loopless sampling

[hariszaf]

Thermodynamics constraints are rather important in metabolic modeling.
If not considered, they would lead to thermodynamically infeasible/implausible flux loops within flux sample.

Loopless space though is a non-convex one.
Approaches such as the LooplessFluxSampler could be used for more valid sampling from the biological point of view.

Further literature:

• Elimination of Thermodynamically Infeasible Loops in Steady-State Metabolic Models
• Extreme Pathways and Kirchhoff's Second Law

[vikasgrewal16]

I want to contribute to this issue but i am having a difficulty to understand this. Can you please tell me how can I do this @hariszaf