From b349605d5791b05a27eb3e975a3bd85149fdc791 Mon Sep 17 00:00:00 2001 From: EnfxcFCb6 Date: Mon, 2 Jun 2025 17:47:16 -0400 Subject: [PATCH 1/2] Standardized README to Markdown format --- readme.html => README.md | 51 +++++++++++++++++++--------------------- 1 file changed, 24 insertions(+), 27 deletions(-) rename readme.html => README.md (57%) diff --git a/readme.html b/README.md similarity index 57% rename from readme.html rename to README.md index fb03be4..b128822 100644 --- a/readme.html +++ b/README.md @@ -1,44 +1,41 @@ -
+This model of cardiac sarcomere dynamics linked to calcium kinetics is implemented and  
+modified for Neuron by Francois E. Gannier and Claire O. Malecot  
+from University of Tours - FRANCE  
+Physiologie des Cellules Cardiaques et Vasculaires  
+email address: francois.gannier@univ-tours.fr  
 
-This model of cardiac sarcomere dynamics linked to calcium kinetics is implemented and
-modified for Neuron by Francois E. Gannier and Claire O. Malecot 
-	from University of Tours - FRANCE
-	Physiologie des Cellules Cardiaques et Vasculaires
-	email address: francois.gannier@univ-tours.fr
+It is based on the paper by :  
+Negroni JA & Lascano EC (1996) A cardiac muscle model relating sarcomere  
+dynamics to calcium kinetics. *J Mol Cell Cardio* 28:915-929 [ [PubMed](http://www.ncbi.nlm.nih.gov/pubmed/8762031) ]
 
-It is based on the paper by :
-Negroni JA & Lascano EC (1996) A cardiac muscle model relating sarcomere 
-dynamics to calcium kinetics. J Mol Cell Cardio 28:915-929 [PubMed]
-
-this is a now classic model of contraction which has been added in some recent models 
+this is a now classic model of contraction which has been added in some recent models  
 (eg : kyoto model (2003), Okada model (2005))
 
-it uses a four-state combination to show the relation between C-Troponin, calcium,
+it uses a four-state combination to show the relation between C-Troponin, calcium,  
 cross-bridges and Force.
 
-The orginal model was modified to allow several stimuli with self-chosen frequency.
+The orginal model was modified to allow several stimuli with self-chosen frequency.  
 (This allows to reproduce a staircase phenomenom)
  
-To run the simulation auto-launch the model from modeldb or download
+To run the simulation auto-launch the model from modeldb or download  
 and extract the archive and then compile the mod files under:
 
-unix/linux:
------------
-type nrnivmodl in the NegroniLascano folder and then
+## unix/linux:
+type nrnivmodl in the NegroniLascano folder and then  
 nrngui mosinit.hoc
 
-mswin:
-------
+## mswin:
 run mknrndll and then double click on mosinit.hoc
 
-MAC OS X:
---------
-
-Drag and drop the NegroniLascano folder onto the mknrndll icon.  Drag
+## MAC OS X:
+Drag and drop the NegroniLascano folder onto the mknrndll icon.  Drag  
 and drop the mosinit.hoc file onto the nrngui icon.
 
-Once the simulation starts it recreates a figure similar to Fig. 2 (shown as three 
-panels for clarity)& 3 of the original paper.
+Once the simulation starts it recreates a figure similar to Fig. 2 (shown as three  
+panels for clarity) & 3 of the original paper.
+
+![Figure 2 & 3](./fig2-3.jpg)
+
+---
 
-Figure 2 & 3
-
\ No newline at end of file +2025-06-02: Converted README to Markdown. \ No newline at end of file From e43d1b7cae7a823d30284f248c2e5d71e543894a Mon Sep 17 00:00:00 2001 From: rsakai Date: Wed, 4 Jun 2025 17:39:14 -0400 Subject: [PATCH 2/2] Update README.md --- README.md | 28 ++++++++++++++-------------- 1 file changed, 14 insertions(+), 14 deletions(-) diff --git a/README.md b/README.md index b128822..a9cd694 100644 --- a/README.md +++ b/README.md @@ -1,41 +1,41 @@ -This model of cardiac sarcomere dynamics linked to calcium kinetics is implemented and -modified for Neuron by Francois E. Gannier and Claire O. Malecot -from University of Tours - FRANCE +This model of cardiac sarcomere dynamics linked to calcium kinetics is implemented and +modified for Neuron by Francois E. Gannier and Claire O. Malecot +from University of Tours - FRANCE Physiologie des Cellules Cardiaques et Vasculaires email address: francois.gannier@univ-tours.fr It is based on the paper by : -Negroni JA & Lascano EC (1996) A cardiac muscle model relating sarcomere +Negroni JA & Lascano EC (1996) A cardiac muscle model relating sarcomere dynamics to calcium kinetics. *J Mol Cell Cardio* 28:915-929 [ [PubMed](http://www.ncbi.nlm.nih.gov/pubmed/8762031) ] -this is a now classic model of contraction which has been added in some recent models +this is a now classic model of contraction which has been added in some recent models (eg : kyoto model (2003), Okada model (2005)) -it uses a four-state combination to show the relation between C-Troponin, calcium, +it uses a four-state combination to show the relation between C-Troponin, calcium, cross-bridges and Force. -The orginal model was modified to allow several stimuli with self-chosen frequency. +The orginal model was modified to allow several stimuli with self-chosen frequency. (This allows to reproduce a staircase phenomenom) -To run the simulation auto-launch the model from modeldb or download +To run the simulation auto-launch the model from modeldb or download and extract the archive and then compile the mod files under: ## unix/linux: -type nrnivmodl in the NegroniLascano folder and then -nrngui mosinit.hoc +type `nrnivmodl` in the NegroniLascano folder and then +`nrngui mosinit.hoc` ## mswin: -run mknrndll and then double click on mosinit.hoc +run `mknrndll` and then double click on `mosinit.hoc` ## MAC OS X: -Drag and drop the NegroniLascano folder onto the mknrndll icon. Drag +Drag and drop the NegroniLascano folder onto the mknrndll icon. Drag and drop the mosinit.hoc file onto the nrngui icon. -Once the simulation starts it recreates a figure similar to Fig. 2 (shown as three +Once the simulation starts it recreates a figure similar to Fig. 2 (shown as three panels for clarity) & 3 of the original paper. ![Figure 2 & 3](./fig2-3.jpg) --- -2025-06-02: Converted README to Markdown. \ No newline at end of file +2025-06-02: Converted README to Markdown.