearson.est","serotonin receptor agonist",-0.66458,-1.69,0.037,1153,0.324,"NAN.190, zolmitriptan, ipsapirone, aripiprazole",1.431798275933,0.489454989793388,FALSE +"HCC827","Pearson.est","serotonin receptor antagonist",-0.43997,-1.13,0.308,1152,0.926,"RS.16566, ziprasidone, paliperidone, lurasidone, aripiprazole",0.511449283499556,0.0333890133180656,FALSE +"HCC827","Pearson.est","sodium channel blocker",0.28044,0.741,0.76,384,0.956,"brivaracetam, ajmaline, cibenzoline, mexiletine, butamben",0.119186407719209,0.0195421077238999,FALSE +"HCC827","Pearson.est","src inhibitor",-0.45874,-1.17,0.281,1110,1,"bosutinib, PP.1, PP.2, masitinib",0.55129368009492,0,FALSE +"HCC827","Pearson.est","sterol demethylase inhibitor",0.36396,0.948,0.509,9,1,"chlormidazole",0.293282217663241,0,FALSE +"HCC827","Pearson.est","TGF beta receptor inhibitor",-0.60063,-1.55,0.0777,1026,0.483,"adaprev, repsox, SB.431542, SB.525334, D.4476",1.10957898119909,0.316052869248488,FALSE +"HCC827","Pearson.est","thymidylate synthase inhibitor",-0.30166,-0.782,0.691,435,0.901,"ftorafur, doxifluridine, raltitrexed, carmofur, capecitabine, trifluridine",0.160521952625802,0.045275209020937,FALSE +"HCC827","Pearson.est","topoisomerase inhibitor",0.29492,0.773,0.719,234,1,"mitoxantrone, idarubicin, doxorubicin, exatecan.mesylate, amsacrine",0.143271109617117,0,FALSE +"HCC827","Pearson.est","tubulin polymerization inhibitor",0.41592,1.07,0.379,444,0.978,"mebendazole, epothilone.b, BNC105, CYT.997, fenbendazole, oxibendazole, vinorelbine, taltobulin, verubulin, indibulin, dolastatin.10, plinabulin, podophyllotoxin, KX2.391",0.421360790031928,0.00966114521239857,FALSE +"HCC827","Pearson.est","tyrosine kinase inhibitor",0.26445,0.711,0.797,458,0.877,"AV.412, dasatinib, bafetinib, sorafenib, mubritinib, NVP.TAE226, tivantinib, regorafenib, GTP.14564, tyrphostin.A9, apatinib, PP.121",0.0985416786038876,0.0570004066339595,FALSE +"HCC827","Pearson.est","VEGFR inhibitor",-0.23412,-0.595,0.903,1088,0.922,"motesanib, MK.2461, AEE788, tivozanib, KI.8751, axitinib, foretinib, lucitanib, vatalanib, telatinib, sunitinib",0.0443122496864942,0.0352690789463706,FALSE +"HCC827","Pearson.est","vitamin D receptor agonist",0.4443,1.19,0.255,362,1,"ercalcitriol, calcitriol, maxacalcitol",0.593459819566045,0,FALSE +"CALU3","Pearson.est","EGFR inhibitor",0.41422,1.04,0.395,365,0.924,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, erlotinib, WZ.3146, BMS.690514, XL.647, canertinib, gefitinib, AST.1306, icotinib, BIBX.1382, PD.168393, BIBU.1361, AZD8931, brigatinib, rociletinib, pelitinib, afatinib",0.40340290437354,0.0343280287798933,FALSE +"CALU3","Pearson.est","Abl kinase inhibitor",-0.35237,-0.914,0.523,1138,0.879,"imatinib, ponatinib, KW.2449, flumatinib",0.281498311132726,0.0560111249262281,FALSE +"CALU3","Pearson.est","acetylcholine receptor agonist",0.33173,0.848,0.615,324,0.927,"xanomeline, oxiracetam",0.211124884224583,0.0329202658555029,FALSE +"CALU3","Pearson.est","acetylcholine receptor antagonist",-0.67636,-1.73,0.0336,1083,0.278,"hyoscyamine, darifenacin, methscopolamine, dicycloverine, iododexetimide",1.47366072261016,0.555955204081924,FALSE +"CALU3","Pearson.est","adenosine receptor antagonist",-0.32816,-0.869,0.55,1433,0.883,"istradefylline",0.259637310505756,0.0540392964224314,FALSE +"CALU3","Pearson.est","adrenergic receptor agonist",-0.41116,-1.08,0.357,1101,0.729,"A61603, oxymetazoline, terbutaline, xylazine, norepinephrine, isoetharine",0.447331783887807,0.137272471682025,FALSE +"CALU3","Pearson.est","adrenergic receptor antagonist",0.26246,0.684,0.844,217,0.967,"practolol, propranolol, idazoxan, vincamine",0.073657553374345,0.0145735259169983,FALSE +"CALU3","Pearson.est","AKT inhibitor",0.49628,1.28,0.201,412,0.905,"MK.2206, ONC201, triciribine, AT7867, GSK2110183, palomid.529",0.696803942579511,0.0433514207947967,FALSE +"CALU3","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41023,-1.1,0.314,1390,0.796,"CEP.37440, DMH1",0.503070351926785,0.0990869322623309,FALSE +"CALU3","Pearson.est","androgen receptor antagonist",-0.76229,-2,0.00218,1242,0.105,"flutamide, enzalutamide, cyproterone.acetate",2.6615435063954,0.978810700930062,TRUE +"CALU3","Pearson.est","antioxidant",-0.57359,-1.48,0.13,909,0.5,"rutin, mesna, benfotiamine, trolox",0.886056647693163,0.301029995663981,FALSE +"CALU3","Pearson.est","AP inhibitor",0.62025,1.58,0.0674,94,0.721,"birinapant, GDC.0152",1.17134010346468,0.142064735280571,FALSE +"CALU3","Pearson.est","ATPase inhibitor",0.55547,1.43,0.109,309,1,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873",0.962573502059376,0,FALSE +"CALU3","Pearson.est","Aurora kinase inhibitor",0.28721,0.739,0.749,469,0.918,"barasertib.HQPA, MK.8745, MK.5108, barasertib, ENMD.2076, alisertib, PF.03814735, danusertib, ZM.447439, CCT137690",0.125518182300534,0.0371573187987575,FALSE +"CALU3","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.44167,-1.16,0.279,1378,0.707,"azalomycin.b, dirithromycin",0.554395796726402,0.150580586203101,FALSE +"CALU3","Pearson.est","bacterial DNA gyrase inhibitor",0.40297,1.02,0.395,88,0.818,"lomefloxacin, finafloxacin",0.40340290437354,0.087246696328677,FALSE +"CALU3","Pearson.est","BCL inhibitor",-0.36302,-0.932,0.513,1415,0.908,"gossypol, ABT.737",0.289882634888184,0.0419141514789149,FALSE +"CALU3","Pearson.est","Bcr.Abl kinase inhibitor",-0.28058,-0.716,0.777,1138,0.939,"imatinib, ponatinib, flumatinib",0.109578981199086,0.0273344077338891,FALSE +"CALU3","Pearson.est","benzodiazepine receptor agonist",0.43168,1.08,0.356,40,0.95,"bentazepam, gamma.aminobutyric.acid, ivermectin",0.448550002027125,0.0222763947111523,FALSE +"CALU3","Pearson.est","bromodomain inhibitor",-0.4561,-1.21,0.224,1045,0.736,"bromosporine, I.BET151, PFI.1",0.649751981665837,0.133122185662501,FALSE +"CALU3","Pearson.est","calcium channel blocker",-0.41109,-1.08,0.338,1258,0.729,"efonidipine.monoethanolate, SR.33805, mibefradil",0.471083299722345,0.137272471682025,FALSE +"CALU3","Pearson.est","CC chemokine receptor antagonist",-0.27273,-0.714,0.805,393,0.919,"ZK811752, UNBS.5162, MK.0812, RS.504393, SB.225002, PF.04136309, navarixin",0.0942041196321315,0.0366844886138887,FALSE +"CALU3","Pearson.est","CDK inhibitor",-0.36872,-0.958,0.487,1077,0.886,"indirubin, R547, abemaciclib, AZD5438, ribociclib, BMS.265246, TG.02, JNJ.7706621",0.312471038785366,0.0525662781129492,FALSE +"CALU3","Pearson.est","CHK inhibitor",-0.54134,-1.46,0.0975,1214,0.487,"AZD7762, SCH.900776, SB.218078",1.01099538430146,0.312471038785366,FALSE +"CALU3","Pearson.est","cyclooxygenase inhibitor",-0.31535,-0.817,0.639,1062,0.897,"phenazone, indoprofen, AM.404, curcumin, tryptanthrin, acetylsalicylsalicylic.acid, FR.122047, naproxen, piroxicam",0.1944991418416,0.0472075569559079,FALSE +"CALU3","Pearson.est","cytochrome P450 inhibitor",0.52347,1.32,0.164,366,0.901,"PF.4981517, morin, eplerenone",0.785156151952302,0.045275209020937,FALSE +"CALU3","Pearson.est","DNA alkylating agent",-0.29814,-0.791,0.68,949,0.918,"melphalan, mitomycin.c, estramustine, satraplatin, TH.302, cyclophosphamide, streptozotocin, carmustine, temozolomide",0.167491087293764,0.0371573187987575,FALSE +"CALU3","Pearson.est","DNA inhibitor",-0.20073,-0.526,0.964,1360,0.968,"nithiamide, pibenzimol",0.0159229660971692,0.0141246426916063,FALSE +"CALU3","Pearson.est","DNA methyltransferase inhibitor",0.48752,1.26,0.227,745,0.775,"azacitidine, SGI.1027, fdcyd, RG108, disulfiram, decitabine",0.643974142806877,0.11069829749369,FALSE +"CALU3","Pearson.est","DNA polymerase inhibitor",0.41697,1.07,0.361,138,0.91,"cephalomannine, foscarnet, cidofovir",0.442492798094342,0.0409586076789064,FALSE +"CALU3","Pearson.est","DNA synthesis inhibitor",-0.27801,-0.727,0.807,1313,0.947,"altretamine, enocitabine",0.0931264652779296,0.0236500209967266,FALSE +"CALU3","Pearson.est","dopamine receptor antagonist",-0.2889,-0.76,0.764,1175,0.918,"mesoridazine, ziprasidone, paliperidone, lurasidone, amisulpride",0.11690664142431,0.0371573187987575,FALSE +"CALU3","Pearson.est","estrogen receptor agonist",0.22777,0.578,0.95,467,0.962,"PPT, equol, levonorgestrel, estradiol",0.0222763947111523,0.0168249279621871,FALSE +"CALU3","Pearson.est","estrogen receptor antagonist",-0.69967,-1.85,0.0161,1386,0.225,"danazol, fulvestrant, tamoxifen",1.79317412396815,0.647817481888638,TRUE +"CALU3","Pearson.est","FGFR inhibitor",-0.34937,-0.91,0.562,1174,0.857,"nintedanib, MK.2461, lucitanib",0.250263684430939,0.0670191780768018,FALSE +"CALU3","Pearson.est","FLT3 inhibitor",-0.38582,-1,0.442,1135,0.864,"quizartinib, ponatinib, pacritinib, KW.2449, TG.02, lestaurtinib, sunitinib",0.354577730650908,0.0634862575211067,FALSE +"CALU3","Pearson.est","glucocorticoid receptor agonist",-0.22533,-0.596,0.913,1011,1,"halobetasol.propionate, prednisolone.acetate, rimexolone, flumethasone, fluticasone.propionate, fluocinolone.acetonide, hydrocortisone, beclomethasone.dipropionate, piretanide, dexamethasone.acetate, flumethasone.pivalate",0.039529222465701,0,FALSE +"CALU3","Pearson.est","glutamate receptor antagonist",0.33437,0.842,0.609,188,0.901,"ACDPP, tiletamine, kynurenic.acid",0.215382707367125,0.045275209020937,FALSE +"CALU3","Pearson.est","glycogen synthase kinase inhibitor",0.30558,0.781,0.697,65,0.911,"CHIR.99021",0.156767221901991,0.0404816230270017,FALSE +"CALU3","Pearson.est","growth factor receptor inhibitor",-0.58993,-1.56,0.0774,1232,0.411,"GSK1838705A, GW.441756, lestaurtinib",1.11125903931711,0.386158178123931,FALSE +"CALU3","Pearson.est","HCV inhibitor",0.49607,1.26,0.21,101,0.775,"daclatasvir",0.677780705266081,0.11069829749369,FALSE +"CALU3","Pearson.est","HDAC inhibitor",0.42784,1.1,0.323,203,0.969,"nexturastat.a, chidamide, panobinostat, NSC.3852, belinostat, scriptaid, ACY.1215, SB.939",0.490797477668897,0.0136762229492347,FALSE +"CALU3","Pearson.est","histamine receptor antagonist",-0.21192,-0.547,0.947,1283,0.978,"ebastine, tiotidine, BF2.649",0.0236500209967266,0.00966114521239857,FALSE +"CALU3","Pearson.est","HMGCR inhibitor",0.55904,1.4,0.133,395,0.945,"atorvastatin, simvastatin, pitavastatin",0.876148359032914,0.0245681914907371,FALSE +"CALU3","Pearson.est","HSP inhibitor",0.40428,1.02,0.415,377,0.818,"BIIB021, PU.H71, NMS.E973, SNX.2112, ganetespib, SNX.5422, KW.2478, NVP.AUY922",0.381951903287907,0.087246696328677,FALSE +"CALU3","Pearson.est","JAK inhibitor",-0.26797,-0.697,0.838,1137,0.92,"AZD1480, filgotinib, pacritinib, TG.02, lestaurtinib",0.0767559813697235,0.0362121726544447,FALSE +"CALU3","Pearson.est","KIT inhibitor",-0.41327,-1.08,0.357,1291,0.729,"KI.8751, vatalanib, telatinib, sunitinib, masitinib",0.447331783887807,0.137272471682025,FALSE +"CALU3","Pearson.est","MDM inhibitor",0.45416,1.18,0.289,496,0.827,"serdemetan, idasanutlin, AMG.232",0.539102157243452,0.0824944904474534,FALSE +"CALU3","Pearson.est","MEK inhibitor",-0.32963,-0.88,0.569,1153,0.891,"refametinib, cobimetinib, MEK162, nobiletin, BIX.02188, arctigenin",0.244887733604929,0.0501222959631252,FALSE +"CALU3","Pearson.est","MET inhibitor",-0.86406,-2.27,0,1370,0.0086,"PHA.665752, INC.280, AMG458, NVP.BVU972",Inf,2.06550154875643,TRUE +"CALU3","Pearson.est","microtubule inhibitor",0.33939,0.857,0.614,136,0.948,"estramustine.phosphate, triclabendazole",0.211831628858832,0.0231916626619338,FALSE +"CALU3","Pearson.est","mTOR inhibitor",0.63925,1.63,0.0374,312,1,"PI.103, deforolimus, torin.1, AZD8055, PKI.179, PP242, LY3023414, NVP.BEZ235, everolimus, MLN0128, SB.2343, sirolimus, AZD2014, temsirolimus, WYE.125132, PF.04691502, GDC.0980, voxtalisib",1.42712839779952,0,FALSE +"CALU3","Pearson.est","NFkB pathway inhibitor",-0.4515,-1.16,0.289,1398,0.707,"parthenolide, Ro.106.9920, betulinic.acid",0.539102157243452,0.150580586203101,FALSE +"CALU3","Pearson.est","opioid receptor agonist",-0.37027,-0.974,0.448,1250,0.884,"ADL5859, salvinorin.a",0.348721986001856,0.0535477349869269,FALSE +"CALU3","Pearson.est","p38 MAPK inhibitor",-0.21069,-0.557,0.954,1121,0.995,"TAK.715, skepinone.l",0.0204516252959049,0.00217691925427455,FALSE +"CALU3","Pearson.est","PARP inhibitor",-0.61088,-1.61,0.0526,963,0.373,"niraparib, AG.14361, PJ.34, olaparib, AZD2461, talazoparib",1.27901425584626,0.428291168191312,FALSE +"CALU3","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.46091,-1.24,0.232,1138,0.778,"imatinib, ponatinib, nintedanib, axitinib, KI.8751, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.6345120151091,0.109020403010311,FALSE +"CALU3","Pearson.est","phosphatase inhibitor",-0.29115,-0.776,0.722,1022,0.915,"BVT.948, CID.5458317, menadione, alexidine",0.141462802430361,0.0385789059335517,FALSE +"CALU3","Pearson.est","phosphodiesterase inhibitor",0.29692,0.746,0.75,266,0.939,"papaverine, cilostamide, enoximone",0.1249387366083,0.0273344077338891,FALSE +"CALU3","Pearson.est","PI3K inhibitor",0.33304,0.857,0.602,312,0.948,"PI.103, PKI.179, LY3023414, BGT226, NVP.BEZ235, SB.2343, YM.201636, PF.04691502, GDC.0980, voxtalisib",0.220403508742175,0.0231916626619338,FALSE +"CALU3","Pearson.est","PLK inhibitor",0.30812,0.797,0.686,1004,0.916,"HMN.214, BI.2536, NMS.1286937, volasertib, rigosertib, GSK461364, GW.843682X",0.163675884293248,0.0381045263321496,FALSE +"CALU3","Pearson.est","potassium channel blocker",0.62024,1.61,0.0582,272,0.931,"ibutilide, ML133, oleoylethanolamide",1.23507701535011,0.0310503190186574,FALSE +"CALU3","Pearson.est","PPAR receptor agonist",0.3196,0.83,0.644,284,0.89,"pterostilbene, oleoylethanolamide, ciprofibrate",0.191114132640188,0.0506099933550872,FALSE +"CALU3","Pearson.est","progesterone receptor agonist",-0.46163,-1.21,0.219,1219,0.736,"nomegestrol.acetate, melengestrol.acetate, norethindrone.acetate, danazol",0.659555885159882,0.133122185662501,FALSE +"CALU3","Pearson.est","proteasome inhibitor",0.36266,0.923,0.509,162,0.898,"ONX.0914, MG.132",0.293282217663241,0.0467236633326956,FALSE +"CALU3","Pearson.est","protein synthesis inhibitor",0.35429,0.929,0.536,355,0.927,"clofoctol, cycloheximide, azomycin..2.nitroimidazole., chloramphenicol.palmitate, thiostrepton, brefeldin.a",0.27083521030723,0.0329202658555029,FALSE +"CALU3","Pearson.est","protein tyrosine kinase inhibitor",-0.34836,-0.916,0.551,1297,0.907,"BMS.599626, CP.724714, rheochrysidin",0.258848401148215,0.0423927129399047,FALSE +"CALU3","Pearson.est","RAF inhibitor",0.23752,0.589,0.913,202,0.981,"SB.590885, vemurafenib",0.039529222465701,0.0083309926200515,FALSE +"CALU3","Pearson.est","RET tyrosine kinase inhibitor",-0.46731,-1.25,0.198,1420,0.816,"sunitinib",0.703334809738469,0.0883098412461389,FALSE +"CALU3","Pearson.est","retinoid receptor agonist",0.26606,0.679,0.827,86,0.943,"LE.135",0.0824944904474534,0.0254883072626717,FALSE +"CALU3","Pearson.est","ribonucleotide reductase inhibitor",-0.32211,-0.835,0.636,1240,0.92,"clofarabine, pentostatin",0.196542884351586,0.0362121726544447,FALSE +"CALU3","Pearson.est","serotonin receptor agonist",-0.68738,-1.83,0.0218,1181,0.188,"NAN.190, ipsapirone, zolmitriptan, aripiprazole",1.6615435063954,0.72584215073632,TRUE +"CALU3","Pearson.est","serotonin receptor antagonist",-0.45122,-1.2,0.23,1186,0.709,"ziprasidone, paliperidone, RS.16566, lurasidone, aripiprazole",0.638272163982407,0.149353764816933,FALSE +"CALU3","Pearson.est","sodium channel blocker",0.21914,0.573,0.934,439,0.94,"brivaracetam, cibenzoline, ajmaline, butamben",0.0296531237699066,0.0268721464003014,FALSE +"CALU3","Pearson.est","src inhibitor",-0.54216,-1.42,0.121,1209,0.511,"PP.1, TG.100572, PP.2, masitinib",0.91721462968355,0.291579099865287,FALSE +"CALU3","Pearson.est","sterol demethylase inhibitor",0.40576,1.03,0.437,171,0.892,"chlormidazole, terconazole",0.359518563029578,0.0496351456238769,FALSE +"CALU3","Pearson.est","TGF beta receptor inhibitor",-0.61649,-1.69,0.0599,965,0.291,"SB.525334, adaprev, repsox, SB.431542, D.4476",1.22257317761069,0.536107011014093,FALSE +"CALU3","Pearson.est","thymidylate synthase inhibitor",0.3689,0.931,0.521,174,0.968,"ftorafur",0.283162276700476,0.0141246426916063,FALSE +"CALU3","Pearson.est","topoisomerase inhibitor",-0.22671,-0.591,0.95,1140,0.993,"TAS.103, SN.38, fleroxacin, dexrazoxane, irinotecan, beta.lapachone, etoposide.phosphate",0.0222763947111523,0.00305075150461883,FALSE +"CALU3","Pearson.est","tubulin polymerization inhibitor",0.45534,1.18,0.289,267,0.827,"BNC105, mebendazole, epothilone.b, oxibendazole, CYT.997, vinorelbine, verubulin, taltobulin, indibulin, fenbendazole, dolastatin.10",0.539102157243452,0.0824944904474534,FALSE +"CALU3","Pearson.est","tyrosine kinase inhibitor",0.23813,0.604,0.894,450,0.997,"AV.412, NVP.TAE226, dasatinib, GTP.14564, bafetinib, mubritinib, aminopurvalanol.a, PP.121, apatinib, sorafenib, tyrphostin.A9",0.0486624812040823,0.00130484168834428,FALSE +"CALU3","Pearson.est","VEGFR inhibitor",-0.32216,-0.828,0.668,1174,0.905,"nintedanib, MK.2461, axitinib, tivozanib, KI.8751, TG.100572, lucitanib, vatalanib, telatinib, foretinib, sunitinib",0.175223537524454,0.0433514207947967,FALSE +"CALU3","Pearson.est","vitamin D receptor agonist",0.53112,1.37,0.156,392,0.883,"maxacalcitol, ercalcitriol, calcitriol",0.806875401645538,0.0540392964224314,FALSE +"H2009","Pearson.est","EGFR inhibitor",0.43488,1.12,0.331,228,0.838,"CUDC.101, tyrphostin.AG.1478, ARRY.334543, BMS.690514, erlotinib, WZ.3146, XL.647, canertinib, BIBX.1382, gefitinib, brigatinib, AST.1306, PD.168393, BIBU.1361, icotinib",0.480172006224281,0.0767559813697235,FALSE +"H2009","Pearson.est","Abl kinase inhibitor",0.25271,0.658,0.871,240,0.909,"dasatinib, bafetinib, metatinib",0.0599818449923368,0.0414361167780325,FALSE +"H2009","Pearson.est","acetylcholine receptor agonist",0.24314,0.629,0.863,372,0.916,"xanomeline, oxiracetam",0.0639892042847904,0.0381045263321496,FALSE +"H2009","Pearson.est","acetylcholine receptor antagonist",-0.69679,-1.85,0.0127,1342,0.209,"iododexetimide, dicycloverine, methscopolamine",1.89619627904404,0.679853713888946,TRUE +"H2009","Pearson.est","adenosine receptor antagonist",-0.37679,-0.997,0.425,1431,1,"istradefylline",0.371611069949688,0,FALSE +"H2009","Pearson.est","adrenergic receptor agonist",-0.4167,-1.09,0.337,995,0.98,"midodrine, A61603, clenbuterol, terbutaline, xylazine, oxymetazoline, ritodrine, methyldopa, norepinephrine, isoetharine",0.472370099128661,0.00877392430750515,FALSE +"H2009","Pearson.est","adrenergic receptor antagonist",0.37567,0.948,0.508,188,0.767,"practolol, propranolol, idazoxan, vincamine",0.294136287716081,0.115204636051019,FALSE +"H2009","Pearson.est","AKT inhibitor",0.40784,1.06,0.382,470,0.769,"triciribine, MK.2206, ONC201, AT7867, palomid.529, GSK2110183",0.417936637088291,0.114073660198569,FALSE +"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.37674,-0.982,0.451,1381,0.949,"DMH1, CEP.37440",0.345823458122039,0.0227337875727074,FALSE +"H2009","Pearson.est","androgen receptor antagonist",-0.65152,-1.72,0.0448,1250,0.293,"flutamide, enzalutamide, cyproterone.acetate",1.34872198600186,0.533132379645891,FALSE +"H2009","Pearson.est","antioxidant",-0.62724,-1.64,0.0484,1190,0.28,"benfotiamine, trolox",1.31515463835559,0.552841968657781,FALSE +"H2009","Pearson.est","AP inhibitor",0.65559,1.69,0.0304,82,1,"birinapant, GDC.0152",1.51712641639125,0,FALSE +"H2009","Pearson.est","ATPase inhibitor",0.47335,1.2,0.263,268,1,"k.strophanthidin, oligomycin.a, evodiamine, blebbistatin...., ouabain",0.580044251510242,0,FALSE +"H2009","Pearson.est","Aurora kinase inhibitor",0.37072,0.954,0.476,491,0.788,"MK.5108, barasertib.HQPA, barasertib, MK.8745, ENMD.2076, alisertib, PF.03814735, ZM.447439, MLN.8054, CCT137690, danusertib, SNS.314",0.322393047279507,0.103473782510445,FALSE +"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.40125,-1.05,0.383,1341,0.971,"azalomycin.b, dirithromycin",0.416801226031377,0.0127807700919951,FALSE +"H2009","Pearson.est","bacterial DNA gyrase inhibitor",0.46438,1.22,0.231,176,1,"lomefloxacin, finafloxacin, novobiocin",0.636388020107856,0,FALSE +"H2009","Pearson.est","BCL inhibitor",0.3556,0.899,0.566,290,0.799,"oridonin, obatoclax, TW.37, HA14.1, venetoclax",0.247183568811729,0.0974532206860086,FALSE +"H2009","Pearson.est","Bcr.Abl kinase inhibitor",0.31124,0.798,0.692,240,0.8,"dasatinib, bafetinib, metatinib",0.159893905543242,0.0969100130080564,FALSE +"H2009","Pearson.est","benzodiazepine receptor agonist",0.40329,1.06,0.395,150,0.769,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.40340290437354,0.114073660198569,FALSE +"H2009","Pearson.est","bromodomain inhibitor",-0.52386,-1.37,0.135,965,0.616,"JQ1...., bromosporine, I.BET151, PFI.1",0.869666231504994,0.210419287835575,FALSE +"H2009","Pearson.est","calcium channel blocker",-0.35542,-0.944,0.508,1232,0.881,"SR.33805, efonidipine.monoethanolate, mibefradil",0.294136287716081,0.0550240915879521,FALSE +"H2009","Pearson.est","CC chemokine receptor antagonist",-0.27203,-0.703,0.796,392,0.957,"ZK811752, UNBS.5162, MK.0812, RS.504393, SB.225002, navarixin, PF.04136309",0.0990869322623309,0.0190880622231565,FALSE +"H2009","Pearson.est","CDK inhibitor",-0.27768,-0.706,0.808,1041,1,"indirubin, R547, AZD5438, abemaciclib, BMS.265246, JNJ.7706621, ribociclib, TG.02",0.0925886392254138,0,FALSE +"H2009","Pearson.est","CHK inhibitor",-0.50283,-1.32,0.193,1122,0.66,"SCH.900776, AZD7762, SB.218078",0.714442690992226,0.180456064458131,FALSE +"H2009","Pearson.est","cyclooxygenase inhibitor",-0.3588,-0.941,0.501,1236,0.855,"AM.404, acetylsalicylsalicylic.acid, piroxicam, FR.122047, tryptanthrin, naproxen",0.300162274132754,0.0680338852718274,FALSE +"H2009","Pearson.est","cytochrome P450 inhibitor",0.59583,1.53,0.0635,221,0.946,"PF.4981517, morin, eplerenone",1.19722627470802,0.0241088635982073,FALSE +"H2009","Pearson.est","DNA alkylating agent",-0.38619,-1.03,0.395,1001,0.969,"TH.302, estramustine, mitomycin.c, cyclophosphamide, streptozotocin, melphalan, satraplatin, carmustine, temozolomide",0.40340290437354,0.0136762229492347,FALSE +"H2009","Pearson.est","DNA inhibitor",-0.23036,-0.61,0.915,1118,0.91,"melphalan, carmustine, busulfan, nithiamide, pibenzimol",0.0385789059335517,0.0409586076789064,FALSE +"H2009","Pearson.est","DNA methyltransferase inhibitor",0.51456,1.33,0.175,706,1,"SGI.1027, decitabine, azacitidine, fdcyd, RG108, disulfiram",0.756961951313706,0,FALSE +"H2009","Pearson.est","DNA polymerase inhibitor",0.39041,0.997,0.433,124,0.817,"foscarnet, cephalomannine, cidofovir",0.363512103646635,0.0877779434675845,FALSE +"H2009","Pearson.est","DNA synthesis inhibitor",-0.25985,-0.69,0.846,1298,0.927,"altretamine, enocitabine",0.0726296369609765,0.0329202658555029,FALSE +"H2009","Pearson.est","dopamine receptor antagonist",-0.38065,-0.995,0.419,1185,0.962,"mesoridazine, remoxipride, ziprasidone, paliperidone, amisulpride, lurasidone",0.377785977033705,0.0168249279621871,FALSE +"H2009","Pearson.est","estrogen receptor agonist",-0.2893,-0.758,0.761,1395,1,"erteberel",0.118615343229427,0,FALSE +"H2009","Pearson.est","estrogen receptor antagonist",-0.81465,-2.11,0,1297,0.0655,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.18375870000822,TRUE +"H2009","Pearson.est","FGFR inhibitor",-0.35181,-0.916,0.532,1024,0.845,"nintedanib, lenvatinib, MK.2461, lucitanib",0.274088367704952,0.0731432910503077,FALSE +"H2009","Pearson.est","FLT3 inhibitor",-0.36909,-0.971,0.448,1103,0.896,"ponatinib, TG.101348, quizartinib, KW.2449, pacritinib, TG.02, lestaurtinib, sunitinib",0.348721986001856,0.0476919903378748,FALSE +"H2009","Pearson.est","glucocorticoid receptor agonist",-0.29471,-0.767,0.723,858,1,"clobetasol.propionate, triamcinolone.acetonide, fluorometholone, prednisolone, halcinonide, triamcinolone, fludroxycortide, halobetasol.propionate, rimexolone, flumethasone, beclomethasone.dipropionate, hydrocortisone, prednisolone.acetate, fluticasone.propionate, fluocinolone.acetonide, piretanide, dexamethasone.acetate, flumethasone.pivalate",0.140861702705469,0,FALSE +"H2009","Pearson.est","glutamate receptor antagonist",0.35455,0.916,0.532,159,0.798,"ACDPP, tiletamine, kynurenic.acid",0.274088367704952,0.0979971086492706,FALSE +"H2009","Pearson.est","glycogen synthase kinase inhibitor",0.38542,1,0.429,35,0.853,"CHIR.99021",0.367542707815276,0.069050968832477,FALSE +"H2009","Pearson.est","growth factor receptor inhibitor",-0.63283,-1.71,0.0238,1256,0.258,"GSK1838705A, GW.441756, lestaurtinib",1.62342304294349,0.58838029403677,FALSE +"H2009","Pearson.est","HCV inhibitor",0.45544,1.15,0.282,97,0.899,"daclatasvir",0.549750891680639,0.0462403082667712,FALSE +"H2009","Pearson.est","HDAC inhibitor",0.43208,1.1,0.326,440,0.828,"chidamide, nexturastat.a, panobinostat, NSC.3852, belinostat, ACY.1215, scriptaid, SB.939, entinostat, romidepsin, resminostat, givinostat, mocetinostat, M.344",0.486782399932061,0.0819696632151199,FALSE +"H2009","Pearson.est","histamine receptor antagonist",-0.26143,-0.67,0.849,1037,0.931,"ICI.162846, cyproheptadine, ranitidine, terfenadine, ebastine, tiotidine, epinastine, BF2.649",0.0710923097560473,0.0310503190186574,FALSE +"H2009","Pearson.est","HMGCR inhibitor",0.44893,1.18,0.279,388,0.901,"atorvastatin, simvastatin, pitavastatin",0.554395796726402,0.045275209020937,FALSE +"H2009","Pearson.est","HSP inhibitor",0.43233,1.13,0.306,319,0.878,"BIIB021, NMS.E973, PU.H71, SNX.2112, ganetespib, NVP.AUY922, SNX.5422",0.51427857351842,0.0565054840938974,FALSE +"H2009","Pearson.est","JAK inhibitor",-0.38191,-0.981,0.443,1132,0.911,"TG.101348, CEP.33779, filgotinib, pacritinib, AZD1480, TG.02, lestaurtinib",0.35359627377693,0.0404816230270017,FALSE +"H2009","Pearson.est","KIT inhibitor",-0.34271,-0.889,0.578,1116,0.839,"imatinib, lenvatinib, KI.8751, vatalanib, telatinib, masitinib, sunitinib",0.238072161579471,0.0762380391712997,FALSE +"H2009","Pearson.est","MDM inhibitor",0.49178,1.28,0.196,330,1,"serdemetan, idasanutlin, AMG.232",0.707743928643524,0,FALSE +"H2009","Pearson.est","MEK inhibitor",-0.2607,-0.668,0.834,1195,0.912,"MEK162, nobiletin, BIX.02188, arctigenin",0.0788339493622613,0.0400051616715838,FALSE +"H2009","Pearson.est","MET inhibitor",-0.7772,-2.01,0.00208,1252,0.0877,"PHA.665752, INC.280, NVP.BVU972, AMG458",2.68193666503724,1.05700040663396,TRUE +"H2009","Pearson.est","microtubule inhibitor",0.41839,1.08,0.369,410,0.822,"estramustine.phosphate, triclabendazole, podophyllotoxin, cabazitaxel",0.43297363384094,0.0851281824599496,FALSE +"H2009","Pearson.est","mTOR inhibitor",0.65926,1.68,0.0328,452,0.65,"deforolimus, PI.103, torin.1, AZD8055, PKI.179, PP242, everolimus, NVP.BEZ235, LY3023414, MLN0128, temsirolimus, SB.2343, AZD2014, sirolimus, GDC.0980, WYE.125132, torin.2, PF.04691502, WAY.600, voxtalisib, ku.0063794, palomid.529, PF.05212384",1.48412615628832,0.187086643357144,FALSE +"H2009","Pearson.est","NFkB pathway inhibitor",-0.36674,-0.964,0.478,1098,0.874,"IKK.2.inhibitor.V, bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.320572103387881,0.058488567365597,FALSE +"H2009","Pearson.est","opioid receptor agonist",-0.44068,-1.15,0.286,1259,0.882,"ADL5859, salvinorin.a",0.543633966870957,0.0545314148681803,FALSE +"H2009","Pearson.est","p38 MAPK inhibitor",-0.26527,-0.69,0.808,1112,0.927,"TAK.715, skepinone.l",0.0925886392254138,0.0329202658555029,FALSE +"H2009","Pearson.est","PARP inhibitor",-0.59762,-1.57,0.0701,958,0.348,"PJ.34, AZD2461, niraparib, olaparib, AG.14361, talazoparib",1.15428198203334,0.458420756053419,FALSE +"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.40835,-1.06,0.361,1103,0.999,"ponatinib, imatinib, axitinib, lenvatinib, KI.8751, vatalanib, telatinib, CP.673451, masitinib, sunitinib",0.442492798094342,0.000434511774017692,FALSE +"H2009","Pearson.est","phosphatase inhibitor",-0.28515,-0.748,0.762,1183,0.989,"CID.5458317, menadione, alexidine",0.1180450286604,0.0048037084028206,FALSE +"H2009","Pearson.est","phosphodiesterase inhibitor",-0.25122,-0.656,0.881,1219,0.905,"trequinsin, GSK256066, avanafil",0.0550240915879521,0.0433514207947967,FALSE +"H2009","Pearson.est","PI3K inhibitor",0.38183,0.98,0.447,485,0.775,"PI.103, PKI.179, NVP.BEZ235, BGT226, LY3023414, SB.2343, GDC.0980, ZSTK.474, PF.04691502, voxtalisib, buparlisib, YM.201636, PF.05212384, PI.828, CUDC.907, PI3K.IN.2",0.349692476868064,0.11069829749369,FALSE +"H2009","Pearson.est","PLK inhibitor",0.30743,0.807,0.682,1005,0.813,"HMN.214, BI.2536, NMS.1286937, GSK461364, volasertib, rigosertib, GW.843682X",0.166215625343521,0.0899094544059319,FALSE +"H2009","Pearson.est","potassium channel blocker",0.52059,1.33,0.184,534,1,"ibutilide, ML133, oleoylethanolamide, mepivacaine, dofetilide",0.735182176990464,0,FALSE +"H2009","Pearson.est","PPAR receptor agonist",-0.28328,-0.74,0.788,1377,0.975,"fenofibrate",0.103473782510445,0.0109953843014632,FALSE +"H2009","Pearson.est","progesterone receptor agonist",-0.54586,-1.42,0.116,1215,0.569,"dienogest, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",0.935542010773082,0.244887733604929,FALSE +"H2009","Pearson.est","proteasome inhibitor",0.38328,0.992,0.445,193,0.788,"ONX.0914, MG.132",0.351639989019068,0.103473782510445,FALSE +"H2009","Pearson.est","protein synthesis inhibitor",0.27134,0.69,0.833,512,0.897,"clofoctol, cycloheximide, thiostrepton, brefeldin.a, methacycline, chloramphenicol.palmitate, azomycin..2.nitroimidazole., puromycin",0.0793549985932124,0.0472075569559079,FALSE +"H2009","Pearson.est","protein tyrosine kinase inhibitor",-0.29371,-0.766,0.728,1206,1,"BMS.599626, CP.724714, rheochrysidin",0.137868620686963,0,FALSE +"H2009","Pearson.est","RAF inhibitor",0.33956,0.887,0.598,408,0.79,"SB.590885, vemurafenib, LGX818, sorafenib, AZ.628",0.223298816011589,0.102372908709559,FALSE +"H2009","Pearson.est","RET tyrosine kinase inhibitor",-0.5013,-1.3,0.181,1417,0.651,"sunitinib",0.742321425130815,0.186419011431808,FALSE +"H2009","Pearson.est","retinoid receptor agonist",0.33301,0.877,0.591,83,0.779,"LE.135",0.228412519118745,0.108462542327436,FALSE +"H2009","Pearson.est","ribonucleotide reductase inhibitor",-0.34258,-0.9,0.559,1440,0.847,"pentostatin",0.252588192113577,0.0721165896692931,FALSE +"H2009","Pearson.est","serotonin receptor agonist",-0.7053,-1.83,0.0117,1354,0.182,"zolmitriptan, ipsapirone, aripiprazole",1.93181413825384,0.739928612014925,TRUE +"H2009","Pearson.est","serotonin receptor antagonist",-0.48555,-1.27,0.203,1213,0.66,"RS.16566, ziprasidone, paliperidone, lurasidone, aripiprazole",0.692503962086787,0.180456064458131,FALSE +"H2009","Pearson.est","sodium channel blocker",0.31846,0.842,0.629,457,0.785,"brivaracetam, ajmaline, cibenzoline, butamben, mexiletine, mepivacaine",0.201349354554731,0.105130343254747,FALSE +"H2009","Pearson.est","src inhibitor",-0.35354,-0.934,0.487,1081,0.839,"TG.100572, PP.1, PP.2, masitinib",0.312471038785366,0.0762380391712997,FALSE +"H2009","Pearson.est","sterol demethylase inhibitor",0.33175,0.851,0.642,25,0.796,"chlormidazole",0.192464971931147,0.0990869322623309,FALSE +"H2009","Pearson.est","TGF beta receptor inhibitor",-0.63306,-1.66,0.0341,1016,0.291,"repsox, SB.431542, SB.525334, D.4476",1.4672456210075,0.536107011014093,FALSE +"H2009","Pearson.est","thymidylate synthase inhibitor",-0.26015,-0.704,0.815,1216,0.981,"trifluridine",0.0888423912600234,0.0083309926200515,FALSE +"H2009","Pearson.est","topoisomerase inhibitor",0.2849,0.752,0.741,346,0.84,"mitoxantrone, idarubicin, doxorubicin, exatecan.mesylate, amsacrine, epirubicin, voreloxin",0.130181792020672,0.0757207139381184,FALSE +"H2009","Pearson.est","tubulin polymerization inhibitor",0.4549,1.18,0.268,428,0.901,"epothilone.b, mebendazole, BNC105, oxibendazole, CYT.997, vinorelbine, verubulin, fenbendazole, indibulin, taltobulin, dolastatin.10, plinabulin, podophyllotoxin, KX2.391",0.571865205971211,0.045275209020937,FALSE +"H2009","Pearson.est","tyrosine kinase inhibitor",0.23289,0.606,0.908,447,0.912,"dasatinib, AV.412, NVP.TAE226, mubritinib, bafetinib, GTP.14564, sorafenib, vandetanib, PP.121, tyrphostin.A9",0.0419141514789149,0.0400051616715838,FALSE +"H2009","Pearson.est","VEGFR inhibitor",-0.24485,-0.63,0.881,1152,0.912,"axitinib, lenvatinib, MK.2461, KI.8751, tivozanib, vatalanib, lucitanib, telatinib, foretinib, sunitinib",0.0550240915879521,0.0400051616715838,FALSE +"H2009","Pearson.est","vitamin D receptor agonist",0.52393,1.35,0.149,354,1,"ercalcitriol, calcitriol, maxacalcitol",0.826813731587726,0,FALSE +"HCC4006","Pearson.est","EGFR inhibitor",0.37425,0.98,0.472,388,1,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, BMS.690514, erlotinib, WZ.3146, XL.647, canertinib, gefitinib, brigatinib, AST.1306, PD.168393, BIBU.1361, icotinib, BIBX.1382, pelitinib, afatinib, AZD8931, lapatinib, rociletinib",0.326058001365912,0,FALSE +"HCC4006","Pearson.est","Abl kinase inhibitor",0.26596,0.676,0.836,228,0.922,"dasatinib, metatinib, bafetinib",0.0777937225609836,0.0352690789463706,FALSE +"HCC4006","Pearson.est","acetylcholine receptor agonist",0.21941,0.568,0.95,133,0.972,"xanomeline",0.0222763947111523,0.0123337350737254,FALSE +"HCC4006","Pearson.est","acetylcholine receptor antagonist",-0.71373,-1.85,0.0114,1310,0.211,"dicycloverine, iododexetimide, methscopolamine",1.94309514866353,0.675717544702307,TRUE +"HCC4006","Pearson.est","adenosine receptor antagonist",-0.36098,-0.929,0.525,1427,0.87,"istradefylline",0.279840696594043,0.0604807473813815,FALSE +"HCC4006","Pearson.est","adrenergic receptor agonist",-0.4302,-1.12,0.318,1124,1,"xylazine, oxymetazoline, ritodrine, methyldopa, norepinephrine, isoetharine",0.497572880015567,0,FALSE +"HCC4006","Pearson.est","adrenergic receptor antagonist",0.30409,0.788,0.709,207,0.876,"practolol, idazoxan, propranolol, vincamine",0.149353764816933,0.0574958938319193,FALSE +"HCC4006","Pearson.est","AKT inhibitor",0.37209,0.967,0.48,473,0.95,"MK.2206, triciribine, ONC201, AT7867, palomid.529, GSK2110183",0.318758762624413,0.0222763947111523,FALSE +"HCC4006","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.40024,-1.06,0.387,1223,1,"alectinib, CEP.37440, DMH1",0.412289034981089,0,FALSE +"HCC4006","Pearson.est","androgen receptor antagonist",-0.75881,-1.96,0.00986,1231,0.132,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",2.00612308505879,0.87942606879415,TRUE +"HCC4006","Pearson.est","antioxidant",-0.68448,-1.77,0.0297,1197,0.218,"benfotiamine, trolox",1.52724355068279,0.661543506395395,TRUE +"HCC4006","Pearson.est","AP inhibitor",0.68634,1.77,0.0251,39,0.381,"birinapant, GDC.0152",1.60032627851896,0.419075024324381,FALSE +"HCC4006","Pearson.est","ATPase inhibitor",0.42021,1.1,0.328,365,1,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873",0.484126156288321,0,FALSE +"HCC4006","Pearson.est","Aurora kinase inhibitor",0.32072,0.834,0.637,514,0.858,"MK.5108, barasertib, MK.8745, barasertib.HQPA, alisertib, ENMD.2076, PF.03814735, ZM.447439, MLN.8054, CCT137690, SNS.314, danusertib",0.19586056766465,0.0665127121512946,FALSE +"HCC4006","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.36395,-0.927,0.532,1330,0.844,"azalomycin.b, dirithromycin",0.274088367704952,0.073657553374345,FALSE +"HCC4006","Pearson.est","bacterial DNA gyrase inhibitor",0.42883,1.15,0.282,333,1,"lomefloxacin, finafloxacin, novobiocin, trovafloxacin",0.549750891680639,0,FALSE +"HCC4006","Pearson.est","BCL inhibitor",-0.38411,-0.988,0.456,1414,1,"gossypol, ABT.737",0.341035157335565,0,FALSE +"HCC4006","Pearson.est","Bcr.Abl kinase inhibitor",0.32752,0.858,0.62,228,0.848,"dasatinib, metatinib, bafetinib",0.207608310501746,0.0716041477432862,FALSE +"HCC4006","Pearson.est","benzodiazepine receptor agonist",0.42389,1.09,0.34,124,1,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.468521082957745,0,FALSE +"HCC4006","Pearson.est","bromodomain inhibitor",-0.38352,-0.99,0.454,1171,1,"I.BET151, PFI.1",0.342944147142896,0,FALSE +"HCC4006","Pearson.est","calcium channel blocker",-0.34927,-0.9,0.529,1103,0.84,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.276544327964814,0.0757207139381184,FALSE +"HCC4006","Pearson.est","CC chemokine receptor antagonist",-0.25746,-0.673,0.854,371,0.927,"UNBS.5162, ZK811752, MK.0812, RS.504393, SB.225002, navarixin, PF.04136309",0.068542129310995,0.0329202658555029,FALSE +"HCC4006","Pearson.est","CDK inhibitor",-0.25177,-0.647,0.854,884,0.935,"PHA.793887, BMS.387032, PHA.848125, palbociclib, arcyriaflavin.a, AZD5438, indirubin, R547, abemaciclib, ribociclib, BMS.265246, JNJ.7706621, TG.02",0.068542129310995,0.0291883891274822,FALSE +"HCC4006","Pearson.est","CHK inhibitor",-0.41837,-1.07,0.363,1073,1,"SCH.900776, AZD7762, SB.218078",0.440093374963888,0,FALSE +"HCC4006","Pearson.est","cyclooxygenase inhibitor",-0.3837,-0.981,0.454,1201,0.979,"AM.404, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam, naproxen",0.342944147142896,0.00921730819686218,FALSE +"HCC4006","Pearson.est","cytochrome P450 inhibitor",0.63095,1.66,0.0459,205,0.486,"PF.4981517, morin, eplerenone",1.33818731446274,0.313363730737707,FALSE +"HCC4006","Pearson.est","DNA alkylating agent",-0.35938,-0.934,0.512,1042,0.891,"TH.302, streptozotocin, melphalan, carmustine, satraplatin, cyclophosphamide, temozolomide",0.290730039024169,0.0501222959631252,FALSE +"HCC4006","Pearson.est","DNA inhibitor",-0.25855,-0.676,0.856,1380,0.945,"nithiamide, pibenzimol",0.0675262353228468,0.0245681914907371,FALSE +"HCC4006","Pearson.est","DNA methyltransferase inhibitor",0.63078,1.65,0.0466,469,0.385,"azacitidine, decitabine, SGI.1027, fdcyd",1.33161408331,0.414539270491499,FALSE +"HCC4006","Pearson.est","DNA polymerase inhibitor",0.36547,0.962,0.481,155,0.866,"foscarnet, cephalomannine, cidofovir",0.317854923626168,0.0624821079826534,FALSE +"HCC4006","Pearson.est","DNA synthesis inhibitor",-0.26713,-0.706,0.814,1315,0.949,"altretamine, enocitabine",0.0893755951107988,0.0227337875727074,FALSE +"HCC4006","Pearson.est","dopamine receptor antagonist",-0.4069,-1.02,0.429,1190,1,"ziprasidone, remoxipride, mesoridazine, paliperidone, amisulpride, lurasidone",0.367542707815276,0,FALSE +"HCC4006","Pearson.est","estrogen receptor agonist",-0.34421,-0.889,0.572,1243,0.808,"estrone, erteberel",0.242603971206976,0.0925886392254138,FALSE +"HCC4006","Pearson.est","estrogen receptor antagonist",-0.8379,-2.17,0,1296,0.024,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.61978875828839,TRUE +"HCC4006","Pearson.est","FGFR inhibitor",-0.39011,-1.03,0.389,1049,1,"MK.2461, nintedanib, lenvatinib, lucitanib",0.410050398674292,0,FALSE +"HCC4006","Pearson.est","FLT3 inhibitor",-0.37259,-0.95,0.505,1164,0.927,"quizartinib, TG.101348, KW.2449, pacritinib, TG.02, sunitinib, lestaurtinib",0.296708621881339,0.0329202658555029,FALSE +"HCC4006","Pearson.est","glucocorticoid receptor agonist",-0.35798,-0.925,0.521,893,0.82,"desonide, halobetasol.propionate, fludroxycortide, clobetasol.propionate, triamcinolone.acetonide, triamcinolone, halcinonide, prednisolone, flumethasone, rimexolone, beclomethasone.dipropionate, prednisolone.acetate, fluticasone.propionate, fluocinolone.acetonide, piretanide, flumethasone.pivalate, hydrocortisone, dexamethasone.acetate",0.283162276700476,0.0861861476162833,FALSE +"HCC4006","Pearson.est","glutamate receptor antagonist",0.3356,0.861,0.616,192,0.877,"ACDPP, tiletamine, kynurenic.acid",0.210419287835575,0.0570004066339595,FALSE +"HCC4006","Pearson.est","glycogen synthase kinase inhibitor",0.39916,1.03,0.405,49,1,"CHIR.99021",0.392544976785331,0,FALSE +"HCC4006","Pearson.est","growth factor receptor inhibitor",-0.65521,-1.75,0.0278,1268,0.205,"GSK1838705A, GW.441756, lestaurtinib",1.55595520408192,0.688246138944246,TRUE +"HCC4006","Pearson.est","HCV inhibitor",0.38379,1,0.448,66,1,"daclatasvir",0.348721986001856,0,FALSE +"HCC4006","Pearson.est","HDAC inhibitor",0.43613,1.13,0.312,459,1,"nexturastat.a, chidamide, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, ACY.1215, entinostat, M.344, resminostat, romidepsin, mocetinostat, givinostat, trichostatin.a",0.505845405981557,0,FALSE +"HCC4006","Pearson.est","histamine receptor antagonist",-0.2654,-0.688,0.849,960,0.952,"lafutidine, cyproheptadine, ICI.162846, terfenadine, ranitidine, tiotidine, ebastine, BF2.649, epinastine",0.0710923097560473,0.0213630516155257,FALSE +"HCC4006","Pearson.est","HMGCR inhibitor",0.36445,0.975,0.469,229,0.987,"atorvastatin, simvastatin",0.328827157284917,0.00568284733036327,FALSE +"HCC4006","Pearson.est","HSP inhibitor",0.54031,1.43,0.0994,214,0.7,"BIIB021, NMS.E973, PU.H71, NVP.AUY922, ganetespib, SNX.2112, SNX.5422",1.00261361560269,0.154901959985743,FALSE +"HCC4006","Pearson.est","JAK inhibitor",-0.36271,-0.937,0.528,1109,0.919,"CEP.33779, TG.101348, pacritinib, filgotinib, AZD1480, TG.02, lestaurtinib",0.277366077466188,0.0366844886138887,FALSE +"HCC4006","Pearson.est","KIT inhibitor",-0.28973,-0.757,0.768,1102,0.919,"imatinib, lenvatinib, KI.8751, vatalanib, telatinib, sunitinib, masitinib",0.114638779968488,0.0366844886138887,FALSE +"HCC4006","Pearson.est","MDM inhibitor",-0.2418,-0.631,0.89,1012,0.93,"nutlin.3, CGM097, RITA",0.0506099933550872,0.0315170514460649,FALSE +"HCC4006","Pearson.est","MEK inhibitor",-0.27467,-0.71,0.805,1142,0.967,"refametinib, MEK162, BIX.02188, nobiletin, arctigenin",0.0942041196321315,0.0145735259169983,FALSE +"HCC4006","Pearson.est","MET inhibitor",-0.6435,-1.67,0.0511,1146,0.268,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.29157909986529,0.571865205971211,FALSE +"HCC4006","Pearson.est","microtubule inhibitor",0.38045,0.965,0.478,454,0.904,"estramustine.phosphate, triclabendazole, podophyllotoxin, cabazitaxel",0.320572103387881,0.0438315695246367,FALSE +"HCC4006","Pearson.est","mTOR inhibitor",0.69868,1.82,0.0149,226,0.552,"deforolimus, PI.103, AZD8055, torin.1, PKI.179, everolimus, temsirolimus, NVP.BEZ235, LY3023414, PP242, MLN0128, AZD2014, sirolimus, GDC.0980, SB.2343, torin.2, WYE.125132",1.82681373158773,0.258060922270801,FALSE +"HCC4006","Pearson.est","NFkB pathway inhibitor",-0.39249,-1.04,0.388,1226,1,"bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.411168274405793,0,FALSE +"HCC4006","Pearson.est","opioid receptor agonist",-0.43002,-1.11,0.323,1264,1,"ADL5859, salvinorin.a",0.490797477668897,0,FALSE +"HCC4006","Pearson.est","p38 MAPK inhibitor",-0.22983,-0.597,0.907,1302,0.94,"skepinone.l",0.0423927129399047,0.0268721464003014,FALSE +"HCC4006","Pearson.est","PARP inhibitor",-0.53205,-1.39,0.129,898,0.635,"niraparib, olaparib, PJ.34, AZD2461, AG.14361, talazoparib",0.889410289700751,0.197226274708024,FALSE +"HCC4006","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.37345,-0.971,0.478,1102,0.958,"imatinib, axitinib, nintedanib, lenvatinib, KI.8751, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.320572103387881,0.0186344909214556,FALSE +"HCC4006","Pearson.est","phosphatase inhibitor",-0.29531,-0.77,0.715,1157,0.922,"CID.5458317, menadione, alexidine",0.145693958198919,0.0352690789463706,FALSE +"HCC4006","Pearson.est","phosphodiesterase inhibitor",0.21587,0.571,0.95,489,0.999,"papaverine, enoximone, EMD.53998, zardaverine, cilostamide",0.0222763947111523,0.000434511774017692,FALSE +"HCC4006","Pearson.est","PI3K inhibitor",0.35094,0.897,0.552,185,0.877,"PI.103, PKI.179, NVP.BEZ235, LY3023414, BGT226, GDC.0980, SB.2343",0.258060922270801,0.0570004066339595,FALSE +"HCC4006","Pearson.est","PLK inhibitor",0.34074,0.872,0.614,957,0.892,"HMN.214, BI.2536, rigosertib, volasertib, GSK461364, NMS.1286937, GW.843682X",0.211831628858832,0.0496351456238769,FALSE +"HCC4006","Pearson.est","potassium channel blocker",0.56314,1.44,0.11,476,0.807,"ML133, ibutilide, oleoylethanolamide, dofetilide, mepivacaine",0.958607314841775,0.0931264652779296,FALSE +"HCC4006","Pearson.est","PPAR receptor agonist",-0.31713,-0.814,0.675,1406,0.896,"fenofibrate",0.170696227168975,0.0476919903378748,FALSE +"HCC4006","Pearson.est","progesterone receptor agonist",-0.55188,-1.44,0.108,1081,0.586,"norgestrel, dienogest, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",0.96657624451305,0.232102383981909,FALSE +"HCC4006","Pearson.est","proteasome inhibitor",0.36017,0.954,0.524,206,0.841,"ONX.0914, MG.132",0.280668713016273,0.0752040042020878,FALSE +"HCC4006","Pearson.est","protein synthesis inhibitor",0.28052,0.721,0.781,405,0.92,"clofoctol, cycloheximide, brefeldin.a, thiostrepton, puromycin, methacycline, azomycin..2.nitroimidazole.",0.1073489661227,0.0362121726544447,FALSE +"HCC4006","Pearson.est","protein tyrosine kinase inhibitor",-0.32632,-0.842,0.627,1363,0.871,"CP.724714, rheochrysidin",0.202732459169284,0.0599818449923368,FALSE +"HCC4006","Pearson.est","RAF inhibitor",0.40094,1.06,0.381,510,1,"SB.590885, vemurafenib, sorafenib, LGX818, AZ.628, dabrafenib, PLX.4720, regorafenib",0.419075024324381,0,FALSE +"HCC4006","Pearson.est","RET tyrosine kinase inhibitor",-0.37305,-0.959,0.469,1392,0.945,"sunitinib",0.328827157284917,0.0245681914907371,FALSE +"HCC4006","Pearson.est","retinoid receptor agonist",0.31541,0.812,0.684,63,0.865,"LE.135",0.164943898279884,0.0629838925351858,FALSE +"HCC4006","Pearson.est","ribonucleotide reductase inhibitor",-0.39798,-1.03,0.388,1441,1,"pentostatin",0.411168274405793,0,FALSE +"HCC4006","Pearson.est","serotonin receptor agonist",-0.70773,-1.82,0.0196,1348,0.194,"zolmitriptan, ipsapirone, aripiprazole",1.70774392864352,0.712198270069774,TRUE +"HCC4006","Pearson.est","serotonin receptor antagonist",-0.41143,-1.07,0.368,1397,1,"lurasidone, aripiprazole",0.434152181326482,0,FALSE +"HCC4006","Pearson.est","sodium channel blocker",0.29456,0.769,0.728,476,0.877,"brivaracetam, ajmaline, cibenzoline, mexiletine, butamben, mepivacaine",0.137868620686963,0.0570004066339595,FALSE +"HCC4006","Pearson.est","src inhibitor",-0.34039,-0.892,0.561,1055,0.827,"bosutinib, PP.1, PP.2, masitinib",0.251037138743839,0.0824944904474534,FALSE +"HCC4006","Pearson.est","sterol demethylase inhibitor",0.3633,0.951,0.504,10,0.809,"chlormidazole",0.297569463554475,0.0920514783877277,FALSE +"HCC4006","Pearson.est","TGF beta receptor inhibitor",-0.63419,-1.63,0.0567,1003,0.289,"adaprev, repsox, SB.431542, SB.525334, D.4476",1.24641694110709,0.539102157243452,FALSE +"HCC4006","Pearson.est","thymidylate synthase inhibitor",-0.32316,-0.806,0.667,466,0.885,"ftorafur, raltitrexed, doxifluridine, carmofur, capecitabine, trifluridine",0.175874166083451,0.0530567293021746,FALSE +"HCC4006","Pearson.est","topoisomerase inhibitor",0.26898,0.705,0.832,247,0.913,"mitoxantrone, idarubicin, doxorubicin, exatecan.mesylate, amsacrine",0.0798766737092761,0.039529222465701,FALSE +"HCC4006","Pearson.est","tubulin polymerization inhibitor",0.40614,1.06,0.365,463,1,"epothilone.b, BNC105, mebendazole, oxibendazole, CYT.997, vinorelbine, fenbendazole, taltobulin, verubulin, indibulin, dolastatin.10, podophyllotoxin, plinabulin, KX2.391",0.437707135543525,0,FALSE +"HCC4006","Pearson.est","tyrosine kinase inhibitor",-0.22203,-0.578,0.945,1363,0.935,"CP.724714, sunitinib, rheochrysidin",0.0245681914907371,0.0291883891274822,FALSE +"HCC4006","Pearson.est","VEGFR inhibitor",0.20175,0.534,0.963,100,0.965,"BMS.690514, OSI.930, SAR131675, XL.647",0.0163737128754655,0.0154726866562074,FALSE +"HCC4006","Pearson.est","vitamin D receptor agonist",0.48744,1.26,0.201,400,1,"ercalcitriol, calcitriol, maxacalcitol",0.696803942579511,0,FALSE +"HCC2279","Pearson.est","EGFR inhibitor",0.43915,1.11,0.333,373,0.925,"CUDC.101, ARRY.334543, BMS.690514, erlotinib, tyrphostin.AG.1478, XL.647, WZ.3146, canertinib, AST.1306, gefitinib, brigatinib, BIBU.1361, PD.168393, BIBX.1382, icotinib, pelitinib, afatinib, AZD8931, lapatinib, osimertinib",0.47755576649368,0.0338582672609674,FALSE +"HCC2279","Pearson.est","Abl kinase inhibitor",0.35954,0.925,0.545,222,0.888,"metatinib, dasatinib, bafetinib",0.263603497723358,0.051587034221399,FALSE +"HCC2279","Pearson.est","acetylcholine receptor agonist",0.2858,0.737,0.804,88,0.896,"xanomeline",0.0947439512515487,0.0476919903378748,FALSE +"HCC2279","Pearson.est","acetylcholine receptor antagonist",-0.74317,-1.98,0.00232,1280,0.122,"dicycloverine, methscopolamine, iododexetimide",2.6345120151091,0.913640169325252,TRUE +"HCC2279","Pearson.est","adenosine receptor antagonist",0.42261,1.07,0.372,128,0.871,"theophylline, PSB.1115",0.429457060118102,0.0599818449923368,FALSE +"HCC2279","Pearson.est","adrenergic receptor agonist",-0.4041,-1.07,0.36,1115,1,"xylazine, oxymetazoline, methyldopa, ritodrine, norepinephrine, isoetharine",0.443697499232713,0,FALSE +"HCC2279","Pearson.est","adrenergic receptor antagonist",0.3217,0.81,0.667,217,0.905,"practolol, idazoxan, vincamine, propranolol",0.175874166083451,0.0433514207947967,FALSE +"HCC2279","Pearson.est","AKT inhibitor",0.42308,1.07,0.368,485,0.871,"MK.2206, triciribine, AT7867, palomid.529, ONC201, GSK2110183",0.434152181326482,0.0599818449923368,FALSE +"HCC2279","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.28665,-0.754,0.741,1206,0.947,"alectinib, CEP.37440, DMH1",0.130181792020672,0.0236500209967266,FALSE +"HCC2279","Pearson.est","androgen receptor antagonist",-0.74422,-1.93,0.00696,1229,0.121,"flutamide, nilutamide, enzalutamide, cyproterone.acetate",2.15739076038944,0.91721462968355,TRUE +"HCC2279","Pearson.est","antioxidant",-0.62691,-1.72,0.0411,1149,0.214,"benfotiamine, trolox",1.38615817812393,0.669586226650809,TRUE +"HCC2279","Pearson.est","AP inhibitor",0.62245,1.54,0.0614,82,0.752,"birinapant, GDC.0152",1.21183162885883,0.123782159408358,FALSE +"HCC2279","Pearson.est","ATPase inhibitor",0.45017,1.14,0.287,321,0.97,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, NMS.873, blebbistatin....",0.542118103266008,0.0132282657337552,FALSE +"HCC2279","Pearson.est","Aurora kinase inhibitor",0.40273,1.03,0.415,438,0.839,"MK.8745, barasertib.HQPA, barasertib, alisertib, ENMD.2076, MK.5108, ZM.447439, CCT137690, PF.03814735, danusertib, SNS.314",0.381951903287907,0.0762380391712997,FALSE +"HCC2279","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.30116,0.759,0.735,152,0.91,"tedizolid, azithromycin",0.133712660915805,0.0409586076789064,FALSE +"HCC2279","Pearson.est","bacterial DNA gyrase inhibitor",0.30787,0.784,0.718,457,0.896,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.1438755557577,0.0476919903378748,FALSE +"HCC2279","Pearson.est","BCL inhibitor",0.35658,0.903,0.571,331,0.871,"oridonin, obatoclax, TW.37, venetoclax, HA14.1",0.243363891754152,0.0599818449923368,FALSE +"HCC2279","Pearson.est","Bcr.Abl kinase inhibitor",0.41744,1.07,0.377,222,0.871,"metatinib, dasatinib, bafetinib",0.423658649794207,0.0599818449923368,FALSE +"HCC2279","Pearson.est","benzodiazepine receptor agonist",0.45361,1.18,0.256,116,1,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.59176003468815,0,FALSE +"HCC2279","Pearson.est","bromodomain inhibitor",-0.35488,-0.931,0.53,1120,0.929,"I.BET151, PFI.1",0.275724130399211,0.0319842860063582,FALSE +"HCC2279","Pearson.est","calcium channel blocker",-0.31383,-0.828,0.626,1100,0.946,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.20342566678957,0.0241088635982073,FALSE +"HCC2279","Pearson.est","CC chemokine receptor antagonist",-0.30396,-0.811,0.663,438,0.91,"UNBS.5162, ZK811752, MK.0812, RS.504393, SB.225002, navarixin, PF.04136309",0.178486471595227,0.0409586076789064,FALSE +"HCC2279","Pearson.est","CDK inhibitor",0.22682,0.578,0.934,437,0.937,"alvocidib, NU6027, P276.00, AT.7519, dinaciclib, CR8..R., kenpaullone, aminopurvalanol.a",0.0296531237699066,0.0282604091122217,FALSE +"HCC2279","Pearson.est","CHK inhibitor",-0.37942,-1.02,0.417,1148,0.972,"SCH.900776, AZD7762, SB.218078",0.379863945026242,0.0123337350737254,FALSE +"HCC2279","Pearson.est","cyclooxygenase inhibitor",-0.40169,-1.05,0.366,1228,1,"acetylsalicylsalicylic.acid, AM.404, tryptanthrin, FR.122047, piroxicam, naproxen",0.436518914605589,0,FALSE +"HCC2279","Pearson.est","cytochrome P450 inhibitor",0.57356,1.42,0.115,253,0.871,"PF.4981517, morin, eplerenone",0.939302159646388,0.0599818449923368,FALSE +"HCC2279","Pearson.est","DNA alkylating agent",-0.29599,-0.782,0.714,1041,0.933,"melphalan, carmustine, streptozotocin, satraplatin, cyclophosphamide, temozolomide",0.146301788223826,0.0301183562535,FALSE +"HCC2279","Pearson.est","DNA inhibitor",-0.23623,-0.617,0.903,1041,0.929,"melphalan, metronidazole, carmustine, busulfan, pibenzimol, nithiamide",0.0443122496864942,0.0319842860063582,FALSE +"HCC2279","Pearson.est","DNA methyltransferase inhibitor",0.65815,1.65,0.0358,392,0.809,"azacitidine, SGI.1027, decitabine, fdcyd",1.44611697335613,0.0920514783877277,FALSE +"HCC2279","Pearson.est","DNA polymerase inhibitor",0.46568,1.17,0.276,210,1,"foscarnet, cephalomannine, cidofovir, idoxuridine",0.559090917934782,0,FALSE +"HCC2279","Pearson.est","DNA synthesis inhibitor",-0.34519,-0.916,0.522,1406,0.919,"altretamine, enocitabine",0.282329496997738,0.0366844886138887,FALSE +"HCC2279","Pearson.est","dopamine receptor antagonist",-0.37798,-0.995,0.422,1028,0.922,"clebopride, nemonapride, mesoridazine, ziprasidone, paliperidone, remoxipride, lurasidone, amisulpride",0.374687549038326,0.0352690789463706,FALSE +"HCC2279","Pearson.est","estrogen receptor agonist",-0.31267,-0.812,0.643,1130,0.941,"ethinyl.estradiol, estrone, erteberel",0.191789027075778,0.0264103765727431,FALSE +"HCC2279","Pearson.est","estrogen receptor antagonist",-0.79704,-2.1,0.00248,1307,0.095,"danazol, raloxifene, fulvestrant, tamoxifen",2.60554831917378,1.02227639471115,TRUE +"HCC2279","Pearson.est","FGFR inhibitor",-0.26217,-0.686,0.82,377,0.879,"orantinib, regorafenib, erdafitinib, AZD4547, PD.173074, dovitinib, nintedanib, MK.2461, lenvatinib, lucitanib",0.0861861476162833,0.0560111249262281,FALSE +"HCC2279","Pearson.est","FLT3 inhibitor",-0.28707,-0.744,0.731,1171,0.932,"TG.101348, KW.2449, quizartinib, TG.02, lestaurtinib, sunitinib",0.13608262304214,0.0305840876460186,FALSE +"HCC2279","Pearson.est","glucocorticoid receptor agonist",-0.35201,-0.938,0.518,928,0.958,"clobetasol.propionate, ciclesonide, fludroxycortide, flumethasone, halcinonide, desonide, triamcinolone, rimexolone, prednisolone, triamcinolone.acetonide, beclomethasone.dipropionate, prednisolone.acetate, fluticasone.propionate, fluocinolone.acetonide, piretanide, dexamethasone.acetate, flumethasone.pivalate, hydrocortisone",0.285670240254767,0.0186344909214556,FALSE +"HCC2279","Pearson.est","glutamate receptor antagonist",0.33881,0.884,0.592,316,0.849,"ACDPP, tiletamine, kynurenic.acid, CGP.37849",0.22767829327708,0.0710923097560473,FALSE +"HCC2279","Pearson.est","glycogen synthase kinase inhibitor",0.41156,1.05,0.367,33,0.831,"CHIR.99021",0.435333935747911,0.080398976215889,FALSE +"HCC2279","Pearson.est","growth factor receptor inhibitor",-0.49468,-1.31,0.16,1353,0.664,"GW.441756, lestaurtinib",0.795880017344075,0.177831920631982,FALSE +"HCC2279","Pearson.est","HCV inhibitor",0.36262,0.924,0.526,70,0.858,"daclatasvir",0.279014255846261,0.0665127121512946,FALSE +"HCC2279","Pearson.est","HDAC inhibitor",0.47665,1.21,0.249,288,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, ACY.1215, M.344, entinostat, resminostat",0.603800652904264,0,FALSE +"HCC2279","Pearson.est","histamine receptor antagonist",-0.27106,-0.714,0.816,1019,0.891,"ICI.162846, lafutidine, cyproheptadine, tiotidine, terfenadine, ebastine, ranitidine, BF2.649, epinastine",0.0883098412461389,0.0501222959631252,FALSE +"HCC2279","Pearson.est","HMGCR inhibitor",0.35543,0.89,0.586,243,0.866,"atorvastatin, simvastatin",0.232102383981909,0.0624821079826534,FALSE +"HCC2279","Pearson.est","HSP inhibitor",0.58732,1.5,0.0687,204,0.73,"BIIB021, NMS.E973, PU.H71, NVP.AUY922, SNX.2112, ganetespib, SNX.5422",1.16304326294045,0.136677139879544,FALSE +"HCC2279","Pearson.est","JAK inhibitor",-0.30761,-0.832,0.638,1171,0.976,"TG.101348, CEP.33779, filgotinib, AZD1480, TG.02, lestaurtinib",0.195179321278838,0.0105501823333082,FALSE +"HCC2279","Pearson.est","KIT inhibitor",0.26336,0.683,0.848,218,0.922,"midostaurin, OSI.930, dasatinib, sorafenib",0.0716041477432862,0.0352690789463706,FALSE +"HCC2279","Pearson.est","MDM inhibitor",-0.27601,-0.742,0.762,398,0.906,"serdemetan, idasanutlin, AMG.232, nutlin.3, CGM097, RITA",0.1180450286604,0.0428718023231869,FALSE +"HCC2279","Pearson.est","MEK inhibitor",-0.31578,-0.843,0.622,1136,0.994,"PD.318088, nobiletin, refametinib, BIX.02188, MEK162, arctigenin",0.206209615309181,0.00261361560268669,FALSE +"HCC2279","Pearson.est","MET inhibitor",-0.63067,-1.68,0.0302,1065,0.227,"PF.04217903, INC.280, PHA.665752, NVP.BVU972, AMG458",1.51999305704285,0.643974142806877,TRUE +"HCC2279","Pearson.est","microtubule inhibitor",0.44887,1.15,0.308,460,1,"estramustine.phosphate, triclabendazole, D.64131, cabazitaxel, podophyllotoxin",0.511449283499556,0,FALSE +"HCC2279","Pearson.est","mTOR inhibitor",0.69425,1.76,0.0186,198,0.777,"deforolimus, PI.103, AZD8055, PKI.179, everolimus, temsirolimus, torin.1, NVP.BEZ235, LY3023414, MLN0128, AZD2014, PP242, torin.2, GDC.0980, WYE.125132, sirolimus",1.73048705578208,0.109578981199086,FALSE +"HCC2279","Pearson.est","NFkB pathway inhibitor",-0.36824,-0.981,0.47,1210,0.905,"Ro.106.9920, bindarit, parthenolide, betulinic.acid",0.327902142064283,0.0433514207947967,FALSE +"HCC2279","Pearson.est","opioid receptor agonist",-0.42367,-1.11,0.344,1278,1,"ADL5859, salvinorin.a",0.46344155742847,0,FALSE +"HCC2279","Pearson.est","p38 MAPK inhibitor",-0.21537,-0.581,0.936,1015,0.934,"CMPD.1, TAK.715, skepinone.l",0.0287241512618947,0.0296531237699066,FALSE +"HCC2279","Pearson.est","PARP inhibitor",-0.55559,-1.46,0.112,986,0.504,"olaparib, niraparib, AZD2461, AG.14361, talazoparib",0.950781977329818,0.297569463554475,FALSE +"HCC2279","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.27351,-0.707,0.804,1118,0.875,"axitinib, KI.8751, lenvatinib, telatinib, vatalanib, CP.673451, sunitinib, masitinib",0.0947439512515487,0.0579919469776868,FALSE +"HCC2279","Pearson.est","phosphatase inhibitor",-0.27238,-0.721,0.751,1424,0.909,"alexidine",0.124360062995832,0.0414361167780325,FALSE +"HCC2279","Pearson.est","phosphodiesterase inhibitor",0.26533,0.678,0.843,428,0.907,"papaverine, enoximone, EMD.53998, cilostamide",0.0741724253752577,0.0423927129399047,FALSE +"HCC2279","Pearson.est","PI3K inhibitor",0.37559,0.952,0.504,371,0.9,"PI.103, PKI.179, BGT226, NVP.BEZ235, LY3023414, GDC.0980, ZSTK.474, voxtalisib, buparlisib, SB.2343, PF.04691502",0.297569463554475,0.0457574905606751,FALSE +"HCC2279","Pearson.est","PLK inhibitor",0.42401,1.05,0.402,837,0.831,"HMN.214, BI.2536, volasertib, NMS.1286937, rigosertib, GSK461364, GW.843682X",0.39577394691553,0.080398976215889,FALSE +"HCC2279","Pearson.est","potassium channel blocker",0.6142,1.54,0.059,397,0.752,"ML133, ibutilide, mepivacaine, dofetilide, oleoylethanolamide",1.22914798835786,0.123782159408358,FALSE +"HCC2279","Pearson.est","PPAR receptor agonist",-0.39076,-1.04,0.377,1147,0.984,"clofibrate, S26948, fenofibrate",0.423658649794207,0.00700490156865849,FALSE +"HCC2279","Pearson.est","progesterone receptor agonist",-0.69261,-1.81,0.0183,1209,0.161,"dienogest, norgestrel, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",1.73754891026957,0.79317412396815,TRUE +"HCC2279","Pearson.est","proteasome inhibitor",0.437,1.12,0.32,135,0.959,"ONX.0914, MG.132",0.494850021680094,0.0181813928293364,FALSE +"HCC2279","Pearson.est","protein synthesis inhibitor",0.24222,0.613,0.901,585,0.952,"clofoctol, cycloheximide, puromycin, thiostrepton, brefeldin.a, methacycline, azomycin..2.nitroimidazole., anguidine, homoharringtonine, chloramphenicol.palmitate",0.045275209020937,0.0213630516155257,FALSE +"HCC2279","Pearson.est","protein tyrosine kinase inhibitor",0.3168,0.806,0.71,357,0.885,"AV.412, NVP.TAE226, mubritinib, tyrphostin.A9",0.148741651280925,0.0530567293021746,FALSE +"HCC2279","Pearson.est","RAF inhibitor",0.47626,1.21,0.243,434,1,"SB.590885, vemurafenib, sorafenib, dabrafenib, LGX818, AZ.628, regorafenib",0.614393726401688,0,FALSE +"HCC2279","Pearson.est","RET tyrosine kinase inhibitor",0.32383,0.828,0.667,481,0.927,"sorafenib, regorafenib, apatinib, vandetanib",0.175874166083451,0.0329202658555029,FALSE +"HCC2279","Pearson.est","retinoid receptor agonist",0.29587,0.752,0.755,76,0.897,"LE.135",0.122053048370812,0.0472075569559079,FALSE +"HCC2279","Pearson.est","ribonucleotide reductase inhibitor",-0.37302,-1.01,0.433,1437,0.939,"pentostatin",0.363512103646635,0.0273344077338891,FALSE +"HCC2279","Pearson.est","serotonin receptor agonist",-0.68958,-1.82,0.0167,1213,0.189,"NAN.190, zolmitriptan, ipsapirone, aripiprazole",1.77728352885242,0.723538195826756,TRUE +"HCC2279","Pearson.est","serotonin receptor antagonist",-0.39765,-1.06,0.39,1380,1,"lurasidone, aripiprazole",0.408935392973501,0,FALSE +"HCC2279","Pearson.est","sodium channel blocker",0.37315,0.964,0.471,456,0.95,"brivaracetam, ajmaline, butamben, mepivacaine, cibenzoline, mexiletine",0.326979092871104,0.0222763947111523,FALSE +"HCC2279","Pearson.est","src inhibitor",-0.32003,-0.854,0.613,1272,1,"PP.2, masitinib",0.212539525481585,0,FALSE +"HCC2279","Pearson.est","sterol demethylase inhibitor",0.37122,0.933,0.52,11,0.906,"chlormidazole",0.283996656365201,0.0428718023231869,FALSE +"HCC2279","Pearson.est","TGF beta receptor inhibitor",-0.51439,-1.31,0.172,1006,0.664,"repsox, adaprev, SB.431542, D.4476, SB.525334",0.764471553092451,0.177831920631982,FALSE +"HCC2279","Pearson.est","thymidylate synthase inhibitor",0.3766,0.952,0.49,671,0.9,"ftorafur, raltitrexed, doxifluridine, carmofur, capecitabine",0.309803919971486,0.0457574905606751,FALSE +"HCC2279","Pearson.est","topoisomerase inhibitor",0.27081,0.698,0.836,157,0.926,"mitoxantrone, idarubicin, doxorubicin, exatecan.mesylate",0.0777937225609836,0.0333890133180656,FALSE +"HCC2279","Pearson.est","tubulin polymerization inhibitor",0.45344,1.14,0.302,566,0.97,"epothilone.b, mebendazole, BNC105, oxibendazole, CYT.997, vinorelbine, fenbendazole, taltobulin, verubulin, indibulin, plinabulin, parbendazole, dolastatin.10, KX2.391, podophyllotoxin, combretastatin.A.4, vindesine, paclitaxel, ABT.751",0.519993057042849,0.0132282657337552,FALSE +"HCC2279","Pearson.est","tyrosine kinase inhibitor",0.32461,0.821,0.686,517,0.912,"AV.412, dasatinib, NVP.TAE226, sorafenib, bafetinib, mubritinib, tivantinib, tyrphostin.A9, regorafenib, apatinib, aminopurvalanol.a, vandetanib, PP.121, GTP.14564",0.163675884293248,0.0400051616715838,FALSE +"HCC2279","Pearson.est","VEGFR inhibitor",0.23293,0.587,0.936,223,0.952,"BMS.690514, OSI.930, XL.647, SAR131675, sorafenib, ENMD.2076",0.0287241512618947,0.0213630516155257,FALSE +"HCC2279","Pearson.est","vitamin D receptor agonist",0.55351,1.4,0.117,570,0.812,"ercalcitriol, calcitriol, maxacalcitol, tacalcitol, doxercalciferol",0.931814138253838,0.0904439707588247,FALSE +"H520","Pearson.est","EGFR inhibitor",0.3785,1,0.438,413,1,"CUDC.101, ARRY.334543, BMS.690514, tyrphostin.AG.1478, erlotinib, XL.647, brigatinib, WZ.3146, canertinib, gefitinib, PD.168393, BIBU.1361, icotinib, AST.1306, BIBX.1382, afatinib, pelitinib, vandetanib, lapatinib, rociletinib, osimertinib",0.3585258894959,0,FALSE +"H520","Pearson.est","Abl kinase inhibitor",0.38038,0.992,0.464,149,0.918,"dasatinib, metatinib, bafetinib",0.333482019445119,0.0371573187987575,FALSE +"H520","Pearson.est","acetylcholine receptor agonist",-0.21849,-0.574,0.934,1154,1,"pilocarpine, nicotine",0.0296531237699066,0,FALSE +"H520","Pearson.est","acetylcholine receptor antagonist",-0.76136,-1.96,0.00832,1308,0.12,"dicycloverine, iododexetimide, methscopolamine",2.07987667370928,0.920818753952375,TRUE +"H520","Pearson.est","adenosine receptor antagonist",-0.34721,-0.882,0.552,1422,0.951,"istradefylline",0.258060922270801,0.0218194830625861,FALSE +"H520","Pearson.est","adrenergic receptor agonist",-0.3918,-0.993,0.451,1253,1,"methyldopa, ritodrine, norepinephrine, isoetharine",0.345823458122039,0,FALSE +"H520","Pearson.est","adrenergic receptor antagonist",0.31608,0.82,0.682,207,0.878,"practolol, idazoxan, vincamine, propranolol",0.166215625343521,0.0565054840938974,FALSE +"H520","Pearson.est","AKT inhibitor",0.36932,0.966,0.498,516,0.885,"triciribine, MK.2206, ONC201, palomid.529, AT7867, GSK2110183",0.302770657240282,0.0530567293021746,FALSE +"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.25973,-0.665,0.858,1307,1,"CEP.37440, DMH1",0.0665127121512946,0,FALSE +"H520","Pearson.est","androgen receptor antagonist",-0.74075,-1.86,0.0217,1080,0.18,"bicalutamide, nilutamide, flutamide, enzalutamide, cyproterone.acetate",1.66354026615147,0.744727494896694,TRUE +"H520","Pearson.est","antioxidant",-0.61441,-1.6,0.0496,1141,0.428,"benfotiamine, trolox",1.3045183235098,0.368556230986828,FALSE +"H520","Pearson.est","AP inhibitor",0.68708,1.75,0.026,52,0.854,"birinapant, GDC.0152",1.58502665202918,0.068542129310995,FALSE +"H520","Pearson.est","ATPase inhibitor",0.41974,1.06,0.379,401,0.989,"k.strophanthidin, oligomycin.a, evodiamine, blebbistatin...., ouabain, thonzonium, NMS.873",0.421360790031928,0.0048037084028206,FALSE +"H520","Pearson.est","Aurora kinase inhibitor",0.31032,0.782,0.716,508,0.801,"MK.5108, barasertib.HQPA, barasertib, MK.8745, ENMD.2076, alisertib, PF.03814735, ZM.447439, CCT137690, MLN.8054, hesperadin, SNS.314",0.145086977692144,0.0963674839157623,FALSE +"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34519,-0.881,0.594,1322,0.92,"azalomycin.b, dirithromycin",0.226213555018806,0.0362121726544447,FALSE +"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.36667,0.918,0.524,340,0.902,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.280668713016273,0.0447934624580583,FALSE +"H520","Pearson.est","BCL inhibitor",0.38335,0.989,0.472,306,0.877,"oridonin, TW.37, HA14.1, obatoclax, venetoclax",0.326058001365912,0.0570004066339595,FALSE +"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.42427,1.13,0.314,149,1,"dasatinib, metatinib, bafetinib",0.503070351926785,0,FALSE +"H520","Pearson.est","benzodiazepine receptor agonist",0.41145,1.07,0.33,136,1,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.481486060122112,0,FALSE +"H520","Pearson.est","bromodomain inhibitor",-0.51138,-1.34,0.156,1242,0.669,"PFI.1, I.BET151",0.806875401645538,0.174573882232177,FALSE +"H520","Pearson.est","calcium channel blocker",-0.38234,-0.966,0.487,1120,0.995,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.312471038785366,0.00217691925427455,FALSE +"H520","Pearson.est","CC chemokine receptor antagonist",-0.24983,-0.654,0.875,360,0.974,"UNBS.5162, ZK811752, MK.0812, RS.504393, navarixin, SB.225002, PF.04136309",0.0579919469776868,0.0114410431213845,FALSE +"H520","Pearson.est","CDK inhibitor",-0.20338,-0.532,0.967,954,0.963,"arcyriaflavin.a, abemaciclib, AZD5438, R547, indirubin, ribociclib, JNJ.7706621, BMS.265246, TG.02",0.0145735259169983,0.0163737128754655,FALSE +"H520","Pearson.est","CHK inhibitor",-0.21786,-0.551,0.967,1327,0.974,"SB.218078",0.0145735259169983,0.0114410431213845,FALSE +"H520","Pearson.est","cyclooxygenase inhibitor",-0.40428,-1.05,0.385,1274,0.928,"AM.404, tryptanthrin, FR.122047, piroxicam, naproxen",0.414539270491499,0.0324520237811379,FALSE +"H520","Pearson.est","cytochrome P450 inhibitor",0.57695,1.49,0.0812,183,0.559,"PF.4981517, morin, eplerenone",1.09044397075882,0.252588192113577,FALSE +"H520","Pearson.est","DNA alkylating agent",-0.27267,-0.692,0.842,984,0.999,"mitomycin.c, carmustine, streptozotocin, melphalan, cyclophosphamide, satraplatin, temozolomide",0.0746879085003505,0.000434511774017692,FALSE +"H520","Pearson.est","DNA inhibitor",-0.24891,-0.637,0.895,1084,0.969,"melphalan, metronidazole, busulfan, pibenzimol, nithiamide",0.048176964684088,0.0136762229492347,FALSE +"H520","Pearson.est","DNA methyltransferase inhibitor",0.66149,1.69,0.0296,451,0.418,"decitabine, azacitidine, SGI.1027, fdcyd",1.52870828894106,0.378823718224965,FALSE +"H520","Pearson.est","DNA polymerase inhibitor",0.33928,0.86,0.602,289,0.904,"foscarnet, cephalomannine, cidofovir, idoxuridine",0.220403508742175,0.0438315695246367,FALSE +"H520","Pearson.est","DNA synthesis inhibitor",-0.27852,-0.721,0.775,952,1,"azodicarbonamide, anisomycin, mitomycin.c, CB.10.277, artesunate, altretamine, enocitabine",0.11069829749369,0,FALSE +"H520","Pearson.est","dopamine receptor antagonist",-0.41706,-1.08,0.354,1177,0.908,"mesoridazine, ziprasidone, paliperidone, remoxipride, lurasidone, amisulpride",0.450996737974212,0.0419141514789149,FALSE +"H520","Pearson.est","estrogen receptor agonist",-0.36956,-0.976,0.466,1275,1,"estrone, erteberel",0.33161408331,0,FALSE +"H520","Pearson.est","estrogen receptor antagonist",-0.82569,-2.1,0,1244,0.0746,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.12726117252733,TRUE +"H520","Pearson.est","FGFR inhibitor",-0.3032,-0.79,0.705,436,0.978,"orantinib, AZD4547, erdafitinib, regorafenib, dovitinib, PD.173074, nintedanib, MK.2461, lenvatinib, lucitanib",0.151810883008601,0.00966114521239857,FALSE +"H520","Pearson.est","FLT3 inhibitor",-0.3603,-0.924,0.535,1228,0.968,"TG.101348, pacritinib, quizartinib, TG.02, sunitinib, lestaurtinib",0.271646217978772,0.0141246426916063,FALSE +"H520","Pearson.est","glucocorticoid receptor agonist",-0.45101,-1.16,0.275,1026,0.934,"flumethasone, halcinonide, triamcinolone, desonide, triamcinolone.acetonide, prednisolone, beclomethasone.dipropionate, prednisolone.acetate, rimexolone, fluticasone.propionate, fluocinolone.acetonide, piretanide, flumethasone.pivalate, dexamethasone.acetate, hydrocortisone",0.560667306169737,0.0296531237699066,FALSE +"H520","Pearson.est","glutamate receptor antagonist",0.30263,0.791,0.697,236,0.839,"ACDPP, kynurenic.acid, tiletamine",0.156767221901991,0.0762380391712997,FALSE +"H520","Pearson.est","glycogen synthase kinase inhibitor",0.35796,0.951,0.487,48,0.874,"CHIR.99021",0.312471038785366,0.058488567365597,FALSE +"H520","Pearson.est","growth factor receptor inhibitor",-0.55484,-1.4,0.131,1356,0.671,"GW.441756, lestaurtinib",0.882728704344236,0.173277479831008,FALSE +"H520","Pearson.est","HCV inhibitor",0.32196,0.84,0.639,60,0.872,"daclatasvir",0.1944991418416,0.0594835150674328,FALSE +"H520","Pearson.est","HDAC inhibitor",0.48026,1.24,0.228,324,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, SB.939, ACY.1215, scriptaid, entinostat, resminostat, M.344, romidepsin",0.642065152999546,0,FALSE +"H520","Pearson.est","histamine receptor antagonist",-0.25225,-0.655,0.87,923,0.997,"nizatidine, lafutidine, cyproheptadine, tiotidine, ICI.162846, terfenadine, ebastine, ranitidine, BF2.649, epinastine",0.0604807473813815,0.00130484168834428,FALSE +"H520","Pearson.est","HMGCR inhibitor",0.3774,0.993,0.431,198,0.97,"atorvastatin, simvastatin",0.365522729839268,0.0132282657337552,FALSE +"H520","Pearson.est","HSP inhibitor",0.57377,1.51,0.0998,184,0.617,"BIIB021, NMS.E973, PU.H71, SNX.2112, NVP.AUY922, SNX.5422, ganetespib",1.00086945871263,0.209714835966758,FALSE +"H520","Pearson.est","JAK inhibitor",-0.45606,-1.16,0.282,1228,0.934,"TG.101348, pacritinib, CEP.33779, AZD1480, filgotinib, TG.02, lestaurtinib",0.549750891680639,0.0296531237699066,FALSE +"H520","Pearson.est","KIT inhibitor",0.28105,0.735,0.749,88,0.816,"midostaurin, dasatinib, OSI.930",0.125518182300534,0.0883098412461389,FALSE +"H520","Pearson.est","MDM inhibitor",-0.44364,-1.15,0.32,1104,0.897,"nutlin.3, CGM097, RITA",0.494850021680094,0.0472075569559079,FALSE +"H520","Pearson.est","MEK inhibitor",-0.21787,-0.565,0.936,1074,0.987,"refametinib, PD.318088, nobiletin, MEK162, BIX.02188, arctigenin",0.0287241512618947,0.00568284733036327,FALSE +"H520","Pearson.est","MET inhibitor",-0.5436,-1.39,0.149,1061,0.623,"INC.280, PHA.665752, NVP.BVU972, AMG458",0.826813731587726,0.20551195334083,FALSE +"H520","Pearson.est","microtubule inhibitor",0.34835,0.896,0.562,209,0.908,"estramustine.phosphate, triclabendazole",0.250263684430939,0.0419141514789149,FALSE +"H520","Pearson.est","mTOR inhibitor",0.67774,1.73,0.0193,227,0.48,"deforolimus, PI.103, everolimus, temsirolimus, AZD8055, NVP.BEZ235, PKI.179, torin.1, MLN0128, LY3023414, AZD2014, GDC.0980, PP242, torin.2, sirolimus, SB.2343",1.71444269099223,0.318758762624413,FALSE +"H520","Pearson.est","NFkB pathway inhibitor",-0.36892,-0.951,0.481,1075,0.988,"Ro.106.9920, IKK.2.inhibitor.V, tyloxapol, bindarit, parthenolide, betulinic.acid",0.317854923626168,0.00524305541237188,FALSE +"H520","Pearson.est","opioid receptor agonist",-0.46935,-1.21,0.259,1265,0.938,"ADL5859, salvinorin.a",0.586700235918748,0.0277971616209356,FALSE +"H520","Pearson.est","p38 MAPK inhibitor",-0.27164,-0.699,0.8,1344,1,"skepinone.l",0.0969100130080564,0,FALSE +"H520","Pearson.est","PARP inhibitor",-0.5499,-1.46,0.0782,839,0.682,"PJ.34, olaparib, E7449, AZD2461, niraparib, AG.14361, talazoparib",1.10679324694015,0.166215625343521,FALSE +"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.2951,-0.779,0.721,1038,0.968,"crenolanib, imatinib, KI.8751, axitinib, lenvatinib, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.142064735280571,0.0141246426916063,FALSE +"H520","Pearson.est","phosphatase inhibitor",-0.31777,-0.805,0.717,1203,0.979,"CID.5458317, menadione, alexidine",0.1444808443322,0.00921730819686218,FALSE +"H520","Pearson.est","phosphodiesterase inhibitor",0.31336,0.807,0.707,261,0.84,"papaverine, enoximone, EMD.53998",0.150580586203101,0.0757207139381184,FALSE +"H520","Pearson.est","PI3K inhibitor",0.3974,1.03,0.414,230,1,"PI.103, NVP.BEZ235, PKI.179, LY3023414, BGT226, GDC.0980, SB.2343, ZSTK.474",0.382999658879101,0,FALSE +"H520","Pearson.est","PLK inhibitor",0.33727,0.841,0.62,962,0.904,"HMN.214, BI.2536, volasertib, GSK461364, rigosertib, GW.843682X, NMS.1286937",0.207608310501746,0.0438315695246367,FALSE +"H520","Pearson.est","potassium channel blocker",0.62432,1.65,0.0584,423,0.384,"ML133, ibutilide, mepivacaine, dofetilide, oleoylethanolamide",1.2335871528876,0.415668775632469,FALSE +"H520","Pearson.est","PPAR receptor agonist",-0.36332,-0.944,0.476,1419,0.963,"fenofibrate",0.322393047279507,0.0163737128754655,FALSE +"H520","Pearson.est","progesterone receptor agonist",-0.7201,-1.83,0.0141,1161,0.135,"norgestrel, nomegestrol.acetate, danazol, dienogest, melengestrol.acetate, norethindrone.acetate",1.85078088734462,0.869666231504994,TRUE +"H520","Pearson.est","proteasome inhibitor",0.44222,1.14,0.313,416,1,"ONX.0914, MG.132, carfilzomib, delanzomib",0.504455662453552,0,FALSE +"H520","Pearson.est","protein synthesis inhibitor",0.30016,0.783,0.699,253,0.824,"clofoctol, cycloheximide, puromycin, brefeldin.a, thiostrepton",0.155522824254319,0.0840727883028842,FALSE +"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.34542,-0.895,0.583,1376,0.995,"CP.724714, rheochrysidin",0.234331445240986,0.00217691925427455,FALSE +"H520","Pearson.est","RAF inhibitor",0.47834,1.23,0.232,336,0.945,"SB.590885, vemurafenib, sorafenib, LGX818, dabrafenib, AZ.628",0.6345120151091,0.0245681914907371,FALSE +"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.3001,-0.765,0.734,1355,0.964,"sunitinib",0.134303940083929,0.0159229660971692,FALSE +"H520","Pearson.est","retinoid receptor agonist",0.42832,1.1,0.337,27,1,"LE.135",0.472370099128661,0,FALSE +"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.43338,-1.09,0.35,1441,0.937,"pentostatin",0.455931955649724,0.0282604091122217,FALSE +"H520","Pearson.est","serotonin receptor agonist",-0.70693,-1.83,0.0154,1246,0.135,"NAN.190, zolmitriptan, ipsapirone, aripiprazole",1.81247927916354,0.869666231504994,TRUE +"H520","Pearson.est","serotonin receptor antagonist",-0.42174,-1.1,0.359,1390,0.967,"lurasidone, aripiprazole",0.444905551421681,0.0145735259169983,FALSE +"H520","Pearson.est","sodium channel blocker",0.33502,0.868,0.617,453,0.925,"brivaracetam, ajmaline, mepivacaine, butamben, cibenzoline, mexiletine",0.209714835966758,0.0338582672609674,FALSE +"H520","Pearson.est","src inhibitor",-0.31848,-0.813,0.688,1036,0.994,"bosutinib, PP.1, PP.2, masitinib",0.162411561764489,0.00261361560268669,FALSE +"H520","Pearson.est","sterol demethylase inhibitor",-0.33923,-0.89,0.557,1163,0.969,"sulconazole, posaconazole, ketoconazole",0.254144804826271,0.0136762229492347,FALSE +"H520","Pearson.est","TGF beta receptor inhibitor",-0.5623,-1.45,0.105,931,0.621,"repsox, adaprev, SB.431542, D.4476, SB.525334",0.978810700930062,0.20690839982342,FALSE +"H520","Pearson.est","thymidylate synthase inhibitor",-0.33218,-0.874,0.593,479,0.904,"ftorafur, doxifluridine, raltitrexed, carmofur, capecitabine, trifluridine",0.226945306635737,0.0438315695246367,FALSE +"H520","Pearson.est","topoisomerase inhibitor",0.31477,0.816,0.668,564,0.853,"mitoxantrone, doxorubicin, idarubicin, exatecan.mesylate, amsacrine, rubitecan, epirubicin, etoposide, voreloxin, daunorubicin, teniposide, camptothecin, valrubicin, genz.644282, licochalcone.a",0.175223537524454,0.069050968832477,FALSE +"H520","Pearson.est","tubulin polymerization inhibitor",0.29879,0.773,0.705,393,0.789,"mebendazole, epothilone.b, oxibendazole, BNC105, CYT.997, vinorelbine, fenbendazole, verubulin, taltobulin, indibulin",0.151810883008601,0.10292299679058,FALSE +"H520","Pearson.est","tyrosine kinase inhibitor",0.25607,0.669,0.848,510,0.875,"dasatinib, AV.412, bafetinib, NVP.TAE226, sorafenib, mubritinib, tyrphostin.A9, vandetanib, tivantinib, apatinib, PP.121, regorafenib, hypericin",0.0716041477432862,0.0579919469776868,FALSE +"H520","Pearson.est","VEGFR inhibitor",0.19396,0.516,0.975,118,0.972,"BMS.690514, XL.647, OSI.930, SAR131675",0.0109953843014632,0.0123337350737254,FALSE +"H520","Pearson.est","vitamin D receptor agonist",0.5113,1.31,0.173,338,0.939,"ercalcitriol, calcitriol, maxacalcitol",0.761953896871205,0.0273344077338891,FALSE +"HCC15","Pearson.est","EGFR inhibitor",0.4747,1.21,0.243,371,0.981,"CUDC.101, ARRY.334543, BMS.690514, tyrphostin.AG.1478, erlotinib, XL.647, canertinib, WZ.3146, brigatinib, AST.1306, BIBU.1361, gefitinib, PD.168393, icotinib, lapatinib, afatinib, osimertinib, rociletinib, pelitinib, BIBX.1382, AZD8931",0.614393726401688,0.0083309926200515,FALSE +"HCC15","Pearson.est","Abl kinase inhibitor",0.36733,0.926,0.519,185,0.874,"dasatinib, metatinib, bafetinib",0.284832642151542,0.058488567365597,FALSE +"HCC15","Pearson.est","acetylcholine receptor agonist",0.27619,0.706,0.796,498,0.873,"xanomeline, oxiracetam, tremorine",0.0990869322623309,0.0589857562944303,FALSE +"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.75094,-1.99,0.00233,1279,0.118,"dicycloverine, methscopolamine, iododexetimide",2.63264407897398,0.928117992693875,TRUE +"HCC15","Pearson.est","adenosine receptor antagonist",0.4539,1.16,0.271,111,0.966,"theophylline, PSB.1115",0.567030709125594,0.0150228735845067,FALSE +"HCC15","Pearson.est","adrenergic receptor agonist",-0.37441,-0.992,0.426,1230,0.943,"ritodrine, methyldopa, norepinephrine, isoetharine",0.370590400897281,0.0254883072626717,FALSE +"HCC15","Pearson.est","adrenergic receptor antagonist",0.36834,0.93,0.531,170,0.9,"practolol, idazoxan, propranolol, vincamine",0.274905478918531,0.0457574905606751,FALSE +"HCC15","Pearson.est","AKT inhibitor",0.38861,0.992,0.446,446,0.956,"MK.2206, triciribine, palomid.529, AT7867, ONC201",0.350665141287858,0.0195421077238999,FALSE +"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.24648,-0.634,0.881,1193,0.966,"alectinib, CEP.37440, DMH1",0.0550240915879521,0.0150228735845067,FALSE +"HCC15","Pearson.est","androgen receptor antagonist",-0.72362,-1.96,0.0121,1184,0.0767,"flutamide, nilutamide, enzalutamide, cyproterone.acetate",1.91721462968355,1.11520463605102,TRUE +"HCC15","Pearson.est","antioxidant",-0.57035,-1.49,0.0938,1132,0.466,"benfotiamine, trolox",1.02779716162094,0.33161408331,FALSE +"HCC15","Pearson.est","AP inhibitor",0.62917,1.57,0.0485,82,0.617,"birinapant, GDC.0152",1.31425826139774,0.209714835966758,FALSE +"HCC15","Pearson.est","ATPase inhibitor",0.39911,1.02,0.417,279,0.935,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin....",0.379863945026242,0.0291883891274822,FALSE +"HCC15","Pearson.est","Aurora kinase inhibitor",0.40262,1.03,0.41,421,0.959,"alisertib, MK.8745, MK.5108, barasertib.HQPA, ENMD.2076, barasertib, ZM.447439, PF.03814735, danusertib, CCT137690, SNS.314",0.387216143280265,0.0181813928293364,FALSE +"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.30022,0.744,0.777,161,0.912,"tedizolid, azithromycin",0.109578981199086,0.0400051616715838,FALSE +"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.32057,0.81,0.665,434,0.884,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.177178354696895,0.0535477349869269,FALSE +"HCC15","Pearson.est","BCL inhibitor",-0.35061,-0.95,0.468,1382,0.856,"gossypol, ABT.737",0.329754146925876,0.0675262353228468,FALSE +"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",0.41978,1.07,0.346,185,1,"dasatinib, metatinib, bafetinib",0.460923901207223,0,FALSE +"HCC15","Pearson.est","benzodiazepine receptor agonist",0.41034,1.04,0.377,146,1,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.423658649794207,0,FALSE +"HCC15","Pearson.est","bromodomain inhibitor",-0.382,-0.998,0.461,1149,1,"I.BET151, PFI.1",0.336299074610352,0,FALSE +"HCC15","Pearson.est","calcium channel blocker",-0.3376,-0.897,0.536,1244,0.896,"efonidipine.monoethanolate, SR.33805, mibefradil",0.27083521030723,0.0476919903378748,FALSE +"HCC15","Pearson.est","CC chemokine receptor antagonist",0.31191,0.812,0.701,470,0.908,"UNBS.5162, MK.0812, ZK811752, RS.504393",0.154281982033341,0.0419141514789149,FALSE +"HCC15","Pearson.est","CDK inhibitor",0.18167,0.459,0.995,475,0.989,"alvocidib, NU6027, kenpaullone, P276.00, AT.7519, aminopurvalanol.a, CR8..R., dinaciclib",0.00217691925427455,0.0048037084028206,FALSE +"HCC15","Pearson.est","CHK inhibitor",-0.41944,-1.1,0.32,1169,0.983,"AZD7762, SCH.900776, SB.218078",0.494850021680094,0.00744648216786438,FALSE +"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.36877,-0.976,0.453,1212,0.928,"acetylsalicylsalicylic.acid, FR.122047, piroxicam, AM.404, tryptanthrin, naproxen",0.343901797987168,0.0324520237811379,FALSE +"HCC15","Pearson.est","cytochrome P450 inhibitor",0.55354,1.39,0.117,243,0.803,"PF.4981517, morin, eplerenone",0.931814138253838,0.095284454721319,FALSE +"HCC15","Pearson.est","DNA alkylating agent",-0.25436,-0.679,0.845,1150,0.938,"streptozotocin, satraplatin, cyclophosphamide, temozolomide",0.0731432910503077,0.0277971616209356,FALSE +"HCC15","Pearson.est","DNA inhibitor",-0.23693,-0.627,0.891,1344,0.948,"pibenzimol, nithiamide",0.0501222959631252,0.0231916626619338,FALSE +"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.69931,1.76,0.017,357,0.742,"azacitidine, SGI.1027, decitabine, fdcyd",1.76955107862173,0.129596094720973,FALSE +"HCC15","Pearson.est","DNA polymerase inhibitor",0.46272,1.16,0.282,212,0.966,"foscarnet, cephalomannine, idoxuridine, cidofovir",0.549750891680639,0.0150228735845067,FALSE +"HCC15","Pearson.est","DNA synthesis inhibitor",-0.35604,-0.929,0.5,1415,0.864,"altretamine, enocitabine",0.301029995663981,0.0634862575211067,FALSE +"HCC15","Pearson.est","dopamine receptor antagonist",-0.3643,-0.959,0.486,1029,0.877,"nemonapride, clebopride, mesoridazine, ziprasidone, paliperidone, remoxipride, amisulpride, lurasidone",0.313363730737707,0.0570004066339595,FALSE +"HCC15","Pearson.est","estrogen receptor agonist",-0.29956,-0.801,0.704,1268,0.889,"estrone, erteberel",0.152427340857888,0.0510982390297863,FALSE +"HCC15","Pearson.est","estrogen receptor antagonist",-0.79436,-2.06,0.00483,1292,0.13,"danazol, raloxifene, fulvestrant, tamoxifen",2.31605286924849,0.886056647693163,TRUE +"HCC15","Pearson.est","FGFR inhibitor",-0.31224,-0.832,0.636,449,0.925,"orantinib, regorafenib, erdafitinib, AZD4547, PD.173074, dovitinib, nintedanib, MK.2461, lucitanib, lenvatinib",0.196542884351586,0.0338582672609674,FALSE +"HCC15","Pearson.est","FLT3 inhibitor",-0.31852,-0.846,0.62,1151,0.932,"KW.2449, pacritinib, TG.101348, quizartinib, TG.02, lestaurtinib, sunitinib",0.207608310501746,0.0305840876460186,FALSE +"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.40605,-1.06,0.368,1017,1,"flumethasone, halcinonide, triamcinolone, desonide, rimexolone, prednisolone, triamcinolone.acetonide, prednisolone.acetate, beclomethasone.dipropionate, fluticasone.propionate, fluocinolone.acetonide, piretanide, dexamethasone.acetate, flumethasone.pivalate, hydrocortisone",0.434152181326482,0,FALSE +"HCC15","Pearson.est","glutamate receptor antagonist",0.31265,0.789,0.703,256,0.867,"ACDPP, tiletamine, kynurenic.acid",0.153044674980176,0.0619809025237897,FALSE +"HCC15","Pearson.est","glycogen synthase kinase inhibitor",0.38542,0.975,0.478,23,0.951,"CHIR.99021",0.320572103387881,0.0218194830625861,FALSE +"HCC15","Pearson.est","growth factor receptor inhibitor",-0.50199,-1.32,0.18,1353,0.737,"GW.441756, lestaurtinib",0.744727494896694,0.132532512140949,FALSE +"HCC15","Pearson.est","HCV inhibitor",0.35214,0.905,0.568,64,0.884,"daclatasvir",0.245651664288981,0.0535477349869269,FALSE +"HCC15","Pearson.est","HDAC inhibitor",0.51723,1.31,0.164,448,0.852,"chidamide, nexturastat.a, panobinostat, belinostat, SB.939, NSC.3852, scriptaid, entinostat, M.344, ACY.1215, resminostat, givinostat, trichostatin.a, mocetinostat, dacinostat, romidepsin",0.785156151952302,0.0695604052332999,FALSE +"HCC15","Pearson.est","histamine receptor antagonist",-0.20707,-0.558,0.945,963,0.977,"lafutidine, ICI.162846, tiotidine, cyproheptadine, terfenadine, ebastine, ranitidine, BF2.649, epinastine",0.0245681914907371,0.0101054362812269,FALSE +"HCC15","Pearson.est","HMGCR inhibitor",0.37717,0.944,0.519,211,0.941,"atorvastatin, simvastatin",0.284832642151542,0.0264103765727431,FALSE +"HCC15","Pearson.est","HSP inhibitor",0.59866,1.51,0.0688,195,0.665,"BIIB021, NMS.E973, PU.H71, SNX.2112, NVP.AUY922, SNX.5422, ganetespib",1.16241156176449,0.177178354696895,FALSE +"HCC15","Pearson.est","JAK inhibitor",-0.33546,-0.872,0.577,1165,0.914,"pacritinib, TG.101348, CEP.33779, AZD1480, filgotinib, TG.02, lestaurtinib",0.238824186844269,0.0390538042661686,FALSE +"HCC15","Pearson.est","KIT inhibitor",0.28591,0.72,0.825,104,0.878,"midostaurin, OSI.930, dasatinib",0.0835460514500749,0.0565054840938974,FALSE +"HCC15","Pearson.est","MDM inhibitor",-0.28225,-0.76,0.708,407,0.873,"serdemetan, AMG.232, idasanutlin, nutlin.3, CGM097, RITA",0.149966742310231,0.0589857562944303,FALSE +"HCC15","Pearson.est","MEK inhibitor",-0.26987,-0.721,0.764,1114,0.906,"PD.318088, nobiletin, refametinib, MEK162, BIX.02188, arctigenin",0.11690664142431,0.0428718023231869,FALSE +"HCC15","Pearson.est","MET inhibitor",-0.57646,-1.55,0.0798,1135,0.497,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.09799710864927,0.303643611266668,FALSE +"HCC15","Pearson.est","microtubule inhibitor",0.40806,1.03,0.42,519,0.959,"estramustine.phosphate, triclabendazole, D.64131, cabazitaxel, podophyllotoxin",0.3767507096021,0.0181813928293364,FALSE +"HCC15","Pearson.est","mTOR inhibitor",0.64849,1.62,0.0462,393,0.949,"deforolimus, PI.103, AZD8055, everolimus, PKI.179, NVP.BEZ235, temsirolimus, LY3023414, torin.1, torin.2, MLN0128, AZD2014, PP242, GDC.0980, WYE.125132, sirolimus, palomid.529, voxtalisib, PF.04691502, SB.2343",1.33535802444387,0.0227337875727074,FALSE +"HCC15","Pearson.est","NFkB pathway inhibitor",-0.37119,-0.972,0.453,1046,0.891,"IKK.2.inhibitor.V, curcumin, tyloxapol, Ro.106.9920, bindarit, parthenolide, betulinic.acid",0.343901797987168,0.0501222959631252,FALSE +"HCC15","Pearson.est","opioid receptor agonist",-0.40723,-1.1,0.328,1285,0.983,"ADL5859, salvinorin.a",0.484126156288321,0.00744648216786438,FALSE +"HCC15","Pearson.est","p38 MAPK inhibitor",-0.188,-0.508,0.983,898,0.978,"SB.242235, talmapimod, CMPD.1, TAK.715, skepinone.l",0.00744648216786438,0.00966114521239857,FALSE +"HCC15","Pearson.est","PARP inhibitor",-0.57564,-1.52,0.0745,987,0.476,"olaparib, niraparib, AZD2461, AG.14361, talazoparib",1.12784372725171,0.322393047279507,FALSE +"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.29684,-0.792,0.7,1118,0.874,"imatinib, axitinib, lenvatinib, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.154901959985743,0.058488567365597,FALSE +"HCC15","Pearson.est","phosphatase inhibitor",-0.29889,-0.785,0.718,1166,0.86,"CID.5458317, menadione, alexidine",0.1438755557577,0.0655015487564323,FALSE +"HCC15","Pearson.est","phosphodiesterase inhibitor",0.28622,0.726,0.808,290,0.892,"papaverine, enoximone, EMD.53998",0.0925886392254138,0.0496351456238769,FALSE +"HCC15","Pearson.est","PI3K inhibitor",0.35301,0.881,0.597,393,0.87,"PI.103, PKI.179, NVP.BEZ235, BGT226, LY3023414, GDC.0980, buparlisib, ZSTK.474, voxtalisib, PF.04691502, SB.2343",0.224025668870631,0.0604807473813815,FALSE +"HCC15","Pearson.est","PLK inhibitor",0.52789,1.33,0.158,557,0.891,"HMN.214, BI.2536, volasertib",0.801342913045577,0.0501222959631252,FALSE +"HCC15","Pearson.est","potassium channel blocker",0.64186,1.6,0.0488,370,0.706,"ML133, ibutilide, mepivacaine, oleoylethanolamide, dofetilide",1.31158017799729,0.151195298948196,FALSE +"HCC15","Pearson.est","PPAR receptor agonist",-0.38262,-1.01,0.432,1134,1,"S26948, clofibrate, fenofibrate",0.364516253185088,0,FALSE +"HCC15","Pearson.est","progesterone receptor agonist",-0.74274,-1.98,0.00495,1220,0.0861,"melengestrol.acetate, dienogest, nomegestrol.acetate, norgestrel, danazol, norethindrone.acetate",2.30539480106643,1.06499684854635,TRUE +"HCC15","Pearson.est","proteasome inhibitor",0.43655,1.1,0.326,455,1,"ONX.0914, MG.132, carfilzomib, delanzomib",0.486782399932061,0,FALSE +"HCC15","Pearson.est","protein synthesis inhibitor",0.23232,0.601,0.919,268,0.965,"clofoctol, cycloheximide, puromycin, thiostrepton",0.0366844886138887,0.0154726866562074,FALSE +"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.33983,0.854,0.624,341,0.889,"AV.412, NVP.TAE226, mubritinib, tyrphostin.A9",0.204815410317576,0.0510982390297863,FALSE +"HCC15","Pearson.est","RAF inhibitor",0.48008,1.21,0.264,364,0.981,"SB.590885, vemurafenib, sorafenib, LGX818, dabrafenib, AZ.628",0.578396073130169,0.0083309926200515,FALSE +"HCC15","Pearson.est","RET tyrosine kinase inhibitor",-0.30204,-0.811,0.676,1393,0.933,"sunitinib",0.170053304058364,0.0301183562535,FALSE +"HCC15","Pearson.est","retinoid receptor agonist",0.29303,0.735,0.79,67,0.902,"LE.135",0.102372908709559,0.0447934624580583,FALSE +"HCC15","Pearson.est","ribonucleotide reductase inhibitor",-0.36771,-0.992,0.4,1441,0.943,"pentostatin",0.397940008672038,0.0254883072626717,FALSE +"HCC15","Pearson.est","serotonin receptor agonist",-0.67185,-1.78,0.0221,1211,0.203,"NAN.190, zolmitriptan, ipsapirone, aripiprazole",1.65560772631489,0.692503962086787,TRUE +"HCC15","Pearson.est","serotonin receptor antagonist",-0.42442,-1.16,0.249,1390,0.981,"lurasidone, aripiprazole",0.603800652904264,0.0083309926200515,FALSE +"HCC15","Pearson.est","sodium channel blocker",0.34602,0.881,0.603,463,0.87,"brivaracetam, ajmaline, mepivacaine, butamben, mexiletine, cibenzoline",0.219682687859849,0.0604807473813815,FALSE +"HCC15","Pearson.est","src inhibitor",-0.31149,-0.81,0.714,1283,0.902,"PP.2, masitinib",0.146301788223826,0.0447934624580583,FALSE +"HCC15","Pearson.est","sterol demethylase inhibitor",0.37449,0.958,0.496,10,0.948,"chlormidazole",0.304518323509803,0.0231916626619338,FALSE +"HCC15","Pearson.est","TGF beta receptor inhibitor",-0.47619,-1.27,0.198,1048,0.772,"D.4476, SB.431542, adaprev, SB.525334",0.703334809738469,0.112382699664264,FALSE +"HCC15","Pearson.est","thymidylate synthase inhibitor",0.37034,0.938,0.518,733,0.917,"ftorafur, raltitrexed, doxifluridine, capecitabine, carmofur",0.285670240254767,0.0376306643299789,FALSE +"HCC15","Pearson.est","topoisomerase inhibitor",0.32297,0.813,0.703,524,0.934,"mitoxantrone, idarubicin, exatecan.mesylate, doxorubicin, amsacrine, rubitecan, voreloxin, etoposide, camptothecin, teniposide, daunorubicin, genz.644282, valrubicin",0.153044674980176,0.0296531237699066,FALSE +"HCC15","Pearson.est","tubulin polymerization inhibitor",0.41064,1.04,0.403,592,1,"epothilone.b, mebendazole, BNC105, oxibendazole, CYT.997, vinorelbine, fenbendazole, taltobulin, verubulin, indibulin, plinabulin, parbendazole, KX2.391, dolastatin.10, podophyllotoxin, combretastatin.A.4, paclitaxel, vindesine",0.39469495385889,0,FALSE +"HCC15","Pearson.est","tyrosine kinase inhibitor",0.31143,0.79,0.708,586,0.891,"dasatinib, AV.412, NVP.TAE226, bafetinib, mubritinib, sorafenib, tyrphostin.A9, tivantinib, aminopurvalanol.a, apatinib, vandetanib, regorafenib, hypericin, GTP.14564, PP.121, tyrphostin.AG.99",0.149966742310231,0.0501222959631252,FALSE +"HCC15","Pearson.est","VEGFR inhibitor",0.21315,0.54,0.952,129,0.984,"BMS.690514, OSI.930, XL.647, SAR131675",0.0213630516155257,0.00700490156865849,FALSE +"HCC15","Pearson.est","vitamin D receptor agonist",0.55408,1.45,0.089,590,0.726,"ercalcitriol, calcitriol, maxacalcitol, tacalcitol, doxercalciferol",1.05060999335509,0.139063379299906,FALSE +"H460","Pearson.est","EGFR inhibitor",0.3822,0.992,0.443,362,0.889,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, BMS.690514, erlotinib, WZ.3146, XL.647, canertinib, brigatinib, gefitinib, AST.1306, PD.168393, BIBU.1361, icotinib, BIBX.1382, afatinib, pelitinib, lapatinib, AZD8931",0.35359627377693,0.0510982390297863,FALSE +"H460","Pearson.est","Abl kinase inhibitor",0.27114,0.713,0.786,199,0.938,"dasatinib, metatinib, bafetinib",0.104577453960592,0.0277971616209356,FALSE +"H460","Pearson.est","acetylcholine receptor agonist",-0.24119,-0.625,0.898,1140,0.976,"pilocarpine, nicotine",0.0467236633326956,0.0105501823333082,FALSE +"H460","Pearson.est","acetylcholine receptor antagonist",-0.74252,-1.93,0.00575,1329,0.105,"dicycloverine, iododexetimide, methscopolamine",2.24033215531037,0.978810700930062,TRUE +"H460","Pearson.est","adenosine receptor antagonist",-0.38,-0.969,0.455,1218,0.888,"sulmazole, istradefylline",0.341988603342888,0.051587034221399,FALSE +"H460","Pearson.est","adrenergic receptor agonist",-0.40242,-1.03,0.414,1041,1,"midodrine, xylazine, oxymetazoline, ritodrine, methyldopa, norepinephrine, isoetharine",0.382999658879101,0,FALSE +"H460","Pearson.est","adrenergic receptor antagonist",0.35206,0.91,0.554,165,0.877,"practolol, propranolol, idazoxan, vincamine",0.25649023527157,0.0570004066339595,FALSE +"H460","Pearson.est","AKT inhibitor",0.36416,0.961,0.484,493,0.858,"MK.2206, triciribine, ONC201, GSK2110183, palomid.529, AT7867",0.315154638355588,0.0665127121512946,FALSE +"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.38897,-1.01,0.426,1236,0.909,"alectinib, CEP.37440, DMH1",0.370590400897281,0.0414361167780325,FALSE +"H460","Pearson.est","androgen receptor antagonist",-0.71618,-1.89,0.00816,1044,0.111,"bicalutamide, nilutamide, flutamide, enzalutamide, cyproterone.acetate",2.08830984124614,0.954677021213343,TRUE +"H460","Pearson.est","antioxidant",-0.62435,-1.61,0.066,1170,0.373,"benfotiamine, trolox",1.18045606445813,0.428291168191312,FALSE +"H460","Pearson.est","AP inhibitor",0.64981,1.68,0.0414,62,0.656,"birinapant, GDC.0152",1.3829996588791,0.18309616062434,FALSE +"H460","Pearson.est","ATPase inhibitor",0.41178,1.1,0.321,411,1,"k.strophanthidin, oligomycin.a, ouabain, blebbistatin...., evodiamine, NMS.873, thonzonium",0.493494967595128,0,FALSE +"H460","Pearson.est","Aurora kinase inhibitor",0.23861,0.633,0.888,506,0.945,"MK.5108, barasertib, MK.8745, barasertib.HQPA, alisertib, MLN.8054, ENMD.2076, ZM.447439, PF.03814735, CCT137690",0.051587034221399,0.0245681914907371,FALSE +"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.40025,-1.04,0.393,1332,1,"azalomycin.b, dirithromycin",0.405607449624573,0,FALSE +"H460","Pearson.est","bacterial DNA gyrase inhibitor",0.4241,1.11,0.326,322,1,"lomefloxacin, finafloxacin, novobiocin, trovafloxacin",0.486782399932061,0,FALSE +"H460","Pearson.est","BCL inhibitor",-0.37063,-0.945,0.489,1401,0.844,"gossypol, ABT.737",0.31069114087638,0.073657553374345,FALSE +"H460","Pearson.est","Bcr.Abl kinase inhibitor",0.33168,0.887,0.557,199,0.845,"dasatinib, metatinib, bafetinib",0.254144804826271,0.0731432910503077,FALSE +"H460","Pearson.est","benzodiazepine receptor agonist",0.41886,1.11,0.337,108,1,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.472370099128661,0,FALSE +"H460","Pearson.est","bromodomain inhibitor",-0.58354,-1.52,0.0974,1038,0.394,"bromosporine, JQ1...., I.BET151, PFI.1",1.01144104312138,0.404503778174426,FALSE +"H460","Pearson.est","calcium channel blocker",-0.36745,-0.949,0.498,1201,0.866,"efonidipine.monoethanolate, SR.33805, mibefradil",0.302770657240282,0.0624821079826534,FALSE +"H460","Pearson.est","CC chemokine receptor antagonist",-0.26585,-0.683,0.838,1016,0.972,"navarixin, SB.225002, PF.04136309",0.0767559813697235,0.0123337350737254,FALSE +"H460","Pearson.est","CDK inhibitor",-0.33156,-0.827,0.654,1078,0.885,"indirubin, AZD5438, abemaciclib, R547, ribociclib, BMS.265246, TG.02, JNJ.7706621",0.184422251675733,0.0530567293021746,FALSE +"H460","Pearson.est","CHK inhibitor",-0.44864,-1.18,0.254,1034,1,"SCH.900776, AZD7762, SB.218078",0.595166283380062,0,FALSE +"H460","Pearson.est","cyclooxygenase inhibitor",-0.3727,-0.943,0.503,1183,0.794,"AM.404, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam, naproxen",0.298432014944073,0.100179497572904,FALSE +"H460","Pearson.est","cytochrome P450 inhibitor",0.57781,1.53,0.0799,252,0.676,"PF.4981517, morin, eplerenone",1.09745322068601,0.170053304058364,FALSE +"H460","Pearson.est","DNA alkylating agent",-0.34785,-0.897,0.554,990,0.783,"mitomycin.c, carmustine, streptozotocin, melphalan, TH.302, satraplatin, cyclophosphamide, temozolomide",0.25649023527157,0.106238237942057,FALSE +"H460","Pearson.est","DNA inhibitor",-0.24333,-0.615,0.895,1366,0.965,"nithiamide, pibenzimol",0.048176964684088,0.0154726866562074,FALSE +"H460","Pearson.est","DNA methyltransferase inhibitor",0.54914,1.41,0.101,554,0.717,"azacitidine, decitabine, SGI.1027, fdcyd",0.995678626217357,0.1444808443322,FALSE +"H460","Pearson.est","DNA polymerase inhibitor",0.35889,0.927,0.526,129,0.883,"foscarnet, cephalomannine, cidofovir",0.279014255846261,0.0540392964224314,FALSE +"H460","Pearson.est","DNA synthesis inhibitor",-0.18947,-0.482,0.983,1420,0.984,"enocitabine",0.00744648216786438,0.00700490156865849,FALSE +"H460","Pearson.est","dopamine receptor antagonist",-0.36938,-0.94,0.5,1120,0.775,"mesoridazine, ziprasidone, remoxipride, paliperidone, amisulpride, lurasidone",0.301029995663981,0.11069829749369,FALSE +"H460","Pearson.est","estrogen receptor agonist",-0.39754,-1.02,0.418,1088,1,"ethinyl.estradiol, estrone, erteberel",0.378823718224965,0,FALSE +"H460","Pearson.est","estrogen receptor antagonist",-0.83998,-2.19,0.00355,1259,0.0213,"danazol, raloxifene, fulvestrant, tamoxifen",2.44977164694491,1.67162039656126,TRUE +"H460","Pearson.est","FGFR inhibitor",-0.4142,-1.04,0.369,1048,1,"nintedanib, MK.2461, lenvatinib, lucitanib",0.43297363384094,0,FALSE +"H460","Pearson.est","FLT3 inhibitor",-0.40395,-1.02,0.417,1172,1,"quizartinib, TG.101348, KW.2449, pacritinib, TG.02, sunitinib, lestaurtinib",0.379863945026242,0,FALSE +"H460","Pearson.est","glucocorticoid receptor agonist",-0.39015,-0.986,0.448,867,0.923,"triamcinolone.acetonide, fluorometholone, desonide, clobetasol.propionate, halcinonide, halobetasol.propionate, fludroxycortide, triamcinolone, rimexolone, flumethasone, prednisolone.acetate, prednisolone, beclomethasone.dipropionate, fluocinolone.acetonide, fluticasone.propionate, piretanide, hydrocortisone, flumethasone.pivalate, dexamethasone.acetate",0.348721986001856,0.0347982989740879,FALSE +"H460","Pearson.est","glutamate receptor antagonist",0.31904,0.836,0.626,194,0.803,"ACDPP, kynurenic.acid, tiletamine",0.20342566678957,0.095284454721319,FALSE +"H460","Pearson.est","glycogen synthase kinase inhibitor",0.36918,0.965,0.49,42,0.898,"CHIR.99021",0.309803919971486,0.0467236633326956,FALSE +"H460","Pearson.est","growth factor receptor inhibitor",-0.67217,-1.73,0.025,1267,0.231,"GSK1838705A, GW.441756, lestaurtinib",1.60205999132796,0.636388020107856,TRUE +"H460","Pearson.est","HCV inhibitor",0.38326,1.02,0.418,61,1,"daclatasvir",0.378823718224965,0,FALSE +"H460","Pearson.est","HDAC inhibitor",0.45107,1.19,0.261,169,1,"nexturastat.a, chidamide, panobinostat, belinostat, NSC.3852, scriptaid, SB.939, ACY.1215",0.583359492661719,0,FALSE +"H460","Pearson.est","histamine receptor antagonist",-0.31335,-0.802,0.694,987,0.881,"lafutidine, cyproheptadine, ICI.162846, terfenadine, ranitidine, ebastine, tiotidine, epinastine, BF2.649",0.158640529545145,0.0550240915879521,FALSE +"H460","Pearson.est","HMGCR inhibitor",0.38329,1,0.445,206,0.988,"atorvastatin, simvastatin",0.351639989019068,0.00524305541237188,FALSE +"H460","Pearson.est","HSP inhibitor",0.46014,1.21,0.246,250,1,"BIIB021, NMS.E973, PU.H71, NVP.AUY922, ganetespib, SNX.2112, SNX.5422",0.609064892896621,0,FALSE +"H460","Pearson.est","JAK inhibitor",-0.39251,-1.03,0.397,1058,1,"AT.9283, CEP.33779, TG.101348, pacritinib, AZD1480, TG.02, filgotinib, lestaurtinib",0.401209493236885,0,FALSE +"H460","Pearson.est","KIT inhibitor",-0.29241,-0.739,0.774,1288,0.915,"vatalanib, telatinib, sunitinib, masitinib",0.111259039317107,0.0385789059335517,FALSE +"H460","Pearson.est","MDM inhibitor",0.24272,0.647,0.878,1098,0.959,"serdemetan, idasanutlin, AMG.232, nutlin.3, CGM097, RITA",0.0565054840938974,0.0181813928293364,FALSE +"H460","Pearson.est","MEK inhibitor",-0.20611,-0.538,0.966,1160,0.982,"MEK162, BIX.02188, nobiletin, arctigenin",0.0150228735845067,0.00788851221305034,FALSE +"H460","Pearson.est","MET inhibitor",-0.67956,-1.77,0.0186,1131,0.215,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.73048705578208,0.667561540084395,TRUE +"H460","Pearson.est","microtubule inhibitor",0.33814,0.901,0.556,212,0.855,"estramustine.phosphate, triclabendazole",0.254925208417942,0.0680338852718274,FALSE +"H460","Pearson.est","mTOR inhibitor",0.69986,1.86,0.0144,186,0.425,"deforolimus, PI.103, torin.1, AZD8055, PKI.179, everolimus, NVP.BEZ235, temsirolimus, PP242, MLN0128, LY3023414, AZD2014, sirolimus, SB.2343, GDC.0980, torin.2",1.84163750790475,0.371611069949688,FALSE +"H460","Pearson.est","NFkB pathway inhibitor",-0.37172,-0.977,0.427,949,0.905,"tyloxapol, curcumin, IKK.2.inhibitor.V, bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.369572124974976,0.0433514207947967,FALSE +"H460","Pearson.est","opioid receptor agonist",-0.45726,-1.17,0.285,1272,0.968,"ADL5859, salvinorin.a",0.54515513999149,0.0141246426916063,FALSE +"H460","Pearson.est","p38 MAPK inhibitor",-0.24733,-0.646,0.866,875,0.997,"talmapimod, SB.242235, TAK.715, skepinone.l",0.0624821079826534,0.00130484168834428,FALSE +"H460","Pearson.est","PARP inhibitor",-0.53099,-1.36,0.145,835,0.612,"E7449, PJ.34, niraparib, AZD2461, olaparib, AG.14361, talazoparib",0.838631997765025,0.213248577854439,FALSE +"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.38374,-0.943,0.496,968,0.794,"motesanib, ponatinib, crenolanib, nintedanib, imatinib, lenvatinib, KI.8751, axitinib, vatalanib, telatinib, sunitinib, CP.673451, masitinib",0.304518323509803,0.100179497572904,FALSE +"H460","Pearson.est","phosphatase inhibitor",-0.35984,-0.924,0.528,1234,0.78,"menadione, CID.5458317, alexidine",0.277366077466188,0.10790539730952,FALSE +"H460","Pearson.est","phosphodiesterase inhibitor",0.20192,0.535,0.969,298,0.963,"papaverine, enoximone, EMD.53998",0.0136762229492347,0.0163737128754655,FALSE +"H460","Pearson.est","PI3K inhibitor",0.397,1.05,0.394,479,1,"PI.103, PKI.179, NVP.BEZ235, BGT226, LY3023414, SB.2343, GDC.0980, ZSTK.474, voxtalisib, PF.04691502, PI3K.IN.2, PI.828, buparlisib, PF.05212384, YM.201636, CUDC.907",0.404503778174426,0,FALSE +"H460","Pearson.est","PLK inhibitor",-0.30306,-0.767,0.729,844,0.917,"rigosertib, volasertib, GSK461364, NMS.1286937, GW.843682X",0.137272471682025,0.0376306643299789,FALSE +"H460","Pearson.est","potassium channel blocker",0.58001,1.52,0.0714,459,0.562,"ML133, ibutilide, dofetilide, oleoylethanolamide, mepivacaine",1.14630178822383,0.250263684430939,FALSE +"H460","Pearson.est","PPAR receptor agonist",-0.32245,-0.817,0.649,1397,0.879,"fenofibrate",0.187755303199631,0.0560111249262281,FALSE +"H460","Pearson.est","progesterone receptor agonist",-0.61073,-1.55,0.0819,1133,0.384,"norgestrel, dienogest, danazol, melengestrol.acetate, nomegestrol.acetate, norethindrone.acetate",1.08671609823958,0.415668775632469,FALSE +"H460","Pearson.est","proteasome inhibitor",0.32894,0.844,0.601,205,0.853,"ONX.0914, MG.132",0.22112552799726,0.069050968832477,FALSE +"H460","Pearson.est","protein synthesis inhibitor",0.25803,0.691,0.843,448,0.936,"clofoctol, cycloheximide, brefeldin.a, azomycin..2.nitroimidazole., thiostrepton, methacycline, chloramphenicol.palmitate, puromycin",0.0741724253752577,0.0287241512618947,FALSE +"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.36757,-0.955,0.496,1371,0.885,"CP.724714, rheochrysidin",0.304518323509803,0.0530567293021746,FALSE +"H460","Pearson.est","RAF inhibitor",0.40459,1.03,0.378,401,1,"SB.590885, vemurafenib, LGX818, AZ.628, sorafenib, dabrafenib",0.422508200162775,0,FALSE +"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.39823,-1.01,0.445,1375,0.909,"sunitinib",0.351639989019068,0.0414361167780325,FALSE +"H460","Pearson.est","retinoid receptor agonist",0.38216,0.993,0.451,48,0.943,"LE.135",0.345823458122039,0.0254883072626717,FALSE +"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.3878,-1.01,0.423,1442,0.909,"pentostatin",0.373659632624958,0.0414361167780325,FALSE +"H460","Pearson.est","serotonin receptor agonist",-0.77289,-1.96,0.00391,1379,0.122,"ipsapirone, zolmitriptan, aripiprazole",2.40782324260413,0.913640169325252,TRUE +"H460","Pearson.est","serotonin receptor antagonist",-0.54815,-1.39,0.138,1193,0.6,"ziprasidone, RS.16566, paliperidone, lurasidone, aripiprazole",0.860120913598763,0.221848749616356,FALSE +"H460","Pearson.est","sodium channel blocker",0.22402,0.587,0.935,502,0.959,"brivaracetam, ajmaline, mexiletine, butamben, mepivacaine, cibenzoline",0.0291883891274822,0.0181813928293364,FALSE +"H460","Pearson.est","src inhibitor",-0.35508,-0.909,0.54,1051,0.785,"bosutinib, PP.1, PP.2, masitinib",0.267606240177031,0.105130343254747,FALSE +"H460","Pearson.est","sterol demethylase inhibitor",0.32132,0.853,0.633,18,0.872,"chlormidazole",0.198596289982645,0.0594835150674328,FALSE +"H460","Pearson.est","TGF beta receptor inhibitor",-0.61698,-1.6,0.0562,957,0.342,"repsox, adaprev, SB.431542, SB.525334, D.4476",1.25026368443094,0.465973893943865,FALSE +"H460","Pearson.est","thymidylate synthase inhibitor",-0.2982,-0.763,0.734,430,0.901,"ftorafur, carmofur, raltitrexed, doxifluridine, capecitabine, trifluridine",0.134303940083929,0.045275209020937,FALSE +"H460","Pearson.est","topoisomerase inhibitor",0.27325,0.713,0.816,272,0.938,"mitoxantrone, idarubicin, doxorubicin, exatecan.mesylate, epirubicin, amsacrine",0.0883098412461389,0.0277971616209356,FALSE +"H460","Pearson.est","tubulin polymerization inhibitor",0.3305,0.841,0.62,370,0.826,"BNC105, mebendazole, epothilone.b, oxibendazole, CYT.997, vinorelbine, fenbendazole, verubulin, taltobulin, indibulin",0.207608310501746,0.0830199526796178,FALSE +"H460","Pearson.est","tyrosine kinase inhibitor",-0.25563,-0.645,0.884,1371,0.975,"CP.724714, sunitinib, rheochrysidin",0.0535477349869269,0.0109953843014632,FALSE +"H460","Pearson.est","VEGFR inhibitor",-0.21988,-0.564,0.931,1114,0.986,"MK.2461, lenvatinib, KI.8751, axitinib, tivozanib, foretinib, lucitanib, vatalanib, telatinib, sunitinib",0.0310503190186574,0.0061230850587888,FALSE +"H460","Pearson.est","vitamin D receptor agonist",0.61305,1.61,0.0595,305,0.629,"calcitriol, ercalcitriol, maxacalcitol",1.22548303427145,0.201349354554731,FALSE +"A549","Pearson.est","EGFR inhibitor",0.46438,1.19,0.259,392,0.868,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, erlotinib, BMS.690514, XL.647, canertinib, WZ.3146, gefitinib, brigatinib, AST.1306, PD.168393, pelitinib, icotinib, BIBU.1361, BIBX.1382, afatinib, AZD8931, lapatinib, dacomitinib, rociletinib, osimertinib, GW.583340",0.586700235918748,0.0614802748235081,FALSE +"A549","Pearson.est","Abl kinase inhibitor",0.28995,0.745,0.757,264,0.985,"dasatinib, metatinib, bafetinib",0.120904120499927,0.00656376950238827,FALSE +"A549","Pearson.est","acetylcholine receptor agonist",0.20896,0.529,0.959,149,0.967,"xanomeline",0.0181813928293364,0.0145735259169983,FALSE +"A549","Pearson.est","acetylcholine receptor antagonist",-0.70032,-1.85,0.012,1295,0.166,"dicycloverine, methscopolamine, iododexetimide",1.92081875395238,0.779891911959945,TRUE +"A549","Pearson.est","adenosine receptor antagonist",-0.33739,-0.912,0.541,1433,1,"istradefylline",0.266802734893431,0,FALSE +"A549","Pearson.est","adrenergic receptor agonist",-0.39818,-1.07,0.352,1151,1,"methyldopa, oxymetazoline, ritodrine, norepinephrine, isoetharine",0.453457336521869,0,FALSE +"A549","Pearson.est","adrenergic receptor antagonist",0.35461,0.896,0.567,162,0.943,"practolol, idazoxan, propranolol, vincamine",0.246416941107093,0.0254883072626717,FALSE +"A549","Pearson.est","AKT inhibitor",0.51689,1.32,0.165,391,0.974,"MK.2206, triciribine, AT7867, palomid.529, ONC201, GSK2110183",0.782516055786094,0.0114410431213845,FALSE +"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.33141,-0.863,0.601,1353,0.995,"CEP.37440, DMH1",0.22112552799726,0.00217691925427455,FALSE +"A549","Pearson.est","androgen receptor antagonist",-0.76175,-2.01,0,1190,0.222,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",Inf,0.653647025549361,TRUE +"A549","Pearson.est","antioxidant",-0.56775,-1.46,0.108,1159,0.562,"benfotiamine, trolox",0.96657624451305,0.250263684430939,FALSE +"A549","Pearson.est","AP inhibitor",0.65754,1.7,0.0321,86,1,"birinapant, GDC.0152",1.49349496759513,0,FALSE +"A549","Pearson.est","ATPase inhibitor",0.41795,1.06,0.391,367,0.945,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873",0.407823242604133,0.0245681914907371,FALSE +"A549","Pearson.est","Aurora kinase inhibitor",0.33189,0.864,0.626,526,0.933,"MK.5108, MK.8745, ENMD.2076, barasertib.HQPA, barasertib, alisertib, PF.03814735, ZM.447439, CCT137690, danusertib, SNS.314, MLN.8054",0.20342566678957,0.0301183562535,FALSE +"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34076,-0.899,0.55,1302,1,"azalomycin.b, dirithromycin",0.259637310505756,0,FALSE +"A549","Pearson.est","bacterial DNA gyrase inhibitor",0.41656,1.07,0.368,331,1,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.434152181326482,0,FALSE +"A549","Pearson.est","BCL inhibitor",-0.37198,-0.968,0.479,1408,1,"gossypol, ABT.737",0.319664486585437,0,FALSE +"A549","Pearson.est","Bcr.Abl kinase inhibitor",0.36535,0.944,0.54,264,0.966,"dasatinib, metatinib, bafetinib",0.267606240177031,0.0150228735845067,FALSE +"A549","Pearson.est","benzodiazepine receptor agonist",0.37616,0.988,0.45,169,0.91,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.346787486224656,0.0409586076789064,FALSE +"A549","Pearson.est","bromodomain inhibitor",-0.33911,-0.898,0.561,1135,0.995,"I.BET151, PFI.1",0.251037138743839,0.00217691925427455,FALSE +"A549","Pearson.est","calcium channel blocker",-0.37681,-0.996,0.438,1272,1,"SR.33805, efonidipine.monoethanolate, mibefradil",0.3585258894959,0,FALSE +"A549","Pearson.est","CC chemokine receptor antagonist",-0.28661,-0.77,0.718,413,0.866,"UNBS.5162, MK.0812, ZK811752, RS.504393, SB.225002, navarixin, PF.04136309",0.1438755557577,0.0624821079826534,FALSE +"A549","Pearson.est","CDK inhibitor",-0.23657,-0.626,0.894,1047,0.895,"indirubin, abemaciclib, R547, AZD5438, ribociclib, BMS.265246, TG.02, JNJ.7706621",0.0486624812040823,0.048176964684088,FALSE +"A549","Pearson.est","CHK inhibitor",-0.41062,-1.08,0.382,1146,1,"SCH.900776, AZD7762, SB.218078",0.417936637088291,0,FALSE +"A549","Pearson.est","cyclooxygenase inhibitor",-0.32124,-0.865,0.589,1226,1,"acetylsalicylsalicylic.acid, FR.122047, piroxicam, tryptanthrin, naproxen",0.229884705212898,0,FALSE +"A549","Pearson.est","cytochrome P450 inhibitor",0.54156,1.42,0.122,242,0.781,"PF.4981517, morin, eplerenone",0.913640169325252,0.1073489661227,FALSE +"A549","Pearson.est","DNA alkylating agent",-0.29066,-0.747,0.722,994,0.877,"TH.302, streptozotocin, melphalan, satraplatin, carmustine, cyclophosphamide, temozolomide",0.141462802430361,0.0570004066339595,FALSE +"A549","Pearson.est","DNA inhibitor",-0.27255,-0.727,0.788,1037,0.883,"melphalan, metronidazole, carmustine, busulfan, pibenzimol, nithiamide",0.103473782510445,0.0540392964224314,FALSE +"A549","Pearson.est","DNA methyltransferase inhibitor",0.60527,1.57,0.0699,529,0.797,"SGI.1027, azacitidine, decitabine, fdcyd, RG108",1.15552282425432,0.0985416786038876,FALSE +"A549","Pearson.est","DNA polymerase inhibitor",0.41763,1.08,0.363,234,1,"cidofovir, cephalomannine, foscarnet, idoxuridine",0.440093374963888,0,FALSE +"A549","Pearson.est","DNA synthesis inhibitor",-0.32658,-0.86,0.61,1395,0.964,"altretamine, enocitabine",0.214670164989233,0.0159229660971692,FALSE +"A549","Pearson.est","dopamine receptor antagonist",-0.3761,-0.992,0.456,1148,1,"ziprasidone, mesoridazine, remoxipride, paliperidone, amisulpride, lurasidone",0.341035157335565,0,FALSE +"A549","Pearson.est","estrogen receptor agonist",-0.31673,-0.826,0.66,1152,0.929,"ethinyl.estradiol, estrone, erteberel",0.180456064458131,0.0319842860063582,FALSE +"A549","Pearson.est","estrogen receptor antagonist",-0.75142,-1.97,0.00907,1241,0.148,"danazol, raloxifene, fulvestrant, tamoxifen",2.0423927129399,0.829738284605043,TRUE +"A549","Pearson.est","FGFR inhibitor",-0.24145,-0.629,0.885,1052,0.913,"nintedanib, lenvatinib, MK.2461, lucitanib",0.0530567293021746,0.039529222465701,FALSE +"A549","Pearson.est","FLT3 inhibitor",-0.31889,-0.85,0.647,1187,0.949,"pacritinib, KW.2449, TG.101348, TG.02, lestaurtinib, sunitinib",0.1890957193313,0.0227337875727074,FALSE +"A549","Pearson.est","glucocorticoid receptor agonist",-0.30848,-0.808,0.664,1153,0.904,"beclomethasone.dipropionate, prednisolone.acetate, fluticasone.propionate, fluocinolone.acetonide, flumethasone.pivalate, piretanide, dexamethasone.acetate, hydrocortisone",0.177831920631982,0.0438315695246367,FALSE +"A549","Pearson.est","glutamate receptor antagonist",0.29654,0.759,0.736,339,0.993,"ACDPP, tiletamine, kynurenic.acid, CGP.37849",0.133122185662501,0.00305075150461883,FALSE +"A549","Pearson.est","glycogen synthase kinase inhibitor",0.385,0.989,0.45,34,0.956,"CHIR.99021",0.346787486224656,0.0195421077238999,FALSE +"A549","Pearson.est","growth factor receptor inhibitor",-0.51465,-1.35,0.147,964,0.662,"PHA.848125, GSK1904529A, GSK1838705A, GW.441756, lestaurtinib",0.832682665251824,0.1791420105603,FALSE +"A549","Pearson.est","HCV inhibitor",0.40296,1.03,0.414,78,0.961,"daclatasvir",0.382999658879101,0.0172766123314547,FALSE +"A549","Pearson.est","HDAC inhibitor",0.46623,1.19,0.259,435,0.868,"nexturastat.a, chidamide, panobinostat, belinostat, NSC.3852, SB.939, ACY.1215, entinostat, scriptaid, resminostat, mocetinostat, M.344, givinostat, romidepsin, trichostatin.a",0.586700235918748,0.0614802748235081,FALSE +"A549","Pearson.est","histamine receptor antagonist",-0.23882,-0.636,0.892,985,0.929,"cyproheptadine, lafutidine, ICI.162846, ebastine, tiotidine, terfenadine, ranitidine, BF2.649, epinastine",0.0496351456238769,0.0319842860063582,FALSE +"A549","Pearson.est","HMGCR inhibitor",0.39809,1.01,0.417,200,0.957,"atorvastatin, simvastatin",0.379863945026242,0.0190880622231565,FALSE +"A549","Pearson.est","HSP inhibitor",0.56363,1.46,0.097,208,0.999,"BIIB021, PU.H71, NMS.E973, SNX.2112, ganetespib, SNX.5422, NVP.AUY922",1.01322826573376,0.000434511774017692,FALSE +"A549","Pearson.est","JAK inhibitor",-0.35809,-0.954,0.476,1145,0.999,"CEP.33779, pacritinib, TG.101348, AZD1480, filgotinib, TG.02, lestaurtinib",0.322393047279507,0.000434511774017692,FALSE +"A549","Pearson.est","KIT inhibitor",0.26654,0.675,0.845,101,0.969,"midostaurin, OSI.930, dasatinib",0.0731432910503077,0.0136762229492347,FALSE +"A549","Pearson.est","MDM inhibitor",0.22053,0.57,0.931,1130,0.967,"serdemetan, idasanutlin, AMG.232, CGM097, nutlin.3, RITA",0.0310503190186574,0.0145735259169983,FALSE +"A549","Pearson.est","MEK inhibitor",-0.30755,-0.824,0.635,1202,0.903,"nobiletin, refametinib, BIX.02188, MEK162, arctigenin",0.197226274708024,0.0443122496864942,FALSE +"A549","Pearson.est","MET inhibitor",-0.73841,-1.95,0.00209,1253,0.114,"INC.280, PHA.665752, NVP.BVU972, AMG458",2.67985371388895,0.943095148663527,TRUE +"A549","Pearson.est","microtubule inhibitor",0.41537,1.06,0.36,409,0.945,"estramustine.phosphate, triclabendazole, podophyllotoxin, cabazitaxel",0.443697499232713,0.0245681914907371,FALSE +"A549","Pearson.est","mTOR inhibitor",0.64762,1.66,0.0475,319,0.729,"deforolimus, PI.103, AZD8055, PKI.179, torin.1, everolimus, temsirolimus, NVP.BEZ235, LY3023414, MLN0128, PP242, sirolimus, GDC.0980, AZD2014, torin.2, WYE.125132, SB.2343, voxtalisib",1.32330639037513,0.137272471682025,FALSE +"A549","Pearson.est","NFkB pathway inhibitor",-0.42217,-1.1,0.354,1247,1,"bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.450996737974212,0,FALSE +"A549","Pearson.est","opioid receptor agonist",-0.43523,-1.13,0.305,1291,1,"ADL5859, salvinorin.a",0.515700160653214,0,FALSE +"A549","Pearson.est","p38 MAPK inhibitor",-0.25993,-0.693,0.814,1158,0.885,"TAK.715, skepinone.l",0.0893755951107988,0.0530567293021746,FALSE +"A549","Pearson.est","PARP inhibitor",-0.57161,-1.51,0.0837,946,0.534,"PJ.34, olaparib, niraparib, AZD2461, AG.14361, talazoparib",1.07727454200674,0.272458742971444,FALSE +"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30295,-0.796,0.68,1050,0.872,"imatinib, nintedanib, lenvatinib, axitinib, KI.8751, telatinib, vatalanib, CP.673451, sunitinib, masitinib",0.167491087293764,0.0594835150674328,FALSE +"A549","Pearson.est","phosphatase inhibitor",-0.2668,-0.694,0.824,1424,0.907,"alexidine",0.0840727883028842,0.0423927129399047,FALSE +"A549","Pearson.est","phosphodiesterase inhibitor",0.265,0.673,0.853,379,0.919,"papaverine, enoximone, EMD.53998, cilostamide",0.069050968832477,0.0366844886138887,FALSE +"A549","Pearson.est","PI3K inhibitor",0.35748,0.91,0.553,441,0.997,"PI.103, PKI.179, BGT226, NVP.BEZ235, LY3023414, GDC.0980, SB.2343, voxtalisib, ZSTK.474, PF.04691502, buparlisib, PI3K.IN.2, YM.201636",0.257274868695302,0.00130484168834428,FALSE +"A549","Pearson.est","PLK inhibitor",0.31783,0.811,0.691,990,0.967,"HMN.214, BI.2536, volasertib, GSK461364, rigosertib, NMS.1286937, GW.843682X",0.160521952625802,0.0145735259169983,FALSE +"A549","Pearson.est","potassium channel blocker",0.55091,1.42,0.11,476,0.781,"ibutilide, ML133, oleoylethanolamide, mepivacaine, dofetilide",0.958607314841775,0.1073489661227,FALSE +"A549","Pearson.est","PPAR receptor agonist",-0.32197,-0.834,0.617,1087,0.946,"clofibrate, S26948, fenofibrate",0.209714835966758,0.0241088635982073,FALSE +"A549","Pearson.est","progesterone receptor agonist",-0.58387,-1.55,0.069,1114,0.53,"norgestrel, dienogest, danazol, melengestrol.acetate, nomegestrol.acetate, norethindrone.acetate",1.16115090926274,0.275724130399211,FALSE +"A549","Pearson.est","proteasome inhibitor",0.34747,0.886,0.604,209,0.925,"ONX.0914, MG.132",0.218963061378868,0.0338582672609674,FALSE +"A549","Pearson.est","protein synthesis inhibitor",0.28274,0.73,0.743,445,0.948,"clofoctol, cycloheximide, puromycin, brefeldin.a, thiostrepton, azomycin..2.nitroimidazole., methacycline",0.129011186239425,0.0231916626619338,FALSE +"A549","Pearson.est","protein tyrosine kinase inhibitor",0.26237,0.673,0.866,448,0.919,"AV.412, NVP.TAE226, mubritinib, PP.121, tyrphostin.A9",0.0624821079826534,0.0366844886138887,FALSE +"A549","Pearson.est","RAF inhibitor",0.44895,1.2,0.241,532,1,"SB.590885, vemurafenib, AZ.628, sorafenib, LGX818, regorafenib, PLX.4720, dabrafenib",0.617982957425132,0,FALSE +"A549","Pearson.est","RET tyrosine kinase inhibitor",-0.38283,-1.05,0.351,1409,1,"sunitinib",0.454692883534176,0,FALSE +"A549","Pearson.est","retinoid receptor agonist",0.31555,0.82,0.684,54,0.986,"LE.135",0.164943898279884,0.0061230850587888,FALSE +"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.38449,-1.01,0.427,1442,1,"pentostatin",0.369572124974976,0,FALSE +"A549","Pearson.est","serotonin receptor agonist",-0.68983,-1.77,0.0164,1215,0.212,"NAN.190, ipsapirone, zolmitriptan, aripiprazole",1.7851561519523,0.673664139071249,TRUE +"A549","Pearson.est","serotonin receptor antagonist",-0.41889,-1.1,0.326,1397,1,"lurasidone, aripiprazole",0.486782399932061,0,FALSE +"A549","Pearson.est","sodium channel blocker",0.30915,0.78,0.699,475,0.99,"brivaracetam, ajmaline, cibenzoline, butamben, mepivacaine, mexiletine",0.155522824254319,0.00436480540245009,FALSE +"A549","Pearson.est","src inhibitor",-0.2995,-0.8,0.704,1278,0.892,"PP.2, masitinib",0.152427340857888,0.0496351456238769,FALSE +"A549","Pearson.est","sterol demethylase inhibitor",0.35518,0.906,0.554,13,0.964,"chlormidazole",0.25649023527157,0.0159229660971692,FALSE +"A549","Pearson.est","TGF beta receptor inhibitor",-0.54013,-1.43,0.119,973,0.557,"repsox, SB.431542, adaprev, D.4476, SB.525334",0.924453038607469,0.254144804826271,FALSE +"A549","Pearson.est","thymidylate synthase inhibitor",-0.29057,-0.781,0.702,419,0.872,"ftorafur, doxifluridine, raltitrexed, capecitabine, carmofur, trifluridine",0.153662887870195,0.0594835150674328,FALSE +"A549","Pearson.est","topoisomerase inhibitor",0.26423,0.691,0.83,142,0.977,"mitoxantrone, idarubicin, exatecan.mesylate, doxorubicin",0.0809219076239261,0.0101054362812269,FALSE +"A549","Pearson.est","tubulin polymerization inhibitor",0.49642,1.27,0.208,423,1,"epothilone.b, mebendazole, BNC105, CYT.997, vinorelbine, oxibendazole, taltobulin, verubulin, fenbendazole, dolastatin.10, plinabulin, podophyllotoxin, indibulin, KX2.391, parbendazole, combretastatin.A.4",0.681936665037238,0,FALSE +"A549","Pearson.est","tyrosine kinase inhibitor",0.28736,0.73,0.787,459,0.948,"AV.412, dasatinib, NVP.TAE226, bafetinib, sorafenib, tivantinib, mubritinib, GTP.14564, PP.121, vandetanib, tyrphostin.A9, regorafenib",0.104025267640935,0.0231916626619338,FALSE +"A549","Pearson.est","VEGFR inhibitor",0.22977,0.593,0.939,83,0.975,"BMS.690514, XL.647, OSI.930, SAR131675",0.0273344077338891,0.0109953843014632,FALSE +"A549","Pearson.est","vitamin D receptor agonist",0.46843,1.19,0.267,564,0.868,"calcitriol, ercalcitriol, maxacalcitol, doxercalciferol, tacalcitol",0.573488738635425,0.0614802748235081,FALSE +"HCC44","Pearson.est","EGFR inhibitor",0.42234,1.07,0.365,368,1,"CUDC.101, ARRY.334543, BMS.690514, erlotinib, tyrphostin.AG.1478, XL.647, WZ.3146, canertinib, brigatinib, AST.1306, gefitinib, PD.168393, BIBU.1361, icotinib, lapatinib, AZD8931, pelitinib, afatinib, BIBX.1382, osimertinib",0.437707135543525,0,FALSE +"HCC44","Pearson.est","Abl kinase inhibitor",0.30255,0.766,0.734,217,0.875,"metatinib, dasatinib, bafetinib",0.134303940083929,0.0579919469776868,FALSE +"HCC44","Pearson.est","acetylcholine receptor agonist",-0.24002,-0.621,0.894,1135,0.941,"pilocarpine, nicotine",0.0486624812040823,0.0264103765727431,FALSE +"HCC44","Pearson.est","acetylcholine receptor antagonist",-0.7853,-2.06,0.00202,1306,0.0447,"dicycloverine, methscopolamine, iododexetimide",2.69464863055338,1.34969247686806,TRUE +"HCC44","Pearson.est","adenosine receptor antagonist",0.3631,0.946,0.519,133,0.971,"theophylline, PSB.1115",0.284832642151542,0.0127807700919951,FALSE +"HCC44","Pearson.est","adrenergic receptor agonist",-0.40355,-1.04,0.383,1093,0.952,"oxymetazoline, xylazine, methyldopa, ritodrine, norepinephrine, isoetharine",0.416801226031377,0.0213630516155257,FALSE +"HCC44","Pearson.est","adrenergic receptor antagonist",0.31689,0.826,0.64,211,0.834,"practolol, idazoxan, propranolol, vincamine",0.193820026016113,0.0788339493622613,FALSE +"HCC44","Pearson.est","AKT inhibitor",0.38514,1.01,0.445,505,0.925,"MK.2206, triciribine, ONC201, AT7867, palomid.529, GSK2110183",0.351639989019068,0.0338582672609674,FALSE +"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.33911,-0.872,0.591,1213,0.942,"alectinib, CEP.37440, DMH1",0.228412519118745,0.0259490972071227,FALSE +"HCC44","Pearson.est","androgen receptor antagonist",-0.75662,-1.96,0.00412,1244,0.0804,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",2.38510278396687,1.09474395125155,TRUE +"HCC44","Pearson.est","antioxidant",-0.67595,-1.78,0.0252,1145,0.205,"benfotiamine, trolox",1.59859945921846,0.688246138944246,TRUE +"HCC44","Pearson.est","AP inhibitor",0.64671,1.67,0.0402,59,0.482,"birinapant, GDC.0152",1.39577394691553,0.31695296176115,FALSE +"HCC44","Pearson.est","ATPase inhibitor",0.4248,1.08,0.344,309,1,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873",0.46344155742847,0,FALSE +"HCC44","Pearson.est","Aurora kinase inhibitor",0.2396,0.621,0.877,281,0.926,"MK.5108, MK.8745, barasertib, ENMD.2076, barasertib.HQPA, alisertib",0.0570004066339595,0.0333890133180656,FALSE +"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.32009,-0.805,0.675,1303,0.923,"azalomycin.b, dirithromycin",0.170696227168975,0.0347982989740879,FALSE +"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",0.33904,0.878,0.547,378,0.801,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.262012673666569,0.0963674839157623,FALSE +"HCC44","Pearson.est","BCL inhibitor",-0.37243,-0.958,0.49,1392,0.827,"gossypol, ABT.737",0.309803919971486,0.0824944904474534,FALSE +"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",0.36223,0.931,0.525,217,0.91,"metatinib, dasatinib, bafetinib",0.279840696594043,0.0409586076789064,FALSE +"HCC44","Pearson.est","benzodiazepine receptor agonist",0.45147,1.2,0.243,92,1,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.614393726401688,0,FALSE +"HCC44","Pearson.est","bromodomain inhibitor",-0.46293,-1.17,0.275,939,0.89,"JQ1...., bromosporine, I.BET151, PFI.1",0.560667306169737,0.0506099933550872,FALSE +"HCC44","Pearson.est","calcium channel blocker",-0.29927,-0.76,0.726,1082,0.896,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.139063379299906,0.0476919903378748,FALSE +"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.20333,-0.519,0.968,293,0.971,"ZK811752, UNBS.5162, MK.0812, RS.504393, SB.225002, navarixin, PF.04136309",0.0141246426916063,0.0127807700919951,FALSE +"HCC44","Pearson.est","CDK inhibitor",-0.22962,-0.598,0.919,1044,0.941,"indirubin, AZD5438, R547, abemaciclib, ribociclib, JNJ.7706621, TG.02, BMS.265246",0.0366844886138887,0.0264103765727431,FALSE +"HCC44","Pearson.est","CHK inhibitor",-0.4633,-1.18,0.261,1096,0.928,"SCH.900776, AZD7762, SB.218078",0.583359492661719,0.0324520237811379,FALSE +"HCC44","Pearson.est","cyclooxygenase inhibitor",-0.40278,-1.05,0.368,1222,0.979,"AM.404, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam, naproxen",0.434152181326482,0.00921730819686218,FALSE +"HCC44","Pearson.est","cytochrome P450 inhibitor",0.5424,1.41,0.133,274,0.777,"PF.4981517, morin, eplerenone",0.876148359032914,0.109578981199086,FALSE +"HCC44","Pearson.est","DNA alkylating agent",-0.29081,-0.745,0.752,922,0.873,"mitomycin.c, carmustine, TH.302, melphalan, streptozotocin, satraplatin, cyclophosphamide, temozolomide",0.123782159408358,0.0589857562944303,FALSE +"HCC44","Pearson.est","DNA inhibitor",-0.24104,-0.628,0.882,1354,0.956,"pibenzimol, nithiamide",0.0545314148681803,0.0195421077238999,FALSE +"HCC44","Pearson.est","DNA methyltransferase inhibitor",0.68422,1.77,0.019,380,0.796,"azacitidine, SGI.1027, fdcyd, decitabine",1.72124639904717,0.0990869322623309,FALSE +"HCC44","Pearson.est","DNA polymerase inhibitor",0.35394,0.93,0.501,287,0.833,"foscarnet, cidofovir, cephalomannine, idoxuridine",0.300162274132754,0.0793549985932124,FALSE +"HCC44","Pearson.est","DNA synthesis inhibitor",-0.30236,-0.782,0.723,1368,0.886,"altretamine, enocitabine",0.140861702705469,0.0525662781129492,FALSE +"HCC44","Pearson.est","dopamine receptor antagonist",-0.37702,-0.983,0.455,1034,0.955,"nemonapride, piperacetazine, mesoridazine, ziprasidone, paliperidone, remoxipride, lurasidone, amisulpride",0.341988603342888,0.0199966284162537,FALSE +"HCC44","Pearson.est","estrogen receptor agonist",-0.37549,-0.96,0.499,1143,0.855,"ethinyl.estradiol, estrone, erteberel",0.30189945437661,0.0680338852718274,FALSE +"HCC44","Pearson.est","estrogen receptor antagonist",-0.82612,-2.16,0,1275,0.0317,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.49894073778225,TRUE +"HCC44","Pearson.est","FGFR inhibitor",-0.26592,-0.689,0.829,1013,0.907,"MK.2461, nintedanib, lenvatinib, lucitanib",0.0814454694497265,0.0423927129399047,FALSE +"HCC44","Pearson.est","FLT3 inhibitor",-0.41558,-1.11,0.316,1210,0.99,"pacritinib, quizartinib, TG.101348, KW.2449, TG.02, sunitinib, lestaurtinib",0.500312917381596,0.00436480540245009,FALSE +"HCC44","Pearson.est","glucocorticoid receptor agonist",-0.46204,-1.2,0.263,956,1,"halobetasol.propionate, fludroxycortide, clobetasol.propionate, ciclesonide, triamcinolone.acetonide, desonide, triamcinolone, halcinonide, flumethasone, rimexolone, prednisolone, beclomethasone.dipropionate, prednisolone.acetate, fluticasone.propionate, piretanide, fluocinolone.acetonide, flumethasone.pivalate, dexamethasone.acetate, hydrocortisone",0.580044251510242,0,FALSE +"HCC44","Pearson.est","glutamate receptor antagonist",0.31371,0.803,0.697,311,0.843,"ACDPP, kynurenic.acid, tiletamine, CGP.37849",0.156767221901991,0.0741724253752577,FALSE +"HCC44","Pearson.est","glycogen synthase kinase inhibitor",0.39479,1.01,0.428,34,0.925,"CHIR.99021",0.368556230986828,0.0338582672609674,FALSE +"HCC44","Pearson.est","growth factor receptor inhibitor",-0.58059,-1.48,0.102,978,0.631,"PHA.848125, GSK1904529A, GSK1838705A, GW.441756, lestaurtinib",0.991399828238082,0.199970640755866,FALSE +"HCC44","Pearson.est","HCV inhibitor",0.35954,0.93,0.52,68,0.833,"daclatasvir",0.283996656365201,0.0793549985932124,FALSE +"HCC44","Pearson.est","HDAC inhibitor",0.44767,1.16,0.261,441,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, entinostat, ACY.1215, resminostat, M.344, mocetinostat, romidepsin, givinostat",0.583359492661719,0,FALSE +"HCC44","Pearson.est","histamine receptor antagonist",-0.29298,-0.759,0.74,998,0.875,"lafutidine, cyproheptadine, ICI.162846, ranitidine, tiotidine, terfenadine, ebastine, BF2.649, epinastine",0.130768280269024,0.0579919469776868,FALSE +"HCC44","Pearson.est","HMGCR inhibitor",0.39135,1.01,0.423,212,0.925,"atorvastatin, simvastatin",0.373659632624958,0.0338582672609674,FALSE +"HCC44","Pearson.est","HSP inhibitor",0.50079,1.32,0.17,233,0.908,"BIIB021, NMS.E973, PU.H71, NVP.AUY922, ganetespib, SNX.5422, SNX.2112",0.769551078621726,0.0419141514789149,FALSE +"HCC44","Pearson.est","JAK inhibitor",-0.39231,-1.03,0.396,1170,0.884,"CEP.33779, pacritinib, TG.101348, AZD1480, filgotinib, TG.02, lestaurtinib",0.402304814074488,0.0535477349869269,FALSE +"HCC44","Pearson.est","KIT inhibitor",-0.28597,-0.736,0.785,1100,0.865,"imatinib, KI.8751, lenvatinib, telatinib, vatalanib, sunitinib, masitinib",0.105130343254747,0.0629838925351858,FALSE +"HCC44","Pearson.est","MDM inhibitor",-0.40792,-1.05,0.377,1081,0.979,"nutlin.3, CGM097, RITA",0.423658649794207,0.00921730819686218,FALSE +"HCC44","Pearson.est","MEK inhibitor",-0.30314,-0.804,0.716,1204,0.898,"refametinib, BIX.02188, MEK162, nobiletin, arctigenin",0.145086977692144,0.0467236633326956,FALSE +"HCC44","Pearson.est","MET inhibitor",-0.5702,-1.47,0.0888,1074,0.575,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.0515870342214,0.24033215531037,FALSE +"HCC44","Pearson.est","microtubule inhibitor",0.40027,1.03,0.42,167,1,"estramustine.phosphate, triclabendazole",0.3767507096021,0,FALSE +"HCC44","Pearson.est","mTOR inhibitor",0.68369,1.75,0.037,245,0.455,"deforolimus, PI.103, AZD8055, everolimus, temsirolimus, PKI.179, torin.1, NVP.BEZ235, LY3023414, MLN0128, AZD2014, PP242, GDC.0980, torin.2, sirolimus, WYE.125132, SB.2343",1.431798275933,0.341988603342888,FALSE +"HCC44","Pearson.est","NFkB pathway inhibitor",-0.39656,-1.03,0.397,1006,0.884,"tyloxapol, IKK.2.inhibitor.V, curcumin, bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.401209493236885,0.0535477349869269,FALSE +"HCC44","Pearson.est","opioid receptor agonist",-0.45038,-1.18,0.273,1288,0.928,"ADL5859, salvinorin.a",0.563837352959244,0.0324520237811379,FALSE +"HCC44","Pearson.est","p38 MAPK inhibitor",-0.29318,-0.787,0.699,884,0.902,"SB.242235, talmapimod, CMPD.1, TAK.715, skepinone.l",0.155522824254319,0.0447934624580583,FALSE +"HCC44","Pearson.est","PARP inhibitor",-0.55474,-1.44,0.109,957,0.573,"olaparib, AZD2461, niraparib, AG.14361, talazoparib",0.962573502059376,0.24184537803261,FALSE +"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.3276,-0.84,0.606,1100,0.915,"imatinib, KI.8751, lenvatinib, axitinib, telatinib, vatalanib, CP.673451, sunitinib, masitinib",0.217527375833714,0.0385789059335517,FALSE +"HCC44","Pearson.est","phosphatase inhibitor",-0.37325,-0.974,0.463,1224,0.934,"CID.5458317, menadione, alexidine",0.334419008982047,0.0296531237699066,FALSE +"HCC44","Pearson.est","phosphodiesterase inhibitor",0.26076,0.687,0.827,149,0.906,"papaverine, enoximone",0.0824944904474534,0.0428718023231869,FALSE +"HCC44","Pearson.est","PI3K inhibitor",0.40198,1.04,0.401,393,1,"PI.103, PKI.179, BGT226, NVP.BEZ235, LY3023414, GDC.0980, SB.2343, voxtalisib, buparlisib, ZSTK.474, PF.04691502, PI3K.IN.2, PI.828",0.396855627379818,0,FALSE +"HCC44","Pearson.est","PLK inhibitor",0.36849,0.936,0.506,917,0.945,"HMN.214, BI.2536, volasertib, NMS.1286937, rigosertib, GSK461364, GW.843682X",0.295849483160201,0.0245681914907371,FALSE +"HCC44","Pearson.est","potassium channel blocker",0.59597,1.56,0.0722,410,0.629,"ML133, ibutilide, dofetilide, oleoylethanolamide, mepivacaine",1.14146280243036,0.201349354554731,FALSE +"HCC44","Pearson.est","PPAR receptor agonist",-0.3392,-0.871,0.603,1414,0.913,"fenofibrate",0.219682687859849,0.039529222465701,FALSE +"HCC44","Pearson.est","progesterone receptor agonist",-0.6591,-1.72,0.0322,1176,0.238,"dienogest, norgestrel, danazol, nomegestrol.acetate, melengestrol.acetate, norethindrone.acetate",1.49214412830417,0.623423042943488,TRUE +"HCC44","Pearson.est","proteasome inhibitor",0.36826,0.951,0.498,453,1,"ONX.0914, MG.132, carfilzomib, delanzomib",0.302770657240282,0,FALSE +"HCC44","Pearson.est","protein synthesis inhibitor",0.28748,0.74,0.735,399,0.888,"clofoctol, cycloheximide, brefeldin.a, puromycin, thiostrepton, azomycin..2.nitroimidazole., methacycline",0.133712660915805,0.051587034221399,FALSE +"HCC44","Pearson.est","protein tyrosine kinase inhibitor",-0.30848,-0.827,0.66,1342,0.91,"CP.724714, rheochrysidin",0.180456064458131,0.0409586076789064,FALSE +"HCC44","Pearson.est","RAF inhibitor",0.4578,1.18,0.271,363,1,"SB.590885, vemurafenib, sorafenib, LGX818, dabrafenib, AZ.628",0.567030709125594,0,FALSE +"HCC44","Pearson.est","RET tyrosine kinase inhibitor",-0.34416,-0.91,0.559,1376,0.894,"sunitinib",0.252588192113577,0.0486624812040823,FALSE +"HCC44","Pearson.est","retinoid receptor agonist",0.35099,0.922,0.529,52,0.815,"LE.135",0.276544327964814,0.0888423912600234,FALSE +"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.3821,-0.969,0.483,1442,0.904,"pentostatin",0.316052869248488,0.0438315695246367,FALSE +"HCC44","Pearson.est","serotonin receptor agonist",-0.68095,-1.81,0.0261,1333,0.208,"ipsapirone, zolmitriptan, aripiprazole",1.58335949266172,0.681936665037238,TRUE +"HCC44","Pearson.est","serotonin receptor antagonist",-0.40062,-1.07,0.353,1123,1,"RS.16566, ziprasidone, paliperidone, lurasidone, aripiprazole",0.452225294612177,0,FALSE +"HCC44","Pearson.est","sodium channel blocker",0.34717,0.876,0.566,420,0.775,"brivaracetam, ajmaline, mexiletine, cibenzoline, mepivacaine, butamben",0.247183568811729,0.11069829749369,FALSE +"HCC44","Pearson.est","src inhibitor",-0.37562,-0.968,0.472,1058,0.871,"PP.1, bosutinib, PP.2, masitinib",0.326058001365912,0.0599818449923368,FALSE +"HCC44","Pearson.est","sterol demethylase inhibitor",0.35361,0.903,0.567,11,0.785,"chlormidazole",0.246416941107093,0.105130343254747,FALSE +"HCC44","Pearson.est","TGF beta receptor inhibitor",-0.50895,-1.34,0.175,927,0.736,"repsox, adaprev, SB.431542, SB.525334, D.4476",0.756961951313706,0.133122185662501,FALSE +"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.32386,-0.848,0.615,467,0.929,"ftorafur, raltitrexed, doxifluridine, carmofur, capecitabine, trifluridine",0.211124884224583,0.0319842860063582,FALSE +"HCC44","Pearson.est","topoisomerase inhibitor",0.2717,0.708,0.8,147,0.906,"mitoxantrone, doxorubicin, idarubicin, exatecan.mesylate",0.0969100130080564,0.0428718023231869,FALSE +"HCC44","Pearson.est","tubulin polymerization inhibitor",0.34717,0.903,0.537,532,0.785,"mebendazole, epothilone.b, BNC105, oxibendazole, CYT.997, vinorelbine, fenbendazole, taltobulin, verubulin, indibulin, dolastatin.10, plinabulin, podophyllotoxin, parbendazole, KX2.391",0.270025714300444,0.105130343254747,FALSE +"HCC44","Pearson.est","tyrosine kinase inhibitor",0.25685,0.669,0.846,542,0.901,"dasatinib, AV.412, NVP.TAE226, bafetinib, mubritinib, sorafenib, tivantinib, vandetanib, GTP.14564, tyrphostin.A9, apatinib, PP.121, regorafenib, aminopurvalanol.a",0.0726296369609765,0.045275209020937,FALSE +"HCC44","Pearson.est","VEGFR inhibitor",0.18234,0.473,0.986,142,0.987,"BMS.690514, OSI.930, XL.647, SAR131675",0.0061230850587888,0.00568284733036327,FALSE +"HCC44","Pearson.est","vitamin D receptor agonist",0.59031,1.53,0.0639,251,0.573,"calcitriol, ercalcitriol, maxacalcitol",1.1944991418416,0.24184537803261,FALSE +"H1703","Pearson.est","EGFR inhibitor",0.3917,1.01,0.442,350,0.905,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, BMS.690514, erlotinib, XL.647, WZ.3146, canertinib, brigatinib, AST.1306, gefitinib, BIBU.1361, icotinib, PD.168393, afatinib, BIBX.1382, AZD8931, pelitinib",0.354577730650908,0.0433514207947967,FALSE +"H1703","Pearson.est","Abl kinase inhibitor",0.35264,0.914,0.545,208,0.898,"dasatinib, metatinib, bafetinib",0.263603497723358,0.0467236633326956,FALSE +"H1703","Pearson.est","acetylcholine receptor agonist",0.26271,0.67,0.836,125,0.9,"xanomeline",0.0777937225609836,0.0457574905606751,FALSE +"H1703","Pearson.est","acetylcholine receptor antagonist",-0.75347,-1.95,0.00628,1306,0.149,"dicycloverine, methscopolamine, iododexetimide",2.2020403562628,0.826813731587726,TRUE +"H1703","Pearson.est","adenosine receptor antagonist",-0.34203,-0.912,0.52,1432,0.865,"istradefylline",0.283996656365201,0.0629838925351858,FALSE +"H1703","Pearson.est","adrenergic receptor agonist",-0.37381,-0.961,0.461,1110,0.936,"xylazine, oxymetazoline, methyldopa, ritodrine, norepinephrine, isoetharine",0.336299074610352,0.0287241512618947,FALSE +"H1703","Pearson.est","adrenergic receptor antagonist",0.32906,0.841,0.631,106,0.836,"practolol, propranolol, idazoxan",0.199970640755866,0.0777937225609836,FALSE +"H1703","Pearson.est","AKT inhibitor",0.43614,1.12,0.319,465,1,"MK.2206, triciribine, ONC201, palomid.529, AT7867, GSK2110183",0.496209316942819,0,FALSE +"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.35278,-0.927,0.514,1208,0.899,"alectinib, CEP.37440, DMH1",0.289036881004724,0.0462403082667712,FALSE +"H1703","Pearson.est","androgen receptor antagonist",-0.72989,-1.9,0.011,1173,0.15,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",1.95860731484178,0.823908740944319,TRUE +"H1703","Pearson.est","antioxidant",-0.67218,-1.7,0.031,1154,0.266,"benfotiamine, trolox",1.50863830616573,0.575118363368933,FALSE +"H1703","Pearson.est","AP inhibitor",0.64571,1.61,0.043,34,0.633,"birinapant, GDC.0152",1.36653154442041,0.198596289982645,FALSE +"H1703","Pearson.est","ATPase inhibitor",0.42606,1.08,0.332,361,0.798,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, NMS.873, blebbistatin....",0.478861916295964,0.0979971086492706,FALSE +"H1703","Pearson.est","Aurora kinase inhibitor",0.3383,0.858,0.614,495,0.867,"MK.5108, barasertib.HQPA, barasertib, MK.8745, ENMD.2076, alisertib, PF.03814735, ZM.447439, CCT137690, MLN.8054, SNS.314, danusertib",0.211831628858832,0.0619809025237897,FALSE +"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.36326,-0.952,0.499,1339,0.916,"azalomycin.b, dirithromycin",0.30189945437661,0.0381045263321496,FALSE +"H1703","Pearson.est","bacterial DNA gyrase inhibitor",0.43388,1.11,0.356,355,1,"lomefloxacin, finafloxacin, novobiocin, trovafloxacin",0.448550002027125,0,FALSE +"H1703","Pearson.est","BCL inhibitor",-0.38067,-0.979,0.469,1414,1,"gossypol, ABT.737",0.328827157284917,0,FALSE +"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.41345,1.08,0.327,208,0.798,"dasatinib, metatinib, bafetinib",0.485452247339714,0.0979971086492706,FALSE +"H1703","Pearson.est","benzodiazepine receptor agonist",0.45108,1.17,0.28,110,1,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.552841968657781,0,FALSE +"H1703","Pearson.est","bromodomain inhibitor",-0.40416,-1.07,0.374,1181,1,"I.BET151, PFI.1",0.42712839779952,0,FALSE +"H1703","Pearson.est","calcium channel blocker",-0.34271,-0.897,0.568,1098,0.867,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.245651664288981,0.0619809025237897,FALSE +"H1703","Pearson.est","CC chemokine receptor antagonist",-0.23942,-0.634,0.893,345,0.91,"ZK811752, UNBS.5162, RS.504393, MK.0812, SB.225002, navarixin, PF.04136309",0.0491485411114536,0.0409586076789064,FALSE +"H1703","Pearson.est","CDK inhibitor",-0.24911,-0.665,0.859,1024,0.919,"AZD5438, R547, abemaciclib, indirubin, ribociclib, JNJ.7706621, TG.02, BMS.265246",0.0660068361687577,0.0366844886138887,FALSE +"H1703","Pearson.est","CHK inhibitor",-0.42128,-1.11,0.309,1146,1,"SCH.900776, AZD7762, SB.218078",0.510041520575165,0,FALSE +"H1703","Pearson.est","cyclooxygenase inhibitor",-0.41517,-1.09,0.331,1260,1,"AM.404, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam, naproxen",0.480172006224281,0,FALSE +"H1703","Pearson.est","cytochrome P450 inhibitor",0.58615,1.48,0.0987,256,0.7,"PF.4981517, morin, eplerenone",1.00568284733036,0.154901959985743,FALSE +"H1703","Pearson.est","DNA alkylating agent",-0.36099,-0.928,0.511,969,0.933,"mitomycin.c, TH.302, streptozotocin, carmustine, melphalan, satraplatin, cyclophosphamide, temozolomide",0.291579099865287,0.0301183562535,FALSE +"H1703","Pearson.est","DNA inhibitor",-0.2611,-0.676,0.849,1108,0.975,"carmustine, busulfan, melphalan, pibenzimol, nithiamide",0.0710923097560473,0.0109953843014632,FALSE +"H1703","Pearson.est","DNA methyltransferase inhibitor",0.63296,1.64,0.0398,469,0.806,"azacitidine, SGI.1027, fdcyd, decitabine",1.40011692792631,0.0936649581949093,FALSE +"H1703","Pearson.est","DNA polymerase inhibitor",0.41664,1.08,0.366,261,0.798,"foscarnet, cidofovir, cephalomannine, idoxuridine",0.436518914605589,0.0979971086492706,FALSE +"H1703","Pearson.est","DNA synthesis inhibitor",-0.2624,-0.674,0.819,1322,0.953,"altretamine, enocitabine",0.0867160982395816,0.0209070993616736,FALSE +"H1703","Pearson.est","dopamine receptor antagonist",-0.39495,-1.01,0.436,1178,1,"mesoridazine, remoxipride, ziprasidone, paliperidone, lurasidone, amisulpride",0.360513510731414,0,FALSE +"H1703","Pearson.est","estrogen receptor agonist",-0.28868,-0.765,0.73,1237,0.97,"estrone, erteberel",0.136677139879544,0.0132282657337552,FALSE +"H1703","Pearson.est","estrogen receptor antagonist",-0.82762,-2.22,0,1313,0.0128,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.89279003035213,TRUE +"H1703","Pearson.est","FGFR inhibitor",-0.25452,-0.672,0.852,366,0.932,"orantinib, regorafenib, erdafitinib, AZD4547, PD.173074, dovitinib, MK.2461, lenvatinib, nintedanib, lucitanib",0.0695604052332999,0.0305840876460186,FALSE +"H1703","Pearson.est","FLT3 inhibitor",-0.37732,-1,0.416,1175,1,"KW.2449, TG.101348, quizartinib, pacritinib, TG.02, lestaurtinib, sunitinib",0.380906669373257,0,FALSE +"H1703","Pearson.est","glucocorticoid receptor agonist",-0.40188,-1.04,0.398,976,1,"prednisolone, clobetasol.propionate, desonide, fludroxycortide, halcinonide, triamcinolone.acetonide, triamcinolone, rimexolone, flumethasone, prednisolone.acetate, beclomethasone.dipropionate, fluticasone.propionate, piretanide, fluocinolone.acetonide, dexamethasone.acetate, flumethasone.pivalate, hydrocortisone",0.400116927926312,0,FALSE +"H1703","Pearson.est","glutamate receptor antagonist",0.32877,0.844,0.658,199,0.86,"ACDPP, tiletamine, kynurenic.acid",0.181774106386044,0.0655015487564323,FALSE +"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.38239,0.977,0.481,47,0.888,"CHIR.99021",0.317854923626168,0.051587034221399,FALSE +"H1703","Pearson.est","growth factor receptor inhibitor",-0.57265,-1.46,0.0921,1056,0.471,"GSK1904529A, GSK1838705A, GW.441756, lestaurtinib",1.03574036980315,0.326979092871104,FALSE +"H1703","Pearson.est","HCV inhibitor",0.41707,1.08,0.35,50,0.798,"daclatasvir",0.455931955649724,0.0979971086492706,FALSE +"H1703","Pearson.est","HDAC inhibitor",0.43226,1.14,0.284,459,1,"nexturastat.a, chidamide, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, ACY.1215, entinostat, M.344, resminostat, mocetinostat, romidepsin, givinostat",0.546681659952962,0,FALSE +"H1703","Pearson.est","histamine receptor antagonist",-0.21803,-0.581,0.947,989,0.934,"ICI.162846, cyproheptadine, terfenadine, ranitidine, tiotidine, ebastine, epinastine, BF2.649",0.0236500209967266,0.0296531237699066,FALSE +"H1703","Pearson.est","HMGCR inhibitor",0.35185,0.907,0.551,443,0.875,"atorvastatin, simvastatin, pitavastatin",0.258848401148215,0.0579919469776868,FALSE +"H1703","Pearson.est","HSP inhibitor",0.50593,1.29,0.187,249,1,"BIIB021, NMS.E973, PU.H71, NVP.AUY922, SNX.2112, SNX.5422, ganetespib",0.728158393463501,0,FALSE +"H1703","Pearson.est","JAK inhibitor",-0.35336,-0.918,0.555,1126,0.885,"CEP.33779, TG.101348, pacritinib, AZD1480, filgotinib, TG.02, lestaurtinib",0.255707016877324,0.0530567293021746,FALSE +"H1703","Pearson.est","KIT inhibitor",0.29986,0.758,0.757,66,0.915,"midostaurin, OSI.930, dasatinib",0.120904120499927,0.0385789059335517,FALSE +"H1703","Pearson.est","MDM inhibitor",-0.30836,-0.81,0.681,1032,0.944,"nutlin.3, CGM097, RITA",0.166852888087215,0.025028005701931,FALSE +"H1703","Pearson.est","MEK inhibitor",-0.33577,-0.865,0.611,1214,0.898,"refametinib, BIX.02188, MEK162, nobiletin, arctigenin",0.213958789757446,0.0467236633326956,FALSE +"H1703","Pearson.est","MET inhibitor",-0.6719,-1.77,0.0221,1188,0.218,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.65560772631489,0.661543506395395,TRUE +"H1703","Pearson.est","microtubule inhibitor",0.36874,0.937,0.501,162,0.892,"estramustine.phosphate, triclabendazole",0.300162274132754,0.0496351456238769,FALSE +"H1703","Pearson.est","mTOR inhibitor",0.68585,1.75,0.0173,243,0.825,"deforolimus, PI.103, AZD8055, PKI.179, everolimus, torin.1, temsirolimus, NVP.BEZ235, LY3023414, PP242, MLN0128, AZD2014, GDC.0980, sirolimus, torin.2, WYE.125132, SB.2343",1.7619538968712,0.0835460514500749,FALSE +"H1703","Pearson.est","NFkB pathway inhibitor",-0.4231,-1.12,0.314,1242,1,"bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.503070351926785,0,FALSE +"H1703","Pearson.est","opioid receptor agonist",-0.45721,-1.21,0.228,1256,0.98,"ADL5859, salvinorin.a",0.642065152999546,0.00877392430750515,FALSE +"H1703","Pearson.est","p38 MAPK inhibitor",-0.24359,-0.642,0.879,1311,0.923,"skepinone.l",0.0560111249262281,0.0347982989740879,FALSE +"H1703","Pearson.est","PARP inhibitor",-0.564,-1.46,0.117,993,0.471,"olaparib, niraparib, AZD2461, AG.14361, talazoparib",0.931814138253838,0.326979092871104,FALSE +"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30633,-0.807,0.646,1285,0.922,"vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.189767482004916,0.0352690789463706,FALSE +"H1703","Pearson.est","phosphatase inhibitor",-0.27078,-0.704,0.831,1124,0.988,"menadione, CID.5458317, alexidine",0.080398976215889,0.00524305541237188,FALSE +"H1703","Pearson.est","phosphodiesterase inhibitor",0.25461,0.661,0.84,305,0.885,"papaverine, enoximone, EMD.53998",0.0757207139381184,0.0530567293021746,FALSE +"H1703","Pearson.est","PI3K inhibitor",0.36186,0.945,0.526,404,0.917,"PI.103, PKI.179, NVP.BEZ235, LY3023414, BGT226, GDC.0980, SB.2343, ZSTK.474, voxtalisib, buparlisib, PI3K.IN.2, PF.04691502",0.279014255846261,0.0376306643299789,FALSE +"H1703","Pearson.est","PLK inhibitor",0.34421,0.89,0.57,952,0.872,"HMN.214, BI.2536, volasertib, rigosertib, NMS.1286937, GSK461364, GW.843682X",0.244125144327509,0.0594835150674328,FALSE +"H1703","Pearson.est","potassium channel blocker",0.59544,1.52,0.0578,483,0.737,"ibutilide, ML133, oleoylethanolamide, dofetilide, mepivacaine",1.23807216157947,0.132532512140949,FALSE +"H1703","Pearson.est","PPAR receptor agonist",-0.29107,-0.762,0.721,1405,0.949,"fenofibrate",0.142064735280571,0.0227337875727074,FALSE +"H1703","Pearson.est","progesterone receptor agonist",-0.61981,-1.64,0.0421,1138,0.316,"norgestrel, dienogest, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",1.37571790416433,0.500312917381596,FALSE +"H1703","Pearson.est","proteasome inhibitor",0.3869,1,0.45,462,0.88,"ONX.0914, MG.132, carfilzomib, delanzomib",0.346787486224656,0.0555173278498314,FALSE +"H1703","Pearson.est","protein synthesis inhibitor",0.26634,0.671,0.879,485,0.925,"clofoctol, cycloheximide, brefeldin.a, thiostrepton, puromycin, azomycin..2.nitroimidazole., methacycline, chloramphenicol.palmitate",0.0560111249262281,0.0338582672609674,FALSE +"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.3228,-0.833,0.627,1366,0.93,"CP.724714, rheochrysidin",0.202732459169284,0.0315170514460649,FALSE +"H1703","Pearson.est","RAF inhibitor",0.43075,1.11,0.324,489,1,"SB.590885, vemurafenib, sorafenib, AZ.628, dabrafenib, LGX818, PLX.4720, regorafenib",0.489454989793388,0,FALSE +"H1703","Pearson.est","RET tyrosine kinase inhibitor",-0.37158,-0.975,0.462,1412,0.988,"sunitinib",0.335358024443874,0.00524305541237188,FALSE +"H1703","Pearson.est","retinoid receptor agonist",0.27695,0.699,0.829,64,0.972,"LE.135",0.0814454694497265,0.0123337350737254,FALSE +"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.36668,-0.964,0.442,1442,0.971,"pentostatin",0.354577730650908,0.0127807700919951,FALSE +"H1703","Pearson.est","serotonin receptor agonist",-0.67935,-1.78,0.017,1316,0.254,"zolmitriptan, ipsapirone, aripiprazole",1.76955107862173,0.595166283380062,FALSE +"H1703","Pearson.est","serotonin receptor antagonist",-0.44733,-1.16,0.278,1245,1,"ziprasidone, paliperidone, lurasidone, aripiprazole",0.555955204081924,0,FALSE +"H1703","Pearson.est","sodium channel blocker",0.32249,0.838,0.646,494,0.813,"brivaracetam, ajmaline, cibenzoline, butamben, mepivacaine, mexiletine",0.189767482004916,0.0899094544059319,FALSE +"H1703","Pearson.est","src inhibitor",-0.26879,-0.694,0.838,1422,0.976,"masitinib",0.0767559813697235,0.0105501823333082,FALSE +"H1703","Pearson.est","sterol demethylase inhibitor",0.34352,0.866,0.615,10,0.885,"chlormidazole",0.211124884224583,0.0530567293021746,FALSE +"H1703","Pearson.est","TGF beta receptor inhibitor",-0.62423,-1.61,0.0591,1047,0.32,"adaprev, repsox, SB.431542, SB.525334, D.4476",1.22841251911874,0.494850021680094,FALSE +"H1703","Pearson.est","thymidylate synthase inhibitor",-0.28363,-0.756,0.738,409,0.933,"ftorafur, raltitrexed, doxifluridine, carmofur, capecitabine, trifluridine",0.131943638176958,0.0301183562535,FALSE +"H1703","Pearson.est","topoisomerase inhibitor",0.26859,0.678,0.846,175,0.943,"mitoxantrone, idarubicin, doxorubicin, exatecan.mesylate",0.0726296369609765,0.0254883072626717,FALSE +"H1703","Pearson.est","tubulin polymerization inhibitor",0.41783,1.09,0.333,286,1,"mebendazole, epothilone.b, BNC105, oxibendazole, vinorelbine, CYT.997, fenbendazole, taltobulin, verubulin, indibulin",0.47755576649368,0,FALSE +"H1703","Pearson.est","tyrosine kinase inhibitor",0.26733,0.694,0.819,543,0.95,"dasatinib, AV.412, NVP.TAE226, bafetinib, sorafenib, mubritinib, GTP.14564, tivantinib, apatinib, tyrphostin.A9, vandetanib, regorafenib, PP.121, aminopurvalanol.a",0.0867160982395816,0.0222763947111523,FALSE +"H1703","Pearson.est","VEGFR inhibitor",0.23303,0.602,0.898,84,0.917,"BMS.690514, OSI.930, XL.647, SAR131675",0.0467236633326956,0.0376306643299789,FALSE +"H1703","Pearson.est","vitamin D receptor agonist",0.44362,1.14,0.291,440,1,"ercalcitriol, calcitriol, maxacalcitol",0.536107011014093,0,FALSE +"H1299","Pearson.est","EGFR inhibitor",0.37448,0.983,0.446,268,1,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, BMS.690514, erlotinib, WZ.3146, XL.647, canertinib, gefitinib, brigatinib, PD.168393, AST.1306, icotinib, BIBX.1382, BIBU.1361",0.350665141287858,0,FALSE +"H1299","Pearson.est","Abl kinase inhibitor",-0.23072,-0.597,0.933,1015,0.983,"bosutinib, ponatinib, imatinib, KW.2449, flumatinib",0.0301183562535,0.00744648216786438,FALSE +"H1299","Pearson.est","acetylcholine receptor agonist",0.21122,0.541,0.95,150,0.989,"xanomeline",0.0222763947111523,0.0048037084028206,FALSE +"H1299","Pearson.est","acetylcholine receptor antagonist",-0.74436,-1.91,0.00358,1345,0.17,"dicycloverine, iododexetimide, methscopolamine",2.44611697335613,0.769551078621726,TRUE +"H1299","Pearson.est","adenosine receptor antagonist",-0.38585,-1,0.419,1208,0.812,"sulmazole, istradefylline",0.377785977033705,0.0904439707588247,FALSE +"H1299","Pearson.est","adrenergic receptor agonist",-0.39671,-1.02,0.429,1115,0.871,"xylazine, methyldopa, ritodrine, oxymetazoline, norepinephrine, isoetharine",0.367542707815276,0.0599818449923368,FALSE +"H1299","Pearson.est","adrenergic receptor antagonist",0.34441,0.886,0.577,184,0.871,"practolol, idazoxan, propranolol, vincamine",0.238824186844269,0.0599818449923368,FALSE +"H1299","Pearson.est","AKT inhibitor",0.35029,0.908,0.55,488,1,"triciribine, MK.2206, ONC201, GSK2110183, palomid.529, AT7867",0.259637310505756,0,FALSE +"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.38801,-1,0.45,1212,0.812,"alectinib, CEP.37440, DMH1",0.346787486224656,0.0904439707588247,FALSE +"H1299","Pearson.est","androgen receptor antagonist",-0.71733,-1.87,0.0121,1054,0.16,"bicalutamide, nilutamide, flutamide, enzalutamide, cyproterone.acetate",1.91721462968355,0.795880017344075,TRUE +"H1299","Pearson.est","antioxidant",-0.64598,-1.73,0.0335,1201,0.259,"benfotiamine, trolox",1.47495519296315,0.586700235918748,FALSE +"H1299","Pearson.est","AP inhibitor",0.66205,1.7,0.0278,49,0.615,"birinapant, GDC.0152",1.55595520408192,0.211124884224583,FALSE +"H1299","Pearson.est","ATPase inhibitor",0.4381,1.13,0.294,280,1,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin....",0.531652669587843,0,FALSE +"H1299","Pearson.est","Aurora kinase inhibitor",0.24364,0.631,0.879,448,0.975,"MK.5108, MK.8745, barasertib, barasertib.HQPA, alisertib, ENMD.2076, MLN.8054, PF.03814735, ZM.447439",0.0560111249262281,0.0109953843014632,FALSE +"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.42062,-1.08,0.35,1363,1,"azalomycin.b, dirithromycin",0.455931955649724,0,FALSE +"H1299","Pearson.est","bacterial DNA gyrase inhibitor",0.44068,1.15,0.289,182,1,"lomefloxacin, novobiocin, finafloxacin",0.539102157243452,0,FALSE +"H1299","Pearson.est","BCL inhibitor",-0.38806,-1.02,0.405,1403,0.871,"gossypol, ABT.737",0.392544976785331,0.0599818449923368,FALSE +"H1299","Pearson.est","Bcr.Abl kinase inhibitor",0.26417,0.7,0.825,259,0.951,"dasatinib, metatinib, bafetinib",0.0835460514500749,0.0218194830625861,FALSE +"H1299","Pearson.est","benzodiazepine receptor agonist",0.41638,1.07,0.363,124,1,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.440093374963888,0,FALSE +"H1299","Pearson.est","bromodomain inhibitor",-0.584,-1.5,0.0883,988,0.418,"JQ1...., bromosporine, I.BET151, PFI.1",1.05403929642243,0.378823718224965,FALSE +"H1299","Pearson.est","calcium channel blocker",-0.39087,-1.01,0.417,1122,0.856,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.379863945026242,0.0675262353228468,FALSE +"H1299","Pearson.est","CC chemokine receptor antagonist",-0.18752,-0.484,0.988,962,0.984,"navarixin, SB.225002, PF.04136309",0.00524305541237188,0.00700490156865849,FALSE +"H1299","Pearson.est","CDK inhibitor",-0.32419,-0.823,0.639,1076,0.854,"R547, AZD5438, indirubin, abemaciclib, ribociclib, BMS.265246, JNJ.7706621, TG.02",0.1944991418416,0.068542129310995,FALSE +"H1299","Pearson.est","CHK inhibitor",-0.41612,-1.07,0.373,1052,0.973,"SCH.900776, AZD7762, SB.218078",0.428291168191312,0.0118871597316481,FALSE +"H1299","Pearson.est","cyclooxygenase inhibitor",-0.41186,-1.04,0.39,1233,1,"AM.404, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam, naproxen",0.408935392973501,0,FALSE +"H1299","Pearson.est","cytochrome P450 inhibitor",0.51428,1.34,0.157,282,0.95,"PF.4981517, morin, eplerenone",0.804100347590766,0.0222763947111523,FALSE +"H1299","Pearson.est","DNA alkylating agent",-0.3376,-0.887,0.558,944,0.767,"mitomycin.c, estramustine, carmustine, TH.302, melphalan, streptozotocin, satraplatin, cyclophosphamide, temozolomide",0.253365801062421,0.115204636051019,FALSE +"H1299","Pearson.est","DNA inhibitor",-0.21955,-0.578,0.942,1357,0.977,"nithiamide, pibenzimol",0.0259490972071227,0.0101054362812269,FALSE +"H1299","Pearson.est","DNA methyltransferase inhibitor",0.61893,1.64,0.0581,507,0.426,"azacitidine, fdcyd, decitabine, SGI.1027",1.23582386760967,0.370590400897281,FALSE +"H1299","Pearson.est","DNA polymerase inhibitor",0.37341,0.979,0.457,141,1,"foscarnet, cephalomannine, cidofovir",0.34008379993015,0,FALSE +"H1299","Pearson.est","DNA synthesis inhibitor",0.20094,0.518,0.964,229,0.972,"estramustine.phosphate, cisplatin, artemisinin",0.0159229660971692,0.0123337350737254,FALSE +"H1299","Pearson.est","dopamine receptor antagonist",-0.40335,-1.03,0.411,1176,0.93,"mesoridazine, ziprasidone, remoxipride, paliperidone, amisulpride, lurasidone",0.386158178123931,0.0315170514460649,FALSE +"H1299","Pearson.est","estrogen receptor agonist",-0.40718,-1.03,0.395,1276,0.93,"estrone, erteberel",0.40340290437354,0.0315170514460649,FALSE +"H1299","Pearson.est","estrogen receptor antagonist",-0.84597,-2.16,0,1283,0.0288,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.54060751224077,TRUE +"H1299","Pearson.est","FGFR inhibitor",-0.3918,-0.992,0.459,1019,0.769,"MK.2461, nintedanib, lenvatinib, lucitanib",0.338187314462739,0.114073660198569,FALSE +"H1299","Pearson.est","FLT3 inhibitor",-0.38371,-0.983,0.473,1151,0.735,"TG.101348, quizartinib, KW.2449, pacritinib, TG.02, sunitinib, lestaurtinib",0.325138859262188,0.133712660915805,FALSE +"H1299","Pearson.est","glucocorticoid receptor agonist",-0.38006,-0.989,0.458,883,0.749,"clobetasol.propionate, desonide, triamcinolone.acetonide, halobetasol.propionate, fludroxycortide, triamcinolone, halcinonide, flumethasone, prednisolone, rimexolone, prednisolone.acetate, beclomethasone.dipropionate, fluticasone.propionate, fluocinolone.acetonide, piretanide, hydrocortisone, dexamethasone.acetate, flumethasone.pivalate",0.339134521996131,0.125518182300534,FALSE +"H1299","Pearson.est","glutamate receptor antagonist",0.30866,0.839,0.6,202,0.923,"ACDPP, tiletamine, kynurenic.acid",0.221848749616356,0.0347982989740879,FALSE +"H1299","Pearson.est","glycogen synthase kinase inhibitor",0.34347,0.891,0.579,54,0.943,"CHIR.99021",0.237321436272564,0.0254883072626717,FALSE +"H1299","Pearson.est","growth factor receptor inhibitor",-0.64068,-1.67,0.0306,1263,0.259,"GSK1838705A, GW.441756, lestaurtinib",1.51427857351842,0.586700235918748,FALSE +"H1299","Pearson.est","HCV inhibitor",0.33246,0.888,0.576,83,0.906,"daclatasvir",0.239577516576788,0.0428718023231869,FALSE +"H1299","Pearson.est","HDAC inhibitor",0.42765,1.13,0.313,388,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, scriptaid, SB.939, entinostat, ACY.1215, romidepsin, mocetinostat, resminostat",0.504455662453552,0,FALSE +"H1299","Pearson.est","histamine receptor antagonist",-0.29824,-0.77,0.706,1031,0.897,"lafutidine, terfenadine, ranitidine, ICI.162846, tiotidine, epinastine, ebastine, BF2.649",0.151195298948196,0.0472075569559079,FALSE +"H1299","Pearson.est","HMGCR inhibitor",0.40347,1.06,0.394,189,1,"atorvastatin, simvastatin",0.404503778174426,0,FALSE +"H1299","Pearson.est","HSP inhibitor",0.41032,1.09,0.348,241,1,"BIIB021, NMS.E973, PU.H71, SNX.2112, NVP.AUY922, ganetespib",0.458420756053419,0,FALSE +"H1299","Pearson.est","JAK inhibitor",-0.38159,-0.979,0.473,1127,0.696,"CEP.33779, TG.101348, pacritinib, AZD1480, filgotinib, TG.02, lestaurtinib",0.325138859262188,0.157390760389438,FALSE +"H1299","Pearson.est","KIT inhibitor",-0.36174,-0.936,0.528,1123,0.747,"KI.8751, imatinib, lenvatinib, vatalanib, telatinib, sunitinib, masitinib",0.277366077466188,0.126679398184601,FALSE +"H1299","Pearson.est","MDM inhibitor",-0.28277,-0.728,0.797,1057,0.918,"nutlin.3, CGM097, RITA",0.0985416786038876,0.0371573187987575,FALSE +"H1299","Pearson.est","MEK inhibitor",-0.24697,-0.635,0.904,1202,0.991,"MEK162, BIX.02188, nobiletin, arctigenin",0.0438315695246367,0.00392634551472468,FALSE +"H1299","Pearson.est","MET inhibitor",-0.66753,-1.71,0.0443,1105,0.243,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.35359627377693,0.614393726401688,TRUE +"H1299","Pearson.est","microtubule inhibitor",0.36949,0.944,0.49,159,1,"estramustine.phosphate, triclabendazole",0.309803919971486,0,FALSE +"H1299","Pearson.est","mTOR inhibitor",0.68512,1.79,0.0148,208,0.722,"deforolimus, PI.103, AZD8055, torin.1, PKI.179, everolimus, temsirolimus, NVP.BEZ235, PP242, LY3023414, MLN0128, sirolimus, SB.2343, AZD2014, GDC.0980, torin.2",1.82973828460504,0.141462802430361,FALSE +"H1299","Pearson.est","NFkB pathway inhibitor",-0.44207,-1.16,0.269,1264,0.902,"Ro.106.9920, bindarit, parthenolide, betulinic.acid",0.570247719997592,0.0447934624580583,FALSE +"H1299","Pearson.est","opioid receptor agonist",-0.45925,-1.17,0.277,1267,0.937,"ADL5859, salvinorin.a",0.557520230935551,0.0282604091122217,FALSE +"H1299","Pearson.est","p38 MAPK inhibitor",-0.29184,-0.735,0.781,1341,0.93,"skepinone.l",0.1073489661227,0.0315170514460649,FALSE +"H1299","Pearson.est","PARP inhibitor",-0.55827,-1.47,0.0978,860,0.43,"PJ.34, E7449, olaparib, niraparib, AZD2461, AG.14361, talazoparib",1.0096611452124,0.366531544420413,FALSE +"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.43677,-1.17,0.282,1041,0.937,"nintedanib, ponatinib, crenolanib, KI.8751, imatinib, lenvatinib, axitinib, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.549750891680639,0.0282604091122217,FALSE +"H1299","Pearson.est","phosphatase inhibitor",-0.34135,-0.891,0.554,1181,0.781,"menadione, CID.5458317, alexidine",0.25649023527157,0.1073489661227,FALSE +"H1299","Pearson.est","phosphodiesterase inhibitor",0.2109,0.543,0.964,329,1,"papaverine, enoximone, EMD.53998",0.0159229660971692,0,FALSE +"H1299","Pearson.est","PI3K inhibitor",0.35513,0.914,0.529,188,1,"PI.103, PKI.179, NVP.BEZ235, BGT226, LY3023414, SB.2343, GDC.0980",0.276544327964814,0,FALSE +"H1299","Pearson.est","PLK inhibitor",0.34698,0.901,0.569,948,0.967,"HMN.214, BI.2536, volasertib, GSK461364, NMS.1286937, rigosertib, GW.843682X",0.244887733604929,0.0145735259169983,FALSE +"H1299","Pearson.est","potassium channel blocker",0.56102,1.46,0.103,387,0.749,"ML133, ibutilide, oleoylethanolamide, dofetilide",0.987162775294828,0.125518182300534,FALSE +"H1299","Pearson.est","PPAR receptor agonist",-0.3185,-0.82,0.66,1398,0.837,"fenofibrate",0.180456064458131,0.07727454200674,FALSE +"H1299","Pearson.est","progesterone receptor agonist",-0.61916,-1.6,0.0472,1139,0.288,"dienogest, norgestrel, melengestrol.acetate, nomegestrol.acetate, danazol, norethindrone.acetate",1.32605800136591,0.540607512240769,FALSE +"H1299","Pearson.est","proteasome inhibitor",0.31373,0.811,0.645,220,0.868,"ONX.0914, MG.132",0.190440285364732,0.0614802748235081,FALSE +"H1299","Pearson.est","protein synthesis inhibitor",0.28793,0.742,0.775,441,0.92,"clofoctol, cycloheximide, brefeldin.a, thiostrepton, chloramphenicol.palmitate, methacycline, azomycin..2.nitroimidazole., puromycin",0.11069829749369,0.0362121726544447,FALSE +"H1299","Pearson.est","protein tyrosine kinase inhibitor",-0.34845,-0.891,0.564,1375,0.781,"CP.724714, rheochrysidin",0.248720896016658,0.1073489661227,FALSE +"H1299","Pearson.est","RAF inhibitor",0.31917,0.829,0.64,483,0.904,"SB.590885, vemurafenib, LGX818, sorafenib, AZ.628, dabrafenib",0.193820026016113,0.0438315695246367,FALSE +"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.44339,-1.18,0.264,1393,1,"sunitinib",0.578396073130169,0,FALSE +"H1299","Pearson.est","retinoid receptor agonist",0.39242,1.04,0.389,48,1,"LE.135",0.410050398674292,0,FALSE +"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.38982,-0.993,0.449,1441,0.795,"pentostatin",0.347753658996677,0.0996328713435297,FALSE +"H1299","Pearson.est","serotonin receptor agonist",-0.6795,-1.76,0.0153,1344,0.273,"zolmitriptan, ipsapirone, aripiprazole",1.8153085691824,0.563837352959244,FALSE +"H1299","Pearson.est","serotonin receptor antagonist",-0.44142,-1.12,0.317,1164,0.95,"RS.16566, ziprasidone, paliperidone, lurasidone, aripiprazole",0.498940737782249,0.0222763947111523,FALSE +"H1299","Pearson.est","sodium channel blocker",0.30459,0.822,0.651,343,0.883,"brivaracetam, ajmaline, mexiletine, cibenzoline, butamben",0.186419011431808,0.0540392964224314,FALSE +"H1299","Pearson.est","src inhibitor",-0.38289,-0.98,0.434,986,0.717,"TG.100572, bosutinib, PP.1, PP.2, masitinib",0.362510270487489,0.1444808443322,FALSE +"H1299","Pearson.est","sterol demethylase inhibitor",0.30889,0.8,0.669,23,0.856,"chlormidazole",0.174573882232177,0.0675262353228468,FALSE +"H1299","Pearson.est","TGF beta receptor inhibitor",-0.64372,-1.66,0.0516,950,0.24,"repsox, adaprev, SB.431542, SB.525334, D.4476",1.28735029837279,0.619788758288394,FALSE +"H1299","Pearson.est","thymidylate synthase inhibitor",-0.24064,-0.621,0.908,347,0.983,"ftorafur, doxifluridine, raltitrexed, carmofur, capecitabine, trifluridine",0.0419141514789149,0.00744648216786438,FALSE +"H1299","Pearson.est","topoisomerase inhibitor",0.23711,0.635,0.904,187,1,"mitoxantrone, doxorubicin, idarubicin, exatecan.mesylate",0.0438315695246367,0,FALSE +"H1299","Pearson.est","tubulin polymerization inhibitor",0.36452,0.926,0.519,457,1,"mebendazole, epothilone.b, BNC105, oxibendazole, CYT.997, vinorelbine, fenbendazole, indibulin, verubulin, taltobulin, podophyllotoxin, dolastatin.10, plinabulin",0.284832642151542,0,FALSE +"H1299","Pearson.est","tyrosine kinase inhibitor",-0.25715,-0.655,0.859,1375,0.991,"CP.724714, sunitinib, rheochrysidin",0.0660068361687577,0.00392634551472468,FALSE +"H1299","Pearson.est","VEGFR inhibitor",-0.22553,-0.572,0.949,1123,0.96,"KI.8751, lenvatinib, tivozanib, axitinib, foretinib, vatalanib, lucitanib, telatinib, sunitinib",0.0227337875727074,0.0177287669604316,FALSE +"H1299","Pearson.est","vitamin D receptor agonist",0.66456,1.67,0.0251,246,0.477,"ercalcitriol, calcitriol, maxacalcitol",1.60032627851896,0.321481620959886,FALSE diff --git a/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_venn_diagram.pdf b/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_venn_diagram.pdf new file mode 100644 index 0000000000000000000000000000000000000000..c5952e9fbf53aa29c13b33c44475269fff40b49e GIT binary patch literal 7591 zcmZ{pWn5Hi*N16jkVXL|h7=GOx}>DLyJQ#!7#SFtpu436qy!{H2^A4hkrpY*p+l4w zkdTtDckmp~InQ(6XMfuFf3LdN{<5y$;x<%O7Zec^2XKeYh0TXy!-i~;01==t5aDVE=elvxk;W#g2pav4` 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a/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_interactive_network.graph.html b/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_interactive_network.graph.html new file mode 100644 index 0000000..62ca00b --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_interactive_network.graph.html @@ -0,0 +1,5318 @@ + + + + +visNetwork + + + + + + + +

+
+
+ + + + diff --git a/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_mean_results.csv b/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..95c2482 --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"FGFR inhibitor",0.906933333333333,0.854294986412494,0.0396935658613573,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.131782638659706 +"calcium channel blocker",0.669066666666667,0.764335515956429,0.718995992285689,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"protein tyrosine kinase inhibitor",0.6564,0.939729277124914,0.255355467923227,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.492895438084369 +"glucocorticoid receptor agonist",0.6138,1.18168682097125,0.00718308919049664,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0350703766359542 +"ATPase inhibitor",0.577733333333333,1.52591609330576,1.68607565966016e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1650, H2009, H358, H1299, H1703",6.99721398758967e-06 +"BCL inhibitor",0.5258,0.941638935959153,0.485585206952129,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.732792221400485 +"phosphatase inhibitor",0.4896,0.8541608078777,0.840904564162789,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"VEGFR inhibitor",0.412133333333333,0.628340884127928,0.999866235270498,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"PPAR receptor agonist",0.405866666666667,1.26729553812533,0.00455847173507005,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, HCC44",0.0270252252864867 +"serotonin receptor agonist",0.343466666666667,1.38500762590302,0.000588750424142963,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.00640193307478055 +"progesterone receptor agonist",0.339066666666667,1.24491276037816,0.0213166434445007,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.080421882086071 +"benzodiazepine receptor agonist",0.337533333333333,0.927542595607699,0.84214452437271,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"adenosine receptor antagonist",0.322733333333333,1.34172173326805,0.0195544673228818,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0772867041809139 +"TGF beta receptor inhibitor",0.3216,1.57032798211984,0.000246250493721987,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1975, H2126, A549, HCC44, H460",0.00340646516315415 +"src inhibitor",0.2944,0.962872992663103,0.808986370631176,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"cytochrome P450 inhibitor",0.232,1.15200942456462,0.202547823423821,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.410035837662858 +"acetylcholine receptor agonist",0.209266666666667,1.11106046297263,0.365240456250648,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.644999103591571 +"acetylcholine receptor antagonist",0.2044,1.3579660105151,0.0225333688130711,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1975, HCC44, H460",0.081316070064561 +"adrenergic receptor antagonist",0.202133333333333,0.868700578587407,0.987390223689633,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"PDGFR tyrosine kinase receptor inhibitor",0.193333333333333,0.838695472289016,0.993267927562213,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"bromodomain inhibitor",0.160933333333333,1.2071654796415,0.0930908930682079,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.234137700747311 +"serotonin receptor antagonist",0.110733333333333,1.04811936797476,0.681789041162975,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.992780533623279 +"FLT3 inhibitor",0.0957333333333333,0.803696768214291,0.999505129073447,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"NFkB pathway inhibitor",0.0772666666666667,1.00282247871172,0.813097249720832,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"adrenergic receptor agonist",0.0741333333333333,0.921820471107244,0.970126212481252,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"glutamate receptor antagonist",0.0694666666666667,1.10560028082141,0.4456006573628,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.711986536439988 +"Abl kinase inhibitor",0.0692,0.999047346225393,0.732355202805763,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.99993046379352 +"sodium channel blocker",0.0672,0.775115954459165,0.999890448772568,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"EGFR inhibitor",0.0556666666666666,1.18356390778425,0.148291609268001,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.341894543590114 +"JAK inhibitor",0.0548000000000001,0.813014601872035,0.999292762714507,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"AP inhibitor",0.0368,1.19773620992747,0.134105023630439,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.327374028274306 +"DNA polymerase inhibitor",0.0345333333333333,1.08310294106903,0.460110425658606,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.720550289238949 +"tyrosine kinase inhibitor",0.0322,0.768510079866974,0.99993046379352,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"phosphodiesterase inhibitor",0.0178,1.14608384136091,0.235595172091122,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.465580935322931 +"androgen receptor antagonist",0.0137333333333333,1.10150951404144,0.446063854155173,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.711986536439988 +"KIT inhibitor",-0.00260000000000007,0.91661222522317,0.969847472330129,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"growth factor receptor inhibitor",-0.0062,1.26665917165702,0.0441582097304621,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1650, H460, H520",0.135363519744558 +"protein synthesis inhibitor",-0.0248,1.00625445518091,0.789642037971312,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"RAF inhibitor",-0.0608666666666667,1.24537543775055,0.0743150575986443,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.198972573570564 +"estrogen receptor antagonist",-0.079,1.1693266682766,0.173377583987051,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.368983063357057 +"CHK inhibitor",-0.0821333333333333,1.2904897667534,0.011720670404108,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.0497579785927863 +"bacterial 50S ribosomal subunit inhibitor",-0.0926666666666667,1.00001640462735,0.835424087205858,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"HCV inhibitor",-0.112533333333333,1.56347515246676,9.13851410698753e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H1703",2.52832223626655e-05 +"microtubule inhibitor",-0.140466666666667,0.964089642147056,0.881634740228835,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"retinoid receptor agonist",-0.140933333333333,1.25581814349205,0.0456648018415377,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.135363519744558 +"dopamine receptor antagonist",-0.162133333333333,0.949306503767481,0.91447544916416,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"proteasome inhibitor",-0.171066666666667,1.3877890158021,0.00010585618528265,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.00175721267569198 +"sterol demethylase inhibitor",-0.176133333333333,1.38625326827731,0.00122163673572184,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2126, H1299",0.00921780446044664 +"tubulin polymerization inhibitor",-0.2002,1.1915180713215,0.0865375480389498,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.224456765226026 +"RET tyrosine kinase inhibitor",-0.2096,1.16022656654392,0.16357980376848,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.366949289534699 +"histamine receptor antagonist",-0.217266666666667,1.25321777076148,0.0415773699308154,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.132727757856065 +"Bcr.Abl kinase inhibitor",-0.236,1.02768491558176,0.485567344891289,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.732792221400485 +"antioxidant",-0.268066666666667,1.34566619012224,0.00186573341751068,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1975, HCC44",0.0129046561377822 +"thymidylate synthase inhibitor",-0.2888,1.56362153806019,6.32468123223936e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1975, H2009, H520",5.24948542275867e-06 +"potassium channel blocker",-0.289666666666667,1.27384831271605,0.0094593736303801,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0436182228511971 +"AKT inhibitor",-0.301733333333333,1.06989995972031,0.419216790362892,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.710101910206531 +"vitamin D receptor agonist",-0.321866666666667,1.28030626172394,0.0119898743597075,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC15",0.0497579785927863 +"mTOR inhibitor",-0.3262,0.969587408569822,0.699832991155403,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"PLK inhibitor",-0.3266,1.72261320590052,2.41831614238838e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,7,"H1650, H1975, H2126, A549, HCC15, HCC44, H520",5.01800599545588e-05 +"glycogen synthase kinase inhibitor",-0.327333333333333,1.19282813195404,0.061643204052963,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.170546197879864 +"ribonucleotide reductase inhibitor",-0.329933333333333,1.0639181269968,0.381561809861436,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.659783962885399 +"PI3K inhibitor",-0.3306,0.729006741101499,0.99907974070906,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"DNA methyltransferase inhibitor",-0.3432,1.34270070061372,0.000877609666336268,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H3255",0.00809351136732336 +"ALK tyrosine kinase receptor inhibitor",-0.3686,0.8960289217271,0.886439888369425,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"CDK inhibitor",-0.3694,0.922757497937567,0.835524921577286,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"opioid receptor agonist",-0.371866666666667,1.05995241582324,0.290289021335075,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.523782364582852 +"DNA inhibitor",-0.386466666666667,1.07833336130124,0.285843393693962,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.523782364582852 +"HSP inhibitor",-0.387533333333333,1.05875667423544,0.278232706670768,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.523782364582852 +"DNA alkylating agent",-0.4264,0.992701782294879,0.512117411498631,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.759031163471185 +"cyclooxygenase inhibitor",-0.4438,0.787414594008228,0.975097561360289,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"Aurora kinase inhibitor",-0.452466666666667,0.964798710810163,0.443235491383775,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.711986536439988 +"HMGCR inhibitor",-0.458066666666667,1.18249243227217,0.0571971980024561,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H1975",0.163702325317374 +"CC chemokine receptor antagonist",-0.474533333333333,1.07032157161606,0.182414945640923,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.378511012204916 +"p38 MAPK inhibitor",-0.477466666666667,1.24056178902179,0.00598821677746599,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H520",0.0313670795831991 +"HDAC inhibitor",-0.499666666666667,1.06302712414438,0.139565508463874,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.330969634357187 +"DNA synthesis inhibitor",-0.510666666666667,0.803366280691679,0.930237657776222,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"PARP inhibitor",-0.5204,1.21852016807273,0.00604666594374922,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0313670795831991 +"estrogen receptor agonist",-0.540133333333333,0.719117799476421,0.977295965776543,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352 +"bacterial DNA gyrase inhibitor",-0.6078,0.977415849501707,0.173357113494988,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.368983063357057 +"topoisomerase inhibitor",-0.652066666666667,1.16874563202647,0.0024002044901223,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.0153243825138578 +"MDM inhibitor",-0.750266666666667,1.2734691912066,0.000617053790340294,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1650, H358, HCC15",0.00640193307478055 +"MEK inhibitor",-0.786733333333333,1.08990192656211,0.0393901766978517,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1975, HCC15, HCC44",0.131782638659706 +"MET inhibitor",-0.962,0.942409980543803,0.00106360917134968,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC44, H1299",0.00882795612220233 diff --git a/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_results.csv b/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_results.csv new file mode 100644 index 0000000..1ff0005 --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_results.csv @@ -0,0 +1,1246 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"HCC827","Pearson.est","EGFR inhibitor",-0.31927,-0.792,0.727,1125,0.871,"afatinib, BMS.599626, tyrphostin.AG.1478, osimertinib, pelitinib, lapatinib, PD.168393, WZ8040, PD.153035, erlotinib, TAK.285, icotinib, BIBU.1361",0.138465589140962,0.0599818449923368,FALSE +"HCC827","Pearson.est","Abl kinase inhibitor",-0.31138,-0.773,0.732,1004,0.882,"bosutinib, imatinib, KW.2449, metatinib, tozasertib, bafetinib",0.135488918941608,0.0545314148681803,FALSE +"HCC827","Pearson.est","acetylcholine receptor agonist",-0.278,-0.69,0.837,1262,0.92,"tremorine",0.07727454200674,0.0362121726544447,FALSE +"HCC827","Pearson.est","acetylcholine receptor antagonist",0.46678,1.29,0.197,147,1,"methscopolamine, hyoscyamine",0.705533773838407,0,FALSE +"HCC827","Pearson.est","adenosine receptor antagonist",-0.45639,-1.14,0.276,878,0.735,"MRS.1220, sulmazole, CGS.15943",0.559090917934782,0.133712660915805,FALSE +"HCC827","Pearson.est","adrenergic receptor agonist",-0.35825,-0.884,0.601,1058,0.957,"A61603, buphenine, oxymetazoline, metaraminol, terbutaline, epinephrine, isoxsuprine",0.22112552799726,0.0190880622231565,FALSE +"HCC827","Pearson.est","adrenergic receptor antagonist",0.35699,0.95,0.496,111,0.967,"atipamezole, metoprolol, dihydroergocristine, atenolol......",0.304518323509803,0.0145735259169983,FALSE +"HCC827","Pearson.est","AKT inhibitor",-0.54678,-1.36,0.138,1129,0.56,"GDC.0068, AZD5363, CCT128930, uprosertib, palomid.529, triciribine",0.860120913598763,0.2518119729938,FALSE +"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41805,-1.06,0.392,851,0.785,"alectinib, crizotinib, AZD3463, lorlatinib, NVP.TAE684, GW.788388, CEP.37440",0.406713932979543,0.105130343254747,FALSE +"HCC827","Pearson.est","androgen receptor antagonist",0.28849,0.795,0.672,1032,1,"RU.58841, enzalutamide, nilutamide, flutamide, bicalutamide, cyproterone.acetate",0.172630726946175,0,FALSE +"HCC827","Pearson.est","antioxidant",0.38941,1.02,0.397,30,0.871,"trolox",0.401209493236885,0.0599818449923368,FALSE +"HCC827","Pearson.est","AP inhibitor",-0.46918,-1.15,0.299,958,0.744,"tanshinone.i, GDC.0152, embelin, LCL.161",0.52432881167557,0.128427064454121,FALSE +"HCC827","Pearson.est","ATPase inhibitor",0.71507,1.94,0.0196,219,0.315,"k.strophanthidin, oligomycin.a, digoxin, blebbistatin...., evodiamine, NMS.873",1.70774392864352,0.501689446210399,FALSE +"HCC827","Pearson.est","Aurora kinase inhibitor",-0.30475,-0.77,0.75,1056,0.868,"AMG900, hesperadin, KW.2449, alisertib, ZM.447439, tozasertib, PF.03814735, MLN.8054",0.1249387366083,0.0614802748235081,FALSE +"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.39241,1.06,0.355,94,0.924,"josamycin, radezolid",0.449771646944906,0.0343280287798933,FALSE +"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",-0.29616,-0.75,0.782,1151,0.878,"trovafloxacin, novobiocin",0.106793246940152,0.0565054840938974,FALSE +"HCC827","Pearson.est","BCL inhibitor",0.44678,1.19,0.244,382,0.996,"ABT.737, gossypol, TW.37, obatoclax, venetoclax",0.612610173661271,0.00174066157630127,FALSE +"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",-0.34558,-0.867,0.624,1004,0.938,"bosutinib, imatinib, metatinib, tozasertib, bafetinib",0.204815410317576,0.0277971616209356,FALSE +"HCC827","Pearson.est","benzodiazepine receptor agonist",-0.25005,-0.636,0.876,1160,0.942,"zaleplon, CGS.20625",0.0574958938319193,0.0259490972071227,FALSE +"HCC827","Pearson.est","bromodomain inhibitor",-0.52024,-1.3,0.166,760,0.618,"I.BET151, bromosporine, OTX015, I.BET.762, JQ1....",0.779891911959945,0.209011524911184,FALSE +"HCC827","Pearson.est","calcium channel blocker",0.43959,1.18,0.256,80,0.898,"carboxyamidotriazole, efonidipine.monoethanolate",0.59176003468815,0.0467236633326956,FALSE +"HCC827","Pearson.est","CC chemokine receptor antagonist",-0.33367,-0.835,0.674,1442,0.879,"navarixin",0.17134010346468,0.0560111249262281,FALSE +"HCC827","Pearson.est","CDK inhibitor",-0.43953,-1.11,0.339,1271,0.736,"kenpaullone, PHA.793887, arcyriaflavin.a, alvocidib, AZD5438",0.469800301796918,0.133122185662501,FALSE +"HCC827","Pearson.est","CHK inhibitor",-0.56613,-1.42,0.107,1086,0.507,"SCH.900776, LY2603618, LY2606368",0.97061622231479,0.294992040666664,FALSE +"HCC827","Pearson.est","cyclooxygenase inhibitor",-0.35103,-0.878,0.599,1078,0.942,"acetylsalicylsalicylic.acid, AM.404, FR.122047, aspirin, curcumin, ramifenazone, meloxicam, FK.3311, indoprofen, amfenac",0.222573177610689,0.0259490972071227,FALSE +"HCC827","Pearson.est","cytochrome P450 inhibitor",-0.33267,-0.849,0.637,1299,0.899,"cobicistat",0.19586056766465,0.0462403082667712,FALSE +"HCC827","Pearson.est","DNA alkylating agent",-0.46925,-1.16,0.278,1233,0.755,"dianhydrogalactitol, melphalan, streptozotocin, TH.302, dacarbazine",0.555955204081924,0.122053048370812,FALSE +"HCC827","Pearson.est","DNA inhibitor",-0.2339,-0.577,0.939,1247,0.974,"melphalan, nithiamide, busulfan",0.0273344077338891,0.0114410431213845,FALSE +"HCC827","Pearson.est","DNA methyltransferase inhibitor",-0.57064,-1.42,0.11,1238,0.507,"decitabine, fdcyd, azacitidine",0.958607314841775,0.294992040666664,FALSE +"HCC827","Pearson.est","DNA polymerase inhibitor",0.22566,0.611,0.916,82,1,"menadione",0.0381045263321496,0,FALSE +"HCC827","Pearson.est","DNA synthesis inhibitor",-0.32758,-0.824,0.682,1149,0.858,"CB.10.277, anisomycin, floxuridine, altretamine",0.166215625343521,0.0665127121512946,FALSE +"HCC827","Pearson.est","dopamine receptor antagonist",-0.3289,-0.829,0.681,1179,0.869,"oxiperomide, acetophenazine, amisulpride, isofloxythepin",0.166852888087215,0.0609802235513335,FALSE +"HCC827","Pearson.est","estrogen receptor agonist",-0.33715,-0.853,0.623,1302,0.915,"PPT, estradiol",0.20551195334083,0.0385789059335517,FALSE +"HCC827","Pearson.est","estrogen receptor antagonist",-0.44231,-1.12,0.322,1094,0.746,"toremifene, raloxifene",0.492144128304169,0.127261172527331,FALSE +"HCC827","Pearson.est","FGFR inhibitor",0.42101,1.16,0.269,234,0.848,"erdafitinib, dovitinib, nintedanib, lenvatinib",0.570247719997592,0.0716041477432862,FALSE +"HCC827","Pearson.est","FLT3 inhibitor",0.26592,0.716,0.81,263,1,"GTP.14564, TG.101348, dovitinib, ponatinib, ENMD.2076, tyrphostin.AG.1296",0.0915149811213502,0,FALSE +"HCC827","Pearson.est","glucocorticoid receptor agonist",0.65804,1.77,0.0323,285,0.416,"hydrocortisone, beclomethasone.dipropionate, triamcinolone, halcinonide, dexamethasone.acetate, triamcinolone.acetonide, desonide, deflazacort, flumethasone.pivalate, betamethasone, clobetasol.propionate, ciclesonide, methylprednisolone, rimexolone, fluocinolone.acetonide",1.4907974776689,0.380906669373257,FALSE +"HCC827","Pearson.est","glutamate receptor antagonist",-0.33719,-0.84,0.655,949,0.893,"ACDPP, LY456236, latrepirdine, SIB.1757, MTPG, diazooxonorleucine",0.183758700008217,0.0491485411114536,FALSE +"HCC827","Pearson.est","glycogen synthase kinase inhibitor",-0.65554,-1.67,0.0438,1251,0.499,"LY2090314, kenpaullone, GSK.3.inhibitor.IX, AZD2858",1.3585258894959,0.30189945437661,FALSE +"HCC827","Pearson.est","growth factor receptor inhibitor",0.29285,0.786,0.689,1026,1,"PHA.848125, GSK1904529A, lestaurtinib, danusertib, GW.441756, GSK1838705A, AZD3463",0.161780778092374,0,FALSE +"HCC827","Pearson.est","HCV inhibitor",-0.70672,-1.75,0.0191,1119,0.438,"PSI.7976, daclatasvir, embelin, Ro.9187",1.71896663275227,0.3585258894959,FALSE +"HCC827","Pearson.est","HDAC inhibitor",-0.5877,-1.45,0.0946,1168,0.586,"givinostat, nexturastat.a, dacinostat, M.344, entinostat, romidepsin, panobinostat, R306465, PCI.24781, SB.939, tacedinaline, JNJ.26481585",1.02410886359821,0.232102383981909,FALSE +"HCC827","Pearson.est","histamine receptor antagonist",-0.53699,-1.35,0.142,1145,0.545,"pheniramine, ICI.162846, levocetirizine, tiotidine, ranitidine, terfenadine, tecastemizole, zolantidine, chloropyramine",0.847711655616944,0.263603497723358,FALSE +"HCC827","Pearson.est","HMGCR inhibitor",-0.42054,-1.05,0.405,1211,0.776,"mevastatin, simvastatin",0.392544976785331,0.110138278741812,FALSE +"HCC827","Pearson.est","HSP inhibitor",-0.64668,-1.58,0.0505,1220,0.659,"SNX.2112, tanespimycin, SNX.5422, BIIB021, PU.H71, VER.49009, NVP.AUY922, XL888",1.29670862188134,0.18111458540599,FALSE +"HCC827","Pearson.est","JAK inhibitor",0.2615,0.721,0.797,211,1,"filgotinib, TG.101348, TG.101209, AT.9283, AZ960",0.0985416786038876,0,FALSE +"HCC827","Pearson.est","KIT inhibitor",-0.28871,-0.725,0.795,1009,0.894,"KI.8751, imatinib, vatalanib, sunitinib, tandutinib, telatinib",0.0996328713435297,0.0486624812040823,FALSE +"HCC827","Pearson.est","MDM inhibitor",-0.38271,-0.945,0.531,974,0.913,"CGM097, serdemetan, RITA",0.274905478918531,0.039529222465701,FALSE +"HCC827","Pearson.est","MEK inhibitor",-0.48871,-1.24,0.226,1010,0.611,"AS.703026, arctigenin, AZD8330, cobimetinib, MEK162, PD.184352, trametinib, Ro.4987655, TAK.733, BIX.02188, nobiletin",0.645891560852599,0.213958789757446,FALSE +"HCC827","Pearson.est","MET inhibitor",-0.57206,-1.42,0.124,1017,0.507,"LY2801653, PF.04217903, AMG458, INC.280",0.906578314837765,0.294992040666664,FALSE +"HCC827","Pearson.est","microtubule inhibitor",-0.35501,-0.906,0.561,890,0.94,"estramustine.phosphate, D.64131, cabazitaxel, podophyllotoxin",0.251037138743839,0.0268721464003014,FALSE +"HCC827","Pearson.est","mTOR inhibitor",0.16112,0.433,0.997,299,1,"torin.1, voxtalisib, XL388, PF.04691502, OSI.027, WYE.354, AZD2014, WYE.125132",0.00130484168834428,0,FALSE +"HCC827","Pearson.est","NFkB pathway inhibitor",0.38871,1.05,0.397,42,0.87,"EVP4593, tyloxapol",0.401209493236885,0.0604807473813815,FALSE +"HCC827","Pearson.est","opioid receptor agonist",-0.42886,-1.07,0.377,1396,0.794,"salvinorin.a",0.423658649794207,0.100179497572904,FALSE +"HCC827","Pearson.est","p38 MAPK inhibitor",-0.58324,-1.45,0.0902,1221,0.586,"TAK.715, VX.702, CMPD.1",1.04479346245806,0.232102383981909,FALSE +"HCC827","Pearson.est","PARP inhibitor",-0.58612,-1.45,0.0946,888,0.586,"E7449, AZD2461, talazoparib, olaparib, PJ.34, niraparib",1.02410886359821,0.232102383981909,FALSE +"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.18419,-0.461,0.988,1009,1,"KI.8751, imatinib, vatalanib, sunitinib, tandutinib, telatinib, trapidil",0.00524305541237188,0,FALSE +"HCC827","Pearson.est","phosphatase inhibitor",0.35715,0.94,0.525,82,0.926,"GSK2830371, menadione",0.279840696594043,0.0333890133180656,FALSE +"HCC827","Pearson.est","phosphodiesterase inhibitor",-0.50714,-1.26,0.205,1016,0.6,"cilostamide, papaverine, zardaverine, EMD.53998, GSK256066, YM.976",0.688246138944246,0.221848749616356,FALSE +"HCC827","Pearson.est","PI3K inhibitor",-0.18036,-0.451,0.997,835,0.991,"CUDC.907, YM.201636, LY3023414, GSK2126458, alpelisib, PKI.179, NVP.BEZ235, taselisib, PF.05212384, LY303511, PIK.75, TG.100713, CH5132799, pilaralisib, PI.103",0.00130484168834428,0.00392634551472468,FALSE +"HCC827","Pearson.est","PLK inhibitor",0.25121,0.681,0.835,1086,1,"volasertib, NMS.1286937, GW.843682X, rigosertib, HMN.214, GSK461364, BI.2536",0.0783135245163979,0,FALSE +"HCC827","Pearson.est","potassium channel blocker",-0.59988,-1.51,0.0729,1215,0.646,"oleoylethanolamide, meglitinide",1.13727247168203,0.189767482004916,FALSE +"HCC827","Pearson.est","PPAR receptor agonist",0.32839,0.902,0.539,251,0.955,"fenofibrate, clofibrate, pterostilbene",0.268411234813261,0.0199966284162537,FALSE +"HCC827","Pearson.est","progesterone receptor agonist",0.54686,1.45,0.0891,28,1,"norethindrone, tanaproget",1.05012229596313,0,FALSE +"HCC827","Pearson.est","proteasome inhibitor",-0.7164,-1.83,0.0063,1171,0.429,"carfilzomib, bortezomib, ONX.0914, delanzomib, ixazomib, ixazomib.citrate",2.20065945054642,0.367542707815276,FALSE +"HCC827","Pearson.est","protein synthesis inhibitor",0.23785,0.651,0.901,235,1,"clofoctol, clindamycin.phosphate, harringtonine, florfenicol",0.045275209020937,0,FALSE +"HCC827","Pearson.est","protein tyrosine kinase inhibitor",0.41025,1.09,0.349,98,0.935,"mubritinib, PP.121",0.45717457304082,0.0291883891274822,FALSE +"HCC827","Pearson.est","RAF inhibitor",-0.55186,-1.37,0.136,1226,0.577,"LGX818, CEP.32496, GDC.0879, vemurafenib, dabrafenib",0.866461091629782,0.238824186844269,FALSE +"HCC827","Pearson.est","RET tyrosine kinase inhibitor",-0.50669,-1.27,0.204,802,0.611,"regorafenib, cabozantinib, vandetanib, sunitinib, apatinib",0.690369832574101,0.213958789757446,FALSE +"HCC827","Pearson.est","retinoid receptor agonist",-0.32538,-0.82,0.662,1191,0.844,"tamibarotene, AM.580, CD.437",0.1791420105603,0.073657553374345,FALSE +"HCC827","Pearson.est","ribonucleotide reductase inhibitor",-0.39775,-1.01,0.427,1321,0.831,"fludarabine.phosphate, clofarabine, fludarabine",0.369572124974976,0.080398976215889,FALSE +"HCC827","Pearson.est","serotonin receptor agonist",0.44602,1.22,0.216,216,1,"NAN.190, zolmitriptan, aripiprazole",0.665546248849069,0,FALSE +"HCC827","Pearson.est","serotonin receptor antagonist",0.24134,0.652,0.869,216,1,"SB.200646, pirenperone, aripiprazole",0.0609802235513335,0,FALSE +"HCC827","Pearson.est","sodium channel blocker",0.27448,0.762,0.766,184,1,"cibenzoline, oxcarbazepine, benzethonium",0.115771230367396,0,FALSE +"HCC827","Pearson.est","src inhibitor",-0.25612,-0.64,0.881,1004,0.956,"bosutinib, saracatinib, KX2.391, PP.2",0.0550240915879521,0.0195421077238999,FALSE +"HCC827","Pearson.est","sterol demethylase inhibitor",0.46536,1.27,0.217,239,1,"posaconazole, sulconazole, terconazole, chlormidazole",0.66354026615147,0,FALSE +"HCC827","Pearson.est","TGF beta receptor inhibitor",-0.37028,-0.934,0.524,1107,0.908,"repsox, D.4476, LY2109761",0.280668713016273,0.0419141514789149,FALSE +"HCC827","Pearson.est","thymidylate synthase inhibitor",-0.61255,-1.51,0.0525,1266,0.646,"raltitrexed, carmofur, doxifluridine",1.27984069659404,0.189767482004916,FALSE +"HCC827","Pearson.est","topoisomerase inhibitor",-0.50946,-1.27,0.193,1195,0.611,"amsacrine, etoposide, nemorubicin, irinotecan, rubitecan, SN.38, licochalcone.a, camptothecin, exatecan.mesylate, genz.644282",0.714442690992226,0.213958789757446,FALSE +"HCC827","Pearson.est","tubulin polymerization inhibitor",-0.33859,-0.855,0.623,1039,0.936,"epothilone.d, epothilone.b, plinabulin, mebendazole, fosbretabulin, KX2.391, taltobulin, podophyllotoxin, combretastatin.A.4",0.20551195334083,0.0287241512618947,FALSE +"HCC827","Pearson.est","tyrosine kinase inhibitor",0.19558,0.524,0.974,98,1,"mubritinib, GTP.14564, PP.121",0.0114410431213845,0,FALSE +"HCC827","Pearson.est","VEGFR inhibitor",0.13506,0.372,1,385,0.999,"SAR131675, ZM.306416, dovitinib, axitinib, nintedanib, ENMD.2076, lenvatinib, semaxanib, cediranib, linifanib, pazopanib, motesanib",0,0.000434511774017692,FALSE +"HCC827","Pearson.est","vitamin D receptor agonist",-0.38639,-0.974,0.494,1239,0.879,"calcitriol, ercalcitriol",0.306273051076353,0.0560111249262281,FALSE +"HCC95","Pearson.est","EGFR inhibitor",-0.15561,-0.382,1,944,1,"neratinib, GW.583340, erlotinib, BIBU.1361, OSI.420, WZ8040, lapatinib, CP.724714, AEE788, TAK.285, BIBX.1382, tyrphostin.AG.1478, BMS.599626",0,0,FALSE +"HCC95","Pearson.est","Abl kinase inhibitor",0.26229,0.704,0.807,157,0.884,"ZM.306416, flumatinib, ponatinib",0.0931264652779296,0.0535477349869269,FALSE +"HCC95","Pearson.est","acetylcholine receptor agonist",0.50752,1.35,0.15,3,0.726,"xanomeline",0.823908740944319,0.139063379299906,FALSE +"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.37627,-0.94,0.537,822,0.78,"dicycloverine, hyoscyamine, darifenacin, diphemanil",0.270025714300444,0.10790539730952,FALSE +"HCC95","Pearson.est","adenosine receptor antagonist",0.39695,1.07,0.36,876,0.849,"MRS.1220, SCH.58261, istradefylline, CGS.15943, PSB.1115, theophylline, sulmazole",0.443697499232713,0.0710923097560473,FALSE +"HCC95","Pearson.est","adrenergic receptor agonist",-0.41177,-1.03,0.444,1202,0.831,"methyldopa, buphenine, clenbuterol, terbutaline, metaraminol, epinephrine",0.35261702988538,0.080398976215889,FALSE +"HCC95","Pearson.est","adrenergic receptor antagonist",0.2759,0.759,0.737,99,0.984,"atipamezole, atenolol...., prazosin",0.132532512140949,0.00700490156865849,FALSE +"HCC95","Pearson.est","AKT inhibitor",-0.47841,-1.18,0.272,1237,0.892,"GDC.0068, ONC201, triciribine, uprosertib",0.565431095965801,0.0496351456238769,FALSE +"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41041,-1.01,0.447,771,0.795,"brigatinib, lorlatinib, DMH1, AZD3463, CEP.37440, crizotinib, GW.788388",0.349692476868064,0.0996328713435297,FALSE +"HCC95","Pearson.est","androgen receptor antagonist",-0.57758,-1.44,0.083,949,0.95,"nilutamide, enzalutamide, cyproterone.acetate, bicalutamide",1.08092190762393,0.0222763947111523,FALSE +"HCC95","Pearson.est","antioxidant",0.476,1.28,0.196,146,0.649,"trolox, benfotiamine",0.707743928643524,0.187755303199631,FALSE +"HCC95","Pearson.est","AP inhibitor",0.37948,1.04,0.38,2,0.836,"idronoxil",0.42021640338319,0.0777937225609836,FALSE +"HCC95","Pearson.est","ATPase inhibitor",0.65199,1.74,0.0211,282,0.807,"k.strophanthidin, blebbistatin...., NMS.873, evodiamine, ouabain, thonzonium, digitoxigenin",1.67571754470231,0.0931264652779296,FALSE +"HCC95","Pearson.est","Aurora kinase inhibitor",-0.25637,-0.623,0.902,1290,0.984,"hesperadin, MLN.8054, PF.03814735, tozasertib",0.0447934624580583,0.00700490156865849,FALSE +"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.4343,-1.07,0.379,970,0.859,"valnemulin, azalomycin.b, tedizolid, dirithromycin, azithromycin",0.421360790031928,0.0660068361687577,FALSE +"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",-0.37044,-0.93,0.555,1360,0.76,"lomefloxacin, novobiocin",0.255707016877324,0.119186407719209,FALSE +"HCC95","Pearson.est","BCL inhibitor",0.31602,0.855,0.611,345,0.973,"ABT.737, gossypol, TW.37, navitoclax",0.213958789757446,0.0118871597316481,FALSE +"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.31434,-0.772,0.749,1308,0.89,"imatinib, tozasertib",0.125518182300534,0.0506099933550872,FALSE +"HCC95","Pearson.est","benzodiazepine receptor agonist",-0.30341,-0.752,0.772,965,0.901,"bentazepam, ivermectin, lorazepam, eprinomectin, zaleplon",0.112382699664264,0.045275209020937,FALSE +"HCC95","Pearson.est","bromodomain inhibitor",0.48096,1.32,0.181,316,0.663,"PFI.1, bromosporine, OTX015",0.742321425130815,0.178486471595227,FALSE +"HCC95","Pearson.est","calcium channel blocker",0.26378,0.734,0.75,279,0.882,"efonidipine.monoethanolate, SR.33805, tetrandrine, carboxyamidotriazole",0.1249387366083,0.0545314148681803,FALSE +"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.56687,-1.39,0.111,1063,0.797,"MK.0812, ZK811752, RS.504393, PF.04136309, navarixin",0.954677021213343,0.0985416786038876,FALSE +"HCC95","Pearson.est","CDK inhibitor",-0.32268,-0.802,0.689,996,0.863,"indisulam, BMS.265246, arcyriaflavin.a, JNJ.7706621, BMS.387032, R547, AZD5438, PHA.793887, alvocidib",0.161780778092374,0.0639892042847904,FALSE +"HCC95","Pearson.est","CHK inhibitor",-0.56236,-1.39,0.124,914,0.797,"PF.477736, LY2603618, LY2606368, SB.218078, CHIR.124, SCH.900776",0.906578314837765,0.0985416786038876,FALSE +"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.44585,-1.1,0.338,1146,0.89,"phenazone, acetylsalicylsalicylic.acid, indoprofen, FK.3311, ramifenazone, curcumin, aspirin, amfenac, meloxicam",0.471083299722345,0.0506099933550872,FALSE +"HCC95","Pearson.est","cytochrome P450 inhibitor",0.42249,1.16,0.279,200,0.733,"eplerenone, morin, metyrapone",0.554395796726402,0.134896025358872,FALSE +"HCC95","Pearson.est","DNA alkylating agent",-0.50732,-1.26,0.215,1124,0.87,"cyclophosphamide, melphalan, carboplatin, dianhydrogalactitol, mitomycin.c, dacarbazine",0.667561540084395,0.0604807473813815,FALSE +"HCC95","Pearson.est","DNA inhibitor",-0.62148,-1.52,0.0666,1123,0.947,"valrubicin, tirapazamine, melphalan, carboplatin, sangivamycin, nimorazole, busulfan, nithiamide",1.1765257708297,0.0236500209967266,FALSE +"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.55324,-1.41,0.103,1316,0.941,"fdcyd, azacitidine",0.987162775294828,0.0264103765727431,FALSE +"HCC95","Pearson.est","DNA polymerase inhibitor",-0.31866,-0.803,0.714,1015,0.88,"idoxuridine, famciclovir, trifluridine, foscarnet",0.146301788223826,0.0555173278498314,FALSE +"HCC95","Pearson.est","DNA synthesis inhibitor",-0.40767,-1.01,0.436,1147,0.795,"CB.10.277, cyclocytidine, enocitabine, mitomycin.c, floxuridine, altretamine",0.360513510731414,0.0996328713435297,FALSE +"HCC95","Pearson.est","dopamine receptor antagonist",-0.49299,-1.21,0.266,1070,0.905,"acetophenazine, ziprasidone, lurasidone, domperidone, isofloxythepin, amisulpride, oxiperomide",0.575118363368933,0.0433514207947967,FALSE +"HCC95","Pearson.est","estrogen receptor agonist",-0.42502,-1.05,0.415,1315,0.842,"equol, PPT",0.381951903287907,0.0746879085003505,FALSE +"HCC95","Pearson.est","estrogen receptor antagonist",-0.2251,-0.572,0.941,769,1,"tamoxifen, danazol, clomifene, raloxifene",0.0264103765727431,0,FALSE +"HCC95","Pearson.est","FGFR inhibitor",0.26773,0.746,0.767,1063,0.906,"erdafitinib, PD.173074, nintedanib, orantinib, MK.2461, dovitinib, AZD4547, regorafenib, lucitanib, lenvatinib",0.115204636051019,0.0428718023231869,FALSE +"HCC95","Pearson.est","FLT3 inhibitor",-0.41457,-1.03,0.422,1327,0.831,"sunitinib, tozasertib, pacritinib, tandutinib",0.374687549038326,0.080398976215889,FALSE +"HCC95","Pearson.est","glucocorticoid receptor agonist",0.59776,1.57,0.0742,245,0.869,"deflazacort, prednisolone.hemisuccinate, triamcinolone.acetonide, flumethasone.pivalate, beclomethasone.dipropionate, dexamethasone.acetate, desonide, triamcinolone, betamethasone, ciclesonide, fluocinolone.acetonide, halcinonide, piretanide, rimexolone, hydrocortisone",1.12959609472097,0.0609802235513335,FALSE +"HCC95","Pearson.est","glutamate receptor antagonist",-0.36231,-0.897,0.58,1212,0.798,"tiletamine, CPP, latrepirdine, diazooxonorleucine",0.236572006437063,0.0979971086492706,FALSE +"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.24547,0.646,0.844,308,0.917,"indirubin, TWS.119, CHIR.99021",0.073657553374345,0.0376306643299789,FALSE +"HCC95","Pearson.est","growth factor receptor inhibitor",0.29632,0.786,0.728,1021,0.992,"GSK1904529A, PHA.848125, lestaurtinib, danusertib, AZD3463, GSK1838705A, GW.441756",0.137868620686963,0.00348832784582135,FALSE +"HCC95","Pearson.est","HCV inhibitor",-0.54442,-1.34,0.149,1109,0.742,"PSI.7976, embelin, Ro.9187, daclatasvir",0.826813731587726,0.129596094720973,FALSE +"HCC95","Pearson.est","HDAC inhibitor",-0.27388,-0.684,0.835,1000,0.936,"PCI.24781, chidamide, romidepsin, M.344, dacinostat, tacedinaline, SB.939, JNJ.26481585, vorinostat",0.0783135245163979,0.0287241512618947,FALSE +"HCC95","Pearson.est","histamine receptor antagonist",-0.42989,-1.08,0.364,982,0.868,"nizatidine, lafutidine, tecastemizole, levocetirizine, astemizole, tiotidine, terfenadine, chloropyramine, zolantidine",0.438898616350944,0.0614802748235081,FALSE +"HCC95","Pearson.est","HMGCR inhibitor",0.30652,0.835,0.653,1006,0.954,"lovastatin, atorvastatin, pitavastatin, fluvastatin, simvastatin, mevastatin",0.185086818724926,0.0204516252959049,FALSE +"HCC95","Pearson.est","HSP inhibitor",-0.19962,-0.491,0.985,766,1,"SNX.2112, BIIB021, XL888, tanespimycin, NVP.AUY922, guanidine, PU.H71, VER.49009",0.00656376950238827,0,FALSE +"HCC95","Pearson.est","JAK inhibitor",-0.38069,-0.941,0.535,1355,0.798,"LY2784544, atiprimod, tozasertib, pacritinib",0.271646217978772,0.0979971086492706,FALSE +"HCC95","Pearson.est","KIT inhibitor",-0.34966,-0.853,0.631,1308,0.855,"imatinib, sunitinib, tandutinib",0.199970640755866,0.0680338852718274,FALSE +"HCC95","Pearson.est","MDM inhibitor",-0.29094,-0.715,0.819,1048,0.916,"idasanutlin, nutlin.3",0.0867160982395816,0.0381045263321496,FALSE +"HCC95","Pearson.est","MEK inhibitor",-0.50416,-1.24,0.229,1041,0.87,"arctigenin, TAK.733, PD.198306, nobiletin, Ro.4987655, AS.703026, cobimetinib, MEK162, BIX.02188, PD.98059, trametinib, PD.0325901",0.640164517660112,0.0604807473813815,FALSE +"HCC95","Pearson.est","MET inhibitor",-0.60191,-1.49,0.0774,903,0.892,"LY2801653, NVP.BVU972, INC.280, PF.04217903, AMG458",1.11125903931711,0.0496351456238769,FALSE +"HCC95","Pearson.est","microtubule inhibitor",0.28283,0.754,0.741,27,0.94,"cytochalasin.b",0.130181792020672,0.0268721464003014,FALSE +"HCC95","Pearson.est","mTOR inhibitor",-0.38762,-0.969,0.499,1088,0.831,"NVP.BEZ235, GSK2126458, AZD8055, PP242, GDC.0980, LY303511, sirolimus, ku.0063794, PI.103",0.30189945437661,0.080398976215889,FALSE +"HCC95","Pearson.est","NFkB pathway inhibitor",-0.38194,-0.943,0.526,1242,0.815,"parthenolide...., betulinic.acid, bortezomib, curcumin",0.279014255846261,0.0888423912600234,FALSE +"HCC95","Pearson.est","opioid receptor agonist",-0.40155,-1.01,0.438,1189,0.795,"BW.180C, salvinorin.a",0.3585258894959,0.0996328713435297,FALSE +"HCC95","Pearson.est","p38 MAPK inhibitor",-0.64469,-1.59,0.0487,929,0.848,"CMPD.1, SB.239063, SB.242235, talmapimod, skepinone.l, VX.702, TAK.715",1.31247103878537,0.0716041477432862,FALSE +"HCC95","Pearson.est","PARP inhibitor",-0.42941,-1.08,0.357,1215,0.868,"PJ.34, niraparib, olaparib",0.447331783887807,0.0614802748235081,FALSE +"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.38538,-0.961,0.502,1308,0.801,"imatinib, sunitinib, trapidil, tandutinib",0.299296282854981,0.0963674839157623,FALSE +"HCC95","Pearson.est","phosphatase inhibitor",0.55023,1.5,0.108,166,0.743,"GSK2830371, menadione, CID.5458317, bis.maltolato.oxovanadium.IV.",0.96657624451305,0.129011186239425,FALSE +"HCC95","Pearson.est","phosphodiesterase inhibitor",0.31494,0.855,0.59,8,0.973,"avanafil",0.229147988357856,0.0118871597316481,FALSE +"HCC95","Pearson.est","PI3K inhibitor",-0.38592,-0.961,0.534,1088,0.801,"NVP.BEZ235, pilaralisib, GSK2126458, PIK.75, alpelisib, taselisib, GDC.0980, LY303511, TG.100713, PI.103, CH5132799",0.272458742971444,0.0963674839157623,FALSE +"HCC95","Pearson.est","PLK inhibitor",-0.4512,-1.11,0.346,753,0.903,"HMN.214, NMS.1286937, GW.843682X, GSK461364, BI.2536",0.460923901207223,0.0443122496864942,FALSE +"HCC95","Pearson.est","potassium channel blocker",-0.55968,-1.38,0.123,1217,0.749,"meglitinide, oleoylethanolamide",0.910094888560602,0.125518182300534,FALSE +"HCC95","Pearson.est","PPAR receptor agonist",0.3594,0.956,0.478,140,0.954,"pterostilbene, fenofibrate",0.320572103387881,0.0204516252959049,FALSE +"HCC95","Pearson.est","progesterone receptor agonist",0.53604,1.48,0.112,44,0.595,"norethindrone, tanaproget",0.950781977329818,0.22548303427145,FALSE +"HCC95","Pearson.est","proteasome inhibitor",-0.69492,-1.71,0.0155,1028,0.568,"MG.132, ixazomib.citrate, ONX.0914, delanzomib, carfilzomib, bortezomib, ixazomib",1.80966830182971,0.245651664288981,FALSE +"HCC95","Pearson.est","protein synthesis inhibitor",0.22711,0.62,0.892,1123,0.905,"clindamycin.phosphate, clofoctol, methacycline, harringtonine, cycloheximide, azomycin..2.nitroimidazole., chloramphenicol.palmitate, anguidine, florfenicol, mercaptopurine, tedizolid.phosphate, emetine, thiostrepton, puromycin, brefeldin.a, bruceantin, homoharringtonine",0.0496351456238769,0.0433514207947967,FALSE +"HCC95","Pearson.est","protein tyrosine kinase inhibitor",0.4416,1.22,0.197,42,0.687,"PP.121, mubritinib",0.705533773838407,0.16304326294045,FALSE +"HCC95","Pearson.est","RAF inhibitor",-0.44802,-1.12,0.323,1075,0.919,"LGX818, SB.590885, CEP.32496, dabrafenib, vemurafenib, AZ.628",0.490797477668897,0.0366844886138887,FALSE +"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.53408,-1.33,0.159,1327,0.714,"sunitinib, apatinib",0.798602875679548,0.146301788223826,FALSE +"HCC95","Pearson.est","retinoid receptor agonist",-0.38123,-0.938,0.52,1066,0.764,"adapalene, bexarotene, tamibarotene, AM.580, CD.437",0.283996656365201,0.11690664142431,FALSE +"HCC95","Pearson.est","ribonucleotide reductase inhibitor",-0.39381,-0.985,0.471,961,0.823,"cladribine, clofarabine, fludarabine, fludarabine.phosphate",0.326979092871104,0.0846001647877302,FALSE +"HCC95","Pearson.est","serotonin receptor agonist",-0.33844,-0.828,0.675,814,0.858,"ipsapirone, aripiprazole, zolmitriptan",0.170696227168975,0.0665127121512946,FALSE +"HCC95","Pearson.est","serotonin receptor antagonist",-0.47115,-1.18,0.266,985,0.892,"sertindole, aripiprazole, ziprasidone, SB.228357, lurasidone, SB.216641, RS.16566",0.575118363368933,0.0496351456238769,FALSE +"HCC95","Pearson.est","sodium channel blocker",-0.34142,-0.851,0.645,1149,0.84,"triamterene, brivaracetam, ajmaline, butamben, lappaconite",0.190440285364732,0.0757207139381184,FALSE +"HCC95","Pearson.est","src inhibitor",0.33204,0.873,0.571,124,1,"ZM.306416, TG.100572, masitinib",0.243363891754152,0,FALSE +"HCC95","Pearson.est","sterol demethylase inhibitor",-0.46713,-1.15,0.296,1273,0.927,"ketoconazole, lanoconazole",0.528708288941061,0.0329202658555029,FALSE +"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.4514,-1.12,0.345,1103,0.919,"repsox, D.4476, LY2109761",0.462180904926726,0.0366844886138887,FALSE +"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.72545,-1.79,0.0088,1181,0.609,"raltitrexed, trifluridine, carmofur, doxifluridine",2.05551732784983,0.215382707367125,FALSE +"HCC95","Pearson.est","topoisomerase inhibitor",-0.42169,-1.05,0.411,859,0.842,"dexrazoxane, etoposide, rubitecan, beta.lapachone, idarubicin, camptothecin, amonafide, valrubicin, SN.38, topotecan, irinotecan, amsacrine, genz.644282, licochalcone.a, exatecan.mesylate",0.386158178123931,0.0746879085003505,FALSE +"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.11291,-0.279,1,980,1,"combretastatin.A.4, epothilone.b, KX2.391, oxibendazole, mebendazole",0,0,FALSE +"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.29583,-0.731,0.795,1327,0.912,"sunitinib, AMG.208, apatinib, BMS.599626",0.0996328713435297,0.0400051616715838,FALSE +"HCC95","Pearson.est","VEGFR inhibitor",-0.17047,-0.418,0.994,900,1,"vatalanib, linifanib, cabozantinib, regorafenib, ENMD.2076, foretinib, golvatinib, lucitanib, tivozanib, OSI.930, lenvatinib, AEE788, MGCD.265, sunitinib",0.00261361560268669,0,FALSE +"HCC95","Pearson.est","vitamin D receptor agonist",-0.5472,-1.36,0.152,1406,0.74,"maxacalcitol, ercalcitriol",0.818156412055227,0.130768280269024,FALSE +"H1650","Pearson.est","EGFR inhibitor",-0.39467,-0.983,0.48,992,0.906,"canertinib, CNX.2006, WZ.4002, afatinib, gefitinib, osimertinib, ARRY.334543, CGP.52411, tyrphostin.AG.494, OSI.420, TAK.285, BMS.599626, PD.153035, BIBX.1382, pelitinib, icotinib, rociletinib, tyrphostin.AG.1478, vandetanib, erlotinib, PD.168393, WZ8040, BIBU.1361",0.318758762624413,0.0428718023231869,FALSE +"H1650","Pearson.est","Abl kinase inhibitor",0.29248,0.778,0.726,1028,1,"GZD824, ponatinib, KW.2449, bafetinib, imatinib, tozasertib, flumatinib, dasatinib, metatinib, ZM.306416, bosutinib, nilotinib",0.139063379299906,0,FALSE +"H1650","Pearson.est","acetylcholine receptor agonist",0.53351,1.43,0.126,53,0.42,"xanomeline",0.899629454882437,0.3767507096021,FALSE +"H1650","Pearson.est","acetylcholine receptor antagonist",-0.26443,-0.647,0.878,938,1,"darifenacin, iododexetimide, diphemanil",0.0565054840938974,0,FALSE +"H1650","Pearson.est","adenosine receptor antagonist",-0.33444,-0.82,0.68,1192,1,"sulmazole, istradefylline",0.167491087293764,0,FALSE +"H1650","Pearson.est","adrenergic receptor agonist",-0.32188,-0.806,0.666,1060,1,"isoxsuprine, xylazine, oxymetazoline, epinephrine, isoetharine",0.176525770829699,0,FALSE +"H1650","Pearson.est","adrenergic receptor antagonist",0.36487,0.952,0.479,172,0.892,"atenolol......, dihydroergocristine, naftidrofuryl, idazoxan",0.319664486585437,0.0496351456238769,FALSE +"H1650","Pearson.est","AKT inhibitor",-0.3664,-0.908,0.555,1007,0.967,"GSK2110183, triciribine, palomid.529, AZD5363, CCT128930, AT7867",0.255707016877324,0.0145735259169983,FALSE +"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.21424,-0.532,0.963,1019,0.983,"NVP.TAE684, GW.788388, lorlatinib, AP26113",0.0163737128754655,0.00744648216786438,FALSE +"H1650","Pearson.est","androgen receptor antagonist",-0.23792,-0.593,0.929,1251,1,"RU.58841",0.0319842860063582,0,FALSE +"H1650","Pearson.est","antioxidant",-0.43411,-1.08,0.381,1077,1,"benfotiamine, mesna, rutin",0.419075024324381,0,FALSE +"H1650","Pearson.est","AP inhibitor",-0.6377,-1.55,0.0479,1326,0.489,"embelin, tanshinone.i, GDC.0152",1.31966448658544,0.31069114087638,FALSE +"H1650","Pearson.est","ATPase inhibitor",0.71133,1.9,0.0147,37,0.21,"k.strophanthidin, evodiamine, digoxin, NMS.873",1.83268266525182,0.677780705266081,TRUE +"H1650","Pearson.est","Aurora kinase inhibitor",0.25774,0.692,0.835,325,1,"CCT137690, CCT129202, PHA.680632, aurora.a.inhibitor.i, danusertib, barasertib.HQPA, barasertib, AMG900",0.0783135245163979,0,FALSE +"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.28305,0.75,0.753,279,0.999,"josamycin, azalomycin.b, azithromycin",0.123205023799299,0.000434511774017692,FALSE +"H1650","Pearson.est","bacterial DNA gyrase inhibitor",-0.32318,-0.818,0.687,934,1,"trovafloxacin, sarafloxacin, novobiocin, finafloxacin",0.16304326294045,0,FALSE +"H1650","Pearson.est","BCL inhibitor",0.50357,1.33,0.159,320,0.536,"venetoclax, gossypol, TW.37, oridonin",0.798602875679548,0.27083521030723,FALSE +"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.29207,0.765,0.739,1028,1,"GZD824, ponatinib, bafetinib, imatinib, tozasertib, flumatinib, dasatinib, metatinib, bosutinib, nilotinib",0.131355561605174,0,FALSE +"H1650","Pearson.est","benzodiazepine receptor agonist",-0.27203,-0.671,0.841,1112,1,"zaleplon, CGS.20625, lorazepam",0.0752040042020878,0,FALSE +"H1650","Pearson.est","bromodomain inhibitor",0.33178,0.9,0.541,205,0.961,"PFI.1, I.BET.762",0.266802734893431,0.0172766123314547,FALSE +"H1650","Pearson.est","calcium channel blocker",0.25784,0.689,0.842,171,0.984,"carboxyamidotriazole, SKF.96365",0.0746879085003505,0.00700490156865849,FALSE +"H1650","Pearson.est","CC chemokine receptor antagonist",-0.43515,-1.07,0.37,1197,1,"MK.0812, RS.504393, navarixin",0.431798275933005,0,FALSE +"H1650","Pearson.est","CDK inhibitor",0.41326,1.13,0.295,419,0.702,"PHA.848125, abemaciclib, indisulam, dinaciclib, AT.7519, BMS.387032, JNJ.7706621, alvocidib, P276.00, palbociclib, PHA.793887",0.530177984021837,0.153662887870195,FALSE +"H1650","Pearson.est","CHK inhibitor",-0.39898,-0.986,0.476,888,0.935,"LY2606368, CHIR.124, SCH.900776, AZD7762",0.322393047279507,0.0291883891274822,FALSE +"H1650","Pearson.est","cyclooxygenase inhibitor",-0.41974,-1.03,0.427,1092,0.992,"acetylsalicylsalicylic.acid, ketoprofen, amfenac, curcumin, tryptanthrin, indoprofen, pterostilbene, FR.122047, metoxibutropate, naproxen",0.369572124974976,0.00348832784582135,FALSE +"H1650","Pearson.est","cytochrome P450 inhibitor",-0.467,-1.16,0.293,1246,0.905,"cobicistat, itraconazole",0.533132379645891,0.0433514207947967,FALSE +"H1650","Pearson.est","DNA alkylating agent",0.30347,0.816,0.66,257,1,"carmustine, satraplatin, estramustine, mitomycin.c",0.180456064458131,0,FALSE +"H1650","Pearson.est","DNA inhibitor",0.26448,0.684,0.852,403,0.956,"carmustine, mechlorethamine, chlorambucil, sangivamycin, pibenzimol, bendamustine, teroxirone, carboplatin",0.0695604052332999,0.0195421077238999,FALSE +"H1650","Pearson.est","DNA methyltransferase inhibitor",-0.30344,-0.749,0.775,1214,1,"RG108, azacitidine",0.11069829749369,0,FALSE +"H1650","Pearson.est","DNA polymerase inhibitor",-0.532,-1.31,0.149,1034,0.664,"adefovir.dipivoxil, famciclovir, cephalomannine, cidofovir",0.826813731587726,0.177831920631982,FALSE +"H1650","Pearson.est","DNA synthesis inhibitor",-0.31575,-0.792,0.709,1359,1,"CB.10.277, estramustine.phosphate",0.149353764816933,0,FALSE +"H1650","Pearson.est","dopamine receptor antagonist",-0.5326,-1.32,0.173,1047,0.693,"domperidone, UH.232...., ziprasidone, raclopride, mesoridazine, amisulpride, acetophenazine, nemonapride, oxiperomide, remoxipride",0.761953896871205,0.159266765388193,FALSE +"H1650","Pearson.est","estrogen receptor agonist",-0.29227,-0.713,0.784,1223,1,"estradiol, PPT",0.105683937315562,0,FALSE +"H1650","Pearson.est","estrogen receptor antagonist",-0.46631,-1.16,0.275,1147,0.905,"raloxifene, fulvestrant",0.560667306169737,0.0433514207947967,FALSE +"H1650","Pearson.est","FGFR inhibitor",0.54992,1.46,0.0955,123,0.422,"dovitinib, nintedanib, erdafitinib, regorafenib, lenvatinib",1.01999662841625,0.374687549038326,FALSE +"H1650","Pearson.est","FLT3 inhibitor",0.24871,0.639,0.887,445,0.946,"dovitinib, tyrphostin.AG.1296, sorafenib, TG.101348, gilteritinib, ponatinib, KW.2449",0.0520763801682736,0.0241088635982073,FALSE +"H1650","Pearson.est","glucocorticoid receptor agonist",-0.2338,-0.576,0.942,993,0.977,"clobetasol.propionate, triamcinolone, triamcinolone.acetonide, flumethasone.pivalate, piretanide, rimexolone, dexamethasone.acetate, difluprednate, fludroxycortide, prednisolone.acetate",0.0259490972071227,0.0101054362812269,FALSE +"H1650","Pearson.est","glutamate receptor antagonist",-0.29826,-0.753,0.755,1046,1,"ACDPP, MTPG, CPP, latrepirdine, SIB.1757",0.122053048370812,0,FALSE +"H1650","Pearson.est","glycogen synthase kinase inhibitor",-0.53822,-1.33,0.156,1319,0.728,"kenpaullone, LY2090314",0.806875401645538,0.137868620686963,FALSE +"H1650","Pearson.est","growth factor receptor inhibitor",0.682,1.84,0.0339,246,0.202,"PHA.848125, GSK1838705A, danusertib",1.46980030179692,0.694648630553376,TRUE +"H1650","Pearson.est","HCV inhibitor",-0.79713,-2,0.00331,1310,0.0766,"Ro.9187, PSI.7976, embelin, narlaprevir",2.48017200622428,1.1157712303674,TRUE +"H1650","Pearson.est","HDAC inhibitor",-0.50496,-1.25,0.197,1146,0.772,"SB.939, nexturastat.a, ACY.1215, RGFP966, tacedinaline, mocetinostat, romidepsin, entinostat, JNJ.26481585, RG2833",0.705533773838407,0.112382699664264,FALSE +"H1650","Pearson.est","histamine receptor antagonist",-0.57543,-1.45,0.103,975,0.536,"terfenadine, pheniramine, ranitidine, levocetirizine, astemizole, cimetidine, famotidine, BF2.649, tiotidine, lafutidine, ICI.162846, tecastemizole, chloropyramine",0.987162775294828,0.27083521030723,FALSE +"H1650","Pearson.est","HMGCR inhibitor",-0.77928,-1.97,0,1245,0.0528,"mevastatin, atorvastatin, fluvastatin, pitavastatin, simvastatin",Inf,1.27736607746619,TRUE +"H1650","Pearson.est","HSP inhibitor",-0.39599,-0.97,0.499,964,0.9,"BIIB021, NVP.AUY922, XL888, KW.2478, VER.49009, guanidine",0.30189945437661,0.0457574905606751,FALSE +"H1650","Pearson.est","JAK inhibitor",-0.24908,-0.63,0.892,1028,1,"PRT062070, LY2784544, pacritinib, atiprimod",0.0496351456238769,0,FALSE +"H1650","Pearson.est","KIT inhibitor",-0.31894,-0.783,0.733,1347,1,"midostaurin, vatalanib, telatinib",0.134896025358872,0,FALSE +"H1650","Pearson.est","MDM inhibitor",-0.69778,-1.76,0.0141,1355,0.198,"CGM097, RITA",1.85078088734462,0.703334809738469,TRUE +"H1650","Pearson.est","MEK inhibitor",-0.61198,-1.5,0.0792,1059,0.541,"refametinib, PD.198306, PD.0325901, BIX.02188, MEK162, U.0126, PD.318088, Ro.4987655, AZD8330, PD.184352, TAK.733",1.10127481841051,0.266802734893431,FALSE +"H1650","Pearson.est","MET inhibitor",-0.42347,-1.05,0.392,1224,1,"PF.04217903",0.406713932979543,0,FALSE +"H1650","Pearson.est","microtubule inhibitor",0.37545,0.999,0.464,118,0.833,"D.64131, vinblastine, vinflunine",0.333482019445119,0.0793549985932124,FALSE +"H1650","Pearson.est","mTOR inhibitor",-0.23404,-0.582,0.932,1143,0.993,"palomid.529, XL388, deforolimus, torin.2, PF.05212384, sirolimus",0.0305840876460186,0.00305075150461883,FALSE +"H1650","Pearson.est","NFkB pathway inhibitor",-0.42049,-1.04,0.404,1129,1,"Ro.106.9920, bortezomib, curcumin, parthenolide...., BAY.11.7085",0.393618634889395,0,FALSE +"H1650","Pearson.est","opioid receptor agonist",-0.3078,-0.761,0.743,1280,1,"ADL5859",0.129011186239425,0,FALSE +"H1650","Pearson.est","p38 MAPK inhibitor",-0.41625,-1.02,0.431,1121,0.971,"skepinone.l, TAK.715, CMPD.1, VX.702",0.365522729839268,0.0127807700919951,FALSE +"H1650","Pearson.est","PARP inhibitor",-0.301,-0.747,0.784,1205,0.984,"AZD2461, E7449",0.105683937315562,0.00700490156865849,FALSE +"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.3129,0.838,0.645,123,1,"dovitinib, nintedanib, regorafenib, pazopanib, lenvatinib",0.190440285364732,0,FALSE +"H1650","Pearson.est","phosphatase inhibitor",0.37889,1.02,0.405,299,0.835,"GSK2830371, sodium.stibogluconate, AS.1949490, mycophenolic.acid, CID.5458317",0.392544976785331,0.0783135245163979,FALSE +"H1650","Pearson.est","phosphodiesterase inhibitor",-0.41092,-1.01,0.436,1364,0.916,"GSK256066, papaverine",0.360513510731414,0.0381045263321496,FALSE +"H1650","Pearson.est","PI3K inhibitor",0.20039,0.525,0.965,87,0.97,"idelalisib, buparlisib, alpelisib",0.0154726866562074,0.0132282657337552,FALSE +"H1650","Pearson.est","PLK inhibitor",0.7847,2.1,0.011,247,0.0862,"volasertib, NMS.1286937, GW.843682X, BI.2536, HMN.214, rigosertib",1.95860731484178,1.06449273417529,TRUE +"H1650","Pearson.est","potassium channel blocker",-0.64346,-1.6,0.0456,1116,0.443,"mepivacaine, oleoylethanolamide, meglitinide",1.34103515733556,0.35359627377693,FALSE +"H1650","Pearson.est","PPAR receptor agonist",-0.71834,-1.79,0.0176,1163,0.21,"fenofibrate, S26948, pterostilbene, GW.501516, oleoylethanolamide",1.75448733218585,0.677780705266081,TRUE +"H1650","Pearson.est","progesterone receptor agonist",-0.17936,-0.436,0.989,951,0.993,"tanaproget, melengestrol.acetate, norgestrel",0.0048037084028206,0.00305075150461883,FALSE +"H1650","Pearson.est","proteasome inhibitor",-0.56283,-1.43,0.109,929,0.529,"carfilzomib, delanzomib, ixazomib, bortezomib, oprozomib, ixazomib.citrate, ONX.0914",0.962573502059376,0.276544327964814,FALSE +"H1650","Pearson.est","protein synthesis inhibitor",0.55909,1.48,0.0899,307,0.443,"clofoctol, harringtonine, tedizolid.phosphate, homoharringtonine, anguidine, bruceantin, thiostrepton, puromycin, chloramphenicol.palmitate",1.04624030826677,0.35359627377693,FALSE +"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.44158,1.15,0.296,220,0.715,"PP.121, mubritinib, tyrphostin.A9, CP.724714",0.528708288941061,0.145693958198919,FALSE +"H1650","Pearson.est","RAF inhibitor",0.41194,1.11,0.316,322,0.696,"SB.590885, regorafenib, PLX.4720, sorafenib",0.500312917381596,0.157390760389438,FALSE +"H1650","Pearson.est","RET tyrosine kinase inhibitor",-0.41081,-1.01,0.443,1296,0.916,"apatinib, vandetanib",0.35359627377693,0.0381045263321496,FALSE +"H1650","Pearson.est","retinoid receptor agonist",0.64234,1.68,0.0386,208,0.283,"adarotene, fenretinide, adapalene",1.41341269532825,0.54821356447571,FALSE +"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.43399,1.16,0.266,189,0.754,"pentostatin, cytarabine, hydroxyurea",0.575118363368933,0.122628654130226,FALSE +"H1650","Pearson.est","serotonin receptor agonist",0.43914,1.18,0.235,89,0.776,"zolmitriptan, pardoprunox",0.628932137728264,0.110138278741812,FALSE +"H1650","Pearson.est","serotonin receptor antagonist",0.23899,0.645,0.876,175,0.971,"SB.200646, pirenperone, lurasidone",0.0574958938319193,0.0127807700919951,FALSE +"H1650","Pearson.est","sodium channel blocker",-0.34649,-0.867,0.609,1108,1,"A.803467, mepivacaine, mexiletine, quinidine",0.215382707367125,0,FALSE +"H1650","Pearson.est","src inhibitor",-0.24392,-0.6,0.932,351,1,"masitinib, KX2.391, saracatinib, TG.100572, dasatinib, ZM.306416, PP.1, bosutinib, PP.2",0.0305840876460186,0,FALSE +"H1650","Pearson.est","sterol demethylase inhibitor",0.27387,0.743,0.784,342,0.973,"chlormidazole, sulconazole, posaconazole",0.105683937315562,0.0118871597316481,FALSE +"H1650","Pearson.est","TGF beta receptor inhibitor",-0.38097,-0.935,0.514,915,0.941,"repsox, SB.431542, D.4476",0.289036881004724,0.0264103765727431,FALSE +"H1650","Pearson.est","thymidylate synthase inhibitor",0.59955,1.61,0.0463,533,0.315,"ftorafur, carmofur, raltitrexed, capecitabine, doxifluridine",1.33441900898205,0.501689446210399,FALSE +"H1650","Pearson.est","topoisomerase inhibitor",-0.24579,-0.598,0.911,1031,1,"amonafide, TAS.103, rubitecan, idarubicin, licochalcone.a, fleroxacin, beta.lapachone, teniposide, voreloxin, etoposide, camptothecin",0.0404816230270017,0,FALSE +"H1650","Pearson.est","tubulin polymerization inhibitor",0.61926,1.68,0.0477,427,0.283,"vindesine, oxibendazole, fenbendazole, vinblastine, docetaxel, vinorelbine, paclitaxel, verubulin, ABT.751, vincristine, BNC105, dolastatin.10, taltobulin, fosbretabulin, nocodazole, parbendazole, epothilone.b, mebendazole, KX2.391, CYT.997, albendazole",1.32148162095989,0.54821356447571,FALSE +"H1650","Pearson.est","tyrosine kinase inhibitor",0.325,0.861,0.587,71,1,"PP.121, tivantinib, regorafenib, mubritinib",0.231361898752386,0,FALSE +"H1650","Pearson.est","VEGFR inhibitor",0.23408,0.625,0.918,123,0.93,"dovitinib, nintedanib, regorafenib, pazopanib, SAR131675, lenvatinib",0.0371573187987575,0.0315170514460649,FALSE +"H1650","Pearson.est","vitamin D receptor agonist",-0.60859,-1.48,0.085,1167,0.523,"tacalcitol, calcitriol, paricalcitol, ercalcitriol",1.07058107428571,0.281498311132726,FALSE +"H1975","Pearson.est","EGFR inhibitor",0.30784,0.791,0.728,377,0.94,"neratinib, AEE788, tucatinib, GW.583340, CP.724714, lapatinib, OSI.420, CUDC.101, BMS.599626, dacomitinib, PD.153035, dovitinib, TAK.285",0.137868620686963,0.0268721464003014,FALSE +"H1975","Pearson.est","Abl kinase inhibitor",-0.7007,-1.8,0.0121,1341,0.13,"flumatinib, GZD824, KW.2449, ponatinib, dasatinib",1.91721462968355,0.886056647693163,TRUE +"H1975","Pearson.est","acetylcholine receptor agonist",0.29498,0.762,0.751,341,0.942,"pilocarpine, tremorine, oxiracetam",0.124360062995832,0.0259490972071227,FALSE +"H1975","Pearson.est","acetylcholine receptor antagonist",0.74434,1.88,0.00524,258,0.121,"diphemanil, darifenacin, hyoscyamine, dicycloverine",2.28066871301627,0.91721462968355,TRUE +"H1975","Pearson.est","adenosine receptor antagonist",0.3074,0.798,0.66,248,0.979,"CGS.15943, PSB.1115",0.180456064458131,0.00921730819686218,FALSE +"H1975","Pearson.est","adrenergic receptor agonist",0.30757,0.786,0.695,77,0.925,"lidamidine, methyldopa",0.158015195409886,0.0338582672609674,FALSE +"H1975","Pearson.est","adrenergic receptor antagonist",0.37889,0.969,0.494,295,0.924,"RS.17053, idazoxan, prazosin, carvedilol, vincamine, levobunolol",0.306273051076353,0.0343280287798933,FALSE +"H1975","Pearson.est","AKT inhibitor",0.28941,0.731,0.783,156,0.946,"uprosertib, triciribine, A.674563",0.106238237942057,0.0241088635982073,FALSE +"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.23109,-0.603,0.92,1144,0.948,"alectinib, brigatinib, lorlatinib, AP26113",0.0362121726544447,0.0231916626619338,FALSE +"H1975","Pearson.est","androgen receptor antagonist",0.52762,1.34,0.165,627,0.549,"cyproterone.acetate, enzalutamide, flutamide, nilutamide, bicalutamide",0.782516055786094,0.260427655549908,FALSE +"H1975","Pearson.est","antioxidant",-0.78841,-2.07,0.00231,1367,0.0421,"trolox, mesna, benfotiamine",2.63638802010786,1.37571790416433,TRUE +"H1975","Pearson.est","AP inhibitor",0.27155,0.69,0.807,393,0.939,"tanshinone.i, LCL.161",0.0931264652779296,0.0273344077338891,FALSE +"H1975","Pearson.est","ATPase inhibitor",-0.36236,-0.954,0.487,1356,0.836,"k.strophanthidin, oligomycin.a",0.312471038785366,0.0777937225609836,FALSE +"H1975","Pearson.est","Aurora kinase inhibitor",-0.6042,-1.64,0.0641,1105,0.221,"ZM.447439, TAK.901, MLN.8054, CCT129202, hesperadin, AMG900, MK.8745, barasertib, barasertib.HQPA, alisertib, KW.2449, SNS.314, GSK1070916, CYC116, AT.9283",1.19314197048118,0.655607726314889,FALSE +"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.55257,1.39,0.13,153,0.568,"azithromycin, azalomycin.b, dirithromycin",0.886056647693163,0.245651664288981,FALSE +"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.51387,-1.36,0.149,1388,0.421,"novobiocin, finafloxacin",0.826813731587726,0.375717904164332,FALSE +"H1975","Pearson.est","BCL inhibitor",-0.32569,-0.847,0.633,469,0.877,"obatoclax, HA14.1, oridonin, venetoclax, navitoclax, ABT.737, TW.37, gossypol",0.198596289982645,0.0570004066339595,FALSE +"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.70947,-1.96,0.00442,1341,0.0748,"flumatinib, GZD824, ponatinib, dasatinib",2.35457773065091,1.12609840213554,TRUE +"H1975","Pearson.est","benzodiazepine receptor agonist",0.2381,0.611,0.895,635,1,"indiplon, zaleplon, ZK.93423, temazepam, eprinomectin, piperazine, nefiracetam, CL.218872, bentazepam",0.048176964684088,0,FALSE +"H1975","Pearson.est","bromodomain inhibitor",0.39228,1,0.442,93,0.921,"JQ1....",0.354577730650908,0.0357403698031511,FALSE +"H1975","Pearson.est","calcium channel blocker",0.43051,1.1,0.326,219,0.799,"fendiline, tetrandrine, SKF.96365",0.486782399932061,0.0974532206860086,FALSE +"H1975","Pearson.est","CC chemokine receptor antagonist",0.44924,1.16,0.28,563,0.74,"PF.04136309, MK.0812, ZK811752, navarixin, SB.225002, RS.504393",0.552841968657781,0.130768280269024,FALSE +"H1975","Pearson.est","CDK inhibitor",0.36864,0.927,0.548,362,0.954,"BMS.387032, arcyriaflavin.a, JNJ.7706621, PHA.793887, AZD5438, kenpaullone, dinaciclib, alvocidib, CR8..R., BMS.265246",0.261219441515631,0.0204516252959049,FALSE +"H1975","Pearson.est","CHK inhibitor",0.7286,1.85,0.00539,96,0.116,"PF.477736, SB.218078, CHIR.124",2.26841123481326,0.935542010773082,TRUE +"H1975","Pearson.est","cyclooxygenase inhibitor",-0.30811,-0.825,0.643,1343,0.841,"sulfasalazine, metoxibutropate, ketoprofen, tepoxalin",0.191789027075778,0.0752040042020878,FALSE +"H1975","Pearson.est","cytochrome P450 inhibitor",-0.66556,-1.76,0.032,1243,0.136,"cobicistat, itraconazole, eplerenone",1.49485002168009,0.866461091629782,TRUE +"H1975","Pearson.est","DNA alkylating agent",0.43847,1.13,0.321,283,0.77,"dacarbazine, mitomycin.c, melphalan, ifosfamide, estramustine, satraplatin",0.493494967595128,0.113509274827518,FALSE +"H1975","Pearson.est","DNA inhibitor",0.30985,0.801,0.674,293,1,"melphalan, busulfan, metronidazole, primaquine, bendamustine",0.17134010346468,0,FALSE +"H1975","Pearson.est","DNA methyltransferase inhibitor",0.60535,1.51,0.0668,297,0.461,"SGI.1027, fdcyd, azacitidine, disulfiram",1.17522353752445,0.336299074610352,FALSE +"H1975","Pearson.est","DNA polymerase inhibitor",0.23252,0.585,0.916,211,0.989,"trifluridine",0.0381045263321496,0.0048037084028206,FALSE +"H1975","Pearson.est","DNA synthesis inhibitor",0.34019,0.864,0.598,231,0.965,"mitomycin.c, enocitabine, floxuridine",0.223298816011589,0.0154726866562074,FALSE +"H1975","Pearson.est","dopamine receptor antagonist",-0.31192,-0.833,0.654,1273,0.864,"UH.232...., thioproperazine, oxiperomide, nemonapride, raclopride, acetophenazine",0.184422251675733,0.0634862575211067,FALSE +"H1975","Pearson.est","estrogen receptor agonist",-0.37253,-1.01,0.418,989,0.869,"ethinyl.estradiol, estradiol, PPT, estrone",0.378823718224965,0.0609802235513335,FALSE +"H1975","Pearson.est","estrogen receptor antagonist",0.65951,1.71,0.0234,446,0.267,"danazol, toremifene, clomifene, raloxifene, tamoxifen",1.63078414258986,0.573488738635425,FALSE +"H1975","Pearson.est","FGFR inhibitor",0.52125,1.35,0.152,143,0.567,"regorafenib, lenvatinib, lucitanib",0.818156412055227,0.246416941107093,FALSE +"H1975","Pearson.est","FLT3 inhibitor",-0.32192,-0.853,0.626,1376,0.909,"KW.2449, ponatinib, midostaurin",0.20342566678957,0.0414361167780325,FALSE +"H1975","Pearson.est","glucocorticoid receptor agonist",-0.50338,-1.3,0.176,1155,0.433,"prednisolone.hemisuccinate, flumethasone.pivalate, fluocinolone.acetonide, prednisolone, prednisolone.acetate, dexamethasone.acetate, desonide, hydrocortisone, beclomethasone.dipropionate, fluticasone.propionate, piretanide, triamcinolone",0.75448733218585,0.363512103646635,FALSE +"H1975","Pearson.est","glutamate receptor antagonist",0.42402,1.08,0.355,338,0.775,"CGP.37849, MTPG, diazooxonorleucine, IEM1754, CPP, tiletamine, ACDPP",0.449771646944906,0.11069829749369,FALSE +"H1975","Pearson.est","glycogen synthase kinase inhibitor",0.22708,0.571,0.933,43,0.98,"AZD2858",0.0301183562535,0.00877392430750515,FALSE +"H1975","Pearson.est","growth factor receptor inhibitor",0.34018,0.854,0.625,53,0.956,"GW.441756",0.204119982655925,0.0195421077238999,FALSE +"H1975","Pearson.est","HCV inhibitor",0.65648,1.66,0.0309,80,0.262,"PSI.7976, daclatasvir",1.51004152057517,0.581698708680255,FALSE +"H1975","Pearson.est","HDAC inhibitor",-0.22407,-0.592,0.904,1413,0.926,"RG2833, mocetinostat",0.0438315695246367,0.0333890133180656,FALSE +"H1975","Pearson.est","histamine receptor antagonist",0.33009,0.843,0.66,126,0.95,"zolantidine, tecastemizole, cyproheptadine, astemizole",0.180456064458131,0.0222763947111523,FALSE +"H1975","Pearson.est","HMGCR inhibitor",-0.77855,-2.08,0.00212,1211,0.0765,"lovastatin, simvastatin, atorvastatin, fluvastatin, pitavastatin",2.67366413907125,1.11633856484638,TRUE +"H1975","Pearson.est","HSP inhibitor",0.17672,0.463,0.988,331,0.989,"XL888, NMS.E973, SNX.2112",0.00524305541237188,0.0048037084028206,FALSE +"H1975","Pearson.est","JAK inhibitor",0.37282,0.935,0.514,200,0.968,"LY2784544, baricitinib, TG.101348, pacritinib, AZD1480, CEP.33779",0.289036881004724,0.0141246426916063,FALSE +"H1975","Pearson.est","KIT inhibitor",-0.36785,-0.976,0.44,1421,0.835,"midostaurin, dasatinib, KI.8751",0.356547323513813,0.0783135245163979,FALSE +"H1975","Pearson.est","MDM inhibitor",-0.52258,-1.37,0.132,1064,0.498,"CGM097, idasanutlin, serdemetan, AMG.232, RITA",0.87942606879415,0.302770657240282,FALSE +"H1975","Pearson.est","MEK inhibitor",-0.72228,-1.93,0.00883,1190,0.0718,"PD.198306, MEK162, cobimetinib, PD.98059, U.0126, AS.703026, trametinib, Ro.4987655, selumetinib, TAK.733, refametinib, AZD8330, PD.318088, PD.184352",2.05403929642243,1.1438755557577,TRUE +"H1975","Pearson.est","MET inhibitor",-0.25848,-0.676,0.824,1186,0.935,"PF.04217903, LY2801653",0.0840727883028842,0.0291883891274822,FALSE +"H1975","Pearson.est","microtubule inhibitor",0.39257,0.989,0.463,454,0.911,"colchicine, D.64131, podophyllotoxin, triclabendazole, vinflunine",0.334419008982047,0.0404816230270017,FALSE +"H1975","Pearson.est","mTOR inhibitor",-0.51375,-1.36,0.129,1140,0.421,"deforolimus, WYE.354, GDC.0980, OSI.027, PKI.179, MLN0128, everolimus, LY3023414, torin.1, temsirolimus, PF.04691502, NVP.BEZ235, SB.2343",0.889410289700751,0.375717904164332,FALSE +"H1975","Pearson.est","NFkB pathway inhibitor",-0.24944,-0.651,0.874,1167,0.932,"BAY.11.7085, EVP4593, BAY.11.7082",0.058488567365597,0.0305840876460186,FALSE +"H1975","Pearson.est","opioid receptor agonist",0.35097,0.891,0.562,16,0.968,"salvinorin.a",0.250263684430939,0.0141246426916063,FALSE +"H1975","Pearson.est","p38 MAPK inhibitor",0.55923,1.44,0.104,322,0.562,"talmapimod, SB.242235, SB.239063, TAK.715",0.98296666070122,0.250263684430939,FALSE +"H1975","Pearson.est","PARP inhibitor",0.50882,1.3,0.186,21,0.525,"PJ.34",0.730487055782084,0.279840696594043,FALSE +"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.39575,-1.04,0.376,1309,0.862,"linifanib, SU014813, axitinib, ponatinib, dasatinib, KI.8751",0.424812155072339,0.0644927341752872,FALSE +"H1975","Pearson.est","phosphatase inhibitor",0.23457,0.593,0.928,332,1,"AS.1949490, mycophenolic.acid",0.0324520237811379,0,FALSE +"H1975","Pearson.est","phosphodiesterase inhibitor",0.29214,0.737,0.789,334,0.959,"cilostamide, YM.976, enoximone",0.10292299679058,0.0181813928293364,FALSE +"H1975","Pearson.est","PI3K inhibitor",-0.38214,-0.984,0.451,1157,0.868,"GDC.0980, PI3K.IN.2, BGT226, PKI.179, ZSTK.474, LY3023414, buparlisib, GDC.0941, PF.04691502, NVP.BEZ235, SB.2343",0.345823458122039,0.0614802748235081,FALSE +"H1975","Pearson.est","PLK inhibitor",0.67024,1.7,0.0294,311,0.239,"BI.2536, NMS.1286937, GSK461364, GW.843682X, volasertib",1.53165266958784,0.621602099051862,TRUE +"H1975","Pearson.est","potassium channel blocker",0.42929,1.08,0.368,305,0.775,"dofetilide, oleoylethanolamide, ML133",0.434152181326482,0.11069829749369,FALSE +"H1975","Pearson.est","PPAR receptor agonist",-0.34142,-0.878,0.584,1065,0.903,"clofibrate, pterostilbene, fenofibrate",0.233587152887601,0.0443122496864942,FALSE +"H1975","Pearson.est","progesterone receptor agonist",-0.48485,-1.31,0.18,1194,0.454,"norgestrel, norethindrone, tanaproget",0.744727494896694,0.342944147142896,FALSE +"H1975","Pearson.est","proteasome inhibitor",0.54073,1.41,0.109,567,0.574,"MG.132, ixazomib, delanzomib, carfilzomib, bortezomib",0.962573502059376,0.241088107602027,FALSE +"H1975","Pearson.est","protein synthesis inhibitor",0.45514,1.16,0.277,426,0.74,"bruceantin, homoharringtonine, harringtonine, puromycin, chloramphenicol.palmitate, clofoctol, thiostrepton, anguidine, emetine, tedizolid.phosphate",0.557520230935551,0.130768280269024,FALSE +"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.34072,0.877,0.614,290,0.967,"tyrphostin.A9, CP.724714, AV.412, BMS.599626",0.211831628858832,0.0145735259169983,FALSE +"H1975","Pearson.est","RAF inhibitor",0.53115,1.35,0.147,557,0.567,"regorafenib, SB.590885, AZ.628, CEP.32496, GDC.0879, vemurafenib, LGX818, dabrafenib, RAF265, sorafenib",0.832682665251824,0.246416941107093,FALSE +"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.36759,0.921,0.51,236,0.935,"regorafenib, apatinib",0.292429823902064,0.0291883891274822,FALSE +"H1975","Pearson.est","retinoid receptor agonist",0.60436,1.53,0.0828,198,0.476,"adarotene, AM.580, tamibarotene, CD.437",1.08196966321512,0.322393047279507,FALSE +"H1975","Pearson.est","ribonucleotide reductase inhibitor",0.19065,0.485,0.991,473,1,"fludarabine.phosphate, gemcitabine, fludarabine",0.00392634551472468,0,FALSE +"H1975","Pearson.est","serotonin receptor agonist",-0.52503,-1.38,0.147,1447,0.541,"aripiprazole",0.832682665251824,0.266802734893431,FALSE +"H1975","Pearson.est","serotonin receptor antagonist",-0.28748,-0.762,0.727,1447,0.878,"aripiprazole",0.138465589140962,0.0565054840938974,FALSE +"H1975","Pearson.est","sodium channel blocker",-0.30052,-0.796,0.66,1038,0.855,"A.803467, oxcarbazepine, benzocaine, mexiletine, benzethonium, mepivacaine",0.180456064458131,0.0680338852718274,FALSE +"H1975","Pearson.est","src inhibitor",0.28521,0.728,0.772,298,0.929,"KX2.391, TG.100572, saracatinib",0.112382699664264,0.0319842860063582,FALSE +"H1975","Pearson.est","sterol demethylase inhibitor",0.31027,0.793,0.714,403,0.961,"ketoconazole, lanoconazole, posaconazole",0.146301788223826,0.0172766123314547,FALSE +"H1975","Pearson.est","TGF beta receptor inhibitor",0.74997,1.92,0.0053,307,0.246,"LY2109761, SB.525334, repsox, D.4476",2.27572413039921,0.609064892896621,TRUE +"H1975","Pearson.est","thymidylate synthase inhibitor",0.73976,1.91,0.00735,292,0.134,"ftorafur, doxifluridine, raltitrexed, trifluridine, carmofur",2.13371266091581,0.872895201635192,TRUE +"H1975","Pearson.est","topoisomerase inhibitor",0.27317,0.695,0.823,249,0.954,"dexrazoxane, SN.38, exatecan.mesylate, genz.644282, camptothecin, topotecan",0.0846001647877302,0.0204516252959049,FALSE +"H1975","Pearson.est","tubulin polymerization inhibitor",0.50617,1.3,0.192,397,0.525,"vinorelbine, vincristine, KX2.391, CYT.997, combretastatin.A.4, taltobulin, oxibendazole, podophyllotoxin, plinabulin, dolastatin.10, albendazole, indibulin",0.71669877129645,0.279840696594043,FALSE +"H1975","Pearson.est","tyrosine kinase inhibitor",-0.35049,-0.948,0.491,1322,0.805,"mubritinib, cabozantinib, aminopurvalanol.a, UNC2250, dasatinib, NVP.TAE226",0.308918507877032,0.0942041196321315,FALSE +"H1975","Pearson.est","VEGFR inhibitor",-0.26555,-0.72,0.782,1309,0.909,"linifanib, semaxanib, SAR131675, SU014813, cabozantinib, axitinib, KI.8751",0.106793246940152,0.0414361167780325,FALSE +"H1975","Pearson.est","vitamin D receptor agonist",0.50276,1.31,0.182,34,0.571,"maxacalcitol",0.739928612014925,0.243363891754152,FALSE +"H2009","Pearson.est","EGFR inhibitor",-0.29935,-0.734,0.82,1028,0.896,"rociletinib, osimertinib, OSI.420, tyrphostin.AG.494, pelitinib, canertinib, WZ8040, gefitinib, PD.153035, afatinib, erlotinib, TAK.285, icotinib, BIBX.1382, tyrphostin.AG.1478, BIBU.1361",0.0861861476162833,0.0476919903378748,FALSE +"H2009","Pearson.est","Abl kinase inhibitor",-0.23614,-0.59,0.932,1275,0.961,"bafetinib, bosutinib",0.0305840876460186,0.0172766123314547,FALSE +"H2009","Pearson.est","acetylcholine receptor agonist",0.28183,0.785,0.702,35,0.905,"xanomeline",0.153662887870195,0.0433514207947967,FALSE +"H2009","Pearson.est","acetylcholine receptor antagonist",-0.49055,-1.2,0.247,1281,0.891,"dicycloverine, diphemanil",0.607303046740334,0.0501222959631252,FALSE +"H2009","Pearson.est","adenosine receptor antagonist",-0.47233,-1.19,0.267,1080,0.872,"SCH.58261, CGS.15943, sulmazole",0.573488738635425,0.0594835150674328,FALSE +"H2009","Pearson.est","adrenergic receptor agonist",-0.28913,-0.716,0.809,755,0.901,"norepinephrine, xylazine, terbutaline, oxymetazoline, A61603, metaraminol, isoxsuprine, clenbuterol, buphenine, epinephrine",0.0920514783877277,0.045275209020937,FALSE +"H2009","Pearson.est","adrenergic receptor antagonist",-0.36146,-0.895,0.594,1256,0.911,"carvedilol, pindolol, levobunolol, propranolol, vincamine",0.226213555018806,0.0404816230270017,FALSE +"H2009","Pearson.est","AKT inhibitor",-0.42941,-1.07,0.365,951,0.849,"AZD5363, GDC.0068, ONC201, CCT128930, uprosertib, triciribine, palomid.529",0.437707135543525,0.0710923097560473,FALSE +"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.4148,-1.03,0.414,844,0.855,"lorlatinib, crizotinib, NVP.TAE684, DMH1, AZD3463, GW.788388",0.382999658879101,0.0680338852718274,FALSE +"H2009","Pearson.est","androgen receptor antagonist",-0.38341,-0.948,0.535,883,0.876,"cyproterone.acetate, flutamide, nilutamide, bicalutamide",0.271646217978772,0.0574958938319193,FALSE +"H2009","Pearson.est","antioxidant",0.37078,1.05,0.385,20,0.941,"trolox",0.414539270491499,0.0264103765727431,FALSE +"H2009","Pearson.est","AP inhibitor",-0.27927,-0.683,0.851,830,0.909,"birinapant, embelin, GDC.0152, tanshinone.i, LCL.161",0.0700704399154121,0.0414361167780325,FALSE +"H2009","Pearson.est","ATPase inhibitor",0.71635,2.03,0.00746,245,0.211,"k.strophanthidin, oligomycin.a, omeprazole, NMS.873, digoxin, evodiamine, blebbistatin....",2.12726117252733,0.675717544702307,TRUE +"H2009","Pearson.est","Aurora kinase inhibitor",-0.2121,-0.526,0.963,754,0.966,"AMG900, CCT137690, alisertib, tozasertib, GSK1070916, MK.8745, KW.2449, ZM.447439, hesperadin, MK.5108, PF.03814735, MLN.8054",0.0163737128754655,0.0150228735845067,FALSE +"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.37131,-0.895,0.584,868,0.911,"dirithromycin, tedizolid, azalomycin.b, azithromycin",0.233587152887601,0.0404816230270017,FALSE +"H2009","Pearson.est","bacterial DNA gyrase inhibitor",-0.40766,-1.01,0.446,856,0.845,"lomefloxacin, sarafloxacin, finafloxacin, novobiocin, trovafloxacin",0.350665141287858,0.0731432910503077,FALSE +"H2009","Pearson.est","BCL inhibitor",0.38793,1.11,0.322,363,0.892,"ABT.737, gossypol, TW.37, venetoclax, navitoclax, obatoclax",0.492144128304169,0.0496351456238769,FALSE +"H2009","Pearson.est","Bcr.Abl kinase inhibitor",-0.31054,-0.769,0.764,1275,0.899,"bafetinib, bosutinib",0.11690664142431,0.0462403082667712,FALSE +"H2009","Pearson.est","benzodiazepine receptor agonist",-0.34366,-0.844,0.662,788,0.896,"gamma.aminobutyric.acid, ivermectin, piperazine, indiplon, CGS.20625, ZK.93423, zaleplon",0.1791420105603,0.0476919903378748,FALSE +"H2009","Pearson.est","bromodomain inhibitor",-0.36322,-0.891,0.609,738,0.875,"I.BET151, I.BET.762, bromosporine, JQ1....",0.215382707367125,0.0579919469776868,FALSE +"H2009","Pearson.est","calcium channel blocker",0.31958,0.913,0.556,83,0.87,"efonidipine.monoethanolate, carboxyamidotriazole",0.254925208417942,0.0604807473813815,FALSE +"H2009","Pearson.est","CC chemokine receptor antagonist",-0.46745,-1.16,0.288,1201,0.828,"MK.0812, PF.04136309, navarixin",0.540607512240769,0.0819696632151199,FALSE +"H2009","Pearson.est","CDK inhibitor",-0.4684,-1.15,0.308,1312,0.817,"arcyriaflavin.a, BMS.387032, kenpaullone, PHA.793887, AZD5438, alvocidib",0.511449283499556,0.0877779434675845,FALSE +"H2009","Pearson.est","CHK inhibitor",-0.46918,-1.17,0.276,807,0.841,"CHIR.124, SCH.900776, SB.218078, LY2603618, LY2606368",0.559090917934782,0.0752040042020878,FALSE +"H2009","Pearson.est","cyclooxygenase inhibitor",-0.51028,-1.26,0.202,1207,0.863,"FR.122047, meloxicam, indoprofen, amfenac, curcumin, ramifenazone, aspirin, FK.3311",0.694648630553376,0.0639892042847904,FALSE +"H2009","Pearson.est","cytochrome P450 inhibitor",-0.35944,-0.891,0.595,981,0.875,"cobicistat, clotrimazole, PF.4981517",0.22548303427145,0.0579919469776868,FALSE +"H2009","Pearson.est","DNA alkylating agent",-0.53922,-1.35,0.136,923,0.826,"ifosfamide, satraplatin, dianhydrogalactitol, TH.302, cyclophosphamide, mitomycin.c, carboplatin, streptozotocin, melphalan, dacarbazine",0.866461091629782,0.0830199526796178,FALSE +"H2009","Pearson.est","DNA inhibitor",-0.42381,-1.05,0.402,984,0.866,"primaquine, valrubicin, nimorazole, tirapazamine, carboplatin, sangivamycin, bendamustine, busulfan, melphalan, nithiamide",0.39577394691553,0.0624821079826534,FALSE +"H2009","Pearson.est","DNA methyltransferase inhibitor",-0.63065,-1.54,0.0433,1093,0.445,"fdcyd, SGI.1027, decitabine, azacitidine",1.36351210364663,0.351639989019068,FALSE +"H2009","Pearson.est","DNA polymerase inhibitor",0.31384,0.872,0.58,201,0.9,"menadione, adefovir.dipivoxil, cidofovir",0.236572006437063,0.0457574905606751,FALSE +"H2009","Pearson.est","DNA synthesis inhibitor",-0.54155,-1.36,0.144,1076,0.876,"mitomycin.c, estramustine.phosphate, cyclocytidine, anisomycin, CB.10.277, floxuridine, altretamine",0.84163750790475,0.0574958938319193,FALSE +"H2009","Pearson.est","dopamine receptor antagonist",-0.32924,-0.813,0.69,933,0.87,"oxiperomide, acetophenazine, sertindole, ziprasidone, amisulpride, piperacetazine, isofloxythepin",0.161150909262745,0.0604807473813815,FALSE +"H2009","Pearson.est","estrogen receptor agonist",-0.35421,-0.883,0.603,1139,0.849,"estradiol.cypionate, PPT, ethinyl.estradiol",0.219682687859849,0.0710923097560473,FALSE +"H2009","Pearson.est","estrogen receptor antagonist",-0.37333,-0.912,0.573,804,0.926,"danazol, fulvestrant, clomifene, raloxifene, toremifene",0.24184537803261,0.0333890133180656,FALSE +"H2009","Pearson.est","FGFR inhibitor",0.48853,1.4,0.103,127,0.578,"erdafitinib, lenvatinib, dovitinib",0.987162775294828,0.238072161579471,FALSE +"H2009","Pearson.est","FLT3 inhibitor",0.35304,0.968,0.471,191,0.961,"ponatinib, TG.101348, sorafenib, dovitinib, GTP.14564, ENMD.2076",0.326979092871104,0.0172766123314547,FALSE +"H2009","Pearson.est","glucocorticoid receptor agonist",0.59023,1.66,0.0497,290,0.384,"dexamethasone.acetate, triamcinolone.acetonide, hydrocortisone, halcinonide, beclomethasone.dipropionate, triamcinolone, desonide, flumethasone.pivalate, deflazacort, fluticasone.propionate, piretanide, betamethasone, rimexolone, fluocinolone.acetonide, prednisolone.hemisuccinate, ciclesonide",1.30364361126667,0.415668775632469,FALSE +"H2009","Pearson.est","glutamate receptor antagonist",-0.40306,-1.01,0.45,869,0.845,"JNJ.16259685, MTPG, SIB.1757, tiletamine, ACDPP, latrepirdine, diazooxonorleucine",0.346787486224656,0.0731432910503077,FALSE +"H2009","Pearson.est","glycogen synthase kinase inhibitor",-0.49142,-1.22,0.239,847,0.94,"CHIR.99021, tideglusib, LY2090314, GSK.3.inhibitor.IX, kenpaullone, AZD2858",0.621602099051862,0.0268721464003014,FALSE +"H2009","Pearson.est","growth factor receptor inhibitor",-0.2862,-0.704,0.845,962,0.9,"GSK1838705A, AZD3463, GW.441756",0.0731432910503077,0.0457574905606751,FALSE +"H2009","Pearson.est","HCV inhibitor",-0.6967,-1.72,0.0195,1354,0.474,"narlaprevir, PSI.7976, daclatasvir",1.70996538863748,0.324221658325915,FALSE +"H2009","Pearson.est","HDAC inhibitor",-0.46157,-1.14,0.307,902,0.807,"pyroxamide, dacinostat, nexturastat.a, givinostat, chidamide, entinostat, M.344, AR.42, tacedinaline, romidepsin, PCI.24781, R306465, vorinostat, panobinostat, JNJ.26481585, SB.939",0.512861624522813,0.0931264652779296,FALSE +"H2009","Pearson.est","histamine receptor antagonist",-0.53774,-1.32,0.168,886,0.727,"ranitidine, astemizole, tiotidine, cyproheptadine, levocetirizine, cimetidine, ICI.162846, nizatidine, famotidine, lafutidine, pheniramine, tecastemizole, terfenadine, chloropyramine, zolantidine",0.774690718274137,0.138465589140962,FALSE +"H2009","Pearson.est","HMGCR inhibitor",-0.31223,-0.771,0.736,1018,0.914,"simvastatin, mevastatin",0.133122185662501,0.0390538042661686,FALSE +"H2009","Pearson.est","HSP inhibitor",-0.55629,-1.37,0.124,1110,0.942,"VER.49009, SNX.2112, BIIB021, PU.H71, NVP.AUY922, tanespimycin, XL888, SNX.5422",0.906578314837765,0.0259490972071227,FALSE +"H2009","Pearson.est","JAK inhibitor",-0.33464,-0.837,0.656,1204,0.889,"pacritinib, atiprimod, CEP.33779, WHI.P154, LY2784544",0.18309616062434,0.0510982390297863,FALSE +"H2009","Pearson.est","KIT inhibitor",0.26596,0.762,0.716,340,0.896,"lenvatinib, sorafenib, pazopanib, dasatinib, motesanib, cediranib, midostaurin",0.145086977692144,0.0476919903378748,FALSE +"H2009","Pearson.est","MDM inhibitor",-0.40087,-0.979,0.495,853,0.862,"RITA, nutlin.3, serdemetan",0.305394801066431,0.0644927341752872,FALSE +"H2009","Pearson.est","MEK inhibitor",-0.30345,-0.748,0.76,742,0.894,"cobimetinib, PD.184352, PD.98059, AS.703026, arctigenin, PD.0325901, trametinib, TAK.733, Ro.4987655, PD.198306, BIX.02188, nobiletin",0.119186407719209,0.0486624812040823,FALSE +"H2009","Pearson.est","MET inhibitor",-0.67304,-1.64,0.028,1070,0.331,"LY2801653, AMG458, PF.04217903, NVP.BVU972, INC.280",1.55284196865778,0.480172006224281,FALSE +"H2009","Pearson.est","microtubule inhibitor",-0.45286,-1.1,0.379,1119,0.808,"estramustine.phosphate, cabazitaxel, D.64131, podophyllotoxin",0.421360790031928,0.0925886392254138,FALSE +"H2009","Pearson.est","mTOR inhibitor",0.31171,0.861,0.569,212,0.814,"OSI.027, torin.1, WYE.354, PF.04691502, voxtalisib, XL388, SB.2343, AZD2014, everolimus, WYE.125132",0.244887733604929,0.0893755951107988,FALSE +"H2009","Pearson.est","NFkB pathway inhibitor",0.34127,0.935,0.495,25,0.888,"EVP4593, tyloxapol",0.305394801066431,0.051587034221399,FALSE +"H2009","Pearson.est","opioid receptor agonist",-0.44161,-1.1,0.353,1436,0.808,"salvinorin.a",0.452225294612177,0.0925886392254138,FALSE +"H2009","Pearson.est","p38 MAPK inhibitor",-0.66877,-1.66,0.0233,1356,0.49,"VX.702, TAK.715, CMPD.1",1.63264407897398,0.309803919971486,FALSE +"H2009","Pearson.est","PARP inhibitor",-0.52849,-1.32,0.151,1043,0.727,"talazoparib, niraparib, olaparib, PJ.34",0.821023052706831,0.138465589140962,FALSE +"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.39997,1.14,0.285,276,0.932,"axitinib, ponatinib, lenvatinib, linifanib, sorafenib, dovitinib, SU014813, pazopanib, dasatinib, nintedanib, motesanib",0.54515513999149,0.0305840876460186,FALSE +"H2009","Pearson.est","phosphatase inhibitor",0.34829,0.997,0.443,178,0.98,"GSK2830371, CID.5458317, menadione",0.35359627377693,0.00877392430750515,FALSE +"H2009","Pearson.est","phosphodiesterase inhibitor",-0.44568,-1.12,0.334,1213,0.822,"cilostamide, zardaverine, YM.976, EMD.53998",0.476253533188435,0.0851281824599496,FALSE +"H2009","Pearson.est","PI3K inhibitor",0.23092,0.672,0.851,329,0.98,"ZSTK.474, GDC.0941, PF.04691502, PI3K.IN.2, voxtalisib, SB.2343, buparlisib, LY3023414, PI.828, TG100.115, idelalisib",0.0700704399154121,0.00877392430750515,FALSE +"H2009","Pearson.est","PLK inhibitor",-0.47468,-1.17,0.251,888,0.841,"GW.843682X, GSK461364, HMN.214, BI.2536",0.600326278518962,0.0752040042020878,FALSE +"H2009","Pearson.est","potassium channel blocker",-0.53939,-1.34,0.123,1248,0.785,"oleoylethanolamide, meglitinide",0.910094888560602,0.105130343254747,FALSE +"H2009","Pearson.est","PPAR receptor agonist",0.22181,0.618,0.888,173,0.95,"fenofibrate, clofibrate",0.051587034221399,0.0222763947111523,FALSE +"H2009","Pearson.est","progesterone receptor agonist",0.54162,1.54,0.0641,171,0.441,"norethindrone, tanaproget, levonorgestrel",1.19314197048118,0.355561410532161,FALSE +"H2009","Pearson.est","proteasome inhibitor",-0.68297,-1.65,0.0192,997,0.389,"carfilzomib, MG.132, ONX.0914, bortezomib, delanzomib, ixazomib.citrate, ixazomib",1.71669877129645,0.410050398674292,FALSE +"H2009","Pearson.est","protein synthesis inhibitor",-0.23175,-0.57,0.94,943,0.958,"mercaptopurine, brefeldin.a, azomycin..2.nitroimidazole., thiostrepton, puromycin, homoharringtonine, emetine",0.0268721464003014,0.0186344909214556,FALSE +"H2009","Pearson.est","protein tyrosine kinase inhibitor",0.48737,1.35,0.172,42,0.572,"mubritinib, PP.121",0.764471553092451,0.242603971206976,FALSE +"H2009","Pearson.est","RAF inhibitor",-0.41604,-1.04,0.399,1208,0.861,"vemurafenib, GDC.0879, dabrafenib, CEP.32496, LGX818",0.399027104313252,0.0649968485463452,FALSE +"H2009","Pearson.est","RET tyrosine kinase inhibitor",-0.27293,-0.68,0.852,774,0.896,"regorafenib, cabozantinib, vandetanib, apatinib",0.0695604052332999,0.0476919903378748,FALSE +"H2009","Pearson.est","retinoid receptor agonist",-0.39098,-0.981,0.489,1181,0.884,"tamibarotene, AM.580, CD.437",0.31069114087638,0.0535477349869269,FALSE +"H2009","Pearson.est","ribonucleotide reductase inhibitor",-0.32887,-0.822,0.687,1225,0.875,"clofarabine, fludarabine.phosphate, fludarabine",0.16304326294045,0.0579919469776868,FALSE +"H2009","Pearson.est","serotonin receptor agonist",0.66134,1.82,0.0179,103,0.291,"aripiprazole, zolmitriptan",1.74714696902011,0.536107011014093,FALSE +"H2009","Pearson.est","serotonin receptor antagonist",0.2989,0.863,0.601,2,0.861,"aripiprazole",0.22112552799726,0.0649968485463452,FALSE +"H2009","Pearson.est","sodium channel blocker",0.19438,0.552,0.976,120,0.959,"cibenzoline, benzethonium",0.0105501823333082,0.0181813928293364,FALSE +"H2009","Pearson.est","src inhibitor",-0.38418,-0.949,0.528,1029,0.899,"PP.2, saracatinib, KX2.391, bosutinib",0.277366077466188,0.0462403082667712,FALSE +"H2009","Pearson.est","sterol demethylase inhibitor",-0.35868,-0.89,0.589,1237,0.857,"ketoconazole, lanoconazole",0.229884705212898,0.0670191780768018,FALSE +"H2009","Pearson.est","TGF beta receptor inhibitor",-0.66209,-1.63,0.0352,1369,0.298,"D.4476, LY2109761",1.45345733652187,0.525783735923745,FALSE +"H2009","Pearson.est","thymidylate synthase inhibitor",-0.77207,-1.92,0.00424,1259,0.14,"raltitrexed, carmofur, doxifluridine",2.37263414340727,0.853871964321762,TRUE +"H2009","Pearson.est","topoisomerase inhibitor",-0.4855,-1.2,0.229,944,0.891,"TAS.103, teniposide, valrubicin, etoposide, amsacrine, topotecan, amonafide, irinotecan, nemorubicin, rubitecan, licochalcone.a, SN.38, camptothecin, genz.644282, exatecan.mesylate",0.640164517660112,0.0501222959631252,FALSE +"H2009","Pearson.est","tubulin polymerization inhibitor",-0.33092,-0.822,0.682,1086,0.875,"mebendazole, epothilone.b, epothilone.d, fosbretabulin, podophyllotoxin, KX2.391, taltobulin, combretastatin.A.4",0.166215625343521,0.0579919469776868,FALSE +"H2009","Pearson.est","tyrosine kinase inhibitor",0.2291,0.67,0.896,213,0.936,"mubritinib, PP.121, sorafenib, GTP.14564, dasatinib, UNC2250",0.0476919903378748,0.0287241512618947,FALSE +"H2009","Pearson.est","VEGFR inhibitor",0.33574,0.957,0.431,191,0.908,"axitinib, lenvatinib, linifanib, sorafenib, dovitinib, semaxanib, SU014813, ZM.306416, pazopanib, ENMD.2076",0.365522729839268,0.0419141514789149,FALSE +"H2009","Pearson.est","vitamin D receptor agonist",-0.30587,-0.753,0.782,1422,0.904,"ercalcitriol",0.106793246940152,0.0438315695246367,FALSE +"H2126","Pearson.est","EGFR inhibitor",-0.46085,-1.16,0.291,1176,0.629,"rociletinib, poziotinib, tucatinib, CNX.2006, BIBX.1382, GW.583340, BMS.599626, vandetanib, CGP.52411, dacomitinib, BIBU.1361, pelitinib, PD.168393, PD.153035, OSI.420, AST.1306, CP.724714, WZ8040",0.536107011014093,0.201349354554731,FALSE +"H2126","Pearson.est","Abl kinase inhibitor",0.32019,0.832,0.624,351,0.836,"GZD824, bafetinib, ponatinib, nilotinib, KW.2449, dasatinib",0.204815410317576,0.0777937225609836,FALSE +"H2126","Pearson.est","acetylcholine receptor agonist",-0.30475,-0.779,0.73,1400,0.852,"oxiracetam",0.136677139879544,0.0695604052332999,FALSE +"H2126","Pearson.est","acetylcholine receptor antagonist",-0.53802,-1.38,0.149,959,0.609,"methscopolamine, darifenacin, diphemanil, dicycloverine",0.826813731587726,0.215382707367125,FALSE +"H2126","Pearson.est","adenosine receptor antagonist",-0.63133,-1.6,0.0505,1320,0.575,"MRS.1220, CGS.15943, istradefylline",1.29670862188134,0.24033215531037,FALSE +"H2126","Pearson.est","adrenergic receptor agonist",0.37514,0.994,0.427,277,0.745,"epinephrine, norepinephrine, terbutaline, buphenine, clenbuterol, ritodrine",0.369572124974976,0.127843727251707,FALSE +"H2126","Pearson.est","adrenergic receptor antagonist",-0.30502,-0.79,0.696,1091,0.882,"RS.17053, prazosin, atenolol...., pindolol, imiloxan, dronedarone",0.157390760389438,0.0545314148681803,FALSE +"H2126","Pearson.est","AKT inhibitor",-0.40204,-1.03,0.42,1293,0.722,"CCT128930, A.674563, AT7867",0.3767507096021,0.141462802430361,FALSE +"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.53668,1.43,0.107,367,0.508,"brigatinib, alectinib, DMH1, CEP.37440, crizotinib, lorlatinib, SB.505124",0.97061622231479,0.294136287716081,FALSE +"H2126","Pearson.est","androgen receptor antagonist",-0.59537,-1.51,0.0893,914,0.595,"nilutamide, flutamide, cyproterone.acetate, enzalutamide, RU.58841",1.04914854111145,0.22548303427145,FALSE +"H2126","Pearson.est","antioxidant",-0.52701,-1.33,0.175,1017,0.606,"taurine, trolox, benfotiamine",0.756961951313706,0.217527375833714,FALSE +"H2126","Pearson.est","AP inhibitor",-0.5653,-1.46,0.0958,1308,0.552,"embelin, tanshinone.i",1.01863449092146,0.258060922270801,FALSE +"H2126","Pearson.est","ATPase inhibitor",0.44028,1.16,0.289,313,0.719,"digitoxigenin, digitoxin, oligomycin.a, rabeprazole, NMS.873, ouabain",0.539102157243452,0.143271109617117,FALSE +"H2126","Pearson.est","Aurora kinase inhibitor",0.37737,1.01,0.441,431,0.745,"CCT137690, AMG900, MK.8745, barasertib, KW.2449, PF.03814735, danusertib, GSK1070916, MK.5108, ENMD.2076, barasertib.HQPA",0.355561410532161,0.127843727251707,FALSE +"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34088,-0.855,0.599,1288,0.878,"valnemulin, tilmicosin",0.222573177610689,0.0565054840938974,FALSE +"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.33241,0.89,0.572,263,0.819,"sparfloxacin, finafloxacin, lomefloxacin",0.242603971206976,0.0867160982395816,FALSE +"H2126","Pearson.est","BCL inhibitor",-0.24512,-0.62,0.915,1380,0.901,"obatoclax",0.0385789059335517,0.045275209020937,FALSE +"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.41554,1.09,0.351,222,0.733,"GZD824, bafetinib, ponatinib, nilotinib",0.454692883534176,0.134896025358872,FALSE +"H2126","Pearson.est","benzodiazepine receptor agonist",0.34471,0.894,0.563,147,0.843,"bentazepam, piperazine, ZK.93423",0.249491605148654,0.0741724253752577,FALSE +"H2126","Pearson.est","bromodomain inhibitor",-0.50317,-1.29,0.209,936,0.644,"I.BET151, I.BET.762, bromosporine",0.679853713888946,0.191114132640188,FALSE +"H2126","Pearson.est","calcium channel blocker",-0.45827,-1.18,0.292,1143,0.625,"SKF.96365, tetrandrine, SR.33805, cinnarazine, mibefradil",0.534617148551582,0.204119982655925,FALSE +"H2126","Pearson.est","CC chemokine receptor antagonist",0.73018,1.88,0.0155,37,0.239,"UNBS.5162, ZK811752",1.80966830182971,0.621602099051862,TRUE +"H2126","Pearson.est","CDK inhibitor",-0.44611,-1.11,0.34,1191,0.633,"kenpaullone, dinaciclib, arcyriaflavin.a, ribociclib, AT.7519, CR8..R., TG.02, indirubin",0.468521082957745,0.198596289982645,FALSE +"H2126","Pearson.est","CHK inhibitor",-0.42298,-1.08,0.367,1216,0.658,"AZD7762, CHIR.124",0.435333935747911,0.181774106386044,FALSE +"H2126","Pearson.est","cyclooxygenase inhibitor",-0.32954,-0.841,0.643,1314,0.849,"FR.122047, phenylbutazone, naproxen, tryptanthrin",0.191789027075778,0.0710923097560473,FALSE +"H2126","Pearson.est","cytochrome P450 inhibitor",-0.37239,-0.958,0.478,1435,0.799,"itraconazole",0.320572103387881,0.0974532206860086,FALSE +"H2126","Pearson.est","DNA alkylating agent",0.28984,0.767,0.742,476,0.917,"dianhydrogalactitol, carboplatin, carmustine, melphalan, mitomycin.c, cyclophosphamide, estramustine",0.129596094720973,0.0376306643299789,FALSE +"H2126","Pearson.est","DNA inhibitor",0.3933,1.04,0.397,287,0.721,"teroxirone, chlorambucil, carboplatin, mechlorethamine, carmustine, melphalan, tirapazamine",0.401209493236885,0.142064735280571,FALSE +"H2126","Pearson.est","DNA methyltransferase inhibitor",0.40835,1.05,0.362,226,0.736,"SGI.1027, decitabine",0.441291429466834,0.133122185662501,FALSE +"H2126","Pearson.est","DNA polymerase inhibitor",-0.32802,-0.845,0.626,1271,0.867,"adefovir.dipivoxil, cidofovir",0.20342566678957,0.0619809025237897,FALSE +"H2126","Pearson.est","DNA synthesis inhibitor",-0.28007,-0.704,0.8,1145,0.87,"estramustine.phosphate, cisplatin, anisomycin, altretamine",0.0969100130080564,0.0604807473813815,FALSE +"H2126","Pearson.est","dopamine receptor antagonist",-0.44618,-1.18,0.272,1175,0.625,"clebopride, oxiperomide, acetophenazine, piperacetazine, nemonapride, remoxipride",0.565431095965801,0.204119982655925,FALSE +"H2126","Pearson.est","estrogen receptor agonist",-0.25919,-0.675,0.845,1173,0.864,"equol, PPT",0.0731432910503077,0.0634862575211067,FALSE +"H2126","Pearson.est","estrogen receptor antagonist",-0.33359,-0.879,0.573,1383,0.892,"tamoxifen",0.24184537803261,0.0496351456238769,FALSE +"H2126","Pearson.est","FGFR inhibitor",0.44361,1.2,0.217,82,0.802,"erdafitinib, dovitinib, regorafenib",0.66354026615147,0.0958256317158365,FALSE +"H2126","Pearson.est","FLT3 inhibitor",0.28893,0.754,0.745,316,0.909,"dovitinib, tyrphostin.AG.1296, ponatinib, sorafenib, tandutinib, KW.2449, gilteritinib",0.127843727251707,0.0414361167780325,FALSE +"H2126","Pearson.est","glucocorticoid receptor agonist",0.32333,0.865,0.578,497,0.835,"fluticasone.propionate, ciclesonide, prednisolone, flumethasone.pivalate, prednisolone.hemisuccinate, fluocinolone.acetonide, triamcinolone, halobetasol.propionate, betamethasone, desonide, triamcinolone.acetonide, clobetasol.propionate, prednisolone.acetate, fludroxycortide, beclomethasone.dipropionate, halcinonide",0.238072161579471,0.0783135245163979,FALSE +"H2126","Pearson.est","glutamate receptor antagonist",-0.30456,-0.77,0.72,1353,0.843,"latrepirdine, CPP",0.142667503568732,0.0741724253752577,FALSE +"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.5508,-1.43,0.111,1029,0.557,"CHIR.98014, AZD2858, kenpaullone, LY2090314, GSK.3.inhibitor.IX, indirubin",0.954677021213343,0.254144804826271,FALSE +"H2126","Pearson.est","growth factor receptor inhibitor",0.56368,1.48,0.0899,76,0.545,"PHA.848125, GSK1838705A",1.04624030826677,0.263603497723358,FALSE +"H2126","Pearson.est","HCV inhibitor",0.37343,0.988,0.453,244,0.726,"narlaprevir, daclatasvir, mericitabine",0.343901797987168,0.139063379299906,FALSE +"H2126","Pearson.est","HDAC inhibitor",-0.62682,-1.59,0.0478,1024,0.482,"givinostat, AR.42, dacinostat, RGFP966, resminostat, ACY.1215, vorinostat, tacedinaline, panobinostat, PCI.24781, R306465, M.344, RG2833, entinostat, mocetinostat, SB.939, scriptaid, romidepsin, JNJ.26481585",1.32057210338788,0.31695296176115,FALSE +"H2126","Pearson.est","histamine receptor antagonist",-0.44722,-1.15,0.298,1092,0.616,"astemizole, tiotidine, levocetirizine, ranitidine, epinastine, famotidine, BF2.649, tecastemizole, chloropyramine",0.525783735923745,0.210419287835575,FALSE +"H2126","Pearson.est","HMGCR inhibitor",-0.32004,-0.798,0.693,901,0.895,"lovastatin, simvastatin, mevastatin",0.159266765388193,0.048176964684088,FALSE +"H2126","Pearson.est","HSP inhibitor",-0.35052,-0.885,0.558,1165,0.912,"alvespimycin, XL888, tanespimycin, KW.2478, VER.49009",0.253365801062421,0.0400051616715838,FALSE +"H2126","Pearson.est","JAK inhibitor",-0.3005,-0.763,0.738,1404,0.831,"TG.02, pacritinib",0.131943638176958,0.080398976215889,FALSE +"H2126","Pearson.est","KIT inhibitor",0.2613,0.683,0.829,252,0.905,"regorafenib, OSI.930, masitinib, sorafenib, tandutinib",0.0814454694497265,0.0433514207947967,FALSE +"H2126","Pearson.est","MDM inhibitor",-0.50166,-1.28,0.202,1025,0.62,"nutlin.3, idasanutlin, AMG.232, CGM097, RITA",0.694648630553376,0.207608310501746,FALSE +"H2126","Pearson.est","MEK inhibitor",-0.3391,-0.869,0.584,1254,0.88,"TAK.733, selumetinib, BIX.02188, nobiletin",0.233587152887601,0.0555173278498314,FALSE +"H2126","Pearson.est","MET inhibitor",0.4158,1.08,0.337,89,0.713,"LY2801653",0.472370099128661,0.146910470148134,FALSE +"H2126","Pearson.est","microtubule inhibitor",-0.2834,-0.735,0.771,1145,0.85,"estramustine.phosphate, triclabendazole, colchicine, cytochalasin.b",0.112945621949043,0.0705810742857073,FALSE +"H2126","Pearson.est","mTOR inhibitor",0.40679,1.1,0.339,266,0.754,"ku.0063794, PP242, AZD2014, PI.103, SB.2343, MLN0128, WYE.125132, OSI.027",0.469800301796918,0.122628654130226,FALSE +"H2126","Pearson.est","NFkB pathway inhibitor",-0.46538,-1.21,0.251,1051,0.683,"betulinic.acid, bortezomib, BAY.11.7085, IKK.2.inhibitor.V, tyloxapol, Ro.106.9920, parthenolide",0.600326278518962,0.165579296318467,FALSE +"H2126","Pearson.est","opioid receptor agonist",-0.37593,-0.96,0.482,1179,0.826,"salvinorin.a, cebranopadol, ADL5859",0.31695296176115,0.0830199526796178,FALSE +"H2126","Pearson.est","p38 MAPK inhibitor",0.43413,1.14,0.293,427,0.713,"talmapimod, CMPD.1, SB.239063, skepinone.l",0.533132379645891,0.146910470148134,FALSE +"H2126","Pearson.est","PARP inhibitor",0.44848,1.19,0.253,319,0.705,"olaparib, AZD2461, talazoparib, PJ.34, niraparib",0.596879478824182,0.151810883008601,FALSE +"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.2839,0.738,0.757,170,0.879,"dovitinib, regorafenib, ponatinib, masitinib, sorafenib",0.120904120499927,0.0560111249262281,FALSE +"H2126","Pearson.est","phosphatase inhibitor",0.25329,0.674,0.875,49,0.892,"sodium.stibogluconate",0.0579919469776868,0.0496351456238769,FALSE +"H2126","Pearson.est","phosphodiesterase inhibitor",-0.30276,-0.782,0.712,1276,0.871,"avanafil, anagrelide",0.147520006363144,0.0599818449923368,FALSE +"H2126","Pearson.est","PI3K inhibitor",0.27009,0.697,0.798,486,0.911,"buparlisib, PI.103, SB.2343, CH5132799, PI3K.IN.2, GDC.0980, GDC.0941, BGT226, NVP.BEZ235, ZSTK.474, idelalisib, PKI.179, PF.04691502, alpelisib",0.0979971086492706,0.0404816230270017,FALSE +"H2126","Pearson.est","PLK inhibitor",0.81496,2.16,0,177,0.0358,"GW.843682X, HMN.214, volasertib, NMS.1286937, GSK461364, BI.2536",Inf,1.44611697335613,TRUE +"H2126","Pearson.est","potassium channel blocker",-0.70184,-1.82,0.015,1044,0.298,"dofetilide, oleoylethanolamide, ibutilide, ML133, mepivacaine",1.82390874094432,0.525783735923745,FALSE +"H2126","Pearson.est","PPAR receptor agonist",-0.52648,-1.36,0.157,996,0.596,"fenofibrate, pterostilbene, oleoylethanolamide, clofibrate, S26948, GW.501516",0.804100347590766,0.224753740259764,FALSE +"H2126","Pearson.est","progesterone receptor agonist",0.31993,0.837,0.638,282,0.856,"nomegestrol.acetate, melengestrol.acetate",0.195179321278838,0.0675262353228468,FALSE +"H2126","Pearson.est","proteasome inhibitor",0.59609,1.59,0.0681,81,0.417,"MG.132, delanzomib",1.16685288808721,0.379863945026242,FALSE +"H2126","Pearson.est","protein synthesis inhibitor",0.36333,0.966,0.479,406,0.737,"clofoctol, cycloheximide, chloramphenicol.palmitate, thiostrepton, mercaptopurine, puromycin, methacycline",0.319664486585437,0.132532512140949,FALSE +"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.48308,-1.21,0.245,1070,0.683,"rheochrysidin, AV.412, BMS.599626, CP.724714",0.610833915635468,0.165579296318467,FALSE +"H2126","Pearson.est","RAF inhibitor",0.48312,1.24,0.22,326,0.773,"RAF265, SB.590885, regorafenib, sorafenib, vemurafenib, PLX.4720",0.657577319177794,0.111820506081675,FALSE +"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.48254,1.29,0.176,170,0.734,"regorafenib, sorafenib",0.75448733218585,0.134303940083929,FALSE +"H2126","Pearson.est","retinoid receptor agonist",0.67349,1.78,0.0219,230,0.243,"adapalene, tamibarotene, LE.135",1.65955588515988,0.614393726401688,TRUE +"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.54411,1.46,0.114,291,0.514,"hydroxyurea, cladribine, cytarabine, triapine, fludarabine.phosphate",0.943095148663527,0.289036881004724,FALSE +"H2126","Pearson.est","serotonin receptor agonist",-0.76611,-2,0.00738,1447,0.135,"aripiprazole",2.13194363817696,0.869666231504994,TRUE +"H2126","Pearson.est","serotonin receptor antagonist",-0.43681,-1.13,0.316,1447,0.624,"aripiprazole",0.500312917381596,0.204815410317576,FALSE +"H2126","Pearson.est","sodium channel blocker",0.28691,0.752,0.725,88,0.884,"brivaracetam, benzocaine",0.139661993429006,0.0535477349869269,FALSE +"H2126","Pearson.est","src inhibitor",-0.46277,-1.19,0.26,1076,0.677,"PP.1, TG.100572, bosutinib, PP.2, ZM.306416",0.585026652029182,0.169411331314856,FALSE +"H2126","Pearson.est","sterol demethylase inhibitor",0.69175,1.84,0.0249,166,0.213,"chlormidazole, lanoconazole, sulconazole",1.60380065290426,0.671620396561262,TRUE +"H2126","Pearson.est","TGF beta receptor inhibitor",-0.71089,-1.8,0.00722,1385,0.233,"SB.431542, SB.525334, repsox",2.14146280243036,0.632644078973981,TRUE +"H2126","Pearson.est","thymidylate synthase inhibitor",0.23133,0.597,0.908,398,0.948,"raltitrexed, ftorafur, trifluridine",0.0419141514789149,0.0231916626619338,FALSE +"H2126","Pearson.est","topoisomerase inhibitor",0.65131,1.7,0.0523,420,0.308,"mitoxantrone, topotecan, amsacrine, etoposide.phosphate, doxorubicin, exatecan.mesylate, idarubicin, dexrazoxane, genz.644282, TAS.103, epirubicin, nemorubicin, etoposide, voreloxin, rubitecan, SN.38, daunorubicin, beta.lapachone, amonafide, irinotecan, valrubicin",1.28149831113273,0.511449283499556,FALSE +"H2126","Pearson.est","tubulin polymerization inhibitor",0.46017,1.19,0.253,549,0.705,"BNC105, mebendazole, taltobulin, verubulin, vinblastine, fenbendazole, oxibendazole, albendazole, podophyllotoxin, flubendazole, indibulin, paclitaxel, vinorelbine, dolastatin.10, ABT.751, epothilone.b, vindesine, vincristine, docetaxel",0.596879478824182,0.151810883008601,FALSE +"H2126","Pearson.est","tyrosine kinase inhibitor",-0.26691,-0.683,0.833,1070,0.874,"rheochrysidin, tyrphostin.AG.99, UNC2250, AV.412, AMG.208, BMS.599626, vandetanib, GTP.14564, CP.724714",0.0793549985932124,0.058488567365597,FALSE +"H2126","Pearson.est","VEGFR inhibitor",0.21094,0.555,0.952,206,0.952,"RAF265, dovitinib, regorafenib, OSI.930, tivozanib, sorafenib, foretinib",0.0213630516155257,0.0213630516155257,FALSE +"H2126","Pearson.est","vitamin D receptor agonist",-0.5807,-1.48,0.0934,1222,0.578,"alfacalcidol, tacalcitol, paricalcitol",1.02965312376991,0.238072161579471,FALSE +"H3255","Pearson.est","EGFR inhibitor",-0.51478,-1.27,0.21,1073,0.534,"GW.583340, XL.647, BMS.690514, CP.724714, tucatinib, vandetanib, tyrphostin.AG.1478, BMS.599626, gefitinib, AEE788, neratinib, TAK.285, lapatinib, PD.168393, WZ8040, PD.153035, OSI.420, canertinib, icotinib, afatinib, pelitinib, osimertinib, BIBU.1361, erlotinib",0.677780705266081,0.272458742971444,FALSE +"H3255","Pearson.est","Abl kinase inhibitor",0.2923,0.746,0.739,286,0.898,"ponatinib, dasatinib, flumatinib, GZD824, ZM.306416",0.131355561605174,0.0467236633326956,FALSE +"H3255","Pearson.est","acetylcholine receptor agonist",0.46189,1.22,0.252,168,1,"xanomeline, nicotine",0.598599459218456,0,FALSE +"H3255","Pearson.est","acetylcholine receptor antagonist",-0.25234,-0.644,0.883,1379,0.961,"diphemanil",0.0540392964224314,0.0172766123314547,FALSE +"H3255","Pearson.est","adenosine receptor antagonist",-0.46757,-1.15,0.304,997,0.654,"PSB.1115, SCH.58261, MRS.1220, CGS.15943",0.517126416391246,0.184422251675733,FALSE +"H3255","Pearson.est","adrenergic receptor agonist",-0.20926,-0.53,0.964,1027,0.968,"A61603, isoxsuprine, clenbuterol, oxymetazoline, epinephrine",0.0159229660971692,0.0141246426916063,FALSE +"H3255","Pearson.est","adrenergic receptor antagonist",-0.32136,-0.803,0.708,1206,0.936,"pindolol, RS.17053, vincamine, levobunolol, carvedilol, dronedarone",0.149966742310231,0.0287241512618947,FALSE +"H3255","Pearson.est","AKT inhibitor",-0.43141,-1.07,0.374,1094,0.73,"GDC.0068, uprosertib, CCT128930, triciribine, palomid.529",0.42712839779952,0.136677139879544,FALSE +"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.36462,-0.903,0.568,1142,0.904,"CEP.37440, AZD3463, NVP.TAE684",0.245651664288981,0.0438315695246367,FALSE +"H3255","Pearson.est","androgen receptor antagonist",0.343,0.918,0.527,243,0.891,"RU.58841, enzalutamide",0.278189384787453,0.0501222959631252,FALSE +"H3255","Pearson.est","antioxidant",0.45576,1.2,0.237,18,0.976,"trolox",0.625251653989896,0.0105501823333082,FALSE +"H3255","Pearson.est","AP inhibitor",-0.43916,-1.09,0.374,1182,0.719,"tanshinone.i, GDC.0152, LCL.161",0.42712839779952,0.143271109617117,FALSE +"H3255","Pearson.est","ATPase inhibitor",0.63251,1.69,0.045,293,0.658,"k.strophanthidin, oligomycin.a, evodiamine, digoxin, NMS.873, blebbistatin....",1.34678748622466,0.181774106386044,FALSE +"H3255","Pearson.est","Aurora kinase inhibitor",0.39087,1,0.426,324,0.915,"AT.9283, CYC116, barasertib.HQPA, SNS.314, CCT129202, TAK.901, aurora.a.inhibitor.i, barasertib, ENMD.2076",0.370590400897281,0.0385789059335517,FALSE +"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.3125,0.844,0.628,258,1,"josamycin, radezolid, valnemulin, tilmicosin",0.202040356262804,0,FALSE +"H3255","Pearson.est","bacterial DNA gyrase inhibitor",-0.22987,-0.577,0.933,1024,0.979,"novobiocin, sarafloxacin, trovafloxacin",0.0301183562535,0.00921730819686218,FALSE +"H3255","Pearson.est","BCL inhibitor",0.3904,1.04,0.376,389,0.878,"ABT.737, gossypol, TW.37, obatoclax, venetoclax",0.424812155072339,0.0565054840938974,FALSE +"H3255","Pearson.est","Bcr.Abl kinase inhibitor",0.30297,0.795,0.678,223,1,"ponatinib, dasatinib, flumatinib, GZD824",0.168770306132937,0,FALSE +"H3255","Pearson.est","benzodiazepine receptor agonist",-0.33509,-0.841,0.677,897,0.945,"indiplon, bentazepam, CGS.20625, ZK.93423, zaleplon",0.169411331314856,0.0245681914907371,FALSE +"H3255","Pearson.est","bromodomain inhibitor",-0.4036,-0.997,0.451,1203,0.744,"JQ1....",0.345823458122039,0.128427064454121,FALSE +"H3255","Pearson.est","calcium channel blocker",0.29499,0.783,0.714,291,0.947,"efonidipine.monoethanolate, carboxyamidotriazole, SR.33805",0.146301788223826,0.0236500209967266,FALSE +"H3255","Pearson.est","CC chemokine receptor antagonist",-0.27838,-0.71,0.796,1413,0.944,"navarixin",0.0990869322623309,0.025028005701931,FALSE +"H3255","Pearson.est","CDK inhibitor",-0.40192,-1.01,0.419,1185,0.745,"PHA.793887, BMS.387032, AZD5438, kenpaullone, alvocidib, arcyriaflavin.a",0.377785977033705,0.127843727251707,FALSE +"H3255","Pearson.est","CHK inhibitor",-0.52259,-1.32,0.132,968,0.497,"CHIR.124, SCH.900776, LY2606368, LY2603618",0.87942606879415,0.303643611266668,FALSE +"H3255","Pearson.est","cyclooxygenase inhibitor",-0.26442,-0.655,0.858,868,0.991,"curcumin, amfenac, acetylsalicylsalicylic.acid, aspirin, meloxicam, FR.122047, suxibuzone, indoprofen, ramifenazone, AM.404, FK.3311",0.0665127121512946,0.00392634551472468,FALSE +"H3255","Pearson.est","cytochrome P450 inhibitor",0.46194,1.25,0.205,358,1,"metyrapone, eplerenone, itraconazole, morin",0.688246138944246,0,FALSE +"H3255","Pearson.est","DNA alkylating agent",-0.41616,-1.03,0.433,1307,0.785,"mitomycin.c, ifosfamide, melphalan, dacarbazine",0.363512103646635,0.105130343254747,FALSE +"H3255","Pearson.est","DNA inhibitor",-0.26495,-0.654,0.89,1014,0.97,"valrubicin, sangivamycin, bendamustine, nithiamide, busulfan, primaquine, melphalan",0.0506099933550872,0.0132282657337552,FALSE +"H3255","Pearson.est","DNA methyltransferase inhibitor",-0.7504,-1.9,0.0085,1344,0.248,"SGI.1027, fdcyd, azacitidine",2.07058107428571,0.605548319173784,TRUE +"H3255","Pearson.est","DNA polymerase inhibitor",0.28615,0.756,0.716,360,0.917,"famciclovir, adefovir.dipivoxil, foscarnet",0.145086977692144,0.0376306643299789,FALSE +"H3255","Pearson.est","DNA synthesis inhibitor",-0.34415,-0.871,0.58,949,0.914,"capecitabine, enocitabine, cyclocytidine, estramustine.phosphate, anisomycin, altretamine, mitomycin.c, floxuridine",0.236572006437063,0.0390538042661686,FALSE +"H3255","Pearson.est","dopamine receptor antagonist",0.24463,0.653,0.872,270,0.963,"thioproperazine, remoxipride, clebopride, domperidone, nemonapride, raclopride",0.0594835150674328,0.0163737128754655,FALSE +"H3255","Pearson.est","estrogen receptor agonist",0.4263,1.13,0.296,406,0.875,"estrone, erteberel, levonorgestrel, estradiol.cypionate, ethinyl.estradiol",0.528708288941061,0.0579919469776868,FALSE +"H3255","Pearson.est","estrogen receptor antagonist",0.39171,1.04,0.405,107,0.878,"tamoxifen",0.392544976785331,0.0565054840938974,FALSE +"H3255","Pearson.est","FGFR inhibitor",0.34743,0.932,0.531,253,0.962,"erdafitinib, nintedanib, AZD4547, lenvatinib",0.274905478918531,0.0168249279621871,FALSE +"H3255","Pearson.est","FLT3 inhibitor",0.2219,0.594,0.918,370,0.99,"tyrphostin.AG.1296, ponatinib, GTP.14564, TG.101348, ENMD.2076, gilteritinib",0.0371573187987575,0.00436480540245009,FALSE +"H3255","Pearson.est","glucocorticoid receptor agonist",0.61621,1.65,0.0463,91,0.529,"hydrocortisone, beclomethasone.dipropionate, dexamethasone.acetate, triamcinolone, desonide, fluticasone.propionate, halcinonide, piretanide",1.33441900898205,0.276544327964814,FALSE +"H3255","Pearson.est","glutamate receptor antagonist",-0.49291,-1.22,0.246,1313,0.601,"diazooxonorleucine, MTPG, ACDPP",0.609064892896621,0.22112552799726,FALSE +"H3255","Pearson.est","glycogen synthase kinase inhibitor",-0.55557,-1.38,0.13,1202,0.554,"GSK.3.inhibitor.IX, LY2090314, kenpaullone, AZD2858",0.886056647693163,0.25649023527157,FALSE +"H3255","Pearson.est","growth factor receptor inhibitor",-0.36284,-0.892,0.579,1017,0.898,"GSK1838705A, AZD3463, GW.441756",0.237321436272564,0.0467236633326956,FALSE +"H3255","Pearson.est","HCV inhibitor",-0.56102,-1.4,0.125,1321,0.61,"PSI.7976, daclatasvir",0.903089986991944,0.214670164989233,FALSE +"H3255","Pearson.est","HDAC inhibitor",-0.57408,-1.44,0.109,1114,1,"AR.42, vorinostat, M.344, givinostat, nexturastat.a, chidamide, entinostat, romidepsin, tacedinaline, PCI.24781, R306465, panobinostat, JNJ.26481585, SB.939",0.962573502059376,0,FALSE +"H3255","Pearson.est","histamine receptor antagonist",-0.57235,-1.43,0.122,1156,0.89,"levocetirizine, astemizole, ranitidine, terfenadine, tecastemizole, cyproheptadine, chloropyramine, zolantidine",0.913640169325252,0.0506099933550872,FALSE +"H3255","Pearson.est","HMGCR inhibitor",0.30595,0.825,0.624,296,0.993,"lovastatin, atorvastatin",0.204815410317576,0.00305075150461883,FALSE +"H3255","Pearson.est","HSP inhibitor",-0.55124,-1.36,0.161,1010,0.555,"VER.49009, BIIB021, SNX.2112, PU.H71, NVP.AUY922, tanespimycin, alvespimycin, SNX.5422, XL888",0.79317412396815,0.255707016877324,FALSE +"H3255","Pearson.est","JAK inhibitor",0.2023,0.529,0.975,74,0.97,"AT.9283, filgotinib",0.0109953843014632,0.0132282657337552,FALSE +"H3255","Pearson.est","KIT inhibitor",-0.31777,-0.792,0.691,860,0.909,"sunitinib, imatinib, motesanib, vatalanib, OSI.930, regorafenib, telatinib, tandutinib",0.160521952625802,0.0414361167780325,FALSE +"H3255","Pearson.est","MDM inhibitor",0.28387,0.773,0.745,66,0.925,"AMG.232",0.127843727251707,0.0338582672609674,FALSE +"H3255","Pearson.est","MEK inhibitor",0.29911,0.793,0.702,134,0.969,"PD.318088, MEK1.2.inhibitor, refametinib",0.153662887870195,0.0136762229492347,FALSE +"H3255","Pearson.est","MET inhibitor",-0.5637,-1.39,0.14,1013,0.581,"NVP.BVU972, AMG458, INC.280",0.853871964321762,0.235823867609669,FALSE +"H3255","Pearson.est","microtubule inhibitor",-0.32808,-0.823,0.69,935,0.951,"cabazitaxel, vinflunine, estramustine.phosphate, D.64131, podophyllotoxin",0.161150909262745,0.0218194830625861,FALSE +"H3255","Pearson.est","mTOR inhibitor",0.35704,0.936,0.509,318,1,"torin.1, OSI.027, WYE.354, SB.2343, PF.04691502, WYE.125132, AZD2014, PKI.179, XL388, LY3023414, voxtalisib, MLN0128",0.293282217663241,0,FALSE +"H3255","Pearson.est","NFkB pathway inhibitor",0.44904,1.18,0.239,59,0.829,"EVP4593, tyloxapol",0.621602099051862,0.0814454694497265,FALSE +"H3255","Pearson.est","opioid receptor agonist",-0.46758,-1.16,0.273,1409,0.693,"salvinorin.a",0.563837352959244,0.159266765388193,FALSE +"H3255","Pearson.est","p38 MAPK inhibitor",-0.55788,-1.41,0.112,1058,0.73,"TAK.715, SB.239063, VX.702, CMPD.1",0.950781977329818,0.136677139879544,FALSE +"H3255","Pearson.est","PARP inhibitor",-0.59878,-1.52,0.0675,1216,0.865,"talazoparib, olaparib, niraparib, PJ.34",1.17069622716898,0.0629838925351858,FALSE +"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.21319,0.554,0.97,253,0.987,"nintedanib, linifanib, axitinib, ponatinib, dasatinib, lenvatinib",0.0132282657337552,0.00568284733036327,FALSE +"H3255","Pearson.est","phosphatase inhibitor",-0.25989,-0.643,0.877,1108,0.942,"mycophenolate.mofetil, AS.1949490, sodium.stibogluconate",0.0570004066339595,0.0259490972071227,FALSE +"H3255","Pearson.est","phosphodiesterase inhibitor",-0.54754,-1.35,0.143,1074,0.536,"trequinsin, GSK256066, EMD.53998, papaverine, YM.976, zardaverine, cilostamide",0.844663962534938,0.27083521030723,FALSE +"H3255","Pearson.est","PI3K inhibitor",0.27867,0.719,0.768,313,0.907,"GDC.0941, SB.2343, PF.04691502, ZSTK.474, buparlisib, PKI.179, LY3023414, voxtalisib",0.114638779968488,0.0423927129399047,FALSE +"H3255","Pearson.est","PLK inhibitor",-0.57657,-1.4,0.121,1011,0.61,"HMN.214, GSK461364, BI.2536",0.91721462968355,0.214670164989233,FALSE +"H3255","Pearson.est","potassium channel blocker",-0.40357,-1.01,0.453,1175,0.745,"meglitinide, oleoylethanolamide",0.343901797987168,0.127843727251707,FALSE +"H3255","Pearson.est","PPAR receptor agonist",0.44848,1.23,0.208,34,1,"fenofibrate, clofibrate",0.681936665037238,0,FALSE +"H3255","Pearson.est","progesterone receptor agonist",0.63677,1.76,0.0338,248,0.957,"tanaproget, norethindrone, nomegestrol.acetate, norgestrel",1.47108329972235,0.0190880622231565,FALSE +"H3255","Pearson.est","proteasome inhibitor",-0.69441,-1.75,0.013,1057,0.404,"MG.132, ONX.0914, carfilzomib, delanzomib, bortezomib, ixazomib, ixazomib.citrate",1.88605664769316,0.393618634889395,FALSE +"H3255","Pearson.est","protein synthesis inhibitor",-0.28992,-0.715,0.821,1124,0.959,"brefeldin.a, puromycin, homoharringtonine, azomycin..2.nitroimidazole., emetine",0.0856568428805592,0.0181813928293364,FALSE +"H3255","Pearson.est","protein tyrosine kinase inhibitor",0.35105,0.918,0.538,113,0.891,"mubritinib, PP.121",0.269217724333611,0.0501222959631252,FALSE +"H3255","Pearson.est","RAF inhibitor",-0.53213,-1.32,0.18,1076,0.497,"regorafenib, SB.590885, vemurafenib, LGX818, dabrafenib, CEP.32496, GDC.0879",0.744727494896694,0.303643611266668,FALSE +"H3255","Pearson.est","RET tyrosine kinase inhibitor",-0.52575,-1.29,0.194,1076,0.524,"regorafenib, vandetanib, apatinib",0.712198270069774,0.280668713016273,FALSE +"H3255","Pearson.est","retinoid receptor agonist",-0.56665,-1.42,0.096,1235,0.797,"tamibarotene, adarotene, AM.580, CD.437",1.01772876696043,0.0985416786038876,FALSE +"H3255","Pearson.est","ribonucleotide reductase inhibitor",-0.41084,-1.02,0.409,1132,0.777,"gemcitabine, fludarabine.phosphate, clofarabine, fludarabine",0.388276691992658,0.109578981199086,FALSE +"H3255","Pearson.est","serotonin receptor agonist",0.45599,1.19,0.259,133,0.894,"zolmitriptan, aripiprazole",0.586700235918748,0.0486624812040823,FALSE +"H3255","Pearson.est","serotonin receptor antagonist",-0.32401,-0.812,0.679,1077,0.945,"RS.16566, sertindole, ziprasidone, SB.228357",0.168130225719498,0.0245681914907371,FALSE +"H3255","Pearson.est","sodium channel blocker",0.41085,1.09,0.326,84,0.895,"oxcarbazepine, benzethonium, cibenzoline",0.486782399932061,0.048176964684088,FALSE +"H3255","Pearson.est","src inhibitor",-0.28932,-0.739,0.774,950,0.946,"PP.2, TG.100572, saracatinib, KX2.391",0.111259039317107,0.0241088635982073,FALSE +"H3255","Pearson.est","sterol demethylase inhibitor",0.62176,1.64,0.064,105,0.412,"sulconazole, posaconazole, terconazole",1.19382002601611,0.385102783966865,FALSE +"H3255","Pearson.est","TGF beta receptor inhibitor",-0.32393,-0.801,0.717,1160,0.916,"D.4476, LY2109761",0.1444808443322,0.0381045263321496,FALSE +"H3255","Pearson.est","thymidylate synthase inhibitor",-0.69308,-1.72,0.0149,1324,0.347,"carmofur, raltitrexed, doxifluridine",1.82681373158773,0.459670525209126,FALSE +"H3255","Pearson.est","topoisomerase inhibitor",-0.53436,-1.33,0.161,1220,0.543,"topotecan, nemorubicin, licochalcone.a, irinotecan, rubitecan, SN.38, camptothecin, genz.644282, exatecan.mesylate",0.79317412396815,0.265200170411153,FALSE +"H3255","Pearson.est","tubulin polymerization inhibitor",-0.45552,-1.15,0.285,805,0.654,"oxibendazole, ABT.751, indibulin, flubendazole, BNC105, epothilone.b, CYT.997, vinorelbine, dolastatin.10, vincristine, parbendazole, albendazole, plinabulin, mebendazole, fosbretabulin, KX2.391, podophyllotoxin, taltobulin, combretastatin.A.4",0.54515513999149,0.184422251675733,FALSE +"H3255","Pearson.est","tyrosine kinase inhibitor",-0.30393,-0.757,0.77,1135,0.941,"CP.724714, AV.412, tyrphostin.A9, vandetanib, tivantinib, BMS.599626, apatinib, AMG.208, bafetinib",0.113509274827518,0.0264103765727431,FALSE +"H3255","Pearson.est","VEGFR inhibitor",-0.21744,-0.545,0.964,946,0.979,"motesanib, foretinib, vatalanib, RAF265, OSI.930, regorafenib, XL.647, TG.100572, BMS.690514, telatinib, golvatinib, MGCD.265, vandetanib, lucitanib, AEE788, orantinib",0.0159229660971692,0.00921730819686218,FALSE +"H3255","Pearson.est","vitamin D receptor agonist",-0.44314,-1.11,0.316,1198,0.706,"maxacalcitol, calcitriol, ercalcitriol",0.500312917381596,0.151195298948196,FALSE +"H358","Pearson.est","EGFR inhibitor",-0.51398,-1.3,0.196,1045,0.548,"PD.168393, CP.724714, BMS.690514, ARRY.334543, AEE788, OSI.420, vandetanib, tucatinib, BMS.599626, rociletinib, GW.583340, BIBU.1361, PD.153035, canertinib, erlotinib, dacomitinib, TAK.285, tyrphostin.AG.1478, icotinib, WZ8040, neratinib, lapatinib, gefitinib, osimertinib, pelitinib, afatinib",0.707743928643524,0.261219441515631,FALSE +"H358","Pearson.est","Abl kinase inhibitor",0.22552,0.594,0.913,357,1,"ponatinib, ZM.306416, flumatinib, GZD824, dasatinib",0.039529222465701,0,FALSE +"H358","Pearson.est","acetylcholine receptor agonist",0.56475,1.53,0.0916,367,0.641,"xanomeline, nefiracetam",1.03810452633215,0.193141970481183,FALSE +"H358","Pearson.est","acetylcholine receptor antagonist",-0.4512,-1.14,0.298,1412,0.586,"dicycloverine",0.525783735923745,0.232102383981909,FALSE +"H358","Pearson.est","adenosine receptor antagonist",-0.51285,-1.3,0.173,1071,0.548,"sulmazole, theophylline, CGS.15943",0.761953896871205,0.261219441515631,FALSE +"H358","Pearson.est","adrenergic receptor agonist",-0.47938,-1.23,0.224,944,0.561,"midodrine, methyldopa, epinephrine, norepinephrine, oxymetazoline, metaraminol, terbutaline, clenbuterol, A61603, isoxsuprine",0.649751981665837,0.251037138743839,FALSE +"H358","Pearson.est","adrenergic receptor antagonist",-0.34512,-0.87,0.624,1295,0.857,"pindolol, vincamine, levobunolol, dronedarone",0.204815410317576,0.0670191780768018,FALSE +"H358","Pearson.est","AKT inhibitor",-0.47207,-1.18,0.249,1007,0.581,"GDC.0068, GSK2110183, CCT128930, ONC201, palomid.529, triciribine, uprosertib",0.603800652904264,0.235823867609669,FALSE +"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.26444,0.708,0.804,1068,1,"alectinib, brigatinib, SB.505124, DMH1, AZD3463, lorlatinib, NVP.TAE684, AP26113, GW.788388, CEP.37440, crizotinib",0.0947439512515487,0,FALSE +"H358","Pearson.est","androgen receptor antagonist",-0.28281,-0.727,0.807,760,0.957,"flutamide, enzalutamide, nilutamide, bicalutamide, cyproterone.acetate",0.0931264652779296,0.0190880622231565,FALSE +"H358","Pearson.est","antioxidant",0.5127,1.39,0.135,14,0.696,"trolox",0.869666231504994,0.157390760389438,FALSE +"H358","Pearson.est","AP inhibitor",-0.46805,-1.19,0.261,989,0.613,"GDC.0152, tanshinone.i, LCL.161, embelin",0.583359492661719,0.212539525481585,FALSE +"H358","Pearson.est","ATPase inhibitor",0.70154,1.89,0.0148,83,0.151,"k.strophanthidin, NMS.873, oligomycin.a, blebbistatin....",1.82973828460504,0.821023052706831,TRUE +"H358","Pearson.est","Aurora kinase inhibitor",0.21701,0.584,0.93,482,0.999,"CYC116, CCT129202, AT.9283, barasertib.HQPA, PHA.680632, ENMD.2076, CCT137690, TAK.901, GSK1070916, SNS.314, danusertib, KW.2449",0.0315170514460649,0.000434511774017692,FALSE +"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.29645,0.826,0.657,26,1,"radezolid",0.182434630440219,0,FALSE +"H358","Pearson.est","bacterial DNA gyrase inhibitor",-0.35459,-0.87,0.62,1113,0.857,"sarafloxacin, lomefloxacin, sparfloxacin, trovafloxacin",0.207608310501746,0.0670191780768018,FALSE +"H358","Pearson.est","BCL inhibitor",0.27847,0.753,0.741,1047,1,"gossypol, ABT.737, TW.37, venetoclax, HA14.1, oridonin, navitoclax, obatoclax",0.130181792020672,0,FALSE +"H358","Pearson.est","Bcr.Abl kinase inhibitor",-0.20044,-0.503,0.979,1139,0.997,"metatinib, tozasertib, imatinib",0.00921730819686218,0.00130484168834428,FALSE +"H358","Pearson.est","benzodiazepine receptor agonist",-0.25642,-0.647,0.895,803,1,"eprinomectin, ZK.93423, temazepam, CGS.20625, indiplon, zaleplon",0.048176964684088,0,FALSE +"H358","Pearson.est","bromodomain inhibitor",-0.65874,-1.62,0.0381,1179,0.528,"bromosporine, I.BET151, JQ1...., I.BET.762",1.41907502432438,0.277366077466188,FALSE +"H358","Pearson.est","calcium channel blocker",0.28589,0.775,0.715,308,1,"efonidipine.monoethanolate, carboxyamidotriazole, pranidipine, cinnarazine",0.145693958198919,0,FALSE +"H358","Pearson.est","CC chemokine receptor antagonist",-0.30267,-0.759,0.748,1115,0.978,"PF.04136309, MK.0812, navarixin",0.126098402135539,0.00966114521239857,FALSE +"H358","Pearson.est","CDK inhibitor",-0.38777,-0.98,0.453,1097,0.767,"AZD5438, dinaciclib, P276.00, BMS.387032, kenpaullone, PHA.793887, arcyriaflavin.a, alvocidib, CR8..R.",0.343901797987168,0.115204636051019,FALSE +"H358","Pearson.est","CHK inhibitor",-0.55031,-1.39,0.126,793,0.656,"SB.218078, AZD7762, PF.477736, CHIR.124, LY2603618, SCH.900776, LY2606368",0.899629454882437,0.18309616062434,FALSE +"H358","Pearson.est","cyclooxygenase inhibitor",0.20353,0.532,0.959,188,0.968,"pterostilbene, tepoxalin, phenylbutazone, sulfasalazine",0.0181813928293364,0.0141246426916063,FALSE +"H358","Pearson.est","cytochrome P450 inhibitor",0.23441,0.627,0.903,339,1,"eplerenone, morin, PF.4981517",0.0443122496864942,0,FALSE +"H358","Pearson.est","DNA alkylating agent",-0.57136,-1.45,0.0895,1128,0.632,"mitomycin.c, dianhydrogalactitol, ifosfamide, estramustine, satraplatin, cisplatin, melphalan, dacarbazine",1.04817696468409,0.199282921717615,FALSE +"H358","Pearson.est","DNA inhibitor",0.29353,0.803,0.651,185,1,"carboplatin, oxaliplatin, mechlorethamine, metronidazole, teroxirone",0.186419011431808,0,FALSE +"H358","Pearson.est","DNA methyltransferase inhibitor",-0.72291,-1.84,0.0111,1426,0.454,"fdcyd, azacitidine",1.95467702121334,0.342944147142896,FALSE +"H358","Pearson.est","DNA polymerase inhibitor",-0.53429,-1.34,0.143,897,0.619,"adefovir.dipivoxil, cephalomannine, trifluridine, cidofovir",0.844663962534938,0.208309350979882,FALSE +"H358","Pearson.est","DNA synthesis inhibitor",-0.2998,-0.752,0.779,1128,0.965,"mitomycin.c, floxuridine, altretamine, cisplatin",0.108462542327436,0.0154726866562074,FALSE +"H358","Pearson.est","dopamine receptor antagonist",-0.23834,-0.59,0.936,1194,0.986,"amisulpride, sertindole, acetophenazine, isofloxythepin",0.0287241512618947,0.0061230850587888,FALSE +"H358","Pearson.est","estrogen receptor agonist",-0.33789,-0.86,0.639,1174,0.852,"equol, estradiol, PPT",0.1944991418416,0.0695604052332999,FALSE +"H358","Pearson.est","estrogen receptor antagonist",-0.28098,-0.696,0.816,1047,0.978,"toremifene, raloxifene",0.0883098412461389,0.00966114521239857,FALSE +"H358","Pearson.est","FGFR inhibitor",0.42861,1.15,0.269,119,0.734,"AZD4547, nintedanib, erdafitinib",0.570247719997592,0.134303940083929,FALSE +"H358","Pearson.est","FLT3 inhibitor",-0.21741,-0.546,0.963,1345,0.997,"tandutinib, pacritinib",0.0163737128754655,0.00130484168834428,FALSE +"H358","Pearson.est","glucocorticoid receptor agonist",0.71496,1.92,0.00767,139,0.381,"hydrocortisone, beclomethasone.dipropionate, dexamethasone.acetate, desonide, triamcinolone.acetonide, halcinonide, flumethasone.pivalate, rimexolone, triamcinolone, fluticasone.propionate, ciclesonide, fluocinolone.acetonide, deflazacort, betamethasone, clobetasol.propionate",2.11520463605102,0.419075024324381,FALSE +"H358","Pearson.est","glutamate receptor antagonist",-0.41884,-1.06,0.394,1336,0.642,"ACDPP, LY456236, diazooxonorleucine",0.404503778174426,0.192464971931147,FALSE +"H358","Pearson.est","glycogen synthase kinase inhibitor",-0.55724,-1.39,0.123,1275,0.656,"kenpaullone, GSK.3.inhibitor.IX, AZD2858",0.910094888560602,0.18309616062434,FALSE +"H358","Pearson.est","growth factor receptor inhibitor",0.42628,1.16,0.272,500,0.779,"PHA.848125, GSK1904529A, lestaurtinib, danusertib, GSK1838705A",0.565431095965801,0.108462542327436,FALSE +"H358","Pearson.est","HCV inhibitor",-0.62047,-1.55,0.068,1221,0.444,"daclatasvir, PSI.7976, embelin, Ro.9187",1.16749108729376,0.35261702988538,FALSE +"H358","Pearson.est","HDAC inhibitor",-0.48952,-1.27,0.195,1052,0.574,"dacinostat, trichostatin.a, givinostat, romidepsin, tacedinaline, M.344, entinostat, vorinostat, R306465, PCI.24781, panobinostat, SB.939, JNJ.26481585",0.709965388637482,0.241088107602027,FALSE +"H358","Pearson.est","histamine receptor antagonist",-0.5457,-1.35,0.166,1020,0.701,"cimetidine, cyproheptadine, lafutidine, astemizole, tecastemizole, terfenadine, tiotidine, levocetirizine, zolantidine, chloropyramine",0.779891911959945,0.154281982033341,FALSE +"H358","Pearson.est","HMGCR inhibitor",0.28127,0.747,0.769,374,1,"lovastatin, pitavastatin, atorvastatin",0.114073660198569,0,FALSE +"H358","Pearson.est","HSP inhibitor",-0.47492,-1.18,0.281,845,0.581,"SNX.5422, ganetespib, SNX.2112, PU.H71, tanespimycin, KW.2478, guanidine, BIIB021, alvespimycin, XL888, NVP.AUY922, VER.49009",0.55129368009492,0.235823867609669,FALSE +"H358","Pearson.est","JAK inhibitor",-0.34899,-0.878,0.597,1376,0.89,"pacritinib, LY2784544, atiprimod",0.224025668870631,0.0506099933550872,FALSE +"H358","Pearson.est","KIT inhibitor",-0.33649,-0.852,0.658,1233,0.844,"imatinib, telatinib, tandutinib",0.181774106386044,0.073657553374345,FALSE +"H358","Pearson.est","MDM inhibitor",0.71263,1.9,0.0131,416,0.214,"AMG.232, idasanutlin, nutlin.3, RITA, serdemetan",1.88272870434424,0.669586226650809,TRUE +"H358","Pearson.est","MEK inhibitor",-0.3513,-0.888,0.571,1436,0.897,"nobiletin, BIX.02188",0.243363891754152,0.0472075569559079,FALSE +"H358","Pearson.est","MET inhibitor",-0.71441,-1.78,0.0131,1126,0.369,"NVP.BVU972, LY2801653, AMG458, INC.280",1.88272870434424,0.43297363384094,FALSE +"H358","Pearson.est","microtubule inhibitor",0.29972,0.827,0.633,1017,1,"vinblastine, cytochalasin.b, estramustine.phosphate, vinflunine, secnidazole, colchicine, cabazitaxel, D.64131, podophyllotoxin, triclabendazole",0.198596289982645,0,FALSE +"H358","Pearson.est","mTOR inhibitor",0.28056,0.752,0.747,337,1,"SB.2343, torin.1, PF.04691502, AZD2014, MLN0128, XL388, WYE.125132, WYE.354, OSI.027, PKI.179",0.126679398184601,0,FALSE +"H358","Pearson.est","NFkB pathway inhibitor",0.23699,0.636,0.888,8,1,"EVP4593",0.051587034221399,0,FALSE +"H358","Pearson.est","opioid receptor agonist",-0.62567,-1.6,0.0499,1442,0.473,"salvinorin.a",1.30189945437661,0.325138859262188,FALSE +"H358","Pearson.est","p38 MAPK inhibitor",-0.52606,-1.34,0.151,981,0.619,"SB.239063, VX.702, CMPD.1, TAK.715",0.821023052706831,0.208309350979882,FALSE +"H358","Pearson.est","PARP inhibitor",-0.52088,-1.3,0.192,1012,0.548,"talazoparib, olaparib, PJ.34, niraparib",0.71669877129645,0.261219441515631,FALSE +"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.23695,-0.6,0.915,1343,1,"telatinib, tandutinib, trapidil",0.0385789059335517,0,FALSE +"H358","Pearson.est","phosphatase inhibitor",0.33856,0.89,0.562,74,1,"GSK2830371, bis.maltolato.oxovanadium.IV.",0.250263684430939,0,FALSE +"H358","Pearson.est","phosphodiesterase inhibitor",-0.47035,-1.17,0.297,1072,0.554,"EMD.53998, zardaverine, YM.976, cilostamide",0.527243550682788,0.25649023527157,FALSE +"H358","Pearson.est","PI3K inhibitor",-0.24952,-0.628,0.903,1197,1,"taselisib, AZD6482, PIK.75, CH5132799, TG.100713, pilaralisib, PF.05212384",0.0443122496864942,0,FALSE +"H358","Pearson.est","PLK inhibitor",0.49733,1.34,0.159,373,0.615,"NMS.1286937, volasertib, HMN.214, rigosertib",0.798602875679548,0.211124884224583,FALSE +"H358","Pearson.est","potassium channel blocker",-0.43773,-1.09,0.344,1056,0.609,"meglitinide, oleoylethanolamide, dofetilide",0.46344155742847,0.215382707367125,FALSE +"H358","Pearson.est","PPAR receptor agonist",0.49484,1.34,0.147,84,0.615,"fenofibrate, pterostilbene",0.832682665251824,0.211124884224583,FALSE +"H358","Pearson.est","progesterone receptor agonist",0.54969,1.45,0.121,37,0.677,"tanaproget, norethindrone",0.91721462968355,0.169411331314856,FALSE +"H358","Pearson.est","proteasome inhibitor",-0.67367,-1.7,0.0274,1092,0.432,"ONX.0914, ixazomib, ixazomib.citrate, bortezomib, carfilzomib",1.56224943717961,0.364516253185088,FALSE +"H358","Pearson.est","protein synthesis inhibitor",0.2181,0.587,0.928,121,1,"clindamycin.phosphate, clofoctol",0.0324520237811379,0,FALSE +"H358","Pearson.est","protein tyrosine kinase inhibitor",0.40412,1.1,0.329,88,0.776,"mubritinib, PP.121",0.482804102050026,0.110138278741812,FALSE +"H358","Pearson.est","RAF inhibitor",-0.50533,-1.32,0.178,881,0.619,"regorafenib, CEP.32496, SB.590885, AZ.628, GDC.0879, vemurafenib, dabrafenib",0.749579997691106,0.208309350979882,FALSE +"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.49647,-1.25,0.218,881,0.552,"regorafenib, sunitinib, vandetanib, apatinib",0.661543506395395,0.258060922270801,FALSE +"H358","Pearson.est","retinoid receptor agonist",-0.44912,-1.1,0.347,1310,0.612,"AM.580, tamibarotene, CD.437",0.459670525209126,0.213248577854439,FALSE +"H358","Pearson.est","ribonucleotide reductase inhibitor",0.27802,0.749,0.777,178,1,"cytarabine, pentostatin, hydroxyurea",0.109578981199086,0,FALSE +"H358","Pearson.est","serotonin receptor agonist",0.46064,1.24,0.237,73,0.674,"aripiprazole",0.625251653989896,0.17134010346468,FALSE +"H358","Pearson.est","serotonin receptor antagonist",-0.35959,-0.912,0.553,1192,0.876,"lerisetron, SB.228357, sertindole, RS.16566",0.257274868695302,0.0574958938319193,FALSE +"H358","Pearson.est","sodium channel blocker",0.30052,0.828,0.649,161,1,"oxcarbazepine, benzethonium, A.803467, cibenzoline",0.187755303199631,0,FALSE +"H358","Pearson.est","src inhibitor",-0.29084,-0.737,0.801,1266,0.964,"saracatinib, PP.2",0.0963674839157623,0.0159229660971692,FALSE +"H358","Pearson.est","sterol demethylase inhibitor",0.47098,1.29,0.177,370,0.639,"sulconazole, posaconazole, terconazole, chlormidazole",0.752026733638193,0.1944991418416,FALSE +"H358","Pearson.est","TGF beta receptor inhibitor",-0.49094,-1.25,0.223,1227,0.552,"D.4476, repsox, LY2109761",0.651695136951839,0.258060922270801,FALSE +"H358","Pearson.est","thymidylate synthase inhibitor",-0.61318,-1.55,0.0564,1039,0.444,"trifluridine, raltitrexed, carmofur, doxifluridine",1.24872089601666,0.35261702988538,FALSE +"H358","Pearson.est","topoisomerase inhibitor",-0.43851,-1.11,0.335,1263,0.617,"SN.38, camptothecin, irinotecan, licochalcone.a, genz.644282, exatecan.mesylate",0.474955192963155,0.209714835966758,FALSE +"H358","Pearson.est","tubulin polymerization inhibitor",0.21101,0.556,0.955,1000,0.986,"verubulin, vindesine, vinblastine, CYT.997, ABT.751, BNC105, mebendazole, dolastatin.10, fenbendazole, parbendazole, docetaxel, vincristine, indibulin, flubendazole, nocodazole, plinabulin, albendazole, vinorelbine, taltobulin, oxibendazole, epothilone.b, podophyllotoxin, fosbretabulin, paclitaxel, epothilone.d, KX2.391",0.0199966284162537,0.0061230850587888,FALSE +"H358","Pearson.est","tyrosine kinase inhibitor",-0.23646,-0.592,0.931,878,1,"tyrphostin.AG.99, regorafenib, bafetinib, rheochrysidin, sunitinib, CP.724714, tyrphostin.A9, vandetanib, BMS.599626, AV.412, apatinib, tivantinib, AMG.208",0.0310503190186574,0,FALSE +"H358","Pearson.est","VEGFR inhibitor",-0.19149,-0.479,0.988,873,0.985,"cediranib, regorafenib, XL.647, vatalanib, MK.2461, foretinib, sunitinib, BMS.690514, orantinib, AEE788, lucitanib, vandetanib, golvatinib, telatinib, MGCD.265",0.00524305541237188,0.00656376950238827,FALSE +"H358","Pearson.est","vitamin D receptor agonist",-0.46559,-1.17,0.278,1215,0.554,"maxacalcitol, ercalcitriol, calcitriol",0.555955204081924,0.25649023527157,FALSE +"A549","Pearson.est","EGFR inhibitor",0.69799,1.75,0.0167,139,0.584,"pelitinib, dacomitinib, tucatinib, AZD8931, osimertinib, afatinib, CP.724714, WZ8040, canertinib, OSI.420, gefitinib, AEE788, poziotinib, icotinib, neratinib, erlotinib, ARRY.334543, BMS.690514, AST.1306, BMS.599626, vandetanib",1.77728352885242,0.233587152887601,FALSE +"A549","Pearson.est","Abl kinase inhibitor",0.3852,0.963,0.489,177,0.782,"ZM.306416, imatinib, flumatinib",0.31069114087638,0.106793246940152,FALSE +"A549","Pearson.est","acetylcholine receptor agonist",-0.33589,-0.877,0.586,1366,0.866,"nicotine",0.232102383981909,0.0624821079826534,FALSE +"A549","Pearson.est","acetylcholine receptor antagonist",0.61234,1.52,0.0719,565,0.585,"dicycloverine, darifenacin, hyoscyamine, diphemanil, methscopolamine, iododexetimide",1.14327110961712,0.23284413391782,FALSE +"A549","Pearson.est","adenosine receptor antagonist",0.6438,1.66,0.0373,496,0.497,"CGS.15943, MRS.1220, SCH.58261, istradefylline, sulmazole, PSB.1115",1.42829116819131,0.303643611266668,FALSE +"A549","Pearson.est","adrenergic receptor agonist",0.39275,1.01,0.442,406,0.826,"oxymetazoline, methyldopa, A61603, isoxsuprine, isoetharine, clenbuterol, xylazine",0.354577730650908,0.0830199526796178,FALSE +"A549","Pearson.est","adrenergic receptor antagonist",0.40265,1.03,0.403,298,0.882,"atenolol...., RS.17053, dronedarone, pindolol, oxprenolol, prazosin",0.39469495385889,0.0545314148681803,FALSE +"A549","Pearson.est","AKT inhibitor",0.37852,0.967,0.476,227,0.799,"CCT128930, palomid.529, uprosertib",0.322393047279507,0.0974532206860086,FALSE +"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27572,-0.724,0.786,1141,0.872,"alectinib, AZD3463, lorlatinib, crizotinib",0.104577453960592,0.0594835150674328,FALSE +"A549","Pearson.est","androgen receptor antagonist",0.55479,1.41,0.144,648,0.495,"cyproterone.acetate, nilutamide, flutamide, enzalutamide, RU.58841, bicalutamide",0.84163750790475,0.305394801066431,FALSE +"A549","Pearson.est","antioxidant",-0.5227,-1.35,0.153,1188,0.317,"trolox, rutin, chlorogenic.acid, mesna",0.815308569182401,0.498940737782249,FALSE +"A549","Pearson.est","AP inhibitor",0.65772,1.67,0.0471,288,0.628,"embelin, tanshinone.i, LCL.161",1.3269790928711,0.202040356262804,FALSE +"A549","Pearson.est","ATPase inhibitor",-0.40148,-1.04,0.402,1288,0.674,"rabeprazole, digitoxigenin, oligomycin.a",0.39577394691553,0.17134010346468,FALSE +"A549","Pearson.est","Aurora kinase inhibitor",-0.6084,-1.56,0.0759,1217,0.417,"alisertib, CCT137690, danusertib, MLN.8054, TAK.901, hesperadin, AT.9283, PF.03814735, GSK1070916, MK.8745, MK.5108, AMG900",1.11975822410452,0.379863945026242,FALSE +"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.27847,0.702,0.808,1047,0.902,"dirithromycin, tilmicosin, josamycin, valnemulin, tedizolid, radezolid, azithromycin, azalomycin.b",0.0925886392254138,0.0447934624580583,FALSE +"A549","Pearson.est","bacterial DNA gyrase inhibitor",-0.53394,-1.41,0.122,1313,0.348,"lomefloxacin, novobiocin, finafloxacin",0.913640169325252,0.458420756053419,FALSE +"A549","Pearson.est","BCL inhibitor",0.5263,1.32,0.162,247,0.558,"ABT.737, navitoclax, obatoclax",0.790484985457369,0.253365801062421,FALSE +"A549","Pearson.est","Bcr.Abl kinase inhibitor",0.3087,0.805,0.689,177,0.846,"imatinib, flumatinib",0.161780778092374,0.0726296369609765,FALSE +"A549","Pearson.est","benzodiazepine receptor agonist",0.40284,1.05,0.377,293,0.913,"temazepam, CL.218872, indiplon, piperazine, gamma.aminobutyric.acid",0.423658649794207,0.039529222465701,FALSE +"A549","Pearson.est","bromodomain inhibitor",0.32751,0.841,0.63,502,0.806,"I.BET151, I.BET.762, JQ1...., bromosporine",0.200659450546418,0.0936649581949093,FALSE +"A549","Pearson.est","calcium channel blocker",0.35934,0.906,0.553,370,0.774,"SKF.96365, tetrandrine, mibefradil, efonidipine.monoethanolate, fendiline",0.257274868695302,0.111259039317107,FALSE +"A549","Pearson.est","CC chemokine receptor antagonist",-0.45726,-1.17,0.273,1317,0.525,"UNBS.5162, ZK811752",0.563837352959244,0.279840696594043,FALSE +"A549","Pearson.est","CDK inhibitor",0.34133,0.877,0.605,152,0.785,"CR8..R., BMS.387032, TG.02, indirubin, AT.7519, dinaciclib",0.218244625347531,0.105130343254747,FALSE +"A549","Pearson.est","CHK inhibitor",0.58127,1.49,0.0763,40,0.579,"PF.477736",1.11747546204512,0.237321436272564,FALSE +"A549","Pearson.est","cyclooxygenase inhibitor",-0.20648,-0.522,0.962,1037,0.973,"phenazone, amfenac, meloxicam, aspirin, metoxibutropate, suxibuzone, tepoxalin, curcumin, acetylsalicylsalicylic.acid",0.0168249279621871,0.0118871597316481,FALSE +"A549","Pearson.est","cytochrome P450 inhibitor",0.36402,0.931,0.534,609,0.77,"morin, itraconazole, metyrapone, cobicistat, clotrimazole",0.272458742971444,0.113509274827518,FALSE +"A549","Pearson.est","DNA alkylating agent",-0.32488,-0.824,0.655,1186,0.848,"TH.302, mitomycin.c, satraplatin, cyclophosphamide, carboplatin",0.183758700008217,0.0716041477432862,FALSE +"A549","Pearson.est","DNA inhibitor",-0.59924,-1.53,0.0998,1178,0.393,"tirapazamine, chlorambucil, oxaliplatin, sangivamycin, metronidazole, valrubicin, teroxirone, carboplatin",1.00086945871263,0.405607449624573,FALSE +"A549","Pearson.est","DNA methyltransferase inhibitor",0.2855,0.744,0.74,421,0.881,"fdcyd, SGI.1027, RG108, azacitidine",0.130768280269024,0.0550240915879521,FALSE +"A549","Pearson.est","DNA polymerase inhibitor",0.25392,0.654,0.876,324,0.905,"menadione, famciclovir, cidofovir",0.0574958938319193,0.0433514207947967,FALSE +"A549","Pearson.est","DNA synthesis inhibitor",-0.4077,-1.09,0.36,1022,0.624,"altretamine, artemisinin, anisomycin, azodicarbonamide, CB.10.277, mitomycin.c, cyclocytidine, artesunate, floxuridine",0.443697499232713,0.204815410317576,FALSE +"A549","Pearson.est","dopamine receptor antagonist",0.23811,0.609,0.913,175,0.93,"lurasidone, mesoridazine, nemonapride",0.039529222465701,0.0315170514460649,FALSE +"A549","Pearson.est","estrogen receptor agonist",-0.29428,-0.763,0.701,1121,0.88,"estradiol.cypionate, estrone, levonorgestrel",0.154281982033341,0.0555173278498314,FALSE +"A549","Pearson.est","estrogen receptor antagonist",0.2933,0.753,0.76,89,0.909,"tamoxifen",0.119186407719209,0.0414361167780325,FALSE +"A549","Pearson.est","FGFR inhibitor",0.55741,1.4,0.14,340,0.477,"orantinib, PD.173074, erdafitinib, lucitanib, lenvatinib",0.853871964321762,0.321481620959886,FALSE +"A549","Pearson.est","FLT3 inhibitor",0.19746,0.49,0.979,500,0.983,"TG.02, pacritinib, tandutinib, TG.101348, gilteritinib, sorafenib, sunitinib",0.00921730819686218,0.00744648216786438,FALSE +"A549","Pearson.est","glucocorticoid receptor agonist",-0.27503,-0.712,0.802,1113,0.858,"dexamethasone.acetate, beclomethasone.dipropionate, prednisolone, fluocinolone.acetonide, triamcinolone, ciclesonide, desonide, fluticasone.propionate",0.0958256317158365,0.0665127121512946,FALSE +"A549","Pearson.est","glutamate receptor antagonist",0.56527,1.45,0.108,492,0.549,"LY456236, CPP, kynurenic.acid, MTPG, diazooxonorleucine, JNJ.16259685, latrepirdine, ACDPP, felbamate, IEM1754",0.96657624451305,0.260427655549908,FALSE +"A549","Pearson.est","glycogen synthase kinase inhibitor",0.27913,0.707,0.802,310,0.915,"indirubin, GSK.3.inhibitor.IX",0.0958256317158365,0.0385789059335517,FALSE +"A549","Pearson.est","growth factor receptor inhibitor",-0.57284,-1.44,0.118,1179,0.382,"AZD3463, lestaurtinib, danusertib, PHA.848125",0.928117992693875,0.417936637088291,FALSE +"A549","Pearson.est","HCV inhibitor",0.63814,1.65,0.0423,489,0.421,"embelin, PSI.7976, narlaprevir, daclatasvir",1.37365963262496,0.375717904164332,FALSE +"A549","Pearson.est","HDAC inhibitor",0.29041,0.746,0.768,434,0.898,"pyroxamide, nexturastat.a, SB.939, vorinostat, R306465, belinostat, panobinostat, RG2833",0.114638779968488,0.0467236633326956,FALSE +"A549","Pearson.est","histamine receptor antagonist",0.54233,1.41,0.13,510,0.495,"chloropyramine, tecastemizole, ICI.162846, astemizole, cyproheptadine, tiotidine, epinastine, terfenadine, nizatidine, cimetidine, levocetirizine, BF2.649, famotidine",0.886056647693163,0.305394801066431,FALSE +"A549","Pearson.est","HMGCR inhibitor",-0.58618,-1.49,0.0776,1108,0.351,"fluvastatin, pitavastatin, simvastatin",1.11013827874181,0.454692883534176,FALSE +"A549","Pearson.est","HSP inhibitor",-0.24733,-0.646,0.884,1205,0.909,"ganetespib, PU.H71, NMS.E973, BIIB021",0.0535477349869269,0.0414361167780325,FALSE +"A549","Pearson.est","JAK inhibitor",0.33189,0.856,0.628,249,0.799,"TG.02, LY2784544, AZD1480, atiprimod, pacritinib",0.202040356262804,0.0974532206860086,FALSE +"A549","Pearson.est","KIT inhibitor",0.45635,1.18,0.269,500,0.733,"imatinib, cediranib, motesanib, pazopanib, tandutinib, lenvatinib, telatinib, sorafenib, vatalanib, sunitinib",0.570247719997592,0.134896025358872,FALSE +"A549","Pearson.est","MDM inhibitor",-0.65691,-1.68,0.039,1122,0.292,"nutlin.3, serdemetan, RITA, idasanutlin",1.4089353929735,0.534617148551582,FALSE +"A549","Pearson.est","MEK inhibitor",-0.54657,-1.4,0.139,1173,0.331,"MEK162, PD.198306, AS.703026, trametinib, AZD8330, PD.98059, PD.184352, PD.318088, PD.0325901, Ro.4987655, refametinib",0.856985199745905,0.480172006224281,FALSE +"A549","Pearson.est","MET inhibitor",-0.33029,-0.864,0.589,1331,0.852,"PF.04217903",0.229884705212898,0.0695604052332999,FALSE +"A549","Pearson.est","microtubule inhibitor",-0.36484,-0.958,0.471,1127,0.75,"cabazitaxel, D.64131, secnidazole, vinflunine, vinblastine",0.326979092871104,0.1249387366083,FALSE +"A549","Pearson.est","mTOR inhibitor",-0.58724,-1.52,0.0888,1068,0.352,"deforolimus, OSI.027, sirolimus, GDC.0980, PI.103, AZD2014, WYE.125132, voxtalisib, XL388, PF.04691502, NVP.BEZ235, LY303511, GSK2126458, PKI.179, MLN0128, torin.1, ku.0063794, PP242, SB.2343",1.0515870342214,0.453457336521869,FALSE +"A549","Pearson.est","NFkB pathway inhibitor",0.42986,1.1,0.337,145,0.836,"Ro.106.9920, parthenolide, tyloxapol, bortezomib",0.472370099128661,0.0777937225609836,FALSE +"A549","Pearson.est","opioid receptor agonist",0.36717,0.945,0.478,178,0.767,"ADL5859, salvinorin.a",0.320572103387881,0.115204636051019,FALSE +"A549","Pearson.est","p38 MAPK inhibitor",0.25811,0.668,0.86,404,0.907,"TAK.715, SB.242235, SB.239063",0.0655015487564323,0.0423927129399047,FALSE +"A549","Pearson.est","PARP inhibitor",-0.33705,-0.859,0.617,1006,0.824,"AG.14361, AZD2461, niraparib, talazoparib, olaparib",0.209714835966758,0.0840727883028842,FALSE +"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.39537,1.02,0.4,532,0.837,"orantinib, imatinib, motesanib, pazopanib, tandutinib, linifanib, lenvatinib, telatinib, sorafenib, vatalanib, trapidil, sunitinib, CP.673451",0.397940008672038,0.07727454200674,FALSE +"A549","Pearson.est","phosphatase inhibitor",-0.28521,-0.735,0.755,1367,0.888,"mycophenolic.acid, bis.maltolato.oxovanadium.IV.",0.122053048370812,0.051587034221399,FALSE +"A549","Pearson.est","phosphodiesterase inhibitor",0.40097,1.03,0.415,205,0.882,"cilostamide, avanafil, anagrelide",0.381951903287907,0.0545314148681803,FALSE +"A549","Pearson.est","PI3K inhibitor",-0.5217,-1.38,0.122,1170,0.33,"CH5132799, GDC.0980, PI.103, voxtalisib, PF.04691502, NVP.BEZ235, LY303511, buparlisib, ZSTK.474, GSK2126458, PKI.179, GDC.0941, YM.201636, SB.2343",0.913640169325252,0.481486060122112,FALSE +"A549","Pearson.est","PLK inhibitor",-0.78071,-2.02,0.0042,1125,0.0791,"BI.2536, volasertib, rigosertib, NMS.1286937, GSK461364, GW.843682X, HMN.214",2.3767507096021,1.10182351650232,TRUE +"A549","Pearson.est","potassium channel blocker",0.3741,0.961,0.467,292,0.762,"dofetilide, oleoylethanolamide",0.330683119433888,0.1180450286604,FALSE +"A549","Pearson.est","PPAR receptor agonist",0.50919,1.34,0.152,292,0.554,"S26948, GW.501516, oleoylethanolamide",0.818156412055227,0.25649023527157,FALSE +"A549","Pearson.est","progesterone receptor agonist",-0.29156,-0.776,0.74,1104,0.894,"nomegestrol.acetate, levonorgestrel, norethindrone, tanaproget",0.130768280269024,0.0486624812040823,FALSE +"A549","Pearson.est","proteasome inhibitor",0.40861,1.02,0.419,437,0.837,"carfilzomib, bortezomib, ixazomib.citrate, oprozomib",0.377785977033705,0.07727454200674,FALSE +"A549","Pearson.est","protein synthesis inhibitor",-0.37086,-0.972,0.443,1053,0.763,"anguidine, thiostrepton, methacycline, harringtonine, chloramphenicol.palmitate, mercaptopurine, cycloheximide",0.35359627377693,0.11747546204512,FALSE +"A549","Pearson.est","protein tyrosine kinase inhibitor",0.55725,1.45,0.108,261,0.549,"CP.724714, BMS.599626, AV.412",0.96657624451305,0.260427655549908,FALSE +"A549","Pearson.est","RAF inhibitor",0.49044,1.26,0.203,221,0.637,"dabrafenib, GDC.0879, CEP.32496, PLX.4720",0.692503962086787,0.19586056766465,FALSE +"A549","Pearson.est","RET tyrosine kinase inhibitor",0.34361,0.884,0.575,500,0.793,"vandetanib, apatinib, sorafenib, sunitinib",0.24033215531037,0.100726812682396,FALSE +"A549","Pearson.est","retinoid receptor agonist",0.39706,1,0.421,266,0.817,"adarotene, tamibarotene, fenretinide",0.375717904164332,0.0877779434675845,FALSE +"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.54322,-1.42,0.126,1028,0.369,"triapine, gemcitabine, fludarabine.phosphate, clofarabine, fludarabine, cladribine, hydroxyurea",0.899629454882437,0.43297363384094,FALSE +"A549","Pearson.est","serotonin receptor agonist",0.63096,1.6,0.0585,1,0.468,"aripiprazole",1.23284413391782,0.329754146925876,FALSE +"A549","Pearson.est","serotonin receptor antagonist",0.56603,1.44,0.113,100,0.52,"aripiprazole, lurasidone, lerisetron",0.94692155651658,0.283996656365201,FALSE +"A549","Pearson.est","sodium channel blocker",0.27157,0.687,0.843,103,0.903,"triamterene, lappaconite",0.0741724253752577,0.0443122496864942,FALSE +"A549","Pearson.est","src inhibitor",0.4546,1.16,0.294,184,0.739,"ZM.306416, PP.1, saracatinib",0.531652669587843,0.131355561605174,FALSE +"A549","Pearson.est","sterol demethylase inhibitor",-0.71174,-1.78,0.0235,1380,0.327,"chlormidazole, lanoconazole",1.62893213772826,0.485452247339714,FALSE +"A549","Pearson.est","TGF beta receptor inhibitor",0.77692,1.97,0.00194,234,0.2,"SB.431542, LY2109761, D.4476, repsox, SB.525334",2.71219827006977,0.698970004336019,TRUE +"A549","Pearson.est","thymidylate synthase inhibitor",0.38422,0.974,0.48,149,0.812,"doxifluridine, capecitabine",0.318758762624413,0.0904439707588247,FALSE +"A549","Pearson.est","topoisomerase inhibitor",-0.63925,-1.69,0.0323,1098,0.363,"topotecan, camptothecin, teniposide, genz.644282, nemorubicin, SN.38, rubitecan, etoposide, amonafide, valrubicin, idarubicin, doxorubicin, voreloxin, epirubicin, TAS.103, mitoxantrone, amsacrine",1.4907974776689,0.440093374963888,FALSE +"A549","Pearson.est","tubulin polymerization inhibitor",-0.5197,-1.37,0.127,1189,0.317,"KX2.391, fenbendazole, oxibendazole, epothilone.b, taltobulin, vinblastine, mebendazole, verubulin, BNC105",0.896196279044043,0.498940737782249,FALSE +"A549","Pearson.est","tyrosine kinase inhibitor",0.3591,0.915,0.526,323,0.779,"CP.724714, hypericin, BMS.599626, vandetanib, tivantinib, AV.412, apatinib",0.279014255846261,0.108462542327436,FALSE +"A549","Pearson.est","VEGFR inhibitor",0.46172,1.19,0.24,500,0.751,"orantinib, golvatinib, ZM.306416, PD.173074, AEE788, cediranib, motesanib, BMS.690514, vandetanib, pazopanib, lucitanib, linifanib, XL.647, lenvatinib, TG.100572, semaxanib, telatinib, sorafenib, vatalanib, MK.2461, tivozanib, sunitinib",0.619788758288394,0.124360062995832,FALSE +"A549","Pearson.est","vitamin D receptor agonist",0.3768,0.976,0.448,297,0.836,"paricalcitol, alfacalcidol, tacalcitol",0.348721986001856,0.0777937225609836,FALSE +"HCC15","Pearson.est","EGFR inhibitor",-0.38652,-1.06,0.373,1132,1,"salvianolic.acid.B, WZ.4002, pelitinib, XL.647, GW.583340, tyrphostin.AG.1478, BIBU.1361, PD.153035, gefitinib, BIBX.1382, icotinib, OSI.420, CNX.2006, erlotinib, rociletinib, vandetanib, WZ8040, PD.168393, CGP.52411",0.428291168191312,0,FALSE +"HCC15","Pearson.est","Abl kinase inhibitor",-0.23329,-0.623,0.879,335,0.993,"flumatinib, bafetinib, nilotinib, imatinib, tozasertib, metatinib, KW.2449, GZD824, ZM.306416, bosutinib, ponatinib, dasatinib",0.0560111249262281,0.00305075150461883,FALSE +"HCC15","Pearson.est","acetylcholine receptor agonist",0.6281,1.57,0.062,149,0.822,"xanomeline, oxiracetam, tremorine",1.20760831050175,0.0851281824599496,FALSE +"HCC15","Pearson.est","acetylcholine receptor antagonist",0.47883,1.21,0.257,753,0.649,"hyoscyamine, dicycloverine, darifenacin, iododexetimide, diphemanil",0.590066876668705,0.187755303199631,FALSE +"HCC15","Pearson.est","adenosine receptor antagonist",0.25799,0.633,0.896,456,0.911,"MRS.1220, PSB.1115, sulmazole",0.0476919903378748,0.0404816230270017,FALSE +"HCC15","Pearson.est","adrenergic receptor agonist",0.26164,0.648,0.87,359,0.915,"ritodrine, lidamidine, clenbuterol, isoxsuprine",0.0604807473813815,0.0385789059335517,FALSE +"HCC15","Pearson.est","adrenergic receptor antagonist",0.21637,0.541,0.958,308,0.961,"atipamezole, atenolol......, idazoxan, propranolol, naftidrofuryl",0.0186344909214556,0.0172766123314547,FALSE +"HCC15","Pearson.est","AKT inhibitor",-0.30982,-0.857,0.614,1166,1,"GSK2110183, CCT128930, AT7867",0.211831628858832,0,FALSE +"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.35289,-0.986,0.44,1228,1,"GW.788388, alectinib, AP26113, lorlatinib",0.356547323513813,0,FALSE +"HCC15","Pearson.est","androgen receptor antagonist",0.55579,1.38,0.143,568,0.714,"cyproterone.acetate, nilutamide, flutamide, bicalutamide, enzalutamide",0.844663962534938,0.146301788223826,FALSE +"HCC15","Pearson.est","antioxidant",-0.50475,-1.35,0.171,1239,0.824,"benfotiamine, rutin, mesna",0.767003889607846,0.0840727883028842,FALSE +"HCC15","Pearson.est","AP inhibitor",-0.38474,-1.04,0.399,1428,1,"embelin",0.399027104313252,0,FALSE +"HCC15","Pearson.est","ATPase inhibitor",0.51328,1.29,0.176,281,0.771,"k.strophanthidin, evodiamine, digoxin, NMS.873, digitoxin",0.75448733218585,0.112945621949043,FALSE +"HCC15","Pearson.est","Aurora kinase inhibitor",-0.30022,-0.832,0.657,1024,0.962,"alisertib, MK.8745, PF.03814735, TAK.901, AT.9283, barasertib.HQPA, CCT129202, GSK1070916, hesperadin, MLN.8054, CYC116",0.182434630440219,0.0168249279621871,FALSE +"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.35021,0.872,0.624,558,0.874,"josamycin, azithromycin, dirithromycin, tedizolid, tilmicosin",0.204815410317576,0.058488567365597,FALSE +"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.43702,1.08,0.358,330,0.679,"norfloxacin, sarafloxacin, trovafloxacin, sparfloxacin",0.446116973356126,0.168130225719498,FALSE +"HCC15","Pearson.est","BCL inhibitor",0.50347,1.26,0.213,620,0.74,"TW.37, oridonin, HA14.1, venetoclax, gossypol, ABT.737",0.671620396561262,0.130768280269024,FALSE +"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",-0.23296,-0.635,0.901,335,1,"flumatinib, bafetinib, nilotinib, imatinib, tozasertib, metatinib, GZD824, bosutinib, ponatinib, dasatinib",0.045275209020937,0,FALSE +"HCC15","Pearson.est","benzodiazepine receptor agonist",0.46792,1.15,0.293,252,0.713,"ZK.93423, temazepam, indiplon, bentazepam",0.533132379645891,0.146910470148134,FALSE +"HCC15","Pearson.est","bromodomain inhibitor",0.59131,1.46,0.0768,543,0.551,"PFI.1, JQ1...., bromosporine, I.BET151",1.11463877996849,0.258848401148215,FALSE +"HCC15","Pearson.est","calcium channel blocker",0.478,1.18,0.26,449,0.679,"fendiline, carboxyamidotriazole, tetrandrine, pranidipine, efonidipine.monoethanolate, SKF.96365",0.585026652029182,0.168130225719498,FALSE +"HCC15","Pearson.est","CC chemokine receptor antagonist",0.29485,0.733,0.797,596,0.894,"UNBS.5162, SB.225002, ZK811752, MK.0812, PF.04136309",0.0985416786038876,0.0486624812040823,FALSE +"HCC15","Pearson.est","CDK inhibitor",-0.17742,-0.483,0.992,253,0.985,"BMS.387032, CR8..R., PHA.848125, PHA.793887, indisulam, kenpaullone, arcyriaflavin.a, JNJ.7706621, TG.02, AZD5438, dinaciclib, P276.00, AT.7519, abemaciclib, alvocidib, BMS.265246, R547, indirubin, aminopurvalanol.a, NU6027, palbociclib, ribociclib",0.00348832784582135,0.00656376950238827,FALSE +"HCC15","Pearson.est","CHK inhibitor",0.49536,1.23,0.232,505,0.676,"PF.477736, LY2606368, CHIR.124, SB.218078, LY2603618",0.6345120151091,0.170053304058364,FALSE +"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.35461,-0.962,0.485,1120,1,"curcumin, meloxicam, acetylsalicylsalicylic.acid, indoprofen, tryptanthrin, amfenac, pterostilbene",0.314258261397736,0,FALSE +"HCC15","Pearson.est","cytochrome P450 inhibitor",0.43791,1.09,0.372,735,0.712,"eplerenone, morin, itraconazole, PF.4981517, metyrapone",0.429457060118102,0.147520006363144,FALSE +"HCC15","Pearson.est","DNA alkylating agent",-0.29167,-0.792,0.681,1234,0.918,"carboplatin, streptozotocin, cyclophosphamide, TH.302, dianhydrogalactitol",0.166852888087215,0.0371573187987575,FALSE +"HCC15","Pearson.est","DNA inhibitor",0.33575,0.826,0.671,417,0.882,"mechlorethamine, teroxirone, valrubicin, metronidazole, melphalan, primaquine, sangivamycin, bendamustine",0.173277479831008,0.0545314148681803,FALSE +"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.5169,1.28,0.201,406,0.739,"SGI.1027, decitabine, disulfiram",0.696803942579511,0.131355561605174,FALSE +"HCC15","Pearson.est","DNA polymerase inhibitor",0.42252,1.06,0.389,353,0.646,"trifluridine, idoxuridine, menadione",0.410050398674292,0.189767482004916,FALSE +"HCC15","Pearson.est","DNA synthesis inhibitor",0.32144,0.804,0.683,378,0.852,"azodicarbonamide, artesunate, floxuridine, mitomycin.c",0.165579296318467,0.0695604052332999,FALSE +"HCC15","Pearson.est","dopamine receptor antagonist",-0.44029,-1.18,0.256,1200,0.844,"nemonapride, amisulpride, clebopride, remoxipride, acetophenazine, oxiperomide",0.59176003468815,0.073657553374345,FALSE +"HCC15","Pearson.est","estrogen receptor agonist",-0.31142,-0.864,0.612,1419,1,"PPT",0.213248577854439,0,FALSE +"HCC15","Pearson.est","estrogen receptor antagonist",-0.31137,-0.879,0.584,449,1,"danazol, clomifene, toremifene, tamoxifen, raloxifene, fulvestrant",0.233587152887601,0,FALSE +"HCC15","Pearson.est","FGFR inhibitor",0.59685,1.49,0.0876,229,0.947,"regorafenib, dovitinib, erdafitinib, nintedanib",1.05749589383192,0.0236500209967266,FALSE +"HCC15","Pearson.est","FLT3 inhibitor",0.3372,0.822,0.663,377,0.844,"dovitinib, sorafenib, GTP.14564, quizartinib, tandutinib",0.178486471595227,0.073657553374345,FALSE +"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.18591,-0.504,0.986,1329,1,"fluticasone.propionate, fluorometholone, prednisolone.acetate",0.0061230850587888,0,FALSE +"HCC15","Pearson.est","glutamate receptor antagonist",-0.27701,-0.745,0.746,1309,0.965,"CPP, latrepirdine, SIB.1757",0.127261172527331,0.0154726866562074,FALSE +"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.29882,-0.825,0.617,430,0.932,"AZD2858, tideglusib, kenpaullone, CHIR.99021, GSK.3.inhibitor.IX, TWS.119, indirubin, CHIR.98014, LY2090314",0.209714835966758,0.0305840876460186,FALSE +"HCC15","Pearson.est","growth factor receptor inhibitor",0.33223,0.825,0.679,321,0.861,"GSK1838705A, PHA.848125",0.168130225719498,0.0649968485463452,FALSE +"HCC15","Pearson.est","HCV inhibitor",-0.46572,-1.25,0.194,1379,0.862,"Ro.9187, embelin",0.712198270069774,0.0644927341752872,FALSE +"HCC15","Pearson.est","HDAC inhibitor",-0.31444,-0.867,0.593,1250,1,"romidepsin, entinostat, tacedinaline, RG2833, mocetinostat, JNJ.26481585",0.226945306635737,0,FALSE +"HCC15","Pearson.est","histamine receptor antagonist",-0.30731,-0.843,0.632,1354,0.983,"levocetirizine, tiotidine, pheniramine",0.199282921717615,0.00744648216786438,FALSE +"HCC15","Pearson.est","HMGCR inhibitor",-0.46536,-1.25,0.202,1401,0.862,"simvastatin",0.694648630553376,0.0644927341752872,FALSE +"HCC15","Pearson.est","HSP inhibitor",0.53557,1.32,0.148,539,0.82,"SNX.2112, KW.2478, NMS.E973, SNX.5422, ganetespib, BIIB021, NVP.AUY922, guanidine, PU.H71, XL888",0.829738284605043,0.0861861476162833,FALSE +"HCC15","Pearson.est","JAK inhibitor",0.2889,0.712,0.796,211,0.9,"baricitinib, CEP.33779, AZD1480",0.0990869322623309,0.0457574905606751,FALSE +"HCC15","Pearson.est","KIT inhibitor",0.39173,0.971,0.486,236,0.762,"regorafenib, OSI.930, sorafenib, pazopanib, masitinib",0.313363730737707,0.1180450286604,FALSE +"HCC15","Pearson.est","MDM inhibitor",-0.86092,-2.33,0,1352,0.00694,"CGM097, idasanutlin, AMG.232, RITA",Inf,2.15864052954515,TRUE +"HCC15","Pearson.est","MEK inhibitor",-0.81982,-2.22,0,1257,0.0202,"BIX.02188, PD.98059, U.0126, PD.198306, PD.0325901, MEK162, PD.184352, PD.318088, trametinib, cobimetinib, TAK.733, AS.703026, AZD8330, refametinib, selumetinib, Ro.4987655",Inf,1.69464863055338,TRUE +"HCC15","Pearson.est","MET inhibitor",-0.54167,-1.44,0.12,1208,0.904,"INC.280, PHA.665752, PF.04217903",0.920818753952375,0.0438315695246367,FALSE +"HCC15","Pearson.est","microtubule inhibitor",0.60121,1.47,0.0683,442,0.6,"colchicine, vinblastine, D.64131, vinflunine, cabazitaxel, podophyllotoxin, triclabendazole",1.16557929631847,0.221848749616356,FALSE +"HCC15","Pearson.est","mTOR inhibitor",-0.44858,-1.24,0.196,1020,0.788,"GSK2126458, torin.1, MLN0128, OSI.027, temsirolimus, AZD8055, PF.04691502, LY3023414, SB.2343, GDC.0980, NVP.BEZ235, WYE.354, XL388, sirolimus, PF.05212384",0.707743928643524,0.103473782510445,FALSE +"HCC15","Pearson.est","NFkB pathway inhibitor",-0.30491,-0.873,0.595,1263,1,"Ro.106.9920, parthenolide, BAY.11.7082, parthenolide....",0.22548303427145,0,FALSE +"HCC15","Pearson.est","opioid receptor agonist",0.37916,0.952,0.505,282,0.774,"cebranopadol, spiradoline, trimebutine",0.296708621881339,0.111259039317107,FALSE +"HCC15","Pearson.est","p38 MAPK inhibitor",-0.26024,-0.689,0.842,375,0.98,"talmapimod, SB.242235, SB.239063, TAK.715, VX.702, CMPD.1, skepinone.l",0.0746879085003505,0.00877392430750515,FALSE +"HCC15","Pearson.est","PARP inhibitor",-0.35055,-0.956,0.483,1246,1,"E7449, endo.IWR.1",0.316052869248488,0,FALSE +"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.3086,0.761,0.745,307,0.875,"regorafenib, dovitinib, sorafenib, pazopanib, nintedanib, masitinib, crenolanib",0.127843727251707,0.0579919469776868,FALSE +"HCC15","Pearson.est","phosphatase inhibitor",0.6019,1.48,0.0824,435,0.799,"AS.1949490, CID.5458317, GSK2830371, sodium.stibogluconate, menadione, mycophenolic.acid",1.08407278830288,0.0974532206860086,FALSE +"HCC15","Pearson.est","phosphodiesterase inhibitor",0.43394,1.07,0.365,497,0.65,"enoximone, avanafil, EMD.53998, cilostamide",0.437707135543525,0.187086643357144,FALSE +"HCC15","Pearson.est","PI3K inhibitor",-0.2778,-0.741,0.763,1000,0.935,"CUDC.907, GSK2126458, PI3K.IN.2, ZSTK.474, alpelisib, PIK.75, pilaralisib, PF.04691502, CH5132799, GDC.0941, LY3023414, SB.2343, GDC.0980, NVP.BEZ235, PF.05212384",0.11747546204512,0.0291883891274822,FALSE +"HCC15","Pearson.est","PLK inhibitor",0.76613,1.89,0,344,0.215,"volasertib, NMS.1286937, GW.843682X, BI.2536, HMN.214, rigosertib, GSK461364",Inf,0.667561540084395,TRUE +"HCC15","Pearson.est","potassium channel blocker",0.45215,1.12,0.338,158,0.712,"ML133, dofetilide",0.471083299722345,0.147520006363144,FALSE +"HCC15","Pearson.est","PPAR receptor agonist",-0.50402,-1.38,0.135,1138,0.894,"GW.501516, clofibrate, fenofibrate, pterostilbene",0.869666231504994,0.0486624812040823,FALSE +"HCC15","Pearson.est","progesterone receptor agonist",-0.28978,-0.794,0.688,417,0.952,"norethindrone, danazol, norethindrone.acetate, melengestrol.acetate, nomegestrol.acetate, tanaproget, norgestrel, dienogest, levonorgestrel",0.162411561764489,0.0213630516155257,FALSE +"HCC15","Pearson.est","proteasome inhibitor",0.36987,0.923,0.534,58,0.803,"MG.132",0.272458742971444,0.095284454721319,FALSE +"HCC15","Pearson.est","protein synthesis inhibitor",0.50191,1.25,0.212,617,0.715,"puromycin, clofoctol, thiostrepton, homoharringtonine, harringtonine, bruceantin, methacycline, anguidine, cycloheximide, chloramphenicol.palmitate, mercaptopurine, emetine, tedizolid.phosphate",0.673664139071249,0.145693958198919,FALSE +"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.49997,1.22,0.242,218,0.662,"tyrphostin.A9, PP.121, mubritinib",0.616184634019569,0.1791420105603,FALSE +"HCC15","Pearson.est","RAF inhibitor",0.52448,1.3,0.192,540,0.807,"SB.590885, regorafenib, RAF265, sorafenib, TAK.632, PLX.4720, GDC.0879, dabrafenib, vemurafenib",0.71669877129645,0.0931264652779296,FALSE +"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.43876,1.08,0.377,142,0.679,"regorafenib, sorafenib",0.423658649794207,0.168130225719498,FALSE +"HCC15","Pearson.est","retinoid receptor agonist",0.40454,1.02,0.439,9,0.695,"adarotene",0.357535479757879,0.158015195409886,FALSE +"HCC15","Pearson.est","ribonucleotide reductase inhibitor",0.33036,0.828,0.674,612,0.902,"fludarabine.phosphate, triapine, hydroxyurea, LY2334737, gemcitabine, cladribine, cytarabine",0.17134010346468,0.0447934624580583,FALSE +"HCC15","Pearson.est","serotonin receptor agonist",0.44725,1.11,0.344,124,0.702,"pardoprunox, zolmitriptan",0.46344155742847,0.153662887870195,FALSE +"HCC15","Pearson.est","serotonin receptor antagonist",0.45891,1.14,0.301,346,0.702,"SB.200646, lerisetron, sertindole, pirenperone, tropisetron, lurasidone",0.521433504406157,0.153662887870195,FALSE +"HCC15","Pearson.est","sodium channel blocker",-0.1827,-0.493,0.968,1194,1,"mexiletine, lappaconite, benzocaine, butamben",0.0141246426916063,0,FALSE +"HCC15","Pearson.est","src inhibitor",0.2849,0.708,0.803,279,0.886,"KX2.391, masitinib, TG.100572",0.095284454721319,0.0525662781129492,FALSE +"HCC15","Pearson.est","sterol demethylase inhibitor",0.31262,0.764,0.766,48,0.891,"chlormidazole",0.115771230367396,0.0501222959631252,FALSE +"HCC15","Pearson.est","TGF beta receptor inhibitor",0.28295,0.694,0.825,167,0.884,"LY2109761",0.0835460514500749,0.0535477349869269,FALSE +"HCC15","Pearson.est","thymidylate synthase inhibitor",0.5842,1.47,0.0927,227,0.6,"trifluridine, raltitrexed, ftorafur",1.0329202658555,0.221848749616356,FALSE +"HCC15","Pearson.est","topoisomerase inhibitor",0.49744,1.23,0.217,216,0.676,"dexrazoxane, exatecan.mesylate, epirubicin, daunorubicin, topotecan, etoposide.phosphate, mitoxantrone, doxorubicin, valrubicin, SN.38",0.66354026615147,0.170053304058364,FALSE +"HCC15","Pearson.est","tubulin polymerization inhibitor",0.65572,1.6,0.0424,437,1,"vinorelbine, vindesine, vincristine, taltobulin, vinblastine, parbendazole, BNC105, dolastatin.10, paclitaxel, verubulin, fenbendazole, CYT.997, docetaxel, oxibendazole, KX2.391, flubendazole, albendazole, nocodazole, ABT.751, podophyllotoxin, fosbretabulin, indibulin, epothilone.b",1.37263414340727,0,FALSE +"HCC15","Pearson.est","tyrosine kinase inhibitor",0.43986,1.07,0.374,218,0.65,"tivantinib, tyrphostin.A9, regorafenib, hypericin, sorafenib, PP.121, GTP.14564, mubritinib",0.42712839779952,0.187086643357144,FALSE +"HCC15","Pearson.est","VEGFR inhibitor",0.35742,0.869,0.629,279,0.855,"regorafenib, RAF265, dovitinib, OSI.930, sorafenib, pazopanib, tivozanib, nintedanib, TG.100572",0.201349354554731,0.0680338852718274,FALSE +"HCC15","Pearson.est","vitamin D receptor agonist",-0.69106,-1.88,0.0108,1134,0.193,"calcitriol, tacalcitol, maxacalcitol, paricalcitol, ercalcitriol, doxercalciferol",1.96657624451305,0.714442690992226,TRUE +"HCC44","Pearson.est","EGFR inhibitor",0.58846,1.67,0.0425,394,0.371,"AEE788, AZD8931, tucatinib, GW.583340, CP.724714, dacomitinib, CNX.2006, canertinib, BIBX.1382, poziotinib, BMS.690514, neratinib, gefitinib, ARRY.334543, afatinib, WZ8040, pelitinib, OSI.420, osimertinib, PD.153035, salvianolic.acid.B, vandetanib, XL.647, CUDC.101, icotinib, WZ.4002, PD.168393",1.37161106994969,0.430626090384954,FALSE +"HCC44","Pearson.est","Abl kinase inhibitor",-0.57634,-1.46,0.0935,1061,0.367,"dasatinib, ponatinib, bafetinib, tozasertib, GZD824, KW.2449",1.02918838912748,0.435333935747911,FALSE +"HCC44","Pearson.est","acetylcholine receptor agonist",-0.4165,-1.03,0.402,1215,0.788,"tremorine, nicotine",0.39577394691553,0.103473782510445,FALSE +"HCC44","Pearson.est","acetylcholine receptor antagonist",0.85629,2.34,0,158,0.00236,"dicycloverine, diphemanil, darifenacin, iododexetimide",Inf,2.62708799702989,TRUE +"HCC44","Pearson.est","adenosine receptor antagonist",0.57518,1.61,0.0676,103,0.37,"CGS.15943, istradefylline, MRS.1220",1.17005330405836,0.431798275933005,FALSE +"HCC44","Pearson.est","adrenergic receptor agonist",-0.32066,-0.79,0.733,997,1,"clenbuterol, terbutaline, midodrine, metaraminol, norepinephrine, buphenine, epinephrine",0.134896025358872,0,FALSE +"HCC44","Pearson.est","adrenergic receptor antagonist",0.40547,1.11,0.307,100,0.749,"RS.17053, prazosin, atenolol......, atenolol....",0.512861624522813,0.125518182300534,FALSE +"HCC44","Pearson.est","AKT inhibitor",-0.28401,-0.706,0.818,919,0.908,"uprosertib, ONC201, triciribine, GDC.0068",0.087246696328677,0.0419141514789149,FALSE +"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.25075,-0.615,0.899,1291,0.964,"alectinib, crizotinib",0.0462403082667712,0.0159229660971692,FALSE +"HCC44","Pearson.est","androgen receptor antagonist",-0.35987,-0.893,0.596,1145,0.93,"bicalutamide",0.224753740259764,0.0315170514460649,FALSE +"HCC44","Pearson.est","antioxidant",-0.73284,-1.83,0.0087,1284,0.115,"chlorogenic.acid, mesna",2.06048074738138,0.939302159646388,TRUE +"HCC44","Pearson.est","AP inhibitor",0.37141,1.05,0.362,200,0.767,"tanshinone.i, embelin",0.441291429466834,0.115204636051019,FALSE +"HCC44","Pearson.est","ATPase inhibitor",0.36086,1.03,0.397,81,0.714,"k.strophanthidin, blebbistatin....",0.401209493236885,0.146301788223826,FALSE +"HCC44","Pearson.est","Aurora kinase inhibitor",-0.72864,-1.81,0.00709,1243,0.103,"danusertib, AT.9283, barasertib, GSK1070916, MLN.8054, MK.8745, CCT137690, SNS.314, alisertib, tozasertib, AMG900, MK.5108, KW.2449, hesperadin, PF.03814735",2.14935376481693,0.987162775294828,TRUE +"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.28045,-0.71,0.811,1047,0.924,"josamycin, tedizolid",0.090979145788844,0.0343280287798933,FALSE +"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.70873,-1.78,0.00902,1364,0.107,"lomefloxacin, finafloxacin, novobiocin",2.04479346245806,0.97061622231479,TRUE +"HCC44","Pearson.est","BCL inhibitor",0.19514,0.546,0.961,1167,1,"ABT.737, obatoclax, gossypol, navitoclax, HA14.1, venetoclax, oridonin, TW.37",0.0172766123314547,0,FALSE +"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.64527,-1.6,0.032,1061,0.252,"dasatinib, ponatinib, bafetinib, tozasertib, GZD824",1.49485002168009,0.598599459218456,FALSE +"HCC44","Pearson.est","benzodiazepine receptor agonist",0.4494,1.26,0.202,66,0.693,"indiplon, temazepam, nefiracetam",0.694648630553376,0.159266765388193,FALSE +"HCC44","Pearson.est","bromodomain inhibitor",-0.529,-1.32,0.168,991,0.463,"JQ1...., PFI.1, OTX015, I.BET.762",0.774690718274137,0.334419008982047,FALSE +"HCC44","Pearson.est","calcium channel blocker",0.5276,1.38,0.137,98,0.532,"tetrandrine, fendiline, efonidipine.monoethanolate",0.863279432843593,0.274088367704952,FALSE +"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.55633,-1.39,0.12,988,0.387,"SB.225002, RS.504393, ZK811752, navarixin, UNBS.5162",0.920818753952375,0.412289034981089,FALSE +"HCC44","Pearson.est","CDK inhibitor",-0.37449,-0.928,0.54,1027,0.946,"aminopurvalanol.a, P276.00, kenpaullone, palbociclib, PHA.848125, alvocidib, BMS.265246, PHA.793887, abemaciclib, AZD5438, R547",0.267606240177031,0.0241088635982073,FALSE +"HCC44","Pearson.est","CHK inhibitor",0.32299,0.876,0.564,57,0.85,"PF.477736",0.248720896016658,0.0705810742857073,FALSE +"HCC44","Pearson.est","cyclooxygenase inhibitor",-0.29931,-0.742,0.793,1046,0.966,"ketoprofen, indoprofen, piroxicam, meloxicam, acetylsalicylsalicylic.acid, sulfasalazine, curcumin, ramifenazone, aspirin, suxibuzone",0.100726812682396,0.0150228735845067,FALSE +"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.34646,-0.872,0.632,1124,0.944,"eplerenone, PF.4981517, cobicistat, clotrimazole",0.199282921717615,0.025028005701931,FALSE +"HCC44","Pearson.est","DNA alkylating agent",-0.45734,-1.13,0.323,981,0.751,"estramustine, dianhydrogalactitol, melphalan, mitomycin.c, carmustine, cyclophosphamide, TH.302, carboplatin",0.490797477668897,0.124360062995832,FALSE +"HCC44","Pearson.est","DNA inhibitor",-0.54845,-1.36,0.138,883,0.415,"mechlorethamine, metronidazole, nimorazole, sangivamycin, melphalan, carmustine, tirapazamine, teroxirone, chlorambucil, valrubicin, carboplatin",0.860120913598763,0.381951903287907,FALSE +"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.49629,-1.23,0.225,1221,0.566,"fdcyd, decitabine",0.647817481888638,0.247183568811729,FALSE +"HCC44","Pearson.est","DNA polymerase inhibitor",-0.2916,-0.718,0.793,1290,0.955,"foscarnet, trifluridine",0.100726812682396,0.0199966284162537,FALSE +"HCC44","Pearson.est","DNA synthesis inhibitor",-0.43722,-1.07,0.388,1300,0.787,"CB.10.277, cyclocytidine, floxuridine",0.411168274405793,0.104025267640935,FALSE +"HCC44","Pearson.est","dopamine receptor antagonist",0.21323,0.593,0.913,217,1,"remoxipride, lurasidone, mesoridazine, nemonapride",0.039529222465701,0,FALSE +"HCC44","Pearson.est","estrogen receptor agonist",-0.44416,-1.08,0.373,910,0.796,"ethinyl.estradiol, PPT, estrone, estradiol, estradiol.cypionate",0.428291168191312,0.0990869322623309,FALSE +"HCC44","Pearson.est","estrogen receptor antagonist",0.54194,1.54,0.0772,41,0.397,"tamoxifen",1.11238269966426,0.401209493236885,FALSE +"HCC44","Pearson.est","FGFR inhibitor",0.55788,1.53,0.0938,83,0.353,"orantinib, PD.173074, lenvatinib",1.02779716162094,0.452225294612177,FALSE +"HCC44","Pearson.est","FLT3 inhibitor",-0.32239,-0.793,0.714,1081,1,"ponatinib, ENMD.2076, tandutinib, gilteritinib, tozasertib, KW.2449",0.146301788223826,0,FALSE +"HCC44","Pearson.est","glucocorticoid receptor agonist",0.39018,1.07,0.359,293,0.778,"triamcinolone.acetonide, hydrocortisone, deflazacort, dexamethasone.acetate, piretanide, prednisolone.hemisuccinate, halcinonide, flumethasone.pivalate, betamethasone, rimexolone",0.444905551421681,0.109020403010311,FALSE +"HCC44","Pearson.est","glutamate receptor antagonist",0.44047,1.22,0.221,314,0.709,"CGP.37849, MTPG, LY456236, CPP, kynurenic.acid, latrepirdine",0.655607726314889,0.149353764816933,FALSE +"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.40932,-1.03,0.437,995,0.788,"CHIR.99021, kenpaullone, LY2090314, tideglusib",0.359518563029578,0.103473782510445,FALSE +"HCC44","Pearson.est","growth factor receptor inhibitor",-0.5787,-1.44,0.0979,1243,0.348,"danusertib, PHA.848125, GSK1838705A",1.00921730819686,0.458420756053419,FALSE +"HCC44","Pearson.est","HCV inhibitor",0.41015,1.14,0.274,200,0.747,"PSI.7976, embelin",0.562249437179612,0.126679398184601,FALSE +"HCC44","Pearson.est","HDAC inhibitor",-0.21875,-0.541,0.952,1138,0.957,"R306465, dacinostat, entinostat, NSC.3852, trichostatin.a, givinostat",0.0213630516155257,0.0190880622231565,FALSE +"HCC44","Pearson.est","histamine receptor antagonist",0.29145,0.835,0.624,260,0.891,"tecastemizole, ebastine, epinastine, famotidine, chloropyramine, astemizole",0.204815410317576,0.0501222959631252,FALSE +"HCC44","Pearson.est","HMGCR inhibitor",-0.27223,-0.668,0.878,786,0.932,"mevastatin, pitavastatin, fluvastatin, simvastatin",0.0565054840938974,0.0305840876460186,FALSE +"HCC44","Pearson.est","HSP inhibitor",-0.44079,-1.09,0.374,1111,0.808,"PU.H71, SNX.5422, SNX.2112, ganetespib, NVP.AUY922, BIIB021",0.42712839779952,0.0925886392254138,FALSE +"HCC44","Pearson.est","JAK inhibitor",0.27556,0.765,0.727,164,0.987,"PRT062070, TG.101348, LY2784544, TG.101209, TG.02",0.138465589140962,0.00568284733036327,FALSE +"HCC44","Pearson.est","KIT inhibitor",0.17863,0.499,0.977,83,1,"cediranib, lenvatinib",0.0101054362812269,0,FALSE +"HCC44","Pearson.est","MDM inhibitor",-0.60825,-1.51,0.0723,1000,0.342,"serdemetan, nutlin.3, CGM097, idasanutlin",1.14086170270547,0.465973893943865,FALSE +"HCC44","Pearson.est","MEK inhibitor",-0.66832,-1.63,0.0473,1207,0.239,"PD.318088, PD.184352, PD.198306, MEK162, AS.703026, AZD8330, PD.98059, TAK.733, cobimetinib, PD.0325901, trametinib, Ro.4987655, refametinib",1.32513885926219,0.621602099051862,TRUE +"HCC44","Pearson.est","MET inhibitor",-0.677,-1.65,0.0198,1094,0.244,"AMG458, PHA.665752, LY2801653, PF.04217903",1.70333480973847,0.612610173661271,TRUE +"HCC44","Pearson.est","microtubule inhibitor",-0.32959,-0.827,0.661,895,1,"cytochalasin.b, podophyllotoxin, secnidazole, cabazitaxel, D.64131, vinflunine, vinblastine",0.17979854051436,0,FALSE +"HCC44","Pearson.est","mTOR inhibitor",-0.30552,-0.75,0.758,1037,0.978,"AZD2014, PI.103, LY3023414, GSK2126458, MLN0128, PP242, LY303511, ku.0063794, NVP.BEZ235",0.120330794367946,0.00966114521239857,FALSE +"HCC44","Pearson.est","NFkB pathway inhibitor",0.34575,0.947,0.498,2,0.834,"tyloxapol",0.302770657240282,0.0788339493622613,FALSE +"HCC44","Pearson.est","opioid receptor agonist",-0.63262,-1.56,0.0353,1078,0.286,"trimebutine, spiradoline, BW.180C",1.45222529461218,0.543633966870957,FALSE +"HCC44","Pearson.est","p38 MAPK inhibitor",-0.39882,-0.991,0.471,1195,0.839,"VX.702, CMPD.1",0.326979092871104,0.0762380391712997,FALSE +"HCC44","Pearson.est","PARP inhibitor",-0.59723,-1.45,0.099,1353,0.357,"niraparib, talazoparib, olaparib",1.00436480540245,0.447331783887807,FALSE +"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.18705,0.523,0.975,83,1,"orantinib, lenvatinib",0.0109953843014632,0,FALSE +"HCC44","Pearson.est","phosphatase inhibitor",0.32994,0.919,0.483,292,0.848,"menadione, mycophenolate.mofetil, BVT.948, GSK2830371",0.316052869248488,0.0716041477432862,FALSE +"HCC44","Pearson.est","phosphodiesterase inhibitor",0.19974,0.56,0.96,150,1,"avanafil, enoximone",0.0177287669604316,0,FALSE +"HCC44","Pearson.est","PI3K inhibitor",-0.29175,-0.716,0.82,957,0.936,"alpelisib, GDC.0980, buparlisib, PI.103, LY3023414, PIK.75, GDC.0941, TG.100713, GSK2126458, LY303511, NVP.BEZ235",0.0861861476162833,0.0287241512618947,FALSE +"HCC44","Pearson.est","PLK inhibitor",-0.75955,-1.92,0.00298,1144,0.142,"rigosertib, HMN.214, GSK461364, BI.2536, volasertib, GW.843682X",2.52578373592374,0.847711655616944,TRUE +"HCC44","Pearson.est","potassium channel blocker",-0.29228,-0.718,0.792,1316,0.955,"meglitinide",0.101274818410506,0.0199966284162537,FALSE +"HCC44","Pearson.est","PPAR receptor agonist",0.71422,2,0.00329,88,0.0954,"S26948, GW.501516, pterostilbene",2.48280410205003,1.0204516252959,TRUE +"HCC44","Pearson.est","progesterone receptor agonist",0.25732,0.73,0.753,301,0.967,"norethindrone.acetate, norgestrel, norethindrone, levonorgestrel",0.123205023799299,0.0145735259169983,FALSE +"HCC44","Pearson.est","proteasome inhibitor",0.16875,0.47,1,1205,0.99,"oprozomib, ONX.0914, carfilzomib, ixazomib.citrate, delanzomib, MG.132, bortezomib, ixazomib",0,0.00436480540245009,FALSE +"HCC44","Pearson.est","protein synthesis inhibitor",-0.31457,-0.787,0.712,1036,0.995,"brefeldin.a, emetine, thiostrepton, mercaptopurine, cycloheximide",0.147520006363144,0.00217691925427455,FALSE +"HCC44","Pearson.est","protein tyrosine kinase inhibitor",0.3125,0.907,0.572,272,0.828,"CP.724714, PP.121, AV.412",0.242603971206976,0.0819696632151199,FALSE +"HCC44","Pearson.est","RAF inhibitor",-0.3116,-0.769,0.739,768,0.997,"AZ.628, PLX.4720, SB.590885, vemurafenib, dabrafenib, RAF265, LGX818",0.131355561605174,0.00130484168834428,FALSE +"HCC44","Pearson.est","RET tyrosine kinase inhibitor",-0.43198,-1.06,0.404,1345,0.779,"cabozantinib",0.393618634889395,0.108462542327436,FALSE +"HCC44","Pearson.est","retinoid receptor agonist",-0.37587,-0.924,0.55,1150,0.925,"tamibarotene, AM.580, adapalene",0.259637310505756,0.0338582672609674,FALSE +"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.56925,-1.41,0.109,1074,0.376,"gemcitabine, cladribine, hydroxyurea, triapine, fludarabine, fludarabine.phosphate, clofarabine",0.962573502059376,0.424812155072339,FALSE +"HCC44","Pearson.est","serotonin receptor agonist",-0.23662,-0.591,0.93,1252,0.964,"SR.57227A",0.0315170514460649,0.0159229660971692,FALSE +"HCC44","Pearson.est","serotonin receptor antagonist",-0.36794,-0.922,0.55,1133,0.899,"pirenperone, RS.16566, SB.216641, SB.200646",0.259637310505756,0.0462403082667712,FALSE +"HCC44","Pearson.est","sodium channel blocker",-0.22155,-0.545,0.963,958,0.974,"mexiletine, benzocaine, ajmaline, butamben",0.0163737128754655,0.0114410431213845,FALSE +"HCC44","Pearson.est","src inhibitor",0.36717,1.03,0.386,175,0.714,"saracatinib, ZM.306416, PP.1",0.413412695328245,0.146301788223826,FALSE +"HCC44","Pearson.est","sterol demethylase inhibitor",-0.59972,-1.5,0.0697,1367,0.327,"lanoconazole, chlormidazole",1.15676722190199,0.485452247339714,FALSE +"HCC44","Pearson.est","TGF beta receptor inhibitor",0.93962,2.61,0,90,0,"SB.525334, SB.431542, repsox, adaprev, LY2109761",Inf,Inf,TRUE +"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.51819,-1.28,0.184,1065,0.517,"ftorafur, carmofur, raltitrexed, trifluridine",0.735182176990464,0.286509456906058,FALSE +"HCC44","Pearson.est","topoisomerase inhibitor",-0.76735,-1.89,0.00295,1292,0.0966,"irinotecan, teniposide, camptothecin, nemorubicin, valrubicin, amonafide, topotecan, SN.38, etoposide, mitoxantrone, exatecan.mesylate, idarubicin, TAS.103, rubitecan, genz.644282, voreloxin, amsacrine",2.53017798402184,1.01502287358451,TRUE +"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.51384,-1.27,0.196,1172,0.511,"taltobulin, oxibendazole, mebendazole, paclitaxel, docetaxel, fenbendazole, vinblastine, verubulin, fosbretabulin, BNC105, epothilone.b",0.707743928643524,0.291579099865287,FALSE +"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.30908,-0.766,0.763,1027,0.977,"aminopurvalanol.a, dasatinib, UNC2250, tyrphostin.AG.99, bafetinib, cabozantinib, NVP.TAE226, AMG.208",0.11747546204512,0.0101054362812269,FALSE +"HCC44","Pearson.est","VEGFR inhibitor",0.27516,0.753,0.73,125,0.968,"orantinib, AEE788, cediranib, PD.173074, lenvatinib, ZM.306416, BMS.690514",0.136677139879544,0.0141246426916063,FALSE +"HCC44","Pearson.est","vitamin D receptor agonist",0.4202,1.16,0.293,203,0.771,"maxacalcitol, paricalcitol, alfacalcidol",0.533132379645891,0.112945621949043,FALSE +"H1299","Pearson.est","EGFR inhibitor",0.64054,1.58,0.0663,311,0.504,"erlotinib, WZ8040, OSI.420, osimertinib, PD.168393, pelitinib, BIBU.1361, icotinib, CP.724714, canertinib, BMS.690514, afatinib, dacomitinib, gefitinib, XL.647, tyrphostin.AG.1478, AZD8931, ARRY.334543, rociletinib, AEE788, vandetanib, BIBX.1382, PD.153035, lapatinib, poziotinib, CNX.2006",1.17848647159523,0.297569463554475,FALSE +"H1299","Pearson.est","Abl kinase inhibitor",0.20663,0.504,0.984,499,0.978,"ZM.306416, imatinib, KW.2449, bosutinib, metatinib",0.00700490156865849,0.00966114521239857,FALSE +"H1299","Pearson.est","acetylcholine receptor agonist",-0.38866,-1.01,0.423,1322,0.686,"nicotine, xanomeline",0.373659632624958,0.163675884293248,FALSE +"H1299","Pearson.est","acetylcholine receptor antagonist",0.25279,0.623,0.917,375,0.982,"darifenacin, diphemanil, dicycloverine",0.0376306643299789,0.00788851221305034,FALSE +"H1299","Pearson.est","adenosine receptor antagonist",0.84647,2.11,0,152,0.0159,"CGS.15943, SCH.58261, MRS.1220, PSB.1115",Inf,1.79860287567955,TRUE +"H1299","Pearson.est","adrenergic receptor agonist",0.32889,0.811,0.699,560,0.953,"oxymetazoline, A61603, isoetharine, clenbuterol, methyldopa, buphenine, isoxsuprine, metaraminol",0.155522824254319,0.0209070993616736,FALSE +"H1299","Pearson.est","adrenergic receptor antagonist",0.26757,0.668,0.832,107,1,"atenolol...., dronedarone, RS.17053",0.0798766737092761,0,FALSE +"H1299","Pearson.est","AKT inhibitor",0.55536,1.37,0.146,266,0.489,"CCT128930, palomid.529, GSK2110183, AZD5363",0.835647144215563,0.31069114087638,FALSE +"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.43565,1.08,0.367,388,0.752,"NVP.TAE684, GW.788388, SB.505124, AZD3463, alectinib, AP26113",0.435333935747911,0.123782159408358,FALSE +"H1299","Pearson.est","androgen receptor antagonist",-0.29994,-0.791,0.668,980,0.88,"RU.58841, nilutamide, enzalutamide",0.175223537524454,0.0555173278498314,FALSE +"H1299","Pearson.est","antioxidant",0.25427,0.629,0.893,378,1,"benfotiamine, taurine",0.0491485411114536,0,FALSE +"H1299","Pearson.est","AP inhibitor",0.39624,0.988,0.453,475,0.924,"birinapant, embelin, tanshinone.i, LCL.161",0.343901797987168,0.0343280287798933,FALSE +"H1299","Pearson.est","ATPase inhibitor",-0.76696,-2.03,0.0026,1307,0.161,"rabeprazole, digitoxigenin, evodiamine, thonzonium, oligomycin.a, digoxin, k.strophanthidin",2.58502665202918,0.79317412396815,TRUE +"H1299","Pearson.est","Aurora kinase inhibitor",-0.40706,-1.07,0.354,931,0.652,"MK.8745, hesperadin, tozasertib, GSK1070916, barasertib, SNS.314, ENMD.2076, CCT137690, TAK.901, MK.5108, AT.9283, AMG900, aurora.a.inhibitor.i",0.450996737974212,0.18575240426808,FALSE +"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.43398,-1.15,0.304,1144,0.671,"valnemulin, josamycin",0.517126416391246,0.173277479831008,FALSE +"H1299","Pearson.est","bacterial DNA gyrase inhibitor",-0.44109,-1.16,0.266,1262,0.702,"norfloxacin, lomefloxacin",0.575118363368933,0.153662887870195,FALSE +"H1299","Pearson.est","BCL inhibitor",-0.39063,-1.03,0.365,964,0.686,"obatoclax, venetoclax, TW.37, ABT.737, gossypol",0.437707135543525,0.163675884293248,FALSE +"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.24282,-0.658,0.876,1176,0.951,"ponatinib, GZD824",0.0574958938319193,0.0218194830625861,FALSE +"H1299","Pearson.est","benzodiazepine receptor agonist",0.56436,1.4,0.117,287,0.502,"lorazepam, nefiracetam, gamma.aminobutyric.acid, CGS.20625, zaleplon, piperazine",0.931814138253838,0.299296282854981,FALSE +"H1299","Pearson.est","bromodomain inhibitor",0.4892,1.2,0.255,729,0.632,"JQ1...., I.BET151, OTX015, I.BET.762, bromosporine",0.593459819566045,0.199282921717615,FALSE +"H1299","Pearson.est","calcium channel blocker",0.25722,0.644,0.886,602,1,"cinnarazine, SR.33805, fendiline, efonidipine.monoethanolate, pranidipine, mibefradil",0.0525662781129492,0,FALSE +"H1299","Pearson.est","CC chemokine receptor antagonist",-0.46565,-1.21,0.231,1335,0.79,"ZK811752, UNBS.5162, SB.225002",0.636388020107856,0.102372908709559,FALSE +"H1299","Pearson.est","CDK inhibitor",0.22298,0.552,0.959,551,1,"arcyriaflavin.a, indirubin, BMS.387032, kenpaullone, TG.02, indisulam, AZD5438, ribociclib, alvocidib, JNJ.7706621",0.0181813928293364,0,FALSE +"H1299","Pearson.est","CHK inhibitor",0.33588,0.831,0.637,964,0.972,"LY2603618, CHIR.124, AZD7762, SCH.900776, SB.218078, LY2606368, PF.477736",0.19586056766465,0.0123337350737254,FALSE +"H1299","Pearson.est","cyclooxygenase inhibitor",0.37036,0.92,0.561,424,0.977,"tryptanthrin, FR.122047, indoprofen, phenylbutazone, suxibuzone, ramifenazone, metoxibutropate, ketoprofen, pterostilbene, meloxicam, FK.3311, AM.404",0.251037138743839,0.0101054362812269,FALSE +"H1299","Pearson.est","cytochrome P450 inhibitor",0.51937,1.28,0.191,244,0.564,"morin, PF.4981517, itraconazole",0.718966632752272,0.248720896016658,FALSE +"H1299","Pearson.est","DNA alkylating agent",0.28248,0.709,0.8,261,1,"ifosfamide, streptozotocin, TH.302, dacarbazine",0.0969100130080564,0,FALSE +"H1299","Pearson.est","DNA inhibitor",-0.46603,-1.23,0.229,1264,0.826,"mechlorethamine, carboplatin, carmustine, chlorambucil, sangivamycin, metronidazole",0.640164517660112,0.0830199526796178,FALSE +"H1299","Pearson.est","DNA methyltransferase inhibitor",0.53737,1.33,0.16,416,0.529,"azacitidine, RG108, SGI.1027, fdcyd",0.795880017344075,0.276544327964814,FALSE +"H1299","Pearson.est","DNA polymerase inhibitor",-0.51109,-1.35,0.165,1179,1,"adefovir.dipivoxil, foscarnet, trifluridine",0.782516055786094,0,FALSE +"H1299","Pearson.est","DNA synthesis inhibitor",0.26921,0.676,0.854,389,1,"estramustine.phosphate, capecitabine, altretamine, floxuridine",0.068542129310995,0,FALSE +"H1299","Pearson.est","dopamine receptor antagonist",0.28252,0.707,0.818,326,1,"ziprasidone, acetophenazine, nemonapride, isofloxythepin, lurasidone, mesoridazine, amisulpride",0.087246696328677,0,FALSE +"H1299","Pearson.est","estrogen receptor agonist",-0.36767,-0.97,0.447,1067,0.664,"ethinyl.estradiol, equol, levonorgestrel, estrone",0.349692476868064,0.177831920631982,FALSE +"H1299","Pearson.est","estrogen receptor antagonist",-0.36938,-0.978,0.478,1385,0.68,"toremifene",0.320572103387881,0.167491087293764,FALSE +"H1299","Pearson.est","FGFR inhibitor",0.39288,0.982,0.481,22,0.903,"PD.173074, orantinib",0.317854923626168,0.0443122496864942,FALSE +"H1299","Pearson.est","FLT3 inhibitor",-0.33624,-0.868,0.591,1065,0.812,"GTP.14564, gilteritinib, ENMD.2076, TG.101348, ponatinib, sorafenib, dovitinib, tyrphostin.AG.1296",0.228412519118745,0.0904439707588247,FALSE +"H1299","Pearson.est","glucocorticoid receptor agonist",0.34096,0.842,0.649,567,1,"betamethasone, rimexolone, flumethasone, fludroxycortide, clobetasol.propionate, triamcinolone.acetonide, prednisolone.hemisuccinate, prednisolone.acetate, deflazacort, ciclesonide, fluocinolone.acetonide, halobetasol.propionate, halcinonide, methylprednisolone, flumethasone.pivalate",0.187755303199631,0,FALSE +"H1299","Pearson.est","glutamate receptor antagonist",0.48444,1.18,0.265,518,0.61,"latrepirdine, MTPG, SIB.1757, kynurenic.acid, CPP, LY456236, diazooxonorleucine, ACDPP",0.576754126063192,0.214670164989233,FALSE +"H1299","Pearson.est","glycogen synthase kinase inhibitor",0.60282,1.51,0.0672,262,0.398,"LY2090314, indirubin, GSK.3.inhibitor.IX, CHIR.99021, kenpaullone",1.17263072694617,0.400116927926312,FALSE +"H1299","Pearson.est","growth factor receptor inhibitor",0.34382,0.868,0.606,494,1,"GSK1904529A, AZD3463, GSK1838705A, GW.441756",0.217527375833714,0,FALSE +"H1299","Pearson.est","HCV inhibitor",0.67882,1.69,0.0342,319,0.31,"Ro.9187, daclatasvir, embelin, PSI.7976",1.46597389394386,0.508638306165727,FALSE +"H1299","Pearson.est","HDAC inhibitor",0.63369,1.57,0.0576,445,0.445,"nexturastat.a, JNJ.26481585, tacedinaline, R306465, romidepsin, SB.939, panobinostat, pyroxamide, RG2833, entinostat, PCI.24781, M.344, resminostat, vorinostat, RGFP966, chidamide",1.23957751657679,0.351639989019068,FALSE +"H1299","Pearson.est","histamine receptor antagonist",0.52801,1.31,0.165,505,0.534,"terfenadine, levocetirizine, astemizole, tecastemizole, zolantidine, epinastine, ebastine, tiotidine, cyproheptadine, pheniramine, ICI.162846, ranitidine, BF2.649",0.782516055786094,0.272458742971444,FALSE +"H1299","Pearson.est","HMGCR inhibitor",-0.40693,-1.07,0.34,1001,0.652,"fluvastatin, atorvastatin, lovastatin",0.468521082957745,0.18575240426808,FALSE +"H1299","Pearson.est","HSP inhibitor",0.33103,0.822,0.667,301,0.96,"alvespimycin, SNX.5422, tanespimycin, VER.49009",0.175874166083451,0.0177287669604316,FALSE +"H1299","Pearson.est","JAK inhibitor",0.2235,0.548,0.966,450,0.998,"pacritinib, LY2784544, atiprimod, TG.02, PRT062070, WHI.P154",0.0150228735845067,0.000869458712628891,FALSE +"H1299","Pearson.est","KIT inhibitor",-0.2731,-0.721,0.788,1225,0.93,"regorafenib, pazopanib, sorafenib, lenvatinib",0.103473782510445,0.0315170514460649,FALSE +"H1299","Pearson.est","MDM inhibitor",0.71946,1.79,0.0159,302,0.3,"CGM097, RITA, serdemetan, nutlin.3",1.79860287567955,0.522878745280338,FALSE +"H1299","Pearson.est","MEK inhibitor",0.36941,0.913,0.547,141,0.958,"nobiletin, BIX.02188, arctigenin",0.262012673666569,0.0186344909214556,FALSE +"H1299","Pearson.est","MET inhibitor",-0.66925,-1.77,0.0178,1419,0.226,"LY2801653",1.74957999769111,0.645891560852599,TRUE +"H1299","Pearson.est","microtubule inhibitor",-0.40164,-1.09,0.33,1114,0.693,"cabazitaxel, D.64131, vinflunine, secnidazole, vinblastine",0.481486060122112,0.159266765388193,FALSE +"H1299","Pearson.est","mTOR inhibitor",-0.23731,-0.617,0.908,1135,0.965,"WYE.354, MLN0128, voxtalisib, PKI.179, AZD2014, OSI.027, SB.2343, ku.0063794, PF.04691502",0.0419141514789149,0.0154726866562074,FALSE +"H1299","Pearson.est","NFkB pathway inhibitor",-0.23978,-0.61,0.903,1420,0.942,"EVP4593",0.0443122496864942,0.0259490972071227,FALSE +"H1299","Pearson.est","opioid receptor agonist",-0.28628,-0.756,0.744,1353,0.906,"trimebutine",0.128427064454121,0.0428718023231869,FALSE +"H1299","Pearson.est","p38 MAPK inhibitor",0.43941,1.09,0.351,574,0.763,"SB.239063, SB.242235, VX.702, skepinone.l, TAK.715",0.454692883534176,0.11747546204512,FALSE +"H1299","Pearson.est","PARP inhibitor",0.62121,1.53,0.0512,533,0.463,"endo.IWR.1, PJ.34, AG.14361, E7449, talazoparib, AZD2461, niraparib",1.29073003902417,0.334419008982047,FALSE +"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.31484,-0.818,0.676,1154,0.867,"axitinib, ponatinib, regorafenib, pazopanib, sorafenib, lenvatinib, linifanib, dovitinib, nintedanib",0.170053304058364,0.0619809025237897,FALSE +"H1299","Pearson.est","phosphatase inhibitor",-0.37648,-0.978,0.448,1277,0.68,"GSK2830371, bis.maltolato.oxovanadium.IV., alexidine",0.348721986001856,0.167491087293764,FALSE +"H1299","Pearson.est","phosphodiesterase inhibitor",0.704,1.73,0.0146,380,0.318,"GSK256066, papaverine, cilostamide, YM.976, zardaverine, anagrelide, trequinsin, EMD.53998",1.83564714421556,0.497572880015567,FALSE +"H1299","Pearson.est","PI3K inhibitor",-0.21296,-0.563,0.95,1184,0.95,"voxtalisib, PKI.179, SB.2343, buparlisib, PF.04691502, GDC.0941",0.0222763947111523,0.0222763947111523,FALSE +"H1299","Pearson.est","PLK inhibitor",-0.70854,-1.85,0.0212,1021,0.289,"GSK461364, BI.2536, HMN.214, rigosertib, NMS.1286937, volasertib, GW.843682X",1.67366413907125,0.539102157243452,FALSE +"H1299","Pearson.est","potassium channel blocker",0.50103,1.24,0.219,85,0.579,"oleoylethanolamide",0.659555885159882,0.237321436272564,FALSE +"H1299","Pearson.est","PPAR receptor agonist",0.47121,1.18,0.257,213,0.61,"S26948, oleoylethanolamide, ciprofibrate",0.590066876668705,0.214670164989233,FALSE +"H1299","Pearson.est","progesterone receptor agonist",-0.45366,-1.19,0.243,1256,0.697,"norethindrone, levonorgestrel, tanaproget, nomegestrol.acetate",0.614393726401688,0.156767221901991,FALSE +"H1299","Pearson.est","proteasome inhibitor",0.20756,0.522,0.958,479,0.991,"ixazomib.citrate, oprozomib, ONX.0914",0.0186344909214556,0.00392634551472468,FALSE +"H1299","Pearson.est","protein synthesis inhibitor",-0.41791,-1.1,0.338,1222,0.719,"bruceantin, mercaptopurine, anguidine, harringtonine, cycloheximide, clofoctol, chloramphenicol.palmitate",0.471083299722345,0.143271109617117,FALSE +"H1299","Pearson.est","protein tyrosine kinase inhibitor",0.34052,0.832,0.672,158,1,"CP.724714, NVP.TAE226",0.172630726946175,0,FALSE +"H1299","Pearson.est","RAF inhibitor",0.30092,0.737,0.777,104,1,"GDC.0879, CEP.32496",0.109578981199086,0,FALSE +"H1299","Pearson.est","RET tyrosine kinase inhibitor",0.33661,0.837,0.666,209,1,"apatinib, vandetanib",0.176525770829699,0,FALSE +"H1299","Pearson.est","retinoid receptor agonist",-0.50954,-1.33,0.153,1432,0.775,"adapalene, fenretinide",0.815308569182401,0.11069829749369,FALSE +"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.45317,-1.19,0.268,1230,0.697,"hydroxyurea, triapine, pentostatin",0.571865205971211,0.156767221901991,FALSE +"H1299","Pearson.est","serotonin receptor agonist",0.59688,1.49,0.0805,54,0.4,"ipsapirone, aripiprazole",1.09420411963213,0.397940008672038,FALSE +"H1299","Pearson.est","serotonin receptor antagonist",0.50766,1.26,0.237,110,0.572,"SB.228357, aripiprazole, ziprasidone",0.625251653989896,0.242603971206976,FALSE +"H1299","Pearson.est","sodium channel blocker",-0.25437,-0.663,0.888,1254,0.978,"oxcarbazepine, cibenzoline, benzocaine",0.051587034221399,0.00966114521239857,FALSE +"H1299","Pearson.est","src inhibitor",0.60044,1.51,0.0824,268,0.398,"saracatinib, PP.2, PP.1, ZM.306416",1.08407278830288,0.400116927926312,FALSE +"H1299","Pearson.est","sterol demethylase inhibitor",-0.68308,-1.82,0.0102,1268,0.232,"lanoconazole, posaconazole, sulconazole, chlormidazole",1.99139982823808,0.6345120151091,TRUE +"H1299","Pearson.est","TGF beta receptor inhibitor",0.58713,1.47,0.0808,241,0.399,"LY2109761, D.4476, repsox",1.09258863922541,0.399027104313252,FALSE +"H1299","Pearson.est","thymidylate synthase inhibitor",0.38111,0.937,0.534,345,0.974,"doxifluridine, capecitabine, raltitrexed, carmofur",0.272458742971444,0.0114410431213845,FALSE +"H1299","Pearson.est","topoisomerase inhibitor",-0.49658,-1.34,0.122,1162,0.872,"amsacrine, daunorubicin, idarubicin, voreloxin, TAS.103, SN.38, epirubicin, topotecan, dexrazoxane, etoposide.phosphate, doxorubicin, mitoxantrone",0.913640169325252,0.0594835150674328,FALSE +"H1299","Pearson.est","tubulin polymerization inhibitor",-0.49795,-1.3,0.168,1053,0.745,"ABT.751, indibulin, vincristine, epothilone.b, oxibendazole, verubulin, mebendazole, docetaxel, vinblastine, BNC105, paclitaxel, vindesine, fenbendazole",0.774690718274137,0.127843727251707,FALSE +"H1299","Pearson.est","tyrosine kinase inhibitor",0.26385,0.651,0.876,209,1,"CP.724714, NVP.TAE226, apatinib, vandetanib",0.0574958938319193,0,FALSE +"H1299","Pearson.est","VEGFR inhibitor",0.24707,0.625,0.922,209,1,"PD.173074, orantinib, BMS.690514, vatalanib, XL.647, AEE788, vandetanib",0.0352690789463706,0,FALSE +"H1299","Pearson.est","vitamin D receptor agonist",0.55076,1.39,0.116,400,0.485,"maxacalcitol, ercalcitriol, tacalcitol, calcitriol",0.935542010773082,0.314258261397736,FALSE +"H1703","Pearson.est","EGFR inhibitor",0.32472,0.791,0.707,359,0.919,"WZ8040, BIBU.1361, TAK.285, erlotinib, icotinib, BMS.599626, tyrphostin.AG.1478, OSI.420, pelitinib, osimertinib, lapatinib, vandetanib, afatinib, gefitinib, PD.168393, rociletinib, canertinib",0.150580586203101,0.0366844886138887,FALSE +"H1703","Pearson.est","Abl kinase inhibitor",0.3655,0.893,0.572,436,0.924,"imatinib, tozasertib, bafetinib, metatinib, KW.2449",0.242603971206976,0.0343280287798933,FALSE +"H1703","Pearson.est","acetylcholine receptor agonist",-0.46098,-1.19,0.255,1143,0.695,"nicotine, xanomeline",0.593459819566045,0.158015195409886,FALSE +"H1703","Pearson.est","acetylcholine receptor antagonist",-0.33306,-0.872,0.603,1112,1,"iododexetimide, hyoscyamine, methscopolamine",0.219682687859849,0,FALSE +"H1703","Pearson.est","adenosine receptor antagonist",0.59302,1.51,0.0785,524,0.566,"CGS.15943, sulmazole, SCH.58261, MRS.1220",1.10513034325475,0.247183568811729,FALSE +"H1703","Pearson.est","adrenergic receptor agonist",0.3026,0.757,0.759,480,0.929,"oxymetazoline, epinephrine, clenbuterol, isoxsuprine, terbutaline, A61603, norepinephrine",0.11975822410452,0.0319842860063582,FALSE +"H1703","Pearson.est","adrenergic receptor antagonist",-0.26373,-0.696,0.829,1147,0.986,"prazosin, atenolol......, naftidrofuryl, dihydroergocristine, metoprolol, atipamezole",0.0814454694497265,0.0061230850587888,FALSE +"H1703","Pearson.est","AKT inhibitor",0.61511,1.5,0.0855,97,0.461,"palomid.529, triciribine, uprosertib, CCT128930",1.06803388527183,0.336299074610352,FALSE +"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.33758,0.856,0.627,254,0.945,"NVP.TAE684, GW.788388",0.202732459169284,0.0245681914907371,FALSE +"H1703","Pearson.est","androgen receptor antagonist",-0.23529,-0.607,0.919,1180,0.983,"flutamide, RU.58841",0.0366844886138887,0.00744648216786438,FALSE +"H1703","Pearson.est","antioxidant",-0.57764,-1.49,0.101,1422,0.557,"trolox",0.995678626217357,0.254144804826271,FALSE +"H1703","Pearson.est","AP inhibitor",0.51332,1.29,0.186,186,0.526,"embelin, LCL.161, GDC.0152",0.730487055782084,0.279014255846261,FALSE +"H1703","Pearson.est","ATPase inhibitor",-0.75157,-1.95,0.00465,1280,0.224,"blebbistatin...., NMS.873, evodiamine, digoxin, oligomycin.a, k.strophanthidin",2.33254704711005,0.649751981665837,TRUE +"H1703","Pearson.est","Aurora kinase inhibitor",-0.26049,-0.665,0.874,1194,0.954,"TAK.901, CYC116, CCT129202, PHA.680632, AT.9283, aurora.a.inhibitor.i",0.058488567365597,0.0204516252959049,FALSE +"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.45731,-1.2,0.251,1427,0.742,"josamycin",0.600326278518962,0.129596094720973,FALSE +"H1703","Pearson.est","bacterial DNA gyrase inhibitor",-0.38722,-1.02,0.404,1183,0.873,"norfloxacin, lomefloxacin, nadifloxacin",0.393618634889395,0.0589857562944303,FALSE +"H1703","Pearson.est","BCL inhibitor",-0.47606,-1.23,0.234,1120,0.846,"obatoclax, TW.37, ABT.737, gossypol",0.630784142589857,0.0726296369609765,FALSE +"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.45954,1.12,0.332,420,0.709,"imatinib, tozasertib, bafetinib, metatinib",0.478861916295964,0.149353764816933,FALSE +"H1703","Pearson.est","benzodiazepine receptor agonist",0.30115,0.749,0.778,487,0.921,"zaleplon, piperazine, CGS.20625, eprinomectin, lorazepam, ivermectin",0.109020403010311,0.0357403698031511,FALSE +"H1703","Pearson.est","bromodomain inhibitor",0.40894,1.04,0.364,507,0.787,"JQ1...., I.BET.762, bromosporine, OTX015",0.438898616350944,0.104025267640935,FALSE +"H1703","Pearson.est","calcium channel blocker",-0.40474,-1.04,0.356,1010,0.893,"tetrandrine, fendiline, efonidipine.monoethanolate, mibefradil, carboxyamidotriazole",0.448550002027125,0.0491485411114536,FALSE +"H1703","Pearson.est","CC chemokine receptor antagonist",0.36085,0.9,0.561,1,0.938,"navarixin",0.251037138743839,0.0277971616209356,FALSE +"H1703","Pearson.est","CDK inhibitor",0.31086,0.765,0.746,503,0.939,"alvocidib, AZD5438, arcyriaflavin.a, kenpaullone, BMS.387032, PHA.793887, TG.02, JNJ.7706621, P276.00",0.127261172527331,0.0273344077338891,FALSE +"H1703","Pearson.est","CHK inhibitor",0.54089,1.31,0.168,434,0.547,"LY2606368, SCH.900776, LY2603618, CHIR.124",0.774690718274137,0.262012673666569,FALSE +"H1703","Pearson.est","cyclooxygenase inhibitor",0.40548,1,0.423,392,0.842,"indoprofen, amfenac, meloxicam, FK.3311, FR.122047, tryptanthrin, acetylsalicylsalicylic.acid, metoxibutropate, ramifenazone, curcumin, AM.404, aspirin",0.373659632624958,0.0746879085003505,FALSE +"H1703","Pearson.est","cytochrome P450 inhibitor",0.38756,0.954,0.518,53,0.88,"itraconazole",0.285670240254767,0.0555173278498314,FALSE +"H1703","Pearson.est","DNA alkylating agent",0.43589,1.08,0.361,501,0.759,"dacarbazine, TH.302, dianhydrogalactitol, streptozotocin, ifosfamide, cisplatin, estramustine, melphalan",0.442492798094342,0.11975822410452,FALSE +"H1703","Pearson.est","DNA inhibitor",0.35448,0.9,0.559,12,0.938,"busulfan, nithiamide",0.252588192113577,0.0277971616209356,FALSE +"H1703","Pearson.est","DNA methyltransferase inhibitor",0.51136,1.28,0.195,365,0.517,"azacitidine, fdcyd, SGI.1027, decitabine",0.709965388637482,0.286509456906058,FALSE +"H1703","Pearson.est","DNA polymerase inhibitor",-0.31042,-0.804,0.692,447,0.886,"famciclovir, cephalomannine, cidofovir, idoxuridine, trifluridine, foscarnet, adefovir.dipivoxil, menadione",0.159893905543242,0.0525662781129492,FALSE +"H1703","Pearson.est","DNA synthesis inhibitor",0.25692,0.634,0.911,415,1,"altretamine, floxuridine, estramustine.phosphate, anisomycin, cisplatin",0.0404816230270017,0,FALSE +"H1703","Pearson.est","dopamine receptor antagonist",0.31464,0.791,0.677,305,0.919,"isofloxythepin, ziprasidone, acetophenazine, oxiperomide, mesoridazine, amisulpride",0.169411331314856,0.0366844886138887,FALSE +"H1703","Pearson.est","estrogen receptor agonist",-0.31055,-0.821,0.662,1170,0.938,"levonorgestrel, estrone, erteberel",0.1791420105603,0.0277971616209356,FALSE +"H1703","Pearson.est","estrogen receptor antagonist",0.34045,0.838,0.65,446,0.928,"raloxifene, toremifene",0.187086643357144,0.0324520237811379,FALSE +"H1703","Pearson.est","FGFR inhibitor",-0.3347,-0.856,0.596,1246,1,"dovitinib, nintedanib, erdafitinib",0.224753740259764,0,FALSE +"H1703","Pearson.est","FLT3 inhibitor",0.32847,0.825,0.655,122,0.903,"tandutinib, sunitinib, pacritinib",0.183758700008217,0.0443122496864942,FALSE +"H1703","Pearson.est","glucocorticoid receptor agonist",-0.56219,-1.44,0.105,1133,0.561,"methylprednisolone, fluocinolone.acetonide, betamethasone, deflazacort, fluticasone.propionate, triamcinolone, clobetasol.propionate, flumethasone.pivalate, halcinonide, triamcinolone.acetonide, dexamethasone.acetate, desonide, beclomethasone.dipropionate, hydrocortisone",0.978810700930062,0.251037138743839,FALSE +"H1703","Pearson.est","glutamate receptor antagonist",0.56339,1.42,0.107,102,0.461,"diazooxonorleucine, latrepirdine, SIB.1757, MTPG",0.97061622231479,0.336299074610352,FALSE +"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.57909,1.44,0.113,236,0.457,"AZD2858, GSK.3.inhibitor.IX, LY2090314, kenpaullone",0.94692155651658,0.34008379993015,FALSE +"H1703","Pearson.est","growth factor receptor inhibitor",-0.26509,-0.686,0.858,382,0.963,"GW.441756, GSK1838705A, lestaurtinib, AZD3463, GSK1904529A, danusertib, PHA.848125",0.0665127121512946,0.0163737128754655,FALSE +"H1703","Pearson.est","HCV inhibitor",0.79174,1.97,0.00512,147,0.136,"embelin, Ro.9187, PSI.7976, daclatasvir",2.29073003902417,0.866461091629782,TRUE +"H1703","Pearson.est","HDAC inhibitor",0.56074,1.4,0.126,363,0.41,"JNJ.26481585, tacedinaline, SB.939, R306465, panobinostat, M.344, romidepsin, vorinostat, RG2833, PCI.24781, nexturastat.a, dacinostat, ACY.1215",0.899629454882437,0.387216143280265,FALSE +"H1703","Pearson.est","histamine receptor antagonist",0.55756,1.41,0.115,440,0.418,"chloropyramine, terfenadine, levocetirizine, zolantidine, tiotidine, tecastemizole, ICI.162846, cimetidine, ranitidine, lafutidine, astemizole",0.939302159646388,0.378823718224965,FALSE +"H1703","Pearson.est","HMGCR inhibitor",-0.32338,-0.842,0.641,1218,0.942,"atorvastatin, lovastatin",0.193141970481183,0.0259490972071227,FALSE +"H1703","Pearson.est","HSP inhibitor",0.61147,1.54,0.0667,310,0.678,"VER.49009, XL888, guanidine, SNX.5422, tanespimycin, alvespimycin, SNX.2112, BIIB021, NVP.AUY922",1.17587416608345,0.168770306132937,FALSE +"H1703","Pearson.est","JAK inhibitor",0.24143,0.6,0.922,174,0.978,"atiprimod, pacritinib, LY2784544",0.0352690789463706,0.00966114521239857,FALSE +"H1703","Pearson.est","KIT inhibitor",0.58503,1.47,0.0903,459,0.481,"tandutinib, imatinib, sunitinib, telatinib, regorafenib, vatalanib, KI.8751, OSI.930, motesanib",1.04431224968649,0.317854923626168,FALSE +"H1703","Pearson.est","MDM inhibitor",-0.27737,-0.735,0.778,1315,0.965,"AMG.232",0.109020403010311,0.0154726866562074,FALSE +"H1703","Pearson.est","MEK inhibitor",0.28311,0.706,0.82,154,0.941,"BIX.02188, nobiletin, arctigenin",0.0861861476162833,0.0264103765727431,FALSE +"H1703","Pearson.est","MET inhibitor",0.5104,1.26,0.207,712,0.5,"AMG458, INC.280, LY2801653, NVP.BVU972, PF.04217903, PHA.665752",0.684029654543082,0.301029995663981,FALSE +"H1703","Pearson.est","microtubule inhibitor",-0.21734,-0.557,0.948,1079,0.986,"triclabendazole, secnidazole, vinblastine, cytochalasin.b",0.0231916626619338,0.0061230850587888,FALSE +"H1703","Pearson.est","mTOR inhibitor",0.20568,0.503,0.985,101,1,"palomid.529, PI.103, sirolimus",0.00656376950238827,0,FALSE +"H1703","Pearson.est","NFkB pathway inhibitor",-0.47456,-1.22,0.244,1429,0.773,"tyloxapol, EVP4593",0.612610173661271,0.111820506081675,FALSE +"H1703","Pearson.est","opioid receptor agonist",0.33949,0.848,0.625,40,0.935,"salvinorin.a",0.204119982655925,0.0291883891274822,FALSE +"H1703","Pearson.est","p38 MAPK inhibitor",0.58292,1.46,0.0991,585,0.457,"CMPD.1, TAK.715, SB.239063, VX.702, skepinone.l, SB.242235",1.00392634551472,0.34008379993015,FALSE +"H1703","Pearson.est","PARP inhibitor",0.60111,1.5,0.0717,264,0.461,"PJ.34, olaparib, niraparib, talazoparib",1.1444808443322,0.336299074610352,FALSE +"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.47468,1.18,0.284,366,0.617,"tandutinib, trapidil, imatinib, sunitinib, telatinib, orantinib, regorafenib, vatalanib, KI.8751",0.546681659952962,0.209714835966758,FALSE +"H1703","Pearson.est","phosphatase inhibitor",-0.35279,-0.905,0.546,1278,1,"menadione, bis.maltolato.oxovanadium.IV., GSK2830371",0.262807357295263,0,FALSE +"H1703","Pearson.est","phosphodiesterase inhibitor",0.28406,0.707,0.817,322,0.96,"YM.976, papaverine, GSK256066, EMD.53998",0.0877779434675845,0.0177287669604316,FALSE +"H1703","Pearson.est","PI3K inhibitor",0.18908,0.474,0.983,390,1,"PI.103, CH5132799, pilaralisib, LY303511, TG.100713, PF.05212384, PIK.75, alpelisib",0.00744648216786438,0,FALSE +"H1703","Pearson.est","PLK inhibitor",-0.60044,-1.55,0.0895,1153,0.56,"GW.843682X, volasertib, NMS.1286937",1.04817696468409,0.2518119729938,FALSE +"H1703","Pearson.est","potassium channel blocker",0.69379,1.75,0.0165,141,0.307,"oleoylethanolamide, meglitinide",1.78251605578609,0.512861624522813,FALSE +"H1703","Pearson.est","PPAR receptor agonist",-0.32341,-0.85,0.607,1283,0.973,"fenofibrate, clofibrate",0.216811308924742,0.0118871597316481,FALSE +"H1703","Pearson.est","progesterone receptor agonist",-0.70415,-1.82,0.0146,1170,0.282,"levonorgestrel, nomegestrol.acetate, tanaproget, norethindrone",1.83564714421556,0.549750891680639,FALSE +"H1703","Pearson.est","proteasome inhibitor",0.69667,1.71,0.0212,348,0.313,"ixazomib.citrate, ixazomib, bortezomib, carfilzomib, delanzomib, ONX.0914",1.67366413907125,0.504455662453552,FALSE +"H1703","Pearson.est","protein synthesis inhibitor",-0.1827,-0.475,0.996,1036,0.989,"anguidine, cycloheximide, bruceantin, clindamycin.phosphate, florfenicol, clofoctol, harringtonine",0.00174066157630127,0.0048037084028206,FALSE +"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.53296,-1.41,0.114,1398,0.538,"PP.121, mubritinib",0.943095148663527,0.269217724333611,FALSE +"H1703","Pearson.est","RAF inhibitor",0.56072,1.41,0.118,176,0.418,"dabrafenib, vemurafenib, CEP.32496, AZ.628, GDC.0879",0.928117992693875,0.378823718224965,FALSE +"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.69162,1.75,0.0152,311,0.307,"apatinib, sunitinib, regorafenib, vandetanib",1.81815641205523,0.512861624522813,FALSE +"H1703","Pearson.est","retinoid receptor agonist",-0.42714,-1.12,0.313,1321,0.778,"adapalene, adarotene, fenretinide",0.504455662453552,0.109020403010311,FALSE +"H1703","Pearson.est","ribonucleotide reductase inhibitor",0.25187,0.625,0.898,409,0.995,"clofarabine, fludarabine.phosphate, fludarabine, gemcitabine, cladribine",0.0467236633326956,0.00217691925427455,FALSE +"H1703","Pearson.est","serotonin receptor agonist",-0.59237,-1.62,0.0679,1299,0.563,"aripiprazole, zolmitriptan, NAN.190",1.1681302257195,0.249491605148654,FALSE +"H1703","Pearson.est","serotonin receptor antagonist",0.39091,0.982,0.461,160,0.849,"SB.228357, RS.16566, ziprasidone",0.336299074610352,0.0710923097560473,FALSE +"H1703","Pearson.est","sodium channel blocker",-0.31453,-0.806,0.667,1118,0.922,"mepivacaine, oxcarbazepine, benzethonium, cibenzoline",0.175874166083451,0.0352690789463706,FALSE +"H1703","Pearson.est","src inhibitor",0.41694,1.05,0.386,260,0.794,"saracatinib, PP.2, KX2.391",0.413412695328245,0.100179497572904,FALSE +"H1703","Pearson.est","sterol demethylase inhibitor",-0.37949,-0.982,0.456,1160,0.902,"chlormidazole, sulconazole, posaconazole",0.341035157335565,0.0447934624580583,FALSE +"H1703","Pearson.est","TGF beta receptor inhibitor",0.50843,1.26,0.209,227,0.5,"LY2109761, D.4476, repsox",0.679853713888946,0.301029995663981,FALSE +"H1703","Pearson.est","thymidylate synthase inhibitor",0.61403,1.52,0.0802,181,0.629,"doxifluridine, carmofur, raltitrexed",1.09582563171584,0.201349354554731,FALSE +"H1703","Pearson.est","topoisomerase inhibitor",0.35817,0.892,0.56,39,0.899,"licochalcone.a, genz.644282, exatecan.mesylate",0.2518119729938,0.0462403082667712,FALSE +"H1703","Pearson.est","tubulin polymerization inhibitor",0.14999,0.377,0.998,369,0.999,"combretastatin.A.4, fosbretabulin, KX2.391, taltobulin, podophyllotoxin",0.000869458712628891,0.000434511774017692,FALSE +"H1703","Pearson.est","tyrosine kinase inhibitor",0.24227,0.605,0.916,462,0.994,"apatinib, sunitinib, BMS.599626, tivantinib, regorafenib, vandetanib, bafetinib, AMG.208, rheochrysidin, AV.412",0.0381045263321496,0.00261361560268669,FALSE +"H1703","Pearson.est","VEGFR inhibitor",0.33684,0.828,0.664,366,0.922,"MGCD.265, sunitinib, lucitanib, telatinib, golvatinib, tivozanib, orantinib, regorafenib, vandetanib, PD.173074, vatalanib, KI.8751",0.177831920631982,0.0352690789463706,FALSE +"H1703","Pearson.est","vitamin D receptor agonist",0.51401,1.3,0.176,298,0.535,"ercalcitriol, maxacalcitol, calcitriol, tacalcitol",0.75448733218585,0.271646217978772,FALSE +"H460","Pearson.est","EGFR inhibitor",0.47508,1.23,0.215,431,0.81,"AZD8931, dacomitinib, CGP.52411, poziotinib, CNX.2006, canertinib, AST.1306, afatinib, tucatinib, WZ.3146, CP.724714, pelitinib, BMS.690514, salvianolic.acid.B, gefitinib, WZ8040, GW.583340, ARRY.334543, BIBX.1382, rociletinib, FERb.033",0.667561540084395,0.0915149811213502,FALSE +"H460","Pearson.est","Abl kinase inhibitor",-0.39259,-1.01,0.443,1326,0.755,"KW.2449, GZD824, bafetinib",0.35359627377693,0.122053048370812,FALSE +"H460","Pearson.est","acetylcholine receptor agonist",-0.29863,-0.75,0.748,1320,0.811,"tremorine",0.126098402135539,0.090979145788844,FALSE +"H460","Pearson.est","acetylcholine receptor antagonist",0.72372,1.92,0.00677,204,0.178,"methscopolamine, iododexetimide, dicycloverine, hyoscyamine",2.16941133131486,0.749579997691106,TRUE +"H460","Pearson.est","adenosine receptor antagonist",0.44253,1.2,0.214,603,0.811,"istradefylline, CGS.15943, theophylline, MRS.1220, sulmazole",0.669586226650809,0.090979145788844,FALSE +"H460","Pearson.est","adrenergic receptor agonist",0.31813,0.832,0.634,358,0.932,"lidamidine, xylazine, ritodrine, isoetharine, A61603, methyldopa",0.197910742118267,0.0305840876460186,FALSE +"H460","Pearson.est","adrenergic receptor antagonist",0.35521,0.921,0.531,301,0.934,"RS.17053, atipamezole, atenolol...., prazosin, atenolol......, metoprolol, pindolol",0.274905478918531,0.0296531237699066,FALSE +"H460","Pearson.est","AKT inhibitor",-0.30832,-0.793,0.699,1294,0.81,"triciribine, GDC.0068",0.155522824254319,0.0915149811213502,FALSE +"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.4197,-1.1,0.316,1219,0.783,"AZD3463, crizotinib, alectinib",0.500312917381596,0.106238237942057,FALSE +"H460","Pearson.est","androgen receptor antagonist",0.25489,0.662,0.831,592,0.984,"flutamide, RU.58841, nilutamide, enzalutamide, cyproterone.acetate",0.080398976215889,0.00700490156865849,FALSE +"H460","Pearson.est","antioxidant",-0.44122,-1.15,0.309,1262,0.86,"chlorogenic.acid, mesna",0.510041520575165,0.0655015487564323,FALSE +"H460","Pearson.est","AP inhibitor",0.33079,0.867,0.638,971,0.972,"embelin, idronoxil, tanshinone.i, LCL.161, birinapant, GDC.0152",0.195179321278838,0.0123337350737254,FALSE +"H460","Pearson.est","ATPase inhibitor",0.4351,1.14,0.287,379,0.883,"k.strophanthidin, omeprazole, blebbistatin...., oligomycin.a, evodiamine, thonzonium",0.542118103266008,0.0540392964224314,FALSE +"H460","Pearson.est","Aurora kinase inhibitor",-0.40871,-1.05,0.378,1030,0.774,"ENMD.2076, AMG900, GSK1070916, danusertib, CCT137690, MK.8745, MK.5108, MLN.8054, hesperadin, KW.2449, PF.03814735",0.422508200162775,0.111259039317107,FALSE +"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.35567,-0.904,0.568,1357,0.792,"azalomycin.b, azithromycin",0.245651664288981,0.101274818410506,FALSE +"H460","Pearson.est","bacterial DNA gyrase inhibitor",-0.36887,-0.962,0.473,1393,0.762,"finafloxacin, novobiocin",0.325138859262188,0.1180450286604,FALSE +"H460","Pearson.est","BCL inhibitor",0.3741,1.01,0.414,330,0.864,"ABT.737, obatoclax, gossypol, navitoclax",0.382999658879101,0.0634862575211067,FALSE +"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.43596,-1.13,0.332,1332,0.854,"GZD824, bafetinib",0.478861916295964,0.068542129310995,FALSE +"H460","Pearson.est","benzodiazepine receptor agonist",0.37953,1.01,0.401,189,0.864,"temazepam, CL.218872, indiplon",0.396855627379818,0.0634862575211067,FALSE +"H460","Pearson.est","bromodomain inhibitor",0.52805,1.37,0.157,504,0.814,"I.BET151, bromosporine, I.BET.762, OTX015",0.804100347590766,0.0893755951107988,FALSE +"H460","Pearson.est","calcium channel blocker",0.52905,1.36,0.142,70,0.736,"mibefradil, efonidipine.monoethanolate, tetrandrine",0.847711655616944,0.133122185662501,FALSE +"H460","Pearson.est","CC chemokine receptor antagonist",-0.46154,-1.16,0.275,1066,0.898,"ZK811752, UNBS.5162, RS.504393, navarixin",0.560667306169737,0.0467236633326956,FALSE +"H460","Pearson.est","CDK inhibitor",-0.30725,-0.789,0.682,989,0.776,"ribociclib, JNJ.7706621, abemaciclib, arcyriaflavin.a, BMS.265246, kenpaullone, PHA.848125, alvocidib, NU6027, AZD5438",0.166215625343521,0.110138278741812,FALSE +"H460","Pearson.est","CHK inhibitor",-0.39615,-1.02,0.412,964,0.802,"SB.218078, SCH.900776, LY2603618, LY2606368",0.385102783966865,0.0958256317158365,FALSE +"H460","Pearson.est","cyclooxygenase inhibitor",-0.36854,-0.943,0.496,1147,0.77,"meloxicam, amfenac, FR.122047, aspirin, phenazone, curcumin, ramifenazone, indoprofen, suxibuzone, acetylsalicylsalicylic.acid",0.304518323509803,0.113509274827518,FALSE +"H460","Pearson.est","cytochrome P450 inhibitor",0.37629,0.978,0.465,336,0.894,"metyrapone, itraconazole, morin",0.332547047110046,0.0486624812040823,FALSE +"H460","Pearson.est","DNA alkylating agent",-0.34644,-0.872,0.605,1105,0.753,"melphalan, dianhydrogalactitol, mitomycin.c, carboplatin, TH.302",0.218244625347531,0.123205023799299,FALSE +"H460","Pearson.est","DNA inhibitor",-0.53032,-1.36,0.156,1105,0.724,"melphalan, nithiamide, sangivamycin, valrubicin, carboplatin, teroxirone",0.806875401645538,0.140261433802853,FALSE +"H460","Pearson.est","DNA methyltransferase inhibitor",-0.48627,-1.27,0.215,1318,0.893,"azacitidine, decitabine",0.667561540084395,0.0491485411114536,FALSE +"H460","Pearson.est","DNA polymerase inhibitor",0.64065,1.69,0.0285,199,0.484,"cidofovir, adefovir.dipivoxil, menadione, famciclovir",1.54515513999149,0.315154638355588,FALSE +"H460","Pearson.est","DNA synthesis inhibitor",-0.46508,-1.19,0.262,1142,0.956,"anisomycin, CB.10.277, mitomycin.c, altretamine, cyclocytidine, floxuridine",0.581698708680255,0.0195421077238999,FALSE +"H460","Pearson.est","dopamine receptor antagonist",0.39649,1.07,0.345,175,0.934,"nemonapride, remoxipride, lurasidone, mesoridazine, clebopride",0.462180904926726,0.0296531237699066,FALSE +"H460","Pearson.est","estrogen receptor agonist",0.19759,0.518,0.964,361,1,"erteberel, ethinyl.estradiol",0.0159229660971692,0,FALSE +"H460","Pearson.est","estrogen receptor antagonist",0.6005,1.62,0.0458,11,0.52,"tamoxifen",1.33913452199613,0.283996656365201,FALSE +"H460","Pearson.est","FGFR inhibitor",0.38891,1.02,0.415,392,0.941,"erdafitinib, orantinib, nintedanib, lenvatinib, lucitanib",0.381951903287907,0.0264103765727431,FALSE +"H460","Pearson.est","FLT3 inhibitor",0.25235,0.664,0.865,263,1,"GTP.14564, TG.02, sorafenib, TG.101348, midostaurin",0.0629838925351858,0,FALSE +"H460","Pearson.est","glucocorticoid receptor agonist",0.54698,1.44,0.114,411,0.74,"hydrocortisone, piretanide, triamcinolone, halcinonide, triamcinolone.acetonide, difluprednate, deflazacort, dexamethasone.acetate, beclomethasone.dipropionate, flumethasone.pivalate, prednisolone.hemisuccinate, betamethasone",0.943095148663527,0.130768280269024,FALSE +"H460","Pearson.est","glutamate receptor antagonist",0.25971,0.687,0.832,430,1,"LY456236, kynurenic.acid, JNJ.16259685, IEM1754, CPP",0.0798766737092761,0,FALSE +"H460","Pearson.est","glycogen synthase kinase inhibitor",-0.30809,-0.789,0.717,980,0.776,"AZD2858, tideglusib, kenpaullone, LY2090314",0.1444808443322,0.110138278741812,FALSE +"H460","Pearson.est","growth factor receptor inhibitor",-0.71854,-1.8,0.0123,1117,0.214,"danusertib, lestaurtinib, AZD3463, GSK1838705A, PHA.848125, GW.441756",1.9100948885606,0.669586226650809,TRUE +"H460","Pearson.est","HCV inhibitor",-0.3528,-0.926,0.523,1081,0.776,"Ro.9187, daclatasvir",0.281498311132726,0.110138278741812,FALSE +"H460","Pearson.est","HDAC inhibitor",-0.40426,-1.05,0.377,1017,0.774,"M.344, dacinostat, JNJ.26481585, AR.42, romidepsin, PCI.24781, panobinostat, entinostat, givinostat, R306465, tacedinaline, chidamide",0.423658649794207,0.111259039317107,FALSE +"H460","Pearson.est","histamine receptor antagonist",-0.25437,-0.654,0.883,1128,0.87,"levocetirizine, pheniramine, astemizole, ranitidine, terfenadine, zolantidine",0.0540392964224314,0.0604807473813815,FALSE +"H460","Pearson.est","HMGCR inhibitor",0.32412,0.861,0.619,261,0.945,"lovastatin, atorvastatin",0.208309350979882,0.0245681914907371,FALSE +"H460","Pearson.est","HSP inhibitor",-0.42422,-1.11,0.309,927,0.852,"tanespimycin, XL888, VER.49009, NMS.E973, ganetespib, NVP.AUY922, SNX.2112, BIIB021, PU.H71, SNX.5422",0.510041520575165,0.0695604052332999,FALSE +"H460","Pearson.est","JAK inhibitor",0.17339,0.465,0.985,523,1,"TG.02, TG.101348, TG.101209, AT.9283, LY2784544, AZD1480, atiprimod, filgotinib, CEP.33779",0.00656376950238827,0,FALSE +"H460","Pearson.est","KIT inhibitor",0.32605,0.847,0.62,333,0.937,"cediranib, telatinib, sorafenib, midostaurin, lenvatinib, motesanib",0.207608310501746,0.0282604091122217,FALSE +"H460","Pearson.est","MDM inhibitor",-0.71116,-1.83,0.00749,1266,0.26,"CGM097, serdemetan, idasanutlin, nutlin.3",2.12551818230053,0.585026652029182,FALSE +"H460","Pearson.est","MEK inhibitor",-0.58352,-1.52,0.0669,1057,0.477,"nobiletin, arctigenin, selumetinib, AZD8330, PD.198306, TAK.733, cobimetinib, MEK162, refametinib, PD.98059, PD.184352, AS.703026, Ro.4987655, PD.0325901, trametinib",1.17457388223218,0.321481620959886,FALSE +"H460","Pearson.est","MET inhibitor",-0.34951,-0.9,0.553,504,0.774,"AMG458, LY2801653, NVP.BVU972, INC.280, PHA.665752, PF.04217903",0.257274868695302,0.111259039317107,FALSE +"H460","Pearson.est","microtubule inhibitor",0.31506,0.808,0.669,213,0.911,"triclabendazole, cytochalasin.b, colchicine",0.174573882232177,0.0404816230270017,FALSE +"H460","Pearson.est","mTOR inhibitor",-0.43514,-1.1,0.34,1225,0.783,"AZD2014, MLN0128, sirolimus, NVP.BEZ235, PI.103, ku.0063794, LY303511, PP242",0.468521082957745,0.106238237942057,FALSE +"H460","Pearson.est","NFkB pathway inhibitor",0.43332,1.13,0.292,245,0.845,"tyloxapol, parthenolide, IKK.2.inhibitor.V",0.534617148551582,0.0731432910503077,FALSE +"H460","Pearson.est","opioid receptor agonist",-0.27484,-0.717,0.813,1008,0.835,"salvinorin.a, spiradoline, BW.180C",0.0899094544059319,0.0783135245163979,FALSE +"H460","Pearson.est","p38 MAPK inhibitor",-0.42168,-1.08,0.355,1193,0.786,"CMPD.1, VX.702",0.449771646944906,0.104577453960592,FALSE +"H460","Pearson.est","PARP inhibitor",-0.68161,-1.73,0.0235,1348,0.261,"niraparib, talazoparib, olaparib",1.62893213772826,0.583359492661719,FALSE +"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.27761,0.728,0.779,333,0.981,"linifanib, orantinib, telatinib, nintedanib, sorafenib, lenvatinib, motesanib",0.108462542327436,0.0083309926200515,FALSE +"H460","Pearson.est","phosphatase inhibitor",0.33263,0.875,0.59,196,0.996,"GSK2830371, menadione, BVT.948",0.229147988357856,0.00174066157630127,FALSE +"H460","Pearson.est","phosphodiesterase inhibitor",-0.45,-1.17,0.284,1070,0.937,"zardaverine, cilostamide, papaverine, EMD.53998, GSK256066, YM.976, trequinsin",0.546681659952962,0.0282604091122217,FALSE +"H460","Pearson.est","PI3K inhibitor",-0.2647,-0.675,0.836,1337,0.867,"NVP.BEZ235, PIK.75, PI.103, LY303511",0.0777937225609836,0.0619809025237897,FALSE +"H460","Pearson.est","PLK inhibitor",-0.62322,-1.59,0.068,1073,0.398,"GW.843682X, NMS.1286937, BI.2536, HMN.214, GSK461364",1.16749108729376,0.400116927926312,FALSE +"H460","Pearson.est","potassium channel blocker",-0.33683,-0.867,0.615,1297,0.74,"oleoylethanolamide, meglitinide",0.211124884224583,0.130768280269024,FALSE +"H460","Pearson.est","PPAR receptor agonist",0.57444,1.52,0.0744,210,0.652,"GW.501516, fenofibrate, pterostilbene, S26948",1.12842706445412,0.18575240426808,FALSE +"H460","Pearson.est","progesterone receptor agonist",0.48928,1.32,0.174,456,0.742,"norgestrel, norethindrone, melengestrol.acetate, tanaproget, nomegestrol.acetate",0.7594507517174,0.129596094720973,FALSE +"H460","Pearson.est","proteasome inhibitor",0.18125,0.465,0.99,1187,1,"carfilzomib, oprozomib, ONX.0914, bortezomib, ixazomib.citrate, MG.132, ixazomib, delanzomib",0.00436480540245009,0,FALSE +"H460","Pearson.est","protein synthesis inhibitor",-0.39369,-0.987,0.491,1059,0.742,"homoharringtonine, azomycin..2.nitroimidazole., chloramphenicol.palmitate, emetine, cycloheximide, thiostrepton, brefeldin.a",0.308918507877032,0.129596094720973,FALSE +"H460","Pearson.est","protein tyrosine kinase inhibitor",0.39404,1.06,0.344,574,0.9,"CP.724714, rheochrysidin, PP.121, mubritinib, AV.412",0.46344155742847,0.0457574905606751,FALSE +"H460","Pearson.est","RAF inhibitor",-0.32537,-0.841,0.611,975,0.759,"AZ.628, dabrafenib, CEP.32496, RAF265, regorafenib, vemurafenib, SB.590885, LGX818",0.213958789757446,0.11975822410452,FALSE +"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.34205,-0.876,0.594,990,0.768,"sunitinib, cabozantinib, regorafenib",0.226213555018806,0.114638779968488,FALSE +"H460","Pearson.est","retinoid receptor agonist",0.31141,0.819,0.7,14,0.922,"fenretinide",0.154901959985743,0.0352690789463706,FALSE +"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.56772,-1.45,0.087,1239,0.572,"hydroxyurea, clofarabine, cladribine, fludarabine, fludarabine.phosphate",1.06048074738138,0.242603971206976,FALSE +"H460","Pearson.est","serotonin receptor agonist",-0.3873,-0.989,0.442,1447,0.766,"aripiprazole",0.354577730650908,0.115771230367396,FALSE +"H460","Pearson.est","serotonin receptor antagonist",-0.35302,-0.893,0.568,1061,0.762,"RS.16566, SB.216641, SB.228357, ziprasidone, SB.200646, aripiprazole",0.245651664288981,0.1180450286604,FALSE +"H460","Pearson.est","sodium channel blocker",0.21036,0.575,0.946,360,1,"cibenzoline, benzethonium, lappaconite, mepivacaine",0.0241088635982073,0,FALSE +"H460","Pearson.est","src inhibitor",0.49438,1.3,0.193,71,0.711,"ZM.306416, PP.1",0.714442690992226,0.148130399270234,FALSE +"H460","Pearson.est","sterol demethylase inhibitor",-0.39597,-1.01,0.43,1296,0.755,"ketoconazole, lanoconazole",0.366531544420413,0.122053048370812,FALSE +"H460","Pearson.est","TGF beta receptor inhibitor",0.85937,2.27,0,123,0.00516,"adaprev, SB.525334, SB.431542, repsox",Inf,2.28735029837279,TRUE +"H460","Pearson.est","thymidylate synthase inhibitor",-0.73562,-1.85,0.00549,1382,0.432,"carmofur, raltitrexed",2.26042765554991,0.364516253185088,FALSE +"H460","Pearson.est","topoisomerase inhibitor",-0.62289,-1.64,0.038,1123,0.361,"beta.lapachone, etoposide, idarubicin, irinotecan, topotecan, voreloxin, SN.38, TAS.103, nemorubicin, valrubicin, rubitecan, camptothecin, amonafide, exatecan.mesylate, mitoxantrone, amsacrine, genz.644282",1.42021640338319,0.442492798094342,FALSE +"H460","Pearson.est","tubulin polymerization inhibitor",-0.48443,-1.25,0.212,1068,0.865,"vinblastine, oxibendazole, ABT.751, podophyllotoxin, fosbretabulin, epothilone.b, verubulin, KX2.391, taltobulin, combretastatin.A.4, mebendazole, BNC105",0.673664139071249,0.0629838925351858,FALSE +"H460","Pearson.est","tyrosine kinase inhibitor",0.13953,0.371,1,340,0.999,"GTP.14564, sorafenib, CP.724714, UNC2250, rheochrysidin",0,0.000434511774017692,FALSE +"H460","Pearson.est","VEGFR inhibitor",0.3571,0.952,0.502,392,0.91,"ZM.306416, cediranib, linifanib, orantinib, telatinib, nintedanib, sorafenib, BMS.690514, lenvatinib, semaxanib, motesanib, golvatinib, lucitanib",0.299296282854981,0.0409586076789064,FALSE +"H460","Pearson.est","vitamin D receptor agonist",0.29641,0.783,0.696,157,0.922,"alfacalcidol, paricalcitol",0.157390760389438,0.0352690789463706,FALSE +"H520","Pearson.est","EGFR inhibitor",0.27517,0.704,0.818,418,0.938,"WZ.3146, vandetanib, WZ8040, CNX.2006, pelitinib, CGP.52411, icotinib, canertinib, AST.1306, BMS.690514, afatinib, rociletinib, tyrphostin.AG.494, BIBU.1361, erlotinib, PD.168393, dacomitinib, poziotinib, BIBX.1382",0.087246696328677,0.0277971616209356,FALSE +"H520","Pearson.est","Abl kinase inhibitor",0.49309,1.28,0.197,230,0.615,"flumatinib, KW.2449, ZM.306416, dasatinib",0.705533773838407,0.211124884224583,FALSE +"H520","Pearson.est","acetylcholine receptor agonist",0.31363,0.818,0.663,494,0.948,"xanomeline, nefiracetam, nicotine",0.178486471595227,0.0231916626619338,FALSE +"H520","Pearson.est","acetylcholine receptor antagonist",-0.33074,-0.894,0.543,1403,0.705,"diphemanil",0.265200170411153,0.151810883008601,FALSE +"H520","Pearson.est","adenosine receptor antagonist",0.57047,1.45,0.109,491,0.582,"theophylline, MRS.1220, sulmazole, istradefylline, CGS.15943",0.962573502059376,0.235077015350112,FALSE +"H520","Pearson.est","adrenergic receptor agonist",0.49369,1.26,0.211,243,0.574,"oxymetazoline, norepinephrine, terbutaline, midodrine, buphenine, A61603, clenbuterol",0.675717544702307,0.241088107602027,FALSE +"H520","Pearson.est","adrenergic receptor antagonist",-0.31245,-0.814,0.666,1303,0.81,"naftidrofuryl, prazosin, idazoxan, vincamine",0.176525770829699,0.0915149811213502,FALSE +"H520","Pearson.est","AKT inhibitor",0.4088,1.06,0.397,192,0.69,"AT7867, palomid.529, CCT128930, MK.2206",0.401209493236885,0.161150909262745,FALSE +"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.39632,-1.04,0.379,1275,0.728,"AZD3463, CEP.37440, crizotinib",0.421360790031928,0.137868620686963,FALSE +"H520","Pearson.est","androgen receptor antagonist",0.4801,1.21,0.232,253,0.633,"bicalutamide, RU.58841",0.6345120151091,0.198596289982645,FALSE +"H520","Pearson.est","antioxidant",0.41932,1.06,0.362,15,0.69,"benfotiamine",0.441291429466834,0.161150909262745,FALSE +"H520","Pearson.est","AP inhibitor",0.43649,1.12,0.319,519,0.702,"birinapant, embelin, GDC.0152",0.496209316942819,0.153662887870195,FALSE +"H520","Pearson.est","ATPase inhibitor",-0.44172,-1.17,0.269,1260,0.594,"omeprazole, NMS.873, digitoxigenin, rabeprazole, digoxin",0.570247719997592,0.226213555018806,FALSE +"H520","Pearson.est","Aurora kinase inhibitor",0.18436,0.473,0.974,469,0.986,"KW.2449, CYC116, ZM.447439, hesperadin, GSK1070916, MLN.8054, SNS.314, CCT129202, alisertib",0.0114410431213845,0.0061230850587888,FALSE +"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.39851,-1.05,0.387,1039,0.745,"radezolid, tedizolid, dirithromycin, azithromycin, azalomycin.b",0.412289034981089,0.127843727251707,FALSE +"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.62164,1.56,0.0659,352,0.561,"trovafloxacin, novobiocin, sparfloxacin, nadifloxacin, finafloxacin",1.18111458540599,0.251037138743839,FALSE +"H520","Pearson.est","BCL inhibitor",0.46703,1.2,0.257,608,0.618,"ABT.737, TW.37, HA14.1, navitoclax, gossypol, obatoclax, oridonin",0.590066876668705,0.209011524911184,FALSE +"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.30858,0.779,0.712,230,0.927,"flumatinib, dasatinib",0.147520006363144,0.0329202658555029,FALSE +"H520","Pearson.est","benzodiazepine receptor agonist",0.52092,1.33,0.152,374,0.73,"lorazepam, temazepam, CGS.20625, gamma.aminobutyric.acid, indiplon, nefiracetam",0.818156412055227,0.136677139879544,FALSE +"H520","Pearson.est","bromodomain inhibitor",0.27184,0.701,0.805,1056,0.918,"bromosporine, I.BET151, PFI.1, OTX015, I.BET.762, JQ1....",0.0942041196321315,0.0371573187987575,FALSE +"H520","Pearson.est","calcium channel blocker",0.2329,0.612,0.909,56,0.93,"efonidipine.monoethanolate",0.0414361167780325,0.0315170514460649,FALSE +"H520","Pearson.est","CC chemokine receptor antagonist",-0.35154,-0.937,0.527,1011,0.683,"UNBS.5162, navarixin, SB.225002, PF.04136309, ZK811752",0.278189384787453,0.165579296318467,FALSE +"H520","Pearson.est","CDK inhibitor",-0.54737,-1.43,0.11,1016,0.417,"AT.7519, indisulam, ribociclib, PHA.793887, dinaciclib, JNJ.7706621, alvocidib, abemaciclib, arcyriaflavin.a, NU6027, AZD5438, BMS.265246, BMS.387032, PHA.848125",0.958607314841775,0.379863945026242,FALSE +"H520","Pearson.est","CHK inhibitor",0.36397,0.957,0.489,43,0.836,"AZD7762",0.31069114087638,0.0777937225609836,FALSE +"H520","Pearson.est","cyclooxygenase inhibitor",0.26133,0.649,0.877,247,0.936,"ketoprofen, metoxibutropate, piroxicam, indoprofen, tryptanthrin",0.0570004066339595,0.0287241512618947,FALSE +"H520","Pearson.est","cytochrome P450 inhibitor",0.67597,1.7,0.0276,186,0.429,"itraconazole, cobicistat, eplerenone",1.55909091793478,0.367542707815276,FALSE +"H520","Pearson.est","DNA alkylating agent",-0.38903,-1.03,0.384,1067,0.711,"temozolomide, satraplatin, cyclophosphamide, melphalan, dacarbazine, mitomycin.c",0.415668775632469,0.148130399270234,FALSE +"H520","Pearson.est","DNA inhibitor",-0.59418,-1.57,0.0719,1216,0.444,"busulfan, melphalan, nimorazole, bendamustine, teroxirone, sangivamycin, metronidazole",1.14327110961712,0.35261702988538,FALSE +"H520","Pearson.est","DNA methyltransferase inhibitor",-0.37274,-0.983,0.441,1154,0.768,"azacitidine, SGI.1027, fdcyd, decitabine",0.355561410532161,0.114638779968488,FALSE +"H520","Pearson.est","DNA polymerase inhibitor",0.55304,1.46,0.0993,325,0.64,"cephalomannine, menadione, cidofovir, famciclovir",1.00305075150462,0.193820026016113,FALSE +"H520","Pearson.est","DNA synthesis inhibitor",-0.36911,-0.975,0.47,1222,0.751,"cyclocytidine, floxuridine, enocitabine, nelarabine, mitomycin.c",0.327902142064283,0.124360062995832,FALSE +"H520","Pearson.est","dopamine receptor antagonist",0.42886,1.1,0.341,224,0.674,"nemonapride, UH.232...., acetophenazine, clebopride, raclopride, lurasidone",0.467245621007502,0.17134010346468,FALSE +"H520","Pearson.est","estrogen receptor agonist",0.31639,0.792,0.674,36,0.963,"PPT",0.17134010346468,0.0163737128754655,FALSE +"H520","Pearson.est","estrogen receptor antagonist",-0.57345,-1.49,0.0839,1025,0.409,"tamoxifen, toremifene, raloxifene",1.0762380391713,0.388276691992658,FALSE +"H520","Pearson.est","FGFR inhibitor",-0.51548,-1.36,0.138,1263,0.448,"nintedanib, dovitinib, lenvatinib, regorafenib",0.860120913598763,0.348721986001856,FALSE +"H520","Pearson.est","FLT3 inhibitor",-0.35827,-0.946,0.496,1179,0.692,"ENMD.2076, sorafenib, lestaurtinib, pacritinib, tyrphostin.AG.1296, dovitinib, TG.101348",0.304518323509803,0.159893905543242,FALSE +"H520","Pearson.est","glucocorticoid receptor agonist",0.36701,0.952,0.508,404,0.814,"piretanide, hydrocortisone, deflazacort, prednisolone.hemisuccinate, flumethasone.pivalate, triamcinolone, clobetasol.propionate, fludroxycortide, prednisolone",0.294136287716081,0.0893755951107988,FALSE +"H520","Pearson.est","glutamate receptor antagonist",0.50061,1.3,0.187,227,0.734,"SIB.1757, JNJ.16259685, latrepirdine, kynurenic.acid, LY456236",0.728158393463501,0.134303940083929,FALSE +"H520","Pearson.est","glycogen synthase kinase inhibitor",0.50873,1.28,0.194,583,0.615,"LY2090314, indirubin, CHIR.99021, CHIR.98014, TWS.119, GSK.3.inhibitor.IX",0.712198270069774,0.211124884224583,FALSE +"H520","Pearson.est","growth factor receptor inhibitor",-0.68015,-1.73,0.0364,1257,0.242,"lestaurtinib, AZD3463, GW.441756, PHA.848125, danusertib",1.43889861635094,0.616184634019569,TRUE +"H520","Pearson.est","HCV inhibitor",0.45279,1.15,0.297,71,0.678,"Ro.9187",0.527243550682788,0.168770306132937,FALSE +"H520","Pearson.est","HDAC inhibitor",0.25877,0.663,0.878,336,0.943,"romidepsin, RG2833, RGFP966, pyroxamide, belinostat, nexturastat.a, mocetinostat, JNJ.26481585",0.0565054840938974,0.0254883072626717,FALSE +"H520","Pearson.est","histamine receptor antagonist",0.61981,1.56,0.0658,254,0.561,"chloropyramine, epinastine, BF2.649, famotidine, ICI.162846, terfenadine, tiotidine, pheniramine, lafutidine",1.18177410638604,0.251037138743839,FALSE +"H520","Pearson.est","HMGCR inhibitor",0.71945,1.85,0.0057,391,0.488,"pitavastatin, atorvastatin, fluvastatin, mevastatin, lovastatin",2.24412514432751,0.311580177997289,FALSE +"H520","Pearson.est","HSP inhibitor",0.27805,0.724,0.776,129,0.96,"KW.2478, VER.49009",0.110138278741812,0.0177287669604316,FALSE +"H520","Pearson.est","JAK inhibitor",-0.48403,-1.26,0.212,1257,0.509,"lestaurtinib, LY2784544, pacritinib, baricitinib, TG.101348",0.673664139071249,0.293282217663241,FALSE +"H520","Pearson.est","KIT inhibitor",-0.2872,-0.749,0.741,1192,0.886,"sorafenib, OSI.930, pazopanib, lenvatinib, regorafenib",0.130181792020672,0.0525662781129492,FALSE +"H520","Pearson.est","MDM inhibitor",-0.22047,-0.583,0.924,1169,0.934,"nutlin.3, idasanutlin",0.0343280287798933,0.0296531237699066,FALSE +"H520","Pearson.est","MEK inhibitor",0.37734,0.972,0.479,468,0.837,"U.0126, PD.184352, TAK.733, BIX.02188, arctigenin, PD.98059, refametinib, MEK1.2.inhibitor, PD.318088, AZD8330",0.319664486585437,0.07727454200674,FALSE +"H520","Pearson.est","MET inhibitor",-0.26214,-0.7,0.793,378,0.856,"LY2801653, AMG458, NVP.BVU972, PF.04217903, PHA.665752, INC.280",0.100726812682396,0.0675262353228468,FALSE +"H520","Pearson.est","microtubule inhibitor",-0.36534,-0.958,0.492,955,0.753,"secnidazole, cabazitaxel, colchicine, vinblastine, podophyllotoxin, vinflunine, D.64131",0.30803489723264,0.123205023799299,FALSE +"H520","Pearson.est","mTOR inhibitor",-0.51302,-1.34,0.164,1038,0.446,"PKI.179, WAY.600, PF.04691502, sirolimus, GSK2126458, OSI.027, XL388, voxtalisib, WYE.354, NVP.BEZ235, WYE.125132, PP242, ku.0063794, AZD8055, MLN0128, AZD2014",0.785156151952302,0.350665141287858,FALSE +"H520","Pearson.est","NFkB pathway inhibitor",0.27931,0.728,0.79,305,0.981,"BAY.11.7085, IKK.2.inhibitor.V, tyloxapol",0.102372908709559,0.0083309926200515,FALSE +"H520","Pearson.est","opioid receptor agonist",0.57142,1.48,0.0904,4,0.686,"cebranopadol",1.04383156952464,0.163675884293248,FALSE +"H520","Pearson.est","p38 MAPK inhibitor",-0.66,-1.73,0.033,1447,0.242,"talmapimod",1.48148606012211,0.616184634019569,TRUE +"H520","Pearson.est","PARP inhibitor",-0.35235,-0.914,0.519,1148,0.696,"niraparib, olaparib, PJ.34",0.284832642151542,0.157390760389438,FALSE +"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.26266,-0.702,0.797,1192,0.877,"sorafenib, crenolanib, pazopanib, nintedanib, dovitinib, lenvatinib, regorafenib",0.0985416786038876,0.0570004066339595,FALSE +"H520","Pearson.est","phosphatase inhibitor",0.27437,0.717,0.793,338,0.945,"menadione, mycophenolate.mofetil, CID.5458317",0.100726812682396,0.0245681914907371,FALSE +"H520","Pearson.est","phosphodiesterase inhibitor",0.56915,1.44,0.11,487,0.539,"papaverine, anagrelide, avanafil, GSK256066, YM.976, enoximone, EMD.53998",0.958607314841775,0.268411234813261,FALSE +"H520","Pearson.est","PI3K inhibitor",-0.36408,-0.947,0.492,1128,0.716,"PIK.75, GSK2126458, alpelisib, voxtalisib, CUDC.907, NVP.BEZ235, PI3K.IN.2, YM.201636, idelalisib, CH5132799",0.30803489723264,0.145086977692144,FALSE +"H520","Pearson.est","PLK inhibitor",-0.81935,-2.16,0,1262,0.0304,"GSK461364, HMN.214, volasertib, BI.2536, GW.843682X, NMS.1286937",Inf,1.51712641639125,TRUE +"H520","Pearson.est","potassium channel blocker",0.32672,0.839,0.66,522,0.94,"meglitinide, dofetilide, ibutilide, mepivacaine",0.180456064458131,0.0268721464003014,FALSE +"H520","Pearson.est","PPAR receptor agonist",0.49267,1.26,0.209,237,0.574,"S26948, fenofibrate",0.679853713888946,0.241088107602027,FALSE +"H520","Pearson.est","progesterone receptor agonist",0.3317,0.845,0.629,287,0.96,"norgestrel, tanaproget, norethindrone",0.201349354554731,0.0177287669604316,FALSE +"H520","Pearson.est","proteasome inhibitor",-0.22847,-0.606,0.931,329,0.939,"ixazomib.citrate, ONX.0914, oprozomib, bortezomib, carfilzomib, ixazomib, MG.132, delanzomib",0.0310503190186574,0.0273344077338891,FALSE +"H520","Pearson.est","protein synthesis inhibitor",-0.56568,-1.48,0.0987,1231,0.383,"emetine, clofoctol, anguidine, tedizolid.phosphate, harringtonine, bruceantin, homoharringtonine, chloramphenicol.palmitate",1.00568284733036,0.416801226031377,FALSE +"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.27014,-0.708,0.812,1151,0.92,"BMS.599626, mubritinib, tyrphostin.A9",0.0904439707588247,0.0362121726544447,FALSE +"H520","Pearson.est","RAF inhibitor",-0.56474,-1.54,0.0901,1060,0.377,"TAK.632, vemurafenib, sorafenib, SB.590885, RAF265, LGX818, AZ.628, regorafenib",1.04527520902094,0.423658649794207,FALSE +"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.42452,-1.14,0.297,1192,0.614,"sorafenib, regorafenib",0.527243550682788,0.211831628858832,FALSE +"H520","Pearson.est","retinoid receptor agonist",-0.49849,-1.31,0.188,1004,0.458,"CD.437, bexarotene, adapalene, tamibarotene, adarotene, AM.580",0.72584215073632,0.339134521996131,FALSE +"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.36279,-0.949,0.511,1187,0.74,"hydroxyurea, fludarabine.phosphate, pentostatin",0.291579099865287,0.130768280269024,FALSE +"H520","Pearson.est","serotonin receptor agonist",0.66534,1.71,0.0229,1,0.601,"aripiprazole",1.64016451766011,0.22112552799726,FALSE +"H520","Pearson.est","serotonin receptor antagonist",0.5068,1.29,0.198,224,0.695,"aripiprazole, RS.16566, lerisetron, tropisetron, lurasidone",0.703334809738469,0.158015195409886,FALSE +"H520","Pearson.est","sodium channel blocker",0.30496,0.783,0.717,332,0.948,"quinidine, lappaconite, ajmaline, A.803467, benzethonium",0.1444808443322,0.0231916626619338,FALSE +"H520","Pearson.est","src inhibitor",0.35015,0.912,0.545,230,0.861,"PP.2, ZM.306416, dasatinib",0.263603497723358,0.0649968485463452,FALSE +"H520","Pearson.est","sterol demethylase inhibitor",-0.68719,-1.85,0.0104,1407,0.285,"chlormidazole, ketoconazole, lanoconazole",1.98296666070122,0.54515513999149,FALSE +"H520","Pearson.est","TGF beta receptor inhibitor",0.425,1.1,0.323,644,0.674,"D.4476, SB.431542, repsox, LY2109761",0.490797477668897,0.17134010346468,FALSE +"H520","Pearson.est","thymidylate synthase inhibitor",-0.63628,-1.73,0.0277,1086,0.242,"raltitrexed, trifluridine, carmofur, ftorafur",1.55752023093555,0.616184634019569,TRUE +"H520","Pearson.est","topoisomerase inhibitor",-0.45754,-1.18,0.263,1199,0.611,"amsacrine, camptothecin, genz.644282, nemorubicin, etoposide.phosphate, topotecan, mitoxantrone, dexrazoxane, SN.38",0.580044251510242,0.213958789757446,FALSE +"H520","Pearson.est","tubulin polymerization inhibitor",-0.53365,-1.41,0.123,911,0.41,"docetaxel, vindesine, vinorelbine, paclitaxel, dolastatin.10, vincristine, epothilone.b, vinblastine, combretastatin.A.4, fenbendazole, CYT.997, oxibendazole, verubulin, podophyllotoxin, plinabulin, ABT.751, BNC105, taltobulin, KX2.391, mebendazole",0.910094888560602,0.387216143280265,FALSE +"H520","Pearson.est","tyrosine kinase inhibitor",-0.27742,-0.707,0.791,1143,0.895,"tyrphostin.AG.99, BMS.599626, mubritinib, tyrphostin.A9, sorafenib, bafetinib, tivantinib, regorafenib",0.101823516502323,0.048176964684088,FALSE +"H520","Pearson.est","VEGFR inhibitor",0.24159,0.618,0.91,365,0.947,"orantinib, SU014813, vatalanib, ZM.306416, semaxanib, vandetanib, motesanib, MK.2461, MGCD.265, BMS.690514, cediranib, axitinib, KI.8751, SAR131675",0.0409586076789064,0.0236500209967266,FALSE +"H520","Pearson.est","vitamin D receptor agonist",-0.58618,-1.54,0.0862,1248,0.377,"calcitriol, maxacalcitol, doxercalciferol",1.06449273417529,0.423658649794207,FALSE diff --git a/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_venn_diagram.pdf b/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_venn_diagram.pdf new file mode 100644 index 0000000000000000000000000000000000000000..26a482c44836b9105f1dff1889e5059698c6b01d GIT binary patch literal 7591 zcmZ{pc|4SR`^PPzhU}7vp{!wMjAh8aXWz*_jlpCYX2x1}A~aISzGMr@mK2d)$dX+N zA+lv>to=skbk2F6^Ly^U=KHy??R(vS%=La3I++sq0sKCa2ygSpeiE<783_UAW~vr2`B_62mtA#9scJ#6BN#s=w$@d zz`#A6Q3xzh-wWsAg(JEdV9*X;2qfn8t+*&u6hhQ~Qe=H3sR9`_mkxf_BFdk60k=mpjM^ ziA8&15X5-m{}u1l;CDN8knT=6XCPD@ECB?mqg-*s8-UbZiOo?(BG3-V)4H)ZV$a+F zzUix0x@9&R3=>m!o|2lK^A5Fz3oh)`p*$hXuJ_fNh3E~KHON4OLle`!im57L-ZjSv z94q8U`gN$>vElF+l@-E4`E1ARR1I4G2%Auqko#ir^T+ONdbwVUj-V6IqaDKjZku^o z{e#)8HFvwWhu!9OoKx@WJa0&E>JMhEHT>M4M`X6(Z+o}PPENipT=D({3#|1^b80no 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zKMa2juS`rR30mEDaBh!6ou{EK~x8bOpEHgAb;9~&zm`y@OaxbXs z2wkh5nOCvY6!?~Zgo7{g)q)A zwxFbgwcRF#Fu%7YQ56A>2NrJRm6=&|%jVPIp%49BYf&p~ayPvzs#~*j=lnVe`|Ja< zh6r<<_t@pe*BNwaS_^5(avwaGmzL%S?64ZXgyh$WlCfB4N|p4V4L|-cV1zAB#W1+9 z^|zfw|60)*flaH`+`_hF4i^oN3h~tlXwRexf-#_aKD8ekew?_^94K~LYO%~AE4M5w zysLGqRd-Y4qAF$uXX@_c{HkAKXM zc{O;ShzQZki2pX#Eu3aq&O!F=?h6Rjnb z68Pjl1}+}n*x6jqeWRTgNV5N8`}lu_}n4*0bj1*FenGe77ihH1V-A}*#Qin z0%Y$DEQN4JaDW7%Fr+=ifdd3T6VeW#2d=I*|JLs033arAd%C&Wcmlyc%n`^DxB#o! zoXw0NrV=dvEmA)t0{=wfe`(;1Cj3v5g4hV~5G@-wKqP=VoayDSK57tG6a?vPXF~z{ zM=u;_D*gBKTi$Sp1BDQWun2|FzkVDN;^Ly>91a}+Y7+qn3Gv4P{a2f?1i+U5qfJ;y zLL6X7|J5cb2E4`pYLk)zj(Po88~FcNLqr%jkM + + + +visNetwork + + + + + + + +
+
+
+ + + + diff --git a/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_mean_results.csv b/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_mean_results.csv new file mode 100644 index 0000000..975f4d9 --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_mean_results.csv @@ -0,0 +1,84 @@ +"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p" +"TGF beta receptor inhibitor",0.913333333333333,1.00986410726964,0.00295420917678714,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC15",0.0204332801394444 +"opioid receptor agonist",0.821833333333333,1.29748461776367,3.18461727594471e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1650, H520, HCC15",0.000528646467806823 +"p38 MAPK inhibitor",0.770416666666667,0.865615016078514,0.204841463769956,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.472273374802954 +"serotonin receptor antagonist",0.660333333333333,1.09067846552112,0.0474600935910376,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.164132823669005 +"DNA methyltransferase inhibitor",0.650166666666667,1.20612805240069,0.00793405531467982,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.0439017727412283 +"acetylcholine receptor agonist",0.638416666666667,1.2013921060271,0.00332866118057934,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1650, HCC95, H1648",0.0212522213836988 +"cytochrome P450 inhibitor",0.624916666666667,1.2004672922229,0.0773388332553046,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.246889352315011 +"FGFR inhibitor",0.61975,1.19126801236024,0.0124836168362864,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0609494233771628 +"DNA polymerase inhibitor",0.615916666666667,0.969000746630103,0.289899084157724,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602943525907879 +"serotonin receptor agonist",0.549,1.63596692441436,0.000342986783840368,"H1650, H1975, H1648, H2126, H520, H1299, HCC44, A549, H1703, HCC15",10,5,"H1650, H1975, H2126, H520, HCC44",0.00355848788234381 +"RET tyrosine kinase inhibitor",0.454416666666667,1.11954101458291,0.15853229885422,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.395508587605083 +"MEK inhibitor",0.424916666666667,1.52881471963404,0.000168928610080343,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H520, HCC44",0.00200301066238121 +"ALK tyrosine kinase receptor inhibitor",0.4175,0.979026835921542,0.59787788919107,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.842195416188551 +"NFkB pathway inhibitor",0.412833333333333,0.935240157133531,0.701908331500717,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.910287367414993 +"dopamine receptor antagonist",0.3865,0.952093721513515,0.720138394834125,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.919561334942037 +"proteasome inhibitor",0.365166666666667,1.0829952432812,0.244445707548859,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.53392088754093 +"HSP inhibitor",0.345083333333333,1.37469411198097,0.000816485868795425,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1650, HCC95",0.00752981412333559 +"bromodomain inhibitor",0.322333333333333,1.30509549168796,0.00469301275409585,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.027822861327854 +"FLT3 inhibitor",0.320166666666667,1.00432617241913,0.67272001519146,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.900576794530503 +"potassium channel blocker",0.3155,1.16333912041627,0.145405949708937,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H2126",0.380342911769697 +"ATPase inhibitor",0.314166666666667,1.18801613344825,0.117507434219084,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.325103901339466 +"sodium channel blocker",0.29275,0.848811696110831,0.966336603040099,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476 +"bacterial DNA gyrase inhibitor",0.290166666666667,1.17881302652929,0.0943927860836075,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.281356632742163 +"RAF inhibitor",0.280166666666667,1.11642553253541,0.319709981358538,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602943525907879 +"antioxidant",0.277166666666667,1.32589927173518,0.0107472975039914,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0557516058019556 +"HMGCR inhibitor",0.271583333333333,1.73015613895149,1.55365513866256e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"HCC95, H1648, H520, H460, H1703",6.4476688254496e-05 +"calcium channel blocker",0.251666666666667,0.952012732280531,0.868582317371563,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.991100527108917 +"phosphodiesterase inhibitor",0.246083333333333,1.00378288655134,0.701629779750684,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.910287367414993 +"HCV inhibitor",0.24425,1.23272662493279,0.0983053295123219,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.281356632742163 +"benzodiazepine receptor agonist",0.229416666666667,0.907554401908912,0.94361920760397,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476 +"PARP inhibitor",0.228416666666667,1.11180790184549,0.33098974305323,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.602943525907879 +"KIT inhibitor",0.198833333333333,1.14213554627312,0.315300755570576,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602943525907879 +"AP inhibitor",0.196833333333333,1.07903541380365,0.444318244172752,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.737568285326769 +"PDGFR tyrosine kinase receptor inhibitor",0.191333333333333,1.07097893480118,0.547869434390149,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.833620703105775 +"PPAR receptor agonist",0.189083333333333,1.2938439879489,0.0418206406591395,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1650, H460",0.150917964117764 +"progesterone receptor agonist",0.174,1.04605127633748,0.625673367330335,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.865514824806963 +"BCL inhibitor",0.150166666666667,1.06292519477947,0.575847572613479,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.838514886437171 +"MDM inhibitor",0.145,1.65976723450226,7.89329835102124e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H520, HCC44",0.000163785940783691 +"VEGFR inhibitor",0.134583333333333,0.885227290621231,0.973314179502101,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476 +"glycogen synthase kinase inhibitor",0.128166666666667,1.00884495910678,0.758129022004787,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.953404679187838 +"tyrosine kinase inhibitor",0.127916666666667,0.828150892962841,0.995163006002476,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476 +"AKT inhibitor",0.1195,1.18522023269939,0.211749384719054,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.475005376531932 +"microtubule inhibitor",0.0925833333333333,1.12085344580355,0.44055380916358,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.737568285326769 +"DNA inhibitor",0.0918333333333333,0.924596209983121,0.95776117019698,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476 +"histamine receptor antagonist",0.0738333333333333,0.974568700254195,0.880207313818108,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.991100527108917 +"phosphatase inhibitor",0.06675,1.05524647056333,0.643564991193952,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.875670397854066 +"cyclooxygenase inhibitor",0.0648333333333334,0.877587378020335,0.986282704690237,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476 +"bacterial 50S ribosomal subunit inhibitor",0.0401666666666667,0.999421544816012,0.834133979759095,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.991100527108917 +"protein synthesis inhibitor",0.00633333333333332,0.970586264568841,0.883631795253734,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.991100527108917 +"adrenergic receptor agonist",0.00149999999999991,1.09716862878958,0.527743404741443,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.826466086670562 +"glutamate receptor antagonist",-0.000666666666666704,1.08539011280263,0.573166268556998,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.838514886437171 +"growth factor receptor inhibitor",-0.0109166666666666,1.15885040671845,0.298080376945264,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602943525907879 +"tubulin polymerization inhibitor",-0.0303333333333334,1.29596649320696,0.0352119261448867,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.139170946191695 +"Aurora kinase inhibitor",-0.0324166666666666,1.09028140306931,0.526306866263577,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.826466086670562 +"JAK inhibitor",-0.0428333333333334,0.950117488747704,0.919381554363839,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476 +"sterol demethylase inhibitor",-0.07425,1.35497401014994,0.0152566557027169,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0703501346291945 +"PI3K inhibitor",-0.103,0.951020122146358,0.876586807084671,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.991100527108917 +"HDAC inhibitor",-0.10475,1.12594252436873,0.366112865007304,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.646539740332048 +"ribonucleotide reductase inhibitor",-0.15,1.40035015101743,0.00280732489417635,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1299",0.0204332801394444 +"CDK inhibitor",-0.1545,1.23740994162661,0.095367777261869,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.281356632742163 +"Abl kinase inhibitor",-0.172083333333333,0.988868357663384,0.792156974208221,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.979765350307264 +"retinoid receptor agonist",-0.173166666666667,1.14609343053485,0.301230536905824,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602943525907879 +"CC chemokine receptor antagonist",-0.20775,1.07228999851211,0.552399261094188,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.833620703105775 +"androgen receptor antagonist",-0.226583333333333,1.17285521530179,0.174829153168707,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.414594848942935 +"adenosine receptor antagonist",-0.22725,1.27450982556218,0.162015566006902,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1299",0.395508587605083 +"MET inhibitor",-0.2415,1.24277354771861,0.0321086086443673,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.133250725874124 +"estrogen receptor antagonist",-0.260333333333333,1.50406469477234,6.18068573204134e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.000854994859599053 +"Bcr.Abl kinase inhibitor",-0.266916666666667,1.10478014746936,0.332711407152,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602943525907879 +"glucocorticoid receptor agonist",-0.312083333333333,0.911319468815642,0.880453658120564,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.991100527108917 +"DNA synthesis inhibitor",-0.316583333333333,0.949657111165856,0.802699323143301,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.979765350307264 +"adrenergic receptor antagonist",-0.325666666666667,0.878351900212017,0.924528929198808,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476 +"topoisomerase inhibitor",-0.337333333333333,1.36859551985592,0.0012103587680913,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1975, H1299, H1703",0.0100459777751578 +"acetylcholine receptor antagonist",-0.391583333333333,1.53897719625928,2.6234296837352e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1650, H2126, H460",7.25815545833406e-05 +"thymidylate synthase inhibitor",-0.40075,0.981132566800411,0.598669030784633,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.842195416188551 +"mTOR inhibitor",-0.417333333333333,1.01538244772672,0.334161472189909,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.602943525907879 +"PLK inhibitor",-0.421666666666667,1.74493466058101,1.3541656713242e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,6,"H1650, H1648, H2126, H520, H1299, H1703",6.4476688254496e-05 +"EGFR inhibitor",-0.451333333333333,1.1625235351153,0.0540564160985525,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.179467301447194 +"vitamin D receptor agonist",-0.45875,1.19189330860229,0.0405749206986854,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.150917964117764 +"protein tyrosine kinase inhibitor",-0.502083333333333,1.10066066592531,0.146638231043738,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.380342911769697 +"estrogen receptor agonist",-0.52825,0.982934301420543,0.400779022557223,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.693013726505198 +"src inhibitor",-0.532666666666667,0.947837570792623,0.493132394210983,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.802548798421796 +"DNA alkylating agent",-0.551,0.733577535097688,0.930470885321363,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476 +"CHK inhibitor",-0.881833333333333,1.06082590751763,0.0254858350329839,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.111332858301982 diff --git a/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_results.csv b/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_results.csv new file mode 100644 index 0000000..a1b9600 --- /dev/null +++ b/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_results.csv @@ -0,0 +1,995 @@ +"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig" +"H1650","Pearson.est","EGFR inhibitor",-0.56936,-1.51,0.0998,1075,0.499,"AST.1306, CNX.2006, gefitinib, ARRY.334543, WZ8040, dacomitinib, neratinib, PD.153035, lapatinib, AZD8931, rociletinib, osimertinib, XL.647, pelitinib, canertinib, vandetanib, WZ.3146, BMS.599626, AEE788, PD.168393, afatinib, poziotinib, TAK.285, icotinib, erlotinib, GW.583340",1.00086945871263,0.30189945437661,FALSE +"H1650","Pearson.est","Abl kinase inhibitor",0.32161,0.812,0.7,327,0.861,"KW.2449, tozasertib, imatinib",0.154901959985743,0.0649968485463452,FALSE +"H1650","Pearson.est","acetylcholine receptor agonist",0.67274,1.69,0.0297,467,0.201,"xanomeline, oxiracetam, nefiracetam, tremorine, nicotine",1.52724355068279,0.696803942579511,TRUE +"H1650","Pearson.est","acetylcholine receptor antagonist",-0.717,-1.9,0.0067,1241,0.192,"hyoscyamine, diphemanil, iododexetimide, darifenacin",2.17392519729917,0.71669877129645,TRUE +"H1650","Pearson.est","adenosine receptor antagonist",-0.2639,-0.711,0.786,1044,0.911,"MRS.1220, CGS.15943, theophylline",0.104577453960592,0.0404816230270017,FALSE +"H1650","Pearson.est","adrenergic receptor agonist",-0.39144,-1.06,0.365,1335,0.857,"methyldopa, A61603, isoetharine, xylazine",0.437707135543525,0.0670191780768018,FALSE +"H1650","Pearson.est","adrenergic receptor antagonist",-0.28236,-0.756,0.766,1287,0.932,"naftidrofuryl, metoprolol, prazosin, practolol",0.115771230367396,0.0305840876460186,FALSE +"H1650","Pearson.est","AKT inhibitor",0.4296,1.07,0.358,445,0.631,"uprosertib, GDC.0068, ONC201, CCT128930, AT7867, palomid.529",0.446116973356126,0.199970640755866,FALSE +"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.37475,-0.989,0.448,1391,0.861,"lorlatinib, AP26113",0.348721986001856,0.0649968485463452,FALSE +"H1650","Pearson.est","androgen receptor antagonist",-0.56788,-1.45,0.112,1245,0.537,"enzalutamide, flutamide",0.950781977329818,0.270025714300444,FALSE +"H1650","Pearson.est","antioxidant",0.3826,0.962,0.477,170,0.736,"mesna, benfotiamine",0.321481620959886,0.133122185662501,FALSE +"H1650","Pearson.est","AP inhibitor",-0.32144,-0.854,0.63,972,0.931,"GDC.0152, birinapant, tanshinone.i",0.200659450546418,0.0310503190186574,FALSE +"H1650","Pearson.est","ATPase inhibitor",0.47922,1.22,0.234,334,0.457,"evodiamine, ouabain, NMS.873, omeprazole, thonzonium, digoxin",0.630784142589857,0.34008379993015,FALSE +"H1650","Pearson.est","Aurora kinase inhibitor",0.62846,1.58,0.0474,351,0.293,"barasertib, GSK1070916, PHA.680632, AMG900, CCT137690, danusertib, MK.8745, KW.2449, CCT129202, tozasertib, alisertib, ENMD.2076, SNS.314, barasertib.HQPA, PF.03814735",1.32422165832591,0.533132379645891,FALSE +"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.39884,1.01,0.42,93,0.695,"valnemulin, azalomycin.b",0.3767507096021,0.158015195409886,FALSE +"H1650","Pearson.est","bacterial DNA gyrase inhibitor",-0.23755,-0.634,0.904,1146,0.918,"sparfloxacin, sarafloxacin, lomefloxacin",0.0438315695246367,0.0371573187987575,FALSE +"H1650","Pearson.est","BCL inhibitor",0.52502,1.32,0.175,326,0.387,"venetoclax, oridonin, gossypol, navitoclax",0.756961951313706,0.412289034981089,FALSE +"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.2574,0.633,0.892,327,0.929,"tozasertib, imatinib",0.0496351456238769,0.0319842860063582,FALSE +"H1650","Pearson.est","benzodiazepine receptor agonist",-0.31935,-0.828,0.645,1300,0.906,"gamma.aminobutyric.acid, indiplon, bentazepam",0.190440285364732,0.0428718023231869,FALSE +"H1650","Pearson.est","bromodomain inhibitor",0.76472,1.94,0.00179,260,0.104,"I.BET.762, JQ1...., bromosporine, I.BET151",2.74714696902011,0.98296666070122,TRUE +"H1650","Pearson.est","calcium channel blocker",0.31918,0.804,0.699,84,0.83,"cinnarazine",0.155522824254319,0.0809219076239261,FALSE +"H1650","Pearson.est","CC chemokine receptor antagonist",-0.37991,-0.965,0.497,1066,0.868,"RS.504393, ZK811752, MK.0812, UNBS.5162",0.303643611266668,0.0614802748235081,FALSE +"H1650","Pearson.est","CDK inhibitor",0.57382,1.47,0.095,386,0.345,"PHA.793887, indisulam, JNJ.7706621, alvocidib, R547, AZD5438, ribociclib, palbociclib, AT.7519, PHA.848125, TG.02, indirubin, aminopurvalanol.a, abemaciclib, kenpaullone, BMS.265246",1.02227639471115,0.462180904926726,FALSE +"H1650","Pearson.est","CHK inhibitor",-0.81665,-2.19,0,1253,0.0229,"PF.477736, AZD7762, LY2606368, CHIR.124",Inf,1.64016451766011,TRUE +"H1650","Pearson.est","cyclooxygenase inhibitor",-0.32134,-0.849,0.598,1136,0.903,"FR.122047, indoprofen, pterostilbene, metoxibutropate, FK.3311, naproxen",0.223298816011589,0.0443122496864942,FALSE +"H1650","Pearson.est","cytochrome P450 inhibitor",-0.49631,-1.28,0.196,1105,0.754,"morin, clotrimazole, metyrapone",0.707743928643524,0.122628654130226,FALSE +"H1650","Pearson.est","DNA alkylating agent",0.33373,0.841,0.626,371,0.881,"carmustine, estramustine, carboplatin, temozolomide, TH.302",0.20342566678957,0.0550240915879521,FALSE +"H1650","Pearson.est","DNA inhibitor",0.31335,0.789,0.725,524,0.831,"carmustine, oxaliplatin, carboplatin, valrubicin, chlorambucil, pibenzimol, melphalan, mechlorethamine",0.139661993429006,0.080398976215889,FALSE +"H1650","Pearson.est","DNA methyltransferase inhibitor",0.70879,1.77,0.0223,83,0.205,"decitabine, azacitidine, disulfiram",1.65169513695184,0.688246138944246,TRUE +"H1650","Pearson.est","DNA polymerase inhibitor",0.51458,1.32,0.166,278,0.387,"trifluridine, foscarnet, idoxuridine",0.779891911959945,0.412289034981089,FALSE +"H1650","Pearson.est","DNA synthesis inhibitor",-0.36679,-0.963,0.473,1112,0.829,"altretamine, nelarabine, artemisinin, artesunate, CB.10.277, estramustine.phosphate",0.325138859262188,0.0814454694497265,FALSE +"H1650","Pearson.est","dopamine receptor antagonist",0.26904,0.684,0.838,216,0.913,"mesoridazine, ziprasidone, paliperidone, raclopride",0.0767559813697235,0.039529222465701,FALSE +"H1650","Pearson.est","estrogen receptor agonist",-0.47954,-1.26,0.208,1175,0.721,"levonorgestrel, estradiol, estradiol.cypionate",0.681936665037238,0.142064735280571,FALSE +"H1650","Pearson.est","estrogen receptor antagonist",-0.62301,-1.67,0.0383,1059,0.372,"raloxifene, toremifene, fulvestrant",1.41680122603138,0.429457060118102,FALSE +"H1650","Pearson.est","FGFR inhibitor",0.33045,0.835,0.634,190,0.867,"dovitinib, nintedanib",0.197910742118267,0.0619809025237897,FALSE +"H1650","Pearson.est","FLT3 inhibitor",0.53599,1.34,0.171,325,0.419,"sorafenib, KW.2449, dovitinib, tozasertib, TG.02, ENMD.2076, sunitinib, TG.101348, tandutinib",0.767003889607846,0.377785977033705,FALSE +"H1650","Pearson.est","glucocorticoid receptor agonist",-0.276,-0.714,0.792,1316,0.937,"flumethasone.pivalate, deflazacort, triamcinolone.acetonide, clobetasol.propionate",0.101274818410506,0.0282604091122217,FALSE +"H1650","Pearson.est","glutamate receptor antagonist",-0.45502,-1.23,0.219,1054,0.719,"CPP, SIB.1757, ACDPP, JNJ.16259685, tiletamine, kynurenic.acid, MTPG, LY456236, CGP.37849",0.659555885159882,0.143271109617117,FALSE +"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.56807,1.42,0.0986,354,0.396,"indirubin, CHIR.99021, tideglusib, kenpaullone",1.00612308505879,0.402304814074488,FALSE +"H1650","Pearson.est","growth factor receptor inhibitor",0.43563,1.11,0.318,207,0.609,"danusertib, GSK1838705A, PHA.848125",0.497572880015567,0.215382707367125,FALSE +"H1650","Pearson.est","HCV inhibitor",0.49394,1.25,0.219,9,0.453,"narlaprevir",0.659555885159882,0.343901797987168,FALSE +"H1650","Pearson.est","HDAC inhibitor",0.18248,0.459,0.995,462,0.989,"vorinostat, resminostat, panobinostat, pyroxamide, R306465, givinostat, PCI.24781, belinostat, AR.42",0.00217691925427455,0.0048037084028206,FALSE +"H1650","Pearson.est","histamine receptor antagonist",-0.39043,-1.06,0.364,1103,0.857,"tecastemizole, cimetidine, astemizole, famotidine, ICI.162846, BF2.649, lafutidine, chloropyramine",0.438898616350944,0.0670191780768018,FALSE +"H1650","Pearson.est","HMGCR inhibitor",-0.61045,-1.58,0.0612,1111,0.446,"mevastatin, simvastatin, fluvastatin, pitavastatin",1.21324857785444,0.350665141287858,FALSE +"H1650","Pearson.est","HSP inhibitor",0.65387,1.65,0.024,344,0.219,"PU.H71, NVP.AUY922, BIIB021, SNX.2112, tanespimycin, ganetespib, SNX.5422, NMS.E973, XL888",1.61978875828839,0.659555885159882,TRUE +"H1650","Pearson.est","JAK inhibitor",0.3215,0.807,0.695,353,0.847,"AZD1480, tozasertib, AZ960, TG.02, filgotinib, TG.101348, atiprimod",0.158015195409886,0.0721165896692931,FALSE +"H1650","Pearson.est","KIT inhibitor",0.43683,1.09,0.318,328,0.619,"OSI.930, sorafenib, KI.8751, sunitinib, tandutinib, imatinib, masitinib",0.497572880015567,0.208309350979882,FALSE +"H1650","Pearson.est","MDM inhibitor",0.54515,1.39,0.12,201,0.365,"idasanutlin, nutlin.3, CGM097",0.920818753952375,0.437707135543525,FALSE +"H1650","Pearson.est","MEK inhibitor",0.61023,1.55,0.0679,132,0.309,"PD.0325901, cobimetinib, trametinib, AS.703026, Ro.4987655, AZD8330, refametinib, MEK162, TAK.733",1.1681302257195,0.510041520575165,FALSE +"H1650","Pearson.est","MET inhibitor",-0.30244,-0.814,0.671,1169,0.897,"PHA.665752, PF.04217903",0.173277479831008,0.0472075569559079,FALSE +"H1650","Pearson.est","microtubule inhibitor",0.3299,0.831,0.664,72,0.851,"vinflunine, vinblastine",0.177831920631982,0.0700704399154121,FALSE +"H1650","Pearson.est","mTOR inhibitor",-0.26131,-0.677,0.831,1370,0.899,"PI.103, sirolimus, SB.2343, deforolimus",0.080398976215889,0.0462403082667712,FALSE +"H1650","Pearson.est","NFkB pathway inhibitor",0.37168,0.949,0.509,125,0.735,"betulinic.acid, curcumin, bortezomib",0.293282217663241,0.133712660915805,FALSE +"H1650","Pearson.est","opioid receptor agonist",0.79244,2.02,0.00533,87,0.0813,"salvinorin.a, trimebutine",2.27327279097343,1.08990945440593,TRUE +"H1650","Pearson.est","p38 MAPK inhibitor",0.41458,1.05,0.401,175,0.645,"skepinone.l, talmapimod",0.396855627379818,0.190440285364732,FALSE +"H1650","Pearson.est","PARP inhibitor",0.72924,1.84,0.012,295,0.159,"niraparib, talazoparib, olaparib, endo.IWR.1, PJ.34",1.92081875395238,0.798602875679548,TRUE +"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.49502,1.26,0.221,400,0.458,"sorafenib, crenolanib, CP.673451, axitinib, KI.8751, dovitinib, nintedanib, sunitinib, tandutinib, imatinib, masitinib, trapidil, SU014813",0.655607726314889,0.339134521996131,FALSE +"H1650","Pearson.est","phosphatase inhibitor",-0.51624,-1.37,0.138,1351,0.627,"bis.maltolato.oxovanadium.IV., mycophenolate.mofetil, BVT.948",0.860120913598763,0.202732459169284,FALSE +"H1650","Pearson.est","phosphodiesterase inhibitor",-0.2236,-0.597,0.929,1144,0.927,"EMD.53998, enoximone, GSK256066",0.0319842860063582,0.0329202658555029,FALSE +"H1650","Pearson.est","PI3K inhibitor",0.24157,0.613,0.914,385,0.927,"CH5132799, alpelisib, buparlisib, voxtalisib, AZD6482, LY303511, PIK.75, CUDC.907, GDC.0941",0.0390538042661686,0.0329202658555029,FALSE +"H1650","Pearson.est","PLK inhibitor",0.70612,1.75,0.0226,116,0.189,"GW.843682X, rigosertib, NMS.1286937, volasertib",1.6458915608526,0.723538195826756,TRUE +"H1650","Pearson.est","potassium channel blocker",-0.3817,-1.02,0.386,1433,0.894,"ibutilide",0.413412695328245,0.0486624812040823,FALSE +"H1650","Pearson.est","PPAR receptor agonist",-0.70532,-1.86,0.012,1191,0.164,"pterostilbene, clofibrate, fenofibrate, GW.501516",1.92081875395238,0.785156151952302,TRUE +"H1650","Pearson.est","progesterone receptor agonist",-0.40049,-1.06,0.351,1148,0.857,"norgestrel, levonorgestrel, norethindrone.acetate",0.454692883534176,0.0670191780768018,FALSE +"H1650","Pearson.est","proteasome inhibitor",0.51239,1.32,0.166,381,0.387,"bortezomib, MG.132, ixazomib, carfilzomib",0.779891911959945,0.412289034981089,FALSE +"H1650","Pearson.est","protein synthesis inhibitor",0.35454,0.902,0.571,159,0.795,"tedizolid.phosphate, florfenicol, harringtonine, cycloheximide, thiostrepton",0.243363891754152,0.0996328713435297,FALSE +"H1650","Pearson.est","protein tyrosine kinase inhibitor",-0.30396,-0.798,0.709,1276,0.893,"BMS.599626, rheochrysidin",0.149353764816933,0.0491485411114536,FALSE +"H1650","Pearson.est","RAF inhibitor",0.54278,1.39,0.148,252,0.365,"sorafenib, dabrafenib, SB.590885, AZ.628",0.829738284605043,0.437707135543525,FALSE +"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.39165,0.988,0.451,481,0.711,"sorafenib, sunitinib, cabozantinib, regorafenib",0.345823458122039,0.148130399270234,FALSE +"H1650","Pearson.est","retinoid receptor agonist",-0.28212,-0.721,0.786,1108,0.958,"AM.580, fenretinide, LE.135, adapalene",0.104577453960592,0.0186344909214556,FALSE +"H1650","Pearson.est","ribonucleotide reductase inhibitor",-0.34231,-0.897,0.559,1310,0.882,"hydroxyurea, clofarabine",0.252588192113577,0.0545314148681803,FALSE +"H1650","Pearson.est","serotonin receptor agonist",0.671,1.69,0.031,183,0.201,"aripiprazole, pardoprunox, zolmitriptan, ipsapirone",1.50863830616573,0.696803942579511,TRUE +"H1650","Pearson.est","serotonin receptor antagonist",0.57415,1.47,0.0976,280,0.345,"aripiprazole, ziprasidone, paliperidone, pirenperone, SB.200646",1.01055018233331,0.462180904926726,FALSE +"H1650","Pearson.est","sodium channel blocker",-0.26034,-0.696,0.819,1198,0.903,"oxcarbazepine, quinidine, cibenzoline",0.0867160982395816,0.0443122496864942,FALSE +"H1650","Pearson.est","src inhibitor",-0.34261,-0.931,0.519,1023,0.852,"bosutinib, saracatinib, ZM.306416, dasatinib, PP.1",0.284832642151542,0.0695604052332999,FALSE +"H1650","Pearson.est","sterol demethylase inhibitor",-0.37912,-1.01,0.419,943,0.863,"lanoconazole, posaconazole, terconazole",0.377785977033705,0.0639892042847904,FALSE +"H1650","Pearson.est","TGF beta receptor inhibitor",0.55827,1.41,0.133,558,0.384,"repsox, SB.431542, LY2109761, D.4476",0.876148359032914,0.415668775632469,FALSE +"H1650","Pearson.est","thymidylate synthase inhibitor",0.48271,1.24,0.223,267,0.447,"carmofur, trifluridine, capecitabine",0.651695136951839,0.349692476868064,FALSE +"H1650","Pearson.est","topoisomerase inhibitor",0.25748,0.661,0.851,567,0.92,"topotecan, SN.38, nemorubicin, dexrazoxane, daunorubicin, valrubicin, idarubicin, genz.644282, rubitecan, etoposide.phosphate, fleroxacin, TAS.103, voreloxin",0.0700704399154121,0.0362121726544447,FALSE +"H1650","Pearson.est","tubulin polymerization inhibitor",0.60463,1.53,0.0724,497,0.308,"fosbretabulin, verubulin, docetaxel, vindesine, vinblastine, albendazole, taltobulin, epothilone.b, BNC105, plinabulin, KX2.391, paclitaxel, combretastatin.A.4, oxibendazole, dolastatin.10, vincristine, podophyllotoxin, fenbendazole, ABT.751, parbendazole, indibulin",1.14026143380285,0.511449283499556,FALSE +"H1650","Pearson.est","tyrosine kinase inhibitor",0.29543,0.742,0.747,120,0.858,"sorafenib, tivantinib, UNC2250, PP.121",0.126679398184601,0.0665127121512946,FALSE +"H1650","Pearson.est","VEGFR inhibitor",0.31419,0.784,0.707,286,0.819,"OSI.930, sorafenib, axitinib, KI.8751, dovitinib, nintedanib, semaxanib, tivozanib, ENMD.2076, sunitinib",0.150580586203101,0.0867160982395816,FALSE +"H1650","Pearson.est","vitamin D receptor agonist",-0.4232,-1.09,0.358,1179,0.986,"doxercalciferol, paricalcitol",0.446116973356126,0.0061230850587888,FALSE +"HCC95","Pearson.est","EGFR inhibitor",-0.72735,-1.93,0.0103,1177,0.337,"BIBX.1382, pelitinib, WZ.4002, salvianolic.acid.B, ARRY.334543, brigatinib, BIBU.1361, BMS.599626, AEE788, rociletinib, poziotinib, WZ8040, icotinib, BMS.690514, CNX.2006, AZD8931, erlotinib, dacomitinib, WZ.3146, osimertinib, afatinib, canertinib, tucatinib, gefitinib, neratinib, CUDC.101, XL.647, CP.724714, lapatinib",1.98716277529483,0.472370099128661,FALSE +"HCC95","Pearson.est","Abl kinase inhibitor",0.24134,0.607,0.914,148,0.979,"KW.2449, GZD824",0.0390538042661686,0.00921730819686218,FALSE +"HCC95","Pearson.est","acetylcholine receptor agonist",0.70826,1.74,0.0166,351,0.203,"tremorine, xanomeline, nefiracetam, oxiracetam",1.77989191195995,0.692503962086787,TRUE +"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.49272,-1.26,0.22,1343,0.714,"dicycloverine, diphemanil",0.657577319177794,0.146301788223826,FALSE +"HCC95","Pearson.est","adenosine receptor antagonist",-0.47138,-1.25,0.199,1353,0.67,"PSB.1115, CGS.15943",0.701146923590293,0.173925197299174,FALSE +"HCC95","Pearson.est","adrenergic receptor agonist",-0.31143,-0.81,0.687,1327,0.812,"buphenine, methyldopa, lidamidine",0.16304326294045,0.0904439707588247,FALSE +"HCC95","Pearson.est","adrenergic receptor antagonist",-0.32106,-0.842,0.612,1375,0.818,"dihydroergocristine, atenolol......, practolol",0.213248577854439,0.087246696328677,FALSE +"HCC95","Pearson.est","AKT inhibitor",-0.36201,-0.944,0.492,1112,0.827,"GSK2110183, AT7867, GDC.0068, A.674563, uprosertib",0.30803489723264,0.0824944904474534,FALSE +"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.55548,-1.49,0.0882,1188,0.539,"NVP.TAE684, brigatinib, CEP.37440, AZD3463",1.05453141486818,0.268411234813261,FALSE +"HCC95","Pearson.est","androgen receptor antagonist",0.34871,0.867,0.625,230,0.932,"flutamide",0.204119982655925,0.0305840876460186,FALSE +"HCC95","Pearson.est","antioxidant",0.57903,1.41,0.104,494,0.595,"benfotiamine, trolox, mesna, chlorogenic.acid, taurine",0.98296666070122,0.22548303427145,FALSE +"HCC95","Pearson.est","AP inhibitor",0.38663,0.955,0.476,366,0.846,"idronoxil, birinapant, GDC.0152",0.322393047279507,0.0726296369609765,FALSE +"HCC95","Pearson.est","ATPase inhibitor",0.29365,0.726,0.782,13,0.957,"k.strophanthidin",0.106793246940152,0.0190880622231565,FALSE +"HCC95","Pearson.est","Aurora kinase inhibitor",0.31667,0.774,0.716,417,1,"KW.2449, ZM.447439, SNS.314, aurora.a.inhibitor.i, AMG900, MK.5108, PF.03814735, AT.9283, alisertib, MLN.8054",0.145086977692144,0,FALSE +"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.28029,0.687,0.854,485,0.962,"tilmicosin, josamycin, dirithromycin",0.068542129310995,0.0168249279621871,FALSE +"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.52996,1.32,0.162,311,0.702,"nadifloxacin, finafloxacin, norfloxacin, trovafloxacin",0.790484985457369,0.153662887870195,FALSE +"HCC95","Pearson.est","BCL inhibitor",-0.22274,-0.587,0.942,1180,0.963,"venetoclax, obatoclax",0.0259490972071227,0.0163737128754655,FALSE +"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.35015,-0.938,0.515,1270,0.801,"dasatinib, metatinib, imatinib",0.288192770958809,0.0963674839157623,FALSE +"HCC95","Pearson.est","benzodiazepine receptor agonist",0.21607,0.523,0.977,21,0.991,"CGS.20625",0.0101054362812269,0.00392634551472468,FALSE +"HCC95","Pearson.est","bromodomain inhibitor",0.48228,1.19,0.266,37,0.77,"PFI.1",0.575118363368933,0.113509274827518,FALSE +"HCC95","Pearson.est","calcium channel blocker",-0.31788,-0.804,0.687,1236,0.795,"mibefradil, tetrandrine, penfluridol",0.16304326294045,0.0996328713435297,FALSE +"HCC95","Pearson.est","CC chemokine receptor antagonist",0.42502,1.04,0.398,219,0.91,"MK.0812, UNBS.5162",0.400116927926312,0.0409586076789064,FALSE +"HCC95","Pearson.est","CDK inhibitor",-0.46168,-1.21,0.227,1054,0.634,"aminopurvalanol.a, CR8..R., BMS.265246, JNJ.7706621, PHA.848125, PHA.793887, alvocidib, ribociclib, AT.7519, palbociclib, arcyriaflavin.a, dinaciclib, BMS.387032",0.643974142806877,0.197910742118267,FALSE +"HCC95","Pearson.est","CHK inhibitor",-0.67205,-1.8,0.0202,1030,0.393,"CHIR.124, LY2603618, AZD7762, LY2606368, SCH.900776, PF.477736",1.69464863055338,0.405607449624573,FALSE +"HCC95","Pearson.est","cyclooxygenase inhibitor",0.39743,0.967,0.477,117,0.852,"suxibuzone, ketoprofen, AM.404, metoxibutropate, phenylbutazone",0.321481620959886,0.0695604052332999,FALSE +"HCC95","Pearson.est","cytochrome P450 inhibitor",0.65294,1.62,0.0383,244,0.264,"eplerenone, cobicistat, metyrapone",1.41680122603138,0.578396073130169,FALSE +"HCC95","Pearson.est","DNA alkylating agent",-0.39787,-1.07,0.344,1206,0.687,"dianhydrogalactitol, mitomycin.c, dacarbazine",0.46344155742847,0.16304326294045,FALSE +"HCC95","Pearson.est","DNA inhibitor",0.24581,0.606,0.932,428,0.958,"sangivamycin, pibenzimol, metronidazole, valrubicin, nimorazole, tirapazamine",0.0305840876460186,0.0186344909214556,FALSE +"HCC95","Pearson.est","DNA methyltransferase inhibitor",0.29839,0.737,0.769,288,0.965,"decitabine, RG108",0.114073660198569,0.0154726866562074,FALSE +"HCC95","Pearson.est","DNA polymerase inhibitor",-0.30783,-0.821,0.653,1364,0.822,"cidofovir",0.185086818724926,0.0851281824599496,FALSE +"HCC95","Pearson.est","DNA synthesis inhibitor",0.34326,0.846,0.635,97,0.942,"artesunate, nelarabine, CB.10.277",0.197226274708024,0.0259490972071227,FALSE +"HCC95","Pearson.est","dopamine receptor antagonist",0.40454,0.99,0.442,187,0.872,"nemonapride, paliperidone, raclopride, clebopride",0.354577730650908,0.0594835150674328,FALSE +"HCC95","Pearson.est","estrogen receptor agonist",-0.46816,-1.22,0.249,1367,0.667,"equol, levonorgestrel",0.603800652904264,0.175874166083451,FALSE +"HCC95","Pearson.est","estrogen receptor antagonist",0.38704,0.953,0.523,381,0.82,"fulvestrant, raloxifene, danazol, toremifene",0.281498311132726,0.0861861476162833,FALSE +"HCC95","Pearson.est","FGFR inhibitor",0.31238,0.763,0.745,5,0.975,"MK.2461",0.127843727251707,0.0109953843014632,FALSE +"HCC95","Pearson.est","FLT3 inhibitor",0.34836,0.842,0.668,54,0.921,"KW.2449, gilteritinib",0.175223537524454,0.0357403698031511,FALSE +"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.34976,-0.926,0.535,1022,0.788,"prednisolone, desonide, dexamethasone.acetate, deflazacort, halobetasol.propionate, ciclesonide, triamcinolone.acetonide, betamethasone, beclomethasone.dipropionate, fluorometholone, difluprednate, fluticasone.propionate, methylprednisolone, prednisolone.acetate, halcinonide, flumethasone.pivalate, flumethasone",0.271646217978772,0.103473782510445,FALSE +"HCC95","Pearson.est","glutamate receptor antagonist",0.24351,0.612,0.912,11,0.997,"JNJ.16259685",0.0400051616715838,0.00130484168834428,FALSE +"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.5311,1.32,0.173,347,0.702,"kenpaullone, LY2090314, GSK.3.inhibitor.IX",0.761953896871205,0.153662887870195,FALSE +"HCC95","Pearson.est","growth factor receptor inhibitor",-0.60876,-1.61,0.0551,1293,0.398,"GW.441756, AZD3463",1.25884840114821,0.400116927926312,FALSE +"HCC95","Pearson.est","HCV inhibitor",0.40707,1,0.436,196,0.885,"mericitabine, narlaprevir",0.360513510731414,0.0530567293021746,FALSE +"HCC95","Pearson.est","HDAC inhibitor",0.30458,0.761,0.741,478,0.952,"RGFP966, R306465, romidepsin, entinostat, RG2833, panobinostat, AR.42, nexturastat.a, belinostat, JNJ.26481585, mocetinostat",0.130181792020672,0.0213630516155257,FALSE +"HCC95","Pearson.est","histamine receptor antagonist",0.41016,1.03,0.404,208,0.854,"ICI.162846, BF2.649, famotidine, epinastine, nizatidine",0.393618634889395,0.068542129310995,FALSE +"HCC95","Pearson.est","HMGCR inhibitor",0.92228,2.24,0,118,0.00185,"mevastatin, pitavastatin, lovastatin, fluvastatin, atorvastatin, simvastatin",Inf,2.73282827159699,TRUE +"HCC95","Pearson.est","HSP inhibitor",0.73688,1.78,0.00322,172,0.196,"SNX.5422, BIIB021, ganetespib, tanespimycin, XL888, NVP.AUY922, SNX.2112, KW.2478",2.49214412830417,0.707743928643524,TRUE +"HCC95","Pearson.est","JAK inhibitor",-0.35301,-0.966,0.428,1040,0.821,"TG.101209, filgotinib, TG.101348, CEP.33779, atiprimod, pacritinib, ruxolitinib",0.368556230986828,0.0856568428805592,FALSE +"HCC95","Pearson.est","KIT inhibitor",-0.33293,-0.898,0.561,1232,0.809,"tandutinib, dasatinib, pazopanib, lenvatinib, imatinib",0.251037138743839,0.0920514783877277,FALSE +"HCC95","Pearson.est","MDM inhibitor",0.68899,1.7,0.024,427,0.216,"AMG.232, CGM097, serdemetan, RITA",1.61978875828839,0.665546248849069,TRUE +"HCC95","Pearson.est","MEK inhibitor",0.4747,1.19,0.279,391,0.77,"PD.184352, arctigenin, refametinib, PD.318088, nobiletin, TAK.733, AZD8330, Ro.4987655",0.554395796726402,0.113509274827518,FALSE +"HCC95","Pearson.est","MET inhibitor",0.77029,1.9,0.00322,278,0.0897,"NVP.BVU972, AMG458, PF.04217903, PHA.665752",2.49214412830417,1.04720755695591,TRUE +"HCC95","Pearson.est","microtubule inhibitor",0.4118,1.03,0.408,382,0.854,"cytochalasin.b, secnidazole, estramustine.phosphate, cabazitaxel, vinblastine",0.38933983691012,0.068542129310995,FALSE +"HCC95","Pearson.est","mTOR inhibitor",-0.44389,-1.2,0.245,1007,0.607,"deforolimus, sirolimus, everolimus, XL388, OSI.027, MLN0128, WAY.600, PI.103, PP242, torin.1, PF.05212384, PKI.179, ku.0063794, AZD8055, WYE.354, GDC.0980, WYE.125132",0.610833915635468,0.216811308924742,FALSE +"HCC95","Pearson.est","NFkB pathway inhibitor",0.49999,1.21,0.226,399,0.824,"BAY.11.7085, parthenolide, BAY.11.7082, tyloxapol",0.645891560852599,0.0840727883028842,FALSE +"HCC95","Pearson.est","opioid receptor agonist",0.67406,1.65,0.037,348,0.257,"cebranopadol, trimebutine, BW.180C, spiradoline",1.431798275933,0.590066876668705,FALSE +"HCC95","Pearson.est","p38 MAPK inhibitor",0.31552,0.768,0.719,405,0.995,"TAK.715, VX.702, CMPD.1",0.143271109617117,0.00217691925427455,FALSE +"HCC95","Pearson.est","PARP inhibitor",0.50912,1.24,0.22,132,0.87,"AG.14361, AZD2461",0.657577319177794,0.0604807473813815,FALSE +"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.20641,-0.55,0.964,1232,0.962,"tandutinib, dasatinib, pazopanib, lenvatinib, imatinib",0.0159229660971692,0.0168249279621871,FALSE +"HCC95","Pearson.est","phosphatase inhibitor",0.44608,1.11,0.303,334,0.827,"bis.maltolato.oxovanadium.IV., CID.5458317, BVT.948, GSK2830371, alexidine",0.518557371497695,0.0824944904474534,FALSE +"HCC95","Pearson.est","phosphodiesterase inhibitor",0.46698,1.15,0.305,354,0.822,"GSK256066, avanafil, EMD.53998, zardaverine, anagrelide, YM.976",0.515700160653214,0.0851281824599496,FALSE +"HCC95","Pearson.est","PI3K inhibitor",-0.43933,-1.14,0.284,1262,0.632,"alpelisib, PF.05212384, PKI.179, BGT226, PI3K.IN.2, taselisib, GDC.0980, idelalisib",0.546681659952962,0.199282921717615,FALSE +"HCC95","Pearson.est","PLK inhibitor",-0.43648,-1.15,0.285,1098,0.655,"GW.843682X, volasertib, NMS.1286937",0.54515513999149,0.183758700008217,FALSE +"HCC95","Pearson.est","potassium channel blocker",0.28786,0.69,0.845,231,0.982,"meglitinide, dofetilide",0.0731432910503077,0.00788851221305034,FALSE +"HCC95","Pearson.est","PPAR receptor agonist",0.45632,1.12,0.326,371,0.85,"S26948, ciprofibrate, clofibrate, fenofibrate",0.486782399932061,0.0705810742857073,FALSE +"HCC95","Pearson.est","progesterone receptor agonist",0.49207,1.21,0.27,318,0.824,"norethindrone, tanaproget, dienogest, norgestrel, danazol",0.568636235841013,0.0840727883028842,FALSE +"HCC95","Pearson.est","proteasome inhibitor",-0.26894,-0.716,0.776,387,0.877,"ixazomib, ixazomib.citrate, bortezomib, oprozomib, carfilzomib, ONX.0914, delanzomib, MG.132",0.110138278741812,0.0570004066339595,FALSE +"HCC95","Pearson.est","protein synthesis inhibitor",0.25891,0.625,0.901,453,1,"florfenicol, azomycin..2.nitroimidazole., mercaptopurine, clindamycin.phosphate, brefeldin.a, puromycin, methacycline, cycloheximide",0.045275209020937,0,FALSE +"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.65889,-1.78,0.0241,1229,0.295,"tyrphostin.A9, NVP.TAE226, BMS.599626, AV.412, CP.724714",1.61798295742513,0.530177984021837,FALSE +"HCC95","Pearson.est","RAF inhibitor",-0.41051,-1.12,0.296,1208,0.631,"TAK.632, GDC.0879, SB.590885, CEP.32496, AZ.628",0.528708288941061,0.199970640755866,FALSE +"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.28383,-0.752,0.748,409,0.851,"sorafenib, apatinib, cabozantinib, vandetanib, regorafenib, sunitinib",0.126098402135539,0.0700704399154121,FALSE +"HCC95","Pearson.est","retinoid receptor agonist",-0.52117,-1.37,0.172,1161,0.621,"bexarotene, adarotene, tamibarotene, adapalene, CD.437",0.764471553092451,0.20690839982342,FALSE +"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.44705,1.1,0.333,273,0.809,"cytarabine, clofarabine, hydroxyurea, fludarabine, triapine",0.47755576649368,0.0920514783877277,FALSE +"HCC95","Pearson.est","serotonin receptor antagonist",0.61278,1.53,0.0424,92,0.379,"tropisetron, lerisetron, paliperidone",1.37263414340727,0.421360790031928,FALSE +"HCC95","Pearson.est","sodium channel blocker",0.19316,0.478,0.991,322,0.986,"A.803467, oxcarbazepine, mexiletine",0.00392634551472468,0.0061230850587888,FALSE +"HCC95","Pearson.est","src inhibitor",-0.52822,-1.39,0.14,1270,0.66,"dasatinib, PP.1, saracatinib",0.853871964321762,0.180456064458131,FALSE +"HCC95","Pearson.est","sterol demethylase inhibitor",0.40165,0.972,0.49,86,0.874,"sulconazole",0.309803919971486,0.058488567365597,FALSE +"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.49906,-1.3,0.179,942,0.699,"SB.525334, repsox, LY2109761, adaprev, SB.431542",0.747146969020107,0.155522824254319,FALSE +"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.34012,-0.874,0.616,1283,0.822,"carmofur",0.210419287835575,0.0851281824599496,FALSE +"HCC95","Pearson.est","topoisomerase inhibitor",0.35906,0.889,0.584,493,0.919,"nemorubicin, etoposide, camptothecin, beta.lapachone, valrubicin, doxorubicin, rubitecan, amonafide, fleroxacin, etoposide.phosphate, daunorubicin, voreloxin, teniposide, exatecan.mesylate",0.233587152887601,0.0366844886138887,FALSE +"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.32468,-0.87,0.605,968,0.797,"fosbretabulin, dolastatin.10, vinorelbine, parbendazole, mebendazole, oxibendazole, plinabulin, taltobulin, ABT.751, CYT.997, fenbendazole",0.218244625347531,0.0985416786038876,FALSE +"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.37409,-0.99,0.436,1229,0.812,"tyrphostin.A9, NVP.TAE226, dasatinib, BMS.599626, tivantinib, AV.412, CP.724714",0.360513510731414,0.0904439707588247,FALSE +"HCC95","Pearson.est","VEGFR inhibitor",-0.26801,-0.713,0.805,1276,0.854,"pazopanib, AEE788, lucitanib, SAR131675, BMS.690514, lenvatinib, XL.647",0.0942041196321315,0.068542129310995,FALSE +"HCC95","Pearson.est","vitamin D receptor agonist",-0.61933,-1.62,0.0483,1247,0.473,"tacalcitol, doxercalciferol, maxacalcitol",1.31605286924849,0.325138859262188,FALSE +"H1975","Pearson.est","EGFR inhibitor",0.33978,0.889,0.556,315,0.782,"CUDC.101, tucatinib, neratinib, dovitinib, CP.724714, brigatinib, BMS.599626, BMS.690514, lapatinib, ARRY.334543, WZ.4002, AZD8931",0.254925208417942,0.106793246940152,FALSE +"H1975","Pearson.est","Abl kinase inhibitor",-0.55165,-1.42,0.117,1025,0.513,"tozasertib, ponatinib, bafetinib, GZD824, KW.2449, bosutinib, flumatinib",0.931814138253838,0.289882634888184,FALSE +"H1975","Pearson.est","acetylcholine receptor agonist",0.33619,0.865,0.582,528,0.776,"oxiracetam, xanomeline, pilocarpine, nefiracetam",0.235077015350112,0.110138278741812,FALSE +"H1975","Pearson.est","acetylcholine receptor antagonist",-0.30081,-0.772,0.746,917,0.836,"hyoscyamine, dicycloverine, diphemanil, iododexetimide",0.127261172527331,0.0777937225609836,FALSE +"H1975","Pearson.est","adenosine receptor antagonist",-0.35786,-0.898,0.555,1438,0.734,"theophylline",0.255707016877324,0.134303940083929,FALSE +"H1975","Pearson.est","adrenergic receptor agonist",-0.44122,-1.11,0.333,1234,0.609,"xylazine, isoetharine, terbutaline, epinephrine, norepinephrine, A61603",0.47755576649368,0.215382707367125,FALSE +"H1975","Pearson.est","adrenergic receptor antagonist",-0.26637,-0.67,0.837,1190,0.874,"idazoxan, carvedilol, naftidrofuryl, atenolol...., metoprolol",0.07727454200674,0.058488567365597,FALSE +"H1975","Pearson.est","AKT inhibitor",0.3241,0.838,0.614,577,0.735,"uprosertib, GDC.0068, AZD5363, GSK2110183, CCT128930, AT7867",0.211831628858832,0.133712660915805,FALSE +"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.33363,0.86,0.614,165,0.762,"SB.505124, crizotinib, brigatinib",0.211831628858832,0.1180450286604,FALSE +"H1975","Pearson.est","androgen receptor antagonist",0.32153,0.845,0.623,243,0.744,"RU.58841, nilutamide",0.20551195334083,0.128427064454121,FALSE +"H1975","Pearson.est","antioxidant",0.45178,1.16,0.274,159,0.768,"trolox",0.562249437179612,0.114638779968488,FALSE +"H1975","Pearson.est","AP inhibitor",0.33578,0.879,0.575,340,0.775,"embelin, birinapant",0.24033215531037,0.11069829749369,FALSE +"H1975","Pearson.est","ATPase inhibitor",0.56875,1.48,0.107,300,0.471,"k.strophanthidin, digoxin, thonzonium, omeprazole, NMS.873",0.97061622231479,0.326979092871104,FALSE +"H1975","Pearson.est","Aurora kinase inhibitor",-0.38383,-0.978,0.462,1020,0.726,"GSK1070916, tozasertib, MK.8745, PF.03814735, AMG900, SNS.314, AT.9283, ZM.447439, alisertib, TAK.901, KW.2449, MK.5108, CYC116",0.335358024443874,0.139063379299906,FALSE +"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.28328,0.726,0.79,198,0.803,"azalomycin.b, radezolid",0.102372908709559,0.095284454721319,FALSE +"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.50917,-1.27,0.19,1115,0.525,"sarafloxacin, trovafloxacin, novobiocin, sparfloxacin",0.721246399047171,0.279840696594043,FALSE +"H1975","Pearson.est","BCL inhibitor",0.39791,1.05,0.392,537,0.697,"venetoclax, obatoclax, oridonin, HA14.1, navitoclax, TW.37",0.406713932979543,0.156767221901991,FALSE +"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.54824,-1.42,0.111,1025,0.513,"tozasertib, ponatinib, bafetinib, GZD824, bosutinib, flumatinib",0.954677021213343,0.289882634888184,FALSE +"H1975","Pearson.est","benzodiazepine receptor agonist",0.29417,0.769,0.762,10,0.764,"eprinomectin",0.1180450286604,0.11690664142431,FALSE +"H1975","Pearson.est","bromodomain inhibitor",-0.45247,-1.14,0.285,1163,0.586,"bromosporine, OTX015, PFI.1",0.54515513999149,0.232102383981909,FALSE +"H1975","Pearson.est","calcium channel blocker",0.61412,1.6,0.066,168,0.507,"tetrandrine, SKF.96365, cinnarazine, efonidipine.monoethanolate, SR.33805",1.18045606445813,0.294992040666664,FALSE +"H1975","Pearson.est","CC chemokine receptor antagonist",-0.34049,-0.869,0.592,1238,0.734,"UNBS.5162, MK.0812",0.22767829327708,0.134303940083929,FALSE +"H1975","Pearson.est","CDK inhibitor",0.59565,1.53,0.0877,359,0.43,"R547, AT.7519, indirubin, AZD5438, BMS.387032, TG.02, JNJ.7706621, BMS.265246, indisulam, alvocidib, P276.00, CR8..R., NU6027",1.05700040663396,0.366531544420413,FALSE +"H1975","Pearson.est","CHK inhibitor",-0.56827,-1.43,0.132,1053,0.633,"LY2603618, CHIR.124, AZD7762, LY2606368",0.87942606879415,0.198596289982645,FALSE +"H1975","Pearson.est","cyclooxygenase inhibitor",-0.515,-1.32,0.173,1088,0.605,"ramifenazone, pterostilbene, naproxen, indoprofen, FK.3311, sulfasalazine, piroxicam, acetylsalicylsalicylic.acid, metoxibutropate",0.761953896871205,0.218244625347531,FALSE +"H1975","Pearson.est","cytochrome P450 inhibitor",-0.42145,-1.07,0.349,800,0.596,"itraconazole, morin, metyrapone, clotrimazole, eplerenone, cobicistat",0.45717457304082,0.224753740259764,FALSE +"H1975","Pearson.est","DNA alkylating agent",-0.29456,-0.753,0.75,928,0.84,"mitomycin.c, melphalan, cisplatin, satraplatin, streptozotocin, cyclophosphamide, dianhydrogalactitol",0.1249387366083,0.0757207139381184,FALSE +"H1975","Pearson.est","DNA inhibitor",0.40062,1.05,0.381,329,0.697,"busulfan, nimorazole, mechlorethamine, sangivamycin, nithiamide, carmustine, metronidazole",0.419075024324381,0.156767221901991,FALSE +"H1975","Pearson.est","DNA methyltransferase inhibitor",0.52569,1.4,0.136,196,0.516,"disulfiram, azacitidine, fdcyd",0.866461091629782,0.287350298372789,FALSE +"H1975","Pearson.est","DNA polymerase inhibitor",0.30209,0.794,0.683,228,0.763,"idoxuridine, cidofovir, menadione",0.165579296318467,0.11747546204512,FALSE +"H1975","Pearson.est","DNA synthesis inhibitor",-0.50875,-1.25,0.21,1208,0.525,"artesunate, CB.10.277, estramustine.phosphate, altretamine",0.677780705266081,0.279840696594043,FALSE +"H1975","Pearson.est","dopamine receptor antagonist",0.30873,0.788,0.691,132,0.753,"mesoridazine, ziprasidone, sertindole",0.160521952625802,0.123205023799299,FALSE +"H1975","Pearson.est","estrogen receptor agonist",-0.59541,-1.5,0.0788,1314,0.656,"estradiol, estradiol.cypionate",1.10347378251044,0.18309616062434,FALSE +"H1975","Pearson.est","estrogen receptor antagonist",-0.57411,-1.46,0.0833,1216,0.654,"raloxifene, fulvestrant, toremifene",1.07935499859321,0.184422251675733,FALSE +"H1975","Pearson.est","FGFR inhibitor",0.67617,1.77,0.027,271,0.26,"dovitinib, lenvatinib, nintedanib, erdafitinib, regorafenib",1.56863623584101,0.585026652029182,FALSE +"H1975","Pearson.est","FLT3 inhibitor",0.3723,0.958,0.486,157,0.757,"sorafenib, ENMD.2076, TG.101348, dovitinib, TG.02",0.313363730737707,0.120904120499927,FALSE +"H1975","Pearson.est","glucocorticoid receptor agonist",0.57384,1.47,0.101,388,0.443,"hydrocortisone, dexamethasone.acetate, fludroxycortide, difluprednate, desonide, halcinonide, ciclesonide, rimexolone, prednisolone.hemisuccinate, fluocinolone.acetonide, triamcinolone.acetonide, flumethasone, piretanide, methylprednisolone",0.995678626217357,0.35359627377693,FALSE +"H1975","Pearson.est","glutamate receptor antagonist",-0.5002,-1.27,0.201,1239,0.525,"SIB.1757, JNJ.16259685, kynurenic.acid, MTPG, LY456236",0.696803942579511,0.279840696594043,FALSE +"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.28471,-0.72,0.806,1003,0.859,"tideglusib, LY2090314, TWS.119, AZD2858",0.0936649581949093,0.0660068361687577,FALSE +"H1975","Pearson.est","growth factor receptor inhibitor",0.43045,1.12,0.305,437,0.813,"GSK1838705A, PHA.848125, lestaurtinib",0.515700160653214,0.0899094544059319,FALSE +"H1975","Pearson.est","HCV inhibitor",0.51201,1.33,0.176,205,0.602,"narlaprevir, embelin, daclatasvir",0.75448733218585,0.220403508742175,FALSE +"H1975","Pearson.est","HDAC inhibitor",-0.27481,-0.692,0.826,1193,0.871,"M.344, SB.939, RG2833, entinostat, mocetinostat",0.0830199526796178,0.0599818449923368,FALSE +"H1975","Pearson.est","histamine receptor antagonist",-0.50196,-1.27,0.207,1015,0.525,"terfenadine, nizatidine, zolantidine, ICI.162846, pheniramine, cimetidine, ebastine, lafutidine, tiotidine, BF2.649, chloropyramine",0.684029654543082,0.279840696594043,FALSE +"H1975","Pearson.est","HMGCR inhibitor",-0.59994,-1.53,0.071,1117,0.948,"fluvastatin, mevastatin, simvastatin, pitavastatin",1.14874165128092,0.0231916626619338,FALSE +"H1975","Pearson.est","HSP inhibitor",-0.31368,-0.797,0.715,996,0.824,"VER.49009, BIIB021, NVP.AUY922, alvespimycin, ganetespib, SNX.5422",0.145693958198919,0.0840727883028842,FALSE +"H1975","Pearson.est","JAK inhibitor",0.46562,1.19,0.257,437,0.748,"AZD1480, AZ960, TG.101348, TG.02, filgotinib, TG.101209, atiprimod, baricitinib, ruxolitinib, lestaurtinib",0.590066876668705,0.126098402135539,FALSE +"H1975","Pearson.est","KIT inhibitor",0.31503,0.818,0.67,447,0.747,"sorafenib, lenvatinib, OSI.930, regorafenib, sunitinib, imatinib, pazopanib, tandutinib",0.173925197299174,0.126679398184601,FALSE +"H1975","Pearson.est","MDM inhibitor",0.46675,1.2,0.244,97,0.78,"nutlin.3, idasanutlin, CGM097",0.612610173661271,0.10790539730952,FALSE +"H1975","Pearson.est","MEK inhibitor",0.31762,0.848,0.616,355,0.76,"PD.0325901, cobimetinib, AS.703026, trametinib, MEK162, AZD8330, PD.198306, Ro.4987655",0.210419287835575,0.119186407719209,FALSE +"H1975","Pearson.est","MET inhibitor",-0.74203,-1.87,0.0138,1179,0.329,"PHA.665752, LY2801653, INC.280, PF.04217903, NVP.BVU972",1.86012091359876,0.482804102050026,FALSE +"H1975","Pearson.est","microtubule inhibitor",-0.50631,-1.28,0.19,1099,0.636,"D.64131, colchicine, cabazitaxel, estramustine.phosphate",0.721246399047171,0.196542884351586,FALSE +"H1975","Pearson.est","mTOR inhibitor",0.68659,1.78,0.0176,276,0.328,"voxtalisib, PP242, AZD2014, AZD8055, GSK2126458, XL388, OSI.027, WAY.600, torin.1, ku.0063794, WYE.354, PF.05212384, LY3023414, torin.2, MLN0128, sirolimus",1.75448733218585,0.484126156288321,FALSE +"H1975","Pearson.est","NFkB pathway inhibitor",-0.37448,-0.96,0.484,1396,0.703,"BAY.11.7082, BAY.11.7085",0.315154638355588,0.153044674980176,FALSE +"H1975","Pearson.est","opioid receptor agonist",0.41915,1.06,0.369,226,0.74,"salvinorin.a, trimebutine",0.43297363384094,0.130768280269024,FALSE +"H1975","Pearson.est","p38 MAPK inhibitor",0.41876,1.11,0.309,225,0.747,"skepinone.l, SB.242235, talmapimod",0.510041520575165,0.126679398184601,FALSE +"H1975","Pearson.est","PARP inhibitor",-0.26019,-0.661,0.875,1195,0.861,"E7449, niraparib",0.0579919469776868,0.0649968485463452,FALSE +"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.39917,1.03,0.416,447,0.705,"sorafenib, dovitinib, lenvatinib, crenolanib, nintedanib, regorafenib, sunitinib, linifanib, imatinib, axitinib, pazopanib, tandutinib",0.380906669373257,0.151810883008601,FALSE +"H1975","Pearson.est","phosphatase inhibitor",-0.34817,-0.888,0.57,1292,0.725,"BVT.948, bis.maltolato.oxovanadium.IV.",0.244125144327509,0.139661993429006,FALSE +"H1975","Pearson.est","phosphodiesterase inhibitor",-0.36672,-0.924,0.518,1192,0.739,"enoximone, EMD.53998, GSK256066, trequinsin",0.285670240254767,0.131355561605174,FALSE +"H1975","Pearson.est","PI3K inhibitor",0.51297,1.3,0.178,260,0.618,"CH5132799, voxtalisib, GSK2126458, alpelisib, CUDC.907, BGT226, PI3K.IN.2, PF.05212384, LY3023414, GDC.0941, buparlisib",0.749579997691106,0.209011524911184,FALSE +"H1975","Pearson.est","PLK inhibitor",-0.60109,-1.5,0.0799,1374,0.656,"BI.2536, GSK461364",1.09745322068601,0.18309616062434,FALSE +"H1975","Pearson.est","potassium channel blocker",0.38532,0.982,0.447,36,0.739,"ML133",0.349692476868064,0.131355561605174,FALSE +"H1975","Pearson.est","PPAR receptor agonist",-0.42609,-1.08,0.356,1101,0.606,"pterostilbene, GW.501516, fenofibrate",0.448550002027125,0.217527375833714,FALSE +"H1975","Pearson.est","progesterone receptor agonist",-0.42607,-1.08,0.351,1172,0.606,"nomegestrol.acetate, dienogest, norethindrone.acetate",0.454692883534176,0.217527375833714,FALSE +"H1975","Pearson.est","proteasome inhibitor",-0.38054,-0.965,0.486,905,0.721,"carfilzomib, oprozomib, ixazomib.citrate, delanzomib, ONX.0914",0.313363730737707,0.142064735280571,FALSE +"H1975","Pearson.est","protein synthesis inhibitor",0.35735,0.946,0.502,394,0.754,"tedizolid.phosphate, florfenicol, chloramphenicol.palmitate, bruceantin, harringtonine, methacycline, brefeldin.a, cycloheximide, thiostrepton, clofoctol, azomycin..2.nitroimidazole.",0.299296282854981,0.122628654130226,FALSE +"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.39744,1.02,0.401,209,0.695,"mubritinib, CP.724714, BMS.599626",0.396855627379818,0.158015195409886,FALSE +"H1975","Pearson.est","RAF inhibitor",0.43502,1.11,0.327,278,0.747,"sorafenib, SB.590885, dabrafenib, regorafenib, RAF265",0.485452247339714,0.126679398184601,FALSE +"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.59744,1.56,0.0778,343,0.506,"sorafenib, regorafenib, apatinib, sunitinib",1.10902040301031,0.295849483160201,FALSE +"H1975","Pearson.est","retinoid receptor agonist",0.36177,0.909,0.541,5,0.771,"adarotene",0.266802734893431,0.112945621949043,FALSE +"H1975","Pearson.est","ribonucleotide reductase inhibitor",-0.5592,-1.41,0.14,1145,0.481,"triapine, hydroxyurea, LY2334737, gemcitabine, cladribine, fludarabine, clofarabine",0.853871964321762,0.317854923626168,FALSE +"H1975","Pearson.est","serotonin receptor agonist",0.84011,2.2,0,195,0.0183,"aripiprazole, ipsapirone, NAN.190, zolmitriptan, pardoprunox",Inf,1.73754891026957,TRUE +"H1975","Pearson.est","serotonin receptor antagonist",0.60067,1.54,0.0762,132,0.472,"aripiprazole, ziprasidone, SB.200646, sertindole",1.1180450286604,0.326058001365912,FALSE +"H1975","Pearson.est","sodium channel blocker",-0.35182,-0.899,0.567,969,0.757,"benzethonium, mepivacaine, A.803467, cibenzoline, quinidine, oxcarbazepine",0.246416941107093,0.120904120499927,FALSE +"H1975","Pearson.est","src inhibitor",-0.45592,-1.16,0.297,864,0.583,"dasatinib, KX2.391, masitinib, PP.1, PP.2, bosutinib",0.527243550682788,0.234331445240986,FALSE +"H1975","Pearson.est","sterol demethylase inhibitor",0.36098,0.924,0.534,187,0.768,"posaconazole, sulconazole",0.272458742971444,0.114638779968488,FALSE +"H1975","Pearson.est","TGF beta receptor inhibitor",0.72132,1.85,0.00839,348,0.317,"SB.525334, adaprev, SB.431542, repsox",2.0762380391713,0.498940737782249,FALSE +"H1975","Pearson.est","thymidylate synthase inhibitor",-0.48086,-1.22,0.239,1433,0.514,"doxifluridine",0.621602099051862,0.289036881004724,FALSE +"H1975","Pearson.est","topoisomerase inhibitor",-0.7243,-1.85,0.0133,1200,0.191,"doxorubicin, epirubicin, amsacrine, etoposide.phosphate, TAS.103, amonafide, voreloxin, mitoxantrone, rubitecan, daunorubicin, teniposide, genz.644282, licochalcone.a, irinotecan, etoposide, exatecan.mesylate",1.87614835903291,0.718966632752272,TRUE +"H1975","Pearson.est","tubulin polymerization inhibitor",-0.48046,-1.24,0.229,1082,0.51,"dolastatin.10, combretastatin.A.4, docetaxel, epothilone.b, paclitaxel, parbendazole, CYT.997, oxibendazole, fenbendazole, nocodazole, BNC105, epothilone.d",0.640164517660112,0.292429823902064,FALSE +"H1975","Pearson.est","tyrosine kinase inhibitor",0.23099,0.601,0.916,382,0.921,"sorafenib, mubritinib, CP.724714, BMS.599626, regorafenib, apatinib, sunitinib, tivantinib",0.0381045263321496,0.0357403698031511,FALSE +"H1975","Pearson.est","VEGFR inhibitor",0.4226,1.1,0.334,532,0.693,"sorafenib, ENMD.2076, dovitinib, lenvatinib, OSI.930, nintedanib, tivozanib, BMS.690514, regorafenib, RAF265, sunitinib, linifanib, AEE788, semaxanib, axitinib, pazopanib, motesanib, TG.100572, foretinib, golvatinib, cediranib",0.476253533188435,0.159266765388193,FALSE +"H1975","Pearson.est","vitamin D receptor agonist",0.42613,1.1,0.324,316,0.693,"maxacalcitol, tacalcitol, ercalcitriol, alfacalcidol",0.489454989793388,0.159266765388193,FALSE +"H1648","Pearson.est","EGFR inhibitor",-0.70678,-1.86,0.0106,1278,0.27,"rociletinib, AST.1306, PD.168393, lapatinib, OSI.420, BMS.690514, CP.724714, tyrphostin.AG.1478, vandetanib, BIBU.1361, BIBX.1382, PD.153035, neratinib, XL.647, osimertinib, poziotinib, AZD8931, afatinib, canertinib, pelitinib, dacomitinib, icotinib, gefitinib, erlotinib, WZ8040",1.97469413473523,0.568636235841013,FALSE +"H1648","Pearson.est","Abl kinase inhibitor",-0.14136,-0.381,1,203,0.999,"flumatinib, nilotinib, GZD824, KW.2449, tozasertib, metatinib, ponatinib, bafetinib, dasatinib, ZM.306416, bosutinib, imatinib",0,0.000434511774017692,FALSE +"H1648","Pearson.est","acetylcholine receptor agonist",0.77136,1.96,0.00321,223,0.0484,"tremorine, xanomeline, oxiracetam, pilocarpine",2.49349496759513,1.31515463835559,TRUE +"H1648","Pearson.est","acetylcholine receptor antagonist",-0.5334,-1.47,0.104,1135,0.764,"diphemanil, darifenacin, dicycloverine",0.98296666070122,0.11690664142431,FALSE +"H1648","Pearson.est","adenosine receptor antagonist",-0.38832,-1.07,0.36,1073,1,"SCH.58261, PSB.1115, theophylline, MRS.1220, CGS.15943",0.443697499232713,0,FALSE +"H1648","Pearson.est","adrenergic receptor agonist",-0.49783,-1.35,0.155,1040,0.915,"oxymetazoline, xylazine, terbutaline, metaraminol, clenbuterol, lidamidine, isoetharine, A61603, methyldopa",0.809668301829709,0.0385789059335517,FALSE +"H1648","Pearson.est","adrenergic receptor antagonist",-0.2135,-0.584,0.916,1048,1,"RS.17053, atenolol......, practolol, levobunolol, metoprolol, atenolol...., dronedarone",0.0381045263321496,0,FALSE +"H1648","Pearson.est","AKT inhibitor",-0.38786,-1.05,0.361,1175,1,"CCT128930, A.674563, uprosertib, triciribine",0.442492798094342,0,FALSE +"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.25046,0.64,0.869,362,0.978,"DMH1, alectinib, SB.505124, crizotinib",0.0609802235513335,0.00966114521239857,FALSE +"H1648","Pearson.est","androgen receptor antagonist",-0.49493,-1.33,0.135,1337,0.811,"cyproterone.acetate, enzalutamide",0.869666231504994,0.090979145788844,FALSE +"H1648","Pearson.est","antioxidant",0.48825,1.22,0.248,44,0.576,"trolox",0.605548319173784,0.239577516576788,FALSE +"H1648","Pearson.est","AP inhibitor",0.60089,1.5,0.081,8,0.501,"idronoxil",1.09151498112135,0.300162274132754,FALSE +"H1648","Pearson.est","ATPase inhibitor",0.50933,1.27,0.192,489,0.662,"k.strophanthidin, oligomycin.a, evodiamine, digoxin, ouabain, digitoxigenin, thonzonium, NMS.873",0.71669877129645,0.1791420105603,FALSE +"H1648","Pearson.est","Aurora kinase inhibitor",0.43411,1.1,0.349,639,0.677,"barasertib, AMG900, CCT137690, danusertib, SNS.314, MK.5108, PHA.680632, alisertib, AT.9283, GSK1070916, KW.2449, PF.03814735, ENMD.2076, barasertib.HQPA, ZM.447439, hesperadin, tozasertib, MK.8745, CCT129202",0.45717457304082,0.169411331314856,FALSE +"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.42972,1.1,0.37,277,0.677,"valnemulin, radezolid",0.431798275933005,0.169411331314856,FALSE +"H1648","Pearson.est","bacterial DNA gyrase inhibitor",-0.29091,-0.81,0.663,1266,1,"trovafloxacin, lomefloxacin",0.178486471595227,0,FALSE +"H1648","Pearson.est","BCL inhibitor",0.23801,0.594,0.922,603,1,"TW.37, ABT.737, gossypol, navitoclax",0.0352690789463706,0,FALSE +"H1648","Pearson.est","Bcr.Abl kinase inhibitor",0.20481,0.512,0.982,369,0.991,"flumatinib, nilotinib, GZD824",0.00788851221305034,0.00392634551472468,FALSE +"H1648","Pearson.est","benzodiazepine receptor agonist",-0.27555,-0.751,0.757,1161,1,"zaleplon, bentazepam, gamma.aminobutyric.acid, lorazepam",0.120904120499927,0,FALSE +"H1648","Pearson.est","bromodomain inhibitor",0.48155,1.22,0.224,479,0.576,"PFI.1, bromosporine, I.BET.762, I.BET151",0.649751981665837,0.239577516576788,FALSE +"H1648","Pearson.est","calcium channel blocker",0.2949,0.752,0.759,17,0.895,"carboxyamidotriazole",0.11975822410452,0.048176964684088,FALSE +"H1648","Pearson.est","CC chemokine receptor antagonist",0.48413,1.24,0.223,582,0.656,"UNBS.5162, ZK811752, SB.225002, MK.0812, PF.04136309",0.651695136951839,0.18309616062434,FALSE +"H1648","Pearson.est","CDK inhibitor",-0.27611,-0.757,0.714,1160,1,"CR8..R., TG.02, dinaciclib, alvocidib, BMS.387032, P276.00, arcyriaflavin.a, indirubin",0.146301788223826,0,FALSE +"H1648","Pearson.est","CHK inhibitor",-0.70877,-1.93,0.005,1116,0.363,"AZD7762, LY2603618, LY2606368, CHIR.124, SCH.900776",2.30102999566398,0.440093374963888,FALSE +"H1648","Pearson.est","cyclooxygenase inhibitor",-0.25091,-0.702,0.828,1305,1,"indoprofen, tryptanthrin, naproxen, FK.3311",0.0819696632151199,0,FALSE +"H1648","Pearson.est","cytochrome P450 inhibitor",0.30854,0.774,0.702,283,0.902,"metyrapone, eplerenone",0.153662887870195,0.0447934624580583,FALSE +"H1648","Pearson.est","DNA alkylating agent",-0.30934,-0.855,0.572,1193,1,"ifosfamide, satraplatin, cisplatin, dacarbazine",0.242603971206976,0,FALSE +"H1648","Pearson.est","DNA inhibitor",0.35842,0.923,0.554,417,0.759,"valrubicin, teroxirone, tirapazamine, metronidazole, chlorambucil, oxaliplatin, primaquine, bendamustine, carboplatin",0.25649023527157,0.11975822410452,FALSE +"H1648","Pearson.est","DNA methyltransferase inhibitor",0.56762,1.41,0.116,201,0.51,"decitabine, disulfiram, RG108",0.935542010773082,0.292429823902064,FALSE +"H1648","Pearson.est","DNA polymerase inhibitor",-0.26494,-0.728,0.82,1021,1,"cidofovir, cephalomannine, menadione, famciclovir",0.0861861476162833,0,FALSE +"H1648","Pearson.est","DNA synthesis inhibitor",0.38339,0.972,0.478,83,0.731,"azodicarbonamide, artesunate, anisomycin",0.320572103387881,0.13608262304214,FALSE +"H1648","Pearson.est","dopamine receptor antagonist",0.38747,0.983,0.476,61,0.733,"thioproperazine, paliperidone, raclopride",0.322393047279507,0.134896025358872,FALSE +"H1648","Pearson.est","estrogen receptor agonist",0.42543,1.07,0.381,200,0.662,"ethinyl.estradiol, estrone",0.419075024324381,0.1791420105603,FALSE +"H1648","Pearson.est","estrogen receptor antagonist",0.42506,1.07,0.377,739,0.662,"raloxifene, danazol, fulvestrant, clomifene, toremifene",0.423658649794207,0.1791420105603,FALSE +"H1648","Pearson.est","FGFR inhibitor",0.48643,1.24,0.222,122,0.656,"regorafenib, dovitinib, nintedanib",0.653647025549361,0.18309616062434,FALSE +"H1648","Pearson.est","FLT3 inhibitor",0.45089,1.12,0.321,169,0.691,"sorafenib, TG.101348, dovitinib, tyrphostin.AG.1296",0.493494967595128,0.160521952625802,FALSE +"H1648","Pearson.est","glucocorticoid receptor agonist",0.27329,0.697,0.818,531,0.931,"prednisolone.hemisuccinate, fluticasone.propionate, triamcinolone, beclomethasone.dipropionate, rimexolone, dexamethasone.acetate, prednisolone, deflazacort, ciclesonide, methylprednisolone",0.087246696328677,0.0310503190186574,FALSE +"H1648","Pearson.est","glutamate receptor antagonist",-0.2706,-0.757,0.743,1059,1,"JNJ.16259685, CGP.37849, LY456236, SIB.1757, CPP, kynurenic.acid, diazooxonorleucine",0.129011186239425,0,FALSE +"H1648","Pearson.est","glycogen synthase kinase inhibitor",-0.3309,-0.886,0.576,1320,1,"GSK.3.inhibitor.IX, indirubin",0.239577516576788,0,FALSE +"H1648","Pearson.est","growth factor receptor inhibitor",0.5774,1.46,0.0898,318,0.544,"danusertib, PHA.848125, GSK1838705A",1.0467236633327,0.26440110030182,FALSE +"H1648","Pearson.est","HCV inhibitor",0.57963,1.44,0.11,72,0.536,"narlaprevir, mericitabine",0.958607314841775,0.27083521030723,FALSE +"H1648","Pearson.est","HDAC inhibitor",-0.31742,-0.83,0.604,1158,1,"M.344, nexturastat.a, SB.939, romidepsin, mocetinostat, tacedinaline, JNJ.26481585",0.218963061378868,0,FALSE +"H1648","Pearson.est","histamine receptor antagonist",-0.28731,-0.778,0.708,1447,1,"chloropyramine",0.149966742310231,0,FALSE +"H1648","Pearson.est","HMGCR inhibitor",0.78985,1.99,0.00162,254,0.0535,"atorvastatin, fluvastatin, pitavastatin, lovastatin, mevastatin",2.79048498545737,1.27164621797877,TRUE +"H1648","Pearson.est","HSP inhibitor",0.48607,1.23,0.245,377,0.612,"SNX.2112, NVP.AUY922, BIIB021, ganetespib, PU.H71, NMS.E973, tanespimycin",0.610833915635468,0.213248577854439,FALSE +"H1648","Pearson.est","JAK inhibitor",0.31079,0.787,0.719,71,0.903,"TG.101348, AZD1480, AZ960",0.143271109617117,0.0443122496864942,FALSE +"H1648","Pearson.est","KIT inhibitor",0.46892,1.18,0.269,41,0.598,"sorafenib, masitinib, regorafenib",0.570247719997592,0.223298816011589,FALSE +"H1648","Pearson.est","MDM inhibitor",0.41792,1.05,0.382,450,0.655,"AMG.232, idasanutlin, nutlin.3, CGM097",0.417936637088291,0.183758700008217,FALSE +"H1648","Pearson.est","MEK inhibitor",-0.2241,-0.591,0.915,1446,1,"BIX.02188",0.0385789059335517,0,FALSE +"H1648","Pearson.est","MET inhibitor",0.30164,0.768,0.728,94,0.891,"LY2801653",0.137868620686963,0.0501222959631252,FALSE +"H1648","Pearson.est","microtubule inhibitor",0.56219,1.43,0.118,321,0.511,"D.64131, cabazitaxel, secnidazole, vinblastine, podophyllotoxin, vinflunine",0.928117992693875,0.291579099865287,FALSE +"H1648","Pearson.est","mTOR inhibitor",0.18397,0.464,0.981,133,0.988,"ku.0063794, voxtalisib, AZD2014",0.0083309926200515,0.00524305541237188,FALSE +"H1648","Pearson.est","NFkB pathway inhibitor",-0.30433,-0.819,0.648,1356,1,"bindarit, IKK.2.inhibitor.V",0.188424994129407,0,FALSE +"H1648","Pearson.est","opioid receptor agonist",0.61952,1.58,0.0546,485,0.44,"trimebutine, salvinorin.a, cebranopadol, spiradoline",1.26280735729526,0.356547323513813,FALSE +"H1648","Pearson.est","p38 MAPK inhibitor",-0.3817,-1.02,0.379,1122,1,"TAK.715, CMPD.1, SB.239063",0.421360790031928,0,FALSE +"H1648","Pearson.est","PARP inhibitor",0.50985,1.28,0.202,353,0.682,"niraparib, olaparib, talazoparib, AZD2461",0.694648630553376,0.166215625343521,FALSE +"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.48121,1.23,0.227,274,0.612,"sorafenib, masitinib, regorafenib, dovitinib, nintedanib, axitinib, CP.673451, crenolanib, linifanib",0.643974142806877,0.213248577854439,FALSE +"H1648","Pearson.est","phosphatase inhibitor",-0.21608,-0.583,0.919,1423,1,"mycophenolate.mofetil",0.0366844886138887,0,FALSE +"H1648","Pearson.est","phosphodiesterase inhibitor",-0.26269,-0.699,0.811,1165,0.982,"zardaverine, GSK256066, cilostamide",0.090979145788844,0.00788851221305034,FALSE +"H1648","Pearson.est","PI3K inhibitor",0.21896,0.551,0.953,137,0.99,"ZSTK.474, voxtalisib, GDC.0941",0.0209070993616736,0.00436480540245009,FALSE +"H1648","Pearson.est","PLK inhibitor",0.85982,2.22,0,209,0.00412,"volasertib, NMS.1286937, BI.2536, GW.843682X, GSK461364, rigosertib, HMN.214",Inf,2.38510278396687,TRUE +"H1648","Pearson.est","potassium channel blocker",0.32242,0.814,0.694,253,0.881,"ML133, mepivacaine",0.158640529545145,0.0550240915879521,FALSE +"H1648","Pearson.est","PPAR receptor agonist",-0.36691,-0.999,0.44,1083,1,"pterostilbene, GW.501516, S26948, oleoylethanolamide, clofibrate",0.356547323513813,0,FALSE +"H1648","Pearson.est","progesterone receptor agonist",0.34053,0.859,0.615,503,0.85,"norethindrone, tanaproget, melengestrol.acetate, danazol, nomegestrol.acetate, norgestrel",0.211124884224583,0.0705810742857073,FALSE +"H1648","Pearson.est","proteasome inhibitor",-0.17014,-0.456,0.989,245,1,"delanzomib, ixazomib, ONX.0914, bortezomib, oprozomib, MG.132, carfilzomib, ixazomib.citrate",0.0048037084028206,0,FALSE +"H1648","Pearson.est","protein synthesis inhibitor",0.47027,1.21,0.235,382,0.567,"anguidine, thiostrepton, cycloheximide, mercaptopurine, harringtonine, bruceantin, methacycline, homoharringtonine",0.628932137728264,0.246416941107093,FALSE +"H1648","Pearson.est","protein tyrosine kinase inhibitor",0.37731,0.956,0.503,6,0.739,"mubritinib",0.298432014944073,0.131355561605174,FALSE +"H1648","Pearson.est","RAF inhibitor",0.42166,1.05,0.409,41,0.655,"sorafenib, regorafenib",0.388276691992658,0.183758700008217,FALSE +"H1648","Pearson.est","RET tyrosine kinase inhibitor",0.62093,1.58,0.0447,41,0.44,"sorafenib, regorafenib",1.34969247686806,0.356547323513813,FALSE +"H1648","Pearson.est","retinoid receptor agonist",-0.41621,-1.14,0.28,1308,1,"adapalene, adarotene, CD.437",0.552841968657781,0,FALSE +"H1648","Pearson.est","ribonucleotide reductase inhibitor",0.61545,1.54,0.0696,513,0.47,"cladribine, triapine, fludarabine.phosphate, cytarabine, clofarabine, pentostatin, fludarabine, gemcitabine",1.15739076038944,0.327902142064283,FALSE +"H1648","Pearson.est","serotonin receptor agonist",0.32828,0.84,0.664,436,0.86,"zolmitriptan, SR.57227A, pardoprunox",0.177831920631982,0.0655015487564323,FALSE +"H1648","Pearson.est","serotonin receptor antagonist",0.41142,1.01,0.445,33,0.704,"SB.200646, paliperidone",0.351639989019068,0.152427340857888,FALSE +"H1648","Pearson.est","sodium channel blocker",-0.3497,-0.957,0.463,1352,1,"benzethonium, lappaconite",0.334419008982047,0,FALSE +"H1648","Pearson.est","src inhibitor",-0.43688,-1.22,0.241,1388,0.987,"PP.1, saracatinib, PP.2",0.617982957425132,0.00568284733036327,FALSE +"H1648","Pearson.est","sterol demethylase inhibitor",0.51841,1.32,0.151,490,0.629,"lanoconazole, chlormidazole, sulconazole, ketoconazole, posaconazole",0.821023052706831,0.201349354554731,FALSE +"H1648","Pearson.est","TGF beta receptor inhibitor",0.42659,1.07,0.378,126,0.662,"adaprev",0.422508200162775,0.1791420105603,FALSE +"H1648","Pearson.est","thymidylate synthase inhibitor",0.22798,0.576,0.924,660,0.993,"trifluridine, capecitabine, carmofur, raltitrexed, ftorafur",0.0343280287798933,0.00305075150461883,FALSE +"H1648","Pearson.est","topoisomerase inhibitor",0.68149,1.71,0.0224,248,0.292,"mitoxantrone, idarubicin, TAS.103, voreloxin, etoposide.phosphate, valrubicin, amonafide, amsacrine, daunorubicin, nemorubicin, teniposide, doxorubicin, SN.38, topotecan",1.64975198166584,0.534617148551582,FALSE +"H1648","Pearson.est","tubulin polymerization inhibitor",0.55276,1.38,0.129,439,0.535,"docetaxel, epothilone.b, verubulin, vindesine, taltobulin, mebendazole, vinblastine, dolastatin.10, podophyllotoxin, BNC105, KX2.391, CYT.997, flubendazole, vincristine, plinabulin, fosbretabulin, combretastatin.A.4",0.889410289700751,0.271646217978772,FALSE +"H1648","Pearson.est","tyrosine kinase inhibitor",0.36606,0.926,0.535,145,0.774,"mubritinib, sorafenib, regorafenib, hypericin",0.271646217978772,0.111259039317107,FALSE +"H1648","Pearson.est","VEGFR inhibitor",0.28211,0.713,0.806,151,0.929,"sorafenib, regorafenib, tivozanib, dovitinib, nintedanib, foretinib, axitinib",0.0936649581949093,0.0319842860063582,FALSE +"H1648","Pearson.est","vitamin D receptor agonist",-0.62747,-1.67,0.0259,1331,0.472,"calcitriol, maxacalcitol, paricalcitol",1.58670023591875,0.326058001365912,FALSE +"H2126","Pearson.est","EGFR inhibitor",-0.55917,-1.43,0.11,1052,0.564,"AZD8931, dacomitinib, canertinib, tucatinib, TAK.285, rociletinib, osimertinib, OSI.420, pelitinib, poziotinib, BIBX.1382, afatinib, XL.647, WZ.3146, tyrphostin.AG.1478, AEE788, gefitinib, neratinib, PD.168393, BMS.599626, vandetanib, icotinib, GW.583340, AST.1306, BIBU.1361, WZ8040, CP.724714, erlotinib, PD.153035",0.958607314841775,0.248720896016658,FALSE +"H2126","Pearson.est","Abl kinase inhibitor",0.25223,0.668,0.856,354,0.945,"ponatinib, KW.2449, nilotinib, GZD824, flumatinib",0.0675262353228468,0.0245681914907371,FALSE +"H2126","Pearson.est","acetylcholine receptor agonist",0.57584,1.57,0.0615,57,0.36,"tremorine, xanomeline",1.21112488422458,0.443697499232713,FALSE +"H2126","Pearson.est","acetylcholine receptor antagonist",-0.72428,-1.81,0.00862,1297,0.174,"dicycloverine, darifenacin, diphemanil",2.06449273417529,0.7594507517174,TRUE +"H2126","Pearson.est","adenosine receptor antagonist",-0.7338,-1.82,0.00836,1141,0.48,"theophylline, istradefylline, SCH.58261, MRS.1220, CGS.15943",2.07779372256098,0.318758762624413,FALSE +"H2126","Pearson.est","adrenergic receptor agonist",-0.43238,-1.08,0.394,1080,0.742,"lidamidine, isoxsuprine, metaraminol, isoetharine, xylazine, A61603",0.404503778174426,0.129596094720973,FALSE +"H2126","Pearson.est","adrenergic receptor antagonist",-0.33477,-0.843,0.633,982,0.934,"idazoxan, prazosin, metoprolol, imiloxan, atenolol...., naftidrofuryl, pindolol, dronedarone",0.198596289982645,0.0296531237699066,FALSE +"H2126","Pearson.est","AKT inhibitor",-0.26764,-0.68,0.822,1258,0.932,"palomid.529, A.674563",0.0851281824599496,0.0305840876460186,FALSE +"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.34399,0.909,0.554,27,0.757,"DMH1, alectinib",0.25649023527157,0.120904120499927,FALSE +"H2126","Pearson.est","androgen receptor antagonist",-0.67637,-1.67,0.0317,1175,0.272,"enzalutamide, flutamide, cyproterone.acetate",1.49894073778225,0.565431095965801,FALSE +"H2126","Pearson.est","antioxidant",-0.31797,-0.797,0.69,1324,0.954,"taurine",0.161150909262745,0.0204516252959049,FALSE +"H2126","Pearson.est","AP inhibitor",-0.46295,-1.14,0.298,1290,0.736,"birinapant, tanshinone.i",0.525783735923745,0.133122185662501,FALSE +"H2126","Pearson.est","ATPase inhibitor",0.61586,1.65,0.0469,260,0.415,"ouabain, k.strophanthidin, digitoxigenin, omeprazole, oligomycin.a, NMS.873, evodiamine, thonzonium",1.32882715728492,0.381951903287907,FALSE +"H2126","Pearson.est","Aurora kinase inhibitor",0.31416,0.85,0.642,480,0.789,"CCT137690, CCT129202, KW.2449, barasertib, ENMD.2076, aurora.a.inhibitor.i, AMG900, GSK1070916, alisertib, SNS.314, MK.8745, PF.03814735, barasertib.HQPA",0.192464971931147,0.10292299679058,FALSE +"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.19853,0.52,0.981,298,0.972,"valnemulin, radezolid",0.0083309926200515,0.0123337350737254,FALSE +"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.3641,1.01,0.418,67,0.676,"novobiocin, sparfloxacin",0.378823718224965,0.170053304058364,FALSE +"H2126","Pearson.est","BCL inhibitor",0.30417,0.824,0.661,155,0.809,"navitoclax, ABT.737",0.17979854051436,0.0920514783877277,FALSE +"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.19637,0.53,0.966,354,0.991,"ponatinib, nilotinib, GZD824, flumatinib",0.0150228735845067,0.00392634551472468,FALSE +"H2126","Pearson.est","benzodiazepine receptor agonist",-0.31008,-0.792,0.683,989,0.931,"CGS.20625, indiplon, temazepam, gamma.aminobutyric.acid, lorazepam",0.165579296318467,0.0310503190186574,FALSE +"H2126","Pearson.est","bromodomain inhibitor",0.68352,1.8,0.02,424,0.472,"I.BET151, PFI.1, I.BET.762, bromosporine",1.69897000433602,0.326058001365912,FALSE +"H2126","Pearson.est","calcium channel blocker",-0.33728,-0.848,0.631,1383,0.958,"mibefradil, SKF.96365",0.199970640755866,0.0186344909214556,FALSE +"H2126","Pearson.est","CC chemokine receptor antagonist",0.60818,1.57,0.0884,231,0.36,"ZK811752, UNBS.5162, SB.225002",1.05354773498693,0.443697499232713,FALSE +"H2126","Pearson.est","CDK inhibitor",-0.35484,-0.901,0.535,984,0.926,"NU6027, JNJ.7706621, kenpaullone, TG.02, alvocidib, dinaciclib, BMS.387032, CR8..R., indirubin, arcyriaflavin.a",0.271646217978772,0.0333890133180656,FALSE +"H2126","Pearson.est","CHK inhibitor",-0.61936,-1.59,0.0439,1094,0.359,"LY2603618, SCH.900776, AZD7762, LY2606368, CHIR.124",1.35753547975788,0.444905551421681,FALSE +"H2126","Pearson.est","cyclooxygenase inhibitor",-0.35878,-0.911,0.55,1287,0.943,"phenylbutazone, naproxen, FR.122047, FK.3311",0.259637310505756,0.0254883072626717,FALSE +"H2126","Pearson.est","cytochrome P450 inhibitor",-0.27412,-0.688,0.815,395,0.947,"cobicistat, PF.4981517, metyrapone, clotrimazole, eplerenone, itraconazole, morin",0.0888423912600234,0.0236500209967266,FALSE +"H2126","Pearson.est","DNA alkylating agent",-0.25448,-0.63,0.889,1152,0.914,"streptozotocin, satraplatin, cisplatin, dacarbazine",0.0510982390297863,0.0390538042661686,FALSE +"H2126","Pearson.est","DNA inhibitor",0.31703,0.857,0.604,345,0.801,"carmustine, chlorambucil, oxaliplatin, teroxirone, valrubicin, carboplatin, melphalan",0.218963061378868,0.0963674839157623,FALSE +"H2126","Pearson.est","DNA methyltransferase inhibitor",0.57039,1.53,0.0829,235,0.336,"decitabine, disulfiram",1.08144546944973,0.473660722610156,FALSE +"H2126","Pearson.est","DNA polymerase inhibitor",0.38055,1.03,0.38,124,0.67,"trifluridine, adefovir.dipivoxil",0.42021640338319,0.173925197299174,FALSE +"H2126","Pearson.est","DNA synthesis inhibitor",-0.44043,-1.1,0.352,1439,0.739,"estramustine.phosphate, altretamine",0.453457336521869,0.131355561605174,FALSE +"H2126","Pearson.est","dopamine receptor antagonist",-0.39651,-0.999,0.46,1354,0.795,"clebopride, remoxipride, nemonapride, piperacetazine",0.337242168318426,0.0996328713435297,FALSE +"H2126","Pearson.est","estrogen receptor agonist",0.34615,0.921,0.521,59,0.787,"ethinyl.estradiol",0.283162276700476,0.104025267640935,FALSE +"H2126","Pearson.est","estrogen receptor antagonist",-0.33609,-0.867,0.598,838,0.957,"tamoxifen, danazol, clomifene, fulvestrant",0.223298816011589,0.0190880622231565,FALSE +"H2126","Pearson.est","FGFR inhibitor",0.48616,1.29,0.163,180,0.487,"erdafitinib, regorafenib, nintedanib, dovitinib",0.787812395596042,0.312471038785366,FALSE +"H2126","Pearson.est","FLT3 inhibitor",0.43441,1.17,0.273,239,0.51,"sorafenib, tyrphostin.AG.1296, ponatinib, KW.2449, dovitinib, TG.101348, ENMD.2076",0.563837352959244,0.292429823902064,FALSE +"H2126","Pearson.est","glucocorticoid receptor agonist",-0.23779,-0.602,0.922,1103,0.917,"fluorometholone, betamethasone, methylprednisolone, rimexolone, flumethasone, hydrocortisone",0.0352690789463706,0.0376306643299789,FALSE +"H2126","Pearson.est","glutamate receptor antagonist",-0.43661,-1.1,0.333,1056,0.739,"ACDPP, kynurenic.acid, tiletamine, diazooxonorleucine, CPP, latrepirdine, LY456236, JNJ.16259685",0.47755576649368,0.131355561605174,FALSE +"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.31524,-0.802,0.713,1015,0.977,"kenpaullone, LY2090314, GSK.3.inhibitor.IX, indirubin",0.146910470148134,0.0101054362812269,FALSE +"H2126","Pearson.est","growth factor receptor inhibitor",0.45669,1.2,0.252,185,0.513,"GSK1838705A, PHA.848125",0.598599459218456,0.289882634888184,FALSE +"H2126","Pearson.est","HCV inhibitor",0.43039,1.18,0.273,114,0.519,"narlaprevir, mericitabine",0.563837352959244,0.284832642151542,FALSE +"H2126","Pearson.est","HDAC inhibitor",-0.61559,-1.54,0.0871,1214,0.398,"PCI.24781, scriptaid, panobinostat, entinostat, nexturastat.a, mocetinostat, M.344, romidepsin, SB.939, JNJ.26481585, tacedinaline",1.05998184499234,0.400116927926312,FALSE +"H2126","Pearson.est","histamine receptor antagonist",-0.44426,-1.15,0.297,1241,0.758,"zolantidine, BF2.649, lafutidine, famotidine, ranitidine, chloropyramine",0.527243550682788,0.120330794367946,FALSE +"H2126","Pearson.est","HMGCR inhibitor",0.64066,1.69,0.0536,388,0.438,"atorvastatin, fluvastatin, mevastatin",1.27083521030723,0.3585258894959,FALSE +"H2126","Pearson.est","HSP inhibitor",0.49137,1.28,0.207,182,0.446,"BIIB021, NMS.E973, SNX.2112, SNX.5422, PU.H71, NVP.AUY922",0.684029654543082,0.350665141287858,FALSE +"H2126","Pearson.est","JAK inhibitor",-0.24966,-0.637,0.901,1377,0.93,"CEP.33779, pacritinib",0.045275209020937,0.0315170514460649,FALSE +"H2126","Pearson.est","KIT inhibitor",0.52204,1.39,0.137,76,0.399,"sorafenib, masitinib, OSI.930, regorafenib",0.863279432843593,0.399027104313252,FALSE +"H2126","Pearson.est","MDM inhibitor",-0.53988,-1.41,0.121,1415,0.545,"RITA",0.91721462968355,0.263603497723358,FALSE +"H2126","Pearson.est","MEK inhibitor",0.21669,0.572,0.942,436,0.991,"PD.318088, PD.0325901, AZD8330, Ro.4987655, AS.703026, MEK162, trametinib, cobimetinib, U.0126",0.0259490972071227,0.00392634551472468,FALSE +"H2126","Pearson.est","MET inhibitor",-0.5142,-1.32,0.168,1198,0.577,"PHA.665752, NVP.BVU972, PF.04217903, INC.280",0.774690718274137,0.238824186844269,FALSE +"H2126","Pearson.est","microtubule inhibitor",-0.29198,-0.734,0.777,1178,0.966,"cytochalasin.b, colchicine, estramustine.phosphate",0.109578981199086,0.0150228735845067,FALSE +"H2126","Pearson.est","mTOR inhibitor",-0.41914,-1.05,0.39,863,0.73,"LY303511, torin.2, NVP.BEZ235, MLN0128, torin.1, GSK2126458, sirolimus, everolimus, SB.2343, WYE.125132, AZD8055, PKI.179, PF.05212384, GDC.0980, PI.103, temsirolimus, PP242, palomid.529, LY3023414, deforolimus",0.408935392973501,0.136677139879544,FALSE +"H2126","Pearson.est","NFkB pathway inhibitor",-0.2832,-0.718,0.809,1024,0.961,"BAY.11.7085, IKK.2.inhibitor.V, bindarit, tyloxapol",0.0920514783877277,0.0172766123314547,FALSE +"H2126","Pearson.est","opioid receptor agonist",0.37398,1.03,0.39,198,0.67,"trimebutine, spiradoline",0.408935392973501,0.173925197299174,FALSE +"H2126","Pearson.est","p38 MAPK inhibitor",0.30544,0.812,0.671,12,0.804,"talmapimod",0.173277479831008,0.0947439512515487,FALSE +"H2126","Pearson.est","PARP inhibitor",0.57439,1.54,0.0948,410,0.358,"niraparib, olaparib, talazoparib, AZD2461, PJ.34",1.02319166266193,0.446116973356126,FALSE +"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.48043,1.3,0.189,180,0.501,"sorafenib, masitinib, regorafenib, linifanib, ponatinib, axitinib, nintedanib, dovitinib",0.723538195826756,0.300162274132754,FALSE +"H2126","Pearson.est","phosphatase inhibitor",-0.26291,-0.664,0.841,1397,0.925,"mycophenolate.mofetil",0.0752040042020878,0.0338582672609674,FALSE +"H2126","Pearson.est","phosphodiesterase inhibitor",-0.4173,-1.06,0.369,1252,0.745,"EMD.53998, cilostamide, GSK256066",0.43297363384094,0.127843727251707,FALSE +"H2126","Pearson.est","PI3K inhibitor",-0.30872,-0.788,0.725,863,0.909,"LY303511, NVP.BEZ235, PI3K.IN.2, TG.100713, BGT226, GSK2126458, taselisib, alpelisib, YM.201636, SB.2343, PKI.179, CUDC.907, PF.05212384, GDC.0980, PI.103, AZD6482, PI.828, LY3023414, idelalisib",0.139661993429006,0.0414361167780325,FALSE +"H2126","Pearson.est","PLK inhibitor",0.78791,2.05,0.00242,109,0.137,"rigosertib, volasertib, GW.843682X, NMS.1286937",2.61618463401957,0.863279432843593,TRUE +"H2126","Pearson.est","potassium channel blocker",-0.69503,-1.75,0.0221,1140,0.201,"meglitinide, oleoylethanolamide, ibutilide",1.65560772631489,0.696803942579511,TRUE +"H2126","Pearson.est","PPAR receptor agonist",-0.55192,-1.4,0.114,1315,0.511,"oleoylethanolamide, clofibrate, GW.501516",0.943095148663527,0.291579099865287,FALSE +"H2126","Pearson.est","progesterone receptor agonist",0.25427,0.656,0.855,358,0.936,"norethindrone, norgestrel, melengestrol.acetate, tanaproget",0.0680338852718274,0.0287241512618947,FALSE +"H2126","Pearson.est","proteasome inhibitor",0.42485,1.14,0.296,519,0.536,"MG.132, delanzomib, ixazomib, oprozomib, bortezomib, carfilzomib",0.528708288941061,0.27083521030723,FALSE +"H2126","Pearson.est","protein synthesis inhibitor",0.29477,0.79,0.714,393,0.817,"thiostrepton, anguidine, mercaptopurine, tedizolid.phosphate, florfenicol, cycloheximide, harringtonine",0.146301788223826,0.0877779434675845,FALSE +"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.49492,-1.25,0.198,1330,0.634,"BMS.599626, CP.724714",0.703334809738469,0.197910742118267,FALSE +"H2126","Pearson.est","RAF inhibitor",0.52649,1.42,0.108,225,0.42,"sorafenib, regorafenib, SB.590885, dabrafenib, RAF265",0.96657624451305,0.3767507096021,FALSE +"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.51763,1.39,0.154,76,0.399,"sorafenib, regorafenib",0.812479279163537,0.399027104313252,FALSE +"H2126","Pearson.est","retinoid receptor agonist",0.5629,1.51,0.0806,177,0.331,"LE.135, tamibarotene, fenretinide",1.09366495819491,0.480172006224281,FALSE +"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.34151,0.913,0.495,160,0.776,"triapine, cladribine",0.305394801066431,0.110138278741812,FALSE +"H2126","Pearson.est","serotonin receptor agonist",-0.70709,-1.81,0.00831,1369,0.174,"NAN.190, aripiprazole",2.08039897621589,0.7594507517174,TRUE +"H2126","Pearson.est","serotonin receptor antagonist",-0.49807,-1.27,0.205,1447,0.638,"aripiprazole",0.688246138944246,0.195179321278838,FALSE +"H2126","Pearson.est","sodium channel blocker",-0.27649,-0.7,0.815,1097,0.959,"triamterene, quinidine, ajmaline, lappaconite",0.0888423912600234,0.0181813928293364,FALSE +"H2126","Pearson.est","src inhibitor",-0.46915,-1.19,0.273,1240,0.716,"bosutinib, PP.2, PP.1",0.563837352959244,0.145086977692144,FALSE +"H2126","Pearson.est","sterol demethylase inhibitor",0.50279,1.28,0.197,164,0.446,"chlormidazole, sulconazole",0.705533773838407,0.350665141287858,FALSE +"H2126","Pearson.est","TGF beta receptor inhibitor",0.45722,1.24,0.22,167,0.48,"SB.431542",0.657577319177794,0.318758762624413,FALSE +"H2126","Pearson.est","thymidylate synthase inhibitor",0.33469,0.923,0.537,133,0.812,"trifluridine, capecitabine",0.270025714300444,0.0904439707588247,FALSE +"H2126","Pearson.est","topoisomerase inhibitor",0.62645,1.69,0.0238,289,0.438,"etoposide.phosphate, idarubicin, topotecan, TAS.103, voreloxin, doxorubicin, nemorubicin, mitoxantrone, SN.38, exatecan.mesylate, daunorubicin, valrubicin, amonafide, teniposide",1.62342304294349,0.3585258894959,FALSE +"H2126","Pearson.est","tubulin polymerization inhibitor",0.58268,1.57,0.0678,325,0.36,"verubulin, vinblastine, docetaxel, BNC105, vindesine, podophyllotoxin, taltobulin, fosbretabulin, albendazole, combretastatin.A.4, dolastatin.10, plinabulin, flubendazole, mebendazole, vincristine, indibulin",1.16877030613294,0.443697499232713,FALSE +"H2126","Pearson.est","tyrosine kinase inhibitor",0.26878,0.712,0.788,219,0.912,"sorafenib, regorafenib, hypericin, tivantinib, UNC2250, mubritinib",0.103473782510445,0.0400051616715838,FALSE +"H2126","Pearson.est","VEGFR inhibitor",0.32813,0.879,0.585,276,0.787,"sorafenib, tivozanib, OSI.930, regorafenib, linifanib, axitinib, nintedanib, dovitinib, RAF265, ENMD.2076, MGCD.265",0.23284413391782,0.104025267640935,FALSE +"H2126","Pearson.est","vitamin D receptor agonist",-0.54259,-1.35,0.137,1001,0.565,"tacalcitol, calcitriol, maxacalcitol, paricalcitol",0.863279432843593,0.247951552180562,FALSE +"H520","Pearson.est","EGFR inhibitor",-0.40163,-1.01,0.436,1055,0.872,"PD.168393, WZ.4002, dacomitinib, dovitinib, brigatinib, salvianolic.acid.B, AZD8931, gefitinib, TAK.285, ARRY.334543, XL.647, lapatinib, CP.724714, tucatinib, AEE788, rociletinib, neratinib, GW.583340",0.360513510731414,0.0594835150674328,FALSE +"H520","Pearson.est","Abl kinase inhibitor",-0.46688,-1.16,0.295,944,0.899,"dasatinib, bosutinib, imatinib, GZD824, flumatinib, metatinib, ponatinib, bafetinib, nilotinib",0.530177984021837,0.0462403082667712,FALSE +"H520","Pearson.est","acetylcholine receptor agonist",0.53333,1.39,0.125,198,0.444,"nicotine, nefiracetam",0.903089986991944,0.35261702988538,FALSE +"H520","Pearson.est","acetylcholine receptor antagonist",-0.58687,-1.46,0.0856,1051,0.807,"methscopolamine, hyoscyamine, diphemanil",1.06752623532285,0.0931264652779296,FALSE +"H520","Pearson.est","adenosine receptor antagonist",-0.2068,-0.515,0.96,298,0.973,"istradefylline, MRS.1220, SCH.58261, PSB.1115, sulmazole, CGS.15943, theophylline",0.0177287669604316,0.0118871597316481,FALSE +"H520","Pearson.est","adrenergic receptor agonist",0.27738,0.696,0.823,306,0.937,"oxymetazoline, isoxsuprine, terbutaline, buphenine, clenbuterol, metaraminol",0.0846001647877302,0.0282604091122217,FALSE +"H520","Pearson.est","adrenergic receptor antagonist",-0.4522,-1.15,0.289,1137,0.821,"naftidrofuryl, vincamine, metoprolol, idazoxan, carvedilol, prazosin, practolol, RS.17053, dihydroergocristine",0.539102157243452,0.0856568428805592,FALSE +"H520","Pearson.est","AKT inhibitor",0.51098,1.34,0.173,366,0.402,"MK.2206, palomid.529, GDC.0068, AT7867, AZD5363, ONC201, CCT128930",0.761953896871205,0.39577394691553,FALSE +"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.4083,-1.02,0.413,1016,0.883,"NVP.TAE684, crizotinib, AZD3463, brigatinib, DMH1, AP26113, CEP.37440",0.384049948343599,0.0540392964224314,FALSE +"H520","Pearson.est","androgen receptor antagonist",0.51744,1.34,0.161,121,0.402,"RU.58841, nilutamide",0.79317412396815,0.39577394691553,FALSE +"H520","Pearson.est","antioxidant",0.54537,1.42,0.102,80,0.437,"mesna, benfotiamine",0.991399828238082,0.359518563029578,FALSE +"H520","Pearson.est","AP inhibitor",0.65751,1.69,0.0271,66,0.211,"birinapant, GDC.0152",1.56703070912559,0.675717544702307,TRUE +"H520","Pearson.est","ATPase inhibitor",-0.21253,-0.523,0.963,1075,0.989,"oligomycin.a, digoxin, digitoxin, evodiamine",0.0163737128754655,0.0048037084028206,FALSE +"H520","Pearson.est","Aurora kinase inhibitor",-0.27819,-0.699,0.833,1054,0.955,"MK.5108, barasertib.HQPA, SNS.314, TAK.901, CCT137690, AT.9283, CYC116, danusertib, PHA.680632",0.0793549985932124,0.0199966284162537,FALSE +"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.31082,-0.804,0.692,935,0.958,"valnemulin, azithromycin, josamycin, dirithromycin",0.159893905543242,0.0186344909214556,FALSE +"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.7398,1.91,0.00665,45,0.108,"finafloxacin, novobiocin, trovafloxacin",2.1771783546969,0.96657624451305,TRUE +"H520","Pearson.est","BCL inhibitor",0.43576,1.11,0.304,137,0.505,"venetoclax, oridonin, HA14.1",0.517126416391246,0.296708621881339,FALSE +"H520","Pearson.est","Bcr.Abl kinase inhibitor",-0.63063,-1.53,0.0693,944,0.689,"dasatinib, bosutinib, imatinib, GZD824, flumatinib, metatinib, ponatinib, bafetinib, nilotinib",1.15926676538819,0.161780778092374,FALSE +"H520","Pearson.est","benzodiazepine receptor agonist",-0.27515,-0.7,0.829,1202,0.976,"ZK.93423, bentazepam, indiplon",0.0814454694497265,0.0105501823333082,FALSE +"H520","Pearson.est","bromodomain inhibitor",-0.69606,-1.72,0.0216,1119,0.533,"OTX015, bromosporine, I.BET.762, PFI.1",1.66554624884907,0.273272790973428,FALSE +"H520","Pearson.est","calcium channel blocker",0.41509,1.09,0.36,209,0.51,"cinnarazine, efonidipine.monoethanolate, SR.33805, pranidipine",0.443697499232713,0.292429823902064,FALSE +"H520","Pearson.est","CC chemokine receptor antagonist",-0.35896,-0.877,0.587,1406,0.934,"UNBS.5162",0.231361898752386,0.0296531237699066,FALSE +"H520","Pearson.est","CDK inhibitor",-0.31589,-0.777,0.73,1019,0.978,"abemaciclib, CR8..R., indisulam, aminopurvalanol.a, PHA.848125, arcyriaflavin.a, dinaciclib, AT.7519, BMS.387032",0.136677139879544,0.00966114521239857,FALSE +"H520","Pearson.est","CHK inhibitor",-0.46846,-1.17,0.246,1313,0.931,"SB.218078, PF.477736",0.609064892896621,0.0310503190186574,FALSE +"H520","Pearson.est","cyclooxygenase inhibitor",0.22173,0.575,0.958,319,1,"metoxibutropate, FR.122047, phenylbutazone, indoprofen, aspirin, amfenac, suxibuzone, curcumin, acetylsalicylsalicylic.acid",0.0186344909214556,0,FALSE +"H520","Pearson.est","cytochrome P450 inhibitor",-0.23838,-0.587,0.927,972,0.99,"morin, eplerenone, metyrapone",0.0329202658555029,0.00436480540245009,FALSE +"H520","Pearson.est","DNA alkylating agent",-0.46172,-1.17,0.284,1010,0.931,"satraplatin, temozolomide, melphalan, ifosfamide, dacarbazine, dianhydrogalactitol, mitomycin.c",0.546681659952962,0.0310503190186574,FALSE +"H520","Pearson.est","DNA inhibitor",-0.26839,-0.678,0.836,969,0.96,"oxaliplatin, valrubicin, pibenzimol, melphalan, teroxirone, primaquine, mechlorethamine, bendamustine",0.0777937225609836,0.0177287669604316,FALSE +"H520","Pearson.est","DNA methyltransferase inhibitor",0.50627,1.3,0.184,146,0.427,"azacitidine, decitabine",0.735182176990464,0.369572124974976,FALSE +"H520","Pearson.est","DNA polymerase inhibitor",0.59836,1.54,0.0888,513,0.313,"famciclovir, cephalomannine, adefovir.dipivoxil, trifluridine, cidofovir, foscarnet, menadione",1.0515870342214,0.504455662453552,FALSE +"H520","Pearson.est","DNA synthesis inhibitor",0.20012,0.517,0.969,201,0.974,"CB.10.277, capecitabine, altretamine",0.0136762229492347,0.0114410431213845,FALSE +"H520","Pearson.est","dopamine receptor antagonist",0.48935,1.27,0.207,322,0.436,"clebopride, acetophenazine, oxiperomide, UH.232...., ziprasidone, domperidone, raclopride, mesoridazine, remoxipride, paliperidone",0.684029654543082,0.360513510731414,FALSE +"H520","Pearson.est","estrogen receptor agonist",-0.28534,-0.701,0.78,1229,0.999,"equol, levonorgestrel",0.10790539730952,0.000434511774017692,FALSE +"H520","Pearson.est","estrogen receptor antagonist",-0.5618,-1.39,0.104,1245,0.728,"toremifene, tamoxifen",0.98296666070122,0.137868620686963,FALSE +"H520","Pearson.est","FGFR inhibitor",-0.54587,-1.37,0.151,1047,0.705,"AZD4547, dovitinib, nintedanib, regorafenib, erdafitinib, lenvatinib",0.821023052706831,0.151810883008601,FALSE +"H520","Pearson.est","FLT3 inhibitor",-0.32392,-0.808,0.668,908,0.978,"ENMD.2076, lestaurtinib, midostaurin, dovitinib, ponatinib, tyrphostin.AG.1296, TG.101348, quizartinib",0.175223537524454,0.00966114521239857,FALSE +"H520","Pearson.est","glucocorticoid receptor agonist",-0.38983,-0.969,0.477,1122,0.893,"flumethasone.pivalate, clobetasol.propionate, methylprednisolone, flumethasone, fluticasone.propionate, halcinonide, triamcinolone.acetonide, fluorometholone, betamethasone, deflazacort",0.321481620959886,0.0491485411114536,FALSE +"H520","Pearson.est","glutamate receptor antagonist",-0.29125,-0.723,0.796,1307,1,"ACDPP, CGP.37849, LY456236",0.0990869322623309,0,FALSE +"H520","Pearson.est","glycogen synthase kinase inhibitor",0.45609,1.17,0.276,303,0.445,"LY2090314, kenpaullone, indirubin, tideglusib",0.559090917934782,0.351639989019068,FALSE +"H520","Pearson.est","growth factor receptor inhibitor",-0.38439,-0.965,0.505,939,0.87,"lestaurtinib, AZD3463, PHA.848125, danusertib",0.296708621881339,0.0604807473813815,FALSE +"H520","Pearson.est","HCV inhibitor",-0.36301,-0.919,0.531,1007,0.877,"narlaprevir, PSI.7976, mericitabine",0.274905478918531,0.0570004066339595,FALSE +"H520","Pearson.est","HDAC inhibitor",0.36545,0.939,0.486,216,0.667,"romidepsin, JNJ.26481585, R306465, RGFP966, tacedinaline, pyroxamide",0.313363730737707,0.175874166083451,FALSE +"H520","Pearson.est","histamine receptor antagonist",0.1996,0.517,0.954,394,0.974,"epinastine, ranitidine, terfenadine, levocetirizine, tecastemizole, famotidine",0.0204516252959049,0.0114410431213845,FALSE +"H520","Pearson.est","HMGCR inhibitor",0.72469,1.88,0.0119,403,0.102,"pitavastatin, fluvastatin, lovastatin, atorvastatin, mevastatin, simvastatin",1.92445303860747,0.991399828238082,TRUE +"H520","Pearson.est","HSP inhibitor",0.5203,1.38,0.126,468,0.415,"BIIB021, PU.H71, SNX.5422, KW.2478, VER.49009, NVP.AUY922, SNX.2112, tanespimycin",0.899629454882437,0.381951903287907,FALSE +"H520","Pearson.est","JAK inhibitor",-0.39686,-0.982,0.479,939,0.897,"lestaurtinib, ruxolitinib, TG.101209, baricitinib, CEP.33779, AT.9283, TG.101348, LY2784544",0.319664486585437,0.0472075569559079,FALSE +"H520","Pearson.est","KIT inhibitor",-0.41813,-1.04,0.405,854,0.916,"sorafenib, cediranib, dasatinib, midostaurin, imatinib, masitinib, regorafenib, pazopanib, lenvatinib",0.392544976785331,0.0381045263321496,FALSE +"H520","Pearson.est","MDM inhibitor",0.71768,1.92,0.00728,213,0.149,"RITA, idasanutlin, serdemetan, nutlin.3",2.13786862068696,0.826813731587726,TRUE +"H520","Pearson.est","MEK inhibitor",0.84218,2.19,0,95,0.0165,"AZD8330, TAK.733, PD.0325901, Ro.4987655, PD.184352, refametinib, AS.703026, cobimetinib, PD.318088, trametinib, MEK162, selumetinib",Inf,1.78251605578609,TRUE +"H520","Pearson.est","MET inhibitor",0.22676,0.588,0.95,413,1,"AMG458, PF.04217903, INC.280",0.0222763947111523,0,FALSE +"H520","Pearson.est","microtubule inhibitor",-0.56865,-1.4,0.141,1352,0.788,"cabazitaxel, D.64131, colchicine",0.85078088734462,0.103473782510445,FALSE +"H520","Pearson.est","mTOR inhibitor",-0.32998,-0.809,0.686,992,1,"torin.1, NVP.BEZ235, SB.2343, AZD8055, PF.05212384, PKI.179, WYE.354, MLN0128, deforolimus, PF.04691502, WYE.125132",0.163675884293248,0,FALSE +"H520","Pearson.est","NFkB pathway inhibitor",0.37023,0.949,0.485,147,0.678,"BAY.11.7085, betulinic.acid",0.314258261397736,0.168770306132937,FALSE +"H520","Pearson.est","opioid receptor agonist",0.69851,1.79,0.0349,308,0.148,"cebranopadol, BW.180C, salvinorin.a, ADL5859",1.45717457304082,0.829738284605043,TRUE +"H520","Pearson.est","p38 MAPK inhibitor",-0.37378,-0.93,0.521,1446,0.883,"talmapimod",0.283162276700476,0.0540392964224314,FALSE +"H520","Pearson.est","PARP inhibitor",-0.26875,-0.671,0.854,387,0.947,"AZD2461, AG.14361, olaparib, talazoparib, endo.IWR.1, E7449, niraparib, PJ.34",0.068542129310995,0.0236500209967266,FALSE +"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.32954,-0.826,0.656,1044,1,"imatinib, dovitinib, masitinib, nintedanib, ponatinib, crenolanib, regorafenib, pazopanib, lenvatinib",0.18309616062434,0,FALSE +"H520","Pearson.est","phosphatase inhibitor",0.27772,0.718,0.806,129,0.938,"bis.maltolato.oxovanadium.IV., alexidine",0.0936649581949093,0.0277971616209356,FALSE +"H520","Pearson.est","phosphodiesterase inhibitor",0.47899,1.25,0.201,369,0.41,"papaverine, anagrelide, zardaverine, EMD.53998",0.696803942579511,0.387216143280265,FALSE +"H520","Pearson.est","PI3K inhibitor",-0.22154,-0.562,0.928,933,0.986,"taselisib, idelalisib, NVP.BEZ235, SB.2343, YM.201636, PIK.75, PI3K.IN.2, BGT226, PF.05212384, PKI.179, PF.04691502, ZSTK.474",0.0324520237811379,0.0061230850587888,FALSE +"H520","Pearson.est","PLK inhibitor",-0.82878,-2.07,0,1251,0.0426,"HMN.214, GW.843682X, BI.2536, volasertib, GSK461364, NMS.1286937",Inf,1.37059040089728,TRUE +"H520","Pearson.est","potassium channel blocker",0.49171,1.26,0.208,44,0.422,"meglitinide",0.681936665037238,0.374687549038326,FALSE +"H520","Pearson.est","PPAR receptor agonist",0.3386,0.84,0.643,75,0.803,"S26948",0.191789027075778,0.095284454721319,FALSE +"H520","Pearson.est","progesterone receptor agonist",-0.25194,-0.621,0.911,901,0.98,"danazol, melengestrol.acetate, nomegestrol.acetate, levonorgestrel",0.0404816230270017,0.00877392430750515,FALSE +"H520","Pearson.est","proteasome inhibitor",0.2875,0.738,0.802,1034,0.941,"ixazomib, ixazomib.citrate, MG.132, ONX.0914, bortezomib, oprozomib, delanzomib, carfilzomib",0.0958256317158365,0.0264103765727431,FALSE +"H520","Pearson.est","protein synthesis inhibitor",-0.55782,-1.35,0.139,1283,0.69,"puromycin, mercaptopurine, clofoctol, bruceantin, harringtonine, anguidine, homoharringtonine",0.856985199745905,0.161150909262745,FALSE +"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.63833,-1.58,0.0597,1115,0.872,"rheochrysidin, mubritinib, tyrphostin.A9, PP.121, CP.724714, AV.412",1.22402566887063,0.0594835150674328,FALSE +"H520","Pearson.est","RAF inhibitor",-0.28813,-0.709,0.842,1342,1,"regorafenib, TAK.632",0.0746879085003505,0,FALSE +"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.37905,-0.947,0.508,1342,0.877,"regorafenib",0.294136287716081,0.0570004066339595,FALSE +"H520","Pearson.est","retinoid receptor agonist",-0.44488,-1.1,0.346,954,0.854,"tamibarotene, AM.580, bexarotene, fenretinide",0.460923901207223,0.068542129310995,FALSE +"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.45984,-1.15,0.311,1272,0.821,"clofarabine, LY2334737, pentostatin",0.507239610973163,0.0856568428805592,FALSE +"H520","Pearson.est","serotonin receptor agonist",0.62914,1.68,0.0392,127,0.191,"aripiprazole, ipsapirone",1.40671393297954,0.718966632752272,TRUE +"H520","Pearson.est","serotonin receptor antagonist",0.47089,1.22,0.261,322,0.425,"aripiprazole, lerisetron, ziprasidone, RS.16566, tropisetron, paliperidone",0.583359492661719,0.371611069949688,FALSE +"H520","Pearson.est","sodium channel blocker",0.38468,1,0.419,76,0.62,"ajmaline, A.803467",0.377785977033705,0.207608310501746,FALSE +"H520","Pearson.est","src inhibitor",-0.45988,-1.18,0.255,944,1,"dasatinib, bosutinib, masitinib, TG.100572, PP.1, KX2.391, saracatinib",0.593459819566045,0,FALSE +"H520","Pearson.est","sterol demethylase inhibitor",-0.63042,-1.57,0.0578,1018,0.695,"terconazole, ketoconazole, posaconazole, lanoconazole, chlormidazole",1.23807216157947,0.158015195409886,FALSE +"H520","Pearson.est","TGF beta receptor inhibitor",0.45354,1.19,0.247,455,0.441,"D.4476, LY2109761, SB.431542, repsox",0.607303046740334,0.355561410532161,FALSE +"H520","Pearson.est","thymidylate synthase inhibitor",-0.44635,-1.12,0.341,1405,0.847,"doxifluridine",0.467245621007502,0.0721165896692931,FALSE +"H520","Pearson.est","topoisomerase inhibitor",-0.57424,-1.43,0.117,1155,0.795,"epirubicin, daunorubicin, idarubicin, licochalcone.a, teniposide, etoposide.phosphate, amonafide, dexrazoxane, etoposide, TAS.103, doxorubicin, exatecan.mesylate, nemorubicin, SN.38, amsacrine, mitoxantrone",0.931814138253838,0.0996328713435297,FALSE +"H520","Pearson.est","tubulin polymerization inhibitor",-0.51161,-1.28,0.175,987,0.821,"nocodazole, plinabulin, taltobulin, vindesine, docetaxel, vincristine, epothilone.b, mebendazole, epothilone.d, dolastatin.10, KX2.391, paclitaxel, ABT.751, oxibendazole, CYT.997, fenbendazole",0.756961951313706,0.0856568428805592,FALSE +"H520","Pearson.est","tyrosine kinase inhibitor",-0.40907,-1.02,0.428,1115,0.883,"rheochrysidin, mubritinib, aminopurvalanol.a, bafetinib, tyrphostin.A9, PP.121, CP.724714, regorafenib, AV.412",0.368556230986828,0.0540392964224314,FALSE +"H520","Pearson.est","VEGFR inhibitor",-0.28601,-0.716,0.804,1102,1,"dovitinib, nintedanib, TG.100572, foretinib, SAR131675, XL.647, AEE788, regorafenib, pazopanib, lenvatinib",0.0947439512515487,0,FALSE +"H520","Pearson.est","vitamin D receptor agonist",-0.42529,-1.04,0.416,1424,0.916,"doxercalciferol",0.380906669373257,0.0381045263321496,FALSE +"H460","Pearson.est","EGFR inhibitor",-0.24982,-0.627,0.895,954,0.95,"brigatinib, CUDC.101, osimertinib, WZ8040, BMS.599626, tyrphostin.AG.1478, CGP.52411, lapatinib, tucatinib, BIBU.1361, neratinib, salvianolic.acid.B, dovitinib, WZ.4002, CP.724714",0.048176964684088,0.0222763947111523,FALSE +"H460","Pearson.est","Abl kinase inhibitor",-0.33433,-0.855,0.636,1266,0.872,"metatinib, nilotinib, imatinib",0.196542884351586,0.0594835150674328,FALSE +"H460","Pearson.est","acetylcholine receptor agonist",-0.41455,-1.05,0.403,1359,0.742,"oxiracetam",0.39469495385889,0.129596094720973,FALSE +"H460","Pearson.est","acetylcholine receptor antagonist",0.74638,2.03,0.00252,210,0.0622,"diphemanil, iododexetimide, hyoscyamine, darifenacin",2.59859945921846,1.20620961530918,TRUE +"H460","Pearson.est","adenosine receptor antagonist",0.40055,1.09,0.329,372,0.571,"CGS.15943, SCH.58261, MRS.1220",0.482804102050026,0.243363891754152,FALSE +"H460","Pearson.est","adrenergic receptor agonist",0.47314,1.29,0.188,398,0.356,"ritodrine, xylazine, methyldopa, A61603, isoxsuprine, clenbuterol, terbutaline, norepinephrine",0.72584215073632,0.448550002027125,FALSE +"H460","Pearson.est","adrenergic receptor antagonist",0.52075,1.41,0.12,104,0.402,"RS.17053, prazosin, atenolol...., metoprolol, practolol",0.920818753952375,0.39577394691553,FALSE +"H460","Pearson.est","AKT inhibitor",-0.34752,-0.87,0.594,1392,0.891,"uprosertib, AT7867",0.226213555018806,0.0501222959631252,FALSE +"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.5019,1.31,0.171,282,0.418,"lorlatinib, NVP.TAE684, GW.788388, AP26113, CEP.37440",0.767003889607846,0.378823718224965,FALSE +"H460","Pearson.est","androgen receptor antagonist",-0.3221,-0.822,0.675,1313,0.907,"RU.58841",0.170696227168975,0.0423927129399047,FALSE +"H460","Pearson.est","antioxidant",-0.66876,-1.71,0.0207,1206,0.415,"trolox, chlorogenic.acid, mesna",1.68402965454308,0.381951903287907,FALSE +"H460","Pearson.est","AP inhibitor",0.34209,0.914,0.548,86,0.675,"tanshinone.i",0.261219441515631,0.170696227168975,FALSE +"H460","Pearson.est","ATPase inhibitor",-0.41793,-1.04,0.394,1101,0.686,"digitoxigenin, ouabain, digitoxin, omeprazole, NMS.873, digoxin",0.404503778174426,0.163675884293248,FALSE +"H460","Pearson.est","Aurora kinase inhibitor",-0.52542,-1.32,0.174,1057,0.638,"MLN.8054, MK.5108, KW.2449, PF.03814735, hesperadin, alisertib, CCT137690, GSK1070916, MK.8745, CCT129202, PHA.680632, ENMD.2076",0.7594507517174,0.195179321278838,FALSE +"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.54785,-1.38,0.144,1336,0.593,"radezolid, tedizolid, azalomycin.b, valnemulin",0.84163750790475,0.226945306635737,FALSE +"H460","Pearson.est","bacterial DNA gyrase inhibitor",0.48833,1.29,0.192,348,0.356,"sparfloxacin, norfloxacin, nadifloxacin, lomefloxacin, trovafloxacin, sarafloxacin",0.71669877129645,0.448550002027125,FALSE +"H460","Pearson.est","BCL inhibitor",-0.60388,-1.53,0.0666,1408,0.445,"TW.37, venetoclax",1.1765257708297,0.351639989019068,FALSE +"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.40925,-1.04,0.411,1266,0.686,"metatinib, nilotinib, imatinib",0.386158178123931,0.163675884293248,FALSE +"H460","Pearson.est","benzodiazepine receptor agonist",0.54037,1.44,0.117,195,0.405,"indiplon, gamma.aminobutyric.acid, piperazine, temazepam, CL.218872, bentazepam",0.931814138253838,0.392544976785331,FALSE +"H460","Pearson.est","bromodomain inhibitor",-0.28704,-0.731,0.783,875,0.943,"JQ1...., bromosporine, I.BET.762",0.106238237942057,0.0254883072626717,FALSE +"H460","Pearson.est","calcium channel blocker",-0.22066,-0.552,0.948,1189,0.972,"SR.33805, mibefradil",0.0231916626619338,0.0123337350737254,FALSE +"H460","Pearson.est","CC chemokine receptor antagonist",-0.453,-1.17,0.271,1268,0.782,"RS.504393, navarixin",0.567030709125594,0.106793246940152,FALSE +"H460","Pearson.est","CDK inhibitor",-0.64369,-1.63,0.0388,1192,0.419,"R547, BMS.387032, abemaciclib, aminopurvalanol.a, TG.02, palbociclib, indirubin, alvocidib, AZD5438, PHA.793887, BMS.265246, ribociclib",1.41116827440579,0.377785977033705,FALSE +"H460","Pearson.est","CHK inhibitor",-0.26436,-0.663,0.877,1008,0.992,"SB.218078, LY2603618, SCH.900776",0.0570004066339595,0.00348832784582135,FALSE +"H460","Pearson.est","cyclooxygenase inhibitor",0.32339,0.865,0.586,150,0.724,"naproxen, pterostilbene, metoxibutropate, FK.3311",0.232102383981909,0.140261433802853,FALSE +"H460","Pearson.est","cytochrome P450 inhibitor",0.81424,2.2,0,137,0.0217,"morin, itraconazole, metyrapone, eplerenone",Inf,1.66354026615147,TRUE +"H460","Pearson.est","DNA alkylating agent",-0.43781,-1.11,0.34,1100,0.77,"estramustine, carmustine, TH.302, mitomycin.c, carboplatin",0.468521082957745,0.113509274827518,FALSE +"H460","Pearson.est","DNA inhibitor",-0.45255,-1.14,0.312,1103,0.774,"nimorazole, carmustine, teroxirone, valrubicin, carboplatin, mechlorethamine",0.505845405981557,0.111259039317107,FALSE +"H460","Pearson.est","DNA methyltransferase inhibitor",-0.60083,-1.52,0.0789,1153,0.417,"fdcyd, azacitidine, disulfiram, decitabine",1.10292299679058,0.379863945026242,FALSE +"H460","Pearson.est","DNA polymerase inhibitor",0.31947,0.855,0.622,99,0.683,"famciclovir, cephalomannine",0.206209615309181,0.165579296318467,FALSE +"H460","Pearson.est","DNA synthesis inhibitor",-0.40652,-1.04,0.398,1312,0.686,"capecitabine, cyclocytidine, floxuridine, mitomycin.c, anisomycin",0.400116927926312,0.163675884293248,FALSE +"H460","Pearson.est","dopamine receptor antagonist",-0.20666,-0.522,0.972,988,0.97,"paliperidone, acetophenazine, oxiperomide, ziprasidone, mesoridazine, thioproperazine, UH.232....",0.0123337350737254,0.0132282657337552,FALSE +"H460","Pearson.est","estrogen receptor agonist",-0.26032,-0.657,0.86,1068,0.957,"equol, PPT",0.0655015487564323,0.0190880622231565,FALSE +"H460","Pearson.est","estrogen receptor antagonist",0.62329,1.66,0.0413,289,0.27,"toremifene, fulvestrant, raloxifene, tamoxifen",1.3840499483436,0.568636235841013,FALSE +"H460","Pearson.est","FGFR inhibitor",0.404,1.08,0.335,312,0.526,"erdafitinib, lucitanib, orantinib, lenvatinib",0.474955192963155,0.279014255846261,FALSE +"H460","Pearson.est","FLT3 inhibitor",-0.40024,-1.01,0.408,1220,0.721,"dovitinib, sunitinib, TG.02, TG.101348, pacritinib, ENMD.2076",0.38933983691012,0.142064735280571,FALSE +"H460","Pearson.est","glucocorticoid receptor agonist",0.22773,0.62,0.875,95,0.906,"triamcinolone.acetonide, piretanide",0.0579919469776868,0.0428718023231869,FALSE +"H460","Pearson.est","glutamate receptor antagonist",0.48841,1.28,0.212,357,0.345,"kynurenic.acid, JNJ.16259685, MTPG, LY456236, felbamate, CGP.37849, tiletamine",0.673664139071249,0.462180904926726,FALSE +"H460","Pearson.est","glycogen synthase kinase inhibitor",-0.24751,-0.622,0.898,1195,0.936,"LY2090314, indirubin",0.0467236633326956,0.0287241512618947,FALSE +"H460","Pearson.est","growth factor receptor inhibitor",-0.42985,-1.07,0.386,756,0.729,"AZD3463, GSK1904529A, danusertib, GSK1838705A, lestaurtinib, PHA.848125",0.413412695328245,0.137272471682025,FALSE +"H460","Pearson.est","HCV inhibitor",-0.48754,-1.23,0.247,1446,0.679,"narlaprevir",0.607303046740334,0.168130225719498,FALSE +"H460","Pearson.est","HDAC inhibitor",-0.5704,-1.44,0.0893,1040,0.503,"scriptaid, panobinostat, belinostat, R306465, entinostat, M.344, PCI.24781, romidepsin, RG2833, JNJ.26481585, resminostat, AR.42, dacinostat, trichostatin.a, chidamide, vorinostat, givinostat",1.04914854111145,0.298432014944073,FALSE +"H460","Pearson.est","histamine receptor antagonist",0.32882,0.864,0.616,324,0.696,"famotidine, chloropyramine, lafutidine, cimetidine, ICI.162846, ebastine",0.210419287835575,0.157390760389438,FALSE +"H460","Pearson.est","HMGCR inhibitor",0.71528,1.91,0.0185,323,0.105,"lovastatin, mevastatin, fluvastatin, pitavastatin, atorvastatin",1.73282827159699,0.978810700930062,TRUE +"H460","Pearson.est","HSP inhibitor",-0.60827,-1.53,0.07,1097,0.445,"XL888, SNX.2112, BIIB021, NVP.AUY922, VER.49009, ganetespib, tanespimycin, PU.H71",1.15490195998574,0.351639989019068,FALSE +"H460","Pearson.est","JAK inhibitor",-0.50011,-1.26,0.206,965,0.653,"atiprimod, lestaurtinib, AZD1480, TG.101209, WHI.P154, AZ960, TG.02, TG.101348, pacritinib, filgotinib",0.686132779630847,0.185086818724926,FALSE +"H460","Pearson.est","KIT inhibitor",-0.43446,-1.09,0.364,1257,0.777,"KI.8751, sunitinib, OSI.930, imatinib",0.438898616350944,0.109578981199086,FALSE +"H460","Pearson.est","MDM inhibitor",-0.72352,-1.84,0.015,1375,0.482,"CGM097, nutlin.3, idasanutlin",1.82390874094432,0.31695296176115,FALSE +"H460","Pearson.est","MEK inhibitor",-0.70314,-1.78,0.0209,1289,0.378,"refametinib, PD.184352, PD.318088, Ro.4987655, cobimetinib, selumetinib, MEK162, PD.0325901, AZD8330, TAK.733, trametinib, AS.703026",1.67985371388895,0.422508200162775,FALSE +"H460","Pearson.est","MET inhibitor",0.47952,1.3,0.173,563,0.397,"PHA.665752, NVP.BVU972, PF.04217903, INC.280",0.761953896871205,0.401209493236885,FALSE +"H460","Pearson.est","microtubule inhibitor",0.26716,0.731,0.799,13,0.838,"estramustine.phosphate",0.0974532206860086,0.0767559813697235,FALSE +"H460","Pearson.est","mTOR inhibitor",-0.43216,-1.08,0.366,1027,0.736,"AZD8055, voxtalisib, GDC.0980, temsirolimus, WAY.600, GSK2126458, PP242, LY303511, XL388, MLN0128, ku.0063794, AZD2014, everolimus, NVP.BEZ235",0.436518914605589,0.133122185662501,FALSE +"H460","Pearson.est","NFkB pathway inhibitor",-0.29216,-0.742,0.797,1341,0.948,"curcumin, betulinic.acid",0.0985416786038876,0.0231916626619338,FALSE +"H460","Pearson.est","opioid receptor agonist",-0.49745,-1.26,0.2,1419,0.653,"salvinorin.a",0.698970004336019,0.185086818724926,FALSE +"H460","Pearson.est","p38 MAPK inhibitor",0.54527,1.4,0.126,226,0.373,"TAK.715, SB.239063",0.899629454882437,0.428291168191312,FALSE +"H460","Pearson.est","PARP inhibitor",-0.43053,-1.11,0.333,1125,0.77,"niraparib, endo.IWR.1, talazoparib, olaparib",0.47755576649368,0.113509274827518,FALSE +"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.51796,-1.34,0.172,1084,0.636,"nintedanib, vatalanib, trapidil, CP.673451, linifanib, dovitinib, KI.8751, sunitinib, axitinib, crenolanib, imatinib",0.764471553092451,0.196542884351586,FALSE +"H460","Pearson.est","phosphatase inhibitor",0.58842,1.56,0.0869,553,0.344,"BVT.948, AS.1949490, alexidine, mycophenolate.mofetil, mycophenolic.acid, menadione, GSK2830371, sodium.stibogluconate, CID.5458317",1.06098022355133,0.46344155742847,FALSE +"H460","Pearson.est","phosphodiesterase inhibitor",0.36522,0.965,0.479,142,0.683,"enoximone, GSK256066",0.319664486585437,0.165579296318467,FALSE +"H460","Pearson.est","PI3K inhibitor",-0.39331,-0.988,0.47,1091,0.741,"CH5132799, GDC.0980, alpelisib, PIK.75, GSK2126458, TG.100713, LY303511, CUDC.907, NVP.BEZ235",0.327902142064283,0.130181792020672,FALSE +"H460","Pearson.est","PLK inhibitor",-0.6541,-1.63,0.0328,1217,0.419,"GW.843682X, volasertib, NMS.1286937, rigosertib",1.48412615628832,0.377785977033705,FALSE +"H460","Pearson.est","potassium channel blocker",0.39862,1.08,0.337,129,0.526,"dofetilide, ibutilide",0.472370099128661,0.279014255846261,FALSE +"H460","Pearson.est","PPAR receptor agonist",0.66959,1.78,0.0428,241,0.176,"pterostilbene, GW.501516, fenofibrate, S26948",1.36855623098683,0.75448733218585,TRUE +"H460","Pearson.est","progesterone receptor agonist",0.55353,1.47,0.0998,291,0.415,"norgestrel, nomegestrol.acetate, norethindrone.acetate, dienogest",1.00086945871263,0.381951903287907,FALSE +"H460","Pearson.est","proteasome inhibitor",0.51479,1.38,0.12,259,0.362,"oprozomib, ONX.0914, delanzomib",0.920818753952375,0.441291429466834,FALSE +"H460","Pearson.est","protein synthesis inhibitor",-0.26844,-0.676,0.838,1179,0.999,"emetine, homoharringtonine, anguidine, tedizolid.phosphate, thiostrepton",0.0767559813697235,0.000434511774017692,FALSE +"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.48258,-1.26,0.229,1022,0.653,"BMS.599626, NVP.TAE226, AV.412, CP.724714, mubritinib",0.640164517660112,0.185086818724926,FALSE +"H460","Pearson.est","RAF inhibitor",-0.36256,-0.905,0.558,932,0.849,"RAF265, SB.590885, vemurafenib, TAK.632, AZ.628, CEP.32496, dabrafenib",0.253365801062421,0.0710923097560473,FALSE +"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.2658,-0.659,0.875,1274,0.975,"sunitinib",0.0579919469776868,0.0109953843014632,FALSE +"H460","Pearson.est","retinoid receptor agonist",-0.31124,-0.799,0.684,1058,0.901,"tamibarotene, CD.437, bexarotene, adarotene",0.164943898279884,0.045275209020937,FALSE +"H460","Pearson.est","ribonucleotide reductase inhibitor",0.35143,0.942,0.505,942,0.689,"hydroxyurea, clofarabine, pentostatin, cladribine, cytarabine, fludarabine, triapine, gemcitabine, fludarabine.phosphate, LY2334737",0.296708621881339,0.161780778092374,FALSE +"H460","Pearson.est","serotonin receptor antagonist",-0.30645,-0.766,0.743,988,0.932,"paliperidone, RS.16566, pirenperone, ziprasidone, SB.200646, SB.216641",0.129011186239425,0.0305840876460186,FALSE +"H460","Pearson.est","sodium channel blocker",0.34661,0.939,0.506,344,0.662,"cibenzoline, oxcarbazepine, benzethonium, benzocaine, quinidine",0.295849483160201,0.1791420105603,FALSE +"H460","Pearson.est","src inhibitor",-0.24982,-0.628,0.91,1173,0.968,"TG.100572, KX2.391",0.0409586076789064,0.0141246426916063,FALSE +"H460","Pearson.est","sterol demethylase inhibitor",-0.36313,-0.926,0.541,914,0.833,"lanoconazole, ketoconazole",0.266802734893431,0.0793549985932124,FALSE +"H460","Pearson.est","TGF beta receptor inhibitor",0.25815,0.697,0.804,1075,0.852,"LY2109761, SB.525334, repsox, adaprev, D.4476, SB.431542",0.0947439512515487,0.0695604052332999,FALSE +"H460","Pearson.est","thymidylate synthase inhibitor",-0.59503,-1.51,0.066,1312,0.396,"capecitabine, trifluridine, carmofur",1.18045606445813,0.402304814074488,FALSE +"H460","Pearson.est","topoisomerase inhibitor",-0.31393,-0.807,0.688,960,0.909,"genz.644282, camptothecin, SN.38, licochalcone.a, TAS.103, rubitecan, amsacrine, mitoxantrone, voreloxin, idarubicin, amonafide, valrubicin",0.162411561764489,0.0414361167780325,FALSE +"H460","Pearson.est","tubulin polymerization inhibitor",-0.61095,-1.53,0.0691,989,0.445,"podophyllotoxin, albendazole, dolastatin.10, vindesine, plinabulin, epothilone.d, BNC105, vinblastine, ABT.751, docetaxel, taltobulin, flubendazole, parbendazole, combretastatin.A.4, verubulin, KX2.391, epothilone.b, fosbretabulin",1.1605219526258,0.351639989019068,FALSE +"H460","Pearson.est","tyrosine kinase inhibitor",-0.33414,-0.855,0.622,978,0.872,"AMG.208, BMS.599626, NVP.TAE226, tivantinib, AV.412, aminopurvalanol.a, UNC2250, sunitinib, tyrphostin.AG.99, CP.724714, mubritinib",0.206209615309181,0.0594835150674328,FALSE +"H460","Pearson.est","VEGFR inhibitor",-0.43721,-1.08,0.356,1084,0.736,"nintedanib, vatalanib, golvatinib, TG.100572, linifanib, dovitinib, tivozanib, foretinib, KI.8751, MGCD.265, sunitinib, semaxanib, OSI.930, axitinib, ENMD.2076",0.448550002027125,0.133122185662501,FALSE +"H460","Pearson.est","vitamin D receptor agonist",-0.46528,-1.16,0.298,1002,0.767,"calcitriol, alfacalcidol, doxercalciferol, tacalcitol, ercalcitriol",0.525783735923745,0.115204636051019,FALSE +"H1299","Pearson.est","EGFR inhibitor",0.50186,1.29,0.196,430,0.65,"OSI.420, tyrphostin.AG.1478, erlotinib, gefitinib, BIBX.1382, WZ8040, icotinib, CP.724714, BIBU.1361, AZD8931, dacomitinib, osimertinib, pelitinib, canertinib, PD.153035, AST.1306, poziotinib, tyrphostin.AG.494, afatinib, BMS.690514, lapatinib, CGP.52411, ARRY.334543, XL.647, neratinib, WZ.3146, PD.168393",0.707743928643524,0.187086643357144,FALSE +"H1299","Pearson.est","Abl kinase inhibitor",-0.54426,-1.41,0.114,973,0.368,"dasatinib, bafetinib, metatinib, nilotinib, flumatinib, GZD824, ponatinib",0.943095148663527,0.434152181326482,FALSE +"H1299","Pearson.est","acetylcholine receptor agonist",-0.33247,-0.887,0.575,1192,0.681,"xanomeline, tremorine",0.24033215531037,0.166852888087215,FALSE +"H1299","Pearson.est","acetylcholine receptor antagonist",0.28589,0.741,0.781,424,0.911,"darifenacin, diphemanil, dicycloverine",0.1073489661227,0.0404816230270017,FALSE +"H1299","Pearson.est","adenosine receptor antagonist",0.85637,2.2,0,59,0.00751,"SCH.58261, CGS.15943, MRS.1220, PSB.1115",Inf,2.12436006299583,TRUE +"H1299","Pearson.est","adrenergic receptor agonist",0.52866,1.37,0.137,408,0.707,"oxymetazoline, clenbuterol, lidamidine, metaraminol, methyldopa, isoxsuprine, A61603",0.863279432843593,0.150580586203101,FALSE +"H1299","Pearson.est","adrenergic receptor antagonist",0.34974,0.873,0.59,127,1,"levobunolol, imiloxan, dronedarone, atenolol....",0.229147988357856,0,FALSE +"H1299","Pearson.est","AKT inhibitor",0.49189,1.27,0.197,341,0.64,"CCT128930, uprosertib, GDC.0068, palomid.529, AZD5363",0.705533773838407,0.193820026016113,FALSE +"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.40064,1,0.449,102,0.859,"NVP.TAE684, GW.788388",0.347753658996677,0.0660068361687577,FALSE +"H1299","Pearson.est","androgen receptor antagonist",0.45692,1.16,0.283,363,0.795,"enzalutamide, cyproterone.acetate",0.54821356447571,0.0996328713435297,FALSE +"H1299","Pearson.est","antioxidant",0.39206,1.02,0.423,487,0.853,"benfotiamine, taurine, chlorogenic.acid, mesna",0.373659632624958,0.069050968832477,FALSE +"H1299","Pearson.est","AP inhibitor",-0.48103,-1.24,0.237,1432,0.466,"idronoxil",0.625251653989896,0.33161408331,FALSE +"H1299","Pearson.est","ATPase inhibitor",-0.53703,-1.37,0.149,1135,0.369,"digitoxigenin, ouabain, thonzonium, k.strophanthidin, digoxin, oligomycin.a",0.826813731587726,0.43297363384094,FALSE +"H1299","Pearson.est","Aurora kinase inhibitor",-0.35907,-0.903,0.54,1213,0.677,"CYC116, MK.5108, AMG900, aurora.a.inhibitor.i, CCT137690",0.267606240177031,0.169411331314856,FALSE +"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.43403,-1.1,0.328,1198,0.572,"josamycin, valnemulin",0.484126156288321,0.242603971206976,FALSE +"H1299","Pearson.est","bacterial DNA gyrase inhibitor",0.1921,0.491,0.982,340,1,"finafloxacin, trovafloxacin",0.00788851221305034,0,FALSE +"H1299","Pearson.est","BCL inhibitor",-0.37014,-0.957,0.5,1329,0.634,"gossypol, ABT.737",0.301029995663981,0.197910742118267,FALSE +"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.5751,-1.48,0.0996,973,0.362,"dasatinib, bafetinib, metatinib, nilotinib, flumatinib, GZD824, ponatinib",1.0017406615763,0.441291429466834,FALSE +"H1299","Pearson.est","benzodiazepine receptor agonist",0.49407,1.26,0.203,301,0.616,"gamma.aminobutyric.acid, lorazepam, nefiracetam, piperazine, eprinomectin, zaleplon",0.692503962086787,0.210419287835575,FALSE +"H1299","Pearson.est","bromodomain inhibitor",-0.32005,-0.821,0.661,1068,0.719,"bromosporine, PFI.1",0.17979854051436,0.143271109617117,FALSE +"H1299","Pearson.est","calcium channel blocker",-0.34313,-0.855,0.64,1438,0.71,"carboxyamidotriazole",0.193820026016113,0.148741651280925,FALSE +"H1299","Pearson.est","CC chemokine receptor antagonist",-0.46219,-1.2,0.218,1416,0.475,"UNBS.5162",0.661543506395395,0.323306390375133,FALSE +"H1299","Pearson.est","CDK inhibitor",0.40329,1.03,0.398,381,0.87,"indirubin, arcyriaflavin.a, alvocidib, JNJ.7706621, BMS.387032, kenpaullone, P276.00, AZD5438, TG.02",0.400116927926312,0.0604807473813815,FALSE +"H1299","Pearson.est","CHK inhibitor",-0.31159,-0.821,0.68,449,0.719,"SCH.900776, CHIR.124, LY2603618, SB.218078, LY2606368, AZD7762, PF.477736",0.167491087293764,0.143271109617117,FALSE +"H1299","Pearson.est","cyclooxygenase inhibitor",0.31872,0.803,0.691,184,0.938,"tryptanthrin, FK.3311, phenylbutazone, FR.122047, amfenac",0.160521952625802,0.0277971616209356,FALSE +"H1299","Pearson.est","cytochrome P450 inhibitor",0.45151,1.14,0.295,222,0.747,"PF.4981517, morin, itraconazole",0.530177984021837,0.126679398184601,FALSE +"H1299","Pearson.est","DNA alkylating agent",0.1915,0.488,0.994,179,0.985,"dacarbazine, ifosfamide",0.00261361560268669,0.00656376950238827,FALSE +"H1299","Pearson.est","DNA inhibitor",0.29509,0.749,0.78,18,0.924,"busulfan, nithiamide",0.10790539730952,0.0343280287798933,FALSE +"H1299","Pearson.est","DNA methyltransferase inhibitor",0.31622,0.82,0.672,37,0.935,"azacitidine",0.172630726946175,0.0291883891274822,FALSE +"H1299","Pearson.est","DNA polymerase inhibitor",0.43087,1.1,0.329,15,0.794,"famciclovir",0.482804102050026,0.100179497572904,FALSE +"H1299","Pearson.est","DNA synthesis inhibitor",0.26804,0.688,0.824,130,0.94,"altretamine, estramustine.phosphate",0.0840727883028842,0.0268721464003014,FALSE +"H1299","Pearson.est","dopamine receptor antagonist",0.34915,0.908,0.524,417,0.987,"acetophenazine, ziprasidone, domperidone, remoxipride, oxiperomide, nemonapride, mesoridazine, sertindole, UH.232...., clebopride",0.280668713016273,0.00568284733036327,FALSE +"H1299","Pearson.est","estrogen receptor agonist",-0.44971,-1.14,0.306,1137,0.538,"estrone, levonorgestrel",0.51427857351842,0.269217724333611,FALSE +"H1299","Pearson.est","estrogen receptor antagonist",-0.60297,-1.58,0.0571,1042,0.33,"tamoxifen, toremifene, raloxifene",1.24336389175415,0.481486060122112,FALSE +"H1299","Pearson.est","FGFR inhibitor",-0.59386,-1.57,0.0531,1298,0.305,"lenvatinib, nintedanib, dovitinib, erdafitinib, regorafenib",1.27490547891853,0.515700160653214,FALSE +"H1299","Pearson.est","FLT3 inhibitor",-0.54511,-1.42,0.12,1203,0.382,"midostaurin, quizartinib, tyrphostin.AG.1296, TG.101348, dovitinib, ponatinib, sorafenib",0.920818753952375,0.417936637088291,FALSE +"H1299","Pearson.est","glucocorticoid receptor agonist",-0.17553,-0.446,0.996,975,0.994,"beclomethasone.dipropionate, triamcinolone, fluorometholone, rimexolone, halobetasol.propionate, fluticasone.propionate, flumethasone.pivalate, prednisolone.acetate, deflazacort",0.00174066157630127,0.00261361560268669,FALSE +"H1299","Pearson.est","glutamate receptor antagonist",0.43567,1.15,0.301,451,0.769,"diazooxonorleucine, latrepirdine, kynurenic.acid, JNJ.16259685, CPP, SIB.1757, felbamate",0.521433504406157,0.114073660198569,FALSE +"H1299","Pearson.est","glycogen synthase kinase inhibitor",0.34114,0.871,0.589,106,0.993,"indirubin, CHIR.99021",0.229884705212898,0.00305075150461883,FALSE +"H1299","Pearson.est","growth factor receptor inhibitor",0.3327,0.841,0.632,134,0.987,"GSK1904529A",0.199282921717615,0.00568284733036327,FALSE +"H1299","Pearson.est","HCV inhibitor",-0.38825,-1.02,0.414,1447,0.58,"narlaprevir",0.382999658879101,0.236572006437063,FALSE +"H1299","Pearson.est","HDAC inhibitor",0.53523,1.37,0.152,211,0.707,"tacedinaline, JNJ.26481585, nexturastat.a, romidepsin, panobinostat, pyroxamide, vorinostat, R306465",0.818156412055227,0.150580586203101,FALSE +"H1299","Pearson.est","histamine receptor antagonist",0.28086,0.736,0.779,472,0.895,"terfenadine, famotidine, chloropyramine, ranitidine, levocetirizine, astemizole, zolantidine, tecastemizole, pheniramine, lafutidine",0.108462542327436,0.048176964684088,FALSE +"H1299","Pearson.est","HMGCR inhibitor",-0.69071,-1.72,0.0312,996,0.276,"lovastatin, simvastatin, mevastatin, fluvastatin, atorvastatin, pitavastatin",1.50584540598156,0.559090917934782,FALSE +"H1299","Pearson.est","HSP inhibitor",-0.27691,-0.702,0.814,923,0.862,"BIIB021, NMS.E973, PU.H71, alvespimycin, NVP.AUY922, ganetespib, SNX.2112",0.0893755951107988,0.0644927341752872,FALSE +"H1299","Pearson.est","JAK inhibitor",0.21217,0.54,0.96,125,1,"CEP.33779, atiprimod",0.0177287669604316,0,FALSE +"H1299","Pearson.est","KIT inhibitor",-0.57724,-1.49,0.0936,1203,0.386,"midostaurin, masitinib, lenvatinib, pazopanib, sorafenib, regorafenib",1.02872415126189,0.413412695328245,FALSE +"H1299","Pearson.est","MDM inhibitor",0.64637,1.7,0.0236,506,0.465,"nutlin.3, CGM097, RITA, idasanutlin, serdemetan",1.62708799702989,0.332547047110046,FALSE +"H1299","Pearson.est","MEK inhibitor",0.71696,1.85,0.00595,336,0.25,"BIX.02188, AS.703026, selumetinib, PD.0325901, cobimetinib, trametinib, PD.198306, MEK162, refametinib, Ro.4987655, PD.184352, TAK.733, AZD8330",2.22548303427145,0.602059991327962,FALSE +"H1299","Pearson.est","MET inhibitor",-0.37292,-0.966,0.475,1406,0.641,"LY2801653",0.323306390375133,0.193141970481183,FALSE +"H1299","Pearson.est","microtubule inhibitor",-0.5271,-1.35,0.169,1141,0.37,"podophyllotoxin, vinblastine, secnidazole, D.64131, cabazitaxel",0.772113295386326,0.431798275933005,FALSE +"H1299","Pearson.est","mTOR inhibitor",0.20325,0.52,0.972,391,1,"PP242, PI.103, palomid.529, XL388, torin.2, WAY.600, LY303511, AZD8055, GSK2126458, PF.05212384",0.0123337350737254,0,FALSE +"H1299","Pearson.est","NFkB pathway inhibitor",0.31021,0.793,0.655,460,0.876,"bindarit, IKK.2.inhibitor.V, betulinic.acid, parthenolide...., tyloxapol",0.183758700008217,0.0574958938319193,FALSE +"H1299","Pearson.est","opioid receptor agonist",0.30766,0.799,0.688,360,0.917,"salvinorin.a, BW.180C",0.162411561764489,0.0376306643299789,FALSE +"H1299","Pearson.est","p38 MAPK inhibitor",0.52106,1.33,0.158,421,0.667,"SB.239063, skepinone.l, TAK.715, SB.242235, CMPD.1",0.801342913045577,0.175874166083451,FALSE +"H1299","Pearson.est","PARP inhibitor",0.30896,0.796,0.697,283,0.896,"PJ.34, endo.IWR.1",0.156767221901991,0.0476919903378748,FALSE +"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.57721,-1.47,0.0961,1196,0.341,"linifanib, axitinib, masitinib, lenvatinib, crenolanib, nintedanib, dovitinib, pazopanib, ponatinib, sorafenib, regorafenib",1.01727661233145,0.467245621007502,FALSE +"H1299","Pearson.est","phosphatase inhibitor",-0.4204,-1.06,0.359,1232,0.564,"GSK2830371, CID.5458317, bis.maltolato.oxovanadium.IV.",0.444905551421681,0.248720896016658,FALSE +"H1299","Pearson.est","phosphodiesterase inhibitor",0.58881,1.54,0.0668,288,0.639,"cilostamide, zardaverine, GSK256066, anagrelide",1.17522353752445,0.1944991418416,FALSE +"H1299","Pearson.est","PI3K inhibitor",0.25132,0.653,0.876,391,0.958,"pilaralisib, alpelisib, CH5132799, PI.103, idelalisib, PI.828, AZD6482, LY303511, TG.100713, GSK2126458, TG100.115, PF.05212384",0.0574958938319193,0.0186344909214556,FALSE +"H1299","Pearson.est","PLK inhibitor",-0.80985,-2.07,0.0021,1167,0.0537,"rigosertib, HMN.214, GW.843682X, NMS.1286937, volasertib, GSK461364, BI.2536",2.67778070526608,1.27002571430044,TRUE +"H1299","Pearson.est","potassium channel blocker",0.52573,1.36,0.163,145,0.662,"oleoylethanolamide, ibutilide",0.787812395596042,0.1791420105603,FALSE +"H1299","Pearson.est","PPAR receptor agonist",0.50097,1.29,0.212,335,0.65,"oleoylethanolamide, S26948, clofibrate, pterostilbene",0.673664139071249,0.187086643357144,FALSE +"H1299","Pearson.est","progesterone receptor agonist",0.31764,0.835,0.644,109,0.967,"norethindrone.acetate, dienogest",0.191114132640188,0.0145735259169983,FALSE +"H1299","Pearson.est","proteasome inhibitor",-0.3975,-1.03,0.401,1345,0.586,"delanzomib",0.396855627379818,0.232102383981909,FALSE +"H1299","Pearson.est","protein synthesis inhibitor",-0.35713,-0.929,0.531,1222,0.657,"bruceantin, puromycin, harringtonine, mercaptopurine, anguidine",0.274905478918531,0.182434630440219,FALSE +"H1299","Pearson.est","protein tyrosine kinase inhibitor",-0.42631,-1.09,0.369,1140,0.563,"AV.412, tyrphostin.A9, rheochrysidin, mubritinib",0.43297363384094,0.249491605148654,FALSE +"H1299","Pearson.est","RAF inhibitor",-0.48538,-1.28,0.192,1297,0.436,"RAF265, TAK.632, sorafenib, regorafenib",0.71669877129645,0.360513510731414,FALSE +"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.63386,-1.6,0.0673,1421,0.35,"sorafenib, regorafenib",1.17198493577602,0.455931955649724,FALSE +"H1299","Pearson.est","retinoid receptor agonist",0.32755,0.843,0.633,325,1,"adarotene, CD.437, AM.580, tamibarotene",0.198596289982645,0,FALSE +"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.76235,-2,0.00204,1301,0.0579,"LY2334737, triapine, clofarabine, gemcitabine, pentostatin, cladribine",2.6903698325741,1.23732143627256,TRUE +"H1299","Pearson.est","serotonin receptor agonist",0.63387,1.62,0.0419,129,0.547,"aripiprazole, ipsapirone",1.3777859770337,0.262012673666569,FALSE +"H1299","Pearson.est","serotonin receptor antagonist",0.40655,1.04,0.375,347,0.89,"aripiprazole, ziprasidone, SB.228357, tropisetron, sertindole",0.425968732272281,0.0506099933550872,FALSE +"H1299","Pearson.est","sodium channel blocker",0.32089,0.832,0.658,339,0.941,"lappaconite, benzethonium, A.803467, triamterene, ajmaline",0.181774106386044,0.0264103765727431,FALSE +"H1299","Pearson.est","src inhibitor",0.37818,0.976,0.471,193,0.874,"PP.2, PP.1, saracatinib",0.326979092871104,0.058488567365597,FALSE +"H1299","Pearson.est","sterol demethylase inhibitor",-0.55473,-1.4,0.136,1005,0.354,"posaconazole, ketoconazole, sulconazole, chlormidazole, lanoconazole",0.866461091629782,0.450996737974212,FALSE +"H1299","Pearson.est","TGF beta receptor inhibitor",0.5658,1.45,0.104,228,0.779,"LY2109761, D.4476",0.98296666070122,0.108462542327436,FALSE +"H1299","Pearson.est","thymidylate synthase inhibitor",-0.21988,-0.571,0.935,1253,0.969,"trifluridine",0.0291883891274822,0.0136762229492347,FALSE +"H1299","Pearson.est","topoisomerase inhibitor",-0.71905,-1.81,0.00984,1176,0.194,"dexrazoxane, rubitecan, etoposide, topotecan, epirubicin, nemorubicin, amsacrine, exatecan.mesylate, SN.38, teniposide, voreloxin, doxorubicin, amonafide, daunorubicin, valrubicin, etoposide.phosphate, idarubicin, TAS.103, mitoxantrone",2.00700490156866,0.712198270069774,TRUE +"H1299","Pearson.est","tubulin polymerization inhibitor",-0.6475,-1.67,0.0456,1009,0.292,"paclitaxel, nocodazole, plinabulin, oxibendazole, podophyllotoxin, ABT.751, CYT.997, KX2.391, parbendazole, vincristine, fenbendazole, BNC105, vinblastine, vindesine, verubulin, taltobulin, epothilone.b, dolastatin.10, flubendazole, mebendazole, docetaxel",1.34103515733556,0.534617148551582,FALSE +"H1299","Pearson.est","tyrosine kinase inhibitor",-0.41944,-1.06,0.37,973,0.564,"dasatinib, bafetinib, sunitinib, aminopurvalanol.a, tyrphostin.AG.99, AV.412, cabozantinib, tyrphostin.A9, rheochrysidin, hypericin, mubritinib, sorafenib, regorafenib",0.431798275933005,0.248720896016658,FALSE +"H1299","Pearson.est","VEGFR inhibitor",-0.4705,-1.22,0.233,1196,0.47,"linifanib, axitinib, TG.100572, RAF265, lenvatinib, nintedanib, dovitinib, golvatinib, pazopanib, tivozanib, foretinib, sorafenib, regorafenib",0.632644078973981,0.327902142064283,FALSE +"H1299","Pearson.est","vitamin D receptor agonist",0.53526,1.41,0.11,225,0.788,"maxacalcitol, calcitriol, ercalcitriol, paricalcitol",0.958607314841775,0.103473782510445,FALSE +"HCC44","Pearson.est","EGFR inhibitor",-0.12768,-0.329,1,853,1,"dacomitinib, AST.1306, canertinib, tucatinib, erlotinib, osimertinib, BIBX.1382, CP.724714, gefitinib, OSI.420, CUDC.101, FERb.033, BMS.690514, BMS.599626, WZ8040, CGP.52411, BIBU.1361, tyrphostin.AG.1478, tyrphostin.AG.494",0,0,FALSE +"HCC44","Pearson.est","Abl kinase inhibitor",0.32323,0.85,0.621,394,0.975,"bafetinib, GZD824, flumatinib, ZM.306416, ponatinib, metatinib",0.20690839982342,0.0109953843014632,FALSE +"HCC44","Pearson.est","acetylcholine receptor agonist",-0.4241,-1.08,0.362,846,0.727,"tremorine, nefiracetam, oxiracetam, nicotine",0.441291429466834,0.138465589140962,FALSE +"HCC44","Pearson.est","acetylcholine receptor antagonist",0.68428,1.73,0.0193,426,0.553,"iododexetimide, hyoscyamine, diphemanil, darifenacin, methscopolamine",1.71444269099223,0.257274868695302,FALSE +"HCC44","Pearson.est","adenosine receptor antagonist",-0.31109,-0.783,0.705,1370,0.977,"PSB.1115",0.151810883008601,0.0101054362812269,FALSE +"HCC44","Pearson.est","adrenergic receptor agonist",0.29192,0.754,0.764,81,0.931,"xylazine, A61603",0.11690664142431,0.0310503190186574,FALSE +"HCC44","Pearson.est","adrenergic receptor antagonist",-0.27937,-0.693,0.809,1339,0.998,"atipamezole, dronedarone, levobunolol, imiloxan",0.0920514783877277,0.000869458712628891,FALSE +"HCC44","Pearson.est","AKT inhibitor",-0.49942,-1.28,0.227,1025,0.619,"GDC.0068, AZD5363, CCT128930, ONC201, uprosertib",0.643974142806877,0.208309350979882,FALSE +"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.44421,1.16,0.278,252,0.986,"AP26113, lorlatinib, NVP.TAE684, CEP.37440",0.555955204081924,0.0061230850587888,FALSE +"HCC44","Pearson.est","androgen receptor antagonist",-0.3531,-0.911,0.572,1428,0.932,"RU.58841",0.242603971206976,0.0305840876460186,FALSE +"HCC44","Pearson.est","antioxidant",-0.65149,-1.63,0.0536,1253,0.371,"chlorogenic.acid, benfotiamine, mesna",1.27083521030723,0.430626090384954,FALSE +"HCC44","Pearson.est","AP inhibitor",-0.25485,-0.643,0.899,1097,0.977,"GDC.0152, birinapant",0.0462403082667712,0.0101054362812269,FALSE +"HCC44","Pearson.est","ATPase inhibitor",-0.22186,-0.553,0.95,1158,1,"ouabain, digoxin, thonzonium",0.0222763947111523,0,FALSE +"HCC44","Pearson.est","Aurora kinase inhibitor",-0.49035,-1.23,0.232,1211,0.63,"barasertib, PF.03814735, CCT129202, ENMD.2076, alisertib, KW.2449, MK.8745, GSK1070916, MLN.8054",0.6345120151091,0.200659450546418,FALSE +"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.32309,0.817,0.676,67,0.97,"dirithromycin, josamycin",0.170053304058364,0.0132282657337552,FALSE +"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.50939,-1.3,0.168,1389,0.684,"novobiocin, finafloxacin",0.774690718274137,0.164943898279884,FALSE +"HCC44","Pearson.est","BCL inhibitor",-0.36632,-0.934,0.524,1122,0.921,"TW.37, HA14.1, venetoclax, oridonin",0.280668713016273,0.0357403698031511,FALSE +"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",0.37437,0.958,0.494,469,0.885,"bafetinib, GZD824, flumatinib, ponatinib, metatinib, bosutinib",0.306273051076353,0.0530567293021746,FALSE +"HCC44","Pearson.est","benzodiazepine receptor agonist",0.29612,0.765,0.748,332,0.941,"indiplon, bentazepam, gamma.aminobutyric.acid, piperazine, CL.218872",0.126098402135539,0.0264103765727431,FALSE +"HCC44","Pearson.est","bromodomain inhibitor",0.41894,1.07,0.35,60,0.895,"PFI.1",0.455931955649724,0.048176964684088,FALSE +"HCC44","Pearson.est","calcium channel blocker",-0.34739,-0.889,0.555,1297,0.906,"mibefradil, SR.33805, cinnarazine",0.255707016877324,0.0428718023231869,FALSE +"HCC44","Pearson.est","CC chemokine receptor antagonist",0.39852,1.03,0.412,125,0.942,"UNBS.5162, MK.0812",0.385102783966865,0.0259490972071227,FALSE +"HCC44","Pearson.est","CDK inhibitor",-0.57078,-1.45,0.12,1036,0.714,"P276.00, abemaciclib, JNJ.7706621, indisulam, BMS.265246, R547, kenpaullone, indirubin, alvocidib, TG.02, palbociclib, PHA.793887, ribociclib, AZD5438",0.920818753952375,0.146301788223826,FALSE +"HCC44","Pearson.est","CHK inhibitor",0.32205,0.819,0.667,439,1,"PF.477736, LY2606368, SB.218078",0.175874166083451,0,FALSE +"HCC44","Pearson.est","cyclooxygenase inhibitor",0.25544,0.661,0.859,354,0.979,"naproxen, AM.404, FK.3311, tepoxalin, metoxibutropate, acetylsalicylsalicylic.acid, pterostilbene, ramifenazone, phenazone",0.0660068361687577,0.00921730819686218,FALSE +"HCC44","Pearson.est","cytochrome P450 inhibitor",0.46516,1.17,0.276,409,1,"metyrapone, eplerenone, morin, cobicistat, clotrimazole",0.559090917934782,0,FALSE +"HCC44","Pearson.est","DNA alkylating agent",0.20514,0.515,0.954,455,0.998,"dianhydrogalactitol, mitomycin.c, cyclophosphamide, streptozotocin, dacarbazine, satraplatin",0.0204516252959049,0.000869458712628891,FALSE +"HCC44","Pearson.est","DNA inhibitor",-0.31349,-0.796,0.673,953,1,"metronidazole, sangivamycin, valrubicin, carboplatin, nithiamide, nimorazole, carmustine, busulfan",0.171984935776023,0,FALSE +"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.5399,-1.38,0.132,1380,0.807,"decitabine, azacitidine",0.87942606879415,0.0931264652779296,FALSE +"HCC44","Pearson.est","DNA polymerase inhibitor",-0.50278,-1.25,0.234,1041,0.635,"adefovir.dipivoxil, cidofovir, idoxuridine, foscarnet, trifluridine",0.630784142589857,0.197226274708024,FALSE +"HCC44","Pearson.est","DNA synthesis inhibitor",0.28054,0.703,0.821,329,0.979,"estramustine.phosphate, nelarabine, artesunate, mitomycin.c",0.0856568428805592,0.00921730819686218,FALSE +"HCC44","Pearson.est","dopamine receptor antagonist",-0.52503,-1.31,0.187,1141,0.728,"UH.232...., remoxipride, oxiperomide, domperidone, clebopride, acetophenazine, ziprasidone, mesoridazine",0.728158393463501,0.137868620686963,FALSE +"HCC44","Pearson.est","estrogen receptor agonist",0.45284,1.14,0.315,155,0.963,"levonorgestrel, estradiol.cypionate",0.501689446210399,0.0163737128754655,FALSE +"HCC44","Pearson.est","estrogen receptor antagonist",0.70856,1.8,0.0062,140,0.701,"toremifene, raloxifene, fulvestrant",2.20760831050175,0.154281982033341,FALSE +"HCC44","Pearson.est","FGFR inhibitor",0.64474,1.66,0.0385,346,0.331,"erdafitinib, lenvatinib, AZD4547, regorafenib, orantinib, dovitinib",1.4145392704915,0.480172006224281,FALSE +"HCC44","Pearson.est","FLT3 inhibitor",-0.30402,-0.778,0.735,1231,0.954,"tandutinib, TG.02, ENMD.2076, KW.2449, pacritinib",0.133712660915805,0.0204516252959049,FALSE +"HCC44","Pearson.est","glucocorticoid receptor agonist",0.22616,0.585,0.925,356,0.98,"fluorometholone, deflazacort, triamcinolone.acetonide, clobetasol.propionate, betamethasone, flumethasone.pivalate, fluticasone.propionate, prednisolone",0.0338582672609674,0.00877392430750515,FALSE +"HCC44","Pearson.est","glutamate receptor antagonist",0.37305,0.974,0.473,287,0.931,"LY456236, kynurenic.acid, tiletamine, MTPG, CGP.37849",0.325138859262188,0.0310503190186574,FALSE +"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.46347,-1.17,0.285,1205,0.596,"tideglusib, kenpaullone, indirubin, LY2090314",0.54515513999149,0.224753740259764,FALSE +"HCC44","Pearson.est","growth factor receptor inhibitor",-0.29563,-0.726,0.779,426,1,"GW.441756, PHA.848125, danusertib, AZD3463, lestaurtinib, GSK1838705A, GSK1904529A",0.108462542327436,0,FALSE +"HCC44","Pearson.est","HCV inhibitor",-0.48737,-1.22,0.234,1217,0.609,"daclatasvir, narlaprevir",0.630784142589857,0.215382707367125,FALSE +"HCC44","Pearson.est","HDAC inhibitor",-0.48037,-1.2,0.242,1113,0.609,"belinostat, AR.42, RGFP966, panobinostat, tacedinaline, PCI.24781, givinostat, vorinostat, pyroxamide, JNJ.26481585, romidepsin, R306465",0.616184634019569,0.215382707367125,FALSE +"HCC44","Pearson.est","histamine receptor antagonist",0.32467,0.816,0.674,538,0.94,"chloropyramine, tiotidine, ebastine, ICI.162846, BF2.649, zolantidine, lafutidine, astemizole, tecastemizole, cimetidine, nizatidine, famotidine, cyproheptadine",0.17134010346468,0.0268721464003014,FALSE +"HCC44","Pearson.est","HMGCR inhibitor",0.6515,1.64,0.0518,279,0.304,"pitavastatin, mevastatin, lovastatin",1.28567024025477,0.517126416391246,FALSE +"HCC44","Pearson.est","HSP inhibitor",-0.52358,-1.35,0.149,959,0.701,"KW.2478, ganetespib, VER.49009, PU.H71, tanespimycin, SNX.2112, SNX.5422, XL888, NVP.AUY922, BIIB021",0.826813731587726,0.154281982033341,FALSE +"HCC44","Pearson.est","JAK inhibitor",-0.24431,-0.627,0.893,1032,0.967,"AZ960, tozasertib, WHI.P154, TG.02, pacritinib, filgotinib",0.0491485411114536,0.0145735259169983,FALSE +"HCC44","Pearson.est","KIT inhibitor",-0.34353,-0.847,0.667,1231,0.957,"tandutinib, imatinib, KI.8751, OSI.930",0.175874166083451,0.0190880622231565,FALSE +"HCC44","Pearson.est","MDM inhibitor",-0.75386,-1.93,0,1374,0.0717,"CGM097, nutlin.3, idasanutlin",Inf,1.1444808443322,TRUE +"HCC44","Pearson.est","MEK inhibitor",-0.78085,-2.01,0.00762,1301,0.0507,"PD.198306, selumetinib, PD.184352, PD.318088, MEK162, refametinib, Ro.4987655, AS.703026, trametinib, cobimetinib, TAK.733, AZD8330, PD.0325901",2.1180450286604,1.29499204066666,TRUE +"HCC44","Pearson.est","MET inhibitor",0.33722,0.868,0.607,374,1,"PHA.665752, LY2801653, NVP.BVU972",0.216811308924742,0,FALSE +"HCC44","Pearson.est","microtubule inhibitor",0.41659,1.09,0.336,239,0.9,"estramustine.phosphate, colchicine, D.64131, cabazitaxel",0.473660722610156,0.0457574905606751,FALSE +"HCC44","Pearson.est","mTOR inhibitor",-0.2677,-0.68,0.847,899,0.987,"NVP.BEZ235, palomid.529, everolimus, sirolimus, AZD8055, temsirolimus, ku.0063794, AZD2014, torin.2, OSI.027, voxtalisib, WAY.600, LY303511, GSK2126458, PP242, XL388",0.0721165896692931,0.00568284733036327,FALSE +"HCC44","Pearson.est","NFkB pathway inhibitor",0.37746,0.966,0.46,207,0.906,"BAY.11.7082, tyloxapol, bindarit, EVP4593",0.337242168318426,0.0428718023231869,FALSE +"HCC44","Pearson.est","opioid receptor agonist",-0.63294,-1.64,0.0514,1378,0.44,"salvinorin.a, cebranopadol",1.28903688100472,0.356547323513813,FALSE +"HCC44","Pearson.est","p38 MAPK inhibitor",0.3299,0.859,0.631,298,0.994,"SB.242235, VX.702, SB.239063",0.199970640755866,0.00261361560268669,FALSE +"HCC44","Pearson.est","PARP inhibitor",-0.41041,-1.02,0.392,1094,0.812,"niraparib, olaparib, talazoparib",0.406713932979543,0.0904439707588247,FALSE +"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.25648,-0.65,0.875,1226,0.996,"CP.673451, tandutinib, imatinib, SU014813, KI.8751",0.0579919469776868,0.00174066157630127,FALSE +"HCC44","Pearson.est","phosphatase inhibitor",0.42915,1.09,0.325,401,0.9,"BVT.948, GSK2830371, AS.1949490, CID.5458317",0.488116639021126,0.0457574905606751,FALSE +"HCC44","Pearson.est","phosphodiesterase inhibitor",0.29938,0.765,0.742,312,0.941,"GSK256066, enoximone, trequinsin",0.129596094720973,0.0264103765727431,FALSE +"HCC44","Pearson.est","PI3K inhibitor",-0.289,-0.712,0.81,1239,1,"alpelisib, LY303511, GSK2126458, TG.100713, CUDC.907, CH5132799",0.0915149811213502,0,FALSE +"HCC44","Pearson.est","PLK inhibitor",0.59709,1.54,0.0646,75,0.431,"GSK461364, BI.2536",1.18976748200492,0.365522729839268,FALSE +"HCC44","Pearson.est","potassium channel blocker",-0.54319,-1.37,0.138,1195,0.73,"meglitinide, oleoylethanolamide, ML133",0.860120913598763,0.136677139879544,FALSE +"HCC44","Pearson.est","PPAR receptor agonist",0.31058,0.778,0.742,320,0.979,"GW.501516, pterostilbene, clofibrate",0.129596094720973,0.00921730819686218,FALSE +"HCC44","Pearson.est","progesterone receptor agonist",0.53725,1.37,0.145,248,0.745,"nomegestrol.acetate, levonorgestrel, norgestrel, norethindrone.acetate",0.838631997765025,0.127843727251707,FALSE +"HCC44","Pearson.est","proteasome inhibitor",-0.37258,-0.941,0.485,1051,0.947,"ixazomib, bortezomib, ixazomib.citrate, MG.132",0.314258261397736,0.0236500209967266,FALSE +"HCC44","Pearson.est","protein synthesis inhibitor",0.39507,1.01,0.411,148,0.94,"clofoctol, mercaptopurine, anguidine, puromycin, clindamycin.phosphate, homoharringtonine",0.386158178123931,0.0268721464003014,FALSE +"HCC44","Pearson.est","protein tyrosine kinase inhibitor",0.43151,1.1,0.35,206,1,"rheochrysidin, PP.121, tyrphostin.A9",0.455931955649724,0,FALSE +"HCC44","Pearson.est","RAF inhibitor",-0.30781,-0.786,0.715,1160,1,"SB.590885, AZ.628, dabrafenib",0.145693958198919,0,FALSE +"HCC44","Pearson.est","RET tyrosine kinase inhibitor",0.26699,0.675,0.842,1063,0.989,"regorafenib, vandetanib, cabozantinib, sorafenib, apatinib, sunitinib",0.0746879085003505,0.0048037084028206,FALSE +"HCC44","Pearson.est","retinoid receptor agonist",0.39427,1,0.424,301,0.916,"fenretinide, AM.580, LE.135, bexarotene",0.372634143407267,0.0381045263321496,FALSE +"HCC44","Pearson.est","ribonucleotide reductase inhibitor",0.64914,1.66,0.0429,337,0.331,"pentostatin, clofarabine, LY2334737, cladribine, fludarabine, gemcitabine, hydroxyurea",1.36754270781528,0.480172006224281,FALSE +"HCC44","Pearson.est","serotonin receptor agonist",-0.81222,-2.09,0,1228,0.0473,"SR.57227A, ipsapirone, aripiprazole",Inf,1.32513885926219,TRUE +"HCC44","Pearson.est","serotonin receptor antagonist",-0.50938,-1.29,0.2,1406,0.649,"ziprasidone, aripiprazole",0.698970004336019,0.187755303199631,FALSE +"HCC44","Pearson.est","sodium channel blocker",0.46183,1.19,0.266,36,1,"cibenzoline, oxcarbazepine",0.575118363368933,0,FALSE +"HCC44","Pearson.est","src inhibitor",0.49423,1.28,0.183,469,0.907,"PP.1, ZM.306416, TG.100572, KX2.391, saracatinib, bosutinib",0.737548910269571,0.0423927129399047,FALSE +"HCC44","Pearson.est","sterol demethylase inhibitor",0.65572,1.68,0.0362,447,0.49,"lanoconazole, ketoconazole, posaconazole, terconazole, chlormidazole",1.44129142946683,0.309803919971486,FALSE +"HCC44","Pearson.est","TGF beta receptor inhibitor",-0.34698,-0.904,0.587,920,0.91,"LY2109761, SB.431542, repsox, D.4476",0.231361898752386,0.0409586076789064,FALSE +"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.47431,-1.19,0.276,1196,0.593,"capecitabine, raltitrexed, carmofur, trifluridine",0.559090917934782,0.226945306635737,FALSE +"HCC44","Pearson.est","topoisomerase inhibitor",0.24928,0.641,0.88,167,0.977,"dexrazoxane, licochalcone.a, mitoxantrone, etoposide",0.0555173278498314,0.0101054362812269,FALSE +"HCC44","Pearson.est","tubulin polymerization inhibitor",0.18476,0.462,0.996,486,0.99,"CYT.997, dolastatin.10, ABT.751, vincristine, oxibendazole, mebendazole, nocodazole, KX2.391, paclitaxel, fenbendazole, indibulin, epothilone.d",0.00174066157630127,0.00436480540245009,FALSE +"HCC44","Pearson.est","tyrosine kinase inhibitor",0.23085,0.585,0.951,206,0.98,"rheochrysidin, bafetinib, PP.121, tyrphostin.A9",0.0218194830625861,0.00877392430750515,FALSE +"HCC44","Pearson.est","VEGFR inhibitor",-0.17543,-0.444,0.996,1255,1,"ENMD.2076, SU014813, KI.8751, MGCD.265, OSI.930",0.00174066157630127,0,FALSE +"HCC44","Pearson.est","vitamin D receptor agonist",0.34167,0.865,0.577,327,1,"doxercalciferol, maxacalcitol, paricalcitol",0.238824186844269,0,FALSE +"A549","Pearson.est","EGFR inhibitor",-0.21155,-0.549,0.946,1147,0.957,"CNX.2006, salvianolic.acid.B, CP.724714, PD.168393, lapatinib, CGP.52411, BIBU.1361, WZ8040, WZ.4002",0.0241088635982073,0.0190880622231565,FALSE +"A549","Pearson.est","Abl kinase inhibitor",0.2773,0.73,0.805,209,1,"bafetinib, flumatinib, GZD824",0.0942041196321315,0,FALSE +"A549","Pearson.est","acetylcholine receptor agonist",-0.26144,-0.692,0.826,377,0.932,"nefiracetam, pilocarpine, xanomeline, nicotine, tremorine, oxiracetam",0.0830199526796178,0.0305840876460186,FALSE +"A549","Pearson.est","acetylcholine receptor antagonist",0.71882,1.88,0.00781,298,0.428,"iododexetimide, diphemanil, hyoscyamine, methscopolamine, darifenacin",2.1073489661227,0.368556230986828,FALSE +"A549","Pearson.est","adenosine receptor antagonist",0.23437,0.62,0.899,477,1,"CGS.15943, MRS.1220, SCH.58261",0.0462403082667712,0,FALSE +"A549","Pearson.est","adrenergic receptor agonist",0.45738,1.18,0.274,168,1,"methyldopa, xylazine, A61603, ritodrine",0.562249437179612,0,FALSE +"A549","Pearson.est","adrenergic receptor antagonist",0.39377,1.01,0.41,231,0.958,"idazoxan, metoprolol, atenolol...., prazosin, RS.17053, practolol",0.387216143280265,0.0186344909214556,FALSE +"A549","Pearson.est","AKT inhibitor",-0.43911,-1.15,0.291,1341,0.61,"AZD5363, AT7867",0.536107011014093,0.214670164989233,FALSE +"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.3773,0.991,0.444,271,0.919,"lorlatinib, CEP.37440, NVP.TAE684, AP26113",0.35261702988538,0.0366844886138887,FALSE +"A549","Pearson.est","androgen receptor antagonist",0.42302,1.11,0.315,323,1,"enzalutamide, cyproterone.acetate, flutamide",0.501689446210399,0,FALSE +"A549","Pearson.est","antioxidant",-0.67242,-1.75,0.0316,1225,0.288,"trolox, rutin, mesna, chlorogenic.acid",1.5003129173816,0.540607512240769,FALSE +"A549","Pearson.est","AP inhibitor",0.25589,0.69,0.822,1079,1,"tanshinone.i, embelin, LCL.161, GDC.0152, idronoxil, birinapant",0.0851281824599496,0,FALSE +"A549","Pearson.est","ATPase inhibitor",0.43003,1.12,0.316,113,1,"k.strophanthidin, evodiamine",0.500312917381596,0,FALSE +"A549","Pearson.est","Aurora kinase inhibitor",-0.4402,-1.14,0.326,1031,0.593,"CCT137690, MK.5108, CCT129202, PHA.680632, CYC116, hesperadin, AMG900, MLN.8054, GSK1070916, KW.2449, PF.03814735",0.486782399932061,0.226945306635737,FALSE +"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.42231,-1.12,0.314,1323,0.595,"azalomycin.b, valnemulin, tedizolid, radezolid",0.503070351926785,0.22548303427145,FALSE +"A549","Pearson.est","bacterial DNA gyrase inhibitor",0.39349,1.02,0.417,304,1,"norfloxacin, sparfloxacin, sarafloxacin, lomefloxacin",0.379863945026242,0,FALSE +"A549","Pearson.est","BCL inhibitor",-0.41521,-1.07,0.369,1236,0.618,"TW.37, venetoclax",0.43297363384094,0.209011524911184,FALSE +"A549","Pearson.est","Bcr.Abl kinase inhibitor",0.39623,1.04,0.402,209,1,"bafetinib, flumatinib, GZD824",0.39577394691553,0,FALSE +"A549","Pearson.est","benzodiazepine receptor agonist",0.38078,0.998,0.458,289,0.943,"indiplon, gamma.aminobutyric.acid, CL.218872, bentazepam, temazepam, piperazine",0.339134521996131,0.0254883072626717,FALSE +"A549","Pearson.est","bromodomain inhibitor",0.38627,1.01,0.43,891,0.958,"I.BET151, JQ1...., PFI.1, bromosporine, I.BET.762, OTX015",0.366531544420413,0.0186344909214556,FALSE +"A549","Pearson.est","calcium channel blocker",0.31788,0.825,0.68,275,0.994,"SKF.96365, fendiline, penfluridol",0.167491087293764,0.00261361560268669,FALSE +"A549","Pearson.est","CC chemokine receptor antagonist",-0.26654,-0.705,0.824,1232,0.944,"ZK811752, navarixin",0.0840727883028842,0.025028005701931,FALSE +"A549","Pearson.est","CDK inhibitor",-0.43057,-1.16,0.275,961,0.673,"kenpaullone, PHA.848125, aminopurvalanol.a, indirubin, palbociclib, ribociclib, NU6027, R547, PHA.793887, AZD5438, BMS.265246",0.560667306169737,0.171984935776023,FALSE +"A549","Pearson.est","CHK inhibitor",0.31059,0.799,0.68,311,1,"PF.477736, LY2606368",0.167491087293764,0,FALSE +"A549","Pearson.est","cyclooxygenase inhibitor",0.27019,0.701,0.812,252,1,"naproxen, pterostilbene, FK.3311, phenylbutazone, phenazone",0.0904439707588247,0,FALSE +"A549","Pearson.est","cytochrome P450 inhibitor",0.69324,1.83,0.0157,235,0.313,"morin, itraconazole, metyrapone, clotrimazole",1.80410034759077,0.504455662453552,FALSE +"A549","Pearson.est","DNA alkylating agent",-0.46678,-1.25,0.207,1249,0.553,"cyclophosphamide, TH.302, mitomycin.c, carmustine, streptozotocin, carboplatin",0.684029654543082,0.257274868695302,FALSE +"A549","Pearson.est","DNA inhibitor",-0.50283,-1.32,0.182,1306,0.564,"teroxirone, carmustine, nimorazole, valrubicin, carboplatin",0.739928612014925,0.248720896016658,FALSE +"A549","Pearson.est","DNA methyltransferase inhibitor",-0.36158,-0.955,0.492,1101,0.676,"azacitidine, disulfiram, decitabine",0.30803489723264,0.170053304058364,FALSE +"A549","Pearson.est","DNA polymerase inhibitor",0.34492,0.921,0.536,266,0.894,"famciclovir, cephalomannine",0.27083521030723,0.0486624812040823,FALSE +"A549","Pearson.est","DNA synthesis inhibitor",-0.48177,-1.26,0.213,1191,0.626,"azodicarbonamide, enocitabine, mitomycin.c, cyclocytidine, anisomycin, floxuridine",0.671620396561262,0.20342566678957,FALSE +"A549","Pearson.est","dopamine receptor antagonist",-0.22482,-0.584,0.933,1074,0.96,"UH.232...., remoxipride, acetophenazine, mesoridazine, amisulpride, thioproperazine, oxiperomide",0.0301183562535,0.0177287669604316,FALSE +"A549","Pearson.est","estrogen receptor agonist",-0.39978,-1.02,0.407,968,0.645,"estradiol, ethinyl.estradiol, levonorgestrel, PPT",0.39040559077478,0.190440285364732,FALSE +"A549","Pearson.est","estrogen receptor antagonist",0.58059,1.52,0.0693,199,0.927,"toremifene, fulvestrant, tamoxifen",1.15926676538819,0.0329202658555029,FALSE +"A549","Pearson.est","FGFR inhibitor",0.56175,1.47,0.0959,299,0.907,"erdafitinib, lenvatinib, orantinib, dovitinib, lucitanib",1.01818139282934,0.0423927129399047,FALSE +"A549","Pearson.est","FLT3 inhibitor",0.26289,0.701,0.836,319,1,"gilteritinib, tyrphostin.AG.1296, dovitinib, sorafenib, tandutinib",0.0777937225609836,0,FALSE +"A549","Pearson.est","glucocorticoid receptor agonist",-0.5263,-1.37,0.153,1157,0.655,"prednisolone.acetate, beclomethasone.dipropionate, halobetasol.propionate, rimexolone, prednisolone.hemisuccinate, methylprednisolone, dexamethasone.acetate, desonide, prednisolone, ciclesonide, fluocinolone.acetonide, fludroxycortide",0.815308569182401,0.183758700008217,FALSE +"A549","Pearson.est","glutamate receptor antagonist",0.42371,1.1,0.348,189,1,"kynurenic.acid, JNJ.16259685, LY456236, felbamate",0.458420756053419,0,FALSE +"A549","Pearson.est","glycogen synthase kinase inhibitor",-0.24308,-0.641,0.912,961,0.963,"kenpaullone, tideglusib, LY2090314, indirubin, AZD2858",0.0400051616715838,0.0163737128754655,FALSE +"A549","Pearson.est","growth factor receptor inhibitor",-0.46656,-1.25,0.227,1000,0.553,"PHA.848125, GSK1838705A, AZD3463",0.643974142806877,0.257274868695302,FALSE +"A549","Pearson.est","HCV inhibitor",-0.50051,-1.32,0.165,1446,0.564,"narlaprevir",0.782516055786094,0.248720896016658,FALSE +"A549","Pearson.est","HDAC inhibitor",-0.43884,-1.15,0.297,920,0.61,"dacinostat, R306465, ACY.1215, AR.42, RG2833, panobinostat, trichostatin.a, RGFP966, chidamide, PCI.24781, entinostat, romidepsin, JNJ.26481585, givinostat",0.527243550682788,0.214670164989233,FALSE +"A549","Pearson.est","histamine receptor antagonist",0.3834,0.986,0.461,294,0.856,"chloropyramine, famotidine, lafutidine, ebastine, astemizole, tiotidine",0.336299074610352,0.0675262353228468,FALSE +"A549","Pearson.est","HMGCR inhibitor",-0.31907,-0.848,0.627,981,0.834,"simvastatin, fluvastatin, pitavastatin",0.202732459169284,0.0788339493622613,FALSE +"A549","Pearson.est","HSP inhibitor",-0.56818,-1.51,0.0842,1245,0.497,"SNX.2112, ganetespib, NVP.AUY922, VER.49009, BIIB021, PU.H71, tanespimycin",1.07468790850035,0.303643611266668,FALSE +"A549","Pearson.est","JAK inhibitor",-0.41421,-1.09,0.337,1258,0.614,"pacritinib, WHI.P154, AZ960, filgotinib",0.472370099128661,0.211831628858832,FALSE +"A549","Pearson.est","KIT inhibitor",0.36655,0.933,0.516,93,0.901,"cediranib, lenvatinib, pazopanib",0.287350298372789,0.045275209020937,FALSE +"A549","Pearson.est","MDM inhibitor",-0.70315,-1.87,0.0201,1137,0.376,"nutlin.3, CGM097, RITA, idasanutlin",1.69680394257951,0.424812155072339,FALSE +"A549","Pearson.est","MEK inhibitor",-0.63047,-1.63,0.0427,1332,0.433,"cobimetinib, MEK162, trametinib, PD.0325901, selumetinib, TAK.733, Ro.4987655, AS.703026, PD.318088, refametinib, PD.184352, AZD8330",1.36957212497498,0.363512103646635,FALSE +"A549","Pearson.est","MET inhibitor",-0.53736,-1.4,0.13,1218,0.669,"PF.04217903",0.886056647693163,0.174573882232177,FALSE +"A549","Pearson.est","microtubule inhibitor",0.29374,0.765,0.734,212,1,"colchicine, estramustine.phosphate",0.134303940083929,0,FALSE +"A549","Pearson.est","mTOR inhibitor",-0.72148,-1.86,0.012,1117,0.202,"voxtalisib, PI.103, WYE.354, deforolimus, LY3023414, LY303511, AZD2014, WAY.600, AZD8055, temsirolimus, MLN0128, PP242, GDC.0980, ku.0063794, XL388, torin.1, SB.2343, NVP.BEZ235, sirolimus, everolimus, GSK2126458",1.92081875395238,0.694648630553376,TRUE +"A549","Pearson.est","NFkB pathway inhibitor",0.39684,1.03,0.411,167,1,"parthenolide...., bindarit, tyloxapol",0.386158178123931,0,FALSE +"A549","Pearson.est","opioid receptor agonist",-0.29405,-0.757,0.752,1050,0.926,"BW.180C, cebranopadol, salvinorin.a",0.123782159408358,0.0333890133180656,FALSE +"A549","Pearson.est","p38 MAPK inhibitor",0.61473,1.58,0.0572,205,0.949,"TAK.715, SB.239063, SB.242235",1.24260397120698,0.0227337875727074,FALSE +"A549","Pearson.est","PARP inhibitor",-0.2455,-0.632,0.893,1128,0.944,"olaparib, endo.IWR.1, talazoparib",0.0491485411114536,0.025028005701931,FALSE +"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.22504,0.594,0.933,319,0.988,"lenvatinib, pazopanib, orantinib, dovitinib, sorafenib, tandutinib",0.0301183562535,0.00524305541237188,FALSE +"A549","Pearson.est","phosphatase inhibitor",0.36346,0.951,0.518,443,0.897,"BVT.948, GSK2830371, AS.1949490, CID.5458317, mycophenolate.mofetil, alexidine",0.285670240254767,0.0472075569559079,FALSE +"A549","Pearson.est","phosphodiesterase inhibitor",0.29244,0.769,0.735,29,1,"enoximone",0.133712660915805,0,FALSE +"A549","Pearson.est","PI3K inhibitor",-0.59205,-1.59,0.0471,1083,0.421,"ZSTK.474, voxtalisib, PI.103, CUDC.907, LY3023414, LY303511, alpelisib, TG.100713, pilaralisib, PI3K.IN.2, GDC.0941, taselisib, GDC.0980, CH5132799, YM.201636, SB.2343, NVP.BEZ235, GSK2126458",1.3269790928711,0.375717904164332,FALSE +"A549","Pearson.est","PLK inhibitor",-0.3731,-0.99,0.439,1023,0.668,"NMS.1286937, HMN.214, rigosertib",0.357535479757879,0.175223537524454,FALSE +"A549","Pearson.est","potassium channel blocker",0.40471,1.06,0.372,19,1,"dofetilide",0.429457060118102,0,FALSE +"A549","Pearson.est","PPAR receptor agonist",0.46152,1.22,0.231,225,1,"pterostilbene, S26948, GW.501516",0.636388020107856,0,FALSE +"A549","Pearson.est","progesterone receptor agonist",0.18346,0.486,0.986,1184,1,"nomegestrol.acetate, norethindrone.acetate, dienogest, norethindrone, norgestrel, melengestrol.acetate, danazol, levonorgestrel, tanaproget",0.0061230850587888,0,FALSE +"A549","Pearson.est","proteasome inhibitor",0.48687,1.28,0.204,480,1,"oprozomib, carfilzomib, ONX.0914, bortezomib, MG.132",0.690369832574101,0,FALSE +"A549","Pearson.est","protein synthesis inhibitor",-0.28509,-0.743,0.774,955,0.916,"methacycline, azomycin..2.nitroimidazole., emetine, anguidine, tedizolid.phosphate, brefeldin.a, mercaptopurine, cycloheximide, thiostrepton",0.111259039317107,0.0381045263321496,FALSE +"A549","Pearson.est","protein tyrosine kinase inhibitor",0.25919,0.669,0.868,315,1,"rheochrysidin, PP.121, tyrphostin.A9",0.0614802748235081,0,FALSE +"A549","Pearson.est","RAF inhibitor",0.42989,1.13,0.288,574,1,"GDC.0879, PLX.4720, vemurafenib, sorafenib, SB.590885, regorafenib, LGX818, TAK.632, RAF265",0.540607512240769,0,FALSE +"A549","Pearson.est","RET tyrosine kinase inhibitor",0.35931,0.908,0.545,415,0.86,"sorafenib, apatinib, regorafenib",0.263603497723358,0.0655015487564323,FALSE +"A549","Pearson.est","retinoid receptor agonist",0.46829,1.22,0.223,296,1,"adapalene, fenretinide, AM.580, tamibarotene",0.651695136951839,0,FALSE +"A549","Pearson.est","ribonucleotide reductase inhibitor",0.27399,0.712,0.79,1054,1,"pentostatin, cytarabine, hydroxyurea, fludarabine.phosphate, LY2334737, cladribine, clofarabine, fludarabine, triapine, gemcitabine",0.102372908709559,0,FALSE +"A549","Pearson.est","serotonin receptor agonist",-0.51201,-1.34,0.17,916,0.645,"zolmitriptan, SR.57227A, aripiprazole, ipsapirone",0.769551078621726,0.190440285364732,FALSE +"A549","Pearson.est","serotonin receptor antagonist",0.39403,1.01,0.426,276,0.958,"lerisetron, sertindole, lurasidone, pirenperone, tropisetron",0.370590400897281,0.0186344909214556,FALSE +"A549","Pearson.est","sodium channel blocker",0.43254,1.12,0.318,302,1,"cibenzoline, lappaconite, oxcarbazepine, quinidine, triamterene, benzethonium",0.497572880015567,0,FALSE +"A549","Pearson.est","src inhibitor",0.24809,0.646,0.871,1091,1,"PP.1, bosutinib, ZM.306416, saracatinib, PP.2, TG.100572, dasatinib, masitinib, KX2.391",0.0599818449923368,0,FALSE +"A549","Pearson.est","sterol demethylase inhibitor",0.37216,0.989,0.451,221,0.886,"chlormidazole, terconazole",0.345823458122039,0.0525662781129492,FALSE +"A549","Pearson.est","TGF beta receptor inhibitor",0.35744,0.917,0.563,86,0.87,"LY2109761",0.249491605148654,0.0604807473813815,FALSE +"A549","Pearson.est","thymidylate synthase inhibitor",-0.36725,-0.984,0.436,1297,0.653,"raltitrexed, carmofur",0.360513510731414,0.185086818724926,FALSE +"A549","Pearson.est","topoisomerase inhibitor",-0.2879,-0.762,0.753,1353,0.95,"amsacrine, idarubicin, voreloxin, TAS.103, valrubicin",0.123205023799299,0.0222763947111523,FALSE +"A549","Pearson.est","tubulin polymerization inhibitor",0.18483,0.477,0.993,396,0.985,"indibulin, vinorelbine, vincristine, paclitaxel, vindesine, nocodazole, ABT.751, fenbendazole",0.00305075150461883,0.00656376950238827,FALSE +"A549","Pearson.est","tyrosine kinase inhibitor",0.22787,0.583,0.934,336,0.975,"bafetinib, rheochrysidin, tivantinib, PP.121, sorafenib, tyrphostin.A9, apatinib",0.0296531237699066,0.0109953843014632,FALSE +"A549","Pearson.est","VEGFR inhibitor",0.23853,0.619,0.902,149,0.988,"cediranib, lenvatinib, pazopanib, SAR131675, orantinib",0.0447934624580583,0.00524305541237188,FALSE +"A549","Pearson.est","vitamin D receptor agonist",-0.40168,-1.05,0.376,986,0.623,"calcitriol, alfacalcidol, ercalcitriol, tacalcitol",0.424812155072339,0.20551195334083,FALSE +"H1703","Pearson.est","EGFR inhibitor",0.43321,1.11,0.317,376,0.849,"tyrphostin.AG.1478, WZ8040, BIBX.1382, OSI.420, tyrphostin.AG.494, CGP.52411, BIBU.1361, icotinib, gefitinib, erlotinib, dacomitinib, AZD8931, PD.153035, canertinib, pelitinib, CP.724714, osimertinib, BMS.690514, tucatinib",0.498940737782249,0.0710923097560473,FALSE +"H1703","Pearson.est","Abl kinase inhibitor",0.29464,0.754,0.768,11,0.907,"imatinib",0.114638779968488,0.0423927129399047,FALSE +"H1703","Pearson.est","acetylcholine receptor agonist",0.36287,0.935,0.512,423,1,"nefiracetam, nicotine, oxiracetam",0.290730039024169,0,FALSE +"H1703","Pearson.est","acetylcholine receptor antagonist",-0.27996,-0.738,0.747,1025,0.922,"methscopolamine, hyoscyamine, iododexetimide",0.126679398184601,0.0352690789463706,FALSE +"H1703","Pearson.est","adenosine receptor antagonist",0.62421,1.58,0.0529,222,0.732,"MRS.1220, CGS.15943, SCH.58261, PSB.1115",1.27654432796481,0.135488918941608,FALSE +"H1703","Pearson.est","adrenergic receptor agonist",0.3297,0.858,0.63,295,1,"oxymetazoline, clenbuterol, lidamidine, isoxsuprine",0.200659450546418,0,FALSE +"H1703","Pearson.est","adrenergic receptor antagonist",-0.27192,-0.726,0.771,1178,0.903,"vincamine, prazosin, carvedilol, practolol, naftidrofuryl, dihydroergocristine",0.112945621949043,0.0443122496864942,FALSE +"H1703","Pearson.est","AKT inhibitor",0.61667,1.54,0.0729,210,0.723,"uprosertib, CCT128930, AZD5363, palomid.529, triciribine, GDC.0068",1.13727247168203,0.140861702705469,FALSE +"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.26542,0.689,0.854,357,0.918,"GW.788388, SB.505124, alectinib, NVP.TAE684",0.068542129310995,0.0371573187987575,FALSE +"H1703","Pearson.est","androgen receptor antagonist",-0.31247,-0.838,0.646,1396,0.874,"flutamide",0.189767482004916,0.058488567365597,FALSE +"H1703","Pearson.est","antioxidant",0.50091,1.27,0.202,458,0.674,"benfotiamine, mesna, chlorogenic.acid, taurine",0.694648630553376,0.17134010346468,FALSE +"H1703","Pearson.est","AP inhibitor",-0.35381,-0.941,0.511,1417,0.904,"idronoxil",0.291579099865287,0.0438315695246367,FALSE +"H1703","Pearson.est","ATPase inhibitor",-0.51611,-1.4,0.124,1428,0.544,"k.strophanthidin, oligomycin.a",0.906578314837765,0.26440110030182,FALSE +"H1703","Pearson.est","Aurora kinase inhibitor",0.32019,0.817,0.689,413,1,"MLN.8054, barasertib, GSK1070916, ENMD.2076, KW.2449, PF.03814735, MK.8745, tozasertib",0.161780778092374,0,FALSE +"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.35201,-0.942,0.502,1367,0.962,"azithromycin, josamycin",0.299296282854981,0.0168249279621871,FALSE +"H1703","Pearson.est","bacterial DNA gyrase inhibitor",-0.32693,-0.885,0.571,1269,0.87,"norfloxacin, lomefloxacin, sparfloxacin",0.243363891754152,0.0604807473813815,FALSE +"H1703","Pearson.est","BCL inhibitor",0.36572,0.932,0.529,446,0.946,"venetoclax, oridonin, obatoclax, HA14.1, navitoclax",0.276544327964814,0.0241088635982073,FALSE +"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.36819,0.932,0.528,11,0.946,"imatinib",0.277366077466188,0.0241088635982073,FALSE +"H1703","Pearson.est","benzodiazepine receptor agonist",0.3132,0.814,0.688,359,1,"nefiracetam, lorazepam, CGS.20625, zaleplon, eprinomectin, ivermectin",0.162411561764489,0,FALSE +"H1703","Pearson.est","bromodomain inhibitor",-0.4287,-1.08,0.368,1413,0.84,"PFI.1",0.434152181326482,0.0757207139381184,FALSE +"H1703","Pearson.est","calcium channel blocker",0.28288,0.727,0.8,311,0.907,"cinnarazine, efonidipine.monoethanolate, pranidipine, SR.33805",0.0969100130080564,0.0423927129399047,FALSE +"H1703","Pearson.est","CC chemokine receptor antagonist",-0.30035,-0.799,0.691,1255,0.862,"MK.0812, UNBS.5162",0.160521952625802,0.0644927341752872,FALSE +"H1703","Pearson.est","CDK inhibitor",0.42243,1.06,0.399,299,0.931,"indirubin, AZD5438, TG.02, alvocidib, JNJ.7706621, kenpaullone, palbociclib, P276.00, PHA.793887",0.399027104313252,0.0310503190186574,FALSE +"H1703","Pearson.est","CHK inhibitor",0.21284,0.534,0.965,141,1,"SCH.900776",0.0154726866562074,0,FALSE +"H1703","Pearson.est","cyclooxygenase inhibitor",0.29621,0.752,0.756,352,0.891,"tryptanthrin, FR.122047, amfenac, aspirin, curcumin, phenylbutazone",0.121478204498793,0.0501222959631252,FALSE +"H1703","Pearson.est","cytochrome P450 inhibitor",0.47405,1.21,0.252,64,0.77,"PF.4981517, itraconazole",0.598599459218456,0.113509274827518,FALSE +"H1703","Pearson.est","DNA alkylating agent",-0.24955,-0.668,0.855,1362,0.912,"mitomycin.c, dianhydrogalactitol",0.0680338852718274,0.0400051616715838,FALSE +"H1703","Pearson.est","DNA inhibitor",0.31127,0.782,0.705,54,0.998,"busulfan, nithiamide",0.151810883008601,0.000869458712628891,FALSE +"H1703","Pearson.est","DNA methyltransferase inhibitor",0.53115,1.38,0.128,396,1,"azacitidine, fdcyd, decitabine",0.892790030352132,0,FALSE +"H1703","Pearson.est","DNA polymerase inhibitor",0.4446,1.14,0.289,626,0.907,"famciclovir, foscarnet, cidofovir, idoxuridine, menadione, adefovir.dipivoxil",0.539102157243452,0.0423927129399047,FALSE +"H1703","Pearson.est","DNA synthesis inhibitor",-0.3046,-0.832,0.634,1114,0.845,"artemisinin, enocitabine, nelarabine, azodicarbonamide, mitomycin.c, artesunate",0.197910742118267,0.0731432910503077,FALSE +"H1703","Pearson.est","dopamine receptor antagonist",0.50365,1.29,0.176,314,0.721,"acetophenazine, mesoridazine, domperidone, ziprasidone, UH.232...., oxiperomide, remoxipride, clebopride",0.75448733218585,0.142064735280571,FALSE +"H1703","Pearson.est","estrogen receptor agonist",-0.2647,-0.712,0.795,1104,0.888,"estradiol.cypionate, levonorgestrel",0.0996328713435297,0.051587034221399,FALSE +"H1703","Pearson.est","estrogen receptor antagonist",-0.70779,-1.93,0.00959,1100,0.302,"raloxifene, fulvestrant, clomifene, toremifene",2.01818139282934,0.519993057042849,FALSE +"H1703","Pearson.est","FGFR inhibitor",-0.34041,-0.901,0.549,1238,0.939,"dovitinib, regorafenib, erdafitinib",0.260427655549908,0.0273344077338891,FALSE +"H1703","Pearson.est","FLT3 inhibitor",0.35513,0.899,0.549,413,0.96,"sunitinib, TG.02, tandutinib, pacritinib, ENMD.2076, lestaurtinib, GTP.14564, KW.2449, tozasertib",0.260427655549908,0.0177287669604316,FALSE +"H1703","Pearson.est","glucocorticoid receptor agonist",-0.40874,-1.08,0.367,934,0.84,"rimexolone, prednisolone.acetate, ciclesonide, halcinonide, halobetasol.propionate, beclomethasone.dipropionate, triamcinolone, methylprednisolone, fluticasone.propionate, prednisolone.hemisuccinate, triamcinolone.acetonide, flumethasone.pivalate, betamethasone, fluorometholone, clobetasol.propionate, deflazacort",0.435333935747911,0.0757207139381184,FALSE +"H1703","Pearson.est","glutamate receptor antagonist",0.39429,0.986,0.473,105,0.994,"diazooxonorleucine, SIB.1757, latrepirdine",0.325138859262188,0.00261361560268669,FALSE +"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.41632,1.04,0.386,524,0.899,"indirubin, CHIR.99021, GSK.3.inhibitor.IX, kenpaullone, LY2090314, tideglusib, CHIR.98014",0.413412695328245,0.0462403082667712,FALSE +"H1703","Pearson.est","growth factor receptor inhibitor",0.2569,0.661,0.869,491,0.932,"GSK1904529A, lestaurtinib, GSK1838705A",0.0609802235513335,0.0305840876460186,FALSE +"H1703","Pearson.est","HCV inhibitor",0.51867,1.34,0.158,116,0.769,"daclatasvir, PSI.7976",0.801342913045577,0.114073660198569,FALSE +"H1703","Pearson.est","HDAC inhibitor",0.44742,1.13,0.315,404,0.887,"tacedinaline, R306465, vorinostat, romidepsin, pyroxamide, JNJ.26481585, panobinostat, resminostat, belinostat, ACY.1215, RG2833, RGFP966",0.501689446210399,0.0520763801682736,FALSE +"H1703","Pearson.est","histamine receptor antagonist",0.38336,0.985,0.467,110,0.958,"levocetirizine, ranitidine, terfenadine",0.330683119433888,0.0186344909214556,FALSE +"H1703","Pearson.est","HMGCR inhibitor",-0.6792,-1.79,0.0268,1126,0.23,"fluvastatin, atorvastatin, mevastatin, pitavastatin",1.57186520597121,0.638272163982407,TRUE +"H1703","Pearson.est","HSP inhibitor",0.56801,1.47,0.103,514,0.846,"guanidine, KW.2478, PU.H71, BIIB021, SNX.5422, NVP.AUY922, XL888, tanespimycin, VER.49009",0.987162775294828,0.0726296369609765,FALSE +"H1703","Pearson.est","JAK inhibitor",0.37795,0.95,0.513,329,1,"TG.02, atiprimod, pacritinib, filgotinib, CEP.33779, lestaurtinib",0.289882634888184,0,FALSE +"H1703","Pearson.est","KIT inhibitor",0.4965,1.27,0.193,219,0.674,"imatinib, sunitinib, tandutinib, KI.8751, OSI.930",0.714442690992226,0.17134010346468,FALSE +"H1703","Pearson.est","MDM inhibitor",0.5189,1.33,0.153,170,0.732,"nutlin.3, CGM097",0.815308569182401,0.135488918941608,FALSE +"H1703","Pearson.est","MEK inhibitor",0.72377,1.87,0.012,145,0.427,"trametinib, AS.703026, PD.0325901, cobimetinib, MEK162, Ro.4987655, TAK.733, refametinib, AZD8330, selumetinib, PD.198306, PD.184352",1.92081875395238,0.369572124974976,FALSE +"H1703","Pearson.est","MET inhibitor",-0.36893,-0.973,0.458,532,1,"PF.04217903, INC.280, AMG458, NVP.BVU972, LY2801653, PHA.665752",0.339134521996131,0,FALSE +"H1703","Pearson.est","microtubule inhibitor",-0.36666,-0.965,0.471,1204,0.976,"secnidazole, cabazitaxel, D.64131",0.326979092871104,0.0105501823333082,FALSE +"H1703","Pearson.est","mTOR inhibitor",0.18812,0.48,0.985,438,0.984,"PP242, palomid.529, GSK2126458, LY303511, XL388, WAY.600, torin.2, OSI.027, PF.05212384",0.00656376950238827,0.00700490156865849,FALSE +"H1703","Pearson.est","NFkB pathway inhibitor",0.25545,0.656,0.874,467,0.919,"betulinic.acid, bortezomib, curcumin, bindarit, IKK.2.inhibitor.V",0.058488567365597,0.0366844886138887,FALSE +"H1703","Pearson.est","opioid receptor agonist",0.68912,1.76,0.0168,392,0.482,"salvinorin.a, BW.180C, cebranopadol",1.77469071827414,0.31695296176115,FALSE +"H1703","Pearson.est","p38 MAPK inhibitor",0.29923,0.756,0.726,234,0.925,"CMPD.1, skepinone.l",0.139063379299906,0.0338582672609674,FALSE +"H1703","Pearson.est","PARP inhibitor",0.32398,0.807,0.692,493,1,"PJ.34, talazoparib, endo.IWR.1, AG.14361",0.159893905543242,0,FALSE +"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.30912,0.78,0.725,520,0.977,"imatinib, sunitinib, tandutinib, KI.8751, SU014813, linifanib, orantinib, motesanib, axitinib, crenolanib, CP.673451",0.139661993429006,0.0101054362812269,FALSE +"H1703","Pearson.est","phosphatase inhibitor",-0.32589,-0.885,0.574,1107,0.87,"CID.5458317, AS.1949490, bis.maltolato.oxovanadium.IV., GSK2830371",0.241088107602027,0.0604807473813815,FALSE +"H1703","Pearson.est","phosphodiesterase inhibitor",0.32019,0.792,0.685,321,1,"cilostamide, anagrelide, zardaverine",0.164309428507574,0,FALSE +"H1703","Pearson.est","PI3K inhibitor",0.31593,0.799,0.705,216,1,"CH5132799, CUDC.907, alpelisib, TG.100713, GSK2126458, TG100.115, LY303511",0.151810883008601,0,FALSE +"H1703","Pearson.est","PLK inhibitor",-0.70766,-1.86,0.0221,1247,0.23,"NMS.1286937, volasertib, BI.2536, GSK461364",1.65560772631489,0.638272163982407,TRUE +"H1703","Pearson.est","potassium channel blocker",0.52165,1.35,0.145,254,0.908,"oleoylethanolamide, meglitinide",0.838631997765025,0.0419141514789149,FALSE +"H1703","Pearson.est","PPAR receptor agonist",0.52062,1.34,0.16,100,0.769,"oleoylethanolamide, S26948",0.795880017344075,0.114073660198569,FALSE +"H1703","Pearson.est","progesterone receptor agonist",-0.43244,-1.17,0.277,990,0.873,"melengestrol.acetate, norethindrone, norgestrel, levonorgestrel, nomegestrol.acetate",0.557520230935551,0.0589857562944303,FALSE +"H1703","Pearson.est","proteasome inhibitor",0.35968,0.922,0.529,547,0.938,"ixazomib.citrate, bortezomib, ixazomib, MG.132, carfilzomib, oprozomib",0.276544327964814,0.0277971616209356,FALSE +"H1703","Pearson.est","protein synthesis inhibitor",-0.31218,-0.838,0.635,1264,0.874,"harringtonine, puromycin, clofoctol, mercaptopurine, anguidine",0.197226274708024,0.058488567365597,FALSE +"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.44191,-1.2,0.225,1309,0.902,"tyrphostin.A9, rheochrysidin, mubritinib",0.647817481888638,0.0447934624580583,FALSE +"H1703","Pearson.est","RAF inhibitor",0.3051,0.772,0.753,178,0.967,"AZ.628, dabrafenib, CEP.32496",0.123205023799299,0.0145735259169983,FALSE +"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.41025,1.05,0.381,275,0.915,"sunitinib, apatinib",0.419075024324381,0.0385789059335517,FALSE +"H1703","Pearson.est","retinoid receptor agonist",-0.42994,-1.16,0.271,1205,0.807,"adapalene, LE.135, AM.580, bexarotene, fenretinide",0.567030709125594,0.0931264652779296,FALSE +"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.61188,-1.67,0.0536,1237,0.215,"gemcitabine, cladribine, fludarabine, clofarabine, pentostatin",1.27083521030723,0.667561540084395,FALSE +"H1703","Pearson.est","serotonin receptor agonist",0.64049,1.64,0.0339,32,0.7,"aripiprazole, ipsapirone",1.46980030179692,0.154901959985743,FALSE +"H1703","Pearson.est","serotonin receptor antagonist",0.51339,1.31,0.187,330,0.725,"aripiprazole, ziprasidone, SB.228357, RS.16566, tropisetron",0.728158393463501,0.139661993429006,FALSE +"H1703","Pearson.est","sodium channel blocker",0.29577,0.769,0.74,383,0.949,"A.803467, ajmaline, lappaconite, benzethonium, triamterene, brivaracetam",0.130768280269024,0.0227337875727074,FALSE +"H1703","Pearson.est","src inhibitor",-0.18581,-0.505,0.98,1188,0.978,"ZM.306416, TG.100572",0.00877392430750515,0.00966114521239857,FALSE +"H1703","Pearson.est","sterol demethylase inhibitor",-0.60734,-1.67,0.0508,950,0.215,"sulconazole, ketoconazole, chlormidazole, posaconazole, lanoconazole",1.29413628771608,0.667561540084395,FALSE +"H1703","Pearson.est","TGF beta receptor inhibitor",0.53509,1.35,0.136,401,0.908,"LY2109761, D.4476, repsox, SB.431542",0.866461091629782,0.0419141514789149,FALSE +"H1703","Pearson.est","thymidylate synthase inhibitor",0.30049,0.765,0.749,419,0.933,"carmofur, capecitabine, raltitrexed",0.125518182300534,0.0301183562535,FALSE +"H1703","Pearson.est","topoisomerase inhibitor",-0.64092,-1.75,0.0259,1139,0.219,"voreloxin, exatecan.mesylate, daunorubicin, valrubicin, teniposide, nemorubicin, amonafide, etoposide, idarubicin, TAS.103, dexrazoxane, licochalcone.a, doxorubicin, amsacrine, etoposide.phosphate, epirubicin, mitoxantrone",1.58670023591875,0.659555885159882,TRUE +"H1703","Pearson.est","tubulin polymerization inhibitor",-0.21559,-0.583,0.938,873,0.966,"nocodazole, BNC105, parbendazole, podophyllotoxin, flubendazole, KX2.391, mebendazole, vincristine, oxibendazole, ABT.751, epothilone.b, dolastatin.10, fenbendazole, CYT.997",0.0277971616209356,0.0150228735845067,FALSE +"H1703","Pearson.est","tyrosine kinase inhibitor",0.19389,0.501,0.984,317,0.996,"sunitinib, UNC2250, tivantinib, apatinib, NVP.TAE226, CP.724714",0.00700490156865849,0.00174066157630127,FALSE +"H1703","Pearson.est","VEGFR inhibitor",0.27579,0.701,0.803,358,0.923,"MGCD.265, sunitinib, semaxanib, KI.8751, PD.173074, OSI.930, SU014813, ENMD.2076, linifanib, orantinib, BMS.690514",0.095284454721319,0.0347982989740879,FALSE +"H1703","Pearson.est","vitamin D receptor agonist",0.4427,1.11,0.319,107,0.849,"calcitriol, ercalcitriol",0.496209316942819,0.0710923097560473,FALSE +"HCC15","Pearson.est","EGFR inhibitor",0.21964,0.54,0.963,281,0.987,"CUDC.101, BIBX.1382, tucatinib, FERb.033, tyrphostin.AG.494, gefitinib, canertinib, BMS.690514",0.0163737128754655,0.00568284733036327,FALSE +"HCC15","Pearson.est","Abl kinase inhibitor",-0.49591,-1.26,0.21,1240,0.878,"bafetinib, metatinib, dasatinib, ponatinib",0.677780705266081,0.0565054840938974,FALSE +"HCC15","Pearson.est","acetylcholine receptor agonist",0.49011,1.22,0.245,690,0.746,"nicotine, xanomeline, oxiracetam, nefiracetam, tremorine",0.610833915635468,0.127261172527331,FALSE +"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.64387,-1.67,0.0438,1326,1,"hyoscyamine, diphemanil",1.3585258894959,0,FALSE +"HCC15","Pearson.est","adenosine receptor antagonist",-0.44275,-1.17,0.243,1434,0.869,"theophylline",0.614393726401688,0.0609802235513335,FALSE +"HCC15","Pearson.est","adrenergic receptor agonist",-0.27365,-0.72,0.76,1415,0.86,"A61603, norepinephrine",0.119186407719209,0.0655015487564323,FALSE +"HCC15","Pearson.est","adrenergic receptor antagonist",-0.35113,-0.937,0.496,1280,0.857,"idazoxan, practolol, naftidrofuryl, carvedilol, dihydroergocristine, metoprolol",0.304518323509803,0.0670191780768018,FALSE +"HCC15","Pearson.est","AKT inhibitor",0.54041,1.35,0.144,34,0.814,"uprosertib, GDC.0068, AZD5363",0.84163750790475,0.0893755951107988,FALSE +"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.39133,0.95,0.5,302,0.743,"SB.505124, alectinib, GW.788388, DMH1",0.301029995663981,0.129011186239425,FALSE +"HCC15","Pearson.est","androgen receptor antagonist",-0.37911,-1.02,0.393,1231,0.939,"flutamide, enzalutamide, cyproterone.acetate",0.405607449624573,0.0273344077338891,FALSE +"HCC15","Pearson.est","antioxidant",0.30934,0.751,0.75,139,0.861,"benfotiamine",0.1249387366083,0.0649968485463452,FALSE +"HCC15","Pearson.est","AP inhibitor",0.22684,0.552,0.954,465,1,"embelin, birinapant",0.0204516252959049,0,FALSE +"HCC15","Pearson.est","ATPase inhibitor",0.47086,1.19,0.249,345,0.768,"k.strophanthidin, thonzonium, digoxin, omeprazole, NMS.873",0.603800652904264,0.114638779968488,FALSE +"HCC15","Pearson.est","Aurora kinase inhibitor",0.3074,0.76,0.747,307,0.871,"barasertib, aurora.a.inhibitor.i, ENMD.2076, alisertib, AMG900, tozasertib, CCT137690, MK.8745",0.126679398184601,0.0599818449923368,FALSE +"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.38528,0.968,0.481,330,0.764,"azalomycin.b, tedizolid, tilmicosin",0.317854923626168,0.11690664142431,FALSE +"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.53163,1.34,0.139,505,0.752,"norfloxacin, sarafloxacin, finafloxacin, lomefloxacin, trovafloxacin, novobiocin",0.856985199745905,0.123782159408358,FALSE +"HCC15","Pearson.est","BCL inhibitor",0.42198,1.05,0.398,397,0.692,"oridonin, venetoclax, gossypol, HA14.1",0.400116927926312,0.159893905543242,FALSE +"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",-0.54543,-1.4,0.128,1240,0.987,"bafetinib, metatinib, dasatinib, ponatinib",0.892790030352132,0.00568284733036327,FALSE +"HCC15","Pearson.est","benzodiazepine receptor agonist",-0.28558,-0.745,0.741,939,0.873,"eprinomectin, ivermectin, ZK.93423, piperazine, bentazepam, temazepam, gamma.aminobutyric.acid, indiplon",0.130181792020672,0.0589857562944303,FALSE +"HCC15","Pearson.est","bromodomain inhibitor",0.46018,1.13,0.303,56,0.691,"JQ1...., I.BET151",0.518557371497695,0.160521952625802,FALSE +"HCC15","Pearson.est","calcium channel blocker",0.47579,1.17,0.259,270,0.681,"SR.33805, tetrandrine, mibefradil, SKF.96365, cinnarazine",0.586700235918748,0.166852888087215,FALSE +"HCC15","Pearson.est","CC chemokine receptor antagonist",-0.30124,-0.788,0.71,1416,0.881,"UNBS.5162",0.148741651280925,0.0550240915879521,FALSE +"HCC15","Pearson.est","CDK inhibitor",0.3808,0.941,0.514,114,0.735,"AZD5438, JNJ.7706621, TG.02, R547",0.289036881004724,0.133712660915805,FALSE +"HCC15","Pearson.est","CHK inhibitor",-0.43832,-1.14,0.285,1147,0.88,"AZD7762, CHIR.124, LY2606368",0.54515513999149,0.0555173278498314,FALSE +"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.29296,-0.764,0.746,1097,0.894,"metoxibutropate, acetylsalicylsalicylic.acid, FK.3311, suxibuzone, ramifenazone, AM.404, indoprofen",0.127261172527331,0.0486624812040823,FALSE +"HCC15","Pearson.est","cytochrome P450 inhibitor",0.47248,1.18,0.251,126,0.743,"itraconazole",0.600326278518962,0.129011186239425,FALSE +"HCC15","Pearson.est","DNA alkylating agent",-0.3599,-0.95,0.494,1339,0.869,"streptozotocin, mitomycin.c, dianhydrogalactitol",0.306273051076353,0.0609802235513335,FALSE +"HCC15","Pearson.est","DNA inhibitor",-0.27467,-0.72,0.786,1218,0.86,"bendamustine, carboplatin, mechlorethamine, teroxirone, tirapazamine",0.104577453960592,0.0655015487564323,FALSE +"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.53013,1.31,0.165,401,0.762,"azacitidine, decitabine, SGI.1027, fdcyd",0.782516055786094,0.1180450286604,FALSE +"HCC15","Pearson.est","DNA polymerase inhibitor",0.6005,1.49,0.077,448,0.577,"trifluridine, cidofovir, adefovir.dipivoxil, cephalomannine, menadione",1.11350927482752,0.238824186844269,FALSE +"HCC15","Pearson.est","DNA synthesis inhibitor",-0.42695,-1.08,0.329,1023,0.907,"enocitabine, floxuridine, cisplatin, artesunate, altretamine, nelarabine, estramustine.phosphate, mitomycin.c",0.482804102050026,0.0423927129399047,FALSE +"HCC15","Pearson.est","dopamine receptor antagonist",0.44334,1.14,0.308,166,0.707,"mesoridazine, raclopride, ziprasidone, clebopride, domperidone",0.511449283499556,0.150580586203101,FALSE +"HCC15","Pearson.est","estrogen receptor agonist",-0.49485,-1.26,0.21,1301,0.878,"levonorgestrel, estradiol.cypionate, equol",0.677780705266081,0.0565054840938974,FALSE +"HCC15","Pearson.est","estrogen receptor antagonist",-0.48024,-1.23,0.234,1116,0.791,"danazol, fulvestrant, toremifene",0.630784142589857,0.101823516502323,FALSE +"HCC15","Pearson.est","FGFR inhibitor",0.4842,1.17,0.283,133,0.681,"lucitanib, nintedanib",0.54821356447571,0.166852888087215,FALSE +"HCC15","Pearson.est","FLT3 inhibitor",0.34022,0.828,0.686,422,0.858,"sorafenib, TG.02, ENMD.2076, tozasertib, sunitinib, tandutinib",0.163675884293248,0.0665127121512946,FALSE +"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.38592,-1.01,0.434,1124,0.863,"triamcinolone, flumethasone.pivalate, fluticasone.propionate, flumethasone, methylprednisolone, beclomethasone.dipropionate, rimexolone, betamethasone, deflazacort, fluorometholone, clobetasol.propionate",0.362510270487489,0.0639892042847904,FALSE +"HCC15","Pearson.est","glutamate receptor antagonist",-0.39969,-1.03,0.404,1095,0.974,"kynurenic.acid, CGP.37849, tiletamine, CPP, MTPG, LY456236",0.393618634889395,0.0114410431213845,FALSE +"HCC15","Pearson.est","glycogen synthase kinase inhibitor",0.22886,0.558,0.959,592,1,"CHIR.99021, tideglusib, GSK.3.inhibitor.IX, indirubin, kenpaullone",0.0181813928293364,0,FALSE +"HCC15","Pearson.est","growth factor receptor inhibitor",-0.35286,-0.902,0.559,1253,0.894,"PHA.848125, GW.441756",0.252588192113577,0.0486624812040823,FALSE +"HCC15","Pearson.est","HCV inhibitor",0.44357,1.1,0.355,392,0.684,"narlaprevir, embelin, daclatasvir",0.449771646944906,0.164943898279884,FALSE +"HCC15","Pearson.est","HDAC inhibitor",0.37552,0.936,0.536,369,0.7,"R306465, RGFP966, pyroxamide, ACY.1215, vorinostat, belinostat, romidepsin, PCI.24781, trichostatin.a",0.27083521030723,0.154901959985743,FALSE +"HCC15","Pearson.est","histamine receptor antagonist",-0.31356,-0.79,0.709,1118,0.908,"lafutidine, tiotidine, astemizole, terfenadine, BF2.649, zolantidine",0.149353764816933,0.0419141514789149,FALSE +"HCC15","Pearson.est","HMGCR inhibitor",-0.23041,-0.623,0.915,1081,0.904,"fluvastatin, mevastatin, pitavastatin",0.0385789059335517,0.0438315695246367,FALSE +"HCC15","Pearson.est","HSP inhibitor",0.50939,1.24,0.211,346,0.75,"NMS.E973, guanidine, KW.2478, BIIB021, PU.H71, NVP.AUY922, SNX.2112",0.675717544702307,0.1249387366083,FALSE +"HCC15","Pearson.est","JAK inhibitor",0.31681,0.774,0.746,325,0.874,"atiprimod, TG.02, tozasertib, filgotinib, AZD1480",0.127261172527331,0.058488567365597,FALSE +"HCC15","Pearson.est","KIT inhibitor",0.43297,1.07,0.381,595,0.713,"sorafenib, OSI.930, telatinib, cediranib, sunitinib, KI.8751, tandutinib, lenvatinib, masitinib, regorafenib, imatinib",0.419075024324381,0.146910470148134,FALSE +"HCC15","Pearson.est","MDM inhibitor",-0.56283,-1.5,0.0802,1182,1,"RITA, AMG.232, idasanutlin",1.09582563171584,0,FALSE +"HCC15","Pearson.est","MEK inhibitor",0.42372,1.04,0.401,387,0.683,"MEK162, AZD8330, TAK.733, PD.0325901, cobimetinib, PD.318088, Ro.4987655, trametinib, AS.703026",0.396855627379818,0.165579296318467,FALSE +"HCC15","Pearson.est","MET inhibitor",-0.37895,-0.979,0.463,1017,0.846,"PF.04217903, LY2801653, NVP.BVU972, PHA.665752",0.334419008982047,0.0726296369609765,FALSE +"HCC15","Pearson.est","microtubule inhibitor",0.38626,0.963,0.489,313,0.747,"vinblastine, vinflunine, podophyllotoxin",0.31069114087638,0.126679398184601,FALSE +"HCC15","Pearson.est","mTOR inhibitor",-0.34263,-0.896,0.558,1174,0.871,"WYE.125132, PI.103, temsirolimus, everolimus, NVP.BEZ235, MLN0128, GDC.0980, SB.2343, deforolimus",0.253365801062421,0.0599818449923368,FALSE +"HCC15","Pearson.est","NFkB pathway inhibitor",0.66576,1.64,0.0389,191,0.379,"betulinic.acid, curcumin, bortezomib, IKK.2.inhibitor.V, parthenolide....",1.41005039867429,0.421360790031928,FALSE +"HCC15","Pearson.est","opioid receptor agonist",0.7326,1.83,0.0067,271,0.185,"salvinorin.a, cebranopadol, trimebutine",2.17392519729917,0.732828271596986,TRUE +"HCC15","Pearson.est","p38 MAPK inhibitor",0.61871,1.53,0.0665,272,0.562,"CMPD.1, TAK.715, skepinone.l",1.1771783546969,0.250263684430939,FALSE +"HCC15","Pearson.est","PARP inhibitor",-0.26042,-0.668,0.852,375,0.879,"PJ.34, niraparib, E7449, talazoparib, AG.14361, olaparib, AZD2461, endo.IWR.1",0.0695604052332999,0.0560111249262281,FALSE +"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.3807,0.938,0.526,595,0.718,"sorafenib, telatinib, CP.673451, nintedanib, crenolanib, sunitinib, KI.8751, tandutinib, linifanib, lenvatinib, SU014813, masitinib, axitinib, regorafenib, imatinib",0.279014255846261,0.1438755557577,FALSE +"HCC15","Pearson.est","phosphatase inhibitor",0.32822,0.822,0.641,460,0.843,"alexidine, CID.5458317, menadione, mycophenolic.acid",0.193141970481183,0.0741724253752577,FALSE +"HCC15","Pearson.est","phosphodiesterase inhibitor",-0.38338,-0.998,0.449,1154,0.846,"GSK256066, YM.976, trequinsin",0.347753658996677,0.0726296369609765,FALSE +"HCC15","Pearson.est","PI3K inhibitor",0.25348,0.628,0.876,109,0.988,"CH5132799, buparlisib, CUDC.907, pilaralisib",0.0574958938319193,0.00524305541237188,FALSE +"HCC15","Pearson.est","PLK inhibitor",-0.52063,-1.35,0.175,1369,0.975,"BI.2536, GSK461364",0.756961951313706,0.0109953843014632,FALSE +"HCC15","Pearson.est","potassium channel blocker",-0.25817,-0.67,0.841,1349,0.9,"ibutilide",0.0752040042020878,0.0457574905606751,FALSE +"HCC15","Pearson.est","PPAR receptor agonist",-0.29981,-0.76,0.749,1099,0.873,"clofibrate, fenofibrate, ciprofibrate",0.125518182300534,0.0589857562944303,FALSE +"HCC15","Pearson.est","progesterone receptor agonist",-0.33383,-0.867,0.608,1116,0.861,"danazol, norethindrone.acetate, dienogest, levonorgestrel, nomegestrol.acetate",0.216096420727265,0.0649968485463452,FALSE +"HCC15","Pearson.est","proteasome inhibitor",0.7039,1.71,0.0186,342,0.306,"MG.132, bortezomib, ixazomib.citrate, oprozomib, ixazomib, carfilzomib",1.73048705578208,0.51427857351842,FALSE +"HCC15","Pearson.est","protein synthesis inhibitor",-0.3392,-0.871,0.583,1328,0.887,"anguidine, clindamycin.phosphate, homoharringtonine, clofoctol, mercaptopurine",0.234331445240986,0.0520763801682736,FALSE +"HCC15","Pearson.est","protein tyrosine kinase inhibitor",-0.30972,-0.812,0.695,446,0.901,"NVP.TAE226, tyrphostin.A9, mubritinib, PP.121, BMS.599626, CP.724714, rheochrysidin, AV.412",0.158015195409886,0.045275209020937,FALSE +"HCC15","Pearson.est","RAF inhibitor",0.52199,1.29,0.182,160,0.746,"SB.590885, sorafenib, dabrafenib, RAF265",0.739928612014925,0.127261172527331,FALSE +"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.50687,1.26,0.213,366,0.76,"sorafenib, apatinib, sunitinib",0.671620396561262,0.119186407719209,FALSE +"HCC15","Pearson.est","retinoid receptor agonist",-0.48294,-1.27,0.209,1344,1,"AM.580, LE.135, bexarotene",0.679853713888946,0,FALSE +"HCC15","Pearson.est","ribonucleotide reductase inhibitor",-0.59003,-1.54,0.0871,1266,1,"gemcitabine, pentostatin, cladribine, fludarabine, clofarabine",1.05998184499234,0,FALSE +"HCC15","Pearson.est","serotonin receptor agonist",0.42785,1.06,0.382,297,0.703,"ipsapirone, zolmitriptan, SR.57227A, pardoprunox",0.417936637088291,0.153044674980176,FALSE +"HCC15","Pearson.est","serotonin receptor antagonist",0.45498,1.12,0.331,108,0.677,"ziprasidone, lerisetron, tropisetron, pirenperone",0.480172006224281,0.169411331314856,FALSE +"HCC15","Pearson.est","sodium channel blocker",0.17621,0.437,0.998,634,0.995,"benzocaine, brivaracetam, ajmaline, A.803467, mexiletine, triamterene, lappaconite, benzethonium",0.000869458712628891,0.00217691925427455,FALSE +"HCC15","Pearson.est","src inhibitor",-0.41442,-1.09,0.333,1008,0.945,"saracatinib, PP.1, TG.100572, dasatinib",0.47755576649368,0.0245681914907371,FALSE +"HCC15","Pearson.est","sterol demethylase inhibitor",-0.56842,-1.48,0.0914,1219,0.93,"ketoconazole, lanoconazole, terconazole",1.03905380426617,0.0315170514460649,FALSE +"HCC15","Pearson.est","TGF beta receptor inhibitor",0.796,1.99,0.00323,111,0.0787,"SB.525334, LY2109761, repsox, D.4476",2.4907974776689,1.10402526764094,TRUE +"HCC15","Pearson.est","thymidylate synthase inhibitor",-0.32481,-0.844,0.636,1432,0.872,"doxifluridine",0.196542884351586,0.0594835150674328,FALSE +"HCC15","Pearson.est","topoisomerase inhibitor",-0.47308,-1.23,0.222,1177,0.791,"amonafide, exatecan.mesylate, epirubicin, etoposide, idarubicin, nemorubicin, TAS.103, amsacrine, mitoxantrone, licochalcone.a",0.653647025549361,0.101823516502323,FALSE +"HCC15","Pearson.est","tubulin polymerization inhibitor",0.55843,1.39,0.129,323,0.785,"vinblastine, vinorelbine, albendazole, fosbretabulin, vindesine, verubulin, plinabulin, taltobulin, BNC105, vincristine, indibulin, flubendazole, podophyllotoxin, docetaxel",0.889410289700751,0.105130343254747,FALSE +"HCC15","Pearson.est","tyrosine kinase inhibitor",0.32619,0.81,0.673,35,0.841,"sorafenib, tivantinib, UNC2250",0.171984935776023,0.0752040042020878,FALSE +"HCC15","Pearson.est","VEGFR inhibitor",0.39319,0.992,0.442,523,0.744,"sorafenib, OSI.930, lucitanib, telatinib, nintedanib, cediranib, RAF265, ENMD.2076, tivozanib, BMS.690514, sunitinib, KI.8751, linifanib, lenvatinib, SU014813, semaxanib, MGCD.265",0.354577730650908,0.128427064454121,FALSE +"HCC15","Pearson.est","vitamin D receptor agonist",-0.39773,-1.01,0.418,1052,0.863,"tacalcitol, maxacalcitol, paricalcitol, doxercalciferol",0.378823718224965,0.0639892042847904,FALSE diff --git a/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_venn_diagram.pdf b/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_venn_diagram.pdf new file mode 100644 index 0000000000000000000000000000000000000000..bba2ac56cae44a5ae37d02140eb05214115f9922 GIT binary 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Redistributions of source code must retain the above copyright notice, this -list of conditions and the following disclaimer. - -2. Redistributions in binary form must reproduce the above copyright notice, -this list of conditions and the following disclaimer in the documentation -and/or other materials provided with the distribution. - -THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND -ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED -WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE -DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE LIABLE -FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL -DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR -SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER -CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, -OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE -OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. \ No newline at end of file +MIT License + +Copyright (c) 2023 Belinda B. Garana + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in all +copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE +AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, +OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE +SOFTWARE. diff --git a/R/.DS_Store b/R/.DS_Store new file mode 100644 index 0000000000000000000000000000000000000000..42c16acf100ec97a5101617cf7c003b58382e732 GIT binary patch literal 6148 zcmeHK%}T>S5dJ0>8u4I{9`ghR-ykh1;=zl30JT*_h^C<4bN5vQpU;ziv$K@6$zG+% zOql(4Co}u=?UKm?koo)lIWPf`Qx&sg76YR1ReO>}%a|ykk0;c4zzv>J^}OA1hz#i7 zonnoKd$vJ$|E{pW3{zZR*3EiVH!FJTF_}@PKS5X+AvFFcKJskvm2J^u~v7?Ya2uKcsJ@*J;xlJkMCwd>EOi!UBMLWveC@rof9PJ0pk z%80F@g+t=yL*mF1ZzvK*Xa7ZThm?k1Is?wYE(1r_oM`@Er0@T`LEdr(oPmGEfQ+hT zHRqCIZtX2jb8SJrrK+f3Yq$+zC8T2dYAQaX2BE#s3bBmX8qz}XAAvxF7tX++GVlv| Ch-th4 literal 0 HcmV?d00001 diff --git a/R/DMAI.R b/R/DMAI.R deleted file mode 100755 index 5ea0c4a..0000000 --- a/R/DMAI.R +++ /dev/null @@ -1,135 +0,0 @@ -DMAI <- function(drug.sensitivity, gmt = NULL, expression, weights, - value = "AUC", sample.names = colnames(expression)[1], - gene.names = colnames(weights)[1], - weight.values = colnames(weights)[2], - rank.metric = "Pearson.est", FDR = 0.25, - num.permutations = 1000, stat.type = "Weighted", - drug.info = NULL, drug = "Drug", set.type = "moa", - min.per.set = 6, sep = "[|]", - exclusions = c("-666", "NA", "na", "NaN", "NULL"), - descriptions = NULL, min.per.corr = 3, scatter.plots = TRUE, - scatter.plot.type = "pearson", FDR.scatter.plots = 0.05, - xlab = "Weighted Voting Score", ylab = value, - position.x = "min", position.y = "min", se = TRUE, ties = FALSE) { - # check classes of expression and weight data frames are as expected - testthat::expect_is(expression, "data.frame") - testthat::expect_is(weights, "data.frame") - - # Weighted Voting (WV) - WV.result <- panSEA::WV( - expression = expression, weights = weights, - sample.names = sample.names, gene.names = gene.names, - weight.values = weight.values - ) - - used.weights <- weights[!(weights[,gene.names] %in% WV.result$unused.weights[,gene.names]),] - # Find out how many cores are available - if (requireNamespace("parallel") & - requireNamespace("snow") & - requireNamespace("doSNOW")) { - cores <- parallel::detectCores() - if (cores[1] > 1) { - cl <- snow::makeCluster(cores[1] - 1) # cluster using all but 1 core - doSNOW::registerDoSNOW(cl) # register cluster - } - } - - ### optional: weight permutations (for biomarker selection) - if (marker.select) { - WVMarkerArray <- matrix(data = NA, nrow = nperm, - ncol = length(Drug.Sets.All)) - num.Drug.Sets.all <- length(Drug.Sets.All) - `%dopar%` <- foreach::`%dopar%` - - WVMarkerArray <- foreach::foreach(L = seq_len(nrow(used.weights)), - .combine = "rbind") %dopar% { - temp.KSMarkerArray <- matrix(data = NA, nrow = 1, - ncol = num.Drug.Sets.all) - for (i in seq_len(length(Drug.Sets.All))) { - pos_gene_set <- which(temp.input[, Drug.Sets.All[i]] %in% c("X")) - - # calculate enrichment score for each drug set and rank list which excluded each gene - temp.KSMarkerArray[, i] <- GSEA.EnrichmentScore(marker.perms[,L], - pos_gene_set, - weighted.score.type = score.weight, - correl.vector = rank_metric - )$ES - } - temp.KSMarkerArray - } - colnames(KSMarkerArray) <- Drug.Sets.All - KSMarkerArray <- as.data.frame(KSMarkerArray) - - markerDiff <- KSMarkerArray - GSEA.Results$ES # check this will subtract first ES from first column values - } - - if (requireNamespace("parallel") & - requireNamespace("snow") & - requireNamespace("doSNOW")) { - if (cores[1] > 1) { - snow::stopCluster(cl) # stop cluster - rm(cl) - } - } - - # check classes of drug sensitivity data and WV output are as expected - testthat::expect_is(drug.sensitivity, "data.frame") - testthat::expect_is(WV.result$scores, "data.frame") - - # merge drug sensitivity dataframe with WV - WV.result.drug.sensitivity <- merge(WV.result$scores, drug.sensitivity, - by = sample.names - ) - - # rank_corr - corr.results <- rank_corr( - data = WV.result.drug.sensitivity, variable = drug, value = value, - type = scatter.plot.type, min.per.corr = min.per.corr, - plots = scatter.plots, FDR = FDR.scatter.plots, xlab = xlab, ylab = ylab, - position.x = position.x, position.y = position.y, se = se - ) - - # check class of rank_corr output is as expected - testthat::expect_is(corr.results$result, "data.frame") - - # if necessary, generate gmt object - if (is.null(gmt)) { - if (is.null(drug.info)) { - stop(paste( - "drug.info dataframe containing set membership information", - "must be provided as input if no gmt object is provided" - )) - } else { - corr.output <- merge(corr.results$result, drug.info, by = drug) - gmt <- as_gmt( - data = corr.output, element.names = drug, set.names = set.type, - min.per.set, sep, exclusions, descriptions - ) - } - } else { - corr.output <- corr.results$result - } - - # Drug Mechanism Enrichment Analysis (DMEA) - DMEA.results <- panSEA::drugSEA_ties( - data = corr.output, gmt = gmt, drug = drug, rank.metric = rank.metric, - set.type = set.type, direction.adjust = NULL, FDR = FDR, - num.permutations = num.permutations, stat.type = stat.type, - min.per.set = min.per.set, sep = sep, exclusions = exclusions, - descriptions = descriptions, convert.synonyms = FALSE, ties = ties - ) - - return(list( - WV.scores = WV.result$scores, - unused.weights = WV.result$unused.weights, - corr.result = corr.results$result, - corr.scatter.plots = corr.results$scatter.plots, - gmt = gmt, - result = DMEA.results$result, - result.w.ties = DMEA.results$result.w.ties, - mtn.plots = DMEA.results$mtn.plots, - volcano.plot = DMEA.results$volcano.plot, - removed.sets = DMEA.results$removed.sets, - unannotated.drugs = DMEA.results$unannotated.drugs - )) -} diff --git a/R/DMEA.R b/R/DMEA.R deleted file mode 100755 index d68775e..0000000 --- a/R/DMEA.R +++ /dev/null @@ -1,85 +0,0 @@ -DMEA <- function(drug.sensitivity, gmt = NULL, expression, weights, - value = "AUC", sample.names = colnames(expression)[1], - gene.names = colnames(weights)[1], - weight.values = colnames(weights)[2], - rank.metric = "Pearson.est", FDR = 0.25, - num.permutations = 1000, stat.type = "Weighted", - drug.info = NULL, drug = "Drug", set.type = "moa", - min.per.set = 6, sep = "[|]", - exclusions = c("-666", "NA", "na", "NaN", "NULL"), - descriptions = NULL, min.per.corr = 3, scatter.plots = TRUE, - scatter.plot.type = "pearson", FDR.scatter.plots = 0.05, - xlab = "Weighted Voting Score", ylab = value, - position.x = "min", position.y = "min", se = TRUE, ties = FALSE) { - # check classes of expression and weight data frames are as expected - testthat::expect_is(expression, "data.frame") - testthat::expect_is(weights, "data.frame") - - # Weighted Voting (WV) - WV.result <- panSEA::WV( - expression = expression, weights = weights, - sample.names = sample.names, gene.names = gene.names, - weight.values = weight.values - ) - - # check classes of drug sensitivity data and WV output are as expected - testthat::expect_is(drug.sensitivity, "data.frame") - testthat::expect_is(WV.result$scores, "data.frame") - - # merge drug sensitivity dataframe with WV - WV.result.drug.sensitivity <- merge(WV.result$scores, drug.sensitivity, - by = sample.names - ) - - # rank_corr - corr.results <- rank_corr( - data = WV.result.drug.sensitivity, variable = drug, value = value, - type = scatter.plot.type, min.per.corr = min.per.corr, - plots = scatter.plots, FDR = FDR.scatter.plots, xlab = xlab, ylab = ylab, - position.x = position.x, position.y = position.y, se = se - ) - - # check class of rank_corr output is as expected - testthat::expect_is(corr.results$result, "data.frame") - - # if necessary, generate gmt object - if (is.null(gmt)) { - if (is.null(drug.info)) { - stop(paste( - "drug.info dataframe containing set membership information", - "must be provided as input if no gmt object is provided" - )) - } else { - corr.output <- merge(corr.results$result, drug.info, by = drug) - gmt <- as_gmt( - data = corr.output, element.names = drug, set.names = set.type, - min.per.set, sep, exclusions, descriptions - ) - } - } else { - corr.output <- corr.results$result - } - - # Drug Mechanism Enrichment Analysis (DMEA) - DMEA.results <- panSEA::drugSEA_ties( - data = corr.output, gmt = gmt, drug = drug, rank.metric = rank.metric, - set.type = set.type, direction.adjust = NULL, FDR = FDR, - num.permutations = num.permutations, stat.type = stat.type, - min.per.set = min.per.set, sep = sep, exclusions = exclusions, - descriptions = descriptions, convert.synonyms = FALSE, ties = ties - ) - - return(list( - WV.scores = WV.result$scores, - unused.weights = WV.result$unused.weights, - corr.result = corr.results$result, - corr.scatter.plots = corr.results$scatter.plots, - gmt = gmt, - result = DMEA.results$result, - result.w.ties = DMEA.results$result.w.ties, - mtn.plots = DMEA.results$mtn.plots, - volcano.plot = DMEA.results$volcano.plot, - removed.sets = DMEA.results$removed.sets, - unannotated.drugs = DMEA.results$unannotated.drugs - )) -} diff --git a/R/DMEA_cell_corr.R b/R/DMEA_cell_corr.R old mode 100755 new mode 100644 index f125c3f..02ac774 --- a/R/DMEA_cell_corr.R +++ b/R/DMEA_cell_corr.R @@ -13,7 +13,7 @@ DMEA_cell_corr <- function(drug.sensitivity, gmt = NULL, expression, weights, FDR.scatter.plots = 0.05, xlab = "Expression Correlation Estimate", ylab = value, - position.x = "min", position.y = "min", se = TRUE, ties = FALSE) { + position.x = "min", position.y = "min", se = TRUE) { # reformat expression data frame with cell lines as column names rownames(expression) <- expression[ , sample.names] expr <- as.data.frame(t(expression)) @@ -44,11 +44,11 @@ DMEA_cell_corr <- function(drug.sensitivity, gmt = NULL, expression, weights, se = se) # run drugSEA - DMEA.results <- panSEA::drugSEA_ties( + DMEA.results <- DMEA::drugSEA( drug.corr$result, gmt, drug, rank.metric, set.type, FDR = FDR, num.permutations = num.permutations, stat.type = stat.type, min.per.set = min.per.set, sep = sep, exclusions = exclusions, - descriptions = descriptions, ties = ties + descriptions = descriptions ) return(list( diff --git a/R/DMEA_gene_corr.R b/R/DMEA_gene_corr.R old mode 100755 new mode 100644 index 737fff7..bfecd85 --- a/R/DMEA_gene_corr.R +++ b/R/DMEA_gene_corr.R @@ -1,5 +1,5 @@ -DMEA_gene_corr <- function(gmt = NULL, expression, weights, - value = "Perturbation", sample.names = "Drug", +DMEA_gene_corr <- function(drug.sensitivity, gmt = NULL, expression, weights, + value = "AUC", sample.names = colnames(expression)[1], gene.names = colnames(weights)[1], weight.values = colnames(weights)[2], rank.metric = "Pearson.est", FDR = 0.25, @@ -13,39 +13,29 @@ DMEA_gene_corr <- function(gmt = NULL, expression, weights, FDR.scatter.plots = 0.05, xlab = "Expression Correlation Estimate", ylab = value, - position.x = "min", position.y = "min", se = TRUE, ties = FALSE) { + position.x = "min", position.y = "min", se = TRUE) { # merge expression data frame with input weights expr.weights <- merge(weights[ , c(gene.names, weight.values)], expression, by = gene.names) - if (nrow(na.omit(expr.weights)) > 2) { - # for each drug line: run correlation between expression & input weights - # data points are genes - drug.corr <- DMEA::rank_corr(expr.weights, variable = sample.names, - value = value, type = scatter.plot.type, - min.per.corr = min.per.corr, - plots = scatter.plots, - FDR = FDR.scatter.plots, - xlab = xlab, ylab = ylab, - position.x = position.x, - position.y = position.y, se = se) - - # run drugSEA - DMEA.results <- panSEA::drugSEA_ties( - drug.corr$result, gmt, drug, rank.metric, set.type, FDR = FDR, - num.permutations = num.permutations, stat.type = stat.type, - min.per.set = min.per.set, sep = sep, exclusions = exclusions, - descriptions = descriptions, ties = ties - ) - } else { - drug.corr <- list("result" = data.frame(), - "scatter.plots" = NA) - DMEA.results <- list("result" = data.frame(), - "mtn.plots" = list(), - "volcano.plot" = list(), - "removed.sets" = data.frame(), - "unannotated.drugs" = data.frame()) - } + # for each drug line: run correlation between expression & input weights + # data points are genes + drug.corr <- DMEA::rank_corr(expr.weights, variable = sample.names, + value = value, type = scatter.plot.type, + min.per.corr = min.per.corr, + plots = scatter.plots, + FDR = FDR.scatter.plots, + xlab = xlab, ylab = ylab, + position.x = position.x, + position.y = position.y, se = se) + + # run drugSEA + DMEA.results <- DMEA::drugSEA( + drug.corr$result, gmt, drug, rank.metric, set.type, FDR = FDR, + num.permutations = num.permutations, stat.type = stat.type, + min.per.set = min.per.set, sep = sep, exclusions = exclusions, + descriptions = descriptions + ) return(list( corr.result = drug.corr$result, diff --git a/R/WV.R b/R/WV.R deleted file mode 100755 index ccfd870..0000000 --- a/R/WV.R +++ /dev/null @@ -1,62 +0,0 @@ -WV <- function(expression, weights, sample.names = colnames(expression)[1], - gene.names = colnames(weights)[1], - weight.values = colnames(weights)[2]) { - # expression: cell lines should be rows, genes should be columns - # weights: one column should contain gene symbols, - # another column should be gene weights - message("Calculating Weighted Voting scores...") - - # check classes of inputs are as expected - testthat::expect_is(expression, "data.frame") - testthat::expect_is(weights, "data.frame") - - # remove gene names not found in expression - unused.weights <- weights[!(weights[, gene.names] %in% - colnames(expression)[2:ncol(expression)]), ] - filtered.weights <- weights[weights[, gene.names] %in% - colnames(expression)[2:ncol(expression)], - c(gene.names, weight.values)] - filtered.weights <- na.omit(filtered.weights) - - # check expression for gene names - filtered.expr <- expression %>% - dplyr::select(c(tidyselect::all_of(sample.names), - tidyselect::all_of(filtered.weights[, gene.names]))) - filtered.expr <- filtered.expr[,colSums(is.na(filtered.expr)) == 0] - filtered.weights <- filtered.weights[filtered.weights[,gene.names] %in% - colnames(filtered.expr)[2:ncol(filtered.expr)],] - - if (nrow(filtered.expr) > 0) { - ## prep for matrix multiplication - # store sample names in row names - rownames(filtered.expr) <- filtered.expr[, sample.names] - - # remove sample names from expression - filtered.expr.data <- dplyr::select(filtered.expr, - -c(tidyselect::all_of(sample.names))) - - # remove gene names from weights - weight.data <- dplyr::select(filtered.weights, - -c(tidyselect::all_of(gene.names))) - - # format data frames as matrices - weight.matrix <- as.matrix(weight.data) - expr.matrix <- as.matrix(filtered.expr.data) - - ## perform matrix multiplication - scores <- as.data.frame(expr.matrix %*% weight.matrix) - - ## format dataframe for output - colnames(scores)[1] <- "WV" - scores[, c(sample.names)] <- rownames(scores) - scores <- scores %>% relocate(colnames(scores)[2], .before = WV) - - # check classes of outputs are as expected - testthat::expect_is(scores, "data.frame") - testthat::expect_is(unused.weights, "data.frame") - } else { - stop(paste("expression data frame does not contain", - "any of the gene symbols provided")) - } - return(list(scores = scores, unused.weights = unused.weights)) -} diff --git a/R/compile_mDEG.R b/R/compile_mDEG.R old mode 100755 new mode 100644 diff --git a/R/compile_mDMEA.R b/R/compile_mDMEA.R old mode 100755 new mode 100644 diff --git a/R/compile_mGSEA.R b/R/compile_mGSEA.R old mode 100755 new mode 100644 index d1f1951..2da043a --- a/R/compile_mGSEA.R +++ b/R/compile_mGSEA.R @@ -8,13 +8,11 @@ compile_mGSEA <- function(ssGSEA.list, p = 0.05, FDR = 0.25, n.dot.sets = 10) { } # collapse GSEA results across omics types - GSEA.df <- as.data.frame(data.table::rbindlist(GSEA.df, use.names = TRUE, idcol = "type")) + GSEA.df <- data.table::rbindlist(GSEA.df, use.names = TRUE, idcol = "type") GSEA.df$minusLogP <- -log(GSEA.df$p_value, base = 10) GSEA.df$minusLogFDR <- -log(GSEA.df$FDR_q_value, base = 10) GSEA.df$sig <- FALSE - if (nrow(GSEA.df[GSEA.df$p_value < p & GSEA.df$FDR_q_value < FDR, ]) > 0) { - GSEA.df[GSEA.df$p_value < p & GSEA.df$FDR_q_value < FDR, ]$sig <- TRUE - } + GSEA.df[GSEA.df$p_value < p & GSEA.df$FDR_q_value < FDR, ]$sig <- TRUE # summarize results for each Feature_set mean.GSEA.df <- plyr::ddply(GSEA.df, .(Feature_set), summarize, @@ -25,7 +23,7 @@ compile_mGSEA <- function(ssGSEA.list, p = 0.05, FDR = 0.25, n.dot.sets = 10) { N_types = length(unique(type)), N_sig = length(sig[sig]), sig_types = paste0(type[sig], collapse = ", ")) - if (length(na.omit(unique(mean.GSEA.df$Fisher_p))) > 1) { + if (length(unique(mean.GSEA.df$Fisher_p)) > 1) { mean.GSEA.df$adj_Fisher_p <- qvalue::qvalue(mean.GSEA.df$Fisher_p, pi0=1)$qvalues } else { @@ -47,9 +45,6 @@ compile_mGSEA <- function(ssGSEA.list, p = 0.05, FDR = 0.25, n.dot.sets = 10) { mean.GSEA.df %>% dplyr::slice_max(abs(mean_NES), n = n.dot.sets) } dot.df <- GSEA.df[GSEA.df$Feature_set %in% top.GSEA.df$Feature_set, ] - if (any(dot.df$FDR_q_value == 0)) { - dot.df[dot.df$FDR_q_value == 0,]$FDR_q_value <- 0.0001 - } ## create venn diagram # compile significant results for each type in list diff --git a/R/drugSAI.R b/R/drugSAI.R deleted file mode 100755 index eceb17a..0000000 --- a/R/drugSAI.R +++ /dev/null @@ -1,993 +0,0 @@ - -# load GSEA_custom function -GSEA_custom <- function(input.df, gmt.list, - nperm = 1000, - stat.type = "Weighted", min.per.set, - convert.synonyms = FALSE, ties = FALSE, marker.select=TRUE) { - GSEA.EnrichmentScore <- function(gene.list, gene.set, - weighted.score.type = score.weight, - correl.vector = NULL) { - tag.indicators <- sign(match(gene.list, gene.set, nomatch = 0)) - no.tag.indicator <- 1 - tag.indicators - N <- length(gene.list) - Nh <- sum(tag.indicators) - Nm <- N - Nh - if (weighted.score.type == 0) { - correl.vector <- rep(1, N) - } - alpha <- weighted.score.type - correl.vector <- abs(correl.vector**alpha) - sum.correl.tag <- sum(correl.vector[tag.indicators == 1]) - norm.tag <- 1.0 / sum.correl.tag - norm.no.tag <- 1.0 / Nm - RES <- - cumsum(tag.indicators * correl.vector * norm.tag - - no.tag.indicator * norm.no.tag) - max.ES <- max(RES) - min.ES <- min(RES) - if (max.ES > -min.ES) { - ES <- signif(max.ES, digits = 5) - arg.ES <- which.max(RES) - } else { - ES <- signif(min.ES, digits = 5) - arg.ES <- which.min(RES) - } - return(list( - ES = ES, - arg.ES = arg.ES, - RES = RES, - indicator = tag.indicators - )) - } - - # set weight for drug ranks - if (stat.type == "Classic") { - score.weight <- 0 - } else if (stat.type == "Weighted") { - score.weight <- 1 - } - - # find biggest drug set - biggest.set <- min.per.set - for (i in seq_len(length(gmt.list$genesets))) { - if (length(gmt.list$genesets[[i]]) > biggest.set) { - biggest.set <- length(gmt.list$genesets[[i]]) - } - } - - # restructure drug sets so that each MOA is a column with drugs in rows - # also generate list of all annotated drugs from gmt - Drug.Sets <- matrix( - data = "", nrow = biggest.set, - ncol = length(gmt.list$genesets) - ) - colnames(Drug.Sets) <- gmt.list$geneset.names - annotated.drugs <- c() - for (i in seq_len(ncol(Drug.Sets))) { - for (j in seq_len(length(gmt.list$genesets[[i]]))) { - Drug.Sets[j, i] <- gmt.list$genesets[[i]][[j]][1] - annotated.drugs <- c(annotated.drugs, gmt.list$genesets[[i]][[j]][1]) - } - } - Drug.Sets <- as.data.frame(Drug.Sets) - annotated.drugs <- unique(annotated.drugs) - - # check class of inputs is as expected - testthat::expect_is(input.df, "data.frame") - testthat::expect_is(Drug.Sets, "data.frame") - - Samples <- colnames(input.df)[2] - Drug.Sets.All <- colnames(Drug.Sets) - - annotations <- matrix( - data = 0, nrow = nrow(input.df), - ncol = length(Drug.Sets.All) - ) - colnames(annotations) <- Drug.Sets.All - - annotations <- as.data.frame(annotations) - - annotations <- cbind(input.df[, 1], annotations) - colnames(annotations) <- c(colnames(input.df)[1], Drug.Sets.All) - annotations <- as.matrix(annotations) - - # Find out how many cores are available - if (requireNamespace("parallel") & - requireNamespace("snow") & - requireNamespace("doSNOW")) { - cores <- parallel::detectCores() - if (cores[1] > 1) { - cl <- snow::makeCluster(cores[1] - 1) # cluster using all but 1 core - doSNOW::registerDoSNOW(cl) # register cluster - } - } - - num.hits.pathways <- as.data.frame(Drug.Sets.All) - num.hits.pathways$N_drugs <- NA - ### Annotate drug sets - for (j in seq_len(length(Drug.Sets.All))) { - temp.pathway <- Drug.Sets[, Drug.Sets.All[j]] - for (i in seq_len(nrow(annotations))) { - if (annotations[i, 1] %in% temp.pathway) { - annotations[i, j + 1] <- "X" - } - } - num.hits.pathways$N_drugs[j] <- - sum(annotations[, Drug.Sets.All[j]] == "X") - } - - ### Check if any drugs are not in any sets - unannotated.drugs <- c() - for (i in seq_len(nrow(annotations))) { - if (sum(annotations[i, 2:ncol(annotations)] == "X") == 0) { - unannotated.drugs <- c(unannotated.drugs, annotations[i, 1]) - } - } - - ### Check if these unannotated drug names are a synonym for an annotated drug - if (convert.synonyms) { - # access drug synonyms - synonyms <- utils::read.csv( - paste0("https://raw.github.com/BelindaBGarana/DMEA/", - "shiny-app/Inputs/PRISM_drug_synonyms.csv") - ) - replacements <- as.data.frame(unannotated.drugs) - replacements[, c("PRISM_drug_name", - "PubChem_CID", "PubChem_synonyms")] <- NA - for (i in seq_len(length(unannotated.drugs))) { - # check if unannotated drug name is a CID for a PRISM drug - if (unannotated.drugs[i] %in% synonyms$PubChem_CID) { - replacements[i, c("PRISM_drug_name", - "PubChem_CID", "PubChem_synonyms")] <- - synonyms[synonyms$PubChem_CID == unannotated.drugs[i], ] - } else { - # else check if unannotated drug is a synonym for a PRISM drug name - for (j in seq_len(nrow(synonyms))) { - temp.synonyms <- strsplit(synonyms$PubChem_synonyms[j], "[|]") - if (unannotated.drugs[i] %in% temp.synonyms) { - replacements[i, c("PRISM_drug_name", - "PubChem_CID", "PubChem_synonyms")] <- - synonyms[j, c("PRISM_drug_name", - "PubChem_CID", "PubChem_synonyms")] - break - } - } - } - } - unannotated.drugs <- - replacements[is.na(replacements$PRISM_drug_name), ]$unannotated.drugs - - # remove any drugs which were not replaced - replacements <- na.omit(replacements) - rm(synonyms) - - # replace drug names in rank list - for (i in seq_len(nrow(input.df))) { - if (input.df[i, 1] %in% replacements$unannotated.drugs) { - input.df[i, 1] <- - replacements[replacements$unannotated.drugs == input.df[i, 1], - ]$PRISM_drug_name - } - } - - # redo annotations - annotations <- matrix( - data = 0, nrow = nrow(input.df), - ncol = length(Drug.Sets.All) - ) - colnames(annotations) <- Drug.Sets.All - - annotations <- as.data.frame(annotations) - - annotations <- cbind(input.df[, 1], annotations) - colnames(annotations) <- c(colnames(input.df)[1], Drug.Sets.All) - annotations <- as.matrix(annotations) - - ### Annotate drug sets - for (j in seq_len(length(Drug.Sets.All))) { - temp.pathway <- Drug.Sets[, Drug.Sets.All[j]] - for (i in seq_len(nrow(annotations))) { - if (annotations[i, 1] %in% temp.pathway) { - annotations[i, j + 1] <- "X" - } - } - num.hits.pathways$N_drugs[j] <- - sum(annotations[, Drug.Sets.All[j]] == "X") - } - } else { - replacements <- NULL - } - unannotated.input <- input.df[input.df[, 1] %in% unannotated.drugs, ] - - Drug.Sets.under <- - num.hits.pathways[num.hits.pathways$N_drugs < min.per.set, ]$Drug.Sets.All - Drug.Sets.over <- - num.hits.pathways[num.hits.pathways$N_drugs >= min.per.set, - ]$Drug.Sets.All - if (length(Drug.Sets.under) > 0) { - warning(paste0( - "Removing drug sets with less than ", min.per.set, - " drugs observed in data set" - )) - annotations <- annotations[, c(colnames(input.df)[1], Drug.Sets.All)] - - # only keep drug sets with >= min.per.set drugs - Drug.Sets.All <- Drug.Sets.over - } - colnames(num.hits.pathways)[1] <- "Drug_set" - if (length(Drug.Sets.over) < 2) { - stop("annotations for 2+ sets are required") - } # BG 2022-06-25 - annotations <- as.data.frame(annotations) - input.df <- merge(input.df, annotations, by = colnames(input.df)[1]) - input.df <- stats::na.omit(input.df) - rm(annotations) - - GSEA.Results <- matrix(data = NA, nrow = length(Drug.Sets.All), ncol = 8) - colnames(GSEA.Results) <- c( - "Rank_metric", "Drug_set", "ES", "NES", - "p_value", "Position_at_max", "FDR_q_value", "Leading_edge" - ) - GSEA.Results <- as.data.frame(GSEA.Results) - GSEA.Results$Drug_set <- Drug.Sets.All - GSEA.Results$Rank_metric <- Samples - - ## Assuming first two columns in data table are drug names and - ## rank metric (e.g. Foldchange, SNR) - input.df[, Samples] <- as.numeric(as.character(input.df[, Samples])) - - # sort by descending order for the rank metric - input.df <- input.df[order(-input.df[, Samples]), ] - - # reorder row indices for counting in for loop below - rownames(input.df) <- seq_len(nrow(input.df)) - ions <- nrow(input.df) - - # for plotting - ks_results_plot <- list() - positions.of.hits <- list() - - gene.list <- seq_len(ions) - rank_metric <- input.df[, Samples] # Save the rank metric - - pos_gene_set <- array(data = 0, dim = nrow(input.df), dimnames = NULL) - - ## Calculate Real KS Statistic with original input - message("calculating ES with original input") - for (i in seq_len(length(Drug.Sets.All))) { - pos_gene_set <- which(input.df[, Drug.Sets.All[i]] %in% c("X")) - KS_real <- GSEA.EnrichmentScore(gene.list, pos_gene_set, - weighted.score.type = score.weight, - correl.vector = rank_metric - ) - - # store ES and positions - GSEA.Results[GSEA.Results$Drug_set == Drug.Sets.All[i], - ]$ES <- KS_real$ES - GSEA.Results[GSEA.Results$Drug_set == Drug.Sets.All[i], - ]$Position_at_max <- KS_real$arg.ES - ks_results_plot[[Drug.Sets.All[i]]] <- KS_real$RES - positions.of.hits[[Drug.Sets.All[i]]] <- pos_gene_set - - # identify leading edge elements - if (KS_real$ES <= 0) { - pos_leading_edge <- pos_gene_set[pos_gene_set >= KS_real$arg.ES] - } else if (KS_real$ES >= 0) { - pos_leading_edge <- pos_gene_set[pos_gene_set <= KS_real$arg.ES] - } - leading_edge <- input.df[pos_leading_edge, 1] - GSEA.Results[GSEA.Results$Drug_set == Drug.Sets.All[i], - ]$Leading_edge <- paste(leading_edge, collapse = ", ") - } - Mountain.Plot.Info <- list( - MountainPlot = ks_results_plot, - Position.of.hits = positions.of.hits - ) - rm(pos_gene_set) - rm(KS_real) - - ### tie permutations (NOT a null distribution) - if (ties) { - KSRandomArray_ties <- matrix(data = NA, nrow = nperm, - ncol = length(Drug.Sets.All)) - num.Drug.Sets.all <- length(Drug.Sets.All) - `%dopar%` <- foreach::`%dopar%` - message("calculating ES with shuffled ties") - KSRandomArray_ties <- foreach::foreach(L = seq_len(nperm), - .combine = "rbind") %dopar% { - # randomly jitter list to shuffle ties - temp.input <- input.df[order(-input.df[, Samples], jitter(-input.df[, Samples])),] - rownames(temp.input) <- seq_len(nrow(temp.input)) # adding in case random result is due to nonsequential rownames? - gene.list <- rownames(temp.input) - - temp.KSRandomArray <- matrix(data = NA, nrow = 1, - ncol = num.Drug.Sets.all) - for (i in seq_len(length(Drug.Sets.All))) { - pos_gene_set <- which(temp.input[, Drug.Sets.All[i]] %in% c("X")) - - # calculate ES with shuffled ties - temp.KSRandomArray[, i] <- GSEA.EnrichmentScore(gene.list, - pos_gene_set, - weighted.score.type = score.weight, - correl.vector = temp.input[, Samples] - )$ES - } - temp.KSRandomArray - } - colnames(KSRandomArray_ties) <- Drug.Sets.All - KSRandomArray_ties <- as.data.frame(KSRandomArray_ties) - - ### calculate ES & NES - # let ES = mean of ES tie distribution and NES = mean of NES tie distribution - GSEA.Results.ties <- matrix(data = NA, nrow = length(Drug.Sets.All), ncol = 11) - colnames(GSEA.Results.ties) <- c( - "Rank_metric", "Drug_set", "ES","ES_min","ES_max", "ES_sd", - "NES", "NES_min", "NES_max", "p_value", "FDR_q_value" - ) - GSEA.Results.ties <- as.data.frame(GSEA.Results.ties) - GSEA.Results.ties$Drug_set <- Drug.Sets.All - GSEA.Results.ties$Rank_metric <- Samples - GSEA.Results.ties$ES <- colMeans(KSRandomArray_ties, na.rm = TRUE) - GSEA.Results.ties$ES_min <- apply(KSRandomArray_ties, 2, min) - GSEA.Results.ties$ES_max <- apply(KSRandomArray_ties, 2, max) - GSEA.Results.ties$ES_sd <- apply(KSRandomArray_ties, 2, sd) - percent.pos.GSEA.ties <- sum(GSEA.Results.ties$ES >= 0) / - length(GSEA.Results.ties$ES) # BG OR EQUAL TO - percent.neg.GSEA.ties <- sum(GSEA.Results.ties$ES <= 0) / - length(GSEA.Results.ties$ES) # BG OR EQUAL TO - } - - ### optional: weight permutations (for biomarker selection) - if (marker.select) { - KSMarkerArray <- matrix(data = NA, nrow = nperm, - ncol = length(Drug.Sets.All)) - num.Drug.Sets.all <- length(Drug.Sets.All) - `%dopar%` <- foreach::`%dopar%` - - KSMarkerArray <- foreach::foreach(L = seq_len(ncol(marker.perms)), - .combine = "rbind") %dopar% { - temp.KSMarkerArray <- matrix(data = NA, nrow = 1, - ncol = num.Drug.Sets.all) - for (i in seq_len(length(Drug.Sets.All))) { - pos_gene_set <- which(temp.input[, Drug.Sets.All[i]] %in% c("X")) - - # calculate enrichment score for each drug set and rank list which excluded each gene - temp.KSMarkerArray[, i] <- GSEA.EnrichmentScore(marker.perms[,L], - pos_gene_set, - weighted.score.type = score.weight, - correl.vector = rank_metric - )$ES - } - temp.KSMarkerArray - } - colnames(KSMarkerArray) <- Drug.Sets.All - KSMarkerArray <- as.data.frame(KSMarkerArray) - - markerDiff <- KSMarkerArray - GSEA.Results$ES # check this will subtract first ES from first column values - } else{ #SG Added to avoid error - markerDiff <- rep(0,nrow(GSEA.Results)) - } - - ### MOA permutations (null distribution) - KSRandomArray <- matrix(data = NA, nrow = nperm, - ncol = length(Drug.Sets.All)) - num.Drug.Sets.all <- length(Drug.Sets.All) - `%dopar%` <- foreach::`%dopar%` - - KSRandomArray <- foreach::foreach(L = seq_len(nperm), - .combine = "rbind") %dopar% { - temp.KSRandomArray <- matrix(data = NA, nrow = 1, - ncol = num.Drug.Sets.all) - for (i in seq_len(length(Drug.Sets.All))) { - # randomly sample drug set of same size as original set - numhits_pathway <- length(positions.of.hits[[Drug.Sets.All[i]]]) - pos_gene_set <- sample(seq_len(ions), numhits_pathway) - - # calculate null enrichment score - temp.KSRandomArray[, i] <- GSEA.EnrichmentScore(gene.list, - pos_gene_set, - weighted.score.type = score.weight, - correl.vector = rank_metric - )$ES - } - temp.KSRandomArray - } - colnames(KSRandomArray) <- Drug.Sets.All - KSRandomArray <- as.data.frame(KSRandomArray) - - ### normalize the GSEA distribution - KSRandomArray.Norm <- matrix( - data = NA, nrow = nrow(KSRandomArray), - ncol = ncol(KSRandomArray) - ) - colnames(KSRandomArray.Norm) <- colnames(KSRandomArray) - KSRandomArray.temp <- 0 - for (i in seq_len(ncol(KSRandomArray.Norm))) { - KSRandomArray.temp <- KSRandomArray[, i] - pos.temp <- KSRandomArray.temp[which(KSRandomArray.temp >= 0)] - neg.temp <- - KSRandomArray.temp[which(KSRandomArray.temp <= 0)] # BG OR EQUAL TO - - avg.pos <- mean(pos.temp) - avg.neg <- mean(neg.temp) - - norm.pos.temp <- pos.temp / avg.pos - norm.neg.temp <- neg.temp / avg.neg * -1 - - norm.perms <- c(norm.pos.temp, norm.neg.temp) - - KSRandomArray.Norm[, i] <- norm.perms - } - GSEA.NES.perms <- as.vector(KSRandomArray.Norm) - rm(KSRandomArray.Norm) - GSEA.NES.perms.pos <- GSEA.NES.perms[which(GSEA.NES.perms >= 0)] - GSEA.NES.perms.neg <- - GSEA.NES.perms[which(GSEA.NES.perms <= 0)] # BG OR EQUAL TO - rm(GSEA.NES.perms) - percent.pos.GSEA <- sum(GSEA.Results$ES >= 0) / - length(GSEA.Results$ES) # BG OR EQUAL TO - percent.neg.GSEA <- sum(GSEA.Results$ES <= 0) / - length(GSEA.Results$ES) # BG OR EQUAL TO - - # Calculate GSEA NES and p-value - for (i in seq_len(length(Drug.Sets.All))) { - temp.gene.set <- Drug.Sets.All[i] - temp.perms <- KSRandomArray[, temp.gene.set] - temp.ES <- GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$ES - if (ties) { - temp.ES.tie <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$ES - temp.ES.tie.min <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$ES_min - temp.ES.tie.max <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$ES_max - } - pos.perms <- temp.perms[which(temp.perms >= 0)] # BG OR EQUAL TO - neg.perms <- temp.perms[which(temp.perms <= 0)] # BG OR EQUAL TO - - # original input order - if (temp.ES >= 0) { # BG OR EQUAL TO - # p-value - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$p_value <- - signif(sum(pos.perms >= temp.ES) / - length(pos.perms), digits = 3) # BG OR EQUAL TO - - # NES - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES <- - signif(temp.ES / mean(pos.perms), digits = 3) - } else { # BG OR EQUAL TO - # p-value - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$p_value <- - signif(sum(neg.perms <= temp.ES) / - length(neg.perms), digits = 3) # BG OR EQUAL TO - - # NES - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES <- - signif(temp.ES / mean(neg.perms) * -1, digits = 3) - } - - # shuffled ties - if (ties) { - if (temp.ES.tie >= 0) { - # p-value - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$p_value <- - signif(sum(pos.perms >= temp.ES.tie.min) / - length(pos.perms), digits = 3) - - # NES - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES <- - signif(temp.ES.tie / mean(pos.perms), digits = 3) - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_min <- - signif(temp.ES.tie.min / mean(pos.perms), digits = 3) - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_max <- - signif(temp.ES.tie.max / mean(pos.perms), digits = 3) - } else { # BG OR EQUAL TO - # p-val - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$p_value <- - signif(sum(neg.perms <= temp.ES) / - length(neg.perms), digits = 3) # BG OR EQUAL TO - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$p_value <- - signif(sum(neg.perms <= temp.ES.tie.max) / - length(neg.perms), digits = 3) - - # NES - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES <- - signif(temp.ES.tie / mean(neg.perms) * -1, digits = 3) - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_min <- - signif(temp.ES.tie.min / mean(neg.perms) * -1, digits = 3) - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_max <- - signif(temp.ES.tie.max / mean(neg.perms) * -1, digits = 3) - } - } - } - - # Calculate GSEA FDR - for (i in seq_len(length(Drug.Sets.All))) { - temp.gene.set <- Drug.Sets.All[i] - temp.NES <- GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES - if (ties) { - temp.NES.tie <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES - temp.NES.tie.min <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_min - temp.NES.tie.max <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_max - } - - # results for original input - if (temp.NES >= 0) { # BG OR EQUAL TO - percent.temp <- - sum(GSEA.NES.perms.pos >= - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES) / - length(GSEA.NES.perms.pos) # BG OR EQUAL TO - percent.pos.stronger <- - sum(GSEA.Results$NES >= - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES) / - sum(GSEA.Results$NES >= 0) # BG - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$FDR_q_value <- - ifelse(signif(percent.temp / percent.pos.stronger, digits = 3) < 1, - signif(percent.temp / percent.pos.stronger, digits = 3), 1 - ) # BG - } else { # BG OR EQUAL TO - percent.temp <- sum(GSEA.NES.perms.neg <= temp.NES) / - length(GSEA.NES.perms.neg) # BG OR EQUAL TO - percent.neg.stronger <- sum(GSEA.Results$NES <= temp.NES) / - sum(GSEA.Results$NES <= 0) # BG - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$FDR_q_value <- - ifelse(signif(percent.temp / percent.neg.stronger, digits = 3) < 1, - signif(percent.temp / percent.neg.stronger, digits = 3), 1 - ) # BG - } - - # results for shuffled ties - if (ties) { - if (temp.NES.tie >= 0) { - percent.temp <- - sum(GSEA.NES.perms.pos >= temp.NES.tie.min) / length(GSEA.NES.perms.pos) # BG OR EQUAL TO - percent.pos.stronger <- - sum(GSEA.Results.ties$NES_max >= temp.NES.tie.min) / sum(GSEA.Results.ties$NES >= 0) # BG - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$FDR_q_value <- - ifelse(signif(percent.temp / percent.pos.stronger, digits = 3) < 1, - signif(percent.temp / percent.pos.stronger, digits = 3), 1 - ) # BG - } else { - percent.temp <- sum(GSEA.NES.perms.neg <= temp.NES.tie.max) / length(GSEA.NES.perms.neg) # BG OR EQUAL TO - percent.neg.stronger <- sum(GSEA.Results.ties$NES_min <= temp.NES.tie.max) / sum(GSEA.Results.ties$NES <= 0) # BG - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$FDR_q_value <- - ifelse(signif(percent.temp / percent.neg.stronger, digits = 3) < 1, - signif(percent.temp / percent.neg.stronger, digits = 3), 1 - ) # BG - } - } - } - - if (requireNamespace("parallel") & - requireNamespace("snow") & - requireNamespace("doSNOW")) { - if (cores[1] > 1) { - snow::stopCluster(cl) # stop cluster - rm(cl) - } - } - - if (!ties) { - GSEA.Results.ties <- data.frame() - } - - return(list( - GSEA.Results = GSEA.Results, - GSEA.Results.ties = GSEA.Results.ties, - Mountain.Plot.Info = Mountain.Plot.Info, - ranking.metric = rank_metric, - removed.sets = - num.hits.pathways[num.hits.pathways$N_drugs < min.per.set, ], - replacements = replacements, - unannotated.drugs = unannotated.input, - marker.importance = markerDiff - )) -} - -# load mountain plot function -gsea_mountain_plot <- function(GSEA.list, Sample.Name, Gene.Set.A, - color = TRUE) { - if (color) { - color.palette <- c("red") - } else if (!color) { - color.palette <- c("black") - } - - GSEA.list <- GSEA.list - plotting.info <- GSEA.list$Mountain.Plot.Info - ES_profiles <- plotting.info$MountainPlot - position.of.hits <- plotting.info$Position.of.hits - - ranking.metric <- as.numeric(GSEA.list$ranking.metric) - - ES_GeneSetA <- ES_profiles[[Gene.Set.A]] - - pos.GeneSetA <- position.of.hits[[Gene.Set.A]] - - myName <- Gene.Set.A - - GSEA.results <- GSEA.list$GSEA.Results - GSEA.results <- GSEA.results[GSEA.results$Rank_metric == Sample.Name, ] - GSEA.results$p_value <- as.numeric(as.character(GSEA.results$p_value)) - GSEA.results$FDR_q_value <- as.numeric(as.character(GSEA.results$FDR_q_value)) - - gsea.normalized.enrichment.score <- - signif(GSEA.results[GSEA.results$Drug_set == myName, ]$NES, digits = 3) - gsea.p.value <- - signif(GSEA.results[GSEA.results$Drug_set == myName, ]$p_value, - digits = 3) - gsea.q.val <- - signif(GSEA.results[GSEA.results$Drug_set == myName, ]$FDR_q_value, - digits = 3) - - results.as.text <- paste( - "NES", gsea.normalized.enrichment.score, "\np-value:", gsea.p.value, - "\nq-value:", gsea.q.val - ) - - gsea.hit.indices.A <- pos.GeneSetA - - gsea.es.profile.A <- ES_GeneSetA[gsea.hit.indices.A] - - ngenes <- length(ES_GeneSetA) - combined.ES <- c(ES_GeneSetA) - max.ES <- max(combined.ES) - min.ES <- min(combined.ES) - - mtn.plot <- NULL - mtn.plot <- ggplot2::ggplot() + - ggplot2::geom_line( - ggplot2::aes( - x = c(0, pos.GeneSetA, ngenes), - y = c(0, gsea.es.profile.A, 0) - ), - color = color.palette[1], size = 1 - ) + - ggplot2::labs(x = NULL, y = "ES", title = myName) + - ggplot2::scale_x_continuous(expand = c(0, 0)) + - ggplot2::theme_bw() + - ggplot2::geom_hline(yintercept = 0, linetype = "dashed", - color = "grey50") + - ggplot2::theme( - axis.text.x = ggplot2::element_blank(), - axis.ticks.x = ggplot2::element_blank(), - axis.ticks.length = ggplot2::unit(0, "pt"), - axis.title.x = ggplot2::element_blank(), - panel.grid = ggplot2::element_blank(), - plot.background = ggplot2::element_blank(), - plot.margin = ggplot2::unit(c(0, 0, 0, 0), "cm"), - plot.title = ggplot2::element_text(hjust = 0.5) - ) - - if (!is.null(gsea.normalized.enrichment.score) & - length(gsea.normalized.enrichment.score) > 0) { - if (gsea.normalized.enrichment.score > 0) { - mtn.plot <- mtn.plot + ggplot2::annotate("text", - label = results.as.text, x = ngenes * 0.90, - y = max.ES * 0.70, color = "black" - ) - } else if (gsea.normalized.enrichment.score < 0) { - mtn.plot <- mtn.plot + ggplot2::annotate("text", - label = results.as.text, x = ngenes * 0.10, - y = min.ES * 0.30, color = "black" - ) - } - } - - hit.markers <- ggplot2::ggplot() + - cowplot::theme_nothing() + - ggplot2::theme(panel.border = ggplot2::element_rect(color = "black", - fill = NA)) + - ggplot2::geom_col(ggplot2::aes(x = pos.GeneSetA, y = 1), - color = color.palette[1], - fill = color.palette[1], width = 0.75 - ) + - ggplot2::labs(x = NULL, y = NULL) + - ggplot2::scale_y_continuous(expand = c(0, 0)) + - aplot::xlim2(mtn.plot) - - show.rank.metric <- ggplot2::ggplot() + - ggplot2::geom_line(ggplot2::aes( - x = seq_len(ngenes), - y = ranking.metric - ), color = "grey50") + - ggplot2::geom_area(ggplot2::aes( - x = seq_len(ngenes), - y = ranking.metric - ), fill = "grey50") + - ggplot2::labs(x = "Rank", y = "Rank Metric") + - ggplot2::theme_bw() + - ggplot2::theme( - panel.grid = ggplot2::element_blank(), - plot.title = ggplot2::element_blank(), - plot.margin = ggplot2::unit(c(0, 0, 0, 0), "cm") - ) + - aplot::xlim2(mtn.plot) - - assembled <- mtn.plot + hit.markers + show.rank.metric + - patchwork::plot_layout(ncol = 1, heights = c(2.5, 0.5, 2)) - return(assembled) -} - -summaryPlots <- function(EA, FDR = 0.25, n.top = 10, est.name = "Pearson.est", ties = FALSE) { - if (ties) { - plot.data <- EA$GSEA.Results.ties - significant.hits <- EA$GSEA.Results.ties[which(EA$GSEA.Results.ties$FDR_q_value < FDR), ] - } else { - plot.data <- EA$GSEA.Results - significant.hits <- EA$GSEA.Results[which(EA$GSEA.Results$FDR_q_value < FDR), ] - } - - if (nrow(plot.data[plot.data$p_value == 0, ]) > 0) { - plot.data[plot.data$p_value == 0, ]$p_value <- 0.00099 - } - - if (nrow(plot.data[plot.data$FDR_q_value == 0, ]) > 0) { - plot.data[plot.data$FDR_q_value == 0, ]$FDR_q_value <- 0.00099 - } - - # define x, y limits - limit.x <- ceiling(max(abs(as.numeric(plot.data$NES)), na.rm = TRUE)) - limit.y <- ceiling(max(-as.numeric(log(plot.data$p_value, 10)), na.rm = TRUE)) - - ## select results which meet FDR threshold and produce mountain plots - temp.plot <- list() - if (nrow(significant.hits) > 0) { - for (i in seq_len(nrow(significant.hits))) { - temp <- gsea_mountain_plot( - GSEA.list = EA, Sample.Name = est.name, - Gene.Set.A = significant.hits$Drug_set[i] - ) - temp.plot[significant.hits$Drug_set[i]] <- list(temp) - } - } else { - warning("No enrichments met the FDR cut-off to produce mountain plots") - } - - # categorize data by significance level if there are significant hits - if (nrow(significant.hits) > 0) { - plot.data$Significance <- paste0("FDR > ", FDR) - plot.data[plot.data$FDR_q_value < FDR, ]$Significance <- paste0("FDR < ", FDR) - plot.data$Significance <- factor(plot.data$Significance, - levels = c(paste0("FDR < ", FDR), - paste0("FDR > ", FDR))) - bar.data <- plot.data %>% slice_max(abs(NES), n=n.top) - bar.data <- bar.data[order(bar.data$NES),] - - volc <- ggplot2::ggplot(data = plot.data, aes( - x = NES, y = -log(p_value, 10), - color = Significance - )) + - ggplot2::geom_point(size = 4) + - ggrepel::geom_text_repel( - data = subset(plot.data, Significance == paste0("FDR < ", FDR)), - mapping = aes(label = Drug_set, size = I(6)), nudge_y = 0.25 - ) + - ggplot2::scale_color_manual( - values = c("red", "azure4"), name = "Significance", - breaks = c(paste0("FDR < ", FDR), paste0("FDR > ", FDR)) - ) + - ggplot2::xlim(-limit.x, limit.x) + - ggplot2::ylim(0, limit.y) + - ggplot2::xlab("Normalized Enrichment Score") + - ggplot2::ylab("-Log(p-value)") + - ggplot2::geom_vline(xintercept = 0, linetype = "solid", color = "grey", - linewidth = 0.5) + - ggplot2::theme( - panel.border = element_rect(colour = "black", fill = NA, linewidth = 1), - axis.line = element_line(colour = "black", linewidth = 0.65), - legend.text = element_text(size = 20), - axis.text = element_text(size = 20), - axis.title = element_text(size = 26, face = "bold"), - panel.background = element_rect( - fill = "white", colour = "white", linewidth = 0.5, - linetype = "solid", color = "black" - ), text = element_text(size = 20), - legend.position = "bottom", legend.key = element_blank() - ) - - bar <- ggplot2::ggplot(bar.data, aes(x=NES, y=Drug_set, fill = Significance)) + - geom_bar(stat='identity') + ggplot2::theme( - panel.border = element_rect(colour = "black", fill = NA, linewidth = 1), - axis.line = element_line(colour = "black", linewidth = 0.65), - legend.text = element_text(size = 20), - axis.text = element_text(size = 20), - axis.title = element_text(size = 26, face = "bold"), - panel.background = element_rect( - fill = "white", colour = "white", linewidth = 0.5, - linetype = "solid", color = "black" - ), text = element_text(size = 20), - legend.position = "bottom", legend.key = element_blank() - ) + ggplot2::xlab("Normalized Enrichment Score") + - ggplot2::ylab("") + - ggplot2::scale_fill_manual( - values = c("red", "azure4"), name = "Significance", - breaks = c(paste0("FDR < ", FDR), paste0("FDR > ", FDR)) - ) - } else { - plot.data$Significance <- paste0("FDR > ", FDR) - plot.data$Significance <- factor(plot.data$Significance, - levels = paste0("FDR > ", FDR)) - bar.data <- plot.data %>% slice_max(abs(NES), n=n.top) - bar.data <- bar.data[order(bar.data$NES),] - - volc <- ggplot2::ggplot(data = plot.data, - aes(x = NES, y = -log(p_value, 10))) + - ggplot2::geom_point(size = 4, color = "azure4") + - ggplot2::xlim(-limit.x, limit.x) + - ggplot2::ylim(0, limit.y) + - ggplot2::xlab("Normalized Enrichment Score") + - ggplot2::ylab("-Log(p-value)") + - ggplot2::geom_vline(xintercept = 0, linetype = "solid", color = "grey", - linewidth = 0.5) + - ggplot2::theme( - panel.border = element_rect(colour = "black", fill = NA, linewidth = 1), - axis.line = element_line(colour = "black", linewidth = 0.65), - legend.text = element_text(size = 20), - axis.text = element_text(size = 20), - axis.title = element_text(size = 26, face = "bold"), - panel.background = element_rect( - fill = "white", colour = "white", linewidth = 0.5, - linetype = "solid", color = "black" - ), text = element_text(size = 20), - legend.position = "bottom", legend.key = element_blank() - ) - - bar <- ggplot2::ggplot(bar.data, aes(x=NES, y=Drug_set, fill = Significance)) + - geom_bar(stat='identity') + ggplot2::theme( - panel.border = element_rect(colour = "black", fill = NA, linewidth = 1), - axis.line = element_line(colour = "black", linewidth = 0.65), - legend.text = element_text(size = 20), - axis.text = element_text(size = 20), - axis.title = element_text(size = 26, face = "bold"), - panel.background = element_rect( - fill = "white", colour = "white", linewidth = 0.5, - linetype = "solid", color = "black" - ), text = element_text(size = 20), - legend.position = "bottom", legend.key = element_blank() - ) + ggplot2::xlab("Normalized Enrichment Score") + - ggplot2::ylab("") + - ggplot2::scale_y_discrete(limits = bar.data[order(bar.data$NES, decreasing = TRUE), ]$Drug_set) + - ggplot2::scale_fill_manual( - values = c("azure4"), name = "Significance", - breaks = c(paste0("FDR > ", FDR)) - ) - } - bar.data$name <- est.name - bg.theme <- ggplot2::theme( - legend.background = element_rect(), legend.position = "top", - legend.text = element_text(size = 14), - legend.key = element_blank(), - legend.title = element_text(size = 16), - axis.title.x = element_text(size = 20), - axis.text.x = element_text(size = 16, colour = "black"), - axis.title.y = element_text(size = 20), - axis.text.y = element_text(size = 16, colour = "black"), - plot.title = element_text( - lineheight = .8, face = "bold", size = 36 - ), - panel.grid.major = element_blank(), - panel.grid.minor = element_blank(), - panel.border = element_rect(fill = NA), - panel.background = element_blank(), - axis.line = element_line(colour = "black"), - axis.ticks.x = element_line(colour = "black"), - axis.ticks.y = element_line(colour = "black") - ) - dot <- ggplot2::ggplot( - bar.data, - ggplot2::aes(x = name, y = Drug_set, color = NES, - size = -log10(FDR_q_value) - ) - ) + - ggplot2::geom_point() + - ggplot2::scale_y_discrete(limits = bar.data[order(bar.data$NES, decreasing = TRUE), ]$Drug_set) + - viridis::scale_color_viridis() + - bg.theme + - ggplot2::labs( - x = "", y = "", - color = "NES", size = "-log(FDR)" - ) - - if (ties) { - dot.sd <- ggplot2::ggplot( - bar.data, - ggplot2::aes(x = name, y = Drug_set, color = NES, - size = -log10(ES_sd) - ) - ) + - ggplot2::geom_point() + - ggplot2::scale_y_discrete(limits = bar.data[order(bar.data$NES, decreasing = TRUE), ]$Drug_set) + - viridis::scale_color_viridis() + - bg.theme + - ggplot2::labs( - x = "", y = "", - color = "NES", size = "-log(ES SD)" - ) - } else { - dot.sd <- NA - } - return(list(volcano = volc, bar = bar, mtn = temp.plot, dot = dot, dot.sd = dot.sd)) -} - -drugSAI <- function(data, gmt = NULL, drug = "Drug", - rank.metric = "Pearson.est", set.type = "moa", - direction.adjust = NULL, FDR = 0.25, - num.permutations = 1000, stat.type = "Weighted", - min.per.set = 6, n.top = 10, sep = "[|]", - exclusions = c("-666", "NA", "na", "NaN", "NULL"), - descriptions = NULL, convert.synonyms = FALSE, plots = TRUE, - ties = FALSE, marker.select=TRUE) { - # avoid unclear initialization - Drug_set <- NULL - NES <- NULL - Significance <- NULL - p_value <- NULL - - # check class of input is as expected - testthat::expect_is(data, "data.frame") - - ## remove any drugs with rank.metric = 0, NA - ## because signed ranks are required for enrichment analysis - data[, c(rank.metric)] <- as.numeric(data[, c(rank.metric)]) - data <- data[data[, c(rank.metric)] != 0 & !is.na(data[, c(rank.metric)]), ] - - ## check for duplicate entries for each drug - ## because only 1 rank metric is allowed per drug - drug.names <- unique(data[, c(drug)]) - if (length(drug.names) < nrow(data)) { - stop("each drug must have only 1 rank.metric value") - } - - ## if necessary, generate gmt object - if (is.null(gmt)) { - gmt <- as_gmt(data, - element.names = drug, set.names = set.type, - min.per.set, sep, exclusions, descriptions - ) - } - - ## if necessary, adjust rank metrics - if (length(direction.adjust) > 0) { - info <- dplyr::distinct(data[, c(drug, rank.metric, set.type)]) - info$adjust <- 1 - info[grep(direction.adjust, info[, c(set.type)], - value = TRUE), "adjust"] <- -1 - info$adjusted.est <- - as.numeric(info[, c(rank.metric)]) * as.numeric(info$adjust) - input <- info[, c(drug, "adjusted.est")] - est.name <- paste0(rank.metric, " direction-adjusted") - } else { - input <- data[, c(drug, rank.metric)] - est.name <- rank.metric - } - colnames(input) <- c(drug, est.name) - - ## perform enrichment analysis using GSEA_custom - message("Running enrichment analysis...") - EA <- GSEA_custom( - input, gmt, num.permutations, stat.type, - min.per.set, convert.synonyms, ties, marker.select - ) - if (ties) { - result <- EA$GSEA.Results.ties - result.w.ties <- EA$GSEA.Results - } else { - result <- EA$GSEA.Results - result.w.ties <- data.frame() - } - - if (plots) { - ## produce volcano and bar plots - sumPlots <- summaryPlots(EA, FDR = FDR, n.top = n.top, est.name = est.name, ties = ties) - } else { - sumPlots <- list("volcano" = NA, "bar" = NA, "mtn" = NA) - } - - return(list( - gmt = gmt, result = result, result.w.ties = result.w.ties, - mtn.plots = sumPlots$mtn, - volcano.plot = sumPlots$volcano, bar.plot = sumPlots$bar, - dot.plot = sumPlots$dot, dot.sd = sumPlots$dot.sd, - removed.sets = EA$removed.sets, - replaced.drugs = EA$replacements, - unannotated.drugs = EA$unannotated.drugs - )) -} diff --git a/R/drugSEA_ties.R b/R/drugSEA_ties.R deleted file mode 100755 index f9a7f4e..0000000 --- a/R/drugSEA_ties.R +++ /dev/null @@ -1,962 +0,0 @@ - -# load GSEA_custom function -GSEA_custom1 <- function(input.df, gmt.list, - nperm = 1000, - stat.type = "Weighted", min.per.set, - convert.synonyms = FALSE, ties = FALSE) { - GSEA.EnrichmentScore <- function(gene.list, gene.set, - weighted.score.type = score.weight, - correl.vector = NULL) { - tag.indicators <- sign(match(gene.list, gene.set, nomatch = 0)) - no.tag.indicator <- 1 - tag.indicators - N <- length(gene.list) - Nh <- sum(tag.indicators) - Nm <- N - Nh - if (weighted.score.type == 0) { - correl.vector <- rep(1, N) - } - alpha <- weighted.score.type - correl.vector <- abs(correl.vector**alpha) - sum.correl.tag <- sum(correl.vector[tag.indicators == 1]) - norm.tag <- 1.0 / sum.correl.tag - norm.no.tag <- 1.0 / Nm - RES <- - cumsum(tag.indicators * correl.vector * norm.tag - - no.tag.indicator * norm.no.tag) - max.ES <- max(RES) - min.ES <- min(RES) - if (max.ES > -min.ES) { - ES <- signif(max.ES, digits = 5) - arg.ES <- which.max(RES) - } else { - ES <- signif(min.ES, digits = 5) - arg.ES <- which.min(RES) - } - return(list( - ES = ES, - arg.ES = arg.ES, - RES = RES, - indicator = tag.indicators - )) - } - - # set weight for drug ranks - if (stat.type == "Classic") { - score.weight <- 0 - } else if (stat.type == "Weighted") { - score.weight <- 1 - } - - # find biggest drug set - biggest.set <- min.per.set - for (i in seq_len(length(gmt.list$genesets))) { - if (length(gmt.list$genesets[[i]]) > biggest.set) { - biggest.set <- length(gmt.list$genesets[[i]]) - } - } - - # restructure drug sets so that each MOA is a column with drugs in rows - # also generate list of all annotated drugs from gmt - Drug.Sets <- matrix( - data = "", nrow = biggest.set, - ncol = length(gmt.list$genesets) - ) - colnames(Drug.Sets) <- gmt.list$geneset.names - annotated.drugs <- c() - for (i in seq_len(ncol(Drug.Sets))) { - for (j in seq_len(length(gmt.list$genesets[[i]]))) { - Drug.Sets[j, i] <- gmt.list$genesets[[i]][[j]][1] - annotated.drugs <- c(annotated.drugs, gmt.list$genesets[[i]][[j]][1]) - } - } - Drug.Sets <- as.data.frame(Drug.Sets) - annotated.drugs <- unique(annotated.drugs) - - # check class of inputs is as expected - testthat::expect_is(input.df, "data.frame") - testthat::expect_is(Drug.Sets, "data.frame") - - Samples <- colnames(input.df)[2] - Drug.Sets.All <- colnames(Drug.Sets) - - annotations <- matrix( - data = 0, nrow = nrow(input.df), - ncol = length(Drug.Sets.All) - ) - colnames(annotations) <- Drug.Sets.All - - annotations <- as.data.frame(annotations) - - annotations <- cbind(input.df[, 1], annotations) - colnames(annotations) <- c(colnames(input.df)[1], Drug.Sets.All) - annotations <- as.matrix(annotations) - - # Find out how many cores are available - if (requireNamespace("parallel") & - requireNamespace("snow") & - requireNamespace("doSNOW")) { - cores <- parallel::detectCores() - if (cores[1] > 1) { - cl <- snow::makeCluster(cores[1] - 1) # cluster using all but 1 core - doSNOW::registerDoSNOW(cl) # register cluster - } - } - - num.hits.pathways <- as.data.frame(Drug.Sets.All) - num.hits.pathways$N_drugs <- NA - ### Annotate drug sets - for (j in seq_len(length(Drug.Sets.All))) { - temp.pathway <- Drug.Sets[, Drug.Sets.All[j]] - for (i in seq_len(nrow(annotations))) { - if (annotations[i, 1] %in% temp.pathway) { - annotations[i, j + 1] <- "X" - } - } - num.hits.pathways$N_drugs[j] <- - sum(annotations[, Drug.Sets.All[j]] == "X") - } - - ### Check if any drugs are not in any sets - unannotated.drugs <- c() - for (i in seq_len(nrow(annotations))) { - if (sum(annotations[i, 2:ncol(annotations)] == "X") == 0) { - unannotated.drugs <- c(unannotated.drugs, annotations[i, 1]) - } - } - - ### Check if these unannotated drug names are a synonym for an annotated drug - if (convert.synonyms) { - # access drug synonyms - synonyms <- utils::read.csv( - paste0("https://raw.github.com/BelindaBGarana/DMEA/", - "shiny-app/Inputs/PRISM_drug_synonyms.csv") - ) - replacements <- as.data.frame(unannotated.drugs) - replacements[, c("PRISM_drug_name", - "PubChem_CID", "PubChem_synonyms")] <- NA - for (i in seq_len(length(unannotated.drugs))) { - # check if unannotated drug name is a CID for a PRISM drug - if (unannotated.drugs[i] %in% synonyms$PubChem_CID) { - replacements[i, c("PRISM_drug_name", - "PubChem_CID", "PubChem_synonyms")] <- - synonyms[synonyms$PubChem_CID == unannotated.drugs[i], ] - } else { - # else check if unannotated drug is a synonym for a PRISM drug name - for (j in seq_len(nrow(synonyms))) { - temp.synonyms <- strsplit(synonyms$PubChem_synonyms[j], "[|]") - if (unannotated.drugs[i] %in% temp.synonyms) { - replacements[i, c("PRISM_drug_name", - "PubChem_CID", "PubChem_synonyms")] <- - synonyms[j, c("PRISM_drug_name", - "PubChem_CID", "PubChem_synonyms")] - break - } - } - } - } - unannotated.drugs <- - replacements[is.na(replacements$PRISM_drug_name), ]$unannotated.drugs - - # remove any drugs which were not replaced - replacements <- na.omit(replacements) - rm(synonyms) - - # replace drug names in rank list - for (i in seq_len(nrow(input.df))) { - if (input.df[i, 1] %in% replacements$unannotated.drugs) { - input.df[i, 1] <- - replacements[replacements$unannotated.drugs == input.df[i, 1], - ]$PRISM_drug_name - } - } - - # redo annotations - annotations <- matrix( - data = 0, nrow = nrow(input.df), - ncol = length(Drug.Sets.All) - ) - colnames(annotations) <- Drug.Sets.All - - annotations <- as.data.frame(annotations) - - annotations <- cbind(input.df[, 1], annotations) - colnames(annotations) <- c(colnames(input.df)[1], Drug.Sets.All) - annotations <- as.matrix(annotations) - - ### Annotate drug sets - for (j in seq_len(length(Drug.Sets.All))) { - temp.pathway <- Drug.Sets[, Drug.Sets.All[j]] - for (i in seq_len(nrow(annotations))) { - if (annotations[i, 1] %in% temp.pathway) { - annotations[i, j + 1] <- "X" - } - } - num.hits.pathways$N_drugs[j] <- - sum(annotations[, Drug.Sets.All[j]] == "X") - } - } else { - replacements <- NULL - } - unannotated.input <- input.df[input.df[, 1] %in% unannotated.drugs, ] - - Drug.Sets.under <- - num.hits.pathways[num.hits.pathways$N_drugs < min.per.set, ]$Drug.Sets.All - Drug.Sets.over <- - num.hits.pathways[num.hits.pathways$N_drugs >= min.per.set, - ]$Drug.Sets.All - if (length(Drug.Sets.under) > 0) { - warning(paste0( - "Removing drug sets with less than ", min.per.set, - " drugs observed in data set" - )) - annotations <- annotations[, c(colnames(input.df)[1], Drug.Sets.All)] - - # only keep drug sets with >= min.per.set drugs - Drug.Sets.All <- Drug.Sets.over - } - colnames(num.hits.pathways)[1] <- "Drug_set" - if (length(Drug.Sets.over) < 2) { - stop("annotations for 2+ drug sets are required") - } # BG 2022-06-25 - annotations <- as.data.frame(annotations) - input.df <- merge(input.df, annotations, by = colnames(input.df)[1]) - input.df <- stats::na.omit(input.df) - rm(annotations) - - GSEA.Results <- matrix(data = NA, nrow = length(Drug.Sets.All), ncol = 8) - colnames(GSEA.Results) <- c( - "Rank_metric", "Drug_set", "ES", "NES", - "p_value", "Position_at_max", "FDR_q_value", "Leading_edge" - ) - GSEA.Results <- as.data.frame(GSEA.Results) - GSEA.Results$Drug_set <- Drug.Sets.All - GSEA.Results$Rank_metric <- Samples - - ## Assuming first two columns in data table are drug names and - ## rank metric (e.g. Foldchange, SNR) - input.df[, Samples] <- as.numeric(as.character(input.df[, Samples])) - - # sort by descending order for the rank metric - input.df <- input.df[order(-input.df[, Samples]), ] - - # reorder row indices for counting in for loop below - rownames(input.df) <- seq_len(nrow(input.df)) - ions <- nrow(input.df) - - # for plotting - ks_results_plot <- list() - positions.of.hits <- list() - - gene.list <- seq_len(ions) - rank_metric <- input.df[, Samples] # Save the rank metric - - pos_gene_set <- array(data = 0, dim = nrow(input.df), dimnames = NULL) - - ## Calculate Real KS Statistic with original input - message("calculating ES with original input") - for (i in seq_len(length(Drug.Sets.All))) { - pos_gene_set <- which(input.df[, Drug.Sets.All[i]] %in% c("X")) - KS_real <- GSEA.EnrichmentScore(gene.list, pos_gene_set, - weighted.score.type = score.weight, - correl.vector = rank_metric - ) - - # store ES and positions - GSEA.Results[GSEA.Results$Drug_set == Drug.Sets.All[i], - ]$ES <- KS_real$ES - GSEA.Results[GSEA.Results$Drug_set == Drug.Sets.All[i], - ]$Position_at_max <- KS_real$arg.ES - ks_results_plot[[Drug.Sets.All[i]]] <- KS_real$RES - positions.of.hits[[Drug.Sets.All[i]]] <- pos_gene_set - - # identify leading edge elements - if (KS_real$ES <= 0) { - pos_leading_edge <- pos_gene_set[pos_gene_set >= KS_real$arg.ES] - } else if (KS_real$ES >= 0) { - pos_leading_edge <- pos_gene_set[pos_gene_set <= KS_real$arg.ES] - } - leading_edge <- input.df[pos_leading_edge, 1] - GSEA.Results[GSEA.Results$Drug_set == Drug.Sets.All[i], - ]$Leading_edge <- paste(leading_edge, collapse = ", ") - } - Mountain.Plot.Info <- list( - MountainPlot = ks_results_plot, - Position.of.hits = positions.of.hits - ) - rm(pos_gene_set) - rm(KS_real) - - ### tie permutations (NOT a null distribution) - if (ties) { - KSRandomArray_ties <- matrix(data = NA, nrow = nperm, - ncol = length(Drug.Sets.All)) - num.Drug.Sets.all <- length(Drug.Sets.All) - `%dopar%` <- foreach::`%dopar%` - message("calculating ES with shuffled ties") - KSRandomArray_ties <- foreach::foreach(L = seq_len(nperm), - .combine = "rbind") %dopar% { - # randomly jitter list to shuffle ties - temp.input <- input.df[order(-input.df[, Samples], jitter(-input.df[, Samples])),] - rownames(temp.input) <- seq_len(nrow(temp.input)) # adding in case random result is due to nonsequential rownames? - gene.list <- rownames(temp.input) - - temp.KSRandomArray <- matrix(data = NA, nrow = 1, - ncol = num.Drug.Sets.all) - for (i in seq_len(length(Drug.Sets.All))) { - pos_gene_set <- which(temp.input[, Drug.Sets.All[i]] %in% c("X")) - - # calculate ES with shuffled ties - temp.KSRandomArray[, i] <- GSEA.EnrichmentScore(gene.list, - pos_gene_set, - weighted.score.type = score.weight, - correl.vector = temp.input[, Samples] - )$ES - } - temp.KSRandomArray - } - colnames(KSRandomArray_ties) <- Drug.Sets.All - KSRandomArray_ties <- as.data.frame(KSRandomArray_ties) - - ### calculate ES & NES - # let ES = mean of ES tie distribution and NES = mean of NES tie distribution - GSEA.Results.ties <- matrix(data = NA, nrow = length(Drug.Sets.All), ncol = 11) - colnames(GSEA.Results.ties) <- c( - "Rank_metric", "Drug_set", "ES","ES_min","ES_max", "ES_sd", - "NES", "NES_min", "NES_max", "p_value", "FDR_q_value" - ) - GSEA.Results.ties <- as.data.frame(GSEA.Results.ties) - GSEA.Results.ties$Drug_set <- Drug.Sets.All - GSEA.Results.ties$Rank_metric <- Samples - GSEA.Results.ties$ES <- colMeans(KSRandomArray_ties, na.rm = TRUE) - GSEA.Results.ties$ES_min <- apply(KSRandomArray_ties, 2, min) - GSEA.Results.ties$ES_max <- apply(KSRandomArray_ties, 2, max) - GSEA.Results.ties$ES_sd <- apply(KSRandomArray_ties, 2, sd) - } - - ### MOA permutations (null distribution) - KSRandomArray <- matrix(data = NA, nrow = nperm, - ncol = length(Drug.Sets.All)) - num.Drug.Sets.all <- length(Drug.Sets.All) - `%dopar%` <- foreach::`%dopar%` - - KSRandomArray <- foreach::foreach(L = seq_len(nperm), - .combine = "rbind") %dopar% { - temp.KSRandomArray <- matrix(data = NA, nrow = 1, - ncol = num.Drug.Sets.all) - for (i in seq_len(length(Drug.Sets.All))) { - # randomly sample drug set of same size as original set - numhits_pathway <- length(positions.of.hits[[Drug.Sets.All[i]]]) - pos_gene_set <- sample(seq_len(ions), numhits_pathway) - - # calculate null enrichment score - temp.KSRandomArray[, i] <- GSEA.EnrichmentScore(gene.list, - pos_gene_set, - weighted.score.type = score.weight, - correl.vector = rank_metric - )$ES - } - temp.KSRandomArray - } - colnames(KSRandomArray) <- Drug.Sets.All - KSRandomArray <- as.data.frame(KSRandomArray) - - ### normalize the GSEA distribution - KSRandomArray.Norm <- matrix( - data = NA, nrow = nrow(KSRandomArray), - ncol = ncol(KSRandomArray) - ) - colnames(KSRandomArray.Norm) <- colnames(KSRandomArray) - KSRandomArray.temp <- 0 - for (i in seq_len(ncol(KSRandomArray.Norm))) { - KSRandomArray.temp <- KSRandomArray[, i] - pos.temp <- KSRandomArray.temp[which(KSRandomArray.temp >= 0)] - neg.temp <- - KSRandomArray.temp[which(KSRandomArray.temp <= 0)] # BG OR EQUAL TO - - avg.pos <- mean(pos.temp) - avg.neg <- mean(neg.temp) - - norm.pos.temp <- pos.temp / avg.pos - norm.neg.temp <- neg.temp / avg.neg * -1 - - norm.perms <- c(norm.pos.temp, norm.neg.temp) - - KSRandomArray.Norm[, i] <- norm.perms - } - - # Calculate GSEA NES and p-value - for (i in seq_len(length(Drug.Sets.All))) { - temp.gene.set <- Drug.Sets.All[i] - temp.perms <- KSRandomArray[, temp.gene.set] - temp.ES <- GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$ES - if (ties) { - temp.ES.tie <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$ES - temp.ES.tie.min <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$ES_min - temp.ES.tie.max <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$ES_max - } - pos.perms <- temp.perms[which(temp.perms >= 0)] # BG OR EQUAL TO - neg.perms <- temp.perms[which(temp.perms <= 0)] # BG OR EQUAL TO - - # original input order - if (temp.ES >= 0) { # BG OR EQUAL TO - # p-value - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$p_value <- - signif(sum(pos.perms >= temp.ES) / - length(pos.perms), digits = 3) # BG OR EQUAL TO - - # NES - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES <- - signif(temp.ES / mean(pos.perms), digits = 3) - } else { # BG OR EQUAL TO - # p-value - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$p_value <- - signif(sum(neg.perms <= temp.ES) / - length(neg.perms), digits = 3) # BG OR EQUAL TO - - # NES - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES <- - signif(temp.ES / mean(neg.perms) * -1, digits = 3) - } - - # shuffled ties - if (ties) { - if (temp.ES.tie >= 0) { - # p-value - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$p_value <- - signif(sum(pos.perms >= temp.ES.tie.min) / - length(pos.perms), digits = 3) - - # NES - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES <- - signif(temp.ES.tie / mean(pos.perms), digits = 3) - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_min <- - signif(temp.ES.tie.min / mean(pos.perms), digits = 3) - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_max <- - signif(temp.ES.tie.max / mean(pos.perms), digits = 3) - } else { # BG OR EQUAL TO - # p-val - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$p_value <- - signif(sum(neg.perms <= temp.ES) / - length(neg.perms), digits = 3) # BG OR EQUAL TO - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$p_value <- - signif(sum(neg.perms <= temp.ES.tie.max) / - length(neg.perms), digits = 3) - - # NES - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES <- - signif(temp.ES.tie / mean(neg.perms) * -1, digits = 3) - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_min <- - signif(temp.ES.tie.min / mean(neg.perms) * -1, digits = 3) - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_max <- - signif(temp.ES.tie.max / mean(neg.perms) * -1, digits = 3) - } - } - } - - # Calculate GSEA FDR - GSEA.Results <- GSEA.Results[!is.na(GSEA.Results$NES),] - GSEA.NES.perms <- as.vector(KSRandomArray.Norm[,GSEA.Results$Drug_set]) - rm(KSRandomArray.Norm) - GSEA.NES.perms.pos <- GSEA.NES.perms[which(GSEA.NES.perms >= 0)] - GSEA.NES.perms.neg <- - GSEA.NES.perms[which(GSEA.NES.perms <= 0)] # BG OR EQUAL TO - rm(GSEA.NES.perms) - for (i in seq_len(length(GSEA.Results$Drug_set))) { - temp.gene.set <- GSEA.Results$Drug_set[i] - temp.NES <- GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES - if (ties) { - temp.NES.tie <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES - temp.NES.tie.min <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_min - temp.NES.tie.max <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_max - } - - # results for original input - if (temp.NES >= 0) { # BG OR EQUAL TO - percent.temp <- - sum(GSEA.NES.perms.pos >= - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES) / - length(GSEA.NES.perms.pos) # BG OR EQUAL TO - percent.pos.stronger <- - sum(GSEA.Results$NES >= - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES) / - sum(GSEA.Results$NES >= 0) # BG - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$FDR_q_value <- - ifelse(signif(percent.temp / percent.pos.stronger, digits = 3) < 1, - signif(percent.temp / percent.pos.stronger, digits = 3), 1 - ) # BG - } else { # BG OR EQUAL TO - percent.temp <- sum(GSEA.NES.perms.neg <= temp.NES) / - length(GSEA.NES.perms.neg) # BG OR EQUAL TO - percent.neg.stronger <- sum(GSEA.Results$NES <= temp.NES) / - sum(GSEA.Results$NES <= 0) # BG - GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$FDR_q_value <- - ifelse(signif(percent.temp / percent.neg.stronger, digits = 3) < 1, - signif(percent.temp / percent.neg.stronger, digits = 3), 1 - ) # BG - } - - # results for shuffled ties - if (ties) { - if (temp.NES.tie >= 0) { - percent.temp <- - sum(GSEA.NES.perms.pos >= temp.NES.tie.min) / length(GSEA.NES.perms.pos) # BG OR EQUAL TO - percent.pos.stronger <- - sum(GSEA.Results.ties$NES_max >= temp.NES.tie.min) / sum(GSEA.Results.ties$NES >= 0) # BG - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$FDR_q_value <- - ifelse(signif(percent.temp / percent.pos.stronger, digits = 3) < 1, - signif(percent.temp / percent.pos.stronger, digits = 3), 1 - ) # BG - } else { - percent.temp <- sum(GSEA.NES.perms.neg <= temp.NES.tie.max) / length(GSEA.NES.perms.neg) # BG OR EQUAL TO - percent.neg.stronger <- sum(GSEA.Results.ties$NES_min <= temp.NES.tie.max) / sum(GSEA.Results.ties$NES <= 0) # BG - GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$FDR_q_value <- - ifelse(signif(percent.temp / percent.neg.stronger, digits = 3) < 1, - signif(percent.temp / percent.neg.stronger, digits = 3), 1 - ) # BG - } - } - } - - if (requireNamespace("parallel") & - requireNamespace("snow") & - requireNamespace("doSNOW")) { - if (cores[1] > 1) { - snow::stopCluster(cl) # stop cluster - rm(cl) - } - } - - if (!ties) { - GSEA.Results.ties <- data.frame() - } - - return(list( - GSEA.Results = GSEA.Results, - GSEA.Results.ties = GSEA.Results.ties, - Mountain.Plot.Info = Mountain.Plot.Info, - ranking.metric = rank_metric, - removed.sets = - num.hits.pathways[num.hits.pathways$N_drugs < min.per.set, ], - replacements = replacements, - unannotated.drugs = unannotated.input - )) -} - -# load mountain plot function -gsea_mountain_plot <- function(GSEA.list, Sample.Name, Gene.Set.A, - color = TRUE) { - if (color) { - color.palette <- c("red") - } else if (!color) { - color.palette <- c("black") - } - - GSEA.list <- GSEA.list - plotting.info <- GSEA.list$Mountain.Plot.Info - ES_profiles <- plotting.info$MountainPlot - position.of.hits <- plotting.info$Position.of.hits - - ranking.metric <- as.numeric(GSEA.list$ranking.metric) - - ES_GeneSetA <- ES_profiles[[Gene.Set.A]] - - pos.GeneSetA <- position.of.hits[[Gene.Set.A]] - - myName <- Gene.Set.A - - GSEA.results <- GSEA.list$GSEA.Results - GSEA.results <- GSEA.results[GSEA.results$Rank_metric == Sample.Name, ] - GSEA.results$p_value <- as.numeric(as.character(GSEA.results$p_value)) - GSEA.results$FDR_q_value <- as.numeric(as.character(GSEA.results$FDR_q_value)) - - gsea.normalized.enrichment.score <- - signif(GSEA.results[GSEA.results$Drug_set == myName, ]$NES, digits = 3) - gsea.p.value <- - signif(GSEA.results[GSEA.results$Drug_set == myName, ]$p_value, - digits = 3) - gsea.q.val <- - signif(GSEA.results[GSEA.results$Drug_set == myName, ]$FDR_q_value, - digits = 3) - - results.as.text <- paste( - "NES", gsea.normalized.enrichment.score, "\np-value:", gsea.p.value, - "\nq-value:", gsea.q.val - ) - - gsea.hit.indices.A <- pos.GeneSetA - - gsea.es.profile.A <- ES_GeneSetA[gsea.hit.indices.A] - - ngenes <- length(ES_GeneSetA) - combined.ES <- c(ES_GeneSetA) - max.ES <- max(combined.ES) - min.ES <- min(combined.ES) - - mtn.plot <- NULL - mtn.plot <- ggplot2::ggplot() + - ggplot2::geom_line( - ggplot2::aes( - x = c(0, pos.GeneSetA, ngenes), - y = c(0, gsea.es.profile.A, 0) - ), - color = color.palette[1], size = 1 - ) + - ggplot2::labs(x = NULL, y = "ES", title = myName) + - ggplot2::scale_x_continuous(expand = c(0, 0)) + - ggplot2::theme_bw() + - ggplot2::geom_hline(yintercept = 0, linetype = "dashed", - color = "grey50") + - ggplot2::theme( - axis.text.x = ggplot2::element_blank(), - axis.ticks.x = ggplot2::element_blank(), - axis.ticks.length = ggplot2::unit(0, "pt"), - axis.title.x = ggplot2::element_blank(), - panel.grid = ggplot2::element_blank(), - plot.background = ggplot2::element_blank(), - plot.margin = ggplot2::unit(c(0, 0, 0, 0), "cm"), - plot.title = ggplot2::element_text(hjust = 0.5) - ) - - if (!is.null(gsea.normalized.enrichment.score) & - length(gsea.normalized.enrichment.score) > 0) { - if (gsea.normalized.enrichment.score > 0) { - mtn.plot <- mtn.plot + ggplot2::annotate("text", - label = results.as.text, x = ngenes * 0.90, - y = max.ES * 0.70, color = "black" - ) - } else if (gsea.normalized.enrichment.score < 0) { - mtn.plot <- mtn.plot + ggplot2::annotate("text", - label = results.as.text, x = ngenes * 0.10, - y = min.ES * 0.30, color = "black" - ) - } - } - - hit.markers <- ggplot2::ggplot() + - cowplot::theme_nothing() + - ggplot2::theme(panel.border = ggplot2::element_rect(color = "black", - fill = NA)) + - ggplot2::geom_col(ggplot2::aes(x = pos.GeneSetA, y = 1), - color = color.palette[1], - fill = color.palette[1], width = 0.75 - ) + - ggplot2::labs(x = NULL, y = NULL) + - ggplot2::scale_y_continuous(expand = c(0, 0)) + - aplot::xlim2(mtn.plot) - - show.rank.metric <- ggplot2::ggplot() + - ggplot2::geom_line(ggplot2::aes( - x = seq_len(ngenes), - y = ranking.metric - ), color = "grey50") + - ggplot2::geom_area(ggplot2::aes( - x = seq_len(ngenes), - y = ranking.metric - ), fill = "grey50") + - ggplot2::labs(x = "Rank", y = "Rank Metric") + - ggplot2::theme_bw() + - ggplot2::theme( - panel.grid = ggplot2::element_blank(), - plot.title = ggplot2::element_blank(), - plot.margin = ggplot2::unit(c(0, 0, 0, 0), "cm") - ) + - aplot::xlim2(mtn.plot) - - assembled <- mtn.plot + hit.markers + show.rank.metric + - patchwork::plot_layout(ncol = 1, heights = c(2.5, 0.5, 2)) - return(assembled) -} - -summaryPlots <- function(EA, FDR = 0.25, n.top = 10, est.name = "Pearson.est", ties = FALSE) { - if (ties) { - plot.data <- na.omit(EA$GSEA.Results.ties) - significant.hits <- na.omit(EA$GSEA.Results.ties[which(EA$GSEA.Results.ties$FDR_q_value < FDR), ]) - } else { - plot.data <- na.omit(EA$GSEA.Results) - significant.hits <- na.omit(EA$GSEA.Results[which(EA$GSEA.Results$FDR_q_value < FDR), ]) - } - - if (nrow(plot.data) > 0) { - if (nrow(plot.data[plot.data$p_value == 0, ]) > 0) { - plot.data[plot.data$p_value == 0, ]$p_value <- 0.00099 - } - - if (nrow(plot.data[plot.data$FDR_q_value == 0, ]) > 0) { - plot.data[plot.data$FDR_q_value == 0, ]$FDR_q_value <- 0.00099 - } - - # define x, y limits - limit.x <- ceiling(max(abs(as.numeric(plot.data$NES)), na.rm = TRUE)) - limit.y <- ceiling(max(-as.numeric(log(plot.data$p_value, 10)), na.rm = TRUE)) - - ## select results which meet FDR threshold and produce mountain plots - temp.plot <- list() - if (nrow(significant.hits) > 0) { - for (i in seq_len(nrow(significant.hits))) { - temp <- gsea_mountain_plot( - GSEA.list = EA, Sample.Name = est.name, - Gene.Set.A = significant.hits$Drug_set[i] - ) - temp.plot[significant.hits$Drug_set[i]] <- list(temp) - } - } else { - warning("No enrichments met the FDR cut-off to produce mountain plots") - } - - # categorize data by significance level if there are significant hits - if (any(plot.data$FDR_q_value < FDR)) { - plot.data$Significance <- paste0("FDR > ", FDR) - plot.data[plot.data$FDR_q_value < FDR, ]$Significance <- paste0("FDR < ", FDR) - plot.data$Significance <- factor(plot.data$Significance, - levels = c(paste0("FDR < ", FDR), - paste0("FDR > ", FDR))) - bar.data <- plot.data %>% slice_max(abs(NES), n=n.top) - bar.data <- bar.data[order(bar.data$NES),] - - volc <- ggplot2::ggplot(data = plot.data, aes( - x = NES, y = -log(p_value, 10), - color = Significance - )) + - ggplot2::geom_point(size = 4) + - ggrepel::geom_text_repel( - data = subset(plot.data, Significance == paste0("FDR < ", FDR)), - mapping = aes(label = Drug_set, size = I(6)), nudge_y = 0.25 - ) + - ggplot2::scale_color_manual( - values = c("red", "azure4"), name = "Significance", - breaks = c(paste0("FDR < ", FDR), paste0("FDR > ", FDR)) - ) + - ggplot2::xlim(-limit.x, limit.x) + - ggplot2::ylim(0, limit.y) + - ggplot2::xlab("Normalized Enrichment Score") + - ggplot2::ylab("-Log(p-value)") + - ggplot2::geom_vline(xintercept = 0, linetype = "solid", color = "grey", - linewidth = 0.5) + - ggplot2::theme( - panel.border = element_rect(colour = "black", fill = NA, linewidth = 1), - axis.line = element_line(colour = "black", linewidth = 0.65), - legend.text = element_text(size = 20), - axis.text = element_text(size = 20), - axis.title = element_text(size = 26, face = "bold"), - panel.background = element_rect( - fill = "white", colour = "white", linewidth = 0.5, - linetype = "solid", color = "black" - ), text = element_text(size = 20), - legend.position = "bottom", legend.key = element_blank() - ) - - bar <- ggplot2::ggplot(bar.data, aes(x=NES, y=Drug_set, fill = Significance)) + - geom_bar(stat='identity') + ggplot2::theme( - panel.border = element_rect(colour = "black", fill = NA, linewidth = 1), - axis.line = element_line(colour = "black", linewidth = 0.65), - legend.text = element_text(size = 20), - axis.text = element_text(size = 20), - axis.title = element_text(size = 26, face = "bold"), - panel.background = element_rect( - fill = "white", colour = "white", linewidth = 0.5, - linetype = "solid", color = "black" - ), text = element_text(size = 20), - legend.position = "bottom", legend.key = element_blank() - ) + ggplot2::xlab("Normalized Enrichment Score") + - ggplot2::ylab("") + - ggplot2::scale_fill_manual( - values = c("red", "azure4"), name = "Significance", - breaks = c(paste0("FDR < ", FDR), paste0("FDR > ", FDR)) - ) - } else { - plot.data$Significance <- paste0("FDR > ", FDR) - plot.data$Significance <- factor(plot.data$Significance, - levels = paste0("FDR > ", FDR)) - bar.data <- plot.data %>% slice_max(abs(NES), n=n.top) - bar.data <- bar.data[order(bar.data$NES),] - - volc <- ggplot2::ggplot(data = plot.data, - aes(x = NES, y = -log(p_value, 10))) + - ggplot2::geom_point(size = 4, color = "azure4") + - ggplot2::xlim(-limit.x, limit.x) + - ggplot2::ylim(0, limit.y) + - ggplot2::xlab("Normalized Enrichment Score") + - ggplot2::ylab("-Log(p-value)") + - ggplot2::geom_vline(xintercept = 0, linetype = "solid", color = "grey", - linewidth = 0.5) + - ggplot2::theme( - panel.border = element_rect(colour = "black", fill = NA, linewidth = 1), - axis.line = element_line(colour = "black", linewidth = 0.65), - legend.text = element_text(size = 20), - axis.text = element_text(size = 20), - axis.title = element_text(size = 26, face = "bold"), - panel.background = element_rect( - fill = "white", colour = "white", linewidth = 0.5, - linetype = "solid", color = "black" - ), text = element_text(size = 20), - legend.position = "bottom", legend.key = element_blank() - ) - - bar <- ggplot2::ggplot(bar.data, aes(x=NES, y=Drug_set, fill = Significance)) + - geom_bar(stat='identity') + ggplot2::theme( - panel.border = element_rect(colour = "black", fill = NA, linewidth = 1), - axis.line = element_line(colour = "black", linewidth = 0.65), - legend.text = element_text(size = 20), - axis.text = element_text(size = 20), - axis.title = element_text(size = 26, face = "bold"), - panel.background = element_rect( - fill = "white", colour = "white", linewidth = 0.5, - linetype = "solid", color = "black" - ), text = element_text(size = 20), - legend.position = "bottom", legend.key = element_blank() - ) + ggplot2::xlab("Normalized Enrichment Score") + - ggplot2::ylab("") + - ggplot2::scale_y_discrete(limits = bar.data[order(bar.data$NES, decreasing = TRUE), ]$Drug_set) + - ggplot2::scale_fill_manual( - values = c("azure4"), name = "Significance", - breaks = c(paste0("FDR > ", FDR)) - ) - } - bar.data$name <- est.name - bg.theme <- ggplot2::theme( - legend.background = element_rect(), legend.position = "top", - legend.text = element_text(size = 14), - legend.key = element_blank(), - legend.title = element_text(size = 16), - axis.title.x = element_text(size = 20), - axis.text.x = element_text(size = 16, colour = "black"), - axis.title.y = element_text(size = 20), - axis.text.y = element_text(size = 16, colour = "black"), - plot.title = element_text( - lineheight = .8, face = "bold", size = 36 - ), - panel.grid.major = element_blank(), - panel.grid.minor = element_blank(), - panel.border = element_rect(fill = NA), - panel.background = element_blank(), - axis.line = element_line(colour = "black"), - axis.ticks.x = element_line(colour = "black"), - axis.ticks.y = element_line(colour = "black") - ) - dot <- ggplot2::ggplot( - bar.data, - ggplot2::aes(x = name, y = Drug_set, color = NES, - size = -log10(FDR_q_value) - ) - ) + - ggplot2::geom_point() + - ggplot2::scale_y_discrete(limits = bar.data[order(bar.data$NES, decreasing = TRUE), ]$Drug_set) + - viridis::scale_color_viridis() + - bg.theme + - ggplot2::labs( - x = "", y = "", - color = "NES", size = "-log(FDR)" - ) - - if (ties) { - dot.sd <- ggplot2::ggplot( - bar.data, - ggplot2::aes(x = name, y = Drug_set, color = NES, - size = -log10(ES_sd) - ) - ) + - ggplot2::geom_point() + - ggplot2::scale_y_discrete(limits = bar.data[order(bar.data$NES, decreasing = TRUE), ]$Drug_set) + - viridis::scale_color_viridis() + - bg.theme + - ggplot2::labs( - x = "", y = "", - color = "NES", size = "-log(ES SD)" - ) - } else { - dot.sd <- NA - } - } else { - volc <- NA - bar <- NA - temp.plot <- list() - dot <- NA - dot.sd <- NA - } - return(list(volcano = volc, bar = bar, mtn = temp.plot, dot = dot, dot.sd = dot.sd)) -} - -drugSEA_ties <- function(data, gmt = NULL, drug = "Drug", - rank.metric = "Pearson.est", set.type = "moa", - direction.adjust = NULL, FDR = 0.25, - num.permutations = 1000, stat.type = "Weighted", - min.per.set = 6, n.top = 10, sep = "[|]", - exclusions = c("-666", "NA", "na", "NaN", "NULL"), - descriptions = NULL, convert.synonyms = FALSE, plots = TRUE, - ties = FALSE) { - # avoid unclear initialization - Drug_set <- NULL - NES <- NULL - Significance <- NULL - p_value <- NULL - - # check class of input is as expected - testthat::expect_is(data, "data.frame") - - ## remove any drugs with rank.metric = 0, NA - ## because signed ranks are required for enrichment analysis - data[, c(rank.metric)] <- as.numeric(data[, c(rank.metric)]) - data <- data[data[, c(rank.metric)] != 0 & !is.na(data[, c(rank.metric)]), ] - - ## check for duplicate entries for each drug - ## because only 1 rank metric is allowed per drug - drug.names <- unique(data[, c(drug)]) - if (length(drug.names) < nrow(data)) { - stop("each drug must have only 1 rank.metric value") - } - - ## if necessary, generate gmt object - if (is.null(gmt)) { - gmt <- as_gmt(data, - element.names = drug, set.names = set.type, - min.per.set, sep, exclusions, descriptions - ) - } - - ## if necessary, adjust rank metrics - if (length(direction.adjust) > 0) { - info <- dplyr::distinct(data[, c(drug, rank.metric, set.type)]) - info$adjust <- 1 - info[grep(direction.adjust, info[, c(set.type)], - value = TRUE), "adjust"] <- -1 - info$adjusted.est <- - as.numeric(info[, c(rank.metric)]) * as.numeric(info$adjust) - input <- info[, c(drug, "adjusted.est")] - est.name <- paste0(rank.metric, " direction-adjusted") - } else { - input <- data[, c(drug, rank.metric)] - est.name <- rank.metric - } - colnames(input) <- c(drug, est.name) - - ## perform enrichment analysis using GSEA_custom - message("Running enrichment analysis...") - EA <- GSEA_custom1( - input, gmt, num.permutations, stat.type, - min.per.set, convert.synonyms, ties - ) - if (ties) { - result <- EA$GSEA.Results.ties - result.w.ties <- EA$GSEA.Results - } else { - result <- EA$GSEA.Results - result.w.ties <- data.frame() - } - - if (plots) { - ## produce volcano and bar plots - sumPlots <- summaryPlots(EA, FDR = FDR, n.top = n.top, est.name = est.name, ties = ties) - } else { - sumPlots <- list("volcano" = NA, "bar" = NA, "mtn" = NA) - } - - return(list( - gmt = gmt, result = result, result.w.ties = result.w.ties, - mtn.plots = sumPlots$mtn, - volcano.plot = sumPlots$volcano, bar.plot = sumPlots$bar, - dot.plot = sumPlots$dot, dot.sd = sumPlots$dot.sd, - removed.sets = EA$removed.sets, - replaced.drugs = EA$replacements, - unannotated.drugs = EA$unannotated.drugs - )) -} diff --git a/R/mDEG.R b/R/mDEG.R old mode 100755 new mode 100644 index 74bacd6..67d16a1 --- a/R/mDEG.R +++ b/R/mDEG.R @@ -1,28 +1,20 @@ -mDEG <- function(data.list, factor.info, - feature.names = rep("Gene", length(data.list)), p = 0.05, +mDEG <- function(data.list, types, group.names = c("Diseased", "Healthy"), + group.samples = list( + 2:(0.5 * (ncol(data.list[[1]]) + 1)), + (0.5 * (ncol(data.list[[1]]) + 1) + 1):ncol(data.list[[1]]) + ), group.names2 = NULL, group.samples2 = NULL, + feature.names = rep("Gene", length(types)), p = 0.05, FDR.features = 0.05, n.dot.features = 10) { #### Step 1. Check if formats are correct #### # check that there are as many types as data.list inputs - if (length(feature.names) != length(data.list)) { - stop("Length of feature.names vector must match that of data.list") + if (length(types) != length(data.list)) { + stop("Length of types vector must match that of data.list") } - types <- names(data.list) - + #### Step 2. Differential expression analysis #### - if (length(levels(factor.info[,1])) != 2) { - stop("Exactly 2 levels are required for the first column of factor.info") + if (length(group.names) != 2) { + stop("Only 2 groups are allowed for differential expression analysis") } else { - # use parallel computing if possible - if (requireNamespace("parallel") & - requireNamespace("snow") & - requireNamespace("doSNOW")) { - cores <- parallel::detectCores() # number of cores available - if (cores[1] > 1) { - cl <- snow::makeCluster(cores[1] - 1) # cluster using all but 1 core - doSNOW::registerDoSNOW(cl) # register cluster - } - } - deg <- list() for (i in 1:length(types)) { # make sure there are no duplicated feature names @@ -32,18 +24,60 @@ mDEG <- function(data.list, factor.info, "for each feature" )) } else { - # select annotated samples and set feature names as rownames - all.data.list <- data.list[[i]][,rownames(factor.info)] + ## separate data.list based on group (i.e., categorical phenotype) + # get column names for first set of groups + data.list1 <- as.data.frame(data.list[[i]][, group.samples[[1]]]) + cols1 <- colnames(data.list1) + data.list2 <- as.data.frame(data.list[[i]][, group.samples[[2]]]) + cols2 <- colnames(data.list2) + if (!is.null(group.names2) & !is.null(group.samples2)) { + # get column names for second set of groups + data.list1a <- as.data.frame(data.list[[i]][, group.samples2[[1]]]) + data.list2a <- as.data.frame(data.list[[i]][, group.samples2[[2]]]) + + # make sure samples have annotations for both sets of groups + cols1a <- colnames(data.list1a) + cols2a <- colnames(data.list2a) + cols1 <- cols1[cols1 %in% c(cols1a, cols2a)] + cols2 <- cols2[cols2 %in% c(cols1a, cols2a)] + + # refine data lists to shared samples + data.list1a <- NULL + data.list2a <- NULL + data.list1 <- data.list1[, cols1] + data.list2 <- data.list2[, cols2] + + # store group annotations + cols <- c(cols1, cols2) + factor.info <- as.data.frame(cols) + factor.info$f1 <- factor(c(rep(0, ncol(data.list1)), rep(1, ncol(data.list2)))) + levels(factor.info$f1) <- make.names(group.names) + factor.info$f2 <- NA + factor.info[factor.info$cols %in% cols1a, ]$f2 <- 0 + factor.info[factor.info$cols %in% cols2a, ]$f2 <- 1 + factor.info$f2 <- as.factor(factor.info$f2) + levels(factor.info$f2) <- make.names(group.names2) + factor.info <- na.omit(factor.info) + } else { + # store group annotations + cols <- c(cols1, cols2) + factor.info <- as.data.frame(cols) + factor.info$f1 <- factor(c(rep(0, ncol(data.list1)), rep(1, ncol(data.list2)))) + levels(factor.info$f1) <- make.names(group.names) + } + + # combine data and set feature names as rownames + all.data.list <- cbind(data.list1, data.list2) rownames(all.data.list) <- data.list[[i]][ , feature.names[i]] - + # create expression sets eset <- Biobase::ExpressionSet(as.matrix(all.data.list)) - + # log2 transformation if distribution isn't normal ex <- Biobase::exprs(eset) qx <- as.numeric(quantile(ex, c(0., 0.25, 0.5, 0.75, 0.99, 1.0), - na.rm = TRUE + na.rm = TRUE )) LogC <- (qx[5] > 100) || (qx[6] - qx[1] > 50 && qx[2] > 0) @@ -51,51 +85,32 @@ mDEG <- function(data.list, factor.info, ex[which(ex <= 0)] <- NaN Biobase::exprs(eset) <- log2(ex) } - + # identify sample phenotypes and set up design matrix - eset$group <- factor.info[,1] - #levels(eset$group) <- levels(factor.info[,1]) - if (ncol(factor.info) == 2) { - eset$batch <- factor.info[,2] - levels(eset$batch) <- levels(factor.info[,2]) + eset$group <- factor.info$f1 + if (!is.null(group.names2) & !is.null(group.samples2)) { + eset$batch <- factor.info$f2 design <- stats::model.matrix(~ group + batch + 0, eset) - colnames(design)[1:2] <- make.names(substr(colnames(design)[1:2], 6, nchar(colnames(design)[1:2]))) - } else if (ncol(factor.info) == 1) { + colnames(design)[1:2] <- levels(eset$group) + } else { design <- stats::model.matrix(~ group + 0, eset) - colnames(design) <- make.names(substr(colnames(design), 6, nchar(colnames(design)))) - } else if (ncol(factor.info) == 3) { - eset$batch <- factor.info[,2] - eset$batch2 <- factor.info[,3] - levels(eset$batch) <- levels(factor.info[,2]) - levels(eset$batch2) <- levels(factor.info[,3]) - design <- stats::model.matrix(~ group + batch + batch2 + 0, eset) - colnames(design)[1:3] <- make.names(substr(colnames(design)[1:3], 6, nchar(colnames(design)[1:3]))) - } else if (ncol(factor.info) > 3) { - eset$batch <- factor.info[,2] - eset$batch2 <- factor.info[,3] - eset$batch3 <- factor.info[,4] - levels(eset$batch) <- levels(factor.info[,2]) - levels(eset$batch2) <- levels(factor.info[,3]) - levels(eset$batch3) <- levels(factor.info[,4]) - design <- stats::model.matrix(~ group + batch + batch2 + batch3 + 0, eset) - colnames(design)[1:4] <- make.names(substr(colnames(design)[1:4], 6, nchar(colnames(design)[1:4]))) + colnames(design) <- levels(eset$group) } - + # fit linear model fit <- limma::lmFit(eset, design) - + # set up contrasts of interest and redo fit - cts <- paste(levels(factor.info[,1]), collapse = "-") + cts <- paste(colnames(design)[1:2], collapse = "-") cont.matrix <- limma::makeContrasts(contrasts = cts, levels = design) fit <- limma::contrasts.fit(fit, cont.matrix) - + # calculate differential expression and statistics fit <- limma::eBayes(fit, 0.01) deg[[types[i]]] <- limma::topTable(fit, - adjust = "fdr", - number = nrow(fit) + adjust = "fdr", + number = nrow(fit) ) - deg[[types[i]]][, feature.names[i]] <- rownames(deg[[types[i]]]) colnames(deg[[types[i]]])[1] <- "Log2FC" deg[[types[i]]] <- @@ -110,31 +125,16 @@ mDEG <- function(data.list, factor.info, } } - # compile DEG results across omics types if less than all of them are phospho - if (any(grepl("phospho", names(deg), ignore.case = TRUE))) { - compileDEGs <- all(grepl("phospho", names(deg), ignore.case = TRUE)) - } else { - compileDEGs <- TRUE - } - if (length(types) > 1 & compileDEGs) { + # compile DEG results across omics types + if (length(types) > 1) { compiled.DEGs <- panSEA::compile_mDEG(deg, p, FDR.features, n.dot.features) } else { compiled.DEGs <- NA } - - # stop cluster if relevant - if (requireNamespace("parallel") & - requireNamespace("snow") & - requireNamespace("doSNOW")) { - if (cores[1] > 1) { - snow::stopCluster(cl) # stop cluster - rm(cl) - } - } - - return(list(compiled.results = compiled.DEGs, all.results = deg - )) + + return(list(compiled.results = compiled.DEGs, all.results = deg + )) } } diff --git a/R/mDMEA.R b/R/mDMEA.R old mode 100755 new mode 100644 index bd1dfed..d79e5e4 --- a/R/mDMEA.R +++ b/R/mDMEA.R @@ -13,7 +13,7 @@ mDMEA <- function(drug.sensitivity = "PRISM", gmt = "PRISM", scatter.plot.type = "pearson", FDR.scatter.plots = 0.05, xlab = "Weighted Voting Score", ylab = value, position.x = "min", position.y = "min", se = TRUE, - n.dot.sets = 10, ties = FALSE) { + n.dot.sets = 10) { #### Step 1. Load data if necessary #### # get drug.sensitivity, gmt, and expression if PRISM/CCLE if (is.character(drug.sensitivity)) { @@ -99,7 +99,7 @@ mDMEA <- function(drug.sensitivity = "PRISM", gmt = "PRISM", for (i in 1:length(types)) { message(paste("Running DMEA using", types[i], "data")) - DMEA.list[[types[i]]] <- panSEA::DMEA( + DMEA.list[[types[i]]] <- DMEA::DMEA( drug.sensitivity, gmt, expression[[i]], weights[[i]], value, sample.names, feature.names[i], weight.values[i], @@ -109,7 +109,7 @@ mDMEA <- function(drug.sensitivity = "PRISM", gmt = "PRISM", descriptions, min.per.corr, scatter.plots, scatter.plot.type, FDR.scatter.plots, xlab, ylab, - position.x, position.y, se, ties + position.x, position.y, se ) # merge correlation results with drug annotations if !is.null(drug.info) diff --git a/R/mDMEA_cell_corr.R b/R/mDMEA_cell_corr.R old mode 100755 new mode 100644 index f6d0f39..a65c2aa --- a/R/mDMEA_cell_corr.R +++ b/R/mDMEA_cell_corr.R @@ -12,7 +12,7 @@ mDMEA_cell_corr <- function(drug.sensitivity = "PRISM", gmt = "PRISM", scatter.plot.type = "pearson", FDR.scatter.plots = 0.05, xlab = "Expression Correlation Estimate", ylab = value, position.x = "min", position.y = "min", se = TRUE, - n.dot.sets = 10, ties = FALSE) { + n.dot.sets = 10) { #### Step 1. Load data if necessary #### # get drug.sensitivity, gmt, and expression if PRISM/CCLE if (is.character(drug.sensitivity)) { @@ -108,7 +108,7 @@ mDMEA_cell_corr <- function(drug.sensitivity = "PRISM", gmt = "PRISM", descriptions, min.per.corr, scatter.plots, scatter.plot.type, FDR.scatter.plots, xlab, ylab, - position.x, position.y, se, ties + position.x, position.y, se ) # merge correlation results with drug annotations if !is.null(drug.info) diff --git a/R/mDMEA_gene_corr.R b/R/mDMEA_gene_corr.R old mode 100755 new mode 100644 index 74078b7..2da4053 --- a/R/mDMEA_gene_corr.R +++ b/R/mDMEA_gene_corr.R @@ -1,7 +1,7 @@ mDMEA_gene_corr <- function(gmt = "PRISM", expression = as.list(rep("L1000", length(types))), weights, types, value = "Perturbation", - sample.names = "Drug", + sample.names = colnames(expression[[1]])[1], feature.names = rep("Gene", length(types)), rank.metric = rep("Pearson.est", length(types)), p = 0.05, FDR = 0.25, num.permutations = 1000, stat.type = "Weighted", @@ -12,9 +12,25 @@ mDMEA_gene_corr <- function(gmt = "PRISM", scatter.plot.type = "pearson", FDR.scatter.plots = 0.05, xlab = "Expression", ylab = value, position.x = "min", position.y = "min", se = TRUE, - n.dot.sets = 10, ties = FALSE) { + n.dot.sets = 10) { #### Step 1. Load data if necessary #### - # get gmt and expression if PRISM/L1000 + # get drug.sensitivity, gmt, and expression if PRISM/CCLE + if (is.character(drug.sensitivity)) { + if (drug.sensitivity == "PRISM") { + message("Loading PRISM drug sensitivity AUC scores") + drug.sensitivity <- read.csv(file = paste0( + "https://raw.github.com/BelindaBGarana/", + "DMEA/shiny-app/Inputs/PRISM_drug_mean_AUC_6-23-21.csv" + )) # 481 cell lines + drug.sensitivity$X <- NULL + } else { + stop(paste( + "drug.sensitivity must be either 'PRISM' or data frame per", + "documentation" + )) + } + } + if (is.character(gmt)) { if (gmt == "PRISM") { message("Loading PRISM drug mechanism of action annotations") @@ -29,60 +45,32 @@ mDMEA_gene_corr <- function(gmt = "PRISM", } } - if ("L1000" %in% expression) { - message("Loading L1000") - # source: https://github.com/PNNL-CompBio/coderdata/blob/main/build/lincs/05-LINCS_perturbations.R - # identify URLs - #basename="https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE101406" - L1000 <- 'https://ftp.ncbi.nlm.nih.gov/geo/series/GSE101nnn/GSE101406/suppl/GSE101406%5FBroad%5FLINCS%5FL1000%5FLevel4%5FZSPCINF%5Fmlr12k%5Fn1667x12328.gctx.gz' - L1000.genes <- 'https://ftp.ncbi.nlm.nih.gov/geo/series/GSE101nnn/GSE101406/suppl/GSE101406%5FBroad%5FLINCS%5FL1000%5Fgene%5Finfo.txt.gz' - L1000.inst <- 'https://ftp.ncbi.nlm.nih.gov/geo/series/GSE101nnn/GSE101406/suppl/GSE101406%5FBroad%5FLINCS%5FL1000%5Finst%5Finfo.txt.gz' - - # download source sample & perturbation info - L1000.genes.info <- readr::read_delim(L1000.genes, "\t") # pr_gene_symbol, pr_gene_id - L1000.inst.info <- readr::read_delim(L1000.inst, "\t") # pert_iname; pert_type = "trt_cp" if drug, "ctl_vehicle" if DMSO; cell_id - L1000.inst.info <- L1000.inst.info[L1000.inst.info$pert_type == "trt_cp", ] # only keep drug treatments (remove DMSO controls) - - # download L1000 data - if (file.exists("L1000.gctx")) { - L1000.df <- cmapR::parse_gctx("L1000.gctx") - } else { - res<-download.file(L1000,'L1000.gctx.gz', mode="wb") - L1000.df<-cmapR::parse_gctx(R.utils::gunzip("L1000.gctx.gz")) - } - - # put data into long format - L1000.long <- cmapR::melt_gct(L1000.df) - colnames(L1000.long) <- c("inst_id", "pr_gene_id", "data_value") - L1000.long$pr_gene_id <- as.numeric(L1000.long$pr_gene_id) - - # join with L1000.gene.info based on pr_gene_id; - # L1000.inst.info based on inst_id; - # keep only cell_id, pert_type, pert_iname, gene_symbol, data_value - L1000.full <- L1000.long |> - dplyr::left_join(L1000.genes.info) |> - dplyr::left_join(L1000.inst.info) |> - dplyr::select(cell_id,pert_type,pert_iname,pr_gene_symbol,data_value)|> - dplyr::distinct() - L1000.long <- NULL # save space - - # add relevant columns - L1000.full <- na.omit(L1000.full) - colnames(L1000.full)[1] <- "other_names" # match samples column name - colnames(L1000.full)[4] <- "gene_symbol" # match genes column name - colnames(L1000.full)[3] <- "chem_name" - L1000.full$data_type <- "transcriptomics" - L1000.full$source <- "Broad" - L1000.full$study <- "LINCS" - L1000.full$perturbation_type <- "drug" # all entries have pert_type="trt_cp" + if ("adherent CCLE" %in% expression) { + message("Loading adherent CCLE RNA-seq data version 19Q4") + download.file( + paste0( + "https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/", + "Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin" + ), + destfile = + "Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin" + ) + load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin") - # aggregate across cell types - L1000.full <- reshape2::dcast(L1000.full, gene_symbol ~ chem_name, - value.var = "data_value", fun.aggregate = mean) - colnames(L1000.full)[1] <- feature.names[1] + download.file( + paste0( + "https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/", + "Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin" + ), + destfile = + "Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin" + ) + load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin") - for (i in which(expression == "L1000")) { - expression[[i]] <- L1000.full + RNA.df <- rbind(RNA.first200, RNA.rest) + + for (i in which(expression == "adherent CCLE")) { + expression[[i]] <- RNA.df } } @@ -91,13 +79,28 @@ mDMEA_gene_corr <- function(gmt = "PRISM", stop("Length of types vector must match that of weights list") } + # check that sample names are in drug.sensitivity data frame + if (!(sample.names %in% names(drug.sensitivity))) { + stop(paste("sample.names must match across drug.sensitivity and", + "expression data frames")) + } + + # check that sample names are in expression data frames + for (i in 1:length(types)) { + if (!(sample.names %in% names(expression[[i]]))) { + stop(paste("sample.names must match across drug.sensitivity and", + "expression data frames")) + } + } + #### Step 2. Perform DMEA on each omics type #### DMEA.list <- list() for (i in 1:length(types)) { message(paste("Running DMEA using", types[i], "data")) DMEA.list[[types[i]]] <- panSEA::DMEA_gene_corr( - gmt, expression[[i]], weights[[i]], value, sample.names, + drug.sensitivity, gmt, expression[[i]], + weights[[i]], value, sample.names, feature.names[i], colnames(weights[[i]])[2], rank.metric[i], FDR, num.permutations, stat.type, drug.info, drug, set.type, @@ -105,7 +108,7 @@ mDMEA_gene_corr <- function(gmt = "PRISM", descriptions, min.per.corr, scatter.plots, scatter.plot.type, FDR.scatter.plots, xlab, ylab, - position.x, position.y, se, ties + position.x, position.y, se ) # merge correlation results with drug annotations if !is.null(drug.info) diff --git a/R/mGSEA.R b/R/mGSEA.R old mode 100755 new mode 100644 index f88e045..2343563 --- a/R/mGSEA.R +++ b/R/mGSEA.R @@ -6,7 +6,7 @@ mGSEA <- function(data.list, gmt = as.list(rep( rank.var = rep("Log2FC", length(types)), direction.adjust = NULL, p = 0.05, FDR = 0.25, num.permutations = 1000, stat.type = "Weighted", - min.per.set = 6, n.dot.sets = 10, ties = FALSE) { + min.per.set = 6, n.dot.sets = 10) { #### Step 1. Perform ssGSEA on each omics type #### ssGSEA.list <- list() for (i in 1:length(types)) { @@ -16,7 +16,7 @@ mGSEA <- function(data.list, gmt = as.list(rep( data.list[[i]], gmt[[i]], feature.names[i], rank.var[i], direction.adjust, FDR, - num.permutations, stat.type, min.per.set, ties + num.permutations, stat.type, min.per.set ) } diff --git a/R/netSEA.R b/R/netSEA.R old mode 100755 new mode 100644 diff --git a/R/panSEA.R b/R/panSEA.R old mode 100755 new mode 100644 index dfbdfb6..e7b4565 --- a/R/panSEA.R +++ b/R/panSEA.R @@ -17,7 +17,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)), scatter.plots = TRUE, scatter.plot.type = "pearson", drug.sensitivity = "PRISM", expression = as.list(rep("adherent CCLE", length(types))), - n.network.sets = 2*length(types), n.dot.sets = 10, scale = 5, ties = FALSE) { + n.network.sets = 2*length(types), n.dot.sets = 10, scale = 5) { #### Step 1. Check if formats are correct #### # make sure that there are as many types as other inputs if (length(types) != length(gmt.features) | @@ -77,7 +77,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)), ssGSEA.results <- panSEA::mGSEA(DEGs$all.results, gmt.features, types, feature.names, GSEA.rank.var, p = p, FDR = FDR, num.permutations = num.permutations, stat.type = stat.type, - min.per.set = min.per.set, n.dot.sets = n.dot.sets, ties = ties + min.per.set = min.per.set, n.dot.sets = n.dot.sets ) # compile inputs & results for network graph @@ -110,7 +110,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)), min.per.set = min.per.set, scatter.plots = scatter.plots, scatter.plot.type = scatter.plot.type, - n.dot.sets = n.dot.sets, ties = ties + n.dot.sets = n.dot.sets ) } else if (DMEA.type == "cell_corr") { DMEA.results <- @@ -123,7 +123,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)), min.per.set = min.per.set, scatter.plots = scatter.plots, scatter.plot.type = scatter.plot.type, - n.dot.sets = n.dot.sets, ties = ties + n.dot.sets = n.dot.sets ) } else if (DMEA.type == "gene_corr") { DMEA.results <- @@ -136,7 +136,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)), min.per.set = min.per.set, scatter.plots = scatter.plots, scatter.plot.type = scatter.plot.type, - n.dot.sets = n.dot.sets, ties = ties + n.dot.sets = n.dot.sets ) } @@ -191,7 +191,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)), GSEA.rank.var, p = p, FDR = FDR, num.permutations = num.permutations, stat.type = stat.type, min.per.set = min.per.set, - n.dot.sets = n.dot.sets, ties = ties + n.dot.sets = n.dot.sets ) # compile inputs & outputs for network graph @@ -225,7 +225,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)), min.per.set = min.per.set, scatter.plots = scatter.plots, scatter.plot.type = scatter.plot.type, - n.dot.sets = n.dot.sets, ties = ties + n.dot.sets = n.dot.sets ) } else if (DMEA.type == "cell_corr") { DMEA.results[[colnames(data.list[[1]])[j]]] <- @@ -239,7 +239,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)), min.per.set = min.per.set, scatter.plots = scatter.plots, scatter.plot.type = scatter.plot.type, - n.dot.sets = n.dot.sets, ties = ties + n.dot.sets = n.dot.sets ) } else if (DMEA.type == "gene_corr") { DMEA.results[[colnames(data.list[[1]])[j]]] <- @@ -253,7 +253,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)), min.per.set = min.per.set, scatter.plots = scatter.plots, scatter.plot.type = scatter.plot.type, - n.dot.sets = n.dot.sets, ties = ties + n.dot.sets = n.dot.sets ) } diff --git a/R/ssGSEA.R b/R/ssGSEA.R old mode 100755 new mode 100644 index b7047bd..c57cf2d --- a/R/ssGSEA.R +++ b/R/ssGSEA.R @@ -2,7 +2,7 @@ ssGSEA <- function(data, gmt = "msigdb_Homo sapiens_C2_CP:KEGG", feature.names = colnames(data)[1], rank.var = colnames(data)[2], direction.adjust = NULL, FDR = 0.25, num.permutations = 1000, - stat.type = "Weighted", min.per.set = 6, ties = FALSE) { + stat.type = "Weighted", min.per.set = 6) { # get gmt if not provided if (is.character(gmt)) { if (grepl("msigdb", gmt, ignore.case = TRUE)) { @@ -32,17 +32,14 @@ ssGSEA <- function(data, gmt = "msigdb_Homo sapiens_C2_CP:KEGG", } # run ssGSEA - results <- panSEA::drugSEA_ties( + results <- DMEA::drugSEA( data, gmt, feature.names, rank.var, "gs_name", direction.adjust, FDR, - num.permutations, stat.type, min.per.set, ties = ties + num.permutations, stat.type, min.per.set ) # change "Drug_set" column names to "Feature_set" colnames(results$result)[2] <- "Feature_set" - if (ties) { - colnames(results$result.w.ties)[2] <- "Feature_set" - } colnames(results$removed.sets)[1] <- "Feature_set" colnames(results$removed.sets)[2] <- "N_features" @@ -50,7 +47,7 @@ ssGSEA <- function(data, gmt = "msigdb_Homo sapiens_C2_CP:KEGG", results$replaced.drugs <- NULL # change name of output referring to drugs to features - names(results)[length(results)] <- "unannotated.features" + names(results)[6] <- "unannotated.features" return(results) } diff --git a/README.md b/README.md old mode 100755 new mode 100644 diff --git a/app.R b/app.R new file mode 100644 index 0000000..a9fc4cd --- /dev/null +++ b/app.R @@ -0,0 +1,845 @@ +# Shiny app: multi-omics data analysis +# accepts either 1 or 2 input groups +# if 2 groups, performs differential expression analysis (limma::eBayes) +# also performs enrichment analyses, including drug mechanism enrichment +# analysis for each input data frame + +library(shiny) +library(DT) +library(panSEA) +library(DMEA) +library(data.table) +library(dplyr) +library(ggplot2) +library(msigdbr) +library(visNetwork) + +# set limit for upload file size +MB.limit <- 180 + +# set file names +DEG.files <- c("Differential_expression_results.csv", + "Differential_expression_mean_results.csv", + "Differential_expression_venn_diagram.pdf", + "Differential_expression_correlation_matrix.pdf", + "Differential_expression_dot_plot.pdf") +GSEA.files <- c("GSEA_results.csv", + "GSEA_mean_results.csv", + "GSEA_venn_diagram.pdf", + "GSEA_correlation_matrix.pdf", + "GSEA_dot_plot.pdf", + "GSEA_static_network_graph.pdf", + "GSEA_interactive_network.graph.html") +DMEA.files <- c("DMEA_results.csv", + "DMEA_mean_results.csv", + "DMEA_venn_diagram.pdf", + "DMEA_correlation_matrix.pdf", + "DMEA_dot_plot.pdf", + "DMEA_static_network_graph.pdf", + "DMEA_interactive_network.graph.html") + +# Define UI for application +ui <- fluidPage( + # Application title + titlePanel("panSEA: Multi-omic Set Enrichment Analysis"), + + # Sidebar with a slider input for number of bins + sidebarLayout( + sidebarPanel( + # select 1 or 2 groups + radioButtons("Ngroups", + "How many groups/conditions would you like to analyze?", + choices = list(1, 2), selected = 1 + ), + + # keep track of last selection to add inputs if Ntypes is changed + # source: https://stackoverflow.com/questions/40631788/shiny-observe-triggered-by-dynamicaly-generated-inputs?noredirect=1 + tags$script("$(document).on('change', '.dynamicSI select', function () { + Shiny.onInputChange('lastSelectId',this.id); + Shiny.onInputChange('lastSelect', Math.random()); + });"), + + # select # of input data sets + numericInput("Ntypes", + "How many omics data sets would you like to process?", + value = 2, min = 2 + ), + + # allow input of multiple data sets + uiOutput("omics"), + + # offer advanced settings + checkboxInput(inputId = "advanced", label = "Optional: advanced settings", value = FALSE), + conditionalPanel( + condition = "input.advanced", + textInput("g1Samples", "If 2 groups: columns containing samples belonging to group 1 (e.g., 2:4)"), + textInput("g2Samples", "If 2 groups: columns containing samples belonging to group 2 (e.g., 5:6)"), + selectInput( + "GSEA.rank", "If 2 groups: rank for GSEA", + c("Log2FC", "t"), "Log2FC" + ), + selectInput( + "DMEA.rank", "Rank for DMEA", + c("Pearson.est", "Spearman.est"), "Pearson.est" + ), + numericInput("n.min.per.set", "Minimum features or drugs per set", 6), + numericInput("n.dot.sets", "Number of sets for dot plots", 10), + numericInput("n.net.sets", "Number of sets for network graphs", 10), + sliderInput("p.cutoff", "P-value cutoff", + min = 0, max = 1, value = 0.05 + ), + sliderInput("FDR.cutoff", "False discovery rate cutoff", + min = 0, max = 1, value = 0.25 + ), + selectInput("drugSensType", + "Drug sensitivity data set", + choices = c( + "PRISM (adherent cancer cell lines)" = "prism", + "Other" = "other" + ) + ), + conditionalPanel( + condition = "input.drugSensType == 'other'", + fileInput("drug.sens", + paste0("Upload a CSV file with sample names in column 1 and drug names as the rest of the column names (", MB.limit, " MB limit)"), + accept = ".csv" + ), + fileInput("drug.info", + paste0("Upload a CSV file with a column 'Drug' containing drug names and 'moa' containing set annotations (", MB.limit, " MB limit)"), + accept = ".csv" + ) + ) + ), + + # include "Run" button + actionButton(inputId = "run", label = "Run"), + + # including loading message + conditionalPanel( + condition = "input.run && !output.msg", + textOutput(outputId = "fyi") + ), + + # indicate when run is completed + textOutput("msg") + ), + + # Show a plot of the generated distribution + mainPanel( + # display plots in tabs + tabsetPanel( + tabPanel( + "Gene Set Enrichment Analysis: Dot Plot", plotOutput("GSEA.dot"), + conditionalPanel( + condition = "output.msg=='Run completed'", + downloadButton(outputId = "GSEA.dot.dwnld", + label = "Download dot plot of GSEA results") + ) + ), + tabPanel( + "Drug Mechanism Enrichment Analysis: Dot Plot", + plotOutput("DMEA.dot"), + conditionalPanel( + condition = "output.msg=='Run completed'", + downloadButton(outputId = "DMEA.dot.dwnld", + label = "Download dot plot of DMEA results") + ) + ), + tabPanel( + "Gene Set Enrichment Analysis: Interactive Network Graph", + visNetworkOutput("GSEA.int.net"), + conditionalPanel( + condition = "output.msg=='Run completed'", + downloadButton(outputId = "GSEA.int.net.dwnld", + label = "Download network graph of GSEA results") + ) + ), + tabPanel( + "Drug Mechanism Enrichment Analysis: Interactive Network Graph", + visNetworkOutput("DMEA.int.net"), + conditionalPanel( + condition = "output.msg=='Run completed'", + downloadButton(outputId = "DMEA.int.net.dwnld", + label = "Download network graph of GSEA results") + ) + ), + # tabPanel( + # "Gene Set Enrichment Analysis: Static Network Graph", + # plotOutput("GSEA.net"), + # conditionalPanel( + # condition = "output.msg=='Run completed'", + # downloadButton(outputId = "GSEA.net.dwnld", + # label = "Download network graph of GSEA results") + # ) + # ), + # tabPanel( + # "Drug Mechanism Enrichment Analysis: Static Network Graph", + # plotOutput("DMEA.net"), + # conditionalPanel( + # condition = "output.msg=='Run completed'", + # downloadButton(outputId = "DMEA.net.dwnld", + # label = "Download network graph of GSEA results") + # ) + # ), + tabPanel( + "Gene Set Enrichment Analysis: Averaged Results", + DT::dataTableOutput("GSEAResults"), + conditionalPanel( + condition = "output.msg=='Run completed'", + downloadButton(outputId = "GSEAResults.dwnld", + label = "Download averaged GSEA results") + )), + tabPanel( + "Drug Mechanism Enrichment Analysis: Averaged Results", + DT::dataTableOutput("DMEAResults"), + conditionalPanel( + condition = "output.msg=='Run completed'", + downloadButton(outputId = "DMEAResults.dwnld", + label = "Download averaged DMEA results")) + ) + ), + + # output result files (.zip) + conditionalPanel( + condition = "output.msg=='Run completed'", + downloadButton(outputId = "results", label = "Download all results") + ), + uiOutput("info"), + textOutput("private"), + textOutput("refresh") + ) + ) +) + +# Define backend +server <- function(input, output) { + url <- a("https://github.com/belindabgarana/panSEA", href = "https://github.com/belindabgarana/panSEA") + output$info <- renderUI({ + tagList("Please note that '0' values are < 0.001. For more information or to contact us, please visit: ", url) + }) + output$private <- renderText({ + "No user data is stored on our secure server, so your data will remain private." + }) + output$refresh <- renderText({ + "Please refresh your web browser after each analysis and format your inputs to match the examples on the 'How to Use' page at the URL above to avoid errors. You will also need to refresh this webpage after 5 minutes of inactivity." + }) + output$fyi <- renderText({ + "Running analysis... Please allow 1 to 5 minutes of run time" + }) + options(shiny.maxRequestSize = MB.limit * 1024^2) + + # accept data inputs + output$omics <- renderUI({ + # create list based on Ntypes + buttons <- as.list(1:input$Ntypes) + + # create wellPanel for each input + div( class = "dynamicSI", + lapply(buttons, function(i) { + wellPanel( + helpText(paste0("Input omics data set #",i)), + selectInput(paste0("type",i), + "Omics data type", + choices = c( + "Example (1 group): GSE66539 SKCM sensitive vs. resistant to vemurafenib", + "Example (1 group): GSE31625 NSCLC sensitive vs. resistant to erlotinib", + "Transcriptomics", + "Proteomics", + "Phospho-proteomics", + "Acetyl-proteomics", + "Metabolomics", + "Lipidomics" + ) + ), + fileInput(paste0("data",i), + paste0("Upload a CSV file (", MB.limit, " MB limit)"), + accept = ".csv" + ), + textInput(paste0("featureName",i), + "Column name containing feature names", "Gene"), + selectInput(paste0("gmtType",i), + "Feature set annotations", + choices = c( + "MSigDB (gene sets)", + "Kinase-substrate (substrate_site sets)", + "HMDB (human metabolite sets)", + "Lipid classes", + "Other" + ) + ), + conditionalPanel( + condition = paste0("input.gmtType",i," == 'MSigDB (gene sets)'"), + textInput(paste0("species",i), "Species", "Homo sapiens"), + textInput(paste0("cat",i), "Category (e.g., H, C1, C2, ..., C8)", "C2"), + textInput(paste0("subcat",i), "Optional: sub-category (e.g., CGP, CP:KEGG, or CP:REACTOME for category C2)", "CP:KEGG"), + helpText("More info about MSigDB gene sets is available here: https://www.gsea-msigdb.org/gsea/msigdb/collections.jsp") + ), + conditionalPanel( + condition = paste0("input.gmtType",i," == 'Kinase-substrate (substrate_site sets)'"), + textInput(paste0("species",i), "Species", "human") + ), + conditionalPanel( + condition = paste0("input.gmtType",i," == 'Other'"), + fileInput(paste0("gmtInfo",i), + paste0("Upload a CSV file (", MB.limit, " MB limit)"), + accept = ".csv" + ), + textInput(paste0("feature",i), "Column name containing feature names (e.g., gene_symbol)"), + textInput(paste0("set",i), "Column name containing set names (e.g., gs_name)"), + ), + selectInput(paste0("exprType",i), + "Expression data set to pair with drug sensitivity data", + choices = c( + "Adherent CCLE v19Q4" = "ccle", + "Other" = "other" + ) + ), + conditionalPanel( + condition = paste0("input.exprType",i," == 'other'"), + fileInput(paste0("exprInfo",i), + paste0("Upload a CSV file with sample names in column 1 and feature names as the rest of the column names (", MB.limit, " MB limit)"), + accept = ".csv" + ) + ) + ) + } + ) + ) + }) + + observeEvent(input$run, { + # get input parameters + cat(file = stderr(), "About to get n.groups", "\n") + n.groups <- input$Ngroups + if (n.groups == 1) { + group.names <- "Diseased" + } else { + group.names <- c("Diseased", "Healthy") + } + n.types <- input$Ntypes + GSEA.rank.var <- rep(input$GSEA.rank, n.types) + DMEA.rank.var <- rep(input$DMEA.rank, n.types) + p <- input$p.cutoff + FDR <- input$FDR.cutoff + min.per.set <- input$n.min.per.set + drugSensType <- input$drugSensType + cat(file = stderr(), "About to get drug.sensitivity", "\n") + if (is.character(drugSensType)) { + if (drugSensType == "prism") { + drug.sensitivity <- "PRISM" + } + } else { + drug.sensitivity <- input$drug.sens + } + n.network.sets <- input$n.net.sets + n.dot.plot.sets <- input$n.dot.sets + cat(file = stderr(), "About to get groupSamples", "\n") + if (input$g1Samples != "" & input$g2Samples != "" & + n.groups == 2) { + groupSamples <- list(input$g1Samples, input$g2Samples) + } else if (input$g1Samples != "" & input$g2Samples == "" & + n.groups == 1) { + groupSamples <- list(input$g1Samples) + } else if (input$g2Samples != "" & input$g1Samples == "" & + n.groups == 1) { + groupSamples <- list(input$g2Samples) + } else { + groupSamples <- list(2) + } + cat(file = stderr(), "About to get gmt.drugs", "\n") + if (input$drugSensType == "prism") { + gmt.drugs <- "PRISM" + } else { + gmt.drugs <- DMEA::as_gmt(drug.info, min.per.set = min.per.set) + } + + # get input data + cat(file = stderr(), "About to get input", "\n") + gmt.features <- list() + data.list <- list() + expression <- list() + types <- c() + feature.names <- c() + for (i in 1:n.types){ + # reformat gmt.features + cat(file = stderr(), "About to get info for MSigDB", "\n") + if (input[[paste0("gmtType",i)]] == "MSigDB (gene sets)") { + gmt.features[[i]] <- paste0( + "msigdb_", input[[paste0("species",i)]], "_", + input[[paste0("cat",i)]], "_", input[[paste0("subcat",i)]] + ) + cat(file = stderr(), "About to make ksdb gmt", "\n") + } else if (input[[paste0("gmtType",i)]] == "Kinase-substrate (substrate_site sets)") { + ksdb <- read.csv(paste0("https://raw.githubusercontent.com/", + "BelindaBGarana/panSEA/shiny-app/data/", + "ksdb_20231101.csv")) + ksdb <- ksdb[ksdb$KIN_ORGANISM == input[[paste0("species",i)]], ] + ksdb$SUB_SITE <- paste0(ksdb$SUBSTRATE, ksdb$SUB_MOD_RSD, + collapse = "_") + gmt.features[[i]] <- DMEA::as_gmt(ksdb, "SUB_SITE", "KINASE", + min.per.set = 6, + descriptions = "KIN_ACC_ID") + cat(file = stderr(), "About to make metabolite gmt", "\n") + } else if (input[[paste0("gmtType",i)]] == "HMDB (human metabolite sets)") { + # based on hmdb v5.0 downloaded 20231220: https://hmdb.ca/downloads + hmdb <- read.csv(paste0("https://raw.githubusercontent.com/", + "BelindaBGarana/panSEA/shiny-app/data/", + "ksdb_20231101.csv")) + gmt.features[[i]] <- + DMEA::as_gmt(hmdb, "name", "direct_parent", min.per.set) + cat(file = stderr(), "About to make lipid gmt", "\n") + } else if (input[[paste0("gmtType",i)]] == "Lipid classes") { + # based on lipid MiniOn https://github.com/PNNL-Comp-Mass-Spec/Rodin/blob/master/R/02_lipid_miner.R + # https://pubmed.ncbi.nlm.nih.gov/30977807/ + FattyAcyls<-c("EA", "carnitine","FAHFA", "WE" ) + Prenol<- c("CoQ") + Sterol<- c("Cholesterol","CE") + Sphingolipids<- c("Cer","CerP","HexCer","SM","GM3","GD","PE-Cer","PI-Cer","Sulfatide","GM1","GM2","LacCer","GalCer","GD1", "GD3","GlcCer", "MIP2C","MIPC","GT3") + Glycerophospholipids<-c("PE", "PC", "PS", "PI", "PG", "PA", "CL","PIP","PIP2", "PIP3") + Glycerolipids<- c("TG","DG","MG","DGDG","MGDG","SQMG", "SQDG", "DGTS/A") + lipid.info <- data.frame(FattyAcyls, Prenol, Sterol, Sphingolipids, + Glycerophospholipids, Glycerolipids) + lipid.info <- reshape2::melt(lipid.info, value.name = "lipid") + gmt.features[[i]] <- + DMEA::as_gmt(lipid.info, "lipid", colnames(lipid.info)[1], + min.per.set) + cat(file = stderr(), "About to make custom gmt", "\n") + }else if (input[[paste0("gmtType",i)]] == "Other") { + custom.gmt.features <- read.csv(input[[paste0("gmtInfo",i)]]$datapath) + gmt.features[[i]] <- + DMEA::as_gmt(custom.gmt.features, + input[[paste0("feature",i)]], input[[paste0("set",i)]], + min.per.set) + } + + # read input files + cat(file = stderr(), "About to check for GSE66539 example", "\n") + if (input[[paste0("type",i)]] == "Example (1 group): GSE66539 SKCM sensitive vs. resistant to vemurafenib") { + data.list[[i]] <- read.csv( + paste0("https://raw.githubusercontent.com/BelindaBGarana/DMEA/", + "shiny-app/Examples/Gene_signature/", + "GSE66539_SKCM_sensitive_vs_resistant_to_vemurafenib", + "/Filtered_gene_signature_no_duplicates.csv")) + cat(file = stderr(), "About to check for GSE31625 example", "\n") + } else if (input[[paste0("type",i)]] == "Example (1 group): GSE31625 NSCLC sensitive vs. resistant to erlotinib") { + data.list[[i]] <- read.csv( + paste0("https://raw.githubusercontent.com/BelindaBGarana/DMEA/", + "shiny-app/Examples/Gene_signature/", + "GSE31625_NSCLC_sensitive_vs_resistant_to_erlotinib", + "/Filtered_gene_signature_no_duplicates.csv")) + data.list[[i]][ , 3] <- NULL + cat(file = stderr(), "About to get check for custom input", "\n") + } else { + data.list[[i]] <- read.csv(input[[paste0("data",i)]]$datapath) + } + + # adjust groupSamples if necessary + cat(file = stderr(), "About to adjust groupSamples if necessary", "\n") + if (groupSamples == 2 & n.groups == 2) { + groupSamples <- list(2:(0.5*(ncol(data.list[[1]])+1)), + (0.5*(ncol(data.list[[1]])+1)+1):ncol(data.list[[1]])) + } + cat(file = stderr(), "About to get expression data", "\n") + if (input[[paste0("exprType",i)]] == "ccle") { + expression[[i]] <- "adherent CCLE" + } else { + expression[[i]] <- read.csv(input[[paste0("exprInfo",i)]]$datapath) + } + + # compile other input parameters + types <- c(input[[paste0("type",i)]], types) + feature.names <- c(input[[paste0("featureName",i)]], feature.names) + } + + # run panSEA + cat(file = stderr(), "About to run panSEA", "\n") + results <- panSEA::panSEA( + data.list, types, feature.names, GSEA.rank.var, DMEA.rank.var, + group.names, groupSamples, gmt.features, gmt.drugs, p, FDR, FDR.features, + num.permutations = 1000, stat.type = "Weighted", min.per.set, + scatter.plots = TRUE, scatter.plot.type = "pearson", drug.sensitivity, + expression, n.network.sets, n.dot.plot.sets + ) + + # output results + cat(file = stderr(), "About to output results", "\n") + if (length(group.names) == 2) { + output$results <- downloadHandler( + filename = function() { + paste0("panSEA_results_", Sys.Date(), ".zip") + }, + content = function(file) { + # set file names + all.files <- c("Differential_expression_results.zip", + "GSEA_results.zip", "DMEA_results.zip", + "All_panSEA_results.rds" + ) + + # generate DEG files + write.csv(results$mDEG.results$compiled.results$results, + DEG.files[1], row.names = FALSE) + write.csv(results$mDEG.results$compiled.results$mean.results, + DEG.files[2], row.names = FALSE) + ggplot2::ggsave(DEG.files[3], + results$mDEG.results$compiled.results$venn.diagram, + device = "pdf" + ) + ggplot2::ggsave(DEG.files[4], + results$mDEG.results$compiled.results$corr.matrix, + device = "pdf" + ) + ggplot2::ggsave(DEG.files[5], + results$mDEG.results$compiled.results$dot.plot, + device = "pdf" + ) + zip(zipfile = all.files[1], files = DEG.files) + + + # generate GSEA files + write.csv(results$mGSEA.results$compiled.results$results, + GSEA.files[1], row.names = FALSE) + write.csv(results$mGSEA.results$compiled.results$mean.results, + GSEA.files[2], row.names = FALSE) + ggplot2::ggsave(GSEA.files[3], + results$mGSEA.results$compiled.results$venn.diagram, + device = "pdf" + ) + ggplot2::ggsave(GSEA.files[4], + results$mGSEA.results$compiled.results$corr.matrix, + device = "pdf" + ) + ggplot2::ggsave(GSEA.files[5], + results$mGSEA.results$compiled.results$dot.plot, + device = "pdf" + ) + results$mGSEA.network$static + dev.print(pdf, GSEA.files[6]) + visNetwork::visSave(results$mGSEA.network$interactive, + GSEA.files[7]) + zip(zipfile = all.files[2], files = GSEA.files) + + # generate DMEA files + write.csv(results$mDMEA.results$compiled.results$results, + DMEA.files[1], row.names = FALSE) + write.csv(results$mDMEA.results$compiled.results$mean.results, + DMEA.files[2], row.names = FALSE) + ggplot2::ggsave(DMEA.files[3], + results$mDMEA.results$compiled.results$venn.diagram, + device = "pdf" + ) + ggplot2::ggsave(DMEA.files[4], + results$mDMEA.results$compiled.results$corr.matrix, + device = "pdf" + ) + ggplot2::ggsave(DMEA.files[5], + results$mDMEA.results$compiled.results$dot.plot, + device = "pdf" + ) + results$mDMEA.network$static + dev.print(pdf, DMEA.files[6]) + visNetwork::visSave(results$mDMEA.network$interactive, + DMEA.files[7]) + zip(zipfile = all.files[3], files = DMEA.files) + + # save all results + saveRDS(results, all.files[4]) + zip(zipfile = file, files = all.files) + } + ) + + output$GSEA.dot.dwnld <- downloadHandler( + filename = function() { + paste0("GSEA_dot_plot_", Sys.Date(), ".pdf") + }, + content = function(file) { + ggplot2::ggsave(file, results$mGSEA.results$compiled.results$dot.plot, + device = "pdf") + } + ) + output$GSEA.dot <- + renderPlot({ + results$mGSEA.results$compiled.results$dot.plot + }) + + output$DMEA.dot.dwnld <- downloadHandler( + filename = function() { + paste0("DMEA_dot_plot_", Sys.Date(), ".pdf") + }, + content = function(file) { + ggplot2::ggsave(file, results$mDMEA.results$compiled.results$dot.plot, + device = "pdf") + } + ) + output$DMEA.dot <- + renderPlot({ + results$mDMEA.results$compiled.results$dot.plot + }) + + output$GSEA.int.net.dwnld <- downloadHandler( + filename = function() { + paste0("GSEA_interactive_network_graph_", Sys.Date(), ".html") + }, + content = function(file) { + visSave(results$mGSEA.network$interactive, file) + } + ) + output$GSEA.int.net <- + renderVisNetwork({ + results$mGSEA.network$interactive + }) + + output$DMEA.int.net.dwnld <- downloadHandler( + filename = function() { + paste0("DMEA_interactive_network_graph_", Sys.Date(), ".html") + }, + content = function(file) { + visSave(results$mDMEA.network$interactive, file) + } + ) + output$DMEA.int.net <- + renderVisNetwork({ + results$mDMEA.network$interactive + }) + + + # output$GSEA.net.dwnld <- downloadHandler( + # filename = function() { + # paste0("GSEA_static_network_graph_", Sys.Date(), ".pdf") + # }, + # content = function(file) { + # results$mGSEA.network$static + # dev.print(pdf, file) + # } + # ) + # output$GSEA.net <- + # renderPlot({ + # results$mGSEA.network$static + # }) + # + # output$DMEA.net.dwnld <- downloadHandler( + # filename = function() { + # paste0("DMEA_static_network_graph_", Sys.Date(), ".pdf") + # }, + # content = function(file) { + # results$mDMEA.network + # dev.print(pdf, file) + # } + # ) + # output$DMEA.net <- + # renderPlot({ + # results$mDMEA.network + # }) + + output$GSEAResults.dwnld <- downloadHandler( + filename = function() { + paste0("GSEA_mean_results_", Sys.Date(), ".csv") + }, + content = function(file) { + write.csv(results$mGSEA.results$compiled.results$mean.results, file) + } + ) + GSEA.results <- results$mGSEA.results$compiled.results$mean.results %>% + dplyr::mutate_if(is.numeric, ~round(., 3)) + output$GSEAResults <- DT::renderDataTable({ + DT::datatable(GSEA.results + # , + # options = list(order = list(list(2, 'desc'))) + ) + }) + + output$DMEAResults.dwnld <- downloadHandler( + filename = function() { + paste0("DMEA_mean_results_", Sys.Date(), ".csv") + }, + content = function(file) { + write.csv(results$mDMEA.results$compiled.results$mean.results, file) + } + ) + DMEA.results <- results$mDMEA.results$compiled.results$mean.results %>% + dplyr::mutate_if(is.numeric, ~round(., 3)) + output$DMEAResults <- DT::renderDataTable({ + DT::datatable(DMEA.results + # , + # options = list(order = list(list(2, 'desc'))) + ) + }) + + output$msg <- renderText({ + "Run completed" + }) + } else if (n.groups == 1) { + output$results <- downloadHandler( + filename = function() { + paste0("panSEA_results_", Sys.Date(), ".zip") + }, + content = function(file) { + # set file names + all.files <- c("GSEA_results.zip", "DMEA_results.zip", + "All_panSEA_results.rds" + ) + + # generate GSEA files + write.csv(results$mGSEA.results[[1]]$compiled.results$results, + GSEA.files[1], row.names = FALSE) + write.csv(results$mGSEA.results[[1]]$compiled.results$mean.results, + GSEA.files[2], row.names = FALSE) + ggplot2::ggsave(GSEA.files[3], + results$mGSEA.results[[1]]$compiled.results$venn.diagram, + device = "pdf" + ) + ggplot2::ggsave(GSEA.files[4], + results$mGSEA.results[[1]]$compiled.results$corr.matrix, + device = "pdf" + ) + ggplot2::ggsave(GSEA.files[5], + results$mGSEA.results[[1]]$compiled.results$dot.plot, + device = "pdf" + ) + results$mGSEA.network[[1]]$static + dev.print(pdf, GSEA.files[6]) + visNetwork::visSave(results$mGSEA.network[[1]]$interactive, + GSEA.files[7]) + zip(zipfile = all.files[2], files = GSEA.files) + + # generate DMEA files + write.csv(results$mDMEA.results[[1]]$compiled.results$results, + DMEA.files[1], row.names = FALSE) + write.csv(results$mDMEA.results[[1]]$compiled.results$mean.results, + DMEA.files[2], row.names = FALSE) + ggplot2::ggsave(DMEA.files[3], + results$mDMEA.results[[1]]$compiled.results$venn.diagram, + device = "pdf" + ) + ggplot2::ggsave(DMEA.files[4], + results$mDMEA.results[[1]]$compiled.results$corr.matrix, + device = "pdf" + ) + ggplot2::ggsave(DMEA.files[5], + results$mDMEA.results[[1]]$compiled.results$dot.plot, + device = "pdf" + ) + results$mDMEA.network[[1]]$static + dev.print(pdf, DMEA.files[6]) + visNetwork::visSave(results$mDMEA.network[[1]]$interactive, + DMEA.files[7]) + zip(zipfile = all.files[3], files = DMEA.files) + + # save all results + saveRDS(results, all.files[4]) + zip(zipfile = file, files = all.files) + } + ) + + output$GSEA.dot.dwnld <- downloadHandler( + filename = function() { + paste0("GSEA_dot_plot_", Sys.Date(), ".pdf") + }, + content = function(file) { + ggplot2::ggsave(file, results$mGSEA.results[[1]]$compiled.results$dot.plot, + device = "pdf") + } + ) + output$GSEA.dot <- + renderPlot({ + results$mGSEA.results[[1]]$compiled.results$dot.plot + }) + + output$DMEA.dot.dwnld <- downloadHandler( + filename = function() { + paste0("DMEA_dot_plot_", Sys.Date(), ".pdf") + }, + content = function(file) { + ggplot2::ggsave(file, results$mDMEA.results[[1]]$compiled.results$dot.plot, + device = "pdf") + } + ) + output$DMEA.dot <- + renderPlot({ + results$mDMEA.results[[1]]$compiled.results$dot.plot + }) + + output$GSEA.int.net.dwnld <- downloadHandler( + filename = function() { + paste0("GSEA_interactive_network_graph_", Sys.Date(), ".html") + }, + content = function(file) { + visSave(results$mGSEA.network[[1]]$interactive, file) + } + ) + output$GSEA.int.net <- + renderVisNetwork({ + results$mGSEA.network[[1]]$interactive + }) + + output$DMEA.int.net.dwnld <- downloadHandler( + filename = function() { + paste0("DMEA_interactive_network_graph_", Sys.Date(), ".html") + }, + content = function(file) { + visSave(results$mDMEA.network[[1]]$interactive, file) + } + ) + output$DMEA.int.net <- + renderVisNetwork({ + results$mDMEA.network[[1]]$interactive + }) + + # output$GSEA.net.dwnld <- downloadHandler( + # filename = function() { + # paste0("GSEA_static_network_graph_", Sys.Date(), ".pdf") + # }, + # content = function(file) { + # results$mGSEA.network[[1]]$static + # dev.print(pdf, file) + # } + # ) + # output$GSEA.net <- + # renderPlot({ + # results$mGSEA.network[[1]]$static + # }) + + output$GSEAResults.dwnld <- downloadHandler( + filename = function() { + paste0("GSEA_mean_results_", Sys.Date(), ".csv") + }, + content = function(file) { + write.csv(results$mGSEA.results[[1]]$compiled.results$mean.results, + file) + } + ) + GSEA.results <- results$mGSEA.results[[1]]$compiled.results$mean.results %>% + dplyr::mutate_if(is.numeric, ~round(., 3)) + output$GSEAResults <- DT::renderDataTable({ + DT::datatable(GSEA.results + # , + # options = list(order = list(list(2, 'desc'))) + ) + }) + + output$DMEAResults.dwnld <- downloadHandler( + filename = function() { + paste0("DMEA_mean_results_", Sys.Date(), ".csv") + }, + content = function(file) { + write.csv(results$mDMEA.results[[1]]$compiled.results$mean.results, + file) + } + ) + DMEA.results <- results$mDMEA.results[[1]]$compiled.results$mean.results %>% + dplyr::mutate_if(is.numeric, ~round(., 3)) + output$DMEAResults <- DT::renderDataTable({ + DT::datatable(DMEA.results + # , + # options = list(order = list(list(2, 'desc'))) + ) + }) + + output$msg <- renderText({ + "Run completed" + }) + } + }) +} + +# Run the application +shinyApp(ui = ui, server = server) diff --git a/data/gmt_ksdb_human.rds b/data/gmt_ksdb_human.rds old mode 100755 new mode 100644 diff --git a/data/ksdb_20231101.csv b/data/ksdb_20231101.csv old mode 100755 new mode 100644 diff --git a/man/.DS_Store b/man/.DS_Store new file mode 100644 index 0000000000000000000000000000000000000000..9df81b11d9781d3b2e4b2c9c63cc3f9b95821a8c GIT binary patch literal 6148 zcmeHKy-ve05WXvwXhDL)#DbK8iJ=m2kXEg#4lMKm3jI+*3bbm=z?PlIfDwrY;|ZAH zyR(Iyw5d8Fgzh5yb8LTS-xnv2iHMtzqYI)M5mk@`%X`Syn6yh;v68Pj0J8d6(2}M! zr>AbR(%ULb0aM_wDIo7|mFjdww{%Cr`#T*DlIZ}g@@Z%w)xXqGB08iY-t&8!fs@df z`Y5-kO&#?#>LwZXdyZXO%f1A^v5wEDTkt#7E95`t_(zzl8?BF-j1fVC2qdC8F3}<% z0pjQLApX$91Rfq#gH0Y@;o&Usu)9ey{>;s|qP+_hDot|zkAwbO#>gM=@e<51>tm}Z zOR`=Zb#l9sz)5RI8yZKMcZ&JjNbVhiHMZqXHe3{Skv5 z9rcm#7kf+{Iy$kA3_pHk_9qn9(NQ01cjDNg<)(lskX2yE-PUCPZx^5cvn0DS1x$f| zr2v;(y;c(;`Mq@|IN56>q-!KG>6bcG3NpVPYeBZ+6C^dXMN$C99#e;?f!U9M%3zr( I@T&@Z12z!YI{*Lx literal 0 HcmV?d00001 diff --git a/man/DMEA_cell_corr.Rd b/man/DMEA_cell_corr.Rd old mode 100755 new mode 100644 index 2f114a7..d331773 --- a/man/DMEA_cell_corr.Rd +++ b/man/DMEA_cell_corr.Rd @@ -20,7 +20,7 @@ DMEA_cell_corr(drug.sensitivity, gmt=NULL, expression, weights, value="AUC", exclusions=c("-666", "NA", "na", "NaN", "NULL"), descriptions=NULL, min.per.corr=3, scatter.plots=TRUE, scatter.plot.type="pearson", FDR.scatter.plots=0.05, xlab="Expression Correlation Estimate", ylab=value, - position.x="min", position.y="min", se=TRUE, ties=FALSE) + position.x="min", position.y="min", se=TRUE) } \arguments{ @@ -138,13 +138,10 @@ DMEA_cell_corr(drug.sensitivity, gmt=NULL, expression, weights, value="AUC", Must be "min", "mid", "max", or numeric. Default: "max". } - \item{se}{Logical operator describing whether or not to include the 95 - percent confidence interval limits of the regression line on the scatter - plots. Default: TRUE. - } - - \item{ties}{Logical operator describing whether or not to permute order of drugs with tied ranks. Default: FALSE. - } + \item{se}{Logical operator describing whether or not to include the 95 + percent confidence interval limits of the regression line on the scatter + plots. Default: TRUE. + } } \value{ diff --git a/man/DMEA_gene_corr.Rd b/man/DMEA_gene_corr.Rd old mode 100755 new mode 100644 index dbebaeb..693335c --- a/man/DMEA_gene_corr.Rd +++ b/man/DMEA_gene_corr.Rd @@ -19,7 +19,7 @@ DMEA_gene_corr(gmt=NULL, expression, weights, value="Perturbation", exclusions=c("-666", "NA", "na", "NaN", "NULL"), descriptions=NULL, min.per.corr=3, scatter.plots=TRUE, scatter.plot.type="pearson", FDR.scatter.plots=0.05, xlab="Expression", ylab=value, - position.x="min", position.y="min", se=TRUE, ties=FALSE) + position.x="min", position.y="min", se=TRUE) } \arguments{ @@ -132,13 +132,10 @@ DMEA_gene_corr(gmt=NULL, expression, weights, value="Perturbation", Must be "min", "mid", "max", or numeric. Default: "max". } - \item{se}{Logical operator describing whether or not to include the 95 - percent confidence interval limits of the regression line on the scatter - plots. Default: TRUE. - } - - \item{ties}{Logical operator describing whether or not to permute order of drugs with tied ranks. Default: FALSE. - } + \item{se}{Logical operator describing whether or not to include the 95 + percent confidence interval limits of the regression line on the scatter + plots. Default: TRUE. + } } \value{ diff --git a/man/WV.Rd b/man/WV.Rd deleted file mode 100755 index 3a7b66b..0000000 --- a/man/WV.Rd +++ /dev/null @@ -1,97 +0,0 @@ -\name{WV} - -\alias{WV} - -\title{Weighted Voting -} - -\description{Weights are multiplied by their expression values, then summed -across all parameters (e.g., genes) for each sample or cell line to produce a -score. Various types of expression data may be used (e.g., RNAseq, proteomics -data). -} - -\usage{ -WV(expression, weights, sample.names=colnames(expression)[1], - gene.names=colnames(weights)[1], weight.values=colnames(weights)[2]) -} - -\arguments{ - \item{expression}{Data frame containing normalized gene expression with gene - symbols as column names, except for one column which contains sample names. - } - - \item{weights}{Data frame with gene.names and weight.values (e.g., - log2(fold-change) values). All gene.names must be present in the expression - data frame. - } - - \item{sample.names}{Column name in expression data frame containing the sample - names. Default: colnames(expression)[1]. - } - - \item{gene.names}{Column name in weights data frame containing the gene - symbols. Default: colnames(weights)[1]. - } - - \item{weight.values}{Column name in weights data frame containing the weight - values (e.g., log2(fold-change) values). Default: colnames(weights)[2]. - } -} - -\value{ - \item{scores}{Data frame with Weighted Voting scores for each sample name.} - - \item{unused.weights}{Data frame with input weights not used for Weighted - Voting.} -} - -\references{ -Garana, B.B., Joly, J.H., Delfarah, A. et al. Drug mechanism enrichment analysis -improves prioritization of therapeutics for repurposing. BMC Bioinformatics 24, -215 (2023). https://doi.org/10.1186/s12859-023-05343-8 -} - -\author{Belinda B. Garana -} - -\section{Warning}{Make sure your weights have the same gene names as your -expression data frame, and that your expression data frame is formatted with gene -symbols along columns.} - -\examples{ -## Step 1: prepare gene weight data frame -# create list of gene symbols -Gene <- paste0("Gene_", seq(from = 1, to = 50)) - -# by default, gene symbols are found in -# the first column of your weights data frame -weights <- as.data.frame(Gene) - -# give each gene a weight -# by default, gene weight values are found in -# the second column of your weights data frame -weights$Rank_metric <- rnorm(length(Gene)) - -## Step 2: prepare expression data frame -# by default, column 1 of your expression data frame is -# the column name from which sample names are gathered and -# the column containing sample names in your drug sensitivity -# data frame should have the same name - -# create list of sample names -Sample_ID <- seq(from = 1, to = 21) - -# by default, column 1 of your expression data frame is -# the column name from which sample names are gathered -expression <- as.data.frame(Sample_ID) - -# give each gene values representative of normalized RNA expression -# each gene is represented by a column in your expression data frame -for(i in 1:length(Gene)){ - expression[,c(Gene[i])] <- rnorm(length(Sample_ID), sd = 0.5) -} - -## Step 3: run Weighted Voting to score each sample -WV.test <- panSEA::WV(expression, weights) -} diff --git a/man/compile_mDEG.Rd b/man/compile_mDEG.Rd old mode 100755 new mode 100644 diff --git a/man/compile_mDMEA.Rd b/man/compile_mDMEA.Rd old mode 100755 new mode 100644 diff --git a/man/compile_mGSEA.Rd b/man/compile_mGSEA.Rd old mode 100755 new mode 100644 diff --git a/man/drugSEA_ties.Rd b/man/drugSEA_ties.Rd deleted file mode 100755 index 63c5506..0000000 --- a/man/drugSEA_ties.Rd +++ /dev/null @@ -1,157 +0,0 @@ -\name{drugSEA_ties} - -\alias{drugSEA_ties} - -\title{Drug Set Enrichment Analysis with Ties -} - -\description{Using drug rank metrics and drug set annotations, drugSEA -calculates the enrichment of drug sets allowing for the consideration of ties. -It can also produce plots and generate a gmt object for future enrichment analyses. -} - -\usage{ -drugSEA_ties(data, gmt=NULL, drug="Drug", rank.metric="Pearson.est", - set.type="moa", direction.adjust=NULL, FDR=0.25, - num.permutations=1000, stat.type="Weighted", min.per.set=6, - sep = "[|]", exclusions = c("-666", "NA", "na", "NaN", "NULL"), - descriptions=NULL, convert.synonyms=FALSE, ties=FALSE) -} - -\arguments{ - \item{data}{Data frame containing rank metric for each drug. - } - - \item{gmt}{Optional: gmt object containing drug sets (e.g., output from - GSA.read.gmt function from GSA package). If gmt is not provided, set.type - parameter must match a column name in data. Default: NULL. - } - - \item{drug}{Column name in data containing the drug names. Default: "Drug". - } - - \item{rank.metric}{Column name in data containing the metric for ranking - drugs. Default: "Pearson.est". - } - - \item{set.type}{Column name in data containing the set membership information - for each drug. Optional unless using direction.adjust feature or gmt is not - provided. Default: "moa". - } - - \item{direction.adjust}{Vector of conditions for set.type to identify which, - if any, estimates to multiply by -1 (e.g., c(" agonist", " activator")). - Default: NULL. - } - - \item{FDR}{False discovery rate cut-off value to produce mountain plots for - significant enrichments. Default: 0.05. - } - - \item{num.permutations}{Number of permutations to perform. Default: 1000. - } - - \item{stat.type}{Kolmogorov-Smirnov statistic type. Must be either "Weighted" - (weight = 1) or "Classic" (weight = 0). Default: "Weighted". - } - - \item{min.per.set}{The minimum number of drugs required per set. Default: 6. - } - - \item{sep}{Character(s) to use for splitting drug set names. Optional unless - gmt is not provided. Default: "[|]". - } - - \item{exclusions}{A vector of drug set names to be excluded from the - generated gmt. Optional unless gmt is not provided. Default: c("-666", "NA", - "na", "NaN", "NULL"). - } - - \item{descriptions}{Optional: column name in data containing descriptions for - each drug set. If not provided and gmt is also not provided, set.type will be - used for the descriptions instead. Default: NULL. - } - - \item{convert.synonyms}{Logical operator describing whether or not to convert - unannotated drug names to synonyms for drugs in the PRISM database. Default: - FALSE. - } - - \item{ties}{Logical operator describing whether or not to shuffle the order of - input drugs with tied rank values. Default: FALSE. - } -} - -\value{ - \item{gmt }{gmt object containing list of elements (genesets), set names - (geneset.names), and set descriptions (geneset.descriptions).} - - \item{result }{Data frame containing enrichment analysis results for drug - sets. If ties, these results are shuffled to account for any tied drugs in input.} - - \item{result.w.ties }{Data frame containing enrichment analysis results - using original input order.} - - \item{mtn.plots }{ggplot object list of mountain plots for drug sets with - enrichments which meet the FDR threshold.} - - \item{volcano.plot }{ggplot object for volcano plot summarizing enrichment - of all drug sets evaluated.} - - \item{removed.sets }{Data frame containing any drug sets which had too few - elements to be evaluated and their number of elements.} - - \item{replaced.drugs }{Data frame containing input drug names which were - replaced based on PubChem synonyms and their PubChem CID.} - - \item{unannotated.drugs }{Data frame containing input drug names which were - not matched to a drug set and their ranks.} -} - -\references{ -Garana, B.B., Joly, J.H., Delfarah, A. et al. Drug mechanism enrichment analysis -improves prioritization of therapeutics for repurposing. BMC Bioinformatics 24, -215 (2023). https://doi.org/10.1186/s12859-023-05343-8 -} - -\author{Belinda B. Garana, James H. Joly -} - -\note{Mountain plots can be saved individually using: -for(i in seq_len(length(drugSEA.output$mtn.plots))){ -ggsave(filename, drugSEA.output$mtn.plots[[i]]) -} - -Output gmt can be saved for future use as an R object using: -saveRDS(DMEA.output$gmt, file) -} - -\section{Warning}{Each drug must have 1 non-zero, numeric rank.metric value to -be included in the analysis. NA and zero values will be omitted after coercing -the rank.metric values to be of type "numeric". If no gmt is provided, then -set.type must be provided in the input data. Either the gmt or set.type column -must provide annotations for 2+ drug sets. - -If convert.synonyms=TRUE, an internet connection is required and the drug -synonym conversion is fastest if the input drug names are PubChem CIDs. -} - -\examples{ -## Step 1: prepare data frame containing rank metrics -## and set annotations for each drug -# Drug is our default name for the column containing drug names -Drug <- paste0("Drug_", seq(from = 1, to = 24)) - -data <- as.data.frame(Drug) - -# Pearson.est is our default name for the column containing drug ranks -data$Pearson.est <- rnorm(length(Drug), sd = 0.25) - -# moa is our default name for the column containing drug set annotations -data$moa <- rep(paste("Set", LETTERS[seq(from = 1, to = 4)]), 6) - -## Step 2: perform drugSEA and store results -# if you use other column names for your data parameter, -# then make sure to set drug, rank.metric, and set.type parameters -drugSEA.test <- panSEA::drugSEA_ties(data) -} diff --git a/man/mDEG.Rd b/man/mDEG.Rd old mode 100755 new mode 100644 index b4ac681..6d6cc95 --- a/man/mDEG.Rd +++ b/man/mDEG.Rd @@ -11,22 +11,48 @@ transformation is performed prior to analysis. } \usage{ -mDEG(data.list, factor.info, feature.names = rep("Gene", length(data.list)), +mDEG(data.list, types, group.names=c("Diseased", "Healthy"), + group.samples=list(2:(0.5 * (ncol(data.list[[1]]) + 1)), + (0.5 * (ncol(data.list[[1]]) + 1) + 1):ncol(data.list[[1]])), + group.names2=NULL, group.samples2=NULL, + feature.names=rep("Gene", length(types)), p=0.05, FDR.features=0.05, n.dot.features=10) } \arguments{ \item{data.list}{List of data frames where each data frame has one column containing feature names (e.g., gene symbols) and the rest of its columns - having sample names as column names. List names will be interpreted as - omics types (e.g., "global" or "phospho"). Non-numeric column will be - assumed to be feature names (e.g., "Gene" or "SUB_SITE"). + having sample names as column names. } - \item{factor.info}{Data frame where rownames are sample names found in each - data frame of data.list, the first column is a contrast with 2 levels, and - optionally there may be a second column to be included in the design matrix - (e.g., sex or batch effect).} + \item{types}{Vector of character descriptions of each omics type (e.g., + c("Transcriptomics", "Proteomics")). + } + + \item{group.names}{Vector of names for 2 sample groups. + Default: c("Diseased", "Healthy"). + } + + \item{group.samples}{List of column numbers or names corresponding to the + group names. For example, if columns 2:4 correspond to the first group (e.g., + "Diseased") and columns 5:7 correspond to the second group (e.g., "Healthy"), + then group.samples would be list(2:4, 5:7). The order of samples must be the + same across all data frames in the input data.list. Default: + list(2:(0.5 * (ncol(data.list[[1]]) + 1)), + (0.5 * (ncol(data.list[[1]]) + 1) + 1):ncol(data.list[[1]])). + } + + \item{group.names2}{Optional: vector of names for 2 sample groups intended + for batch effects or other confounding factors (e.g., sex). Default: NULL. + } + + \item{group.samples2}{Optional: list of column numbers or names corresponding + to group.names2. For example, if columns 2:4 correspond to the first group + (e.g., "Batch1") and columns 5:7 correspond to the second group + (e.g., "Batch2"), then group.samples2 would be list(2:4, 5:7). The order of + samples must be the same across all data frames in the input data.list. + Default: NULL. + } \item{feature.names}{Vector of column names containing feature names (e.g., gene symbols) in each corresponding data frame in the input data.list. @@ -90,13 +116,9 @@ expr <- data.frame(Gene, Sample_1, Sample_2, Sample_3, expr2 <- data.frame(Gene, Sample_1, Sample_2, Sample_3, Sample_4, Sample_5, Sample_6) -# compile expression data into list with descriptive names -data.list <- list("Transcriptomics" = expr, "Proteomics" = expr2) - -# prepare factor info for differential expression contrast -factor.info <- data.frame("contrast" = c(rep(0, 3), rep(1, 3))) -rownames(factor.info) <- colnames(expr)[2:ncol(expr)] - ## Step 3: perform differential expression analysis -mDEG.test <- panSEA::mDEG(data.list, factor.info) +# by default, we assume the first half of samples (1-3) are "Diseased" +# and the second half of samples (4-6) are "Healthy" +mDEG.test <- panSEA::mDEG(list(expr, expr2), + types = c("Transcriptomics", "Proteomics")) } diff --git a/man/mDMEA.Rd b/man/mDMEA.Rd old mode 100755 new mode 100644 index 716c288..4267d33 --- a/man/mDMEA.Rd +++ b/man/mDMEA.Rd @@ -24,7 +24,7 @@ mDMEA(drug.sensitivity="PRISM", gmt="PRISM", descriptions=NULL, min.per.corr=3, scatter.plots=TRUE, scatter.plot.type="pearson", FDR.scatter.plots=0.05, xlab="Weighted Voting Score", ylab=value, position.x="min", - position.y="min", se=TRUE, n.dot.sets=10, ties=FALSE) + position.y="min", se=TRUE, n.dot.sets=10) } \arguments{ @@ -164,9 +164,6 @@ mDMEA(drug.sensitivity="PRISM", gmt="PRISM", in the dot plot. The top significant sets will be selected based on abs(mean_NES) and p & FDR cutoff values. Default: 10. } - - \item{ties}{Logical operator describing whether or not to permute order of drugs with tied ranks. Default: FALSE. - } } \value{ diff --git a/man/mDMEA_cell_corr.Rd b/man/mDMEA_cell_corr.Rd old mode 100755 new mode 100644 index 225f04a..2c674d7 --- a/man/mDMEA_cell_corr.Rd +++ b/man/mDMEA_cell_corr.Rd @@ -23,7 +23,7 @@ mDMEA_cell_corr(drug.sensitivity="PRISM", gmt="PRISM", descriptions=NULL, min.per.corr=3, scatter.plots=TRUE, scatter.plot.type="pearson", FDR.scatter.plots=0.05, xlab="Expression Correlation Estimate", ylab=value, position.x="min", - position.y="min", se=TRUE, n.dot.sets=10, ties=FALSE) + position.y="min", se=TRUE, n.dot.sets=10) } \arguments{ @@ -159,9 +159,6 @@ mDMEA_cell_corr(drug.sensitivity="PRISM", gmt="PRISM", in the dot plot. The top significant sets will be selected based on abs(mean_NES) and p & FDR cutoff values. Default: 10. } - - \item{ties}{Logical operator describing whether or not to permute order of drugs with tied ranks. Default: FALSE. - } } \value{ diff --git a/man/mDMEA_gene_corr.Rd b/man/mDMEA_gene_corr.Rd old mode 100755 new mode 100644 index 95ceb56..4aaf5cd --- a/man/mDMEA_gene_corr.Rd +++ b/man/mDMEA_gene_corr.Rd @@ -22,7 +22,7 @@ mDMEA_gene_corr(gmt="PRISM", descriptions=NULL, min.per.corr=3, scatter.plots=TRUE, scatter.plot.type="pearson", FDR.scatter.plots=0.05, xlab="Expression", ylab=value, position.x="min", - position.y="min", se=TRUE, n.dot.sets=10, ties=FALSE) + position.y="min", se=TRUE, n.dot.sets=10) } \arguments{ @@ -152,9 +152,6 @@ mDMEA_gene_corr(gmt="PRISM", in the dot plot. The top significant sets will be selected based on abs(mean_NES) and p & FDR cutoff values. Default: 10. } - - \item{ties}{Logical operator describing whether or not to permute order of drugs with tied ranks. Default: FALSE. - } } \value{ diff --git a/man/mGSEA.Rd b/man/mGSEA.Rd old mode 100755 new mode 100644 index 1886126..6c36a4c --- a/man/mGSEA.Rd +++ b/man/mGSEA.Rd @@ -13,7 +13,7 @@ mGSEA(data.list, gmt=as.list(rep("msigdb_Homo sapiens_C2_CP:KEGG", length(types) types, feature.names=rep("Gene", length(types)), rank.var=rep("Log2FC", length(types)), direction.adjust=NULL, p=0.05, FDR=0.25, num.permutations=1000, stat.type="Weighted", min.per.set=6, - n.dot.sets=10, ties=FALSE) + n.dot.sets=10) } \arguments{ @@ -70,9 +70,6 @@ mGSEA(data.list, gmt=as.list(rep("msigdb_Homo sapiens_C2_CP:KEGG", length(types) in the dot plot. The top significant sets will be selected based on abs(mean_NES) and p & FDR cutoff values. Default: 10. } - - \item{ties}{Logical operator describing whether or not to permute order of genes with tied ranks. Default: FALSE. - } } \value{ diff --git a/man/netSEA.Rd b/man/netSEA.Rd old mode 100755 new mode 100644 diff --git a/man/panSEA.Rd b/man/panSEA.Rd old mode 100755 new mode 100644 index 93b09e7..b3e6949 --- a/man/panSEA.Rd +++ b/man/panSEA.Rd @@ -22,7 +22,7 @@ panSEA(data.list, types, feature.names = rep("Gene", length(types)), gmt.drugs="PRISM", GSEA=TRUE, DMEA=TRUE, DMEA.type="WV", p=0.05, FDR=0.25, FDR.features=0.05, min.per.set=6, drug.sensitivity="PRISM", expression=as.list(rep("adherent CCLE", length(types))), - n.network.sets=2*length(types), n.dot.sets=10, scale=5, ties=FALSE) + n.network.sets=2*length(types), n.dot.sets=10, scale=5) } \arguments{ @@ -164,9 +164,6 @@ panSEA(data.list, types, feature.names = rep("Gene", length(types)), \item{scale}{Numeric value to multiply by rank.var value to size vertices on network graphs for visibility. Default: 5. } - - \item{ties}{Logical operator describing whether or not to permute order of genes with tied ranks. Default: FALSE. - } } \value{ diff --git a/man/ssGSEA.Rd b/man/ssGSEA.Rd old mode 100755 new mode 100644 index aa7a613..1dedbf7 --- a/man/ssGSEA.Rd +++ b/man/ssGSEA.Rd @@ -10,7 +10,7 @@ \usage{ ssGSEA(data, gmt="msigdb_Homo sapiens_C2_CP:KEGG", direction.adjust=NULL, -FDR=0.25, num.permutations=1000, stat.type="Weighted", min.per.set=6, ties=FALSE) +FDR=0.25, num.permutations=1000, stat.type="Weighted", min.per.set=6) } \arguments{ @@ -48,9 +48,6 @@ FDR=0.25, num.permutations=1000, stat.type="Weighted", min.per.set=6, ties=FALSE \item{min.per.set}{The minimum number of drugs required per set. Default: 6. } - - \item{ties}{Logical operator describing whether or not to permute order of genes with tied ranks. Default: FALSE. - } } \value{ diff --git a/panSEA.Rproj b/panSEA.Rproj old mode 100755 new mode 100644 index eaa6b81..21a4da0 --- a/panSEA.Rproj +++ b/panSEA.Rproj @@ -15,4 +15,3 @@ LaTeX: pdfLaTeX BuildType: Package PackageUseDevtools: Yes PackageInstallArgs: --no-multiarch --with-keep.source -PackageRoxygenize: rd,collate,namespace diff --git a/vignettes/panSEA.Rmd b/vignettes/panSEA.Rmd old mode 100755 new mode 100644 index fd483ab..519865c --- a/vignettes/panSEA.Rmd +++ b/vignettes/panSEA.Rmd @@ -26,6 +26,9 @@ data which corresponds to the input omics data type or use the default CCLE RNA-seq data (version 19Q4) and PRISM drug screen of 327 adherent cancer cell lines. +# Citation +To cite this package, please use: +Garana, B.B., Joly, J.H., Delfarah, A. et al. Drug mechanism enrichment analysis improves prioritization of therapeutics for repurposing. BMC Bioinformatics 24, 215 (2023). https://doi.org/10.1186/s12859-023-05343-8 # Installation To install this package directly from GitHub, start R and enter: @@ -34,7 +37,7 @@ if (!require("devtools", quietly = TRUE)) { install.packages("devtools") } -devtools::install_github("PNNL-CompBio/panSEA") +devtools::install_github("BelindaBGarana/panSEA") ``` If you are using Windows OS, you may need to change the code above to: @@ -43,7 +46,7 @@ if (!require("devtools", quietly = TRUE)) { install.packages("devtools") } -devtools::install_github("PNNL-CompBio/panSEA", build = FALSE) +devtools::install_github("BelindaBGarana/panSEA", build = FALSE) ``` # Case 1: 2 Groups (e.g., Diseased vs. Healthy) @@ -160,10 +163,7 @@ If you were using real transcriptomic data, you could use the default gmt.genes or adjust it to query the MSigDB; you could also use the default gmt.drugs, drug.sensitivity, and expression to query adherent CCLE RNA-seq data (version 19Q4) and the PRISM drug screen - -__THIS DOESNT WORK__ - -```{r, eval=FALSE} +```{r} panSEA.2groups <- panSEA::panSEA(data.list, types, gmt.features = gmt.features, gmt.drugs = gmt.drugs, drug.sensitivity = drug.sensitivity, @@ -197,8 +197,7 @@ paste0("https://raw.githubusercontent.com/BelindaBGarana/", ``` 2. Run panSEA and examine enrichment results visually -__Also doesn't work.__ -```{r, eval=FALSE} +```{r} panSEA.1group <- panSEA::panSEA(data.list, types, group.names = "Sensitive_vs_resistant_to_EGFRi", group.samples = list(2))