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-
-
-This model of cardiac sarcomere dynamics linked to calcium kinetics is implemented and
+This model of cardiac sarcomere dynamics linked to calcium kinetics is implemented and
modified for Neuron by Francois E. Gannier and Claire O. Malecot
- from University of Tours - FRANCE
- Physiologie des Cellules Cardiaques et Vasculaires
- email address: francois.gannier@univ-tours.fr
+from University of Tours - FRANCE
+Physiologie des Cellules Cardiaques et Vasculaires
+email address: francois.gannier@univ-tours.fr
-It is based on the paper by :
+It is based on the paper by :
Negroni JA & Lascano EC (1996) A cardiac muscle model relating sarcomere
-dynamics to calcium kinetics. J Mol Cell Cardio 28:915-929 [PubMed]
+dynamics to calcium kinetics. *J Mol Cell Cardio* 28:915-929 [ [PubMed](http://www.ncbi.nlm.nih.gov/pubmed/8762031) ]
this is a now classic model of contraction which has been added in some recent models
(eg : kyoto model (2003), Okada model (2005))
-it uses a four-state combination to show the relation between C-Troponin, calcium,
+it uses a four-state combination to show the relation between C-Troponin, calcium,
cross-bridges and Force.
-The orginal model was modified to allow several stimuli with self-chosen frequency.
+The orginal model was modified to allow several stimuli with self-chosen frequency.
(This allows to reproduce a staircase phenomenom)
-To run the simulation auto-launch the model from modeldb or download
+To run the simulation auto-launch the model from modeldb or download
and extract the archive and then compile the mod files under:
-unix/linux:
------------
-type nrnivmodl in the NegroniLascano folder and then
-nrngui mosinit.hoc
-
-mswin:
-------
-run mknrndll and then double click on mosinit.hoc
+## unix/linux:
+type `nrnivmodl` in the NegroniLascano folder and then
+`nrngui mosinit.hoc`
-MAC OS X:
---------
+## mswin:
+run `mknrndll` and then double click on `mosinit.hoc`
-Drag and drop the NegroniLascano folder onto the mknrndll icon. Drag
+## MAC OS X:
+Drag and drop the NegroniLascano folder onto the mknrndll icon. Drag
and drop the mosinit.hoc file onto the nrngui icon.
Once the simulation starts it recreates a figure similar to Fig. 2 (shown as three
-panels for clarity)& 3 of the original paper.
+panels for clarity) & 3 of the original paper.
+
+
+
+---
-
-
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+2025-06-02: Converted README to Markdown.