diff --git a/projects/packages/jetpack-mu-wpcom/changelog/add-agents-manager-block-editor-filter b/projects/packages/jetpack-mu-wpcom/changelog/add-agents-manager-block-editor-filter
new file mode 100644
index 00000000000..be1be6069f7
--- /dev/null
+++ b/projects/packages/jetpack-mu-wpcom/changelog/add-agents-manager-block-editor-filter
@@ -0,0 +1,4 @@
+Significance: patch
+Type: added
+
+Agents Manager: Add `agents_manager_enqueue_in_block_editor` filter to allow preventing enqueue in block editor contexts.
diff --git a/projects/packages/jetpack-mu-wpcom/src/features/agents-manager/class-agents-manager.php b/projects/packages/jetpack-mu-wpcom/src/features/agents-manager/class-agents-manager.php
index da079b10a22..891a2bb977f 100644
--- a/projects/packages/jetpack-mu-wpcom/src/features/agents-manager/class-agents-manager.php
+++ b/projects/packages/jetpack-mu-wpcom/src/features/agents-manager/class-agents-manager.php
@@ -311,6 +311,23 @@ private function get_variant() {
 	 * @return bool
 	 */
 	private function is_enabled() {
+		// Allow environments (e.g. CIAB) to prevent loading in block editor contexts
+		// where agents-manager is already running from the parent page.
+		/**
+		 * Filter whether to enqueue Agents Manager assets inside the block editor iframe.
+		 *
+		 * This allows environments that already run Agents Manager from the parent page
+		 * to disable enqueueing a second instance within the block editor context.
+		 *
+		 * @param bool $enqueue_in_block_editor Whether to enqueue Agents Manager assets
+		 *                                      in the block editor iframe. Default true.
+		 *
+		 * @return bool Whether to enqueue Agents Manager assets in the block editor iframe.
+		 */
+		if ( $this->is_block_editor() && ! apply_filters( 'agents_manager_enqueue_in_block_editor', true ) ) {
+			return false;
+		}
+
 		// Full unified experience: Agents Manager with support guides, Help Center takeover, etc.
 		if ( apply_filters( 'agents_manager_use_unified_experience', false ) ) {
 			return true;
diff --git a/projects/packages/jetpack-mu-wpcom/tests/php/features/agents-manager/Agents_Manager_Test.php b/projects/packages/jetpack-mu-wpcom/tests/php/features/agents-manager/Agents_Manager_Test.php
index b7920ed435f..bf9e545f715 100644
--- a/projects/packages/jetpack-mu-wpcom/tests/php/features/agents-manager/Agents_Manager_Test.php
+++ b/projects/packages/jetpack-mu-wpcom/tests/php/features/agents-manager/Agents_Manager_Test.php
@@ -1356,6 +1356,44 @@ public function test_should_enqueue_script_preview_check_takes_precedence_over_u
 		$this->assertFalse( $result );
 	}
 
+	/**
+	 * Tests that should_enqueue_script returns false in block editor when
+	 * agents_manager_enqueue_in_block_editor filter returns false.
+	 *
+	 * This allows environments like CIAB to prevent duplicate loading when
+	 * agents-manager is already running from the parent page.
+	 */
+	public function test_should_enqueue_script_returns_false_in_block_editor_when_filter_disables_it() {
+		require_once ABSPATH . 'wp-admin/includes/screen.php';
+
+		// Set up block editor context.
+		set_current_screen( 'post' );
+		$screen = get_current_screen();
+
+		// Use reflection to set the is_block_editor property.
+		$reflection = new \ReflectionClass( $screen );
+		$property   = $reflection->getProperty( 'is_block_editor' );
+		if ( PHP_VERSION_ID < 80100 ) {
+			$property->setAccessible( true );
+		}
+		$property->setValue( $screen, true );
+
+		$_SERVER['REQUEST_URI'] = '/wp-admin/post.php';
+
+		// Enable unified experience so should_enqueue_script() would otherwise return true,
+		// ensuring this test actually exercises the agents_manager_enqueue_in_block_editor filter.
+		add_filter( 'agents_manager_use_unified_experience', '__return_true', 20 );
+		// Disable enqueue in block editor via the new filter.
+		add_filter( 'agents_manager_enqueue_in_block_editor', '__return_false' );
+
+		$result = $this->call_should_enqueue_script();
+
+		remove_filter( 'agents_manager_use_unified_experience', '__return_true', 20 );
+		remove_filter( 'agents_manager_enqueue_in_block_editor', '__return_false' );
+
+		$this->assertFalse( $result );
+	}
+
 	/**
 	 * Helper to call the private get_current_user_data method via reflection.
 	 *