Somehow, Lifeguard causes SpringBoard to crash to Safe Mode, randomly once again, when using a Bluetooth Keyboard. This appears to occur quite frequently when trying to input the passcode required to unlock the device.
I have confirmed (at least I think I did) that Lifeguard is in fact the culprit as I isolated the tweak along with Cr4shed using iCleaner and the device still crashed to Safe Mode.
If it amounts to anything, I am using an iPad Air 2 that is running iPadOS 13.5.1.