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Description
Protein modification and activity types are now namespace values. The specification mentions a default namespace and implies that it should have both sets of protein modification and activity types.
Set of values:
# Protein Modification types
Ac
acetylation
ADPRib
ADP-ribosylation
ADP-rybosylation
adenosine diphosphoribosyl
Farn
farnesylation
Gerger
geranylgeranylation
Glyco
glycosylation
Hy
hydroxylation
ISG
ISGylation
ISG15-protein conjugation
Me
methylation
Me1
monomethylation
mono-methylation
Me2
dimethylation
di-methylation
Me3
trimethylation
tri-methylation
Myr
myristoylation
Nedd
neddylation
NGlyco
N-linked glycosylation
NO
Nitrosylation
OGlyco
O-linked glycosylation
Palm
palmitoylation
Ph
phosphorylation
Sulf
sulfation
sulphation
sulfur addition
sulphur addition
sulfonation
sulphonation
Sumo
SUMOylation
Ub
ubiquitination
ubiquitinylation
ubiquitylation
UbK48
Lysine 48-linked polyubiquitination
UbK63
Lysine 63-linked polyubiquitination
UbMono
monoubiquitination
UbPoly
polyubiquitination
# Activity types (BEL 1.0 functions)
act
molecularActivity
cat
catalyticActivity
chap
chaperoneActivity
gtp
gtpBoundActivity
kin
kinaseActivity
pep
peptidaseActivity
phos
phosphataseActivity
ribo
ribosylationActivity
tscript
transcriptionalActivity
tport
transportActivity
Is this set accurate with respect to the BEL 2.0 specification? This default namespace is not defined as part of the specification so I'm unsure.
Also it seems reasonable to implement this as a namespace supported by OpenBEL. Users could then use this namespace as the DEFAULT in BEL Script using:
DEFINE DEFAULT NAMESPACE AS URI "http://www.openbel.org/bel/namespace/default"
act(p(HGNC:AKT1), ma(kin))
p(HGNC:AKT1, pmod(phosphorylation, Ser, 473))
What about the amino acid? Should the usual suspects be included in the default namespace?